Prevalence of human herpes virus-8 and hepatitis B virus among HIV seropositive pregnant women enrolled in the Mother-to-Child HIV Transmission Prevention Program at Saint Camille Medical Centre in Burkina Faso.
The aims of this research are: i) to evaluate the prevalence of HHV-8, HBV and HIV among pregnant women, ii) to determine the percentage of these co-infections and iii) to estimate the frequency of the mother-to-child transmission of HIV among HBV and HHV-8 positive mothers. Thus, 379 pregnant women attending ante-natal consultation in Saint Camille Medical Centre were subject to HIV, HHV-8 antibodies and the viral marker Hepatitis B Surface Antigen (HBsAg) detection. We observed 48/379 (12.66%) HIV seropositive subjects. Among them, HIV-1 type infection was predominant (95.83%), only 2/48 (4.17%) subjects had a dual HIV-1 type and HIV-2 type infection, no single HIV-2 type infection was detected. 38/379 (10.02%) subjects were infected by HHV-8 and 30/379 (7.91%) were HBsAg positive. HHV-8 and HIV Co-infections rates were high within HBV positive patients and we had respectively 20.00 and 16.67%. 10.42% HIV positive women were coinfected by HBV while 12.50% were infected by HHV-8. Then, 15.79% subjects HHV-8 positive were co-infected by HBV or HIV. In spite of the PMTCT protocol application, five (10.42%) HIV positive women transmitted the virus to their children. Two HIV positive mothers were co-infected by HHV-8 and one by HBV. Among the 5 HIV infected, one mother (20.0%) was HBV positive and two (40.0%) HHV-8 positive. Although we did not have a large sample which would show large prélalences of the infections, we could put forward that the Co-infection of the HIV with one of these viruses (HBV or HHV-8) could favorite the mother-to-child transmission.
Ilboudo
Denise
D
Laboratoire Saint Camille de Ouagadougou, 01 BP 364 Ouagadougou 01, Burkina Faso, Italia.
Karou
Damintoti
D
Nadembega
Wendyame M C
WM
Savadogo
Aly
A
Djeneba
Ouermi
O
Pignatelli
Salvatore
S
Pietra
Virginio
V
Bere
Augustin
A
Simpore
Jacques
J
Traore
Alfred S
AS
D000293:Adolescent; D000328:Adult; D002050:Burkina Faso; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D006679:HIV Seropositivity; D006509:Hepatitis B / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D006566:Herpesviridae Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology*; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D015995:Prevalence