[Influence of canthaxanthin on D-galactose induced osseous changes of rat].
OBJECTIVE
To study the influence of canthaxanthin on D-galactose induced osseous changes of rat.


METHODS
Forty-five six-week-old Wistar male rats were randomly divided into model group, canthaxanthin group and young control group. In addition, 15 sixteen-month-old Wistar male rats were used as old control group. Model group and canthaxanthin group were given injections of D-galactose for 5 months (20 mg/kg/once per-day) to cause aging of rat. Then routine osseous parameters were tested and compared among the 4 groups.


RESULTS
Compared with young control group, the BMD, parameters of structural mechanics and biomechanics, bone calcium, manganese, magnesium and the content of hydroxyproline in the model group decreased significantly (P < 0.01), however, the content of bone phosphorus, the activity of bone and serum ALP increased significantly (P < 0.01). Those changes of the model group were the same as the old control group,but the changes in the canthaxanthin group significantly differed with the model group (P < 0.01).


CONCLUSIONS
The high does of D-galactose intake can cause aging and osteoporosis at the same time in rat, but canthaxanthin can prevent and inhibit D-galactose induced osseous changes.
Pei
Ling-peng
LP
The Research Institution of Orthopaedics, China Academy of Chinese Medicine Science, Beijing 100700, Chinai.
Hui
Bo-di
BD
Dong
Fu-hui
FH
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000737:chemistry / Q000187:drug effects*; D002118:Calcium / Q000032:analysis; D016644:Canthaxanthin / Q000494:pharmacology*; D005690:Galactose / Q000633:toxicity*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood
D016644:Canthaxanthin; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D000469:Alkaline Phosphatase; D002118:Calcium; D005690:Galactose