[The involvement of the renin-angiotensin system (RAS) in cancerogenesis].
The family of angiotensin peptides was connected mainly with cardiovascular system and water-electrolic balance. During the last decade it has been established that, apart from its classical actions, Ang II is involved in the regulation of cell growth, proliferation, cell migration, apoptosis, inflammation, differentiation, angiogenesis and gene expression, which suggests that this peptide might also play role in a cancer. This review focuses on the role of the RAS in tumors and present clinical potential of manipulating the angiotensin system as a novel and promising strategy for cancer treatment.
Domińska
Kamila
K
Departament of Comparative Endocrinology, Medical University of Lodz, 3 Sterlinga St., 91-425 Lodz, Poland. kamila-107107@wp.pl
Lachowicz-Ochedalska
Agnieszka
A
D000818:Animals; D017209:Apoptosis; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology* / Q000628:therapy*; D009389:Neovascularization, Pathologic; D018384:Oxidative Stress; D010447:Peptide Hydrolases / Q000378:metabolism; D010455:Peptides / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000378:metabolism; D012084:Renin-Angiotensin System
D010455:Peptides; D011945:Receptors, Angiotensin; D010447:Peptide Hydrolases