title: Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features.
abstract: An adolescent with idiopathic CD4 lymphocytopenia suffered from 4 visceral leishmaniasis relapses despite appropriate treatment. CD8 lymphocytopenia and abnormal expansion of TCRalphabeta, CD4, CD8 cells were consistently detected together with reduced export of mature T cells from thymus. This novel form of idiopathic CD4 lymphocytopenia may predispose to multiple visceral leishmaniasis relapses.
authors.affiliation: G.Gaslini Scientific Institute, Genova, Italy. ignaziaprigione@ospedale-gaslini.ge.it
authors.forename: Ignazia
authors.initials: I
authors.lastname: Prigione
authors.forename: Elio
authors.initials: E
authors.lastname: Castagnola
authors.forename: Luisa
authors.initials: L
authors.lastname: Imberti
authors.forename: Claudio
authors.initials: C
authors.lastname: Gambini
authors.forename: Luigi
authors.initials: L
authors.lastname: Gradoni
authors.forename: Umberto
authors.initials: U
authors.lastname: Dianzani
authors.forename: Ugo
authors.initials: U
authors.lastname: Ramenghi
authors.forename: Francesca
authors.initials: F
authors.lastname: Giacopelli
authors.forename: Alessandro
authors.initials: A
authors.lastname: Moretta
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Moretta
authors.forename: Alessandro
authors.initials: A
authors.lastname: Plebani
authors.forename: Alain
authors.initials: A
authors.lastname: Fischer
authors.forename: Vito
authors.initials: V
authors.lastname: Pistoia
mesh_terms: D000293:Adolescent; D000493:Allopurinol / Q000627:therapeutic use; D000666:Amphotericin B / Q000627:therapeutic use; D000982:Antipruritics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007633:Keratins / Q000378:metabolism; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D008198:Lymph Nodes / Q000473:pathology; D012008:Recurrence; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications* / Q000276:immunology
chemical_list: D000982:Antipruritics; C068538:liposomal amphotericin B; D000493:Allopurinol; D007633:Keratins; D000666:Amphotericin B