title: Synthesis of imidazol-1-yl-acetic acid hydrochloride: a key intermediate for zoledronic acid.
abstract: A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.
authors.affiliation: New Drug Discovery, Matrix Laboratories Limited, Anrich Industrial Estate, Bollaram, Jinnaram Mandal, Medak District, Andhra Pradesh, India-502 325. sksingh_p2@rediffmail.com
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Singh
authors.forename: Narendra
authors.initials: N
authors.lastname: Manne
authors.forename: Purna Chandra
authors.initials: PC
authors.lastname: Ray
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal