title: Rosiglitazone, a peroxisome proliferator-activated receptor gamma (PPARgamma)-specific agonist, as a modulator in experimental acute pancreatitis.
abstract: BACKGROUND
  The purpose of this experiment was to investigate the role of PPAR ligands in the course of inflammation and of rosiglitazone, a PPAR-gamma-specific agonist, on the course of experimental acute pancreatitis (EAP).
  
  
  METHODS
  EAP was induced by administration of 5% sodium taurocholate injected into the pancreatic duct. The inflammatory activity was evaluated by biochemical scores (alpha-amylase, lipase, aminotransferases, and bilirubin), morphological changes (determined by light microscopy, H+E stained), and immunohistochemical reactions (ICAM, nitrotyrosine).
  
  
  RESULTS
  Rosilgitazone administered in the course of EAP at a dose 50 mg/kg p.o. decreased the intensity of morphological changes (edema, inflammatory infiltrates, necrosis, and erythrocyte extravasations). In the rosiglitazone-treated animals all the biochemical parameters of EAP were statistically significantly decreased. Immunohistochemical reactions against ICAM-1 and nitrotyrosine showed that rosiglitazone decreased the intensity of inflammatory reactions in the groups of treated animals.
  
  
  CONCLUSIONS
  PPAR-gamma agonists modulate the course of the inflammatory reaction. The administration of rosiglitazone decreased the intensity of the inflammatory process in the course of sodium taurocholate-induced EAP.
authors.affiliation: Department of Gastroenterology with Endoscopic Unit, Medical University, Lublin, Poland. celinski@mp.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Celiński
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Madro
authors.forename: Beata
authors.initials: B
authors.lastname: Prozorow-Król
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Korolczuk
authors.forename: Halina
authors.initials: H
authors.lastname: Cichoz-Lach
authors.forename: Maria
authors.initials: M
authors.lastname: Słomka
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Korobowicz
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000097:blood; D007150:Immunohistochemistry; D008049:Lipase / Q000097:blood; D047495:PPAR gamma / Q000819:agonists*; D019283:Pancreatitis, Acute Necrotizing / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D000077154:Rosiglitazone; D013656:Taurocholic Acid / Q000633:toxicity; D045162:Thiazolidinediones / Q000627:therapeutic use*; D000637:Transaminases / Q000097:blood; D000516:alpha-Amylases / Q000097:blood
chemical_list: D047495:PPAR gamma; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D013656:Taurocholic Acid; D000637:Transaminases; D008049:Lipase; D000516:alpha-Amylases; D001663:Bilirubin