title: Effective use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% for analgesia in refractory proctodynia.
abstract: Idiopathic proctodynia, an enigmatic pain syndrome affecting the perianal region, can be persistent, relatively refractory to treatment, and associated with considerable psychological distress. The authors present the case of a patient with a long history of severe proctodynia that had been resistant to a range of topical and systemic treatments. With the use of topical amitriptyline hydrochloride 2.5% and ketamine hydrochloride 0.5% cream, the patient's pain resolved rapidly, leading to a substantially improved quality of life.
authors.affiliation: Department of Dermatology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Julia S
authors.initials: JS
authors.lastname: Lehman
authors.forename: Gabriel F
authors.initials: GF
authors.lastname: Sciallis
mesh_terms: D000287:Administration, Topical; D000639:Amitriptyline / Q000008:administration & dosage*; D001003:Anal Canal / Q000503:physiopathology; D000700:Analgesics / Q000008:administration & dosage*; D004338:Drug Combinations; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D011788:Quality of Life; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D004338:Drug Combinations; D000639:Amitriptyline; D007649:Ketamine