Gender risk of nonfatal stroke in type 2 diabetic patients differs depending on the type of treatment.
BACKGROUND
The gender differences in stroke risk among diabetic patients with different treatments have not been studied previously. We aim to determine if there is a gender difference in nonfatal stroke risk in diabetic patients receiving different types of glucose-lowering treatments.


METHODS
In December 2005, data of type 2 diabetic patients were extracted from a nationwide population-based diabetes registry covering 11 Ukrainian regions. Male/female odds ratios (OR) for nonfatal stroke were calculated in three treatment groups: diet only 7,273/15,901, oral glucose-lowering drugs 15,109/33,913, and insulin 5,529/12,462 male/female. Male/female ORs of stroke were estimated using a logistic regression model.


RESULTS
The age-adjusted ORs of stroke were higher among diabetic men compared with diabetic women with oral glucose-lowering drug treatment (OR 1.37, 95% CI 1.22-1.54) and diet treatment only (OR 1.53, 95% CI 1.35-1.73). No differences were found among patients who used insulin (OR 0.97, 95% CI 0.84-1.11). Further adjustment for duration of type 2 diabetes, body mass index (BMI), systolic blood pressure, total cholesterol, and smoking affected the results only slightly.


CONCLUSIONS
The gender risks of nonfatal stroke in patients with type 2 diabetes appear to differ considerably depending on treatment types.
Khalangot
Mykola
M
Institute of Endocrinology and Metabolism, Kiev, Ukraine. nikhalangot@ukr.net
Hu
Gang
G
Tronko
Mykola
M
Kravchenko
Victor
V
Guryanov
Vitaliy
V
D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy*; D003927:Diet, Diabetic / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000145:classification / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D016015:Logistic Models; D008297:Male; D054526:Men's Health; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology; D013997:Time Factors; D014455:Ukraine / Q000453:epidemiology; D016387:Women's Health
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin