title: Transmission and long-term stability of compensated CD8 escape mutations.
abstract: Human immunodeficiency virus effectively evades CD8(+) T-cell responses through the development of CD8 escape mutations. Recent reports documenting reversion of transmitted mutations and the impact of specific escape mutations upon viral replication suggest that complex forces limit the accumulation of CD8 escape mutations at the population level. However, the presence of compensatory mutations capable of alleviating the impact of CD8 escape mutations on replication capacity may enable their persistence in an HLA-mismatched host. Herein, we illustrate the long-term stability of stereotypic escape mutations in the immunodominant HLA-B27-restricted epitope KK10 in p24/Gag following transmission when accompanied by a specific compensatory mutation.
authors.affiliation: Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Arne
authors.initials: A
authors.lastname: Schneidewind
authors.forename: Zabrina L
authors.initials: ZL
authors.lastname: Brumme
authors.forename: Chanson J
authors.initials: CJ
authors.lastname: Brumme
authors.forename: Karen A
authors.initials: KA
authors.lastname: Power
authors.forename: Laura L
authors.initials: LL
authors.lastname: Reyor
authors.forename: Kristin
authors.initials: K
authors.lastname: O'Sullivan
authors.forename: Adrianne
authors.initials: A
authors.lastname: Gladden
authors.forename: Ursula
authors.initials: U
authors.lastname: Hempel
authors.forename: Thomas
authors.initials: T
authors.lastname: Kuntzen
authors.forename: Yaoyu E
authors.initials: YE
authors.lastname: Wang
authors.forename: Cesar
authors.initials: C
authors.lastname: Oniangue-Ndza
authors.forename: Heiko
authors.initials: H
authors.lastname: Jessen
authors.forename: Martin
authors.initials: M
authors.lastname: Markowitz
authors.forename: Eric S
authors.initials: ES
authors.lastname: Rosenberg
authors.forename: Rafick-Pierre
authors.initials: RP
authors.lastname: Sékaly
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Kelleher
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Walker
authors.forename: Todd M
authors.initials: TM
authors.lastname: Allen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D018984:Epitopes, T-Lymphocyte / Q000235:genetics* / Q000276:immunology*; D006678:HIV / Q000235:genetics / Q000254:growth & development* / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000235:genetics; D006801:Humans; D008969:Molecular Sequence Data; D020125:Mutation, Missense / Q000276:immunology*; D014779:Virus Replication
chemical_list: D018984:Epitopes, T-Lymphocyte; D016655:HIV Core Protein p24