title: The Finnish Diabetes Risk Score is associated with insulin resistance and progression towards type 2 diabetes.
abstract: OBJECTIVE
  The Finnish Diabetes Risk Score (FINDRISC) questionnaire is a practical screening tool to estimate the diabetes risk and the probability of asymptomatic type 2 diabetes. In this study we evaluated the usefulness of the FINDRISC to predict insulin resistance in a population at increased diabetes risk.
  
  
  METHODS
  Data of 771 and 526 participants in a cross-sectional survey (1996) and a cohort study (1997-2000), respectively, were used for the analysis. Data on the FINDRISC and oral glucose tolerance test parameters were available from each participant. The predictive value of the FINDRISC was cross-sectionally evaluated using the area under the curve-receiver operating characteristics method and by correlation analyses. A validation of the cross-sectional results was performed on the prospective data from the cohort study.
  
  
  RESULTS
  The FINDRISC was significantly correlated with markers of insulin resistance. The receiver operating characteristics-area under the curve for the prediction of a homeostasis model assessment insulin resistance index of more than five was 0.78 in the cross-sectional survey and 0.74 at baseline of the cohort study. Moreover, the FINDRISC at baseline was significantly associated with disease evolution (P < 0.01), which was defined as the change of glucose tolerance during the 3 yr follow-up.
  
  
  CONCLUSIONS
  The results indicate that the FINDRISC can be applied to detect insulin resistance in a population at high risk for type 2 diabetes and predict future impairment of glucose tolerance.
authors.affiliation: Medical Faculty Carl-Gustav-Carus of Technical University Dresden, Medical Clinic III, Building 10, Room 108, Fetscherstrasse 74, 01309 Dresden, Germany. peter.schwarz@uniklinikum-dresden.de
authors.forename: Peter E H
authors.initials: PE
authors.lastname: Schwarz
authors.forename: Jiang
authors.initials: J
authors.lastname: Li
authors.forename: Manja
authors.initials: M
authors.lastname: Reimann
authors.forename: Alta E
authors.initials: AE
authors.lastname: Schutte
authors.forename: Antje
authors.initials: A
authors.lastname: Bergmann
authors.forename: Markolf
authors.initials: M
authors.lastname: Hanefeld
authors.forename: Stefan R
authors.initials: SR
authors.lastname: Bornstein
authors.forename: Jan
authors.initials: J
authors.lastname: Schulze
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Jaana
authors.initials: J
authors.lastname: Lindström
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D012372:ROC Curve; D012306:Risk