title: Edaravone derivatives containing NO-donor functions.
abstract: A new series of polyvalent drugs obtained by joining edaravone with NO-donor moieties is described. All compounds display high antioxidant power together with NO-dependent vasodilator properties. The analysis of a number of molecular descriptors shows that the antioxidant activity, which is tightly linked to the presence of the edaravone substructure, is principally modulated by lipophilicity. These products are potentially useful in the treatment of cardiovascular disorders in which EDRF deficiency and ROS excess are involved.
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Universita degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
authors.forename: Konstantin
authors.initials: K
authors.lastname: Chegaev
authors.forename: Clara
authors.initials: C
authors.lastname: Cena
authors.forename: Marta
authors.initials: M
authors.lastname: Giorgis
authors.forename: Barbara
authors.initials: B
authors.lastname: Rolando
authors.forename: Paolo
authors.initials: P
authors.lastname: Tosco
authors.forename: Massimo
authors.initials: M
authors.lastname: Bertinaria
authors.forename: Roberta
authors.initials: R
authors.lastname: Fruttero
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Carrupt
authors.forename: Alberto
authors.initials: A
authors.lastname: Gasco
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D000983:Antipyrine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000077553:Edaravone; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D000077553:Edaravone; D000983:Antipyrine