title: [Von Willebrand disease and menorrhagia].
abstract: BACKGROUND
  Known since over than seventy years, von willebrand disaese is the most common herediary bleeding disorder. This condition was first described by Pr. Willebrand in 1926 in a family with (positive) history of excesive bleeding tendency. Von Willebrand desease is characterized by a lifelong tendency toward easy spontaneous mucosal or post operative bleeding. In females, excessive or prolonged menorrhagia could be a sign of von willebrand desease; symptoms that are often misunderstood to be gynecologic rather than hematologic problem. In the present work, we have tried to screen for this anomaly in females with menorrhagia, following a simple anamnestic, clinical and biological protocol.
  
  
  METHODS
  In a seventeen month study, fifty two procreating females with menorrhagia were recruited in the haematology laboratory of Aristide le Dantec hospital with the cooperation of gynecology and obstetric departements of Aristide Le Dantec, Abass Ndao and grand yoff Hospitals.
  
  
  RESULTS
  Eight patients were revealed to be von willebrand positive (prevalence: 15%). The diagnosis was retained on the basis of epidemiological, clinical and biological data.
  
  
  CONCLUSIONS
  These simple and accessible criteria should allow better handling of patients with hemorragic disorders.
authors.affiliation: Service d'hématologie, Université Cheikh Anta Diop. awaoumar2000@yahoo.fr
authors.forename: Fall A O
authors.initials: FA
authors.lastname: Touré
authors.forename: Guèye M
authors.initials: GM
authors.lastname: Kane
authors.forename: S
authors.initials: S
authors.lastname: Diop
authors.forename: Dièye T
authors.initials: DT
authors.lastname: Ndiaye
authors.forename: H
authors.initials: H
authors.lastname: Diao
authors.forename: L
authors.initials: L
authors.lastname: Diouf
authors.forename: G
authors.initials: G
authors.lastname: Diaw
authors.forename: D
authors.initials: D
authors.lastname: Thiam
authors.forename: J C
authors.initials: JC
authors.lastname: Moreau
authors.forename: L
authors.initials: L
authors.lastname: Diakhaté
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008595:Menorrhagia / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D015995:Prevalence; D011446:Prospective Studies; D012675:Senegal / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013997:Time Factors; D014842:von Willebrand Diseases / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor