title: Serum paraoxonase and arylesterase activities in patients with epithelial ovarian cancer.
abstract: OBJECTIVE
  The HDL-associated paraoxonase and arylesterase activities play a role in decreasing oxidative stress, which is known to contribute to cancer development. The aim of this study was to evaluate serum paraoxonase and arylesterase activities and lipid hydroperoxide (LOOH) levels in patients with newly-diagnosed epithelial ovarian cancer.
  
  
  METHODS
  Serum paraoxonase and arylesterase activities, total free sulfhydryl (-SH) levels and LOOH levels were measured in patients with epithelial ovarian cancer (n=24) and controls (n=29).
  
  
  RESULTS
  Serum paraoxonase activity and arylesterase activity, as well as -SH levels were significantly lower (p=0.003, p<0.001 and p<0.001, respectively) in patients with epithelial ovarian cancer compared to controls, while LOOH levels were significantly higher (p<0.001). A significant inverse correlation was found between the stage, grade and CA-125 level of ovarian cancer and paraoxonase activity (rho=-0.630, p=0.001 and rho=-0.601, p=0.002 and rho=-0.436, p=0.033, respectively), arylesterase activity (rho=-0.601, p=0.002 and rho=-0.713, p<0.001 and rho=-0.580, p=0.003, respectively), and -SH levels (rho=-0.642, p=0.001 and rho=-0.637, p=0.001 and rho=-0.530, p=0.008, respectively). In contrast, there was a positive correlation between LOOH and the stage, grade and CA-125 level of ovarian cancer (rho=0.565, p=0.004 and rho=0.479, p=0.018 and rho=0.642, p=0.001).
  
  
  CONCLUSIONS
  Our results suggest that diminished paraoxonase and arylesterase activity, -SH levels and increased LOOH levels are associated with particular stage, grade and CA-125 level of ovarian cancer.
authors.affiliation: Harran University, Faculty of Medicine, Department of Obstetrics and Gynecology, Sanliurfa, 63100, Turkey. hakancamuzcuoglu@gmail.com
authors.forename: Hakan
authors.initials: H
authors.lastname: Camuzcuoglu
authors.forename: Dagistan Tolga
authors.initials: DT
authors.lastname: Arioz
authors.forename: Harun
authors.initials: H
authors.lastname: Toy
authors.forename: Sefa
authors.initials: S
authors.lastname: Kurt
authors.forename: Hakim
authors.initials: H
authors.lastname: Celik
authors.forename: Ozcan
authors.initials: O
authors.lastname: Erel
mesh_terms: D043303:Aryldialkylphosphatase / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D014408:Biomarkers, Tumor; D008076:Cholesterol, HDL; D008054:Lipid Peroxides; D013438:Sulfhydryl Compounds; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase