title: Disseminated intravascular coagulation during treatment with thalidomide. A case report.
abstract: The treatment with thalidomide is associated with an increased risk of thromboembolic events, in particular when it is combined with chemotherapy or dexamethasone. However, despite this well-documented prothrombotic effect, to our knowledge disseminated intravascular coagulation has never been reported in hematological or oncological patients treated with thalidomide. We report a case of disseminated intravascular coagulation in a patient treated with thalidomide and dexamethasone for advanced, heavily pretreated hormone-resistant prostate cancer in which a relationship with the treatment appears highly likely.
authors.affiliation: Department of Oncology, City Hospital, Rimini, Italy. dtassinari@rimini.com
authors.forename: Davide
authors.initials: D
authors.lastname: Tassinari
authors.forename: Paola
authors.initials: P
authors.lastname: Tombesi
authors.forename: Sergio
authors.initials: S
authors.lastname: Sartori
mesh_terms: D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D013792:Thalidomide / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D020533:Angiogenesis Inhibitors; D018931:Antineoplastic Agents, Hormonal; D013792:Thalidomide; D003907:Dexamethasone