[Influence of sperm DNA damage on reproductive outcomes and its clinical significance].
Many factors are responsible for sperm DNA damage, which may lead to fertilization failure and embryo maldevelopment. At present, sperm DNA damage can be detected by more and more methods, which are considered to be superior to the conventional measures. There are some clinical indications for tests of sperm DNA damage in IVF/ICSI, but additional studies are still needed to fully define the clinical value of testing sperm DNA damage.
Wang
Xiao-Meng
XM
Department of Cell Biology/Jilin Provincial Research Center of Reproductive Medicine, Bethune Medical College, Jilin University, Jilin, Changchun 130021, China.
Liu
Rui-Zhi
RZ
D004249:DNA Damage; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000166:cytology*