title: Propofol infusion syndrome in adult cardiac surgery.
abstract: We report a case of rapid and progressive severe metabolic acidosis in the postoperative period after coronary artery bypass grafting. After exclusion of potential causes for this phenomenon, it was attributed to perioperative intravenous propofol infusion causing propofol infusion syndrome. We discontinued this intravenous agent resulting in a prompt and considerable improvement in the lactic acidosis and clinical condition in the subsequent 6 hours resulting in an uneventful recovery and hospital discharge.
authors.affiliation: Department of Cardiothoracic Surgery, John Radcliffe Hospital, Oxford, United Kingdom. driyoob@yahoo.com
authors.forename: Mohammed Iyoob Mohammed
authors.initials: MI
authors.lastname: Ilyas
authors.forename: Lognathen
authors.initials: L
authors.lastname: Balacumaraswami
authors.forename: Christopher
authors.initials: C
authors.lastname: Palin
authors.forename: Chandi
authors.initials: C
authors.lastname: Ratnatunga
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D000368:Aged; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects*; D001774:Blood Chemical Analysis; D002315:Cardiopulmonary Bypass; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000009:adverse effects / Q000379:methods*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D019990:Perioperative Care; D015742:Propofol / Q000008:administration & dosage / Q000009:adverse effects*; D018570:Risk Assessment; D012720:Severity of Illness Index; D013577:Syndrome
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol