Cancer gene silencing without DNA hypermethylation.
Both DNA hypermethylation and Polycomb-mediated histone methylation induce gene silencing in cancer, but largely in two separate paths. Hence, different pharmacologic approaches are required to reactivate genes silenced by distinct epigenetic mechanisms.
Yu
Qiang
Q
Cancer Biology and Pharmacology, Genome Institute of Singapore, A*STAR (Agency for Science, Technology and Research), Biopolis, Singapore. yuq@gis.a-star.edu.sg
D000818:Animals; D019175:DNA Methylation; D020868:Gene Silencing; D006657:Histones / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics*
D006657:Histones