title: Heparin leak from a hemodialysis catheter causing major bleeding, ultimately leading to transplant rejection and death.
abstract: Leakage of hemodialysis catheter-locking solutions into the circulation has been reported in in vitro and in vivo studies, although there have been few reports of serious clinical adverse events. We describe a case of heparin leak from a hemodialysis catheter, which caused significant clinical bleeding requiring multiple transfusions and may have ultimately been responsible for the patient's death after transplantation.
authors.affiliation: Department of Nephrology, Royal London Hospital, London, UK. gavin_dreyer@hotmail.com
authors.forename: Gavin
authors.initials: G
authors.lastname: Dreyer
authors.forename: Paul
authors.initials: P
authors.lastname: Lawton
authors.forename: Matthew
authors.initials: M
authors.lastname: Jose
mesh_terms: D000925:Anticoagulants / Q000493:pharmacokinetics; D002404:Catheterization / Q000009:adverse effects*; D004868:Equipment Failure; D017809:Fatal Outcome; D005260:Female; D006084:Graft Rejection / Q000209:etiology; D006493:Heparin / Q000493:pharmacokinetics*; D006801:Humans; D007601:Jugular Veins; D007676:Kidney Failure, Chronic / Q000601:surgery / Q000628:therapy*; D016030:Kidney Transplantation; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000139:chemically induced*; D006435:Renal Dialysis
chemical_list: D000925:Anticoagulants; D006493:Heparin