New potential inhibitors of DNA topoisomerase. Part II: Design and synthesis of alpha-lapachone derivatives under microwave irradiation.
A new series of potential inhibitors of DNA topoisomerase II were synthesized from facile materials (aromatic aldehydes, Meldrum's acid and 2-hydroxynaphthalene-1,4-dione) under microwave irradiation. The method provides a valuable tool in designing new and more potent cytotoxic analogues. This procedure is advantageous both economically and environmentally.
Wei
Ping
P
College of Life and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu, 210009, PR China.
Zhang
Xiaohong
X
Tu
Shujiang
S
Yan
Shu
S
Ying
Hanjie
H
Ouyang
Pingkai
P
D000970:Antineoplastic Agents / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007783:Lactones / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D008954:Models, Biological; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy; D012997:Solvents / Q000737:chemistry; D013696:Temperature; D013997:Time Factors; D059004:Topoisomerase I Inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007783:Lactones; D012997:Solvents; D059004:Topoisomerase I Inhibitors