Protection against Asiatic Taenia solium induced by a recombinant 45W-4B protein.
Taenia solium is a great threat not only to human health but also to the pig-raising industry. Oncospheral stage-specific 45W proteins are good candidates for the development of anticysticercosis vaccines. In this study, a recombinant 45W-4B protein was highly produced and used for vaccination. Two animal trials resulted in a significant reduction in parasite burden induced by the definite protein against Asiatic T. solium, up to 97.0% and 98.4%, respectively. These provide informative results for the development of effective 45W-4B vaccines against cysticercosis caused by both Chinese and Mexican T. solium isolates and even by other isolates.
Luo
Xuenong
X
Key Laboratory of Zoonoses of CAAS, Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
Zheng
Yadong
Y
Hou
Junling
J
Zhang
Shaohua
S
Cai
Xuepeng
X
D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D002681:China; D003551:Cysticercosis / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*
D000947:Antigens, Helminth