[Proliferative activity of rat skin fibroblasts under the action of glucocorticoids and gestagens].
Temporal and concentration dependences of the effect of the new synthetic gestagen 17alpha-acetoxy-3beta-butanoyloxy-6-methyl-pregna-4,6-dien-20-one (ABMP) and reference glucocorticoids (dexamethasone and hydrocortisone) and progesterone on the proliferative activity of rat skin fibroblasts were examined using the MTT assay. The results demonstrated that ABMP along with glucocorticoids produced an antiproliferative action against fibroblasts, with the maximum (38%) suppression of the metabolic activity of cells observed after 5-day incubation at a drug concentration of 10(-5) M.
Liga
A B
AB
Ukhina
T V
TV
Rzheznikov
V M
VM
Shimanovskiĭ
N L
NL
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology*; D011372:Progestins / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000166:cytology / Q000378:metabolism*
D005938:Glucocorticoids; D011372:Progestins