[Advantages of corticosteroids in managing acute bacterial postoperative endophthalmitis].
Most studies show a trend toward a beneficial or at least neutral effect of associating corticosteroids and antibiotics. However, caution must be taken, with various factors considered: the type, virulence, and size of the inoculum, and the treatment chosen. Early intravitreal administration of 400 microg of dexamethasone seems to be beneficial in treating postoperative Staphylococcus epidermidis-related endophthalmitis. However, a large-scale prospective, randomized, controlled study is mandatory to gain evidence supporting steroid therapy in postoperative endophthalmitis.
Saleh
M
M
Service d'Ophtalmologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg. Université Louis- Pasteur, Strasbourg I.
Jehl
F
F
Prevost
G
G
Speeg-Schatz
C
C
Bourcier
T
T
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016207:Cytokines / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D006801:Humans; D007267:Injections; D051379:Mice; D008954:Models, Biological; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012163:Retinal Detachment / Q000209:etiology / Q000517:prevention & control; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D016207:Cytokines