Antileprosy activity and preliminary toxicological characteristics of some dialkyldithiocarbamate derivatives.
Antileprosy activity of dialkyldithiocarbamate derivatives was studied in experiments on mice infected with M. leprae into paw pads. We found that 2-diethyldithiocarbamoyl-3-cyano-5-nitropyridine is the most promising antileprosy agent; it effectively suppresses multiplication of M. leprae and is well tolerated under conditions of chronic animal experiment.
Urlyapova
N G
NG
Institute of Leprosy Research, Federal Agency for Health Care and Social Development Health, Astrakhan, Russia. niil@astmail.astranet.ru
Yuschenko
A A
AA
Daudova
A D
AD
Makarov
V A
VA
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007917:Leprostatic Agents / Q000097:blood / Q000627:therapeutic use*; D007918:Leprosy / Q000097:blood / Q000188:drug therapy* / Q000401:mortality / Q000662:veterinary; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D050296:Microbial Viability / Q000187:drug effects; D009166:Mycobacterium leprae / Q000187:drug effects / Q000502:physiology; D013859:Thiocarbamates / Q000097:blood / Q000737:chemistry / Q000627:therapeutic use*; D016896:Treatment Outcome
D007917:Leprostatic Agents; D013859:Thiocarbamates