title: Prostate adenocarcinoma presenting with supraclavicular node enlargement: report of a case.
abstract: This report describes a case of prostate adenocarcinoma presenting with supraclavicular adenopathy and deep venous thrombosis in the ipsilateral arm. Biopsy revealed the enlarged node to be an undifferentiated adenocarcinoma of unknown origin, while CT scan evidenced widespread adenopathies. Because of the increase in serum PSA, the immunohistochemical staining of the biopsy specimen was reviewed and strong positivity for PSA suggested a prostatic origin. We emphasize the importance of PSA immunohistochemistry and serum PSA level monitoring in men presenting with carcinoma of undetermined origin and generalized lymphadenopathies.
authors.affiliation: Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Platania
authors.forename: Emilio
authors.initials: E
authors.lastname: Bajetta
authors.forename: Valentina
authors.initials: V
authors.lastname: Guadalupi
authors.forename: Roberto
authors.initials: R
authors.lastname: Buzzoni
authors.forename: Maurizio
authors.initials: M
authors.lastname: Colecchia
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000276:immunology / Q000556:secondary; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000097:blood; D001706:Biopsy; D002968:Clavicle; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D017430:Prostate-Specific Antigen / Q000032:analysis* / Q000097:blood; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen