title: Development of a stereotactic device for gamma knife irradiation of small animals.
abstract: OBJECTIVE
  The authors developed a stereotactic device for irradiation of small animals with Leksell Gamma Knife(R) Model C. Development and verification procedures were described in this article.
  
  
  METHODS
  The device was designed to satisfy three requirements. The mechanical accuracy in positioning was to be managed within 0.5 mm. The strength of the device and structure were to be compromised to provide enough strength to hold a small animal during irradiation and to interfere the gamma ray beam as little as possible. The device was to be used in combination with the Leksell G-frame(R) and KOPF(R) rat adaptor. The irradiation point was determined by separate imaging sequences such as plain X-ray images.
  
  
  RESULTS
  The absolute dose rate with the device in a Leksell Gamma Knife was 3.7% less than the value calculated from Leksell Gamma Plan(R). The dose distributions measured with GAFCHROMIC(R) MD-55 film corresponded to those of Leksell Gamma Plan(R) within acceptable range. The device was used in a series of rat experiments with a 4 mm helmet of Leksell Gamma Knife.
  
  
  CONCLUSIONS
  A stereotactic device for irradiation of small animals with Leksell Gamma Knife Model C has been developed so that it fulfilled above requirements. Absorbed dose and dose distribution at the center of a Gamma Knife helmet are in acceptable ranges. The device provides enough accuracy for stereotactic irradiation with acceptable practicality.
authors.affiliation: Department of Neurosurgery , Seoul National University, College of Medicine, Seoul, Korea.
authors.forename: Hyun-Tai
authors.initials: HT
authors.lastname: Chung
authors.forename: Young Seob
authors.initials: YS
authors.lastname: Chung
authors.forename: Dong Gyu
authors.initials: DG
authors.lastname: Kim
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.forename: Keun-Tae
authors.initials: KT
authors.lastname: Cho