Scope of the Suzuki-Miyaura cross-coupling reactions of potassium heteroaryltrifluoroborates.
A wide variety of bench-stable potassium heteroaryltrifluoroborates were prepared, and general reaction conditions were developed for their cross-coupling to aryl and heteroaryl halides. The cross-coupled products were obtained in good to excellent yields. This method represents an efficient and facile installation of heterocyclic building blocks onto preexisting organic substructures.
Molander
Gary A
GA
Roy and Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA. gmolandr@sas.upenn.edu
Canturk
Belgin
B
Kennedy
Lauren E
LE
D001881:Borates / Q000138:chemical synthesis / Q000737:chemistry*; D005663:Furans / Q000138:chemical synthesis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry; D017680:Potassium Compounds / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry
D001881:Borates; D005663:Furans; D006571:Heterocyclic Compounds; D007546:Isoquinolines; D017680:Potassium Compounds; D011725:Pyridines; C098759:fluoroboric acid