title: Total synthesis without protecting groups: pyrrolidines and cyclic carbamates.
abstract: A protecting group free synthesis of 2,3-cis substituted hydroxypyrrolidines is reported. Two novel reaction methodologies allow for the stereoselective formation of cyclic carbamates from olefinic amines, and the formation of primary amines via a Vasella/reductive amination reaction, both performed in aqueous media.
authors.affiliation: Malaghan Institute of Medical Research, PO Box 7060, Wellington, New Zealand.
authors.forename: Emma M
authors.initials: EM
authors.lastname: Dangerfield
authors.forename: Mattie S M
authors.initials: MS
authors.lastname: Timmer
authors.forename: Bridget L
authors.initials: BL
authors.lastname: Stocker
mesh_terms: D000586:Amination; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002219:Carbamates; D011759:Pyrrolidines