[Vascular effects of ginseng compounds].
In the review it has been systematized data on the vascular effects of ginsenosides in vivo. It has been shown that ginsenosides increase a tolerance of isolated arteries to oxidative stress, hypoxia-reoxigenation, homocysteine and other pathogenic factors. It has been performed an analysis published works on the effects of triterpene saponines on the NO synthesis in the isolated endothelial cells, a proliferation of these cells, an apoptosis of endotheliocytes, a secretion of vascular endothelial growth factor by endothelial cells. It was exhibited data on the potency of ginsenosides to inhibit a proliferation of vascular smooth muscle cells. It has been discussed a molecular mechanisms of triterpene saponines action, their interaction with steroid hormone receptors, proteinkinases, NO-synthase, guanilyl cyclase, K(Ca)-channels, Ca(2+)-channels.
Maslov
L N
LN
Lishmanov
Iu B
IuB
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D015220:Calcium Channels / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D042783:Endothelial Cells / Q000378:metabolism*; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology*; D006162:Guanylate Cyclase / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D005894:Panax / Q000737:chemistry; D015221:Potassium Channels / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism
D015220:Calcium Channels; D036145:Ginsenosides; D015221:Potassium Channels; D011987:Receptors, Steroid; D006710:Homocysteine; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D006162:Guanylate Cyclase