[Effect of shenshuaining dispersible tablets on the levels of NO, NOS, SOD and MDA in kidney of chronic renal failure rats].
OBJECTIVE
To observe the effect of Shenshuaining dispersible tablets on the levels of NO, NOS, SOD and MDA in kidney of chronic renal failure (CRF) rats induced by adenine.


METHODS
Seventy-two Sprague-Dawley rats were randomly divided into 6 groups: normal control group, model control group, Niaoduqing group, Shenshuaining dispersible tablets group(high, middle and low dose). From the second to the sixth group, the rats were prepared for model of CRF by being fed 0.5% adenine. After giving corresponding drugs for 7 weeks, we detected the levels of nitric oxide (NO), total nitric oxide synthase (T-NOS), inducing nitric oxide synthase (iNOS), configuration nitric oxide synthase (cNOS), total superoxide dismutase (SOD), Cu/Zn-SOD and malonaldehyde (MDA) in every rat's kidney tissue.


RESULTS
Compared with normal rats, CRF rats' renal tissue's levels of NO, T-NOS, cNOS, T-SOD and Cu/Zn-SOD markedly decreased. Both the iNOS and MDA contents significantly increased. Shenshuaining dispersible tablets could markedly ameliorate above indexes.


CONCLUSIONS
Shenshuaining dispersible tablets can effectively improve CRF rats' antioxidation effect and reduce damnification of free radical and protect the kidney.
Chen
Ying
Y
Department of Pharmacy, Nanfang Hospital, China.
Xiao
Wei
W
Ma
Yun
Y
Hou
Lian-bing
LB
D000225:Adenine; D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism*; D013607:Tablets
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; C532547:Shenshuaining; D013607:Tablets; D009569:Nitric Oxide; D008315:Malondialdehyde; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D000225:Adenine