Impact of different low-dose ritonavir regimens on lipids, CD36, and adipophilin expression.
We investigated the relationship between ritonavir concentrations and changes in lipids, vascular inflammation markers, CD36, and adipophilin expression in volunteers randomly assigned to groups receiving 100 mg of ritonavir once daily or twice daily. In both groups decreases in high-density lipoprotein (HDL) (6%, P = 0.010; and 10%, P < 0.001, respectively) and CD36 (14%, P = 0.012; and 16%, P = 0.006, respectively) and increases in the vascular inflammation marker sCD40L (12%, P = 0.008; 19%, P = 0.003, respectively) were seen. Increases in adipophilin (30%, P = 0.044) and triglycerides (32%, P = 0.044) were seen only in the group receiving ritonavir twice daily. The ritonavir concentration in the plasma correlated with changes in triglycerides, HDL, and adipophilin (r = 0.34, P = 0.030; r = 0.33, P = 0.040; and r = 0.4, P = 0.01, respectively).
Collot-Teixeira
S
S
1Cardiovascular Division, King's College London, London, UK.
De Lorenzo
F
F
Waters
L
L
Fletcher
C
C
Back
D
D
Mandalia
S
S
Pozniak
A
A
Yilmaz
S
S
McGregor
J L
JL
Gazzard
B
B
Boffito
M
M
D000328:Adult; D018955:CD36 Antigens / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D008297:Male; D008565:Membrane Proteins; D008875:Middle Aged; D010455:Peptides / Q000097:blood / Q000235:genetics*; D000070780:Perilipin-2; D019438:Ritonavir / Q000008:administration & dosage* / Q000097:blood; D055815:Young Adult
D018955:CD36 Antigens; D008055:Lipids; D008565:Membrane Proteins; C000602982:PLIN2 protein, human; D010455:Peptides; D000070780:Perilipin-2; D019438:Ritonavir