title: Vitamin A status does not contribute to the residual goiter in schoolchildren of Isfahan, an iodine replenished area.
abstract: Two thousand three hundred and thirty-one schoolchildren were selected by multi-stage random sampling. The thyroid size was estimated by inspection and palpation. The urinary iodine concentration and serum retinol (SR) were measured in 454 and 468 schoolchildren, respectively. Overall, 32.9% of 2,331 children had goiter. The median urinary iodine concentration was 195.5 microg/l. The mean+/-standard deviation of SR in goitrous and non-goitrous children was 34.84+/-7.28 microg/dl and 33.73+/-7.87 microg/dl, respectively (P=0.14). There was no child with vitamin A deficiency (SR <20 microg/dl) in both the goitrous and non-goitrous groups. The prevalence of subjects with low vitamin A status (SR <30 microg/dl) in the goitrous and non-goitrous groups was 27.7% and 33.3%, respectively (P=0.21). In conclusion, the present study reveals that vitamin A deficiency and low vitamin A status are not among the contributing factors of goiter persistence in the studied area, and the role of other responsible factors should be investigated.
authors.affiliation: Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
authors.forename: Mahin
authors.initials: M
authors.lastname: Hashemipour
authors.forename: Ammar H
authors.initials: AH
authors.lastname: Keshteli
authors.forename: Mansour Siavash
authors.initials: MS
authors.lastname: Dastjerdi
authors.forename: Masoud
authors.initials: M
authors.lastname: Amini
authors.forename: Roya
authors.initials: R
authors.lastname: Kelishadi
authors.forename: Navid
authors.initials: N
authors.lastname: Koleini
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000097:blood; D006043:Goiter, Endemic / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency / Q000652:urine; D007492:Iran / Q000453:epidemiology; D007501:Iron / Q000097:blood; D008297:Male; D018673:Nutrition Policy; D009752:Nutritional Status; D009929:Organ Size; D015995:Prevalence; D012720:Severity of Illness Index; D012737:Sex Factors; D017673:Sodium Chloride, Dietary / Q000008:administration & dosage; D013961:Thyroid Gland / Q000033:anatomy & histology; D014801:Vitamin A / Q000097:blood*; D014802:Vitamin A Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D017673:Sodium Chloride, Dietary; C034024:iodized salt; D014801:Vitamin A; D005293:Ferritins; D007455:Iodine; D007501:Iron