Regional electroencephalogram (EEG) spectral power and hemispheric coherence in young adults born at extremely low birth weight.
OBJECTIVE
We examined the effects of extremely low birth weight (ELBW<1000 g) on adult brain functioning.


METHODS
We measured baseline regional EEG spectral power and hemispheric coherence in a cohort of 154 (M age=23 years) non-impaired young adults who were born at ELBW (n=71; M birth weight=874 g, M gestation age=27.5 weeks) and in a control group of full-term adults born at normal birth weight (NBW; n=83).


RESULTS
ELBW adults exhibited significantly more power in the low EEG frequency bands (delta and theta) and less in the high EEG frequency bands (alpha and beta) than the NBW adults. This relative difference in the amount of high to low-frequency power was especially salient in the frontal regions. ELBW adults also exhibited significantly more short-distance EEG coherence in the right hemisphere compared to the NBW adults.


CONCLUSIONS
Our results suggest that even among ELBW survivors without impairments, adverse events early in life may result in subtle neurological abnormalities.


CONCLUSIONS
This study provides a unique EEG profile of young adult survivors of ELBW showing that maturational delays of the brain may persist into late adolescence and emerging adulthood.
Miskovic
Vladimir
V
McMaster Institute for Neuroscience Discovery and Study, McMaster University, Hamilton, Ont., Canada L8S 4K1.
Schmidt
Louis A
LA
Boyle
Michael
M
Saigal
Saroj
S
D000328:Adult; D000704:Analysis of Variance; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D015331:Cohort Studies; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D052577:Infant, Extremely Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D008297:Male; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000379:methods; D055815:Young Adult