Recent advances in the methodology, optimisation and application of MEEKC.
MEEKC is an electrodriven separation technique. Oil-in-water microemulsions (MEs) and to a lesser extent water-in-oil MEs have been used in MEEKC as BGEs to achieve separation of a diverse range of solutes. The more common (oil-in-water) MEs are composed of nanometre-sized droplets of oil suspended in an aqueous buffer. Interfacial tension between the oil and aqueous phase is reduced close to zero by the presence of a surfactant and a co-surfactant. MEEKC is capable of providing fast and efficient separations for a wide range of acidic, basic and neutral, water-soluble and -insoluble compounds. This review details the advances in MEEKC-based separations from the period 2006 to 2008. Areas covered include online sample concentration, chiral separation, suppressed electroosmosis MEEKC, MEEKC-MS, and the use of MEEKC in predicting migration behaviour and solute characteristics. A fundamental introduction to MEEKC, along with the presentation and discussion of recent applications is also included.
Ryan
Richie
R
Waterford Institute of Technology, Cork Road Campus, Waterford, Ireland. rjryan@wit.ie
Donegan
Sheila
S
Power
Joe
J
McEvoy
Eamon
E
Altria
Kevin
K
D001688:Biological Products / Q000032:analysis; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000295:instrumentation* / Q000379:methods*; D019075:Electrophoresis, Capillary; D004655:Emulsions / Q000737:chemistry; D013058:Mass Spectrometry; D004364:Pharmaceutical Preparations / Q000032:analysis; D013237:Stereoisomerism
D001688:Biological Products; D004655:Emulsions; D004364:Pharmaceutical Preparations