Organocatalyzed highly atom economic one pot synthesis of tetrahydropyridines as antimalarials.
A highly atom economic one pot synthesis of tetrahydropyridines was achieved by L-proline/TFA catalysed multicomponent reaction of beta-keto-esters, aromatic aldehydes and anilines. The synthesized compounds were screened against Plasmodium falciparum in vitro and one of them showed antimalarial activity with MIC as low as 0.09 microg/mL.
Misra
Mridul
M
Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, UP 226001, India.
Pandey
Swaroop Kumar
SK
Pandey
Vivek Parashar
VP
Pandey
Jyoti
J
Tripathi
Renu
R
Tripathi
Rama Pati
RP
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
D000962:Antimalarials; D011725:Pyridines