title: [Pulmonary function testing in Chinese patients with pulmonary arterial hypertension].
abstract: OBJECTIVE
  To determine the diagnostic value of pulmonary function testing in Chinese patients with known pulmonary arterial hypertension (PAH) without history of lung/heart valve diseases.
  
  
  METHODS
  Pulmonary function testing was performed in 41 PAH patients diagnosed by right heart catheterization and in 17 healthy controls.
  
  
  RESULTS
  Normal pulmonary function testing results were found in 5 PAH patients (12.2%). Total lung capacity, vital capacity and FEV1 were significantly decreased in PAH patients [(80.27 +/- 11.46)% vs. (94.24 +/- 6.82)%; (79.09 +/- 14.89)% vs. (97.35 +/- 9.51)%; (75.40 +/- 16.58)% vs. (95.12 +/- 12.01)%, respectively, all P < 0.001], the ratio of residual volume/total lung capacity was significantly increased [(117.67 +/- 25.73)% vs. (93.39 +/- 10.87)%, P < 0.001]; FEV1/FVC and maximal expiratory flow of 25% to 75% tended to be lower (-6.0% and -19.4%, P = 0.21 and 0.09) while DLCO and DLCO/VA were significantly decreased by 36.6% and 29.8% (P < 0.001) compared with healthy controls.
  
  
  CONCLUSIONS
  Increased peripheral airway obstruction and normal lung resistance were found in these PAH patients. Normal pulmonary function testing results could not rule out the diagnosis of PAH.
authors.affiliation: Department of Internal Medicine, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China. jingzhicheng@medmail.com.cn
authors.forename: Zhi-Cheng
authors.initials: ZC
authors.lastname: Jing
authors.forename: Xi-Qi
authors.initials: XQ
authors.lastname: Xu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Zhao
authors.forename: Xiong
authors.initials: X
authors.lastname: Luo
authors.forename: Li
authors.initials: L
authors.lastname: Zhai
authors.forename: Xin
authors.initials: X
authors.lastname: Jiang
authors.forename: Hao
authors.initials: H
authors.lastname: Lu
authors.forename: Jin-Hu
authors.initials: JH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011653:Pulmonary Diffusing Capacity; D012129:Respiratory Function Tests; D014797:Vital Capacity