[Antiallergic effect of D-glucuronic acid].
The influence of D-glucuronic acid (course administration) on a Thl and Th2 immune response was studied. It is established that D-glucuronic acid suppressed Th2-dependent immune response as it decreased the lethality from the anaphylactic shock, abolished the local anaphylactic reaction and strongly inhibited allergen-specific IgE and IgG1 production. In addition, D-glucuronic acid stimulated Thl-dependent immune response since it enhanced the delay-type hypersensitivity reaction, increased amount of antibody-forming cells and the number of antibodies in blood. It is concluded that the mechanism of the antiallergic effect of D-glucuronic acid is related to a change in the Th1/Th2 balance in favor of Th1.
Danilets
M G
MG
Bel'skiĭ
Iu P
IuP
Bel'skaia
N F
NF
Trofimova
E S
ES
Uchasova
E G
EG
Ligacheva
A A
AA
Agafonov
V I
VI
D000707:Anaphylaxis / Q000188:drug therapy* / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects* / Q000276:immunology; D020723:Glucuronic Acid / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D018926:Anti-Allergic Agents; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D020723:Glucuronic Acid