[Clinicopathologic characteristics and postoperative prognosis in colorectal cancer with peritoneal dissemination].
OBJECTIVE
To investigate the correlation between clinicopathologic factors and peritoneal dissemination in colorectal cancer, and the impact of surgery on the prognosis of patients with peritoneal dissemination.


METHODS
Based on the clinical database built in 1994, the clinicopathologic data and the result of follow-up of all colorectal cancer patients were analyzed retrospectively.


RESULTS
One hundred and fifty cases (7.40%) in all 2019 patients with primary colorectal cancer were found complicated with peritoneal dissemination. The clinicopathologic factors in patients with peritoneal dissemination were significantly correlated with tumor penetrating through serosa, lymph node metastasis, undifferentiated carcinoma, ascites, different pathological type, circumference of tumor, neoplastic intestinal obstruction, and Dukes staging. Peritoneal dissemination was associated with tumor penetrating through serosa, different pathological type on multivariate analysis. The 1-, 3-, 5-year survival rate of the patients with peritoneal dissemination were 70.4%, 38.1%, 30.2%; The 1-, 3-, 5-year survival rate of the patients undergoing radical resection were significant better than those in the cases undergoing palliative operation or palliative resection (P < 0.05).


CONCLUSIONS
Colorectal cancer complicated with peritoneal dissemination has poorer clinicopathologic characteristics. Those with local peritoneal dissemination has rather better prognosis than those with wide peritoneal dissemination. Radical resection of the disseminated tumor can improve the prognosis of the patients.
Song
Wu
W
Department of Gastrointestinopancreatic Surgery, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
He
Yu-long
YL
Cai
Shi-rong
SR
Zhang
Chang-hua
CH
Chen
Chuang-qi
CQ
Zhang
Xin-hua
XH
D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D009361:Neoplasm Invasiveness; D009366:Neoplasm Seeding; D010534:Peritoneal Neoplasms / Q000556:secondary*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis