The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer.
OBJECTIVE
The aim of the study was to determine the activity of cathepsin D (CTSD) and alpha-1-antitrypsin (AAT) in the blood serum of women with cervical carcinoma treated with different modes of therapy.


METHODS
The study was conducted on 68 women suffering from carcinoma of the uterine cervix, that were irradiated intracavitarily by a Selectron LDR brachytherapy unit. Additionally, all patients were treated with different therapy methods according to clinical stage.


RESULTS
In women with cervical cancer, CTSD activity was higher while AAT activity was lower both before and after brachytherapy sessions as compared to controls. Six months after the end of therapy, the activity of CTSD and AAT reverted back to the values characteristic for healthy women.


CONCLUSIONS
The estimation of cathepsin D and alpha-1-antitrypsin activity during the course of cervical cancer management may be useful in early detection of potential recurrence and/or widespread metastasis formation.
Woźniak
B
B
Department and Clinic of Neurosurgery and Neurotraumatology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland.
Mila-Kierzenkowska
C
C
Woźniak
A
A
Drewa
G
G
Sopońska
M
M
Drewa
T
T
Krzyzyńska-Malinowska
E
E
Makarewicz
R
R
Kowalski
T
T
Szmytkowska
K
K
D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D001918:Brachytherapy; D016022:Case-Control Studies; D002402:Cathepsin D / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood*; D018714:Radiotherapy, Adjuvant; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000628:therapy*; D000515:alpha 1-Antitrypsin / Q000097:blood*
D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D000515:alpha 1-Antitrypsin; D002402:Cathepsin D