title: Targeting STAT1 by myricetin and delphinidin provides efficient protection of the heart from ischemia/reperfusion-induced injury.
abstract: Flavonoids exhibit a variety of beneficial effects in cardiovascular diseases. Although their therapeutic properties have been attributed mainly to their antioxidant action, they have additional protective mechanisms such as inhibition of signal transducer and activator of transcription 1 (STAT1) activation. Here, we have investigated the cardioprotective mechanisms of strong antioxidant flavonoids such as quercetin, myricetin and delphinidin. Although all of them protect the heart from ischemia/reperfusion-injury, myricetin and delphinidin exert a more pronounced protective action than quercetin by their capacity to inhibit STAT1 activation. Biochemical and computer modeling analysis indicated the direct interaction between STAT1 and flavonoids with anti-STAT1 activity.
authors.affiliation: Center for Heart and Vessel Preclinical Studies, St. John Hospital and Medical Center, Wayne State University School of Medicine, Detroit, USA.
authors.forename: Tiziano M
authors.initials: TM
authors.lastname: Scarabelli
authors.forename: Sofia
authors.initials: S
authors.lastname: Mariotto
authors.forename: Safwat
authors.initials: S
authors.lastname: Abdel-Azeim
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shoji
authors.forename: Elena
authors.initials: E
authors.lastname: Darra
authors.forename: Anastasis
authors.initials: A
authors.lastname: Stephanou
authors.forename: Carol
authors.initials: C
authors.lastname: Chen-Scarabelli
authors.forename: Jean Didier
authors.initials: JD
authors.lastname: Marechal
authors.forename: Richard
authors.initials: R
authors.lastname: Knight
authors.forename: Anna
authors.initials: A
authors.lastname: Ciampa
authors.forename: Louis
authors.initials: L
authors.lastname: Saravolatz
authors.forename: Alessandra Carcereri
authors.initials: AC
authors.lastname: de Prati
authors.forename: Zhaokan
authors.initials: Z
authors.lastname: Yuan
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Cavalieri
authors.forename: Marta
authors.initials: M
authors.lastname: Menegazzi
authors.forename: David
authors.initials: D
authors.lastname: Latchman
authors.forename: Cosimo
authors.initials: C
authors.lastname: Pizza
authors.forename: David
authors.initials: D
authors.lastname: Perahia
authors.forename: Hisanori
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008958:Models, Molecular; D015394:Molecular Structure; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D050794:STAT1 Transcription Factor / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000872:Anthocyanins; D000975:Antioxidants; D005419:Flavonoids; D050794:STAT1 Transcription Factor; C040015:myricetin; C017185:delphinidin