The neuromuscular blocking action of gamma-oxalolaudonium bromide.
In small animals gamma-oxalolaudonium caused flaccid paralysis; in the cat it produced a curare-like rather than a decamethonium-like block of neuromuscular transmission. The potency of gamma-oxalolaudonium was only 1/30 to 1/40 that of suxamethonium, but the duration of paralysis was very short, being about one-half that of equiactive doses of suxamethonium. Successive doses of gamma-oxalolaudonium were not cumulative and the paralysis could be antagonized by neostigmine. gamma-Oxalolaudonium exhibited low toxicity especially in artificially ventilated animals, and it did not show ganglionblocking or histamine-releasing activity to any large degree.
Brittain
R T
RT
Collier
H O
HO
D'Arcy
P F
PF