[A case of esophageal cancer patient who developed tumor lysis syndrome after chemotherapy].
We report here a case of esophageal cancer patient who developed tumor lysis syndrome after chemotherapy. A 57- year-old man received esophagectomy for advanced esophageal cancer. CT study revealed multiple lymphnode metastases, multiple bone metastases and multiple lung metastases after 15 months from the operation. So, chemotherapy was performed for the patient. Eleven days following the administration of docetaxel: 30 mg/m2 and nedaplatin: 30 mg/m2, the patient developed TLS (serum creatinine: 8.57 mg/dL, uric acid: 11.0 mg/dL, serum potassium: 6.3 mEq/L, serum phosphorus: 7.18 mg/dL). The patient responded well to an appropriate treatment with a combination of vigorous intravenous hydration, carperitide, allpurinol and potassium citrate sodium citrate. This case report describes the first patient to develop TLS following chemotherapy for esophageal cancer.
Tokunou
Kazuhisa
K
Dept. of Digestive Surgery and Surgical Oncology (Dept. of Surgery II), Yamaguchi University Graduate School of Medicine.
Takeda
Shigeru
S
Yoshino
Shigefumi
S
Nishimura
Taku
T
Oka
Masaaki
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D000077143:Docetaxel; D004938:Esophageal Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D043823:Taxoids / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D015275:Tumor Lysis Syndrome / Q000097:blood
D009944:Organoplatinum Compounds; D043823:Taxoids; D000077143:Docetaxel; C053989:nedaplatin