[Mycological diagnosis: something is changing].
Great effort has been made in recent years to develop molecular techniques for laboratory diagnosis of mycosis. To this end, elucidation of the entire genomic sequence of the main fungal pathogens provides an unprecedented opportunity for clinical mycologists. There is considerable expectation regarding the potential application of the rapid advances in genomics and proteomics to study the molecular basis of fungal pathogenicity, to search for new and more effective antifungal drugs, and to identify fungal antigens. This article reviews the key aspects of fungal genomics and presents genomic and post-genomic applications of interest for clinical mycologists.
Alvarez-Pérez
Sergio
S
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
García
Marta Eulalia
ME
Blanco
José Luis
JL
D055028:Comparative Genomic Hybridization; D019295:Computational Biology; D004252:DNA Mutational Analysis; D004271:DNA, Fungal / Q000235:genetics; D016681:Genome, Fungal; D023281:Genomics / Q000458:organization & administration; D006801:Humans; D025202:Molecular Diagnostic Techniques / Q000639:trends*; D009172:Mycology / Q000639:trends*; D009181:Mycoses / Q000175:diagnosis*; D036103:Nanotechnology; D040901:Proteomics / Q000458:organization & administration
D004271:DNA, Fungal