title: Promoting physical activity in childhood cancer survivors: results from the Childhood Cancer Survivor Study.
abstract: BACKGROUND
  Although physical activity may modify the late effects of childhood cancer treatment, from 20% to 52% of adult survivors are sedentary. The authors of this report sought to identify modifiable factors that influence survivors' participation in physical activity.
  
  
  METHODS
  Structural equation modeling of data were derived from the Childhood Cancer Survivors Study of adult survivors (current mean age, 30.98 years; mean years since diagnosis, 23.74; mean age at diagnosis, 9.25 years) who were diagnosed between 1970 and 1986.
  
  
  RESULTS
  Approximately 40% of the variance in male survivors' recent participation versus nonparticipation in physical activity was explained directly and/or indirectly by self-reported health fears (P = .01), perceived primary-care physician (PCP) expertise (P = .01), baseline exercise frequency (P < or = .001), education level (P = .01), self-reported stamina (P = .01), cancer-related pain (P < or = .001), fatigue (P < or = .001), age at diagnosis (P = .01), cancer-related anxiety (P < or = .001), motivation (P = .01), affect (P = .01), and discussion of subsequent cancer risk with the PCP (P < or = .001) (N = 256; chi-square test statistic = 53.38; degrees of freedom [df] = 51; P = .38, Comparative Fit Index [CFI] = 1.000; Tucker Lewis Index [TLI] = 1.000; root mean square of approximation [RMSEA] = 0.014; weighted root mean square residual [WRMR] = 0.76). Thirty-one percent of the variance in women' recent physical activity participation was explained directly and/or indirectly by self-reported stamina (P < or = .001), fatigue (P = .01), baseline exercise frequency (P = .01), cancer-related pain (P < or = .001), cancer-related anxiety (P = .01), recency of visits with PCP (<0.001), quality of interaction with the PCP (P = .01), and motivation (P < or = .001; N = 366; chi-square test statistic = 67.52; df = 55; P = .12; CFI = 0.98; TLI = 0.98; RMSEA = 0.025; WRMR = 0.76).
  
  
  CONCLUSIONS
  Gender-tailored intervention strategies in which providers specifically target motivation, fear, and affect may support physical activity in childhood cancer survivors.
authors.affiliation: Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee 38105-2794, USA. cheryl.cox@stjude.org
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Cox
authors.forename: Michele
authors.initials: M
authors.lastname: Montgomery
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Oeffinger
authors.forename: Wendy
authors.initials: W
authors.lastname: Leisenring
authors.forename: Lonnie
authors.initials: L
authors.lastname: Zeltzer
authors.forename: John A
authors.initials: JA
authors.lastname: Whitton
authors.forename: Ann C
authors.initials: AC
authors.lastname: Mertens
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Robison
mesh_terms: D000328:Adult; D000339:Affect; D001007:Anxiety; D005221:Fatigue; D005239:Fear; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D009042:Motivation; D009043:Motor Activity; D009369:Neoplasms / Q000628:therapy*; D012737:Sex Factors; D017741:Survivors