title: Chronic kidney disease with three cases of oxalate-like nephrosis in Ragdoll cats.
abstract: Two unrelated Ragdoll cat mothers in Norway were found dead from renal disease. The histopathology was consistent with oxalate nephrosis with chronic or acute-on-chronic underlying kidney disease. Both cats had offspring and relatives with signs of urinary tract disease, including a kitten dead with urethral gravel. Eleven living Ragdoll cats, including nine relatives of the dead cats and the male father of a litter with similarly affected animals, were tested for primary hyperoxaluria (PH) type 1 and 2 by urine oxalate and liver enzyme analysis. Renal ultrasound revealed abnormalities in five living cats. One of these was azotaemic at the time of examination and developed terminal kidney disease 9 months later. A diagnosis of PH was excluded in 11 cats tested. The inheritance and aetiological background of the renal disease present in the breed remains unresolved at this point in time.
authors.affiliation: Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, N-0033 Oslo, Norway. reidun.heiene@veths.no
authors.forename: Reidun
authors.initials: R
authors.lastname: Heiene
authors.forename: Gill
authors.initials: G
authors.lastname: Rumsby
authors.forename: Martine
authors.initials: M
authors.lastname: Ziener
authors.forename: Stein A
authors.initials: SA
authors.lastname: Dahl
authors.forename: Christopher
authors.initials: C
authors.lastname: Tims
authors.forename: Jon
authors.initials: J
authors.lastname: Teige
authors.forename: Nina
authors.initials: N
authors.lastname: Ottesen
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology* / Q000652:urine; D002415:Cats; D005260:Female; D006960:Hyperoxaluria, Primary / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D008297:Male; D009401:Nephrosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D009664:Norway; D010070:Oxalates / Q000652:urine; D014463:Ultrasonography
chemical_list: D010070:Oxalates