[Detection of gene mutations of SCN5A in 7 patients with Brugada syndrome].
OBJECTIVE
Brugada syndrome is linked to sodium channel mutations and could induce arrhythmias that even lead to sudden death. The purpose of this study was to detect if there was gene mutation of SCN5A in 7 patients with Brugada syndrome and explore the molecular genetic characteristics of this disease.


METHODS
Genomic DNA was extracted from peripheral blood of all 7 patients with Brugada syndrome and 41 pairs of PCR primers were designed to amplify all the 28 exons of SCN5A.


RESULTS
There was no novel mutation in exons of Gene SCN5A in these patients with Brugada syndrome.


CONCLUSIONS
Brugada syndrome might associated gene mutation or other mechanisms independent of SCN5A gene mutation.
Yuan
Bin-bin
BB
Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Shan
Qi-jun
QJ
Yang
Bing
B
Chen
Ming-long
ML
Zou
Jian-gang
JG
Chen
Chun
C
Xu
Dong-jie
DJ
Cao
Ke-jiang
KJ
D000328:Adult; D053840:Brugada Syndrome / Q000235:genetics*; D004252:DNA Mutational Analysis; D005091:Exons; D006801:Humans; D008297:Male; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics*; D009154:Mutation; D062554:NAV1.5 Voltage-Gated Sodium Channel; D015222:Sodium Channels / Q000235:genetics*
D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels