BRCA1, hormone, and tissue-specific tumor suppression.
Germline mutations of BRCA1 predispose women to breast and ovarian cancers. Elucidating molecular mechanism of tissue- and gender-specific phenomena in BRCA1-related tumors is a key to our understanding of BRCA1 function in tumor suppression. This review summarizes studies in recent years on the link between BRCA1 and estrogen/progesterone signaling pathways, as well as discusses various models underscoring a triangle relationship among BRCA1, estrogen and genome instability.
Hu
Yanfen
Y
Department of Molecular Medicine/Institute of Biotechnology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78245, USA. huy3@uthscsa.edu
D019313:BRCA1 Protein / Q000235:genetics*; D001943:Breast Neoplasms / Q000235:genetics*; D049109:Cell Proliferation; D004967:Estrogens / Q000096:biosynthesis / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D042822:Genomic Instability / Q000235:genetics*; D018095:Germ-Line Mutation / Q000235:genetics; D006801:Humans; D011374:Progesterone / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D019313:BRCA1 Protein; C492913:BRCA1 protein, human; D004967:Estrogens; D011374:Progesterone