[Effect of the amount of portal blood stasis removal on endotoxemia and liver function after liver transplantation].
OBJECTIVE
To investigate the influence of the amount of portal blood stasis removal on endotoxemia and liver function after liver transplantation.


METHODS
Forty-seven patients who received liver transplantation from February 2006 to November 2007 were divided into 2 groups according to the amount of portal blood stasis removal during operation: group A (n = 26) 50 ml and group B (n = 21) 200 ml of portal blood stasis removal respectively. The levels of plasma endotoxin, D-lactate, tumor necrosis factor-alpha, interleukin-6, liver function and blood coagulation were examined and analyzed.


RESULTS
Under the condition of no significant difference in sex, age, primary liver diseases and Child-pugh's classification, cold ischemic time, total operation and anhepatic time, operation methods, volume of blood loss and transfusion, and all preoperative observations. Most of observations showed the restoration of the patients in group B was better than that in group A. The plasma levels of endotoxin, D-lactate, tumor necrosis factor-alpha, interleukin-6, alanine aminotransferase, aspartate aminotransferase, prothrombin time and activated partial thromboplastin time in group B were significantly lower than those in group A (P < 0.05). The level of plasma prealbumin in group B was significantly higher than that in group A (P < 0.05).


CONCLUSIONS
The removal of 200 ml portal blood stasis leads to a better results than that of 50 ml, and it can help alleviate endotoxemia and facilitate the restoration of the liver function after liver transplantation.
Wang
Ye
Y
Department of Hepatobiliary Surgery, Haici Hospital of Qingdao University, Qingdao 266033, China.
Yang
Jia-mei
JM
Hu
Ming-hua
MH
Li
Dian-qi
DQ
Niu
Wen-yang
WY
Liu
Peng
P
Hou
Yuan-kai
YK
Wu
Meng-chao
MC
D000328:Adult; D000368:Aged; D001815:Bloodletting / Q000379:methods*; D019446:Endotoxemia / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008099:Liver / Q000503:physiopathology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000601:surgery*; D011183:Postoperative Complications / Q000517:prevention & control; D015427:Reperfusion Injury / Q000517:prevention & control