title: Machilin A isolated from Myristica fragrans stimulates osteoblast differentiation.
abstract: This study evaluated the stimulatory effects of machilin A and structurally related lignans isolated from Myristica fragrans on osteoblast differentiation. In two IN VITRO osteoblast differentiation models, machilin A stimulated osteoblast differentiation via activation of p38 MAP kinase. Lignans isolated from Myristica fragrans also stimulated osteoblast differentiation in MC3T3-E1 cells; the lignans included macelignan, machilin F, nectandrin B, safrole, licarin A, licarin B, myristargenol, and meso-dihydroguaiaretic acid. These data suggest that lignans isolated from Myristica fragrans have anabolic activity in bone metabolism.
authors.forename: Su-Ui
authors.initials: SU
authors.lastname: Lee
authors.forename: Ki Shuk
authors.initials: KS
authors.lastname: Shim
authors.forename: Shi Yong
authors.initials: SY
authors.lastname: Ryu
authors.forename: Yong Ki
authors.initials: YK
authors.lastname: Min
authors.forename: Seong Hwan
authors.initials: SH
authors.lastname: Kim
mesh_terms: D016475:3T3 Cells; D000469:Alkaline Phosphatase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D052117:Benzodioxoles / Q000302:isolation & purification / Q000494:pharmacology*; D001842:Bone and Bones / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D024042:Collagen Type I / Q000235:genetics / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D007093:Imidazoles / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D026323:Myristica / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects*; D015675:Osteocalcin / Q000235:genetics / Q000378:metabolism; D053495:Osteopontin / Q000235:genetics / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology; D012639:Seeds; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000235:genetics*
chemical_list: D052117:Benzodioxoles; D024042:Collagen Type I; D004791:Enzyme Inhibitors; D007093:Imidazoles; D017705:Lignans; D010936:Plant Extracts; D011725:Pyridines; C506896:Spp1 protein, mouse; C539438:machilin A; D015675:Osteocalcin; D053495:Osteopontin; D048051:p38 Mitogen-Activated Protein Kinases; D000469:Alkaline Phosphatase; C093642:SB 203580