title: Gender risk of nonfatal stroke in type 2 diabetic patients differs depending on the type of treatment.
abstract: BACKGROUND
  The gender differences in stroke risk among diabetic patients with different treatments have not been studied previously. We aim to determine if there is a gender difference in nonfatal stroke risk in diabetic patients receiving different types of glucose-lowering treatments.
  
  
  METHODS
  In December 2005, data of type 2 diabetic patients were extracted from a nationwide population-based diabetes registry covering 11 Ukrainian regions. Male/female odds ratios (OR) for nonfatal stroke were calculated in three treatment groups: diet only 7,273/15,901, oral glucose-lowering drugs 15,109/33,913, and insulin 5,529/12,462 male/female. Male/female ORs of stroke were estimated using a logistic regression model.
  
  
  RESULTS
  The age-adjusted ORs of stroke were higher among diabetic men compared with diabetic women with oral glucose-lowering drug treatment (OR 1.37, 95% CI 1.22-1.54) and diet treatment only (OR 1.53, 95% CI 1.35-1.73). No differences were found among patients who used insulin (OR 0.97, 95% CI 0.84-1.11). Further adjustment for duration of type 2 diabetes, body mass index (BMI), systolic blood pressure, total cholesterol, and smoking affected the results only slightly.
  
  
  CONCLUSIONS
  The gender risks of nonfatal stroke in patients with type 2 diabetes appear to differ considerably depending on treatment types.
authors.affiliation: Institute of Endocrinology and Metabolism, Kiev, Ukraine. nikhalangot@ukr.net
authors.forename: Mykola
authors.initials: M
authors.lastname: Khalangot
authors.forename: Gang
authors.initials: G
authors.lastname: Hu
authors.forename: Mykola
authors.initials: M
authors.lastname: Tronko
authors.forename: Victor
authors.initials: V
authors.lastname: Kravchenko
authors.forename: Vitaliy
authors.initials: V
authors.lastname: Guryanov
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000187:drug effects; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000178:diet therapy* / Q000188:drug therapy*; D003927:Diet, Diabetic / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000145:classification / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D016015:Logistic Models; D008297:Male; D054526:Men's Health; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology; D013997:Time Factors; D014455:Ukraine / Q000453:epidemiology; D016387:Women's Health
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin