title: [Biological profile of type I allergies at Mohamed V Hospital (Rabat- Morocco)].
abstract: Allergic diseases are ranked fourth considering the world health organization classification of diseases. The consequences linked to these ailments are huge for public health economics and the diagnosis is awkward due to clinical polymorphism and multifactorial aetiologies. The allergologic diagnosis is the result of weighing in clinical and biological findings. The biological assessment is made of qualitative specific and multiple-allergen serum IgE test, which once positive drives to skin test and each allergen-specific IgE level determination to conclude. Our study aims at displaying biological analysis results of incoming patients with clinical allergy conditions. We carried out a nine months retrospective study, from June 2007 to March 2008, with 200 outwards patients involved. Blood samples were collected using dry tubes and as recommended we first did screening tests for respiratory (Pharmacia Phadiatop) and food (fx 5) allergens, then for positive samples we proceeded to serum specific IgE assay (UniCap, Phadia). We also realized the total IgE assay on 46 patients using Roche Elecsys 2010 technology. 49% of patients enrolled in the study were positive to aerollergens, d1 Dermatophagoides pteronyssinus being the most incriminated (96.4%), and 2.5% to food allergens. On 13% of patients, we noticed a double sensitization to d1 and g6 (pollen of grasses). Concerning the total IgE dosage, we found 50% of patients tested with normal values, 28% of whom having a positive allergologic screening test. Further studies matching clinical data, skin tests to serum IgE assay are necessary to draw the profile of respiratory and dermatological allergies for our patients.
authors.affiliation: Service de biochimie, Hôpital militaire d'instruction Mohamed V, Rabat, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Bouhsain
authors.forename: Y
authors.initials: Y
authors.lastname: Kamouni
authors.forename: A
authors.initials: A
authors.lastname: Dami
authors.forename: A
authors.initials: A
authors.lastname: Zrara
authors.forename: S
authors.initials: S
authors.lastname: Mechtani
authors.forename: Z
authors.initials: Z
authors.lastname: Ouzzif
authors.forename: A
authors.initials: A
authors.lastname: Biaz
authors.forename: S
authors.initials: S
authors.lastname: Tellal
authors.forename: M
authors.initials: M
authors.lastname: Derouiche
mesh_terms: D000328:Adult; D000485:Allergens; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D005470:Fluorometry; D005512:Food Hypersensitivity / Q000175:diagnosis; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000276:immunology; D007124:Immunoenzyme Techniques; D007073:Immunoglobulin E / Q000032:analysis*; D009018:Morocco; D012130:Respiratory Hypersensitivity / Q000175:diagnosis; D012189:Retrospective Studies; D012882:Skin Tests
chemical_list: D000485:Allergens; D015415:Biomarkers; D007073:Immunoglobulin E