title: The combination of low-dose levobupivacaine and fentanyl for spinal anaesthesia in ambulatory inguinal herniorrhaphy.
abstract: This study investigated whether the addition of 25 microg intrathecal fentanyl to levobupivacaine spinal anaesthesia for outpatient inguinal herniorrhaphy allows a sub-anaesthetic levobupivacaine dose to be used. Forty patients were assigned to receive 5 mg levobupivacaine 0.5% mixed with 25 microg fentanyl (group LF) or 7.5 mg levobupivacaine 0.5% (group L). The highest sensory block levels achieved were T7 (range T5 - T9) and T6 (range T4 - T9) in groups LF and L, respectively. The times to two-segment regression, S2 regression, ambulation, urination and discharge were all significantly shorter in group LF than group L. These results indicate that, for outpatient inguinal herniorrhaphy, intrathecal fentanyl combined with low-dose levobupivacaine provides good quality spinal anaesthesia and minimizes the need for intra-operative analgesia. This protocol is well suited for the outpatient setting because it features rapid recovery of full motor power, sensory function and bladder function.
authors.affiliation: Department of Anaesthesiology and Reanimation, Faculty of Medicine, Uludag University, Bursa, Turkey. nkelebek@uludag.edu.tr
authors.forename: N K
authors.initials: NK
authors.lastname: Girgin
authors.forename: A
authors.initials: A
authors.lastname: Gurbet
authors.forename: G
authors.initials: G
authors.lastname: Turker
authors.forename: T
authors.initials: T
authors.lastname: Bulut
authors.forename: S
authors.initials: S
authors.lastname: Demir
authors.forename: N
authors.initials: N
authors.lastname: Kilic
authors.forename: A
authors.initials: A
authors.lastname: Cinar
mesh_terms: D000759:Adjuvants, Anesthesia; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000775:Anesthesia, Spinal / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002045:Bupivacaine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005283:Fentanyl; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D000077554:Levobupivacaine; D008297:Male; D010351:Patient Discharge / Q000706:statistics & numerical data; D011446:Prospective Studies; D020127:Recovery of Function
chemical_list: D000759:Adjuvants, Anesthesia; D000779:Anesthetics, Local; D004338:Drug Combinations; D000077554:Levobupivacaine; D005283:Fentanyl; D002045:Bupivacaine