Ki67 and salivary cancer.
We examined Ki67 expression in salivary malignancies of 75 patients with a follow-up period of up to 20 years. Correlations between enhanced Ki67 and enhanced p53 and TUNEL and heparanase staining levels were significant. Median survival for reduced-stained-tumor patients (< or = 5%) was 163 months, dropping significantly to 39 months (p = 0.0005) for enhanced stained tumors (> 5%); 5 year survival probability was 93% and 33%, respectively, 45% and 16%, respectively, (p = 0.0005) at 20 years. Significant correlation between poor survival and concurrently altered expression rates of Ki67 and p53, p27 Skp2, TUNEL and heparanase in the salivary malignancies indicates a biological role in salivary cancer pathogenesis.
Ben-Izhak
Ofer
O
Department of Pathology, Rambam Medical Center, Haifa, Israel.
Akrish
Sharon
S
Nagler
Rafael M
RM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000145:classification / Q000235:genetics / Q000473:pathology; D002455:Cell Division; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011336:Probability; D012333:RNA, Messenger / Q000235:genetics; D044786:S-Phase Kinase-Associated Proteins / Q000235:genetics; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D055815:Young Adult
D019394:Ki-67 Antigen; D012333:RNA, Messenger; D044786:S-Phase Kinase-Associated Proteins; D016159:Tumor Suppressor Protein p53