Effect of liposomal tetracycline hydrochloride on enzymatic function of the liver.
Preparation and physicochemical properties of liposome-incorporated tetracycline are described. Comparison of the effects of tetracycline hydrochloride in free and liposome-incorporated forms on enzymatic functions of the liver showed that immobilization of the antibiotic into liposomes protects liver cells from functional disturbances.
Tikhonov
S N
SN
Volgograd Research Antiplague Institute, Federal Service for Surveillance of Consumer Rights Protection and Human Well being, Russia. vari2@sprint-v.com.ru
Rotov
K A
KA
Khrapova
N P
NP
Alekseev
V V
VV
Snatenkov
E A
EA
Zamarin
A A
AA
Simakova
N A
NA
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D021461:Animals, Outbred Strains; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008081:Liposomes; D008099:Liver / Q000187:drug effects* / Q000201:enzymology*; D008110:Liver Extracts / Q000378:metabolism; D008111:Liver Function Tests; D051379:Mice; D006005:Phosphorylases / Q000378:metabolism; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D008081:Liposomes; D008110:Liver Extracts; D006005:Phosphorylases; D000469:Alkaline Phosphatase; D000251:Adenosine Triphosphatases; D013752:Tetracycline