[Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy].
BACKGROUND
Metronidazole is a widely prescribed treatment for amoebic and anaerobic germ infections. Its neurologic toxicity is rare but can be serious.


METHODS
We report the case of a 27-year-old male patient, treated with metronidazole for a cerebral abscess. He presented with a cerebellar syndrome and peripheral neuropathy at a cumulative metronidazole dose of 60g. The MRI aspect of the cerebellar lesions in addition to their reversibility after treatment cessation led to the diagnosis of metronidazole induced neurologic toxicity.


CONCLUSIONS
The occurrence of neurologic disorders in patients treated with metronidazole must suggest drug toxicity and lead to cessation of treatment.
Toumi
S
S
Service de médecine interne, CHU de Sahloul, route de Ceinture, Sousse, Tunisie. toumisarra@yahoo.fr
Hammouda
M
M
Essid
A
A
Medimagh
L
L
Slamia
L Ben
LB
Laouani-Kechrid
C
C
D000328:Adult; D001922:Brain Abscess / Q000188:drug therapy*; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000175:diagnosis; D003244:Consciousness Disorders / Q000139:chemically induced; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D012678:Sensation Disorders / Q000139:chemically induced
D008795:Metronidazole