title: [Sleep-disordered breathing in children].
abstract: Sleep-disordered breathing (SDB) in children comprises a wide spectrum of symptoms ranging from primary snoring to obstructive sleep apnea (OSA). Twelve percent of children present primary snoring and 1-2% OSA. Polysomnography is the gold standard for diagnosis of SDB allowing the analysis of sleep stages, respiratory movements, airflow, and gas exchange. However, this test remains highly technical, expensive, and difficult to conduct; other simpler diagnostic methods are under evaluation. Recent studies highlight the frequency and importance of cognitive and behavioral disorders in children with SDB; both the age and the severity of the SDB seem to modulate in the expression of neurocognitive consequences. Local and systemic inflammation plays a key role in the physiopathology of SDB and its complications: OSA is a cardiovascular risk factor in childhood that could favor atheromatous complications later in life. Adenoidotonsillectomy is the treatment of choice, but anti-inflammatory therapies such as leukotriene receptor antagonists or nasal corticoids may be beneficial in mild SDB or in residual OSA after adenotonsillectomy. In case of failure, noninvasive ventilation by means of nasal continuous positive pressure will be necessary, aided by specialists. SDB and OSA are a public health problem, underlining the pivotal role of the pediatrician in preventing, diagnosing, and treating these frequent disorders.
authors.affiliation: Service de génétique médicale, hôpital Necker-Enfants-Malades, AP-HP, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Cohen-Gogo
authors.forename: Ngoc Thanh C
authors.initials: NT
authors.lastname: Do
authors.forename: D
authors.initials: D
authors.lastname: Levy
authors.forename: J
authors.initials: J
authors.lastname: Métreau
authors.forename: P
authors.initials: P
authors.lastname: Mornand
authors.forename: P
authors.initials: P
authors.lastname: Parisot
authors.forename: B
authors.initials: B
authors.lastname: Fauroux
mesh_terms: D000233:Adenoidectomy; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002648:Child; D003072:Cognition Disorders / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D017286:Polysomnography; D011175:Positive-Pressure Respiration; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D014068:Tonsillectomy
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal