Dynamics of specific vesicle-substrate adhesion: from local events to global dynamics.
We present a synergistic combination of simulations and experimental data on the dynamics of membrane adhesion. We show that a change in either the density or the strength of the bonds results in very different dynamics. Such behavior is explained by introducing an effective binding affinity that emerges as a result of the competition between the strength of the chemical bonds and the environment defined by the fluctuating membrane.
Reister-Gottfried
Ellen
E
II. Institut für Theoretische Physik, Universität Stuttgart, D-70550 Stuttgart, Germany.
Sengupta
Kheya
K
Lorz
Barbara
B
Sackmann
Erich
E
Seifert
Udo
U
Smith
Ana-Suncana
AS
D002448:Cell Adhesion / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological