New furanoditerpenoids from Croton jatrophoides.
Four furanoditerpenoids were isolated from roots of Croton jatrophoides (Euphorbiaceae) collected in Tanzania. In addition to the known compounds penduliflaworosin and teucvin (mallotucin A), a new teucvin isomer, which was named isoteucvin, and a furanoditerpenoid with a new skeleton, for which the name jatrophoidin was adopted, were isolated. Their structures were elucidated by spectroscopic methods such as ESI-MS and NMR, including (1)H-, (13)C-, and two-dimensional NMR. The crystal structures of isoteucvin and jatrophoidin were solved using single-crystal X-ray diffraction, by which we also established the absolute configuration of jatrophoidin. The refined crystal structure of isoteucvin has the same (absolute) configuration as jatrophoidin, although the X-ray diffraction data of isoteucvin were not conclusive with respect to the absolute configuration.
Mbwambo
Zakaria H
ZH
Institute of Traditional Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Foubert
Kenne
K
Chacha
Musa
M
Kapingu
Modest C
MC
Magadula
Joseph J
JJ
Moshi
Mainen M
MM
Lemière
Filip
F
Goubitz
Kees
K
Fraanje
Jan
J
Peschar
René
R
Vlietinck
Arnold
A
Apers
Sandra
S
Pieters
Luc
L
D029802:Croton / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification; D007536:Isomerism; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots; D013636:Tanzania
D004224:Diterpenes; D005663:Furans; D010936:Plant Extracts; C539868:isoteucvin; C539869:jatrophoidin; C539815:penduliflaworosin; C407871:teucvin