Amyloid beta concentrations in older people with Down syndrome and dementia.
People with Down syndrome develop Alzheimer's disease with an early age of onset. Plasma amyloid beta (Abeta) levels were measured in individuals with Down syndrome who were over the age of 40. No associations between age and Abeta1-40 and Abeta1-42 concentrations were found and nor were Abeta1-40 and Abeta1-42 levels found to vary between those with Alzheimer's-type dementia and those without dementia. The APOE genotype was not found to have an impact upon Abeta1-40 or Abeta1-42 concentrations. These data suggest that other factors play important roles in determining the onset and progression of dementia in the Down syndrome population.
Jones
Emma L
EL
Wolfson Centre for Age-related Disease, Wolfson CARD, Guy's Campus, King's College London, London SE1 1UL, United Kingdom. emma.3.jones@kcl.ac.uk <emma.3.jones@kcl.ac.uk>
Hanney
Marisa
M
Francis
Paul T
PT
Ballard
Clive G
CG
D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000032:analysis / Q000097:blood*; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D015897:Comorbidity; D004314:Down Syndrome / Q000097:blood* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000032:analysis / Q000097:blood; D012737:Sex Factors
D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D015415:Biomarkers; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C075222:amyloid beta-protein (1-42)