title: P16 expression in odontogenic tumors.
abstract: OBJECTIVE
  The aim of the study was to examine the immunohistochemical expression of a cell-cycle-related factor (p16) in order to elucidate its role in the growth and diffusion of odontogenic tumors.
  
  
  METHODS
  Thirty-six odontogenic tumors were divided into two groups according to their clinical behavior: group A and group B composed of tumors at low and high risk of recurrences, respectively. The ANOVA test was used to detect differences between the two groups.
  
  
  RESULTS
  p16 was expressed in both groups, but with different localization. A statistically significant difference was found in p16 expression of peripheral cells, with an increase in the expression in group B compared to group A (P < 0.05). In addition, there was no significant difference in p16 positive expression of the central cells of odontogenic tumors, which was high in both groups.
  
  
  CONCLUSIONS
  The present data show a correlation between p16 expression and the biological behavior of odontogenic tumors.
authors.affiliation: Dental School, University of Chieti-Pescara, Chieti, Italy.
authors.forename: Luciano
authors.initials: L
authors.lastname: Artese
authors.forename: Adriano
authors.initials: A
authors.lastname: Piattelli
authors.forename: Corrado
authors.initials: C
authors.lastname: Rubini
authors.forename: Gala
authors.initials: G
authors.lastname: Goteri
authors.forename: Vittoria
authors.initials: V
authors.lastname: Perrotti
authors.forename: Giovanna
authors.initials: G
authors.lastname: Iezzi
authors.forename: Marcello
authors.initials: M
authors.lastname: Piccirilli
authors.forename: Francesco
authors.initials: F
authors.lastname: Carinci
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009364:Neoplasm Recurrence, Local / Q000737:chemistry / Q000473:pathology; D009808:Odontogenic Tumors / Q000737:chemistry* / Q000473:pathology*; D018570:Risk Assessment
chemical_list: D014408:Biomarkers, Tumor; C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D009363:Neoplasm Proteins