Effect of Amblyomma cajennense ticks on the immune response of BALB/c mice and horses.
This work evaluated the effect of the Amblyomma cajennense tick on the immune response of BALB/c mice and on horse lymph node cell proliferation. We observed that mice do not develop resistance to nymphs of this tick species and that lymphocyte proliferation of this host is inhibited by tick saliva, nymphal extract, or infestations. Horse lymph node cell proliferation is inhibited by tick saliva as well. Mice lymphocytes under the effect of tick saliva, nymphal extract, or infestations display a predominantly Th-2 cytokine production pattern. Observed results partially explain this tick's disease vectoring capacity and broad host range.
Castagnolli
Karina Carrão
KC
Universidade Estadual Paulista, Jaboticabal, Brazil.
Ferreira
Beatriz Rossetti
BR
Franzin
Alessandra Mara
AM
de Castro
Márcio Botelho
MB
Szabó
Matias Pablo Juan
MP
D000818:Animals; D049109:Cell Proliferation; D016207:Cytokines / Q000096:biosynthesis; D006736:Horses / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology / Q000378:metabolism; D013987:Ticks / Q000502:physiology*
D016207:Cytokines