Malformations of the epididymis, incomplete regression of the mesonephric tubules and hyperplasia of Leydig cells in canine persistence of Müllerian duct syndrome.
Persistence of the Müllerian duct syndrome (PMDS) is a rare form of pseudohermaphroditism characterized by the presence of uterus and oviducts in otherwise normally differentiated SRY-positive 78 XY canine males. Undescended testicles are also common. We report a case of a male PMDS dog with a uterus and bilateral cryptorchidism. The dog had an incomplete regression of the mesonephric tubules. As a consequence of this an abnormally enlarged head of the epididymis was observed. In addition, an extreme reduction in size of both the body and the tail was found. Microscopic examination of both testicles revealed bilateral hyperplasia of Leydig cells. The progesterone blood level was measured by ELISA and was found to be abnormally high (3.18 ng/ml) compared to that of normal male dogs (lower than 1 ng/ml). Three months after surgical removal of the internal genitalia, the serum progesterone, testosterone and oestradiol levels were normal for a castrated male dog.
Whyte
Ana
A
Department of Animal Pathology, Faculty of Veterinary Sciences, 50013 Zaragoza, Spain.
Monteagudo
Luis V
LV
Díaz-Otero
Angel
A
Lebrero
M Eugenia
ME
Tejedor
M Teresa
MT
Falceto
M Victoria
MV
Whyte
Jaime
J
Gallego
Margarita
M
D000818:Animals; D002987:Clitoris / Q000002:abnormalities / Q000473:pathology; D012734:Disorders of Sex Development; D004285:Dogs; D004822:Epididymis / Q000002:abnormalities*; D004958:Estradiol / Q000097:blood; D005260:Female; D006965:Hyperplasia / Q000473:pathology / Q000662:veterinary; D007985:Leydig Cells / Q000473:pathology*; D008297:Male; D009095:Mullerian Ducts / Q000473:pathology*; D009919:Orchiectomy; D012016:Reference Values; D013577:Syndrome; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D004958:Estradiol