title: Serologic detection of coccidioidomycosis antibodies in northeast Brazil.
abstract: Coccidioidomycosis is a systemic infection caused by Coccidioides spp. The disease is endemic in Brazil but its incidence is underreported as it is not a notifiable disease. This article presents the results of a serologic survey carried out with 229 volunteers in northeast Brazil by the immunodiffusion (ID) test with commercial Coccidioides spp. antigens. The commercial ID test detected 15 individuals without clinical diagnosis of the disease and two individuals in treatment for coccidioidomycosis. Regarding the epidemiological data, most of the positive individuals were male, between 18 and 65 years of age and were engaged in armadillo hunting. Three women who had never participated in armadillo hunts also displayed positive results for coccidioidal antibodies. Besides armadillo hunts, exposure to environmental dust in endemic areas may account for the serologic response detected in the study. The data from this study suggest the importance of performing epidemiological surveys for coccidioidomycosis in order to understand the prevalence of this disease in Brazil.
authors.affiliation: Specialized Medical Mycology Center, Federal University of Ceará, Fortaleza, Ceará, Brazil. ross@uece.br
authors.forename: Rossana de Aguiar
authors.initials: Rde A
authors.lastname: Cordeiro
authors.forename: Maria Auxiliadora Bezerra
authors.initials: MA
authors.lastname: Fechine
authors.forename: Raimunda Sâmia Nogueira
authors.initials: RS
authors.lastname: Brilhante
authors.forename: Marcos Fábio Gadelha
authors.initials: MF
authors.lastname: Rocha
authors.forename: Ana Karoline Freire
authors.initials: AK
authors.lastname: da Costa
authors.forename: Maria Aparecida Tiemi Dias
authors.initials: MA
authors.lastname: Nagao
authors.forename: Zoilo Pires
authors.initials: ZP
authors.lastname: de Camargo
authors.forename: José Júlio Costa
authors.initials: JJ
authors.lastname: Sidrim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000908:Antibodies, Fungal / Q000097:blood*; D000946:Antigens, Fungal / Q000276:immunology; D001938:Brazil / Q000453:epidemiology; D003045:Coccidioides / Q000276:immunology*; D003047:Coccidioidomycosis / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D005779:Immunodiffusion / Q000379:methods; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
chemical_list: D000908:Antibodies, Fungal; D000946:Antigens, Fungal