title: Physiological responses to graded acute normobaric hypoxia using an intermittent walking protocol.
abstract: OBJECTIVE
  The study aimed to examine the physiological responses to acute normobaric hypoxia during an intermittent walking protocol.
  
  
  METHODS
  Twelve active healthy male participants completed a 125-minute test that involved rest and walking (50% VO(2max)) during normoxic (20.93%O(2)) and 2 hypoxic conditions (14%O(2) and 12%O(2)). A range of physiological markers were measured throughout the test. Lake Louise Questionnaire scores and Environmental Symptoms Questionnaire cerebral scores were used as a measurement of acute mountain sickness symptoms.
  
  
  RESULTS
  Oxygen saturation, thermal sensation scale, heart rate, perceived thirst, core temperature, rating of perceived exertion, feeling state, and Deltabody mass all positively correlated with the highest Lake Louise Questionnaire and Environmental Symptoms Questionnaire cerebral scores (P < .05) and were significantly different between the 3 conditions during the exercise phases.
  
  
  CONCLUSIONS
  A range of physiological markers are associated with symptoms of acute mountain sickness following brief periods of hypoxic exposure.
authors.affiliation: University of Brighton, Chelsea School Research Centre, Eastbourne, United Kingdom. a.j.richardson@brighton.ac.uk
authors.forename: Alan
authors.initials: A
authors.lastname: Richardson
authors.forename: Rosie
authors.initials: R
authors.lastname: Twomey
authors.forename: Peter
authors.initials: P
authors.lastname: Watt
authors.forename: Neil
authors.initials: N
authors.lastname: Maxwell
mesh_terms: D000208:Acute Disease; D000328:Adult; D000532:Altitude Sickness / Q000175:diagnosis* / Q000453:epidemiology; D015415:Biomarkers; D002245:Carbon Dioxide / Q000494:pharmacology; D018592:Cross-Over Studies; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology*; D012146:Rest / Q000502:physiology*; D011795:Surveys and Questionnaires; D013997:Time Factors; D016138:Walking / Q000502:physiology*
chemical_list: D015415:Biomarkers; D002245:Carbon Dioxide