A new function for the RNA-editing enzyme ADAR1.
ADAR1 catalyzes the deamination of adenosine to inosine in double-stranded RNA. This RNA-editing enzyme is now shown to be involved in hematopoiesis, where it acts to suppress interferon signaling and to block premature apoptosis.
Iizasa
Hisashi
H
Department of Gene Expression and Regulation, Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
Nishikura
Kazuko
K
D000243:Adenosine Deaminase / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D015536:Down-Regulation; D006410:Hematopoiesis / Q000235:genetics*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D007372:Interferons / Q000378:metabolism*; D054503:Lymphoid Progenitor Cells / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D017393:RNA Editing; D016601:RNA-Binding Proteins
D016601:RNA-Binding Proteins; D007372:Interferons; C567955:ADARB1 protein, human; D000243:Adenosine Deaminase