Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma.
Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequesters it from proteolytic degradation. This surprising finding further enhances Aurora A's potential as a therapeutic target.
Maris
John M
JM
Division of Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, PA 19104-4318, USA. maris@chop.edu
D000818:Animals; D064127:Aurora Kinases; D002453:Cell Cycle; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*
D016271:Proto-Oncogene Proteins c-myc; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases