title: Bronchopulmonary disposition of micafungin in healthy adult volunteers.
abstract: By way of bronchoscopy and bronchoalveolar lavage, intrapulmonary steady-state concentrations of micafungin administered at 150 mg daily to 15 healthy volunteers were determined at 4, 12, and 24 h after the third dose. The micafungin disposition was predominantly intracellular, with approximately 106% penetration into alveolar macrophages and 5% penetration into epithelial lining fluid.
authors.affiliation: Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA.
authors.forename: Anthony M
authors.initials: AM
authors.lastname: Nicasio
authors.forename: Pamela R
authors.initials: PR
authors.lastname: Tessier
authors.forename: David P
authors.initials: DP
authors.lastname: Nicolau
authors.forename: R Fredrick
authors.initials: RF
authors.lastname: Knauft
authors.forename: John
authors.initials: J
authors.lastname: Russomanno
authors.forename: Eric
authors.initials: E
authors.lastname: Shore
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Kuti
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001806:Blood Urea Nitrogen; D001980:Bronchi / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D001999:Bronchoscopy; D017321:Clinical Trials, Phase I as Topic; D054714:Echinocandins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000378:metabolism; D000077551:Micafungin; D008875:Middle Aged; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000378:metabolism
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin