Affinity of Tomopenem (CS-023) for penicillin-binding proteins in Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa.
Tomopenem (formerly CS-023), a novel 1beta-methylcarbapenem, exhibited high affinity for penicillin-binding protein (PBP) 2 in Staphylococcus aureus, PBP 2 in Escherichia coli, and PBPs 2 and 3 in Pseudomonas aeruginosa, which are considered major lethal targets. Morphologically, tomopenem induced spherical forms in E. coli and short filamentation with bulges in P. aeruginosa, which correlated with the drug's PBP profiles. The potential of resistance of these bacteria to tomopenem was comparable to that to imipenem.
Koga
Tetsufumi
T
Biological Research Laboratories IV, Daiichi Sankyo Co, Ltd, Tokyo, Japan. koga.tetsufumi.zj@daiichisankyo.co.jp
Sugihara
Chika
C
Kakuta
Masayo
M
Masuda
Nobuhisa
N
Namba
Eiko
E
Fukuoka
Takashi
T
D015780:Carbapenems / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D008826:Microbial Sensitivity Tests; D009154:Mutation; D046915:Penicillin-Binding Proteins / Q000378:metabolism* / Q000648:ultrastructure; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D013211:Staphylococcus aureus / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure
D015780:Carbapenems; D046915:Penicillin-Binding Proteins; C492232:tomopenem