title: Artificial muscle to wash blood out of fibrillating atrium: an alternative to lifelong anticoagulation.
abstract: The Atripump is a motorless, volume displacement pump based on artificial muscle technology that could reproduce the pump function of normal atrium. It could help prevent blood clots due to blood stagnation and eventually avoid anticoagulation therapy in atrial fibrillation (AF). An animal study has been designed to assess mechanical effects of this pump on fibrillating atrium. The Atripump is a dome shaped silicone coated nitinol actuator. A pacemaker like control unit drives the actuator. In five adult sheep, the right atrium (RA) was exposed and dome sutured onto the epicardium. Atrial fibrillation was induced using rapid epicardial pacing (600 beats/min). Ejection fraction of the RA was obtained with intracardiac ultrasound in baseline, AF and Atripump assisted AF conditions. The dome's contraction rate was 60/min with power supply of 12V, 400 mA for 200 ms and ran for 2 hours in total. Mean temperature on the RA was 39+/-1.5 degrees C. Right atrium ejection fraction was 31% in baseline conditions, 5% and 20% in AF and assisted AF, respectively. In two animals a thrombus appeared in the right appendix and washed out once the pump was turned on. The Atripump washes blood out the RA acting as an anticoagulant device. Possible clinical implications in patients with chronic AF are prevention of embolism of cardiac origin and avoidance of hemorrhagic complication due to chronic anticoagulation.
authors.affiliation: Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. piergiorgio.tozzi@chuv.ch
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Tozzi
authors.forename: Daniel
authors.initials: D
authors.lastname: Hayoz
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Siniscalchi
authors.forename: Francois
authors.initials: F
authors.lastname: Salchli
authors.forename: Ludwig K
authors.initials: LK
authors.lastname: von Segesser
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001187:Artificial Organs; D001281:Atrial Fibrillation / Q000188:drug therapy / Q000601:surgery*; D006353:Heart-Assist Devices; D006439:Hemodynamics; D009206:Myocardium; D011474:Prosthesis Design; D012756:Sheep; D013927:Thrombosis / Q000517:prevention & control*
chemical_list: D000925:Anticoagulants