title: Sarcoplasmic reticulum-mitochondrial symbiosis: bidirectional signaling in skeletal muscle.
abstract: In mammalian skeletal muscle, an intimate association between the sarcoplasmic reticulum (SR) and mitochondria results in a symbiotic and privileged bidirectional communication between these organelles. Orthograde signaling reflects SR calcium (Ca) release stimulating mitochondrial adenosine triphosphate production via excitation-metabolism coupling. Retrograde signaling involves mitochondrial inhibition of local SR Ca release by controlling the redox environment of the Ca release unit.
authors.affiliation: Department of Pharmacology and Physiology, University of Rochester, Rochester, NY 14642, USA.
authors.forename: Ann E
authors.initials: AE
authors.lastname: Rossi
authors.forename: Simona
authors.initials: S
authors.lastname: Boncompagni
authors.forename: Robert T
authors.initials: RT
authors.lastname: Dirksen
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D020013:Calcium Signaling; D008928:Mitochondria / Q000378:metabolism*; D009119:Muscle Contraction; D018763:Muscle Fatigue; D018482:Muscle, Skeletal / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
chemical_list: D000255:Adenosine Triphosphate