title: Ultrasonography for suspected deep vein thrombosis: how useful is single-point augmentation?
abstract: OBJECTIVE
  To assess the role of single-point augmentation of spectral Doppler flow in the diagnosis of acute deep vein thrombosis (DVT). Secondary objectives included identifying the augmentation response in non-DVT diagnoses.
  
  
  METHODS
  Patients attending the ultrasound departments of two hospitals for investigation of suspected acute DVT during an 8-month period were recruited to the study group. Spectral Doppler assessment of the superficial femoral vein was recorded during Valsalva and calf compression manoeuvres in the asymptomatic and symptomatic legs. The Doppler waveforms from the symptomatic limb were characterized as "normal" or "abnormal" by the operator. Standard compression ultrasonography of the symptomatic leg was then performed with the presence of DVT or an alternative diagnosis documented.
  
  
  RESULTS
  One hundred and sixty-seven patients underwent ultrasound examinations using the study methodology. Nine patients were subsequently excluded due to bilateral DVT or inability to tolerate calf compression. The mean age of the remaining 158 patients was 65.4 years with 28 DVTs identified (18% of patients). Calf compression elicited a normal response in 118/130 of non-DVT examinations (specificity 91%) and an abnormal response in 18/28 DVT examinations (sensitivity 64%). Diminished or absent augmentation was identified in alternative diagnoses that included haematoma and Baker's cyst.
  
  
  CONCLUSIONS
  This study demonstrates that single-point augmentation has a low sensitivity in suspected lower-limb DVT, and that the majority of undetected DVTs are isolated to the calf veins. An abnormal augmentation response is a poor predictor of lower-limb DVT as alternative diagnoses can produce diminished or reduced augmentation. Therefore, single-point augmentation does not add to the standard compression ultrasound examination for suspected DVT and should not be routinely performed.
authors.affiliation: Department of Radiology, Freeman Hospital, Newcastle upon Tyne, UK. andrewmcqueen7@hotmail.com
authors.forename: A S
authors.initials: AS
authors.lastname: McQueen
authors.forename: S T
authors.initials: ST
authors.lastname: Elliott
authors.forename: M J
authors.initials: MJ
authors.lastname: Keir
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003250:Constriction; D005268:Femoral Vein / Q000000981:diagnostic imaging; D006801:Humans; D035002:Lower Extremity / Q000098:blood supply / Q000000981:diagnostic imaging; D008875:Middle Aged; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D012680:Sensitivity and Specificity; D018615:Ultrasonography, Doppler, Color / Q000379:methods; D014636:Valsalva Maneuver; D020246:Venous Thrombosis / Q000000981:diagnostic imaging*