title: Inhibition of Lux quorum-sensing system by synthetic N-acyl-L-homoserine lactone analogous.
abstract: In the present study, we investigated the inhibition of the Lux quorum-sensing system by N-acyl cyclopentylamine (Cn-CPA). The Lux quorum-sensing system regulates luminescence gene expression in Vibrio fischeri. We have already reported on the synthesis of Cn-CPA and their abilities as inhibitors of the quorum-sensing systems in Pseudomonas aeruginosa and Serratia marcescens. In the case of Pseudomonas aeruginosa (Las and Rhl quorum-sensing system) and Serratia marcescens (Spn quorum-sensing system), specific Cn-CPA with a particular acyl chain length showed the strongest inhibitory effect. In the case of the Lux quorum-sensing system, it was found that several kinds of Cn-CPA with a range from C5 to C10 showed similar strong inhibitory effects. Moreover, the inhibitory effect of Cn-CPA on the Lux quorum-sensing system was stronger than that of halogenated furanone, a natural quorum-sensing inhibitor.
authors.affiliation: Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi, Japan.
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Wang
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Morohoshi
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ikeda
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D048908:Aliivibrio fischeri / Q000235:genetics*; D005798:Genes, Bacterial; D049449:Luminescence; D053038:Quorum Sensing / Q000187:drug effects*
chemical_list: C088386:homoserine lactone; D015107:4-Butyrolactone