[Matrix metalloproteinase-1 gene -519A/G polymorphism and the risk of coronary heart disease in Northern Chinese Han population].
OBJECTIVE
To investigate the relationship between matrix metalloproteinase (MMP) 1 gene -519A/G polymorphism and the risk of coronary heart disease (CHD) in Northern Chinese Han population.


METHODS
A total of 517 patients with CHD and 380 healthy adults diagnosed by coronary angiography were genotyped by polymerase chain reaction-restriction fragment length polymorphism and DNA sequence technology for the -519A/G polymorphism in MMP1 gene.


RESULTS
(1) The frequency of AA genotype was significantly higher in patients with CHD than that in controls [67.70% (350/517) vs. 40.26% (153/380), OR = 1.64, P < 0.001, 95%CI: 1.44 - 1.86]. People carrying A allele had increased risk for CHD (OR = 1.49, P < 0.001, 95%CI: 1.33 - 1.69). (2) The frequency of AA genotype was higher in patients with acute coronary syndrome (ACS) than patients with stable angina pectoris [68.81% (278/404) vs. 51.76% (44/85), P < 0.01, 95%CI: 1.04 - 1.27]. The A allele carriers were more likely to develop ACS (OR = 1.11, 95%CI: 1.01 - 1.21, P < 0.05).


CONCLUSIONS
Our data shows MMP1 gene -519A/G polymorphism is associated with the risk of CHD, and A allele carriers are more susceptible for CHD in Northern Chinese Han population.
Han
Ya-Ling
YL
Department of Cardiology, Shenyang General Hospital, Cardiovascular Research Institute of People's Liberation Army, Shenyang 110016, China. hanyal@mail.sy.ln.cn
Wu
Ze-Feng
ZF
Zhang
Xiao-Lin
XL
Yan
Cheng-Hui
CH
Yang
Yong
Y
Xi
Su-Ya
SY
Kang
Jian
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D003327:Coronary Disease / Q000208:ethnology / Q000209:etiology* / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1