title: The application of Prague C and M criteria in the diagnosis of Barrett's esophagus in an ethnic Chinese population.
abstract: OBJECTIVE
  To investigate the prevalence of endoscopically suspected esophageal metaplasia (ESEM) in an ethnic Chinese population by endoscopic and pathologic evaluation and to assess the utility of Prague C and M criteria.
  
  
  METHODS
  Consecutive patients who received esophagogastroduodenoscopy either as a part of therapy for various upper abdominal symptoms or as an annual health check-up were evaluated for the existence of ESEM and Barrett's esophagus (BE). Biopsy with standardized random four pieces every 2 cm from the four quarters of esophagus with ESEM lesion was performed. BE was defined by histological verification of specialized intestinal metaplasia and gastric metaplasia and was categorized according to the Prague C and M criteria.
  
  
  RESULTS
  A total of 5,179 subjects were screened from Jan. 2007 to Dec. 2007. This study enrolled 4,797, including 3,386 for referral endoscopy and 1,411 for screening endoscopy. Prevalence of BE among the referral endoscopy, screening endoscopy, and overall was 1.06%, 0.35%, and 0.85%, respectively. A total of 41 subjects with BE were detected among 93 ESEM subjects. Short segment BE (75.6%, n=31) was more prevalent than long segment BE (24.4%, n=10). The proportions of BE from subjects with ESEM by Prague C and M criteria were C< or =1M1 38.9% (19/50), C< or =1M2 40% (12/30), and CxM> or =3 76.9% (10/13).
  
  
  CONCLUSIONS
  On the basis of the standardized protocol with random four-quadrate endoscopic biopsy, we have demonstrated the utility of Prague C and M criteria to characterize the BE in an ethnic Chinese population.
authors.affiliation: Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
authors.forename: Chi-Yang
authors.initials: CY
authors.lastname: Chang
authors.forename: Yi-Chia
authors.initials: YC
authors.lastname: Lee
authors.forename: Ching-Tai
authors.initials: CT
authors.lastname: Lee
authors.forename: Chia-Hung
authors.initials: CH
authors.lastname: Tu
authors.forename: Jau-Chung
authors.initials: JC
authors.lastname: Hwang
authors.forename: Hung
authors.initials: H
authors.lastname: Chiang
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Tai
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Chiang
authors.forename: Ming-Shiang
authors.initials: MS
authors.lastname: Wu
authors.forename: Jaw-Town
authors.initials: JT
authors.lastname: Lin
mesh_terms: D044466:Asian People; D001471:Barrett Esophagus / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D016145:Endoscopy, Digestive System; D004941:Esophagitis / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013624:Taiwan / Q000453:epidemiology