The role of leukocyte biology in laminitis.
The underlying pathogenesis of laminitis clearly depends importantly on inflammatory processes that recruit leukocytes at an early stage in disease. The role of leukocytes in the initiation of laminitis, or as an intermediary factor is currently being investigated using a limited array of models, and future studies require both new reagent and model systems if we are to clearly define how leukocytes propagate this disease. The opportunities presented by this type of research could easily include new and powerful treatment and preventative modalities.
Lunn
D Paul
DP
Department of Clinical Sciences, College of Veterinary Medicine, Colorado State University, Fort Collins, CO 80523, USA. lunnp@colostate.edu
Hurley
David J
DJ
D000818:Animals; D005534:Foot Diseases / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D006724:Hoof and Claw; D006734:Horse Diseases / Q000276:immunology* / Q000473:pathology; D006736:Horses; D007249:Inflammation / Q000276:immunology / Q000473:pathology / Q000662:veterinary; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology