title: Association between symptom duration and cerebrospinal fluid pressure, protein concentration, and number of cells in patients with intracranial hypotension.
abstract: We sought to investigate the association between symptom duration and cerebrospinal fluid (CSF) pressure, protein concentration, and cell counts in patients with intracranial hypotension, in addition to examining differences between spontaneous and post-traumatic types. We investigated 115 consecutive patients with CSF leaks, demonstrated by radionuclide cisternography. In patients with spontaneous CSF leaks, a significant decrease in pressure and increase in protein concentration and number of cells were observed in patients with a symptom duration of <or=3 months compared to those with >3 months. Symptom duration was not associated with those CSF parameters in patients with post-traumatic CSF leaks.
authors.affiliation: Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi, Tokyo, Japan. ns-waki@med.teikyo-u.ac.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Ohwaki
authors.forename: Eiji
authors.initials: E
authors.lastname: Yano
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Ishii
authors.forename: Shigehiko
authors.initials: S
authors.lastname: Takanashi
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Nakagomi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D002452:Cell Count; D002555:Cerebrospinal Fluid / Q000166:cytology*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis / Q000378:metabolism*; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D019585:Intracranial Hypotension / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000000981:diagnostic imaging; D007964:Leukocytosis / Q000175:diagnosis / Q000209:etiology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009192:Myelography; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D011868:Radioisotopes