title: Pregnancy outcome after ultrasound diagnosis of fetal intra-abdominal umbilical vein varix.
abstract: OBJECTIVE
  Fetal intra-abdominal umbilical vein (FIUV) varix is a focal dilatation of the intra-abdominal portion of the umbilical vein, which has been reported to be associated with intrauterine death and other anomalies. Our aim was to examine our experience with this diagnosis at a single tertiary-care center and to correlate it with clinical outcome.
  
  
  METHODS
  This was a retrospective case series study. Our ultrasound database was searched for all cases with a diagnosis of FIUV varix identified at our facility between 1997 and 2007. We reviewed all ultrasound examinations, maternal antenatal records, delivery records and newborns' medical records.
  
  
  RESULTS
  We identified 52 cases of FIUV among a population of approximately 68,000. Three cases of trisomy 21 were identified, all of which were accompanied by other anomalies. There was intrauterine death of one fetus with trisomy 21 at 35 weeks of gestation. We did not find an association between FIUV varix and other obstetric complications.
  
  
  CONCLUSIONS
  The outcome of pregnancies with FIUV varix is generally favorable. The finding of a FIUV varix should prompt the search for other anomalies, especially markers of aneuploidy.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, The University of Texas Medical Branch, Galveston, TX 77573, USA. bebyers@utmb.edu
authors.forename: B D
authors.initials: BD
authors.lastname: Byers
authors.forename: N
authors.initials: N
authors.lastname: Goharkhay
authors.forename: J
authors.initials: J
authors.lastname: Mateus
authors.forename: K K
authors.initials: KK
authors.lastname: Ward
authors.forename: M B
authors.initials: MB
authors.lastname: Munn
authors.forename: T S
authors.initials: TS
authors.lastname: Wen
mesh_terms: D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D005260:Female; D005333:Fetus / Q000002:abnormalities / Q000098:blood supply* / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011379:Prognosis; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal; D014471:Umbilical Veins / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014648:Varicose Veins / Q000000981:diagnostic imaging*; D055815:Young Adult