Anxiety-like behaviors in mice lacking GIT2.
G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated GIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
Schmalzigaug
Robert
R
Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Rodriguiz
Ramona M
RM
Phillips
Lindsey E
LE
Davidson
Collin E
CE
Wetsel
William C
WC
Premont
Richard T
RT
D000818:Animals; D001008:Anxiety Disorders / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D020690:GTPase-Activating Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009483:Neuropsychological Tests; D010750:Phosphoproteins / Q000235:genetics*; D012727:Sex Characteristics; D015398:Signal Transduction / Q000235:genetics
D018797:Cell Cycle Proteins; D020690:GTPase-Activating Proteins; C120767:Git2 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D010750:Phosphoproteins