title: Japonicones A-D, bioactive dimeric sesquiterpenes from Inula japonica Thunb.
abstract: Four new dimeric sesquiterpene lactones japonicones A-D (1-4), comprised by eudesmane and guaiane sesquiterpenes, were isolated from the aerial part of Inula japonica Thunb. The structures and stereochemistry of 1-4 were elucidated by use of 2D NMR spectroscopic techniques, X-ray crystallography and modified Mosher method. Japonicone A (1) showed the most potent cytotoxicities against four tumor cell lines, A549, LOVO, CEM and MDA-MB-435.
authors.affiliation: School of Pharmacy, Shanghai Jiao Tong University, MinHang DongChuan Rd800, Shanghai 200240, PR China.
authors.forename: Jiang Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Hui Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Jian Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Xiao Jia
authors.initials: XJ
authors.lastname: Hu
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Shi Kai
authors.initials: SK
authors.lastname: Yan
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray / Q000379:methods; D019281:Dimerization; D006801:Humans; D038143:Inula / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry*; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry*; D013237:Stereoisomerism; D013778:Tetrazolium Salts / Q000737:chemistry; D013844:Thiazoles / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D045789:Sesquiterpenes, Guaiane; D013778:Tetrazolium Salts; D013844:Thiazoles; C585467:japonicone A; C022616:thiazolyl blue