title: Multiple cardiac thrombi and thromboembolism in a heparin-induced thrombocytopenia antibody-positive patient with heart failure.
abstract: A 49-year-old Japanese man presented with orthopnea and edema in both legs. He was diagnosed with congestive heart failure with triple-vessel coronary artery disease. Low antithrombin and left ventricular systolic dysfunction were possible causes of his hypercoagulable state. Echocardiography revealed thrombi in the left ventricle and left trium, poor left ventricular contractility, and a normal mitral valve. Electrocardiogram revealed normal sinus rhythm. We found small infarctions of the brain and spleen in the computed tomography. The heparin treatment of cardiac thrombi is useless because the patient had heparin-induced thrombocytopenia antibody. We removed thrombi in the left ventricle and left atrium by thrombectomy and performed coronary artery bypass graft. Warfarin was administered for anticoagulation. He recovered completely and is now doing well. Our experience indicates that poor cardiac function can together cause multiple cardiac thrombi and subsequent thromboembolism without mitral stenosis or atrial fibrillation.
authors.affiliation: Department of Internal Medicine and Cardiology in Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Japan. wake123aha@yahoo.co.jp
authors.forename: Ryotaro
authors.initials: R
authors.lastname: Wake
authors.forename: Takashi
authors.initials: T
authors.lastname: Muro
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hozumi
authors.forename: Ryo
authors.initials: R
authors.lastname: Matsumoto
authors.forename: Toru
authors.initials: T
authors.lastname: Kataoka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Masahiko
authors.initials: M
authors.lastname: Takagi
authors.forename: Shigefumi
authors.initials: S
authors.lastname: Suehiro
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshiyama
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000150:complications* / Q000601:surgery; D004562:Electrocardiography; D006333:Heart Failure / Q000150:complications*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017131:Thrombectomy; D013921:Thrombocytopenia / Q000150:complications*; D013923:Thromboembolism / Q000150:complications* / Q000601:surgery
chemical_list: D000925:Anticoagulants; D006493:Heparin