title: Antifungal triterpene glycosides from the sea cucumber Bohadschia marmorata.
abstract: Four new holostan-type triterpene glycosides, marmoratoside A ( 1), 17 alpha-hydroxy impatienside A ( 2), marmoratoside B ( 3), 25-acetoxy bivittoside D ( 4), together with two known triterpene glycosides, impatienside A ( 5) and bivittoside D ( 6), were isolated from the sea cucumber Bohadschia Marmorata Jaeger. On the basis of spectroscopic analyses, including two-dimensional NMR techniques, and chemical reactions, the structures of the new triterpene glycosides were elucidated. Compounds 1, 2, 5, and 6 exhibited significant antifungal activity against six strains (0.70 < or = MIC (80) < or = 2.81 microM).
authors.affiliation: Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai, PR China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Yuan
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Bao-Shu
authors.initials: BS
authors.lastname: Liu
authors.forename: Zeng-Lei
authors.initials: ZL
authors.lastname: Wang
authors.forename: Guo-Quan
authors.initials: GQ
authors.lastname: Sun
authors.forename: Wen
authors.initials: W
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Sun
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes