Impact of antiovarian antibodies (AOA) on ovarian responsiveness in vitro fertilization and embryo transfer.
OBJECTIVE
This study was to investigate the effects of antiovarian antibodies (AOA) on ovarian responsiveness in vitro fertilization and embryo transfer (IVF/ET).


METHODS
233 infertility women younger than 36 years undergone IVF/ET because of single salpingemphraxis were attended in the study, whose fast blood was taken to detect serum AOA by ELISA. Among them there were 35 women with serum AOA positive composed the study group and the other with serum AOA negative composed the control. Ovarian volume, antral follicle number, basal FSH, gonadotropin dosage and recollected oocytes were compared between the 2 groups.


RESULTS
There's no difference in ovarian volume between serum AOA positive group with negative group, P>0.05. The number of antral follicles was less and basal FSH was higher in AOA positive group than in control, P<0.05; what's more, the ampoules of gonadotrophin consumed in AOA positive group exceed significantly in control, and less recollected oocytes in AOA positive group than in control, P<0.01. Of the 233 infertility women, the serum AOA positive rate was 73.08% in the women who got less than 5 recollected oocytes, significantly higher than the other women in the study, P<0.01.


CONCLUSIONS
The existing of anti-ovarian antibodies had suppressive effects on the ovarian responsiveness in ovarian stimulation in IVF/ET cycle and on ovarian function. AOA should be detected before IVF/ET to evaluate ovarian responsiveness and further treatment seems necessary.
Zou
Shu-Hua
SH
Center for Reproductive Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China. zzsshh87516@yahoo.com.cn
Zhang
Peng
P
Song
Dong-Po
DP
Li
Bo
B
Wu
Rui-Ying
RY
D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000276:immunology* / Q000628:therapy; D010053:Ovary / Q000276:immunology*; D010060:Ovulation / Q000276:immunology*; D027724:Reproductive Techniques, Assisted; D055815:Young Adult
D001323:Autoantibodies; D005640:Follicle Stimulating Hormone