title: Steady-state pharmacokinetics of lopinavir/ritonavir in combination with efavirenz in human immunodeficiency virus-infected pediatric patients.
abstract: The pharmacokinetics of lopinavir/ritonavir (LPV/RTV) 300 mg/m twice daily and efavirenz (EFV) 350 mg/m once daily were evaluated in HIV-infected children. The minimum concentrations for LPV contained values above the target range, and the estimated minimum concentrations for EFV contained values below the range. Our data support the current LPV/RTV dose, but EFV 350 mg/m may not be sufficient.
authors.affiliation: The University of Alabama at Birmingham, Birmingham, AL, USA. jennifer.king@ccc.uab.edu
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: King
authors.forename: Edward P
authors.initials: EP
authors.lastname: Acosta
authors.forename: Ram
authors.initials: R
authors.lastname: Yogev
authors.forename: Andrew
authors.initials: A
authors.lastname: Wiznia
authors.forename: Joyce
authors.initials: J
authors.lastname: Kraimer
authors.forename: Bobbie
authors.initials: B
authors.lastname: Graham
authors.forename: Vincent
authors.initials: V
authors.lastname: Carey
authors.forename: Paula
authors.initials: P
authors.lastname: Britto
authors.forename: Patrick
authors.initials: P
authors.lastname: Jean-Philippe
authors.forename: John
authors.initials: J
authors.lastname: Moye
authors.forename: Douglas
authors.initials: D
authors.lastname: Watson
mesh_terms: D000293:Adolescent; D000480:Alkynes; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D048588:Benzoxazines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003521:Cyclopropanes; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D061466:Lopinavir; D008297:Male; D011744:Pyrimidinones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019438:Ritonavir / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D011744:Pyrimidinones; D061466:Lopinavir; C098320:efavirenz; D019438:Ritonavir