Spinal epidural granulocytic sarcoma in non-leukemic patient.
A previously healthy 24-year-old male presented with a 3-month history of progressive backache and weakness in both legs. Magnetic resonance imaging of the spine showed a large soft tissue mass infiltrating paraspinal musculature of lumbosacral area, sacral laminas, last lumbar and all sacral vertebra, protruding into the spinal canal, and with propagation into pelvis. Baseline laboratory data were normal. Decompressive laminectomy and tumor removal were performed resulting in neurological improvement. Histological examination identified granulocytic sarcoma (GS). Bone marrow biopsy showed normal findings. The patient underwent adjuvant chemotherapy and radiotherapy, resulting in the elimination of residual lesion, followed by autologous transplant. Immediate diagnosis and adequate systematic treatment are essential to achieve optimal results in patients with isolated GS. The patient is alive and free of the disease 14 months from the diagnosis.
Antic
Darko
D
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia. tweety@net.yu.
Verstovsek
Srdan
S
Leukemia Department, MD Anderson Cancer Center, Houston, TX, USA.
Elezovic
Ivo
I
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia.
Grujicic
Dana
D
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia.
Gotic
Mirjana
M
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia.
Bila
Jelena
J
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia.
Perunicic
Maja
M
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia.
Jakovic
Ljubomir
L
Institute of Hematology, Clinical Center of Serbia, Koste Todorovica 2, 11000, Belgrade, Serbia.
D018572:Disease-Free Survival; D015174:Epidural Neoplasms / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D016130:Immunophenotyping; D008279:Magnetic Resonance Imaging; D008297:Male; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000628:therapy; D055815:Young Adult