Gene expression: dialing up the frequency.
Cells often respond to external signals by altering their gene expression. The external signaling information is transduced and typically encoded in concentrations of relevant transcription factors. A recent study demonstrates that, by encoding this information in the frequency with which genes 'see' a transcription factor, the expression of hundreds of genes can be modulated in a linearly proportional manner.
Maheshri
Narendra
N
Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. narendra@mit.edu
D020013:Calcium Signaling; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D053263:Gene Regulatory Networks; D005800:Genes, Fungal; D008957:Models, Genetic; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
C109868:CRZ1 protein, S cerevisiae; D004268:DNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors