Non-convulsive status epilepticus following antibiotic therapy as a cause of unexplained loss of consciousness in patients with renal failure.
BACKGROUND
Non-convulsive status epilepticus (NCSE): a condition that may be associated with different levels of altered consciousness without any apparent motor signs. There are published reports that it may be associated with antibiotic use patients with renal failure.


METHODS
This is a retrospective analysis of our 12 NCSE (2 men, 10 women, a mean age: 58.4 +/- 17.5 range of 29-85 years) patients with renal failure who have used antibiotics.


RESULTS
Twelve patients were receiving a total of 19 antibiotics including mainly beta-lactams. The mean duration of time between start of antibiotic treatment and NCSE was 8.0 (3-21) days. In all of the patients, neurological symptoms were slowly progressive and consisted of depression of consciousness and/or disorientation. Diazepam administration resulted in marked reduction or completely disappears of epileptic activity. Four of 12 patients (33%) died, but none of were associated with NCSE but primarily associated with infection developed secondary to the preexisting disease and with congestive heart failure which patients already had.


CONCLUSIONS
Antibiotics, especially beta-lactams could be neurotoxic and may cause of NCSE. NCSE should be considered in patients with unexplained loss of consciousness; EEG must be a part of investigations in patients with uraemia receiving antibiotics.
Ozturk
Savas
S
Division of Nephrology, Department of Internal Medicine, Haseki Training and Research Hospital, Istanbul, Turkey. savasozturkdr@yahoo.com.|Haseki Egitim ve Arsatirma Hastanesi, Ic Hastaliklari, 5. dahiliye servisi, Haseki, Fatih, Istanbul, Turkey. savasozturkdr@yahoo.com.
Kocabay
Gonenc
G
Istanbul Faculty of Medicine, Department of Internal Medicine, Istanbul University, Istanbul, Turkey.
Topcular
Baris
B
Istanbul Faculty of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey.
Yazici
Halil
H
Istanbul Faculty of Medicine, Division of Nephrology, Department of Internal Medicine, Istanbul University, Istanbul, Turkey.
Cagatay
Arif Atahan
AA
Istanbul Faculty of Medicine, Department of Clinical Bacteriology and Infectious Disease, Istanbul University, Istanbul, Turkey.
Bahat
Gulistan
G
Istanbul Faculty of Medicine, Division of Geriatrics, Department of Internal Medicine, Istanbul University, Istanbul, Turkey.
Baykan
Betul
B
Istanbul Faculty of Medicine, Department of Neurology, Istanbul University, Istanbul, Turkey.
Turkmen
Aydin
A
Istanbul Faculty of Medicine, Division of Nephrology, Department of Internal Medicine, Istanbul University, Istanbul, Turkey.
Yildiz
Alaattin
A
Istanbul Faculty of Medicine, Division of Nephrology, Department of Internal Medicine, Istanbul University, Istanbul, Turkey.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications* / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D013226:Status Epilepticus / Q000139:chemically induced* / Q000150:complications* / Q000453:epidemiology; D014474:Unconsciousness / Q000453:epidemiology / Q000209:etiology*; D014511:Uremia / Q000150:complications / Q000453:epidemiology
D000900:Anti-Bacterial Agents