Androgen receptor expression patterns in Becker's nevi: an immunohistochemical study.
BACKGROUND
Becker's nevus (BN) is a hyperpigmented patch that traditionally presents on the upper torso in adolescent males. Previous studies have reported an association with increased androgen receptors (ARs) in lesional skin in men and women who have associated physical abnormalities.


OBJECTIVE
This study was conducted to assess the presence of ARs immunohistochemically in female patients with BN but no other physical abnormalities and compare this finding with BN in males and in normal skin.


METHODS
Biopsy specimens from Becker's nevi in 3 women and 3 men as well as normal skin in the 3 female subjects were stained with AR antibody, and the level of expression in various cutaneous structures was measured.


RESULTS
ARs were increased in dermal fibroblasts in Becker's nevi compared to that found in normal skin.


CONCLUSIONS
The major limitation of the study was the small sample size.


CONCLUSIONS
In BN there is increased AR expression in dermal fibroblasts; immunohistochemical staining may aid in making the biopsy diagnosis.
Grande Sarpa
Hege
H
Department of Dermatology, University of Utah, Salt Lake City, Utah 84132, USA. Hege.Sarpa@hsc.utah.edu
Harris
Ronald
R
Hansen
C David
CD
Callis Duffin
Kristina P
KP
Florell
Scott R
SR
Hadley
Michael L
ML
D000293:Adolescent; D000328:Adult; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009508:Nevus, Pigmented / Q000378:metabolism* / Q000473:pathology; D011944:Receptors, Androgen / Q000096:biosynthesis*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology
D011944:Receptors, Androgen