Phototocatalytic lithography of poly(propylene sulfide) block copolymers: toward high-throughput nanolithography for biomolecular arraying applications.
Photocatalytic lithography (PCL) is an inexpensive, fast, and robust method of oxidizing surface chemical moieties to produce patterned substrates. This technique has utility in basic biological research as well as various biochip applications. We report on porphyrin-based PCL for patterning poly(propylene sulfide) block copolymer films on gold substrates on the micrometer and submicrometer scales. We confirm chemical patterning with imaging ToF-SIMS and low-voltage SEM. Biomolecular patterning on micrometer and submicrometer scales is demonstrated with proteins, protein-linked beads. and fluorescently labeled proteins.
Bearinger
Jane P
JP
Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory L-211, 7000 East Avenue, Livermore, California, USA. bearinger1@llnl.gov
Stone
Gary
G
Hiddessen
Amy L
AL
Dugan
Lawrence C
LC
Wu
Ligang
L
Hailey
Philip
P
Conway
James W
JW
Kuenzler
Tobias
T
Feller
Lydia
L
Cerritelli
Simona
S
Hubbell
Jeffrey A
JA
D000327:Adsorption; D002384:Catalysis; D006046:Gold / Q000737:chemistry; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D010777:Photochemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry; D040081:Protein Array Analysis / Q000379:methods*; D018629:Spectrometry, Mass, Secondary Ion; D019809:Streptavidin / Q000737:chemistry; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
D008567:Membranes, Artificial; D011166:Porphyrins; D013440:Sulfides; C515871:poly(ethylene glycol)-stabilized poly(propylene sulfide); D011092:Polyethylene Glycols; D006046:Gold; D019809:Streptavidin