title: Pulmonary function and respiratory muscle strength in chronic renal failure patients on hemodialysis.
abstract: OBJECTIVE
  To evaluate pulmonary function and respiratory muscle strength in chronic renal failure patients, correlating these variables with hemodialysis-related weight fluctuation; to study the correlation between the duration hemodialysis and potential respiratory alterations.
  
  
  METHODS
  Seventeen patients (median age, 47 years; interquartile range, 41-52 years), submitted to three weekly hemodialysis sessions for a median of 27 months (interquartile range, 14-55) were evaluated. Twelve of the patients were male. The patients underwent spirometry. Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) were measured prior to and after the first hemodialysis session of the week. Body weight was quantified prior to and after each of the three weekly sessions.
  
  
  RESULTS
  Before the first hemodialysis session of the week, 8 patients presented mild restrictive defect, which normalized after the session in 2 of those patients. After dialysis, there was a significant increase in forced vital capacity (p = 0.02) and a significant decrease in body weight (p = 0.0001). Weight fluctuation over 3 days without hemodialysis tended to correlate with the variation in forced vital capacity in the first weekly session (r = 0.47; p = 0.055). Duration of hemodialysis correlated with predialysis MIP (r = -0.3; p = 0.03) and MEP (r = -0.63; p = 0.006).
  
  
  CONCLUSIONS
  More pronounced weight gain in the interdialytic period is associated with worsening of lung function, which is almost fully reversible by hemodialysis. In addition, longer duration of hemodialysis is associated with decreased respiratory muscle strength.
authors.affiliation: Departamento de Fisioterapia, Universidade Estadual de Londrina. dkovelis@yahoo.com.br
authors.forename: Demetria
authors.initials: D
authors.lastname: Kovelis
authors.forename: Fábio
authors.initials: F
authors.lastname: Pitta
authors.forename: Vanessa Suziane
authors.initials: VS
authors.lastname: Probst
authors.forename: Celeide Pinto Aguiar
authors.initials: CP
authors.lastname: Peres
authors.forename: Vinicius Daher Alvares
authors.initials: VD
authors.lastname: Delfino
authors.forename: Altair Jacob
authors.initials: AJ
authors.lastname: Mocelin
authors.forename: Antônio Fernando
authors.initials: AF
authors.lastname: Brunetto
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008451:Maximal Voluntary Ventilation / Q000502:physiology; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology*; D018908:Muscle Weakness / Q000209:etiology / Q000503:physiopathology; D006435:Renal Dialysis; D012132:Respiratory Muscles / Q000503:physiopathology*; D013147:Spirometry; D013997:Time Factors; D014797:Vital Capacity / Q000502:physiology; D015430:Weight Gain / Q000502:physiology