Excretion of afobazole and its metabolites with urine and feces in rats.
The amount of afobazole and identified metabolites was measured in the urine and feces of rats after intraperitoneal and peroral administration of the drug in a dose of 25 mg/kg. Over 1 day after intraperitoneal or peroral treatment with afobazole, urine and feces contained 0.1% initial compound (from administered dose) and 42.1% metabolites.
Viglinskaya
A O
AO
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Kolyvanov
G B
GB
Litvin
A A
AA
Zherdev
V P
VP
Seredenin
S B
SB
D000818:Animals; D021461:Animals, Outbred Strains; D014151:Anti-Anxiety Agents / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics / Q000652:urine; D001562:Benzimidazoles / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005243:Feces / Q000737:chemistry*; D008297:Male; D009025:Morpholines / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics* / Q000652:urine*; D051381:Rats; D013997:Time Factors
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines