title: [Long-term efficacy of sirolimus-eluting stents (Cypher) versus bare metal stents for patients with ST-segment elevation myocardial infarction].
abstract: OBJECTIVE
  To observe the safety and long-term efficacy of Cypher stent versus bare metal stents (BMS) in patients with STEMI.
  
  
  METHODS
  From Dec 2002 to Mar 2005, clinical and angiographic data of 407 consecutive patients with STEMI treated with Cypher stent (n = 131) or BMS (n = 276) were analyzed and followed up for a mean period of 28.7 +/- 11.7 months. Major adverse cardiac events (MACE): death, nonfatal reinfarction and target lesion revascularization (TLR) during follow up was compared between two groups.
  
  
  RESULTS
  Compared with the BMS group, diameter of vessels were significantly smaller (3.0mm vs. 3.2mm, P = 0.00), the incidence of MACE (6.1% vs. 12.7%, P = 0.04) and total mortality (1.5% vs. 6.9%, P = 0.02) were significantly lower in the Cypher group. The relative risk for MACE in Cypher group was 0.61 (P < 0.05), while there was no significant difference in the rate of stent thrombosis, rate of target lesion revascularization and restenosis.
  
  
  CONCLUSIONS
  Utilization of Cypher in the setting of primary PCI for STEMI was safe and improved the long-term clinical outcomes compared to BMS.
authors.affiliation: Heart Center, Beijing Chaoyang Hospital, Institute of Cardiovascular Diseases, Capital University of Medical Science, Beijing 100020, China.
authors.forename: Yong-gui
authors.initials: YG
authors.lastname: Ge
authors.forename: Da-peng
authors.initials: DP
authors.lastname: Zhang
authors.forename: Xin-chun
authors.initials: XC
authors.lastname: Yang
authors.forename: Le-feng
authors.initials: LF
authors.lastname: Wang
authors.forename: Hong-shi
authors.initials: HS
authors.lastname: Wang
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Zhu-hua
authors.initials: ZH
authors.lastname: Ni
authors.forename: Yong
authors.initials: Y
authors.lastname: Lian
authors.forename: Yong-li
authors.initials: YL
authors.lastname: Xue
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D054855:Drug-Eluting Stents; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D020123:Sirolimus / Q000008:administration & dosage; D015607:Stents; D016896:Treatment Outcome
chemical_list: D020123:Sirolimus