title: Effect of induction chemotherapy on speech and swallowing function in patients with oral tongue cancer.
abstract: BACKGROUND
  Swallowing physiology, diet, and patient-reported outcomes were evaluated after induction chemotherapy for oral tongue cancer.
  
  
  METHODS
  Fifteen of 23 patients enrolled in a phase II clinical trial of induction chemotherapy followed by surgical resection for oral tongue cancer underwent instrumental and perceptual analysis of speech and swallowing. Oropharyngeal swallow efficiency (OPSE) was calculated. Patient-reported outcomes were collected. We compared pre- and postchemotherapy results.
  
  
  RESULTS
  OPSE scores were not significantly different (p > .05) after induction chemotherapy; however, patient-reported swallowing and diet levels were significantly higher (p < .001 and p = .015, respectively). Diet levels improved from soft-chewable to full diet in most patients. Speech intelligibility did not change (p = .328).
  
  
  CONCLUSIONS
  It appears that induction chemotherapy has a negligible effect on speech and swallowing physiology but may provide symptomatic improvement of pain and swallowing after treatment. Further investigations are needed to corroborate these findings.
authors.affiliation: Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Denise A
authors.initials: DA
authors.lastname: Barringer
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Hutcheson
authors.forename: Erich M
authors.initials: EM
authors.lastname: Sturgis
authors.forename: Merrill S
authors.initials: MS
authors.lastname: Kies
authors.forename: Jan S
authors.initials: JS
authors.lastname: Lewin
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001466:Barium Sulfate; D016190:Carboplatin / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000601:surgery; D003287:Contrast Media; D003679:Deglutition / Q000502:physiology*; D004032:Diet; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011446:Prospective Studies; D011788:Quality of Life; D013065:Speech Intelligibility / Q000502:physiology*; D013068:Speech Production Measurement; D011795:Surveys and Questionnaires; D014062:Tongue Neoplasms / Q000188:drug therapy* / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D001466:Barium Sulfate; D016190:Carboplatin