title: Narrowband ultraviolet B and medium-dose ultraviolet A1 are equally effective in the treatment of moderate to severe atopic dermatitis.
abstract: BACKGROUND
  Phototherapy may be effective in atopic dermatitis (AD). Medium-dose (MD) ultraviolet (UV) A1 was introduced for the treatment of AD. Few immunohistochemical data are available pertaining to phototherapy in AD. Regulatory T cells may play a role in clearing AD.
  
  
  OBJECTIVE
  We sought to compare the clinical and immunohistochemical effects of narrowband (NB) UVB and MD UVA1 treatment in patients with AD.
  
  
  METHODS
  Thirteen adult patients with AD were included in this randomized investigator-blinded half-sided comparison study between NB UVB and MD UVA1. Disease activity was measured using the Leicester sign score. Skin biopsy specimens were taken before and after phototherapy. Regulatory T cells were stained with the forkhead box protein P3 (FoxP3).
  
  
  RESULTS
  NB UVB and MD UVA1 both significantly decreased AD severity (P < .01) and the dermal cellular infiltrate. The percentage of FoxP3(+)CD3(+) T cells did not change after NB UVB or MD UVA1 treatment.
  
  
  CONCLUSIONS
  MD UVA1 therapy was given 3 times per week instead of the preferred regimen of 5 times per week. This was necessary to achieve good blinding of the study.
  
  
  CONCLUSIONS
  NB UVB and MD UVA1 seem equally effective in the treatment of patients with moderate to severe AD. Neither MD UVA1 nor NB UVB had an effect on the percentage of FoxP3(+)CD3(+) T cells.
authors.affiliation: Department of Dermatology and Allergology, University Medical Center Utrecht, The Netherlands.
authors.forename: I M Leonie
authors.initials: IM
authors.lastname: Majoie
authors.forename: J Marja
authors.initials: JM
authors.lastname: Oldhoff
authors.forename: Huib
authors.initials: H
authors.lastname: van Weelden
authors.forename: Marloes
authors.initials: M
authors.lastname: Laaper-Ertmann
authors.forename: Mente T
authors.initials: MT
authors.lastname: Bousema
authors.forename: Vigfus
authors.initials: V
authors.lastname: Sigurdsson
authors.forename: Edward F
authors.initials: EF
authors.lastname: Knol
authors.forename: Carla A F
authors.initials: CA
authors.lastname: Bruijnzeel-Koomen
authors.forename: Marjolein S
authors.initials: MS
authors.lastname: de Bruin-Weller
mesh_terms: D000328:Adult; D003876:Dermatitis, Atopic / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016037:Single-Blind Method; D014467:Ultraviolet Therapy; D055815:Young Adult