In vitro anti-inflammatory activity of lignans isolated from Magnolia fargesii.
The overproduction of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) causes neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. Four lignans, (+)-eudesmin (1), (+)-magnolin (2), (+)-yangambin (3) and a new structure named as epimagnolin B (4) were isolated from Magnolia fargesii (Magnoliaceae) as the inhibitors of NO production in LPS-activated microglia. The most potent compound 4 inhibited the production of NO and PGE(2) and the expression of respective enzyme iNOS and COX-2 through the suppression of I-kappaB-alpha degradation and nuclear translocation of p65 subunit of NF-kappaB.
Kim
Jae Yeon
JY
College of Pharmacy, Sookmyung Women's University, 52 Hyochangwon-Gil, Yongsan-Gu, Seoul 140-742, Republic of Korea.
Lim
Hyo Jin
HJ
Lee
Da Yeon
da Y
Kim
Ji Sun
JS
Kim
Do Hee
DH
Lee
Hwa Jin
HJ
Kim
Hee Doo
HD
Jeon
Raok
R
Ryu
Jae-Ha
JH
D021581:Active Transport, Cell Nucleus; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D051546:Cyclooxygenase 2 / Q000378:metabolism; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism; D017705:Lignans / Q000737:chemistry*; D008031:Lignin / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000378:metabolism*; D000072000:NF-KappaB Inhibitor alpha; D009474:Neurons / Q000378:metabolism; D009569:Nitric Oxide / Q000737:chemistry / Q000378:metabolism; D010936:Plant Extracts / Q000378:metabolism*; D051996:Transcription Factor RelA / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D020672:I-kappa B Proteins; D017705:Lignans; C000606204:NFKBIA protein, human; D010936:Plant Extracts; D051996:Transcription Factor RelA; D000072000:NF-KappaB Inhibitor alpha; C094148:magnolin; D009569:Nitric Oxide; D008031:Lignin; D051546:Cyclooxygenase 2