title: Effects of pregnancy on the solubility of halogenated volatile anaesthetics in rat blood and tissues.
abstract: This study was designed to evaluate the effects of pregnancy on the solubility of halogenated volatile anaesthetics in rat blood and tissues. Tissue samples from 10 pregnant and 10 non-pregnant adult female Sprague Dawley rats, including the heart, liver, kidney and brain, were obtained and made into respective homogenates. Blood/gas and tissue/gas partition coefficients for halothane, sevoflurane and isoflurane were determined by the method of two-stage headspace equilibration by gas chromatography with each of the homogenates. Values were analysed by t-test or one-way analysis of variance. The solubility within blood and brain for halothane in the pregnant group (2.90 +/- 0.44, 5.55 +/- 0.73) was significantly lower than that of the non-pregnant group (3.42 +/- 023, 6.33 +/- 0.64; P < 0.05). However, there were no significant differences between the two groups for liver, kidney or heart solubility. For sevoflurane and isoflurane, there were no significant differences in solubility between the two groups. In conclusion, pregnancy decreased the solubility of halothane within the blood and brain, whereas the solubility of halothane in other tissues including the liver, kidney and heart showed no significant alteration. Pregnancy did not affect the solubility ofsevoflurane or isoflurane within blood or the other tissues studied.
authors.affiliation: Department ofAnesthesiology, Zhongnan Hospital, Wuhan University, Hubei, PR China.
authors.forename: Y
authors.initials: Y
authors.lastname: Rao
authors.forename: Y L
authors.initials: YL
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: J
authors.initials: J
authors.lastname: Liu
mesh_terms: D000704:Analysis of Variance; D018685:Anesthetics, Inhalation / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002849:Chromatography, Gas / Q000379:methods; D005260:Female; D006221:Halothane / Q000097:blood / Q000493:pharmacokinetics; D007530:Isoflurane / Q000097:blood / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008738:Methyl Ethers / Q000097:blood / Q000493:pharmacokinetics; D009206:Myocardium / Q000378:metabolism*; D011247:Pregnancy / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000077149:Sevoflurane; D012995:Solubility
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D006221:Halothane