title: Zoonotic vaccinia virus: clinical and immunological characteristics in a naturally infected patient.
abstract: Vaccinia virus was used as vaccine to eradicate smallpox. We report a zoonotic case of vaccinia virus infection in a 30-year-old patient who became infected after handling sick dairy cattle. The patient had inflamed lesions and systemic symptoms. Laboratory findings were indicative of down-modulated immune responses to the virus.
authors.affiliation: Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Giliane S
authors.initials: GS
authors.lastname: Trindade
authors.forename: Maria I C
authors.initials: MI
authors.lastname: Guedes
authors.forename: Betânia P
authors.initials: BP
authors.lastname: Drumond
authors.forename: Bruno E F
authors.initials: BE
authors.lastname: Mota
authors.forename: Jônatas S
authors.initials: JS
authors.lastname: Abrahão
authors.forename: Zélia I P
authors.initials: ZI
authors.lastname: Lobato
authors.forename: Juliana A S
authors.initials: JA
authors.lastname: Gomes
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Corrêa-Oliveira
authors.forename: Maurício L
authors.initials: ML
authors.lastname: Nogueira
authors.forename: Erna G
authors.initials: EG
authors.lastname: Kroon
authors.forename: Flávio G
authors.initials: FG
authors.lastname: da Fonseca
mesh_terms: D000328:Adult; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000635:transmission* / Q000821:virology*; D002478:Cells, Cultured; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D012867:Skin / Q000473:pathology; D014615:Vaccinia / Q000175:diagnosis* / Q000276:immunology / Q000662:veterinary*; D014616:Vaccinia virus / Q000276:immunology / Q000302:isolation & purification*; D015047:Zoonoses / Q000635:transmission* / Q000821:virology*
chemical_list: D007371:Interferon-gamma