Investigation of detection limits for diffuse optical tomography systems: II. Analysis of slab and cup geometry for breast imaging.
Using a statistical (chi-square) test on simulated data and a realistic noise model derived from the system's hardware we study the performance of diffuse optical tomography systems for fluorescence imaging. We compare the predicted smallest size of detectable lesions at various positions in slab and cup geometry and model how detection sensitivity depends on breast compression and lesion fluorescence contrast. Our investigation shows that lesion detection is limited by relative noise in slab geometry and by absolute noise in cup geometry.
Ziegler
Ronny
R
Philips Research Europe-Hamburg, Röntgenstr. 24, 22335 Hamburg, Germany.
Brendel
Bernhard
B
Rinneberg
Herbert
H
Nielsen
Tim
T
D055592:Biophysical Phenomena; D001943:Breast Neoplasms / Q000175:diagnosis*; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D005456:Fluorescent Dyes; D006801:Humans; D008962:Models, Theoretical; D019047:Phantoms, Imaging / Q000706:statistics & numerical data; D017785:Photons; D012680:Sensitivity and Specificity; D041622:Tomography, Optical / Q000379:methods* / Q000706:statistics & numerical data
D003287:Contrast Media; D005456:Fluorescent Dyes