Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys.
Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4(+) and CD8(+) T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
Lozano Reina
José-Manuel
JM
Institut Pasteur, Régulation des Infections Rétrovirales, Paris, France.
Favre
David
D
Kasakow
Zeljka
Z
Mayau
Véronique
V
Nugeyre
Marie-Thérèse
MT
Ka
Thierno
T
Faye
Abdourahmane
A
Miller
Christopher J
CJ
Scott-Algara
Daniel
D
McCune
Joseph M
JM
Barré-Sinoussi
Françoise
F
Diop
Ousmane M
OM
Müller-Trutwin
Michaela C
MC
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001769:Blood / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D015683:Gene Products, gag / Q000276:immunology*; D015483:HIV Antibodies / Q000097:blood; D008198:Lymph Nodes / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag; D015483:HIV Antibodies