Relief of radiation-induced oral mucositis in head and neck cancer.
This study was a prospective, randomized clinical trial carried out to explore the efficacy of payayor in the prevention and relief of radiation-induced oral mucositis compared with benzydamine. Sixty patients with head and neck cancer, who have started to receive radiotherapy and met predetermined criteria, were randomly assigned into each group to use assigned products 3 times a day from the first to the last day of radiation. The first group used glycerin payayor, a Thai prepared herbal product, by dripping it into the mouth. Another group rinsed their mouths with benzydamine hydrochloride. The World Health Organization Mucositis Grading System was used to assess oral status every week and 2 weeks after radiation. Comparison of time to the onset, pain, severity, xerostomia, postponement of treatment, satisfaction of the solution, and body weight between the 2 groups was performed by t test. The average time to the onset of oral mucositis in the payayor group was significantly later, and its severity and pain score were less than those of the benzydamine group throughout the study period. Significantly higher satisfaction with the solution and higher body weight at the end of the study were shown in the payayor group. Payayor seemed to be superior to benzydamine for preventing and relieving radiation-induced oral mucositis.
Putwatana
Panwadee
P
Department of Nursing, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Sanmanowong
Phichanee
P
Oonprasertpong
Ladawal
L
Junda
Tiraporn
T
Pitiporn
Supaporn
S
Narkwong
Ladawan
L
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001591:Benzydamine / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008518:Medicine, East Asian Traditional; D008875:Middle Aged; D009730:Nursing Assessment; D008517:Phytotherapy / Q000379:methods*; D011446:Prospective Studies; D011832:Radiation Injuries / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D012720:Severity of Illness Index; D016037:Single-Blind Method; D013280:Stomatitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D013785:Thailand; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D001591:Benzydamine