title: Genetics of atrial fibrillation.
abstract: Recent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.
authors.affiliation: Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Steven A
authors.initials: SA
authors.lastname: Lubitz
authors.forename: B Alexander
authors.initials: BA
authors.lastname: Yi
authors.forename: Patrick T
authors.initials: PT
authors.lastname: Ellinor
mesh_terms: D001281:Atrial Fibrillation / Q000235:genetics*; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007473:Ion Channels / Q000235:genetics; D009154:Mutation
chemical_list: D007473:Ion Channels; D004247:DNA