title: Enantioselective total synthesis of (+)-cassiol.
abstract: An enantioselective total synthesis of (+)-cassiol is reported. The complex derived from Pd(2)(pmdba)(3) and enantiopure t-BuPHOX ligand catalyzes enantioconvergent decarboxylative alkylation to generate the quaternary carbon stereocenter at an early stage. The overall synthetic strategy involves a convergent late-stage coupling of two fragments. The synthesis features a longest linear sequence of eight steps.
authors.affiliation: The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 164-30, Pasadena, California 91125, USA.
authors.forename: Krastina V
authors.initials: KV
authors.lastname: Petrova
authors.forename: Justin T
authors.initials: JT
authors.lastname: Mohr
authors.forename: Brian M
authors.initials: BM
authors.lastname: Stoltz
mesh_terms: D002384:Catalysis; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D012717:Sesquiterpenes; C538845:cassiol