title: [Regulation of gene expression by long-chain fatty acids].
abstract: Besides of their role as important energy source and membrane component, long chain fatty acids also act as bioactive lipids involved in the regulation of such processes like cell proliferation and differentiation, protein acylation and sorting, inflammation, activation of enzymes and membrane receptors, and regulation of intracellular metabolism. One of the mechanisms by which fatty acids affect so many various biological processes is regulation of the gene transcription. Depending on the number of double bonds and carbon chain length, fatty acids may inhibit or activate expression of defined genes through either direct regulation of activity of nuclear receptors including PPAR, LXR and HNF-4 alpha or transcription factors mainly SREBP, ChREBP and NF kappa B; or indirectly, through physicochemical changes in membrane properties and activation of signal transduction pathways. In this paper we review the current understanding of the mechanisms by which fatty acids regulate gene expression and discuss their role in the pathogenesis of metabolic disorders.
authors.affiliation: Laboratory of Cell Signaling and Metabolic Disorders, Department of Biochemistry, Nencki Institute of Experimental Biology Polish Academy of Sciences, 3 Pasteura St., 02-093 Wasaw, Poland.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Jazurek
authors.forename: Paweł
authors.initials: P
authors.lastname: Dobrzyń
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Dobrzyń
mesh_terms: D002454:Cell Differentiation / Q000235:genetics; D002462:Cell Membrane / Q000378:metabolism; D049109:Cell Proliferation; D004789:Enzyme Activation / Q000235:genetics; D005227:Fatty Acids / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology*; D007249:Inflammation / Q000235:genetics; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics; D015398:Signal Transduction / Q000502:physiology
chemical_list: D005227:Fatty Acids; D018160:Receptors, Cytoplasmic and Nuclear