[Effect of Filipendula ulmaria extract on immune system of CBA/CaLac and C57Bl/6 mice].
Extract of Filipendula ulmaria (L.) Maxim administered intragastrically in doses 10, 50, 150 and 500 mg/kg stimulated both inductive and productive phases of the humoral immunity response in CBA/CaLac and C57BL/6 mice. The extract also exhibited pronounced antiinflammatory effect, which was manifested by a decrease in the synthesis of interleukin-2 by splenocytes and by suppression of proinflammatory cytokines production in delayed-type hypersensitivity reaction. At the same time, Filipendula ulmaria extract did not influence the functional activity of peritoneal macrophages.
Churin
A A
AA
Masnaia
N V
NV
Sherstoboev
E Iu
EIu
Shilova
I V
IV
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D031984:Filipendula / Q000737:chemistry; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D000893:Anti-Inflammatory Agents; D007376:Interleukin-2; D010936:Plant Extracts