title: Contributions of biological tumor parameters to the incorporation rate of L: -[methyl-(11)C] methionine into astrocytomas and oligodendrogliomas.
abstract: We compared the tumor uptake of (11)C-methionine (MET) with positron emission tomography (PET) with the results of a pathological analysis to examine the proliferative potential and microvessel density measured with immunostaining for MIB-1 and factor VIII, respectively, from 33 patients with glioma. The MET uptake in oligodendrogliomas was significantly greater than that in grade 2 astrocytomas and comparable to those in grade 3 and 4 astrocytomas. The MIB-1 index of oligodendroglioma meanwhile was comparable to that of grade 2 astrocytoma. The microvessel area in oligodendroglioma was significantly greater than that in grade 2 astrocytomas and comparable to those in grade 3 and 4 astrocytomas. According to a multivariate statistical analysis, MET uptake ratio was closely correlated with the MIB-1 index among astrocytomas. An increase in the microvessel area in the oligodendrogliomas contributed to the higher MET uptake among the tumors with a low-proliferative index. This information is important for interpreting the results of MET-PET studies for clinical use.
authors.affiliation: Department of Neurosurgery, Tokyo Medical and Dental University, Yushima, Bunkyo-ku, Japan.
authors.forename: Takeko
authors.initials: T
authors.lastname: Nojiri
authors.forename: Tadashi
authors.initials: T
authors.lastname: Nariai
authors.forename: Masaru
authors.initials: M
authors.lastname: Aoyagi
authors.forename: Michio
authors.initials: M
authors.lastname: Senda
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishii
authors.forename: Kiichi
authors.initials: K
authors.lastname: Ishiwata
authors.forename: Kikuo
authors.initials: K
authors.lastname: Ohno
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002196:Capillaries / Q000378:metabolism / Q000473:pathology; D002250:Carbon Radioisotopes; D002455:Cell Division; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008715:Methionine / Q000378:metabolism*; D008833:Microcirculation; D008875:Middle Aged; D009367:Neoplasm Staging; D009837:Oligodendroglioma / Q000098:blood supply / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D049268:Positron-Emission Tomography
chemical_list: D002250:Carbon Radioisotopes; D005169:Factor VIII; D008715:Methionine