title: SAFEGUI: resampling-based tests of categorical significance in gene expression data made easy.
abstract: CONCLUSIONS
  A large number of websites and applications perform significance testing for gene categories/pathways in microarray data. Many of these packages fail to account for expression correlation between transcripts, with a resultant inflation in Type I error. Array permutation and other resampling-based approaches have been proposed as solutions to this problem. SAFEGUI provides a user-friendly graphical interface for the assessment of categorical significance in microarray studies, while properly accounting for the effects of correlations among genes. SAFEGUI incorporates both permutation and more recently proposed bootstrap algorithms that are demonstrated to be more powerful in detecting differential expression across categories of genes.
  
  
  BACKGROUND
  http://cebc.unc.edu/software/.
authors.affiliation: Department of Environmental Sciences & Engineering, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Gatti
authors.forename: Myroslav
authors.initials: M
authors.lastname: Sypa
authors.forename: Ivan
authors.initials: I
authors.lastname: Rusyn
authors.forename: Fred A
authors.initials: FA
authors.lastname: Wright
authors.forename: William T
authors.initials: WT
authors.lastname: Barry
mesh_terms: D000465:Algorithms; D019295:Computational Biology; D003196:Computer Graphics; D020869:Gene Expression Profiling / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012984:Software; D014584:User-Computer Interface