title: Correlation analysis of HOX, ErbB and IGFBP family gene expression in ovarian cancer.
abstract: Utilizing microarray gene expression data in cancer research possesses the ability to identify deregulated cellular pathways involved in malignant development. This study investigated the relationships of three gene families, HOX, ErbB and IGFBP, with regard to the development of ovarian cancer. These families were of interest because of similar chromosomal locations and their deregulated expression in ovarian cancer. Higher level statistics were used to differentially analyze microarray data in 65 ovarian samples to assess correlation and relationships among the gene families of interest. Fifteen genes in the three families were found to be significantly deregulated. Thirty-eight significant correlations were found within and between the genes of interest. Our data indicates that the significantly modeled relationships between HOX, ErbB and IGFBP gene pairs could provide insight into the underlying biological mechanisms in ovarian cancer.
authors.affiliation: Cannon Research Center, Molecular Biology Core Facility, Carolinas Medical Center, Charlotte, NC 28203, USA. zahra.mostafavi@carolinashealthcare.org
authors.forename: Zahra
authors.initials: Z
authors.lastname: Bahrani-Mostafavi
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Tickle
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Kristen E
authors.initials: KE
authors.lastname: Bennett
authors.forename: Judith C
authors.initials: JC
authors.lastname: Vachris
authors.forename: Melanie D
authors.initials: MD
authors.lastname: Spencer
authors.forename: M Taghi
authors.initials: MT
authors.lastname: Mostafavi
authors.forename: David L
authors.initials: DL
authors.lastname: Tait
mesh_terms: D066246:ErbB Receptors / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics*; D005810:Multigene Family; D020411:Oligonucleotide Array Sequence Analysis; D010051:Ovarian Neoplasms / Q000235:genetics*; D012334:RNA, Neoplasm / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D018398:Homeodomain Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D012334:RNA, Neoplasm; C512478:EGFR protein, human; D066246:ErbB Receptors