title: [Changes in the respiratory tract epithelium of the rats infected after the exposure to a prolonged emotional-painful stress: effect of oxytocin].
abstract: Effect of oxytocin on the respiratory tract epithelium of rats infected with Escherichia coli following the prolonged emotional-painful stress, was studied using the methods of histochemistry, immunocytochemistry, light and electron microscopy. It was found, that prolonged stress caused the exertion of protective-adaptive capacities of the epithelium, while the administration of an antigen resulted in the failure of adaptational mechanisms. Oxytocin was found to participate in the formation of the response of the epithelial secretory cells to stressful influences by activating their protective functions. It stimulated and supported the protein-synthetic (CC16 protein production by Clara cells) and mucin-producing (goblet cells) functions of secretory cells, thus stabilizing the protective epithelial mechanisms under the conditions of intense functioning.
authors.forename: A N
authors.initials: AN
authors.lastname: Kozlova
mesh_terms: D000818:Animals; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009077:Mucins / Q000378:metabolism; D010121:Oxytocin / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy / Q000473:pathology*; D051381:Rats; D020545:Respiratory Mucosa / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D013315:Stress, Psychological / Q000188:drug therapy / Q000473:pathology*; D014598:Uteroglobin / Q000378:metabolism
chemical_list: D009077:Mucins; D010121:Oxytocin; D014598:Uteroglobin