[Relationship between Ghrelin polymorphism and serum lipoprotein levels in Han Chinese with or without coronary heart disease risk factors].
OBJECTIVE
To investigate the relationship between polymorphism of Ghrelin gene and serum levels of lipoprotein in Han Chinese with or without coronary heart disease (CHD) risk factors.


METHODS
PCR restriction fragment length polymorphism assay was used to detect the distribution of genotypes of Ghrelin gene in 225 Han Chinese (40 to 69 years-old) with CHD risk factors, 78 subjects without CHD risk factors served as normal controls. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein (VLDL) were measured to analyze the relationship with the polymorphism of Ghrelin gene.


RESULTS
Ghrelin genotype frequencies of AA, AG, GG (0.975, 0.025, 0.00 in control group and 0.956, 0.040, 0.004 in the high-risk group, all P > 0.05) as well as the allele frequencies of A, G (0.987, 0.013 in control group and 0.976, 0.024 in the high-risk group, all P > 0.05) were similar between the groups. HDL-C levels of the Arg/Gln carriers were significantly lower than those of Arg/Arg carriers in control group and in the high-risk group (all P < 0.05).


CONCLUSIONS
Arg/Gln carriers were associated lower HDL-C levels in Han Chinese.
Xie
Xuan
X
Department of Endocrinology, Second Affiliated Hospital of Medical School, Xi'an Jiao Tong University, Xi'an 710004, China. xx662006@126.com
Zhang
Jing
J
Wang
Yu-huan
YH
Wang
Jun-hong
JH
Zhang
Chun-hong
CH
Ni
Hong-yan
HY
Yuan
Xiao-hong
XH
D000328:Adult; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D054439:Ghrelin / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
D008076:Cholesterol, HDL; D054439:Ghrelin