title: A case of acute hepatitis with Mycoplasma pneumoniae infection and transient depression of multiple coagulation factors.
abstract: We report a case of acute severe hepatitis with Mycoplasma pneumoniae (M. pneumoniae) infection and transient depression of multiple coagulation factors. A 5-year-old boy, previously healthy, was admitted with pneumonia. M. pneumoniae infection was confirmed by serology testing. Liver enzymes were elevated on admission without any past medical history. After treatment with azithromycin for 3 days, pneumonia improved, but the hepatitis was acutely aggravated. Partial thromboplastin time (PTT) was prolonged and depression of multiple coagulation factors developed. Liver biopsy revealed features consistent with acute hepatitis. A week later, liver enzymes were nearly normalized spontaneously. Normalization of prolonged PTT and coagulation factors were also observed several months later. This may be the first case of transient depression of multiple coagulation factors associated with M. pneumoniae infection.
authors.affiliation: Department of Pediatrics, Inha University College of Medicine, 7-206, 3-ga, Sinheung-dong, Jung-gu, Incheon 400-711, Korea.
authors.forename: Joo Hee
authors.initials: JH
authors.lastname: Chang
authors.forename: Young Se
authors.initials: YS
authors.lastname: Kwon
authors.forename: Bok Ki
authors.initials: BK
authors.lastname: Kim
authors.forename: Byong Kwan
authors.initials: BK
authors.lastname: Son
authors.forename: Jee Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Lim
authors.forename: Soon Ki
authors.initials: SK
authors.lastname: Kim
authors.forename: Joon Mi
authors.initials: JM
authors.lastname: Kim
authors.forename: Sung Kil
authors.initials: SK
authors.lastname: Kang
mesh_terms: D000208:Acute Disease; D001779:Blood Coagulation Factors / Q000378:metabolism; D002675:Child, Preschool; D006506:Hepatitis A / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D009177:Mycoplasma pneumoniae / Q000472:pathogenicity; D010314:Partial Thromboplastin Time; D011019:Pneumonia, Mycoplasma / Q000097:blood / Q000150:complications*
chemical_list: D001779:Blood Coagulation Factors