title: Synthesis and evaluation of novel chloropyridazine derivatives as potent human rhinovirus (HRV) capsid-binding inhibitors.
abstract: Human rhinovirus (HRV) is the most important etiologic agent causing common colds. No effective anti-HRV agents are currently available. In this paper we describe the synthesis and the evaluation of novel chloropyridazine derivatives (compounds 5a-g) as potent human rhinovirus (HRV) capsid-binding inhibitors. Results showed that compound 5e and 5f exhibited effective anti-HRV activity against HRV-2 and HRV-14. In addition, compound 5e and 5f showed lower cytotoxicity than Pirodavir.
authors.affiliation: Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Beijing 100850, China.
authors.forename: Shi-Yong
authors.initials: SY
authors.lastname: Fan
authors.forename: Zhi-Bing
authors.initials: ZB
authors.lastname: Zheng
authors.forename: Chun-Lai
authors.initials: CL
authors.lastname: Mi
authors.forename: Xin-Bo
authors.initials: XB
authors.lastname: Zhou
authors.forename: Hui
authors.initials: H
authors.lastname: Yan
authors.forename: Ze-Hui
authors.initials: ZH
authors.lastname: Gong
authors.forename: Song
authors.initials: S
authors.lastname: Li
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D036022:Capsid Proteins / Q000037:antagonists & inhibitors*; D003139:Common Cold / Q000188:drug therapy; D006801:Humans; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D012229:Rhinovirus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D036022:Capsid Proteins; D011724:Pyridazines; C062482:pyridazine