title: Eliminating heterophilic antibody interference for ferritin detection using Olympus F(ab')2 based reagent.
abstract: Interferences with the Olympus immunoturbidimetric assay for ferritin have been reported because the antibodies used in the immunoassay are derived from rabbits. Rabbits are familiar pets known to be a risk factor for developing heterophilic (or interfering) antibodies. This report shows how the current Olympus Ferritin assay has been improved to eliminate the interference from heterophilic antibodies.
authors.affiliation: Laboratoires Meditest SA, 1800, Vevey, Switzerland. eric.grouzmann@meditest.ch
authors.forename: Eric
authors.initials: E
authors.lastname: Grouzmann
authors.forename: Nicole
authors.initials: N
authors.lastname: Dayer
authors.forename: Catherine
authors.initials: C
authors.lastname: Bain
authors.forename: Claire M
authors.initials: CM
authors.lastname: Neville
authors.forename: Matthew D
authors.initials: MD
authors.lastname: McCusker
authors.forename: Robert Y
authors.initials: RY
authors.lastname: Wang
mesh_terms: D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology*; D000918:Antibody Specificity; D005189:False Positive Reactions; D005293:Ferritins / Q000097:blood* / Q000276:immunology; D006801:Humans; D007118:Immunoassay / Q000295:instrumentation / Q000379:methods*; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation / Q000379:methods; D011817:Rabbits; D012680:Sensitivity and Specificity
chemical_list: D000910:Antibodies, Heterophile; D007140:Immunoglobulin Fab Fragments; D005293:Ferritins