title: Generalized eruptive keratoacanthomas of Grzybowski treated with isotretinoin.
abstract: Generalized eruptive keratoacanthomas of Grzybowski is a rare condition of unknown etiology. The disease is characterized by the abrupt onset of many small crateriform papules on the skin and mucous membranes. The authors report of a man with multiple eruptive keratoacanthomas of Grzybowski who responded favorably to oral isotretinoin therapy. After 2 years of follow-up, a complete regression of all lesions was observed, and this rapid clearance under isotretinoin therapy is intriguing with regard to the possible etiology of the condition.
authors.affiliation: Presbyterian- St. Luke's Hospital, Denver, CO, USA.
authors.forename: Travis
authors.initials: T
authors.lastname: Vandergriff
authors.forename: Krystal
authors.initials: K
authors.lastname: Nakamura
authors.forename: Whitney A
authors.initials: WA
authors.lastname: High
mesh_terms: D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D015603:Keratinocytes / Q000187:drug effects / Q000473:pathology; D007636:Keratoacanthoma / Q000188:drug therapy* / Q000473:pathology*; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin