title: Dynamic changes of germinal vesicle chromatin configuration and transcriptional activity during maturation of rabbit follicles.
abstract: Dynamic changes in configuration of germinal vesicle (GV) chromatin and their effects on oocyte transcriptional activity and developmental competence were studied in rabbit oocytes. The results indicated that global condensation of GV chromatin, rather than the formation of a perinucleolar ring, would better reflect the global transcriptional repression and developmental competence of oocytes. Gonadotropins, by promoting large-scale chromatin remodeling, regulate oocyte transcriptional activity and developmental competence.
authors.affiliation: College of Animal Science & Veterinary Medicine, Shandong Agricultural University, Tai-an City, People's Republic of China.
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Hong-Shu
authors.initials: HS
authors.lastname: Sui
authors.forename: Yong
authors.initials: Y
authors.lastname: Liu
authors.forename: De-Qiang
authors.initials: DQ
authors.lastname: Miao
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Lu
authors.forename: Bo
authors.initials: B
authors.lastname: Liang
authors.forename: Jing-He
authors.initials: JH
authors.lastname: Tan
mesh_terms: D000818:Animals; D002843:Chromatin / Q000502:physiology*; D042002:Chromatin Assembly and Disassembly / Q000502:physiology*; D054885:Cumulus Cells / Q000502:physiology; D005260:Female; D005498:Follicular Phase / Q000502:physiology; D006062:Gonadotropins / Q000502:physiology; D023421:Models, Animal; D009865:Oocytes / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology; D006080:Ovarian Follicle / Q000254:growth & development* / Q000502:physiology; D011817:Rabbits; D014158:Transcription, Genetic / Q000502:physiology*
chemical_list: D002843:Chromatin; D006062:Gonadotropins