Reversing neurodevelopmental disorders in adults.
Abnormalities in brain development, thought to be irreversible in adults, have long been assumed to underlie the neurological and psychiatric symptoms associated with neurodevelopmental disorders. Surprisingly, a number of recent animal model studies of neurodevelopmental disorders demonstrate that reversing the underlying molecular deficits can result in substantial improvements in function even if treatments are started in adulthood. These findings mark a paradigmatic change in the way we understand and envision treating neurodevelopmental disorders.
Ehninger
Dan
D
Department of Neurobiology, Psychiatry and Biobehavioral Sciences, Psychology and the Brain Research Institute, University of California Los Angeles, Los Angeles, CA 90095-1761, USA.
Li
Weidong
W
Fox
Kevin
K
Stryker
Michael P
MP
Silva
Alcino J
AJ
D000818:Animals; D001921:Brain / Q000002:abnormalities*; D001927:Brain Diseases / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*