Should HLA-B*5701 screening be performed in every ethnic group before starting abacavir?
Human leukocyte antigen allele (HLA)-B*5701 is associated with abacavir hypersensitivity. However, the carriage rate of HLA-B*5701 has rarely been studied in Asians. In 534 Korean patients with human immunodeficiency virus infection, HLA-B*5701 status was determined by polymerase chain reaction with HLA-B*5701-specific primers. No patients had the HLA-B*5701 allele (95% confidence interval, 0%-0.7%). This explains the paucity of immunologically confirmed cases of abacavir hypersensitivity in Koreans.
Park
Wan Beom
WB
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
Choe
Pyoeng Gyun
PG
Song
Kyoung-Ho
KH
Lee
Shinwon
S
Jang
Hee-Chang
HC
Jeon
Jae Hyun
JH
Park
Sang-Won
SW
Park
Myoung Hee
MH
Oh
Myoung-don
MD
Choe
Kang Won
KW
D000328:Adult; D015224:Dideoxynucleosides / Q000009:adverse effects* / Q000627:therapeutic use*; D004342:Drug Hypersensitivity / Q000235:genetics*; D005006:Ethnicity; D005260:Female; D005820:Genetic Testing; D015658:HIV Infections / Q000188:drug therapy*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D000099227:Abacavir
D015224:Dideoxynucleosides; D015235:HLA-B Antigens; D000099227:Abacavir; C484830:HLA-B*57:01 antigen