Comparative clinicopathological study of intraoral sebaceous hyperplasia and sebaceous adenoma.
OBJECTIVE
The objective of this study was to compare the clinicopathological features of oral sebaceous hyperplasia and sebaceous adenoma.


METHODS
Clinical data, microscopical characteristics, and ki-67 immunoexpression were comparatively analyzed on 2 intraoral sebaceous adenomas, 6 intraoral sebaceous hyperplasias, and 21 normal intraoral sebaceous glands.


RESULTS
Clinically, sebaceous glands presented as multiple separated papules, sebaceous hyperplasias as a single enlarged papule, and sebaceous adenoma as a well-defined nodule. Microscopically, sebaceous adenoma presented an increased number of lobules, smaller lobules, and a greater number of germinative/squamous cells. Sebaceous hyperplasia also had an increased number of lobules and fewer number of germinative/squamous cells, as compared to normal oral sebaceous glands. Ki-67 expression was seen only in germinative cells and counts were higher in sebaceous adenomas followed by hyperplasias and normal glands.


CONCLUSIONS
Sebaceous hyperplasias and adenomas showed different clinical, microscopic, and proliferative characteristics, suggesting the usefulness of the studied criteria on diagnosis of these uncommon oral lesions.
Azevedo
Rebeca Souza
RS
Department of Oral Diagnosis, Piracicaba Dental School, State University of Campinas, Piracicaba/SP, Brazil.
Almeida
Oslei Paes
OP
Netto
Juliana Noronha Santos
JN
Miranda
Aguida Maria Menezes Aguiar
AM
Santos
Teresa Cristina Ribeiro Bartholomeu
TC
Della Coletta
Ricardo
R
Lopes
Márcio Ajudarte
MA
Pires
Fábio Ramôa
FR
D000236:Adenoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D012625:Sebaceous Gland Diseases / Q000473:pathology*; D012626:Sebaceous Gland Neoplasms / Q000473:pathology*; D012627:Sebaceous Glands / Q000473:pathology*; D055815:Young Adult
D019394:Ki-67 Antigen