[Hemorrhagic vesicle-bullous lesions in Henoch-Schönlein purpura and review of literature].
BACKGROUND
The characteristic feature of Henoch-Schönlein purpura (HSP) is palpable purpura, however hemorrhagic vesicles and blisters have been rarely reported.


METHODS
From January 1983 to December 2007, 5079 patients were followed in our Pediatric Rheumatology Unit, 232 (4.6%) of them with the diagnosis of HSP. Three female patients (1.3%) presented hemorrhagic vesicles and bullous lesions associated with palpable purpura. In one case the lesions were severe and widespread, and in another they preceded the typical purpuric lesions. In both cases, skin biopsy disclosed leukocytoclastic vasculitis with IgA and C3 deposits. Two patients healed with residual lesions: ulcers in one case and skin hyperpigmentation in two of them.


CONCLUSIONS
Hemorrhagic vesicle-bullous lesions are rare in HSP. This manifestation may represent a more severe and prolonged disease course with scars or may precede typical skin lesions.
Júnior
Carlos Rabelo
CR
Programa de Ciências Médicas da Faculdade de Medicina da Universidade de São Paulo (FMUSP), SP, Brazil.
Yamaguti
Renata
R
Ribeiro
Aline Miranda
AM
Melo
Bárbara Araújo
BA
Campos
Lúcia Arruda
LA
Silva
Clovis Almeida
CA
D001768:Blister / Q000209:etiology* / Q000473:pathology; D002648:Child; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications*