title: Assessment of the efficacy of bio-absorbable oxidized regenerated cellulose for prevention of post-operative pericardial adhesion in the rabbit model.
abstract: Pericardial adhesions complicate re-operative cardiac surgery and several attempts have been made to reduce adhesion formation. The efficacy of bio-absorbable oxidized regenerated cellulose in preventing post-operative pericardial adhesions was evaluated in the present study. Forty New Zealand white rabbits were divided into four groups of 10. In all rabbits an area of pericardium (2 x 2 cm) was excised. The wound was left open in groups 1 and 2 but replaced with bio-absorbable oxidized regenerated cellulose in groups 3 and 4. Rabbits in groups 1 and 3 were killed 3 weeks after surgery and those in groups 2 and 4 were killed at 6 weeks. Groups 1 and 2 showed more severe pericardial adhesions, more fibrous reaction and increased visibility of coronary vessels than groups 3 and 4, although there was no difference in inflammation. Light microscopy showed a mesothelium-like cell layer in groups 3 and 4. It is concluded that bio-absorbable oxidized regenerated cellulose may be suitable in patients receiving staged cardiac surgery and in those with a high probability of re-operation.
authors.affiliation: Department of Cardiovascular Surgery, Faculty of Medicine, Uludağ University, Bursa, Turkey. mbicer23@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Biçer
authors.forename: A S
authors.initials: AS
authors.lastname: Bayram
authors.forename: O
authors.initials: O
authors.lastname: Gürbüz
authors.forename: I
authors.initials: I
authors.lastname: Senkaya
authors.forename: O
authors.initials: O
authors.lastname: Yerci
authors.forename: M
authors.initials: M
authors.lastname: Tok
authors.forename: E
authors.initials: E
authors.lastname: Anğ
authors.forename: E B
authors.initials: EB
authors.lastname: Moğol
authors.forename: D
authors.initials: D
authors.lastname: Saba
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D002482:Cellulose / Q000031:analogs & derivatives*; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D003331:Coronary Vessels / Q000473:pathology; D004195:Disease Models, Animal; D005355:Fibrosis; D006490:Hemostatics / Q000627:therapeutic use*; D010496:Pericardium / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D011817:Rabbits; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*; D014945:Wound Healing
chemical_list: D002483:Cellulose, Oxidized; D006490:Hemostatics; D002482:Cellulose