title: Transposon tools hopping in vertebrates.
abstract: In the past decade, tools derived from DNA transposons have made major contributions to vertebrate genetic studies from gene delivery to gene discovery. Multiple, highly complementary systems have been developed, and many more are in the pipeline. Judging which DNA transposon element will work the best in diverse uses from zebrafish genetic manipulation to human gene therapy is currently a complex task. We have summarized the major transposon vector systems active in vertebrates, comparing and contrasting known critical biochemical and in vivo properties, for future tool design and new genetic applications.
authors.affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Ni
authors.forename: Karl J
authors.initials: KJ
authors.lastname: Clark
authors.forename: Scott C
authors.initials: SC
authors.lastname: Fahrenkrug
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Ekker
mesh_terms: D000818:Animals; D004247:DNA / Q000235:genetics; D004251:DNA Transposable Elements; D018014:Gene Transfer Techniques; D005822:Genetic Vectors; D008954:Models, Biological; D015027:Zebrafish / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D004247:DNA