Nucleobase mediated, photocatalytic vesicle formation from an ester precursor.
We report the use of photoinduced electron transfer to drive reductive cleavage of an ester to produce bilayer-forming molecules; specifically, visible photolysis in a mixture of a decanoic acid ester precursor, hydrogen donor molecules, and a ruthenium-based photocatalyst that employs a linked nucleobase (8-oxo-guanine) as an electron donor generates decanoic acid. The overall transformation of the ester precursor to yield vesicles represents the use of an external energy source to convert nonstructure forming molecules into amphiphiles that spontaneously assemble into vesicles. The core of our chemical reaction system uses an 8-oxo-G-Ru photocatalyst, a derivative of [tris(2,2'-bipyridine)-Ru(II)](2+).
DeClue
Michael S
MS
MDRNA Inc., Bothell, WA 98021, USA.
Monnard
Pierre-Alain
PA
Bailey
James A
JA
Maurer
Sarah E
SE
Collis
Gavin E
GE
Ziock
Hans-Joachim
HJ
Rasmussen
Steen
S
Boncella
James M
JM