Cytochrome bd confers nitric oxide resistance to Escherichia coli.
The aerobic respiratory chain of Escherichia coli has two terminal quinol oxidases: cytochrome bo and cytochrome bd. Cytochrome bd was thought to function solely to facilitate micro-aerobic respiration. However, it has recently been shown to be overexpressed under conditions of nitric oxide (NO) stress; we show here that cytochrome bd is crucial for protecting E. coli cells from NO-induced growth inhibition by virtue of its fast NO dissociation rate.
Mason
Maria G
MG
Department of Biological Sciences, University of Essex, Wivenhoe Park, Colchester CO4 3SQ, UK.
Shepherd
Mark
M
Nicholls
Peter
P
Dobbin
Paul S
PS
Dodsworth
Kathryn S
KS
Poole
Robert K
RK
Cooper
Chris E
CE
D003573:Cytochrome b Group; D003580:Cytochromes / Q000378:metabolism*; D045222:Electron Transport Chain Complex Proteins / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*
D003573:Cytochrome b Group; D003580:Cytochromes; D045222:Electron Transport Chain Complex Proteins; D029968:Escherichia coli Proteins; D009569:Nitric Oxide; D010088:Oxidoreductases; C040077:cytochrome bd terminal oxidase complex, E coli