[The effect of ibuprofen and acetylsalicylic acid on cognitive impairment, total antioxidant power and isoprostane serum].
BACKGROUND
There are controversial studies on the prevention of Alzheimer's disease with nonsteroidal antiinflammatory drugs (NSAIDs). The objective of this study was to evaluate the effect of ibuprofen and acetylsalicylic acid on cognitive impairment, serum total antioxidant power (TAP) and isoprostane (8-iso-PGF2alpha).


METHODS
From April 2004 to February 2006, a Folstein mini-mental state (MMSE), Syndrome Kurtz Test (SKT) and a geriatric depression scale (Yasevage) were applied to eighteen, 55-56 years old eligible women. All women (n= 18) with normal cognitive state were randomized to ibuprofen 400 mg per day (n= 9) and acetylsalicylic acid 500 mg per day (n= 9) for one year. Serum TAP and 8-iso-PGF2alpha were performed at baseline, after six months and one year of treatment.


RESULTS
After one year of treatment with acetylsalicylic acid five women (55.6%) raised their score 4 points in MMSE compared with 3 points increased (33.3%) showed by the ibuprofen group. TAP increased (p=0.01) and 8-iso-PGF2alpha reduced (p=0.01) in both groups compared with baseline.


CONCLUSIONS
Both drugs improved the cognitive state andoxidative status of our population.
Ibáñez-Hernández
Marcia Gabriela
MG
Clinica de Demencias, Hospital de Especialidades, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco, México. marciagabrielaibanez@yahoo.com.mx
Macías-Islas
Miguel Angel
MA
Zavalza-Gómez
Ana Bertha
AB
Pacheco-Moisés
Fermín Paul
FP
Ortiz
Genaro Gabriel
GG
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000517:prevention & control; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D028421:Isoprostanes / Q000097:blood*; D008875:Middle Aged; D016037:Single-Blind Method
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D028421:Isoprostanes; D001241:Aspirin; D007052:Ibuprofen