[A case of peritonitis carcinomatosa from goblet cell carcinoid of the appendix treated by intraperitoneal paclitaxel and systemic S-1 chemotherapy].
Goblet cell carcinoid of the appendix is a rare neoplasm and clinically tends to take a malignant course. Most cases are young and early stage, and the surgical strategy is available. But appropriate chemotherapy for inoperable cases with peritoneal dissemination is not established. A 77-year-old woman with a past history of appendectomy was admitted to our hospital complaining of abdominal fullness. Abdominal computed tomography showed massive ascites and slight contrast enhancement of appendix. A tumor was found by colonoscopic examination at the orifice of vermiform and was diagnosed pathologically as goblet cell carcinoid of the appendix. Laparoscopy showed multiple peritoneal dissemination. We performed intraperitoneal paclitaxel(PTX)administration at 70 mg/m(2) week without any resection of the tumor. Ascites were reduced immediately, but drug-induced interstitial pneumonia occurred due to PTX. After steroid therapy, we switched to systemic S-1 therapy. For about one year, her tumor was controlled but became worse thirteen months after diagnosis and died. It is thought that intraabdominal paclitaxel administration and systemic S-1 therapy can be one of appropriate forms of chemotherapy for inoperable peritoneal carcinomatosis from goblet cell carcinoid of appendix.
Nakamura
Shingen
S
Division of Internal Medicine, Health Insurance Naruto Hospital, Japan.
Kimura
Shigeaki
S
Kashima
Masahiro
M
Shichijo
Kana
K
Yoshida
Sumiko
S
Harada
Eiji
E
Matsushita
Takaya
T
Oshima
Yasushi
Y
Tamaki
Yasutami
Y
Horiuchi
Noriaki
N
Takeichi
Toshiaki
T
Fujimoto
Hiroshi
H
Masuda
Kazuhiko
K
Iwasaka
Naohito
N
Shinomiya
Sadao
S
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D002276:Carcinoid Tumor / Q000150:complications / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D003110:Colonic Neoplasms / Q000150:complications / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D010094:Oxonic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D017239:Paclitaxel / Q000008:administration & dosage / Q000627:therapeutic use*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D017211:Treatment Failure
D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D017239:Paclitaxel