title: [Detection of gene mutations of SCN5A in 7 patients with Brugada syndrome].
abstract: OBJECTIVE
  Brugada syndrome is linked to sodium channel mutations and could induce arrhythmias that even lead to sudden death. The purpose of this study was to detect if there was gene mutation of SCN5A in 7 patients with Brugada syndrome and explore the molecular genetic characteristics of this disease.
  
  
  METHODS
  Genomic DNA was extracted from peripheral blood of all 7 patients with Brugada syndrome and 41 pairs of PCR primers were designed to amplify all the 28 exons of SCN5A.
  
  
  RESULTS
  There was no novel mutation in exons of Gene SCN5A in these patients with Brugada syndrome.
  
  
  CONCLUSIONS
  Brugada syndrome might associated gene mutation or other mechanisms independent of SCN5A gene mutation.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
authors.forename: Bin-bin
authors.initials: BB
authors.lastname: Yuan
authors.forename: Qi-jun
authors.initials: QJ
authors.lastname: Shan
authors.forename: Bing
authors.initials: B
authors.lastname: Yang
authors.forename: Ming-long
authors.initials: ML
authors.lastname: Chen
authors.forename: Jian-gang
authors.initials: JG
authors.lastname: Zou
authors.forename: Chun
authors.initials: C
authors.lastname: Chen
authors.forename: Dong-jie
authors.initials: DJ
authors.lastname: Xu
authors.forename: Ke-jiang
authors.initials: KJ
authors.lastname: Cao
mesh_terms: D000328:Adult; D053840:Brugada Syndrome / Q000235:genetics*; D004252:DNA Mutational Analysis; D005091:Exons; D006801:Humans; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics*; D009154:Mutation; D062554:NAV1.5 Voltage-Gated Sodium Channel; D015222:Sodium Channels / Q000235:genetics*
chemical_list: D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels