D2-40 immunohistochemistry--so far!
D2-40 is a commercially available monoclonal antibody directed against human podoplanin, a transmembrane mucoprotein that is expressed in lymphatic endothelial cells. Since its introduction, D2-40 immunoexpression has been described in a variety of lymphovascular neoplasms including lymphangioma, Kaposi sarcoma, and hemangioendothelioma, as well as nonvascular neoplasms such as epithelioid mesothelioma, seminoma, and hemangioblastoma. More recently, D2-40 immunoexpression has been reported in primary adrenal cortical tumors, schwannomas, and adnexal tumors of the skin. This brief review provides an update on the ever-expanding proposed applications of D2-40 immunohistochemistry in surgical pathology.
Kalof
Alexandra N
AN
Department of Pathology, University of Vermont/Fletcher Allen Health Care, Burlington, VT 05401, USA. alexandra.kalof@vtmednet.org
Cooper
Kumarasen
K
D000306:Adrenal Cortex Neoplasms / Q000276:immunology / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000032:analysis; D058846:Antibodies, Monoclonal, Murine-Derived; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D016543:Central Nervous System Neoplasms / Q000276:immunology / Q000473:pathology; D004729:Endothelium, Lymphatic / Q000276:immunology / Q000473:pathology; D018325:Hemangioblastoma / Q000276:immunology / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008202:Lymphangioma / Q000276:immunology / Q000473:pathology; D008654:Mesothelioma / Q000276:immunology / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000473:pathology
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C500987:monoclonal antibody D2-40