[Psychological stress status in patients with acute coronary syndrome and stable angina pectoris].
OBJECTIVE
To observe the psychological stress status in patients with acute coronary syndrome (ACS) and stable angina pectoris (SA).


METHODS
The intensity of social psychological stress and the serum levels of IL-6, CRP and ICAM-1 were determined in patients with ACS (n = 67) and SA (n = 33).


RESULTS
(1) The percentage of patients with psychological stress was significantly higher in ACS than that in SA group (78.8% vs. 21.2%, P < 0.01). (2) The serum levels of CRP [(14.82 +/- 5.07) g/L vs. (8.78 +/- 4.34) g/L], IL-6 [(101.7 +/- 22.2) ng/L vs. (71.1 +/- 23.5) ng/L] and sICAM-1 [(1.41 +/- 0.47) mg/L vs. (0.82 +/- 0.37) mg/L] were significantly higher in psychological stress group than those in non-psychological stress group (all P < 0.05). Serum CRP [(18.91 +/- 3.12) g/L vs. (6.20 +/- 2.46) g/L], IL-6 [(114.6 +/- 15.2) ng/L vs. (56.4 +/- 15.8) ng/L] and sICAM-1 [(1.67 +/- 0.39) mg/L vs. (0.63 +/- 0.28) mg/L] levels in ACS group were significantly higher than those in SA group (all P < 0.01).


CONCLUSIONS
Higher psychological stress was associated with higher risk of ACS and increased serum inflammatory cytokines.
Li
Mu-Wei
MW
Department of Cardiology, Henan Provincial People's Hospital, Zhengzhou 450003, China. limuwei @medmail.com.cn
Yang
Lei
L
Gao
Chuan-Yu
CY
Shen
Yu-Xiang
YX
Ma
Ye-Xin
YX
D054058:Acute Coronary Syndrome / Q000097:blood* / Q000523:psychology*; D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological
D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein