Splenic rupture, secondary to G-CSF use for chemotherapy induced neutropenia: a case report and review of literature.
BACKGROUND
Chemotherapy Induced neutropenia is a frequent and serious complication of cytotoxic cancer treatment.Granulocyte colony stimulating factors (G-CSF) are frequently used to counter neutropenia, attempt rapid recovery of patients and allow for continuation of treatment without compromise on dose, especially in curative malignancies. Generally regarded as safe, G-CSF use has been very rarely reported to have resulted in serious side effects, such as, splenic rupture.


METHODS
We are reporting a case of a twenty years old man, who was being treated for T cell acute lymphoblastic leukemia and received colony stimulating factors for treatment of severe neutropenia and suffered from splenic rupture, He was treated with splenectomy.


CONCLUSIONS
Although extremely rare, splenic rupture can be a serious and sometimes life threatening complication of high dose colony stimulating factors therapy.
Masood
Nehal
N
Section of Oncology, Department of Medicine, the Aga Khan University Hospital, Karachi, Pakistan. asim.jshaikh@aku.edu.
Shaikh
Asim Jamal
AJ
Memon
Wasim Ahmed
WA
Idress
Romana
R