Bacterial multidrug transport through the lens of the major facilitator superfamily.
Multidrug transporters are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell. Through this function, they render cells resistant to multiple drugs. These transporters are found in many different families of transport proteins, of which the largest is the major facilitator superfamily. Multidrug transporters from this family are highly represented in bacteria and studies of them have provided important insight into the mechanism underlying multidrug transport. This review summarizes the work carried out on these interesting proteins and underscores the differences and similarities to other transport systems.
Fluman
Nir
N
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
Bibi
Eitan
E
D024881:Drug Resistance, Bacterial / Q000502:physiology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D026901:Membrane Transport Proteins / Q000502:physiology*; D008958:Models, Molecular; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000502:physiology*; D055672:Static Electricity
D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins