Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features.
An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRalphabeta, CD4, CD8 cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4 lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.
Prigione
Ignazia
I
G.Gaslini Scientific Institute, Genova, Italy. ignaziaprigione@ospedale-gaslini.ge.it
Castagnola
Elio
E
Imberti
Luisa
L
Gambini
Claudio
C
Gradoni
Luigi
L
Dianzani
Umberto
U
Ramenghi
Ugo
U
Giacopelli
Francesca
F
Moretta
Alessandro
A
Moretta
Lorenzo
L
Plebani
Alessandro
A
Fischer
Alain
A
Pistoia
Vito
V
D000293:Adolescent; D000493:Allopurinol / Q000627:therapeutic use; D000666:Amphotericin B / Q000627:therapeutic use; D000982:Antipruritics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007633:Keratins / Q000378:metabolism; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D012008:Recurrence; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications* / Q000276:immunology
D000982:Antipruritics; C068538:liposomal amphotericin B; D000493:Allopurinol; D007633:Keratins; D000666:Amphotericin B