title: [Fluoroquinolones in ophthalmology: mechanisms of action and resistance].
abstract: The arrival of fluoroquinolones in the 1980s aroused enormous enthusiasm in the medical community, justified by the spectrum of antibacterial activity, good tolerance, and wide distribution in tissues, even after oral administration. However, the extensive use of these new antibiotiques finally ended in emerging resistance, which limits the efficiency of all the molecules in the class, including those that have appeared in the last few years. Ocular diseases also benefited from the emergence of fluoroquinolones, notably for topical treatments. It is now mandatory to adapt the prescriptions to the best indications, in order to protect the vast therapeutic potential of these molecules.
authors.affiliation: Service d'Ophtalmologie, CHU Bicêtre, APHP, Université Paris XI, Le Kremlin-Bicêtre.
authors.forename: M
authors.initials: M
authors.lastname: Labetoulle
authors.forename: C
authors.initials: C
authors.lastname: Chiquet
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D001682:Biological Availability; D027101:DNA Topoisomerase IV / Q000037:antagonists & inhibitors; D024901:Drug Resistance, Multiple, Bacterial; D009877:Endophthalmitis / Q000188:drug therapy; D015818:Eye Infections, Bacterial / Q000188:drug therapy*; D024841:Fluoroquinolones / Q000737:chemistry / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy; D006801:Humans; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D024841:Fluoroquinolones; D059005:Topoisomerase II Inhibitors; D027101:DNA Topoisomerase IV