title: Transgastric ventral hernia repair: a controlled study in a live porcine model (with videos).
abstract: BACKGROUND
  Ventral hernia repair is currently performed via open surgery or laparoscopic approach.
  
  
  OBJECTIVE
  To develop an alternative ventral hernia repair technique.
  
  
  METHODS
  Acute and survival experiments on twelve 50-kg pigs.
  
  
  METHODS
  An endoscope was introduced transgastrically into the peritoneal cavity. An abdominal wall hernia was created through a 5-mm skin incision followed by a 5-cm-long incision of the abdominal wall muscles and aponeurosis. A hernia repair technique was developed in 3 acute experiments. Then animals were randomized into 2 groups. In the experimental group (5 animals) Gore-Tex mesh was transgastrically attached to the abdominal wall, repairing the previously created abdominal wall hernia. In the control group (4 animals), the hernia was not repaired. In both groups, the endoscope was then withdrawn into the stomach, and the gastric wall incision was closed with T-bars. The animals survived for 2 weeks and were then euthanized.
  
  
  METHODS
  The presence of ventral hernia on necropsy.
  
  
  RESULTS
  In the control group, the ventral hernia was present on necropsy in all animals. In the experimental group, the ventral hernia was easily repaired, with no evidence of hernia on necropsy. In the first animal in the experimental group, necropsy revealed infected mesh. After this discovery, we used sterilized cover for mesh delivery and did not find any signs of infection in 4 subsequent study animals.
  
  
  CONCLUSIONS
  The study was performed in a porcine model.
  
  
  CONCLUSIONS
  Transgastric ventral hernia repair is feasible, technically easy, and effective. It can become a less invasive alternative to the currently used laparoscopic and surgical ventral hernia repair.
authors.affiliation: Institute for Digestive Health and Liver Disease at Mercy Medical Center, Baltimore, Maryland 21202 , USA. skan51@hotmail.com
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Kantsevoy
authors.forename: Xavier
authors.initials: X
authors.lastname: Dray
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Shin
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Buscaglia
authors.forename: Priscilla
authors.initials: P
authors.lastname: Magno
authors.forename: Lia
authors.initials: L
authors.lastname: Assumpcao
authors.forename: Michael R
authors.initials: MR
authors.lastname: Marohn
authors.forename: Jay
authors.initials: J
authors.lastname: Redan
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Giday
authors.forename: Michael A
authors.initials: MA
authors.lastname: Schweitzer
mesh_terms: D000818:Animals; D016001:Confidence Intervals; D004195:Disease Models, Animal; D004724:Endoscopy / Q000379:methods*; D005260:Female; D020699:Gastroscopes; D046449:Hernia, Abdominal / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007813:Laparotomy / Q000379:methods; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D011138:Polytetrafluoroethylene / Q000627:therapeutic use*; D011336:Probability; D011897:Random Allocation; D012680:Sensitivity and Specificity; D013526:Surgical Mesh; D015996:Survival Rate; D013552:Swine; D013718:Tensile Strength; D020535:Video-Assisted Surgery / Q000379:methods
chemical_list: D011138:Polytetrafluoroethylene