A novel one-step synthesis of imidazo[5,1-a]isoquinolines via a tandem Pd-catalyzed alkylation-direct arylation sequence.
A palladium-catalyzed/norbornene-mediated one-step synthesis of highly functionalized imidazoles via a sequential alkyl-aryl and aryl-heteroaryl bond formation is devised. This method provides an efficient route to a wide variety of substituted imidazo[5,1-a]isoquinolines from readily accessible N-bromoalkyl imidazoles and aryl iodides.
Jafarpour
Farnaz
F
School of Chemistry, University College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran. jafarpur@khayam.ut.ac.ir
Ashtiani
Parvaneh T
PT
D000478:Alkylation; D002384:Catalysis; D007093:Imidazoles / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis*; D009636:Norbornanes / Q000737:chemistry; D010165:Palladium / Q000737:chemistry
D007093:Imidazoles; D007546:Isoquinolines; D009636:Norbornanes; D010165:Palladium