Alternative splicing of CD45: the tip of the iceberg.
Mechanisms underlying the regulated splicing of CD45 RNA have been long-standing puzzles. In this issue of Immunity, Wu et al. (2008) identify hnRNPLL as a critical regulator of both signal-induced exon skipping in CD45 and global alternative-transcript expression in memory T cells.
Zikherman
Julie
J
Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.
Weiss
Arthur
A
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D005091:Exons / Q000235:genetics*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics*; D051379:Mice; D020033:Protein Isoforms / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism*
D020033:Protein Isoforms; D017493:Leukocyte Common Antigens