title: Severe asthma and its phenotype.
abstract: The phenotype of severe, or difficult, asthma is poorly understood, but recent studies have been informative. Factors associated with severe asthma include the presence of co-morbidities such as sinusitis, obesity and gastroesophageal reflux, poor adherence with prescribed medical regimens, and a severe underlying disease process. The worst long-term prognosis in severe asthma is associated with the presence of persistent airflow limitation and exacerbations. Individualization of therapy based on phenotype is highly recommended.
authors.affiliation: Asthma and Allergic Disease Programs, University of Pittsburgh/UPMC, Pittsburgh, PA, USA.
authors.forename: Sally E
authors.initials: SE
authors.lastname: Wenzel
mesh_terms: D001249:Asthma / Q000150:complications* / Q000235:genetics / Q000276:immunology / Q000628:therapy; D006801:Humans; D010641:Phenotype