Asymmetric reduction of ketimines with trichlorosilane employing an imidazole derived organocatalyst.
Organocatalysts for the asymmetric reduction of ketimines are presented that function well at low catalyst loadings providing chiral amines in good yield and enantioselectivity, the latter appearing to be independent of the ketimine substrate geometry.
Gautier
François-Moana
FM
Department of Chemistry, University of Sheffield, Dainton Building, Brook Hill, Sheffield, UKS3 7HF. simon.jones@sheffield.ac.uk.
Jones
Simon
S
Martin
Stephen J
SJ
D002384:Catalysis; D007093:Imidazoles / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D017646:Organosilicon Compounds / Q000737:chemistry; D010084:Oxidation-Reduction; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
D007093:Imidazoles; D007097:Imines; D017646:Organosilicon Compounds; D012821:Silanes; C065893:trichlorosilane