Relative efficiency of the EQ-5D, HUI2, and HUI3 index scores in measuring health burden of chronic medical conditions in a population health survey in the United States.
OBJECTIVE
We sought to compare the ability of the EQ-5D, Health Utilities Index Mark 2 (HUI2), and HUI Mark 3 (HUI3) index scores to discriminate between respondents based on the presence or absence of chronic medical conditions in a population health survey.


METHODS
Secondary analyses were conducted with data from a probability sample (n = 3480, mean age: 42.5 years, male: 42.4%, Hispanic: 28.6%) of the 2001 noninstitutionalized US general adult population. F-statistic ratios were used to evaluate the relative efficiency of the EQ-5D, HUI2, and HUI3 in differentiating respondents with or without each of 18 chronic medical conditions, and differentiating respondents with low- or high-burden conditions.


RESULTS
In comparing respondents with and without chronic medical conditions, the F-statistic values of these 3 indices were not significantly different, except for EQ-5D versus HUI2 [mean F-statistic ratio: 0.79, 95% confidence interval (CI): 0.59-0.98]. In comparing respondents with a low-burden condition with those with a high-burden condition, the F-statistic values of EQ-5D and HUI2 index scores were similar, while those for EQ-5D versus HUI3 (mean: 0.79; 95% CI: 0.66-0.92) and for HUI2 versus HUI3 (mean: 0.83; 95% CI: 0.71-0.95) were significantly less than 1.0. The overall ceiling effects of the EQ-5D, HUI2, and HUI3 index scores were 48.9%, 15.4%, and 15.3%, respectively.


CONCLUSIONS
Although the EQ-5D seems to be marginally less informative, the EQ-5D, HUI2, and HUI3 index scores were generally comparable in determining health burden of chronic medical conditions in this population health survey data.
Luo
Nan
N
Department of Community, Occupational and Family Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. medln@nus.edu.sg
Johnson
Jeffrey A
JA
Shaw
James W
JW
Coons
Stephen Joel
SJ
D000203:Activities of Daily Living; D000328:Adult; D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease / Q000145:classification* / Q000208:ethnology / Q000523:psychology*; D017281:Cost of Illness; D003863:Depression; D004526:Efficiency; D005260:Female; D006304:Health Status; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008875:Middle Aged; D051346:Mobility Limitation; D010146:Pain; D011594:Psychometrics / Q000295:instrumentation*; D012648:Self Care; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires; D014481:United States; D055815:Young Adult