title: Vibrational spectroscopic study of fluticasone propionate.
abstract: Fluticasone propionate is a synthetic glucocorticoid with potent anti-inflammatory activity that has been used effectively in the treatment of chronic asthma. The present work reports a vibrational spectroscopic study of fluticasone propionate and gives proposed molecular assignments on the basis of ab initio calculations using BLYP density functional theory with a 6-31G* basis set and vibrational frequencies predicted within the quasi-harmonic approximation. Several spectral features and band intensities are explained. This study generated a library of information that can be employed to aid the process monitoring of fluticasone propionate.
authors.affiliation: School of Life Sciences, University of Bradford, Bradford, BD7 1DP, UK.
authors.forename: H R H
authors.initials: HR
authors.lastname: Ali
authors.forename: H G M
authors.initials: HG
authors.lastname: Edwards
authors.forename: J
authors.initials: J
authors.lastname: Kendrick
authors.forename: I J
authors.initials: IJ
authors.lastname: Scowen
mesh_terms: D000730:Androstadienes / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D000068298:Fluticasone; D015394:Molecular Structure; D013059:Spectrum Analysis, Raman; D014732:Vibration
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000068298:Fluticasone