title: Bupropion-associated QRS prolongation unresponsive to sodium bicarbonate therapy.
abstract: We describe a case of bupropion-associated QRS prolongation that was unresponsive to intravenous bolus therapy of sodium bicarbonate. Bupropion may cause seizures and conduction delays similar to tricyclic antidepressants in the overdose setting by an unknown mechanism.
authors.affiliation: Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA, USA.
authors.forename: Brandon K
authors.initials: BK
authors.lastname: Wills
authors.forename: Michele
authors.initials: M
authors.lastname: Zell-Kanter
authors.forename: Steven E
authors.initials: SE
authors.lastname: Aks
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D016642:Bupropion / Q000506:poisoning*; D018765:Dopamine Uptake Inhibitors / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D000931:Antidotes; D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D017693:Sodium Bicarbonate