title: De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.
abstract: Mouse blastocyst stage embryo stained for histone H3 lysine-27 trimethylation (red) and DNA (blue). H3K27me3 marks the inactive X chromosome. The study by Chiba et al. in this issue suggests that de novo DNA methyltransferases are dispensable for setting the imprint on the maternally-derived X chromsome in growing oocytes. See Chiba et al. in this issue.
authors.affiliation: Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, 1111 Yata, Mishima, Japan.
authors.forename: Hatsune
authors.initials: H
authors.lastname: Chiba
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Hirasawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kaneda
authors.forename: Yuko
authors.initials: Y
authors.lastname: Amakawa
authors.forename: En
authors.initials: E
authors.lastname: Li
authors.forename: Takashi
authors.initials: T
authors.lastname: Sado
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D019175:DNA Methylation / Q000235:genetics*; D018392:Genomic Imprinting; D051379:Mice; D009865:Oocytes / Q000502:physiology*; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism*