title: [The extracytoplasmic protein quality control in bacterium Escherichia coli; the role of proteases and the folding factors].
abstract: The proper functioning of extracytoplasmic proteins requires their correct folding after translocation and reaching a proper destination within the cellular envelope. This process is supervised by the folding factors and proteases, which comprise the protein quality control system. The coordinated action of its components maintains the proper functioning of the cell under physiological conditions and enables the survival of bacteria under stress conditions. In the present work we provide the concise characteristics of the protein quality control system within the cellular envelope with the particular emphasize on the role of proteolysis in maintaining the cellular homeostasis.
authors.affiliation: University of Gdansk, Insitute of Biology, Department of Biochemistry, 24 Kładki St., 80-822 Gdansk, Poland. glonek@biotech.ug.gda.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Skórko-Glonek
authors.forename: Anna
authors.initials: A
authors.lastname: Sobiecka-Szkatuła
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D006706:Homeostasis / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D008565:Membrane Proteins / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D019696:Peptidylprolyl Isomerase / Q000378:metabolism; D017510:Protein Folding; D011786:Quality Control; D013312:Stress, Physiological / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D018832:Molecular Chaperones; C072721:Skp protein, E coli; D010447:Peptide Hydrolases; C530413:PpiD protein, E coli; C490900:SurA protein, E coli; D019696:Peptidylprolyl Isomerase; C068254:FkpA protein, E coli