[Effect of pomegranate peel extracts on oxidative stress in restrained mice].
OBJECTIVE
To observe the protective effects of pomegranate peel extracts on oxidative stress in restrained mice.


METHODS
The liver injury model was established under 18 h restraint stress in mice. The protective effects were evaluated by assessing alanine aminotransferase (ALT) GSH and Malondialdehyde (MDA) levels in plasma and antioxidant capacities of liver were measured by using oxygen radical absorbance capacity (ORAC) assay.


RESULTS
Activities of ALT and levels of MDA were observed to decrease on pomegranate peel extracts treated mice as compared with restraint stress control group and antioxidant capacity in liver homogenization and the levels of GSH in plasma significantly increased as compared with restraint stress.


CONCLUSIONS
The results indicate that pomegranate peel extracts exert protective effects on oxidative stress in mice loaded with restraint stress, which may be related to its free radical scavenging activity and lipid peroxidation inhibitory effect.
Xu
Zhen-zhen
ZZ
Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, China.
Feng
Jin-he
JH
Lu
Hui-wen
HW
Bao
Li
L
Kurihara
Hiroshi
H
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D015415:Biomarkers / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D005978:Glutathione / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000097:blood / Q000209:etiology / Q000517:prevention & control*; D029561:Lythraceae / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D011897:Random Allocation; D017382:Reactive Oxygen Species / Q000378:metabolism; D013315:Stress, Psychological / Q000150:complications*
D000975:Antioxidants; D015415:Biomarkers; D004365:Drugs, Chinese Herbal; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; D000410:Alanine Transaminase; D005978:Glutathione