title: [Study on the prevalence rate and immunity of hepatitis B virus infection among urban adults aged over 20 years in Wuxi, Jiangsu province].
abstract: OBJECTIVE
  To study the relationship on the prevalence rate of hepatitis B virus (HBV) infection and hepatitis B vaccination in urban citizens aged over 20 years old which would led to the development of strategies on HBV control.
  
  
  METHODS
  A total of 3744 subjects from general population were randomly selected in this study. Both ELISA and radio immunoassay were used to test five items of HBV infection, including HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc.
  
  
  RESULTS
  The overall standardized infection rate of HBV was 51.7%, and HBsAg, anti-HBs, HBeAg, anti-HBe and anti-HBc were 4.5%, 48.5%, 0.3%, 3.5% and 51.4%, respectively. The two lowest HBsAg positive rates were found in the groups under 30 years old (2.9%) and students (2.6%). Anti-HBc rate among men was significantly higher than seen in women (P < 0.05), and showing a trend of increase with age (chi2 for trend = 256.2, P < 0.001). The standardized rates of HB vaccination in this population was 17.6% and decreasing rapidly with age (P < 0.05). People who had been vaccinated had both lower rates of HBsAg and HBV infection but higher rate of anti-HBs than those who had not (P < 0.05).
  
  
  CONCLUSIONS
  HB vaccination in adults showed a reducing rate of HBV infection in the general population. Together with the enhancement of expanded program on immunization towards HB vaccination in neonates, much attention should be paid to HB vaccination in adults.
authors.affiliation: Wuxi Center for Disease Control and Prevention, Wuxi 214023, China.
authors.forename: Yan-hua
authors.initials: YH
authors.lastname: Qian
authors.forename: Yu-di
authors.initials: YD
authors.lastname: Lin
authors.forename: Hong-bing
authors.initials: HB
authors.lastname: Shen
authors.forename: Mei-hua
authors.initials: MH
authors.lastname: Dong
authors.forename: Yu
authors.initials: Y
authors.lastname: Deng
authors.forename: Xiao-lan
authors.initials: XL
authors.lastname: Miao
authors.forename: Xu-wen
authors.initials: XW
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Gu
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Rong-bin
authors.initials: RB
authors.lastname: Yu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006509:Hepatitis B / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
chemical_list: D017325:Hepatitis B Vaccines