[The influence of tumor cells spreading in blood to relapse and distant metastasis of hepatocellular carcinoma after surgery].
OBJECTIVE
To study the relationship between peripheral blood hepatocellular carcinoma cells-associated AFP mRNA and tumor relapse and metastasis.


METHODS
To detect several blood samples from the HCC patients by nested RT-PCR to find out AFP mRNA after 24 h, 72 h and one week and 4 weeks after surgery, and followed up the HCC patients for 1, 2, 3 years.


RESULTS
There were 7 patients occurred relapse or distant metastasis in 12 patients with AFP mRNA positive (7/12, 58.3%), there were 5 patients occurred relapse in 19 patients with AFP mRNA negative (5/19, 26.3%) within 1 year, there was 4 patients occurred relapse in second year (9/19, 47.3%); 5 patients occurred relapse in third year (10/19, 52.6%). Obvious connection between patients AFP mRNA positive and AFP mRNA negative was observed (P < 0.01).


CONCLUSIONS
HCC with AFP mRNA positive has more change to be recurrent compared with HCC patients with AFP mRNA negative.
LIU
Yang
Y
Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China. yliu6633@yahoo.com.cn
ZHANG
Guo-tong
GT
WU
Meng-chao
MC
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009360:Neoplastic Cells, Circulating; D011184:Postoperative Period; D012333:RNA, Messenger / Q000097:blood; D000509:alpha-Fetoproteins / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D000509:alpha-Fetoproteins