title: X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice.
abstract: Using X-ray fluorescent computed tomography (XFCT), the in vivo and ex vivo cerebral distribution of a stable-iodine-labeled cerebral perfusion agent, iodoamphetamine analog (127I-IMP), has been recorded in the brains of mice. In vivo cerebral perfusion in the cortex, hippocampus and thalamus was depicted at 0.5 mm in-plane spatial resolution. Ex vivo XFCT images at 0.25 mm in-plane spatial resolution allowed the visualisation of the detailed structures of these regions. The quality of the XFCT image of the hippocampus was comparable with the 125I-IMP autoradiogram. These results highlight the sensitivity of XFCT and its considerable potential to evaluate cerebral perfusion in small animals without using radioactive agents.
authors.affiliation: Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba-shi, Ibaraki 305-8575, Japan. ttakeda@md.tsukuba.ac.jp
authors.forename: Tohoru
authors.initials: T
authors.lastname: Takeda
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
authors.forename: Qingkai
authors.initials: Q
authors.lastname: Huo
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yuasa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Hyodo
authors.forename: F Avraham
authors.initials: FA
authors.lastname: Dilmanian
authors.forename: Takao
authors.initials: T
authors.lastname: Akatsuka
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D006624:Hippocampus / Q000098:blood supply / Q000000981:diagnostic imaging; D007090:Image Interpretation, Computer-Assisted; D007456:Iodine Isotopes; D020367:Iofetamine / Q000493:pharmacokinetics*; D051379:Mice; D019047:Phantoms, Imaging; D013788:Thalamus / Q000098:blood supply / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D007456:Iodine Isotopes; D020367:Iofetamine