title: Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae).
abstract: Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a public health problem in many countries particularly in Africa. The present study was designed to evaluate the antisickling properties of three isomeric divanilloylquinic acids (3,4-O-divanilloylquinic acid or burkinabin A; 3,5-O-divanilloylquinic acid or burkinabin B and 4,5-O-divanilloylquinic acid or burkinabin C) identified previously by LC/MS/NMR analysis in the root bark of F. zanthoxyloides [Ouattara et al., 2004. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65, 1145-1151]. The three isomers showed interesting antisickling properties which increased from burkinabins A to C.
authors.affiliation: Institut de Recherche en Sciences de la Santé (IRSS), Département Médecine Pharmacopée Traditionnelle, Pharmacie 03 BP7192 Ouagadougou 03, Burkina Faso.
authors.forename: B
authors.initials: B
authors.lastname: Ouattara
authors.forename: O
authors.initials: O
authors.lastname: Jansen
authors.forename: L
authors.initials: L
authors.lastname: Angenot
authors.forename: I P
authors.initials: IP
authors.lastname: Guissou
authors.forename: M
authors.initials: M
authors.lastname: Frédérich
authors.forename: P
authors.initials: P
authors.lastname: Fondu
authors.forename: M
authors.initials: M
authors.lastname: Tits
mesh_terms: D000349:Africa; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000986:Antisickling Agents / Q000627:therapeutic use*; D004205:Cromolyn Sodium / Q000627:therapeutic use; D006801:Humans; D007536:Isomerism; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D032106:Zanthoxylum / Q000737:chemistry
chemical_list: D000986:Antisickling Agents; D010936:Plant Extracts; C539924:burkinabin A; C539925:burkinabin B; C539926:burkinabin C; D011801:Quinic Acid; D014641:Vanillic Acid; D004205:Cromolyn Sodium