X-ray fluorescent CT imaging of cerebral uptake of stable-iodine perfusion agent iodoamphetamine analog IMP in mice.
Using X-ray fluorescent computed tomography (XFCT), the in vivo and ex vivo cerebral distribution of a stable-iodine-labeled cerebral perfusion agent, iodoamphetamine analog (127I-IMP), has been recorded in the brains of mice. In vivo cerebral perfusion in the cortex, hippocampus and thalamus was depicted at 0.5 mm in-plane spatial resolution. Ex vivo XFCT images at 0.25 mm in-plane spatial resolution allowed the visualisation of the detailed structures of these regions. The quality of the XFCT image of the hippocampus was comparable with the 125I-IMP autoradiogram. These results highlight the sensitivity of XFCT and its considerable potential to evaluate cerebral perfusion in small animals without using radioactive agents.
Takeda
Tohoru
T
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba-shi, Ibaraki 305-8575, Japan. ttakeda@md.tsukuba.ac.jp
Wu
Jin
J
Huo
Qingkai
Q
Yuasa
Tetsuya
T
Hyodo
Kazuyuki
K
Dilmanian
F Avraham
FA
Akatsuka
Takao
T
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging*; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation; D006624:Hippocampus / Q000098:blood supply / Q000000981:diagnostic imaging; D007090:Image Interpretation, Computer-Assisted; D007456:Iodine Isotopes; D020367:Iofetamine / Q000493:pharmacokinetics*; D051379:Mice; D019047:Phantoms, Imaging; D013788:Thalamus / Q000098:blood supply / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed / Q000379:methods
D007456:Iodine Isotopes; D020367:Iofetamine