Synthesis and antibacterial property of quinolines with potent DNA gyrase activity.
Synthesis of a series of novel tetrahydroquinoline annulated heterocycles has been accomplished by intramolecular imino and bisimino Diels-Alder reaction. These compounds were evaluated for their antibacterial activity. All the synthetic compounds, exhibited good antibacterial activity against microorganisms of which one of them 7 was found to be as active as the antibiotic ciplofloxacin and is found to have MIC value of 2.5 mg/mL against Escherichia coli.
Ramesh
Ekambaram
E
Department of Organic Chemistry, Guindy Campus, University of Madras, Chennai 600025, India.
Manian
Rathna Durga R S
RD
Raghunathan
Ragavachary
R
Sainath
Shilpakala
S
Raghunathan
Malathi
M
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002939:Ciprofloxacin; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
D000900:Anti-Bacterial Agents; D011804:Quinolines; D059005:Topoisomerase II Inhibitors; D002939:Ciprofloxacin