title: Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?
abstract: Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Wan Beom
authors.initials: WB
authors.lastname: Park
authors.forename: Pyoeng Gyun
authors.initials: PG
authors.lastname: Choe
authors.forename: Kyoung-Ho
authors.initials: KH
authors.lastname: Song
authors.forename: Shinwon
authors.initials: S
authors.lastname: Lee
authors.forename: Hee-Chang
authors.initials: HC
authors.lastname: Jang
authors.forename: Jae Hyun
authors.initials: JH
authors.lastname: Jeon
authors.forename: Sang-Won
authors.initials: SW
authors.lastname: Park
authors.forename: Myoung Hee
authors.initials: MH
authors.lastname: Park
authors.forename: Myoung-don
authors.initials: MD
authors.lastname: Oh
authors.forename: Kang Won
authors.initials: KW
authors.lastname: Choe
mesh_terms: D000328:Adult; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D005820:Genetic Testing; D015658:HIV Infections / Q000188:drug therapy*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D000099227:Abacavir
chemical_list: D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen