title: Phototocatalytic lithography of poly(propylene sulfide) block copolymers: toward high-throughput nanolithography for biomolecular arraying applications.
abstract: Photocatalytic lithography (PCL) is an inexpensive, fast, and robust method of oxidizing surface chemical moieties to produce patterned substrates. This technique has utility in basic biological research as well as various biochip applications. We report on porphyrin-based PCL for patterning poly(propylene sulfide) block copolymer films on gold substrates on the micrometer and submicrometer scales. We confirm chemical patterning with imaging ToF-SIMS and low-voltage SEM. Biomolecular patterning on micrometer and submicrometer scales is demonstrated with proteins, protein-linked beads. and fluorescently labeled proteins.
authors.affiliation: Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory L-211, 7000 East Avenue, Livermore, California, USA. bearinger1@llnl.gov
authors.forename: Jane P
authors.initials: JP
authors.lastname: Bearinger
authors.forename: Gary
authors.initials: G
authors.lastname: Stone
authors.forename: Amy L
authors.initials: AL
authors.lastname: Hiddessen
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Dugan
authors.forename: Ligang
authors.initials: L
authors.lastname: Wu
authors.forename: Philip
authors.initials: P
authors.lastname: Hailey
authors.forename: James W
authors.initials: JW
authors.lastname: Conway
authors.forename: Tobias
authors.initials: T
authors.lastname: Kuenzler
authors.forename: Lydia
authors.initials: L
authors.lastname: Feller
authors.forename: Simona
authors.initials: S
authors.lastname: Cerritelli
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Hubbell
mesh_terms: D000327:Adsorption; D002384:Catalysis; D006046:Gold / Q000737:chemistry; D008567:Membranes, Artificial; D018625:Microscopy, Atomic Force; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D010777:Photochemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry; D040081:Protein Array Analysis / Q000379:methods*; D018629:Spectrometry, Mass, Secondary Ion; D019809:Streptavidin / Q000737:chemistry; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D008567:Membranes, Artificial; D011166:Porphyrins; D013440:Sulfides; C515871:poly(ethylene glycol)-stabilized poly(propylene sulfide); D011092:Polyethylene Glycols; D006046:Gold; D019809:Streptavidin