title: Investigation of detection limits for diffuse optical tomography systems: II. Analysis of slab and cup geometry for breast imaging.
abstract: Using a statistical (chi-square) test on simulated data and a realistic noise model derived from the system's hardware we study the performance of diffuse optical tomography systems for fluorescence imaging. We compare the predicted smallest size of detectable lesions at various positions in slab and cup geometry and model how detection sensitivity depends on breast compression and lesion fluorescence contrast. Our investigation shows that lesion detection is limited by relative noise in slab geometry and by absolute noise in cup geometry.
authors.affiliation: Philips Research Europe-Hamburg, Röntgenstr. 24, 22335 Hamburg, Germany.
authors.forename: Ronny
authors.initials: R
authors.lastname: Ziegler
authors.forename: Bernhard
authors.initials: B
authors.lastname: Brendel
authors.forename: Herbert
authors.initials: H
authors.lastname: Rinneberg
authors.forename: Tim
authors.initials: T
authors.lastname: Nielsen
mesh_terms: D055592:Biophysical Phenomena; D001943:Breast Neoplasms / Q000175:diagnosis*; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D008962:Models, Theoretical; D019047:Phantoms, Imaging / Q000706:statistics & numerical data; D017785:Photons; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods* / Q000706:statistics & numerical data
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes