Nickel-catalyzed oxidative coupling reactions of two different terminal alkynes using O(2) as the oxidant at room temperature: facile syntheses of unsymmetric 1,3-diynes.
Two different terminal alkynes now can be coupled together in the presence of NiCl(2).6H(2)O/CuI by using an excess of one of the terminal alkyne substrates. The new method employed 20 mol % TMEDA as the ligand and environmentally benign O(2) or air as the oxidant. It is the first example using Ni-salt as catalyst by employing air or O(2) as oxidant, which led to efficient heterocoupling of two different alkynes.
Yin
Weiyan
W
College of Chemistry and Molecular Sciences, Wuhan University, PR China.
He
Chuan
C
Chen
Mao
M
Zhang
Heng
H
Lei
Aiwen
A
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry; D053280:Diynes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction
D000480:Alkynes; D053280:Diynes; D003300:Copper; D009532:Nickel