title: Enantioselective organocatalytic michael addition of malonates to alpha,beta-unsaturated ketones.
abstract: A novel type of primary amine thiourea organocatalysts derived from 1,2-diaminocyclohexane and 9-amino (9-deoxy) cinchona alkaloid was developed into asymmetric Michael addition of malonates to enones. A series of cyclic and acyclic enones could react very well with different malonates in the presence of 4 with 0.5-10 mol % catalyst loading affording chiral Michael adducts with excellent yields and ee values.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Science, 457 Zhongshan Road, Dalian 116023, P. R. China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Li
authors.forename: Shigang
authors.initials: S
authors.lastname: Wen
authors.forename: Feng
authors.initials: F
authors.lastname: Yu
authors.forename: Qiaoxia
authors.initials: Q
authors.lastname: Liu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Li
authors.forename: Yongcan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
authors.forename: Jinxing
authors.initials: J
authors.lastname: Ye
mesh_terms: D002930:Cinchona Alkaloids / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D008314:Malonates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D007659:Ketones; D008314:Malonates