Every slow-wave impulse is associated with motor activity of the human stomach.
Using a newly developed high-resolution three-dimensional magnetic detector system (3D-MAGMA), we observed periodical movements of a small magnetic marker in the human stomach at the typical gastric slow-wave frequency, that is 3 min(-1). Thus we hypothesized that each gastric slow wave induces a motor response that is not strong enough to be detected by conventional methods. Electrogastrographies (EGG, Medtronic, Minneapolis, MN) for measurement of gastric slow waves and 3D-MAGMA (Innovent, Jena, Germany) measurements were simultaneously performed in 21 healthy volunteers (10 men, 40.4+/-13.6 yr; 11 women, 35.8+/-11.6 yr). The 3D-MAGMA system contains 27 highly sensitive magnetic field sensors that are able to locate a magnetic pill inside a human body with an accuracy of +/-5 mm or less in position and +/-2 degrees in orientation at a frequency of 50 Hz. Gastric transit time of the magnetic marker ranged from 19 to 154 min. The mean dominant EGG frequency while the marker was in the stomach was 2.87+/-0.15 cpm. The mean dominant 3D-MAGMA frequency during this interval was nearly identical; that is, 2.85+/-0.15 movements per minute. We observed a strong linear correlation between individual dominant EGG and 3D-MAGMA frequency (R=0.66, P=0.0011). Our findings suggest that each gastric slow wave induces a minute contraction that is too small to be detected by conventional motility investigations but can be recorded by the 3D-MAGMA system. The present slow-wave theory that assumes that the slow wave is a pure electrical signal should be reconsidered.
Hocke
Michael
M
Clinic of Internal Medicine II, Department of Gastroenterology, Hepatology and Infectious Diseases, Friedrich-Schiller-University Jena, Erlanger Allee 101, D-07747 Jena, Germany. michael.hocke@klinikum-meiningen.de
Schöne
Ulrike
U
Richert
Hendryk
H
Görnert
Peter
P
Keller
Jutta
J
Layer
Peter
P
Stallmach
Andreas
A
D000328:Adult; D004594:Electrophysiology; D005260:Female; D005583:Fourier Analysis; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008280:Magnetics / Q000295:instrumentation / Q000379:methods; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D013270:Stomach / Q000502:physiology*