title: Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004-2005.
abstract: We performed a retrospective case-series study of patients with influenza A (H5N1) admitted to the National Institute of Infectious and Tropical Diseases in Hanoi, Vietnam, from January 2004 through July 2005 with symptoms of acute respiratory tract infection, a history of high-risk exposure or chest radiographic findings such as pneumonia, and positive findings for A/H5 viral RNA by reverse transcription-PCR. We investigated data from 29 patients (mean age 35.1 years) of whom 7 (24.1%) had died. Mortality rates were 20% (5/25) and 50% (2/4) among patients treated with or without oseltamivir (p = 0.24), respectively, and were 33.3% (5/15) and 14.2% (2/14) among patients treated with and without methylprednisolone (p = 0.39), respectively. After exact logistic regression analysis was adjusted for variation in severity, no significant effectiveness for survival was observed among patients treated with oseltamivir or methylprednisolone.
authors.affiliation: National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam.
authors.forename: Nguyen Duc
authors.initials: ND
authors.lastname: Hien
authors.forename: Nguyen Hong
authors.initials: NH
authors.lastname: Ha
authors.forename: Nguyen Tuong
authors.initials: NT
authors.lastname: Van
authors.forename: Nguyen Thi Minh
authors.initials: NT
authors.lastname: Ha
authors.forename: Trinh Thi Minh
authors.initials: TT
authors.lastname: Lien
authors.forename: Nguyen Quoc
authors.initials: NQ
authors.lastname: Thai
authors.forename: Van Dinh
authors.initials: VD
authors.lastname: Trang
authors.forename: Takuro
authors.initials: T
authors.lastname: Shimbo
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kato
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawana
authors.forename: Samu
authors.initials: S
authors.lastname: Akita
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kudo
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000635:transmission / Q000821:virology; D007251:Influenza, Human / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use; D011200:Poultry / Q000821:virology; D015996:Survival Rate; D016896:Treatment Outcome; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D005938:Glucocorticoids; D053139:Oseltamivir; D008775:Methylprednisolone