title: Antibiotic clearance of Ehrlichia canis from dogs infected by intravenous inoculation of carrier blood.
abstract: Ehrlichia canis is the etiologic agent of canine monocytic ehrlichiosis (CME) and is a useful model for zoonotic tick-borne pathogens, many of which infect dogs. The purpose of this study was to evaluate rifampin and doxycycline regimens for clearance of E. canis infections in addition to alleviation of CME. Beagles were infected with E. canis by intravenous inoculation with carrier blood and treated with either rifampin or doxycycline after the acute phase of CME. Improved hematological values demonstrated that both treatments effectively relieved signs of the disease. Peripheral blood from all dogs became PCR negative after antibiotic treatment, suggesting that these infections were eliminated and that rifampin is an effective alternative chemotherapeutic agent for treatment of CME.
authors.affiliation: Department of Veterinary Preventive Medicine, Ohio State University, Columbus, Ohio, USA.
authors.forename: John J
authors.initials: JJ
authors.lastname: Schaefer
authors.forename: Jonathan
authors.initials: J
authors.lastname: Kahn
authors.forename: Glen R
authors.initials: GR
authors.lastname: Needham
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Rikihisa
authors.forename: S A
authors.initials: SA
authors.lastname: Ewing
authors.forename: R W
authors.initials: RW
authors.lastname: Stich
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000635:transmission*; D004285:Dogs; D004318:Doxycycline / Q000493:pharmacokinetics*; D041061:Ehrlichia canis / Q000378:metabolism*; D016873:Ehrlichiosis / Q000097:blood / Q000635:transmission*; D005260:Female; D012293:Rifampin / Q000493:pharmacokinetics*
chemical_list: D004318:Doxycycline; D012293:Rifampin