[Improving myocardial mechanics parameters of severe burn rabbits with oral fluid resuscitation].
OBJECTIVE
To investigate the protective effect of oral fluid resuscitation on cardiac function in severe burn rabbits.


METHODS
One hundred and fifty rabbits were randomly divided into normal control group (NC group, n = 6, without treatment), burn group (B group, n = 42, without fluid therapy), immediate oral fluid resuscitation group (C group, n = 42), delayed oral fluid resuscitation group (D group, n = 30) and delayed and rapid oral fluid resuscitation group (E group, n = 30). The rabbits in B, C, D, E groups were subjected to 40% TBSA full-thickness burn, then were treated with fluid therapy immediately after burn (C group), at 6 hour after burn (D, E groups). The myocardial mechanics parameters including mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), left ventricular end diastolic pressure (LVEDP), LV +/- dp/dt max were observed at 2, 6, 8, 12, 24, 36 and 48 post burn hour (PBH). Urine output was also examined.


RESULTS
The level of LVSP, LV +/- dp/dt max in B roup were significantly lower than those in NC group. The level of LVSP, LV +/- dp/dt max in the C and E group were singnificantly increased during 24 hour after burn. The level of LV + dp/dt max and LV-dp/dt max in C group peaked at 8 PBH (892 +/- 116 kPa/s) and at 6PBH (724 +/- 149 kPa/s) respectively. The levels of LV +/- dp/dt max, LVSP in D group at each time point were similar to B group (P > 0.05). Both the levels of LV +/- dp/dt max in E group peaked at 8 PBH. The level of LVEDP was no obvious difference between B and other groups at each time point (P > 0.05). The changes of MAP and urine output on 24 PBH in each group were similar to above indices.


CONCLUSIONS
Effective oral fluid therapy in severe burn rabbits during 24 hours after burn can ameliorate myocardial mechanics parameters. The amount of fluid resuscitation can be estimated according to relevant formula for delayed fluid resuscitation in burn rabbits.
Ruan
Jing
J
Institute of Burn Research, Southwest Hospital, State Key Laboratoray of Trauma, Burns and Combined Injury, the Third Military Medical University, Chongqing 400038, PR China.
Zhang
Bing-qian
BQ
Wang
Guang
G
Luo
Zhong-hua
ZH
Zheng
Qing-yi
QY
Zheng
Jian-sheng
JS
Huang
Yue-sheng
YS
Xiao
Rong
R
D000818:Animals; D002056:Burns / Q000503:physiopathology* / Q000628:therapy*; D002302:Cardiac Output; D005440:Fluid Therapy; D006339:Heart Rate; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D016276:Ventricular Function