title: Two cases of methicillin-resistant Staphylococcus aureus keratitis after Epi-LASIK.
abstract: BACKGROUND
  We describe two severe cases of methicillin-resistant Staphylococcus aureus (MRSA) keratitis following Epi-LASIK surgery.
  
  
  METHODS
  One patient was a 23-year-old man who underwent Epi-LASIK surgery in both eyes. He developed an infectious corneal ulcer in one eye 2 days after surgery and was referred to us 7 days post-surgery with corneal perforation, for which we performed therapeutic penetrating keratoplasty. The other patient was a 32-year-old man who developed infectious keratitis in one eye 4 days after bilateral Epi-LASIK and was referred to us 2 days later.
  
  
  METHODS
  Microbial testing revealed MRSA infection as the cause of the keratitis in both patients which was successfully treated with vancomycin eyedrops.
  
  
  CONCLUSIONS
  Infectious keratitis after refractive surgery is uncommon; it is important to diagnose this condition, identify the causative agent, and initiate treatment with appropriate antibiotics as soon as possible.
authors.affiliation: Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan. no-mi@yamaguchi-u.ac.jp.
authors.forename: Norimasa
authors.initials: N
authors.lastname: Nomi
authors.affiliation: Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Morishige
authors.affiliation: Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yamada
authors.affiliation: Department of Ocular Pathophysiology, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Tai-Ichiro
authors.initials: TI
authors.lastname: Chikama
authors.affiliation: Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan.
authors.forename: Teruo
authors.initials: T
authors.lastname: Nishida
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D007634:Keratitis / Q000382:microbiology* / Q000473:pathology; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects* / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D008911:Minocycline / Q000008:administration & dosage; D009883:Ophthalmic Solutions; D013203:Staphylococcal Infections / Q000209:etiology*; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D014640:Vancomycin; D008911:Minocycline