Stromal clonogenic precursors of hemopoietic microenvironment and their rank in the hierarchy of mesenchymal stem cells.
The hierarchy of stromal precursor cells was studied. Changes in the number of fibroblast CFU in foci forming in irradiated recipients were analyzed. These precursor cells are most close known descendants of mesenchymal stem cells, while inducible precursors rank lower in the hierarchy and are the cells directly enlarging the hemopoietic area in irradiated recipients.
Nifontova
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IN
Hematology Research Center, Russian Academy of Medical Sciences, Moscow, Russia. iranifonrova@yandex.ru
Svinareva
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DA
Drize
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NJ
D000818:Animals; D002452:Cell Count; D049109:Cell Proliferation; D002478:Cells, Cultured; D004777:Environment; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D059630:Mesenchymal Stem Cells / Q000145:classification* / Q000166:cytology / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D017154:Stromal Cells / Q000166:cytology / Q000502:physiology*