IL-1 family in breast cancer: potential interplay with leptin and other adipocytokines.
Obesity is associated with an increased risk of breast cancer. interleukin-1 (IL-1), a pro-inflammatory cytokine secreted by adipose tissue, is involved in breast cancer development. There is also convincing evidence that other adipocytokines including leptin not only have a role in haematopoiesis, reproduction and immunity but are also growth factors in cancer. Therefore, IL-1 family and leptin family are adipocytokines which could represent a major link between obesity and breast cancer progression. This minireview provides insight into recent findings on the prognostic significance of IL-1 and leptin in mammary tumours, and discusses the potential interplay between IL-1 family members and adipocyte-derived hormones in breast cancer.
Perrier
Stéphane
S
Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, UK. s.perrier@dundee.ac.uk
Caldefie-Chézet
Florence
F
Vasson
Marie-Paule
MP
D054392:Adipokines / Q000378:metabolism*; D001943:Breast Neoplasms / Q000209:etiology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D009765:Obesity / Q000150:complications / Q000378:metabolism
D054392:Adipokines; D007375:Interleukin-1; D020738:Leptin