title: Radiotherapy for perianal Paget's disease: a case report.
abstract: BACKGROUND
  Perianal Paget's disease was first described in 1893. Since then, fewer than 300 cases have been reported in the literature. It might be associated with an underlying malignancy. Most of the patients are treated with surgical excision, which is often mutilating and of variable efficacy. In the present report, we describe the case of an 80-year-old woman with perianal Paget's disease. She was treated at our institution with radiotherapy with curative intent. The pertinent literature is reviewed, and the controversies in diagnosis and management are discussed.
  
  
  CONCLUSIONS
  Our single-case experience supports the opinion that radiotherapy is a viable treatment option with curative potential for patients with perianal Paget's disease. For the treatment of in situ disease, hypofractionated regimens to a total dose of 40-44 Gy and orthovoltage X-ray beams are recommended.
authors.affiliation: Department of Radiotherapy, Institute of Oncology, Ljubljana, Slovenia.
authors.forename: Vaneja
authors.initials: V
authors.lastname: Velenik
authors.forename: Barbara
authors.initials: B
authors.lastname: Segedin
authors.forename: Franc
authors.initials: F
authors.lastname: Anderluh
authors.forename: Irena
authors.initials: I
authors.lastname: Oblak
authors.forename: Primoz
authors.initials: P
authors.lastname: Strojan
mesh_terms: D000369:Aged, 80 and over; D001005:Anus Neoplasms / Q000532:radiotherapy*; D019583:Dose Fractionation, Radiation; D005260:Female; D006801:Humans; D010145:Paget Disease, Extramammary / Q000473:pathology* / Q000532:radiotherapy*; D010502:Perineum / Q000473:pathology* / Q000528:radiation effects