[Anti-VEGF therapy for peritoneal dissemination model of gastric cancer considering of pharmacokinetics].
Vascular Endothelial Growth Factor (VEGF) plays an important role in proliferation of cancer cells, angiogenesis and vascular permeability in peritoneal dissemination. Now we investigated the efficacy of anti-VEGF therapy in peritoneal dissemination of gastric cancer considering of pharmacokinetics. We investigated pharmacokinetics of bevacizumab, humanized anti-VEGF monoclonal antibody in subcutaneous xenograft and peritoneal dissemination model of OCUM-2MD3, highly peritoneal-seeding cell line of human scirrhous gastric carcinoma. In the group of intraperitoneal administration, bevacizumab remains in the intraperitoneal cavity and transits slowly to blood pool. On the other hand, in the group of subcutaneous administration, bevacizumab transits faster to blood pool and is accumulated in subcutaneous tumors and peritoneal nodules. Bevacizumab administered intraperitoneally seemed to neutralize intraperitoneal VEGF. Bevacizumab administered in subcutaneous seemed to act on peritoneal wall and control vascular permeability. Systemic administration of anti-VEGF agent will be a potential therapy in peritoneal dissemination of gastric cancer.
Yagi
Yasumichi
Y
Dept. of Gastroenterological Surgery, Kanazawa University.
Fushida
Sachio
S
Fujita
Hideto
H
Kinami
Shinichi
S
Ninomiya
Itasu
I
Fujimura
Takashi
T
Kayahara
Masato
M
Ohta
Tetsuo
T
Yashiro
Masakazu
M
Hirakawa
Kousei
K
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D008819:Mice, Nude; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000276:immunology* / Q000556:secondary; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000276:immunology* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology*; D023041:Xenograft Model Antitumor Assays
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab