Microencapsulation of tamoxifen: application to cotton fabric.
Tamoxifen microcapsules and drug loaded medicated fabrics were investigated. The microcapsules were prepared using a complex coacervation procedure involving gelatin B and acacia gum. The morphology, particle size, drug loading capacity and in vitro release characteristics of the drug microcapsules were optimized for coating tamoxifen microcapsules onto the cotton fabrics. Infrared (IR) spectra and SEM were used to characterize the medicated fabrics and air permeability and laundering testing were undertaken to determine the efficiency and effectiveness of the system. Results showed that optimum condition for the microcapsules was at drug/polymer ratio 1:4, polymer concentration 3%, and rate of stirring 1000 rpm. In vitro release assays demonstrated that the tamoxifen was liberated over 10h after an initial bust rate period. SEM images illustrated that the tamoxifen microcapsules were spherical in shape and were also tightly fixed on to the cotton fabrics fast. These observations demonstrate that we have designed and fabricated a medicated system that potentially could be applied within a transdermal drug delivery system and so act in a system for the treatment of breast cancer.
Ma
Zong-Hui
ZH
College of Chemistry, Chemical Engineering and Biotechnology, Donghua, University, Shanghai 201620, China.
Yu
Deng-Guang
DG
Branford-White
Christopher J
CJ
Nie
Hua-Li
HL
Fan
Zai-Xia
ZX
Zhu
Li-Min
LM
D000388:Air; D002214:Capsules / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods*; D003368:Gossypium / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D010539:Permeability; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013629:Tamoxifen / Q000737:chemistry*
D002214:Capsules; D013629:Tamoxifen