title: Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.
authors.affiliation: Department of Chemistry, Oxford University, UK.
authors.forename: Refaat B
authors.initials: RB
authors.lastname: Hamed
authors.forename: Edward T
authors.initials: ET
authors.lastname: Batchelar
authors.forename: Jasmin
authors.initials: J
authors.lastname: Mecinović
authors.forename: Timothy D W
authors.initials: TD
authors.lastname: Claridge
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Schofield
mesh_terms: D000595:Amino Acid Sequence; D004926:Escherichia coli / Q000235:genetics; D008025:Ligases / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D011392:Proline / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D013237:Stereoisomerism; D013302:Streptomyces / Q000201:enzymology*; D013845:Thienamycins / Q000096:biosynthesis* / Q000737:chemistry*
chemical_list: C538864:(2S,5S)-trans-carboxymethylproline; D013845:Thienamycins; D011392:Proline; D008025:Ligases; C015537:thienamycin