[A case of ovarian cancer in which a remarkable effect was seen with intrathoracic administration of CDDP and CPT-11].
A-58-year-old female admitted to our hospital for abdominal fullness and dyspnea was diagnosed with malignant pleuro-peritonitis of advanced ovarian cancer. CT showed a massive right-sided pleural effusion, massive ascites, and large ovarian tumor (about 10 x 15 cm). The patient was treated with intrathoracic administration of CDDP and CPT-11. Combination chemotherapy of CDDP (10 mg/week) and CPT-11 (10 mg/week) was administered by intrapleural injection every other week. As a result (total amount; CDDP 310 mg, CPT-11 250 mg, in 9 months), pleural effusion and ascites disappeared. Moreover, marked shrinkage (about 3 x 4 cm) of the tumor was confirmed. This intrathoracic administration of CDDP and CPT-11 may be an effective loco-regional therapy for advanced ovarian cancer with malignant pleuro-peritonitis.
Tokumitsu
Seiji
S
Dept. of Internal Medicine, Kousei Hospital.
Oka
Hiroaki
H
Nozaki
Akira
A
Kanazawa
Takeo
T
Mukohara
Yasuko
Y
Matsubara
Masahide
M
Matsushita
Kenji
K
Tsunashima
Takehiko
T
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007267:Injections; D000077146:Irinotecan; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D013909:Thorax; D014057:Tomography, X-Ray Computed
D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin