Comparison of a cytokine adsorbing column and an endotoxin absorbing column for the treatment of experimental endotoxemia.
The present study compared the effects of direct hemoperfusion (DHP) using a cytokine absorbing (CTR) column with those using an endotoxin absorbing (PMX) column with endotoxin-induced shock in rats. Thirty-six rats were injected intravenously with endotoxin (15 mg/kg), and then allocated into one of the following three groups: control group, treated without CTR; PMX group, treated with a PMX column for 120 min; CTR group, treated with a CTR column for 120 min. The present study showed that CTR treatment decreased the mortality rate 8h after endotoxin injection and inhibited inflammatory responses (cytokine, hemodynamics and acidosis) similar to PMX treatment.
Taniguchi
Takumi
T
Department of Emergency and Critical Care Medicine, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan. takutaniyan@yahoo.co.jp
Kurita
Akihide
A
Yamamoto
Ken
K
Inaba
Hideo
H
D000042:Absorption; D000818:Animals; D016207:Cytokines; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000139:chemically induced / Q000628:therapy*; D004731:Endotoxins / Q000633:toxicity*; D006464:Hemoperfusion / Q000295:instrumentation* / Q000379:methods; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D016207:Cytokines; D004731:Endotoxins