title: Effect of spironolactone on hypertrophy of left ventricular myocardium in wistar rats with experimental uremia.
abstract: Chronic renal failure was modeled in rats by partial nephrectomy. Blood pressure, heart rate, concentrations of aldosterone, urea, creatinine, electrolytes, and protein, index of hypertrophy of visceral organs, and 24-h diuresis were evaluated. In rats treated with spironolactone, the index of myocardial hypertrophy did not considerably differ from that in sham-operated animals, whereas in untreated rats the test parameters considerably differ from the control. We concluded that the blockade of aldosterone receptors with spironolactone produced a cardioprotective effect in Wistar rats with subtotal nephrectomy.
authors.affiliation: Department of Nephrology and Dialysis, Faculty of Postgraduate Education, St. Petersburg, Russia.
authors.forename: A Zh
authors.initials: AZh
authors.lastname: Karabayeva
authors.forename: A M
authors.initials: AM
authors.lastname: Esaian
authors.forename: I G
authors.initials: IG
authors.lastname: Kayukov
authors.forename: M M
authors.initials: MM
authors.lastname: Parastaeva
authors.forename: O N
authors.initials: ON
authors.lastname: Beresneva
authors.forename: L V
authors.initials: LV
authors.lastname: Kotenko
authors.forename: I E
authors.initials: IE
authors.lastname: Sevastyanova
mesh_terms: D000450:Aldosterone / Q000378:metabolism; D000818:Animals; D003404:Creatinine / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000188:drug therapy / Q000378:metabolism; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013148:Spironolactone / Q000494:pharmacology*; D014508:Urea / Q000378:metabolism; D014511:Uremia / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D004573:Electrolytes; D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone; D000450:Aldosterone; D014508:Urea; D003404:Creatinine