Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species.
With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC(50) values between 0.15-1.42 microM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.
Fernandez
Liza S
LS
Eskitis Institute, Griffith University, Brisbane, QLD 4111 Australia.
Buchanan
Malcolm S
MS
Carroll
Anthony R
AR
Feng
Yun Jiang
YJ
Quinn
Ronald J
RJ
Avery
Vicky M
VM
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010271:Parasites / Q000187:drug effects / Q000254:growth & development; D027821:Rutaceae / Q000737:chemistry*
D000962:Antimalarials; D026121:Indole Alkaloids; C538846:flinderole A; C538847:flinderole B; C538848:flinderole C