[Early embryogenesis in mammals: stem cells and first commitment steps].
In mammals, embryonic and extraembryonic cell lineages segregate during the first steps of cell differentiation in the preimplantation embryo. Indeed, mammal embryos contain very low energy stocks and thus get ready for implantation very early to be able to absorb nutrients from the mother, first through the yolk sac and then through the placenta. These first steps involve classical genetic and morphogenetic processes as well as specific mechanisms of early embryo development such as epigenetic reprogramming and maintenance of pluripotent cells. Embryo analysis led to the isolation of embryonic stem (ES) cells, granted by the 2007 Nobel prize of Medicine (to M. Evans, M. Capecchi and O. Smithies) and which offer strong hopes for cell therapy.
Chazaud
Claire
C
GReD (Génétique, Reproduction et Développement), CNRS, UMR 6247, Inserm, U931, Clermont Université, Faculté de médecine, 28 place H. Dunant, BP38, 63001 Clermont-Ferrand, France. claire.chazaud@u-clermont1.fr
D000818:Animals; D001755:Blastocyst / Q000166:cytology; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D047108:Embryonic Development / Q000502:physiology; D053595:Embryonic Stem Cells / Q000166:cytology*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D005855:Germ Layers / Q000166:cytology; D008322:Mammals / Q000235:genetics*; D051379:Mice; D011247:Pregnancy; D014327:Trophoblasts / Q000166:cytology; D015053:Zygote / Q000166:cytology