Dolichandroside A, a new alpha-glucosidase inhibitor and DPPH free-radical scavenger from Dolichandrone falcata seem.
A new phenylpropanoid glycoside, dolichandroside-A, together with seven known compounds alpha-lapachone, lapachol, aloesaponarin II, 8-hydroxydehydroiso-alpha-lapachone, beta-sitosterol, 3,8-dihydroxydehydroiso-alpha-lapachone and verbascoside were isolated from the active ethyl acetate soluble extract of heartwood of Dolichandrone falcata. All except for dolichandroside-A are known compounds, but have been isolated for the first time from this plant. The structure of all these compounds was determined on the basis of 1D- and 2D-NMR spectral data. All the isolates were tested for alpha-glucosidase inhibitory and DPPH radical scavenging activity. This is the first report identifying DPPH scavenging activity and alpha-glucosidase inhibitory activity in D. falcata. Furthermore, along with a new compound, dolichandroside-A, this study also assigns for the first time alpha-glucosidase inhibitory activity to verbascoside and aloe saponarin-II.
Aparna
P
P
Natural Products Laboratory, Organic Chemistry-I Division, Indian Institute of Chemical Technology, Hyderabad-500 007, India.
Tiwari
Ashok K
AK
Srinivas
Pullela V
PV
Ali
A Zehra
AZ
Anuradha
V
V
Rao
J Madhusudana
JM
D000880:Anthraquinones / Q000494:pharmacology; D029402:Bignoniaceae / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010636:Phenols / Q000494:pharmacology; D010851:Picrates / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols
D000880:Anthraquinones; D001713:Biphenyl Compounds; D004791:Enzyme Inhibitors; D016166:Free Radical Scavengers; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D006027:Glycosides; D010636:Phenols; D010851:Picrates; D010936:Plant Extracts; C539816:dolichandroside A; C058956:acteoside; D059808:Polyphenols; C092187:aloesaponarin II; C004931:1,1-diphenyl-2-picrylhydrazyl