title: The role of parity in medical abortion up to 49 days of amenorrhoea.
abstract: OBJECTIVE
  To identify possible risk factors for failure of medical abortion.
  
  
  METHODS
  Retrospective study of data collected between 1 January 2001 and 31 December 2005, concerning 1850 women who, for medical abortion up to 49 days of amenorrhoea, had received 600 mg oral mifepristone followed 48 h later by 400 microg oral misoprostol and, if necessary, a second oral dose of 400 microg.
  
  
  RESULTS
  The method was effective in 97.1% of cases. Fifty four failures (2.9%) were recorded, including seven continuing pregnancies (0.4%). The global efficacy rate of this mifepristone-misoprostol regimen is among the best using similar treatment protocols. The proportion of failures augmented with parity.
  
  
  CONCLUSIONS
  This study suggests that parity is a major factor influencing the success of medical abortion. A greater parity of the patients was associated with a lower efficacy of treatment.
authors.affiliation: Service d'Orthogenie, Centre Hospitalier de Roubaix, Roubaix, France. philippe.lefebvre@ch-roubaix.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Lefebvre
authors.forename: Martine
authors.initials: M
authors.lastname: Cotte
authors.forename: Nicole
authors.initials: N
authors.lastname: Monniez
authors.forename: Gerard
authors.initials: G
authors.lastname: Norel
mesh_terms: D000021:Abortifacient Agents, Steroidal / Q000008:administration & dosage / Q000009:adverse effects; D000028:Abortion, Induced / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D006063:Chorionic Gonadotropin / Q000097:blood; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008875:Middle Aged; D015735:Mifepristone / Q000008:administration & dosage / Q000009:adverse effects; D016595:Misoprostol / Q000008:administration & dosage / Q000009:adverse effects; D010298:Parity; D011247:Pregnancy; D012372:ROC Curve; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000021:Abortifacient Agents, Steroidal; D006063:Chorionic Gonadotropin; D016595:Misoprostol; D015735:Mifepristone