Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.
A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (P(UNC) = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.
Rakovic
Aleksandar
A
Department of Neurology, University of Lübeck, Lübeck, Germany.
Stiller
Barbara
B
Djarmati
Ana
A
Flaquer
Antonia
A
Freudenberg
Jan
J
Toliat
Mohammad-Reza
MR
Linnebank
Michael
M
Kostic
Vladimir
V
Lohmann
Katja
K
Paus
Sebastian
S
Nürnberg
Peter
P
Kubisch
Christian
C
Klein
Christine
C
Wüllner
Ullrich
U
Ramirez
Alfredo
A
D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D006180:Proton-Translocating ATPases / Q000235:genetics*
C514983:ATP13A2 protein, human; D006180:Proton-Translocating ATPases