title: [Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction].
abstract: OBJECTIVE
  To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI).
  
  
  METHODS
  MI was induced in male Sprague-Dawley rats by ligating the left coronary artery. Rats randomly received saline, carvedilol (10 mg.kg(-1).d(-1)) or metoprolol (20 mg.kg(-1).d(-1)) beginning at 4 weeks post MI for 8 weeks per gavage. Sham-operated rats serve as control. Collagen perivascular circumferential collagen area (PCVA), peri-coronary circumferential collagen area (VLCA) and interstitial collagen volume fraction (ICVF) as well as myocardial hydroxyproline content were determined after hemodynamic measurements at the study end.
  
  
  RESULTS
  LVEDP were significantly lower and +/- dp/dt significantly higher in carvedilol and metoprolol treated MI rats than that in saline treated MI rats. Myocardial hydroxyproline, PCVA/VLCA ratio and ICVF were significantly reduced in metoprolol, more significantly reduced in carvedilol treated MI rats compared to saline treated MI rats (all P < 0.05).
  
  
  CONCLUSIONS
  Metoprolol and carvedilol could decrease the concentration of hydroxyproline and ICVF in MI rats.
authors.affiliation: Emergency Center, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Sun
authors.forename: Lu-Hua
authors.initials: LH
authors.lastname: Shen
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Guo
authors.forename: Zhi-Zhong
authors.initials: ZZ
authors.lastname: Li
authors.forename: Chao-Shu
authors.initials: CS
authors.lastname: Tang
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D005355:Fibrosis; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D003094:Collagen; D008790:Metoprolol; D006909:Hydroxyproline