Visualization of neuromelanin in the Substantia nigra and locus ceruleus at 1.5T using a 3D-gradient echo sequence with magnetization transfer contrast.
Recent technical advances have enabled the visualization of neuromelanin in the substantia nigra pars compacta (SNc) and locus ceruleus (LC) by 3-tesla (T) magnetic resonance imaging in vivo. In the present study, we successfully detected neuromelanin in the SNc and LC of 6 healthy volunteers at 1.5T using a 3D gradient echo sequence with off-resonance magnetization transfer contrast.
Nakane
Toshiki
T
Department of Radiology, Nagoya University Graduate School of Medicine, Nagoya, Japan. raizo@med.nagoya-u.ac.jp
Nihashi
Takashi
T
Kawai
Hisashi
H
Naganawa
Shinji
S
D000328:Adult; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008125:Locus Coeruleus / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008543:Melanins / Q000032:analysis*; D008875:Middle Aged; D013378:Substantia Nigra / Q000737:chemistry*; D055815:Young Adult
D008543:Melanins; C014121:neuromelanin