title: Acute retinal necrosis in primary herpes simplex virus type I infection.
abstract: Here we report the case of an immunocompetent 8-year-old child who developed acute retinal necrosis concomitant with a primary herpes simplex virus type I infection. Ocular inflammation changed along with the development of a specific antibody titer in the serum. This evidence suggests that the immune response of the host can significantly modulate the clinical aspect of the ocular infection.
authors.affiliation: Institute of Ophthalmology, University of Parma, Parma, Italy. paolo.mora@unipr.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Mora
authors.forename: Yan
authors.initials: Y
authors.lastname: Guex-Crosier
authors.forename: Erilda
authors.initials: E
authors.lastname: Kamberi
authors.forename: Jelka G
authors.initials: JG
authors.lastname: Orsoni
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000867:Anterior Chamber / Q000473:pathology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D005654:Fundus Oculi; D006561:Herpes Simplex / Q000150:complications*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007121:Immunocompetence; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012160:Retina / Q000473:pathology / Q000821:virology; D015882:Retinal Necrosis Syndrome, Acute / Q000150:complications* / Q000821:virology*
chemical_list: D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D011241:Prednisone; D000212:Acyclovir