Literature-curated protein interaction datasets.
High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.
Cusick
Michael E
ME
Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. michael_cusick@dfci.harvard.edu
Yu
Haiyuan
H
Smolyar
Alex
A
Venkatesan
Kavitha
K
Carvunis
Anne-Ruxandra
AR
Simonis
Nicolas
N
Rual
Jean-François
JF
Borick
Heather
H
Braun
Pascal
P
Dreze
Matija
M
Vandenhaute
Jean
J
Galli
Mary
M
Yazaki
Junshi
J
Hill
David E
DE
Ecker
Joseph R
JR
Roth
Frederick P
FP
Vidal
Marc
M
D000818:Animals; D016208:Databases, Factual; D030562:Databases, Protein; D006801:Humans; D011485:Protein Binding; D011506:Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D015203:Reproducibility of Results; D012107:Research Design
D011506:Proteins