title: Using population attributable risk to help target preventive interventions for adolescent depression.
abstract: Prevention of adolescent depression has become a public health priority in the United States (US) and in other developed economies. Population attributable risk (PAR) can provide an estimate of the incidence reduction that would occur if a particular factor were removed.
  
  
  OBJECTIVE
  To determine PAR of vulnerability factors for new-onset depressive episodes in United States (US) adolescents.
  
  
  METHODS
  National Longitudinal Study of Adolescent Health. The sample was comprised of nationally representative adolescents in grades 7-12, with mean age of 15.7 years.
  
  
  METHODS
  We determined PAR for identified vulnerability factors for US adolescents measured at baseline predicting a depressive episode at one-year follow-up. The baseline factors included socio-demographics and physical health factors; interpersonal relations; community and school factors and cognition/affect regulation.
  
  
  RESULTS
  Factors with significant PAR were identified from each major domain of adolescent life. With the exception of age, sexual activity had the highest PAR. Interpersonal relations, particularly those involving family members rather than peers, represented the most important group of contributing factors. Similarly, low levels of constructive community involvement (e.g. religious activity) and higher levels of delinquent activity had significant PAR. Current depressed mood had relatively high PAR whereas negative self-cognitions had relatively low PAR.
  
  
  CONCLUSIONS
  Poor affect regulation, existent depressed mood, and accompanying negative cognitions are important potential intervention targets. Our findings also suggest expanding the focus of preventive interventions to encompass all interpersonal and community domains of the adolescent experience.
authors.affiliation: Section of Developmental and Behavioral Pediatrics, Department of Pediatrics, University of Chicago, Chicago, Illinois, USA.
authors.forename: Karin Vander Ploeg
authors.initials: KV
authors.lastname: Booth
authors.forename: David
authors.initials: D
authors.lastname: Paunesku
authors.forename: Michael
authors.initials: M
authors.lastname: Msall
authors.forename: Joshua
authors.initials: J
authors.lastname: Fogel
authors.forename: Benjamin W
authors.initials: BW
authors.lastname: Van Voorhees
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D003863:Depression / Q000517:prevention & control*; D005260:Female; D006304:Health Status; D006801:Humans; D015994:Incidence; D007398:Interpersonal Relations; D008297:Male; D008603:Mental Health; D000297:Psychology, Adolescent; D012111:Residence Characteristics; D012307:Risk Factors; D012725:Sexual Behavior; D012959:Socioeconomic Factors; D055815:Young Adult