Effects of stent design and atherosclerotic plaque composition on arterial wall biomechanics.
OBJECTIVE
To examine the solid mechanical effects of varying stent design and atherosclerotic plaque stiffness on the biomechanical environment induced in a diseased artery wall model.


METHODS
Computational modeling techniques were employed to investigate the final radius of the lumen and artery wall stresses after stent implantation. Two stent designs were studied (one stiff and one less stiff). The stenotic artery was modeled as an axisymmetrical diseased vessel with a 20% stenosis by diameter. The material properties of the diseased tissue in the artery models varied. Atherosclerotic plaques half as stiff (0.5x), of equal stiffness (1.0x), or twice as stiff (2.0x) as the artery wall were investigated.


RESULTS
Final lumen radius was dependent on stent design, and the stiffer stent deformed the artery to an approximately 10% greater radius than the more compliant design. Alternatively, circumferential stress levels were dependent on both stent design and plaque material properties. Overall, the stiffer stent subjected the artery wall to much higher stress values than the more compliant design, with differences in peak values of 0.50, 0.31, and 0.09 MPa for the 2.0x, 1.0x, and 0.5x stiff plaques, respectively.


CONCLUSIONS
Evidence suggests that a judicious choice of stent design can minimize stress while maintaining a patent lumen in stenotic arteries. If confronted with a rigid, calcified plaque, stent design is more important, as design differences can impose dramatically different stress fields, while still providing arterial patency. Alternatively, stent design is not as much of an issue when treating a soft, lipid-laden plaque, as stress fields do not vary significantly among stent designs.
Timmins
Lucas H
LH
Department of Biomedical Engineering, Texas A&M University, College Station, TX 78843-3120, USA.
Meyer
Clark A
CA
Moreno
Michael R
MR
Moore
James E
JE
D001158:Arteries / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D050197:Atherosclerosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D001696:Biomechanical Phenomena; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation*; D002114:Calcinosis / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D003198:Computer Simulation; D003251:Constriction, Pathologic; D004548:Elasticity; D020342:Finite Element Analysis; D006801:Humans; D008422:Materials Testing; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D011475:Prosthesis Failure; D015607:Stents; D013314:Stress, Mechanical; D014654:Vascular Patency