Interplaying factors for the formation of photoswitchable beta-hairpins: the advantage of a flexible switch.
A series of peptidomimetics intended to promote the beta-hairpin motif have been studied. Structural variations include a turn region with and without a photoswitchable chromophore, and strands with amino acid side chains supporting various degrees of interstrand interactions for hairpin stabilisation. The propensity of the compounds to form beta-hairpins was evaluated experimentally by NMR spectroscopy, translational self-diffusion studies and CD spectroscopy. In the presence of hairpin stabilising interstrand interactions, the structurally flexible stilbene chromophore appeared to be well compatible with the imposed secondary structure.
Varedian
Miranda
M
Department of Biochemistry and Organic Chemistry, Uppsala University, Uppsala, Sweden.
Erdélyi
Máté
M
Persson
Asa
A
Gogoll
Adolf
A
D002942:Circular Dichroism; D008027:Light; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D010777:Photochemistry; D017433:Protein Structure, Secondary
D010455:Peptides