title: [Prognostic factors for 72 patients with osteosarcoma of the extremity treated with neoadjuvant chemotherapy].
abstract: OBJECTIVE
  To determine the prognostic factors that influence survival of patients with non-metastatic, high-grade osteosarcoma of the extremities.
  
  
  METHODS
  The data of 72 patients treated between June 2003 and June 2007, was retrospectively evaluated in relation to many factors including gender, age, etc.
  
  
  RESULTS
  Tumor necrosis was significantly related to gender, tumor volume change, tumor margin and T2 signal intensity of the extraosseous component of bone sarcomas. Multivariate analysis, tumor necrosis was only related to tumor volume change. Upon multivariate analysis, good histologic response was related to the outcome of patients.
  
  
  CONCLUSIONS
  Event free survival is related to the tumor necrosis, the level of alkaline phosphatase and the change of T2 signal of the extraosseous component. Tumor necrosis is related to the volume change after preoperative chemotherapy. These factors must be considered when deciding risk-adapted treatments for patients with osteosarcoma.
authors.affiliation: Department of Orthopedic Oncology, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Guo
authors.forename: Rong-li
authors.initials: RL
authors.lastname: Yang
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Tang
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome