title: A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.
abstract: This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P=0.006, P=0.001 and P=0.002, respectively).
authors.affiliation: Department of Advanced Medical Science, Division of Molecular Diagnostics, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Zhenyan
authors.initials: Z
authors.lastname: Fu
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Sato
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Izumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kasamaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shindo
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ohta
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Soma
authors.forename: Noriko
authors.initials: N
authors.lastname: Aoi
authors.forename: Mikano
authors.initials: M
authors.lastname: Sato
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Yitong
authors.initials: Y
authors.lastname: Ma
authors.forename: Koichi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Doba
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Hinohara
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072470:Cytochrome P450 Family 4; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
chemical_list: D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human