Downmodulatory effects of the antihistaminic drug bepotastine on cytokine/chemokine production and CD54 expression in human keratinocytes.
Bepotastine besilate is an antihistaminic drug of the second generation with superior clinical responses. In this study, we investigated whether bepotastine modulates the production of cytokines/chemokines and the expression of CD54 in human epidermal keratinocytes. The production of IL-1alpha, CXCL10, and CCL17 and the expression of CD54 were significantly suppressed by the addition of bepotastine. Bepotastine exerts its antiallergic action on keratinocytes by suppressing the production of certain proinflammatory cytokines, both Th1 and Th2 chemokines, and possibly by inhibiting the expression of CD54.
Kobayashi
M
M
Department of Dermatology, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Japan. miw-koba@med.uoeh-u.ac.jp
Kabashima
K
K
Nakamura
M
M
Tokura
Y
Y
D002478:Cells, Cultured; D054414:Chemokine CCL17 / Q000378:metabolism; D054357:Chemokine CXCL10 / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D015536:Down-Regulation; D039563:Histamine H1 Antagonists, Non-Sedating / Q000494:pharmacology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D053582:Interleukin-1alpha / Q000378:metabolism; D015603:Keratinocytes / Q000187:drug effects* / Q000276:immunology; D010880:Piperidines / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*
C106230:CCL17 protein, human; C114753:CXCL10 protein, human; D054414:Chemokine CCL17; D054357:Chemokine CXCL10; D018925:Chemokines; D016207:Cytokines; D039563:Histamine H1 Antagonists, Non-Sedating; C508584:IL1A protein, human; D053582:Interleukin-1alpha; D010880:Piperidines; D011725:Pyridines; D018799:Intercellular Adhesion Molecule-1; C511534:bepotastine besilate