Immunomodulatory effects of Abnormal Savda Munsiq, a traditional Uighur medicine, on the combined stress mice.
OBJECTIVE
To investigate the immunomodulatory effects of ASMq, a herbal preparation used in Traditional Uighur Medicine, on the combined stress mice.


METHODS
The combined stress was induced on mice by application of the electric-foot shock in a cold-dry environment and three different doses of ASMq were orally administered to the animals for 14 days. The effect of ASMq on the immune apparatus weight index, lymphocytes proliferation, serum levels of the cytokines, immunoglobulins, hemolysin and NK cells as well as the phagocytic activity of the macrophages were evaluated.


RESULTS
Oral administration of ASMq was found to increase the thymus and spleen indices, lymphocytes proliferation induced by Con A and LPS, the percentage of CD4(+) in thymus, spleen and peripheral blood and restore the CD4(+)/CD8(+) ratio. The serum concentrations of INF-beta, IL-2, IL-6, IgG, NK cells and hemolysin were also increased. The macrophage phagocytic activity was also enhanced.
Amat
Nurmuhammat
N
Traditional Uighur Medicine Department, Xinjiang Medical University, 8 Medical University Road, Urumqi 830054, Xinjiang, China.
Upur
Halmurat
H
Ablimit
Adiljan
A
Matsidik
Aynur
A
Yusup
Abdirhim
A
Kijjoa
Anake
A
D000818:Animals; D016516:CD4-CD8 Ratio; D004597:Electroshock; D006460:Hemolysin Proteins / Q000378:metabolism; D007107:Immune System / Q000187:drug effects*; D007136:Immunoglobulins / Q000378:metabolism; D007155:Immunologic Factors / Q000494:pharmacology*; D016899:Interferon-beta / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000502:physiology; D019684:Magnoliopsida; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects; D013312:Stress, Physiological / Q000276:immunology*; D013950:Thymus Gland / Q000187:drug effects
D006460:Hemolysin Proteins; D007136:Immunoglobulins; D007155:Immunologic Factors; D007376:Interleukin-2; D015850:Interleukin-6; D010936:Plant Extracts; D016899:Interferon-beta