title: Matched molecular pair analysis of activity and properties of glycogen phosphorylase inhibitors.
abstract: Matched molecular pair analysis has been used in design of inhibitors of glycogen phosphorylase.
authors.affiliation: AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, UK.
authors.forename: Alan M
authors.initials: AM
authors.lastname: Birch
authors.forename: Peter W
authors.initials: PW
authors.lastname: Kenny
authors.forename: Iain
authors.initials: I
authors.lastname: Simpson
authors.forename: Paul R O
authors.initials: PR
authors.lastname: Whittamore
mesh_terms: D002244:Carbon / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors* / Q000737:chemistry; D020128:Inhibitory Concentration 50; D008745:Methylation; D008956:Models, Chemical; D015999:Multivariate Analysis; D009584:Nitrogen / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D012995:Solubility; D013777:Tetrazoles / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D002264:Carboxylic Acids; D004791:Enzyme Inhibitors; D013777:Tetrazoles; D014867:Water; D002244:Carbon; D024981:Glycogen Phosphorylase; D009584:Nitrogen