title: Unusual clinical presentations of giant prolactinomas.
abstract: Giant prolactinomas are rare pituitary tumors which have scarcely been reported in the literature. We describe three men with unusual presenting features of prolactin-secreting giant pituitary adenomas: prolonged and increasingly disturbing intolerance to light and noise; strange behavior and mood disturbances; and rhinorrhea followed by a finding of cerebrospinal fluid leakage. Treatment with dopamine agonist alleviated all symptoms, with concomitant suppression of plasma prolactin levels and a significant reduction in tumor mass. These cases emphasize the importance of considering unusual symptoms in the differential diagnosis of giant prolactinomas and the effectiveness of medical treatment.
authors.affiliation: Institute of Endocrinology & Metabolism, Rabin Medical Center, Beilinson Hospital, Petah Tiqwa, Israel.
authors.forename: Simona
authors.initials: S
authors.lastname: Grozinsky-Glasberg
authors.forename: Ilan
authors.initials: I
authors.lastname: Shimon
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000473:pathology; D015175:Prolactinoma / Q000175:diagnosis* / Q000473:pathology; D047368:Tumor Burden