[Effect of toxins of cyanobacteria of the Microcystis genus from the Shershnevo Reservoir on DNA, cell cycle, and apoptosis of bone marrow cells in CBA mice].
The effect of toxins of a Cyanobacterium sample of the Shershnevo Reservoir on DNA, which was presented by cyanobacteria of the Microcystis genera, on the bone marrow of male CBA mice (whose age was 3 months and weight 24 g) was evaluated. With intraperitoneal administration, LD50 and LD16 of this sample for male CBA mice were 48.4 and 42.1 mg/kg, respectively. Administration of Microcystis cyanobacterial sample from the Shershnevo Reservoir in doses of 1/10 of LD16 and 1/2 of LD16, and LD16 was found to cause a dose-dependent reduction in the number of bone marrow nucleated cells, a dose-dependent increase in the rate of cell apoptotic death, a reduction in the duration of a cell cycle (within the first 12 hours), which gave way to an increase in the duration of the cycle 24 hours after administration, a dose-dependent increase in the frequency of micronuclei in the murine bone marrow eryphrocytes, and a dose-dependent decrease in the polychromatophil/normochromatophil ratio in the murine bone marrow.
Triapitsyna
G A
GA
Safonova
E V
EV
Zholdakova
Z I
ZI
Sinitsyna
O O
OO
Deriabina
L V
LV
Kolomiets
I A
IA
Andreev
S S
SS
Iachmenev
V A
VA
Priakhin
E A
EA
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001427:Bacterial Toxins / Q000633:toxicity*; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D002453:Cell Cycle / Q000187:drug effects*; D000087522:Cyanobacteria Toxins; D004247:DNA / Q000187:drug effects*; D004195:Disease Models, Animal; D018876:Environmental Illness / Q000235:genetics* / Q000382:microbiology / Q000473:pathology; D008297:Male; D008387:Marine Toxins / Q000633:toxicity*; D051379:Mice; D008811:Mice, Inbred DBA; D052998:Microcystins / Q000633:toxicity*; D046931:Microcystis / Q000302:isolation & purification*; D009498:Neurotoxins; D012426:Russia; D014873:Water Pollutants / Q000032:analysis
D001427:Bacterial Toxins; D000087522:Cyanobacteria Toxins; D008387:Marine Toxins; D052998:Microcystins; D009498:Neurotoxins; D014873:Water Pollutants; D004247:DNA