Boy born after gender preselection following successive gestational androgen excess of maternal luteoma and female disorders of sex development.
OBJECTIVE
To present male gender preselection after successive gestational hyperandrogenism and female pseudohermaphroditism by pregnancy luteomas.


METHODS
Case report.


METHODS
University-based teaching hospital.


METHODS
We describe herein a gravida who presented two successive 46, XX disorders of sex development with apparent female genitalia with an enlarged clitoris due to maternal androgen excess from pregnancy luteoma. The maternal hyperandrogenemia returned to a normal level and bilateral luteoma regressed spontaneously postpartum. After gender preselection by Y-bearing spermatozoa for intrauterine insemination at the third gestation, a healthy boy was born in spite of the exaggerated maternal androgen production of pregnancy luteoma to avoid 46, XX disorders of sex development.


METHODS
Y-bearing spermatozoa for intrauterine insemination as male gender preselection.


METHODS
Boy born after gender preselection for intrauterine insemination and cesarean section.


RESULTS
Healthy boy born without disorder of sex development after antenatal maternal androgen excess of ovarian luteoma.


CONCLUSIONS
Successive pregnancy luteomas associated with maternal hyperandrogenism may cause female disorders of sex development. Male preselection ameliorates the insult of external genitalia ambiguity by antenatal androgen excess in this matter of concern.
Chen
Chi-Huang
CH
Department of Obstetrics and Gynecology, Tri-Service General Hospital, National Defense Medical Center, Taiwan. chihuangndmc@yahoo.com
Chen
I-Ching
IC
Wang
Yu-Chi
YC
Liu
Jah-Yao
JY
Wu
Gwo-Jang
GJ
Tzeng
Chii-Ruey
CR
D002585:Cesarean Section; D041322:Chromosomes, Human, Y; D012734:Disorders of Sex Development / Q000235:genetics*; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000150:complications; D018311:Luteoma / Q000150:complications*; D008297:Male; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic