Prostate cancer genomics: towards a new understanding.
Recent genetics and genomics studies of prostate cancer have helped to clarify the genetic basis of this common but complex disease. Genome-wide studies have detected numerous variants associated with disease as well as common gene fusions and expression 'signatures' in prostate tumours. On the basis of these results, some advocate gene-based individualized screening for prostate cancer, although such testing might only be worthwhile to distinguish disease aggressiveness. Lessons learned from these studies provide strategies for further deciphering the genetic causes of prostate cancer and other diseases.
Witte
John S
JS
Department of Epidemiology and Biostatistics, Institute for Human Genetics, University of California, San Francisco, 513 Parnassus Avenue, Room S965, San Francisco, California 94143-0794, USA. jwitte@ucsf.edu
D015415:Biomarkers / Q000032:analysis; D005820:Genetic Testing / Q000379:methods; D023281:Genomics / Q000639:trends*; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000503:physiopathology
D015415:Biomarkers