title: Core promoters are predicted by their distinct physicochemical properties in the genome of Plasmodium falciparum.
abstract: Little is known about the structure and distinguishing features of core promoters in Plasmodium falciparum. In this work, we describe the first method to computationally identify core promoters in this AT-rich genome. This prediction algorithm uses solely DNA physicochemical properties as descriptors. Our results add to a growing body of evidence that a physicochemical code for eukaryotic genomes plays a crucial role in core promoter recognition.
authors.affiliation: Dipartimento di Malattie Infettive, Parassitarie ed Immunomediate - Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy. kevbrick@gmail.com
authors.forename: Kevin
authors.initials: K
authors.lastname: Brick
authors.forename: Junichi
authors.initials: J
authors.lastname: Watanabe
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Pizzi
mesh_terms: D000465:Algorithms; D000818:Animals; D001482:Base Composition; D018503:Genome, Protozoan; D010963:Plasmodium falciparum / Q000235:genetics*; D011401:Promoter Regions, Genetic