Carbapenem resistance among Pseudomonas aeruginosa strains from India: evidence for nationwide endemicity of multiple metallo-beta-lactamase clones (VIM-2, -5, -6, and -11 and the newly characterized VIM-18).
Among 57 metallo-beta-lactamase (MbetaL)-producing Pseudomonas spp. detected in India during 2006, five bla(VIM) genes were found, including a newly characterized bla(VIM) gene. Pseudomonas aeruginosa strains were clustered in 33 ribotypes with clones found in multiple hospitals. Several types of bla(VIM-2)-carrying integrons were detected. The newly characterized variant VIM-18 showed a 4-amino-acid deletion compared to other VIM variants. In this study, we show that VIM-producing Pseudomonas spp. were highly prevalent in India with a great diversity of bla(VIM) types and MbetaL-carrying integrons.
Castanheira
Mariana
M
JMI Laboratories, North Liberty, Iowa 52317, USA. mariana-castanheira@jmilabs.com
Bell
Jan M
JM
Turnidge
John D
JD
Mathai
Dillip
D
Jones
Ronald N
RN
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D015780:Carbapenems / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D007194:India / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D015995:Prevalence; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D021521:Ribotyping; D001618:beta-Lactamases / Q000145:classification* / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases; C540661:beta-lactamase VIM-11, Pseudomonas aeruginosa; C540662:beta-lactamase VIM-18, Pseudomonas aeruginosa; C490697:beta-lactamase VIM-5, Pseudomonas aeruginosa; C534603:beta-lactmase VIM-6, Pseudomonas aeruginosa