In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms.
The in vitro schistosomicidal activity of curcumin (doses ranging from 5 to 100 microM) was carried out against Schistosoma mansoni adult worms. Curcumin (at 50 and 100 microM) caused death of all worms. When tested at the doses of 5 and 20 microM, it decreased the worm viability in comparison with negative (Roswell Memorial Park Institute (RPMI) 1640 medium alone or RPMI 1640 medium with 10% dimethyl sulfoxide) and positive (heat-killed worms at 56 degrees C or praziquantel 10 microM) control groups. All pairs of coupled adult worms were separated into individual male and female by the action of curcumin at the doses of 20 to 100 microM. When tested at 5 and 10 microM, curcumin reduced egg production by 50% in comparison with the positive control group. It is the first time that the schistosomicidal activity has been reported for curcumin.
Magalhães
Lizandra G
LG
Departamento de Bioquímica e Imunologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, 14049-900, Ribeirão Preto, São Paulo, Brazil.
Machado
Carla Botelho
CB
Morais
Enyara Rezende
ER
Moreira
Erika Bueno de Carvalho
EB
Soares
Cláudia Sossai
CS
da Silva
Sérgio Henrique
SH
Da Silva Filho
Ademar A
AA
Rodrigues
Vanderlei
V
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology*; D005260:Female; D008297:Male; D033661:Oocysts / Q000187:drug effects; D012550:Schistosoma mansoni / Q000187:drug effects*; D016019:Survival Analysis
D000981:Antiprotozoal Agents; D003474:Curcumin