title: [A case of multiple lymph node metastases from transverse colon cancer successfully treated with oral tegafur/uracil (UFT)/Leucovorin (LV)].
abstract: Oral tegafur/uracil (UFT)/Leucovorin (LV) therapy has been used for chemotherapy for advanced colorectal cancer with anti-cancer effects the same as conventional 5-fluorouracil and Leucovorin (5-FU/LV). However, the effectiveness and safety of UFT/LV in the treatment of elderly patients with advanced colorectal cancer is not evaluated. We report a case of multiple lymph node metastases from colon cancer successfully treated with UFT/LV. An 81-year-old man had been admitted to our hospital because of left neck and axillary mass, which was diagnosed as transverse colon cancer with multiple lymph node metastases. After a laparoscopic partial resection of transverse colon, UFT/LV (UFT 300 mg/m2/day and LV 75 mg/day) was administered for 4-week-on and 1-week-off. After the administration of the chemotherapy, a good partial response of these metastatic lymph nodes was achieved. No grade 3 or more severe adverse reactions have been observed. He has now survived for 14 months without a recurrence after the administration of the chemotherapy. This case suggests the effectiveness and safety of UFT/LV in elderly patients with colorectal cancer.
authors.affiliation: Dept. of Surgery, Suita Municipal Hospital.
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Tomimaru
authors.forename: Yoshihito
authors.initials: Y
authors.lastname: Ide
authors.forename: Kohei
authors.initials: K
authors.lastname: Murata
mesh_terms: D000284:Administration, Oral; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D044684:Colon, Transverse; D003110:Colonic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D005641:Tegafur / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D005641:Tegafur; D002955:Leucovorin