title: Hydroxyapatite coating by sol-gel on Ti-6Al-4V alloy as drug carrier.
abstract: In this study Ti-6Al-4V samples were used as substrates and Ca-P layers were deposited using sol-gel technique and covered by spin-coating. The efficiency of hydroxyapatite (HA) coatings as drug carrier was also evaluated by immersion in gentamicin sulphate solution and the release profiles were obtained by cumulative method of the coating samples. Three non-linear mathematical methods were employed in order to discuss a possible mechanism to lead the drug release. Physical chemical techniques showed the presence of the typical absorption bands of calcium phosphates by infrared spectroscopy while X-ray diffraction peaks matched up with hydroxyapatite patterns. Microstructural techniques (SEM, EDS) help to confirm the hydroxyapatite coating by surface aspect and Ca/P ratio (1.64). The best fitting according statistical results explained each stage of the released profiles and correspond to a mixture of short initial burst effect plus drug dissolution with a specific kinetic and the diffusion of the gentamicin solid particles.
authors.affiliation: Department of Ceramic and Composites, Centro de Biomateriales, Universidad de La Habana, Havana, Cuba.
authors.forename: Eduardo Peón
authors.initials: EP
authors.lastname: Avés
authors.forename: Gaston Fuentes
authors.initials: GF
authors.lastname: Estévez
authors.forename: Marcia Soares
authors.initials: MS
authors.lastname: Sader
authors.forename: Juan C Galván
authors.initials: JC
authors.lastname: Sierra
authors.forename: Julio C Llópiz
authors.initials: JC
authors.lastname: Yurell
authors.forename: Ivan N
authors.initials: IN
authors.lastname: Bastos
authors.forename: Gloria D Almeida
authors.initials: GD
authors.lastname: Soares
mesh_terms: D000497:Alloys; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry*; D006882:Hydroxyapatites / Q000737:chemistry*; D008422:Materials Testing; D044367:Phase Transition; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D000900:Anti-Bacterial Agents; D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D005839:Gentamicins; D006882:Hydroxyapatites; C031462:titanium alloy (TiAl6V4); D014025:Titanium