Mechanisms of stimulation of granulocytopoiesis with neupogen in patients with breast cancer during chemotherapy.
The mechanisms of granulocytopoiesis stimulation with granulocytic CSF (neupogen), added to chemotherapy protocol (adriablastine+taxotere) in patients with stages III-IV breast cancer, were studied. The hemostimulatory effect of granulocytic CSF preparation is based on stimulation of proliferation and differentiation of granulomonocytopoisis precursor cell in the hemopoietic tissue, due to neupogen effects on hemopoietic elements and on the hemopoiesis-inducing microenvironment cells.
Khrichkova
T Yu
TY
Institute of Pharmacology and Institute of Oncology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Gol'dberg
V E
VE
Zhdanov
V V
VV
Matyash
M G
MG
Vysotckaya
V V
VV
Simolina
E I
EI
Shatalova
V A
VA
Popova
N O
NO
Miroshnichenko
L A
LA
Dygai
A M
AM
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D000077143:Docetaxel; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects* / Q000473:pathology / Q000502:physiology; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D011994:Recombinant Proteins; D043823:Taxoids / Q000008:administration & dosage; D016896:Treatment Outcome; D015854:Up-Regulation / Q000187:drug effects
D011994:Recombinant Proteins; D043823:Taxoids; D016179:Granulocyte Colony-Stimulating Factor; D000077143:Docetaxel; D004317:Doxorubicin; D000069585:Filgrastim