title: Peripheral blood CD5-positive B lymphocytes (B-1a cells) after allogeneic stem cell transplantation for acute myeloid leukaemia in humans.
abstract: BACKGROUND
  Only few data are available in literature regarding the reconstitution of B- 1a cells after allogeneic bone marrow transplantation performed for haematological malignancies.
  
  
  METHODS
  In this study we used flow cytometry to assess the reconstitution of the peripheral blood B-1a cell compartment after allogeneic peripheral blood stem cell transplantation. Cytometric analyses were performed over time on 11 consecutive patients undergoing allogeneic peripheral blood stem cell transplantation for acute myeloid leukaemia in our Haematology Unit and the results were compared with available data regarding B- 1a cell reconstitution after allogeneic bone marrow stem cell transplantation.
  
  
  RESULTS
  In spite of an earlier recovery of B-1a cells in the peripheral blood after allogeneic bone marrow transplantation, the reconstitution of this B-cell subset was similar, regardless of the source of stem cells employed.
  
  
  CONCLUSIONS
  Further studies are necessary in order to clarify the origin of B-1a cells in humans in health and illness.
authors.affiliation: Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Università di Verona, Italy. dino.veneri@univr.it
authors.forename: Dino
authors.initials: D
authors.lastname: Veneri
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Donata
authors.initials: D
authors.lastname: de Sabata
authors.forename: Silvia
authors.initials: S
authors.lastname: Ledro
authors.forename: Antonio
authors.initials: A
authors.lastname: Vella
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ortolani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pizzolo
authors.forename: Fabio
authors.initials: F
authors.lastname: Benedetti
mesh_terms: D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000276:immunology; D018956:CD5 Antigens / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000276:immunology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous / Q000276:immunology; D055815:Young Adult
chemical_list: D018956:CD5 Antigens