title: Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia.
abstract: This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. isaev@genebee.msu.su
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashook
authors.forename: E Y
authors.initials: EY
authors.lastname: Plotnikov
authors.forename: T G
authors.initials: TG
authors.lastname: Khryapenkova
authors.forename: E R
authors.initials: ER
authors.lastname: Lozier
authors.forename: Y V
authors.initials: YV
authors.lastname: Doludin
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D062565:Acid Sensing Ion Channels; D000138:Acidosis / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000503:physiopathology; D016923:Cell Death; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: C568266:ASIC1 protein, human; D062565:Acid Sensing Ion Channels; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D015222:Sodium Channels; D018698:Glutamic Acid