title: Palladium-catalyzed cross coupling reaction of benzyl bromides with diazoesters for stereoselective synthesis of (E)-alpha,beta-diarylacrylates.
abstract: A Pd-catalyzed cross-coupling reaction of benzyl bromides with alpha-aryldiazoesters is described, and E-alpha,beta-diarylacrylates were obtained in good yields and excellent E-to-Z selectivity (>20:1).
authors.affiliation: Department of Applied Biology and Chemical Technology and Open Laboratory of Chirotechnology, Institute of Molecular Technology for Drug Discovery and Synthesis, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong. bcwyyu@inet.polyu.edu.hk
authors.forename: Wing-Yiu
authors.initials: WY
authors.lastname: Yu
authors.forename: Yuk-Tai
authors.initials: YT
authors.lastname: Tsoi
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Albert S C
authors.initials: AS
authors.lastname: Chan
mesh_terms: D000179:Acrylates / Q000138:chemical synthesis* / Q000737:chemistry; D000475:Alkenes / Q000737:chemistry; D001391:Azo Compounds / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D000179:Acrylates; D000475:Alkenes; D001391:Azo Compounds; D001593:Benzyl Compounds; C006666:azoester; D010165:Palladium; C038682:benzyl bromide