Synthesis of oxindoles by tandem Heck-reduction-cyclization (HRC) from a single bifunctional, in situ generated Pd/C catalyst.
A tandem sequence involving palladium-catalyzed sequential Heck-reduction-cyclization transformations in mild conditions has been developed for the synthesis of oxindoles. The protocol involves inexpensive reagents and does not require any additives such as base or ligands.
Felpin
François-Xavier
FX
Universite de Bordeaux, CNRS, Institut des Sciences Moleculaires, 351 Cours de la Liberation, 33405 Talence Cedex, France. fx.felpin@ism.u-bordeaux1.fr
Ibarguren
Oier
O
Nassar-Hardy
Luma
L
Fouquet
Eric
E
D000179:Acrylates / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D000078183:Oxindoles; D010165:Palladium / Q000737:chemistry
D000179:Acrylates; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D010165:Palladium