The quality of life of children and adolescents with X-linked agammaglobulinemia.
BACKGROUND
The health-related quality of life in X-linked agammaglobulinemia was investigated in 25 children and adolescents patients through the Italian version of Pediatric Quality of Life Inventory 4.0 Generic Core Scale for patients aged less then 18 years, comparing child perception to that of the parents and the physician's evaluation. The data were compared with the ones of 80 healthy controls and the literature data of a group of patients with rheumatic diseases.


CONCLUSIONS
The agammaglobulinemia subjects perceived a lower global quality of life than the healthy subjects, but significantly higher than the rheumatic diseases controls. The clinical relevance of health-related quality of life assessment in X-linked agammaglobulinemia pediatric patients is discussed.
Soresina
Annarosa
A
Dipartimento di Pediatría, Università degli Studi di Brescia, 25123 Brescia, Italy. soresina@med.unibs.it
Nacinovich
Renata
R
Bomba
Monica
M
Cassani
Morena
M
Molinaro
Anna
A
Sciotto
Antonella
A
Martino
Silvana
S
Cardinale
Fabio
F
De Mattia
Domenico
D
Putti
Caterina
C
Dellepiane
Rosa Maria
RM
Felici
Leonardo
L
Parrinello
Giovanni
G
Neri
Francesca
F
Plebani
Alessandro
A
D000203:Activities of Daily Living; D000293:Adolescent; D000361:Agammaglobulinemia / Q000188:drug therapy / Q000235:genetics / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D040181:Genetic Diseases, X-Linked / Q000188:drug therapy / Q000235:genetics / Q000523:psychology*; D006304:Health Status; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009154:Mutation / Q000235:genetics; D010290:Parents; D011788:Quality of Life; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires
D016756:Immunoglobulins, Intravenous