Therapeutic DNA vaccine against Trypanosoma cruzi infection in dogs.
Chagas' disease is an important health problem in most Latin American countries, and a concern in dog populations, which act as a reservoir. We showed in previous studies that a therapeutic DNA vaccine could partially control the pathology after Trypanosoma cruzi infection in mice, and this vaccine may represent an alternative treatment for Chagas' disease. Here we evaluated the therapeutic efficacy of this vaccine in experimentally infected dogs for up to 2 months after infection. Our results suggest that DNA vaccine treatment may affect the immune response and delay Chagas' disease progression in T. cruzi-infected dogs, and confirm the potential of this novel treatment.
Quijano-Hernandez
Israel Alejandro
IA
Laboratorio de Parasitología, Centro de Investigaciones Regionales "Hideyo Noguchi," Universidad Autónoma de Yucatan, Mérida, Yucatan, México.
Bolio-González
Manuel Emilio
ME
Rodríguez-Buenfil
Jorge Carlos
JC
Ramirez-Sierra
María Jesus
MJ
Dumonteil
Eric
E
D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D004797:Enzyme-Linked Immunosorbent Assay; D014349:Trypanosoma cruzi / Q000472:pathogenicity*; D014352:Trypanosomiasis / Q000469:parasitology / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D019444:Vaccines, DNA / Q000627:therapeutic use*
D019444:Vaccines, DNA