[Structure and function of the eukaryotic ribosome].
The protein biosynthesis is a complicated process and not fully understood yet. According to smaller size and less complicated structure, understanding of prokaryotic 70S ribosomes is much more advanced. Eucaryotic 80S ribosomes are more complex and generate more difficulties in research. The morphology of 80S ribosome has been pretty well resolved and we know a lot about mechanism of functioning. Determination of the interactions between the ribosomes and the factors taking part in protein biosynthesis is still a great challenge. Dynamic changes of these interactions during particular steps of elongation cycle are quite difficult to understand. Conformational changes of the ribosome are of great functional and regulatory importance during protein biosynthesis. They are essential for the whole gene expression process. Only further research of the structure and function of the ribosome will lead us to knowledge about specificity of the mechanism of their action. In this article we present current opinions concerning structure and function of the eukaryotic ribosomes.
Bakowska-Zywicka
Kamilla
K
Institute of Bioorganic Chemistry, Polish Academy of Sciences, 12/14 Noskowskiego St., 61-704 Poznan, Poland. bakowska@ibch.poznan.pl
Twardowski
Tomasz
T
D000818:Animals; D001419:Bacteria / Q000235:genetics; D005057:Eukaryotic Cells / Q000378:metabolism*; D007448:Invertebrates / Q000235:genetics; D008958:Models, Molecular; D010944:Plants / Q000235:genetics; D014176:Protein Biosynthesis / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000737:chemistry; D012343:RNA, Transfer / Q000737:chemistry; D011817:Rabbits; D051381:Rats; D012270:Ribosomes / Q000737:chemistry* / Q000502:physiology*; D014178:Translocation, Genetic / Q000502:physiology
D011506:Proteins; D012335:RNA, Ribosomal; D012343:RNA, Transfer