title: Common variations in 4p locus are related to male completed suicide.
abstract: Suicidal behavior is a multifactorial phenomenon, with a significant genetic predisposition. To assess the contribution of genes in the 4p region to suicide risk, we genotyped 36 single nucleotide polymorphisms from a 49Mb region on the chromosome arm 4p11-16 in a total of 288 male suicide victims and 327 healthy male volunteers. The nonsynonymous variants rs1383180 in EVC gene, rs6811863 in TBC1D1 gene, rs362272 in HTT gene, and rs734312 in WFS1 gene were associated to the male completed suicide. However, only EVC polymorphism remained significant after correcting for multiple comparisons (P < .05 after 10 K permutations). The function of these genes is not clear yet. WFS1 and HTT are related to the unfolded protein response and endoplasmic reticulum stress, and TBC1D1 is a GTPase activator. EVC is a protein with transmembrane and leucine zipper domains, its function has not been elucidated yet. Further studies are required in order to reveal the role of these four polymorphisms in the pathoetiology of suicide.
authors.affiliation: Institute of Physiology, Tartu University, Ravila 19, Tartu, 50411, Estonia. anne.must@ut.ee
authors.forename: Anne
authors.initials: A
authors.lastname: Must
authors.forename: Sulev
authors.initials: S
authors.lastname: Kõks
authors.forename: Eero
authors.initials: E
authors.lastname: Vasar
authors.forename: Gunnar
authors.initials: G
authors.lastname: Tasa
authors.forename: Aavo
authors.initials: A
authors.lastname: Lang
authors.forename: Eduard
authors.initials: E
authors.lastname: Maron
authors.forename: Marika
authors.initials: M
authors.lastname: Väli
mesh_terms: D000293:Adolescent; D000328:Adult; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013405:Suicide; D055815:Young Adult
chemical_list: D005819:Genetic Markers