title: Gastric and duodenal antiulcer activity of alkaloids: a review.
abstract: Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals.
authors.affiliation: Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, Brazil. heloinafalcao@yahoo.com.br
authors.forename: Heloina
authors.initials: H
authors.lastname: de Sousa Falcão
authors.forename: Jacqueline Alves
authors.initials: JA
authors.lastname: Leite
authors.forename: José Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.forename: Petrônio Filgueiras
authors.initials: PF
authors.lastname: de Athayde-Filho
authors.forename: Maria Célia
authors.initials: MC
authors.lastname: de Oliveira Chaves
authors.forename: Marcelo Dantas
authors.initials: MD
authors.lastname: Moura
authors.forename: Anderson Luiz
authors.initials: AL
authors.lastname: Ferreira
authors.forename: Ana Beatriz Albino
authors.initials: AB
authors.lastname: de Almeida
authors.forename: Alba Regina Monteiro
authors.initials: AR
authors.lastname: Souza-Brito
authors.forename: Margareth
authors.initials: M
authors.lastname: de Fátima Formiga Melo Diniz
authors.forename: Leônia Maria
authors.initials: LM
authors.lastname: Batista
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D023421:Models, Animal; D013276:Stomach Ulcer / Q000188:drug therapy*
chemical_list: D000470:Alkaloids; D000897:Anti-Ulcer Agents