Search for antimycobacterial constituents from a Tibetan medicinal plant, Gentianopsis paludosa.
From the whole plant of Gentianopsis paludosa seven compounds were isolated and identified to be 1,7-dihydroxy-3,8-dimethoxyxanthone (1), 1,7,8-trihydroxy-3-methoxyxanthone (2), 1-hydroxy-3,7,8-trimethoxyxanthone (3), 1,8-dihydroxy-2,6-dimethoxyxanthone (4), oleanolic acid (5), 4',5,7-trihydroxyflavone (6) and luteolin-7-O-glucoside (7). Compounds 1, 2, 3 and 5 showed modest inhibitory effect against the growth of Mycobacterium smegmatis and M. tuberculosis.
Yeung
Ming-Fai
MF
School of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong.
Lau
Clara B S
CB
Chan
Raphael C Y
RC
Zong
Yuying
Y
Che
Chun-Tao
CT
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D029965:Gentianaceae / Q000737:chemistry*; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D018609:Tibet; D044004:Xanthones / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D044004:Xanthones