title: Imaging E-selectin expression following traumatic brain injury in the rat using a targeted USPIO contrast agent.
abstract: BACKGROUND
  The aim of this work was to map E-selectin expression in a traumatic brain injury model using a newly-designed MR contrast agent. Iron cores, responsible for susceptibility effects and therefore used as T2* contrast agents, need to be coated in order to be stabilized and need to be targeted to be useful.
  
  
  METHODS
  We have designed a molecule coating composed, at one end, of bisphosphonate to ensure anchorage of the coating on the iron core and, at the other end, of Fukuda's defined heptapeptide known to target selectin binding sites.
  
  
  CONCLUSIONS
  The synthesized nanoparticles were able to non-invasively target the traumatic brain lesion, inducing a specific T2* decrease of about 25% up to at least 70 min post-injection of the targeted contrast agent.
authors.affiliation: INSERM U 646, Ingénierie de la Vectorisation Particulaire, 10 rue André Boquel, Angers, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Chapon
authors.forename: Florence
authors.initials: F
authors.lastname: Franconi
authors.forename: Franck
authors.initials: F
authors.lastname: Lacoeuille
authors.forename: François
authors.initials: F
authors.lastname: Hindré
authors.forename: Patrick
authors.initials: P
authors.lastname: Saulnier
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Benoit
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Le Jeune
authors.forename: Laurent
authors.initials: L
authors.lastname: Lemaire
mesh_terms: D000818:Animals; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D003287:Contrast Media / Q000737:chemistry; D003911:Dextrans; D004164:Diphosphonates / Q000737:chemistry; D019040:E-Selectin / Q000378:metabolism*; D005260:Female; D052203:Ferrosoferric Oxide; D007501:Iron; D058185:Magnetite Nanoparticles; D053758:Nanoparticles; D009842:Oligopeptides / Q000737:chemistry; D010087:Oxides; D011092:Polyethylene Glycols / Q000737:chemistry; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D013667:Technetium
chemical_list: D003287:Contrast Media; D003911:Dextrans; D004164:Diphosphonates; D019040:E-Selectin; D058185:Magnetite Nanoparticles; D009842:Oligopeptides; D010087:Oxides; C097921:ferumoxtran-10; D011092:Polyethylene Glycols; D013667:Technetium; D007501:Iron; D052203:Ferrosoferric Oxide