Neonatal programming of rat behavior by downregulation of alpha2A-adrenoreceptor gene expression in the brain.
Short-term knockdown of alpha2A-adrenergic receptor gene expression in the rat brain by siRNA or antisense oligodeoxynucleotide during the first days of life induced acute and long-lasting neurochemical and behavioral alterations. The acute effects in the neonatal rats were consistent with the known functions of the alpha2A-adrenergic receptors in the mature animals. The long-lasting alterations suggested involvement of receptor-specific gene expression during the critical period of brain development in early-life programming of anxiety-related behavior.
Dygalo
Nikolay N
NN
Institute of Cytology and Genetics, Novosibirsk, Russia. dygalo@bionet.nsc.ru
Kalinina
Tatyana S
TS
Shishkina
Galina T
GT
D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D003423:Critical Period, Psychological; D015536:Down-Regulation; D015870:Gene Expression; D006801:Humans; D009043:Motor Activity / Q000502:physiology; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics / Q000378:metabolism
D016376:Oligonucleotides, Antisense; D034741:RNA, Small Interfering; D018341:Receptors, Adrenergic, alpha-2