From immunity to tolerance through HDAC.
Regulation of expression of the gene encoding interleukin 10 by the histone deacetylase HDAC11 emphasizes the ability of an antigen-presenting cell to induce immunity or tolerance in CD4+ T cells.
Georgopoulos
Katia
K
Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA. katia.georgopoulos@cbrc2.mgh.harvard.edu
D000818:Animals; D000938:Antigen-Presenting Cells / Q000201:enzymology / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D005786:Gene Expression Regulation; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance; D016753:Interleukin-10 / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000502:physiology; D014158:Transcription, Genetic
D016207:Cytokines; D016753:Interleukin-10; C462506:HDAC11 protein, human; D006655:Histone Deacetylases