Isolation and biological activities of neomyrrhaol and other terpenes from the resin of Commiphora myrrha.
A new cycloartane-type triterpene named cycloartane-1alpha,2alpha,3beta,25-tetraol (neomyrrhaol) (1), along with four known terpenes, sandaracopimaric acid (2), abietic acid (3), 2-methoxy-5-acetoxyfruranogermacr-1(10)-en-6-one (4), and dehydroabietic acid (5) have been isolated from the resin of COMMIPHORA MYRRHA. Their structures were elucidated by means of 1D, 2 D NMR and HR-mass spectroscopy. Compounds 2-5 are known compounds but not previously isolated from the resin of C. MYRRHA. Compounds 4 and 5 exhibited significant aromatase inhibiting activity with IC50 values at 0.2 microM and 0.3 microM, respectively. As shown in the MTT assay, 2, 3, 4, and 5 had inhibitory effects on HUVEC growth with IC50 values of 0.122 microM (2), 0.125 microM (3), 0.069 microM (5). Compounds 1-5 did not inhibit contraction of the isolated uterine and did not protect HUVEC from damage induced by H2O2 at the tested concentration.
Su
Shu-Lan
SL
Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, PR China.
Duan
Jin-Ao
JA
Tang
Yu-Ping
YP
Zhang
Xu
X
Yu
Li
L
Jiang
Feng-Rong
FR
Zhou
Wei
W
Luo
Dan
D
Ding
An-Wei
AW
D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D029744:Commiphora / Q000737:chemistry*; D003603:Cytotoxins / Q000737:chemistry / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D012116:Resins, Plant / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
D003603:Cytotoxins; D012116:Resins, Plant; D013729:Terpenes; D014315:Triterpenes; C540624:neomyrrhaol