[Association between SNAP-25 gene polymorphism and attention deficit hyperactivity disorder].
OBJECTIVE
To analyse the association between polymorphism in human synaptosomal-associated protein of 25 000 (SNAP-25) gene and attention deficit hyperactivity disorder (ADHD) in Han Chinese children.


METHODS
The study samples were comprised of 100 integrated ADHD trios (included proband and biological parents) and 97 unrelated controls. Association of polymorphism with ADHD and its subtype was examined by: (1) comparing cases and controls; (2) using family-based association study in transmission disequilibrium test (TDT).


RESULTS
Case-control analysis of short tandem repeat (STR) showed that there was no significant difference between the two groups in allele gene frequency and genotype frequency (P > 0.05); TDT analysis of the rs363006 SNP and the rs362549 SNP revealed no association between SNAP-25 polymorphisms and ADHD (P > 0.05). But after a stratification by ADHD subtype, the rs362549 SNP A allele showed a tendency to preferentially transmitted to ADHD-I subtype (chi(2) = 8.00, P < 0.01); and the rs362549 SNP G allele had a tendency to preferentially transmitted to ADHD-C subtype (chi(2) = 4.122, P < 0.05).


CONCLUSIONS
No association was found between SNAP-25 polymorphisms and ADHD. There was a possible association between rs362549 SNP polymorphism and ADHD subtypes, but the findings require replication before drawing a definitive conclusion.
Zhang
Hong-yu
HY
Department of Pediatrics, the First Affiliated Hospital, SUN Yat-sen University, Guangzhou, China.
Zhu
Yan-bo
YB
Chang
Hong
H
Chen
Jia-chang
JC
D000293:Adolescent; D000483:Alleles; D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D020641:Polymorphism, Single Nucleotide; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics*
C494208:SNAP25 protein, human; D050825:Synaptosomal-Associated Protein 25