title: Clinical characteristics of lower bowel perforation with chronic renal failure.
abstract: OBJECTIVE
  This study was conducted to evaluate the clinical characteristics of lower bowel perforation (LBP) with chronic renal failure (CRF).
  
  
  METHODS
  In 58 patients with LBP, clinical variables, such as findings of clinical examinations, operative findings, and results of laboratory blood tests were examined as possible prognostic factors for in-hospital death, and compared between CRF and non-CRF groups.
  
  
  RESULTS
  Of the 58 patients, 21 died during hospitalization (mortality rate, 36.2%). The mortality rate of patients with CRF was 54.2%. In the patients with LBP, the following variables were significantly correlated with in-hospital death (p<0.05): hypotension, CRF, fecal peritonitis, and low white blood cell (WBC) count, and low albumin and base excess (BE) levels. The odds ratios of in-hospital death were highest for a WBC count of 9000/mm3 and a BE of -3mEqL. Between the CRF and non-CRF groups, significant differences in the rates of age < 70 years, fecal peritonitis, in-hospital death, and low WBC count and BE were found (p<0.05).
  
  
  CONCLUSIONS
  We identified prognostic factors of LBP and demonstrated the clinical characteristics of LBP with CRF. These results indicate that patients who have LBP with CRF tend to have immediate sepsis and a poor prognosis.
authors.affiliation: Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, Fukuoka 811-1395, Japan. takaakimas@ybb.ne.jp
authors.forename: Taka-aki
authors.initials: TA
authors.lastname: Masuda
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Iso
authors.forename: Satoru
authors.initials: S
authors.lastname: Funahashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tateishi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Shima
authors.forename: Akinori
authors.initials: A
authors.lastname: Kido
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Gohya
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Masuda
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000401:mortality*; D007676:Kidney Failure, Chronic / Q000150:complications*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies