Direct preparation of unsymmetrical difunctionalized cyclen derivatives by an Ugi multicomponent reaction.
A new and efficient synthetic protocol for the preparation of unsymmetrical difunctionalized cyclen and its close derivatives using a modified Ugi reaction (N-split Ugi) is described. The scope of this methodology is further extended by the successful use of various isocyanides, highly functionalized carboxylic acids, and aldehydes.
Piersanti
Giovanni
G
Institute of Medicinal Chemistry, University of Urbino Carlo Bo, Piazza del Rinascimento 6, 61029 Urbino (PU), Italy. giovanni.piersanti@uniurb.it
Remi
Francesco
F
Fusi
Vieri
V
Formica
Mauro
M
Giorgi
Luca
L
Zappia
Giovanni
G
D000080027:Cyclams; D003959:Diamines / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D000080027:Cyclams; D003959:Diamines; D006571:Heterocyclic Compounds; C038072:cyclen