Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic Acid in rats.
We evaluated possible therapeutic effect of multipotent mesenchymal stromal cells from human adipose tissue differentiated to neuronal phenotype with retinoic acid on Wistar rats subjected to toxic effect of 3-nitropropionic acid. Transplantation of mesenchymal stromal cells from human adipose tissue considerably decreased neurological symptoms, normalized exploratory activity (open field test) and long-term memory (Morris test), which correlated with normalization of pathomorphological manifestations in the brain. Destructive changes in the caudate nucleus caused by treatment with 3-nitropropionic acid (reduced size of neurons, changes in their shape, and cell edema) tended to decrease under the effect of multipotent mesenchymal stromal cells: the area of neurons increased 2-fold, the cells acquired typical round shape, cell edema decreased.
Kulikov
A V
AV
Research Center of Neurology, Russian Academy of Medical Sciences, Russia.
Stepanova
M S
MS
Stvolinsky
S L
SL
Hudoerkov
R M
RM
Voronkov
D N
DN
Rzhaninova
A A
AA
Goldstein
D V
DV
Boldyrev
A A
AA
D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary; D059630:Mesenchymal Stem Cells / Q000166:cytology; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000628:therapy*; D009474:Neurons / Q000502:physiology; D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000166:cytology / Q000637:transplantation*
D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; C015392:3-nitropropionic acid