title: Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials.
abstract: A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of beta-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodium falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 microg/mL.
authors.affiliation: Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, UP 226001, India.
authors.forename: Mridul
authors.initials: M
authors.lastname: Misra
authors.forename: Swaroop Kumar
authors.initials: SK
authors.lastname: Pandey
authors.forename: Vivek Parashar
authors.initials: VP
authors.lastname: Pandey
authors.forename: Jyoti
authors.initials: J
authors.lastname: Pandey
authors.forename: Renu
authors.initials: R
authors.lastname: Tripathi
authors.forename: Rama Pati
authors.initials: RP
authors.lastname: Tripathi
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D011725:Pyridines