A systematic approach to biomarker discovery; preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers".
The International Society for the Biological Therapy of Cancer (iSBTc) has initiated in collaboration with the United States Food and Drug Administration (FDA) a programmatic look at innovative avenues for the identification of relevant parameters to assist clinical and basic scientists who study the natural course of host/tumor interactions or their response to immune manipulation. The task force has two primary goals: 1) identify best practices of standardized and validated immune monitoring procedures and assays to promote inter-trial comparisons and 2) develop strategies for the identification of novel biomarkers that may enhance our understating of principles governing human cancer immune biology and, consequently, implement their clinical application. Two working groups were created that will report the developed best practices at an NCI/FDA/iSBTc sponsored workshop tied to the annual meeting of the iSBTc to be held in Washington DC in the Fall of 2009. This foreword provides an overview of the task force and invites feedback from readers that might be incorporated in the discussions and in the final document.
Butterfield
Lisa H
LH
Department of Medicine, Division of Hematology Oncology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, 15213, USA. butterfieldl@upmc.edu
Disis
Mary L
ML
Fox
Bernard A
BA
Lee
Peter P
PP
Khleif
Samir N
SN
Thurin
Magdalena
M
Trinchieri
Giorgio
G
Wang
Ena
E
Wigginton
Jon
J
Chaussabel
Damien
D
Coukos
George
G
Dhodapkar
Madhav
M
Håkansson
Leif
L
Janetzki
Sylvia
S
Kleen
Thomas O
TO
Kirkwood
John M
JM
Maccalli
Cristina
C
Maecker
Holden
H
Maio
Michele
M
Malyguine
Anatoli
A
Masucci
Giuseppe
G
Palucka
A Karolina
AK
Potter
Douglas M
DM
Ribas
Antoni
A
Rivoltini
Licia
L
Schendel
Dolores
D
Seliger
Barbara
B
Selvan
Senthamil
S
Slingluff
Craig L
CL
Stroncek
David F
DF
Streicher
Howard
H
Wu
Xifeng
X
Zeskind
Benjamin
B
Zhao
Yingdong
Y
Zocca
Mai-Britt
MB
Zwierzina
Heinz
H
Marincola
Francesco M
FM
D015415:Biomarkers; D002986:Clinical Trials as Topic; D004493:Education; D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D015203:Reproducibility of Results; D012106:Research / Q000191:economics; D012107:Research Design; D014481:United States; D014486:United States Food and Drug Administration
D015415:Biomarkers