Leptomeningeal metastasis from ovarian carcinoma successfully treated by the intraventricular administration of methotrexate.
A 60-year-old woman with a history of ovarian carcinoma and complaining of gait instability, dizziness, nausea, and a right temporal headache visited a neurologist. A diagnosis of leptomeningeal metastasis was made, based on the results of a cerebrospinal fluid examination. After the administration of intrathecal methotrexate, her neurological complaints disappeared. An Ommaya intraventricular reservoir was inserted, and methotrexate administration was continued for 11 months, until another recurrence was found in her pelvis. Although uncommon, the possibility of leptomeningeal metastasis from ovarian carcinoma should be considered; in such cases, treatment with intraventricular methotrexate may be effective and feasible and should be considered as a treatment strategy.
Goto
Yasushi
Y
National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
Katsumata
Noriyuki
N
Nakai
Shunichi
S
Sasajima
Yuko
Y
Yonemori
Kan
K
Kouno
Tsutomu
T
Shimizu
Chikako
C
Ando
Masashi
M
Fujiwara
Yasuhiro
Y
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D005260:Female; D005682:Gadolinium; D006801:Humans; D007276:Injections, Intraventricular; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology*
D000964:Antimetabolites, Antineoplastic; D005682:Gadolinium; D008727:Methotrexate