Synthesis and immunosuppressive activity of lipophilic amino alcohols and diamines.
In this work, we report the preparation and evaluation of the in vitro and in vivo of the immunosuppressive activity of a series of lipophilic amino alcohols and diamines. All compounds were evaluated for inhibition of cell proliferation, cytotoxicity and NO production. Compounds 9, 12, 13, 17, and 18 did not display inhibition of cell proliferation while decreased NO production. The two most potent compounds, 13 and 17, submitted to delayed-type hypersensitivity assays showed immunosuppressive activity.
Reis
Elaine F C
EF
Departamento de Química, Universidade Federal de Juiz de Fora, Juiz de Fora-MG 36036-330, Brazil.
Celso
O R
OR
Alves
Lívia L
LL
Ferreira
Ana Paula
AP
de Almeida
Mauro V
MV
D000605:Amino Alcohols / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D002478:Cells, Cultured; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051379:Mice
D000605:Amino Alcohols; D003959:Diamines; D007166:Immunosuppressive Agents