Function of aquaporin-7 in the kidney and the male reproductive system.
The aquaporin-7 (AQP7) water channel is known to be a member of the aquaglyceroporins, which allow the rapid transport of glycerol and water. In this chapter, we review the physiological functions of AQP7 in the kidney and the male reproductive system.In the kidney, AQP7 is abundantly present at the apical membrane of the proximal straight tubules. Although the contribution of AQP7 to the water permeability of proximal straight tubules was found to be minimal compared with that of AQP1, we identified a novel glycerol reabsorption pathway that may be important for preventing glycerol from being excreted into urine.In the male reproductive system, AQP7 is present particularly in the spermatids, as well as in the testicular and epididymal spermatozoa, suggesting that AQP7 has some role in late spermatogenesis. However, male AQP7 knockout mice were not sterile, and their sperm did not show any morphological or functional abnormalities.
Sohara
Eisei
E
Department of Nephrology, Graduate School of Medicine, Tokyo Medical and Dental University, Tokyo, Japan.
Uchida
Shinichi
S
Sasaki
Sei
S
D000818:Animals; D051397:Aquaglyceroporins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020346:Aquaporins / Q000378:metabolism; D005298:Fertility; D005837:Genitalia, Male / Q000378:metabolism* / Q000503:physiopathology; D005990:Glycerol / Q000378:metabolism*; D006801:Humans; D007248:Infertility, Male / Q000378:metabolism / Q000503:physiopathology; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D051381:Rats; D013091:Spermatogenesis; D013094:Spermatozoa / Q000378:metabolism; D014508:Urea / Q000378:metabolism; D014867:Water / Q000378:metabolism*
C114141:AQP7 protein, human; C491927:Aqp7 protein, mouse; C491926:Aqp7 protein, rat; D051397:Aquaglyceroporins; D020346:Aquaporins; D014867:Water; D014508:Urea; D005990:Glycerol