Melanin synthesis inhibitors from Lespedeza cyrtobotrya.
From the roots of Lespedeza cyrtobotrya, 45 flavonoids were isolated along with 20 new and 25 known compounds. Lipophilic flavonoids 2, 3, 7, 9, 11, 28, 30, and 39 exhibited strong inhibitory activities on melanin synthesis in normal human epidermal melanocytes.
Mori-Hongo
Maya
M
School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka 422-8526, Japan.
Yamaguchi
Hiromi
H
Warashina
Tsutomu
T
Miyase
Toshio
T
D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007564:Japan; D029884:Lespedeza / Q000737:chemistry*; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008544:Melanocytes / Q000187:drug effects*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry
D005419:Flavonoids; D008543:Melanins