title: Derivation and validation of diagnostic criteria for chronic inflammatory demyelinating polyneuropathy.
abstract: To develop diagnostic criteria for chronic inflammatory demyelinating polyneuropathy (CIDP), a retrospective series of patients' records diagnosed by sexpert consensus as CIDP or other chronic polyneuropathies were analyzed. Classification and regression tree analysis was applied to 150 patients to derive a classification rule. According to the rule, diagnosis of CIDP required that a patient have a chronic non-genetic polyneuropathy, progressive for at least eight weeks, without a serum paraprotein and either 1) recordable compound muscle action potentials in > or =75% of motor nerves and either abnormal distal latency in >50% of nerves or abnormal motor conduction velocity in >50% of nerves or abnormal F wave latency in >50% of nerves; or 2) symmetrical onset of motor symptoms, symmetrical weakness of four limbs, and proximal weakness in > or =1 limb. When validated in 117 patients, the rule had 83% sensitivity (95% confidence interval 69%-93%) and 97% specificity (95% confidence interval 89%-99%) and performed better than published criteria.
authors.affiliation: University of Maryland School of Medicine, Department of Neurology, Baltimore, MD, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Koski
authors.forename: M
authors.initials: M
authors.lastname: Baumgarten
authors.forename: L S
authors.initials: LS
authors.lastname: Magder
authors.forename: R J
authors.initials: RJ
authors.lastname: Barohn
authors.forename: J
authors.initials: J
authors.lastname: Goldstein
authors.forename: M
authors.initials: M
authors.lastname: Graves
authors.forename: K
authors.initials: K
authors.lastname: Gorson
authors.forename: A F
authors.initials: AF
authors.lastname: Hahn
authors.forename: R A C
authors.initials: RA
authors.lastname: Hughes
authors.forename: J
authors.initials: J
authors.lastname: Katz
authors.forename: R A
authors.initials: RA
authors.lastname: Lewis
authors.forename: G J
authors.initials: GJ
authors.lastname: Parry
authors.forename: P
authors.initials: P
authors.lastname: van Doorn
authors.forename: D R
authors.initials: DR
authors.lastname: Cornblath
mesh_terms: D003943:Diagnostic Techniques, Neurological / Q000592:standards*; D006801:Humans; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis*; D017410:Practice Guidelines as Topic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity