title: Visualization of neuromelanin in the Substantia nigra and locus ceruleus at 1.5T using a 3D-gradient echo sequence with magnetization transfer contrast.
abstract: Recent technical advances have enabled the visualization of neuromelanin in the substantia nigra pars compacta (SNc) and locus ceruleus (LC) by 3-tesla (T) magnetic resonance imaging in vivo. In the present study, we successfully detected neuromelanin in the SNc and LC of 6 healthy volunteers at 1.5T using a 3D gradient echo sequence with off-resonance magnetization transfer contrast.
authors.affiliation: Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. raizo@med.nagoya-u.ac.jp
authors.forename: Toshiki
authors.initials: T
authors.lastname: Nakane
authors.forename: Takashi
authors.initials: T
authors.lastname: Nihashi
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawai
authors.forename: Shinji
authors.initials: S
authors.lastname: Naganawa
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008125:Locus Coeruleus / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008543:Melanins / Q000032:analysis*; D008875:Middle Aged; D013378:Substantia Nigra / Q000737:chemistry*; D055815:Young Adult
chemical_list: D008543:Melanins; C014121:neuromelanin