Genetic correlates of protection against HIV infection: the ally within.
Repeated exposure to HIV does not necessarily result in infection and HIV infection does not inevitably lead to the development of the AIDS. Multiple immunological and genetic features can confer resistance to HIV acquisition and progression at different steps in viral infection; a full understanding of these mechanisms could result in the development of novel therapeutic and vaccine approaches for HIV infection. In this review, we focus on the genetic mechanisms associated with resistance to HIV infection and to the progression to AIDS.
Piacentini
L
L
Department of Preclinical Sciences, University of Milan, Segrate, Milan, Italy.
Biasin
M
M
Fenizia
C
C
Clerici
M
M
D000483:Alleles; D016207:Cytokines / Q000235:genetics; D018450:Disease Progression; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000276:immunology*; D020276:HIV Long-Term Survivors; D018023:HIV Seronegativity / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D011401:Promoter Regions, Genetic; D019713:Receptors, CCR5 / Q000235:genetics
D016207:Cytokines; D006680:HLA Antigens; D019713:Receptors, CCR5