The unique simultaneous occurrence of a squamous cell carcinoma and a granular cell tumor of the tongue at the same site: a histological and immunohistochemical study.
We report a case of a 47-year-old man with a granular cell tumor (GCT) of the tongue colocalized with a squamous cell carcinoma. To our knowledge, this is the first case to be reported in the literature with such an association. Furthermore, we performed an immunohistochemical analysis with p63 to distinguish pseudoepitheliomatous hyperplasia from invasive squamous cell carcinoma. Clinicians and pathologists must be made aware of this potential diagnostic pitfall so that the workup of a tongue lesion does not end prematurely with a benign diagnosis of granular cell tumor with overlying pseudoepitheliomatous hyperplasia.
Caltabiano
Rosario
R
Department G.F. Ingrassia, Section of Anatomic Pathology, and daggerDepartment of Surgery, University of Catania, Catania, Italy.
Cappellani
Alessandro
A
Di Vita
Maria
M
Lanzafame
Salvatore
S
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004848:Epithelium / Q000473:pathology; D005500:Follow-Up Studies; D016586:Granular Cell Tumor / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000032:analysis; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D009361:Neoplasm Invasiveness; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D014062:Tongue Neoplasms / Q000473:pathology*
C081876:CKAP4 protein, human; D008565:Membrane Proteins; D009418:S100 Proteins