title: [Quantitative evaluation of ischemic myocardium by adenosine tissue Doppler stress echocardiography.].
abstract: OBJECTIVE
  To evaluate the value of adenosine tissue Doppler stress echocardiography on ischemic myocardium.
  
  
  METHODS
  Routine dosage (140 microgxkg(-1)xmin(-1) IV for 6 min) adenosine stress echocardiography was performed on 40 patients with chest pain for diagnosis of coronary artery disease (CAD). The images of left ventricular myocardial motion were acquired by tissue Doppler imaging (TDI) based on traditional 2D stress echocardiography before and 3 min, 6 min after adenosine stress (GE Vivid 7, USA). The myocardial velocity, strain and strain rate in 16 segments were offline measured and analyzed on ECHOPAC software. The results were compared with that of coronary angiography (CAG).
  
  
  RESULTS
  CAG identified 18 CAD and 22 non-CAD patients with 159 ischemic segments and 465 non-ischemic segments. Adenosine significantly increased the systolic velocity (Sm), early diastolic velocity (Em), late diastolic velocity (Am), peak systolic strain (Smax), systolic strain rate (SRs), early diastolic strain rate (SRe) and late diastolic strain rate (SRa) both ischemic and non-ischemic segments (all P < 0.05). The baseline Sm and Em in ischemic segments were significant lower than non-ischemic segments [(3.16 +/- 1.20) cm/s vs (4.03 +/- 1.27) cm/s, P < 0.01; (3.75 +/- 1.67) cm/s vs (4.66 +/- 1.70) cm/s, P < 0.05]. At peak stress the differences in Sm and Em were more significant [(3.98 +/- 1.63) cm/s vs (5.07 +/- 1.52) cm/s; (4.51 +/- 2.32) cm/s vs (6.52 +/- 2.56) cm/s; P < 0.01]. The reductions on Smax and Se were more significant in ischemic segments compared those in non-ischemic segments (16.91% +/- 3.35% vs 19.56% +/- 5.47%, P < 0.01 and 9.53% +/- 2.89% vs 13.06% +/- 4.63%, P < 0.001). The biggest area under curve (AUC) in peak stress was seen in Se by ROC curve analysis (AUC = 0.740, with sensitivity 67% and specificity 83%).
  
  
  CONCLUSIONS
  Parameters derived from TDI offer reliable and accurate information on ischemic myocardium during adenosine stress echocardiography.
authors.affiliation: Department of Cardiology, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China. Email: sunyinguang@yahoo.com.
authors.forename: Yin-Guang
authors.initials: YG
authors.lastname: Sun
authors.forename: Qin-Hua
authors.initials: QH
authors.lastname: Zhao
authors.forename: Ru-Min
authors.initials: RM
authors.lastname: He
authors.forename: Wei-Feng
authors.initials: WF
authors.lastname: Shen
mesh_terms: D000241:Adenosine; D003971:Diastole; D015150:Echocardiography, Doppler; D025401:Echocardiography, Stress; D006801:Humans; D009206:Myocardium
chemical_list: D000241:Adenosine