The current understanding of Ded1p/DDX3 homologs from yeast to human.
DExD/H-box RNA helicases are involved in almost all steps of the eukaryotic mRNA biogenesis. The DEAD-box protein Ded1p/DDX3 is conserved from yeast to human. Various lines of genetic and biochemical evidence have indicated a role of the yeast Ded1p in translation and, most likely, in precursor mRNA splicing as well. In contrast, although recent studies have begun to reveal the function of the mammalian DDX3 in translation control, its exact role remains vague and even controversial. Here, we review these findings and particularly discuss the functional aspects of Ded1p/DDX3 in translation control.
Tarn
Woan-Yuh
WY
Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei, Taiwan. wtarn@ibms.sinica.edu.tw
Chang
Tien-Hsien
TH
D017398:Alternative Splicing; D000818:Animals; D001671:Biochemistry / Q000379:methods; D002467:Cell Nucleus / Q000378:metabolism; D053487:DEAD-box RNA Helicases / Q000378:metabolism*; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008954:Models, Biological; D008957:Models, Genetic; D014176:Protein Biosynthesis; D020365:RNA Helicases / Q000737:chemistry* / Q000378:metabolism; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; C492152:DED1 protein, S cerevisiae; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases