Bursting into the nucleus.
An increase in extracellular Ca(2+) induces the nuclear localization of the Crz1 transcription factor and the activation of target genes in yeast. A recent study indicates that nuclear entry occurs in short stochastic bursts that are unsynchronized within the population of cells. The frequency but not the amplitude of the bursts is controlled by Ca(2+). Modulation of the frequency of the burst coordinates aspects of expression of Crz target genes.
Crabtree
Gerald R
GR
Stanford University Medical School, Stanford, CA 94305, USA.
Graef
Isabella A
IA
D021581:Active Transport, Cell Nucleus; D002118:Calcium / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D015966:Gene Expression Regulation, Fungal; D005800:Genes, Fungal; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology; D015003:Yeasts / Q000235:genetics
C109868:CRZ1 protein, S cerevisiae; D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D002118:Calcium