title: Ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension for the topical treatment of ear infections: a review of the literature.
abstract: The objective of this article is to review the literature related to ciprofloxacin 0.3% and dexamethasone 0.1% sterile otic suspension. A systematic literature search utilizing Medline was conducted to identify peer-reviewed articles related to safety and efficacy. A total of 47 publications were identified and reviewed herein. The literature supports the use of antibiotic/antiiflammatory combination ear drops in the treatment of both acute otitis externa and acute otitis media in pediatric patients with tympanostomy tubes. Ciprofloxacin/dexamethasone has been demonstrated as safe and effective with regard to clinical cures and microbiological eradication of pathogens in either disease with low treatment failure rates. Additionally, the literature also provides clear evidence for the contribution of dexamethasone when added to ciprofloxacin for the topical treatment of ear infections.
authors.affiliation: Alcon Research Ltd, Fort Worth, TX, USA.
authors.forename: G Michael
authors.initials: GM
authors.lastname: Wall
authors.forename: David W
authors.initials: DW
authors.lastname: Stroman
authors.forename: Peter S
authors.initials: PS
authors.lastname: Roland
authors.forename: Joseph
authors.initials: J
authors.lastname: Dohar
mesh_terms: D000287:Administration, Topical; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D003907:Dexamethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D010032:Otitis Externa / Q000188:drug therapy*; D010033:Otitis Media / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D002939:Ciprofloxacin; D003907:Dexamethasone