title: [Treatment with pegylated interferon and ribavirin in a patient with fibrosing cholestatic hepatitis due to recurrent hepatitis C after liver transplantation].
abstract: Fibrosing cholestatic hepatitis (FCH) is the most devastating manifestation of recurrent hepatitis C in transplant recipients with hepatitis C virus (HCV), possibly leading to death or retransplantation. Although FCH was first described as a complication of hepatitis B, this manifestation has been well documented in association with HCV in the setting of liver transplantation, bone marrow transplantation, heart transplantation, and end-stage human immunodeficiency virus infection. We report the clinical course and antiviral response in a patient with FCH due to recurrent hepatitis C after cadaveric liver transplantation who was treated with pegylated interferon alpha-2a and ribavirin.
authors.affiliation: Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea.
authors.forename: Byung Kook
authors.initials: BK
authors.lastname: Kim
authors.forename: So Young
authors.initials: SY
authors.lastname: Kwon
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Ko
authors.forename: Won Hyeok
authors.initials: WH
authors.lastname: Choe
authors.forename: Chang Hong
authors.initials: CH
authors.lastname: Lee
authors.forename: He Seong
authors.initials: HS
authors.lastname: Han
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Chang
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D002780:Cholestasis, Intrahepatic / Q000175:diagnosis* / Q000473:pathology; D003131:Combined Modality Therapy; D016174:Hepacivirus / Q000187:drug effects; D019698:Hepatitis C, Chronic / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012367:RNA, Viral / Q000032:analysis; D011994:Recombinant Proteins; D012008:Recurrence; D012254:Ribavirin / Q000008:administration & dosage*; D014057:Tomography, X-Ray Computed
chemical_list: D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; C100416:peginterferon alfa-2a