title: CT-guided radiofrequency ablation in the treatment of recurrent rectal cancer.
abstract: OBJECTIVE
  Locally recurrent rectal adenocarcinoma remains a therapeutic challenge that is unsatisfactorily managed by surgery and radiation therapy or chemotherapy. Palliative CT-guided radiofrequency ablation was used in 14 patients with recurrent rectal adenocarcinoma who had been previously treated with abdominoperineal resection and radiation therapy. Follow-up CT or MRI was performed at 3, 6, 12, and 24 months. Pain palliation was monitored by the brief pain inventory (BPI).
  
  
  CONCLUSIONS
  One month after radiofrequency ablation, 11 patients reported satisfactory BPI mean scores reduction compared to baseline (from 7.6 to 3.4 and from 5.1 to 1.6 for worst and average pain, respectively). In two unresponsive patients, retreatment was successfully performed at 3 months. After 24 months, worst and average pain scores further decreased (to 2.6 and 0.8, respectively) in 10 patients, who, at imaging, showed an ablation zone covering the entire original lesion in two patients and incomplete ablation in eight. In our experience, radiofrequency ablation is a safe and effective palliative treatment for patients with recurrent rectal adenocarcinoma.
authors.affiliation: Department of Diagnostic Imaging, S. Anna-S. Sebastiano Hospital, Via F. Palasciano, 81100, Caserta, Italy. radospce@libero.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Belfiore
authors.forename: Enrico
authors.initials: E
authors.lastname: Tedeschi
authors.forename: Francesco Michele
authors.initials: FM
authors.lastname: Ronza
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Belfiore
authors.forename: Ettore
authors.initials: E
authors.lastname: Borsi
authors.forename: Giovanni Pietro
authors.initials: GP
authors.lastname: Ianniello
authors.forename: Antonio
authors.initials: A
authors.lastname: Rotondo
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000601:surgery*; D000368:Aged; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging* / Q000601:surgery*; D012004:Rectal Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome