title: The European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire for patients with bone metastases: the EORTC QLQ-BM22.
abstract: OBJECTIVE
  The aim of this study was to develop a bone metastases module to supplement the European Organisation for Research and Treatment of Cancer Core Questionnaire (EORTC QLQ-C30) or the EORTC QLQ-C15-PAL for patients with bone metastases.
  
  
  METHODS
  Phases 1-2 of module development were conducted in Canada, Australia and Germany according to EORTC QOL group guidelines. Phase 3 was conducted in nine countries in seven languages.
  
  
  RESULTS
  Sixty-one health-related quality of life (HRQOL) issues were generated from health care professionals (n=152) and patients (n=413). This resulted in a 22-item provisional module. Further testing in 170 patients from nine countries resulted in the EORTC QLQ-BM22 module, containing 22 items, conceptualised into both symptom scales, with five painful sites and three pain characteristics, and also functional scales, with eight functional interference and six psychosocial aspects.
  
  
  CONCLUSIONS
  This study provides a provisional comprehensive HRQOL measurement tool for future trials, which will continue to undergo further validation.
authors.affiliation: Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5. Electronic address: edward.chow@sunnybrook.ca.
authors.forename: Edward
authors.initials: E
authors.lastname: Chow
authors.affiliation: Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.
authors.forename: Amanda
authors.initials: A
authors.lastname: Hird
authors.affiliation: Cancer Research UK Clinical Centre, University of Leeds, St James's University Hospital, Leeds, UK.
authors.forename: Galina
authors.initials: G
authors.lastname: Velikova
authors.affiliation: University Surgical Unit, Southampton General Hospital, UK.
authors.forename: Colin
authors.initials: C
authors.lastname: Johnson
authors.affiliation: European Organization for Research and Treatment of Cancer, Brussel, Belgium.
authors.forename: Linda
authors.initials: L
authors.lastname: Dewolf
authors.affiliation: Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Andrea
authors.initials: A
authors.lastname: Bezjak
authors.affiliation: Tom Baker Cancer Centre, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Jackson
authors.initials: J
authors.lastname: Wu
authors.affiliation: Liverpool Hospital, Liverpool, New South Wales, Australia.
authors.forename: Jesmin
authors.initials: J
authors.lastname: Shafiq
authors.affiliation: Charité, Universitaetsmedizin Berlin, Germany.
authors.forename: Orhan
authors.initials: O
authors.lastname: Sezer
authors.affiliation: University of Patras Medical School, Patras, Greece.
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kardamakis
authors.affiliation: Radiotherapeutic Institute Friesland, Leeuwarden, The Netherlands.
authors.forename: Yvette
authors.initials: Y
authors.lastname: van der Linden
authors.affiliation: Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, China.
authors.forename: Brigette
authors.initials: B
authors.lastname: Ma
authors.affiliation: Instituto de Oncologia Angel H. Roffo, Universidad de Buenos Aires, Argentina.
authors.forename: Monica
authors.initials: M
authors.lastname: Castro
authors.affiliation: Hospital de l'Esperança, Sant Josep de la Muntanya, Barcelona, Spain.
authors.forename: Palmira Foro
authors.initials: PF
authors.lastname: Arnalot
authors.affiliation: St Lukes Hospice, Little Common Lane, Sheffield, UK.
authors.forename: Sam
authors.initials: S
authors.lastname: Ahmedzai
authors.affiliation: Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Mark
authors.initials: M
authors.lastname: Clemons
authors.affiliation: Mount Vernon Hospital, Northwood, Middlesex, UK.
authors.forename: Peter
authors.initials: P
authors.lastname: Hoskin
authors.affiliation: Sunnybrook Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.
authors.forename: Albert
authors.initials: A
authors.lastname: Yee
authors.affiliation: Kingston Regional Cancer Centre, Kingston, Ontario, Canada.
authors.forename: Michael
authors.initials: M
authors.lastname: Brundage
authors.affiliation: European Organization for Research and Treatment of Cancer, Brussel, Belgium.
authors.forename: Andrew
authors.initials: A
authors.lastname: Bottomley
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000523:psychology* / Q000556:secondary*; D005060:Europe; D005260:Female; D017408:Guidelines as Topic; D006305:Health Status Indicators; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000523:psychology; D010358:Patient Participation; D011594:Psychometrics; D011788:Quality of Life; D011795:Surveys and Questionnaires / Q000592:standards