title: Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI).
abstract: Distributions of proton MR-detected metabolites have been mapped throughout the brain in a group of normal subjects using a volumetric MR spectroscopic imaging (MRSI) acquisition with an interleaved water reference. Data were processed with intensity and spatial normalization to enable voxel-based analysis methods to be applied across a group of subjects. Results demonstrate significant regional, tissue, and gender-dependent variations of brain metabolite concentrations, and variations of these distributions with normal aging. The greatest alteration of metabolites with age was observed for white-matter choline and creatine. An example of the utility of the normative metabolic reference information is then demonstrated for analysis of data acquired from a subject who suffered a traumatic brain injury. This study demonstrates the ability to obtain proton spectra from a wide region of the brain and to apply fully automated processing methods. The resultant data provide a normative reference for subsequent utilization for studies of brain injury and disease.
authors.affiliation: Department of Radiology, Miller School of Medicine, University of Miami, Miami, Florida 33136, USA. AMaudsley@med.miami.edu
authors.forename: A A
authors.initials: AA
authors.lastname: Maudsley
authors.forename: C
authors.initials: C
authors.lastname: Domenig
authors.forename: V
authors.initials: V
authors.lastname: Govind
authors.forename: A
authors.initials: A
authors.lastname: Darkazanli
authors.forename: C
authors.initials: C
authors.lastname: Studholme
authors.forename: K
authors.initials: K
authors.lastname: Arheart
authors.forename: C
authors.initials: C
authors.lastname: Bloomer
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging / Q000378:metabolism* / Q000473:pathology; D000465:Algorithms; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D002794:Choline / Q000032:analysis*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D055815:Young Adult
chemical_list: D011522:Protons; D002794:Choline