[The astacin family of metalloproteinases].
The review deals with the properties of astacin family of zinc-dependent metalloproteinases. One of the remarkable features of these enzymes is their ability to cleave peptidyl-arylamides, which is not typical to other metalloproteinases. Special attention is paid to physiological functions of the astacins and to the influence of domain composition and posttranslational modifications on the activity and stability of these enzymes.
Semenova
S A
SA
Rudenskaia
G N
GN
D000626:Aminopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D004795:Enzyme Stability / Q000502:physiology; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D017434:Protein Structure, Tertiary / Q000502:physiology; D015032:Zinc / Q000737:chemistry / Q000378:metabolism*
D000626:Aminopeptidases; D008666:Metalloendopeptidases; C071288:astacin; D015032:Zinc