Dynamic changes of germinal vesicle chromatin configuration and transcriptional activity during maturation of rabbit follicles.
Dynamic changes in configuration of germinal vesicle (GV) chromatin and their effects on oocyte transcriptional activity and developmental competence were studied in rabbit oocytes. The results indicated that global condensation of GV chromatin, rather than the formation of a perinucleolar ring, would better reflect the global transcriptional repression and developmental competence of oocytes. Gonadotropins, by promoting large-scale chromatin remodeling, regulate oocyte transcriptional activity and developmental competence.
Wang
Hui-Li
HL
College of Animal Science & Veterinary Medicine, Shandong Agricultural University, Tai-an City, People's Republic of China.
Sui
Hong-Shu
HS
Liu
Yong
Y
Miao
De-Qiang
DQ
Lu
Jin-Hua
JH
Liang
Bo
B
Tan
Jing-He
JH
D000818:Animals; D002843:Chromatin / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D054885:Cumulus Cells / Q000502:physiology; D005260:Female; D005498:Follicular Phase / Q000502:physiology; D006062:Gonadotropins / Q000502:physiology; D023421:Models, Animal; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology; D006080:Ovarian Follicle / Q000254:growth & development* / Q000502:physiology; D011817:Rabbits; D014158:Transcription, Genetic / Q000502:physiology*
D002843:Chromatin; D006062:Gonadotropins