New members of mammalian aquaporins: AQP10-AQP12.
Thirteen members of mammalian aquaporins have been identified. Initial ten members (AQP-AQP9) are relatively well detailed and their roles are clarified. However, the last three members, AQP10-AQP12, are poorly characterized and little is known about their roles though they were cloned 6 years ago. In this review, we focus on these three AQPs. AQP10 is an aquaglyceroporin while AQP11 and AQP12 belong to a new subfamily, superaquaporins. Knockout mice for these aquaporins are now available. The AQP11 null mouse has a remarkable phenotype, polycystic kidneys, which is neonatally fatal. On the other hand, the absence of the other two affected little. In some animals, AQP10 is even a pseudogene. This review summarizes the current knowledge on these AQPs and will hopefully stimulate future research on the subject.
Ishibashi
Kenichi
K
Department of Medical Physiology, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo, 204-8588, Japan. kishiba@my-pharm.ac.jp
D000818:Animals; D051397:Aquaglyceroporins / Q000378:metabolism; D020346:Aquaporins / Q000235:genetics / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000378:metabolism; D005838:Genotype; D006801:Humans; D007668:Kidney / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D010179:Pancreas / Q000378:metabolism; D010641:Phenotype; D007690:Polycystic Kidney Diseases / Q000235:genetics / Q000378:metabolism
C501068:AQP12 protein, mouse; C503878:Aqp11 protein, mouse; D051397:Aquaglyceroporins; D020346:Aquaporins