Long-term depression of excitatory synaptic transmission in rat hippocampal CA1 neurons following sleep-deprivation.
In rat hippocampal CA1 neurons, excitatory synaptic transmission is depressed following a 20 Hz, 30 s stimulation in the stratum radiatum. This depression lasts for at least 25 min post-tetanus (long-term depression, LTD). The LTD is significantly enhanced by about 20% if rats were sleep-deprived for 12 h prior to recording. The increase in LTD following sleep-deprivation is a new finding which can have implications for hippocampal neuronal excitability, network activity, and induction of long-term potentiation and may account for post-sleep deprivation amnesia.
Tadavarty
R
R
Neuroscience Research Laboratory, Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, Vancouver, BC, Canada.
Kaan
T K Y
TK
Sastry
B R
BR
D000200:Action Potentials / Q000502:physiology; D000647:Amnesia / Q000209:etiology / Q000503:physiopathology; D000818:Animals; D004195:Disease Models, Animal; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology*; D006624:Hippocampus / Q000503:physiopathology*; D007858:Learning / Q000502:physiology; D036881:Long-Term Synaptic Depression / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology; D009415:Nerve Net / Q000503:physiopathology; D009474:Neurons / Q000502:physiology*; D009924:Organ Culture Techniques; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation / Q000150:complications / Q000503:physiopathology*; D009435:Synaptic Transmission / Q000502:physiology