title: "Pathogeno-proteomics".
abstract: Many scientists working on pathogens (viruses, bacteria, fungi, parasites) are betting heavily on data generated by longitudinal genomic-transcriptomic-proteomic studies to explain biochemical host-vector-pathogen interactions and thus to contribute to disease control. Availability of genome sequences of various organisms, from viruses to complex metazoans, led to the discovery of the functions of the genes themselves. The postgenomic era stimulated the development of proteomic and bioinformatics tools to identify the locations, functions, and interactions of the gene products in tissues and/or cells of living organisms. Because of the diversity of available methods and the level of integration they promote, proteomics tools are potentially able to resolve interesting issues specific not only to host-vector-pathogen interactions in cell immunobiology, but also to ecology and evolution, population biology, and adaptive processes. These new analytical tools, as all new tools, contain pitfalls directly related to experimental design, statistical treatment, and protein identification. Nevertheless, they offer the potency of building large protein-protein interaction networks for in silico analysis of novel biological entities named "interactomes," a way of modeling host-vector-pathogen interactions to define new interference strategies.
authors.affiliation: CIRAD UMR 17 [UMR 177 IRD-CIRAD], Montpellier, France. philippe.holzmuller@cirad.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Holzmuller
authors.forename: Pascal
authors.initials: P
authors.lastname: Grébaut
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Brizard
authors.forename: David
authors.initials: D
authors.lastname: Berthier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Chantal
authors.forename: Géraldine
authors.initials: G
authors.lastname: Bossard
authors.forename: Bruno
authors.initials: B
authors.lastname: Bucheton
authors.forename: Frederic
authors.initials: F
authors.lastname: Vezilier
authors.forename: Paul
authors.initials: P
authors.lastname: Chuchana
authors.forename: Rachel
authors.initials: R
authors.lastname: Bras-Gonçalves
authors.forename: Jean-Loup
authors.initials: JL
authors.lastname: Lemesre
authors.forename: Philippe
authors.initials: P
authors.lastname: Vincendeau
authors.forename: Gérard
authors.initials: G
authors.lastname: Cuny
authors.forename: Roger
authors.initials: R
authors.lastname: Frutos
authors.forename: David G
authors.initials: DG
authors.lastname: Biron
mesh_terms: D019295:Computational Biology; D040901:Proteomics