Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis.
The purpose of the study was to investigate whether dietary intake of curcumin can inhibit the onset and progression of seizures and their associated pathophysiology in experimental FeCl(3)-induced epileptogenesis. Curcumin was considered for this study because it can cross the blood-brain barrier and bind redox-active metal ions. It is also well known for its antioxidative, anticancer, and anti-inflammatory properties. In the present study, seizures were induced by intracortical injection of FeCl(3) into young rats. Synchronized video/EEG recordings were obtained to diagnose the progression of seizures. Short-term treatment with a curcumin-supplemented diet (1500 pp mw/w) significantly inhibited the onset of grade III and IV seizures in rats with iron-induced epilepsy. The lower dose of curcumin (500 ppm) was not effective in inhibiting grade III seizures, but retarded the onset and progression of generalized seizures. The seizure-suppressing potential of curcumin is explained by the observed biochemical, behavioral, and ultrastructural results. Our results indicate that curcumin significantly prevents generalization of electroclinical seizure activity as well as the pathogenesis associated with iron-induced epileptogenesis.
Jyoti
Amar
A
Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Sethi
Pallavi
P
Sharma
Deepak
D
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002540:Cerebral Cortex / Q000473:pathology / Q000648:ultrastructure; D003474:Curcumin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D018450:Disease Progression; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D005106:Exploratory Behavior / Q000187:drug effects; D005290:Ferric Compounds; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008560:Membrane Fluidity / Q000187:drug effects; D046529:Microscopy, Electron, Transmission / Q000379:methods; D050050:Protein Carbonylation / Q000187:drug effects / Q000502:physiology; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014743:Videotape Recording / Q000379:methods
D000975:Antioxidants; D005290:Ferric Compounds; D017392:Thiobarbituric Acid Reactive Substances; D011493:Protein Kinase C; D000254:Sodium-Potassium-Exchanging ATPase; D003474:Curcumin