Retrospective evaluation of biopsychosocial determinants and treatment response in patients receiving devil's claw extract (doloteffin).
In a retrospective evaluation of patients taking part for 2 months in a postmarketing surveillance study on the effectiveness and safety of Harpagophytum procumbens, associations were found to known explanators of pain, disability and depression. Therefore, treatment non-responders might best be referred to a multimodal pain relief program that deals with fear avoidance beliefs, enhances experiences that decrease perceptions linking disability and pain and forces the patients to rethink the way they deal with the problem. However, during treatment with the aqueous Harpagophytum extract, this decision might reasonably be postponed to the end of month 4, since it has been shown that the maximum pain relief occurs after 3-4 months.
Thanner
J
J
Institute of Communication Medicine, University of Greiswald, Greifswald, Germany.
Kohlmann
Th
T
Künzel
O
O
Chrubasik
S
S
D000223:Adaptation, Psychological; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D003863:Depression / Q000523:psychology; D004341:Drug Evaluation; D005239:Fear; D005260:Female; D031684:Harpagophytum / Q000737:chemistry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000523:psychology*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012189:Retrospective Studies; D016896:Treatment Outcome
D000700:Analgesics; C469611:Doloteffin; D010936:Plant Extracts