title: Immunomodulatory effects of Abnormal Savda Munsiq, a traditional Uighur medicine, on the combined stress mice.
abstract: OBJECTIVE
  To investigate the immunomodulatory effects of ASMq, a herbal preparation used in Traditional Uighur Medicine, on the combined stress mice.
  
  
  METHODS
  The combined stress was induced on mice by application of the electric-foot shock in a cold-dry environment and three different doses of ASMq were orally administered to the animals for 14 days. The effect of ASMq on the immune apparatus weight index, lymphocytes proliferation, serum levels of the cytokines, immunoglobulins, hemolysin and NK cells as well as the phagocytic activity of the macrophages were evaluated.
  
  
  RESULTS
  Oral administration of ASMq was found to increase the thymus and spleen indices, lymphocytes proliferation induced by Con A and LPS, the percentage of CD4(+) in thymus, spleen and peripheral blood and restore the CD4(+)/CD8(+) ratio. The serum concentrations of INF-beta, IL-2, IL-6, IgG, NK cells and hemolysin were also increased. The macrophage phagocytic activity was also enhanced.
authors.affiliation: Traditional Uighur Medicine Department, Xinjiang Medical University, 8 Medical University Road, Urumqi 830054, Xinjiang, China.
authors.forename: Nurmuhammat
authors.initials: N
authors.lastname: Amat
authors.forename: Halmurat
authors.initials: H
authors.lastname: Upur
authors.forename: Adiljan
authors.initials: A
authors.lastname: Ablimit
authors.forename: Aynur
authors.initials: A
authors.lastname: Matsidik
authors.forename: Abdirhim
authors.initials: A
authors.lastname: Yusup
authors.forename: Anake
authors.initials: A
authors.lastname: Kijjoa
mesh_terms: D000818:Animals; D016516:CD4-CD8 Ratio; D004597:Electroshock; D006460:Hemolysin Proteins / Q000378:metabolism; D007107:Immune System / Q000187:drug effects*; D007136:Immunoglobulins / Q000378:metabolism; D007155:Immunologic Factors / Q000494:pharmacology*; D016899:Interferon-beta / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000502:physiology; D019684:Magnoliopsida; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects; D013312:Stress, Physiological / Q000276:immunology*; D013950:Thymus Gland / Q000187:drug effects
chemical_list: D006460:Hemolysin Proteins; D007136:Immunoglobulins; D007155:Immunologic Factors; D007376:Interleukin-2; D015850:Interleukin-6; D010936:Plant Extracts; D016899:Interferon-beta