title: [Fabrication and characteristics of oriental poly (lactic-co-glycolic acid) scaffold: a preliminary study].
abstract: OBJECTIVE
  To explore the method of fabricating oriental scaffolds and investigate the biocompatibility of the scaffolds as well as cells distribution within the scaffolds in vitro.
  
  
  METHODS
  The oriental poly (lactic-co-glycolic acid) (PLGA) scaffolds were fabricated with modified emulsion-phase separation method. The scaffolds were treated with plasma and then anchored with collagen I. Articular chondrocytes were loaded into the scaffolds. The growth status and distributing characteristic of the cells were investigated by environmental scanning electron microscope.
  
  
  RESULTS
  The scaffold was well compatible with the articular chondrocytes. The cells could reach to 2.5 mm depth with unilateral loading. The cells distributed evenly in the scaffold and lined along the inner pipes.
  
  
  CONCLUSIONS
  The oriental scaffold fabricated could significantly promote the distributing characteristics of the chondrocytes. The vertical alignment of the chondrocytes within the scaffold is closely similar to that of articular cartilage.
authors.affiliation: Orthopedics Institute, General Hospital of People's Liberation Army, Beijing 100853, China.
authors.forename: Fang-yuan
authors.initials: FY
authors.lastname: Yu
authors.forename: Shi-bi
authors.initials: SB
authors.lastname: Lu
authors.forename: Shen-guo
authors.initials: SG
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhao
authors.forename: Jian-zhong
authors.initials: JZ
authors.lastname: Bei
authors.forename: Wen-jing
authors.initials: WJ
authors.lastname: Xu
authors.forename: Mei
authors.initials: M
authors.lastname: Yuan
mesh_terms: D002358:Cartilage, Articular / Q000166:cytology*; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology; D006016:Glycolates; D006801:Humans; D019344:Lactic Acid; D008422:Materials Testing; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D054457:Tissue Scaffolds
chemical_list: D006016:Glycolates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid