title: [Significance of interleukin-1beta expression and microvascular density in invasive micropapillary carcinoma of breast].
abstract: OBJECTIVE
  To study the significance of interleukin-1beta (IL-1beta) expression and microvascular density (MVD) in invasive micropapillary carcinoma (IMPC) of breast.
  
  
  METHODS
  Immunohistochemical study for IL-1beta and CD34 was performed on 100 cases of IMPC and 97 cases of invasive ductal carcinoma (IDC). The relationship between IL-1beta expression, MVD and various pathologic parameters (estrogen and progesterone receptor status, Ki-67 proliferative index, histologic grade and lymph node metastasis) in IMPC was analyzed.
  
  
  RESULTS
  There was no significant difference in expression of IL-1beta between IMPC and IDC (P = 0.924). The expression of IL-1beta positively correlated with proliferative index (P = 0.023), histologic grade (P = 0.038) and lymph node metastasis (P = 0.008), and negatively correlated with estrogen receptor expression (P = 0.035). The MVD in IMPC was significantly higher than that in IDC (66.4 versus 60.0, P = 0.003). The mean MVD in node-positive IMPC was higher than that in node-negative IMPC (68.8 versus 54.4, P = 0.001). In IMPC, the MVD in histologic grade II and III tumors was much higher than that in histologic grade I tumors (68.3 versus 59.9, P = 0.025). It had no relationship with hormonal receptor status and proliferative index.
  
  
  CONCLUSIONS
  Overexpression of IL-1beta and high microvessel density may have important roles in tumor cell proliferation and lymph node metastasis in IMPC.
authors.affiliation: Department of Breast Pathology, Tianjin Medical University Cancer Hospital, Tianjin 300060, China.
authors.forename: Li-fang
authors.initials: LF
authors.lastname: Cui
authors.forename: Xiao-jing
authors.initials: XJ
authors.lastname: Guo
authors.forename: Jia
authors.initials: J
authors.lastname: Wei
authors.forename: Fang-fang
authors.initials: FF
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Gu
authors.forename: Yu
authors.initials: Y
authors.lastname: Fan
authors.forename: Rong-gang
authors.initials: RG
authors.lastname: Lang
authors.forename: Li
authors.initials: L
authors.lastname: Fu
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002277:Carcinoma / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000378:metabolism*; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000503:physiopathology*
chemical_list: D053583:Interleukin-1beta