[Expression and activity of membrane surface tissue factor in peripheral blood cells of patients with cerebral infarction].
This study was aimed to investigate the expression and activity of membrane surface tissue factor (TF) of monocytes and platelets in peripheral blood cells from patients with cerebral infarction and their clinical significance. The TF expressions in monocytes and platelets from 25 patients with cerebral infarction were detected by flow cytometry, the TF activity was detected by chromogenic reaction method, and compared with 24 normal people used as control. The results showed that the TF expressions of monocytes and platelets in peripheral blood cells from patients with cerebral infarction were significantly higher than that in normal controls (p<0.01), and TF activity was also higher in patients than that in controls (p<0.01). In conclusion, the expression and activity of membrane surface in patients with cerebral infarction were enhanced, the hematocyte-derived tissue factor as a trigger in coagulation pathway is involved in pathological thrombosis in patients with cerebral infarction.
Huang
Xi-Lian
XL
Department of Hemotology, Hangzhou First People Hospital, Hangzhou 31006, Zhejiang Province, China.
Qian
Shen-Xian
SX
Cao
Li-Hong
LH
Liu
Li-Rong
LR
Tan
Jun-Feng
JF
Shi
Peng-Fei
PF
Gao
Da-Quan
DQ
Xie
Ya-Ping
YP
D000368:Aged; D001773:Blood Cells / Q000378:metabolism; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood / Q000378:metabolism*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism*
D013925:Thromboplastin