Effect of UV irradiation and magnetic field on immunometabolic effects of antibiotics immobilized in cell carriers.
The effects of UV and magnetic radiation on the immunometabolic activity of ampicillin and cephazolin immobilized in erythrocytic and leukocytic carriers were studied in intact Wistar rats and animals infected with staphylococci. Erythrocytic and leukocytic carriers with antibiotics were obtained. Injection of free antibiotics stimulated the immunosuppressive, pro-oxidant, and hepatotoxic effects, associated with staphylococcal infection. Treatment with antibiotics in erythrocytic and leukocytic carriers stimulated (to different degrees) the activity of the immune system and stabilized the parameters of LPO, antioxidant defense, cytolysis, and cholestasis. Ultraviolet irradiation and magnetic field modified (to different measures) the immunometabolic effects of ampicillin and cephazolin, immobilized in erythrocytic and leukocytic carriers, in animals with staphylococcal infection.
Lazarev
A I
AI
Kursk State Medical University, Federal Agency for Public Health and Social Development, Russia.
Siplivyi
G V
GV
Kukureka
A V
AV
Siplivaya
L E
LE
D000667:Ampicillin / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D002437:Cefazolin / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use; D004574:Electromagnetic Fields; D004912:Erythrocytes / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy*; D014466:Ultraviolet Rays
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D002437:Cefazolin