title: Dynamics of specific vesicle-substrate adhesion: from local events to global dynamics.
abstract: We present a synergistic combination of simulations and experimental data on the dynamics of membrane adhesion. We show that a change in either the density or the strength of the bonds results in very different dynamics. Such behavior is explained by introducing an effective binding affinity that emerges as a result of the competition between the strength of the chemical bonds and the environment defined by the fluctuating membrane.
authors.affiliation: II. Institut für Theoretische Physik, Universität Stuttgart, D-70550 Stuttgart, Germany.
authors.forename: Ellen
authors.initials: E
authors.lastname: Reister-Gottfried
authors.forename: Kheya
authors.initials: K
authors.lastname: Sengupta
authors.forename: Barbara
authors.initials: B
authors.lastname: Lorz
authors.forename: Erich
authors.initials: E
authors.lastname: Sackmann
authors.forename: Udo
authors.initials: U
authors.lastname: Seifert
authors.forename: Ana-Suncana
authors.initials: AS
authors.lastname: Smith
mesh_terms: D002448:Cell Adhesion / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D003198:Computer Simulation; D007700:Kinetics; D008954:Models, Biological