De novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes.
Mouse blastocyst stage embryo stained for histone H3 lysine-27 trimethylation (red) and DNA (blue). H3K27me3 marks the inactive X chromosome. The study by Chiba et al. in this issue suggests that de novo DNA methyltransferases are dispensable for setting the imprint on the maternally-derived X chromsome in growing oocytes. See Chiba et al. in this issue.
Chiba
Hatsune
H
Division of Human Genetics, Department of Integrated Genetics, National Institute of Genetics, Research Organization of Information and Systems, 1111 Yata, Mishima, Japan.
Hirasawa
Ryutaro
R
Kaneda
Masahiro
M
Amakawa
Yuko
Y
Li
En
E
Sado
Takashi
T
Sasaki
Hiroyuki
H
D000818:Animals; D019175:DNA Methylation / Q000235:genetics*; D018392:Genomic Imprinting; D051379:Mice; D009865:Oocytes / Q000502:physiology*; D014960:X Chromosome / Q000235:genetics / Q000378:metabolism*