[Arrhythmia and vegetative imbalance in hypothyrosis patients].
OBJECTIVE
To examine disturbances of cardiac rhythm and effects of autonomic nervous system on cardiovascular system in hypothyrosis patients as shown by circadian ECG monitoring.


METHODS
A total of 171 patients with primary hypothyrosis (11 males, 160 females, mean age 56.2 +/- 4.8 years) were examined with circadian ECG monitoring. The patients were divided into two groups by the degree of hypothyrosis compensation. Group 1 (n = 87) had primary hypothyrosis in decompensation (TTH 14.78 +/- 1.3 mIU/l), group 2 (n = 84) had compensated hypothyrosis treated with sodium levothyroxin as replacement therapy (TTH 1.32 +/- 0.3 mIU/l).


RESULTS
It was found that group 1 patients have bradycardia, subnormal circadian index, prolonged corrected interval Q-T, inhibition of atrioventricular conduction, increased number of supra- and ventricular extrasystoles, predominance of the parasympathetic autonomic nervous system in regulation of heart rhythm.


CONCLUSIONS
Decompensated hypothyrosis is accompanied with significant disorders of cardiac activity and imbalance of autonomic nervous system which are corrected in hypothyrosis compensation.
Makusheva
M V
MV
Kileĭnikov
D V
DV
D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000453:epidemiology*; D001342:Autonomic Nervous System Diseases / Q000188:drug therapy / Q000453:epidemiology*; D015897:Comorbidity; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D013974:Thyroxine / Q000627:therapeutic use
D013974:Thyroxine