title: Improved regional function after autologous bone marrow-derived stem cell transfer in patients with acute myocardial infarction: a randomized, double-blind strain rate imaging study.
abstract: OBJECTIVE
  To investigate whether intracoronary transfer of bone marrow progenitor cells (BMPCs) early after reperfusion of an acute myocardial infarction improves regional myocardial function in a randomized double-blind, placebo-controlled strain rate imaging study.
  
  
  RESULTS
  Regional myocardial deformation was measured using velocity-derived strain rate imaging in 67 STEMI patients randomized 1:1 to intracoronary infusion of BMPC (n = 33) or placebo (n = 34). Myocardial segments were grouped into infarct (n = 232), border (n = 250), and remote (n = 526) based on MRI-delayed enhancement and the perfusion territory of the infarct-related vessel. Four months after revascularization and progenitor cell/placebo transfer, regional myocardial deformation (rate) improved significantly more in the infarct segments of BMPC patients (treatment effect on end-systolic strain: -3.7 +/- 1.0%, P = 0.0003; peak-systolic strain rate: -0.20 +/- 0.07 s(-1), P = 0.0035). These findings were confirmed by a significantly greater improvement of longitudinal mitral valve ring displacement in the infarct walls of BMPC patients (treatment effect: 0.93 mm, P = 0.034).
  
  
  CONCLUSIONS
  Intracoronary infusion of BMPC early after reperfusion of a STEMI improves recuperation of regional myocardial function at 4 months' follow-up. Quantitative assessment of regional systolic function might be more sensitive than global LV ejection fraction for the evaluation of BMPC therapy after STEMI.
authors.affiliation: Department of Cardiology, Gasthuisberg University Hospital, University of Leuven, 49 Herestraat, B-3000 Leuven, Belgium. lieven.herbots@uz.kuleuven.ac.be
authors.forename: Lieven
authors.initials: L
authors.lastname: Herbots
authors.forename: Jan
authors.initials: J
authors.lastname: D'hooge
authors.forename: Elif
authors.initials: E
authors.lastname: Eroglu
authors.forename: Daisy
authors.initials: D
authors.lastname: Thijs
authors.forename: Javier
authors.initials: J
authors.lastname: Ganame
authors.forename: Piet
authors.initials: P
authors.lastname: Claus
authors.forename: Christophe
authors.initials: C
authors.lastname: Dubois
authors.forename: Koen
authors.initials: K
authors.lastname: Theunissen
authors.forename: Jan
authors.initials: J
authors.lastname: Bogaert
authors.forename: Joseph
authors.initials: J
authors.lastname: Dens
authors.forename: Maria
authors.initials: M
authors.lastname: Kalantzi
authors.forename: Steven
authors.initials: S
authors.lastname: Dymarkowski
authors.forename: Bart
authors.initials: B
authors.lastname: Bijnens
authors.forename: Ann
authors.initials: A
authors.lastname: Belmans
authors.forename: Marc
authors.initials: M
authors.lastname: Boogaerts
authors.forename: George
authors.initials: G
authors.lastname: Sutherland
authors.forename: Frans
authors.initials: F
authors.lastname: Van de Werf
authors.forename: Frank
authors.initials: F
authors.lastname: Rademakers
authors.forename: Stefan
authors.initials: S
authors.lastname: Janssens
mesh_terms: D000368:Aged; D016026:Bone Marrow Transplantation; D003326:Coronary Circulation / Q000502:physiology; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D013318:Stroke Volume / Q000502:physiology; D016896:Treatment Outcome; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery