title: An increase in the diagnosis rate of early colorectal cancer by sample targeting using stereomicroscopy: a two-year experience with 196 cases.
abstract: OBJECTIVE
  To analyze the utility of stereomicroscopic evaluation for the diagnosis of early colorectal cancer using pit patterns and sample targeting and localized biopsy and the relationship between subclassification of the type IIIL pit pattern and histopathology.
  
  
  METHODS
  A total of 196 colorectal neoplasms (including 110 colorectal neoplasms with type-IIIL pit pattern) were completely resected endoscopically and observed by stereomicroscopy from August 2005 to July 2007. The histopathological results of the suspicious parts with pit patterns associated with early colorectal cancer under stereomicroscopy were compared with conventional pathological examinations slicing the entire specimen at random. We divided neoplasms with a type-IIIL pit pattern into three subclasses (IIIL-A IIIL-B and IIIL-C), according to the morphologic and prominent stereomicroscopy findings. We examined the relation between these three subclasses and histology.
  
  
  RESULTS
  The diagnosis rate of early colorectal cancer was 33.7% (66/196) by targeted and localized biopsy under stereomicroscopy, whereas it was only 6.1% (12/196) by conventional pathological examination (P<0.001). Subtype IIIL-C are significant predictors for early colorectal cancer.
  
  
  CONCLUSIONS
  Sample targeting and localized biopsy under stereomicroscopy and subclassification of the type IIIL pit pattern is useful for improving the diagnosis rate of early colorectal cancer.
authors.affiliation: Department of Gastroenterology, Nanfang Hospital Southern Medical University, Guangzhou 510515, Guangdong Province, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Hu
authors.forename: Xinying
authors.initials: X
authors.lastname: Wang
authors.forename: Xinyan
authors.initials: X
authors.lastname: Pan
authors.forename: Yan
authors.initials: Y
authors.lastname: Geng
authors.forename: Yali
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003581:Cytodiagnosis / Q000379:methods*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008853:Microscopy / Q000379:methods*; D008875:Middle Aged