title: Leptomeningeal metastasis from ovarian carcinoma successfully treated by the intraventricular administration of methotrexate.
abstract: A 60-year-old woman with a history of ovarian carcinoma and complaining of gait instability, dizziness, nausea, and a right temporal headache visited a neurologist. A diagnosis of leptomeningeal metastasis was made, based on the results of a cerebrospinal fluid examination. After the administration of intrathecal methotrexate, her neurological complaints disappeared. An Ommaya intraventricular reservoir was inserted, and methotrexate administration was continued for 11 months, until another recurrence was found in her pelvis. Although uncommon, the possibility of leptomeningeal metastasis from ovarian carcinoma should be considered; in such cases, treatment with intraventricular methotrexate may be effective and feasible and should be considered as a treatment strategy.
authors.affiliation: National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Goto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Katsumata
authors.forename: Shunichi
authors.initials: S
authors.lastname: Nakai
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sasajima
authors.forename: Kan
authors.initials: K
authors.lastname: Yonemori
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kouno
authors.forename: Chikako
authors.initials: C
authors.lastname: Shimizu
authors.forename: Masashi
authors.initials: M
authors.lastname: Ando
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fujiwara
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D005260:Female; D005682:Gadolinium; D006801:Humans; D007276:Injections, Intraventricular; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008727:Methotrexate / Q000008:administration & dosage*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D005682:Gadolinium; D008727:Methotrexate