title: PII, the key regulator of nitrogen metabolism in the cyanobacteria.
abstract: PII proteins are a protein family important to signal transduction in bacteria and plants. PII plays a critical role in regulation of carbon and nitrogen metabolism in cyanobacteria. Through conformation change and covalent modification, which are regulated by 2-oxoglutarate, PII interacts with different target proteins in response to changes of cellular energy status and carbon and nitrogen sources in cyanobacteria and regulates cellular metabolism. This article reports recent progress in PII research in cyanobacteria and discusses the mechanism of PII regulation of cellular metabolism.
authors.affiliation: State Key Laboratory of Protein and Plant Genetic Engineering, College of Life Science, Peking University, Beijing, 100871, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: JinDong
authors.initials: J
authors.lastname: Zhao
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000458:Cyanobacteria / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009584:Nitrogen / Q000378:metabolism*; D051922:PII Nitrogen Regulatory Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020836:Protein Structure, Quaternary; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; D051922:PII Nitrogen Regulatory Proteins; D009584:Nitrogen