title: Cranberry phytochemical extract inhibits SGC-7901 cell growth and human tumor xenografts in Balb/c nu/nu mice.
abstract: Cranberry extract possesses potent antioxidant capacity and antiproliferative activity against cancer in vitro and in vivo. The objectives of this study were to determine whether the cranberry extract inhibited proliferation of human gastric cancer SGC-7901 cells and human gastric tumor xenografts in the Balb/c nu/nu mouse. Cranberry extract at doses of 0, 5, 10, 20, and 40 mg/mL significantly inhibited proliferation of SGC-7901 cells, and this suppression was partly attributed to decreased PCNA expression and apoptosis induction. In a human tumor xenograft model, the time of human gastric tumor xenografts in the mouse was delayed in a dose-dependent manner. A dose-response inhibition was also observed in the averages of size, weight, and volume of tumor xenografts in the mouse between the control and cranberry-treated groups. These results demonstrate fresh cranberries to be a chemopreventive reagent.
authors.affiliation: Treatment Center of Oncology, Fourth Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
authors.forename: Luo-Qiang
authors.initials: LQ
authors.lastname: Lin
authors.forename: Bing-Bing
authors.initials: BB
authors.lastname: Song
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Wang
authors.forename: Chun-Peng
authors.initials: CP
authors.lastname: Zhang
authors.forename: Jin-Lu
authors.initials: JL
authors.lastname: Zhao
authors.forename: Jia-Ren
authors.initials: JR
authors.lastname: Liu
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011897:Random Allocation; D029799:Vaccinium macrocarpon / Q000737:chemistry*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D018809:Proliferating Cell Nuclear Antigen