title: Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care.
abstract: The functional loss of mitochondria represents an inherent part in modern theories trying to explain the cutaneous aging process. The present study shows significant age-dependent differences in mitochondrial function of keratinocytes isolated from skin biopsies of young and old donors. Our data let us postulate that energy metabolism shifts to a predominantly non-mitochondrial pathway and is therefore functionally anaerobic with advancing age. CoQ10 positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo.
authors.affiliation: R&D, Beiersdorf AG, Hamburg, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Prahl
authors.forename: T
authors.initials: T
authors.lastname: Kueper
authors.forename: T
authors.initials: T
authors.lastname: Biernoth
authors.forename: Y
authors.initials: Y
authors.lastname: Wöhrmann
authors.forename: A
authors.initials: A
authors.lastname: Münster
authors.forename: M
authors.initials: M
authors.lastname: Fürstenau
authors.forename: M
authors.initials: M
authors.lastname: Schmidt
authors.forename: C
authors.initials: C
authors.lastname: Schulze
authors.forename: K-P
authors.initials: KP
authors.lastname: Wittern
authors.forename: H
authors.initials: H
authors.lastname: Wenck
authors.forename: G-M
authors.initials: GM
authors.lastname: Muhr
authors.forename: T
authors.initials: T
authors.lastname: Blatt
mesh_terms: D000328:Adult; D000368:Aged; D000693:Anaerobiosis / Q000502:physiology*; D042967:Electron Transport Complex I / Q000378:metabolism; D042963:Electron Transport Complex II / Q000378:metabolism; D014450:Electron Transport Complex III / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000096:biosynthesis; D006019:Glycolysis; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism; D019344:Lactic Acid / Q000096:biosynthesis; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology*; D009840:Oligomycins / Q000494:pharmacology; D006180:Proton-Translocating ATPases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000254:growth & development* / Q000528:radiation effects / Q000648:ultrastructure; D015595:Skin Aging / Q000502:physiology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D051272:Glucose Transporter Type 1; D009840:Oligomycins; D017382:Reactive Oxygen Species; D014451:Ubiquinone; D019344:Lactic Acid; D042963:Electron Transport Complex II; D006180:Proton-Translocating ATPases; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III; C024989:coenzyme Q10; D005947:Glucose