ApoE phenotype is associated with inflammatory markers in middle-aged subjects.
OBJECTIVE
Apolipoprotein (apo) E phenotype has been associated with inflammation markers. The determinants of these associations and the relationship between novel inflammation marker, resistin, and apoE phenotype are studied here.


RESULTS
Middle-aged subjects of the population- based cohort (n = 526) of the OPERA- study were studied. Intima-media thickness (IMT) was measured with carotid ultrasound. The results suggest that, apoE phenotype was a significant independent predictive factor for resistin (p < 0.01) and hsCRP (p < 0.01) levels. The association of ApoE phenotype with hsCRP was seen among the subjects with the normal renal function (p = 0.005). ApoE4 was associated (p < 0.01) with the lowest hsCRP in the lowest IMT quartile while it's relation with the highest resistin levels was evident in the highest IMT quartile.


CONCLUSIONS
ApoE phenotype is an independent determinant of plasma resistin and hsCRP levels. The extent of atherosclerosis and renal function seem to modify the effects of apoE phenotype on inflammatory parameters.
Ukkola
O
O
Department of Internal Medicine, Biocenter Oulu, Oulu, Finland. olavi.ukkola@oulu.fi
Kunnari
A
A
Jokela
M
M
Päivänsalo
M
M
Kesäniemi
Y A
YA
D000328:Adult; D001057:Apolipoproteins E / Q000378:metabolism*; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D052243:Resistin / Q000097:blood*; D017539:Tunica Intima / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D014463:Ultrasonography
D001057:Apolipoproteins E; D015415:Biomarkers; D052243:Resistin; D002097:C-Reactive Protein