Urinary level of nickel and acute leukaemia in Chinese children.
The 8-hydroxy-2'-deoxyguanosine (8-OHdG), an oxidized nucleoside of DNA, not only is a widely used biomarker for the measurement of endogenous oxidative DNA damage but might also be a risk factor for many diseases including cancer. Metal exposure may play an important role in oxidative DNA damage among children. However, few studies on urinary 8-OHdG and metals have been conducted in children with acute leukemia. In the present study, urinary Ni and 8-OHdG were examined in 116 children with acute leukaemia (94 acute lymphoid leukaemia [ALL] and 22 acute myeloid leukaemia [AML]) and 51 healthy child controls. Our result showed that urinary Ni in acute leukaemia patients (ALL: 68.40 +/- 133.98, AML: 41.48 +/- 76.31 ng/mg creatinine) was significantly higher than that in controls (62.47 +/- 124.90 vs 17.63 +/- 46.17 ng/mg creatinine, P < 0.05). Similarly, the pretherapy level of urinary 8-OHdG in patients (ALL: 11.83 +/- 16.23, AML: 12.36 +/- 11.36 ng/mg creatinine) was significantly elevated compared with controls (11.92 +/- 15.42 vs 4.03 +/- 4.70 ng/mg creatinine, P < 0.05). Moreover, urinary 8-OHdG and urinary Ni showed a weak but significant association with increased risk of childhood leukaemia. The present study suggests that Ni may be an etiologic factor for childhood acute leukaemia by oxidative DNA damage.
Yang
Y
Y
Shanghai XinHua Hospital of Shanghai Jiao Tong University School of Medicine, Shanghai Institute for Pediatric Research, Shanghai Key Laboratory of Children's Environmental Health, Shanghai, China.
Jin
X M
XM
Yan
C H
CH
Tian
Y
Y
Tang
J Y
JY
Shen
X M
XM
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000704:Analysis of Variance; D015415:Biomarkers / Q000652:urine; D002648:Child; D002675:Child, Preschool; D002681:China; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D007223:Infant; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism / Q000652:urine*; D016015:Logistic Models; D008297:Male; D019216:Metals, Heavy / Q000652:urine; D019565:Metals, Light / Q000652:urine; D009532:Nickel / Q000652:urine*; D018384:Oxidative Stress; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000378:metabolism / Q000652:urine*
D015415:Biomarkers; D019216:Metals, Heavy; D019565:Metals, Light; D009532:Nickel; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine