title: Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report.
abstract: BACKGROUND
  Obsessive-compulsive disorder is associated with a relevant impairment in social and interpersonal functioning and severe disability. This seems to be particularly true for the poor insight subtype, characterised by a lack of consciousness of illness and, consequently, compliance with treatment. Poor responsiveness to serotonergic drugs in poor insight obsessive-compulsive patients may also require an augmentation therapy with atypical antipsychotics.
  
  
  METHODS
  We reviewed a case in which a patient with a long history of poor insight obsessive-compulsive disorder was treated with a high dosage of serotonin reuptake inhibitors.
  
  
  RESULTS
  The treatment resulted in a poor outcome. This patient was therefore augmentated with aripiprazole.
  
  
  CONCLUSIONS
  Doctors should consider aripiprazole as a possible augmentation strategy for serotonergic poor responder obsessive-compulsive patients, but further research on these subjects is needed.
authors.affiliation: Dipartimento di Neuroscienze, Oftalmologia e Genetica (DINOG), Sezione di Psichiatria, Università di Genova, Italy. dott.fornaro@gmail.com
authors.forename: Michele
authors.initials: M
authors.lastname: Fornaro
authors.forename: Filippo
authors.initials: F
authors.lastname: Gabrielli
authors.forename: Chiara
authors.initials: C
authors.lastname: Mattei
authors.forename: Valentina
authors.initials: V
authors.lastname: Vinciguerra
authors.forename: Pantaleo
authors.initials: P
authors.lastname: Fornaro