IFNalpha-induced recurrence of Graves' disease ten years after thyroidectomy in chronic viral hepatitis C. Case report.
In contrast to chronic or subacute thyroiditis, Graves' disease rarely complicates IFN-alpha therapy for chronic viral C hepatitis. We report the case of a 51-year-old man in whom IFN-alpha treatment was followed by recurrence of Graves' disease 10 years after thyroidectomy was performed and the patient was declared cured. Despite severe thyrotoxicosis, combined IFN-alpha and ribavirin therapy was continued and radioiodine treatment was considered for Graves' disease.
Duncea
Ileana
I
Endocrinology Department, "Iuliu Hatieganu" University of Medicine and Pharmacy, Endocrinology Clinic 3-5, Luis Pasteur Str, 400349 Cluj-Napoca, Romania. c_e_georgescu@yahoo.com
Pepene
Carmen E
CE
D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D006111:Graves Disease / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000517:prevention & control; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000097:blood / Q000139:chemically induced / Q000175:diagnosis / Q000517:prevention & control; D013972:Thyrotropin / Q000097:blood / Q000187:drug effects; D013974:Thyroxine / Q000097:blood / Q000187:drug effects
D000998:Antiviral Agents; D016898:Interferon-alpha; D012254:Ribavirin; D013972:Thyrotropin; D013974:Thyroxine