Association of chemokines receptor (CCR5 Delta32) in idiopathic recurrent miscarriages among north Indians.
OBJECTIVE
Human reproduction is a complex process involving multiple factors for the success of pregnancy. Chemokines are one of the immunomodulators which may determine pregnancy outcome. In the present study, we have tested genetic association between CCR5 Delta32 polymorphism and idiopathic recurrent miscarriages (IRM) among north Indians.


METHODS
Two hundred patients and 300 age, sex and ethnically matched controls were genotyped for CCR5 Delta32 polymorphism, genotype and allele frequencies were compared in both the groups.


RESULTS
IRM patients had a three times higher (5.5 vs. 1.7%) frequency of heterozygote genotype (P = 0.0335, OR = 3.43; 95% CI = 1.17-10.04). Allele frequency in IRM patients was 3.7 and 0.83% among controls and the differences were statistically significant (P = 0.0349, OR = 3.37; 95% CI = 1.16-9.76).


CONCLUSIONS
Our results demonstrated that it had a higher frequency of CCR5 Delta32 at allelic level suggesting a possible susceptibility trend (OR = 3.43) and CCR5 Delta32 may be a potential genetic risk factor for IRM.
Parveen
Farah
F
Department of Biotechnology, Bundelkhand University, Jhansi, UP, India.
Tripathi
Gaurav
G
Singh
Bhanumati
B
Agrawal
Suraksha
S
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007194:India; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D055815:Young Adult
D019713:Receptors, CCR5