Motional coherence in fluid phospholipid membranes.
We report a high energy-resolution neutron backscattering study, combined with in situ diffraction, to investigate slow molecular motions on nanosecond time scales in the fluid phase of phospholipid bilayers of 1,2-dimyristoyl-sn-glycero-3-phoshatidylcholine. A cooperative structural relaxation process was observed. From the in-plane scattering vector dependence of the relaxation rates in hydrogenated and deuterated samples, combined with results from a 0.1 micros long all-atom molecular dynamics simulation, it is concluded that correlated dynamics in lipid membranes occurs over several lipid distances, spanning a time interval from pico- to nanoseconds.
Rheinstädter
Maikel C
MC
Department of Physics and Astronomy, University of Missouri-Columbia, Columbia, Missouri 65211, USA. RheinstadterM@missouri.edu
Das
Jhuma
J
Flenner
Elijah J
EJ
Brüning
Beate
B
Seydel
Tilo
T
Kosztin
Ioan
I
D003198:Computer Simulation; D003903:Deuterium; D004134:Dimyristoylphosphatidylcholine / Q000031:analogs & derivatives / Q000737:chemistry; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D008566:Membranes / Q000737:chemistry; D008956:Models, Chemical; D033363:Neutron Diffraction / Q000379:methods; D010743:Phospholipids / Q000737:chemistry*
D008051:Lipid Bilayers; D010743:Phospholipids; D003903:Deuterium; D004134:Dimyristoylphosphatidylcholine