title: Do tumor cavitation and sex in resected stage I non-small-cell lung cancer correlate with prognosis?
abstract: BACKGROUND
  Multiple factors have been reported as affecting the prognosis, and they affect the therapeutic outcomes of stage I non-small-cell lung cancer (NSCLC) patients. Most studies focus on patients receiving combined-modality therapy, whereas there are few studies that focus on patients undergoing surgery alone. The aim of this study was to identify risk factors for disease relapse and unfavorable prognosis in stage I NSCLC patients treated with surgery alone.
  
  
  METHODS
  A total of 315 stage I NSCLC patients who were treated with surgery alone as the definitive therapy were identified. Risk factors for disease relapse and unfavorable prognosis were estimated by univariate and multivariate analyses.
  
  
  RESULTS
  Sex, tumor pathologic stage, and cavitating lung cancer were identified as independent risk factors for relapse and overall survival using the multivariate analysis. Sex, tumor pathologic stage, and cavitating lung cancer were identified as independent risk factors for early relapse, and sex and cavitating lung cancer were independent risk factors for late relapse.
  
  
  CONCLUSIONS
  Tumor cavitation, pathologic stage IB, and being male are predictors of poor outcome for patients with stage I NSCLC who undergo resection.
authors.affiliation: Department of Lung Cancer, Cancer Institute & Hospital, Tian Jin Medical University, Tian Jin 300060, People's Republic of China.
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Yi
authors.initials: Y
authors.lastname: Pan
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Su
authors.forename: Jian
authors.initials: J
authors.lastname: You
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Zhao
authors.forename: Chang-Li
authors.initials: CL
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012737:Sex Factors