title: Coronary heart disease is associated with non-amnestic mild cognitive impairment.
abstract: The progression of amnestic mild cognitive impairment (a-MCI) to Alzheimer's disease and hypothesized progression of non-amnestic mild cognitive impairment (na-MCI) to non-degenerative or vascular dementias suggest etiologic differences. We examined the association between coronary heart disease (CHD) and mild cognitive impairment (MCI) subtypes in a population-based cohort. Participants (n=1969; aged 70-89 years) were evaluated using the Clinical Dementia Rating Scale, a neurological examination, and neuropsychological testing for diagnoses of normal cognition, MCI, or dementia. CHD was defined as a history of myocardial infarction, angina, angiographic coronary stenosis, or coronary revascularization and ascertained by participant interview and from medical records. CHD was significantly associated with na-MCI (OR=1.93; 95% CI=1.22-3.06) but not with a-MCI (OR=0.94; 95% CI=0.69-1.28). In contrast, ApoE ɛ4 allele was significantly associated with a-MCI (OR=1.75; 95% CI=1.28-2.41), but not with na-MCI (OR=1.17; 95% CI=0.69-2.00). The association of CHD with prevalent na-MCI but not with a-MCI suggests that CHD and na-MCI may have similar underlying etiologies.
authors.affiliation: Mayo Clinic, Department of Health Sciences Research, Division of Epidemiology, 200 First Street SW, Rochester, MN 55905, United States. roberts.rosebud@mayo.edu
authors.forename: Rosebud O
authors.initials: RO
authors.lastname: Roberts
authors.forename: David S
authors.initials: DS
authors.lastname: Knopman
authors.forename: Yonas E
authors.initials: YE
authors.lastname: Geda
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Cha
authors.forename: Véronique L
authors.initials: VL
authors.lastname: Roger
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000453:epidemiology* / Q000378:metabolism; D053327:Apolipoprotein E4 / Q000378:metabolism*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000453:epidemiology* / Q000378:metabolism; D015331:Cohort Studies; D015897:Comorbidity; D003327:Coronary Disease / Q000453:epidemiology* / Q000378:metabolism; D003430:Cross-Sectional Studies; D003704:Dementia / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008910:Minnesota / Q000453:epidemiology; D012016:Reference Values
chemical_list: D053327:Apolipoprotein E4