title: Application of multipotent mesenchymal stromal cells from human adipose tissue for compensation of neurological deficiency induced by 3-nitropropionic Acid in rats.
abstract: We evaluated possible therapeutic effect of multipotent mesenchymal stromal cells from human adipose tissue differentiated to neuronal phenotype with retinoic acid on Wistar rats subjected to toxic effect of 3-nitropropionic acid. Transplantation of mesenchymal stromal cells from human adipose tissue considerably decreased neurological symptoms, normalized exploratory activity (open field test) and long-term memory (Morris test), which correlated with normalization of pathomorphological manifestations in the brain. Destructive changes in the caudate nucleus caused by treatment with 3-nitropropionic acid (reduced size of neurons, changes in their shape, and cell edema) tended to decrease under the effect of multipotent mesenchymal stromal cells: the area of neurons increased 2-fold, the cells acquired typical round shape, cell edema decreased.
authors.affiliation: Research Center of Neurology, Russian Academy of Medical Sciences, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kulikov
authors.forename: M S
authors.initials: MS
authors.lastname: Stepanova
authors.forename: S L
authors.initials: SL
authors.lastname: Stvolinsky
authors.forename: R M
authors.initials: RM
authors.lastname: Hudoerkov
authors.forename: D N
authors.initials: DN
authors.lastname: Voronkov
authors.forename: A A
authors.initials: AA
authors.lastname: Rzhaninova
authors.forename: D V
authors.initials: DV
authors.lastname: Goldstein
authors.forename: A A
authors.initials: AA
authors.lastname: Boldyrev
mesh_terms: D000273:Adipose Tissue / Q000166:cytology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation / Q000662:veterinary; D059630:Mesenchymal Stem Cells / Q000166:cytology; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000628:therapy*; D009474:Neurons / Q000502:physiology; D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000166:cytology / Q000637:transplantation*
chemical_list: D009498:Neurotoxins; D009574:Nitro Compounds; D011422:Propionates; C015392:3-nitropropionic acid