title: [Advantages of corticosteroids in managing acute bacterial postoperative endophthalmitis].
abstract: Most studies show a trend toward a beneficial or at least neutral effect of associating corticosteroids and antibiotics. However, caution must be taken, with various factors considered: the type, virulence, and size of the inoculum, and the treatment chosen. Early intravitreal administration of 400 microg of dexamethasone seems to be beneficial in treating postoperative Staphylococcus epidermidis-related endophthalmitis. However, a large-scale prospective, randomized, controlled study is mandatory to gain evidence supporting steroid therapy in postoperative endophthalmitis.
authors.affiliation: Service d'Ophtalmologie, Nouvel Hôpital Civil, Hôpitaux Universitaires de Strasbourg. Université Louis- Pasteur, Strasbourg I.
authors.forename: M
authors.initials: M
authors.lastname: Saleh
authors.forename: F
authors.initials: F
authors.lastname: Jehl
authors.forename: G
authors.initials: G
authors.lastname: Prevost
authors.forename: C
authors.initials: C
authors.lastname: Speeg-Schatz
authors.forename: T
authors.initials: T
authors.lastname: Bourcier
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016207:Cytokines / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology / Q000601:surgery; D006801:Humans; D007267:Injections; D051379:Mice; D008954:Models, Biological; D011183:Postoperative Complications / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012163:Retinal Detachment / Q000209:etiology / Q000517:prevention & control; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000209:etiology; D014821:Vitrectomy / Q000379:methods; D014822:Vitreous Body
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D016207:Cytokines