title: Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy.
abstract: This study was designed to determine whether the functional IL-10 gene polymorphism -1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi and whether interleukin (IL)-10 expression can be correlated with patients' cardiac function. Our results demonstrated that the polymorphic allele, which correlates with lower expression of IL-10, was associated with the development of Chagas disease cardiomyopathy. Accordingly, correlative analysis showed that low IL-10 expression was associated with worse cardiac function, as determined by left-ventricular ejection fraction values. Therefore, the IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.
authors.affiliation: Laboratory of Cell-Cell Interactions, Department of Morphology, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: Germano C
authors.initials: GC
authors.lastname: Costa
authors.forename: Manoel Otávio
authors.initials: MO
authors.lastname: da Costa Rocha
authors.forename: Paula Rocha
authors.initials: PR
authors.lastname: Moreira
authors.forename: Cristiane Alves Silva
authors.initials: CA
authors.lastname: Menezes
authors.forename: Micena R
authors.initials: MR
authors.lastname: Silva
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Gollob
authors.forename: Walderez O
authors.initials: WO
authors.lastname: Dutra
mesh_terms: D000328:Adult; D000368:Aged; D002598:Chagas Cardiomyopathy / Q000235:genetics*; D003430:Cross-Sectional Studies; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D055815:Young Adult
chemical_list: D016753:Interleukin-10