title: Evaluation of intracranial aneurysms with 7 T versus 1.5 T time-of-flight MR angiography - initial experience.
abstract: OBJECTIVE
  The purpose of this study was to compare the depiction of intracranial aneurysms by 3D time-of-flight (TOF) magnetic resonance angiography (MRA) at 7 Tesla (T) with the clinical standard TOF MRA at 1.5 T and with digital subtraction angiography (DSA).
  
  
  METHODS
  7 T and 1.5 T TOF MRA images optimized for both field strengths were compared in ten patients with an unruptured intracranial aneurysm. Two blinded neuroradiologists independently rated the image quality of the dome, the neck, and the vessel of origin of all aneurysms in MRA source and maximum intensity projection (MIP) images. DSA was obtained in all subjects and served as reference standard. The mean values of image quality were compared by Wilcoxon signed rank test. In all patients the number and location of the aneurysms was confirmed by DSA.
  
  
  RESULTS
  Both readers identified twelve aneurysms in ten patients in 7 T, 1.5 T TOF MRA and DSA. The image quality of the aneurysm dome was rated higher in 8 of 12 aneurysms and the image quality of the aneurysm neck was superior in 9 of 12 aneurysms at 7 T TOF MRA compared to 1.5 T TOF MRA. The depiction of the parent vessel was graded almost equally by both readers.
  
  
  CONCLUSIONS
  Our initial results indicate that image quality of intracranial aneurysms may benefit from the increased spatial resolution of 7 T TOF MRA compared with 1.5 T TOF MRA. Tailored scan protocols and optimized radiofrequency head coils are needed to further improve the image quality of 7 T TOF MRA.
authors.affiliation: Institut für diagnostische und interventionelle Radiologie und Neuroradiologie, Universitätsklinikum Essen. christoph.moenninghoff@ukessen.de
authors.forename: C
authors.initials: C
authors.lastname: Mönninghoff
authors.forename: S
authors.initials: S
authors.lastname: Maderwald
authors.forename: J M
authors.initials: JM
authors.lastname: Theysohn
authors.forename: O
authors.initials: O
authors.lastname: Kraff
authors.forename: S C
authors.initials: SC
authors.lastname: Ladd
authors.forename: M E
authors.initials: ME
authors.lastname: Ladd
authors.forename: M
authors.initials: M
authors.lastname: Forsting
authors.forename: H H
authors.initials: HH
authors.lastname: Quick
authors.forename: I
authors.initials: I
authors.lastname: Wanke
mesh_terms: D000368:Aged; D015901:Angiography, Digital Subtraction; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D012680:Sensitivity and Specificity