Development of pH-responsive core-shell nanocarriers for delivery of therapeutic and diagnostic agents.
In this paper new dendritic core-shell architectures with pH-labile linkers based on hyperbranched polyglycerol cores and biocompatible poly(ethylene glycol) shells were synthesized which encapsulate the anticancer agent doxorubicin and a dye for near-infrared imaging, an indotricarbocyanine. Acid-sensitive properties of the new nanocarriers and in vitro cytotoxicity of the doxorubicin-nanocarrier are presented as well as preliminary data regarding their toxicity and tumor targeting potential in nude mice.
Xu
Shangjie
S
Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany.
Luo
Ying
Y
Graeser
Ralph
R
Warnecke
André
A
Kratz
Felix
F
Hauff
Peter
P
Licha
Kai
K
Haag
Rainer
R
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D002232:Carbocyanines / Q000008:administration & dosage / Q000737:chemistry*; D003713:Dendritic Cells / Q000378:metabolism*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D005260:Female; D005990:Glycerol / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000737:chemistry
D000970:Antineoplastic Agents; D001672:Biocompatible Materials; D002232:Carbocyanines; D004337:Drug Carriers; D011108:Polymers; C501744:indotricarbocyanine; C043941:polyglycerol; D004317:Doxorubicin; D005990:Glycerol