Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb.
Four new dimeric sesquiterpene lactones japonicones A-D (1-4), comprised by eudesmane and guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1-4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435.
Qin
Jiang Jiang
JJ
School of Pharmacy, Shanghai Jiao Tong University, MinHang DongChuan Rd800, Shanghai 200240, PR China.
Jin
Hui Zi
HZ
Fu
Jian Jun
JJ
Hu
Xiao Jia
XJ
Wang
Yan
Y
Yan
Shi Kai
SK
Zhang
Wei Dong
WD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray / Q000379:methods; D019281:Dimerization; D006801:Humans; D038143:Inula / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry*; D013237:Stereoisomerism; D013778:Tetrazolium Salts / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D045789:Sesquiterpenes, Guaiane; D013778:Tetrazolium Salts; D013844:Thiazoles; C585467:japonicone A; C022616:thiazolyl blue