Tranexamic acid reduces blood loss in off-pump coronary artery bypass surgery.
OBJECTIVE
This study was designed to evaluate the hemostatic effect of tranexamic acid in off-pump coronary artery bypass surgery.


METHODS
A prospective, randomized, double-blind, placebo-controlled study.


METHODS
The Department of Anesthesiology and Cardiac Surgery, Medical Sciences University.


METHODS
One hundred eight patients undergoing off-pump coronary artery bypass surgery were enrolled into the study. Eight patients were withdrawn, and 100 patients were divided into 2 groups.


METHODS
Fifty patients received tranexamic acid (bolus 1 g before skin incision and followed by maintenance dose of 400 mg/h during surgery), and 50 patients received saline.


RESULTS
Hematologic parameters, volume of blood loss, blood transfusion, and other clinical data were recorded throughout the perioperative period. Twenty-four-hour postoperative blood loss was significantly less in the tranexamic acid group compared with the control group (471 +/- 182 v 844 +/- 303). Patients in the tranexamic acid group received significantly less allogeneic blood (8 v 31 units).


CONCLUSIONS
Bleeding and hemorrhagic complications and the consequent need for allogeneic transfusion are still major problems after off-pump coronary artery bypass surgery. Tranexamic acid appears to be effective in reducing postoperative bleeding and the need for allogeneic blood products.
Taghaddomi
Reza Jalaeian
RJ
Department of Anesthesiology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashad, Iran. r-jalaeian@mums.ac.ir
Mirzaee
Asadollah
A
Attar
Alireza Sharifian
AS
Shirdel
Abbas
A
D000328:Adult; D000368:Aged; D001810:Blood Volume / Q000187:drug effects / Q000502:physiology; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D011446:Prospective Studies; D014148:Tranexamic Acid / Q000494:pharmacology / Q000627:therapeutic use*
D014148:Tranexamic Acid