Bupropion-associated QRS prolongation unresponsive to sodium bicarbonate therapy.
We describe a case of bupropion-associated QRS prolongation that was unresponsive to intravenous bolus therapy of sodium bicarbonate. Bupropion may cause seizures and conduction delays similar to tricyclic antidepressants in the overdose setting by an unknown mechanism.
Wills
Brandon K
BK
Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, WA, USA.
Zell-Kanter
Michele
M
Aks
Steven E
SE
D000931:Antidotes / Q000627:therapeutic use; D016642:Bupropion / Q000506:poisoning*; D018765:Dopamine Uptake Inhibitors / Q000506:poisoning*; D062787:Drug Overdose; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D017211:Treatment Failure
D000931:Antidotes; D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D017693:Sodium Bicarbonate