title: [Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: a rare preneoplastic condition].
abstract: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is an uncommon preneoplastic condition, often associated with typical carcinoid tumours. The observations reported below concern two women, both suffering from chronic pulmonary symptoms. These patients underwent computed tomography that showed a solitary nodule in the first patient and multiple sub centimetre nodules in the second. In both cases histological studies of the pulmonary biopsies revealed: a proliferation of neuroendocrine cells dispersed in the bronchial and bronchiolar epithelium, more specifically superficial to the basement membrane; some tumourlets; a typical carcinoid tumour was also found in the first patient's biopsy. The choice of treatment remains difficult, mainly because the existing studies are restricted to small numbers of patients or isolated cases, a consequence of the low prevalence of this disease. Considering its slow evolution, management by long-term clinical, endoscopic and radiologic surveillance may be considered. If a carcinoid tumour is present or appears during the surveillance, the standard treatment is still surgical resection.
authors.affiliation: Service de Pneumologie, Hôpital de la Croix Rousse, CHU de Lyon, France.
authors.forename: L
authors.initials: L
authors.lastname: Lebras
authors.forename: D
authors.initials: D
authors.lastname: Arpin
authors.forename: S
authors.initials: S
authors.lastname: Collardeau-Frachon
authors.forename: S
authors.initials: S
authors.lastname: Isaac
authors.forename: J-C
authors.initials: JC
authors.lastname: Guerin
authors.forename: M
authors.initials: M
authors.lastname: Perol
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis*; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis*; D009490:Neurosecretory Systems / Q000473:pathology*; D011230:Precancerous Conditions / Q000175:diagnosis*