title: Cytogenetic analysis in childhood acute lymphoblastic leukemia: experience at a single institution in Korea.
abstract: We evaluated major cytogenetic abnormalities associated with childhood acute lymphoblastic leukemia (ALL) through both fluorescent in situ hybridization and conventional chromosomal analysis for 132 ALL patients diagnosed at St Mary's Hospital in Korea. Chromosome abnormalities have been detected in 92% of patients. Eighteen (14%) patients showed numerical abnormalities only, 50 (38%) patients showed structural abnormalities only, and 53 (40%) patients showed both. The simultaneous trisomies 4, 10 and 17 were observed in 23 (17%) patients. Of the patients with abnormal karyotypes, recurrent structural abnormalities were determined in 103 (78%) cases. t(12;21)(q13;q22) was found in 29 (22%) out of 132 patients, 9p abnormalities in 13 (10%) patients, t(1;19)(q23;p13.3) in 11 (8%) patients, t(9;22)(q34;q11.2) in 11 (8%) patients, and 11q23 abnormalities in 7 (5%) patients. Interestingly, we identified five uncommon translocations such as t(5;12) (q33;p13), t(14;19)(q32;q13.1), t(12;16)(p13;q13), der(1)t(1;12)(p32;p13), and t(5;15)(p15;q11.2). Our study pool is representative of pediatric ALL patients in Korea as it consists of about 20% of patients diagnosed annually in Korea. We believe that the data provided will aid in comparative studies of the treatment outcomes, as well as the type and incidence of chromosomal abnormalities associated with childhood ALL in various Asian nations and Western countries.
authors.affiliation: Pediatric Hematology-Oncology Clinic, Center for Specific Organs Cancer, National Cancer Center, Goyang, South Korea.
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Kwon
authors.affiliation: Department of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
authors.forename: Jae Wook
authors.initials: JW
authors.lastname: Lee
authors.affiliation: Department of Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Myung Shin
authors.initials: MS
authors.lastname: Kim
authors.affiliation: Department of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
authors.forename: Pil Sang
authors.initials: PS
authors.lastname: Jang
authors.affiliation: Department of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
authors.forename: Nak Gyun
authors.initials: NG
authors.lastname: Chung
authors.affiliation: Department of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
authors.forename: Dae Chul
authors.initials: DC
authors.lastname: Jeong
authors.affiliation: Department of Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Yong Goo
authors.initials: YG
authors.lastname: Kim
authors.affiliation: Department of Laboratory Medicine, The Catholic University of Korea, Seoul, South Korea.
authors.forename: Kyung Ja
authors.initials: KJ
authors.lastname: Han
authors.affiliation: Department of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
authors.forename: Soon Ju
authors.initials: SJ
authors.lastname: Lee
authors.affiliation: Department of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea. chobinkr@catholic.ac.kr.
authors.forename: Bin
authors.initials: B
authors.lastname: Cho
authors.affiliation: Department of Pediatrics, St Mary's Hospital, The Catholic University of Korea, #62, Yeoudo-dong, Yeongdeungpo-gu, Seoul, 150-713, South Korea.
authors.forename: Hack Ki
authors.initials: HK
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007223:Infant; D007723:Korea / Q000453:epidemiology; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000453:epidemiology / Q000235:genetics*