Granulosa-lutein cell growth differentiation factor-9 (GDF-9) messenger RNA and protein expression in in vitro fertilization (IVF) cycles: relation to characteristics of ovulation induction and IVF.
Granulosa-lutein cell growth differentiation factor-9 (GDF-9), a member of the transforming growth factor beta (TGF-beta) superfamily, is an oocyte-derived factor expressed throughout the development of the maturing follicle and is essential in early follicular development and fertility. Both GDF-9 messenger RNA and protein are detected in granulosa-lutein cells. A statistically significant correlation between GDF-9 expression and the number of dominant follicles on the day human chorionic gonadotropin is administered also is demonstrated. Human granulosa-lutein cell GDF-9 expression may play a role in folliculogenesis dependent on follicle-stimulating hormone in the in vitro fertilization cycle.
Huang
Hong-Yuan
HY
Department of Obstetrics and Gynecology, Lin-Kou Medical Center, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan. hongyuan@cgmh.org.tw
Wang
Hsin-Shih
HS
Chan
She-Hung
SH
Lee
Chyi-Long
CL
Wang
Chia-Woei
CW
Soong
Yung-Kuei
YK
D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006107:Granulosa Cells / Q000378:metabolism*; D055429:Growth Differentiation Factor 9 / Q000378:metabolism*; D006801:Humans; D008184:Luteal Cells / Q000378:metabolism*; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012333:RNA, Messenger / Q000378:metabolism*; D012189:Retrospective Studies
D006063:Chorionic Gonadotropin; D055429:Growth Differentiation Factor 9; D012333:RNA, Messenger