title: Search for antimycobacterial constituents from a Tibetan medicinal plant, Gentianopsis paludosa.
abstract: From the whole plant of Gentianopsis paludosa seven compounds were isolated and identified to be 1,7-dihydroxy-3,8-dimethoxyxanthone (1), 1,7,8-trihydroxy-3-methoxyxanthone (2), 1-hydroxy-3,7,8-trimethoxyxanthone (3), 1,8-dihydroxy-2,6-dimethoxyxanthone (4), oleanolic acid (5), 4',5,7-trihydroxyflavone (6) and luteolin-7-O-glucoside (7). Compounds 1, 2, 3 and 5 showed modest inhibitory effect against the growth of Mycobacterium smegmatis and M. tuberculosis.
authors.affiliation: School of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong.
authors.forename: Ming-Fai
authors.initials: MF
authors.lastname: Yeung
authors.forename: Clara B S
authors.initials: CB
authors.lastname: Lau
authors.forename: Raphael C Y
authors.initials: RC
authors.lastname: Chan
authors.forename: Yuying
authors.initials: Y
authors.lastname: Zong
authors.forename: Chun-Tao
authors.initials: CT
authors.lastname: Che
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D029965:Gentianaceae / Q000737:chemistry*; D015394:Molecular Structure; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D018609:Tibet; D044004:Xanthones / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D010936:Plant Extracts; D044004:Xanthones