title: Analysis of peripheral blood lymphocyte phenotypes and Th1/Th2 cytokines profile in the systemic immune responses of Helicobacter pylori infected individuals.
abstract: H. pylori elicits specific humoral and cellular immune responses in the mucosal immune system. However, the type and extent of T lymphocyte response in the systemic immune system is not clear for H. pylori positive patients. In this study, peripheral blood T lymphocyte phenotypes and serum Th1/Th2 based cytokines of 32 H. pylori positive patients were analyzed and compared to those of healthy controls. While alphabeta TCR(+) lymphocytes and their phenotype analysis were not significantly different to those of healthy controls, the percentage of pan gammadelta TCR(+) lymphocytes was up to 2.4 times greater in the H. pylori positive group then in healthy controls. Furthermore, significant increases in IL-10 concentrations in serum samples of H. pylori patients indicated that their immune systems had switched toward a Th2 type immune response. The correlation between phenotype and type of T cell response in the peripheral blood during H. pylori infection is discussed.
authors.affiliation: Immunology Department, Faculty of Medicine, Zonguldak Karaelmas University, Kozlu, Zonguldak, Turkey. kayhanbasak@hotmail.com
authors.forename: Basak
authors.initials: B
authors.lastname: Kayhan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Arasli
authors.forename: Haci
authors.initials: H
authors.lastname: Eren
authors.forename: Selim
authors.initials: S
authors.lastname: Aydemir
authors.forename: Burcak
authors.initials: B
authors.lastname: Kayhan
authors.forename: Elif
authors.initials: E
authors.lastname: Aktas
authors.forename: Ishak
authors.initials: I
authors.lastname: Tekin
mesh_terms: D000328:Adult; D005260:Female; D005434:Flow Cytometry; D016481:Helicobacter Infections / Q000276:immunology*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta; D016753:Interleukin-10