Effectiveness of hemodialysis in acute dapsone overdose-a case report.
The use of dapsone is increasing even though overdose is rarely reported and physicians must be aware of its toxicity and management. Mortality can occur due to methemoglobinemia and hemolytic anemia. Although activated charcoal and methylene blue are recommended, the use of hemodialysis is reported only in few studies. Literature on the kinetic profile indicates that 50% to 80% of dapsone is protein bound and indicates a possibility to dialyze the unbound form. This study describes a case of deliberate severe dapsone overdose with cyanosis, methemoglobinemia, and hemolytic anemia, which improved after repetitive hemodialysis.
Thunga
Girish
G
Department of Pharmacy Practice, SS Cancer Hospital and Research Center, Manipal College of Pharmaceutical Sciences, Manipal 576104, India.
Sam
Kishore Gnana
KG
Patel
Dipish
D
Khera
Kanav
K
Sheshadhri
Subha
S
Bahuleyan
Shibu
S
Vansalan
Rohit
R
Pandit
Vinay R
VR
Manohar
Chetan
C
D003622:Dapsone / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D007917:Leprostatic Agents / Q000506:poisoning*; D008297:Male; D006435:Renal Dialysis; D013406:Suicide, Attempted; D016896:Treatment Outcome; D055815:Young Adult
D007917:Leprostatic Agents; D003622:Dapsone