title: Edible mushroom Agaricus sylvaticus can prevent the onset of atheroma plaques in hipercholesterolemic rabbits.
abstract: Since the involvement of free radicals in the pathophysiology of atherosclerosis was proposed, antioxidant supplementation arose as a potential strategy for the management of this disease. Thus, we decided to investigate the potential benefit of a natural antioxidant--rich edible mushroom (Agaricus sylvaticus) on the prevention of atherosclerosis. New Zealand rabbits underwent atherosclerosis induction by feeding a cholesterol--enriched chow (Group A), while Group B simultaneously received edible mushroom A. sylvaticus water solution. Control group received standard rabbit chow only (Group C). At the end of 10 week treatment period serum samples were drawn for lipid profile, uric acid, thiobarbituric acid reactive substances (TBARS), and total antioxidant status (TAS). The area of aorta arteries taken by atheroma plaques was evaluated. Groups A and B presented higher cholesterol levels (p< 0.01) and reduced TAS (p<0.01), when compared to the Group C. However, TBARS and uric acid levels for Group B animals' were reduced, in comparison to Group A (p<0.05), and equals to group C. Moreover, animals from group A developed extensive atherosclerotic areas (47.0+/-14.0%), and that was prevented by the supplementation of A. sylvaticus (6.6+/-2.9%, p<0.01). Data suggested that A. sylvaticus can prevent the development of atherosclerosis in spite of hipercholesterolemia.
authors.affiliation: Federal University of Para Free, Radical Biochemistry Research Lab, Tropical Medicine Institute Umarizal, Belém, PA, Brazil. percario@ufpa.br
authors.forename: S
authors.initials: S
authors.lastname: Percario
authors.forename: V F
authors.initials: VF
authors.lastname: Odorizzi
authors.forename: D R S
authors.initials: DR
authors.lastname: Souza
authors.forename: M A S
authors.initials: MA
authors.lastname: Pinhel
authors.forename: J L
authors.initials: JL
authors.lastname: Gennari
authors.forename: M S
authors.initials: MS
authors.lastname: Gennari
authors.forename: M F
authors.initials: MF
authors.lastname: Godoy
mesh_terms: D000364:Agaricus / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000032:analysis; D001011:Aorta / Q000473:pathology; D050197:Atherosclerosis / Q000139:chemically induced / Q000517:prevention & control*; D002791:Cholesterol, Dietary; D006937:Hypercholesterolemia / Q000139:chemically induced / Q000150:complications*; D008055:Lipids / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D011817:Rabbits; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014527:Uric Acid / Q000097:blood
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014527:Uric Acid