title: [Cerebrospinal fluid markers of prion diseases].
abstract: There are no non-invasive tests allowing for definite premortem diagnosis of Creutzfeldt-Jakob disease (CJD). The paper presents the current knowledge about laboratory tests supporting CJD diagnosis. 14-3-3 protein in the cerebrospinal fluid is the only biochemical marker included in the diagnostic criteria for CJD approved by WHO. However, the test for 14-3-3 protein is useful only when considered in an appropriate clinical context, together with other diagnostic criteria. In the paper we also present current research in the use of other proteins detected in the cerebrospinal fluid (tau, S100b, neuron-specific enolase, transthyretin, and beta-amyloid1-42 as potential diagnostic markers. We discuss advantages and drawbacks of these markers.
authors.affiliation: Zakład Patologii Molekularnej i Neuropatologii, Uniwersytet Medyczny w Łodzi, Łódź. golanska@wp.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Golańska
authors.forename: Sylwia
authors.initials: S
authors.lastname: Gresner
authors.forename: Monika
authors.initials: M
authors.lastname: Sieruta
authors.forename: Paweł
authors.initials: P
authors.lastname: Liberski
mesh_terms: D048948:14-3-3 Proteins / Q000134:cerebrospinal fluid*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D006801:Humans; D011328:Prions / Q000134:cerebrospinal fluid
chemical_list: D048948:14-3-3 Proteins; D015415:Biomarkers; D011328:Prions