title: Cytochrome bd confers nitric oxide resistance to Escherichia coli.
abstract: The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.
authors.affiliation: Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
authors.forename: Maria G
authors.initials: MG
authors.lastname: Mason
authors.forename: Mark
authors.initials: M
authors.lastname: Shepherd
authors.forename: Peter
authors.initials: P
authors.lastname: Nicholls
authors.forename: Paul S
authors.initials: PS
authors.lastname: Dobbin
authors.forename: Kathryn S
authors.initials: KS
authors.lastname: Dodsworth
authors.forename: Robert K
authors.initials: RK
authors.lastname: Poole
authors.forename: Chris E
authors.initials: CE
authors.lastname: Cooper
mesh_terms: D003573:Cytochrome b Group; D003580:Cytochromes / Q000378:metabolism*; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*
chemical_list: D003573:Cytochrome b Group; D003580:Cytochromes; D045222:Electron Transport Chain Complex Proteins; D029968:Escherichia coli Proteins; D009569:Nitric Oxide; D010088:Oxidoreductases; C040077:cytochrome bd terminal oxidase complex, E coli