Evaluation of the Role of FMLF chemotaxic peptide receptors in umbilical cord blood granulocytes from newborns at risk of infectious inflammatory diseases.
We studied the role of receptors with high and low affinity for fMLF chemotaxic peptide in the generation of active oxygen species by umbilical cord blood granulocytes from newborns with normal neonatal period, born after normal or complicated gestation, in children with manifestations of bacterial infection born after complicated pregnancy, and in granulocytes of non-pregnant women with normal reproductive function. Granulocytes of children born after complicated pregnancy exhibited high reactivity in induction of respiratory burst in a wide range of fMLF concentrations. The presentation of receptors with high and low affinity on granulocytes during initiation of the respiratory burst differs in children born after complicated pregnancy and in healthy babies born after normal gestation. Presumably, the detected differences result from high expression of receptors with low affinity for fMLF and disorders or immaturity of mechanisms responsible for receptor inactivation.
Safronova
V G
VG
Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Russia. safronova@icb.psn.ru
Matveeva
N K
NK
Mal'tseva
V N
VN
Bondar'
O E
OE
Van'ko
L V
LV
Sukhikh
G T
GT
D016022:Case-Control Studies; D002478:Cells, Cultured; D003141:Communicable Diseases / Q000097:blood / Q000151:congenital / Q000209:etiology / Q000378:metabolism; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000378:metabolism / Q000473:pathology; D044042:Receptors, Formyl Peptide / Q000378:metabolism / Q000502:physiology*; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood* / Q000209:etiology / Q000378:metabolism / Q000473:pathology
D009842:Oligopeptides; D044042:Receptors, Formyl Peptide; D009240:N-Formylmethionine Leucyl-Phenylalanine; C046832:t-butyloxycarbonyl-methionyl-leucyl-phenylalanine