Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.
Exposure of male rats to permanent or natural illumination of North-Western Russia accelerated their death in comparison with animals exposed to standard (12 h) light. Permanent illumination promoted the development of spontaneous tumors in comparison with the standard photoregimen. Injection of epithalone (synthetic Ala-Glu-Asp-Gly peptide; subcutaneously 0.1 microg/rat 5 times a week from the age of 4 months until natural death) virtually did not change the mean lifespan of male rats, but was associated with a significant (p<0.05) normalization of population aging rate and hence, time of mortality rate doubling in groups exposed to natural or constant illumination. Epithalone injected to rats exposed to any photoregimen significantly inhibited the development of spontaneous tumors, primarily testicular leydigomas and leukemias.
Vinogradova
I A
IA
Petrozavodsk State University; N. N. Petrov Institute of Oncology, Rosmedtekhnologies, St. Petersburg, Russia.
Bukalev
A V
AV
Zabezhinski
M A
MA
Semenchenko
A V
AV
Khavinson
V Kh
VKh
Anisimov
V N
VN
D000375:Aging / Q000187:drug effects* / Q000528:radiation effects*; D000818:Animals; D017849:Animals, Inbred Strains; D008027:Light; D008029:Lighting / Q000379:methods; D008136:Longevity / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009369:Neoplasms / Q000473:pathology; D009842:Oligopeptides / Q000494:pharmacology*; D017440:Photoperiod; D010789:Phototherapy / Q000379:methods*; D011829:Radiation Dosage; D051381:Rats
D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine