title: Central primitive neuroectodermal tumour with ependymal differentiation in a dog.
abstract: A central primitive neuroectodermal tumour (PNET) with ependymal differentiation was identified in an 18-month-old female Australian terrier dog that died following signs of central nervous system disease. A large space-occupying haemorrhagic mass replaced the thalamus and part of the hypothalamus of the brain. Microscopical examination revealed a tumour formed by a compact sheet of small cells that contained ependymal and perivascular pseudorosettes. Immunohistochemically, the neoplastic cells variably expressed glial fibrillary acidic protein, neuron-specific enolase, vimentin and cytokeratin, consistent with divergent differentiation of the tumour. This case is thought to represent the first description of PNET with ependymal differentiation in a dog.
authors.affiliation: Section of Veterinary Pathology, Department of Basic Veterinary Sciences, Finland. sheadley@smu.ky
authors.forename: S A
authors.initials: SA
authors.lastname: Headley
authors.forename: M
authors.initials: M
authors.lastname: Koljonen
authors.forename: L A
authors.initials: LA
authors.lastname: Gomes
authors.forename: A
authors.initials: A
authors.lastname: Sukura
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D002454:Cell Differentiation; D004283:Dog Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D004805:Ependyma / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D010751:Phosphopyruvate Hydratase