title: Intradermal vaccination of pigs against FMD with 1/10 dose results in comparable vaccine efficacy as intramuscular vaccination with a full dose.
abstract: The aim of this study was to investigate whether intradermal (ID) vaccination against foot-and-mouth disease (FMD) is suitable as an alternative for the usually used intramuscular (IM) route. We compared vaccine efficacy in groups of pigs in which vaccine administration differed with respect to antigen payload of the vaccine, administrated volume and administration route. When compared with pigs that were IM vaccinated with a full dose vaccine with a standard antigen payload, pigs vaccinated ID with 1/10 dose of the same vaccine were equally protected against clinical disease and subclinical virus shedding. The ID vaccinated pigs were protected against virus shedding at a significant lower VN-titre as compared to IM vaccinated pigs, suggesting that immune responses other than neutralising antibodies also contributed to protection. We conclude that the ID route might be a good alternative for IM application, as ID application might induce a very efficient immunological response against FMD and, moreover, because the dose required by the ID route is lower compared to the IM route, ID application may reduce the production costs per dose of FMD vaccine markedly.
authors.affiliation: Central Veterinary Institute of Wageningen UR (CVI), P.O. Box 65, 8200 AB Lelystad, The Netherlands. phaedra.eble@wur.nl
authors.forename: P L
authors.initials: PL
authors.lastname: Eblé
authors.forename: K
authors.initials: K
authors.lastname: Weerdmeester
authors.forename: F
authors.initials: F
authors.lastname: van Hemert-Kluitenberg
authors.forename: A
authors.initials: A
authors.lastname: Dekker
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D005536:Foot-and-Mouth Disease / Q000517:prevention & control*; D029544:Foot-and-Mouth Disease Virus / Q000276:immunology*; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D009500:Neutralization Tests; D012720:Severity of Illness Index; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D017201:Virus Shedding / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D014765:Viral Vaccines