Chronic kidney disease with three cases of oxalate-like nephrosis in Ragdoll cats.
Two unrelated Ragdoll cat mothers in Norway were found dead from renal disease. The histopathology was consistent with oxalate nephrosis with chronic or acute-on-chronic underlying kidney disease. Both cats had offspring and relatives with signs of urinary tract disease, including a kitten dead with urethral gravel. Eleven living Ragdoll cats, including nine relatives of the dead cats and the male father of a litter with similarly affected animals, were tested for primary hyperoxaluria (PH) type 1 and 2 by urine oxalate and liver enzyme analysis. Renal ultrasound revealed abnormalities in five living cats. One of these was azotaemic at the time of examination and developed terminal kidney disease 9 months later. A diagnosis of PH was excluded in 11 cats tested. The inheritance and aetiological background of the renal disease present in the breed remains unresolved at this point in time.
Heiene
Reidun
R
Department of Companion Animal Clinical Sciences, Norwegian School of Veterinary Science, N-0033 Oslo, Norway. reidun.heiene@veths.no
Rumsby
Gill
G
Ziener
Martine
M
Dahl
Stein A
SA
Tims
Christopher
C
Teige
Jon
J
Ottesen
Nina
N
D000818:Animals; D002371:Cat Diseases / Q000000981:diagnostic imaging / Q000235:genetics / Q000473:pathology* / Q000652:urine; D002415:Cats; D005260:Female; D006960:Hyperoxaluria, Primary / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D008297:Male; D009401:Nephrosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology / Q000652:urine / Q000662:veterinary*; D009664:Norway; D010070:Oxalates / Q000652:urine; D014463:Ultrasonography
D010070:Oxalates