Adiponectin and type 2 diabetes in Samoan adults.
OBJECTIVE
Previous studies have established an association between adiponectin and type 2 diabetes. It is unclear whether adiponectin will be useful among Samoan Islanders, characterized by markedly elevated levels of obesity, in differentiating those at risk of developing type 2 diabetes.


METHODS
Cross-sectional, genetic epidemiology study of obesity in American Samoa and Samoa 2002-2003 (n = 1,599). Logistic regression provided adjusted odds ratios and 95% confidence intervals for the association between adiponectin, diabetes, and prediabetes (impaired fasting glucose).


RESULTS
There is a significant decreasing trend in the odds of diabetes and prediabetes across increasing quintiles of adiponectin with an OR of 2.8 (95% CI: 1.6, 5.0) and 2.9 (95% CI: 1.5, 5.7), respectively, in the lowest relative to the highest quintile of adiponectin (P-for-trend = 0.004 and 0.001).


CONCLUSIONS
Adiponectin is an important correlate, independent of other risk factors, of the pathogenesis of type 2 diabetes among Samoan islanders and may help distinguish those at higher risk of developing this disease.
Dibello
Julia R
JR
Department of Community Health, International Health Institute, Brown University, Providence, RI 02912, USA.
Baylin
Ana
A
Viali
Satupaitea
S
Tuitele
John
J
Bausserman
Linda
L
McGarvey
Stephen T
ST
D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D000328:Adult; D018948:American Samoa; D001786:Blood Glucose / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D014905:Independent State of Samoa; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D016017:Odds Ratio; D012307:Risk Factors; D055815:Young Adult
C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose