title: Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery.
abstract: OBJECTIVE
  This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery.
  
  
  METHODS
  A prospective, randomized, double-blind, placebo-controlled study.
  
  
  METHODS
  The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University.
  
  
  METHODS
  One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups.
  
  
  METHODS
  Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline.
  
  
  RESULTS
  Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units).
  
  
  CONCLUSIONS
  Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products.
authors.affiliation: Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran. r-jalaeian@mums.ac.ir
authors.forename: Reza Jalaeian
authors.initials: RJ
authors.lastname: Taghaddomi
authors.forename: Asadollah
authors.initials: A
authors.lastname: Mirzaee
authors.forename: Alireza Sharifian
authors.initials: AS
authors.lastname: Attar
authors.forename: Abbas
authors.initials: A
authors.lastname: Shirdel
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D011446:Prospective Studies; D014148:Tranexamic Acid / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014148:Tranexamic Acid