title: [Vitamin D receptor gene polymorphisms: no association with low bone mineral density in adolescent idiopathic scoliosis girls].
abstract: OBJECTIVE
  To investigate the association of vitamin D receptor (VDR) gene polymorphisms with low bone mineral density (BMD) in adolescent idiopathic scoliosis (AIS) girls.
  
  
  METHODS
  Blood samples were obtained from 146 AIS girls and 146 healthy girls. Anthropometric parameters of AIS group including age, body height, weight and Cobb angle were all recorded. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect and analyze VDR gene distributions of AIS group and control group. BMD of the lumbar spine (L(1)-L(4)) and proximal femur were measured using dual energy x-ray absorptiometry in AIS group.
  
  
  RESULTS
  The frequency of Bb genotype was significantly higher in patients than that in controls (P < 0.05). There was no distinction among the lumbar spine and proximal femur BMD of each genotype in AIS group (P > 0.05).
  
  
  CONCLUSIONS
  VDR gene polymorphisms have no association with the low spine lumbar and proximal femur BMD in AIS girls.
authors.affiliation: Department of Spinal Surgery, the Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing 210008, China.
authors.forename: Wen-jun
authors.initials: WJ
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiu
authors.forename: Feng
authors.initials: F
authors.lastname: Zhu
authors.forename: Ze-zhang
authors.initials: ZZ
authors.lastname: Zhu
authors.forename: Xu
authors.initials: X
authors.lastname: Sun
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Zhi-jun
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D015519:Bone Density / Q000235:genetics*; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012600:Scoliosis / Q000235:genetics / Q000503:physiopathology*
chemical_list: D018167:Receptors, Calcitriol