title: The recovery rate at the human terminal ileum of an orally administered non-digestive oligosaccharide (raffinose).
abstract: We clarified how raffinose, one of the non-digestive oligosaccharides, reaches the large intestine. Seven healthy male volunteers were given a test meal containing 10.0 g raffinose. A double-lumen tube was placed in the terminal ileum, and the ileal contents were aspirated through the tube. The amounts of raffinose were orally administered and collected from the terminal ileum and were compared with each other. The result was that the mean+/-standard error percentage of the amount of ingested raffinose collected in the terminal ileum was 97.1+/-2.4%. Furthermore, the average times taken for 20%, 40%, 60% and 80% of raffinose to reach the terminal ileum were 2.0+/-0.6 h, 2.6+/-0.7 h, 3.6+/-0.7 h and 4.9+/-0.7 h, respectively. In conclusion, approximately 100% of ingested raffinose was recovered in the terminal ileum in the present study. This corresponds with the present generally accepted definition of a dietary fibre.
authors.affiliation: Department of Social Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori, Japan.
authors.forename: Sen
authors.initials: S
authors.lastname: Shimaya
authors.forename: Tadashi
authors.initials: T
authors.lastname: Shimoyama
authors.forename: Shinsaku
authors.initials: S
authors.lastname: Fukuda
authors.forename: Masashi
authors.initials: M
authors.lastname: Matsuzaka
authors.forename: Ippei
authors.initials: I
authors.lastname: Takahashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Umeda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Chinda
authors.forename: Daisuke
authors.initials: D
authors.lastname: Saito
authors.forename: Juichi
authors.initials: J
authors.lastname: Sakamoto
authors.forename: Taizo
authors.initials: T
authors.lastname: Nagura
authors.forename: Kazuma
authors.initials: K
authors.lastname: Danjo
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Nakaji
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D004043:Dietary Fiber; D005772:Gastrointestinal Transit / Q000502:physiology*; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D007408:Intestinal Absorption / Q000502:physiology*; D008297:Male; D011887:Raffinose / Q000493:pharmacokinetics*; D013997:Time Factors; D055815:Young Adult
chemical_list: D004043:Dietary Fiber; D011887:Raffinose