Vibrational spectroscopic study of fluticasone propionate.
Fluticasone propionate is a synthetic glucocorticoid with potent anti-inflammatory activity that has been used effectively in the treatment of chronic asthma. The present work reports a vibrational spectroscopic study of fluticasone propionate and gives proposed molecular assignments on the basis of ab initio calculations using BLYP density functional theory with a 6-31G* basis set and vibrational frequencies predicted within the quasi-harmonic approximation. Several spectral features and band intensities are explained. This study generated a library of information that can be employed to aid the process monitoring of fluticasone propionate.
Ali
H R H
HR
School of Life Sciences, University of Bradford, Bradford, BD7 1DP, UK.
Edwards
H G M
HG
Kendrick
J
J
Scowen
I J
IJ
D000730:Androstadienes / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry*; D000068298:Fluticasone; D015394:Molecular Structure; D013059:Spectrum Analysis, Raman; D014732:Vibration
D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000068298:Fluticasone