Myocardial resistance to ischemic and reperfusion injuries under conditions of chronic administration of opioid receptor agonists and antagonists.
Chronic treatment with opioid receptor ligands: nonselective peptide opioid receptor agonist dalargin (intraperitoneally in a dose of 1 mg/kg), selective nonpeptide kappa-receptor agonist GR 89696 (subcutaneously in a dose of 0.03 mg/kg), nonselectrive nonpeptide antagonist quadazocine (subcutaneously in a dose of 3 mg/kg) or naltrexone (subcutaneously in a dose of 10 mg/kg) for 20 day had no effect of the incidence of ischemic ventricular arrhythmias and the size of necrotic zone after coronary occlusion and reperfusion in rats in vivo.
Lishmanov
Yu B
YB
Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Stakheev
D L
DL
Krylatov
A V
AV
Naryzhnaya
N V
NV
Maslov
L N
LN
Ovchinnikov
M V
MV
Kolar
F
F
D000818:Animals; D001392:Azocines / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists; D010879:Piperazines / Q000494:pharmacology; D011759:Pyrrolidines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000819:agonists*; D017465:Receptors, Opioid, delta / Q000819:agonists / Q000037:antagonists & inhibitors; D017473:Receptors, Opioid, kappa / Q000819:agonists / Q000037:antagonists & inhibitors; D017450:Receptors, Opioid, mu / Q000819:agonists / Q000037:antagonists & inhibitors
D001392:Azocines; D009292:Narcotic Antagonists; D010879:Piperazines; D011759:Pyrrolidines; D011957:Receptors, Opioid; D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; C071609:GR 89696; D009271:Naltrexone; D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-; C035969:quadazocine