Serotonergic changes produced by repeated exposure to forced swimming: correlation with behavior.
Repeated forced swim resulted in a decrease in the concentrations of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid in the hypothalamus and amygdala 24 h after the second swim session. This stressor also increased the mRNA levels for tryptophan hydroxylase-2, the rate-limiting enzyme in neuronal 5-HT synthesis, and 5-HT transporter in the midbrain as well as 5-HT1A receptor in the frontal cortex. Some of these serotonergic changes may be involved in the mechanisms of a depressive-like behavior induced by a stress of repeated swim in these animals.
Shishkina
Galina T
GT
Institute of Cytology and Genetics, Novosibirsk, Russia. gtshi@bionet.nsc.ru
Kalinina
Tatyana S
TS
Dygalo
Nikolay N
NN
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism; D003863:Depression / Q000378:metabolism; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism; D013315:Stress, Psychological; D013550:Swimming; D014365:Tryptophan Hydroxylase / Q000235:genetics / Q000378:metabolism
D050486:Serotonin Plasma Membrane Transport Proteins; C493232:Slc6a4 protein, rat; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin; D014365:Tryptophan Hydroxylase; C504569:tph2 protein, rat