title: [Tongxinluo improves vascular endothelial function in patients with type 2 diabetes].
abstract: OBJECTIVE
  To investigate the effects of Tongxinluo on vascular endothelial function in patients with type 2 diabetes.
  
  
  METHODS
  A total of 80 patients with type 2 diabetes were recruited and divided into two groups: Tongxinluo therapy group (n = 40) and conventional therapy group (n = 40). Plasma levels of NO, ET, 6-keto-PGF1alpha and TXB2 and diastolic functions of humeral arteries (measured by high-resolution ultrasound) were measured at baseline and 4 weeks later.
  
  
  RESULTS
  The flow-mediated dilation was significantly increased from (8.19 +/- 0.71)% to (12.47 +/- 0.98)% (P < 0.05) in Tongxinluo therapy group after 4 weeks therapy compare to baseline level. Their plasma NO was significantly increased [(47.65 +/- 4.38) pg/ml to (52.91 +/- 4.83) pg/ml, P < 0.001] and plasma ET significantly reduced [(31.23 +/- 2.46) pg/ml to (24.34 +/- 2.46) pg/ml, P < 0.001] post 4 week Tongxinluo therapy. Parameters remained unchanged in the placebo group (P > 0.05) at baseline and 4 weeks later. Non-flow-mediated dilation was unaffected by Tongxinluo therapy.
  
  
  CONCLUSIONS
  Tongxinluo improved the vascular endothelial dependent diastolic function in patients with type 2 diabetes by regulating the balance of plasma NO/ET.
authors.affiliation: Department of Cardiology, People's Hospital, Peking University, Beijing 100044, China. chenhong0418@yahoo.com.cn
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Shi-wei
authors.initials: SW
authors.lastname: Yang
authors.forename: Jing-yi
authors.initials: JY
authors.lastname: Ren
authors.forename: Cheng-bin
authors.initials: CB
authors.lastname: Xu
authors.forename: Bei
authors.initials: B
authors.lastname: Wu
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Li
mesh_terms: D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; D016232:Endothelins; C513941:tongxinluo; D009569:Nitric Oxide