Effect of ototopical ciprofloxacin-dexamethasone on myringotomy in a rat model.
OBJECTIVE
To examine the potential of ototopical ciprofloxacin-dexamethasone (CDX) to delay the closure of myringotomy perforation and to evaluate its effect on inflammation.


METHODS
Prospective, randomized, and controlled.


METHODS
Effusion is obtained in the right middle ear of 24 rats by blocking nasopharyngeal opening of eustachian tube by fibrin glue. Left middle ears of 30 rats remained healthy. Animals were randomly classified into three groups; each containing eight right ears with effusion and 10 rats with healthy left ear. Bilateral myringotomy was applied to all rats and randomly divided into three groups. First group received CDX, second group received serum physiologic (SF) for 14 days. Third group served as control. Otomicroscopy was performed by days 7, 14 and 28 to assess wound healing. On day of 28, all animals were humanly euthanized in order to pathological examination of the tympanic bullas.


RESULTS
CDX group showed lesser perforation closure ratios both in healthy and diseased ears. Inflammation was found to be lesser at CDX group in comparison to other groups.


CONCLUSIONS
Closure of the myringotomy perforation can be modulated by ototopical CDX treatment. This delaying of wound healing may be attributed to antiinflammatory action of dexamethasone.
Yazici
Aylin
A
Haydarpasa Numune Education and Research Hospital Istanbul, Istanbul, Turkey.
Naiboglu
Baris
B
Oysu
Cagatay
C
Toros
Sema Zer
SZ
Noseri
Hulya
H
Karaca
Cigdem Tepe
CT
Egeli
Erol
E
D000287:Administration, Topical; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D008297:Male; D008876:Middle Ear Ventilation; D010034:Otitis Media with Effusion / Q000601:surgery*; D011182:Postoperative Care / Q000379:methods; D011446:Prospective Studies; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014432:Tympanic Membrane / Q000473:pathology / Q000601:surgery; D014945:Wound Healing / Q000187:drug effects
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D002939:Ciprofloxacin; D003907:Dexamethasone