Two novel A-seco-rearranged lanostane triterpenoids from Abies sachalinensis.
Further chemical study led to two new A-seco-rearranged lanostane triterpenoid derivatives (1-2) and one known compound Abiesanolide C (3) from the ethyl acetate (EtOAc) soluble fraction of the MeOH extract of Abies sachalinensis needles. The new compounds were identified as 3,4-seco-8-(14-->13R)abeo-17,13-friedo-9beta-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oic acid and methyl-3,4-seco-8-(14-->13R) abeo-17,13-friedo-9beta-lanosta-4(28), 7, 14, 24-tetraen-26,23-olide-23-hydroxy-3-oate, respectively. Structural determination of these compounds were carried out by the spectral studies especially by the two digital (2D)-NMR and high-resolution (HR)-MS experiences.
Sun
Bohang
B
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenhe District, Shenyang, 110016, PR China.
Hou
Bailing
B
Huang
Jian
J
Wu
Lijun
L
Kuroyanagi
Masonori
M
Gao
Huiyuan
H
D028202:Abies / Q000737:chemistry*; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
C534745:3,4-seco-8-(14-13R)abeo-17,13-friedo-9beta-lanosta-4(28),7,14,24-tetraen-26,23-olide-23-hydroxy-3-oic acid; D014315:Triterpenes; C534746:methyl-3,4-seco-8-(14-3R) abeo-17,13-friedo-9beta-lanosta-4(28),7,14, 24-tetraen-26,23-olide-23-hydroxy-3-oate; D007810:Lanosterol