title: [A case of advanced gastric cancer successfully treated by S-1 based chemotherapy].
abstract: A 57-year-old patient presented with a loss of appetite and vomiting. Gastrointestinal endoscopy revealed advanced gastric cancer with pyloric stenosis, and CT scan showed multiple liver metastases and paraaortic lymph node metastases. A gastrojejunostomy was performed because of invasion of the pancreas. After 5 courses of S-1 plus cisplatin, both the primary lesion and the paraaortic lymph nodes were reduced in size, and the liver metastases disappeared. Subsequently, a distal gastrectomy was performed. No recurrence was seen for sixteen months from treatment with the oral anticancer drug S-1. At 16 months after second surgery, progression of paraaortic lymph nodes was recognized again, and S-1 plus paclitaxel was administered. After 7 courses of S-1 plus paclitaxel, paraaortic lymph nodes became undetectable. This report describes a case of unresectable advanced gastric cancer treated by S-1 based chemotherapy and surgical method, which resulted in long survival and improvement in quality of life.
authors.affiliation: Dept. of Surgery, Bizen Municipal Hospital, Japan.
authors.forename: Shintaro
authors.initials: S
authors.lastname: Mitsuoka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Onoda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tabuchi
authors.forename: Izumi
authors.initials: I
authors.lastname: Harafuji
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D004338:Drug Combinations; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D005641:Tegafur / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid