Synthesis of Substituted 2-phenylhistamines via a Microwave Promoted Suzuki Coupling.
Substitutions on the 2-position of the imidizole ring of histamine have proven useful in a number of biochemical settings. Current art for the synthesis of these constructs relies upon a cumbersome and low-yielding condensation reaction. Here-in we report a new procedure for the synthesis of a series of substituted 2-phenylhistamines utilizing a microwave-promoted Suzuki coupling.
Skoumbourdis
Amanda P
AP
NIH Chemical Genomics Center, National Human Genome Research Institute, NIH 9800 Medical Center Drive, MSC 3370 Bethesda, MD 20892-3370 USA.
Moore
Susanna
S
Landsman
Marc
M
Thomas
Craig J
CJ