title: Application of quartz crystal nanobalance for simultaneous determination of vanillylmandelic and homovanillic acids by a net analyte signal-based method.
abstract: Homovanillic acid (HVA) and vanillylmandelic acid (VMA) were selectively determined by quartz crystal nanobalance sensor in conjunction with net analyte signal (NAS)-based method called HLA/GO. An orthogonal design was applied for the formation of calibration and prediction sets including HVA, VMA, and some common and structurally similar urine compounds. The selection of the optimal time range involved the calculation of the NAS regression plot in any considered time window for each test sample. The searching of a region with maximum linearity of NAS regression plot (minimum error indicator) and minimum of predicted error sum of squares value was carried out by applying a moving window strategy. Based on the obtained results, the differences on the adsorption profiles in the time range between 1 and 300 s were used to determine mixtures of compounds by HLA/GO method. Several figures of merit like selectivity, sensitivity, analytical sensitivity, and limit of detection were calculated for both compounds. The results showed that the method was successfully applied for the determination of VMA and HVA.
authors.affiliation: Department of Natural Sciences, Faculty of Animal Sciences, University of Tabriz, Tabriz, Iran. mshojaei@tabrizu.ac.ir
authors.forename: Maryam
authors.initials: M
authors.lastname: Shojaei
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Mirmohseni
authors.forename: Yadollah
authors.initials: Y
authors.lastname: Omidi
authors.forename: Maryam
authors.initials: M
authors.lastname: Farbodi
mesh_terms: D000465:Algorithms; D045424:Complex Mixtures / Q000032:analysis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006719:Homovanillic Acid / Q000032:analysis*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014642:Vanilmandelic Acid / Q000032:analysis*
chemical_list: D045424:Complex Mixtures; D014642:Vanilmandelic Acid; D006719:Homovanillic Acid