title: The significance of angiogenic growth factor in the pathogenesis of gestosis in pregnant women with varicose disease.
abstract: Recently, a close relationship between angiogenesis processes, growth factor activity in vascular abnormalities, and gestosis was revealed. In the present study, the dynamics of serum vascular endothelial growth factor during pregnancy was studied in patients with varicose disease with and without gestosis and in healthy women. The level of vascular endothelial growth factor increased during normal pregnancy, but decreased in gestosis. In pregnant patients with varicose disease, a less pronounced increase in this parameter was observed in comparison with that in healthy women.
authors.affiliation: Department of Obstetrics, Gynecology, and Perinatology, Faculty of Upgrading of Pediatricians, I. M. Setchenov Moscow Medical Academy, Russia. angelasokolyan@mail.ru
authors.forename: A V
authors.initials: AV
authors.lastname: Sokolyan
authors.forename: A V
authors.initials: AV
authors.lastname: Murashko
authors.forename: L V
authors.initials: LV
authors.lastname: Krechetova
authors.forename: M M
authors.initials: MM
authors.lastname: Ziganshina
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D014648:Varicose Veins / Q000097:blood / Q000150:complications*; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000502:physiology*
chemical_list: D042461:Vascular Endothelial Growth Factor A