Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging.
We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (~4 μm) of retinal images, while maintaining the high axial resolution (~6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.
Zawadzki
Robert J
RJ
Department of Ophthalmology and Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, California 95817 rjzawadzki@ucdavis.edu.
Jones
Steven M
SM
Olivier
Scot S
SS
Zhao
Mingtao
M
Bower
Bradley A
BA
Izatt
Joseph A
JA
Choi
Stacey
S
Laut
Sophie
S
Werner
John S
JS