Counterattack mode differential acetylative deprotection of phenylmethyl ethers: applications to solid phase organic reactions.
A counterattack protocol for differential acetylative cleavage of phenylmethyl ether has been developed. The phenylmethyl moiety is liberated as benzyl bromide that is isolated and reused providing advantages in terms of waste minimization/utilization and atom economy. The applicability of this methodology has been extended for solid phase organic reactions with the feasibility of reuse of the solid support.
Chakraborti
Asit K
AK
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Sector 67, S. A. S. Nagar 160 062, Punjab, India. akchakraborti@niper.ac.in
Chankeshwara
Sunay V
SV
D000107:Acetylation; D002625:Chemistry, Organic / Q000379:methods; D010647:Phenyl Ethers / Q000138:chemical synthesis / Q000737:chemistry*
D010647:Phenyl Ethers