title: [Serum calcium and phosphorus concentration and alkaline phosphatase activity in healthy children during growth and development].
abstract: BACKGROUND
  Many changes happen during growth and development in an organism as a result of important hormon changes, especially biohumoral ones. These changes make a problem when interpreting biochemical results in pediatric population. The most important changes are intensive calcium and phosphorus metabolic turnover in bone tissue with changes in alkaline phosphatase activity as a result of osteoblast activity. The aim of this study was to follow the serum calcium and phosphorus concentration and alkaline phosphatase activity in children 1-15 years old in different growth and development period and of different sexes and to fortify the influence of growth and development dynamics on biohumoral status in healthy male and female children.
  
  
  METHODS
  We evaluated 117 healthy children of both sexes from 1-15 years of age and divided them into three age groups: 1-5, 6-10 and 11-15 years. We followed the serum calcium and phosphorus concentration and alkaline phosphatase activity in different groups and in different sexes.
  
  
  CONCLUSIONS
  Our investigation found significantly higher values of serum calcium in boys than in girls with no important changes between the age groups and significantly higher values of serum phosphorus in the youngest age group in all children and in different sexes with no important sex differences. Alkaline phosphatase activity followed the growth spurt and was the biggest in 6-10 years group in girls and in 11-15 years group in boys.
authors.affiliation: Dom zdravlja Nis, RJ Laboratorijska i rendgen-dijagnostika. sava@bankerinter.net
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Savić
authors.forename: Dejan
authors.initials: D
authors.lastname: Savić
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood*; D002118:Calcium / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D010758:Phosphorus / Q000097:blood*; D012016:Reference Values
chemical_list: D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium