[Peripheral dendritic cell subpopulation changes in patients with coronary artery disease].
OBJECTIVE
To compare the peripheral dendritic cell subpopulation changes in patients with or without coronary artery disease.


METHODS
A total of 60 patients with angiographic documented coronary artery disease (CAD) were recruited in this study, including 20 cases with acute myocardial infarction (AMI group), 20 cases with unstable angina(UA group) and 20 patients with stable angina (SA group). Eleven patients with chest pain and without coronary stenosis served as chest pain control (CPS group). Ten cases without heart diseases served as normal control (Normal control group). Numbers of peripheral myeloid dendritic cell (mDC) and plasmacytoid dendritic cell (pDC) precursors were determined by FACS.


RESULTS
The proportions of mDC precursors were significantly lower in UA group and AMI group (4.7% +/- 2.6%, 5.0% +/- 2.7%) than that in SA, CPS and control groups (11.0% +/- 6.4%, 12.0% +/- 3.9%, 12.3% +/- 3.3%, respectively, all P < 0.001). pDC numbers were similar among groups.


CONCLUSIONS
Reduced circulating mDC subsets in patients with unstable angina and AMI might suggest enhanced mDC recruitment to vulnerable plaques in these patients.
Fu
Qiang
Q
Department of Cardiology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China.
Li
Zhi-Liang
ZL
Lei
Xiao
X
Fu
Xiao-Hua
XH
Yan
Quan-Neng
QN
Liu
Ying-Feng
YF
D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000276:immunology; D016022:Case-Control Studies; D002452:Cell Count; D003324:Coronary Artery Disease / Q000097:blood / Q000276:immunology*; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000276:immunology