The new role of calcimimetics as vasculotropic agents.
The discovery of the calcium-sensing receptor (CaSR) and the development of calcimimetics have provided new insights into calcium homeostasis and new therapeutic opportunities for parathyroid-related disorders. However, the CaSR is also implicated in various other cellular processes, and the translational applications of calcimimetics may not be exclusively calcium-centric. Koleganova et al. describe a novel role for calcimimetics as vasculotropes, which provides the impetus for further studies to characterize their effects on vascular biology.
Al-Aly
Ziyad
Z
Division of Nephrology, Saint Louis Veterans Affairs Medical Center, Saint Louis, Missouri, USA.
D000814:Aniline Compounds / Q000627:therapeutic use; D002114:Calcinosis / Q000150:complications / Q000188:drug therapy* / Q000517:prevention & control; D002118:Calcium / Q000819:agonists*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D000069449:Cinacalcet; D006801:Humans; D009281:Naphthalenes / Q000627:therapeutic use; D010627:Phenethylamines; D011437:Propylamines; D044169:Receptors, Calcium-Sensing / Q000187:drug effects
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