Neutrophils in cystic fibrosis.
Lung injury in cystic fibrosis is caused by recurrent airway infection and inflammation. Neutrophils are important in combating these infections but are also the predominate cells involved in the inflammatory process. This review of neutrophils in cystic fibrosis describes the cellular mechanisms involved in their migration into the airways and their role in bacterial phagocytosis. We discuss the inflammatory process and its resolution and ultimately how neutrophil function can be modulated.
Downey
D G
DG
Adult Cystic Fibrosis Centre, Bristol Royal Infirmary, Bristol, UK. damian.downey@ubht.nhs.uk
Bell
S C
SC
Elborn
J S
JS
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002465:Cell Movement; D003550:Cystic Fibrosis / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D009504:Neutrophils / Q000473:pathology / Q000502:physiology*; D011480:Protease Inhibitors / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011480:Protease Inhibitors