title: Oxygen sensors at the crossroad of metabolism.
abstract: Aerobic organisms developed mechanisms to protect themselves against a shortage of oxygen (O(2)). Recent studies reveal that O(2) sensors, belonging to the novel class of 2-oxoglutarate dependent iron(ii)-dioxygenases, have more important roles in metabolism than anticipated. Here, we provide a "metabolo-centric" overview of the role of the PHD/FIH members of this family in metabolism, in particular on how they regulate O(2) supply and consumption, energy compensation and conservation, O(2) conformance and hypoxia tolerance, redox and pH homeostasis, and other vital metabolic processes with implications in health and disease. These insights may offer novel opportunities for the treatment of ischemic diseases.
authors.affiliation: Vesalius Research Center, K.U. Leuven, Leuven, B-3000, Belgium.
authors.forename: Julián
authors.initials: J
authors.lastname: Aragonés
authors.forename: Peter
authors.initials: P
authors.lastname: Fraisl
authors.forename: Myriam
authors.initials: M
authors.lastname: Baes
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D007511:Ischemia / Q000209:etiology; D051379:Mice; D010101:Oxygen Consumption; D010105:Oxygenases / Q000378:metabolism*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D005227:Fatty Acids; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010105:Oxygenases; C433124:iron(II) oxygenase; D011393:Procollagen-Proline Dioxygenase; D005947:Glucose