title: [The role of chemokines CCL3/ MIP-1 alfa and CCL4/ MIP-1 beta in pathogenesis of dry eye syndrome].
abstract: OBJECTIVE
  To evaluate the concentration of chemokines CCL3/ MIP-1 alfa and CCL4/ MIP-1 beta in film tears in patients with dry eye syndrome.
  
  
  METHODS
  Tears samples were collected from 62 patients with dry eye syndrome and 18 patients from control group. The concentration of chemokines in film tears were determined by immunoenzymatic assay ELISA.
  
  
  RESULTS
  We found statistically increased levels of chemokines CCL3/ MIP-1 alfa and CCL4/ MIP-1 beta in film tears of patients with dry eye syndrom compared with control group.
  
  
  CONCLUSIONS
  Inflammation may play role in pathogenesis of dry eye syndrome.
authors.affiliation: Z Oddziału Chorób Oczu Wojewódzkiego Szpitala Zespolonego, Białymstoku.
authors.forename: Roman
authors.initials: R
authors.lastname: Malesiński
authors.forename: Alina
authors.initials: A
authors.lastname: Bakunowicz-Łazarczyk
authors.forename: Jolanta
authors.initials: J
authors.lastname: Wysocka
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D054405:Chemokine CCL3 / Q000032:analysis*; D054407:Chemokine CCL4 / Q000032:analysis*; D015352:Dry Eye Syndromes / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000276:immunology*
chemical_list: D054405:Chemokine CCL3; D054407:Chemokine CCL4; D007155:Immunologic Factors