Wound healing activity of Sesamum indicum L seed and oil in rats.
The seeds of S. indicum L (Pedaliaceae) are used traditionally in the folklore for the treatment of various kinds of wounds. The present study was undertaken to verify the effect of S. indicum seeds and its oil on experimentally induced excision wound, incision wound, burn wound and dead space wound models in rats. Aloe vera was used as standard wound healing agent. A formulation of seeds and oil was prepared in carbopol at 2.5% and 5% concentrations and applied to the wounds. In the excision and burn wound models, the so treated animals showed significant reduction in period of epithelization and wound contraction (50%). In the incision wound model a significant increase in the breaking strength was observed. Seeds and oil treatment (250 mg and 500 mg/kg; po) in dead space wound model, produced a significant increase in the breaking strength, dry weight and hydroxyproline content of the granulation tissue. The results suggest that S. indicum seeds and oil applied topically or administered orally possesses wound healing activity.
Kiran
Kotade
K
Department of Pharmacology, Krupanidhi College of Pharmacy, 5, Sarjapur Road, Koramangala, Bangalore 560 034, India.
Asad
Mohammed
M
D000284:Administration, Oral; D000504:Aloe / Q000378:metabolism; D000818:Animals; D002056:Burns / Q000188:drug therapy*; D004848:Epithelium / Q000378:metabolism; D006909:Hydroxyproline / Q000737:chemistry; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D010938:Plant Oils / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000378:metabolism*; D031685:Sesamum / Q000378:metabolism*; D014945:Wound Healing; D014950:Wounds, Penetrating / Q000188:drug therapy
D010936:Plant Extracts; D010938:Plant Oils; D006909:Hydroxyproline