title: Apolipoprotein E4 allele influences the response of plasma triglyceride levels to tamoxifen in breast cancer patients.
abstract: BACKGROUND
  Apolipoprotein E4 (APOE4) allele is an important risk factor for breast cancer and affects clearance of chylomicron remnants. Tamoxifen therapy increases serum triglyceride levels and sometimes inducing severe hypertriglyceridemia in breast cancer patients.
  
  
  METHODS
  Thirty-three women with breast cancer were recruited to examine the APOE polymorphism and fasting plasma lipid profiles before and after tamoxifen treatment for 6 months.
  
  
  RESULTS
  We found that plasma lipid profiles changed in accordance with the APOE4 allele after tamoxifen treatment for 6 months. Especially plasma triglyceride levels significantly decreased in the APOE4-positive patients (p=0.025), while there was no change in APOE4-negative patients (p=0.189). The total plasma cholesterol levels were reduced in APOE-4 positive patients after 6-month tamoxifen treatment (p=0.014). The levels of plasma low density lipoprotein cholesterol and high density lipoprotein cholesterol significantly decreased in both APOE4-negative and APOE4-positive patients.
  
  
  CONCLUSIONS
  These findings indicate that the effects of tamoxifen on plasma triglyceride levels are modified by APOE polymorphism. Breast cancer patients with APOE4 allele have low plasma triglyceride levels when receiving tamoxifen therapy. Therefore, we suggest that APOE gene polymorphism is a critical validation before tamoxifen treatment in breast cancer patients.
authors.affiliation: Department of Biochemistry, College of Medicine, China Medical University, Taiwan, ROC. nwchang@mail.cmu.edu.tw
authors.forename: Nai-Wen
authors.initials: NW
authors.lastname: Chang
authors.forename: Fei-Na
authors.initials: FN
authors.lastname: Chen
authors.forename: Chen-Teng
authors.initials: CT
authors.lastname: Wu
authors.forename: Chin-Fen
authors.initials: CF
authors.lastname: Lin
authors.forename: Dar-Ren
authors.initials: DR
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D053327:Apolipoprotein E4 / Q000235:genetics*; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*
chemical_list: D053327:Apolipoprotein E4; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D013629:Tamoxifen