[Protective role of cobalt complexes of porphyrin and phthalocyanine in acute nitrite intoxication and endotoxic shock in an experiment].
There is currently an active search for effective agents to regulate the content of nitric oxide (NO) in the body. One of the ways of reducing its blood concentration may be the binding of NO by different complexions that comprise the metal complexes of porphyrins and phthalocyanines. The study was undertaken to evaluate the protective effect of synthetic metal complexes of porphyrin and phthalocyanine in acute nitrite intoxication and endotoxic shock. The findings suggest that both study samples of the synthetic metal complexes have not prevented hemolytic anemia in acute nitrite intoxication and endotoxic shock; however, they have shown potential sorption properties against nitrate ions in the blood and brain of experimental animals, which may be the subject of a further study.
Pakhrova
O A
OA
Tomilova
I K
IK
Aleksakhina
E L
EL
Ivanova
A S
AS
Gorbunov
V A
VA
Nazarov
S B
SB
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D054833:Isoindoles; D008297:Male; D009573:Nitrites / Q000633:toxicity*; D011524:Protoporphyrins / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012772:Shock, Septic / Q000139:chemically induced / Q000517:prevention & control*; D016896:Treatment Outcome
D007211:Indoles; D054833:Isoindoles; D009573:Nitrites; D011524:Protoporphyrins; D011838:Radiation-Sensitizing Agents; C007095:cobaltiprotoporphyrin; C013647:phthalocyanine