title: Eyelid multiple cysts of the apocrine gland of Moll in Persian cats.
abstract: Feline eyelid hidrocystoma is a rarely reported disease of the apocrine glands of Moll that has been variably interpreted as proliferative/neoplastic lesion or retention cyst. The purpose of this paper was to investigate feline hidrocystoma pathogenesis by means of a histological and immunohistochemical study. Nine paraffin embedded biopsies of eyelid hidrocystoma were retrieved from our archives. Histological sections were immunostained with antibodies anti-cytoskeletal proteins and Ki67 antigen. All hidrocystomas were observed in Persian cats, seven males/two females, mean age 9.6 years. Histologically, single or multiple, variably sized cysts expanded eyelid dermis. Cyst was lined by cuboidal epithelium, occasionally raising in papillary structures. Immunostaining was consistent with apocrine gland epithelium (cytokeratin 8/18; 19 and 14 positive). Ki67 immunolabelled nuclei ranged from 5.3 to 20.83%. Although it was not possible to draw a definite conclusion concerning hidrocystoma aetiopathogenesis, the relatively high Ki67-proliferative index observed, suggested a proliferative nature of the lesion.
authors.affiliation: Section of Veterinary Pathology, Department of Veterinary Pathology, Hygiene and Public Health, University of Milan, via Celoria 10, 20133 Milan, Italy. chiara.giudice@unimi.it
authors.forename: Chiara
authors.initials: C
authors.lastname: Giudice
authors.forename: Maria C
authors.initials: MC
authors.lastname: Muscolo
authors.forename: Marco
authors.initials: M
authors.lastname: Rondena
authors.forename: Alberto
authors.initials: A
authors.lastname: Crotti
authors.forename: Valeria
authors.initials: V
authors.lastname: Grieco
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology* / Q000601:surgery; D002415:Cats; D003560:Cysts / Q000473:pathology / Q000662:veterinary*; D003937:Diagnosis, Differential; D005141:Eyelid Diseases / Q000473:pathology / Q000662:veterinary*; D005260:Female; D018251:Hidrocystoma / Q000662:veterinary; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D013544:Sweat Gland Neoplasms / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D019394:Ki-67 Antigen