title: [Study on the progress of the mechanism of TGF-beta in the scarring and the effect of TCM].
abstract: Transforming growth factor (TGF-beta) plays a central role in wound healing and scarring. TGF-beta is a member of cytokine family, involving cell proliferation, migration, differentiation and apoptosis, which subsequently trigger extracellular matrix (ECM) deposite and collagen overproduction. A number of regulators of TGF-beta expression bave been identified, including Decorin CTGF, etc. TCM can reduced later scarring, and it accelerates wound healing. TCM can reduce the expression of TGF-beta, resistance of fibrosis, so that lighten the development of scar. This article reviewed the mechanism of TGF-beta in the scarring and TCM can decrease the development of scar effected by TGF-beta.
authors.affiliation: School of Acupuncture, Moxibustion & Tuina, Beijing University of Chinese Medicine, Beijing 100029, China. wgls2001@163.com
authors.forename: Rong-Guo
authors.initials: RG
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Yong-Dong
authors.initials: YD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000188:drug therapy / Q000378:metabolism*; D005355:Fibrosis / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008516:Medicine, Chinese Traditional; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta