title: Case report: a case of pyoderma gangrenosum with intractable leg ulcers treated by allogeneic cultured dermal substitutes.
abstract: Pyoderma gangrenosum (PG) is an idiopathic, inflammatory, ulcerative disease of undetermined cause. Both topical and systemic treatments of corticosteroids and cyclosporine are commonly used for the ulcers of PG, but these ulcers are often intractable despite treatment. We employed allogeneic cultured dermal substitutes (CDS) in a patient with intractable ulcers due to PG. The CDS was prepared by cultured human fibroblasts on two-layered sponges of extracellular matrix such as hyaluronic acid and atelo-collagen. In the present case, re-epithelization and healthy granulation were induced by the CDS without increasing the dosage of systemic prednisolone. Then the subsequent autologous skin graft was successfully performed. This indicates that CDS is one of the useful tools for the treatment of intractable ulcers in patients with PG.
authors.affiliation: Department of Dermatology, Wakayama Medical University, Wakayama, Japan. seikotoy@wakayama-med.ac.jp
authors.forename: Seiko
authors.initials: S
authors.lastname: Toyozawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nishide
authors.forename: Akiko
authors.initials: A
authors.lastname: Kishioka
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kanazawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Yoshimitsu
authors.initials: Y
authors.lastname: Kuroyanagi
authors.forename: Fukumi
authors.initials: F
authors.lastname: Furukawa
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy; D002478:Cells, Cultured / Q000637:transplantation; D003131:Combined Modality Therapy; D003646:Debridement; D005260:Female; D005347:Fibroblasts / Q000637:transplantation*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007871:Leg Ulcer / Q000382:microbiology / Q000601:surgery*; D011239:Prednisolone / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000150:complications / Q000382:microbiology; D017511:Pyoderma Gangrenosum / Q000150:complications / Q000601:surgery*; D016038:Skin Transplantation; D017768:Skin, Artificial; D015503:Surgical Sponges; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014945:Wound Healing
chemical_list: D007166:Immunosuppressive Agents; D011239:Prednisolone