title: Changes in aac(6')-Ib-cr prevalence and fluoroquinolone resistance in nosocomial isolates of Escherichia coli collected from 1991 through 2005.
abstract: Clinical isolates of Escherichia coli collected from 1991 through 2005 at a tertiary-care center were studied for qnr and aac(6')-Ib-cr genes. Isolates bearing aac(6')-Ib-cr emerged in 1998, coinciding with an increase in ciprofloxacin resistance. The presence of aac(6')-Ib-cr was multiclonal and was associated with the presence of extended-spectrum beta-lactamases.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hadassah-Hebrew University, Jerusalem 91120, Israel.
authors.forename: Gabriela
authors.initials: G
authors.lastname: Warburg
authors.forename: Maya
authors.initials: M
authors.lastname: Korem
authors.forename: Ari
authors.initials: A
authors.lastname: Robicsek
authors.forename: Dalia
authors.initials: D
authors.lastname: Engelstein
authors.forename: Allon E
authors.initials: AE
authors.lastname: Moses
authors.forename: Colin
authors.initials: C
authors.lastname: Block
authors.forename: Jacob
authors.initials: J
authors.lastname: Strahilevitz
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000235:genetics*; D024881:Drug Resistance, Bacterial; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology / Q000382:microbiology; D024841:Fluoroquinolones / Q000494:pharmacology; D005798:Genes, Bacterial; D017408:Guidelines as Topic; D006801:Humans; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D012189:Retrospective Studies; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D001618:beta-Lactamases