Drug-drug interactions with newer antiretroviral agents.
Knowledge of drug interactions among antiretroviral agents and other drugs used by HIV-infected patients is essential to maintaining safety and efficacy of drug treatment. Often, the clinical impact of drug-drug interactions cannot be predicted on the basis of pharmacokinetic interactions alone, highlighting the need for studies and analyses that provide exposure-response data. Drug interactions in HIV-infected patients can be complex and sometimes counterintuitive, and practitioners must increasingly rely on a concerted approach to gathering information on drug interactions that goes beyond studies showing exposure changes for coadministered drugs.
Aberg
Judith A
JA
New York University School of Medicine and Bellevue Hospital Center, New York, NY, USA.
D000328:Adult; D044966:Anti-Retroviral Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D044966:Anti-Retroviral Agents