Uncommon cases of immature-type CD56+ natural killer (NK)-cell neoplasms, characterized by expression of myeloid antigen of blastic NK-cell lymphoma.
Immature-type CD56(+) natural killer (NK)-cell neoplasms are classified as either myeloid/NK-cell precursor acute leukemia or blastic NK-cell lymphoma. We identified two cases of immature-type CD56(+) NK-cell neoplasms that were not categorizable as either of these entities. The first case involved a 74-year-old woman presenting with skin eruptions and pancytopenia due to bone marrow necrosis. Skin biopsy specimen revealed CD4(+), CD7(-), CD34(-), CD43(+), CD56(+), CD68(+), muramidase (lysozyme)(+), and myeloperoxidase (MPO)(-), and immunophenotyping of peripheral blood showed CD4(+), CD7(-), CD13(+), CD33(+), CD34(-), CD43(+), CD56(+), cytoplasmic (cy)CD68(+), CD123(+), and HLA-DR(+). The second case involved a 62-year-old man who had bilateral optic nerve tumor and presented with malignant cells in peripheral blood. Cell surface markers of malignant cells showed CD4(+), CD7(-), CD13(+), CD33(+), CD34(-), CD43(+), CD56(+), cyCD68(+), and HLA-DR(+). The phenotypes of tumor cells in both cases were compatible with blastic NK-cell lymphoma, except for the expression of myeloid antigen. Clinical presentations of these cases showed characteristics of both blastic NK-cell lymphoma and myeloid/NK-cell precursor acute leukemia.
Owatari
Satsuki
S
Department of Internal Medicine, National Hospital Organization Kagoshima Medical Center, 8-1 Shiroyama, Kagoshima, 892-0853, Japan. owatari@kagomc2.hosp.go.jp.|Department of Hematology and Immunology, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan. owatari@kagomc2.hosp.go.jp.
Otsuka
Maki
M
Department of Internal Medicine, National Hospital Organization Kagoshima Medical Center, 8-1 Shiroyama, Kagoshima, 892-0853, Japan.
Takeshita
Taketsugu
T
Department of Internal Medicine, National Hospital Organization Kagoshima Medical Center, 8-1 Shiroyama, Kagoshima, 892-0853, Japan.
Mizukami
Kyoko
K
Department of Internal Medicine, National Hospital Organization Kagoshima Medical Center, 8-1 Shiroyama, Kagoshima, 892-0853, Japan.
Suzuki
Sinsuke
S
Department of Hematology and Immunology, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Uozumi
Kimiharu
K
Department of Hematology and Immunology, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Tashiro
Yukie
Y
Department of Pathology, Imakiire General Hospital, 4-16 Shimotatsuo-cho, Kagoshima, 892-8502, Japan.
Arima
Naomichi
N
Department of Hematology and Immunology, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan.
Hanada
Shuichi
S
Department of Internal Medicine, National Hospital Organization Kagoshima Medical Center, 8-1 Shiroyama, Kagoshima, 892-0853, Japan.
D000368:Aged; D019002:CD56 Antigen; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007694:Killer Cells, Natural / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000473:pathology*; D007945:Leukemia, Lymphoid / Q000473:pathology*; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D019002:CD56 Antigen