title: Synthesis and evaluation of guanidinyl pyrrolidines as bifunctional catalysts for enantioselective conjugate additions to cyclic enones.
abstract: Guanidinyl pyrrolidines derived from 'S'-proline are effective catalysts for the enantioselective conjugate addition of malonate, nitroalkane and other carbon and heteroatom nucleophiles to cyclohexenone and cyclopentenone in the absence of basic additives. The stereoselectivity is strongly dependent on catalyst loading as well as reaction concentration.
authors.affiliation: Department of Chemistry, Memorial University, St. John's, Newfoundland, Canada A1B3X7. spansare@mun.ca
authors.forename: Sunil V
authors.initials: SV
authors.lastname: Pansare
authors.forename: Rajinikanth
authors.initials: R
authors.lastname: Lingampally