title: [Effect of shenshuaining dispersible tablets on the levels of NO, NOS, SOD and MDA in kidney of chronic renal failure rats].
abstract: OBJECTIVE
  To observe the effect of Shenshuaining dispersible tablets on the levels of NO, NOS, SOD and MDA in kidney of chronic renal failure (CRF) rats induced by adenine.
  
  
  METHODS
  Seventy-two Sprague-Dawley rats were randomly divided into 6 groups: normal control group, model control group, Niaoduqing group, Shenshuaining dispersible tablets group(high, middle and low dose). From the second to the sixth group, the rats were prepared for model of CRF by being fed 0.5% adenine. After giving corresponding drugs for 7 weeks, we detected the levels of nitric oxide (NO), total nitric oxide synthase (T-NOS), inducing nitric oxide synthase (iNOS), configuration nitric oxide synthase (cNOS), total superoxide dismutase (SOD), Cu/Zn-SOD and malonaldehyde (MDA) in every rat's kidney tissue.
  
  
  RESULTS
  Compared with normal rats, CRF rats' renal tissue's levels of NO, T-NOS, cNOS, T-SOD and Cu/Zn-SOD markedly decreased. Both the iNOS and MDA contents significantly increased. Shenshuaining dispersible tablets could markedly ameliorate above indexes.
  
  
  CONCLUSIONS
  Shenshuaining dispersible tablets can effectively improve CRF rats' antioxidation effect and reduce damnification of free radical and protect the kidney.
authors.affiliation: Department of Pharmacy, Nanfang Hospital, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Wei
authors.initials: W
authors.lastname: Xiao
authors.forename: Yun
authors.initials: Y
authors.lastname: Ma
authors.forename: Lian-bing
authors.initials: LB
authors.lastname: Hou
mesh_terms: D000225:Adenine; D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*; D013607:Tablets
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C532547:Shenshuaining; D013607:Tablets; D009569:Nitric Oxide; D008315:Malondialdehyde; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D000225:Adenine