title: Secretome of animal trypanosomes.
abstract: Animal trypanosomosis is one of the most severe constraints to agricultural development in sub-Saharan Africa and is also an important disease of livestock in Latin America and Asia. The causative agents are various species of protozoan parasites belonging to the genus Trypanosoma, among which T. congolense and T. evansi are the major pathogenic species. The extracellular position of trypanosomes obliges us to consider both the parasite and its excreted/secreted factors in the course of the physiopathologic process. The advent of proteomics led us to propose a comparative approach of the proteome (i.e., the whole parasite content) and the secretome (i.e., naturally excreted/secreted molecules) of T. congolense and T. evansi with particular attention to common and specific molecules between strains of differing virulence and pathogenicity. The molecular identification of differentially expressed trypanosome molecules correlated with either the virulence process or the pathogenicity will provide new potential molecular targets for improved field diagnosis and chemotherapy of animal trypanosomosis.
authors.affiliation: CIRAD UMR [UMR 177IRD-CIRAD], Montpellier, France. philippe.holzmuller@cirad.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Holzmuller
authors.forename: Pascal
authors.initials: P
authors.lastname: Grébaut
authors.forename: Jean-Benoît
authors.initials: JB
authors.lastname: Peltier
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Brizard
authors.forename: Trina
authors.initials: T
authors.lastname: Perrone
authors.forename: Marisa
authors.initials: M
authors.lastname: Gonzatti
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Bengaly
authors.forename: Michel
authors.initials: M
authors.lastname: Rossignol
authors.forename: Pedro María
authors.initials: PM
authors.lastname: Aso
authors.forename: Philippe
authors.initials: P
authors.lastname: Vincendeau
authors.forename: Gérard
authors.initials: G
authors.lastname: Cuny
authors.forename: Alain
authors.initials: A
authors.lastname: Boulangé
authors.forename: Roger
authors.initials: R
authors.lastname: Frutos
mesh_terms: D000818:Animals; D040901:Proteomics; D051381:Rats; D011923:Rats, Nude; D013045:Species Specificity; D014345:Trypanosoma / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence