Photodynamic therapy with aluminum-chloro-phthalocyanine induces necrosis and vascular damage in mice tongue tumors.
In this paper we describe the efficacy of the liposomal-AlClPc (aluminum-chloro-phthalocyanine) formulation in PDT study against Ehrlich tumor cells proliferation in immunocompetent swiss mice tongue. Experiments were conduced in sixteen tumor induced mice that were divided in three control groups: (1) tumor without treatment; (2) tumor with 100J/cm(2) laser (670nm) irradiation; and (3) tumor with AlClPc peritumoral injection; and a PDT experimental group when tumors received AlClPc injection followed by tumor irradiation. Control groups present similar macroscopically and histological patterns after treatments, while PDT treatment induced 90% of Ehrlich tumor necrosis after 24h of one single application, showing the efficacy of liposome-AlClPc (aluminum-chloro-phthalocyanine) mediated PDT on the treatment of oral cancer.
Longo
João Paulo Figueiró
JP
Department of Genetics and Morphology, Institute of Biology, University of Brasília, Brasília DF 70910-900, Brazil.
Lozzi
Silene Paulino
SP
Simioni
Andreza Ribeiro
AR
Morais
Paulo César
PC
Tedesco
Antônio Cláudio
AC
Azevedo
Ricardo Bentes
RB
D000818:Animals; D007211:Indoles / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008027:Light; D051379:Mice; D009336:Necrosis / Q000139:chemically induced; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010778:Photochemotherapy; D013696:Temperature; D014059:Tongue / Q000098:blood supply / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D014062:Tongue Neoplasms / Q000098:blood supply* / Q000188:drug therapy / Q000473:pathology*
D007211:Indoles; D009942:Organometallic Compounds; C044797:chloroaluminum phthalocyanine