Byrsonima fagifolia Niedenzu Apolar Compounds with Antitubercular Activity.
Bioassay-guided fractionation of the chloroform extract of Byrsonima fagifolia leaves led to the isolation of active antitubercular compounds alkane dotriacontane (Minimal Inhibitory Concentration-MIC, 62.5 μg mL(-1)), triterpenoids as bassic acid (MIC = 2.5 μg mL(-1)), α-amyrin acetate (MIC = 62.5 μg mL(-1)), a mixture of lupeol, α- and β-amyrin (MIC = 31.5 μg mL(-1)) and a mixture of lupeol, and acetates of α- and β-amyrin (MIC = 31.5 μg mL(-1)). The antimycobacterial activity was determined by the Microplate Alamar Blue Assay (MABA) and the structures of promising compounds were determined by spectroscopic analysis. This investigation constitutes the first report of a chemical and antitubercular study of apolar compounds from B. fagifolia Niedenzu (IK).
Higuchi
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Unesp, Universidade Estadual Paulista, Faculdade de Ciências Farmacêuticas, Rodovia Araraquara-Jaú km 01, CEP 14801-902, Araraquara-SP, Brazil.
Sannomiya
M
M
Pavan
F R
FR
Leite
S R A
SR
Sato
D N
DN
Franzblau
S G
SG
Sacramento
L V S
LV
Vilegas
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W
Leite
C Q F
CQ