title: Thiazole Orange derivatives: synthesis, fluorescence properties, and labeling cancer cells.
abstract: A series of Thiazole Orange (TO) derivatives were synthesized and modified by introducing different substitutional groups on benzothiazole and 4-methylquinoline All the TO derivatives were confirmed by (1)HNMR and MS. TO derivative bearing NH(2)- was modified by folic acid and used to label breast cancer cells. The phenomenon of fluorescence enhancement was shown by the fluorescence spectrums of TO derivatives and micrographs of the labeled breast cancer cells. It offered a new try in the aspect of labeling cells by the embedded dyes.
authors.affiliation: Department of Material Science and Engineering, Tianjin Institute of Urban Construction, Tianjin 300384, China. xueningfei@126.com
authors.forename: Xuening
authors.initials: X
authors.lastname: Fei
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Gu
authors.forename: Ying
authors.initials: Y
authors.lastname: Ban
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Liu
authors.forename: Baolian
authors.initials: B
authors.lastname: Zhang
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D022082:Cellular Structures; D005260:Female; D005453:Fluorescence; D005456:Fluorescent Dyes; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D052160:Benzothiazoles; D005456:Fluorescent Dyes; D011804:Quinolines; C051000:thiazole orange