Regulation of transcription factor activity by SUMO modification.
Post-translational modification by SUMO is an important mechanism to regulate transcription. Sumoyla-tion has diverse effects on substrate activity, but in most cases reported to date sumoylation of transcription factors correlated with transcriptional repression. Here we describe general strategies to address how post-translational modification by SUMO regulates the activity of a DNA-binding transcription factor.
Ouyang
Jian
J
Department of Anatomy and Cellular Biology, Tufts University School of Medicine, Boston, MA, USA.
Valin
Alvaro
A
Gill
Grace
G
D000818:Animals; D005786:Gene Expression Regulation; D017930:Genes, Reporter / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D050505:Mutant Proteins / Q000378:metabolism / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology; D011993:Recombinant Fusion Proteins / Q000378:metabolism / Q000502:physiology; D025842:SUMO-1 Protein / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*
D050505:Mutant Proteins; D011993:Recombinant Fusion Proteins; D025842:SUMO-1 Protein; D014157:Transcription Factors