title: The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum.
abstract: The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.
authors.affiliation: Department of Forest and Forest Product Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
authors.forename: Sri
authors.initials: S
authors.lastname: Fatmawati
authors.forename: Kenji
authors.initials: K
authors.lastname: Kurashiki
authors.forename: Sayaka
authors.initials: S
authors.lastname: Takeno
authors.forename: Yong-Ung
authors.initials: YU
authors.lastname: Kim
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Masao
authors.initials: M
authors.lastname: Sato
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imaizumi
authors.forename: Kaori
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shinji
authors.initials: S
authors.lastname: Kamiya
authors.forename: Shuhei
authors.initials: S
authors.lastname: Kaneko
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Kondo
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004376:Galactitol / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020940:Reishi / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D004376:Galactitol; D000449:Aldehyde Reductase