Neuroprotective activity of mexidole and 3-hydroxypyridine acetylcysteinate against the background of cerebral ischemia in the complex of experimental diabetes mellitus and exogenous hypercholesterolemia.
We studied the interaction of mexidol and 3-hydroxypyridine acetylcysteinate on the model of experimental ischemic stroke in rats. The preparations were effective in a dose 50 mg/kg (10-day treatment): they reduced the incidence of neurological disturbances (pareses, sensitivity disturbances) and improved antioxidant defense of the plasma.
Inchina
V I
VI
N. P. Ogarev Mordovian State University.
Bukina
S J
SJ
D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D005260:Female; D006937:Hypercholesterolemia / Q000150:complications*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D016896:Treatment Outcome
D018696:Neuroprotective Agents; D010847:Picolines; C070020:emoxypine succinate; D000111:Acetylcysteine