[Progress in studies on effects of extracellular matrix in occurrence of proliferative vitreoretinopathy].
It has been found that various extracellular matrix (ECM) probably play an important role in the occurrence of proliferative vitreoretinopathy (PVR), including structural proteins, adhesive proteins, anti-adhesive proteins, matrix metalloproteinase (MMP), and tissue inhibitor of MMP (TIMP) Structural proteins, including collagen and elastic fiber family, are the major non-cellular components of PVR membrane, and could promote contraction of membrane. Adhesive proteins, including fibronectin, vitronectin, laminin, could promote adhesion between cells and ECM in PVR, they promote the attachment, migration and differentiation of retinal pigment epithelium (RPE). Anti-adhesive proteins, including thrombospondin-1, osteonectin, tenascin, could promote RPE migration and tissue remodeling of PVR, etc. MMPs and TIMPs could degrade some components of ECM, enhance permeability of blood vessel and promote neovascularization in PVR.
Wang
Liang-hai
LH
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University , Beijing 100730, China.
Li
Gen-lin
GL
D005109:Extracellular Matrix / Q000378:metabolism; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009389:Neovascularization, Pathologic; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism; D018630:Vitreoretinopathy, Proliferative
D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases