title: Spin-echo echo-planar perfusion MR imaging in the differential diagnosis of solitary enhancing brain lesions: distinguishing solitary metastases from primary glioma.
abstract: Unlike the more widely reported gradient-echo echo-planar perfusion-weighted imaging (EPI-PWI) technique, spin-echo (SE) EPI relative cerebral blood volume maps select for blood volume in microvessels <8 microm in diameter. This first report of SE-EPI PWI for distinguishing brain metastasis from high-grade glioma demonstrated 88% sensitivity and 72% specificity in 83 patients. We discuss differences in microvessel architecture between high-grade glioma and brain metastasis that may explain the surprising success of SE-EPI in this application and may deserve further investigation.
authors.affiliation: Department of Radiology of Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. GSYOUNG@PARTNERS.ORG
authors.forename: G S
authors.initials: GS
authors.lastname: Young
authors.forename: K
authors.initials: K
authors.lastname: Setayesh
mesh_terms: D000230:Adenocarcinoma / Q000556:secondary; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000556:secondary; D015179:Colorectal Neoplasms / Q000473:pathology; D003937:Diagnosis, Differential; D017352:Echo-Planar Imaging; D004938:Esophageal Neoplasms / Q000473:pathology; D005260:Female; D005909:Glioblastoma / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000556:secondary; D008875:Middle Aged; D008959:Models, Neurological; D011471:Prostatic Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D012509:Sarcoma / Q000556:secondary*; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000473:pathology