title: Prevalence and time course of acute mountain sickness in older children and adolescents after rapid ascent to 3450 meters.
abstract: OBJECTIVE
  Acute mountain sickness is a frequent and debilitating complication of high-altitude exposure, but there is little information on the prevalence and time course of acute mountain sickness in children and adolescents after rapid ascent by mechanical transportation to 3500 m, an altitude at which major tourist destinations are located throughout the world.
  
  
  METHODS
  We performed serial assessments of acute mountain sickness (Lake Louise scores) in 48 healthy nonacclimatized children and adolescents (mean +/- SD age: 13.7 +/- 0.3 years; 20 girls and 28 boys), with no previous high-altitude experience, 6, 18, and 42 hours after arrival at the Jungfraujoch high-altitude research station (3450 m), which was reached through a 2.5-hour train ascent.
  
  
  RESULTS
  We found that the overall prevalence of acute mountain sickness during the first 3 days at high altitude was 37.5%. Rates were similar for the 2 genders and decreased progressively during the stay (25% at 6 hours, 21% at 18 hours, and 8% at 42 hours). None of the subjects needed to be evacuated to lower altitude. Five subjects needed symptomatic treatment and responded well.
  
  
  CONCLUSIONS
  After rapid ascent to high altitude, the prevalence of acute mountain sickness in children and adolescents was relatively low; the clinical manifestations were benign and resolved rapidly. These findings suggest that, for the majority of healthy nonacclimatized children and adolescents, travel to 3500 m is safe and pharmacologic prophylaxis for acute mountain sickness is not needed.
authors.affiliation: Botnar Center for Extreme Medicine, Department of Internal Medicine, University Hospital, Lausanne, Switzerland.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bloch
authors.forename: Hervé
authors.initials: H
authors.lastname: Duplain
authors.forename: Stefano F
authors.initials: SF
authors.lastname: Rimoldi
authors.forename: Thomas
authors.initials: T
authors.lastname: Stuber
authors.forename: Susi
authors.initials: S
authors.lastname: Kriemler
authors.forename: Yves
authors.initials: Y
authors.lastname: Allemann
authors.forename: Claudio
authors.initials: C
authors.lastname: Sartori
authors.forename: Urs
authors.initials: U
authors.lastname: Scherrer
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000367:Age Factors; D000531:Altitude; D000532:Altitude Sickness / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009051:Mountaineering / Q000502:physiology; D015995:Prevalence; D013997:Time Factors