title: Self-perception of side effects by adolescents in a chlorhexidine-fluoride-based preventive oral health program.
abstract: OBJECTIVE
  The objective of this study was to evaluate the incidence of adverse effects reported by adolescents following 14 days of use of a mouthrinse containing 0.05% NaF+0.12% chlorhexidine.
  
  
  METHODS
  This double-blind study was developed as part of a randomized clinical trial. The adolescents enrolled to the study were randomly divided into two groups to use either: 0.05% NaF+0.12% chlorhexidine (G1, n=85) or 0.05% NaF (G2, n=85). Both groups used a 10mL solution of the mouthwash during 1 minute daily for 2 weeks under supervision. After that period, the subject's acceptance of taste was measured using a verbal descriptive scale (Labeled Magnitude Scale - LMS). Participants were also interviewed regarding the occurrence of possible adverse effects during treatment (temporary palate disorders, tooth staining or unpleasant taste). The proportional differences between the groups were tested using the chi-square test.
  
  
  RESULTS
  Palate changes were reported by 26% of participants of each group; 17.7% of G1 and 32% of G2 reported an unpleasant taste (p = 0.062), while staining was reported by 55% of G1 and 68.9% of G2 (p = 0.117). Absenteeism rates were similar in both groups (G1= 2.58 +/- 2.69; G2=2.81 +/- 2.39), p=0.362.
  
  
  CONCLUSIONS
  Adherence was high in both groups and side effects reported by subjects were not perceived by them as being important. Since subjects' acceptance and compliance is fundamental to the success of an oral health program, chlorhexidine-fluoride could be a useful resource in a program of plaque control.
authors.affiliation: Department of Stomatology, Federal University of Santa Catarina. ardg1999@gmail.com
authors.forename: Ana Rita Duarte
authors.initials: AR
authors.lastname: Guimaraes
authors.forename: Marco Aurélio
authors.initials: MA
authors.lastname: Peres
authors.forename: Ricardo de Sousa
authors.initials: Rde S
authors.lastname: Vieira
authors.forename: Rodrigo Melin
authors.initials: RM
authors.lastname: Ferreira
authors.forename: Maria Letícia
authors.initials: ML
authors.lastname: Ramos-Jorge
authors.forename: Sara
authors.initials: S
authors.lastname: Apolinario
authors.forename: Anderson
authors.initials: A
authors.lastname: Debom