Clinical significance of Gata-1, Gata-2, EKLF, and c-MPL expression in acute myeloid leukemia.
The aim of this study was to evaluate the biological correlation and prognostic impact of Gata-1, Gata-2, EKLF, and c-MPL transcript level in a group of 41 acute myeloid leukemia (AML) patients. Gata-1 overexpression was related to advanced age and a low percentage of bone marrow blasts and was associated with the expression of CD34 antigen and lymphoid T markers. The negative impact of Gata-1 expression on the probability of achieving complete remission has been confirmed. Gata-2 overexpression was associated with a low percentage of blasts in BM and males. Expression of c-MPL was associated with CD34+ AML and M2 FAB AML subtype. A higher expression of EKLF was found in secondary AML versus primary AML. Nevertheless, patients expressing EKLF had a longer overall survival and event free survival than those patients that did not express EKLF. Our study has identified expression of EKLF as a factor with a favorable impact on prognosis in AML.
Ayala
Rosa M
RM
Servicio de Hematologia, Hospital Universitario 12 de Octubre, Madrid, España. rayaladiaz@yahoo.es
Martínez-López
Joaquín
J
Albízua
Enriqueta
E
Diez
Amalia
A
Gilsanz
Florinda
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D018572:Disease-Free Survival; D004920:Erythropoiesis / Q000235:genetics; D050982:GATA1 Transcription Factor / Q000032:analysis / Q000502:physiology*; D050989:GATA2 Transcription Factor / Q000032:analysis / Q000502:physiology*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000032:analysis / Q000502:physiology*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis / Q000502:physiology*; D016609:Neoplasms, Second Primary / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D053628:Receptors, Thrombopoietin / Q000032:analysis / Q000502:physiology*; D016019:Survival Analysis; D055815:Young Adult
D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human; D050989:GATA2 Transcription Factor; C494711:GATA2 protein, human; D051741:Kruppel-Like Transcription Factors; D009363:Neoplasm Proteins; D053628:Receptors, Thrombopoietin; C080774:erythroid Kruppel-like factor; C082218:MPL protein, human