Effect of afobazole on teratogenic activity of cyclophosphamide in rats.
A new anxiolytic afobazole (1-100 mg/kg perorally, Russia) dose-dependently abolished the embryotoxic and teratogenic effects of cyclophosphamide and reduced the range of induced malformations in outbred albino rats. Our results suggest that afobazole possesses antiteratogenic activity.
Shreder
O V
OV
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Smolnikova
N M
NM
Durnev
A D
AD
Seredenin
S B
SB
D000818:Animals; D021461:Animals, Outbred Strains; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001562:Benzimidazoles / Q000494:pharmacology*; D000013:Congenital Abnormalities / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary; D003520:Cyclophosphamide / Q000633:toxicity*; D019610:Cytoprotection / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005328:Fetal Viability / Q000187:drug effects; D009025:Morpholines / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013723:Teratogens / Q000633:toxicity*
C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines; D013723:Teratogens; D003520:Cyclophosphamide