title: Successful management of a cervical twin pregnancy: neoadjuvant systemic methotrexate and prophylactic high cervical cerclage before curettage.
abstract: OBJECTIVE
  To report our experience in managing a case of viable cervical twin pregnancy with systemic methotrexate and 2 weeks later with endocervical curettage after placing prophylactic high cervical cerclage.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University medical center.
  
  
  METHODS
  A 36-year-old woman, gravida 2, para 0, complaining of vaginal bleeding and pelvic pain, in whom cervical twin pregnancy was diagnosed at the sixth week of gestation.
  
  
  METHODS
  Systemic methotrexate was given as first-line treatment. Two weeks later because of persisting bleeding, endocervical curettage was performed after closing cervical arteries and placing but not tightening high cervical cerclage.
  
  
  METHODS
  Pregnancy termination, bleeding control, and preservation of fertility.
  
  
  RESULTS
  Notwithstanding the ligature of cervical arteries at curettage, heavy bleeding occurred, which was controlled rapidly by tightening the cerclage. Curettage then was completed successfully. Postoperative period was uneventful. Two years later the woman delivered vaginally.
  
  
  CONCLUSIONS
  In case of cervical twin pregnancy methotrexate pretreatment and prophylactic placement of high cervical cerclage, but not ligature of cervical arteries, before curettage showed to be effective in terminating pregnancy ensuring effective bleeding control and preservation of fertility.
authors.affiliation: Department of Gynaecology, Obstetrics and Neonatology, University Hospital, Bari, Italy. giutrojano@gmail.com
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Trojano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Colafiglio
authors.forename: Nicola
authors.initials: N
authors.lastname: Saliani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lanzillotti
authors.forename: Ettore
authors.initials: E
authors.lastname: Cicinelli
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal; D000032:Abortion, Therapeutic / Q000379:methods*; D000328:Adult; D023802:Cerclage, Cervical; D004107:Dilatation and Curettage; D005260:Female; D005298:Fertility; D006801:Humans; D050498:Live Birth; D008727:Methotrexate; D017699:Pelvic Pain / Q000209:etiology / Q000601:surgery; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome; D014427:Twins; D016216:Ultrasonography, Prenatal; D014592:Uterine Hemorrhage / Q000209:etiology / Q000601:surgery
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate