Central neuropeptide Y in anxiety- and stress-related behavior and in ethanol intake.
One of the most profound properties of central neuropeptide Y (NPY) is its anxiolytic, or anti-anxiety, effect. This has been demonstrated repeatedly in a number of animal models. In addition, stressors affect NPY expression in the central nervous system, with acute and repeated (chronic) stress having differential effects. Here, a brief summary of some work performed in our laboratory is presented that supports a role for NPY in regulation of stress responses and behaviors.
Thorsell
Annika
A
Laboratory of Clinical and Translational Studies, National Institutes of Health/National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland 20892-1108, USA. annika.thorsell@mail.nih.gov
D000428:Alcohol Drinking; D000818:Animals; D001007:Anxiety / Q000378:metabolism* / Q000503:physiopathology; D001522:Behavior, Animal / Q000502:physiology*; D000431:Ethanol / Q000008:administration & dosage*; D009478:Neuropeptide Y / Q000378:metabolism*; D020033:Protein Isoforms / Q000378:metabolism; D017476:Receptors, Neuropeptide Y / Q000378:metabolism; D013315:Stress, Psychological
D009478:Neuropeptide Y; D020033:Protein Isoforms; D017476:Receptors, Neuropeptide Y; D000431:Ethanol