Lack of clinical usefulness of Das-1 monoclonal antibody and mucin expression as risk markers of gastric carcinoma in patients with gastric intestinal metaplasia.
Our aim was to evaluate the usefulness of the monoclonal antibody Das-1 as a premalignant marker of gastric intestinal metaplasia (GIM) associated with gastric cancer and its association with mucin expression. We evaluated Das-1 and mucin expression in 4 groups: 1 (n = 50), gastric carcinoma, paired samples of the cancer area and GIM away from the tumor; 2 (n = 25), gastric or duodenal ulcer with Helicobacter pylori infection with GIM and chronic gastritis; 3 (n = 25),H pylori- autoimmune chronic atrophic gastritis with GIM; and 4 (n = 25),H pylori- chronic gastritis without GIM. Das-1 immunostaining was observed in 20 (40%) of 50 cases in cancer areas. The expression of Das-1 in GIM from group 1 cases away from the cancer area was different from that in GIM from nontumor cases (groups 2 and 3): 13 (26%) of 50 vs 2 (8%) and 0 (0%) of 25 (P = .004). There was no association between Das-1 and mucin expression. Das-1 expression was associated with GIM from patients with gastric cancer. However, this relation was weaker than previously reported, precluding clinical usefulness as a premalignant marker of GIM.
Forné
Montserrat
M
Department of Gastroenterology, Hospital Universitari Mútua Terrassa, Terrassa, Spain.
Fernández-Bañares
Fernando
F
González-Mínguez
Clarisa
C
Casalots
Jaume
J
Poblet-Mas
Núria
N
Garcia-Gil
L Jesús
LJ
Esteve
Maria
M
Rosinach
Mercè
M
Espinós
Jorge
J
Loras
Carme
C
Salas
Antonio
A
Viver
Josep M
JM
D000328:Adult; D000368:Aged; D000906:Antibodies; D000911:Antibodies, Monoclonal; D005756:Gastritis / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008679:Metaplasia / Q000473:pathology*; D008875:Middle Aged; D009077:Mucins / Q000096:biosynthesis*; D012306:Risk; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000209:etiology* / Q000473:pathology; D013276:Stomach Ulcer / Q000473:pathology / Q000503:physiopathology
D000906:Antibodies; D000911:Antibodies, Monoclonal; C467479:DAS-1 protein, human; D009077:Mucins