[The role of structural changes of the endothelium and myocardium in the development of experimental heart failure].
The aim of the investigation was to study the role of structural myocardial and endothelial reorganization during the experimental heart failure (doxorubicin model). Rat endocardial and aortal endothelium as well as left ventricular myocardium, were studied using the methods of light and electron microscopy and immunocytochemistry (TUNEL-assay). The major regularities of structural and functional myocardial and endothelial reorganization were determined in rats with an experimental heart failure. The pronounced cardiomyocyte (CMC) heteromorphism was found. CMCs with the signs of hypertrophy and hyperplasia were identified together with the CMCs showing discomplexation of sarcomeres and fragmentation of myofibrils, CMCs with the numerous caveolae, liposomes, autophagosomes and myelin-like bodies. The peculiarities of the ultrastructural changes were established in the endocardial and aortal endothelium. The increase in CMC and endothelial cell number showing the signs of apoptosis, was demonstrated. The role of structural and functional myocardial and endothelial reorganization during experimental heart failure is discussed.
Salikova
S P
SP
Bakhtiiarov
R Z
RZ
D000818:Animals; D004317:Doxorubicin; D004730:Endothelium, Vascular / Q000473:pathology*; D006333:Heart Failure / Q000139:chemically induced / Q000473:pathology*; D006352:Heart Ventricles / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000473:pathology*; D051381:Rats
D004317:Doxorubicin