title: Dibenzocyclooctadiene lignans from Kadsura philippinensis.
abstract: Lignans with the dibenzocyclooctadiene skeleton, kadsuphilols I-L, and one C(19)-homolignan, kadsuphilol M, were isolated by chromatographic fractionation of an ethyl acetate extract of the aerial parts of Kadsura philippinensis. Their structures were elucidated through extensive spectroscopic methods, including HRESIMS and 2D NMR experiments (HMQC, COSY and HMBC). The stereochemistry at the chiral centers and the biphenyl moist, were determined using NOESY, as well as analysis of CD spectra, respectively. The relative configuration of heteroclitin J was confirmed by single crystal X-ray crystallographic analysis. The in vitro radical-scavenging activities of these compounds by using DPPH were evaluated.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Sec. 1, Taipei 100, Taiwan. ycshen@ntu.edu.tw
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Shorong-Shii
authors.initials: SS
authors.lastname: Liou
authors.forename: Ashraf Taha
authors.initials: AT
authors.lastname: Khalil
mesh_terms: D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D035261:Plant Components, Aerial / Q000737:chemistry
chemical_list: D017705:Lignans