Human infection with highly pathogenic avian influenza virus (H5N1) in northern Vietnam, 2004-2005.
We performed a retrospective case-series study of patients with influenza A (H5N1) admitted to the National Institute of Infectious and Tropical Diseases in Hanoi, Vietnam, from January 2004 through July 2005 with symptoms of acute respiratory tract infection, a history of high-risk exposure or chest radiographic findings such as pneumonia, and positive findings for A/H5 viral RNA by reverse transcription-PCR. We investigated data from 29 patients (mean age 35.1 years) of whom 7 (24.1%) had died. Mortality rates were 20% (5/25) and 50% (2/4) among patients treated with or without oseltamivir (p = 0.24), respectively, and were 33.3% (5/15) and 14.2% (2/14) among patients treated with and without methylprednisolone (p = 0.39), respectively. After exact logistic regression analysis was adjusted for variation in severity, no significant effectiveness for survival was observed among patients treated with oseltamivir or methylprednisolone.
Hien
Nguyen Duc
ND
National Institute of Infectious and Tropical Diseases, Hanoi, Vietnam.
Ha
Nguyen Hong
NH
Van
Nguyen Tuong
NT
Ha
Nguyen Thi Minh
NT
Lien
Trinh Thi Minh
TT
Thai
Nguyen Quoc
NQ
Trang
Van Dinh
VD
Shimbo
Takuro
T
Takahashi
Yoshimitsu
Y
Kato
Yasuyuki
Y
Kawana
Akihiko
A
Akita
Samu
S
Kudo
Koichiro
K
D000293:Adolescent; D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000635:transmission / Q000821:virology; D007251:Influenza, Human / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use; D011200:Poultry / Q000821:virology; D015996:Survival Rate; D016896:Treatment Outcome; D014744:Vietnam / Q000453:epidemiology; D055815:Young Adult
D000998:Antiviral Agents; D005938:Glucocorticoids; D053139:Oseltamivir; D008775:Methylprednisolone