title: Fascin can be an auxiliary immunomarker of ovarian granulosa cell tumors: comparison with calretinin and inhibin-alpha.
abstract: The histopathologic diagnosis of granulosa cell tumor adult type (AGCT) can be supported by the use of established immunomarkers such as inhibin-alpha and calretinin. Previously unreported data is presented on the detection of fascin in AGCT, in nonneoplastic granulosa cells and in other types of sex-cord stromal tumors. In addition, by staining a panel of various tumors, potentially included in the differential diagnosis of AGCT, we assessed the value of fascin as an auxiliary AGCT immunomarker. Intense and strong fascin staining may assist in cases with ambiguous calretinin or inhibin-alpha staining. On the contrary, absence of fascin should question a provisional morphologic diagnosis of AGCT.
authors.affiliation: Department of Pathology, University Hospital of Larissa, Medical School of Thessaly, Larissa, Greece. ekosto@med.uth.gr
authors.forename: E
authors.initials: E
authors.lastname: Kostopoulou
authors.forename: S
authors.initials: S
authors.lastname: Angelidou
authors.forename: A
authors.initials: A
authors.lastname: Daponte
authors.forename: C
authors.initials: C
authors.lastname: Galani
authors.forename: I
authors.initials: I
authors.lastname: Chiotoglou
authors.forename: A
authors.initials: A
authors.lastname: Terzis
authors.forename: G
authors.initials: G
authors.lastname: Koukoulis
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D064032:Calbindin 2; D002352:Carrier Proteins / Q000032:analysis*; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007265:Inhibins / Q000032:analysis; D008840:Microfilament Proteins / Q000032:analysis*; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000473:pathology; D064030:S100 Calcium Binding Protein G / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; C576764:CALB2 protein, human; D064032:Calbindin 2; D002352:Carrier Proteins; C502658:FSCN1 protein, human; D008840:Microfilament Proteins; D064030:S100 Calcium Binding Protein G; C094377:inhibin-alpha subunit; D007265:Inhibins