Transition-metal-catalyzed enantioselective [2+2+2] cycloadditions for the synthesis of axially chiral biaryls.
Recent advances towards a development of novel transition-metal-catalyzed enantioselective [2+2+2] cycloadditions for the synthesis of axially chiral biaryls are reviewed. A number of efficient enantioselective biaryl syntheses were accomplished by chiral cobalt(I), iridium(I), and rhodium(I) complex catalyzed [2+2+2] cycloadditions. Furthermore, the enantioselective synthesis of axially chiral biaryls possessing non-biaryl axial chirality was also developed by using chiral rhodium(I) complexes as catalysts.
Tanaka
Ken
K
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan. tanaka-k@cc.tuat.ac.jp