title: Expression of transforming growth factor beta1 in ameloblastomas.
abstract: The aim of the present study was to compare the expression of transforming growth factor (TGF) beta1 in ameloblastomas (AMs) with different risk of recurrence by immunohistochemistry. A total of 29 cases of AMs were evaluated. The tumors were divided into 2 groups: group A (10 cases) composed of unicystic and peripheral AMs, associated with a low risk of recurrence, and group B (19 cases) composed of solid AMs, associated with a high risk of recurrence. Statistical evaluation showed significant differences between groups A and B lesions, with higher values of positivity for TGF-beta1 in stromal cells in group B tumors (P = 0.0308). No statistically significant differences of immunoreactivity were found in vessels and odontogenic epithelium between the 2 groups. The increased TGF-beta1 expression in tumors with a high risk of recurrence could be explained with the fact that although TGF-beta acts as a potent tumor suppressor in the early stages of tumor progression, later it seems to enhance the invasive phenotype of the tumor.
authors.affiliation: Dental School, University of Chieti-Pescara, Italy.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Iezzi
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Luciano
authors.initials: L
authors.lastname: Artese
authors.forename: Gaia
authors.initials: G
authors.lastname: Goteri
authors.forename: Vittoria
authors.initials: V
authors.lastname: Perrotti
authors.forename: Francesco
authors.initials: F
authors.lastname: Carinci
mesh_terms: D000564:Ameloblastoma / Q000145:classification / Q000473:pathology*; D001808:Blood Vessels / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D017154:Stromal Cells / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000032:analysis*
chemical_list: D053773:Transforming Growth Factor beta1