title: Influence of a single oral dose of vitamin D(2) on serum 25-hydroxyvitamin D concentrations in tuberculosis patients.
abstract: METHODS
  Newham Chest Clinic, London, UK.
  
  
  OBJECTIVE
  To determine the safety and efficacy of the administration of bolus-dose vitamin D(2) in elevating serum 25-hydroxyvitamin D (25[OH]D) concentrations in tuberculosis (TB) patients.
  
  
  METHODS
  A multi-ethnic cohort of TB patients was randomised to receive a single oral dose of 2.5 mg vitamin D(2) (n = 11) or placebo (n = 14). Serum 25(OH)D and corrected calcium concentrations were determined at baseline and 1 week and 8 weeks post-dose, and compared to those of a multi-ethnic cohort of 56 healthy adults receiving an identical dose of vitamin D(2).
  
  
  RESULTS
  Hypovitaminosis D (serum 25[OH]D < 75 nmol/l) was present in all patients at baseline. A single oral dose of 2.5 mg vitamin D2 corrected hypovitaminosis D in all patients in the intervention arm of the study at 1 week post-dose, and induced a 109.5 nmol/l mean increase in their serum 25(OH)D concentration. Hypovitaminosis D recurred in 10/11 patients at 8 weeks post-dose. No patient receiving vitamin D(2) experienced hypercalcaemia. Patients receiving 2.5 mg vitamin D(2) experienced a greater mean increase in serum 25(OH)D at 1 week post-dose than healthy adults receiving 2.5 mg vitamin D(2).
  
  
  CONCLUSIONS
  A single oral dose of 2.5 mg vitamin D(2) corrects hypovitaminosis D at 1 week but not at 8 weeks post-dose in TB patients.
authors.affiliation: Centre for Health Sciences, Barts and The London School of Medicine and Dentistry, London, UK. a.martineau@qmul.ac.uk
authors.forename: A R
authors.initials: AR
authors.lastname: Martineau
authors.forename: A M
authors.initials: AM
authors.lastname: Nanzer
authors.forename: K R
authors.initials: KR
authors.lastname: Satkunam
authors.forename: G E
authors.initials: GE
authors.lastname: Packe
authors.forename: S J
authors.initials: SJ
authors.lastname: Rainbow
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Maunsell
authors.forename: P M
authors.initials: PM
authors.lastname: Timms
authors.forename: T R
authors.initials: TR
authors.lastname: Venton
authors.forename: S M
authors.initials: SM
authors.lastname: Eldridge
authors.forename: R N
authors.initials: RN
authors.lastname: Davidson
authors.forename: R J
authors.initials: RJ
authors.lastname: Wilkinson
authors.forename: C J
authors.initials: CJ
authors.lastname: Griffiths
mesh_terms: D000284:Administration, Oral; D000328:Adult; D004872:Ergocalciferols / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014815:Vitamins / Q000008:administration & dosage*
chemical_list: D004872:Ergocalciferols; D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D