title: Disease presentation and outcome in very young patients with brain metastases from breast cancer.
abstract: OBJECTIVE
  Little information is available on disease presentation and treatment outcome in very young patients with brain metastases from breast cancer. Therefore, we evaluated our results in this group.
  
  
  METHODS
  In our database, 7/74 breast cancer patients treated for brain metastases were < 40 years old. All received whole-brain radiation therapy plus individual local or systemic measures.
  
  
  RESULTS
  In patients with information available, tumors were poorly differentiated and metastatic to the axillary lymph nodes at primary diagnosis. All patients had extracranial metastases. Two died from their brain disease within 5 months. Five patients died from extracranial progression after 3-84 months (2 long-term survivors beyond 2 years, characterized by single brain lesions and high performance status).
  
  
  CONCLUSIONS
  Very young patients did not achieve a better outcome than intermediate age groups. Whole-brain radiation therapy plus surgery or radiosurgery provided durable CNS control in most of the patients. Improved systemic therapy appears to represent the key to a better outcome.
authors.affiliation: Radiation Oncology Unit, Department of Internal Medicine, Nordlandssykehuset HF, Bodø, Norway. carsten.nieder@nlsh.no
authors.forename: Carsten
authors.initials: C
authors.lastname: Nieder
authors.forename: Sabrina T
authors.initials: ST
authors.lastname: Astner
authors.forename: Nicolaus H
authors.initials: NH
authors.lastname: Andratschke
authors.forename: Markus
authors.initials: M
authors.lastname: Adam
mesh_terms: D000328:Adult; D001365:Axilla; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy*; D016371:Cranial Irradiation; D005260:Female; D006801:Humans; D017567:Karnofsky Performance Status; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D016634:Radiosurgery; D012189:Retrospective Studies; D016896:Treatment Outcome