Synthesis of novel Gn-RH analogues using Ugi-4MCR.
An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data.
Arabanian
Armin
A
Peptide Chemistry Research Group, K. N. Toosi University of Technology, PO Box 15875-4416, Tehran, Iran.
Mohammadnejad
Mahdieh
M
Balalaie
Saeed
S
Gross
Jürgen H
JH
D000447:Aldehydes / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003486:Cyanides / Q000737:chemistry*; D015195:Drug Design; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry; D017434:Protein Structure, Tertiary; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013696:Temperature; D017329:Triptorelin Pamoate / Q000737:chemistry
D000447:Aldehydes; D003486:Cyanides; D010455:Peptides; D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone