Molecular alterations in hereditary and sporadic thyroid and parathyroid diseases.
Thyroid and parathyroid diseases are fairly common and can be either hereditary or sporadic in nature. Tumors and tumor-like processes account for the majority of surgical pathology specimens in both of these endocrine organs. Molecular alterations are well known to occur in both the hereditary and the sporadic settings, and include alterations in tumor suppressor genes and oncogenes. The genetic pathways of tumors of parathyroid and thyroid are beginning to be well understood and are proving to be useful diagnostic, prognostic, and potential therapeutic targets. The molecular alterations in parathyroid and thyroid tumors and tumor-like processes are reviewed, with a focus on the potentially clinically useful diagnostic markers.
Hunt
Jennifer L
JL
Department of Anatomic Pathology, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. huntj2@ccf.org
D000230:Adenocarcinoma / Q000473:pathology; D002277:Carcinoma / Q000145:classification / Q000473:pathology; D002291:Carcinoma, Papillary / Q000145:classification / Q000235:genetics / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics; D018814:Multiple Endocrine Neoplasia Type 2b / Q000235:genetics; D010279:Parathyroid Diseases / Q000145:classification / Q000235:genetics* / Q000473:pathology; D012313:RNA / Q000235:genetics; D013959:Thyroid Diseases / Q000145:classification / Q000235:genetics* / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology
D012313:RNA