title: [Efficacy of gefitinib according to smoking status in non-small cell lung cancer patients].
abstract: Gefitinib is a molecular targeting agent and more effective in patients with characteristics of oriental ethnicity, female gender, adenocarcinoma and non-smokers. It is sometimes effective in smokers, but few papers have focused on the association between efficacy and smoking history. The aim of this study is to evaluate the association between efficacy of gefitinib and patients' characteristics, especially smoking history. Between July 2002 and September 2006, 89 patients were diagnosed as non-small cell lung cancer and administered gefitinib. Eighty of them were assessable for efficacy and toxicity of gefitinib. Response rate was 16.2% and 39.6%(p=0.031)in smokers and non-smokers. Survival was statistically greater in non-smokers. In smokers, there are more cases which showed response to gefitinib with a lower smoking index and longer duration after smoking cessation. Smoking index and duration after smoking cessation should be considered when gefitinib is administered or EGFR mutation analysis is conducted in patients with non-small cell lung cancer.
authors.affiliation: Dept. of Respiratory Medicine, Juntendo University, School of Medicine, Japan.
authors.forename: Takehito
authors.initials: T
authors.lastname: Shukuya
authors.forename: Michihiro
authors.initials: M
authors.lastname: Hirama
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Yae
authors.forename: Atsuko
authors.initials: A
authors.lastname: Miyaji
authors.forename: Toshiji
authors.initials: T
authors.lastname: Ishiwata
authors.forename: Kayo
authors.initials: K
authors.lastname: Miura
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Seyama
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D005260:Female; D000077156:Gefitinib; D006801:Humans; D008297:Male; D008875:Middle Aged; D011799:Quinazolines / Q000627:therapeutic use*; D012907:Smoking; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D011799:Quinazolines; D000077156:Gefitinib