One-pot preparation of substituted pyrroles from alpha-diazocarbonyl compounds.
In this work an efficient one-pot synthesis of substituted pyrroles 7a-n is described, which involves the in situ formation of dihydrofurans ethyl 5-butoxy-2-methyl-4,5-dihydrofuran-3-carboxylate (4), 1-(5-butoxy-2-methyl-4,5-dihydrofuran-3-yl)ethanone (5) and 5-butoxy-4,5-dihydrofuran-3-carbaldehyde (6) followed by reaction with primary amines.
da Silva
Fernando de C
Fde C
Universidade Federal Fluminense, Departamento de Química Orgânica, Instituto de Química, Outeiro de São João Baptista, CEP 24020-141, Niterói, RJ, Brazil.
Fonseca
Mauricio G
MG
Rianelli
Renata de S
Rde S
Cunha
Anna C
AC
de Souza
Maria C B V
MC
Ferreira
Vitor F
VF