CD44 keeps tumor killers polarized.
In this issue of Immunity, Mrass et al. (2008) report that CD44 critically contributes to the stabilization of polarity in migrating cytotoxic T lymphocytes by anchoring cytoskeletal proteins to the cell membrane at their uropods.
Mempel
Thorsten R
TR
Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. tmempel@mgh.harvard.edu
Marangoni
Francesco
F
D000818:Animals; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism*; D002465:Cell Movement; D016764:Cell Polarity / Q000276:immunology; D003598:Cytoskeletal Proteins / Q000276:immunology / Q000378:metabolism*; D003599:Cytoskeleton / Q000276:immunology / Q000378:metabolism*; D018960:Hyaluronan Receptors / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism
D003598:Cytoskeletal Proteins; D018960:Hyaluronan Receptors