title: Thoracic spine compression fracture during isoniazid-induced seizures: case report.
abstract: We report here an 11-year-old previously healthy girl with isoniazid intoxication who sustained a seizure-induced thoracic compression fracture. The following might be the first such case reported in the medical literature. Isoniazid toxicity should be suspected in any patient who comes to the emergency department with refractory seizures and metabolic acidosis. Forceful muscle contractions during a convulsive seizure can result in vertebral compression fracture, especially in the midthoracic region. A complaint of back pain after isoniazid-induced seizures in patients raises a strong suspicion of vertebral fracture and should be evaluated radiologically.
authors.affiliation: Department of Orthopaedics and Traumatology, Faculty of Medicine, Mustafa Kemal University, Antakya, Hatay, Turkey. orthopedi@gmail.com
authors.forename: Aydner
authors.initials: A
authors.lastname: Kalaci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Duru
authors.forename: Sinem
authors.initials: S
authors.lastname: Karazincir
authors.forename: Teoman Toni
authors.initials: TT
authors.lastname: Sevinç
authors.forename: Güven
authors.initials: G
authors.lastname: Kuvandik
authors.forename: Ali
authors.initials: A
authors.lastname: Balci
mesh_terms: D000931:Antidotes / Q000627:therapeutic use; D001416:Back Pain / Q000209:etiology; D002606:Charcoal / Q000627:therapeutic use; D002648:Child; D062787:Drug Overdose / Q000150:complications / Q000628:therapy; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy; D005260:Female; D050815:Fractures, Compression / Q000000981:diagnostic imaging / Q000209:etiology*; D006801:Humans; D007538:Isoniazid / Q000506:poisoning*; D011736:Pyridoxine / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D011859:Radiography; D013035:Spasm / Q000139:chemically induced / Q000150:complications*; D016103:Spinal Fractures / Q000209:etiology*; D013904:Thoracic Vertebrae / Q000293:injuries*; D005680:gamma-Aminobutyric Acid / Q000172:deficiency
chemical_list: D000931:Antidotes; D002606:Charcoal; D005680:gamma-Aminobutyric Acid; D011736:Pyridoxine; D007538:Isoniazid