Regulatory T cells: the cunning fox and its clinical application.
So profound is the potential for regulatory T cells (Tregs) to control unwanted immune responses that in 2008 an entire conference was dedicated to them. The underlying concept of this conference, "China Tregs 2008," was that unraveling the cellular biology of Tregs will lead to important advances for therapies in virtually all human disease processes and in transplantation. The master-switch of immune regulation is the forkhead transcription factor Foxp3; in mice, Foxp3 is a sine qua non for regulatory activity. At "China Tregs 2008," the cell signaling events leading to the expression of Foxp3 and those events downstream were explored together with presentations on how the latest knowledge of the biology of Tregs is being translated in the clinic.
Game
David S
DS
Department of Renal Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Cao
Xuetao
X
Jiang
Shuiping
S
D000818:Animals; D051858:Forkhead Transcription Factors / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007167:Immunotherapy; D051379:Mice; D015398:Signal Transduction / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse