title: Prosthetic carotid bypass grafts for atherosclerotic lesions: a prospective study of 198 consecutive cases.
abstract: OBJECTIVE
  Carotid endarterectomy (CEA) is the standard treatment for atherosclerotic lesions involving the carotid bifurcation. However, CEA can be challenging under some conditions. The goal of this study was to determine the outcome and durability of prosthetic carotid bypass grafting (PCB) with polytetrafluoroethylene (PTFE) grafts as an alternative to CEA.
  
  
  METHODS
  This is a prospective series of 198 consecutive patients with PCB, representing 12.4% of 1595 patients with a carotid reconstruction procedure performed in our department between September 1986 and December 2006. Qualifying event was stroke in 67 patients (34%) and transient ischaemic attack (TIA) in 45 (23%), and 86 patients (43%) were asymptomatic. Primary indications for PCB were extensive atherosclerotic lesions (n=71; 36%), carotid stenosis associated with kinking (n=49; 25%), recurrent stenosis (n=47; 23%), stenosis after radiation therapy (n=18; 9%) and technical failure of CEA (n=13; 7%), with excessive arterial wall thinning and perforation after endarterectomy (n=10) or intimal flap on completion digital angiography (n=3).
  
  
  RESULTS
  The combined stroke and death rate at 30 days were 0.5% (one stroke). Median follow-up was 9.5 years (interquartile range (IQR): 6.2-18.3 years). At 10 years, primary patency was 97.9+/-3.4%. Six PCBs (3.0%) became occluded during follow-up; one patient had a restenosis greater than 50% and 18 patients (9.1%) had a restenosis of less than 50%. Five patients had an ipsilateral stroke (one postoperative stroke, one at 103 days with a patent PCB and three related to occlusion of the PCB at 4, 13 and 15 years after the procedure). At 10 years, cumulative stroke-free survival was 98.4+/-3.2%, and cumulative survival was 78.8+/-7.0%.
  
  
  CONCLUSIONS
  PCB is a safe surgical alternative and is durable, with a low incidence of graft restenosis, when CEA seems hazardous.
authors.affiliation: Vascular Surgery Department, Jean Bernard University Hospital, 86021, Poitiers, France. jeanbaptiste.ricco@orange.fr
authors.forename: J B
authors.initials: JB
authors.lastname: Ricco
authors.forename: C
authors.initials: C
authors.lastname: Marchand
authors.forename: J P
authors.initials: JP
authors.lastname: Neau
authors.forename: E
authors.initials: E
authors.lastname: Marchand
authors.forename: J
authors.initials: J
authors.lastname: Cau
authors.forename: G
authors.initials: G
authors.lastname: Fébrer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000401:mortality / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D002339:Carotid Arteries / Q000601:surgery; D016893:Carotid Stenosis / Q000401:mortality / Q000601:surgery*; D016894:Endarterectomy, Carotid; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications; D011446:Prospective Studies; D012008:Recurrence; D020521:Stroke / Q000453:epidemiology; D016019:Survival Analysis; D014654:Vascular Patency
chemical_list: D011138:Polytetrafluoroethylene