title: The quality of life of children and adolescents with X-linked agammaglobulinemia.
abstract: BACKGROUND
  The health-related quality of life in X-linked agammaglobulinemia was investigated in 25 children and adolescents patients through the Italian version of Pediatric Quality of Life Inventory 4.0 Generic Core Scale for patients aged less then 18 years, comparing child perception to that of the parents and the physician's evaluation. The data were compared with the ones of 80 healthy controls and the literature data of a group of patients with rheumatic diseases.
  
  
  CONCLUSIONS
  The agammaglobulinemia subjects perceived a lower global quality of life than the healthy subjects, but significantly higher than the rheumatic diseases controls. The clinical relevance of health-related quality of life assessment in X-linked agammaglobulinemia pediatric patients is discussed.
authors.affiliation: Dipartimento di Pediatría, Università degli Studi di Brescia, 25123 Brescia, Italy. soresina@med.unibs.it
authors.forename: Annarosa
authors.initials: A
authors.lastname: Soresina
authors.forename: Renata
authors.initials: R
authors.lastname: Nacinovich
authors.forename: Monica
authors.initials: M
authors.lastname: Bomba
authors.forename: Morena
authors.initials: M
authors.lastname: Cassani
authors.forename: Anna
authors.initials: A
authors.lastname: Molinaro
authors.forename: Antonella
authors.initials: A
authors.lastname: Sciotto
authors.forename: Silvana
authors.initials: S
authors.lastname: Martino
authors.forename: Fabio
authors.initials: F
authors.lastname: Cardinale
authors.forename: Domenico
authors.initials: D
authors.lastname: De Mattia
authors.forename: Caterina
authors.initials: C
authors.lastname: Putti
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Dellepiane
authors.forename: Leonardo
authors.initials: L
authors.lastname: Felici
authors.forename: Giovanni
authors.initials: G
authors.lastname: Parrinello
authors.forename: Francesca
authors.initials: F
authors.lastname: Neri
authors.forename: Alessandro
authors.initials: A
authors.lastname: Plebani
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000361:Agammaglobulinemia / Q000188:drug therapy / Q000235:genetics / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000188:drug therapy / Q000235:genetics / Q000523:psychology*; D006304:Health Status; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009154:Mutation / Q000235:genetics; D010290:Parents; D011788:Quality of Life; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
chemical_list: D016756:Immunoglobulins, Intravenous