Relationship between oxidized fibrinogen and hemostasis disturbances and endothelial dysfunction in myocardial infarction.
Oxidative modification of fibrinogen in acute myocardial infarction increased 1.3-fold compared to that in CHD and 1.5-fold surpassed that in the control without CHD. Elevated content of oxidized fibrinogen correlated with increased levels of LPO products, von Willebrand factor, and fibrin degradation products, with accelerated leukocyte and platelet aggregation, and reduced content of NO metabolites in the plasma. Independent associations of oxidized fibrinogen with myocardial infarction and typical thrombogenic and hypercoagulation hemostasis disorders and endothelial dysfunctions were revealed.
Ragino
Yu I
YI
Research Institute of Therapy, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. ragino@online.nsk.su
Baum
V A
VA
Polonskaya
Ya V
YV
Sadovski
E V
EV
Baum
S R
SR
Nikitin
Yu P
YP
D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D016022:Case-Control Studies; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D005340:Fibrinogen / Q000378:metabolism*; D006487:Hemostasis / Q000502:physiology*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology; D010084:Oxidation-Reduction; D014652:Vascular Diseases / Q000097:blood* / Q000378:metabolism / Q000503:physiopathology
D005340:Fibrinogen