[Study on T cell subsets in HIV/AIDS patients].
OBJECTIVE
Analyze Naive and Mermory T cell subsets in HIV/AIDS patients and investigate their relationship with disease development.


METHODS
T cell subsets from 15 normal control subjects, 79 HIV/ AIDS patients were detected by FCM.


RESULTS
With diesase progression, CD4+ Naive cell counts and ratio was both decreased obviously (P < 0.001); CD4+ Tcm cell counts was significantly decreased (P < 0.001), CD4+ Tcm cell ratio was obviously higher (P = 0.002); CD4 TEM cell ratio was obviously increased( P < 0.001); CD8+ T Naive cell counts and ratio was also decreased obviously (P < 0.05); CD8+ T(CM), T(EM), T(EMRA) are not significantly different.


CONCLUSIONS
The peripheral lymphocyte subsets in HIV/AIDS patients changed obviously. The counts of naive T cell decreased, while the proportion of memory T cell increased significantly. It will help to understand pathogenesis of HIV.
Li
Hai-Ying
HY
Beijing You'an Hospital, Capital Medical University, Beijing 100069 China.
Cao
Zhen-Huan
ZH
Ji
Yun-Xia
YX
Wu
Hao
H
Chen
Xin-Yue
XY
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D000328:Adult; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D005260:Female; D006678:HIV / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*