Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report.
BACKGROUND
The granulocyte-colony stimulating factor-producing tumor was first reported in 1977, however, anaplastic pleomorphic type carcinoma of the pancreas producing granulocyte-colony stimulating factor is still rare.


METHODS
A 63-year-old man was admitted to our hospital with body weight loss (-10 kg during months) and upper abdominal pain from 3 weeks. Abdominal computed tomography demonstrated a pancreatic tumor 10 cm in size and multiple low-density areas in the liver. On admission, the peripheral leukocyte count was elevated to 91,500/mm3 and the serum concentration of granulocyte-colony stimulating factor was 134 pg/mL (normal, < 18.1 pg/mL). Based on liver biopsy findings, the tumor was classified as an anaplastic pleomorphic-type carcinoma. Immunohistochemical staining showed that pancreatic carcinoma cells were positive for granulocyte-colony stimulating factor. The patient developed interstitial pneumonia, probably caused by granulocyte-colony stimulating factor, and died 11 days after admission.


CONCLUSIONS
This is a rare case report of anaplastic pleomorphic-type carcinoma of the pancreas producing granulocyte-colony stimulating factor and confirmed by immunohistochemistry.
Nakajima
Atsushi
A
Gastroenterology Division, Yokohama City University Hospital, Kanazawa-ku Yokohama, Japan.nakajima-tky@umin.ac.jp
Takahashi
Hirokazu
H
Inamori
Masahiko
M
Abe
Yasunobu
Y
Kobayashi
Noritoshi
N
Kubota
Kensuke
K
Yamanaka
Shoji
S