A haplotype of the CYP4F2 gene associated with myocardial infarction in Japanese men.
This study assessed associations between the CYP4F2 gene and myocardial infarction (MI), using a haplotype-based case-control study of 234 MI patients and 248 controls genotyped for 5 single-nucleotide polymorphisms (rs3093105, rs3093135, rs1558139, rs2108622, rs3093200). For men, G allele frequency of rs2108622 and frequency of the T-C-G haplotype were significantly higher, and frequency of the T-C-A haplotype was significantly lower for MI patients than for controls (P=0.006, P=0.001 and P=0.002, respectively).
Fu
Zhenyan
Z
Department of Advanced Medical Science, Division of Molecular Diagnostics, Nihon University School of Medicine, Tokyo, Japan.
Nakayama
Tomohiro
T
Sato
Naoyuki
N
Izumi
Yoichi
Y
Kasamaki
Yuji
Y
Shindo
Atsushi
A
Ohta
Masakatsu
M
Soma
Masayoshi
M
Aoi
Noriko
N
Sato
Mikano
M
Ozawa
Yukio
Y
Ma
Yitong
Y
Matsumoto
Koichi
K
Doba
Nobutaka
N
Hinohara
Shigeaki
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000072470:Cytochrome P450 Family 4; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012737:Sex Factors
D003577:Cytochrome P-450 Enzyme System; D000072470:Cytochrome P450 Family 4; C117480:CYP4F2 protein, human