title: Thrombophilia testing in patients with venous thromboembolism. Findings from the RIETE registry.
abstract: BACKGROUND
  There is scarce information on the management habits with regard to thrombophilia testing in patients with venous thromboembolism (VTE).
  
  
  METHODS
  RIETE is an ongoing registry of consecutive patients with symptomatic VTE. Aimed to estimate the extent to which thrombophilia test ordering patterns are consistent with the recommendations by a 2005 international consensus statement, we retrospectively compared the clinical characteristics of all patients tested for thrombophilia and those who were not tested.
  
  
  RESULTS
  Of 21367 patients enrolled, 4494 (21%) were tested for thrombophilia: 1456 (32%) tested positive, 3038 (68%) negative. The most common abnormalities were: Factor V Leiden (N=376), antiphospholipid syndrome (N=289), and prothrombin G20210A (N=263). Overall, 12740 (60%) patients met one or more criteria of the consensus statement: 7894 (37%) had a first episode of idiopathic VTE; 4013 (19%) were aged <50 years; 133 (0.6%) were pregnant women; 758 (3.5%) were using estrogens; 3375 (16%) had recurrent VTE. Of them, 3618 (28%) underwent thrombophilia tests, 34% of whom tested positive. The percentage of patients testing positive was significantly higher in those aged <50 years, with no differences between idiopathic or secondary, first episode or recurrent VTE. Finally, 876 (10%) of the 8627 (40%) patients meeting no criteria were tested. Of these, 208 (24%) tested positive.
  
  
  CONCLUSIONS
  Twenty-eight percent of patients meeting one or more criteria for thrombophilia testing, and 10% of those with no criteria were actually tested. Thus, a substantial proportion of thrombophilia ordering is not consistent with the recommendations made by the consensus statement.
authors.affiliation: Department of Haematology and Clinical Oncology, Universidad de Murcia, Spain.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Roldan
authors.forename: Ramón
authors.initials: R
authors.lastname: Lecumberri
authors.forename: Juan Francisco Sánchez
authors.initials: JF
authors.lastname: Muñoz-Torrero
authors.forename: Vicente
authors.initials: V
authors.lastname: Vicente
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rocha
authors.forename: Benjamin
authors.initials: B
authors.lastname: Brenner
authors.forename: Manuel
authors.initials: M
authors.lastname: Monreal
mesh_terms: D000328:Adult; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis; D012042:Registries; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D019851:Thrombophilia / Q000175:diagnosis* / Q000235:genetics; D054556:Venous Thromboembolism / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult