title: Effect of Amblyomma cajennense ticks on the immune response of BALB/c mice and horses.
abstract: This work evaluated the effect of the Amblyomma cajennense tick on the immune response of BALB/c mice and on horse lymph node cell proliferation. We observed that mice do not develop resistance to nymphs of this tick species and that lymphocyte proliferation of this host is inhibited by tick saliva, nymphal extract, or infestations. Horse lymph node cell proliferation is inhibited by tick saliva as well. Mice lymphocytes under the effect of tick saliva, nymphal extract, or infestations display a predominantly Th-2 cytokine production pattern. Observed results partially explain this tick's disease vectoring capacity and broad host range.
authors.affiliation: Universidade Estadual Paulista, Jaboticabal, Brazil.
authors.forename: Karina Carrão
authors.initials: KC
authors.lastname: Castagnolli
authors.forename: Beatriz Rossetti
authors.initials: BR
authors.lastname: Ferreira
authors.forename: Alessandra Mara
authors.initials: AM
authors.lastname: Franzin
authors.forename: Márcio Botelho
authors.initials: MB
authors.lastname: de Castro
authors.forename: Matias Pablo Juan
authors.initials: MP
authors.lastname: Szabó
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D016207:Cytokines / Q000096:biosynthesis; D006736:Horses / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology / Q000378:metabolism; D013987:Ticks / Q000502:physiology*
chemical_list: D016207:Cytokines