Neonatal administration of fluoxetine did not alter the anxiety indicators, but decreased the locomotor activity in adult rats in the elevated plus-maze.
The objective of this study was evaluate the anxiety and locomotor activity (LA) in 52 Wistar adult male rats, being 26 treated with fluoxetine (10 mg/Kg - sc) in the neonatal period. These same rats received foot shock (FS) (1.6-mA - 2-s) in the 90th day. The anxiety and LA were appraised by plus-maze. The time spent in the open arms was used as anxiety index and the LA was measured by number of entries in closed arms (NECA) and the total of entries (TE). T-test was used with p<0.05 and expresses data in mean+/-SEM. There were reductions with the fluoxetine group in the NECA (2.35+/-0.33) and in the TE (3.96+/-0.61) compared to the controls (4.65+/-0.52) and (6.96+/-0.94). The neonatal administration of fluoxetine did not alter the anxiety, but reduced the LA in the animals that received FS.
Ribas
Valdenilson Ribeiro
VR
Departamento de Nutrição, Universidade Federal de Pernambuco, Recife PE, Brasil. ribaspsy@ufpe.br
Aniceto
Helena Karine Rufino
HK
Martins
Hugo André de Lima
HA
Ribas
Ketlin Helenise dos Santos
KH
Guerra-Ribas
Renata de Melo
Rde M
Fraga
Simone do Nascimento
Sdo N
Ribeiro-Ribas
Valéria
V
Vasconcelos
Célia Maria Mendes
CM
Viana
Marcelo Tavares
MT
Manhaes-de-Castro
Raul
R
D000818:Animals; D000831:Animals, Newborn; D001007:Anxiety / Q000188:drug therapy*; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology*
D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors