title: Effect of acute postural variation on diabetic macular oedema.
abstract: OBJECTIVE
  This study aimed to study the pathophysiology of diabetic macular oedema (DMO) by analysis of concomitant changes in macular volume (MV), mean arterial blood pressure (MABP), intraocular pressure (IOP), and retinal artery and vein diameters in response to acute postural changes in patients with DMO and healthy subjects.
  
  
  METHODS
  Thirteen patients with DMO (13 eyes) and five healthy subjects (five eyes) were examined after resting in a chair for 15 mins using optical coherence tomography to measure MV and fundus photography to assess retinal vessel diameters. The patients then lay down for 60 mins, during which they were examined repeatedly before they were reseated and examined again. Intraocular pressure was measured using pulse-air tonometry, arterial blood pressure by sphygomanometry and fluid columns using rulers and a spirit level.
  
  
  RESULTS
  In healthy subjects, retinal artery (p = 0.02) and vein (p = 0.001) diameters decreased when subjects lay down, whereas MV remained stable. In patients with DMO, no orthostatic variation in retinal vessel diameters could be demonstrated, whereas MV had increased by 2.4 +/- 0.6% (mean +/- standard error of the mean; p = 0.006) 50 mins after assuming a recumbent position. In both healthy subjects and DMO patients, MABP decreased and IOP increased in a recumbent position, with no significant difference between the groups.
  
  
  CONCLUSIONS
  The increase in MV that occurs in DMO when changing from a seated to a recumbent position is associated with a failure of retinal artery contraction, a response seen in healthy subjects that appears to counter-regulate the increase in ocular perfusion pressure caused by assuming a recumbent position.
authors.affiliation: Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. vinten@oftalmolognet.dk
authors.forename: Martin
authors.initials: M
authors.lastname: Vinten
authors.forename: Morten
authors.initials: M
authors.lastname: la Cour
authors.forename: Henrik
authors.initials: H
authors.lastname: Lund-Andersen
authors.forename: Michael
authors.initials: M
authors.lastname: Larsen
mesh_terms: D001794:Blood Pressure / Q000502:physiology; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008269:Macular Edema / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011187:Posture / Q000502:physiology*; D012171:Retinal Vessels / Q000473:pathology; D019722:Sphygmomanometers; D041623:Tomography, Optical Coherence; D014065:Tonometry, Ocular