Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy.
This study was designed to determine whether the functional IL-10 gene polymorphism -1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi and whether interleukin (IL)-10 expression can be correlated with patients' cardiac function. Our results demonstrated that the polymorphic allele, which correlates with lower expression of IL-10, was associated with the development of Chagas disease cardiomyopathy. Accordingly, correlative analysis showed that low IL-10 expression was associated with worse cardiac function, as determined by left-ventricular ejection fraction values. Therefore, the IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.
Costa
Germano C
GC
Laboratory of Cell-Cell Interactions, Department of Morphology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
da Costa Rocha
Manoel Otávio
MO
Moreira
Paula Rocha
PR
Menezes
Cristiane Alves Silva
CA
Silva
Micena R
MR
Gollob
Kenneth J
KJ
Dutra
Walderez O
WO
D000328:Adult; D000368:Aged; D002598:Chagas Cardiomyopathy / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D055815:Young Adult
D016753:Interleukin-10