[Vitamin D receptor gene polymorphisms: no association with low bone mineral density in adolescent idiopathic scoliosis girls].
OBJECTIVE
To investigate the association of vitamin D receptor (VDR) gene polymorphisms with low bone mineral density (BMD) in adolescent idiopathic scoliosis (AIS) girls.


METHODS
Blood samples were obtained from 146 AIS girls and 146 healthy girls. Anthropometric parameters of AIS group including age, body height, weight and Cobb angle were all recorded. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect and analyze VDR gene distributions of AIS group and control group. BMD of the lumbar spine (L(1)-L(4)) and proximal femur were measured using dual energy x-ray absorptiometry in AIS group.


RESULTS
The frequency of Bb genotype was significantly higher in patients than that in controls (P < 0.05). There was no distinction among the lumbar spine and proximal femur BMD of each genotype in AIS group (P > 0.05).


CONCLUSIONS
VDR gene polymorphisms have no association with the low spine lumbar and proximal femur BMD in AIS girls.
Chen
Wen-jun
WJ
Department of Spinal Surgery, the Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Qiu
Yong
Y
Zhu
Feng
F
Zhu
Ze-zhang
ZZ
Sun
Xu
X
Liu
Zhen
Z
Chen
Zhi-jun
ZJ
D000293:Adolescent; D015519:Bone Density / Q000235:genetics*; D002648:Child; D005260:Female; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012600:Scoliosis / Q000235:genetics / Q000503:physiopathology*
D018167:Receptors, Calcitriol