title: Anaplasma marginale Yucatan (Mexico) Strain. Assessment of low virulence and potential use as a live vaccine.
abstract: Anaplasma marginale Yucatan strain was found to have low virulence in cattle. We studied the virulence of this isolate by experimental inoculation of 113 susceptible cattle at increasing doses, after which only one animal required treatment for clinical disease. Subsequently, 104 cattle received a live vaccine of this strain by inoculation, which induced immunoprotection after heterologous challenged exposure with a different A. marginale isolate. In this study 14% of the immunized cattle required treatment as compared with the control nonimmunized cattle, in which 56% required treatment. The A. marginale vaccine strains used for the immunization studies had MSP1a variable regions that were different from those used for the challenge exposure.
authors.affiliation: Centro de Investigaciones Disciplinarias, en Parasitología Veterinaria, Instituto Nacional de Investigaciones Forestales, Agrícolas y Pecuarias, Secretaría de Agricultura, Ganadería, Desarrollo Rural, Pesca y Alimentació, Jiutepec, Morelos, Méxcio.
authors.forename: Sergio D
authors.initials: SD
authors.lastname: Rodríguez Camarillo
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: García Ortiz
authors.forename: Edmundo E
authors.initials: EE
authors.lastname: Rojas Ramírez
authors.forename: Germinal J
authors.initials: GJ
authors.lastname: Cantó Alarcón
authors.forename: Jesús F
authors.initials: JF
authors.lastname: Preciado de la Torre
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Rosario Cruz
authors.forename: Juan A
authors.initials: JA
authors.lastname: Ramos Aragón
authors.forename: Ramón
authors.initials: R
authors.lastname: Aboytes Torres
mesh_terms: D042322:Anaplasma marginale / Q000276:immunology* / Q000472:pathogenicity*; D000712:Anaplasmosis / Q000517:prevention & control*; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D002417:Cattle; D004797:Enzyme-Linked Immunosorbent Assay; D016133:Polymerase Chain Reaction; D014774:Virulence
chemical_list: D001428:Bacterial Vaccines