Accruing preclinical evidence about metabotropic glutamate 5 receptor antagonists as treatments for drug dependence highlights the irreplaceable contributions of animal studies to the discovery of new medications for human disorders.
Markou
Athina
A
Department of Psychiatry, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0603, USA. amarkou@ucsd.edu
D032761:Animal Experimentation; D000818:Animals; D004353:Drug Evaluation, Preclinical; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D051381:Rats; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000235:genetics; D019966:Substance-Related Disorders / Q000188:drug therapy*
D018691:Excitatory Amino Acid Antagonists; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate