Bronchopulmonary disposition of micafungin in healthy adult volunteers.
By way of bronchoscopy and bronchoalveolar lavage, intrapulmonary steady-state concentrations of micafungin administered at 150 mg daily to 15 healthy volunteers were determined at 4, 12, and 24 h after the third dose. The micafungin disposition was predominantly intracellular, with approximately 106% penetration into alveolar macrophages and 5% penetration into epithelial lining fluid.
Nicasio
Anthony M
AM
Center for Anti-Infective Research and Development, Hartford Hospital, Hartford, Connecticut 06102, USA.
Tessier
Pamela R
PR
Nicolau
David P
DP
Knauft
R Fredrick
RF
Russomanno
John
J
Shore
Eric
E
Kuti
Joseph L
JL
D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D001806:Blood Urea Nitrogen; D001980:Bronchi / Q000378:metabolism*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D001999:Bronchoscopy; D017321:Clinical Trials, Phase I as Topic; D054714:Echinocandins / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008168:Lung / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000378:metabolism; D000077551:Micafungin; D008875:Middle Aged; D011446:Prospective Studies; D011650:Pulmonary Alveoli / Q000378:metabolism
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin