title: Enantioselective sequential conjugate addition-allylation reactions: a concise total synthesis of (+)-podophyllotoxin.
abstract: A highly flexible and concise total synthesis of (+)-podophyllotoxin featured with an enantioselective sequential conjugate addition-allylation reaction was reported. Starting from commercially available 3,4,5-trimethoxycinnamic acid, this new route leads to (+)-podophyllotoxin 1 in only eight steps with 29% overall yield.
authors.affiliation: Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, Yunnan 650091, PR China.
authors.forename: Yingming
authors.initials: Y
authors.lastname: Wu
authors.forename: Jingfeng
authors.initials: J
authors.lastname: Zhao
authors.forename: Jingbo
authors.initials: J
authors.lastname: Chen
authors.forename: Chengxue
authors.initials: C
authors.lastname: Pan
authors.forename: Liang
authors.initials: L
authors.lastname: Li
authors.forename: Hongbin
authors.initials: H
authors.lastname: Zhang
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002934:Cinnamates / Q000737:chemistry*; D015394:Molecular Structure; D011034:Podophyllotoxin / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D002934:Cinnamates; C031619:3,4,5-trimethoxycinnamic acid; D011034:Podophyllotoxin