title: Advanced gastric cancer showing long-term complete remission in response to S-1 monotherapy: two case reports.
abstract: We herein report two cases showing long-term complete remission (CR) in response to S-1 monotherapy. Case 1 was a 65-year-old male diagnosed with an advanced poorly differentiated adenocarcinoma of the stomach with paraaortic lymph node metastases, which disappeared after S-1 monotherapy. Subsequently a total gastrectomy was performed, and histological CR was evident. His progress is presently uneventful without recurrence 50 months after surgery. Case 2 was a 59-year-old female who underwent a total gastrectomy with a jejunal pouch. The resected tumor was a medullary type poorly differentiated adenocarcinoma infiltrating the serosa and involving the regional lymph nodes. One year after surgery, endoscopy revealed a recurrent tumor in the jejunal pouch. After the administration of S-1, this recurrent tumor completely disappeared, and she has since maintained CR for 39 months. These cases suggest that a subgroup of patients with advanced gastric cancer may attain CR with S-1 monotherapy.
authors.affiliation: Department of Clinical Research Laboratory (Pathology Division), Kanagawa 228-8522, Japan. h-mitomi@sagamihara-hosp.gr.jp.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Mitomi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kishimoto
authors.forename: Akifumi
authors.initials: A
authors.lastname: Amemiya
authors.forename: Goro
authors.initials: G
authors.lastname: Kaneda
authors.forename: Ken
authors.initials: K
authors.lastname: Adachi
authors.forename: Takuya
authors.initials: T
authors.lastname: Shimoda
authors.forename: Masakazu
authors.initials: M
authors.lastname: Takigawa
authors.forename: Naoshi
authors.initials: N
authors.lastname: Fukui
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohkura