Pregnancy-associated colon and rectal cancer: perinatal and cancer outcomes.
OBJECTIVE
Assess the impact of colorectal cancer on maternal and neonatal outcomes.


METHODS
Cases were identified using several computer-generated linkage analyses. Maternal and newborn hospital discharges in California were linked to birth and if applicable infant death certificate records. This database was then linked to the California Cancer Registry, to create a cohort of women with pregnancy-associated colon and rectal cancer. This cohort was compared to pregnant women in California without colorectal cancer. Our secondary comparison was to non-pregnant, Californian women with colorectal cancer who could be aged-matched.


RESULTS
Women with pregnancy-associated colorectal cancer were more likely to undergo cesarean section (OR: 1.9) and to develop puerperal infections (OR: 2.8). In addition, higher rates of preterm delivery were found both secondary to scheduled deliveries and preterm labor (OR for preterm labor, 2.8). Neonatal outcomes were fairly similar between the two groups. Pregnancy was not found to have a significant effect on survival (HR: 0.73).


CONCLUSIONS
We found that women with pregnancy-associated colorectal cancer had excellent maternal and neonatal outcomes. This is likely secondary to the fact that most women are diagnosed after delivery. In addition, survival is similar between pregnancy-associated and non-pregnancy associated cases.
Dahling
Mary T
MT
Department of Obstetrics and Gynecology, University of California Davis, School of Medicine, CA, USA.
Xing
Guibo
G
Cress
Rosemary
R
Danielsen
Beate
B
Smith
Lloyd H
LH
D000328:Adult; D002140:California / Q000453:epidemiology; D002277:Carcinoma / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D011256:Pregnancy Outcome; D012004:Rectal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors