Efficacy of combination of N-acetylcysteine, gentamicin, and amphotericin B for prevention of microbial colonization of ventricular assist devices.
We assessed the in vitro antimicrobial activity and the in vivo efficacy of dipping ventricular assist devices in a combination of N-acetylcysteine, gentamicin, and amphotericin B (NAC/G/A). Ventricular assist devices dipped in NAC/G/A exhibited broad-spectrum antimicrobial activity in vitro and were less likely than undipped devices to become colonized with Staphylococcus aureus in a rabbit model.
Hernandez
Maria D
MD
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA.
Mansouri
Mohammad D
MD
Aslam
Saima
S
Zeluff
Barry
B
Darouiche
Rabih O
RO
D000111:Acetylcysteine / Q000494:pharmacology; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D020099:Coated Materials, Biocompatible; D004195:Disease Models, Animal; D004866:Equipment Contamination / Q000517:prevention & control*; D005839:Gentamicins / Q000494:pharmacology; D006353:Heart-Assist Devices / Q000382:microbiology*; D006801:Humans; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control; D011817:Rabbits; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development*
D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D005839:Gentamicins; D000666:Amphotericin B; D000111:Acetylcysteine