title: Coffee drinking and endometrial cancer risk: a metaanalysis of observational studies.
abstract: We conducted a metaanalysis of published studies on the relation between coffee drinking and endometrial cancer risk, which included 2 cohort (201 cases) and 7 case-control studies (2409 cases). The summary relative risk (RR) for coffee drinkers vs nondrinkers was 0.80 (95% confidence interval [CI], 0.68-0.94), with significant heterogeneity between studies. Compared with nondrinkers, the summary RR was 0.87 (95% CI, 0.78-0.97) for low-to-moderate coffee drinkers and 0.64 (95% CI, 0.48-0.86) for heavy coffee drinkers. The summary RR for an increase of 1 cup/d was 0.93 (95% CI, 0.89-0.97), which suggests an inverse relation between coffee and endometrial cancer. However, the causality must be confirmed.
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. bravi@marionegri.it
authors.forename: Francesca
authors.initials: F
authors.lastname: Bravi
authors.forename: Lorenza
authors.initials: L
authors.lastname: Scotti
authors.forename: Cristina
authors.initials: C
authors.lastname: Bosetti
authors.forename: Silvano
authors.initials: S
authors.lastname: Gallus
authors.forename: Eva
authors.initials: E
authors.lastname: Negri
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tavani
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage; D001628:Beverages; D003069:Coffee; D004326:Drinking; D004327:Drinking Behavior; D016889:Endometrial Neoplasms / Q000209:etiology*; D005260:Female; D006801:Humans; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D003069:Coffee