Role of acidosis, NMDA receptors, and acid-sensitive ion channel 1a (ASIC1a) in neuronal death induced by ischemia.
This review collects data on the influence of intracellular and extracellular acidosis on neuronal viability and the effect of acidosis on neuronal damage progressing under brain ischemia/hypoxia. Particular attention is devoted to the involvement of ionotropic glutamic receptors and acid-sensitive ion channel 1a in these processes.
Isaev
N K
NK
Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119991, Russia. isaev@genebee.msu.su
Stelmashook
E V
EV
Plotnikov
E Y
EY
Khryapenkova
T G
TG
Lozier
E R
ER
Doludin
Y V
YV
Silachev
D N
DN
Zorov
D B
DB
D062565:Acid Sensing Ion Channels; D000138:Acidosis / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000503:physiopathology; D016923:Cell Death; D018698:Glutamic Acid / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D000860:Hypoxia / Q000378:metabolism / Q000503:physiopathology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism*; D015222:Sodium Channels / Q000235:genetics / Q000378:metabolism*
C568266:ASIC1 protein, human; D062565:Acid Sensing Ion Channels; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate; D015222:Sodium Channels; D018698:Glutamic Acid