title: A bridge to transcription by RNA polymerase.
abstract: A comprehensive survey of single amino-acid substitution mutations critical for RNA polymerase function published in Journal of Biology supports a proposed mechanism for polymerase action in which movement of the polymerase 'bridge helix' promotes transcriptional activity in cooperation with a critical substrate-interaction domain, the 'trigger loop'.
authors.affiliation: Department of Structural Biology, Stanford University, 299 Campus Dr, West, Stanford, CA 94305, USA.
authors.forename: Craig D
authors.initials: CD
authors.lastname: Kaplan
authors.forename: Roger D
authors.initials: RD
authors.lastname: Kornberg
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D014644:Genetic Variation; D014158:Transcription, Genetic
chemical_list: D012321:DNA-Directed RNA Polymerases