title: Rhodium-catalyzed direct oxidative carbonylation of aromatic C-H bond with CO and alcohols.
abstract: A general protocol for the rhodium-catalyzed oxidative carbonylation of arenes to form esters has been developed. A broad substrate scope has been demonstrated allowing carbonylation of electron-rich, electron-poor, and heterocyclic arenes, and the reaction shows wide functional group tolerance and excellent regioselectivities. Up to 96% yield of ortho-substituted aryl or heteroaryl carboxylic esters were obtained with this methodology. The possible mechanism for the rhodium-catalyzed oxidative carbonylation reaction was proposed in this article. Studies show that Oxone play an important role in the transformation.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Zheng-Hui
authors.initials: ZH
authors.lastname: Guan
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Ren
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Spinella
authors.forename: Shichao
authors.initials: S
authors.lastname: Yu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
authors.forename: Xumu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D001555:Benzene Derivatives / Q000737:chemistry*; D001565:Benzoates / Q000138:chemical synthesis* / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry*; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry; D013464:Sulfuric Acids / Q000737:chemistry
chemical_list: D000438:Alcohols; D001555:Benzene Derivatives; D001565:Benzoates; D004952:Esters; D013464:Sulfuric Acids; D002248:Carbon Monoxide; D012238:Rhodium; C048813:potassium peroxymonosulfuric acid