Drug induced linear IgA disease with unusual features: Koebner phenomenon, local insulin sensitivity and annular blister of the nipples.
Linear IgA disease is an autoimmune subepidermal bullous disease in which linear IgA deposits are found at the basement membrane zone. It is classically idiopathic but may be drug induced. We report on a patient with drug induced linear IgA disease who exhibited certain unusual and interesting clinical features including isomorphic Koebner response, annular blister of the nipples and local insulin sensitivity. To the best of our knowledge, these clinical features have not yet been reported in linear IgA disease.
Rashid Dar
Nasser
N
Department of Dermatology, Combined Military Hospital, Lahore, Pakistan.
Raza
Naeem
N
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects; D001327:Autoimmune Diseases / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy; D002086:Butylscopolammonium Bromide / Q000009:adverse effects; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A; D007333:Insulin Resistance; D008297:Male; D008795:Metronidazole / Q000009:adverse effects; D018727:Muscarinic Antagonists / Q000009:adverse effects; D009558:Nipples; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced / Q000473:pathology* / Q000628:therapy
D000890:Anti-Infective Agents; D007070:Immunoglobulin A; D018727:Muscarinic Antagonists; D008795:Metronidazole; D002086:Butylscopolammonium Bromide