title: Progression to impaired glucose regulation and diabetes in the population-based Inter99 study.
abstract: OBJECTIVE
  The purpose of this study was to estimate the progression rates to impaired glucose regulation (impaired fasting glucose or impaired glucose tolerance) and diabetes in the Danish population-based Inter99 study and in a high-risk subpopulation, separately.
  
  
  METHODS
  From a population-based primary prevention study, the Inter99 study, 4,615 individuals without diabetes at baseline and with relevant follow-up data were divided into a low- and a high-risk group based on a risk estimate of ischemic heart disease or the presence of risk factors (smoking, hypertension, hypercholesterolemia, obesity, or impaired glucose tolerance). High-risk individuals (57.1%) were examined with an oral glucose tolerance test at 1 and 3 years, and all of the participants were reexamined at the 5-year follow-up. Person-years at risk were calculated. Progression rates to impaired glucose regulation and diabetes were estimated directly from baseline to the 5-year follow-up for all the participants and from baseline through the 1- and 3- to 5-year follow-up examinations for the high-risk individuals, separately.
  
  
  RESULTS
  In the combined low- and high-risk group, 2.1 individuals per 100 person-years progressed from normal glucose tolerance (NGT) to impaired glucose regulation or diabetes. Among high-risk individuals, 5.8 per 100 person-years with NGT progressed to impaired glucose regulation or diabetes, and 4.9 per 100 person-years progressed from impaired glucose regulation to diabetes.
  
  
  CONCLUSIONS
  Progression rates to impaired glucose regulation using the current World Health Organization classification criteria were calculated for the first time in a large European population-based study. The progression rates to diabetes show the same pattern as seen in the few similar European studies.
authors.affiliation: Steno Diabetes Center, Gentofte, Denmark. segb@steno.dk
authors.forename: Susanne
authors.initials: S
authors.lastname: Engberg
authors.forename: Dorte
authors.initials: D
authors.lastname: Vistisen
authors.forename: Cathrine
authors.initials: C
authors.lastname: Lau
authors.forename: Charlotte
authors.initials: C
authors.lastname: Glümer
authors.forename: Torben
authors.initials: T
authors.lastname: Jørgensen
authors.forename: Oluf
authors.initials: O
authors.lastname: Pedersen
authors.forename: Knut
authors.initials: K
authors.lastname: Borch-Johnsen
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003718:Denmark / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000453:epidemiology*; D003925:Diabetic Angiopathies / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000453:epidemiology* / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000453:epidemiology; D011322:Primary Prevention; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires; D013997:Time Factors; D044465:White People
chemical_list: D001786:Blood Glucose