title: Male infertility related to an aberrant karyotype, 46,XY,9ph,9qh+.
abstract: OBJECTIVE
  To report a man with primary infertility and variant karyotype.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Private practice.
  
  
  METHODS
  A 37-year-old man with 4 years of primary infertility due to oligoasthenozoospermia.
  
  
  METHODS
  None.
  
  
  METHODS
  G- and C-banding. Polymerase chain reaction for SRY, DBY, RBMY, DAZ, AMELX, and AMELY.
  
  
  RESULTS
  G-band analysis of the proband revealed a 46,XY,9ph,9qh+ karyotype. C-banding confirmed increase in the heterochromatin in one chromosome 9 and inversion in the other.
  
  
  CONCLUSIONS
  The morphologic difference between the homologous chromosomes 9 may have been responsible for an error in crossing-over, leading to aberrant spermatozoa and consequently to infertility.
authors.affiliation: Genetics and Human Reproduction Division, Gynecology and Obstetric Department, Santo André, Brazil. sintia.morf@epm.br
authors.forename: Síntia Iole Nogueira
authors.initials: SI
authors.lastname: Belangero
authors.forename: Denise Maria
authors.initials: DM
authors.lastname: Christofolini
authors.forename: Bianca
authors.initials: B
authors.lastname: Bianco
authors.forename: Marcello Machado
authors.initials: MM
authors.lastname: Gava
authors.forename: Eric Roger
authors.initials: ER
authors.lastname: Wroclawski
authors.forename: Caio Parente
authors.initials: CP
authors.lastname: Barbosa
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D007446:Chromosome Inversion; D002892:Chromosomes, Human, Pair 22; D002899:Chromosomes, Human, Pair 9; D041322:Chromosomes, Human, Y; D004247:DNA / Q000097:blood / Q000235:genetics; D023961:Gonadal Dysgenesis, 46,XX / Q000235:genetics*; D006061:Gonadal Dysgenesis, 46,XY / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D051876:Sex-Determining Region Y Protein / Q000235:genetics; D013081:Sperm Motility / Q000235:genetics
chemical_list: D051876:Sex-Determining Region Y Protein; D004247:DNA