A new window onto translational repression by bacterial sRNAs.
In this issue of Molecular Cell, Bouvier et al. (2008) show that bacterial sRNAs can repress mRNA translation not only by binding to the Shine-Dalgarno element but also by base pairing anywhere within the first few codons of the protein-coding region.
Richards
Jamie
J
Kimmel Center for Biology and Medicine at the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA.
Belasco
Joel G
JG
D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D014176:Protein Biosynthesis; D012329:RNA, Bacterial / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism; D012475:Salmonella / Q000378:metabolism*
D001426:Bacterial Proteins; D012329:RNA, Bacterial; D012333:RNA, Messenger; D022661:RNA, Untranslated