title: Fertility preserving surgery for carcinoma of the cervix.
abstract: OBJECTIVE
  Cervical cancer remains the second most common female malignancy. Screening programmes have reduced the overall incidence, predominantly in the western world; however, this has led to a disproportionate rise in the incidence of early-stage disease, with a related increase in demand, for fertility-sparing techniques to be developed.
  
  
  RESULTS
  Standard treatment for cervical cancer compromises fertility. A radical wide local excision of carefully selected early-stage tumours will allow conservation of the body of the uterus with a vaginoisthmic anastomosis enabling continuity of the vagina to be preserved following insertion of an isthmic cerclage suture. Pelvic node dissection may be performed at the same time by laparoscopic techniques. Over 900 cases have been performed and reported in the literature worldwide. Most have been carried out vaginally (radical vaginal trachelectomy and laparoscopic pelvic node dissection). A smaller number have been performed abdominally. There have been over 300 pregnancies reported with 196 live births. There has been a 10% significant prematurity rate with birth prior to 32 weeks. There have been 31 recurrences (4%), and 16 deaths (2%).
  
  
  CONCLUSIONS
  Radical vaginal trachelectomy appears safe when performed in centres with appropriate experience of radical vaginal surgery and laparoscopic techniques. The impact of this new approach questions traditional teaching, thus preserving potential fertility in up until now impossible circumstances.
authors.affiliation: Gynaecological Oncology Fellow, Royal Marsden Hospital, London, UK. David.milliken@rmh.nhs.uk
authors.forename: David A
authors.initials: DA
authors.lastname: Milliken
authors.forename: John H
authors.initials: JH
authors.lastname: Shepherd
mesh_terms: D005260:Female; D005298:Fertility; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*