Clinicopathologic characteristics of gastrointestinal stromal tumor of the stomach.
OBJECTIVE
This study was undertaken to investigate a surgical role in treating gastrointestinal stromal tumors (GISTs) of the stomach and to find their behavior and prognostic factors.


METHODS
The clinicopathologic results of 112 patients with gastric GISTs who underwent surgery from December 1999 to August 2006 were reviewed.


RESULTS
Forty (35.7%) patients had no symptoms. Of a total of 112 patients, curative resections were performed on 105 (93.8%). There were 41 (36.6%) high-risk patients. The mean follow-up period was 34.3 months (1-82 months) and there were two deaths. Six (5.7%) of the 105 patients who received curative resections had recurrences and all recurrences occurred only in high-risk patients. Univariate analysis showed that tumor size and mitotic count were prognostic for disease-free survival of GIST patients (p=0.0004 and p<0.0001, respectively), but multivariate analysis identified mitotic count as the only prognostic factor for disease-free survival of GIST patients (p=0.039).


CONCLUSIONS
The curative resection rate was high in GISTs of the stomach and they were treated using various surgical procedures. Patient survival after curative resection was good. Mitotic count was the independent prognostic factor for disease-free survival and only high-risk patients had recurrences.
Yang
Han-Kwang
HK
Department of Surgery, Seoul National University College of Medicine, Seoul, Korea.
Park
Do Joong
DJ
Lee
Hyuk-Joon
HJ
Kim
Hyung-Ho
HH
Kim
Woo Ho
WH
Lee
Kuhn Uk
KU
D000328:Adult; D000368:Aged; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D006801:Humans; D000068877:Imatinib Mesylate; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000473:pathology* / Q000601:surgery
D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate