Submucosal saline-epinephrine injection in colon polypectomy: appropriate indication.
OBJECTIVE
Opinions vary among endoscopists concerning the indications for submucosal saline-epinephrine injection for the prevention of postpolypectomy complications after colonic snare polypectomy. This study was performed to determine the appropriate indications for submucosal saline-epinephrine injection.


METHODS
Clinical characteristics and complications (hemorrhage and perforation) in polypectomies were retrospectively evaluated. Postpolypectomy complications were analyzed in terms of demographic characteristics (age, gender), polyp characteristics (size, configuration, location, and histopathology), and the administration of submucosal saline-epinephrine injection.


RESULTS
Total 1039 polypectomies were performed in 563 patients (age 59.8 +/- 10.1 years), and submucosal saline-epinephrine injection was performed in 679 polypectomies. Twenty seven episodes (2.6%) of hemorrhage and 3 cases (0.2%) of perforation occurred. Malignant adenoma, a rectal polyp, and procedure without submucosal saline-epinephrine injection increased the risk of hemorrhage with odds ratios of 10.48, 4.71, and 3.44, respectively. Furthermore, submucosal saline-epinephrine injection significantly reduced the risk of hemorrhage in sessile polyps and those > 8 mm in size and with odds ratio of 16.41 regardless of location or histopathology. The occurrence of postpolypectomy perforation was not associated with any clinical characteristics and method.


CONCLUSIONS
Submucosal saline-epinephrine injection should be performed for sessile polyps and those > 8 mm in size, and might be performed optionally in other cases to prevent postpolypectomy hemorrhage.
Lee
Sang Hyub
SH
Department of Internal Medicine, Seoul National University Bundang Hospital.
Lee
Kyoung Soo
KS
Park
Young Soo
YS
Hwang
Jin-Hyeok
JH
Kim
Jin-Wook
JW
Jung
Sook-Hyang
SH
Kim
Nayoung
N
Lee
Dong Ho
DH
Kim
Sang Gyun
SG
Kim
Joo Sung
JS
Jung
Hyun Chae
HC
Yoon
Yong Bum
YB
Song
In Sung
IS
D000328:Adult; D000368:Aged; D003111:Colonic Polyps / Q000601:surgery*; D004837:Epinephrine / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D012965:Sodium Chloride / Q000008:administration & dosage*
D012965:Sodium Chloride; D004837:Epinephrine