[Increased autoantibody production against AT(1)-receptors and alpha(1)-adrenergic receptors in hypertensive patients].
OBJECTIVE
To observe autoantibodies production against AT(1)-receptors and alpha(1)-adrenergic receptors and association to risk factors, such as sex, age, family history, course of hypertension and other cardiovascular diseases in hypertensive patients.


METHODS
A total of 690 patients with essential hypertension admitted to our hospital were selected and autoantibodies against AT(1)-receptors and alpha(1)-adrenergic receptors were detected by ELISA. Multiple logistic regression analysis was performed based on obtained data.


RESULTS
Positive rates for antibody against AT(1)-receptors and alpha(1)-adrenergic receptors were 47.1% (325/690) and 36.4% (251/690) respectively in this group of patients. Duration of hypertension history was significantly longer in the antibody against AT(1)-receptors and alpha(1)-adrenergic receptors positive groups [(9.3 +/- 11.0) year, (9.9 +/- 11.1) year] compared to the negative groups [(7.3 +/- 9.3) year, (7.2 +/- 9.5) year, all P < 0.01]. The ratio of family history with hypertension was also significantly higher in antibody positive groups than negative ones (47.69% vs 39.18%, P < 0.01). Regression analysis demonstrated that 5 risk factors were related to positive production of autoantibody against AT(1)-receptors including female gender, age, family history, duration of hypertension history and diabetes. However, just age, family history, duration of hypertension history were main factors responsible to the production of autoantibody against alpha(1)-adrenergic receptors (all P < 0.05).


CONCLUSIONS
The environmental and genetic factors contributed to the autoantibody production in patients with essential hypertension.
Sun
Yan-Xiang
YX
Institute of Cardiology, Union Hospital, Tongji Medical College of Huazhong University of Science Technology, Wuhan 430022, China.
Zhu
Feng
F
Wang
Min
M
Li
Zheng-Zai
ZZ
Liao
Yu-Hua
YH
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D044140:Receptor, Angiotensin, Type 1 / Q000276:immunology*; D011942:Receptors, Adrenergic, alpha / Q000276:immunology*; D012307:Risk Factors
D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1; D011942:Receptors, Adrenergic, alpha