Sigma-1 receptor knockout mice display a depressive-like phenotype.
Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior.
Sabino
Valentina
V
Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA. vsabino@scripps.edu
Cottone
Pietro
P
Parylak
Sarah L
SL
Steardo
Luca
L
Zorrilla
Eric P
EP
D000818:Animals; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology*; D003863:Depression / Q000503:physiopathology / Q000523:psychology*; D005106:Exploratory Behavior / Q000502:physiology; D005838:Genotype; D007103:Immobilization / Q000523:psychology*; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000502:physiology; D009154:Mutation; D010641:Phenotype; D016133:Polymerase Chain Reaction; D017480:Receptors, sigma / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D013550:Swimming; D000097605:Sigma-1 Receptor
D017480:Receptors, sigma; D000097605:Sigma-1 Receptor