Haplotype analysis of the PARK 11 gene, GIGYF2, in sporadic Parkinson's disease.
Familial Parkinsonism (PARK) genes are strong candidates for conferring susceptibility to common forms of PD. However, most studies to date have provided little evidence that their common variants substantially influence disease risk. Recently, mutations were described in the gene, GIGYF2 (TNRC15), located at the PARK11 locus (2q37.1). Here, we use a haplotype tagging approach to examine common variation in the GIGYF2 gene and PD risk. PD cases (n = 568) and age and gender-matched control subjects (n = 568) were recruited from three specialist movement disorder clinics in Brisbane (Australia) and the Australian electoral roll. Twelve tagging SNPs were assessed in all subjects and haplotype and genotype associations were explored. Overall our findings suggest that common genetic variants of GIGYF2 do not significantly affect sporadic PD risk in Australian Caucasians.
Sutherland
Greg T
GT
Eskitis Institute for Cell and Molecular Therapies, School of Biomolecular and Physical Sciences, Griffith University, Brisbane, Queensland, Australia. g.sutherland@griffith.edu.au
Siebert
Gerhard A
GA
Newman
Jeremy R B
JR
Silburn
Peter A
PA
Boyle
Richard S
RS
O'Sullivan
John D
JD
Mellick
George D
GD
D000368:Aged; D002352:Carrier Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
D002352:Carrier Proteins; C478016:GIGYF2 protein, human; D044767:Ubiquitin-Protein Ligases; C111567:parkin protein