title: Principles and application of an in vivo swine assay for the determination of arsenic bioavailability in contaminated matrices.
abstract: The assessment of arsenic (As) bioavailability from contaminated matrices is a crucial parameter for reducing the uncertainty when estimating exposure for human health risk assessment. In vivo assessment of As utilising swine is considered an appropriate model for human health risk assessment applications as swine are remarkably similar to humans in terms of physiology and As metabolism. While limited in vivo As bioavailability data is available in the literature, few details have been provided regarding technical considerations for performing in vivo assays. This paper describes, with examples, surgical, experimental design and analytical issues associated with performing chronic and acute in vivo swine assays to determine As bioavailability in contaminated soil and food.
authors.affiliation: Institute for Medical and Veterinary Science, Adelaide, SA, Australia. matthew.rees@imvs.sa.gov.au
authors.forename: Matthew
authors.initials: M
authors.lastname: Rees
authors.forename: Lloyd
authors.initials: L
authors.lastname: Sansom
authors.forename: Allan
authors.initials: A
authors.lastname: Rofe
authors.forename: Albert L
authors.initials: AL
authors.lastname: Juhasz
authors.forename: Euan
authors.initials: E
authors.lastname: Smith
authors.forename: John
authors.initials: J
authors.lastname: Weber
authors.forename: Ravi
authors.initials: R
authors.lastname: Naidu
authors.forename: Tim
authors.initials: T
authors.lastname: Kuchel
mesh_terms: D000818:Animals; D001151:Arsenic / Q000493:pharmacokinetics*; D001682:Biological Availability; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D005506:Food Contamination; D006801:Humans; D023421:Models, Animal; D018570:Risk Assessment / Q000379:methods; D012989:Soil Pollutants / Q000493:pharmacokinetics*; D013045:Species Specificity; D013552:Swine
chemical_list: D012989:Soil Pollutants; D001151:Arsenic