Obstructive coronary artery disease in high-risk diabetic patients with and without atrial fibrillation.
OBJECTIVE
To investigate the severity of coronary artery disease by coronary angiography in age-matched and sex-matched patients with diabetes mellitus with atrial fibrillation versus sinus rhythm.


METHODS
The patients included 245 men and women, mean age of 70 years, with diabetes and atrial fibrillation and 245 age-matched and sex-matched patients with diabetes and sinus rhythm who underwent coronary angiography. Baseline characteristics and indications for coronary angiography were similar in both groups.


RESULTS
Greater than 50% narrowing of one, two, or three major coronary arteries were present in 229 of 245 patients (94%) with diabetes and atrial fibrillation and in 211 of 245 patients (86%) with diabetes and with sinus rhythm (P<0.01). Greater than 50% narrowing of three major coronary arteries were present in 150 of 245 patients (61%) with diabetes and atrial fibrillation and in 75 of 245 patients (31%) with diabetes and sinus rhythm (P<0.001).


CONCLUSIONS
Patients with diabetes and atrial fibrillation have a significantly higher prevalence of greater than 50% narrowing of one or more major coronary arteries and of three major coronary arteries than patients with diabetes and sinus rhythm.
Pierre-Louis
Bredy
B
Department of Medicine, Cardiology Division, New York Medical College, Valhalla, New York 10595, USA.
Aronow
Wilbert S
WS
Palaniswamy
Chandrasekar
C
Singh
Tarunjit
T
Weiss
Melvin B
MB
Kalapatapu
Kumar
K
Pucillo
Anthony L
AL
Monsen
Craig E
CE
D000368:Aged; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D016022:Case-Control Studies; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D048909:Diabetes Complications / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index