Unilateral Candida parapsilosis interface keratitis after laser in situ keratomileusis: case report and review of the literature.
OBJECTIVE
To describe a rare case of early-onset Candida parapsilosis infection after laser in situ keratomileusis (LASIK) and review the published reports of post-LASIK fungal infections.


METHODS
A 32-year-old woman presented with interface infiltration in the central interface in the right eye 2 days after LASIK surgery. The right eye flap was lifted, and the opacities were scraped. Two days later, a 3- x 3-mm-dense oval opacity and diffuse hazes were noted. Surgical intervention was arranged because of suspicion of interface infectious keratitis.


RESULTS
After an apparent post-LASIK keratitis with related interface inflammation failed to respond to medical therapy, corneal culture results were positive for C. parapsilosis 2 weeks 6 days after presentation. The patient was started on topical drops of amphotericin B 0.15% every hour after the smear showed the presence of yeast. The opacities decreased, and the topical antifungal drops were tapered. One month later, her uncorrected visual acuity recovered to 20/20.


CONCLUSIONS
Candida parapsilosis interface keratitis after LASIK may occur in the early phase. Early diagnosis and proper treatment can result in good outcome.
Chen
Wen-Lu
WL
Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan.
Tsai
Yi-Yu
YY
Lin
Jane-Ming
JM
Chiang
Chun-Chi
CC
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage; D000935:Antifungal Agents / Q000008:administration & dosage; D002177:Candidiasis / Q000188:drug therapy; D003318:Corneal Opacity / Q000382:microbiology / Q000473:pathology / Q000601:surgery; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007634:Keratitis / Q000209:etiology* / Q000382:microbiology*; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D009883:Ophthalmic Solutions
D000935:Antifungal Agents; D009883:Ophthalmic Solutions; D000666:Amphotericin B