title: Culture of exoerythrocytic stages of the malaria parasites Plasmodium falciparum and Plasmodium vivax.
abstract: The two most prevalent human malaria parasites, Plasmodium falciparum and Plasmodium vivax, cause the majority of malaria-related morbidity and mortality. Compared with our knowledge about the erythrocytic stages, we understand little about the liver exoerythrocytic (EE) stages of the human malaria parasites. Our recent development of a hepatocyte line from normal human liver tissue is crucial for successful culturing of the liver stages of both P. falciparum and P. vivax. This technical advancement should be an important tool for directly studying developmental biology of the EE stages of the human malaria parasites and developing drugs against parasite liver stages.
authors.affiliation: Department of Entomology, The Pennsylvania State University, University Park, Pennsylvania, USA.
authors.forename: Liwang
authors.initials: L
authors.lastname: Cui
authors.forename: Namtip
authors.initials: N
authors.lastname: Trongnipatt
authors.forename: Jetsumon
authors.initials: J
authors.lastname: Sattabongkot
authors.forename: Rachanee
authors.initials: R
authors.lastname: Udomsangpetch
mesh_terms: D000818:Animals; D002460:Cell Line; D009033:Culicidae / Q000469:parasitology; D004912:Erythrocytes / Q000469:parasitology; D022781:Hepatocytes / Q000469:parasitology; D006790:Host-Parasite Interactions; D006801:Humans; D008099:Liver / Q000469:parasitology; D016778:Malaria, Falciparum / Q000469:parasitology / Q000635:transmission; D016780:Malaria, Vivax / Q000469:parasitology / Q000635:transmission; D052940:Merozoites / Q000254:growth & development; D010963:Plasmodium falciparum / Q000254:growth & development* / Q000472:pathogenicity; D010966:Plasmodium vivax / Q000254:growth & development* / Q000472:pathogenicity; D034101:Sporozoites / Q000254:growth & development