title: Gene delivery systems for gene therapy in tissue engineering and central nervous system applications.
abstract: The present review aims to describe the potential applications of gene delivery systems to tissue engineering and central nervous system diseases. Some key experimental work has been done with interesting results, but the subject is far from being fully explored. The combined approach of gene therapy and material science has a huge potential to improve the therapeutic approaches now available for a wide range of medical applications. Focus is given to this multidisciplinary strategy in neurodegenerative pathologies, where the use of polymeric matrices as gene carriers might make a crucial difference.
authors.affiliation: Department of Chemistry, Materials and Chemical Engineering G. Natta, Politecnico di Milano, Milano, Italy. carmen.giordano@polimi.it
authors.forename: C
authors.initials: C
authors.lastname: Giordano
authors.forename: F
authors.initials: F
authors.lastname: Causa
authors.forename: F
authors.initials: F
authors.lastname: Bianco
authors.forename: G
authors.initials: G
authors.lastname: Perale
authors.forename: P A
authors.initials: PA
authors.lastname: Netti
authors.forename: L
authors.initials: L
authors.lastname: Ambrosio
authors.forename: A
authors.initials: A
authors.lastname: Cigada
mesh_terms: D001672:Biocompatible Materials; D002493:Central Nervous System Diseases / Q000628:therapy*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D011108:Polymers; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D011108:Polymers