title: Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors.
abstract: Maternal separation is known to induce long-term changes in neuroendocrine and emotional responsiveness to stress in a large variety of models. We examined an animal model of early deprivation in Sprague-Dawley rats consisting of separating litters from their mothers and littermates 3 h daily during postnatal days 2 to 15. In adulthood, maternally deprived rats in comparison with non-deprived controls exhibited an increase in anxiety and depression-related behaviors in the open-field and forced swim tests. Because serotonin (5-HT) 5-HT(1A) receptors seem to play an important role in the pathophysiology of major depression and in the mechanism of action of antidepressants, we investigated if 5-HT(1A) receptor function is altered in deprived rats. Although the hypothermic response to the 5-HT(1A) receptor agonist 8-OH-DPAT was increased in adult deprived rats compared to non-deprived control group, no differences between groups were found in the effect of the systemic 8-OH-DPAT administration on serotoninergic cell firing in dorsal raphe nucleus and in the 5-HT release at the ventral hippocampus levels. These results suggest that 5-HT(1A) receptors are not substantially affected in adult Sprague-Dawley rats that were subjected to a maternal deprivation 3 h daily during the neonatal period.
authors.affiliation: Université de Lyon, F-69008, Lyon, France. laura.lambas-senas@recherche.univ-lyon1.fr
authors.forename: Laura
authors.initials: L
authors.lastname: Lambás-Señas
authors.forename: Ouissame
authors.initials: O
authors.lastname: Mnie-Filali
authors.forename: Véronique
authors.initials: V
authors.lastname: Certin
authors.forename: Céline
authors.initials: C
authors.lastname: Faure
authors.forename: Laetitia
authors.initials: L
authors.lastname: Lemoine
authors.forename: Luc
authors.initials: L
authors.lastname: Zimmer
authors.forename: Nasser
authors.initials: N
authors.lastname: Haddjeri
mesh_terms: D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology; D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001345:Autoradiography; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D003863:Depression / Q000523:psychology*; D004594:Electrophysiology; D006624:Hippocampus / Q000378:metabolism; D007035:Hypothermia / Q000139:chemically induced; D008297:Male; D008426:Maternal Deprivation; D017551:Microdialysis; D009043:Motor Activity / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010879:Piperazines; D011725:Pyridines; D019275:Radiopharmaceuticals; D011903:Raphe Nuclei / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044282:Receptor, Serotonin, 5-HT1A / Q000378:metabolism*; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013550:Swimming / Q000523:psychology
chemical_list: C114151:4-fluoro-N-(2-(1-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-2-pyridinylbenzamide; D010879:Piperazines; D011725:Pyridines; D019275:Radiopharmaceuticals; D017366:Serotonin Receptor Agonists; D044282:Receptor, Serotonin, 5-HT1A; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin