title: Antibacterial and antifouling polymer brushes incorporating antimicrobial peptide.
abstract: Surface-initiated atom transfer radical polymerization (ATRP) has been used to prepare antifouling copolymer brushes based on 2-(2-methoxyethoxy)ethyl methacrylate (MEO(2)MA) and hydroxyl-terminated oligo(ethylene glycol) methacrylate (HOEGMA). The amount of hydroxyl reactive groups incorporated into the brushes was varied by changing the composition of the monomer mixture. These coatings were subsequently functionalized by a natural antibacterial peptide, magainin I, via an oriented chemical grafting on hydroxyl groups, which maintains the activity of the peptide. The antibacterial activity of the functionalized brushes was successfully tested against two different strains of gram-positive bacteria.
authors.affiliation: Melville Laboratory for Polymer Synthesis, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB21EW, United Kingdom. karine.glinel@univ-rouen.fr
authors.forename: Karine
authors.initials: K
authors.lastname: Glinel
authors.forename: Alain M
authors.initials: AM
authors.lastname: Jonas
authors.forename: Thierry
authors.initials: T
authors.lastname: Jouenne
authors.forename: Jérôme
authors.initials: J
authors.lastname: Leprince
authors.forename: Ludovic
authors.initials: L
authors.lastname: Galas
authors.forename: Wilhelm T S
authors.initials: WT
authors.lastname: Huck
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D020099:Coated Materials, Biocompatible / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008422:Materials Testing; D010455:Peptides / Q000008:administration & dosage; D011109:Polymethacrylic Acids / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D010455:Peptides; D011109:Polymethacrylic Acids