Experimental model of acute ischemia of the retina in rats.
We studied the development of retinal ischemia in rat eye after laser coagulation of blood vessels. Typical signs of ischemia manifested in the retina after 24 h: development of stable retinal edema, decrease in the b/a index (ratio of the electroretinogram b and a-wave amplitudes) to 1-2 units, pronounced disorders in the retinal microcirculation system, leading to ischemia of the inner layers of the retina. The proposed model is convenient for studies of the development of acute retinal ischemia, is easily realized, and reproduces some acute ischemic diseases of the retina.
Kalamkarov
G R
GR
N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Russia. kalam2@rambler.ru
Tsapenko
I V
IV
Zueva
M V
MV
Ivanov
A N
AN
Konstantinova
T S
TS
Bugrova
A E
AE
Rezvykh
S V
SV
Fedorov
A A
AA
Shevchenko
T F
TF
D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004596:Electroretinography; D007511:Ischemia / Q000150:complications*; D017075:Laser Coagulation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012160:Retina; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology*