[Regenerative potentialities of pancreatic tissues in experimental infectious pancreonecrosis].
The repair processes in the pancreas in infected pancreonecrosis after oxytocin (OT) administration were studied in 120 male rats with the body mass of 280-310 g, using light microscopy, histochemistry, electron microscopy and immunocytochemistry (p53 protein detection). Pancreonecrosis was induced by microtraumatizing the pancreatic lobules with bile injection and Staphylococcus aureus suspension infusion. During days 3-14, the intensifying processes of ischemia, acinar and ductal lysis, pancreatocyte dystrophy and death were observed in experimental animals. In paranecrotic areas, acinar discomplexation was found together with the signs of increased secretory activiry in pancreatocytes. Pancreatic tissues were infiltrated with erythrocytes, granulocytes, lymphocytes and macrophages which were actively engaged in phagocytosis. OT was found to create the conditions necessary for adequate realization of the regenerative properties of pancreatocytes, microvessels, cells of fibroblastic line, and macrophages with a concomitant decrease of apoptotic dominant in cellular elements.
Sheina
E A
EA
Stadnikov
B A
BA
Tret'iakov
A A
AA
D000818:Animals; D006651:Histocytochemistry; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology; D008264:Macrophages / Q000276:immunology / Q000502:physiology; D008297:Male; D009336:Necrosis; D010121:Oxytocin / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism / Q000382:microbiology / Q000473:pathology*; D010195:Pancreatitis / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D012038:Regeneration / Q000502:physiology*; D013211:Staphylococcus aureus; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D016159:Tumor Suppressor Protein p53; D010121:Oxytocin