Fospropofol assay issues and impact on pharmacokinetic and pharmacodynamic evaluation.
Shah
Ajit
A
Mistry
Bipin
B
Gibiansky
Ekaterina
E
Gibiansky
Leonid
L
D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001681:Biological Assay / Q000379:methods*; D001711:Biotransformation; D004355:Drug Stability; D006461:Hemolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D011355:Prodrugs / Q000008:administration & dosage / Q000493:pharmacokinetics*; D015742:Propofol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012995:Solubility; D014638:Vanadates / Q000737:chemistry
D018686:Anesthetics, Intravenous; D011355:Prodrugs; D014638:Vanadates; C472965:fospropofol; D015742:Propofol