[Factors associated plasma B type natriuretic peptide and N-terminal pro-B-type natriuretic peptide levels].
OBJECTIVE
To identify factors closely associated with plasma B type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels.


METHODS
A total of 1983 people (mean 66 years-old and 694 male) underwent annual health check-up in 2006 in Okuizumo district were included in this study. Blood pressure, electrocardiogram, conventional blood examination, plasma BNP and NT-proBNP were measured.


RESULTS
BNP is positively correlated with NT-proBNP (r = 0.89, P < 0.01). Multiple regression analysis showed that age, Hb, pulse rate, SBP, TC, gender, TG and creatinine were significantly related to BNP and age, creatinine, Hb, gender, TG, TC, SBP, pulse rate were significantly related to NT-proBNP. NT-proBNP was more easily affected by renal function changes and BNP was more easily affected by autonomic nervous system changes. Both BNP and NT-proBNP significantly increased in proportion to SBP and age. NT-proBNP and BNP were significantly higher in females compared with males (all P < 0.05). NT-proBNP and BNP were also negatively correlated with abdominal circumference (all P < 0.05).


CONCLUSIONS
In this study population, NT-proBNP and BNP were closely associated with age, blood pressure, creatinine, pulse rate, lipid levels, gender and abdominal circumferences.
Chen
Yuan
Y
Department of Cardiology, the Second Affiliated Hospital of Ningxia Medical College, Yinchuan 750001, China.
Yao
Cheng-Li
CL
Shimada
Toshio
T
D000367:Age Factors; D000368:Aged; D001794:Blood Pressure; D005260:Female; D006339:Heart Rate; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D010808:Physical Examination / Q000706:statistics & numerical data; D012372:ROC Curve; D012044:Regression Analysis; D012737:Sex Factors; D055105:Waist Circumference
D008055:Lipids; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain