title: Characterisation of the "vulnerable" coronary plaque by multi-detector computed tomography: a correlative study with intravascular ultrasound-derived radiofrequency analysis of plaque composition.
abstract: OBJECTIVE
  To assess plaque characteristics by multi-detector computed tomography angiography in patients with known coronary artery disease and to compare these findings with those obtained with intravascular ultrasound-derived radiofrequency analysis of plaque composition.
  
  
  RESULTS
  By computed tomography, lesions were classified on the basis of Hounsfield Units as non-calcified, calcified, or mixed. By intravascular ultrasound-derived radiofrequency analysis, plaques were classified according to the relative composition of components with specific backscatter characteristics (necrotic core, fibrous, fibro-fatty, calcium). Thin cap fibroatheroma (defined as necrotic core component >10% without evidence of fibrotic cap, calcium >5%, remodelling index >1.05) was considered as vulnerable plaque. Seventy-eight plaques were analysed. By computed tomography, 22 plaques were classified as non-calcified and 56 as mixed. A higher incidence of mixed plaques was observed among lesions causing unstable angina and non-ST elevation myocardial infarction compared to stable angina (76% vs 38%, p=0.04). Plaque composition by radiofrequency analysis was significantly different between mixed and non-calcified plaques by computed tomography. The calcium content was 6.0+/-3.2% vs 2.5+/-1.8% (p=0.001), necrotic core was 14.0+/-6.9% vs 7.5+/-5.6% (p=0.03) and fibrous tissue was 59.0+/-7.5% vs 67.0+/-5.9% (p=0.03), for mixed vs non-calcified plaques, respectively. Positive, negative predictive value and diagnostic accuracy for detection of vulnerable plaque by computed tomography was 77, 54 and 59%.
  
  
  CONCLUSIONS
  Mixed plaque by computed tomography correlates with plaque composition as determined by intravascular ultrasound-derived radiofrequency analysis. However, the present diagnostic accuracy of computed tomography is not high enough to support its use for non invasive detection of vulnerable coronary plaque.
authors.affiliation: Cardiovascular Center, Aalst, Belgium.
authors.forename: Giovanna
authors.initials: G
authors.lastname: Sarno
authors.forename: Piet
authors.initials: P
authors.lastname: Vanhoenacker
authors.forename: Isabel
authors.initials: I
authors.lastname: Decramer
authors.forename: Joanne D
authors.initials: JD
authors.lastname: Schuijf
authors.forename: Johanna
authors.initials: J
authors.lastname: Schuijf
authors.forename: Gabjia
authors.initials: G
authors.lastname: Pundziute
authors.forename: Pundziute
authors.initials: P
authors.lastname: Gabjia
authors.forename: Paulina
authors.initials: P
authors.lastname: Margolis
authors.forename: Satya
authors.initials: S
authors.lastname: Gupta
authors.forename: Jeroen J
authors.initials: JJ
authors.lastname: Bax
authors.forename: Jeroen
authors.initials: J
authors.lastname: Bax
authors.forename: William
authors.initials: W
authors.lastname: Wijns
mesh_terms: D000368:Aged; D000789:Angina, Unstable / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000000981:diagnostic imaging; D017023:Coronary Angiography / Q000592:standards*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards*; D018084:Ultrasonography, Interventional / Q000592:standards*