[Tongxinluo improves vascular endothelial function in patients with type 2 diabetes].
OBJECTIVE
To investigate the effects of Tongxinluo on vascular endothelial function in patients with type 2 diabetes.


METHODS
A total of 80 patients with type 2 diabetes were recruited and divided into two groups: Tongxinluo therapy group (n = 40) and conventional therapy group (n = 40). Plasma levels of NO, ET, 6-keto-PGF1alpha and TXB2 and diastolic functions of humeral arteries (measured by high-resolution ultrasound) were measured at baseline and 4 weeks later.


RESULTS
The flow-mediated dilation was significantly increased from (8.19 +/- 0.71)% to (12.47 +/- 0.98)% (P < 0.05) in Tongxinluo therapy group after 4 weeks therapy compare to baseline level. Their plasma NO was significantly increased [(47.65 +/- 4.38) pg/ml to (52.91 +/- 4.83) pg/ml, P < 0.001] and plasma ET significantly reduced [(31.23 +/- 2.46) pg/ml to (24.34 +/- 2.46) pg/ml, P < 0.001] post 4 week Tongxinluo therapy. Parameters remained unchanged in the placebo group (P > 0.05) at baseline and 4 weeks later. Non-flow-mediated dilation was unaffected by Tongxinluo therapy.


CONCLUSIONS
Tongxinluo improved the vascular endothelial dependent diastolic function in patients with type 2 diabetes by regulating the balance of plasma NO/ET.
Chen
Hong
H
Department of Cardiology, People's Hospital, Peking University, Beijing 100044, China. chenhong0418@yahoo.com.cn
Yang
Shi-wei
SW
Ren
Jing-yi
JY
Xu
Cheng-bin
CB
Wu
Bei
B
Li
Li-jun
LJ
D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D016232:Endothelins / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood; D016896:Treatment Outcome
D004365:Drugs, Chinese Herbal; D016232:Endothelins; C513941:tongxinluo; D009569:Nitric Oxide