title: DNA gains and losses of chromosome in laryngeal squamous cell carcinoma using comparative genomic hybridization.
abstract: OBJECTIVE
  A larynx squamous cell carcinoma (LSCC) is one of the most common forms of cancer and may exhibit various complex karyotypes.
  
  
  METHODS
  We used comparative genomic hybridization (CGH) to analyze DNA gains and losses in 15 squamous cell carcinomas that consisted of 4 glottic, 10 supraglottic, and 1 transglottic localization samples.
  
  
  RESULTS
  The majority of the chromosomal alterations detected were gains: 3 samples of LSCCs revealed high level amplification, while 6 samples displayed gains in various chromosomal regions (17p, 3p, 4p, 5p, 6q, 8p, 9p, 14q, 18p and Xq). One sample was found to have losses (chromosomes 15q and 22q) and 5 had normal CGH profiles.
  
  
  CONCLUSIONS
  Many of these gained regions (4p, 5p, 8p, 10q, 18q and Xq) were novel sites, which may harbor oncogene(s) that potentially play an important role in squamous cell tumorigenesis and progression at supraglottic localizations.
authors.affiliation: Department of Medical Genetics, School of Medicine, Akdeniz University, TR-07070, Antalya, Turkey. keser@akdeniz.edu.tr
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Keser
authors.forename: Ahter D
authors.initials: AD
authors.lastname: Toraman
authors.forename: Gulay
authors.initials: G
authors.lastname: Ozbilim
authors.forename: Kenan
authors.initials: K
authors.lastname: Guney
authors.forename: Guven
authors.initials: G
authors.lastname: Luleci
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D004273:DNA, Neoplasm / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007621:Karyotyping; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D004273:DNA, Neoplasm