Dopamine release in the human striatum: motor and cognitive tasks revisited.
Striatal dopamine (DA) release has been shown during behavioural tasks, but the relative contribution of motor, reward, and cognitive components is unclear. Dopamine release was quantified using [(11)C]-raclopride in two studies using a triple-scan approach, comprising active task, motor control, and rest. In the first, bolus radiotracer was delivered during a sequential motor learning paradigm; in the second, a spatial planning task, bolus plus constant infusion was applied. [(11)C]-raclopride binding potentials (BP(ND)s) in striatal functional subdivisions were compared across conditions. [(11)C]-raclopride BP(ND) was significantly reduced in active task compared with rest in both the sensorimotor and associative striatum in both studies, because of differences between rest and motor control conditions. In both regions, the motor control BP(ND) fell between the rest and active task in the planning study, but the difference between motor control and active task conditions was not significant. No such changes were observed in the limbic striatum. Using rigorous methodology, this study validates earlier evidence that striatal DA release occurs during behavioural challenges. Increased DA release during movement was reliably detected in the sensorimotor and associative striatum, supporting use of the functional subdivision model in humans. No additional DA release was observed specific to the cognitive component of either task.
Lappin
Julia M
JM
Institute of Psychiatry, King's College London, London, UK. j.lappin@iop.kcl.ac.uk
Reeves
Suzanne J
SJ
Mehta
Mitul A
MA
Egerton
Alice
A
Coulson
Mark
M
Grasby
Paul M
PM
D000328:Adult; D000368:Aged; D002250:Carbon Radioisotopes; D003071:Cognition / Q000502:physiology*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000008:administration & dosage; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009043:Motor Activity / Q000502:physiology*; D049268:Positron-Emission Tomography; D011597:Psychomotor Performance / Q000502:physiology; D020891:Raclopride / Q000008:administration & dosage
D002250:Carbon Radioisotopes; D018492:Dopamine Antagonists; D020891:Raclopride; D004298:Dopamine