title: Skeletal and stereochemical diversification of tricyclic frameworks inspired by Ca(2+)-ATPase inhibitors, artemisinin and transtaganolide D.
abstract: Inspired by the common skeletal motifs of Ca(2+)-ATPases inhibitors involving artemisinin and transtaganolide D, small molecule collections with the three-dimensional structural diversity of tricyclic systems were designed and expeditiously synthesized (4-5 steps). A synthetic strategy featuring stereochemical diversification of ring-junctions and control of cyclization modes was devised to access varied molecular architectures in a systematic fashion.
authors.affiliation: Division of Chemistry, Graduate School of Science, and Division of Innovative Research, Hokkaido University, N21, W10, Sapporo 001-0021, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Oguri
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: Takahisa
authors.initials: T
authors.lastname: Hiruma
authors.forename: Hideaki
authors.initials: H
authors.lastname: Oikawa
mesh_terms: D037621:Artemisinins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism
chemical_list: D037621:Artemisinins; C538700:transtaganolide D; C031327:artemisinin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases