[New insight into DNA methylation in CML and its effect on clinical outcome--review].
All kinds of tumors have their specific DNA methylation patterns. The study of DNA methylation changes in chronic myelogenous leukemia includes (1) the hypomethylation of carcinogenic gene, (2) the hypermethylation of tumor-suppressing gene, and (3) the hypermethylation of fusion gene. In this paper, DNA methylation change in chronic myeloid leukemia (CML) and its role in clinical stages and evaluation of prognosis were reviewed so as to illuminate the relationship between DNA methylation and CML.
Tang
Yong
Y
Department of Hematology, The Ninth People Hospital, Shanghai Jiaotong University Medical College, Shanghai 200011, China.
Hu
Jun-Pei
JP
D019175:DNA Methylation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis