title: Association of KIR genotypes and haplotypes with susceptibility to chronic hepatitis B virus infection in Chinese Han population.
abstract: Killer immunoglobulin-like receptor (KIR) genes can regulate the activation of NK and T cells upon interaction with HLA class I molecules. Hepatitis B virus (HBV) infection has been regarded as a multi-factorial disorder disease. Previous studies revealed that KIRs were involved in HCV and HIV infection or clearance. The aim of this study was to explore the possibility of the inheritance of KIR genotypes and haplotypes as a candidate for susceptibility to persistent HBV infection or HBV clearance. The sequence specific primer polymerase chain reaction (SSP-PCR) was employed to identify the KIR genes and pseudogenes in 150 chronic hepatitis B (CHB) patients, 251 spontaneously recovered (SR) controls, and 412 healthy controls. The frequencies of genotype G, M, FZ1 increased in CHB patients compared with healthy control subjects. The frequency of genotype AH was higher in SR controls than that in both CHB patients and healthy controls. The carriage frequencies of genotype G and AH were higher; while, the frequencies of AF and AJ were lower in SR controls than those in healthy control subjects. The frequency of A haplotype was lower, whereas, the frequency of B haplotype was higher in CHB patients and SR controls than those in healthy controls. In healthy controls, haplotype 4 was found lower compared with that in CHB patients and SR controls and the frequency of haplotype 5 was higher in SR controls than that in other two groups. Based on these findings, it seems that the genotypes M and FZ1 are HBV susceptive genotypes; AH, on the other hand, may be protective genotypes that facilitate the clearance of HBV. It appears that the haplotype 4 is HBV susceptive haplotype, whereas, haplotype 5 may be the protective haplotype that facilitates the clearance of HBV.
authors.affiliation: Department of Laboratory Medicine, Shandong Provincial Hospital, Shandong University, Jinan, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Lu
authors.forename: Bingchang
authors.initials: B
authors.lastname: Zhang
authors.forename: Shijun
authors.initials: S
authors.lastname: Chen
authors.forename: Zhongtao
authors.initials: Z
authors.lastname: Gai
authors.forename: Zhaolei
authors.initials: Z
authors.lastname: Feng
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Liu
authors.forename: Yiqing
authors.initials: Y
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Wen
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Yulian
authors.initials: Y
authors.lastname: Jiao
authors.forename: Chunyan
authors.initials: C
authors.lastname: Ma
authors.forename: Song
authors.initials: S
authors.lastname: Shao
authors.forename: Xiangfa
authors.initials: X
authors.lastname: Cui
authors.forename: Guojian
authors.initials: G
authors.lastname: Chen
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Li
authors.forename: Yueran
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000235:genetics*; D006801:Humans; D054340:Receptors, KIR / Q000235:genetics*
chemical_list: D054340:Receptors, KIR