Therapeutic potential of resveratrol in Alzheimer's disease.
Several epidemiological studies indicate that moderate consumption of red wine is associated with a lower incidence of dementia and Alzheimer's disease. Red wine is enriched in antioxidant polyphenols with potential neuroprotective activities. Despite scepticism concerning the bioavailability of these polyphenols, in vivo data have clearly demonstrated the neuroprotective properties of the naturally occurring polyphenol resveratrol in rodent models for stress and diseases. Furthermore, recent work in cell cultures and animal models has shed light on the molecular mechanisms potentially involved in the beneficial effects of resveratrol intake against the neurodegenerative process in Alzheimer's disease.
Vingtdeux
Valérie
V
Litwin-Zucker Research Center for the Study of Alzheimer's Disease, The Feinstein Institute for Medical Research, North Shore-LIJ, Manhasset, NY 11030, USA. vdidier@nshs.edu
Dreses-Werringloer
Ute
U
Zhao
Haitian
H
Davies
Peter
P
Marambaud
Philippe
P
D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000627:therapeutic use*; D003704:Dementia / Q000188:drug therapy / Q000473:pathology; D005419:Flavonoids / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D009410:Nerve Degeneration / Q000188:drug therapy / Q000473:pathology; D010636:Phenols / Q000737:chemistry / Q000627:therapeutic use; D059808:Polyphenols; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000627:therapeutic use*; D014920:Wine
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol