title: Coffee, decaffeinated coffee, tea intake, and risk of renal cell cancer.
abstract: The relation between coffee, decaffeinated coffee, and tea intake and renal cell carcinoma (RCC) risk was analyzed in a case-control study conducted in Italy between 1992 and 2004. Cases were 767 subjects with incident histologically confirmed RCC and controls were 1,534 patients in hospital for acute non neoplastic conditions. Odds ratios (OR) and 95% confidence intervals (CI) for RCC were computed by multiple logistic regression models, conditioned on study center, sex, and age. Coffee intake (mostly espresso and mocha) was not associated with RCC risk, with an OR of 1.02 (95% CI 0.73-1.43) in drinkers of > or = 4 cups/day compared with drinkers of < 1 cup/day. The corresponding ORs were 1.34 (95% CI 0.87-2.07) in men and 0.67 (95% CI 0.38-1.18) in women, 1.91 (95% CI 0.85-4.31) in current smokers and 0.74 (95% CI 0.41-1.31) in never smokers, with no trend in risk with dose. No relation was observed with decaffeinated coffee (OR = 1.38, 95% CI 0.94-2.03 for drinkers compared with nondrinkers) and tea intake (OR = 0.78, 95% CI 0.59-1.05 for drinkers of > or = 1 cup/day compared with nondrinkers). No significant heterogeneity was found for coffee intake across strata of age, education, body mass index, and consumption of sugar. This study, based on a large dataset, provides further evidence that coffee, decaffeinated coffee, and tea consumption are not related to RCC risk.
authors.affiliation: Servizio di Epidemiologia, Istituto Tumori Fondazione Pascale, Naples, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.forename: Irene
authors.initials: I
authors.lastname: Tramacere
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tavani
authors.forename: Silvano
authors.initials: S
authors.lastname: Gallus
authors.forename: Anna
authors.initials: A
authors.lastname: Crispo
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Luigino
authors.initials: L
authors.lastname: Dal Maso
authors.forename: Valerio
authors.initials: V
authors.lastname: Ramazzotti
authors.forename: Carlotta
authors.initials: C
authors.lastname: Galeone
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000328:Adult; D000368:Aged; D001628:Beverages; D002110:Caffeine / Q000009:adverse effects / Q000494:pharmacology*; D002292:Carcinoma, Renal Cell / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology; D016022:Case-Control Studies; D003069:Coffee; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000453:epidemiology* / Q000209:etiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking; D013662:Tea; D055815:Young Adult
chemical_list: D003069:Coffee; D013662:Tea; D002110:Caffeine