Correlation of glucose concentrations in maternal serum and amniotic fluid in high-risk pregnancies.
OBJECTIVE
We sought to determine whether a correlation exists between maternal serum glucose and amniotic fluid glucose in high-risk pregnancies.


METHODS
We conducted a prospective cross-sectional study of 60 patients, between 15 and 38 weeks' gestation, undergoing amniocentesis between March 2006 and April 2007. Participants underwent amniocentesis with evaluation of amniotic fluid glucose and maternal finger stick glucose. Data were collected on maternal demographics, gestational age, presence of diabetes or chorioamnionitis, use of betamethasone, and body mass index. Statistical analyses included Spearman rho correlations.


RESULTS
A positive correlation was found between maternal serum glucose and amniotic fluid glucose (r = 0.401, P < .01), and amniotic fluid index and diabetes (r = 0.367, P < .05). An inverse correlation was found between amniotic fluid glucose and chorioamnionitis (r = -0.499, P < .01).


CONCLUSIONS
Maternal hyperglycemia directly influences amniotic fluid glucose levels and may result in an elevated amniotic fluid glucose value.
Rinala
Sara G
SG
Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, OH 45220, USA.
Dryfhout
Vicki L
VL
Lambers
Donna S
DS
D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism*; D002821:Chorioamnionitis / Q000453:epidemiology / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000378:metabolism*; D011446:Prospective Studies; D012307:Risk Factors; D055815:Young Adult
D001786:Blood Glucose