title: Ecthyma gangrenosum: an important feature of pseudomonal sepsis in a previously well child.
abstract: Ecthyma gangrenosum is a rare, distinctive skin disorder associated with potentially fatal underlying pseudomonal sepsis. Although typically occurring in neutropenic or immunocompromised patients, it can occasionally affect healthy children. The appearances are characteristic with small indurated vesicular papules progressing rapidly to infarcted necrotic areas with surrounding erythema and a typical black eschar. In young children, these are often accompanied by fever and diarrhoea. The absence of suppuration and slough distinguishes it from the more recognized pyoderma gangrenosum. Lesions can occur at any site although are most commonly found over the buttocks, limbs, axillae and perineum. We describe the case of a 28-month-old, previously well child who presented with typical features of ecthyma gangrenosum secondary to Pseudomonas infection who responded to appropriate antibiotic treatment. Despite a thorough search, no underlying cause was found. Early recognition and prompt treatment with antipseudomonal antibiotics is vital to reduce morbidity and potential mortality.
authors.affiliation: Department of Dermatology, King's College Hospital, Denmark Hill, London, UK. sachagoolamali@yahoo.co.uk
authors.forename: S I
authors.initials: SI
authors.lastname: Goolamali
authors.forename: A
authors.initials: A
authors.lastname: Fogo
authors.forename: L
authors.initials: L
authors.lastname: Killian
authors.forename: H
authors.initials: H
authors.lastname: Shaikh
authors.forename: N
authors.initials: N
authors.lastname: Brathwaite
authors.forename: M
authors.initials: M
authors.lastname: Ford-Adams
authors.forename: S
authors.initials: S
authors.lastname: Macfarlane
mesh_terms: D002675:Child, Preschool; D004473:Ecthyma / Q000382:microbiology* / Q000473:pathology; D005260:Female; D005734:Gangrene; D006801:Humans; D011552:Pseudomonas Infections / Q000150:complications* / Q000473:pathology; D018805:Sepsis / Q000150:complications*; D017192:Skin Diseases, Bacterial / Q000382:microbiology* / Q000473:pathology