title: Patients' attitudes to medicines and adherence to maintenance treatment in inflammatory bowel disease.
abstract: BACKGROUND
  Nonadherence has been reported in over 40% of patients taking maintenance therapies (MT) for inflammatory bowel disease (IBD). Studies in other illness groups have shown that nonadherence is related to negative attitudes to treatment. The aim of this study was to assess patients' attitudes to MT for IBD (beliefs about personal need for MT and potential adverse effects) and to identify whether such beliefs are associated with adherence to MT.
  
  
  METHODS
  A cross-sectional survey was conducted in which 1871 members of the National Association for Colitis and Crohn's Disease (NACC) completed validated questionnaires assessing beliefs about MT and adherence to MT.
  
  
  RESULTS
  Low adherence to MT was reported by 29% of participants and was associated with doubts about personal need for MT (odds ratio [OR] = 0.56; 95% confidence interval [CI]: 0.48-0.64; P < 0.001) and concerns about potential adverse effects (OR = 1.66; 95% CI: 1.42-1.94; P < 0.001). Attitudinal analysis showed that while almost half (48%) of the participants were "accepting" of MT (high necessity, low concerns), a large proportion of the sample (42%) were "ambivalent" about MT (high necessity, high concerns), 6% were "sceptical" (low necessity, high concerns) and 4% were "indifferent" (low necessity, low concerns). Compared to those who were "accepting" of MT, participants in all 3 other attitudinal groups were significantly more likely to be nonadherent.
  
  
  CONCLUSIONS
  The way in which patients judge their personal need for MT relative to their concerns about MT can be a significant barrier to adherence. Interventions to facilitate optimal adherence to MT for IBD should address such perceptual barriers.
authors.affiliation: Centre for Behavioural Medicine, Department of Practice & Policy, School of Pharmacy, University of London, London, UK. rob.horne@pharmacy.ac.uk
authors.forename: Rob
authors.initials: R
authors.lastname: Horne
authors.forename: Rhian
authors.initials: R
authors.lastname: Parham
authors.forename: Richard
authors.initials: R
authors.lastname: Driscoll
authors.forename: Andrew
authors.initials: A
authors.lastname: Robinson
mesh_terms: D000328:Adult; D000368:Aged; D001294:Attitude to Health; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000523:psychology*; D003424:Crohn Disease / Q000523:psychology* / Q000628:therapy*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016015:Logistic Models; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D011795:Surveys and Questionnaires
chemical_list: D007166:Immunosuppressive Agents