SOX7, down-regulated in colorectal cancer, induces apoptosis and inhibits proliferation of colorectal cancer cells.
The sex-determining region Y-box 7 (Sox7) is a member of high mobility group (HMG) transcription factor family, essential for embryonic development and endoderm differentiation. Deregulation of Wnt signaling pathway is a hallmark of colorectal cancer. Our results showed that the expression level of SOX7 was frequently down-regulated in human colorectal cancer cell lines and in primary colorectal tumor tissues, and the SOX7 silencing was partially due to the aberrant DNA methylation of the gene. Restoration of SOX7 induced colorectal cancer cell apoptosis, inhibited cell proliferation and colony formation. In addition, SOX7 efficiently suppressed beta-catenin-mediated transcriptional activity.
Zhang
Yu
Y
The Institute of Genetics and Cytology, Northeast Normal University, Changchun, China.
Huang
Shuyan
S
Dong
Wei
W
Li
Lin
L
Feng
Yunpeng
Y
Pan
Lina
L
Han
Zhenkun
Z
Wang
Xiuli
X
Ren
Guoling
G
Su
Dongmei
D
Huang
Baiqu
B
Lu
Jun
J
D017209:Apoptosis; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D015179:Colorectal Neoplasms / Q000473:pathology / Q000517:prevention & control*; D015536:Down-Regulation; D044127:Epigenesis, Genetic; D020868:Gene Silencing; D006801:Humans; D055760:SOXF Transcription Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D051176:beta Catenin / Q000037:antagonists & inhibitors
C484456:SOX7 protein, human; D055760:SOXF Transcription Factors; D051176:beta Catenin