A bridge to transcription by RNA polymerase.
A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'.
Kaplan
Craig D
CD
Department of Structural Biology, Stanford University, 299 Campus Dr, West, Stanford, CA 94305, USA.
Kornberg
Roger D
RD
D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D014644:Genetic Variation; D014158:Transcription, Genetic
D012321:DNA-Directed RNA Polymerases