A case of acute toxic hepatitis after suicidal chloroform and dichloromethane ingestion.
Chloroform and dichloromethane are halogenated hydrocarbons that have been used as a potent anesthetic agent or a general industrial solvent. Short-term exposure to chloroform anesthesia and long-term exposure to chloroform and dichloromethane in workplaces can produce adverse health effects, such as hepatitis, cardiac arrhythmia, and carbon monoxide intoxication. Most of the related reports, however, involve the inhalation of such substances by humans. Limited reports are available regarding the adverse clinical effects of these substances in the case of a person's immediate ingestion of them. A 23-year-old man with an altered mental status after attempting suicide through the oral ingestion of unknown chemicals was brought to the emergency department (ED). We identified that the patient was poisoned with chloroform and dichloromethane by analysis of contents of the suspected chemicals in the bottle through gas chromatography. Abnormal liver enzymes were noted on postingestion day 2, and jaundice occurred on postingestion day 3. The radiologic findings from computed tomographic (CT) scanning showed severe fatty infiltration of the liver parenchyma. The patient received supportive cares and was restored to health from hepatic dysfunction and was discharged without complications after 2 weeks of admission.
Kim
Hoon
H
Department of Emergency Medicine, College of Medicine, Chungbuk National University, Chungbuk 361-763, South Korea. nichekh2000@chungbuk.ac.kr
D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000503:physiopathology* / Q000628:therapy; D002725:Chloroform / Q000506:poisoning*; D006801:Humans; D008297:Male; D008752:Methylene Chloride / Q000506:poisoning*; D012997:Solvents / Q000506:poisoning*; D013406:Suicide, Attempted; D055815:Young Adult
D012997:Solvents; D008752:Methylene Chloride; D002725:Chloroform