Dysrulation of T cell peripheral tolerance in type 1 diabetes.
Type 1 diabetes (T1D) is a T cell-mediated autoimmune disease in which the insulin producing beta cells are destroyed. The breakdown of beta cell-specific self-tolerance by T cells involves a number of dysregulated events intrinsic and extrinsic to T cells. Herein, we review the key mechanisms that drive beta cell autoimmunity, with an emphasis on events that influence the expansion and differentiation of pathogenic T cells in the periphery.
Tisch
R
R
Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, North Carolina, USA.
Wang
B
B
D000818:Animals; D015551:Autoimmunity; D003713:Dendritic Cells / Q000502:physiology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D050417:Insulin-Secreting Cells / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD; D013601:T-Lymphocytes / Q000276:immunology*