title: A rare tumoral combination, synchronous lung adenocarcinoma and mantle cell lymphoma of the pleura.
abstract: BACKGROUND
  Coexistence of adenocarcinoma and mantle cell lymphoma in the same or different anatomical sites is extremely rare. We present a case of incidental discovery of primary lung adenocarcinoma and mantle cell lymphoma involving the pleura, during an axillary thoracotomy performed for a benign condition.
  
  
  METHODS
  A 73-year old male underwent bullectomy and apical pleurectomy for persistent pneumothorax. A bulla of the lung apex was resected en bloc with a scar-like lesion of the lung, which was located in proximity with the bulla origin, by a wide wedge resection. Histologic examination of the stripped-off parietal pleura and of the bullectomy specimen revealed the synchronous occurrence of two distinct neoplasms, a lymphoma infiltrating the pleura and a primary, early lung adenocarcinoma. Immunohistochemical and fluorescence in situ hybridization assays were performed. The morphologic, immunophenotypic and genetic findings supported the diagnosis of primary lung adenocarcinoma (papillary subtype) coexisting with a non-Hodgkin, B-cell lineage, mantle cell lymphoma involving both, visceral and parietal pleura and without mediastinal lymph node involvement. The neoplastic lymphoid cells showed the characteristic immunophenotype of mantle cell lymphoma and the translocation t(11;14). The patient received 6 cycles of chemotherapy, while pulmonary function tests precluded further pulmonary parenchyma resection (lobectomy) for his adenocarcinoma. The patient is alive and without clinical and radiological findings of local recurrence or distant relapse from both tumors 14 months later.
  
  
  CONCLUSIONS
  This is the first reported case of a rare tumoral combination involving simultaneously lung and pleura, emphasizing at the incidental discovery of the two coexisting neoplasms during a procedure performed for a benign condition. Any tissue specimen resected during operations performed for non-tumoral conditions should be routinely sent for pathologic examination.
authors.affiliation: Aristotle University of Thessaloniki Medical School, AHEPA University Hospital, Department of Cardio-Thoracic Surgery, Thessaloniki, Greece. Dhbugias@yahoo.gr
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Hatzibougias
authors.forename: Mattheos
authors.initials: M
authors.lastname: Bobos
authors.forename: Georgia
authors.initials: G
authors.lastname: Karayannopoulou
authors.forename: Georgios
authors.initials: G
authors.lastname: Karkavelas
authors.forename: Georgios T
authors.initials: GT
authors.lastname: Karapanagiotidis
authors.forename: Christophoros N
authors.initials: CN
authors.lastname: Foroulis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Kostopoulos
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D000368:Aged; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008175:Lung Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D020522:Lymphoma, Mantle-Cell / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D010997:Pleural Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*