title: A longitudinal study of tremor frequencies in Parkinson's disease and essential tremor.
abstract: OBJECTIVE
  There is evidence that the tremor frequency in essential tremor (ET) decreases with time. Longitudinal studies on the evolution of tremor frequencies in Parkinson's disease (PD) have so far not been published. Here, we present a longitudinal analysis of tremor frequencies in PD and ET.
  
  
  METHODS
  We analyzed the standardized accelerometric and electromyographic tremor recordings of 53 patients with PD and 38 patients with ET who underwent repeated routine tremor recordings between 1991 and 2002.
  
  
  RESULTS
  In an average follow-up period of 44.9 months in PD and 50.6 months in ET, the average number of tremor recordings was 3.3 in PD and 3.7 in ET. In both disorders, tremor frequencies tended to decrease with time. The average annual decrease of the tremor frequency was 0.09 Hz/year in Parkinsonian rest tremor, 0.08 Hz/year in Parkinsonian postural tremor and 0.12 Hz/year in ET.
  
  
  CONCLUSIONS
  The tremor frequency decreases with time in both PD and ET. The similarity of this decrease in PD and ET may point to a common underlying pathophysiological mechanism.
  
  
  CONCLUSIONS
  Decreasing tremor frequencies with time may be functionally important by inducing larger tremor amplitudes due to the low-pass filtering properties of muscles and limbs.
authors.affiliation: Neurologische Universitätsklinik, Neurozentrum, Breisacher Strasse 64, 79106 Freiburg, Germany. hellwig@npi-freiburg.de
authors.forename: B
authors.initials: B
authors.lastname: Hellwig
authors.forename: P
authors.initials: P
authors.lastname: Mund
authors.forename: B
authors.initials: B
authors.lastname: Schelter
authors.forename: B
authors.initials: B
authors.lastname: Guschlbauer
authors.forename: J
authors.initials: J
authors.lastname: Timmer
authors.forename: C H
authors.initials: CH
authors.lastname: Lücking
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D004576:Electromyography / Q000379:methods; D020329:Essential Tremor / Q000150:complications*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications*; D013997:Time Factors; D014202:Tremor / Q000209:etiology*