title: Quantifying the risk of neurodegenerative disease in idiopathic REM sleep behavior disorder.
abstract: OBJECTIVE
  Idiopathic REM sleep behavior disorder (RBD) is a potential preclinical marker for the development of neurodegenerative diseases, particularly Parkinson disease (PD) and Lewy body dementia. However, the long-term risk of developing neurodegeneration in patients with idiopathic RBD has not been established. Obtaining an accurate picture of this risk is essential for counseling patients and for development of potential neuroprotective therapies.
  
  
  METHODS
  We conducted a follow-up study of all patients seen at the sleep disorders laboratory at the Hôpital du Sacré Coeur with a diagnosis of idiopathic RBD. Diagnoses of parkinsonism and dementia were defined according to standard criteria. Survival curves were constructed to estimate the 5-, 10-, and 12-year risk of developing neurodegenerative disease.
  
  
  RESULTS
  Of 113 patients, 93 (82%) met inclusion criteria. The mean age of participants was 65.4 years and 75 patients (80.4%) were men. Over the follow-up period, 26/93 patients developed a neurodegenerative disorder. A total of 14 patients developed PD, 7 developed Lewy body dementia, 4 developed dementia that met clinical criteria for AD, and 1 developed multiple system atrophy. The estimated 5-year risk of neurodegenerative disease was 17.7%, the 10-year risk was 40.6%, and the 12-year risk was 52.4%.
  
  
  CONCLUSIONS
  Although we have found a slightly lower risk than other reports, the risk of developing neurodegenerative disease in idiopathic REM sleep behavior disorder is substantial, with the majority of patients developing Parkinson disease and Lewy body dementia.
authors.affiliation: Department of Neurology, L7-305 Montreal General Hospital, 1650 Cedar Ave., Montreal, Quebec, Canada. ronald.postuma@mcgill.ca
authors.forename: R B
authors.initials: RB
authors.lastname: Postuma
authors.forename: J F
authors.initials: JF
authors.lastname: Gagnon
authors.forename: M
authors.initials: M
authors.lastname: Vendette
authors.forename: M L
authors.initials: ML
authors.lastname: Fantini
authors.forename: J
authors.initials: J
authors.lastname: Massicotte-Marquez
authors.forename: J
authors.initials: J
authors.lastname: Montplaisir
mesh_terms: D000368:Aged; D003704:Dementia / Q000453:epidemiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020961:Lewy Body Disease / Q000453:epidemiology; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000453:epidemiology; D019636:Neurodegenerative Diseases / Q000453:epidemiology* / Q000209:etiology* / Q000523:psychology; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000453:epidemiology*; D017286:Polysomnography; D011569:Psychiatric Status Rating Scales; D020187:REM Sleep Behavior Disorder / Q000150:complications* / Q000453:epidemiology* / Q000523:psychology; D012306:Risk; D016019:Survival Analysis