Stem cell sources for regenerative medicine.
Tissue-resident stem cells or primitive progenitors play an integral role in homeostasis of most organ systems. Recent developments in methodologies to isolate and culture embryonic and somatic stem cells have many new applications poised for clinical and preclinical trials, which will enable the potential of regenerative medicine to be realized. Here, we overview the current progress in therapeutic applications of various stem cells and discuss technical and social hurdles that must be overcome for their potential to be realized.
Riazi
Ali M
AM
Department of Chemical Engineering, University of Toronto, Toronto, Ontario, Canada.
Kwon
Sarah Y
SY
Stanford
William L
WL
D000818:Animals; D065150:Cellular Reprogramming; D019976:Cloning, Organism; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine / Q000379:methods*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*