Predictive factors for the regression of canine transmissible venereal tumor during vincristine therapy.
Canine transmissible venereal tumor (CTVT) is a neoplasm transmitted by transplantation. Monochemotherapy with vincristine is considered to be effective, but treatment time until complete clinical remission may vary. The aim of this study was to determine which clinical data at diagnosis could predict the responsiveness of CTVT to vincristine chemotherapy. One hundred dogs with CTVT entered this prospective study. The animals were treated with vincristine sulfate (0.025 mg/kg) at weekly intervals until the tumor had macroscopically disappeared. The time to complete remission was recorded. A multivariate Cox regression model indicated that larger tumor mass, increased age and therapy during hot and rainy months were independent significant unfavorable predictive factors retarding remission, whereas sex, weight, status as owned dog or breed were of no predictive relevance. Further studies are necessary to investigate whether these results are due to changes in immunological response mechanisms in animals with a diminished immune surveillance, resulting in delays in tumor regression.
Scarpelli
Karime C
KC
Faculty of Medical Sciences, University of Campinas, 13083-887, Campinas, SP, Brazil.
Valladão
Maria L
ML
Metze
Konradin
K
D000367:Age Factors; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female; D008297:Male; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012074:Remission Induction / Q000379:methods; D012621:Seasons; D016896:Treatment Outcome; D014685:Venereal Tumors, Veterinary / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use*
D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine