Polyamine as a signaling molecule for controlling an adaptive mutation.
In the absence of exogenous polyamines, the polyamine-deficient Escherichia coli mutant shows not only a characteristic dual-phase growth with abnormal growth, growth arrest, and normal growth after mutation, but also a higher expression of the SOS genes than the polyamine-proficient wild type. The interval of the growth arrest is inversely regulated in a polyamine concentration-dependent manner. These results indicate that the polyamines can act as a signal not only for provoking an adaptive mutation, but also for hastening generation of an adaptive mutation.
Jung
Il Lae
IL
Department of Radiation Biology, Environmental Radiation Research Center, Korean Atomic Energy Research Institute, Yusong, Daejeon, 305-600, Korea.
Kim
In Gyu
IG
D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D011073:Polyamines / Q000378:metabolism*; D013014:SOS Response, Genetics; D015398:Signal Transduction
D029968:Escherichia coli Proteins; D011073:Polyamines