[Hypotensive effect of oxatriazolium-5-olate derivative].
Intravenous administration of azasidnon-6 (oxatriazolium-5-olate derivative) induces prolonged dose-dependent decrease in arterial blood pressure in awake Wistar and SHR rats. Hypotensive effects of azasidnon-6 in SHR rats is significantly higher during inhibition of endogenous NO synthesis.
Artem'eva
M M
MM
Postnikov
A B
AB
Akinfrieva
O V
OV
Daliger
I L
IL
Shevelev
S A
SA
Medvedev
O S
OS
Medvedeva
N A
NA
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003692:Delayed-Action Preparations / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D014230:Triazoles / Q000494:pharmacology*
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D014230:Triazoles; D009569:Nitric Oxide