The liver--a potential new player in islet regeneration?
Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expansion of islet mass and enhanced insulin secretion.
Moss
Larry G
LG
Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27704, USA.
Newgard
Christopher B
CB
D002490:Central Nervous System / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007515:Islets of Langerhans / Q000502:physiology*; D008099:Liver / Q000201:enzymology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction
D019950:Mitogen-Activated Protein Kinase 1