title: A short history of cGMP, guanylyl cyclases, and cGMP-dependent protein kinases.
abstract: Here, we review the early studies on cGMP, guanylyl cyclases, and cGMP-dependent protein kinases to facilitate understanding of development of this exciting but complex field of research encompassing pharmacology, biochemistry, physiology, and molecular biology of these important regulatory molecules.
authors.affiliation: The University of Texas Health Science Center at Houston, Institute of Molecular Medicine, 1825 Pressler St., Houston, TX 77030, USA.
authors.forename: Alexander Y
authors.initials: AY
authors.lastname: Kots
authors.forename: Emil
authors.initials: E
authors.lastname: Martin
authors.forename: Iraida G
authors.initials: IG
authors.lastname: Sharina
authors.forename: Ferid
authors.initials: F
authors.lastname: Murad
mesh_terms: D000818:Animals; D006152:Cyclic GMP / Q000266:history / Q000378:metabolism*; D017869:Cyclic GMP-Dependent Protein Kinases / Q000266:history / Q000378:metabolism*; D006162:Guanylate Cyclase / Q000266:history / Q000378:metabolism*; D049673:History, 20th Century; D006801:Humans; D011487:Protein Conformation; D020033:Protein Isoforms; D015398:Signal Transduction
chemical_list: D020033:Protein Isoforms; D017869:Cyclic GMP-Dependent Protein Kinases; D006162:Guanylate Cyclase; D006152:Cyclic GMP