Synthesis of imidazol-1-yl-acetic acid hydrochloride: a key intermediate for zoledronic acid.
A convenient and practical synthesis of imidazol-1-yl-acetic acid hydrochloride was achieved via N-alkylation of imidazole using tert-butyl chloroacetate followed by a non-aqueous ester cleavage of the resulting imidazol-1-yl-acetic acid tert-butyl ester in the presence of titanium tetrachloride. The synthesized imidazol-1-yl-acetic acid hydrochloride was then utilized to prepare zoledronic acid.
Singh
Santosh Kumar
SK
New Drug Discovery, Matrix Laboratories Limited, Anrich Industrial Estate, Bollaram, Jinnaram Mandal, Medak District, Andhra Pradesh, India-502 325. sksingh_p2@rediffmail.com
Manne
Narendra
N
Ray
Purna Chandra
PC
Pal
Manojit
M