Chiral guanidine catalyzed enantioselective reactions.
Chiral guanidine catalysts share common characteristics such as high pK(a) values and dual hydrogen-bonding modes of activation, and high catalytic activities and enantioselectivities can often be achieved. The utilization of guanidines as catalysts has been growing at a steady pace. In the past few years, it has attracted tremendous attention through several landmark achievements. This article highlights the development of chiral guanidine catalysis in asymmetric synthesis.
Leow
Dasheng
D
Department of Chemistry, National University of Singapore, 3 Science Drive 3, 117543, Singapore.
Tan
Choon-Hong
CH
D002384:Catalysis; D006146:Guanidines / Q000737:chemistry*; D006860:Hydrogen Bonding; D008956:Models, Chemical; D013237:Stereoisomerism
D006146:Guanidines