title: Synthesis of 3-hydroxypyridines using ruthenium-catalyzed ring-closing olefin metathesis.
abstract: New synthetic routes to substituted 3-hydroxypyridines 6 are presented. Ring-closing olefin metathesis (RCM)/elimination and RCM/oxidation/deprotection of nitrogen-containing dienes 4 are the key processes of the routes. An application of RCM/oxidation/deprotection to the synthesis of 3-aminopyridine 13f is also described.
authors.affiliation: Department of Chemistry, Graduate School of Science, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshida
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Kawagoe
authors.forename: Kazushi
authors.initials: K
authors.lastname: Hayashi
authors.forename: Shingo
authors.initials: S
authors.lastname: Horiuchi
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Imamoto
authors.forename: Akira
authors.initials: A
authors.lastname: Yanagisawa
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000631:Aminopyridines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000631:Aminopyridines; D011725:Pyridines; C014047:hydroxypyridines; C031283:3-aminopyridine; D012428:Ruthenium