title: Direct preparation of unsymmetrical difunctionalized cyclen derivatives by an Ugi multicomponent reaction.
abstract: A new and efficient synthetic protocol for the preparation of unsymmetrical difunctionalized cyclen and its close derivatives using a modified Ugi reaction (N-split Ugi) is described. The scope of this methodology is further extended by the successful use of various isocyanides, highly functionalized carboxylic acids, and aldehydes.
authors.affiliation: Institute of Medicinal Chemistry, University of Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino (PU), Italy. giovanni.piersanti@uniurb.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Piersanti
authors.forename: Francesco
authors.initials: F
authors.lastname: Remi
authors.forename: Vieri
authors.initials: V
authors.lastname: Fusi
authors.forename: Mauro
authors.initials: M
authors.lastname: Formica
authors.forename: Luca
authors.initials: L
authors.lastname: Giorgi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Zappia
mesh_terms: D000080027:Cyclams; D003959:Diamines / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000080027:Cyclams; D003959:Diamines; D006571:Heterocyclic Compounds; C038072:cyclen