title: Hetero-seeding and solid mixture to obtain new crystalline forms.
abstract: Para-methyl benzyl alcohol (p-MeBA II) and para-chloro benzyl alcohol (p-ClBA) are quasi-isostructural and share the same hydrogen-bond patterns, but their crystals are not isomorphous. No new polymorphs could be obtained by conventional polymorph screening based on different solvents and different crystallization conditions. Formation of a new polymorph of p-MeBA named p-MeBA I, isomorphous with the crystal of p-ClBA, was induced by hetero-seeding with a small quantity of powdered p-ClBA added to a supersaturated solution of p-MeBA in hexane, while seeding of p-ClBA with p-MeBA II failed to give a new phase of p-ClBA isomorphous with known crystalline p-MeBA II. Mixed crystals of p-MeBA and p-ClBA were also prepared with different p-MeBA/p-ClBA ratios to understand the role of the different functional groups in the crystal structure. Crystal phases were characterized by combined use of single-crystal and powder X-ray diffraction, differential scanning calorimetry, and solid-state NMR spectroscopy.
authors.affiliation: Dipartimento di Chimica G. Ciamician, Università degli studi di Bologna, Via Selmi 2, 40126 Bologna, Italy. dario.braga@unibo.it
authors.forename: Dario
authors.initials: D
authors.lastname: Braga
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Grepioni
authors.forename: Lucia
authors.initials: L
authors.lastname: Maini
authors.forename: Marco
authors.initials: M
authors.lastname: Polito
authors.forename: Katia
authors.initials: K
authors.lastname: Rubini
authors.forename: Michele R
authors.initials: MR
authors.lastname: Chierotti
authors.forename: Roberto
authors.initials: R
authors.lastname: Gobetto