Phagocytosis of Candida albicans by RNAi-treated Drosophila S2 cells.
Phagocytosis is a highly conserved aspect of innate immunity. Drosophila melanogaster has an innate immune system with many similarities to that of mammals and has been used to successfully model many aspects of innate immunity. The recent availability of Ribo Nucleic Acid interference (RNAi) libraries for Drosophila has made it possible to efficiently screen for genes important in aspects of innate immunity. We have screened an RNAi library representing 7216 fly genes conserved among metazoans to identify proteins required for the phagocytosis of the human fungal pathogen Candida albicans.
Stroschein-Stevenson
Shannon L
SL
Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, USA.
Foley
Edan
E
O'Farrell
Patrick H
PH
Johnson
Alexander D
AD
D000818:Animals; D001483:Base Sequence; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity*; D002460:Cell Line; D017931:DNA Primers / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D015723:Gene Library; D017344:Genes, Insect; D054884:Host-Pathogen Interactions / Q000235:genetics / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D010587:Phagocytosis / Q000235:genetics; D034622:RNA Interference
D017931:DNA Primers