Nonlinear effects in asymmetric catalysis.
There is a need for the preparation of enantiomerically pure compounds for various applications. An efficient approach to achieve this goal is asymmetric catalysis. The chiral catalyst is usually prepared from a chiral auxiliary, which itself is derived from a natural product or by resolution of a racemic precursor. The use of non-enantiopure chiral auxiliaries in asymmetric catalysis seems unattractive to preparative chemists, since the anticipated enantiomeric excess (ee) of the reaction product should be proportional to the ee value of the chiral auxiliary (linearity). In fact, some deviation from linearity may arise. Such nonlinear effects can be rich in mechanistic information and can be synthetically useful (asymmetric amplification). This Review documents the advances made during the last decade in the use of nonlinear effects in the area of organometallic and organic catalysis.
Satyanarayana
Tummanapalli
T
Laboratoire de Catalyse Moléculaire, Institut de Chimie Moléculaire et des Matériaux d'Orsay (CNRS, UMR 8182) Université Paris-Sud, 91405, Orsay, France.
Abraham
Susan
S
Kagan
Henri B
HB
D002384:Catalysis; D008024:Ligands; D017711:Nonlinear Dynamics; D009942:Organometallic Compounds / Q000737:chemistry; D012995:Solubility; D013237:Stereoisomerism
D008024:Ligands; D009942:Organometallic Compounds