Urinary cystatin C can improve the renal safety follow-up of tenofovir-treated patients.
A receiver operating curve analysis was performed to assess the predictive value of the urinary cystatin C to urinary creatinine ratio for the renal monitoring of tenofovir. Urinary cystatin C to urinary creatinine ratio was measured in 37 samples from patients referred for suspected tenofovir-induced Fanconi syndrome. The best threshold (14 microg/mmol) was associated with sensitivity, 90.9%; specificity, 88.5%; positive predictive value, 76.9%; and negative predictive value, 95.8%. Urinary cystatin C to urinary creatinine ratio allows to rule out a Fanconi syndrome in most cases; thus, it should be used for the safety follow-up of nucleotide reverse transcriptase inhibitor-treated patients.
Jaafar
Acil
A
CHU Rangueil, Department of Clinical Physiology and Université Toulouse III Paul Sabatier, Toulouse, France.
Séronie-Vivien
Sophie
S
Malard
Laurence
L
Massip
Patrice
P
Chatelut
Etienne
E
Tack
Ivan
I
D000225:Adenine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000652:urine; D055316:Cystatin C / Q000652:urine*; D005198:Fanconi Syndrome / Q000139:chemically induced* / Q000175:diagnosis*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D017674:Hypophosphatemia / Q000139:chemically induced / Q000175:diagnosis; D063065:Organophosphonates / Q000009:adverse effects* / Q000627:therapeutic use; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D000068698:Tenofovir
D019380:Anti-HIV Agents; D015415:Biomarkers; D055316:Cystatin C; D063065:Organophosphonates; D000068698:Tenofovir; D003404:Creatinine; D000225:Adenine