title: Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques.
abstract: Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.
authors.affiliation: Department of Medical Microbiology, School of Medicine, University of California, Davis, California 95616, USA. mdgeorge@ucdavis.edu
authors.forename: Michael D
authors.initials: MD
authors.lastname: George
authors.forename: David
authors.initials: D
authors.lastname: Verhoeven
authors.forename: Sumathi
authors.initials: S
authors.lastname: Sankaran
authors.forename: Tiffany
authors.initials: T
authors.lastname: Glavan
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Reay
authors.forename: Satya
authors.initials: S
authors.lastname: Dandekar
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D020869:Gene Expression Profiling; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008253:Macaca mulatta; D009061:Mouth Mucosa / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity*
chemical_list: D016207:Cytokines