title: Strong association of MRI meniscal derangement and bone marrow lesions in knee osteoarthritis: data from the osteoarthritis initiative.
abstract: BACKGROUND
  Meniscal damage is common in knee Osteoarthritis (OA) and predictive of structural progression, suggesting that their disruption plays a role in the development of OA. The bone marrow lesion (BML) is associated with pain and is a strong risk factor for structural progression. These lesions are associated with abnormal loading in a knee joint. Therefore, our hypothesis was that in those with symptomatic knee OA, large BMLs would be associated with ipsi-compartmental meniscal derangement.
  
  
  METHODS
  This was a cross-sectional study of a subsample of the Osteoarthritis Initiative where one set of magnetic resonance (MR) images from each participant was scored for tibiofemoral BMLs and meniscal derangement. We performed chi-squared tests comparing the prevalence of large BMLs in those with ipsi-compartmental meniscal derangement and those without.
  
  
  RESULTS
  160 Participants had a mean age of 61 (+/-9.9), mean BMI of 30.3 (+/-4.7) and 50% were female. 79% of medial and 39% of lateral menisci showed MRI (Magnetic Resonance Imaging) derangement. In those with medial meniscal MRI derangement, 44% had large medial BMLs while in those without medial meniscal derangement, 0% had large BMLs. Similar results were seen in the lateral compartment.
  
  
  CONCLUSIONS
  Medial and lateral MRI meniscal derangement are highly prevalent in symptomatic knee OA and BMLs are highly associated with ipsi-compartmental MRI meniscal derangement.
authors.affiliation: Tufts Medical Center, Boston, MA 02111, United States. glo@tuftsmedicalcenter.org
authors.forename: G H
authors.initials: GH
authors.lastname: Lo
authors.forename: D J
authors.initials: DJ
authors.lastname: Hunter
authors.forename: M
authors.initials: M
authors.lastname: Nevitt
authors.forename: J
authors.initials: J
authors.lastname: Lynch
authors.forename: T E
authors.initials: TE
authors.lastname: McAlindon
mesh_terms: D001853:Bone Marrow / Q000293:injuries / Q000473:pathology*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008592:Menisci, Tibial / Q000473:pathology*; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000453:epidemiology / Q000473:pathology*; D012307:Risk Factors; D000070600:Tibial Meniscus Injuries; D016474:Weight-Bearing / Q000502:physiology*