Why eating less keeps mitochondria working in aged skeletal muscle.
The mechanisms by which caloric restriction preserves skeletal muscle health with aging continue to be explored; however, mounting evidence points toward a convergence of effects at the level of the mitochondrion. Specifically, caloric restriction reduces mitochondrial reactive oxygen species production and promotes mitochondrial renewal via enhanced drive on mitochondrial biogenesis and autophagy.
Hepple
Russell T
RT
Faculty of Kinesiology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada. hepple@ucalgary.ca
D000375:Aging / Q000502:physiology*; D000818:Animals; D001343:Autophagy; D031204:Caloric Restriction; D006801:Humans; D008931:Mitochondria, Muscle / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species