Histopathological predictor for regional lymph node metastasis in gastric cancer.
Regional lymph node metastasis in gastric cancer is a definitive indicator of the patient's prognosis. The goal of this study was to identify the predictors for lymph node metastasis among all the possible histopathological parameters, especially by conducting an objective discrimination of the lymphatic and blood vessels. A total of 210 resected primary gastric cancers with or without lymph node metastasis were evaluated based on the conventional histopathological parameters together with immunohistochemistry using antisera-recognizing lymphatic endothelial hyaluronan receptor-1 (LYVE-1), von Willebrand factor, and lymphangiogenesis promoter vascular endothelial growth factor-C (VEGF-C) antibodies. A multivariate regression analyses of the results indicated that only lymphatic invasion was a significant independent predictor of lymph node metastasis at any stage of cancer invasion. VEGF-C expression was partially related to lymph node metastasis in early gastric cancer. The identification of lymphatic invasion by LYVE-1 antibody is therefore useful to predict regional lymph node metastasis in gastric cancer.
Morita
Hiroshi
H
Department of Pathology, School of Medicine, Toho University, Tokyo, Japan. morita-hiroshi@med.toho-u.ac.jp
Ishikawa
Yukio
Y
Akishima-Fukasawa
Yuri
Y
Ito
Kinji
K
Akasaka
Yoshikiyo
Y
Nishimura
Chiaki
C
Igarashi
Yoshinori
Y
Miki
Kazumasa
K
Ishii
Toshiharu
T
D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016015:Logistic Models; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000098:blood supply / Q000737:chemistry / Q000473:pathology*; D042582:Vascular Endothelial Growth Factor C / Q000032:analysis; D033921:Vesicular Transport Proteins / Q000032:analysis
C119248:LYVE1 protein, human; D042582:Vascular Endothelial Growth Factor C; D033921:Vesicular Transport Proteins