title: Distribution and genesis of the RFRP-producing neurons in the rat brain: comparison with melanin-concentrating hormone- and hypocretin-containing neurons.
abstract: Prepro-RFRP-containing neurons have recently been described in the mammalian brain. These neurons are only found in the tuberal hypothalamus. In this work, we have provided a detailed analysis of the distribution of cells expressing the RFRP mRNA, and found them in seven anatomical structures of the tuberal hypothalamus. No co-expression with melanin-concentrating hormone (MCH) or hypocretin (Hcrt), that are also described in neurons of the tuberal hypothalamus, was observed. Using the BrdU method, we found that all RFRP cell bodies are generated between E13 and E14. Thus, RFRP neurons form a specific cell population with a complex distribution pattern in the tuberal hypothalamus. However, they are generated in one peak. These observations are discussed with data concerning the distribution and genesis of the MCH and Hcrt cell populations that are also distributed in the tuberal hypothalamus.
authors.affiliation: EA3922, Université de Franche-Comté, Faculté de Médecine et de Pharmacie, 19 rue Ambroise Paré, 25000 Besançon, France.
authors.forename: K
authors.initials: K
authors.lastname: Legagneux
authors.forename: G
authors.initials: G
authors.lastname: Bernard-Franchi
authors.forename: F
authors.initials: F
authors.lastname: Poncet
authors.forename: A
authors.initials: A
authors.lastname: La Roche
authors.forename: C
authors.initials: C
authors.lastname: Colard
authors.forename: D
authors.initials: D
authors.lastname: Fellmann
authors.forename: F
authors.initials: F
authors.lastname: Pralong
authors.forename: P Y
authors.initials: PY
authors.lastname: Risold
mesh_terms: D000818:Animals; D005260:Female; D006801:Humans; D007028:Hypothalamic Hormones / Q000235:genetics / Q000378:metabolism*; D007031:Hypothalamus / Q000166:cytology* / Q000196:embryology; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008543:Melanins / Q000235:genetics / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism*; D000068797:Orexins; D010907:Pituitary Hormones / Q000235:genetics / Q000378:metabolism*; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D007028:Hypothalamic Hormones; D047908:Intracellular Signaling Peptides and Proteins; D008543:Melanins; D009479:Neuropeptides; D000068797:Orexins; D010907:Pituitary Hormones; D011498:Protein Precursors; C416987:RFamide peptide; C019463:melanin-concentrating hormone