[Neuro- and psychotropic activity of N-uronoylamino acids and N-uronoylpeptides].
Peculiarities of rat behavior were studied on a series of experimental stress models after systemic administration of new N-uronoyl derivatives of amino acids. The psychotropic effect was shown to be determined by the nature of the amino acid fragment. N-(l,2:3,4-di-O-isopropylidene-alpha-D-galactopyranuronoyl)-glycylglycine exhibited a more pronounced anxiolytic effect than pyracetam, whereas N-(l,2:3,4-di-O-isopropylidene-alpha-D-galactopyranuronoyl)-glycylglutamic acid is a stronger antidepressant than amitriptyline. Mechanisms of the psychotropic effects of the examined derivatives are discussed.
Ravaeva
M Iu
MIu
Vernadsky Tauric National University, pr. Vernadskogo 4, Simferopol, 95007 Crimea, Ukraine.
Koreniuk
I I
II
Kur'ianov
V O
VO
Chupakhina
T A
TA
Chirva
V Ia
VIa
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D006033:Glycylglycine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy* / Q000503:physiopathology
D018697:Nootropic Agents; D011619:Psychotropic Drugs; D006033:Glycylglycine; D000639:Amitriptyline; D010889:Piracetam