title: [A partial response to combined S-1 and CDDP chemotherapy enabling a curative resection in a patient with locally advanced duodenal cancer].
abstract: A 60-year-old male presented with a primary complaint of back pain. CT revealed a primary duodenal tumor with bulky lymph node metastases. Gastrofiberscopy revealed a primary duodenal tumor located the second portion. The patient was treated with combined chemotherapy using S-1 and CDDP to prior to performing a surgical curative resection. S-1 (80 mg/m2) was orally administered for 3 weeks (day 1-21), and CDDP (60 mg/m2) was simultaneously administered on day 8 every 5 weeks. The chemotherapy was repeated for 2 cycles. The patient experienced no adverse event. CT revealed a partial response after chemotherapy. The patient underwent a curative pancreaticoduodenectomy. The pathological efficacy was Grade 2. Adjuvant chemotherapy was provided using S-1 regimen because of its pathological efficacy and the absence of severe adverse events. Six months after the operation, the patient was doing well and showed no signs of recurrence of the cancer. This S-1/CDDP combination chemotherapy was therefore considered to be suitable as neo-adjuvant chemotherapy because it permitted the patient to subsequently undergo a curative resection, and thereby achieving a survival benefit for locally advanced duodenal cancer.
authors.affiliation: Dept. of Surgery, Saiseikai Yokohamashi Tobu Hospital.
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Egawa
authors.forename: Masaki
authors.initials: M
authors.lastname: Ohashi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Shinobu
authors.initials: S
authors.lastname: Hayashi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Doi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagashima
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use*; D004338:Drug Combinations; D004379:Duodenal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D004384:Duodenoscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D012074:Remission Induction; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin