title: [Study on T cell subsets in HIV/AIDS patients].
abstract: OBJECTIVE
  Analyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development.
  
  
  METHODS
  T cell subsets from 15 normal control subjects, 79 HIV/ AIDS patients were detected by FCM.
  
  
  RESULTS
  With diesase progression, CD4+ Naive cell counts and ratio was both decreased obviously (P < 0.001); CD4+ Tcm cell counts was significantly decreased (P < 0.001), CD4+ Tcm cell ratio was obviously higher (P = 0.002); CD4 TEM cell ratio was obviously increased( P < 0.001); CD8+ T Naive cell counts and ratio was also decreased obviously (P < 0.05); CD8+ T(CM), T(EM), T(EMRA) are not significantly different.
  
  
  CONCLUSIONS
  The peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.
authors.affiliation: Beijing You'an Hospital, Capital Medical University, Beijing 100069 China.
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Li
authors.forename: Zhen-Huan
authors.initials: ZH
authors.lastname: Cao
authors.forename: Yun-Xia
authors.initials: YX
authors.lastname: Ji
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Xin-Yue
authors.initials: XY
authors.lastname: Chen
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D000328:Adult; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D006678:HIV / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*