title: [Urgent hemostatic control with Confact F for ovarian bleeding complicated by an unknown type of von Willebrand disease].
abstract: Emergency surgery was performed on a 24-year-old female patient with an unknown type of von Willebrand disease (VWD). The patient suddenly developed lower abdominal pain and was transported to our hospital by ambulance. Based on the diagnosis of ovarian bleeding, emergency surgery was indicated. Ristocetin-cofactor activity (VWF: RCo) was between 7% and 14% by measurement with von Willebrand reagent (Dade Behring, Marburg, Germany). A laparoscopic partial resection of the left ovary was performed under administration of factor VIII/VWF concentrate, Confact F((R)) (Chemo-Sero-Therapeutic Research Institute, Kumamoto, Japan). During and after surgery, there was no abnormal bleeding. The results obtained by measurement by the reagent were similar to the levels of VWF: RCo obtained by the fixed platelet agglutination method. The reagent was useful for diagnosing and monitoring the VWF: RCo level to control bleeding in VWD.
authors.affiliation: Department of Laboratory Medicine, Tokyo Medical University, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kagawa
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Oishi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Kawata
authors.forename: Atsuya
authors.initials: A
authors.lastname: Fujito
authors.forename: Keiichi
authors.initials: K
authors.lastname: Isaka
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Fukutake
mesh_terms: D015415:Biomarkers / Q000097:blood; D005169:Factor VIII / Q000008:administration & dosage*; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000628:therapy*; D006490:Hemostatics / Q000008:administration & dosage*; D006801:Humans; D010535:Laparoscopy; D010049:Ovarian Diseases / Q000209:etiology* / Q000628:therapy*; D010052:Ovariectomy; D011933:Reagent Kits, Diagnostic; D055815:Young Adult; D014842:von Willebrand Diseases / Q000150:complications*; D014841:von Willebrand Factor / Q000008:administration & dosage* / Q000032:analysis
chemical_list: D015415:Biomarkers; D006490:Hemostatics; D011933:Reagent Kits, Diagnostic; D014841:von Willebrand Factor; D005169:Factor VIII