Severe cutaneous adverse drug reaction due to fluconazole.
Fluconazole is a rare cause of severe cutaneous adverse drug reactions. A case of a diffuse, exfoliative eruption due to fluconazole is presented. Convincing arguments for a diagnosis of both widespread bullous fixed drug eruption and toxic epidermal necrolysis are made. The clinical presentation, diagnosis, and differentiation of these 2 severe cutaneous acute drug reactions are discussed.
Lester
Laura J Umstattd
LJ
Baylor College of Medicine, Department of Internal Medicine, Houston, TX, USA.
Brantley
Julie S
JS
Kelso
Rebecca L
RL
Kelly
Brent C
BC
Petitt
Mathew S
MS
Wilkerson
Michael G
MG
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D002180:Candidiasis, Oral / Q000188:drug therapy; D003937:Diagnosis, Differential; D003875:Drug Eruptions / Q000473:pathology*; D005260:Female; D015725:Fluconazole / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D012867:Skin / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000473:pathology
D000935:Antifungal Agents; D015725:Fluconazole