A novel approach to the CDE ring system of pectenotoxin-4 triggered by VO(acac)(2)-induced epoxy-acetalization.
A novel approach to the CDE fragment of pectenotoxin-4 is described wherein the bicyclic acetal is constructed via a cascade cyclization induced by VO(acac)(2) epoxidation of a homoallylic alcohol.
Carley
Sarah
S
Department of Chemistry, The University of Auckland, 23 Symonds Street, Auckland, New Zealand.
Brimble
Margaret A
MA
D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D008387:Marine Toxins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D000095702:Polyether Toxins
D018942:Macrolides; D008387:Marine Toxins; C471226:pectenotoxin-4; D000095702:Polyether Toxins