Effects of gram-positive microorganisms and their products on in vivo survival of hemopoietic clonogenic cells.
The effects of gram-positive bacterial strains (Lactobacillus acidophilus and Lactobacillus rhamnosus) and their subcellular components on the survival of hemopoietic clonogenic cells were evaluated by the formation of endogenous splenic colonies. The effects of these preparations on NO production were studied by the spin-trap paramagnetic resonance spectroscopy. Bacterial preparations from gram-positive bacteria stimulated survival of hemopoietic clonogenic cells, but did not induce NO production in contrast to E. coli LPS.
Proskuryakov
S Ya
SY
Medical Radiology Research Center, Russian Academy of Medical Sciences, Obninsk, Russia. pros@mrrc.obninsk.ru
Konoplyannikov
A G
AG
Konoplyannikova
O A
OA
Tsyb
A F
AF
Logunov
D Yu
DY
Naroditsky
B S
BS
Gintsburg
A L
AL
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006094:Gram-Positive Bacteria / Q000737:chemistry / Q000166:cytology / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000382:microbiology / Q000502:physiology*; D007779:Lactobacillus acidophilus / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D052201:Lacticaseibacillus rhamnosus / Q000737:chemistry / Q000166:cytology / Q000502:physiology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013347:Subcellular Fractions / Q000502:physiology
D008070:Lipopolysaccharides