title: [The future of loco-regional treatment for advanced gastric cancer].
abstract: We have evaluated the result of neo-adjuvant chemotherapy for advanced gastric cancer to estimate the future of loco- regional therapy. Twenty patients with advanced gastric cancer accepted 2 courses of neo-adjuvant chemotherapy with S- 1 and cisplatin. In 13 patients (52%), chemotherapy could successfully control the growth of tumor. Thirteen patients with curative resection demonstrated a better survival (MST 682 days) than 12 patients with non-curative resection (MST 377 days). Neo-adjuvant chemotherapy using S-1 and cisplatin was an effective treatment for advanced gastric cancer. However, no survival benefit could be obtained for patients with non-curative resection. Administration of loco-regional treatment, such as intra peritoneal paclitaxel, should be considered for those cases with positive peritoneal cytology.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Toshima Hospital.
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagahama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ando
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ganno
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ami
authors.forename: Akira
authors.initials: A
authors.lastname: Fukuda
authors.forename: Michio
authors.initials: M
authors.lastname: Maruyama
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin