Some neuropharamacological effects of the crude extract of Conus parvatus in mice.
The present study was aimed to characterize the type of conotoxin present in Conus parvatus. (CP) belongs to family conidae, through neuro-pharmacological activities of the crude venom extract on some of the CNS animal experiment using mice as animal model. The effects of CP on CNS were studied, by using spontaneous motor activity, gross behavior, rota-rod performance, analgesic activity and potentiation of pentobarbitone sleeping time in mice. Preliminary evaluation of acute toxicity was also carried out; The LD50 value was found to be 425.20 mcg kg(-1) by i.p. route. The extract (200 mcg kg(-1) i.p.) was found to produce, reduction in spontaneous motor activity, potent analgesic activity, reduction in motor coordination and prolonged pentobarbitone-sleeping time. From the above all pharmacological activities, it may concluded that, the conotoxin present in CP is most likely to be a alpha-conotoxin and also it will be more suitable to continue the studies in the areas of analgesic and other CNS depressant therapeutic areas after isolation of the pure cono-peptide from CP.
Balamurgan
K
K
Department of Pharmacy, Annamalai University, Annamalai Nagar, Tamil Nadu, India.
Dey
Akalanka
A
Sivakumar
G
G
D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D020916:Conotoxins / Q000378:metabolism / Q000494:pharmacology*; D052078:Conus Snail / Q000378:metabolism*; D004195:Disease Models, Animal; D051379:Mice; D009048:Motor Skills / Q000187:drug effects; D009480:Neuropharmacology / Q000379:methods; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D023382:Toxicity Tests, Acute; D016896:Treatment Outcome
D000700:Analgesics; D020916:Conotoxins; D010424:Pentobarbital