title: Histological and biomechanical effects of palatal sclerotherapy in the horse using sodium tetradecyl sulfate.
abstract: Palatal sclerotherapy using sodium tetradecyl sulfate has been suggested as a treatment for dorsal displacement of the soft palate in young Standardbred horses. The present study evaluated histological and biomechanical changes in the equine soft palate following trans-endoscopic treatment with a low dose of this compound. Two horses were euthanased and examined at 2 weeks and at 1, 2, 4 and 6 months post-sclerotherapy, while two further horses served as untreated controls. The technique was easily performed in all cases without major complications. On histological examination there was no evidence of palatal necrosis, inflammation or fibrosis in any of the treated or control animals. There was no variation in the density of palatal connective tissue between individuals, and on biomechanical assessment no significant difference in the stiffness of the palatal tissue was found between treated and control horses at any time. The lower dose of sodium tetradecyl sulfate used in this study relative to previous reports, might explain the absence of tissue alterations. This method of sclerotherapy did not alter the morphology or biomechanical properties of normal equine soft palates.
authors.affiliation: Université de Lyon, Lyon F-69003, France. jamunozmoran@yahoo.es
authors.forename: Juan A
authors.initials: JA
authors.lastname: Muñoz
authors.forename: Marcel
authors.initials: M
authors.lastname: Marcoux
authors.forename: Valérie
authors.initials: V
authors.lastname: Picandet
authors.forename: Christine L
authors.initials: CL
authors.lastname: Theoret
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Perron
authors.forename: Olivier M
authors.initials: OM
authors.lastname: Lepage
mesh_terms: D000402:Airway Obstruction / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D000818:Animals; D005260:Female; D006734:Horse Diseases / Q000473:pathology / Q000628:therapy*; D006736:Horses; D008297:Male; D010160:Palate, Soft / Q000187:drug effects / Q000473:pathology; D010805:Physical Conditioning, Animal / Q000502:physiology; D012597:Sclerosing Solutions / Q000627:therapeutic use*; D015911:Sclerotherapy / Q000379:methods / Q000662:veterinary*; D012981:Sodium Tetradecyl Sulfate / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D012597:Sclerosing Solutions; D012981:Sodium Tetradecyl Sulfate