Molecular scanning of the gene for thioredoxin, an antioxidative and antiapoptotic protein, and genetic susceptibility to type 1 diabetes.
Oxidative stress has been implicated in the destruction of beta cells in type 1 diabetes (T1D). Thioredoxin has been shown to protect cells from oxidative stress and apoptosis. In this study, we screened for sequence variants of the human thioredoxin gene (TXN), and studied the association of the variants in persons with T1D in Japanese. The frequency of the A allele of the G/A SNP in the 3' flanking region was highest in T1D (8.4%), followed by type 2 diabetes (6.8%), and the lowest in the controls (5.9%), suggesting the contribution of TXN polymorphism to susceptibility to T1D.
Ikegami
Hiroshi
H
Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, Osaka, Japan. ikegami@med.kindai.ac.jp
Ono
Masaya
M
Fujisawa
Tomomi
T
Hiromine
Yoshihisa
Y
Kawabata
Yumiko
Y
Yamato
Eiji
E
D024509:3' Flanking Region / Q000235:genetics; D017209:Apoptosis / Q000235:genetics; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D018384:Oxidative Stress / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D013879:Thioredoxins / Q000235:genetics*
D013879:Thioredoxins