title: Codrugs linking L-dopa and sulfur-containing antioxidants: new pharmacological tools against Parkinson's disease.
abstract: A series of multifunctional codrugs (1-6) were synthesized to overcome the pro-oxidant effect associated with L-dopa (LD) therapy. Target compounds release LD and dopamine (DA) in human plasma after enzymatic hydrolysis, displaying an antioxidant effect superior to that of N-acetylcysteine (NAC). After intracerebroventricular injection of codrug 4, the levels of DA in the striatum were higher than those in LD-treated groups, indicating that this compound has a longer half-life in brain than LD.
authors.affiliation: Dipartimento di Scienze del Farmaco, Universita G. D'Annunzio, Via dei Vestini 31, 66100 Chieti, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Pinnen
authors.forename: Ivana
authors.initials: I
authors.lastname: Cacciatore
authors.forename: Catia
authors.initials: C
authors.lastname: Cornacchia
authors.forename: Piera
authors.initials: P
authors.lastname: Sozio
authors.forename: Laura Serafina
authors.initials: LS
authors.lastname: Cerasa
authors.forename: Antonio
authors.initials: A
authors.lastname: Iannitelli
authors.forename: Cinzia
authors.initials: C
authors.lastname: Nasuti
authors.forename: Franco
authors.initials: F
authors.lastname: Cantalamessa
authors.forename: Durairaj
authors.initials: D
authors.lastname: Sekar
authors.forename: Rosita
authors.initials: R
authors.lastname: Gabbianelli
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Falcioni
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Stefano
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000978:Antiparkinson Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007276:Injections, Intraventricular; D007980:Levodopa / Q000032:analysis*; D010300:Parkinson Disease / Q000188:drug therapy*; D051381:Rats; D013056:Spectrophotometry, Ultraviolet; D013455:Sulfur / Q000032:analysis*
chemical_list: D000975:Antioxidants; D000978:Antiparkinson Agents; D007980:Levodopa; D013455:Sulfur