[Avandia and avandamet in the treatment of patients with diabetes mellitus type 2: effects on secretion of some fat tissue hormones].
OBJECTIVE
To study effects of avandia and its combination with metformine (avandamet) on secretion of fat tissue hormones.


METHODS
The examination protocol for 42 patients with type 2 diabetes mellitus (DM) aged 62.4 +/- 7.7 years comprised tests for blood levels of leptin, soluble receptor to leptin, insulin, grelin, resistin and adiponectine.


RESULTS
The treatment resulted in reduction of fasting glycemia from 10.69 +/- 2.54 to 8.42 +/- 1.73 mmol/l, of glycosilated hemoglobin--from 8.1 + 1.6 to 7.75%, immunoreactive insulin--from 19.1 +/- 8.3 to 12.0 +/- 6.5 mg/ml, grelin--from 21.7 +/- 14.6 to 17.3 +/- 13.7 mg/ml, leptin--from 40.3 +/- 24.2 to 26.9 +/- 15.4 mg/ml, soluble receptor to leptin--from 17.9 +/- 4.5 to 13.1 +/- 3.5 mg/ml. LDLP and HDLP cholesterol was high.


CONCLUSIONS
Avandia and avandamet are effective antidiabetic drugs with a beneficial effect on secretion of fat tissue hormones.
Balabolkin
M I
MI
Mamaeva
G G
GG
Klebanova
E M
EM
Kuzin
A G
AG
Tel'nova
M E
ME
Kreminskaia
V M
VM
D052242:Adiponectin / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism*; D004338:Drug Combinations; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D054439:Ghrelin / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D008297:Male; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D052243:Resistin / Q000378:metabolism*; D000077154:Rosiglitazone; D013844:Thiazoles / Q000627:therapeutic use*; D045162:Thiazolidinediones / Q000627:therapeutic use*
D052242:Adiponectin; D004338:Drug Combinations; D005343:Fibrinolytic Agents; D054439:Ghrelin; D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin; D052243:Resistin; D013844:Thiazoles; D045162:Thiazolidinediones; C471074:rosiglitazone-metformin combination; D000077154:Rosiglitazone; D008687:Metformin