title: [Association of the beta2-adrenergic receptor gene C659G polymorphism and essential hypertension in Xinjiang Kazakans.].
abstract: OBJECTIVE
  To investigate the relationship between human beta2-Adrenergic Receptor (ADRB2) gene C659G polymorphism and essential hypertension in Xinjiang Kazakans.
  
  
  METHODS
  Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the C659G polymorphism of ADRB2 gene in 435 Kazakans including 273 hypertensives (EH) and 162 normotensives (NT) and genotype frequencies between EH and NT were analyzed.
  
  
  RESULTS
  The genotype frequencies (CC, CG, GG) of the C659G allele were 85.75%, 13.79%, 0.64% respectively and the C659 and G659 allele frequencies were 7.36%, 92.64% in this cohort. The ADRB2 genotype distribution and the allele frequencies of C659 and G659 were significantly higher in EH than those in NT (all P < 0.05). The G allele is a risk factor contributed to hypertension (OR 12.37). After adjustment for age and BMI, the systolic and diastolic blood pressure levels were significant higher in CG + GG genotype group compared with CC genotype group (P < 0.05).
  
  
  CONCLUSIONS
  There was significant association between the C659G polymorphism of ADRB2 gene and essential hypertension in Xinjiang Kazakans suggesting a role of ADRB2 gene C659G polymorphism in the development of hypertension in Xinjiang Kazakans.
authors.affiliation: Hypertension Institute of Xinjiang, Hypertension Unit of the People's Hospital of Xinjiang Uygur Autonomous Region, Urumuqi 830001, China.
authors.forename: Zhi-Tao
authors.initials: ZT
authors.lastname: Yan
authors.forename: Nan-Fang
authors.initials: NF
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Yang
authors.forename: Jun-Qiang
authors.initials: JQ
authors.lastname: Pan
authors.forename: Ke-Jian
authors.initials: KJ
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D016022:Case-Control Studies; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension; D011110:Polymorphism, Genetic; D011941:Receptors, Adrenergic
chemical_list: D011941:Receptors, Adrenergic