Cation-pi interactions at the active site of factor Xa: dramatic enhancement upon stepwise N-alkylation of ammonium ions.
Salonen
Laura M
LM
Laboratorium für Organische Chemie, ETH Zürich, Hönggerberg, HCI, 8093 Zürich, Switzerland.
Bucher
Christoph
C
Banner
David W
DW
Haap
Wolfgang
W
Mary
Jean-Luc
JL
Benz
Jörg
J
Kuster
Olivier
O
Seiler
Paul
P
Schweizer
W Bernd
WB
Diederich
François
F
D000478:Alkylation; D000814:Aniline Compounds / Q000737:chemistry*; D020134:Catalytic Domain; D002412:Cations / Q000737:chemistry; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry; D015951:Factor Xa / Q000737:chemistry*; D065427:Factor Xa Inhibitors; D008024:Ligands; D000644:Quaternary Ammonium Compounds / Q000737:chemistry*; D013816:Thermodynamics
D000814:Aniline Compounds; D002412:Cations; D004791:Enzyme Inhibitors; D065427:Factor Xa Inhibitors; D008024:Ligands; D000644:Quaternary Ammonium Compounds; D015951:Factor Xa