title: Germinal-center T-helper-cell markers PD-1 and CXCL13 are both expressed by neoplastic cells in angioimmunoblastic T-cell lymphoma.
abstract: Gene expression profiling identified genes uniquely expressed by human germinal-center T-helper (GCTh) cells, including programmed death-1 (PD-1) and CXCL13. Recently, we demonstrated that PD-1 is an immunophenotypic marker of GCTh cells and angioimmunoblastic T-cell lymphoma (AITL). The goal of this study was to investigate the expression pattern of CXCL13 in comparison with PD-1. We studied 63 cases of T-cell lymphoproliferative disorders, including 22 cases of AITL. In cases of AITL, PD-1+ and CXCL13+ neoplastic cells were seen at foci of expanded CD21+ follicular dendritic cell networks. CXCL13 expression was limited in other peripheral T-cell lymphomas. PD-1 and CXCL13 identified germinal-center T-helper cells, showed a similar pattern of expression in AITL, and should serve as useful new markers for AITL. The similar pattern of expression of CXCL13 and PD-1 in AITL provides further evidence that AITL is a neoplasm derived from germinal-center T-helper cells.
authors.affiliation: Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Yu
authors.forename: Aliakbar
authors.initials: A
authors.lastname: Shahsafaei
authors.forename: David M
authors.initials: DM
authors.lastname: Dorfman
mesh_terms: D015703:Antigens, CD / Q000096:biosynthesis*; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis*; D054382:Chemokine CXCL13 / Q000096:biosynthesis*; D020869:Gene Expression Profiling; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000378:metabolism* / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000378:metabolism*; D061026:Programmed Cell Death 1 Receptor; D017464:Receptors, Complement 3d / Q000032:analysis; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D051017:Apoptosis Regulatory Proteins; C110663:CXCL13 protein, human; D054382:Chemokine CXCL13; C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor; D017464:Receptors, Complement 3d