title: Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging.
abstract: We have combined Fourier-domain optical coherence tomography (FD-OCT) with a closed-loop adaptive optics (AO) system using a Hartmann-Shack wavefront sensor and a bimorph deformable mirror. The adaptive optics system measures and corrects the wavefront aberration of the human eye for improved lateral resolution (~4 μm) of retinal images, while maintaining the high axial resolution (~6 μm) of stand alone OCT. The AO-OCT instrument enables the three-dimensional (3D) visualization of different retinal structures in vivo with high 3D resolution (4×4×6 μm). Using this system, we have demonstrated the ability to image microscopic blood vessels and the cone photoreceptor mosaic.
authors.affiliation: Department of Ophthalmology and Vision Science, UC Davis, 4860 Y Street, Suite 2400, Sacramento, California 95817 rjzawadzki@ucdavis.edu.
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Zawadzki
authors.forename: Steven M
authors.initials: SM
authors.lastname: Jones
authors.forename: Scot S
authors.initials: SS
authors.lastname: Olivier
authors.forename: Mingtao
authors.initials: M
authors.lastname: Zhao
authors.forename: Bradley A
authors.initials: BA
authors.lastname: Bower
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Izatt
authors.forename: Stacey
authors.initials: S
authors.lastname: Choi
authors.forename: Sophie
authors.initials: S
authors.lastname: Laut
authors.forename: John S
authors.initials: JS
authors.lastname: Werner