title: [Shengjing granule: an effective Chinese medicine for spermatogenic disturbance in mice].
abstract: OBJECTIVE
  To observe the effect of the Chinese medicine Shengjing Granule on spermatogenic disturbance in mice.
  
  
  METHODS
  Forty-six male Kunming mice were randomly divided into a normal (n = 10), a model (n = 12), a control (n = 12) and a Shengjing group (n = 12), and models of spermatogenic disturbance were established by intraperitoneal injection of cyclophosphamide in the latter three. Then the first two groups received intragastric administration of physiological saline and the second two that of clomiphene (21.6 mg/kg x d) and Shengjing Granule (16 g/kg x d), respectively, all for 15 days. On the following day, the testis weight was measured, the levels of the follicle stimulating hormone (FSH), the luteinizing hormone (LH) and testosterone (T) determined by radioimmunoassay. Histological observations were made of the testis tissues under the microscope.
  
  
  RESULTS
  The testis index and T level were (3.958 +/- 0.342) g/kg and (7.046 +/- 0.291) nmo/L, obviously increased, while the levels of FSH and LH were (2.947 +/- 0.587) mIU/ml and (3.254 +/- 0.492) mIU/ml, significantly decreased, in the Shengjing group, as compared with (3.525 +/- 0.462) g/kg, (6.231 +/- 0.317) nmol/L, (5.428 +/- 0.719) mIU/ml and (5.155 +/- 0.460) mIU/ml in the model group (P < 0.05). The number of spermatogenic cells on the seminiferous tubules and that of sperm in the lumina of the tubules were markedly increased in the Shenginjg group, compared with the models. CoCONCLUSIONShenginjg Granule is effective for spermatogenic disturbance in mice.
authors.affiliation: Department of Urology, The First Hospital Affiliated to Zhengzhou University/Open Laboratory for Clinical Medicine, Key Discipline of Henan Higher Education, Zhengzhou, Henan 450052, China. huzi918@hotmail.com
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Wei-Xing
authors.initials: WX
authors.lastname: Zhang
authors.forename: Yu-Feng
authors.initials: YF
authors.lastname: Wu
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Shi
authors.forename: Yue-Xi
authors.initials: YX
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008517:Phytotherapy; D013091:Spermatogenesis
chemical_list: D004365:Drugs, Chinese Herbal