title: Paralytic ileus associated with capecitabine.
abstract: Paralytic ileus is a temporary arrest of intestinal peristalsis. We report on two patients with breast cancer who developed paralytic ileus following treatment with capecitabine. The pathophysiology of this disorder and its possible connection to capecitabine are described with the aim of promoting the early recognition of the clinical picture so that unnecessary surgery can be avoided.
authors.affiliation: UO di Oncologia Medica, Ospedale Renzetti, Lanciano, Chieti, Italy. laudadio@oncologialanciano.it
authors.forename: Lucio
authors.initials: L
authors.lastname: Laudadio
authors.forename: Edoardo
authors.initials: E
authors.lastname: Biondi
authors.forename: Nicola
authors.initials: N
authors.lastname: D'Ostilio
authors.forename: Alisia
authors.initials: A
authors.lastname: Cesta
authors.forename: Francesca
authors.initials: F
authors.lastname: Di Giandomenico
authors.forename: Samantha
authors.initials: S
authors.lastname: Forciniti
authors.forename: Antonio
authors.initials: A
authors.lastname: Nuzzo
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D000069287:Capecitabine; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced* / Q000503:physiopathology; D008875:Middle Aged
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000069287:Capecitabine; D005472:Fluorouracil