Factors contributing to the development of restless legs syndrome in patients with Parkinson disease.
Although restless legs syndrome (RLS) commonly accompanies Parkinson disease (PD), the mechanism of RLS development in PD is still unclear. We investigated the prevalence of RLS in Korean patients with PD, and the possible contributing factors to the development of RLS in those patients. Four hundred forty-seven consecutive patients with PD were interviewed and examined. Among them, 73 patients (16.3%) were diagnosed with RLS. PD patients with RLS had a longer duration of PD symptoms, more severe PD disability, a greater degree of cognitive decline, and a longer duration of antiparkinson therapy than those without RLS. Multivariate logistic regression analysis revealed that the duration of antiparkinson therapy was the most significant factor contributing to the development of RLS in patients with PD. The present results support a higher prevalence of RLS in patients with PD and suggest that long-term antiparkinson therapy, rather than PD itself, may contribute to the development of RLS.
Lee
Ji E
JE
Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul 120-752, Korea.
Shin
Hae-Won
HW
Kim
Kyung S
KS
Sohn
Young H
YH
D000368:Aged; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000453:epidemiology*; D015995:Prevalence; D012148:Restless Legs Syndrome / Q000175:diagnosis* / Q000453:epidemiology*; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires