title: Integrative action of receptor mosaics: relevance of receptor topology and allosteric modulators.
abstract: After a definition of the receptor mosaic (RM, high order heteromer or homomer) concept, this study analyzes some relevant theoretical aspects related to receptor-receptor interactions (RRIs). In particular, the possible influence of the plasma membrane microdomain on RM integrative functions are discussed. Furthermore, a possible mathematical approach may identify the RM topologies [i.e., the spatial arrangements the receptors (tesserae of the mosaic) can assume within the RM assembly]. Finally, data are presented on homocysteine possible biasing action on the well-characterized heterodimer/receptor mosaic formed by adenosine A2A and dopamine D2 receptors. We discuss how these findings can lead to a new possible approach for developing drugs for the treatment of certain neuropsychiatric disorders.
authors.affiliation: Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS Lido, Venezia, Italy. agnatiluigi@tin.it
authors.forename: Agnati Luigi
authors.initials: AL
authors.lastname: Francesco
authors.forename: Guidolin
authors.initials: G
authors.lastname: Diego
authors.forename: Genedani
authors.initials: G
authors.lastname: Susanna
authors.forename: Leo
authors.initials: L
authors.lastname: Giuseppina
authors.forename: Woods S
authors.initials: WS
authors.lastname: Amina
authors.forename: Ferrè
authors.initials: F
authors.lastname: Sergi
authors.forename: Franco
authors.initials: F
authors.lastname: Rafael
authors.forename: Fuxe
authors.initials: F
authors.lastname: Kjell
mesh_terms: D000494:Allosteric Regulation; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D008962:Models, Theoretical; D020239:Receptor Cross-Talk / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D011956:Receptors, Cell Surface