title: Palladium-indolylphosphine-catalyzed Hiyama cross-coupling of aryl mesylates.
abstract: Aryl mesylates are found to be applicable as electrophiles in organosilicon-mediated coupling reactions. The catalyst system comprising 2 mol % of Pd(OAc)(2) and CM-phos supporting ligand is highly effective in catalyzing Hiyama cross-coupling of various aryl and heteroaryl mesylates. Interesting acid additive effects show that the presence of 0.25-0.50 equiv of acetic acid efficiently suppresses the mesylate decomposition and generally promotes the coupling product yields.
authors.affiliation: Open Laboratory of Chirotechnology of the Institute of Molecular Technology for Drug Discovery and Synthesis and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.forename: Hang Wai
authors.initials: HW
authors.lastname: Lee
authors.forename: Chak Po
authors.initials: CP
authors.lastname: Lau
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D008024:Ligands; D008698:Mesylates / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D008024:Ligands; D008698:Mesylates; D009942:Organometallic Compounds; D010165:Palladium; D002244:Carbon