title: Subject specific finite element analysis of stress shielding around a cementless femoral stem.
abstract: BACKGROUND
  Stress shielding around a femoral stem is usually assessed experimentally using composite or human cadaver femurs. In the present study we have explored the feasibility of using subject specific finite element models to determine stress shielding in operated femurs.
  
  
  METHODS
  Cortical strain was measured experimentally on seven human cadaver femurs, intact and implanted with a straight cementless prosthesis. Two load configurations were considered: single leg stance and stair climbing. Subject specific finite element models derived from computed tomography of the same femurs were analysed intact and with an implant. Principal cortical strain was used to validate the finite element models. Stress shielding was defined as the change in equivalent (von Mises) strain between pre- and post-operative femurs.
  
  
  RESULTS
  Cortical strain predicted by the finite element analyses showed to be close to unity with the experimental observations for both intact (R2=0.94, slope=0.99), operated femurs (R2=0.86, slope=0.86) and stress shielding (R2=0.70, slope=0.90). In the proximal calcar area, the region most prone to periprosthetic remodelling, the finite element models were found to successfully reproduce the stress shielding observed experimentally.
  
  
  CONCLUSIONS
  The study shows that subject specific finite element models manage to describe the stress shielding pattern measured in vitro in the different femurs. Finite element models based on actual human femurs (cadaver and/or patient) could thus be a useful tool in the pre-clinical evaluation of new implants.
authors.affiliation: Department of Structural Engineering, Norwegian University of Science and Technology, 7491 Trondheim, Norway.
authors.forename: Sune H
authors.initials: SH
authors.lastname: Pettersen
authors.forename: Tina S
authors.initials: TS
authors.lastname: Wik
authors.forename: Bjørn
authors.initials: B
authors.lastname: Skallerud
mesh_terms: D000368:Aged; D002102:Cadaver; D002484:Cementation; D003198:Computer Simulation; D017076:Computer-Aided Design; D055119:Elastic Modulus; D019544:Equipment Failure Analysis; D005260:Female; D005270:Femur Head / Q000503:physiopathology* / Q000601:surgery*; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D011474:Prosthesis Design; D033081:Shear Strength; D013314:Stress, Mechanical