[Genetic polymorphism of growth hormone gene in adolescent idiopathic scoliosis].
OBJECTIVE
To investigate whether the growth hormone gene (GH) promotor polymorphism (rs2854184) is associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).


METHODS
Two hundred and sixty-five AIS patients and 193 normal controls were recruited. The maximum Cobb angles were recorded in AIS patients. PCR-RFLP was used for the genotyping.


RESULTS
The genotype frequency distribution were AA 38.3%, AT 50.3%, TT 11.4% in AIS patients and AA 39.6%, AT 50.2%, 10.1% TT in controls for the promotor polymorphism rs2854184 in GH gene. It was comparable between AIS and normal control. The allele frequency distribution was also comparable between AIS and normal control. It was 63.5% for allele A, 36.5% for allele T in AIS patients and 64.7% for allele A, 35.3% for allele T in normal control. The mean maximum Cobb angle in AIS patients with AA, AT, TT genotypes were 33.8 degrees +/- 10.0 degrees, 36.4 degrees +/- 15.0 degrees, 34.5 degrees +/- 9.1 degrees, respectively, it was similar with each other.


CONCLUSIONS
The GH gene promoter polymorphism is neither associated with the occurrence nor the curve severity of AIS.
Qiu
Xu-sheng
XS
Department of Spinal Surgery, the Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Deng
Liang-sheng
LS
Yang
Xiao-en
XE
Zheng
Zhen-yao
ZY
Qiu
Yong
Y
D000293:Adolescent; D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D019382:Human Growth Hormone / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D012600:Scoliosis / Q000235:genetics*
D019382:Human Growth Hormone