Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro degradation process.
Poly(DL-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(DL-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy.
Stevanović
M
M
Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia. magir@eunet.yu
Jordović
B
B
Uskoković
D
D
D001205:Ascorbic Acid / Q000378:metabolism* / Q000493:pharmacokinetics*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure*; D011098:Polyglactin 910 / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet
D011098:Polyglactin 910; D001205:Ascorbic Acid