title: Ultrastructural changes in the small intestine of suckling mice, caused by vibrio cholerae hemagglutinin/protease.
abstract: Suckling mice aged 4-5 days were injected with Vibrio cholerae hemagglutinin/protease and ultrastructural changes in their small intestine were studied after 5 h. The preparation caused a statistically significant accumulation of fluid in the intestine, appearance of large gaps along cell-cell spaces in the villi and crypts, intense production and secretion of the mucus by goblet cells. The formation of interepithelial cavities was paralleled by vascular changes, supplemented by extravasal disorders caused by mast cell reaction. The role of enterochromaffin cells and lipofibroblasts, modulating the secretion in the intestine, is confirmed.
authors.affiliation: Laboratory of Pathomorphology and Pathophysiology, Plague Control Institute, Rostov-on-Don, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Bardakchian
authors.forename: E V
authors.initials: EV
authors.lastname: Monakhova
authors.forename: N G
authors.initials: NG
authors.lastname: Kharlanova
authors.forename: S R
authors.initials: SR
authors.lastname: Sayamov
authors.forename: R V
authors.initials: RV
authors.lastname: Pisanov
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D007421:Intestine, Small / Q000187:drug effects* / Q000648:ultrastructure*; D008666:Metalloendopeptidases / Q000494:pharmacology*; D051379:Mice; D011817:Rabbits
chemical_list: D008666:Metalloendopeptidases; C039814:hemagglutinin-protease