title: [Endoscopic mucosal resection of Abrikosoff's tumor of the esophagus].
abstract: Abrikosoff's tumor (AT), or granular cell tumor (GCT), is relatively rare in the gastrointestinal tract, where the most common site is the esophagus. This tumor is usually found incidentally when an upper gastrointestinal endoscopy is carried out for another reason. Endoscopically, GCT appears as a small, yellow and submucosal lesion covered by normal mucosa. Endoscopic ultrasonography shows a homogeneous hypoechoic lesion with well defined margins. The definitive diagnosis is histological. The origin of GCT is neurogenic and the tumor is composed of eosinophilic granular cytoplasm and PAS-positive cells, which show the S-100 protein on immunohistochemistry. Although GCT is usually clinically and histologically benign, some malignant cases have been reported. Consensus is lacking on the treatment and follow-up of this tumor. Currently, endoscopic mucosal resection is a safe and effective technique to treat submucosal esophageal lesions, allowing subsequent histologic analysis. We present three patients with esophageal CGT, who were definitively treated with endoscopic mucosal resection.
authors.affiliation: Servicio de Gastroenterología, Hospital Universitario Ramón y Cajal, Madrid, España.
authors.forename: Elena
authors.initials: E
authors.lastname: Garrido
authors.forename: Elena
authors.initials: E
authors.lastname: Marín
authors.forename: Carmen
authors.initials: C
authors.lastname: González
authors.forename: Diego
authors.initials: D
authors.lastname: Juzgado
authors.forename: Daniel
authors.initials: D
authors.lastname: Boixeda
authors.forename: Enrique
authors.initials: E
authors.lastname: Vázquez-Sequeiros
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D004938:Esophageal Neoplasms / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D004945:Esophagoscopy; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009418:S100 Proteins