title: Protection against Asiatic Taenia solium induced by a recombinant 45W-4B protein.
abstract: Taenia solium is a great threat not only to human health but also to the pig-raising industry. Oncospheral stage-specific 45W proteins are good candidates for the development of anticysticercosis vaccines. In this study, a recombinant 45W-4B protein was highly produced and used for vaccination. Two animal trials resulted in a significant reduction in parasite burden induced by the definite protein against Asiatic T. solium, up to 97.0% and 98.4%, respectively. These provide informative results for the development of effective 45W-4B vaccines against cysticercosis caused by both Chinese and Mexican T. solium isolates and even by other isolates.
authors.affiliation: Key Laboratory of Zoonoses of CAAS, Key Laboratory of Veterinary Parasitology of Gansu Province, State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, CAAS, Lanzhou, Gansu, China.
authors.forename: Xuenong
authors.initials: X
authors.lastname: Luo
authors.forename: Yadong
authors.initials: Y
authors.lastname: Zheng
authors.forename: Junling
authors.initials: J
authors.lastname: Hou
authors.forename: Shaohua
authors.initials: S
authors.lastname: Zhang
authors.forename: Xuepeng
authors.initials: X
authors.lastname: Cai
mesh_terms: D000818:Animals; D000947:Antigens, Helminth / Q000276:immunology*; D002681:China; D003551:Cysticercosis / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000276:immunology / Q000517:prevention & control*; D041201:Taenia solium / Q000276:immunology*
chemical_list: D000947:Antigens, Helminth