[Study on the progress of the mechanism of TGF-beta in the scarring and the effect of TCM].
Transforming growth factor (TGF-beta) plays a central role in wound healing and scarring. TGF-beta is a member of cytokine family, involving cell proliferation, migration, differentiation and apoptosis, which subsequently trigger extracellular matrix (ECM) deposite and collagen overproduction. A number of regulators of TGF-beta expression bave been identified, including Decorin CTGF, etc. TCM can reduced later scarring, and it accelerates wound healing. TCM can reduce the expression of TGF-beta, resistance of fibrosis, so that lighten the development of scar. This article reviewed the mechanism of TGF-beta in the scarring and TCM can decrease the development of scar effected by TGF-beta.
Wang
Rong-Guo
RG
School of Acupuncture, Moxibustion & Tuina, Beijing University of Chinese Medicine, Beijing 100029, China. wgls2001@163.com
Zhou
Wei
W
Zhang
Yong-Dong
YD
D000818:Animals; D002921:Cicatrix / Q000188:drug therapy / Q000378:metabolism*; D005355:Fibrosis / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D008516:Medicine, Chinese Traditional; D016212:Transforming Growth Factor beta / Q000378:metabolism*
D016212:Transforming Growth Factor beta