title: Alternative splicing of CD45: the tip of the iceberg.
abstract: Mechanisms underlying the regulated splicing of CD45 RNA have been long-standing puzzles. In this issue of Immunity, Wu et al. (2008) identify hnRNPLL as a critical regulator of both signal-induced exon skipping in CD45 and global alternative-transcript expression in memory T cells.
authors.affiliation: Division of Rheumatology, Rosalind Russell Medical Research Center for Arthritis, Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA 94143, USA.
authors.forename: Julie
authors.initials: J
authors.lastname: Zikherman
authors.forename: Arthur
authors.initials: A
authors.lastname: Weiss
mesh_terms: D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D005091:Exons / Q000235:genetics*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics*; D051379:Mice; D020033:Protein Isoforms / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D017493:Leukocyte Common Antigens