Elite suppression of HIV-1 replication.
Rare HIV-1-infected individuals are able to control viral replication without antiretroviral therapy. In this issue of Immunity, Migueles et al. (2008) show that HIV-1-specific CD8+ T cells from these individuals effectively suppress viral replication by granzyme B-mediated killing of target cells.
Blankson
Joel N
JN
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Siliciano
Robert F
RF
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D053804:Granzymes / Q000276:immunology* / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology* / Q000502:physiology; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D006801:Humans; D011110:Polymorphism, Genetic; D014779:Virus Replication / Q000276:immunology*
D015395:Histocompatibility Antigens Class I; D053804:Granzymes