title: Chromatin structure contribution to the synaptonemal complex formation.
abstract: Meiosis is a key cellular and molecular process for sexual reproduction contributing to the genetic variability of organisms. This process takes place after DNA replication and consists in a double cellular division, giving rise to four haploid daughter cells or gametes. Meiotic recombination between homologous chromosomes, in the meiotic prophase I, is mediated by a tripartite structure named Synaptonemal Complex (SC). The SC is a peptidic scaffold in which the chromatin of homologous chromosomes is organized during the pachytene stage, holding chromosomes together until the meiotic recombination and genetic exchange have taken place. The role of chromatin structure in formation of the SC and the meiotic recombination at meiotic prophase I remain largely unknown. In this review we address the epigenome contribution to the SC formation at meiotic prophase I, with particular attention on the chromatin structure modifications occurring during the sub-stages of meiotic prophase I.
authors.affiliation: Instituto de Fisiología Celular, Departamento de Genética Molecular, Universidad Nacional Autónoma de México (UNAM), Apartado Postal 70-242, México D.F 04510, México.
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Hernández
authors.forename: G H
authors.initials: GH
authors.lastname: Vázquez-Nin
authors.forename: O M
authors.initials: OM
authors.lastname: Echeverría
authors.forename: F
authors.initials: F
authors.lastname: Recillas-Targa
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology*; D002875:Chromosomes / Q000502:physiology; D019175:DNA Methylation / Q000502:physiology; D004261:DNA Replication / Q000502:physiology; D044127:Epigenesis, Genetic; D008540:Meiosis / Q000502:physiology*; D049469:Meiotic Prophase I / Q000502:physiology; D011995:Recombination, Genetic; D013573:Synaptonemal Complex / Q000502:physiology*
chemical_list: D002843:Chromatin