title: Epidemiologically linked transmission of HIV-1 illustrates the impact of host genetics on virological outcome.
abstract: The diversity of HIV-1 and human genetics complicates our ability to determine the impact of treatment during primary HIV-1 infection on disease outcome. Here, we show, in a small group infected with virtually identical HIV-1 strains and treated during primary HIV-1 infection, that patients expressing protective human leucocyte antigen alleles had lower viral loads following treatment discontinuation. These data suggest that genetic factors play an important role in the outcome of HIV-1 infection despite early therapy.
authors.affiliation: Partners AIDS Research Center, Division of Infectious Diseases, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Streeck
authors.forename: Heiko
authors.initials: H
authors.lastname: Jessen
authors.forename: Claudia
authors.initials: C
authors.lastname: Kuecherer
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Arne B
authors.initials: AB
authors.lastname: Jessen
authors.forename: Stephan
authors.initials: S
authors.lastname: Dupke
authors.forename: Axel
authors.initials: A
authors.lastname: Baumgarten
authors.forename: Ingrid
authors.initials: I
authors.lastname: Stahmer
authors.forename: Jan
authors.initials: J
authors.lastname: van Lunzen
authors.forename: Marcus
authors.initials: M
authors.lastname: Altfeld
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005858:Germany / Q000453:epidemiology; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006650:Histocompatibility Testing; D006801:Humans; D019562:Viral Load