P16 expression in odontogenic tumors.
OBJECTIVE
The aim of the study was to examine the immunohistochemical expression of a cell-cycle-related factor (p16) in order to elucidate its role in the growth and diffusion of odontogenic tumors.


METHODS
Thirty-six odontogenic tumors were divided into two groups according to their clinical behavior: group A and group B composed of tumors at low and high risk of recurrences, respectively. The ANOVA test was used to detect differences between the two groups.


RESULTS
p16 was expressed in both groups, but with different localization. A statistically significant difference was found in p16 expression of peripheral cells, with an increase in the expression in group B compared to group A (P < 0.05). In addition, there was no significant difference in p16 positive expression of the central cells of odontogenic tumors, which was high in both groups.


CONCLUSIONS
The present data show a correlation between p16 expression and the biological behavior of odontogenic tumors.
Artese
Luciano
L
Dental School, University of Chieti-Pescara, Chieti, Italy.
Piattelli
Adriano
A
Rubini
Corrado
C
Goteri
Gala
G
Perrotti
Vittoria
V
Iezzi
Giovanna
G
Piccirilli
Marcello
M
Carinci
Francesco
F
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000473:pathology; D009808:Odontogenic Tumors / Q000737:chemistry* / Q000473:pathology*; D018570:Risk Assessment
D014408:Biomarkers, Tumor; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins