Effect of neuromedin on activity of lactate dehydrogenase in mitochondrial fraction of the brain in rats with thermal injury.
We studied enzyme systems (lactate dehydrogenase) of mitochondria in cerebral nerve cells in experimental encephalopathy developing after thermal injury. In animals receiving neuromedin at the early terms after injury, the ratio of forward to reverse lactate dehydrogenase reactions significantly increased over the first day after injury and returned to normal on day 7.
Khrulev
S E
SE
Research Institute of Traumatology and Orthopedics, Federal Biomedical Agency, Nizhnii Novgorod, Russia. khroulev@mail.ru
Zimin
Yu V
YV
Solovyeva
A G
AG
Razmakhov
A M
AM
Luzan
A S
AS
D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D001930:Brain Injuries / Q000201:enzymology* / Q000503:physiopathology; D002056:Burns / Q000201:enzymology* / Q000503:physiopathology; D004789:Enzyme Activation / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar
D000634:Aminoquinolines; C049860:amiridine; D007770:L-Lactate Dehydrogenase