Inhibition of peroxidase-catalyzed iodination by cephalosporins: Metallo-beta-lactamase-induced antithyroid activity of antibiotics.
Broad-spectrum antibiotics with heterocyclic side chains strongly inhibit peroxidase-catalyzed iodination in the presence of metallo-beta-lactamase. This suggests that antibiotic resistance due to hydrolysis of the beta-lactam ring in antibiotics would have negative effects on thyroid activity.
Tamilselvi
A
A
Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore, India.
Mugesh
Govindasamy
G
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D055162:Biocatalysis; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006868:Hydrolysis; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D010544:Peroxidases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D004791:Enzyme Inhibitors; D007455:Iodine; D010544:Peroxidases; D001618:beta-Lactamases