title: Oral mucosal cell response to Candida albicans in transgenic mice expressing HIV-1.
abstract: Controlled studies on the immunopathogenesis of mucosal candidiasis in HIV infection have been hampered by the lack of a relevant animal model. We have previously reported that oral Candida infection in CD4C/HIV transgenic mice expressing gene products of HIV-1 in immune cells and developing an AIDS-like disease closely mimics oropharyngeal candidiasis in human HIV infection. The role of defective dendritic cells and CD4+ T cells in impaired induction of protective immunity and in the phenotype of chronic oral carriage of C. albicans can now be investigated under controlled conditions in these transgenic mice.
authors.affiliation: Department of Microbiology and Immunology, Sainte-Justine Hospital and University of Montreal, Montreal, Quebec, Canada.
authors.forename: Louis
authors.initials: L
authors.lastname: de Repentigny
authors.forename: Daniel
authors.initials: D
authors.lastname: Lewandowski
authors.forename: Francine
authors.initials: F
authors.lastname: Aumont
authors.forename: Zaher
authors.initials: Z
authors.lastname: Hanna
authors.forename: Paul
authors.initials: P
authors.lastname: Jolicoeur
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000209:etiology* / Q000276:immunology; D000818:Animals; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000209:etiology* / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D017931:DNA Primers / Q000235:genetics; D003713:Dendritic Cells / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005434:Flow Cytometry; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity*; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009061:Mouth Mucosa / Q000276:immunology* / Q000382:microbiology*
chemical_list: D016207:Cytokines; D017931:DNA Primers