title: Literature-curated protein interaction datasets.
abstract: High-quality datasets are needed to understand how global and local properties of protein-protein interaction, or 'interactome', networks relate to biological mechanisms, and to guide research on individual proteins. In an evaluation of existing curation of protein interaction experiments reported in the literature, we found that curation can be error-prone and possibly of lower quality than commonly assumed.
authors.affiliation: Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA. michael_cusick@dfci.harvard.edu
authors.forename: Michael E
authors.initials: ME
authors.lastname: Cusick
authors.forename: Haiyuan
authors.initials: H
authors.lastname: Yu
authors.forename: Alex
authors.initials: A
authors.lastname: Smolyar
authors.forename: Kavitha
authors.initials: K
authors.lastname: Venkatesan
authors.forename: Anne-Ruxandra
authors.initials: AR
authors.lastname: Carvunis
authors.forename: Nicolas
authors.initials: N
authors.lastname: Simonis
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Rual
authors.forename: Heather
authors.initials: H
authors.lastname: Borick
authors.forename: Pascal
authors.initials: P
authors.lastname: Braun
authors.forename: Matija
authors.initials: M
authors.lastname: Dreze
authors.forename: Jean
authors.initials: J
authors.lastname: Vandenhaute
authors.forename: Mary
authors.initials: M
authors.lastname: Galli
authors.forename: Junshi
authors.initials: J
authors.lastname: Yazaki
authors.forename: David E
authors.initials: DE
authors.lastname: Hill
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Ecker
authors.forename: Frederick P
authors.initials: FP
authors.lastname: Roth
authors.forename: Marc
authors.initials: M
authors.lastname: Vidal
mesh_terms: D000818:Animals; D016208:Databases, Factual; D030562:Databases, Protein; D006801:Humans; D011485:Protein Binding; D011506:Proteins / Q000032:analysis / Q000737:chemistry / Q000378:metabolism*; D015203:Reproducibility of Results; D012107:Research Design
chemical_list: D011506:Proteins