Myxotyrosides A and B, Unusual rhamnosides from Myxococcus sp.
Myxobacteria are gliding bacteria of the delta-subdivision of the Proteobacteria and known for their unique biosynthetic capabilities. Two examples of a new class of metabolites, myxotyrosides A (1) and B (2), were isolated from a Myxococcus sp. The myxotyrosides have a tyrosine-derived core structure glycosylated with rhamnose and acylated with unusual fatty acids such as (Z)-15-methyl-2-hexadecenoic and (Z)-2-hexadecenoic acid. The fatty acid profile of the investigated Myxococcus sp. (strain 131) is that of a typical myxobacterium with a high similarity to those described for M. fulvus and M. xanthus, with significant concentrations of neither 15-methyl-2-hexadecenoic acid nor 2-hexadecenoic acid being detected.
Ohlendorf
Birgit
B
Institute of Pharmaceutical Biology, UniVersity of Bonn, Nussallee 6, D-53115 Bonn, Germany.
Lorenzen
Wolfram
W
Kehraus
Stefan
S
Krick
Anja
A
Bode
Helge B
HB
König
Gabriele M
GM
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001410:Bacillus megaterium / Q000187:drug effects; D002708:Chlorella / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004926:Escherichia coli / Q000187:drug effects; D055325:Eurotium / Q000187:drug effects; D005227:Fatty Acids / Q000235:genetics; D008401:Gas Chromatography-Mass Spectrometry; D006017:Glycolipids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D016940:Myxococcus / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D016958:Pseudomonas putida / Q000187:drug effects; D053038:Quorum Sensing; D012210:Rhamnose / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D005227:Fatty Acids; D006017:Glycolipids; C535044:myxotyroside A; C535045:myxotyroside B; D012210:Rhamnose