title: Synthesis and antibacterial property of quinolines with potent DNA gyrase activity.
abstract: Synthesis of a series of novel tetrahydroquinoline annulated heterocycles has been accomplished by intramolecular imino and bisimino Diels-Alder reaction. These compounds were evaluated for their antibacterial activity. All the synthetic compounds, exhibited good antibacterial activity against microorganisms of which one of them 7 was found to be as active as the antibiotic ciplofloxacin and is found to have MIC value of 2.5 mg/mL against Escherichia coli.
authors.affiliation: Department of Organic Chemistry, Guindy Campus, University of Madras, Chennai 600025, India.
authors.forename: Ekambaram
authors.initials: E
authors.lastname: Ramesh
authors.forename: Rathna Durga R S
authors.initials: RD
authors.lastname: Manian
authors.forename: Ragavachary
authors.initials: R
authors.lastname: Raghunathan
authors.forename: Shilpakala
authors.initials: S
authors.lastname: Sainath
authors.forename: Malathi
authors.initials: M
authors.lastname: Raghunathan
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002939:Ciprofloxacin; D004926:Escherichia coli / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D059005:Topoisomerase II Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; D011804:Quinolines; D059005:Topoisomerase II Inhibitors; D002939:Ciprofloxacin