title: Takayasu disease presenting as malignant pyoderma gangrenosum in a child with relapsing polychondritis.
abstract: A 7-year-old Lebanese girl with recently diagnosed relapsing polychondritis had a 1-month history of several painful ulcerations involving her entire body. Skin biopsy was consistent with the diagnosis of pyoderma gangrenosum. She was hospitalized and started on intravenous steroids with partial improvement. During her hospital stay, she developed right wrist drop. Radiologic studies revealed a large aortic aneurysm and an axillary aneurysm compressing the right brachial nerve plexus. Pathology of the resected aortic anyeurism confirmed the diagnosis of Takayasu's arteritis. The patient was started on infliximab therapy with complete resolution of her skin lesions and improvement in hand function.
authors.affiliation: Department of Dermatology, American University of Beirut Medical Center, Beirut, Lebanon. sg03@aub.edu.lb
authors.forename: Samer
authors.initials: S
authors.lastname: Ghosn
authors.forename: Joelle
authors.initials: J
authors.lastname: Malek
authors.forename: Zuhair
authors.initials: Z
authors.lastname: Shbaklo
authors.forename: Mona
authors.initials: M
authors.lastname: Matta
authors.forename: Imad
authors.initials: I
authors.lastname: Uthman
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D017545:Aortic Aneurysm, Thoracic / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D000069285:Infliximab; D011081:Polychondritis, Relapsing / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D013625:Takayasu Arteritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; D000069285:Infliximab