title: Selenium intoxication with selenite broth resulting in acute renal failure and severe gastritis.
abstract: Selenium (Se) is an essential trace element in human and animal nutrition. It is also widely utilized in industrial processes. Reports of acute selenium toxicity in humans are rare. We report a case of a 23-year-old female who consumed about 100 mL of liquid selenite broth and presented with severe nausea, vomiting, abdominal pain, hematemesis and acute renal failure (ARF). The serum selenium level was significantly increased. Gastro-duodenoscopy revealed severe corrosive gastritis. Renal biopsy showed features of acute tubular necrosis (ATN), affecting primarily the proximal tubules. The patient was managed with gastric lavage, blood transfusions, infusion of fresh frozen plasma (FFP) and platelet concentrates and hemo-dialysis. The patient was discharged five weeks after admission and her renal functions recovered completely by eight weeks after admission. She continues to be on regular follow-up for any possible sequelae of mucosal corrosive damage. This case highlights a case of selenium intoxication from selenite broth resulting in ARF and corrosive gastritis. The recovery was complete.
authors.affiliation: Department of Nephrology, Royal Hospital, Muscat, Oman. nabmoh@omantel.net.om
authors.forename: P
authors.initials: P
authors.lastname: Kamble
authors.forename: N
authors.initials: N
authors.lastname: Mohsin
authors.forename: A
authors.initials: A
authors.lastname: Jha
authors.forename: A
authors.initials: A
authors.lastname: Date
authors.forename: A
authors.initials: A
authors.lastname: Upadhaya
authors.forename: E
authors.initials: E
authors.lastname: Mohammad
authors.forename: M
authors.initials: M
authors.lastname: Khalil
authors.forename: A
authors.initials: A
authors.lastname: Pakkyara
authors.forename: M
authors.initials: M
authors.lastname: Budruddin
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D001803:Blood Transfusion; D005260:Female; D005756:Gastritis / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D006435:Renal Dialysis; D012643:Selenium / Q000097:blood / Q000506:poisoning*; D018038:Sodium Selenite / Q000506:poisoning; D055815:Young Adult
chemical_list: D012643:Selenium; D018038:Sodium Selenite