[Urgent hemostatic control with Confact F for ovarian bleeding complicated by an unknown type of von Willebrand disease].
Emergency surgery was performed on a 24-year-old female patient with an unknown type of von Willebrand disease (VWD). The patient suddenly developed lower abdominal pain and was transported to our hospital by ambulance. Based on the diagnosis of ovarian bleeding, emergency surgery was indicated. Ristocetin-cofactor activity (VWF: RCo) was between 7% and 14% by measurement with von Willebrand reagent (Dade Behring, Marburg, Germany). A laparoscopic partial resection of the left ovary was performed under administration of factor VIII/VWF concentrate, Confact F((R)) (Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan). During and after surgery, there was no abnormal bleeding. The results obtained by measurement by the reagent were similar to the levels of VWF: RCo obtained by the fixed platelet agglutination method. The reagent was useful for diagnosing and monitoring the VWF: RCo level to control bleeding in VWD.
Suzuki
Takashi
T
Department of Laboratory Medicine, Tokyo Medical University, Japan.
Kagawa
Kazuhiko
K
Oishi
Tsuyoshi
T
Kawata
Kazuhide
K
Fujito
Atsuya
A
Isaka
Keiichi
K
Fukutake
Katsuyuki
K
D015415:Biomarkers / Q000097:blood; D005169:Factor VIII / Q000008:administration & dosage*; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000628:therapy*; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000209:etiology* / Q000628:therapy*; D010052:Ovariectomy; D011933:Reagent Kits, Diagnostic; D055815:Young Adult; D014842:von Willebrand Diseases / Q000150:complications*; D014841:von Willebrand Factor / Q000008:administration & dosage* / Q000032:analysis
D015415:Biomarkers; D006490:Hemostatics; D011933:Reagent Kits, Diagnostic; D014841:von Willebrand Factor; D005169:Factor VIII