title: Fracture-associated and idiopathic subchondral vertebral lesions: a magnetic resonance study in autopsy specimens with histologic correlation.
abstract: OBJECTIVE
  The aim of this study was to describe and compare the magnetic resonance (MR) and histological appearance of subchondral vertebral lesions that are idiopathic or that develop with vertebral fractures.
  
  
  METHODS
  T1- and T2-weighted spin-echo images and radiographs were obtained in 81 cadaveric spine specimens. All subchondral vertebral lesions that were considered to be idiopathic or associated with vertebral end plate fractures were selected. Lesions due to growth disturbance were excluded. Radiographs and MR images were analyzed in consensus by two radiologists, and sampled specimens were analyzed by a pathologist.
  
  
  RESULTS
  Eleven idiopathic and ten fracture-associated vertebral lesions were available. On T1-weighted images, all lesion signal intensity was low and homogeneous. On T2-weighted images, all idiopathic lesions showed a heterogeneous signal with a central low or intermediate signal component and a peripheral high or intermediate component. All but one fracture-related lesions showed a homogeneous intermediate to high signal intensity. Histological analysis of idiopathic lesions showed a central acellular fibrous connective tissue in all cases surrounded by loose connective tissue in nine cases. Herniated disk material and cartilage metaplasia were found in one lesion only. Fracture-associated lesions contained herniated disk material, necrotic tissue, and loose connective tissue with a peripheral component of loose fibrovascular connective tissue in four cases only.
  
  
  CONCLUSIONS
  MR and histological appearance of idiopathic and fracture-associated subchondral vertebral lesions differ, suggesting that they might have a different origin.
authors.affiliation: Department of Radiology, Cliniques Universitaires St Luc, Université Catholique de Louvain, 10 Avenue Hippocrate, 1200 Brussels, Belgium.
authors.forename: C A
authors.initials: CA
authors.lastname: Peters
authors.forename: B C
authors.initials: BC
authors.lastname: Vande Berg
authors.forename: C
authors.initials: C
authors.lastname: Galand
authors.forename: F E
authors.initials: FE
authors.lastname: Lecouvet
authors.forename: J
authors.initials: J
authors.lastname: Malghem
mesh_terms: D001344:Autopsy; D002102:Cadaver; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000473:pathology*