Contrasting roles for Valpha14+ natural killer T cells in a viral model for multiple sclerosis.
Most natural killer (NK) T cells express an invariant Valpha14 T-cell receptor. To explore the contribution of NKT cells in an animal model for multiple sclerosis, Theiler's murine encephalomyelitis virus (TMEV) infection, TMEV-infected mice were treated with Valpha14 antibody. Treatment during the early stage of infection delayed the onset of demyelinating disease with higher interleukin-4 production, whereas administration during the late stage or weekly resulted in more severe demyelination with enhanced virus persistence. The effect of in vivo depletion of NKT cells differed depending on the stage of infection, suggesting contrasting roles for NKT cells over the disease course.
Tsunoda
Ikuo
I
Department of Pathology, Division of Cell Biology and Immunology, University of Utah School of Medicine, 30 North 1900 East, Salt Lake City, UT 84132, USA. ikuo.tsunoda@hsc.utah.edu
Tanaka
Tomoko
T
Taniguchi
Masaru
M
Fujinami
Robert S
RS
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D018188:Cardiovirus Infections / Q000150:complications* / Q000276:immunology / Q000628:therapy; D004195:Disease Models, Animal; D047589:Leukocyte Reduction Procedures; D051379:Mice; D008815:Mice, Inbred Strains; D009103:Multiple Sclerosis / Q000276:immunology* / Q000628:therapy / Q000821:virology*; D055611:Natural Killer T-Cells / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000037:antagonists & inhibitors / Q000276:immunology*; D017945:Theilovirus; D013997:Time Factors
D000906:Antibodies; D016693:Receptors, Antigen, T-Cell, alpha-beta