title: Synthesis of 1,4-dihydro-benzo[d][1,3]oxazin-2-ones from phthalides via an aminolysis-Hofmann rearrangement protocol.
abstract: A simple two-step procedure for the conversion of readily available phthalides to the corresponding benzoxazinones was developed. Initial ring-opening aminolysis to form a primary 2-hydroxymethylbenzamide, followed by reaction with bis(trifluoroacetoxy)iodobenzene (BTI) conveniently provided a variety of 4-substituted benzoxazinones.
authors.affiliation: Department of Pharmaceutical Sciences, School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, San Juan PR 00936.
authors.forename: Eliud
authors.initials: E
authors.lastname: Hernández
authors.forename: Jessica M
authors.initials: JM
authors.lastname: Vélez
authors.forename: Cornelis P
authors.initials: CP
authors.lastname: Vlaar