Prolonged fecal shedding of CTX-M-15-producing Escherichia coli and recurrent sepsis in a patient after cord blood stem-cell transplantation.
An extended-spectrum beta-lactamase (CTX-M-15 type)-producing Escherichia coli persisted in the intestinal tract for >5 months in a pediatric patient after cord blood stem-cell transplantation and caused 2 episodes of sepsis. The bla(CTX-M-15) is carried by a large plasmid of approximately 130 kb in size. The prolonged shedding of the highly resistant E. coli posed a great challenge to infection control and public health.
Huang
Kuan-Ying
KY
Divisions of Pediatric Infectious Diseases, Department of Pediatrics, Chang GongChildren's Hospital, Taiwan.
Chia
Ju-Hsin
JH
Chiang
Chao-Ying
CY
Wu
Tsu-Lan
TL
Su
Lin-Hui
LH
Jaing
Tang-Her
TH
Lin
Tzou-Yien
TY
Chiu
Cheng-Hsun
CH
D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects*; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D004927:Escherichia coli Infections / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D005243:Feces / Q000382:microbiology*; D005260:Female; D006086:Graft vs Host Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D016133:Polymerase Chain Reaction; D012008:Recurrence; D018805:Sepsis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology*; D018440:beta-Lactam Resistance / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; C473109:beta-lactamase CTX-M-15; D001618:beta-Lactamases