title: Genetic association study of the P-type ATPase ATP13A2 in late-onset Parkinson's disease.
abstract: A role of ATP13A2 in early-onset Parkinsonism (EOP) has been proposed. Conversely, the contribution of this ATPase to late-onset Parkinson's disease (PD) remains unexplored. We therefore conducted a case-control association study in this age-of-onset group with PD. The initial sample was of German origin and consisted of 220 patients with late-onset PD (mean age of onset 60.1 years) and 232 age-matched unrelated controls. Five single nucleotide polymorphisms (SNPs) covering ATP13A2 and its common haplotypes were genotyped. The overall association results in this sample were negative. Interestingly, gender stratification gave a positive result for SNP rs11203280 (P(UNC) = 0.016) in men. This result could not be reproduced in a replication sample of German and Serbian origin composed of 161 patients with late-onset PD (mean age of onset 51.7 years) and 150 age- and ethnic-matched controls. In conclusion, we found no consistent evidence for an association between ATP13A2 and late-onset PD.
authors.affiliation: Department of Neurology, University of Lübeck, Lübeck, Germany.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Rakovic
authors.forename: Barbara
authors.initials: B
authors.lastname: Stiller
authors.forename: Ana
authors.initials: A
authors.lastname: Djarmati
authors.forename: Antonia
authors.initials: A
authors.lastname: Flaquer
authors.forename: Jan
authors.initials: J
authors.lastname: Freudenberg
authors.forename: Mohammad-Reza
authors.initials: MR
authors.lastname: Toliat
authors.forename: Michael
authors.initials: M
authors.lastname: Linnebank
authors.forename: Vladimir
authors.initials: V
authors.lastname: Kostic
authors.forename: Katja
authors.initials: K
authors.lastname: Lohmann
authors.forename: Sebastian
authors.initials: S
authors.lastname: Paus
authors.forename: Peter
authors.initials: P
authors.lastname: Nürnberg
authors.forename: Christian
authors.initials: C
authors.lastname: Kubisch
authors.forename: Christine
authors.initials: C
authors.lastname: Klein
authors.forename: Ullrich
authors.initials: U
authors.lastname: Wüllner
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ramirez
mesh_terms: D000328:Adult; D017668:Age of Onset; D000368:Aged; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D006180:Proton-Translocating ATPases / Q000235:genetics*
chemical_list: C514983:ATP13A2 protein, human; D006180:Proton-Translocating ATPases