Self-perception of side effects by adolescents in a chlorhexidine-fluoride-based preventive oral health program.
OBJECTIVE
The objective of this study was to evaluate the incidence of adverse effects reported by adolescents following 14 days of use of a mouthrinse containing 0.05% NaF+0.12% chlorhexidine.


METHODS
This double-blind study was developed as part of a randomized clinical trial. The adolescents enrolled to the study were randomly divided into two groups to use either: 0.05% NaF+0.12% chlorhexidine (G1, n=85) or 0.05% NaF (G2, n=85). Both groups used a 10mL solution of the mouthwash during 1 minute daily for 2 weeks under supervision. After that period, the subject's acceptance of taste was measured using a verbal descriptive scale (Labeled Magnitude Scale - LMS). Participants were also interviewed regarding the occurrence of possible adverse effects during treatment (temporary palate disorders, tooth staining or unpleasant taste). The proportional differences between the groups were tested using the chi-square test.


RESULTS
Palate changes were reported by 26% of participants of each group; 17.7% of G1 and 32% of G2 reported an unpleasant taste (p = 0.062), while staining was reported by 55% of G1 and 68.9% of G2 (p = 0.117). Absenteeism rates were similar in both groups (G1= 2.58 +/- 2.69; G2=2.81 +/- 2.39), p=0.362.


CONCLUSIONS
Adherence was high in both groups and side effects reported by subjects were not perceived by them as being important. Since subjects' acceptance and compliance is fundamental to the success of an oral health program, chlorhexidine-fluoride could be a useful resource in a program of plaque control.
Guimaraes
Ana Rita Duarte
AR
Department of Stomatology, Federal University of Santa Catarina. ardg1999@gmail.com
Peres
Marco Aurélio
MA
Vieira
Ricardo de Sousa
Rde S
Ferreira
Rodrigo Melin
RM
Ramos-Jorge
Maria Letícia
ML
Apolinario
Sara
S
Debom
Anderson
A