title: The impact of direct-to-consumer marketing of cancer genetic testing on women according to their genetic risk.
abstract: OBJECTIVE
  To assess the impact of direct-to-consumer marketing for genetic testing among women of varying genetic risk for breast and ovarian cancer.
  
  
  METHODS
  Telephone surveys were conducted with 315 women in Denver, Colorado, one target audience for the Myriad BRACAnalysis ad campaign. Genetic risk was determined from personal and family history and grouped by probability of having a BRCA1/2 mutation (low <5%, moderate 5-<10%, high > or =10%).
  
  
  RESULTS
  High-risk women were more knowledgeable about BRACAnalysis and more likely to recall the media ads than were low-risk women (60 vs. 39%, P < 0.01). After seeing the ads, about 40% of women were more interested in testing and about 10% expressed increased worry about developing breast or ovarian cancer. Women across all risk groups overstated the benefits and appropriateness of testing. An equal percentage of high- and low-risk women (51 and 60%) felt that they would benefit from genetic testing.
  
  
  CONCLUSIONS
  The campaign effectively reached a large audience. Concern about breast cancer was not appreciably increased. A large percentage of low-risk women (not candidates for testing) expressed interest in testing, suggesting the campaign was too broad. A campaign targeted at high-risk women, who may benefit from testing might be preferred.
authors.affiliation: Department of Epidemiology, Colorado School of Public Health-Denver, Aurora, Colorado 80045-0508, USA. Jan.Lowery@ucdenver.edu
authors.forename: Jan T
authors.initials: JT
authors.lastname: Lowery
authors.forename: Tim
authors.initials: T
authors.lastname: Byers
authors.forename: Lisen
authors.initials: L
authors.lastname: Axell
authors.forename: Lisa
authors.initials: L
authors.lastname: Ku
authors.forename: Jillian
authors.initials: J
authors.lastname: Jacobellis
mesh_terms: D000328:Adult; D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000523:psychology*; D003120:Colorado; D054626:Consumer Health Information / Q000379:methods; D005260:Female; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000523:psychology*; D006293:Health Promotion; D006801:Humans; D008389:Marketing of Health Services; D008875:Middle Aged; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000523:psychology*; D012306:Risk; D014930:Women / Q000193:education
chemical_list: D019313:BRCA1 Protein