Synthesis of unsymmetrical ketones via simple C-H activation of aldehydes and concomitant hydroacylation of vinyl sulfonates.
A new and simple protocol for the direct functionalisation of aldehydes with concomitant conversion into ketones via C-C bond formation has been developed. The reaction effectively enables the direct C-H activation of an aldehyde by mixing of an aldehyde and a vinyl sulfonate under aerobic conditions or using hydrogen peroxide as a sub-stoichiometric reagent.
Fitzmaurice
Richard J
RJ
Department of Chemistry, University College London, London, UK.
Ahern
Jenna M
JM
Caddick
Stephen
S
D000215:Acylation; D000447:Aldehydes / Q000737:chemistry*; D000476:Alkanesulfonates / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry; D007659:Ketones / Q000138:chemical synthesis*
D000447:Aldehydes; D000476:Alkanesulfonates; D007659:Ketones; D002244:Carbon; D006859:Hydrogen; D006861:Hydrogen Peroxide