title: [Dobutamine stress echocardiography in patients with hypertrophic cardiomyopathy].
abstract: OBJECTIVE
  To evaluate the safety and efficiency of the dobutamine stress echocardiography in patients with hypertrophic cardiomyopathy and estimate the difference between provokable obstruction and resting obstruction in these patients.
  
  
  METHODS
  Echocardiography was performed in 22 patients with HCM (LVOTPG < 50 mm Hg at rest, 1 mm Hg = 0.133 kPa) at rest and at the end point of dobutamine stress. Dobutamine was administered via an infusion pump, starting at a dose of 5 microg x min(-1) x kg(-1) and increasing every 5 minutes by 5 microg x min(-1) x kg(-1) till the maximum dose of 20 microg x min(-1) x kg(-1). Fifty-seven patients with HCM (LVOTPG > 50 mm Hg at rest) were also studied at rest.
  
  
  RESULTS
  In these 22 patients, the mean maximum velocity of LVOT was 5.39 +/- 1.60 m/s, the mean maximum LVOTPG was 125.7 +/- 62.4 mm Hg at the end point of dobutamine stress and the mean dose of dobutamine was 13.90 +/- 6.85 microg x min(-1)xkg(-1). Sixteen patients evidenced positive stress results at the end point of dobutamine stress. The main difference between the provokable obstruction and resting obstruction was that in provokable obstruction patients, the SAM positive patients were fewer and the proportion of Maron II patients was higher (50%).
  
  
  CONCLUSIONS
  Dobutamine stress echocardiography was a safe and sensitive way for detecting patients with hypertrophic cardiomyopathy. Provokable obstruction patients had fewer SAM and higher proportion of Maron II.
authors.affiliation: Coronary Heart Disease Center, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.
authors.forename: Jian-song
authors.initials: JS
authors.lastname: Yuan
authors.forename: Shu-bin
authors.initials: SB
authors.lastname: Qiao
authors.forename: Shi-jie
authors.initials: SJ
authors.lastname: You
authors.forename: Wei-xian
authors.initials: WX
authors.lastname: Yang
authors.forename: Xiu-zhang
authors.initials: XZ
authors.lastname: Lü
authors.forename: Feng-huan
authors.initials: FH
authors.lastname: Hu
authors.forename: Run-lin
authors.initials: RL
authors.lastname: Gao
authors.forename: Ji-lin
authors.initials: JL
authors.lastname: Chen
authors.forename: Yue-jin
authors.initials: YJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D004280:Dobutamine / Q000008:administration & dosage; D025401:Echocardiography, Stress / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004280:Dobutamine