title: The fat controller: roles of palmitoylation in intracellular protein trafficking and targeting to membrane microdomains (Review).
abstract: The attachment of palmitic acid to the amino acid cysteine via thioester linkage (S-palmitoylation) is a common post-translational modification of eukaryotic proteins. In this review, we discuss the role of palmitoylation as a versatile protein sorting signal, regulating protein trafficking between distinct intracellular compartments and the micro-localization of proteins within membranes.
authors.affiliation: The Centre for Integrative Physiology, School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Greaves
authors.forename: Gerald R
authors.initials: GR
authors.lastname: Prescott
authors.forename: Oforiwa A
authors.initials: OA
authors.lastname: Gorleku
authors.forename: Luke H
authors.initials: LH
authors.lastname: Chamberlain
mesh_terms: D006801:Humans; D054878:Lipoylation; D021962:Membrane Microdomains / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*
chemical_list: D021382:Protein Sorting Signals; D011506:Proteins