Hybrid microgels with antibacterial properties.
In the present work, we have used aqueous microgels as containers for the deposition of silver nanoparticles (AgNPs). It has been shown that AgNPs can be effectively incorporated in the microgel interior during the in situ reduction of silver ions. Obtained hybrid microgels with variable AgNPs loading (from 1 to 12 wt.-%) have been used as antibacterial agents for two bacteria types. The experimental results indicate that porous microgel structure allows the release of the silver ions from the AgNPs surface into an aqueous phase. This ensures effective reduction in the number of bacterial colonies in test plates and complete bacteria killing. The antibacterial efficiency of the microgel particles increases with AgNPs loading.
Häntzschel
Nadine
N
Department of Macromolecular Chemistry and Textile Chemistry, Technische Universität Dresden, Dresden, Germany.
Hund
Rolf-Dieter
RD
Hund
Heike
H
Schrinner
Marc
M
Lück
Christian
C
Pich
Andrij
A
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001672:Biocompatible Materials / Q000737:chemistry; D002209:Caprolactam / Q000737:chemistry; D015169:Colony Count, Microbial; D004852:Epoxy Compounds / Q000737:chemistry; D005782:Gels / Q000737:chemistry* / Q000494:pharmacology; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry*; D008689:Methacrylates / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012834:Silver / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000187:drug effects; D014753:Vinyl Compounds / Q000737:chemistry
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D004852:Epoxy Compounds; D005782:Gels; D008689:Methacrylates; D014753:Vinyl Compounds; D012834:Silver; D002209:Caprolactam; C007870:glycidyl methacrylate