title: [Community-acquired methicillin-resistant Staphylococcus aureus].
abstract: Recently, methicillin-resistant Staphylococcus aureus (MRSA) has emerged as a cause of community-acquired (CA) infections among patients without established risk factors for MRSA. CA-MRSA strains mainly cause mild skin and soft tissue infections in otherwise healthy children and young adults, but can also cause severe necrotizing fasciitis and pneumonia. In contrast to nosocomial MRSA, CA-MRSA are, in general, susceptible to multiple antimicrobials and present a different genotype. Most CA-MRSA strains share the staphylococcal chromosomal cassette (SCCmec) type IV and produce Panton-Valentine leukocidin (PVL), a cytotoxin that causes leukocyte destruction and tissue necrosis. At present, the predominant clone is the USA300 clone, which is widely disseminated in the United States, Europe and Australia. In Spain, the predominant clone is related to the USA300 clone. The main mechanism of transmission is close person-to-person contact, although household pets and farm animals have also been implicated. In patients with purulent skin and soft tissue infections, the mainstay of treatment is incision and drainage. Antimicrobials are indicated in patients not responding to appropriate drainage. Clindamycin, trimethoprimsulfamethoxazole or tetracyclines can be administered, while the use of fluoroquinolones should be avoided due to the rapid emergence of resistance. For severe infections, vancomycin should be used. Other alternatives are linezolid or daptomycin (only if there is no pulmonary involvement). Adequate hygiene practices are the most efficient measure to prevent spread.
authors.affiliation: Servicio de Microbiología, Hospital General Universitario Gregorio Marañón, Madrid, España. ecercenado@terra.es
authors.forename: Emilia
authors.initials: E
authors.lastname: Cercenado
authors.forename: Enrique
authors.initials: E
authors.lastname: Ruiz de Gopegui
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000235:genetics; D002648:Child; D003131:Combined Modality Therapy; D017714:Community-Acquired Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control / Q000628:therapy; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D003646:Debridement; D004322:Drainage; D005060:Europe / Q000453:epidemiology; D005098:Exotoxins / Q000235:genetics; D044404:Genomic Islands; D006801:Humans; D007956:Leukocidins / Q000235:genetics; D016106:Methicillin Resistance / Q000235:genetics; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D046915:Penicillin-Binding Proteins; D013045:Species Specificity; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control / Q000628:therapy; D014481:United States / Q000453:epidemiology; D014640:Vancomycin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D046915:Penicillin-Binding Proteins; C487789:mecA protein, Staphylococcus aureus; D014640:Vancomycin