Neural patterning and CNS functions of Wnt in zebrafish.
Wnt signaling plays several important roles in the development of the zebrafish central nervous system (CNS). This chapter outlines both the known and postulated roles of Wnts from the earliest step of neural plate induction to relatively late events such as axon pathfinding and synaptogenesis. The common tools useful for examining Wnt function and nervous system development in zebrafish are first reviewed. Examples are then provided for specific phenotypes resulting from gain and loss of Wnt activity at multiple developmental stages. Finally, specific assays and reagents that can be used to investigate the function of novel Wnt pathway components in CNS development are listed.
Dorsky
Richard I
RI
Department of Neurobiology and Anatomy, University of Utah, Salt Lake City, UT, USA.
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002454:Cell Differentiation; D002490:Central Nervous System / Q000033:anatomy & histology / Q000196:embryology* / Q000502:physiology*; D004627:Embryonic Induction / Q000502:physiology; D009024:Morphogenesis / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010641:Phenotype; D015398:Signal Transduction / Q000502:physiology; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D015027:Zebrafish / Q000033:anatomy & histology* / Q000196:embryology* / Q000502:physiology; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
D051153:Wnt Proteins; D029961:Zebrafish Proteins