title: [Cardiac manifestations in Sjogren syndrome].
abstract: OBJECTIVE
  To analyze the cardiac manifestations of patients with primary and secondary Sjogren syndrome.
  
  
  METHODS
  Clinical data (clinical manifestations, serologic measurements, echocardiogram) of 396 patients with Sjogren syndrome who admitted to our hospital from 2004--2007 were retrospectively analyzed. Patients with congenital, rheumatic and coronary heart diseases, hypertension and diabetes (n = 221) and patients with incomplete clinic data (n = 51) were excluded.
  
  
  RESULTS
  A total of 124 cases were included in this analysis (mean age 47.4 years old; 5 males; average disease duration 85.5 months). Cardiac involvement in Sjogren syndrome is usually asymptomatic. Pericardial effusion (PE) were evidenced in 20.2%, left ventricular diastolic dysfunction (LVDD) in 13.7%, pulmonary artery hypertension (PAH) in 12.9%, left atrium enlargement/in 7.3%, mitral insufficiency in 4.8%, aortic dilation in 5.6%, tricuspid insufficiency in 3.2%, left ventricular enlargement in 2.4% and left ventricular systolic dysfunction in 0.8% patients by echocardiography examinations. Patients with PE had significantly lower CH50, C3, C4 levels and significantly higher C reactive protein level (CRP) and SSA positive rate than patients without PE (all P < 0.05). The serum level of CRP was significantly associated with PE (OR 0.976, 95% CI 0.956 - 0.997, P < 0.05). Age is positively correlated to LVDD (OR 0.884, 95% CI 0.811 - 0.964, P < 0.005). The gammaglobulin level is significantly higher in the PAH group than that in the non-PAH group (P < 0.05).
  
  
  CONCLUSIONS
  Cardiac involvement is not rare in patients with Sjogren syndrome. PE, LVDD and PAH are usual cardiac manifestations in these patients. The serum level of CRP is positively related to PE in these patients with Sjogren syndrome.
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China.
authors.forename: Yi-cong
authors.initials: YC
authors.lastname: Ye
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Zhu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zeng
authors.forename: Shu-yang
authors.initials: SY
authors.lastname: Zhang
authors.forename: Quan
authors.initials: Q
authors.lastname: Fang
authors.forename: Xiao-meng
authors.initials: XM
authors.lastname: Li
mesh_terms: D000328:Adult; D018618:Echocardiography, Doppler, Color; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010490:Pericardial Effusion / Q000000981:diagnostic imaging / Q000209:etiology*; D012189:Retrospective Studies; D012859:Sjogren's Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology*