Cytotoxic macrocyclic diterpenoids from Euphorbia helioscopia.
A new cytotoxic macrocyclic diterpenoid, euphornin L (1), together with seven known analogues were isolated from the plant Euphorbia helioscopia L. The structure of 1 was elucidated by spectral data and X-ray crystallographic analysis. Euphornin L (1) and euphoscopin F (2) exhibited significant cytotoxicity against HL-60 cell lines with IC(50) values of 2.7 and 9.0 microM, respectively. The 13C-NMR data of euphoscopin F (2), epieuphoscopin B (3), euphoscopin B (5), and euphoscopin C (6) were also reported for the first time.
Tao
Hong-Wen
HW
Key Laboratory of Marine Drugs, Ministry of Education, Qingdao, China.
Hao
Xiao-Jiang
XJ
Liu
Pei-Pei
PP
Zhu
Wei-Ming
WM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D028481:Euphorbia / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D010936:Plant Extracts / Q000032:analysis; D028321:Plant Preparations / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet; D014961:X-Ray Diffraction
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D047028:Macrocyclic Compounds; D010936:Plant Extracts; D028321:Plant Preparations