title: Spin-echo MRI using pi/2 and pi hyperbolic secant pulses.
abstract: Frequency-modulated (FM) pulses have practical advantages for spin-echo experiments, such as the ability to produce a broadband pi rotation, with an inhomogeneous radiofrequency (RF) field. However, such use leads to a nonlinear phase of the transverse magnetization, which is why FM pulses like the hyperbolic secant (HS) pulse are not commonly used for multislice spin-echo magnetic resonance imaging (MRI). Here, a general theory and methods are described for conventional spin-echo imaging using a pi HS pulse for refocusing. Phase profiles produced by the HS pulse are analytically described. The analysis is extended to yield the specific relationships between pulse parameters and gradients, which must be satisfied to compensate the nonlinear phase variation produced with a spin-echo sequence composed of pi/2 and pi HS pulses (the pi/2 HS - pi HS sequence). The latter offers advantages for multislice spin-echo MRI, including excellent slice-selection and partial compensation for RF inhomogeneity. Furthermore, it can be implemented with a shorter echo time and lower power deposition than a previously described method using a pair of pi HS pulses.
authors.affiliation: The Center for Magnetic Resonance Research and Department of Radiology, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA. jypark@cmrr.umn.edu
authors.forename: Jang-Yeon
authors.initials: JY
authors.lastname: Park
authors.forename: Michael
authors.initials: M
authors.lastname: Garwood
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels