title: Pneumomediastinum and subcutaneous emphysema secondary to amyopathic dermatomyositis with cryptogenic organizing pneumonia in invasive breast cancer: a case report and review of literature.
abstract: Amyopathic dermatomyositis (ADM) is recognized as a variant phenotype of dermatomyositis and characterized by typical skin manifestations without evidence of muscular inflammation. While interstitial lung disease (ILD) is occasionally found as one of the lung manifestations in ADM patients, the development of a pneumomediastinum and/or subcutaneous emphysema in this disease entity is one of the extremely rare pulmonary complications. These latter complicated pulmonary manifestations have been usually reported in idiopathic ADM with ILD without any other associated medical conditions. We report a case presented with the spontaneous pneumomediastinum and subcutaneous emphysema in both ADM and cryptogenic organizing pneumonia during adjuvant chemotherapy based on cyclophosphamide for breast cancer.
authors.affiliation: Department of General Surgery, Catholic University of Daegu School of Medicine, Daegu, South Korea.
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Park
authors.forename: Yoon-Seup
authors.initials: YS
authors.lastname: Kum
authors.forename: Kyung-Chan
authors.initials: KC
authors.lastname: Kim
authors.forename: Jung-Yoon
authors.initials: JY
authors.lastname: Choe
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Seong-Kyu
authors.initials: SK
authors.lastname: Kim
mesh_terms: D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D017024:Chemotherapy, Adjuvant / Q000379:methods; D018549:Cryptogenic Organizing Pneumonia / Q000175:diagnosis*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications* / Q000175:diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008168:Lung / Q000000981:diagnostic imaging; D008478:Mediastinal Emphysema / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011859:Radiography; D013352:Subcutaneous Emphysema / Q000000981:diagnostic imaging* / Q000209:etiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide