The L-type Ca(2+) channel as a potential mediator of pathology during alterations in cellular redox state.
The L-type Ca(2+) channel is the main route for calcium influx into cardiac myocytes and an important determinant of calcium homeostasis. There is now considerable evidence that the function of the L-type Ca(2+) channel is influenced by the cell's redox state. Reactive oxygen species such as hydrogen peroxide and superoxide can regulate biological function by directly altering the thiol redox state of proteins. Under conditions where cellular redox state varies, L-type Ca(2+) channel function and diastolic calcium levels can be significantly altered. This article will present the evidence for alterations in L-type Ca(2+) channel function by reactive oxygen species and the potential role for the channel in development of acute electrophysiological instability or chronic pathological remodelling under conditions of persistent oxidative stress.
Hool
Livia C
LC
School of Biomedical, Biomolecular and Chemical Sciences and The Western Australian Institute for Medical Research, The University of Western Australia, Crawley, Western Australia, Australia. lhool@cyllene.uwa.edu.au
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000378:metabolism* / Q000473:pathology; D002118:Calcium / Q000378:metabolism*; D020746:Calcium Channels, L-Type / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism* / Q000473:pathology; D010084:Oxidation-Reduction; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D020257:Ventricular Remodeling
D020746:Calcium Channels, L-Type; D013438:Sulfhydryl Compounds; D013481:Superoxides; D006861:Hydrogen Peroxide; D002118:Calcium