title: Parvovirus capsid disorders cholesterol-rich membranes.
abstract: In this study canine parvovirus, CPV, was found to induce disorder in DPPC:cholesterol membranes in acidic conditions. This acidicity-induced fluidizing effect is suggested to originate from the N-terminus of the viral capsid protein VP1. In accordance with the model membrane studies, a fluidizing effect was seen also in the endosomal membranes during CPV infection implying an important functional role of the fluidization in the endocytic entry of the virus.
authors.affiliation: Department of Biological and Environmental Science and Nanoscience Center, P.O. Box 35, FIN-40014 University of Jyväskylä, Finland. kirsi.i.pakkanen@jyu.fi
authors.forename: Kirsi
authors.initials: K
authors.lastname: Pakkanen
authors.forename: Sanna
authors.initials: S
authors.lastname: Kirjavainen
authors.forename: Anna R
authors.initials: AR
authors.lastname: Mäkelä
authors.forename: Nina
authors.initials: N
authors.lastname: Rintanen
authors.forename: Christian
authors.initials: C
authors.lastname: Oker-Blom
authors.forename: Tuula O
authors.initials: TO
authors.lastname: Jalonen
authors.forename: Matti
authors.initials: M
authors.lastname: Vuento
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D002213:Capsid / Q000737:chemistry*; D036022:Capsid Proteins / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008560:Membrane Fluidity; D008567:Membranes, Artificial; D017993:Parvovirus, Canine / Q000737:chemistry*
chemical_list: D036022:Capsid Proteins; D008567:Membranes, Artificial; D015060:1,2-Dipalmitoylphosphatidylcholine; D002784:Cholesterol