title: Evolution of central nervous system multidrug-resistant Mycobacterium tuberculosis and late relapse of cryptic prosthetic hip joint tuberculosis: complications during treatment of disseminated isoniazid-resistant tuberculosis in an immunocompromised host.
abstract: We report a case of disseminated isoniazid-resistant tuberculosis in an immunocompromised patient with evolution of rifampin (rifampicin) resistance in the central nervous system. This was cured with intraventricular and oral treatment but was followed by a late relapse of the original infection in a prosthetic hip joint. We provide drug levels in cerebrospinal fluid and serum.
authors.affiliation: Clinical Microbiology, Auckland City Hospital, Auckland, New Zealand.
authors.forename: Arlo
authors.initials: A
authors.lastname: Upton
authors.forename: Andrew
authors.initials: A
authors.lastname: Woodhouse
authors.forename: Ross
authors.initials: R
authors.lastname: Vaughan
authors.forename: Sandie
authors.initials: S
authors.lastname: Newton
authors.forename: Rod
authors.initials: R
authors.lastname: Ellis-Pegler
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000032:analysis / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000737:chemistry; D006621:Hip Joint / Q000382:microbiology; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification*; D016459:Prosthesis-Related Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D012008:Recurrence; D044967:Serum / Q000737:chemistry; D014390:Tuberculosis, Meningeal / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents