Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters.
OBJECTIVE
To evaluate the plasma asymmetric dimethyl arginine (ADMA) levels and carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS).


METHODS
Prospective study.


METHODS
University medical center.


METHODS
Thirty-five patients with PCOS and 31 healthy controls.


METHODS
Peripheral venous puncture, ultrasonography, oral glucose tolerance test (OGTT).


METHODS
Plasma ADMA, serum FSH, LH, dehydroepiandrosterone sulfate (DHEAS), free T and total T, insulin, fasting plasma glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, homocysteine, fibrinogen, C-reactive protein, and carotid IMT.


RESULTS
The PCOS group had higher levels of androgens, triglycerides, homocysteine, insulin, and homeostasis model assessment of insulin resistance when compared with controls. There were no significant differences in ADMA levels and IMT between the two groups. The fasting plasma glucose, total cholesterol, HDL cholesterol, LDL cholesterol, fibrinogen, and C-reactive protein levels were not different among the groups. Intima-media thickness was significantly correlated with DHEAS, but there was no association between IMT and ADMA.


CONCLUSIONS
Results of our study revealed that ADMA levels and carotid IMT in patients with PCOS are not different from healthy controls.
Pamuk
Baris Onder
BO
Department of Internal Medicine, Division of Endocrinology and Metabolism, Baskent University, School of Medicine, 5th street, 48, Bahcelievler, 06490 Ankara, Turkey. bopamuk@gmail.com
Torun
Ayse Nur
AN
Kulaksizoglu
Mustafa
M
Ertugrul
Derun
D
Ciftci
Ozgur
O
Kulaksizoglu
Sevsen
S
Yildirim
Erkan
E
Demirag
Nilgun Guvener
NG
D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism; D011446:Prospective Studies; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D017540:Tunica Media / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult
C018524:N,N-dimethylarginine; D001120:Arginine