Role of central adrenergic structures in the regulation of granulocytopoiesis during cytostatic treatment.
We studied the role of central adrenergic structures in the regulation of granulocytic hemopoietic stem during cytostatic treatment. It was found that brain norepinephrine promoted the decrease in functional activity of adherent mononuclears of the hemopoiesis-inducing environment, cytokine-dependent and alpha-adrenergic mechanisms of regulation of division and maturation of granulomonocytic precursors under conditions of cyclophosphamide treatment. Under conditions of 5-fluorouracil treatment, the effect of the adrenergic system was aimed at the formation of granulocytic and fibroblast-type cell complexes, activation of the production of colony-forming activity by microenvironmental cells, and acceleration of maturation of neutrophilic granulocytes associated with the system of granulocytic CSF and peripheral alpha-adrenergic structures.
Dygai
A M
AM
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Skurikhin
E G
EG
Pershina
O V
OV
Minakova
M Yu
MY
Goldberg
E D
ED
D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D054697:Cytostatic Agents / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects* / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D051379:Mice; D008808:Mice, Inbred CBA; D011941:Receptors, Adrenergic / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology; D013997:Time Factors
D018759:Adrenergic Uptake Inhibitors; D054697:Cytostatic Agents; D011941:Receptors, Adrenergic; D012110:Reserpine; D005472:Fluorouracil