title: L-valine production during growth of pyruvate dehydrogenase complex-deficient Corynebacterium glutamicum in the presence of ethanol or by inactivation of the transcriptional regulator SugR.
abstract: Pyruvate dehydrogenase complex-deficient strains of Corynebacterium glutamicum produce L-valine from glucose only after depletion of the acetate required for growth. Here we show that inactivation of the DeoR-type transcriptional regulator SugR or replacement of acetate by ethanol already in course of the growth phase results in efficient L-valine production.
authors.affiliation: Institute of Microbiology and Biotechnology, University of Ulm, 89069 Ulm, Germany.
authors.forename: Bastian
authors.initials: B
authors.lastname: Blombach
authors.forename: Annette
authors.initials: A
authors.lastname: Arndt
authors.forename: Marc
authors.initials: M
authors.lastname: Auchter
authors.forename: Bernhard J
authors.initials: BJ
authors.lastname: Eikmanns
mesh_terms: D048230:Corynebacterium glutamicum / Q000201:enzymology* / Q000235:genetics / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism*; D055786:Gene Knockout Techniques; D011768:Pyruvate Dehydrogenase Complex / Q000235:genetics* / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics*; D014633:Valine / Q000096:biosynthesis*
chemical_list: D011768:Pyruvate Dehydrogenase Complex; D014157:Transcription Factors; D000431:Ethanol; D014633:Valine