title: Asymmetric dimethylarginine levels and carotid intima-media thickness in obese patients with polycystic ovary syndrome and their relationship to metabolic parameters.
abstract: OBJECTIVE
  To evaluate the plasma asymmetric dimethyl arginine (ADMA) levels and carotid intima-media thickness (IMT) in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  Thirty-five patients with PCOS and 31 healthy controls.
  
  
  METHODS
  Peripheral venous puncture, ultrasonography, oral glucose tolerance test (OGTT).
  
  
  METHODS
  Plasma ADMA, serum FSH, LH, dehydroepiandrosterone sulfate (DHEAS), free T and total T, insulin, fasting plasma glucose, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglyceride, homocysteine, fibrinogen, C-reactive protein, and carotid IMT.
  
  
  RESULTS
  The PCOS group had higher levels of androgens, triglycerides, homocysteine, insulin, and homeostasis model assessment of insulin resistance when compared with controls. There were no significant differences in ADMA levels and IMT between the two groups. The fasting plasma glucose, total cholesterol, HDL cholesterol, LDL cholesterol, fibrinogen, and C-reactive protein levels were not different among the groups. Intima-media thickness was significantly correlated with DHEAS, but there was no association between IMT and ADMA.
  
  
  CONCLUSIONS
  Results of our study revealed that ADMA levels and carotid IMT in patients with PCOS are not different from healthy controls.
authors.affiliation: Department of Internal Medicine, Division of Endocrinology and Metabolism, Baskent University, School of Medicine, 5th street, 48, Bahcelievler, 06490 Ankara, Turkey. bopamuk@gmail.com
authors.forename: Baris Onder
authors.initials: BO
authors.lastname: Pamuk
authors.forename: Ayse Nur
authors.initials: AN
authors.lastname: Torun
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kulaksizoglu
authors.forename: Derun
authors.initials: D
authors.lastname: Ertugrul
authors.forename: Ozgur
authors.initials: O
authors.lastname: Ciftci
authors.forename: Sevsen
authors.initials: S
authors.lastname: Kulaksizoglu
authors.forename: Erkan
authors.initials: E
authors.lastname: Yildirim
authors.forename: Nilgun Guvener
authors.initials: NG
authors.lastname: Demirag
mesh_terms: D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D009765:Obesity / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000000981:diagnostic imaging / Q000378:metabolism; D011446:Prospective Studies; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D017540:Tunica Media / Q000000981:diagnostic imaging*; D014463:Ultrasonography; D055815:Young Adult
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine