Structure of full-length PPARgamma-RXRalpha: a snapshot of a functional complex?
The first crystal structure of a full-length nuclear receptor complex on DNA reveals an interdomain contact between the ligand- and DNA-binding domains of subunits and illuminates the role of the 5' extension of the binding site in polarity of positioning. These findings have possible functional implications.
Moras
Dino
D
Laboraratoire de Biologie et de Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, Illkircho 67400 Cedex, France. moras@igbmc.fr
D018360:Crystallography, X-Ray; D047495:PPAR gamma / Q000737:chemistry*; D055503:Protein Multimerization; D017434:Protein Structure, Tertiary; D047490:Retinoid X Receptor alpha / Q000737:chemistry*; D013329:Structure-Activity Relationship
D047495:PPAR gamma; D047490:Retinoid X Receptor alpha