Functional brain mapping at 9.4T using a new MRI-compatible electrode chronically implanted in rats.
There is a need for acute and chronic stimulation of the brain within the MRI for studies of epilepsy, as well as deep brain stimulation for movement and behavioral disorders. This work describes the production and characteristics of carbon fiber-based electrodes for acute and chronic stimulation in the brain. Increasing MRI field strengths are making it increasingly difficult to introduce foreign objects without a susceptibility artifact. We describe the production of, and the characteristics of carbon fiber-based electrodes. These are biocompatible and can be implanted for chronic studies. We show the use of these electrodes at 9.4T for studying functional activation. Data are presented showing regional connectivity. Activation not only occurs near the electrode, but at sites distant and often contralateral to the electrode. In addition, there were sites showing strong negative activation to stimulation both with direct stimulation and during a kindling-associated seizure.
Dunn
Jeff F
JF
Experimental Imaging Centre, Department of Radiology, Hotchkiss Brain Institute, University of Calgary, Alberta, Canada. dunnj@ucalgary.ca
Tuor
Ursula I
UI
Kmech
Jonn
J
Young
Nicole A
NA
Henderson
Amy K
AK
Jackson
Jesse C
JC
Valentine
Pamela A
PA
Teskey
G Campbell
GC
D000818:Animals; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D004567:Electrodes, Implanted; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D018670:Monitoring, Ambulatory / Q000295:instrumentation* / Q000379:methods; D051381:Rats; D020318:Rats, Long-Evans