[An experimental study on cardiopulmonary resuscitation by cardiac massage under diaphragmatic muscle for rabbit with cardiac arrest].
OBJECTIVE
To compare the hemodynamic effect of standard-cardiopulmonary resuscitation (S-CPR) and of CPR by cardiac massage under the diaphragmatic muscle (D-CPR), and to evaluate the feasibility of D-CPR.


METHODS
Twenty healthy New Zealand rabbits were randomly divided into two groups: one group receiving S-CPR (n=10) and the other group receiving D-CPR (n=10). Cardiac arrest was induced by asphyxiation at the end expiration for 8 minutes. After the hemodynamic situation was stable for 5 minutes before asphyxiation, the readings of ascending aorta systolic pressure (AOS) and diastolic pressure (AOD), transcutaneous oxygen saturation (SpO(2)), right atrial systolic pressure (RASP), right atrial diastolic pressure (RADP), and electrocardiogram were recorded consecutively to the end of the experiment . The mean arterial pressure (MAP) of ascending aorta and coronary perfusion pressure (CPP) were calculated. The rate of restoration of spontaneous circulation (ROSC) and the survival rate in a short duration of 6 hours were observed.


RESULTS
Five rabbits in S-CPR group and 8 in D-CPR group were successfully resuscitated and obtained ROSC (50%, 80%, P=20.05). Six hours survival rate was 40% in S-CRP group and 50% in D-CPR group. The comparisons between the two groups on AOS, AOD, MAP and CPP respectively showed that at 1 minute and 5 minutes during resuscitation the respective variables were higher in the D-CPR group than that in the S-CPR group (all P<0.05). Compared to the hemodynamics before asphyxiation, the MAP and CPP in the D-CPR group increased 54.1% and 33.4% of basic value at 1 minute, and they were 60.0% and 41.8% at 5 minutes, while the AOS and AOD in the S-CPR group only increased by an average of 37.3% and 16.5% at 1 minute, and they were 38.5% and 17.1% at 5 minutes, respectively. After ROSC, the hemodynamic variations of the D-CPR rabbits were more stable than those of S-CPR rabbits.


CONCLUSIONS
D-CPR can provide higher arterial pressure, cardiac output, rate of ROSC and survival rate in a short period than S-CPR can induce, so that D-CPR is superior to S-CPR.
Wang
Li-Xiang
LX
Department of Emergency Medicine, General Hospital of Armed Police Forces, Beijing 100039, China.
Ding
Chun-Xia
CX
Li
Xu
X
Gu
Cai-Hong
CH
Sun
Kun
K
Liu
Ya-Hua
YH
D000818:Animals; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004195:Disease Models, Animal; D005240:Feasibility Studies; D006323:Heart Arrest / Q000628:therapy*; D006336:Heart Massage / Q000379:methods*; D011817:Rabbits; D011897:Random Allocation