[Relationship between microalbuminuria and cognition in primary hypertension patients].
OBJECTIVE
To study the relationship between microalbuminuria and cognitive impairment in primary hypertensive patients.


METHODS
A total of 200 hypertensive patients were included in this study. Blood pressure, body height and weight, total cholesterol, triglyceride, fasting plasma glucose, 2 hour-postprandial blood sugar, insulin level and urine protein were measured. Microalbuminuria and urine creatinine were determined in patients without proteinuria. The risk stratification of hypertension was evaluated. The cognitive function and calculate scores were tested by the Mini Mental State Examination (MMSE) and patients were divided into two groups: > 24-scores were classified as normal cognition group, < or = 24-scores as impaired cognition group.


RESULTS
Among the 200 hypertensive patients, proteinuria was detected in 25 patients. There was no significant difference in the cognitive function between patients with and without proteinuria (P > 0.05). There were significant differences on age, educational level, occupation, smoking, history of coronary heart disease, history of cerebrovascular disease, the risk stratification of hypertension, microalbuminuria/creatinine ratio, postprandial insulin level, cholesterol and diastolic blood pressure between normal cognition function group and impaired cognition function group (all P < 0.05). Multivariate logistic regression analysis showed that microalbuminuria, educational level and the risk stratification of hypertension were significantly correlated to cognition impairment (all P < 0.05).


CONCLUSIONS
Educational level, the risk stratification of hypertension and microalbuminuria are associated with cognitive impairment in this patient cohort.
Chen
Xiao-ping
XP
Department of Cardiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Wu
Juan
J
Peng
Qing
Q
Huang
He
H
Mao
Zhen-xing
ZX
Huang
Yan
Y
Jiang
Ling-yun
LY
Zhu
Ye
Y
Zheng
Ting-lin
TL
Zhou
Xiao-mei
XM
Li
Hong-ping
HP
Huang
De-jia
DJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria / Q000150:complications*; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011795:Surveys and Questionnaires