Mechanical model of neural tissue displacement during Lorentz effect imaging.
Allen Song and coworkers recently proposed a method for MRI detection of biocurrents in nerves called "Lorentz effect imaging." When exposed to a magnetic field, neural currents are subjected to a Lorentz force that moves the nerve. If the displacement is large enough, an artifact is predicted in the MR signal. In this work, the displacement of a nerve of radius a in a surrounding tissue of radius b and shear modulus mu is analyzed. The nerve carries a current density J and lies in a magnetic field B. The solution to the resulting elasticity problem indicates that the nerve moves a distance BJ/4mu a2ln(b/a). Using realistic parameters for a human median nerve in a 4T field, this calculated displacement is 0.013 microm or less. The distribution of displacement is widespread throughout the tissue, and is not localized near the nerve. This displacement is orders of magnitude too small to be detected by conventional MRI methods.
Roth
Bradley J
BJ
Department of Physics, Oakland University, Rochester, Michigan 48309, USA. roth@oakland.edu
Basser
Peter J
PJ
D000200:Action Potentials / Q000502:physiology*; D000465:Algorithms; D001696:Biomechanical Phenomena; D003198:Computer Simulation; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical