title: Circulating proinflammatory cytokines and N-terminal pro-brain natriuretic peptide significantly decrease with recovery of left ventricular function in patients with dilated cardiomyopathy.
abstract: BACKGROUND
  Increased levels of TNF-alpha, IL-6, their soluble receptors, and NT-proBNP have been observed in patients with dilated cardiomyopathy (DCM). In the present study, we assessed the possible involvement of proinflammatory cytokines and their soluble receptors with and without recovery of LV function in DCM patients.
  
  
  RESULTS
  Forty patients with DCM were enrolled and divided into two groups: Group I consisted of DCM patients (n = 30) whose left ventricular ejection fraction (LVEF) had not recovered on follow up and Group II comprised DCM patients (n = 10) whose LVEF had recovered. Ten healthy subjects were included as controls (Group III). TNF-alpha, IL-6,TNFR1, TNFRII, gp130, and NT-proBNP levels were significantly increased in Group I and were significantly lower in patients with LVEF recovery as compared to those without recovery of LVEF (P < 0.05).
  
  
  CONCLUSIONS
  Circulating TNF-alpha, IL-6, and NT-proBNP appear to correlate with the LV function recovery of patients with DCM and could be used as prognostic biomarkers.
authors.affiliation: Department of Cardiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Shamim
authors.initials: S
authors.lastname: Ahmad
authors.forename: Parminder Singh
authors.initials: PS
authors.lastname: Otaal
authors.forename: Taranjit Singh
authors.initials: TS
authors.lastname: Rai
authors.forename: Ajay
authors.initials: A
authors.lastname: Bahl
authors.forename: Uma Nahar
authors.initials: UN
authors.lastname: Saikia
authors.forename: Rohit K
authors.initials: RK
authors.lastname: Manoj
authors.forename: M
authors.initials: M
authors.lastname: Thungapathra
authors.forename: Kewal K
authors.initials: KK
authors.lastname: Talwar
authors.forename: Madhu
authors.initials: M
authors.lastname: Khullar
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000175:diagnosis*; D016022:Case-Control Studies; D050822:Cytokine Receptor gp130 / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain; D010446:Peptide Fragments; D011379:Prognosis; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D016277:Ventricular Function, Left; D055815:Young Adult
chemical_list: D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D010446:Peptide Fragments; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D050822:Cytokine Receptor gp130