Quantitative alterations of CD8+ T cells in juvenile idiopathic arthritis patients in remission.
The study was aimed to investigate whether quantities of CD8(+) T cell subsets are normal in juvenile idiopathic arthritis (JIA) patients with disease remission compared to age-matched healthy donors (HD) and whether chronological age may have an impact on proportions of naive CD8(+) T cells. CD8(+) T cell subsets were analyzed in 17 JIA patients and 32 age-matched HD by flow cytometry. JIA patients showed lower CD3(+)CD8(+) T cells compared to HD. Total counts of CD8(+)CD28(+) and CD8(+)CD28(+)CD45RA(+) T cells were inversely correlated to chronological age in JIA patients and HD. In JIA patients, percentages of CD8(+)CD28(+)CD45RA(+) T cells and of CD62L-expressing CD8(+)CD28(+)CD45RA(+) T cells showed a negative correlation with age. The trend to lower CD28(+)CD45RA(+) T cell proportions in aged JIA patients in remission may reflect a disturbed T cell homeostasis independently of disease activity and may be due to an intrinsic effect in reconstitution of the peripheral T cells.
Prelog
Martina
M
Department of Pediatrics, Pediatrics I, Medical University Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria. Martina.Prelog@i-med.ac.at
Schwarzenbrunner
Nora
N
Tengg
Elisabeth
E
Sailer-Höck
Michaela
M
Kern
Hannelore
H
Zimmerhackl
Lothar Bernd
LB
Brunner
Juergen
J
D000293:Adolescent; D000367:Age Factors; D001171:Arthritis, Juvenile / Q000097:blood* / Q000473:pathology / Q000628:therapy*; D018106:CD28 Antigens / Q000096:biosynthesis; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D019041:L-Selectin / Q000096:biosynthesis; D017493:Leukocyte Common Antigens / Q000096:biosynthesis; D016131:Lymphocyte Subsets; D008297:Male; D012074:Remission Induction; D016896:Treatment Outcome
D018106:CD28 Antigens; D019041:L-Selectin; D017493:Leukocyte Common Antigens