Long-range diffusion of hyperpolarized 3He in rats.
Based on a stimulated-echo technique, a method to construct an apparent diffusion coefficient (ADC) map of hyperpolarized (3)He in a long-range diffusion scale is presented with a phase-cycle alternative to remove all unwanted echoes. The approach was successfully applied to determine in vivo diffusion constants in rat lungs. The ADC values in healthy rats show a good agreement with reported values for diffusion times of approximately. These long diffusivity measurements may be sensitive to detect emphysema progression or tissue remodeling and thus have enormous potential for the diagnosis and tracking of disease progression and for drug evaluation.
Rodríguez
Ignacio
I
Departamento de Química Física II, Facultad de Farmacia, Universidad Complutense Madrid, CIBER de enfermedades respiratorias, Madrid, Spain.
Pérez-Sánchez
José Manuel
JM
Peces-Barba
Germán
G
Kaulisch
Thomas
T
Stiller
Detlef
D
Ruiz-Cabello
Jesús
J
D000465:Algorithms; D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006371:Helium / Q000737:chemistry*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007477:Ions; D007554:Isotopes / Q000737:chemistry; D008168:Lung / Q000033:anatomy & histology* / Q000737:chemistry*; D008297:Male; D019275:Radiopharmaceuticals / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media; D007477:Ions; D007554:Isotopes; D019275:Radiopharmaceuticals; D006371:Helium