title: Distribution of bovine viral diarrhea virus antigen in aborted fetal and neonatal goats by immunohistochemistry.
abstract: Bovine viral diarrhea virus (BVDV) infection in goats can result in severe reproductive losses, with abortion rates reaching 80%. Infection with BVDV in aborted goat fetuses and stillborn kids can result in placentitis, encephalitis, myocarditis, and thymic depletion. This study investigates the distribution of viral antigen within the organ systems of aborted goat fetuses, stillborn kids, and nonviable kids infected with BVDV at various stages of gestation using immunohistochemistry (IHC). Virus antigen was detected within the placenta (8/13), thymus (4/9), heart (4/11), and brain (4/15) of affected goats. Uncommonly, BVDV antigen was detected within the skin (1/14), liver (1/13), kidney (1/12), lung (1/11), and trachea (1/3). BVDV antigen was not detected within the spleen (0/9), nasal turbinate (0/2), or thyroid (0/3). The results of this study indicate that placenta, heart, thymus, and brain are the most reliable tissues for BVDV antigen detection using IHC in aborted goat fetuses.
authors.affiliation: Oklahoma Animal Disease Diagnostic Laboratory, Oklahoma State University, Stillwater, OK 74076-7001, USA. Cathy.lamm@okstate.edu
authors.forename: C G
authors.initials: CG
authors.lastname: Lamm
authors.forename: C C
authors.initials: CC
authors.lastname: Broaddus
authors.forename: G R
authors.initials: GR
authors.lastname: Holyoak
mesh_terms: D000034:Abortion, Veterinary / Q000821:virology*; D000818:Animals; D000956:Antigens, Viral / Q000302:isolation & purification*; D001908:Diarrhea Viruses, Bovine Viral; D005260:Female; D005313:Fetal Death / Q000821:virology; D005333:Fetus / Q000821:virology*; D015511:Goat Diseases / Q000821:virology*; D006041:Goats; D007150:Immunohistochemistry; D011247:Pregnancy
chemical_list: D000956:Antigens, Viral