title: Threat of dengue to blood safety in dengue-endemic countries.
abstract: Dengue, the most common arbovirus infection globally, is transmitted by mosquito vectors. Healthcare-related transmission, including transmission by blood products, has been documented, although the frequency of these occurrences is unknown. Dengue is endemic to Singapore, a city-state in Asia. Using mathematical modeling, we estimated the risk for dengue-infected blood transfusions in Singapore in 2005 to be 1.625-6/10,000 blood transfusions, assuming a ratio of asymptomatic to symptomatic infections of 2:1 to 10:1. However, the level of viremia required to cause clinical dengue cases is person-dependent and unknown. Further studies are needed to establish the magnitude of the threat that dengue poses to blood safety in countries where it is endemic. It will then be possible after this information is obtained to assess whether screening is feasible and to identify approaches that are most cost-effective on the basis of characteristics of local populations and seasonality of dengue.
authors.affiliation: Department of Medicine, National University Singapore, Singapore. epvws@pacific.net.sg
authors.forename: Annelies
authors.initials: A
authors.lastname: Wilder-Smith
authors.forename: Lin H
authors.initials: LH
authors.lastname: Chen
authors.forename: Eduardo
authors.initials: E
authors.lastname: Massad
authors.forename: Mary E
authors.initials: ME
authors.lastname: Wilson
mesh_terms: D000293:Adolescent; D000328:Adult; D001769:Blood / Q000821:virology; D003715:Dengue / Q000175:diagnosis / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification*; D019353:Endemic Diseases; D006801:Humans; D008403:Mass Screening; D008954:Models, Biological; D018570:Risk Assessment; D012846:Singapore / Q000453:epidemiology; D065227:Transfusion Reaction; D055815:Young Adult