Prognosticators and the role of lymphadenectomy in uterine leiomyosarcomas.
OBJECTIVE
To analyze prognostic factors, the role of lymphadenectomy and postoperative adjuvant treatments in patients with uterine leiomyosarcomas (LMS).


METHODS
Sixty-three patients with uterine LMS are retrospectively analyzed with respect to both DFS and OS.


RESULTS
Multivariate DFS analysis revealed percentage necrosis to be the unique factor to be significant (median DFS was 3.31 years for <25% necrosis and 0.78 for >25% necrosis). Multivariate analysis revealed the mitotic counts to be the unique significant factor affecting the OS (median OS was 7.20 and 1.73 years, respectively, for patients with mitotic counts of 1-5 and >6; respectively). Median DFS was 2.51 years for patients who had undergone lymphadenectomy and 2.36 years for remaining who did not have a lymphadenectomy procedure (P = 0.4). With respect to OS, median values were 2.44 and 3.16 years, respectively (P = 0.7). Number of the resected lymph nodes was also not significant for both OS and DFS.


CONCLUSIONS
Mitotic counts and percentage necrosis have significant effects on OS and DFS; respectively. Neither the performance nor the extent of lymphadenectomy has an effect on patient survival.
Ayhan
Ali
A
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Baskent University School of Medicine, Tandogan, Ankara, Turkey.
Aksan
Guldeniz
G
Gultekin
Murat
M
Esin
Sertac
S
Himmetoglu
Cigdem
C
Dursun
Polat
P
Usubutun
Alp
A
Yuce
Kunter
K
D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007890:Leiomyosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008197:Lymph Node Excision / Q000706:statistics & numerical data*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D008940:Mitotic Index; D015999:Multivariate Analysis; D009336:Necrosis; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery