title: Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women.
abstract: BACKGROUND
  Adiponectin has been reported as a new risk factor for the development of diabetes. However, it is not clear whether adiponectin levels are associated with family history of diabetes (FHD).
  
  
  OBJECTIVE
  The objective of this study was to measure the independent association of serum adiponectin with FHD in relation to insulin resistance and obesity.
  
  
  METHODS
  In 2006, a cross-sectional study was conducted in which waist circumference (WC), body mass index (BMI), and serum adiponectin were measured in 5919 healthy Korean men and women. Multiple linear regression models were used to assess the association of serum adiponectin levels with FHD. The population was classified into two groups according to median values for each of the following variables: WC, BMI, and homeostasis model assessment of insulin resistance (HOMA-IR).
  
  
  RESULTS
  The positive FHD group had higher HOMA-IR and lower adiponectin levels in both men and women than those without FHD. Adiponectin levels were significantly associated with FHD in men and women respectively, after adjusting for age, BMI, and alcohol consumption (P=0.0123 and 0.0004). The relationship between adiponectin and FHD was similar between the high and low insulin resistance, BMI, and WC groups in male non-smokers and in all Korean women.
  
  
  CONCLUSIONS
  These results confirm that adiponectin levels are associated with FHD. These data also suggest that the association of serum adiponectin with FHD may be independent of obesity and insulin resistance.
authors.affiliation: Graduate School of Public Health, Institute for Health Promotion, Yonsei University, Seoul, Republic of Korea.
authors.forename: Jae Woong
authors.initials: JW
authors.lastname: Sull
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Yun
authors.forename: Grace
authors.initials: G
authors.lastname: Kim
authors.forename: Eun Jung
authors.initials: EJ
authors.lastname: Park
authors.forename: Soriul
authors.initials: S
authors.lastname: Kim
authors.forename: Hee Yeon
authors.initials: HY
authors.lastname: Lee
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Jee
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007723:Korea; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol