title: Synthesis of Substituted 2-phenylhistamines via a Microwave Promoted Suzuki Coupling.
abstract: Substitutions on the 2-position of the imidizole ring of histamine have proven useful in a number of biochemical settings. Current art for the synthesis of these constructs relies upon a cumbersome and low-yielding condensation reaction. Here-in we report a new procedure for the synthesis of a series of substituted 2-phenylhistamines utilizing a microwave-promoted Suzuki coupling.
authors.affiliation: NIH Chemical Genomics Center, National Human Genome Research Institute, NIH 9800 Medical Center Drive, MSC 3370 Bethesda, MD 20892-3370 USA.
authors.forename: Amanda P
authors.initials: AP
authors.lastname: Skoumbourdis
authors.forename: Susanna
authors.initials: S
authors.lastname: Moore
authors.forename: Marc
authors.initials: M
authors.lastname: Landsman
authors.forename: Craig J
authors.initials: CJ
authors.lastname: Thomas