Mirror movements and involuntary homolateral limb synkinesis in a patient with probable Creutzfeldt-Jakob disease.
We report a 63-year-old man, who was diagnosed with probable Creutzfeldt-Jakob disease, manifested by rapid progressive cognitive decline, gait disturbance, right focal hand dystonia, myoclonus, mirror movements, and involuntary homolateral limb synkinesis during alternating limb movements. Although the exact pathophysiology for contralateral and homolateral limb synkinesis is not known, dysfunction of the secondary motor areas and dorsal premotor cortex by spongiform degeneration of gray matter may cause these abnormalities.
Park
In-Seok
IS
Department of Neurology, The Catholic University of Korea, Seoul, Republic of Korea.
Song
In-Uk
IU
Lee
Sang-Bong
SB
Lee
Kwang-Soo
KS
Kim
Hee-Tae
HT
Kim
Joong-Seok
JS
D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology*; D004421:Dystonia / Q000209:etiology / Q000503:physiopathology; D005121:Extremities / Q000503:physiopathology*; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000503:physiopathology*; D006225:Hand / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*; D009207:Myoclonus / Q000209:etiology / Q000503:physiopathology; D046608:Synkinesis / Q000209:etiology / Q000503:physiopathology*