title: Revelation of Brugada electrocardiographic pattern during a febrile state.
abstract: The prevalence of the Brugada-type ECG and its natural history are still unclear. The Brugada syndrome is usually identified by a characteristic Brugada-type ECG that consists of ST elevation of a coved type in the precordial leads V1 to V3 and ventricular fibrillation that can lead to sudden cardiac death, although affected individuals may have a normal ECG. Mutations in the cardiac sodium channel gene SCN5A, which encodes the alpha-subunit of the human cardiac voltage-dependent Na+ channel (Na(v)1.5), are identified in 15-30% of patients with Brugada syndrome. Most SCN5A mutations lead to a 'loss-of-function' phenotype, reducing the Na+ current during the early phases of the action potential. Several nongenetic factors have been mentioned in the literature as possible inductors of the ECG pattern resembling Brugada syndrome. As such, a Brugada-type ECG may appear in some patients during febrile states and in those who are under the influence of cocaine and pharmaceutical drugs that have a sodium channel-blocking effect. It has been also reported that chest pain and ST elevation Brugada pattern occur during febrile states. We present a case of revelation of Brugada pattern in a 61-year-old Italian man complaining of pain in the left hipocondrium during a febrile state. Also this report confirms that Brugada pattern should be considered as one of differential diagnoses when we examine the patients during a febrile state.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Patanè
authors.forename: Filippo
authors.initials: F
authors.lastname: Marte
authors.forename: Felice Carmelo
authors.initials: FC
authors.lastname: La Rosa
authors.forename: Antonio
authors.initials: A
authors.lastname: Albanese
authors.forename: Roberto
authors.initials: R
authors.lastname: La Rocca
authors.forename: Santa Alessandra
authors.initials: SA
authors.lastname: Villari
mesh_terms: D053840:Brugada Syndrome / Q000150:complications*; D002037:Bundle-Branch Block / Q000150:complications; D005334:Fever / Q000150:complications*; D006349:Heart Valve Diseases / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000150:complications