[Color Doppler and contrast-enhanced ultrasonography for assessment of vascular perfusion in porcine liver allografts with acute graft rejection].
OBJECTIVE
To investigate the feasibility of evaluating hepatic blood perfusion after liver transplantation using color Doppler and contrast-enhanced ultrasonography and the diagnostic value of hepatic blood perfusion for acute graft rejection.


METHODS
In this before-after study with quantitative analysis, contrast-enhanced sonography was performed with simultaneous liver function monitoring in porcine models of allograft liver transplantation before and after the operation.


RESULTS
In pigs with acute graft rejection, the AUC decreased significantly after transplantation as compared with that of non-rejection transplant group (F=11.069, P=0.011), but the parameters including A, Alpha, C, t(0), DPI, or TTP showed no significant differences between the two groups.


CONCLUSIONS
Pulse-inversion contrast harmonic imaging combined with acoustic quantitative technology can be an efficient means for evaluating blood perfusion in the liver allograft, and the TIC obtained using this method possesses high values for quantitative evaluation of liver allograft rejection.
Wang
Qian
Q
Department of Ultrasound, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Gong
Wei-bing
WB
Xie
Jin-ming
JM
Sun
Yu
Y
Yuan
Ying
Y
D000818:Animals; D003287:Contrast Media; D005260:Female; D005466:Fluorocarbons; D006084:Graft Rejection / Q000000981:diagnostic imaging*; D007089:Image Enhancement; D008099:Liver / Q000098:blood supply*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D010477:Perfusion; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature; D014184:Transplantation, Homologous; D018615:Ultrasonography, Doppler, Color / Q000379:methods
D003287:Contrast Media; D005466:Fluorocarbons; C042852:perflutren