[The relationship between dyslipemia and the polymorphism of angiotensin II type 1 receptor gene in hypertensive Kazakans of Xinjiang.].
OBJECTIVE
To investigate the relationship between dyslipidemia and the polymorphism of angiotensin II type 1 receptor (AT(1)R) gene A1166C in hypertensive Kazakans of Xinjiang area.


METHODS
Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the A1166C polymorphism of AT(1)R gene of 296 hypertensive and 198 normotensive Kazakans. Biochemical parameters were measured by autochemical emalyzer.


RESULTS
(1) The TC and LDL-C levels are significantly higher in hypertension group than those in normotensive controls [TC: (4.91 +/- 1.19) mmol/L vs. (4.43 +/- 1.20) mmol/L; LDL-C: (3.36 +/- 1.01) mmol/L vs. (2.94 +/- 1.30) mmol/L, P < 0.001). (2) In hypertension group, TC and LDL-C are related to A1166C polymorphism of AT(1)R gene and TC and LDL-C of AC carriers are significantly higher than AA carriers (P < 0.05).


CONCLUSIONS
The dyslipidemia is related to A1166C polymorphism of AT(1)R gene in hypertensive Kazakans.
Li
Tao
T
Hypertension Institute of Xinjiang, Hypertension Unit of The People's Hospital of Xinjiang Uygur Autonomous Region, Urumuqi 830001, China.
Li
Nan-Fang
NF
Zhou
Ling
L
Wang
Xin-Ling
XL
Zu
Fei-Ya
FY
Wang
Jun
J
Zhang
De-Lian
DL
Zhou
Ke-Ming
KM
D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics
D044140:Receptor, Angiotensin, Type 1