title: [Infective endocarditis due to Bartonella henselae following a rupture of a cerebral aneurysm].
abstract: We report a case of severe aortic bicuspid valve endocarditis, revealed by global cardiac failure without fever, in a 38-year-old man who had developed cerebral mycotic aneurysms nine months earlier. PCR analysis of the excised aortic valve and serological tests (even 9 months earlier) were positive for Bartonella henselae. A combination of intravenous then oral doxycyclin at 200mg/day and intravenous gentamycin at 90mg/day was given for 6 and 2 weeks respectively. The evolution was favorable on follow-up, 12 months after completion of the therapy. Only 49 cases of B. henselae endocarditis have been reported to date, none with associated mycotic aneurysm but most often located on the bicuspid aortic valve, and usually with severe valvular damage due to late diagnosis.
authors.affiliation: Unité des maladies infectieuses, CHU Côte-de-Nacre, avenue Côte-de-Nacre, 14000 Caen, France. delablanchardiere-a@chu-caen.fr
authors.forename: A
authors.initials: A
authors.lastname: de La Blanchardière
authors.forename: P-E
authors.initials: PE
authors.lastname: Fournier
authors.forename: E
authors.initials: E
authors.lastname: Haustraete
authors.forename: D
authors.initials: D
authors.lastname: du Cheyron
authors.forename: O
authors.initials: O
authors.lastname: Lepage
authors.forename: R
authors.initials: R
authors.lastname: Verdon
mesh_terms: D000328:Adult; D016917:Angiomatosis, Bacillary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001021:Aortic Valve; D018416:Bartonella henselae; D004696:Endocarditis / Q000188:drug therapy / Q000209:etiology*; D005839:Gentamicins / Q000627:therapeutic use; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000601:surgery; D008297:Male; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins