Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment.
HIV-associated cognitive neurological disorders (HAND) prevail in the antiretroviral therapy era. Proteomics analysis of CSF revealed expression of Cu/Zn superoxide dismutase (Cu/Zn SOD) in Hispanic women with cognitive impairment (CI). We tested the hypothesis that there is reduced capacity of antioxidant enzymes in CI by measures of expression and activity of Cu/Zn SOD, catalase, and Se-glutathione peroxidase in HAND. Our results showed that the function of these antioxidants was decreased in the CSF and monocytes of women with CI. These findings have important implications regarding their possible contribution to oxidative stress and in the diagnosis and therapy for HAND.
Velázquez
Ixane
I
Department of Microbiology and Medical Zoology, University of Puerto Rico Medical Sciences Campus, Biomedical Building I, Suite 310, San Juan, 00935, Puerto Rico.
Plaud
Marinés
M
Wojna
Valerie
V
Skolasky
Richard
R
Laspiur
Juliana Pérez
JP
Meléndez
Loyda M
LM
D015526:AIDS Dementia Complex / Q000097:blood / Q000134:cerebrospinal fluid / Q000201:enzymology* / Q000821:virology; D000328:Adult; D000704:Analysis of Variance; D002374:Catalase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D016001:Confidence Intervals; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D005979:Glutathione Peroxidase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006630:Hispanic or Latino; D006801:Humans; D008137:Longitudinal Studies; D009000:Monocytes / Q000201:enzymology*; D012189:Retrospective Studies; D013482:Superoxide Dismutase / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase