Periconceptional undernutrition of ewes impairs glucose tolerance in their adult offspring.
Maternal undernutrition throughout pregnancy can have long-term effects on the health of adult offspring. Undernutrition around the time of conception alters growth, metabolism, and endocrinology of the sheep fetus, but the impact on offspring after birth is largely unknown. We determined the effect of maternal periconceptional undernutrition in sheep on glucose tolerance in the offspring before and after puberty. Undernourished (UN) ewes were fed individually to maintain weight loss of 10-15% bodyweight from 61 d before until 30 d after mating. Offspring (24 UN, 30 control) underwent an i.v. glucose tolerance test at 4 and 10 mo of age. Glucose tolerance was similar in both groups at 4 mo. Insulin area under the curve increased by 33% between 4 and 10 mo (101 +/- 8 versus 154 +/- 12 ng x min x mL(-1), p < 0.0001). At 10 mo, UN offspring had a 10% greater glucose area under the curve than controls (809 +/- 22 versus 712 +/- 20 mM x min, p < 0.01), a reduced first phase insulin response (p = 0.003) which was particularly apparent in females and in singletons, and a decreased insulin:glucose ratio (p = 0.01). We conclude that maternal undernutrition around the time of conception results in impaired glucose tolerance in postpubertal offspring.
Todd
Sarah E
SE
Liggins Institute, University of Auckland, Private Bag 92019, Auckland 1023, New Zealand.
Oliver
Mark H
MH
Jaquiery
Anne L
AL
Bloomfield
Frank H
FH
Harding
Jane E
JE
D000367:Age Factors; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D005260:Female; D005306:Fertilization; D005508:Food Deprivation; D018149:Glucose Intolerance / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008297:Male; D044342:Malnutrition / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D039401:Prenatal Nutritional Physiological Phenomena; D012741:Sexual Maturation; D012756:Sheep; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin