title: Flinderoles A-C: antimalarial bis-indole alkaloids from Flindersia species.
abstract: With the aim of finding new natural product antimalarials, the novel indole alkaloids flinderole A-C were found to have selective antimalarial activities with IC(50) values between 0.15-1.42 microM. Flinderole A was isolated from the Australian plant Flindersia acuminata and flinderoles B and C from the Papua New Guinean plant F. amboinensis. Flinderoles A-C contain an unprecedented rearranged skeleton compared to their related isomers of the borreverine class of compounds.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, QLD 4111 Australia.
authors.forename: Liza S
authors.initials: LS
authors.lastname: Fernandez
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Buchanan
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Carroll
authors.forename: Yun Jiang
authors.initials: YJ
authors.lastname: Feng
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Quinn
authors.forename: Vicky M
authors.initials: VM
authors.lastname: Avery
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D010271:Parasites / Q000187:drug effects / Q000254:growth & development; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000962:Antimalarials; D026121:Indole Alkaloids; C538846:flinderole A; C538847:flinderole B; C538848:flinderole C