title: Hepatectomy for liver metastasis of colorectal cancer.
abstract: OBJECTIVE
  The objective of this study was to investigate whether hepatic resection (HR) can increase the survival of liver metastasis of colorectal cancer (CRC).
  
  
  METHODS
  CRC patients (n=669) with liver metastasis treated at the Zhongshan Hospital, Fudan University from 1/2000 to 7/2007 were included in the study to investigate the relationship between HR and cancer survival.
  
  
  RESULTS
  CRC patients (n=669) with liver metastases who had primary tumor resection were grouped in synchronous liver metastasis (SLM; 56.7%, n=379) and metachronous liver metastasis (MLM) groups (43.3%, n=290). Hepatic resection rates were lower (32.5%, n=123) in the SLM than the MLM group (44.8%, n=130, P<0.05). The 30-day mortality rate in the MLM (2.3%) was significantly lower than SLM (2.4%) groups. The 5-year survival rates (36.6%) was same compared to SLM group (33.1%, P>0.05). One-, 2-, and 3-year survival of stages I and II operation cases were 92.5% vs 86.5%, 0.7% vs 58.0%, and 42.1% vs 44.9% (P>0.05) in the SLM group, respectively. Recurrence after first hepatic resection associated with a 2.23-fold increased risk of death (P<0.01). Incision margins larger than 1 cm and HR for recurrence associated with 34% and 27% (P<0.05) decreased death risk.
  
  
  CONCLUSIONS
  Hepatic resection could help the survival of liver metastasis of colorectal cancer, and stage I surgery is safe for this disease.
authors.affiliation: Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, People's Republic of China. xujmin@yahoo.com.cn
authors.forename: Jianmin
authors.initials: J
authors.lastname: Xu
authors.forename: Ye
authors.initials: Y
authors.lastname: Wei
authors.forename: Yunshi
authors.initials: Y
authors.lastname: Zhong
authors.forename: Jia
authors.initials: J
authors.lastname: Fan
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Lunxiu
authors.initials: L
authors.lastname: Qin
authors.forename: Li
authors.initials: L
authors.lastname: Ren
authors.forename: Xinyu
authors.initials: X
authors.lastname: Qin
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D016016:Proportional Hazards Models; D012008:Recurrence; D012189:Retrospective Studies; D016019:Survival Analysis; D013997:Time Factors