Polyprenylated xanthones from Garcinia lancilimba showing apoptotic effects against HeLa-C3 cells.
Three new prenylated xanthones, 1-3, along with ten known compounds, were isolated from the stem bark of Garcinia lancilimba. Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR spectra, as well as HR-MS experiments. Some of these compounds showed apoptotic effects or growth-inhibition effects against HeLa cells expressing a caspase sensor protein.
Han
Quan-Bing
QB
Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N. T., Hong Kong, P. R. China.
Tian
Hong-Lei
HL
Yang
Nian-Yun
NY
Qiao
Chun-Feng
CF
Song
Jing-Zheng
JZ
Chang
Donald C
DC
Luo
Kathy Q
KQ
Xu
Hong-Xi
HX
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis; D020169:Caspases / Q000378:metabolism; D002460:Cell Line; D028084:Clusiaceae / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer; D006367:HeLa Cells; D006801:Humans; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal; D044004:Xanthones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
C534859:1,3,5-trihydroxy-6-methoxy-7-(3-methylbut-2-enyl)xanthone; C534858:1,3-dihydroxy-5,6-dimethoxy-7-(3-methylbut-2-enyl)xanthone; C534860:3,4-dihydro-3,4,7,9,12-pentahydroxy-2,2-dimethyl-2H,6H-pyrano(3,2-b)xanthen-6-one; D000970:Antineoplastic Agents; D044004:Xanthones; D020169:Caspases