title: POLAR MAPPER: a computational tool for integrated visualization of protein interaction networks and mRNA expression data.
abstract: Polar Mapper is a computational application for exposing the architecture of protein interaction networks. It facilitates the system-level analysis of mRNA expression data in the context of the underlying protein interaction network. Preliminary analysis of a human protein interaction network and comparison of the yeast oxidative stress and heat shock gene expression responses are addressed as case studies.
authors.affiliation: Unidade de Sistemas Biológicos, Biocant, Cantanhede, Portugal.
authors.forename: Joana P
authors.initials: JP
authors.lastname: Gonçalves
authors.forename: Mário
authors.initials: M
authors.lastname: Grãos
authors.forename: André X C N
authors.initials: AX
authors.lastname: Valente
mesh_terms: D003198:Computer Simulation; D008954:Models, Biological; D025941:Protein Interaction Mapping / Q000379:methods*; D020543:Proteome / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D012984:Software; D018511:Systems Integration; D014584:User-Computer Interface
chemical_list: D020543:Proteome; D012333:RNA, Messenger