title: Prognosticators and the role of lymphadenectomy in uterine leiomyosarcomas.
abstract: OBJECTIVE
  To analyze prognostic factors, the role of lymphadenectomy and postoperative adjuvant treatments in patients with uterine leiomyosarcomas (LMS).
  
  
  METHODS
  Sixty-three patients with uterine LMS are retrospectively analyzed with respect to both DFS and OS.
  
  
  RESULTS
  Multivariate DFS analysis revealed percentage necrosis to be the unique factor to be significant (median DFS was 3.31 years for <25% necrosis and 0.78 for >25% necrosis). Multivariate analysis revealed the mitotic counts to be the unique significant factor affecting the OS (median OS was 7.20 and 1.73 years, respectively, for patients with mitotic counts of 1-5 and >6; respectively). Median DFS was 2.51 years for patients who had undergone lymphadenectomy and 2.36 years for remaining who did not have a lymphadenectomy procedure (P = 0.4). With respect to OS, median values were 2.44 and 3.16 years, respectively (P = 0.7). Number of the resected lymph nodes was also not significant for both OS and DFS.
  
  
  CONCLUSIONS
  Mitotic counts and percentage necrosis have significant effects on OS and DFS; respectively. Neither the performance nor the extent of lymphadenectomy has an effect on patient survival.
authors.affiliation: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Baskent University School of Medicine, Tandogan, Ankara, Turkey.
authors.forename: Ali
authors.initials: A
authors.lastname: Ayhan
authors.forename: Guldeniz
authors.initials: G
authors.lastname: Aksan
authors.forename: Murat
authors.initials: M
authors.lastname: Gultekin
authors.forename: Sertac
authors.initials: S
authors.lastname: Esin
authors.forename: Cigdem
authors.initials: C
authors.lastname: Himmetoglu
authors.forename: Polat
authors.initials: P
authors.lastname: Dursun
authors.forename: Alp
authors.initials: A
authors.lastname: Usubutun
authors.forename: Kunter
authors.initials: K
authors.lastname: Yuce
mesh_terms: D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007890:Leiomyosarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery; D008197:Lymph Node Excision / Q000706:statistics & numerical data*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D008940:Mitotic Index; D015999:Multivariate Analysis; D009336:Necrosis; D011379:Prognosis; D012044:Regression Analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D014594:Uterine Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery