Stable preformed chiral palladium catalysts for the one-pot asymmetric reductive amination of ketones.
The application of air stable preformed [(R)-BINAP]PdBr2, [(S)-BINAP]PdBr2, [(R)-Tol-BINAP]PdBr2, and [(S,S)-CHIRAPHOS]PdBr2 complexes in the one-pot asymmetric reductive amination of various carbonyl compounds, leading to chiral amines in very good yields with high enantioselectivities (<99% ee), is reported.
Rubio-Pérez
Laura
L
Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, 04510, DF, México. laurarpz@correo.unam.mx
Pérez-Flores
F Javier
FJ
Sharma
Pankaj
P
Velasco
Luis
L
Cabrera
Armando
A
D000388:Air; D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D006859:Hydrogen / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000814:Aniline Compounds; D007659:Ketones; D010165:Palladium; D006859:Hydrogen; C023650:aniline