Palladium-catalyzed cross coupling reaction of benzyl bromides with diazoesters for stereoselective synthesis of (E)-alpha,beta-diarylacrylates.
A Pd-catalyzed cross-coupling reaction of benzyl bromides with alpha-aryldiazoesters is described, and E-alpha,beta-diarylacrylates were obtained in good yields and excellent E-to-Z selectivity (>20:1).
Yu
Wing-Yiu
WY
Department of Applied Biology and Chemical Technology and Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. bcwyyu@inet.polyu.edu.hk
Tsoi
Yuk-Tai
YT
Zhou
Zhongyuan
Z
Chan
Albert S C
AS
D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000179:Acrylates; D000475:Alkenes; D001391:Azo Compounds; D001593:Benzyl Compounds; C006666:azoester; D010165:Palladium; C038682:benzyl bromide