Reversion of influenza A (H3N2) virus from amantadine resistant to amantadine sensitive by further reassortment in Japan during the 2006-to-2007 influenza season.
In the 2006-to-2007 influenza season, amantadine-sensitive strains were found among the N-lineage influenza A (H3N2) viruses, which were previously believed to be associated with amantadine resistance. Whole-genome sequencing results indicated that this was due to a further reassortment event.
Furuse
Yuki
Y
Tohoku University Graduate School of Medicine, Aoba-ku, Sendai 980-8575, Japan. furusey@mail.tains.tohoku.ac.jp
Suzuki
Akira
A
Kamigaki
Taro
T
Shimizu
Midori
M
Fuji
Naoko
N
Oshitani
Hitoshi
H
D000547:Amantadine / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D016679:Genome, Viral; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000235:genetics*; D007251:Influenza, Human / Q000821:virology*; D007564:Japan; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics; D016865:Reassortant Viruses / Q000187:drug effects* / Q000235:genetics*; D017422:Sequence Analysis, DNA
D000998:Antiviral Agents; D012367:RNA, Viral; D000547:Amantadine