Optical ensemble analysis of intraocular lens performance through a simulated clinical trial with ZEMAX.
A ZEMAX model was constructed to simulate a clinical trial of intraocular lenses (IOLs) based on a clinically oriented Monte Carlo ensemble analysis using postoperative ocular parameters. The purpose of this model is to test the feasibility of streamlining and optimizing both the design process and the clinical testing of IOLs. This optical ensemble analysis (OEA) is also validated. Simulated pseudophakic eyes were generated by using the tolerancing and programming features of ZEMAX optical design software. OEA methodology was verified by demonstrating that the results of clinical performance simulations were consistent with previously published clinical performance data using the same types of IOLs. From these results we conclude that the OEA method can objectively simulate the potential clinical trial performance of IOLs.
Zhao
Huawei
H
Advanced Medical Optics, Santa Ana, CA 92705-4933, USA. huawei.zhao@amo-inc.com
D002986:Clinical Trials as Topic; D003198:Computer Simulation; D007910:Lenses, Intraocular; D009010:Monte Carlo Method; D055095:Optics and Photonics