title: [Clinical, radiological and pathological exploration of focal nodular hyperplasia of liver reported in Korea].
abstract: OBJECTIVE
  Focal nodular hyperplasia (FNH) is mandatory to be differentiated from other hepatic tumorous conditions such as hepatocellular carcinoma and adenoma. The purpose of this study was to explore the clinical, radiological and pathological features of FNH cases reported in Korea.
  
  
  METHODS
  We have searched the journals from the web site "http://koreamed.org" using keywords "focal nodular hyperplasia" and "liver" - total of 38 cases of FNH, 37 cases from 17 published articles and one case from our experience confirmed histologically, were reviewed and analyzed.
  
  
  RESULTS
  Thirty eight cases were diagnosed between gestational age of 36 weeks and 67 years. Seventeen female patients (45%) had no history of taking oral contraceptives. Twenty cases (52.6%) experienced clinical symptoms such as abdominal pain and palpable mass. Computed tomography revealed contrast-enhancement in 34 nodules (85%) and typical central stellate scar in 9 (22.5%) of 40 nodules. Magnetic resonance imaging showed T1 weighted low signal in 18 (60%) and T2 weighted high signal in 22 (73.3%) of 30 nodules. Six (60%) of 10 cases showed hypervascular staining on hepatic angiography. Among 38 cases, 32 (84.2%) cases had single nodule and their mean size was 3.9 cm (0.5-16 cm). Pathologically, fibrous septa, proliferation of bile ductules and arterial wall thickening were seen in most cases.
  
  
  CONCLUSIONS
  Of all the FNH cases reported in Korea, there were some differences in clinical aspects of sex ratio, accompanying clinical symptoms, and relationship with oral contraceptives, compared with previous reports. Further prospective studies are needed by means of nation-wide clinical survey and analysis.
authors.affiliation: Department of Internal Medicine, Dankook University College of Medicine, Cheonan, Korea.
authors.forename: Ha Yan
authors.initials: HY
authors.lastname: Kang
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: La
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Kong
authors.forename: Sang Seok
authors.initials: SS
authors.lastname: Lee
authors.forename: Doo San
authors.initials: DS
authors.lastname: Baek
authors.forename: Sang Soo
authors.initials: SS
authors.lastname: Lim
authors.forename: Ki Chul
authors.initials: KC
authors.lastname: Shin
authors.forename: Hyun Duk
authors.initials: HD
authors.lastname: Shin
authors.forename: Se Young
authors.initials: SY
authors.lastname: Yun
authors.forename: Suk Bae
authors.initials: SB
authors.lastname: Kim
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Shin
authors.forename: Hong Ja
authors.initials: HJ
authors.lastname: Kim
authors.forename: Il Han
authors.initials: IH
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003276:Contraceptives, Oral; D005260:Female; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014057:Tomography, X-Ray Computed
chemical_list: D003276:Contraceptives, Oral