title: Cancer gene silencing without DNA hypermethylation.
abstract: Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms.
authors.affiliation: Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore. yuq@gis.a-star.edu.sg
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yu
mesh_terms: D000818:Animals; D019175:DNA Methylation; D020868:Gene Silencing; D006657:Histones / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics*
chemical_list: D006657:Histones