title: Xeroderma pigmentosum: neck lymph node metastasis of a squamous cell carcinoma of the skin treated with cetuximab.
abstract: Xeroderma pigmentosum is a genodermatosis characterized by defects in the DNA nucleotide excision repair pathway, which increases the risk of suffering skin cancers. There is lack of information about the efficacy and toxicity of chemotherapy and radiotherapy in the treatment of these patients. We present the case of a xeroderma pigmentosum patient with a neck node recurrence of a squamous cell skin carcinoma that achieved a good response and survival with cetuximab.
authors.affiliation: Department of Medical Oncology, Catalan Institute of Oncology, Hospital Josep Trueta, AV Francia s/n 17007 Girona, Spain. jrubio@ico.scs.es
authors.forename: Jordi
authors.initials: J
authors.lastname: Rubió Casadevall
authors.forename: Begoña
authors.initials: B
authors.lastname: Graña-Suárez
authors.forename: Xavier
authors.initials: X
authors.lastname: Hernandez-Yagüe
authors.forename: Jordi
authors.initials: J
authors.lastname: Vayreda Ribera
authors.forename: Oscar
authors.initials: O
authors.lastname: Huc Grasa
authors.forename: Joan
authors.initials: J
authors.lastname: Brunet Vidal
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D000068818:Cetuximab; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D009333:Neck; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D014983:Xeroderma Pigmentosum / Q000235:genetics / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D000068818:Cetuximab