The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice.
Innate immunity is mediated, at least in part, through a number of receptors known as Toll-like receptors (TLRs), which are activated by different microbial stimuli. Adaptive immunity, including autoimmunity, follows the innate response in a more specific manner. To investigate the roles of TLR3 and TLR9 in the development of type 1 diabetes, we generated NOD mice that are deficient in TLR3 and 9, respectively. There was no obvious difference in the incidence of spontaneous diabetes between TLR3-deficient mice and TLR3 heterozygous mice. However, TLR9-deficient mice were markedly protected from the disease compared to TLR9 heterozygous mice. Our results suggest that different TLRs play a varying role in autoimmune diseases.
Wong
F Susan
FS
Department of Cellular and Molecular Medicine, Bristol University, Bristol, United Kingdom.
Hu
Changyun
C
Zhang
Li
L
Du
Wei
W
Alexopoulou
Lena
L
Flavell
Richard A
RA
Wen
Li
L
D000367:Age Factors; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D051379:Mice; D016688:Mice, Inbred NOD; D018345:Mice, Knockout; D051196:Toll-Like Receptor 3 / Q000235:genetics / Q000502:physiology*; D051217:Toll-Like Receptor 9 / Q000235:genetics / Q000502:physiology*
C519703:TLR3 protein, mouse; C495370:Tlr9 protein, mouse; D051196:Toll-Like Receptor 3; D051217:Toll-Like Receptor 9