Facile synthesis and anti-tumor cell activity of Se-containing nucleosides.
Many organic compounds containing selenium have shown anticancer effects and some have been used in chemoprevention of cancers and other diseases. Though Se-containing amino acids are generally used for these purposes, the natural nucleosides may also be used as Se-carriers for these important applications. Therefore, we describe here the convenient synthesis of the new 3'-MeSe-thymidine nucleoside and the other uridine and thymidine derivatives modified with MeSe at the 2' and 5' positions, and report their anti-tumor activity against prostate cancer cell lines. Our work demonstrates for the first time anticancer activity of the methylseleno nucleosides.
Lin
Lina
L
Department of Chemistry, Georgia State University, Atlanta, Georgia 30303, USA.
Sheng
Jia
J
Momin
Razin K
RK
Du
Quan
Q
Huang
Zhen
Z
D045744:Cell Line, Tumor; D002478:Cells, Cultured; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012645:Selenomethionine / Q000138:chemical synthesis / Q000494:pharmacology*; D013936:Thymidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
D012645:Selenomethionine; D013936:Thymidine; D003857:Deoxyuridine