Biodegradable multiblock copolymers based on oligodepsipeptides with shape-memory properties.
Thermoplastic phase-segregated multiblock copolymers with polydepsipeptides and PCL segments were prepared via coupling of diol and PCL-diol using an aliphatic diisocyanate. The obtained multiblock copolymers showed good elastic properties and a shape memory. Almost complete fixation of the mechanical deformation, resulting in quantitative recovery of the permanent shape with a switching temperature around body temperature, was observed. In hydrolytic degradation experiments, a quick decrease of the molecular weight without induction period was observed, and the material changed from elastic to brittle in 21 d. These materials promise a high potential for biomedical applications such as smart implants or medical devices.
Feng
Yakai
Y
Department of Polymer Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China.
Behl
Marc
M
Kelch
Steffen
S
Lendlein
Andreas
A
D001672:Biocompatible Materials / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry* / Q000235:genetics; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D013314:Stress, Mechanical
D001672:Biocompatible Materials; D009842:Oligopeptides; D011108:Polymers