title: Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence.
abstract: Very low (nano- and subnanomolar) concentrations of 10-(6'-plastoquinonyl) decyltriphenylphosphonium (SkQ1) were found to prolong lifespan of a fungus (Podospora anserina), a crustacean (Ceriodaphnia affinis), an insect (Drosophila melanogaster), and a mammal (mouse). In the latter case, median lifespan is doubled if animals live in a non-sterile vivarium. The lifespan increase is accompanied by rectangularization of the survival curves (an increase in survival is much larger at early than at late ages) and disappearance of typical traits of senescence or retardation of their development. Data summarized here and in the preceding papers of this series suggest that mitochondria-targeted antioxidant SkQ1 is competent in slowing down execution of an aging program responsible for development of age-related senescence.
authors.affiliation: Petrov Institute of Oncology, St. Petersburg, 197758, Russia.
authors.forename: V N
authors.initials: VN
authors.lastname: Anisimov
authors.forename: L E
authors.initials: LE
authors.lastname: Bakeeva
authors.forename: P A
authors.initials: PA
authors.lastname: Egormin
authors.forename: O F
authors.initials: OF
authors.lastname: Filenko
authors.forename: E F
authors.initials: EF
authors.lastname: Isakova
authors.forename: V N
authors.initials: VN
authors.lastname: Manskikh
authors.forename: V M
authors.initials: VM
authors.lastname: Mikhelson
authors.forename: A A
authors.initials: AA
authors.lastname: Panteleeva
authors.forename: E G
authors.initials: EG
authors.lastname: Pasyukova
authors.forename: D I
authors.initials: DI
authors.lastname: Pilipenko
authors.forename: T S
authors.initials: TS
authors.lastname: Piskunova
authors.forename: I G
authors.initials: IG
authors.lastname: Popovich
authors.forename: N V
authors.initials: NV
authors.lastname: Roshchina
authors.forename: O Yu
authors.initials: OY
authors.lastname: Rybina
authors.forename: V B
authors.initials: VB
authors.lastname: Saprunova
authors.forename: T A
authors.initials: TA
authors.lastname: Samoylova
authors.forename: A V
authors.initials: AV
authors.lastname: Semenchenko
authors.forename: M V
authors.initials: MV
authors.lastname: Skulachev
authors.forename: I M
authors.initials: IM
authors.lastname: Spivak
authors.forename: E A
authors.initials: EA
authors.lastname: Tsybul'ko
authors.forename: M L
authors.initials: ML
authors.lastname: Tyndyk
authors.forename: M Yu
authors.initials: MY
authors.lastname: Vyssokikh
authors.forename: M N
authors.initials: MN
authors.lastname: Yurova
authors.forename: M A
authors.initials: MA
authors.lastname: Zabezhinsky
authors.forename: V P
authors.initials: VP
authors.lastname: Skulachev
mesh_terms: D000375:Aging / Q000187:drug effects*; D000818:Animals; D001692:Biological Transport; D002478:Cells, Cultured; D033361:Cladocera / Q000187:drug effects* / Q000502:physiology; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D008136:Longevity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D010971:Plastoquinone / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D048468:Podospora / Q000187:drug effects* / Q000235:genetics / Q000502:physiology
chemical_list: D010971:Plastoquinone