title: Rituximab for refractory rheumatoid arthritis: a 24-week open-label prospective study.
abstract: OBJECTIVE
  To study the efficacy of rituximab in active rheumatoid arthritis (RA) patients refractory to disease modifying anti-rheumatic drugs (DMARDs) including the tumor necrosis factor (TNF)-alpha antagonists.
  
  
  METHODS
  Adult patients with active RA despite adequate therapies with conventional DMARDs or anti-TNFalpha agents for at least 3 months were recruited. Inclusion criteria were: (1) Positive RF / anti-CCP; (2) >/= 6 swollen joints and >/= 8 tender joints; (3) ESR >/= 28 mm/hr or CRP >/= 10 mg/L. Eligible patients were given intravenous rituximab infusions at a dose of 1000 mg on days 1 and 15. Assessment was performed 4-weekly thereafter and included tender joint counts (TJC), swollen joint counts (SJC), physician's and patient's global assessment, patient's pain assessment (VAS 0-100 mm), disability index (HAQ-DI), quality of life (SF36), fatigue score (FACIT-F), ESR and CRP. The DAS28, EULAR and ACR responses at week 24 were evaluated.
  
  
  RESULTS
  10 patients (8 women and 2 men) were studied (mean age: 49 years; mean RA duration 7.4 years). Baseline TJC and SJC were 25.1 +/- 13.2 and 12.8 +/- 5.4 respectively. The mean DAS28 score was 7.1 +/- 0.7, and the mean CRP and ESR levels were 52.3 +/- 60 mg/L and 95.8 +/- 32 mm/hr, respectively. The median number of failed DMARDs was 4 and two patients had failed anti-TNFalpha treatment. At week 24, there was a significant drop in TJC, SJC, ESR and CRP. The HAQ-DI score also decreased from 2.1 to 1.7 (p=0.04) while the total SF-36 score improved from 24.8 to 38.3 (p=0.008). Sixty percent of patients achieved EULAR moderate-to-good response. Half of the patients achieved ACR20 and two achieved ACR50 / 70 response. Only one patient experienced a minor infusion reaction.
  
  
  CONCLUSIONS
  Rituximab is effective and well tolerated in patients with refractory RA.
authors.affiliation: Department of Medicine and Geriatrics, Tuen Mun Hospital, Hong Kong SAR, China.
authors.forename: Ling Yin
authors.initials: LY
authors.lastname: Ho
authors.forename: Chi Chiu
authors.initials: CC
authors.lastname: Mok
authors.forename: Chi Hung
authors.initials: CH
authors.lastname: To
authors.forename: Mak
authors.initials: M
authors.lastname: Anselm
authors.forename: Mei Yuk
authors.initials: MY
authors.lastname: Cheung
authors.forename: Ka Lung
authors.initials: KL
authors.lastname: Yu