Prostanoids in health and disease.
The prostanoids are a family of lipid mediators generated by the action of cyclooxygenase on a 20-carbon unsaturated fatty acid, arachidonic acid. Prostanoids are generated widely in response to diverse stimuli and, acting in a paracrine or autocrine manner, play important roles in normal physiology and disease. This review summarizes the current knowledge on prostanoid generation and the roles of individual mediators, their biosynthetic pathways, and their receptors in health and disease.
Smyth
Emer M
EM
Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104, USA.
Grosser
Tilo
T
Wang
Miao
M
Yu
Ying
Y
FitzGerald
Garret A
GA
D000818:Animals; D004194:Disease; D006262:Health; D006801:Humans; D011453:Prostaglandins / Q000737:chemistry / Q000378:metabolism*; D011982:Receptors, Prostaglandin / Q000378:metabolism
D011453:Prostaglandins; D011982:Receptors, Prostaglandin