Infections and the antiphospholipid syndrome.
Currently, the origin of autoimmune diseases is considered to be multifactorial. Genetic predisposition, immune system malfunction or even backfire, hormonal regulation, and environmental factors, i.e. infections, all play important roles in the pathogenesis of autoimmune diseases such as the antiphospholipid syndrome (APS). New drugs and strategies aimed at preventing infections could further improve the outcome of APS and other autoimmune diseases.
García-Carrasco
Mario
M
Systemic Autoimmune Diseases Research Unit, CMN Manuel Avila Camacho, IMSS, Puebla, México. mgc30591@yahoo.com
Galarza-Maldonado
Claudio
C
Mendoza-Pinto
Claudia
C
Escarcega
Ricardo O
RO
Cervera
Ricard
R
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D000942:Antigens, Bacterial / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D016736:Antiphospholipid Syndrome / Q000209:etiology* / Q000503:physiopathology; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D004266:DNA Virus Infections / Q000150:complications* / Q000276:immunology; D004267:DNA Viruses / Q000276:immunology* / Q000472:pathogenicity; D050982:GATA1 Transcription Factor / Q000276:immunology; D006094:Gram-Positive Bacteria / Q000276:immunology* / Q000472:pathogenicity; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D018716:Molecular Mimicry
D019268:Antibodies, Antineutrophil Cytoplasmic; D017152:Antibodies, Antiphospholipid; D000942:Antigens, Bacterial; D000956:Antigens, Viral; D001324:Autoantigens; D050982:GATA1 Transcription Factor