title: Liver failure and the need for transplantation in three patients with hepatoportal sclerosis.
abstract: Hepatoportal sclerosis (HPS) is one of the causes of noncirrhotic portal hypertension. In most patients, hepatic synthetic dysfunction does not occur; rarely they may require liver transplantation. In this study, we have reported the clinicopathologic characteristics of 3 patients diagnosed with HPS after examination of the explanted liver. Small liver volume, significant portal fibrosis, and phlebosclerosis may contribute to hepatic synthetic dysfunction in patients with HPS.
authors.affiliation: Pathology Department, Transplant Research Center, Transplantation Ward, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: B
authors.initials: B
authors.lastname: Geramizadeh
authors.forename: S A
authors.initials: SA
authors.lastname: Malek-Hosseini
authors.forename: H
authors.initials: H
authors.lastname: Salahi
authors.forename: A
authors.initials: A
authors.lastname: Bahador
authors.forename: S
authors.initials: S
authors.lastname: Nikeghbalian
mesh_terms: D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D006801:Humans; D008099:Liver / Q000033:anatomy & histology / Q000473:pathology; D008103:Liver Cirrhosis / Q000601:surgery*; D017114:Liver Failure, Acute / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects / Q000473:pathology; D008297:Male; D009929:Organ Size; D045743:Scleroderma, Diffuse / Q000473:pathology; D013163:Splenomegaly / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase