title: Pruritic urticarial papules and plaques of pregnancy wholly abated with one week twice daily application of fluticasone propionate lotion: a case report and review of the literature.
abstract: Pruritic urticarial papules and plaques of pregnancy (PUPPP) is among the most common dermatoses of pregnancy. Most reports of the effective treatment of PUPPP involve high potency topical corticosteroids or oral steroids. Many authorities have noted cases of PUPPP whose resolution followed parturition. A few have noted that PUPPP can arise and resolve the third trimester. A 36-year-old prima gravida at 38 weeks of gestation presented with a 2-week history of a pruritic papular abdominal eruption. She used fluticasone propionate 0.05 percent lotion twice a day. One week after starting this medication, the pruritus had resolved and the erythema/urticaria had abated; the pigmentary alteration had improved, but still remained. The PUPPP did not return after parturition. PUPPP can abate entirely during pregnancy. Fluticasone propionate 0.05 percent lotion, a class 5 (low-medium potency) corticosteroid, has a benign side effect profile and should be considered for the treatment of PUPPP during pregnancy.
authors.affiliation: Department of Dermatology, Columbia University, New York, NY, USA. NSS32@columbia.edu
authors.forename: Noah
authors.initials: N
authors.lastname: Scheinfeld
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage / Q000627:therapeutic use*; D004890:Erythema / Q000188:drug therapy / Q000209:etiology; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008548:Melanosis / Q000188:drug therapy / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011537:Pruritus / Q000188:drug therapy* / Q000209:etiology; D017444:Skin Diseases, Papulosquamous / Q000188:drug therapy* / Q000209:etiology; D014581:Urticaria / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000730:Androstadienes; D000068298:Fluticasone