title: CD44 keeps tumor killers polarized.
abstract: In this issue of Immunity, Mrass et al. (2008) report that CD44 critically contributes to the stabilization of polarity in migrating cytotoxic T lymphocytes by anchoring cytoskeletal proteins to the cell membrane at their uropods.
authors.affiliation: Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA. tmempel@mgh.harvard.edu
authors.forename: Thorsten R
authors.initials: TR
authors.lastname: Mempel
authors.forename: Francesco
authors.initials: F
authors.lastname: Marangoni
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism*; D002465:Cell Movement; D016764:Cell Polarity / Q000276:immunology; D003598:Cytoskeletal Proteins / Q000276:immunology / Q000378:metabolism*; D003599:Cytoskeleton / Q000276:immunology / Q000378:metabolism*; D018960:Hyaluronan Receptors / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000378:metabolism
chemical_list: D003598:Cytoskeletal Proteins; D018960:Hyaluronan Receptors