Experimental infection of rodent mammals for fungal virulence testing.
Invasive fungal infections comprise a group of serious and life-threatening diseases affecting immunocompromised patients. Molecular analysis of fungal virulence involves the deletion of genes that are suspected for contributing to fungal pathogenesis. Phenotypic analysis of the generated mutants includes in vivo infection experiments in order to assign a function during fungal disease to a gene of interest.
Schweizer
Anja
A
Comparative Genomics Centre, Cellular Immunology Group, James Cook University, Townsville, Australia.
Schröppel
Klaus
K
D000818:Animals; D002176:Candida albicans / Q000235:genetics / Q000472:pathogenicity*; D002177:Candidiasis / Q000209:etiology; D005260:Female; D016469:Fungemia / Q000209:etiology; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D009172:Mycology / Q000379:methods*; D014774:Virulence / Q000235:genetics