title: Synthesis and structure-activity relationships of 2-phenyl-1-[(pyridinyl- and piperidinylmethyl)amino]-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents.
abstract: Continuous efforts on the synthesis and structure-activity relationships (SARs) studies of modified 1-benzylamino-2-phenyl-3-(1H-1,2,4-triazol-1-yl)propan-2-ols as antifungal agents, allowed identification of new 1-[(pyridinyl- and piperidinylmethyl)amino] derivatives with MIC(80) values ranging from 1410.0 to 23.0ngmL(-1) on Candidaalbicans. These results confirmed both the importance of pi-pi stacking and hydrogen bonding interactions in the active site of CYP51-C. albicans.
authors.affiliation: Université de Nantes, Nantes Atlantique Universités, Département de Pharmacochimie, Cibles et Médicaments des Infections, de l'Immunité et du Cancer, IICIMED-EA 1155, UFR de Sciences Pharmaceutiques, 1 rue Gaston Veil, Nantes F-44035 Cedex 1, France.
authors.forename: Francis
authors.initials: F
authors.lastname: Giraud
authors.forename: Rémi
authors.initials: R
authors.lastname: Guillon
authors.forename: Cédric
authors.initials: C
authors.lastname: Logé
authors.forename: Fabrice
authors.initials: F
authors.lastname: Pagniez
authors.forename: Carine
authors.initials: C
authors.lastname: Picot
authors.forename: Marc
authors.initials: M
authors.lastname: Le Borgne
authors.forename: Patrice
authors.initials: P
authors.lastname: Le Pape
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D020005:Propanols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D020005:Propanols