Expression of CD70 and the TH17 transcription factor RORgammaT in human contact dermatitis.
Contact sensitizers are a major cause of inflammatory skin disease and as topical immunomodulators also have the potential for treating cancer, viral diseases and certain autoimmune disorders. In the present study, the authors identify the upregulation of the TH17 lymphocyte subset transcription factor retinoid orphan receptor gamma T (RORgammaT) and the CD70 costimulatory pathway in human contact sensitivity (CS) using molecular techniques. Identification of this important new subset of T lymphocytes and a recognized costimulatory pathway offers potential for ameliorating CS and insight into antitumor and antiviral mechanism of haptens as topical immunomodulators.
Martiniuk
Frank
F
Department of Medicine-Pulmonary Division, New York University School of Medicine, New York, NY 10016, USA.
Lee
David S
DS
Gaspari
Anthony
A
Yee
Herman
H
Chiriboga
Luis
L
Huie
Maryann
M
Tchou-Wong
Kam-Meng
KM
Levis
William R
WR
D053282:CD27 Ligand / Q000096:biosynthesis* / Q000235:genetics*; D003877:Dermatitis, Contact / Q000235:genetics* / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007155:Immunologic Factors / Q000502:physiology; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D018168:Receptors, Retinoic Acid / Q000235:genetics* / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone / Q000235:genetics* / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016176:T-Lymphocyte Subsets / Q000378:metabolism*; D016707:Tissue Fixation
D053282:CD27 Ligand; D007155:Immunologic Factors; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; C539900:RORC protein, human; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone