title: Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with metal ions, and DNA binding studies.
abstract: Liriodenine (), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (), cis-[PtCl2(L)(DMSO)] (), and cis-[RuCl2(L)(DMSO)2].1.5H2O (), the crystal structures of , and were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, 1H and 13C NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of and complexes against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free , suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of and its complexes to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.
authors.affiliation: The Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education), School of Chemistry & Chemical Engineering of Guangxi Normal University, Guilin 541004, P. R. China. chenzfubc@yahoo.com
authors.forename: Zhen-Feng
authors.initials: ZF
authors.lastname: Chen
authors.forename: Yan-Cheng
authors.initials: YC
authors.lastname: Liu
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Liu
authors.forename: Heng-Shan
authors.initials: HS
authors.lastname: Wang
authors.forename: San-Hai
authors.initials: SH
authors.lastname: Qin
authors.forename: Bo-Long
authors.initials: BL
authors.lastname: Wang
authors.forename: He-Dong
authors.initials: HD
authors.lastname: Bian
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Hoong-Kun
authors.initials: HK
authors.lastname: Fun
authors.forename: Hua-Gang
authors.initials: HG
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Liang
authors.forename: Chris
authors.initials: C
authors.lastname: Orvig
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002942:Circular Dichroism; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D017671:Platinum Compounds / Q000737:chemistry* / Q000494:pharmacology; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology; D032106:Zanthoxylum / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001060:Aporphines; D017671:Platinum Compounds; D017975:Ruthenium Compounds; D004247:DNA; C026980:liriodenine