Murine models for evaluating the allergenicity of novel proteins and foods.
Genetically modified crops convey many benefits to world population. However, a rigorous safety assessment procedure, including an evaluation of the allergenic potential, is fundamental before their release into the food chain. As an integral part of the safety assessment process, regulatory authorities worldwide strongly recommend the use of tests that can predict the allergenic potential of the novel proteins. All guidance documents are based on an array of tests that have been proposed in 2003 by the Codex Alimentarius. Although the animal model is not a requirement of the Codex Alimentarius weight of evidence approach, allergenic hazard of novel proteins could only be evaluated by an in vivo model that can potentially identify and distinguish commonly allergenic proteins from rarely allergenic proteins. Therefore, food allergy experts encourage its development. During the 2007 International Life Science Institute (ILSI) workshop (Nice, France), worldwide experts shared their latest research results on rodent models to evaluate the allergenic potential of proteins and foods. This review presents the most promising rodent models for assessing food protein allergenicity that were evaluated during this ILSI workshop.
Aldemir
Hatice
H
University of Paris Sud XI, Faculty of Pharmacy, Châtenay Malabry, France. Aldemir.HA@gmail.com
Bars
Rémi
R
Herouet-Guicheney
Corinne
C
D000485:Allergens / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000096:biosynthesis; D004797:Enzyme-Linked Immunosorbent Assay; D005512:Food Hypersensitivity / Q000209:etiology*; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D023421:Models, Animal; D011506:Proteins / Q000276:immunology*; D018570:Risk Assessment
D000485:Allergens; D016207:Cytokines; D007074:Immunoglobulin G; D011506:Proteins; D007073:Immunoglobulin E