Mechanism of the iron-mediated alkene aziridination reaction: experimental and computational investigations.
Combined experimental and computational studies suggest that the iron-mediated aziridination of cis-1-phenylpropene proceeds along two mechanistic pathways that share a common imidoiron(IV) intermediate. One pathway involves a second species, proposed to be an azametallacyclobutane intermediate, which collapses to provide the syn-aziridine product. A second, parallel pathway is responsible for the formation of an anti-aziridine.
Klotz
Katie L
KL
Department of Chemistry, University of Wisconsin-Eau Claire, 105 Garfield Avenue, Eau Claire, Wisconsin 54702, USA.
Slominski
Luke M
LM
Riemer
Miranda E
ME
Phillips
James A
JA
Halfen
Jason A
JA