Molecular mechanisms of TRP regulation in tumor growth and metastasis.
Transient Receptor Potential (TRP) channels modulate intracellular Ca2+ concentrations, consequently affecting both cell death and proliferation. It is not, therefore, surprising that the membrane expression of some TRP channels is altered during tumor growth and metastasis. These variations in channel abundance are due to TRP regulation on the transcriptional, translational, and targeting levels. This article mainly reviews the transcriptional mechanisms modulating TRP expression during tumorigenesis, involving hormones, growth factors, and alternative splicing.
Gkika
Dimitra
D
Inserm U800, Equipe labellisée par la Ligue Nationale Contre le Cancer, F59656 Villeneuve d'Ascq, France.
Prevarskaya
Natalia
N
D015972:Gene Expression Regulation, Neoplastic; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000235:genetics / Q000378:metabolism*
D012739:Gonadal Steroid Hormones; D036341:Intercellular Signaling Peptides and Proteins; D020033:Protein Isoforms; D050051:Transient Receptor Potential Channels