[Risk factors for fungal pneumonia in neonates: analysis of 160 cases].
OBJECTIVE
To study the risk factors for the development of fungal pneumonia in neonates.


METHODS
A total of 260 neonates with nosocomial infectious pneumonia were classified into two groups: fungal pneumonia (n=160) and bacterial pneumonia (n=100). Their medical data were retrospectively studied.


RESULTS
Eighty-seven percent of patients in the fungal pneumonia group had a duration of hospital stay of >10 days, but 30.1% of patients in the bacterial pneumonia group (p<0.01). The preterm infants in the fungal pneumonia group accounted for 49.5%, which was significantly higher than that in the bacterial pneumonia group (22.0%) (p<0.01). In the fungal pneumonia group, 59.9% of patients showed a weight of <2 500 g, but 34.0% of patients in the bacterial pneumonia group (p<0.01). The duration of the combined use of more than two broad-spectrum antibiotics (p<0.05) and the total duration of antibiotics use in the fungal pneumonia group was significantly longer than that in the bacterial pneumonia group (p<0.05). Nosocomial infectious bacterial pneumonia was common as the primary disease of fungal pneumonia (n=145).


CONCLUSIONS
Premature delivery, lower weight, longer duration of hospital stay and antibiotics use, and combined use of more than two broad-spectrum antibiotics may increase the risk of fungal pneumonia in neonates. The development of fungal pneumonia may be related to nosocomial infectious bacterial pneumonia in neonates.
Yang
Yu-Xia
YX
Department of Pediatrics, Third Hospital Affiliated to Zhengzhou University, Zhengzhou 450052, China. yyx6873@sina.com.cn
Luan
Bin
B
Qiao
Jun-Ying
JY
D000900:Anti-Bacterial Agents / Q000009:adverse effects; D003428:Cross Infection / Q000150:complications; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D009181:Mycoses / Q000209:etiology*; D011014:Pneumonia / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors
D000900:Anti-Bacterial Agents