title: Mo(CO)6-mediated intramolecular Pauson-Khand reaction of substituted diethyl 3-allyloxy-1-propynylphosphonates.
abstract: Cyclisation of diethyl 3-allyloxy-1-propynylphosphonates with Mo(CO)(6) under PK conditions to give 3-substituted-5-oxo-3,5,6,6a-tetrahydro-1H-cyclopenta[c]furan-4-ylphosphonate, 2a-h, in 45-88% isolated yields was done. The R groups are always syn with H(b) (where applicable). The stereochemistry was determined via both NMR and crystal X-ray analysis.
authors.affiliation: Department of Medicinal Chemistry and Natural Products, Hebrew University in Jerusalem, Jerusalem 91120, Israel.
authors.forename: Dorit
authors.initials: D
authors.lastname: Moradov
authors.forename: Abed Al Aziz
authors.initials: AA
authors.lastname: Al Quntar
authors.forename: Manar
authors.initials: M
authors.lastname: Youssef
authors.forename: Reem
authors.initials: R
authors.lastname: Smoum
authors.forename: Abraham
authors.initials: A
authors.lastname: Rubinstein
authors.forename: Morris
authors.initials: M
authors.lastname: Srebnik
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis*; D002248:Carbon Monoxide / Q000737:chemistry; D018360:Crystallography, X-Ray; D003500:Cyclization; D008024:Ligands; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000480:Alkynes; D019086:Bridged Bicyclo Compounds, Heterocyclic; D008024:Ligands; D063065:Organophosphonates; C022030:methylacetylene; D002248:Carbon Monoxide; D008982:Molybdenum