Correlation analysis of HOX, ErbB and IGFBP family gene expression in ovarian cancer.
Utilizing microarray gene expression data in cancer research possesses the ability to identify deregulated cellular pathways involved in malignant development. This study investigated the relationships of three gene families, HOX, ErbB and IGFBP, with regard to the development of ovarian cancer. These families were of interest because of similar chromosomal locations and their deregulated expression in ovarian cancer. Higher level statistics were used to differentially analyze microarray data in 65 ovarian samples to assess correlation and relationships among the gene families of interest. Fifteen genes in the three families were found to be significantly deregulated. Thirty-eight significant correlations were found within and between the genes of interest. Our data indicates that the significantly modeled relationships between HOX, ErbB and IGFBP gene pairs could provide insight into the underlying biological mechanisms in ovarian cancer.
Bahrani-Mostafavi
Zahra
Z
Cannon Research Center, Molecular Biology Core Facility, Carolinas Medical Center, Charlotte, NC 28203, USA. zahra.mostafavi@carolinashealthcare.org
Tickle
Timothy L
TL
Zhang
Jian
J
Bennett
Kristen E
KE
Vachris
Judith C
JC
Spencer
Melanie D
MD
Mostafavi
M Taghi
MT
Tait
David L
DL
D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics*; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D010051:Ovarian Neoplasms / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018398:Homeodomain Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D012334:RNA, Neoplasm; C512478:EGFR protein, human; D066246:ErbB Receptors