title: Prevalence of allergic bronchopulmonary aspergillosis in patients with cystic fibrosis in the state of Bahia, Brazil.
abstract: OBJECTIVE
  To determine the prevalence of allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis treated at a referral center in the state of Bahia, Brazil.
  
  
  METHODS
  A cross-sectional study, with prospective data collection, carried out at the Cystic Fibrosis Referral Center of Bahia of the Octavio Mangabeira Specialized Hospital. We evaluated 74 patients diagnosed with cystic fibrosis, older than six years of age, treated between December 9, 2003 and March 7, 2005. We analyzed the following variables: gender, age, forced vital capacity, forced expiratory volume in one second, pharmacodynamic response, chest X-ray findings, facial sinus X-ray findings, wheezing, cultures for Aspergillus spp., total immunoglobulin E (IgE), specific IgE for Aspergillus fumigatus and immediate skin test reactivity to A.fumigatus antigen.
  
  
  RESULTS
  Of the 74 patients, 2 were diagnosed with ABPA. We found total IgE levels > 1,000 IU/mL in 17 (23%), positive immediate skin reactivity to A. fumigatus antigen in 19 (25.7%) and wheezing in 60 (81.1%).
  
  
  CONCLUSIONS
  The prevalence of ABPA was 2.7%. The high levels of total IgE, high incidence of wheezing and high rate of immediate skin test reactivity to A. fumigatus antigen suggest that these patients should be carefully monitored due to their propensity to develop ABPA.
authors.affiliation: Hospital Especializado Octavio Mangabeira, Secretaria de Saúde do Estado da Bahia. anaclaudiaccarneiro@hotmail.com
authors.forename: Ana Cláudia Costa
authors.initials: AC
authors.lastname: Carneiro
authors.forename: Antônio Carlos Moreira
authors.initials: AC
authors.lastname: Lemos
authors.forename: Sérgio Marcos
authors.initials: SM
authors.lastname: Arruda
authors.forename: Maria Angélica Pinheiro Santos
authors.initials: MA
authors.lastname: Santana
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000453:epidemiology* / Q000276:immunology; D001232:Aspergillus fumigatus / Q000276:immunology; D001938:Brazil / Q000453:epidemiology; D002648:Child; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012882:Skin Tests; D055815:Young Adult
chemical_list: D007073:Immunoglobulin E