title: Antileprosy activity and preliminary toxicological characteristics of some dialkyldithiocarbamate derivatives.
abstract: Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment.
authors.affiliation: Institute of Leprosy Research, Federal Agency for Health Care and Social Development Health, Astrakhan, Russia. niil@astmail.astranet.ru
authors.forename: N G
authors.initials: NG
authors.lastname: Urlyapova
authors.forename: A A
authors.initials: AA
authors.lastname: Yuschenko
authors.forename: A D
authors.initials: AD
authors.lastname: Daudova
authors.forename: V A
authors.initials: VA
authors.lastname: Makarov
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007917:Leprostatic Agents / Q000097:blood / Q000627:therapeutic use*; D007918:Leprosy / Q000097:blood / Q000188:drug therapy* / Q000401:mortality / Q000662:veterinary; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D050296:Microbial Viability / Q000187:drug effects; D009166:Mycobacterium leprae / Q000187:drug effects / Q000502:physiology; D013859:Thiocarbamates / Q000097:blood / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D007917:Leprostatic Agents; D013859:Thiocarbamates