Skeletal muscle capillarization and oxidative metabolism in healthy smokers.
We investigated whether the lower fatigue resistance in smokers than in nonsmokers is caused by a compromised muscle oxidative metabolism. Using calibrated histochemistry, we found no differences in succinate dehydrogenase (SDH) activity, myoglobin concentration, or capillarization in sections of the vastus lateralis muscle between smokers and nonsmokers. The relationship between fatigue resistance and SDH activity in nonsmokers (r = 0.93; p = 0.02) is absent in smokers. This indicates that the lower muscle fatigue resistance of smokers can likely be attributed to causes other than differences in oxidative metabolism and capillarization.
Wüst
Rob C I
RC
Institute for Biomedical Research into Human Movement and Health, Manchester Metropolitan University, John Dalton Building, Chester Street, Manchester, M1 5 GD, UK.
Jaspers
Richard T
RT
van der Laarse
Willem J
WJ
Degens
Hans
H
D000328:Adult; D000368:Aged; D001706:Biopsy; D002196:Capillaries / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018763:Muscle Fatigue / Q000187:drug effects; D018485:Muscle Fibers, Skeletal / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000187:drug effects / Q000378:metabolism*; D009211:Myoglobin / Q000187:drug effects / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D055815:Young Adult
D009211:Myoglobin; D013385:Succinate Dehydrogenase; D010100:Oxygen