title: [Clinical significance of the expression of p53, p63 and p73 in nasal and paranasal sinus carcinoma].
abstract: OBJECTIVE
  To study the clinical significance of the expression of p53, p63 and p73 protein and the correlation of p53 and p63 in nasal and paranasal sinus carcinoma (NPSC).
  
  
  METHODS
  The immunohistochemical technique was used to detect the expression of p53, p63 and p73 in 67 cases of NPSC, para-cancer tissues and non-cancer tissues.
  
  
  RESULTS
  The positive rate of p53 and p63 protein in NPSC was significantly higher than that in park cancer tissues and non-cancer tissues (P<0.01), and there were a positive correlation between the expression of p53 and p63 protein in NPSC (P<0.01). But the expression of p73 had no significant difference among NPSC, para-cancer tissues and non-cancer tissues (P>0.05).
  
  
  CONCLUSIONS
  There are positive correlation between p53 and p63 protein in NPSC, and they may play an important role in the tumorgenesis of NPSC. The p73 may not be associated with tumorgenesis of NPSC.
authors.affiliation: Department of Otolaryngology, the First Affiliated Hospital of Ji'nan University, Guangzhou, 510630, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: Haiying
authors.initials: H
authors.lastname: Jia
authors.forename: Jiqun
authors.initials: J
authors.lastname: Wang
authors.forename: Yanchun
authors.initials: Y
authors.lastname: Shan
authors.forename: Sijin
authors.initials: S
authors.lastname: Luo
authors.forename: Zhi
authors.initials: Z
authors.lastname: Tang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism* / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism*; D010255:Paranasal Sinus Neoplasms / Q000378:metabolism* / Q000469:parasitology; D015534:Trans-Activators / Q000378:metabolism*; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C115051:TP63 protein, human; C000606460:TP73 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins