title: [The intravitreal application of the tissue plasminogen activator in the treatment of submacular hemorrhage--a case report].
abstract: The authors present the possibility to influence therapeutically the submacular hemorrhage caused by age-related macular degeneration in the presence of choroidal neovascular membrane by means of recombinant plasminogen tissue activator (rt-PA) and expansive gas intravitreal injection followed by pneumatic relocation of the hemorrhage out of the foveolar region. The therapy is presented in a case report. The submacular hemorrhage without treatment causes serious decrease of visual functions. The human recombinant plasminogen tissue activator that is a glycoprotein, activating the transformation of plasminogen directly to plasmin has a trombolytic effect. Rt-PA is activated by binding to fibrin with high affinity. This minimally invasive procedure gives the possibility to treat this prognostic unfavorable finding, so after the lysis and pneumorelocation of the hemorrhage from the macular region we can treat the choroidal neovascular membrane.
authors.affiliation: Ocní klinika FN a UP Olomouc. evzen.fric@centrum.cz
authors.forename: E
authors.initials: E
authors.lastname: Fric
authors.forename: M
authors.initials: M
authors.lastname: Sín
authors.forename: M
authors.initials: M
authors.lastname: Rehák
authors.forename: O
authors.initials: O
authors.lastname: Chrapek
authors.forename: J
authors.initials: J
authors.lastname: Simicák
authors.forename: J
authors.initials: J
authors.lastname: Fehák
mesh_terms: D020256:Choroidal Neovascularization / Q000150:complications; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008268:Macular Degeneration / Q000150:complications*; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage; D012166:Retinal Hemorrhage / Q000188:drug therapy* / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*; D014822:Vitreous Body
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator