title: Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity.
abstract: Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 μg mL(-1)), triterpenoids as bassic acid (MIC = 2.5 μg mL(-1)), α-amyrin acetate (MIC = 62.5 μg mL(-1)), a mixture of lupeol, α- and β-amyrin (MIC = 31.5 μg mL(-1)) and a mixture of lupeol, and acetates of α- and β-amyrin (MIC = 31.5 μg mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).
authors.affiliation: Unesp, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú km 01, CEP 14801-902, Araraquara-SP, Brazil.
authors.forename: C T
authors.initials: CT
authors.lastname: Higuchi
authors.forename: M
authors.initials: M
authors.lastname: Sannomiya
authors.forename: F R
authors.initials: FR
authors.lastname: Pavan
authors.forename: S R A
authors.initials: SR
authors.lastname: Leite
authors.forename: D N
authors.initials: DN
authors.lastname: Sato
authors.forename: S G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: L V S
authors.initials: LV
authors.lastname: Sacramento
authors.forename: W
authors.initials: W
authors.lastname: Vilegas
authors.forename: C Q F
authors.initials: CQ
authors.lastname: Leite