title: Relation of serum fetuin-A levels to coronary artery calcium in African-American patients on chronic hemodialysis.
abstract: Vascular calcium deposition in end-stage renal disease occurs commonly, but its relation to cardiovascular risk factors and fetuin-A levels in African Americans is not known. Compliant African American patients who were undergoing hemodialysis (HD; n = 17) agreed to undergo 64-slice multidetector computed tomography for the assessment of coronary artery calcium score (CACS). The relation between traditional cardiovascular risk factors (i.e., age; gender; dialysis vintage; history of diabetes; means of the previous 3 years of weekly predialysis blood pressure values and hemoglobin levels; means of monthly values of calcium, phosphorus, alkaline phosphatase, uric acid; and albumin; and means of quarterly measurements of parathyroid hormone and lipids) and fetuin-A levels and CACS was explored using univariate analyses. Serum phosphorus levels over the previous 3 years were well controlled. The CACS range was 0 to 3,877 Agatston units (mean 996, median 196). Among the tested variables, only fetuin-A was significantly and inversely associated with CACS (standardized beta = -0.64, 95% confidence interval -18.09 to -3.62, p = 0.006). There was no association between age and fetuin-A level (standardized beta = -0.02, 95% confidence interval -0.10 to 0.23). In conclusion, African-American patients who were undergoing long-term hemodialysis and with good phosphorus control exhibited a strong inverse correlation between fetuin-A level and CACS that was independent of age.
authors.affiliation: Division of Nephrology, Washington University School of Medicine, Saint Louis, Missouri, USA.
authors.forename: Sijie
authors.initials: S
authors.lastname: Zheng
authors.forename: Lisa
authors.initials: L
authors.lastname: de las Fuentes
authors.forename: Andrew
authors.initials: A
authors.lastname: Bierhals
authors.forename: Rachel
authors.initials: R
authors.lastname: Ash-Bernal
authors.forename: Karen
authors.initials: K
authors.lastname: Spence
authors.forename: Eduardo
authors.initials: E
authors.lastname: Slatopolsky
authors.forename: Victor G
authors.initials: VG
authors.lastname: Davila-Roman
authors.forename: James
authors.initials: J
authors.lastname: Delmez
mesh_terms: D000328:Adult; D001741:Black or African American; D000368:Aged; D001798:Blood Proteins / Q000378:metabolism*; D002114:Calcinosis / Q000097:blood / Q000208:ethnology* / Q000209:etiology; D002118:Calcium / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood / Q000208:ethnology* / Q000209:etiology; D003331:Coronary Vessels / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008923:Missouri / Q000453:epidemiology; D011379:Prognosis; D006435:Renal Dialysis / Q000379:methods*; D012307:Risk Factors; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D060749:alpha-2-HS-Glycoprotein
chemical_list: C556354:AHSG protein, human; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein; D002118:Calcium