Preparation and properties of cyclodextrin/PNIPAm microgels.
A two-stage precipitation polymerization in aqueous solution was used to prepare beta-cyclodextrin/poly(N-isopropylacrylamide) (beta-CD/PNIPAm) core-shell microgels. At the first stage, core microgels with CD moieties were synthesized by precipitation copolymerization of N-isopropylacrylamide (NIPAm) with a monovinyl beta-CD monomer. At the second stage, using the core particles as seeds, PNIPAm shell were further added onto the seeds by NIPAm polymerization. The microgels were characterized by means of Zetasizer Nano-ZS dynamic light scattering, TEM, IR, NMR, DSC, and TGA measurements. Using paeonol as a model drug molecule, the release behaviors of the microgels were investigated. The result indicates that the core-shell microgels could respond to change in temperature. Furthermore, the release of paeonol was related to supramolecular inclusion behavior of beta-CD and temperature sensitivity of PNIPAm.
Liu
Yu-Yang
YY
Department of Applied Chemistry, School of Science, Northwestern Polytechnical University, Xi'an, PR China. yyliu666@yahoo.com.cn
Yu
Yu
Y
Tian
Wei
W
Sun
Le
L
Fan
Xiao-Dong
XD
D000180:Acrylic Resins / Q000737:chemistry*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D016503:Drug Delivery Systems; D005782:Gels / Q000138:chemical synthesis / Q000737:chemistry*; D008422:Materials Testing; D015394:Molecular Structure; D010316:Particle Size; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
D000180:Acrylic Resins; D001672:Biocompatible Materials; D004337:Drug Carriers; D005782:Gels; D047392:beta-Cyclodextrins; C052970:poly-N-isopropylacrylamide; C031215:betadex