Screening of natural phenolic compounds for potential to inhibit bacterial cell division protein FtsZ.
FtsZ plays an important role in bacterial cell division by polymerizing to form the Z ring at the site of cytokinesis. Phytochemicals are known to disrupt bacterial cell division through inhibition of FtsZ assembly. In the present study phytochemicals like eugenol, trans-cinnamic acid, 4-formyl cinnamic acid, naringenin and caffeic acid were were tested for their potential to inhibit cell division. Effect of these antimicrobial compounds on the growth of E. coli was determined and the inhibition of FtsZ assembly in vitro was investigated. The present study revealed trans-cinnamic acid as the most potent inhibitor of FtsZ assembly.
Rastogi
Neerja
N
Department of Biochemistry, The Institute of Science, 15 Madame Cama Road, Mumbai 400 032, India.
Domadia
Prerna
P
Shetty
Sangeeta
S
Dasgupta
Debjani
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000378:metabolism*; D002109:Caffeic Acids / Q000737:chemistry; D002455:Cell Division; D002934:Cinnamates / Q000737:chemistry; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D004926:Escherichia coli / Q000378:metabolism*; D005054:Eugenol / Q000737:chemistry / Q000494:pharmacology; D044950:Flavanones / Q000737:chemistry / Q000494:pharmacology; D008027:Light; D008954:Models, Biological; D009391:Nephelometry and Turbidimetry; D011108:Polymers / Q000737:chemistry; D011994:Recombinant Proteins / Q000737:chemistry; D012542:Scattering, Radiation
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002109:Caffeic Acids; D002934:Cinnamates; D003598:Cytoskeletal Proteins; D044950:Flavanones; C071525:FtsZ protein, Bacteria; D011108:Polymers; D011994:Recombinant Proteins; C029010:cinnamic acid; D005054:Eugenol; C005273:naringenin; C040048:caffeic acid