title: Anxiety-like behaviors in mice lacking GIT2.
abstract: G protein-coupled receptor kinase-interactor 2 (GIT2) is a signaling scaffold protein that also functions as GTPase-activating protein (GAPs) for ADP-ribosylation factor (Arf) small GTP-binding proteins. GIT2 has been implicated in the regulation of G protein-coupled receptor trafficking and cell adhesion and migration. To evaluate possible neurobehavioral functions of GIT2 in vivo, we evaluated GIT2-knockout (KO) mice for abnormalities in emotionality and mood. Male and female GIT2-KO mice presented with anxiety-like behaviors in the zero-maze and light-dark emergence tests. Immobility times in tail suspension were reduced in GIT2-KO males, but were normal in GIT2-KO females. Hence, GIT2-KO mice display anxiety-like behavior in an absence of depressive-like responses.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Robert
authors.initials: R
authors.lastname: Schmalzigaug
authors.forename: Ramona M
authors.initials: RM
authors.lastname: Rodriguiz
authors.forename: Lindsey E
authors.initials: LE
authors.lastname: Phillips
authors.forename: Collin E
authors.initials: CE
authors.lastname: Davidson
authors.forename: William C
authors.initials: WC
authors.lastname: Wetsel
authors.forename: Richard T
authors.initials: RT
authors.lastname: Premont
mesh_terms: D000818:Animals; D001008:Anxiety Disorders / Q000235:genetics* / Q000378:metabolism* / Q000503:physiopathology; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D018797:Cell Cycle Proteins / Q000235:genetics*; D003866:Depressive Disorder / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D020690:GTPase-Activating Proteins; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009483:Neuropsychological Tests; D010750:Phosphoproteins / Q000235:genetics*; D012727:Sex Characteristics; D015398:Signal Transduction / Q000235:genetics
chemical_list: D018797:Cell Cycle Proteins; D020690:GTPase-Activating Proteins; C120767:Git2 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D010750:Phosphoproteins