Peripheral blood CD5-positive B lymphocytes (B-1a cells) after allogeneic stem cell transplantation for acute myeloid leukaemia in humans.
BACKGROUND
Only few data are available in literature regarding the reconstitution of B- 1a cells after allogeneic bone marrow transplantation performed for haematological malignancies.


METHODS
In this study we used flow cytometry to assess the reconstitution of the peripheral blood B-1a cell compartment after allogeneic peripheral blood stem cell transplantation. Cytometric analyses were performed over time on 11 consecutive patients undergoing allogeneic peripheral blood stem cell transplantation for acute myeloid leukaemia in our Haematology Unit and the results were compared with available data regarding B- 1a cell reconstitution after allogeneic bone marrow stem cell transplantation.


RESULTS
In spite of an earlier recovery of B-1a cells in the peripheral blood after allogeneic bone marrow transplantation, the reconstitution of this B-cell subset was similar, regardless of the source of stem cells employed.


CONCLUSIONS
Further studies are necessary in order to clarify the origin of B-1a cells in humans in health and illness.
Veneri
Dino
D
Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Università di Verona, Italy. dino.veneri@univr.it
Franchini
Massimo
M
de Sabata
Donata
D
Ledro
Silvia
S
Vella
Antonio
A
Ortolani
Riccardo
R
Pizzolo
Giovanni
G
Benedetti
Fabio
F
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000276:immunology; D018956:CD5 Antigens / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous / Q000276:immunology; D055815:Young Adult
D018956:CD5 Antigens