title: Adult height in Turkish patients with Turner syndrome without growth hormone treatment.
abstract: Spontaneous adult height (AH) in Turner syndrome (TS) varies among populations. Population-specific AH data is essential to assess the efficacy of growth-promoting therapies in TS. A multicenter study was performed to establish AH of nongrowth hormone (GH)-treated Turkish patients with TS. One hundred ten patients with TS (diagnosed by karyotype) who reached AH (no growth in the previous year, or bone age > 15 years) without receiving GH treatment were included in the study. The average AH was found to be 141.6 +/- 7.0 cm at the age of 22.9 +/- 6.2 years, which is 18.4 cm below the population average and 16.4 cm below the patients' mid-parental heights. Bone age at start of estrogen replacement was 12.3 +/- 1.3 year. Karyotype distribution of the patients was 45X (43%), 45X/46XX (16%), 45X/46Xi (12%), 45XiXq (10%) and others (19%). When the patients were evaluated according to their karyotype as 45X and non-45X, no significant difference in AH was observed (142.4 +/- 6.9 cm vs 140.9 +/- 7.1 cm, respectively). Adult height of non-GH-treated Turkish TS patients obtained in this study was comparable to that of other Mediterranean populations, but shorter than that of Northern European patients. Karyotype does not seem to affect AH in TS.
authors.affiliation: Department of Pediatrics, Marmara University Faculty of Medicine, Istanbul, Turkey.
authors.forename: Abdullah
authors.initials: A
authors.lastname: Bereket
authors.forename: Serap
authors.initials: S
authors.lastname: Turan
authors.forename: Nursel
authors.initials: N
authors.lastname: Elçioğlu
authors.forename: Seniha
authors.initials: S
authors.lastname: Hacihanefioğlu
authors.forename: Nihal
authors.initials: N
authors.lastname: Memioğlu
authors.forename: Firdevs
authors.initials: F
authors.lastname: Baş
authors.forename: Rüveyde
authors.initials: R
authors.lastname: Bundak
authors.forename: Feyza
authors.initials: F
authors.lastname: Darendeliler
authors.forename: Hülya
authors.initials: H
authors.lastname: Günöz
authors.forename: Nurçin
authors.initials: N
authors.lastname: Saka
authors.forename: Oya
authors.initials: O
authors.lastname: Ercan
authors.forename: Ilknur
authors.initials: I
authors.lastname: Arslanoğlu
authors.forename: Pinar
authors.initials: P
authors.lastname: Işgüven
authors.forename: Metin
authors.initials: M
authors.lastname: Yildiz
authors.forename: Sule
authors.initials: S
authors.lastname: Can
authors.forename: Ebru
authors.initials: E
authors.lastname: Ozerkan
authors.forename: Mahmut
authors.initials: M
authors.lastname: Coker
authors.forename: Sükran
authors.initials: S
authors.lastname: Darcan
authors.forename: Behzat
authors.initials: B
authors.lastname: Ozkan
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Orbak
authors.forename: Sitki
authors.initials: S
authors.lastname: Oztaş
authors.forename: Sükrü
authors.initials: S
authors.lastname: Palandüz
authors.forename: Ilhan
authors.initials: I
authors.lastname: Sezgin
authors.forename: Emre
authors.initials: E
authors.lastname: Atabek
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Erkul
authors.forename: Gürbüz
authors.initials: G
authors.lastname: Erdoğan
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D015995:Prevalence; D014421:Turkey / Q000453:epidemiology; D014424:Turner Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology*; D055815:Young Adult
chemical_list: D013006:Growth Hormone