title: New furanoditerpenoids from Croton jatrophoides.
abstract: Four furanoditerpenoids were isolated from roots of Croton jatrophoides (Euphorbiaceae) collected in Tanzania. In addition to the known compounds penduliflaworosin and teucvin (mallotucin A), a new teucvin isomer, which was named isoteucvin, and a furanoditerpenoid with a new skeleton, for which the name jatrophoidin was adopted, were isolated. Their structures were elucidated by spectroscopic methods such as ESI-MS and NMR, including (1)H-, (13)C-, and two-dimensional NMR. The crystal structures of isoteucvin and jatrophoidin were solved using single-crystal X-ray diffraction, by which we also established the absolute configuration of jatrophoidin. The refined crystal structure of isoteucvin has the same (absolute) configuration as jatrophoidin, although the X-ray diffraction data of isoteucvin were not conclusive with respect to the absolute configuration.
authors.affiliation: Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
authors.forename: Zakaria H
authors.initials: ZH
authors.lastname: Mbwambo
authors.forename: Kenne
authors.initials: K
authors.lastname: Foubert
authors.forename: Musa
authors.initials: M
authors.lastname: Chacha
authors.forename: Modest C
authors.initials: MC
authors.lastname: Kapingu
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Magadula
authors.forename: Mainen M
authors.initials: MM
authors.lastname: Moshi
authors.forename: Filip
authors.initials: F
authors.lastname: Lemière
authors.forename: Kees
authors.initials: K
authors.lastname: Goubitz
authors.forename: Jan
authors.initials: J
authors.lastname: Fraanje
authors.forename: René
authors.initials: R
authors.lastname: Peschar
authors.forename: Arnold
authors.initials: A
authors.lastname: Vlietinck
authors.forename: Sandra
authors.initials: S
authors.lastname: Apers
authors.forename: Luc
authors.initials: L
authors.lastname: Pieters
mesh_terms: D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D007536:Isomerism; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots; D013636:Tanzania
chemical_list: D004224:Diterpenes; D005663:Furans; D010936:Plant Extracts; C539868:isoteucvin; C539869:jatrophoidin; C539815:penduliflaworosin; C407871:teucvin