title: Gag p27-specific B- and T-cell responses in Simian immunodeficiency virus SIVagm-infected African green monkeys.
abstract: Nonpathogenic simian immunodeficiency virus SIVagm infection of African green monkeys (AGMs) is characterized by the absence of a robust antibody response against Gag p27. To determine if this is accompanied by a selective loss of T-cell responses to Gag p27, we studied CD4(+) and CD8(+) T-cell responses against Gag p27 and other SIVagm antigens in the peripheral blood and lymph nodes of acutely and chronically infected AGMs. Our data show that AGMs can mount a T-cell response against Gag p27, indicating that the absence of anti-p27 antibodies is not due to the absence of Gag p27-specific T cells.
authors.affiliation: Institut Pasteur, Régulation des Infections Rétrovirales, Paris, France.
authors.forename: José-Manuel
authors.initials: JM
authors.lastname: Lozano Reina
authors.forename: David
authors.initials: D
authors.lastname: Favre
authors.forename: Zeljka
authors.initials: Z
authors.lastname: Kasakow
authors.forename: Véronique
authors.initials: V
authors.lastname: Mayau
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Nugeyre
authors.forename: Thierno
authors.initials: T
authors.lastname: Ka
authors.forename: Abdourahmane
authors.initials: A
authors.lastname: Faye
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Miller
authors.forename: Daniel
authors.initials: D
authors.lastname: Scott-Algara
authors.forename: Joseph M
authors.initials: JM
authors.lastname: McCune
authors.forename: Françoise
authors.initials: F
authors.lastname: Barré-Sinoussi
authors.forename: Ousmane M
authors.initials: OM
authors.lastname: Diop
authors.forename: Michaela C
authors.initials: MC
authors.lastname: Müller-Trutwin
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001769:Blood / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D015683:Gene Products, gag / Q000276:immunology*; D015483:HIV Antibodies / Q000097:blood; D008198:Lymph Nodes / Q000276:immunology; D016131:Lymphocyte Subsets / Q000276:immunology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*
chemical_list: C066594:Gag protein p27, Simian immunodeficiency virus; D015683:Gene Products, gag; D015483:HIV Antibodies