Regulation of T-helper-cell lineage development by osteopontin: the inside story.
Studies of osteopontin (OPN)-dependent regulation of immune responses have focused on the cytokine activities of the secreted form of this protein. Recent evidence has revealed that an intracellular form of OPN expressed by dendritic cells regulates the expression of pro-inflammatory cytokines and the differentiation of T helper (T(H))-cell lineages. In this Opinion article, we discuss the properties of both OPN isoforms and their respective contributions to the immune response. We propose that cell-type-specific expression of secreted and intracellular OPN regulates the development of distinct effector T(H) cells, including that of T(H)1 and T(H)17 cells.
Cantor
Harvey
H
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA. Harvey_Cantor@dfci.harvard.edu
Shinohara
Mari L
ML
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D020381:Interleukin-17 / Q000096:biosynthesis; D008213:Lymphocyte Activation; D038041:Lymphopoiesis; D008264:Macrophages / Q000378:metabolism; D053495:Osteopontin / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology / Q000378:metabolism; D014777:Virus Diseases / Q000276:immunology
D020381:Interleukin-17; D053495:Osteopontin