Cell-specific loss of kappa-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse.
Jimpy is a murine mutation in myelin proteolipid protein, leading to premature death of oligodendrocytes and severe central nervous system hypomyelination. Jimpy is a bona fide model of human Pelizaeus-Merzbacher disease. This paper describes a severe reduction in expression of kappa-opioid receptors (KOP) in oligodendrocytes of jimpy mice. A cell-specific reduction of >90% is apparent by 5 days of age. Expression is not reduced in neurons, and mu-opioid receptor expression is normal. Mechanism(s) leading to deficient KOP expression in jimpy mice remain unclear. We speculate that loss of KOP may be related to increased [Ca(2+)](i) and premature death of jimpy oligodendrocytes.
Knapp
Pamela E
PE
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA 23298, USA. peknapp@vcu.edu <peknapp@vcu.edu>
Adjan
Valeriya V
VV
Hauser
Kurt F
KF
D000818:Animals; D020013:Calcium Signaling / Q000235:genetics; D016923:Cell Death / Q000235:genetics; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000235:genetics; D020279:Hereditary Central Nervous System Demyelinating Diseases / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D008816:Mice, Jimpy; D009413:Nerve Fibers, Myelinated / Q000378:metabolism* / Q000473:pathology; D009836:Oligodendroglia / Q000378:metabolism* / Q000473:pathology; D020371:Pelizaeus-Merzbacher Disease / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D017473:Receptors, Opioid, kappa / Q000235:genetics / Q000378:metabolism*
D017473:Receptors, Opioid, kappa