title: Secondary membranous glomerulonephritis associated with recipient residual lymphoma cells after allogeneic bone marrow transplantation.
abstract: A 29-year-old man with malignant lymphoma developed membranous nephropathy (MN) after allogeneic bone-marrow transplantation (BMT). There had been no obvious findings of graft versus host diseases (GVHD) after BMT, and the dosage of immunosuppressant drugs had not been reduced during this period. At the onset of MN, a few lymphoma cells still remained in the bone marrow; the patient achieved complete remission of MN after the disappearance of the lymphoma cells. In this case it is suggested that immune complexes including antigens expressed by lymphoma cells might induce MN. Therefore, this is a significant case that may reveal an alternative mechanism of the onset of MN related to BMT.
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Sakai
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Joichi
authors.initials: J
authors.lastname: Usui
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Hirayasu
authors.initials: H
authors.lastname: Kai
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hagiwara
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Morito
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Chie
authors.initials: C
authors.lastname: Saito
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Keigyou
authors.initials: K
authors.lastname: Yoh
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan.
authors.forename: Syuichi
authors.initials: S
authors.lastname: Tsuruoka
authors.affiliation: Department of Nephrology, Tokyo Medical University Kasumigaura Hospital, Ami, Ibaraki, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Hirayama
authors.affiliation: Department of Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Aita
authors.affiliation: Department of Pathology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
authors.forename: Michio
authors.initials: M
authors.lastname: Nagata
authors.affiliation: Pathophysiology of Renal Diseases, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, 305-8575, Japan. kidney@md.tsukuba.ac.jp.
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Yamagata
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D015433:Glomerulonephritis, Membranous / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008223:Lymphoma / Q000150:complications* / Q000276:immunology / Q000628:therapy*; D008297:Male; D018365:Neoplasm, Residual / Q000150:complications* / Q000276:immunology; D012074:Remission Induction; D014184:Transplantation, Homologous
chemical_list: D007074:Immunoglobulin G