title: White cell count and C-reactive protein measurement in patients with possible appendicitis.
abstract: BACKGROUND
  Clinical assessment outweighs the use of investigations in the diagnosis of acute appendicitis. Nevertheless, white cell count (WCC) and C-reactive protein (CRP) are regularly measured in patients with suspected appendicitis. The aim of this study was to assess the utility of these markers in patients presenting with acute lower abdominal pain.
  
  
  METHODS
  WCC and CRP were measured prospectively in 98 patients presenting with lower abdominal pain, and the results were correlated with each patient's outcome.
  
  
  RESULTS
  No patients with WCC and CRP both in the normal range had acute appendicitis. Raised WCC and CRP were poor positive predictors of appendicitis, both alone and in combination, and correlated poorly with the development of complications.
  
  
  CONCLUSIONS
  This result may have important clinical and economic implications. We suggest that patients experiencing lower abdominal pain, with normal WCC and CRP values, are unlikely to have acute appendicitis and can be safely sent home.
authors.affiliation: Department of General Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK. anshusengupta@doctors.org.uk
authors.forename: Anshuman
authors.initials: A
authors.lastname: Sengupta
authors.forename: George
authors.initials: G
authors.lastname: Bax
authors.forename: Simon
authors.initials: S
authors.lastname: Paterson-Brown
mesh_terms: D000208:Acute Disease; D001064:Appendicitis / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007958:Leukocyte Count / Q000379:methods*; D008297:Male; D011446:Prospective Studies
chemical_list: D002097:C-Reactive Protein