title: [Effects of antiarrhythmic drug use on atrial fibrillation recurrence in atrial fibrillation patients post circumferential pulmonary vein ablation].
abstract: OBJECTIVE
  This prospective and randomize-controlled trial was designed to investigate the effects of antiarrhythmic drug use (AADs) on atrial fibrillation (AF) recurrence in atrial fibrillation patients post circumferential pulmonary vein ablation (CAPV).
  
  
  METHODS
  Seventy-four consecutive AF patients underwent CAPV (41 paroxysmal and 33 drug refractory AF) were randomly assigned to receive placebo (Group A) or AADs (Group B) for 3 months. Monthly standard electrocardiograms (ECG) and Holter monitoring were performed to assess AF recurrences during 17 - 28 months follow-up.
  
  
  RESULTS
  CAPV was successful in all patients. The recurrence rate of AF in Group B was significantly lower than that in Group A at 3 months post CAPV (13.5% vs. 37.8%, P < 0.01) and similar thereafter (29.7% vs. 24.3% at 12 months and 8.1% vs. 8.1% at more than 12 months, all P > 0.05). There was also no significant difference in terms of total recurrence rate between the two groups (37.8% vs. 32.4%, P > 0.05).
  
  
  CONCLUSIONS
  Post CAPV antiarrhythmic drug therapy could only decrease the early AF recurrence rate but was not effective for decreasing AF recurrence rate on later stage.
authors.affiliation: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Wu
authors.forename: Hong
authors.initials: H
authors.lastname: Jiang
authors.forename: Cong-xin
authors.initials: CX
authors.lastname: Huang
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: He
authors.initials: H
authors.lastname: Huang
authors.forename: Yue-ling
authors.initials: YL
authors.lastname: Wang
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Wang
authors.forename: Hua-fen
authors.initials: HF
authors.lastname: Liu
authors.forename: Xin-hong
authors.initials: XH
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000628:therapy; D017115:Catheter Ablation / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis; D011446:Prospective Studies; D011667:Pulmonary Veins; D012008:Recurrence
chemical_list: D000889:Anti-Arrhythmia Agents