title: The liver--a potential new player in islet regeneration?
abstract: Pancreatic islet beta cell mass expands in response to certain physiological conditions such as pregnancy and obesity, but the signaling pathways involved are not well understood. Possible insights come from a newly described regulatory circuit through which obesity-enhanced kinase signaling in the liver triggers expansion of islet mass and enhanced insulin secretion.
authors.affiliation: Sarah W. Stedman Nutrition and Metabolism Center, Duke University Medical Center, Durham, NC 27704, USA.
authors.forename: Larry G
authors.initials: LG
authors.lastname: Moss
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Newgard
mesh_terms: D002490:Central Nervous System / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D007515:Islets of Langerhans / Q000502:physiology*; D008099:Liver / Q000201:enzymology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction
chemical_list: D019950:Mitogen-Activated Protein Kinase 1