Oral lesions in Saudi renal transplant patients.
Renal transplantation has evolved as the best treatment option for patients with end-stage renal disease. Different oral problems arise in these patients, either as a direct consequence of drug-induced immunosuppression or pharmacokinetics. To determine the prevalence of intra-oral lesions in a group of medically stable Saudi renal transplant patients (RTP) and to identify possible risk factors, in comparison with age and sex-matched healthy control subjects (HCS), we studied 58 RTP and 52 HCS. All subjects had a thorough oral examination and oral lesions were diagnosed according to the clinically accepted criteria. Gingival overgrowth (GO), erythematous candidiasis (EC) and hairy leukoplakia (HL) were diagnosed in RTP with prevalence of 74.1%, 15.5%, and 8.6%, respectively. The severity of the gingival overgrowth significantly correlated with the use of cyclosporine and nifedipine combination therapy, serum cyclosporine, and serum creatinine level. In conclusions, the finding of our study strongly propose that RTP should undergo routine and regular comprehensive oral examination, and any suspicious lesion must be investigate and treated.
Al-Mohaya
Maha Ali
MA
Oral Medicine Clinic, Riyadh Armed Forces Hospital, Riyadh, Saudi Arabia. mmohaya@hotmail.com
Darwazeh
Azmi Mohammad-Ghaleb
AM
Bin-Salih
Salih
S
Al-Khudair
Waleed
W
D000293:Adolescent; D000328:Adult; D002121:Calcium Channel Blockers / Q000009:adverse effects; D002180:Candidiasis, Oral / Q000209:etiology; D016572:Cyclosporine / Q000009:adverse effects; D005260:Female; D019214:Gingival Overgrowth / Q000209:etiology; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D017733:Leukoplakia, Hairy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000453:epidemiology / Q000209:etiology*; D009910:Oral Hygiene; D015995:Prevalence; D012529:Saudi Arabia / Q000453:epidemiology
D002121:Calcium Channel Blockers; D016572:Cyclosporine