Pregnancy and the kidney.
Nephrologists are frequently called on to diagnose and treat renal disorders in pregnant women. In this review, we update recent literature pertinent to pregnancy and renal disease. We initially begin by describing the application of common clinical estimators of GFR and proteinuria in pregnancy and then summarize recent studies regarding pregnancy in women with chronic kidney disease and the latest information on the use of common renal medications in pregnancy. In the final section, we describe advances in our understanding of the pathophysiology of preeclampsia and the potential clinical implications of these discoveries for screening, prevention, and treatment of preeclampsia.
Maynard
Sharon E
SE
George Washington University Medical Faculty Associates, 2150 Pennsylvania Avenue NW, Washington, DC 20037, USA. sharonmaynard@gmail.com
Thadhani
Ravi
R
D000818:Animals; D002908:Chronic Disease; D005260:Female; D037161:Galectins / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007674:Kidney Diseases / Q000175:diagnosis*; D016030:Kidney Transplantation; D011225:Pre-Eclampsia / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011257:Pregnancy Proteins / Q000097:blood; D011507:Proteinuria / Q000175:diagnosis; D044140:Receptor, Angiotensin, Type 1 / Q000502:physiology; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology
D037161:Galectins; D007166:Immunosuppressive Agents; C038195:LGALS13 protein, human; D011257:Pregnancy Proteins; D044140:Receptor, Angiotensin, Type 1