Effects of compounds isolated from the fruits of Rumex japonicus on the protein glycation.
An anthraquinone, emodin (1), and five flavonoids, kaempferol-3-O-beta-D-glucoside (2), quercetin (3), quercitrin (4), isoquercitrin (5), and (+)-catechin (6), were isolated from an AcOEt-soluble extract of the fruits of Rumex japonicus. Their structures were determined by spectroscopic data interpretation. All the isolates were evaluated for their potential to inhibit AGEs (advanced glycation end products) formation and AGEs cross-linking, and to break already formed AGEs cross-links.
Jang
Dae Sik
DS
Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, Daejeon, Korea.
Kim
Jong Min
JM
Kim
Junghyun
J
Yoo
Jeong Lim
JL
Kim
Young Sook
YS
Kim
Jin Sook
JS
D000085:Acetates / Q000737:chemistry; D005638:Fruit / Q000737:chemistry*; D017127:Glycation End Products, Advanced / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D019664:Polygonaceae / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry
D000085:Acetates; D017127:Glycation End Products, Advanced; D011506:Proteins; D012710:Serum Albumin, Bovine; C007650:ethyl acetate