Pharyngeal colonization by Kingella kingae in children with invasive disease.
Kingella kingae organisms isolated from the blood of 3 children with invasive infections were identical by pulsed field gel electrophoresis and random amplified polymorphic DNA-polymerase chain reaction analysis to those recovered from the patients' pharynx, demonstrating the likely role of upper respiratory tract colonization in the pathogenesis of the disease caused by this bacterium.
Yagupsky
Pablo
P
Soroka University Medical Center, Ben-Gurion University of the Negev, Negev, Beer-Sheva, USA. yagupsky@bgu.ac.il
Porat
Nurith
N
Pinco
Erica
E
D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002506:Cephalexin / Q000627:therapeutic use; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007223:Infant; D017882:Kingella kingae / Q000235:genetics / Q000302:isolation & purification*; D008297:Male; D016870:Neisseriaceae Infections / Q000188:drug therapy / Q000382:microbiology*; D010614:Pharynx / Q000382:microbiology*; D019105:Random Amplified Polymorphic DNA Technique
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D002506:Cephalexin