New genetic abnormalities and treatment response in acute lymphoblastic leukemia.
Numerous genetic abnormalities have been identified in acute lymphoblastic leukemia (ALL). Here we review the recurrent abnormalities with emphasis on those recently discovered, and discuss their association with chemotherapy resistance or sensitivity and with clinical response to therapy. Also, the role of genetic abnormalities in leukemogenesis and their potential as therapeutic targets will be discussed.
Meijerink
Jules P P
JP
Department of Pediatric Oncology/Hematology, Erasmus Medical Center Rotterdam-Sophia Children's Hospital, Rotterdam, The Netherlands.
den Boer
Monique L
ML
Pieters
Rob
R
D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D009154:Mutation; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics
D014157:Transcription Factors