[The role of ABC transporters in the renal elimination of organic anions and drugs].
The ATP-binding cassette (ABC) transporters are a large superfamily of integral membrane proteins that actively transport organic ions across biological membranes. These transporters play important role in the reabsorptive and excretory capacity of the kidney. Nine structurally and functionally related members (MRP1-7, P-gp, BCRP) have been identified, which differ from each other by their localization, expression levels, and substrate specificity. This review discusses current knowledge on the renal characteristics of ABC transporters, with specific focus on their regulation.
Piwkowska
Agnieszka
A
Laboratory of Cellular and Molecular Nephrology, Polish Academy of Sciences Medical Research Center, 7 Debinki St., 80-211 Gdansk, Poland. apiwkowska@cmdik.pan.pl
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000042:Absorption; D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000838:Anions / Q000493:pharmacokinetics*; D002352:Carrier Proteins / Q000378:metabolism; D007668:Kidney / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000378:metabolism; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism; D010599:Pharmacokinetics; D014527:Uric Acid / Q000378:metabolism
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D018528:ATP-Binding Cassette Transporters; D048868:Adaptor Proteins, Signal Transducing; D000838:Anions; D002352:Carrier Proteins; D026901:Membrane Transport Proteins; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D014527:Uric Acid