title: Influence of prednisolone-induced osteoporosis on bone mass and bone quality of the mandible in rats.
abstract: OBJECTIVE
  The aim of this study was to clarify the effects of steroid treatment on the mandible.
  
  
  METHODS
  We divided 24 male Fisher rats, aged 10 weeks, into 2 groups: a control group (n = 11) and a prednisolone (Pred) treatment group (n = 13). The dose for the Pred group was 40 mg kg(-1) and was administered orally three times per week for 8 weeks. At the end of the experiment, we measured bone mass, bone strength and trabecular structure of the mandible and femur.
  
  
  RESULTS
  Pred treatment decreased cortical bone mineral content (BMC), cortical thickness, stress/strain index and tissue volume of the mandible. However, there were no marked changes in trabecular structure parameters. A strong correlation was seen between mandibular and femoral cortical BMC (r = 0.71).
  
  
  CONCLUSIONS
  These findings suggest that steroid treatment decreases the cortical BMC, bone area and bone strength of the mandible.
authors.affiliation: Department of Radiology, Kanagawa Dental College, Kanagawa, 238-8580, Japan. kozai@kdcnet.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Kozai
authors.forename: R
authors.initials: R
authors.lastname: Kawamata
authors.forename: T
authors.initials: T
authors.lastname: Sakurai
authors.forename: M
authors.initials: M
authors.lastname: Kanno
authors.forename: I
authors.initials: I
authors.lastname: Kashima
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D005269:Femur / Q000187:drug effects; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D008334:Mandible / Q000187:drug effects*; D010024:Osteoporosis / Q000139:chemically induced*; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D055114:X-Ray Microtomography
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone