[Synthesis and cytotoxicity of novel phosphorusless analogues of edelfosine].
Modified series of phosphorusless edelfosine analogues bearing the polar heads of aliphatic bases, N,N-dimethylethanolamine and N,N,N(1),N(1)-tetramethylethylenediamine, were synthesized, with the length of the spacer varying from three to four methylene units. The cytotoxic characteristics of the compounds synthesized were studied.
Romanova
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SG
Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571 Russia. romfill@mail.ru
Shtil'
A A
AA
Serebrennikova
G A
GA
D003642:Deanol / Q000138:chemical synthesis* / Q000737:chemistry; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000737:chemistry; D010742:Phospholipid Ethers / Q000138:chemical synthesis* / Q000737:chemistry
D005029:Ethylenediamines; D010742:Phospholipid Ethers; C005798:N,N,N',N'-tetramethylethylenediamine; C026659:edelfosine; D003642:Deanol