Genetics of atrial fibrillation.
Recent studies of AF have identified mutations in a series of ion channels; however, these mutations appear to be relatively rare causes of AF. A genome-wide association study has identified novel variants on chromosome 4 associated with AF, although the mechanism of action for these variants remains unknown. Ultimately, a greater understanding of the genetics of AF should yield insights into novel pathways, therapeutic targets, and diagnostic testing for this common arrhythmia.
Lubitz
Steven A
SA
Cardiovascular Institute, Mount Sinai School of Medicine, New York, NY 10029, USA.
Yi
B Alexander
BA
Ellinor
Patrick T
PT
D001281:Atrial Fibrillation / Q000235:genetics*; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007473:Ion Channels / Q000235:genetics; D009154:Mutation
D007473:Ion Channels; D004247:DNA