Clinical significance and different levels of urinary monocyte chemoattractant protein-1 in type 2 diabetes mellitus.
OBJECTIVE
Monocyte chemoattractant protein-1(MCP-1) is a cytokine that exhibits most potent chemotactic activity toward monocytes. It is suggested to be implicated in the development and progression of diabetic nephropathy by playing a role in infiltration of monocyte/macrophage. Recent studies have demonstrated that urinary monocyte chemoattractant protein-1 (uMCP-1) is different at different stages of diabetic nephropathy. Based on these findings, the aim of this study is to examine the level of uMCP-1 and its clinical significance at different stages of diabetic nephropathy and at the same time to describe the relationship between uMCP-1 and the various parameters.


METHODS
Fifty-nine cases with type 2 diabetes mellitus (T2DM) were divided into three groups according to urine albumin excretion (UAE): normal albuminuria group, microalbuminuria group and macroalbuminuria group. The levels of uMCP-1, protein excretion, blood urea nitrogen (BUN), serum creatinine (s-Cr), glycohemoglobin A1c (HbA1c), blood pressure and blood fat were measured in 59 patients with T2DM and 27 healthy adults as controls. Results Compared with normal control, levels of uMCP-1 in T2DM were significantly high, which were already elevated in normal albuminuria group. Compared with normal albuminuria group, levels of uMCP-1 in microalbuminuria group and macroalbuminuria group were significantly high. Levels of uMCP-1 in macroalbuminuria group were higher than those in microalbuminuria group. The level of uMCP-1 was positively correlated with UAE, systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) in T2DM patients, while it had no significant correlation with HbA1c(,) triglyceride (TG) and high density lipoprotein cholesterol (HDL-C).


CONCLUSIONS
MCP-1 is suggested to be implicated in the development and progression of diabetic nephropathy. It is very important to measure the level of uMCP-1 in the diagnosis and intervention of early diabetic nephropathy.
Wang
Qiu-yue
QY
Department of Endocrinology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China. WQYabcd@Yahoo.com.cn
Chen
Fen-qin
FQ
D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000175:diagnosis / Q000209:etiology; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000032:analysis / Q000378:metabolism / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism / Q000652:urine*; D003928:Diabetic Nephropathies / Q000175:diagnosis* / Q000378:metabolism / Q000652:urine; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests
D018932:Chemokine CCL2