Diet supplement CoQ10 delays brain atrophy in aged transgenic mice with mutations in the amyloid precursor protein: an in vivo volume MRI study.
We tested the hypotheses that supplemental intake of the diet supplement Coenzyme Q10 (CoQ10) could delay brain atrophy in double transgenic amyloid precursor protein (APP) / presenilin 1 (PS1), single transgenic APP and PS1 as well as wild type mice by volume MR image in vivo. One hundred and twelve mice (28 APP/PS1, 28 APP, 28 PS1 and 28 wild types) were studied. Half of each genotype group (n = 14 per group) was treated with CoQ10 2400 mg/kg/day, and the other half with placebo for 60 days. Magnetic resonance (MR) images were used to obtain the volumes of the hemispheres and hippocampi. APP / PS1, APP, PS1 and wild type mice treated with CoQ10 exhibited significantly less atrophy in hemisphere and hippocampus than those receiving placebo. The neuro-protective effect of the CoQ10 on hemispheric volume, and hippocampal volume was related to genotype; greater in APP/PS1 than APP and PS1 mice and less in wild type mice. Our result indicated that CoQ10 may have therapeutic potential in the prevention and treatment of MCI and AD.
Li
Geng
G
Hong Kong Applied Science and Technology Research Institute Company Limited, Hong Kong, HKSAR, China. gli@astri.org
Jack
Clifford R
CR
Yang
Xi-Fei
XF
Yang
Edward S
ES
D000375:Aging / Q000502:physiology*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001284:Atrophy / Q000517:prevention & control; D001921:Brain / Q000473:pathology*; D054022:Cerebrum / Q000033:anatomy & histology / Q000187:drug effects; D003072:Cognition Disorders / Q000517:prevention & control; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006624:Hippocampus / Q000033:anatomy & histology / Q000187:drug effects; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D053764:Presenilin-1 / Q000235:genetics; D000685:Serum Amyloid A Protein / Q000235:genetics*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000975:Antioxidants; D016166:Free Radical Scavengers; D053764:Presenilin-1; D000685:Serum Amyloid A Protein; D014451:Ubiquinone; C024989:coenzyme Q10