title: How do mesenchymal stromal cells exert their therapeutic benefit?
abstract: In recent years mesenchymal stromal cells (MSC) have emerged as a major new form of cell therapy. While the original perception was that MSC were stem/progenitor cells with the potential to contribute to the regeneration of tissue, more recent data suggest that the principal mechanism of MSC activity is through the release of soluble mediators that elicit the observed biologic response. Future studies are needed to identify more completely the spectrum of therapeutic applications and delineate better the associated molecular and cellular mechanisms.
authors.affiliation: Division of Oncology/Blood and Marrow Transplantation, The Children's Hospital of Philadelphia and The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. horwitze@email.chop.edu
authors.forename: E M
authors.initials: EM
authors.lastname: Horwitz
authors.forename: M
authors.initials: M
authors.lastname: Dominici
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism*; D006086:Graft vs Host Disease / Q000628:therapy*; D048091:Guided Tissue Regeneration / Q000639:trends; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000639:trends; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000473:pathology; D010013:Osteogenesis Imperfecta / Q000628:therapy*
chemical_list: D016207:Cytokines