Necroptosis: a specialized pathway of programmed necrosis.
Necrosis is often viewed as an accidental and unregulated cellular event. However, accumulating evidence suggests that necrosis, like apoptosis, can be executed by regulated mechanisms. Hitomi et al. (2008) now describe an extensive network of genes that mediate a form of programmed necrosis called necroptosis.
Galluzzi
Lorenzo
L
INSERM, U848, F-94805 Villejuif, France.
Kroemer
Guido
G
D000818:Animals; D017209:Apoptosis; D006801:Humans; D009336:Necrosis; D015398:Signal Transduction