title: Integrative biology--a strategy for systems biomedicine.
abstract: The precision of genome sequences, together with advanced computational approaches, allows complex, clinically relevant biological systems to be examined. Here, I describe the experiences of the Genome Institute of Singapore (GIS) in using genome-to-systems strategies to accelerate biomedical research. To maximize clinically relevant output, we have explored an organizational strategy that encourages coordinated experimentation among investigators with diverse skills and interests through building a culture of integrative science. Our experience suggests that systems biomedicine is a real and potentially fruitful strategy for translational research.
authors.affiliation: Genome Institute of Singapore, 60 Biopolis Street, 02-01 Genome, Singapore. liue@gis.a-star.edu.sg
authors.forename: Edison T
authors.initials: ET
authors.lastname: Liu
mesh_terms: D000818:Animals; D035843:Biomedical Research; D006801:Humans; D012846:Singapore; D049490:Systems Biology / Q000379:methods*; D014158:Transcription, Genetic; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D016159:Tumor Suppressor Protein p53