title: Formylnitroenamines: useful building blocks for nitrated pyridones and aminopyridines with functional groups.
abstract: beta-formyl-beta-nitroenamines possess both an electrophilic formyl group and a nucleophilic amino group and, therefore, serve as C3N1 building blocks having a nitro group to afford nitropyridones and aminonitropyridines with a functional group at the 3-position. Upon treatment with malonic acid derivatives or beta-keto esters, nitropyridones were obtained, whereas reactions with functionalized acetonitriles afford aminonitropyridines, via a formal transfer of an alkyl group from the ring nitrogen to the imino group. These procedures provide practical and useful methods for preparation of heterocycles with a nitro group.
authors.affiliation: Division of Frontier Materials Science, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
authors.forename: Yumi
authors.initials: Y
authors.lastname: Nakaike
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hayashi
authors.forename: Nagatoshi
authors.initials: N
authors.lastname: Nishiwaki
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Tobe
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ariga