[Effects of mechanical ventilation on plasma IL-6, IL-10 and TNF-alpha in children after cardiopulmonary bypass].
OBJECTIVE
To study the effects of different models of mechanical ventilation on inflammatory cytokines, IL-6, IL-10 and TNF-alpha, in children after cardiopulmonary bypass (CPB).


METHODS
Sixty patients who underwent CPB were randomly divided into group A and group B. After CPB, group A was ventilated with high tidal volume (VT, 10-12 mL/kg) /low positive end-expiratory pressure (PEEP, 3-5 cm H2O), while group B was ventilated with low VT (6-8 mL/kg) /high PEEP (6-9 cm H2O). Plasma levels of IL-6, IL-10 and TNF-alpha were measured before operation, at the end of the operation, and 1 and 6 hrs after operation.


RESULTS
Serum levels of IL-6, IL-10 and TNF-alpha in both groups increased significantly at the end of the operation and reached a peak by 1 hr after operation. Group B showed lower serum levels of IL-6, IL-10 and TNF-alpha than group A 1 and 6 hrs after operation.


CONCLUSIONS
Mechanical ventilation with low VT /high PEEP may more effectively inhibit the release of inflammatory cytokines than that with high VT /low PEEP in children after CPB.
Huang
Peng
P
Department of Cardiothoracic Surgery, Hunan Children's Hospital, Changsha 410007, China. lilyhp_911@yahoo.com.cn
Zhou
Wen-Wu
WW
Liu
Ping-Bo
PB
D002315:Cardiopulmonary Bypass; D005260:Female; D006801:Humans; D007223:Infant; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D012121:Respiration, Artificial; D014409:Tumor Necrosis Factor-alpha
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10