Gastric schwannoma.
Schwannomas, also known as neurinomas or neurilemmomas, are generally benign, slow-growing neoplasms originating in any nerve that has a Schwann cell sheath. These neoplasms are rare among the spindle cell mesenchymal tumors of the gastrointestinal tract, but develop most commonly in the stomach representing 0.2% of all gastric tumors. We present the case of a 57-year-old female patient with a large schwannoma in the stomach that was palpable in the abdomen. She underwent subtotal gastrectomy under suspicion of gastrointestinal stromal tumor (GIST), but post-operative histopathological and immunohistochemical findings showed a fascicular arrangement of spindle cell with pallisading nuclei, and positive for S-100 protein with negative smooth muscle actin (SMA). These results confirmed schwannoma as the diagnosis.
Yoon
Ho Young
HY
Department of surgery, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.
Kim
Choong Bai
CB
Lee
Yoon Hee
YH
Kim
Ho Guen
HG
D003937:Diagnosis, Differential; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009442:Neurilemmoma / Q000175:diagnosis* / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D009418:S100 Proteins