Cortisol controlled release by mesoporous silica.
In this study four types of SBAs were synthesized and then impregnated with hydrocortisone. One is a straight SBA-15, obtained using Pluronics P123 as structuring agent; two others were modified using 1,3,5-trimethylbenzene as additive, and the fourth one was prepared using sodium iodide as additive. Three of these have in common a p6 mm symmetry with nanotubes packed hexagonally, yet they differ in their functional groups. The fourth sample is basically disordered. The drug release kinetics showed two stages: a fast-rate early stage dominated by the controlled release of the hydrocortisone adsorbed in the macropores of the reservoir, followed by a slow-rate delivery that we assume is controlled by the hydrocortisone diffusion through the nanopores. It is shown that the release kinetics can be strongly influenced by using different co-additives.
Lopez
Tessy
T
Departamento Atención a la Salud, Universidad Autónoma Metropolitana-Xochimilco, Tlalpan, México DF, México. tessy3@prodigy.net.mx
Ortiz
Emma
E
Alexander-Katz
Roberto
R
Basaldella
Elena
E
Bokhimi
Xim
X
D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D006854:Hydrocortisone / Q000008:administration & dosage*; D007700:Kinetics; D010316:Particle Size; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013499:Surface Properties
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D012822:Silicon Dioxide; D006854:Hydrocortisone