title: Nickel-catalyzed oxidative coupling reactions of two different terminal alkynes using O(2) as the oxidant at room temperature: facile syntheses of unsymmetric 1,3-diynes.
abstract: Two different terminal alkynes now can be coupled together in the presence of NiCl(2).6H(2)O/CuI by using an excess of one of the terminal alkyne substrates. The new method employed 20 mol % TMEDA as the ligand and environmentally benign O(2) or air as the oxidant. It is the first example using Ni-salt as catalyst by employing air or O(2) as oxidant, which led to efficient heterocoupling of two different alkynes.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, PR China.
authors.forename: Weiyan
authors.initials: W
authors.lastname: Yin
authors.forename: Chuan
authors.initials: C
authors.lastname: He
authors.forename: Mao
authors.initials: M
authors.lastname: Chen
authors.forename: Heng
authors.initials: H
authors.lastname: Zhang
authors.forename: Aiwen
authors.initials: A
authors.lastname: Lei
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry; D053280:Diynes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000480:Alkynes; D053280:Diynes; D003300:Copper; D009532:Nickel