G72/G30 (DAOA) and juvenile-onset mood disorders.
The chromosome 13q region has been linked to bipolar disorder in a number of genome scans as well as focused linkage studies. Previously we identified linkage to the 13q32 region in a genome scan of 146 affected sibling pair families from Hungary with juvenile-onset mood disorders. Within this region are the overlapping genes G72/G30, with G72 now officially named as D-amino-acid oxidase activator (DAOA). This locus has been associated with panic disorder, schizophrenia, and bipolar disorder. In this study, we tested for association to 11 markers in these genes and mood disorders in a sample of 646 nuclear families identified with a proband with onset of a mood disorder before 14.9 years of age. We identified evidence for association to three markers within the gene (rs2391191, rs3918341, rs1935062), two of which had been associated with bipolar disorder in previous studies. When corrected for the number of markers tested, the results were no longer significant, however the prior evidence for association of this gene in multiple studies points to this gene as a potential contributor to juvenile-onset mood disorders.
Gomez
Lissette
L
Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.
Wigg
Karen
K
Feng
Yu
Y
Kiss
Eniko
E
Kapornai
Krisztina
K
Tamás
Zsuzsa
Z
Mayer
László
L
Baji
Ildikó
I
Daróczi
Gabriella
G
Benák
István
I
Kothencné
Viola Osváth
VO
Dombovári
Edit
E
Kaczvinszk
Emília
E
Besnyo
Márta
M
Gádoros
Julia
J
King
Nicole
N
Székely
Judit
J
Kovacs
Maria
M
Vetró
Agnes
A
Kennedy
James L
JL
Barr
Cathy L
CL
D000293:Adolescent; D017668:Age of Onset; D002648:Child; D003605:D-Amino-Acid Oxidase / Q000235:genetics*; D005786:Gene Expression Regulation; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics; D015201:Meta-Analysis as Topic; D019964:Mood Disorders / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D003605:D-Amino-Acid Oxidase