title: Prospective study of long-term results and prognostic factors after conservative surgery for small bowel Crohn's disease.
abstract: OBJECTIVE
  Several bowel-sparing techniques have been proposed for treating patients with CD, but there have been no prospective studies analyzing risk factors and long-term outcome. We prospectively evaluated safety and long-term efficacy of conservative surgery for patients with complicated CD.
  
  
  METHODS
  From 1993-2007, 393 of 502 consecutive patients underwent surgery for complicated CD of the small bowel. Those with colonic involvement were excluded. The Student t test, chi(2) test, Kaplan-Meier estimates, and Cox proportional hazard model were used to analyze postoperative complications and long-term outcome.
  
  
  RESULTS
  A total of 865 jejunoileal segments underwent 318 small bowel resections and 367 strictureplasties (either classic or nonconventional). There were no deaths; the complication rate was 5.6%, and the cumulative 10-year recurrence rate was 35%. None of the prognostic factors were correlated with postoperative complications. Younger age, an upper jejunoileal location, stricturing behavior, and small-bowel wall thickening 12 months after surgery showed hazard ratios of 2.4 (95% confidence interval [CI], 1-5.4; P = .03), 2.5 (95% CI, 1.3-4.7; P = .004), 2.2 (95% CI, 1.1-4.1; P = .01), and 4.5 (95% CI, 2.3-8.6; P = .000), respectively. Immunomodulator therapy failed to reduce long-term surgical recurrence.
  
  
  CONCLUSIONS
  Young patients with extended and stricturing disease are at high risk for disease recurrence after surgery. Bowel wall thickening was a reliable prognostic factor for these patients. Conservative surgery is safe and effective in treating patients with jejunoileal CD and should be considered as the first-line surgical treatment, preventing the risk of short bowel syndrome caused by repeated resections.
authors.affiliation: Department of Surgery, Gastroenterology and Oncology, II Division of Surgery, Luigi Sacco University Hospital, Milano, Italy. Gianluca.Sampietro@unimi.it
authors.forename: Gianluca M
authors.initials: GM
authors.lastname: Sampietro
authors.forename: Fabio
authors.initials: F
authors.lastname: Corsi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Maconi
authors.forename: Sandro
authors.initials: S
authors.lastname: Ardizzone
authors.forename: Alice
authors.initials: A
authors.lastname: Frontali
authors.forename: Alberto
authors.initials: A
authors.lastname: Corona
authors.forename: Gabriele Bianchi
authors.initials: GB
authors.lastname: Porro
authors.forename: Diego
authors.initials: D
authors.lastname: Foschi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003424:Crohn Disease / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D011446:Prospective Studies; D012008:Recurrence; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult