title: Rational use of antimicrobials in dentistry during pregnancy.
abstract: The use of medicines during pregnancy deserves special attention from dentists due to the potential risks to fetal development. The prescription of antimicrobial drugs during this period must be based not only on the etiology of the disease but also on the drug's effect on the embryo, which may be toxic, possibly leading to irreversible lesions. Interest in studies of the teratogenic effects of drugs increased in response to reports of the high incidence of phocomelia in patients treated with thalidomide. Although teratogenicity has long been known, pregnant women today are still exposed to this risk. The effects of drugs depend on the level of susceptibility of the fetus and on the period of exposure during pregnancy. In this context, and considering the paucity of studies on this subject in dentistry, the aim of this review was to offer an up-to-date compilation of data on the antimicrobial drugs most frequently used during pregnancy and the effects of their use.
authors.affiliation: Oral Biopatology Program, São José dos Campos Dental School São Paulo State University, Brasil.
authors.forename: Karina Bortolin
authors.initials: KB
authors.lastname: Lodi
authors.forename: Luis Felipe das Chagas e Silva de
authors.initials: LF
authors.lastname: Carvalho
authors.forename: Cristiane Yumi
authors.initials: CY
authors.lastname: Koga-Ito
authors.forename: Valéria Abrantes Pinheiro
authors.initials: VA
authors.lastname: Carvalho
authors.forename: Rosilene Fernandes da
authors.initials: RF
authors.lastname: Rocha
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003813:Dentistry; D004363:Drug Utilization / Q000592:standards; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents