Metabolic syndrome-From human organ disease to laminar failure in equids.
Obesity, insulin resistance, hyperinsulinemia and hypertriglyceridemia are components of an equine metabolic syndrome phenotype associated with increased laminitis risk in horses. Links between these conditions and laminitis must still be elucidated, but human medicine provides candidate mechanisms for future study, including inflammation associated with obesity, vascular compromise induced by insulin resistance, and endothelial dysfunction. Just as metabolic syndrome has been linked to cardiovascular disease in humans, studies are now required to determine the exact mechanisms responsible for the increased predisposition to laminitis observed in horses with equine metabolic syndrome.
Geor
Raymond
R
Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States. geor@cvm.msu.edu
Frank
Nicholas
N
D000818:Animals; D005534:Foot Diseases / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D006724:Hoof and Claw; D006734:Horse Diseases / Q000209:etiology / Q000473:pathology*; D006736:Horses; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D024821:Metabolic Syndrome / Q000150:complications / Q000473:pathology / Q000662:veterinary*