title: Lipid levels: a link between cardiovascular disease and osteoporosis?
abstract: Epidemiological observations support a positive relationship between cardiovascular diseases (CVD) and osteoporosis, where cholesterol has been indicated to be a possible link. Only a few studies have investigated the relation between lipids and BMD, but the association remains unclear. We studied the relationship between serum lipids and BMD of the calcaneus. A cross-sectional population-based study was performed, based on data from the Longitudinal Aging Study Amsterdam, including 620 men and 635 women, 65-88 yr of age. BMD was measured by quantitative ultrasound (QUS), velocity of sound (VOS; m/s), and broadband ultrasound attenuation (BUA; dB/MHz). Models were adjusted for age, body mass index, physical activity, smoking, alcohol, diabetes mellitus, hypertension, testosterone, and 25-hydroxyvitamin D. No association was found between total cholesterol (TC) and QUS. Men and women in the highest quartile of high-density lipoprotein cholesterol (HDL-c) had a significantly lower QUS (men-VOS: beta = -20.8, p = 0.00; BUA: beta = -5.2, p = 0.02; women-VOS: beta = -18.6, p = 0.00) compared with men and women in the lowest quartile. An even stronger positive association was seen between TC/HDL-c ratio and QUS (men-VOS: beta = 21.8, p = 0.00; BUA: beta = 5.5, p = 0.01; women-VOS: beta = 19.2, p = 0.00; BUA: beta = 3.6, p = 0.05). Our analysis shows that the lipid profile that is favorable in the prevention of CVD (i.e., high levels of HDL-c and low TC/HDL-c ratio) is unfavorable for QUS. These results indicate that HDL-c levels do not explain the association between osteoporosis and CVD.
authors.affiliation: Department of Internal Medicine, Section Endocrinology, VU University Medical Centre, Amsterdam, The Netherlands.
authors.forename: Petra J
authors.initials: PJ
authors.lastname: Buizert
authors.forename: Natasja M
authors.initials: NM
authors.lastname: van Schoor
authors.forename: Paul
authors.initials: P
authors.lastname: Lips
authors.forename: Dorly J H
authors.initials: DJ
authors.lastname: Deeg
authors.forename: Elisabeth M
authors.initials: EM
authors.lastname: Eekhoff
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D002318:Cardiovascular Diseases / Q000097:blood*; D015331:Cohort Studies; D015986:Confounding Factors, Epidemiologic; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D010024:Osteoporosis / Q000097:blood*
chemical_list: D008055:Lipids