title: [A case of peritonitis carcinomatosa from goblet cell carcinoid of the appendix treated by intraperitoneal paclitaxel and systemic S-1 chemotherapy].
abstract: Goblet cell carcinoid of the appendix is a rare neoplasm and clinically tends to take a malignant course. Most cases are young and early stage, and the surgical strategy is available. But appropriate chemotherapy for inoperable cases with peritoneal dissemination is not established. A 77-year-old woman with a past history of appendectomy was admitted to our hospital complaining of abdominal fullness. Abdominal computed tomography showed massive ascites and slight contrast enhancement of appendix. A tumor was found by colonoscopic examination at the orifice of vermiform and was diagnosed pathologically as goblet cell carcinoid of the appendix. Laparoscopy showed multiple peritoneal dissemination. We performed intraperitoneal paclitaxel(PTX)administration at 70 mg/m(2) week without any resection of the tumor. Ascites were reduced immediately, but drug-induced interstitial pneumonia occurred due to PTX. After steroid therapy, we switched to systemic S-1 therapy. For about one year, her tumor was controlled but became worse thirteen months after diagnosis and died. It is thought that intraabdominal paclitaxel administration and systemic S-1 therapy can be one of appropriate forms of chemotherapy for inoperable peritoneal carcinomatosis from goblet cell carcinoid of appendix.
authors.affiliation: Division of Internal Medicine, Health Insurance Naruto Hospital, Japan.
authors.forename: Shingen
authors.initials: S
authors.lastname: Nakamura
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kimura
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kashima
authors.forename: Kana
authors.initials: K
authors.lastname: Shichijo
authors.forename: Sumiko
authors.initials: S
authors.lastname: Yoshida
authors.forename: Eiji
authors.initials: E
authors.lastname: Harada
authors.forename: Takaya
authors.initials: T
authors.lastname: Matsushita
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Oshima
authors.forename: Yasutami
authors.initials: Y
authors.lastname: Tamaki
authors.forename: Noriaki
authors.initials: N
authors.lastname: Horiuchi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Takeichi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Masuda
authors.forename: Naohito
authors.initials: N
authors.lastname: Iwasaka
authors.forename: Sadao
authors.initials: S
authors.lastname: Shinomiya
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002276:Carcinoid Tumor / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D003110:Colonic Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel