[Therapeutic effect of Tripterygium wilfordii multiglycosides on proteinuria in kidney transplant recipients].
OBJECTIVE
To study the effect of multiglycosides of Tripterygium wilfordii (MTW) for treatment of proteinuria in kidney transplant recipients.


METHODS
Forty-five kidney transplant recipients with proternuria were randomized into 3 groups (n=15) and received full daily dose (1 mg/kg) MTW, half dose (0.5 mg/kg) MTW or no MTW (control) in addition to immunosuppressant therapy. The 24-hour urinary protein (24 h Upro), blood urea nitrogen (BUN), serum creatinine (Scr), dose of ciclosporin and the adverse effects of MTW were recorded.


RESULTS
MTW at both the full dose and half dose significantly reduced the 24 h Upro as compared to exclusive immunosuppressant therapy (P<0.05). The therapeutic dose of ciclosporin in patients with full and half dose of MTW was significantly lower than that in the control group (P<0.05), and the patients receiving full dose MTW showed greater adverse effects than those having half dose MTW (P<0.05).


CONCLUSIONS
MTW can significantly ameliorate proteinuria, reduce the therapeutic dose of ciclosporin and protect the renal function in kidney transplant recipients. While producing similar therapeutic effect to routine full dose, long-term use of half dose MTW may reduce the adverse effect associated with MTW.
Huang
Yun
Y
Department of Nephropathy, Hainan Provincial People's Hospital, Haikou 570311, China. h13976919199@126.com
Long
Tian-biao
TB
Zhan
Feng
F
Pan
Chu-ying
CY
Chen
Dao-jun
DJ
Lin
Shu-dian
SD
D000328:Adult; D000368:Aged; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D029757:Tripterygium / Q000737:chemistry*; D055815:Young Adult
D006027:Glycosides