Integrated actions of progesterone receptor and cell cycle machinery regulate breast cancer cell proliferation.
Multiple laboratories have investigated progesterone receptor (PR) involvement in breast cancer cell cycle progression. There is now a growing body of evidence demonstrating complex interactions between PR and cell cycle regulatory proteins. Here we review the current literature linking PR to cell cycle control and discuss gaps in the current knowledge. A more complete understanding of the relationships between PR and cell cycle regulatory molecules may reveal additional avenues for prevention and treatment of steroid receptor positive breast cancers.
Dressing
Gwen E
GE
Department of Medicine, Division of Hematology, Oncology, and Transplantation, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, United States.
Lange
Carol A
CA
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology*; D002453:Cell Cycle / Q000502:physiology*; D049109:Cell Proliferation; D006801:Humans; D011980:Receptors, Progesterone / Q000378:metabolism*; D015398:Signal Transduction
D011980:Receptors, Progesterone