title: Psychological reactions to progression of metastatic breast cancer--an interview study.
abstract: Knowledge about how patients experience their situation at the point of disease progression after first-line chemotherapy is limited. It is important to investigate this area to better understand and support women with advanced-stage disease. The study explored psychological reactions and coping on disease progression after first-line chemotherapy among women with metastatic breast cancer. Interviews were held with 20 patients with breast cancer who were included in a randomized study of first-line chemotherapy for metastatic breast cancer. Three themes emerged. "Before the information": most of the women reported symptoms related to the disease progression before information about treatment failure. Thus, they were not surprised by the information. "Immediate after information": a range of psychological reactions were described. Most patients experienced sadness, disappointment, and setback in view of disease progress. Anxiety and worry about the future were reported. "Life after being informed of disease progression": Various strategies to cope with their situation were used, for example, work, social support, and church attendance. All women had disease progression. Worry was the most common emotional response. A number of strategies were used to cope with the situation. Most of the women responded with acceptance.
authors.affiliation: Institute of Health and Care Sciences, The Sahlgrenska Academy, Göteborg University, Göteborg, Sweden. helene.m.svensson@vgregion.se
authors.forename: Helene
authors.initials: H
authors.lastname: Svensson
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Brandberg
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Einbeigi
authors.forename: Thomas
authors.initials: T
authors.lastname: Hatschek
authors.forename: Karin
authors.initials: K
authors.lastname: Ahlberg
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001007:Anxiety; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000523:psychology*; D018450:Disease Progression; D004644:Emotions; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D017211:Treatment Failure