Oral mucosal cell response to Candida albicans in transgenic mice expressing HIV-1.
Controlled studies on the immunopathogenesis of mucosal candidiasis in HIV infection have been hampered by the lack of a relevant animal model. We have previously reported that oral Candida infection in CD4C/HIV transgenic mice expressing gene products of HIV-1 in immune cells and developing an AIDS-like disease closely mimics oropharyngeal candidiasis in human HIV infection. The role of defective dendritic cells and CD4+ T cells in impaired induction of protective immunity and in the phenotype of chronic oral carriage of C. albicans can now be investigated under controlled conditions in these transgenic mice.
de Repentigny
Louis
L
Department of Microbiology and Immunology, Sainte-Justine Hospital and University of Montreal, Montreal, Quebec, Canada.
Lewandowski
Daniel
D
Aumont
Francine
F
Hanna
Zaher
Z
Jolicoeur
Paul
P
D017088:AIDS-Related Opportunistic Infections / Q000209:etiology* / Q000276:immunology; D000818:Animals; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000209:etiology* / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D017931:DNA Primers / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009061:Mouth Mucosa / Q000276:immunology* / Q000382:microbiology*
D016207:Cytokines; D017931:DNA Primers