title: Myocardial protection with enalaprilat in patients unresponsive to ischemic preconditioning during percutaneous coronary intervention.
abstract: Cardioprotection due to angiotensin enzyme inhibitors is attributed, at least in part, to the inhibition of bradykinin breakdown and the preconditioning effect of the elevated endogenous bradykinin level. We have previously shown that in patients undergoing percutaneous coronary intervention, one 120-second balloon inflation is insufficient to precondition the heart. The objective of the present study was to examine whether the administration of enalaprilat to these patients results in protection. Twenty patients underwent two 120-second coronary artery occlusions separated by a reperfusion interval of 10 min. Ten patients were given 50 microg x min-1 enalaprilat in an intracoronary infusion between the balloon inflations, whereas the others received an infusion of saline. In the latter control patients, there were no significant differences in ST-segment elevation between the consecutive occlusions (peak ST: 1.61 +/- 0.17 vs. 1.61 +/- 0.16 mV; time to reach 0.5 mV ST elevation: 16 +/- 4 vs. 22 +/- 7 s; mean ST: 1.03 +/- 0.12 vs. 1.02 +/- 0.11 mV). In the patients who received enalaprilat before the second balloon inflation, the ST-segment elevation was significantly less pronounced and slower during the second inflation than during the first (peak ST: 1.80 +/- 0.18 vs. 1.41 +/- 0.19 mV; time to reach 0.5 mV ST elevation: 18 +/- 4 vs. 30 +/- 4 s; mean ST: 1.04 +/- 0.11 vs. 0.85 +/- 0.14 mV). We conclude that enalaprilat administered during percutaneous coronary intervention provides protection to patients who do not have a protective response to the initial balloon inflation.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Albert Szent-Gyorgyi Clinical Center, University of Szeged, H-6720, Pecsi Street 4, Szeged, Hungary.
authors.forename: Imre
authors.initials: I
authors.lastname: Ungi
authors.forename: Attila
authors.initials: A
authors.lastname: Pálinkás
authors.forename: Attila
authors.initials: A
authors.lastname: Nemes
authors.forename: Tamás
authors.initials: T
authors.lastname: Ungi
authors.forename: Attila
authors.initials: A
authors.lastname: Thury
authors.forename: Róbert
authors.initials: R
authors.lastname: Sepp
authors.forename: Tamás
authors.initials: T
authors.lastname: Horváth
authors.forename: Tamás
authors.initials: T
authors.lastname: Forster
authors.forename: Agnes
authors.initials: A
authors.lastname: Végh
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D015773:Enalaprilat / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D015773:Enalaprilat