New strategy for targeting of photosensitizers. Synthesis of glycodendrimeric phenylporphyrins, incorporation into a liposome membrane and interaction with a specific lectin.
Two glycodendrimeric phenylporphyrins were synthesized and their interaction with phospholipids was studied at the air-water interface and in liposome bilayers; such liposomes bearing glycodendrimeric porphyrin could constitute an efficient carrier for drug targeting in photodynamic therapy.
Ballut
Séverine
S
UMR 176 CNRS/Institut Curie, Institut Curie, Bât 110, Univ. Paris-Sud, F-91405, Orsay, France.
Makky
Ali
A
Loock
Bernard
B
Michel
Jean-Philippe
JP
Maillard
Philippe
P
Rosilio
Véronique
V
D050091:Dendrimers / Q000138:chemical synthesis*; D016503:Drug Delivery Systems; D006031:Glycosylation; D037102:Lectins / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008956:Models, Chemical; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis*; D011166:Porphyrins / Q000138:chemical synthesis*
D050091:Dendrimers; D037102:Lectins; D008081:Liposomes; D017319:Photosensitizing Agents; D011166:Porphyrins