Effects of (60)co whole-body gamma-irradiation in different doses on the distribution of (188)Re-labeled autologous mesenchymal stem cells in wistar rats after intravenous (systemic) transplantation during different periods after exposure.
The effects of whole-body gamma-irradiation in different doses on the distribution of (188)Re-labeled mesenchymal stem cells obtained by culturing of the rat bone marrow cells were studied in different organs and tissues of animals after intravenous (systemic) injection. Irradiation stimulated homing of (188)Re-labeled mesenchymal stem cells in organs and tissues of animals in comparison with this process in intact non-irradiated rats. The intensity of homing increased with increasing the irradiation dose and decreased with prolongation of the period between irradiation and systemic transplantation. It was hypothesized that increased migration of transplanted mesenchymal stem cells into irradiated organs and tissues can be caused by developing cell death processes. It seems that systemic transplantation of mesenchymal stem cells shortly after irradiation can be used for stimulation of reparative processes in damaged tissues.
Konoplyannikov
A G
AG
Medical of Radiologic Research Center, Obninsk, Russia. konopl@mrrc.obninsk.ru
Petriev
V M
VM
Konoplyannikova
O A
OA
Kal'sina
S Sh
SSh
Lepechina
L A
LA
Smorizanova
O A
OA
Semenkova
I V
IV
Agaeva
E V
EV
D000818:Animals; D002478:Cells, Cultured; D003037:Cobalt Radioisotopes / Q000008:administration & dosage* / Q000494:pharmacology; D005720:Gamma Rays; D007275:Injections, Intravenous; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism; D011829:Radiation Dosage; D011868:Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013997:Time Factors; D014018:Tissue Distribution / Q000528:radiation effects; D014182:Transplantation, Autologous; D014916:Whole-Body Irradiation / Q000379:methods*
D003037:Cobalt Radioisotopes; D011868:Radioisotopes; D012211:Rhenium