Spindle assembly: kinesin-5 is in control.
Kinesin-5 is essential in many species for the formation of a bipolar spindle. Although bipolar tetramers were known to crossbridge pairs of microtubules, the mechanism for organizing spindles was unclear. However, new experiments have revealed unique properties of kinesin-5, including some associated with the tail domain, that provide clues as to how spindles are assembled.
Amos
Linda
L
MRC Laboratory of Molecular Biology, Cambridge, UK. laa@mrc-lmb.cam.ac.uk
D000818:Animals; D002455:Cell Division / Q000502:physiology; D016547:Kinesins / Q000737:chemistry / Q000502:physiology*; D018386:Kinetochores / Q000502:physiology; D008870:Microtubules / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D008941:Spindle Apparatus / Q000502:physiology*
D016547:Kinesins