title: In vitro and in vivo degradation of poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) elastomers.
abstract: Biomaterials with a wide range of tunable properties are desirable for application-specific purposes. We have previously developed a class of elastomeric poly(ester amides) based on the amine alcohol 1,3-diamino-2-hydroxypropane termed poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate) or APS. In this work, we have synthesized and characterized formulations of APS polymers and studied the degradation of these polymers in vitro and in vivo. It was found that the chemical, physical, and mechanical properties of APS polymers could be tuned by adjusting monomer feed ratios and polymerization conditions. The degradation kinetics could also be greatly influenced by altering the formulation of APS polymers. In vivo degradation half-lives ranged from 6 to approximately 100 weeks. Furthermore, the dominant degradation mechanism (i.e. hydrolytic or enzymatic) could be controlled by adjusting the specific formulation of the APS polymer. On the basis of the observed in vitro and in vivo biodegradation phenomena, we also propose that the primary modes of degradation are composition dependent.
authors.affiliation: Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E25-342, Cambridge, Massachusetts 02139, USA.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Bettinger
authors.forename: Joost P
authors.initials: JP
authors.lastname: Bruggeman
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Borenstein
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D003652:Decanoic Acids / Q000737:chemistry / Q000378:metabolism*; D003998:Dicarboxylic Acids / Q000737:chemistry / Q000378:metabolism*; D020724:Elastomers / Q000737:chemistry / Q000378:metabolism*; D004602:Elements; D020007:Implants, Experimental; D007700:Kinetics; D055595:Mechanical Phenomena; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D009757:Nylons / Q000737:chemistry / Q000378:metabolism*; D011091:Polyesters / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D044366:Transition Temperature
chemical_list: D001672:Biocompatible Materials; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D020724:Elastomers; D004602:Elements; D009757:Nylons; D011091:Polyesters; C546960:poly(1,3-diamino-2-hydroxypropane-co-polyol sebacate); C011107:sebacic acid