Evaluation of a multi-layer microbraided polylactic acid fiber-reinforced conduit for peripheral nerve regeneration.
We evaluated peripheral nerve regeneration using a biodegradable multi-layer microbraided polylactic acid (PLA) fiber-reinforced conduit. Biodegradability of the PLA conduit and its effectiveness as a guidance channel were examined as it was used to repair a 10 mm gap in the rat sciatic nerve. As a result, tube fragmentation was not obvious and successful regeneration through the gap occurred in all the conduits at 8 weeks after operation. These results indicate the superiority of the PLA materials and suggest that the multi-layer microbraided PLA fiber-reinforced conduits provide a promising tool for neuro-regeneration.
Lu
Ming-Chin
MC
School of Post Baccalaureate Chinese Medicine, China Medical University, Taichung, Taiwan. lumc@mail.cmu.edu.tw
Huang
Yen-Ting
YT
Lin
Jia-Horng
JH
Yao
Chun-Hsu
CH
Lou
Ching-Wen
CW
Tsai
Chin-Chuan
CC
Chen
Yueh-Sheng
YS
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry*; D055724:Electrophysiological Phenomena; D005071:Evoked Potentials; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D009416:Nerve Regeneration; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000473:pathology / Q000502:physiology / Q000601:surgery; D013997:Time Factors; D054457:Tissue Scaffolds / Q000737:chemistry*
D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)