title: [An investigation and analysis on an outbreak of acute gastroenteritis caused by genogroup I and II norovirus].
abstract: OBJECTIVE
  To investigate the cause of an outbreak characterized by diarrhea and vomit in a middle school in Huzhou City.
  
  
  METHODS
  Comprehensive analysis was conducted based on field epidemiological study, clinical characteristics of the cases and laboratory test.
  
  
  RESULTS
  578 cases of acute gastroenteritis were found. The attack rate was 23.58%. The most frequently observed clinical symptoms were diarrhea, vomiting, abdominal pain and nausea. Some few had fever. Most cases had slight clinical symptom with a course from 1 to 3 days. The cases were distributed in every class, showing no phenomenon of clustering. Norovirus were detected in 11 out of 15 stool samples by using RT-PCR. 6 were genogroup II norovirus. 3 were genogroup I norovirus. enogroup I and II norovirus were detected at the same time in 2 stool samples (the same student with 2 tests). Case-control study showed that drinking unheated bottled water was risk factor (OR = 2.46, 95% CI = 1.19-5.23), and had a dose response relation with the disease (chi = 24.8 P < 0.01). The epidemic was controlled soon through isolating patients during treatment, providing boiled water, disinfecting and health education.
  
  
  CONCLUSIONS
  This was an infectious diarrhea outbreak caused by norovirus. The suspected transmission ways were drinking unheated bottled water and contact daily.
authors.affiliation: Huzhou Municipal CDC of Zhejiang Province, Huzhou 313000, China. hanjk678@163.com
authors.forename: Jian-Kang
authors.initials: JK
authors.lastname: Han
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Shen
authors.forename: Wen-Ting
authors.initials: WT
authors.lastname: Yao
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Lwu
authors.forename: Xiao-Fang
authors.initials: XF
authors.lastname: Wu
mesh_terms: D000208:Acute Disease / Q000453:epidemiology; D000293:Adolescent; D017250:Caliciviridae Infections / Q000453:epidemiology* / Q000821:virology; D016022:Case-Control Studies; D004196:Disease Outbreaks; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D005838:Genotype; D006801:Humans; D008297:Male; D029322:Norovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D014871:Water Microbiology; D014881:Water Supply / Q000032:analysis