Evaluation of ultrafast 2D NMR for quantitative analysis.
Recent ultrafast methods make it possible to obtain two-dimensional (2D) nuclear magnetic resonance (NMR) spectra in a fraction of a second. This paper presents the first evaluation of ultrafast 2D NMR for quantitative analysis. On the basis of optimized conditions presented in recent studies, two homonuclear ultrafast techniques, J-resolved spectroscopy and TOCSY, are evaluated on model mixtures in terms of repeatability, long time stability, and linearity. The results are compared to conventional 1D (1)H NMR spectroscopy. Repeatabilities better than 1% for ultrafast J-resolved spectra and better than 7% for TOCSY spectra are obtained. The long-term stability is better than 4% for J-resolved spectroscopy and between 2% and 11% for TOCSY. Moreover, both methods are characterized by excellent linearities. This new analytical method opens important perspectives for fast, precise, and accurate quantitative analysis of complex mixtures and for the quantitative study of short time scale phenomena.
Giraudeau
Patrick
P
Universite de Nantes, CNRS, CEISAM UMR 6230, B. P. 92208, 2 Rue de la Houssiniere, F-44322 Nantes Cedex 03, France. patrick.giraudeau@univ-nantes.fr
Remaud
Gérald S
GS
Akoka
Serge
S
D000431:Ethanol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D000432:Methanol / Q000737:chemistry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods
D000431:Ethanol; D000432:Methanol