MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals.
MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.
Houzet
Laurent
L
Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. houzetl@niaid.nih.gov
Yeung
Man Lung
ML
de Lame
Valery
V
Desai
Dhara
D
Smith
Stephen M
SM
Jeang
Kuan-Teh
KT
D015331:Cohort Studies; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D035683:MicroRNAs / Q000097:blood* / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism
D035683:MicroRNAs