Dual and beneficial roles of macrophages during skeletal muscle regeneration.
Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair.
Chazaud
Bénédicte
B
Institut COCHIN INSERM U567 CNRS UMR8104, Paris, France. benedicte.chazaud@inserm.fr
Brigitte
Madly
M
Yacoub-Youssef
Houda
H
Arnold
Ludovic
L
Gherardi
Romain
R
Sonnet
Corinne
C
Lafuste
Peggy
P
Chretien
Fabrice
F
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology; D018482:Muscle, Skeletal / Q000293:injuries / Q000502:physiology*; D032446:Myoblasts / Q000166:cytology; D010641:Phenotype; D012038:Regeneration