Antifungal triterpene glycosides from the sea cucumber Bohadschia marmorata.
Four new holostan-type triterpene glycosides, marmoratoside A ( 1), 17 alpha-hydroxy impatienside A ( 2), marmoratoside B ( 3), 25-acetoxy bivittoside D ( 4), together with two known triterpene glycosides, impatienside A ( 5) and bivittoside D ( 6), were isolated from the sea cucumber Bohadschia Marmorata Jaeger. On the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions, the structures of the new triterpene glycosides were elucidated. Compounds 1, 2, 5, and 6 exhibited significant antifungal activity against six strains (0.70 < or = MIC (80) < or = 2.81 microM).
Yuan
Wei-Hua
WH
Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
Yi
Yang-Hua
YH
Tang
Hai-Feng
HF
Liu
Bao-Shu
BS
Wang
Zeng-Lei
ZL
Sun
Guo-Quan
GQ
Zhang
Wen
W
Li
Ling
L
Sun
Peng
P
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D000935:Antifungal Agents; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes