Evolution of central nervous system multidrug-resistant Mycobacterium tuberculosis and late relapse of cryptic prosthetic hip joint tuberculosis: complications during treatment of disseminated isoniazid-resistant tuberculosis in an immunocompromised host.
We report a case of disseminated isoniazid-resistant tuberculosis in an immunocompromised patient with evolution of rifampin (rifampicin) resistance in the central nervous system. This was cured with intraventricular and oral treatment but was followed by a late relapse of the original infection in a prosthetic hip joint. We provide drug levels in cerebrospinal fluid and serum.
Upton
Arlo
A
Clinical Microbiology, Auckland City Hospital, Auckland, New Zealand.
Woodhouse
Andrew
A
Vaughan
Ross
R
Newton
Sandie
S
Ellis-Pegler
Rod
R
D000328:Adult; D000995:Antitubercular Agents / Q000032:analysis / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000737:chemistry; D006621:Hip Joint / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification*; D016459:Prosthesis-Related Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D012008:Recurrence; D044967:Serum / Q000737:chemistry; D014390:Tuberculosis, Meningeal / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*
D000995:Antitubercular Agents