title: Possible impact of inflammatory status on C-telopeptide pyridinoline cross-links of type I collagen and osteocalcin levels around oral implants with peri-implantitis: a controlled clinical trial.
abstract: Detection of progression level of peri-implantitis may help in the prevention of oral implant failure. C-telopeptide pyridinoline crosslinks of Type I collagen (ICTP) and osteocalcin (OC) are specific markers of bone turnover and bone degradation. Determination of the ICTP and OC levels in the peri-implant sulcus fluid (PISF) may predict the metabolic and/or inflammatory changes in the peri-implant bone. The aim of this clinical study was to evaluate ICTP and OC levels in the PISF for oral implants with and without peri-implant bone destruction and correlate these levels with the traditional clinical peri-implant parameters (probing depth, plaque index, gingival index and gingival bleeding time index) and radiographic bone level measurements. Fifteen patients with 30 peri-implant sites with bone destruction (radiographic bone loss) and health were included. Clinical parameters were measured and PISF was collected from the sites. Peri-implant sulcus fluid ICTP and OC levels were detected by radioimmunoassay technique from PISF samples. All clinical parameters demonstrated a significant increase in peri-implantitis sites compared with healthy sites. The PISF volume of the peri-implantitis sites was also significantly higher than of the healthy peri-implant sites. Although not statistically significant, a trend of increase was demonstrated in ICTP PISF samples sampled from peri-implantitis sites compared with healthy sites. A significant increase was noticed for OC PISF level in peri-implantitis sites compared with healthy ones. As well as peri-implant clinical measurements, volumetric changes at PISF may be counted as an important clinical parameter to distinguish the bone destruction sites from healthy sites around oral implants.
authors.affiliation: Department of Oral Surgery, Faculty of Dentistry, Hacettepe University, Ankara, Turkey.
authors.forename: C
authors.initials: C
authors.lastname: Tümer
authors.forename: Y
authors.initials: Y
authors.lastname: Aksoy
authors.forename: G N
authors.initials: GN
authors.lastname: Güncü
authors.forename: R M
authors.initials: RM
authors.lastname: Nohutcu
authors.forename: K
authors.initials: K
authors.lastname: Kilinc
authors.forename: T F
authors.initials: TF
authors.lastname: Tözüm
mesh_terms: D000328:Adult; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D024042:Collagen Type I / Q000378:metabolism*; D003758:Dental Implantation, Endosseous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D015675:Osteocalcin / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D010518:Periodontitis / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism*; D011859:Radiography
chemical_list: D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin