title: [Multimodal therapy for juvenile advanced rectal carcinoma].
abstract: A 37-year-old male with locally advanced rectal carcinoma and liver metastasis was treated by multimodal therapy. Since he had severe anemia and perineal abscess, sigmoid colostomy was constructed. After his general condition was recovered, the patient received systemic chemotherapy with mFOLFOX6 (6 courses) and whole pelvic irradiation (40 Gy). The rectal tumor showed a reduction in size, total pelvic evisceration combined with reconstruction of ileal conduit and rectus abdominus myocutaneous (RAM) flap were performed. He was followed by 7 courses of systemic chemotherapy with mFOLFOX6 and bevacizumab. After partial hepatic resection, he was followed by systemic chemotherapy with FOLFIRI and bevacizumab as an outpatient. Recent studies for outcomes in young colorectal carcinoma patients showed that the poor prognosis was not caused by its proper aggressiveness in biologic behavior but just the late diagnosis.
authors.affiliation: Dept. of Surgery, Veritas Hospital.
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Katsumoto
authors.forename: Noriko
authors.initials: N
authors.lastname: Aritake
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000556:secondary / Q000601:surgery; D008297:Male; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D011795:Surveys and Questionnaires; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents