title: Skull fracture, with or without clinical signs, in mTBI is an independent risk marker for neurosurgically relevant intracranial lesion: a cohort study.
abstract: OBJECTIVE
  To explore the possibility of identifying skull fracture, with or without clinical signs, as a predictor of positive CT scans in mild traumatic brain injury (mTBI).
  
  
  METHODS
  Prospective cohort study, matched 1:1 for five potential confounding variables (age, sex, symptoms, mechanism of injury and extracranial trauma severity).
  
  
  METHODS
  The study was performed on patients with mTBI (Glasgow Coma Scale 15-14), with or without radiologically demonstrated skull fracture. The cohort with skull fracture included 155 patients selected from a sample of 5097 mTBI patients treated during 1998 at the Critical Care and Emergency Department of the Trauma Centre. The cohort without skull fracture was prospectively recruited from patients with mTBI treated in the same department from 2002-2005.
  
  
  RESULTS
  The percentage of patients with intracranial lesion (IL) was significantly higher in mTBI patients with skull fracture than in those without. The risk of requiring neurosurgery was 5-fold higher when skull fracture was present. Of mTBI patients with skull fracture and IL, 63.2% showed no clinical signs of bone injury.
  
  
  CONCLUSIONS
  Skull fracture, with or without clinical signs, in mTBI patients is associated with an increased risk of neurosurgically-relevant intracranial lesion.
authors.affiliation: Critical Care and Emergency Department, Virgen del Rocío University Hospital, Seville, Spain. angeles.munoz.sspa@juntadeandalucia.es
authors.forename: M A
authors.initials: MA
authors.lastname: Muñoz-Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Murillo-Cabezas
authors.forename: A
authors.initials: A
authors.lastname: Cayuela-Domínguez
authors.forename: M D
authors.initials: MD
authors.lastname: Rincón-Ferrari
authors.forename: R
authors.initials: R
authors.lastname: Amaya-Villar
authors.forename: J
authors.initials: J
authors.lastname: León-Carrión
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D002648:Child; D015331:Cohort Studies; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D020300:Intracranial Hemorrhages / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012887:Skull Fractures / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult