Volume-selective magnetic resonance imaging using an adjustable, single-sided, portable sensor.
Portable, single-sided NMR sensors can operate under conditions inaccessible to conventional NMR while featuring lower cost, portability, and the ability to analyze arbitrary-sized objects. Such sensors can nondestructively probe the interior of samples by collecting images and measuring relaxation and diffusion constants, and, given careful shimming schemes, even perform chemical analysis. The inherently strong magnetic-field gradients of single-sided sensors developed so far has prevented imaging of materials with high water content, such as biological tissues, over large volumes whereas designs with more homogeneous fields suffer from low field strength and typically cannot probe volumes larger than approximately 10 cm(3). We present a design with a continuously adjustable sensitive volume, enabling the effective volume to be enlarged several fold. This capability allows for imaging in reasonable times of much bigger objects and opens the door to the possibility of clinical imaging with portable sensors. We demonstrate MRI in axial and sagittal planes, at different depths of the sensitive volume and T(1)-weighted contrast in a tissue sample.
Paulsen
Jeffrey L
JL
College of Chemistry, University of California, Berkeley, CA 94720, USA.
Bouchard
Louis S
LS
Graziani
Dominic
D
Blümich
Bernhard
B
Pines
Alexander
A
D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation* / Q000379:methods*; D014867:Water / Q000737:chemistry*
D014867:Water