title: [Nephrotic syndrom with focal and segmental glomerulosclerosis in Dakar: epidemiological and clinicopathological characteristics (about 134 cases)].
abstract: Focal and segmental glomerulosclerosis (FSGS) is common and non-specific patterns of glomerular injury encountered in human renal biopsies. Cortico-resistant nephrotic syndrome is the main manifestation. We report epidemiological, clinical and pathological aspects of FSGS in Dakar. We report the results of a retrospective study about focal segmental glomerulosclerosis (FSGS) identified from 258 kidney biopsies performed in the medical clinic 1 of A. Le Dantec hospital from January 1993 to December 2003. FSG is found in 134 cases (52%), membranous glomerulonephritis in 32 cases (12,4%), minimal change disease in 20 cases (7.7%). Ninety eigths files were exploitable. FSGS has male gender predominance with a sex ratio of 3. Median age of patients is 28 years (15 and 79 years). Symptomatology is dominated by oedema in 86 cases (87,7%), hypertension in 12 cases (12.2%), hematuria in 5 cases (5.1%), nephrotic proteinuria in 65 cases (66,3%) and no nephrotic proteinuria in 33 cases (33.6%), renal failure in 25 cases (25%)and leucocyturia in 18 cases (18%). FSGS involving more than 50% of glomeruli is encountered in 41 cases (42%), severe interstitial fibrosis is associated in 26 cases. Different pathological aspects are: classical FSGS in 88 cases (88.7%), FSGS " collapsing" in 7 cases (7.1%), FSG "tip-lesion" in one case, FSGS associated to membranous glomerulosclerosis in 2 cases and to diabetic glomerulosclerosis in one case. FSGS is primitive in 88 cases (89,8%) and secondary in 10 cases (10.2%). FSGS is the most common primitive glomerulopathy in Dakar. Nephrotic syndrome is the main manifestation of this disease. Collapsing FSGS is not correlated with the HIV Infection.
authors.affiliation: Service de Néphrologie, CHU A. Le Dantec, Dakar, Sénégal. niangabdou@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Niang
authors.forename: C
authors.initials: C
authors.lastname: Dial
authors.forename: E F
authors.initials: EF
authors.lastname: Ka
authors.forename: A
authors.initials: A
authors.lastname: Lèye
authors.forename: A
authors.initials: A
authors.lastname: Pouye
authors.forename: M M
authors.initials: MM
authors.lastname: Ka
authors.forename: M
authors.initials: M
authors.lastname: Mbengue
authors.forename: D
authors.initials: D
authors.lastname: Droz
authors.forename: B
authors.initials: B
authors.lastname: Diouf
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001706:Biopsy; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000473:pathology; D005923:Glomerulosclerosis, Focal Segmental / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009402:Nephrosis, Lipoid / Q000473:pathology; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D011507:Proteinuria / Q000175:diagnosis; D012189:Retrospective Studies; D012675:Senegal / Q000453:epidemiology; D012737:Sex Factors