title: [A successful case of advanced nasal adenocarcinoma treated with tumor dormancy therapy with S -1 alone].
abstract: We report a 65-year-old female case of low-grade non-intestinal type adenocarcinoma of the nasal cavity with bilateral metastases to the cervical lymph nodes(T3N2cM0: Stage IV A). Chemoradiotherapy administered as first-line therapy yielded only a partial response in the primary tumor and metastatic lesions, and subsequent chemotherapy with S-1(at a dose of 80 mg per day)alone was applied as tumor dormancy therapy(TDT)on an outpatient basis. Adverse events during S-1 medication were limited to a decrease in leukocyte count and hemoglobin level, both of which were grade 1. The tumor has not enlarged, and the patient has survived 29 months since the beginning of chemotherapy with S-1 alone without any decrease in quality of life. Although the effectiveness of S-1 for adenocarcinoma of the head and neck has not been fully demonstrated, S-1 might be useful in patients with advanced head and neck adenocarcinoma for the purpose of TDT.
authors.affiliation: Dept. of Otolaryngology, Head and Neck Surgery, Osaka City University Graduate School of Medicine, Japan.
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Iguchi
authors.forename: Taichi
authors.initials: T
authors.lastname: Uyama
authors.forename: Akimori
authors.initials: A
authors.lastname: Kanazawa
authors.forename: Hisao
authors.initials: H
authors.lastname: Amatsu
authors.forename: Hideo
authors.initials: H
authors.lastname: Yamane
authors.forename: Makoto
authors.initials: M
authors.lastname: Kusuki
authors.forename: Aki
authors.initials: A
authors.lastname: Nakamura
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018450:Disease Progression; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009669:Nose Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy; D010094:Oxonic Acid / Q000627:therapeutic use*; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid