title: Distributed Drug Discovery, Part 3: using D(3) methodology to synthesize analogs of an anti-melanoma compound.
abstract: For the successful implementation of Distributed Drug Discovery (D(3)) (outlined in the accompanying Perspective), students, in the course of their educational laboratories, must be able to reproducibly make new, high quality, molecules with potential for biological activity. This article reports the successful achievement of this goal. Using previously rehearsed alkylating agents, students in a second semester organic chemistry laboratory performed a solid-phase combinatorial chemistry experiment in which they made 38 new analogs of the most potent member of a class of antimelanoma compounds. All compounds were made in duplicate, purified by silica gel chromatography, and characterized by NMR and LC/MS. As a continuing part of the Distributed Drug Discovery program, a virtual D(3) catalog based on this work was then enumerated and is made freely available to the global scientific community.
authors.affiliation: Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, Indianapolis, Indiana 46202-3274, USA. wscott@iupui.edu
authors.forename: William L
authors.initials: WL
authors.lastname: Scott
authors.forename: Christopher O
authors.initials: CO
authors.lastname: Audu
authors.forename: Jeffery L
authors.initials: JL
authors.lastname: Dage
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Goodwin
authors.forename: Jacek G
authors.initials: JG
authors.lastname: Martynow
authors.forename: Laura K
authors.initials: LK
authors.lastname: Platt
authors.forename: Judith G
authors.initials: JG
authors.lastname: Smith
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Strong
authors.forename: Kirk
authors.initials: K
authors.lastname: Wickizer
authors.forename: Eric M
authors.initials: EM
authors.lastname: Woerly
authors.forename: Martin J
authors.initials: MJ
authors.lastname: O'Donnell
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D035843:Biomedical Research / Q000193:education*; D055808:Drug Discovery / Q000379:methods*; D007753:Laboratories; D008545:Melanoma / Q000188:drug therapy*; D014495:Universities
chemical_list: D000970:Antineoplastic Agents