Immediate and long-term effects of glucomannan on total ghrelin and leptin in type 2 diabetes mellitus.
Effects of glucomannan as a supplementary treatment in type 2 diabetes mellitus were investigated by measuring ghrelin, leptin and insulin responses to OGTT. Glucomannan enhanced prandial ghrelin reduction when given before glucose load and impeded the rise of fasting ghrelin after 4-week supplement. Ghrelin-induced feeding may be attenuated by glucomannan.
Chearskul
S
S
Department of Physiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand. sisch@mahidol.ac.th
Kriengsinyos
W
W
Kooptiwut
S
S
Sangurai
S
S
Onreabroi
S
S
Churintaraphan
M
M
Semprasert
N
N
Nitiyanant
W
W
D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D019587:Dietary Supplements; D005215:Fasting / Q000097:blood / Q000378:metabolism; D054439:Ghrelin / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D020738:Leptin / Q000097:blood*; D008351:Mannans / Q000494:pharmacology*; D010919:Placebos; D019518:Postprandial Period / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D001786:Blood Glucose; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D008351:Mannans; D010919:Placebos; C022901:(1-6)-alpha-glucomannan