Urticaria pigmentosa associated with acute stress and lesional skin mast-cell expression of CRF-R1.
A 38-year-old woman presented with a pronounced increase in symptoms and proliferation of urticaria pigmentosa (UP) after acute psychological stress, which was quantified using the Spielberger's State-Trait Anxiety Inventory. Immunohistochemical examination of a skin biopsy from a new UP lesion showed a large number of activated mast cells expressing corticotrophin-releasing factor receptor-1 (CRF-R1) and there was high serum CRF. This is the first documented report to our knowledge of UP worsening associated with acute stress, possibly through activation of skin mast-cell CRF-R1.
Theoharides
T C
TC
Department of Pharmacology, Tufts University School of Medicine, Tufts Medical Center, Boston, MA 02111, USA. theoharis.theoharides@tufts.edu
Kempuraj
D
D
Marchand
J
J
Tzianoumis
L
L
Vasiadi
M
M
Katsarou-Katsari
A
A
Makris
M
M
Kalogeromitros
D
D
D000208:Acute Disease; D000328:Adult; D005260:Female; D006801:Humans; D008407:Mast Cells / Q000378:metabolism*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000378:metabolism*; D012867:Skin / Q000378:metabolism*; D013315:Stress, Psychological / Q000150:complications*; D014582:Urticaria Pigmentosa / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D000099052:CRF Receptor, Type 1
D018019:Receptors, Corticotropin-Releasing Hormone; D000099052:CRF Receptor, Type 1