Soluble CD26 and CD30 plasma levels in HIV infected patients with and without GB virus type C coinfection.
GB virus type C (GBV-C) probably influences HIV infection associated disease by either directly inhibiting HIV replication or enhancing the immune competence to cope with HIV. Still the definitive mechanisms of this inhibitory effect need to be identified. To address the possibility of immune modulating effects of GBV-C coinfection in HIV patients we evaluated plasma levels of soluble (s) CD26 and CD30 in HIV infected patients with and without GBV-C. Cross-sectional comparison of sCD26 and sCD30 levels among 6 HIV/GBV-C coinfected, 11 HIV mono-infected and 13 healthy controls was carried out. We used a commercial EIA to evaluate sCD26 and scD30 and a RT-PCR assay to detect active GBV-C infection. The Mann-Whitney U test was used for statistical analysis. No statistically significant differences were observed in levels of sCD26 and sCD30 in plasma of HIV infected patients with and without GBV-C viremia. GBV-C infection does not appear to influence the sCD26 and sCD30 levels.
Mostafa
Haji-Molla-Hoseini
HM
Department of Immunology, School of Medicine, Tarbiat Modarres University, P.O. Box 14115-111, Tehran, Iran.
Ali-Akbar
Pourfathollah
P
Zahra
Soheili
S
Minoo
Mohraz
M
Sedigheh
Amini
A
Mahnaz
Aghaiepour
A
Shahram
Samiee
S
Mahin
Nikoogoftar
N
Mina
Moghtadaie
M
D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D029407:GB virus C / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000276:immunology* / Q000821:virology; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D014766:Viremia / Q000150:complications / Q000276:immunology / Q000821:virology
D017931:DNA Primers; D017730:Ki-1 Antigen; D012367:RNA, Viral; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4