title: Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma.
abstract: OBJECTIVE
  The objective of this study was to compare the clinicopathological features of oral sebaceous hyperplasia and sebaceous adenoma.
  
  
  METHODS
  Clinical data, microscopical characteristics, and ki-67 immunoexpression were comparatively analyzed on 2 intraoral sebaceous adenomas, 6 intraoral sebaceous hyperplasias, and 21 normal intraoral sebaceous glands.
  
  
  RESULTS
  Clinically, sebaceous glands presented as multiple separated papules, sebaceous hyperplasias as a single enlarged papule, and sebaceous adenoma as a well-defined nodule. Microscopically, sebaceous adenoma presented an increased number of lobules, smaller lobules, and a greater number of germinative/squamous cells. Sebaceous hyperplasia also had an increased number of lobules and fewer number of germinative/squamous cells, as compared to normal oral sebaceous glands. Ki-67 expression was seen only in germinative cells and counts were higher in sebaceous adenomas followed by hyperplasias and normal glands.
  
  
  CONCLUSIONS
  Sebaceous hyperplasias and adenomas showed different clinical, microscopic, and proliferative characteristics, suggesting the usefulness of the studied criteria on diagnosis of these uncommon oral lesions.
authors.affiliation: Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, Piracicaba/SP, Brazil.
authors.forename: Rebeca Souza
authors.initials: RS
authors.lastname: Azevedo
authors.forename: Oslei Paes
authors.initials: OP
authors.lastname: Almeida
authors.forename: Juliana Noronha Santos
authors.initials: JN
authors.lastname: Netto
authors.forename: Aguida Maria Menezes Aguiar
authors.initials: AM
authors.lastname: Miranda
authors.forename: Teresa Cristina Ribeiro Bartholomeu
authors.initials: TC
authors.lastname: Santos
authors.forename: Ricardo
authors.initials: R
authors.lastname: Della Coletta
authors.forename: Márcio Ajudarte
authors.initials: MA
authors.lastname: Lopes
authors.forename: Fábio Ramôa
authors.initials: FR
authors.lastname: Pires
mesh_terms: D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D012625:Sebaceous Gland Diseases / Q000473:pathology*; D012626:Sebaceous Gland Neoplasms / Q000473:pathology*; D012627:Sebaceous Glands / Q000473:pathology*; D055815:Young Adult
chemical_list: D019394:Ki-67 Antigen