title: Dramatic prostate-specific antigen response with activated hemicellulose compound in metastatic castration-resistant prostate cancer.
abstract: Castration-resistant prostate cancer (CRPC) is an incurable disease with limited treatment options. Herbal supplements are unconventional treatments for a variety of diseases. Active hemicellulose compound (AHCC) is a Japanese supplement discovered by hybridizing several mushrooms used in traditional healing for the purpose of maintaining 'super immunity'. We report on a 66-year-old gentleman with CRPC with an excellent serologic response to AHCC. This case hypothesizes that AHCC may have potential activity against CRPC.
authors.affiliation: Division of Hematology/Oncology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Turner
authors.forename: Uzair
authors.initials: U
authors.lastname: Chaudhary
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D000813:Anilides / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001487:Basidiomycota; D003131:Combined Modality Therapy; D019008:Drug Resistance, Neoplasm; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000494:pharmacology; D008159:Lumbar Vertebrae; D008297:Male; D009570:Nitriles / Q000008:administration & dosage / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011134:Polysaccharides / Q000008:administration & dosage / Q000627:therapeutic use*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy*; D011868:Radioisotopes / Q000627:therapeutic use; D012074:Remission Induction; D012493:Samarium / Q000627:therapeutic use; D012651:Self Medication; D013125:Spinal Neoplasms / Q000097:blood / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D014105:Tosyl Compounds / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D010936:Plant Extracts; D011134:Polysaccharides; D011868:Radioisotopes; D014105:Tosyl Compounds; D012493:Samarium; C053541:bicalutamide; D017430:Prostate-Specific Antigen; D016729:Leuprolide; C499366:Active Hexose Correlated Compound