title: Serial follow-up study on renal handling of calcium and phosphorus after soil replacement in Cd-polluted rice paddies estimated using a general linear mixed model.
abstract: A 10-year follow-up study was conducted to investigate the effects of renal handling of calcium (Ca) and phosphorus (P) after the removal of cadmium-polluted soil in rice paddies and replacing it with nonpolluted soil. Using a general linear mixed model, serial changes of Ca and P concentrations in urine and serum (Ca-U/S, P-U/S), fractional excretion of Ca (FECa), and percent tubular reabsorption of P (%TRP) were determined in 37 persons requiring observation in the Cd-polluted Kakehashi River Basin, Japan. Ca-U and Ca-S remained within the normal range in both sexes. FECa in men returned to the normal level within 3.3 years from the completion of soil replacement. Overall, it is suggested that the renal handling of Ca showed no or only a slight change throughout the observation period in both sexes. P-U decreased gradually. P-S showed lower than normal values in the men and values at the lower end of the normal range in women, although the values recovered gradually to normal. %TRP values remained low throughout the observation period and the values did not recover in either sex. However, the results of P-U and P-S suggested that the renal handling of P may recover after the completion of soil replacement.
authors.affiliation: Department of Occupational and Environmental Medicine (A2), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuohku, Chiba, Japan. ekoba@faculty.chiba-u.jp
authors.forename: Etsuko
authors.initials: E
authors.lastname: Kobayashi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suwazono
authors.forename: Ryumon
authors.initials: R
authors.lastname: Honda
authors.forename: Mire
authors.initials: M
authors.lastname: Dochi
authors.forename: Muneko
authors.initials: M
authors.lastname: Nishijo
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Kido
authors.forename: Hideaki
authors.initials: H
authors.lastname: Nakagawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002104:Cadmium / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan; D007668:Kidney / Q000378:metabolism*; D007677:Kidney Function Tests; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D012275:Oryza / Q000378:metabolism*; D010758:Phosphorus / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012987:Soil / Q000032:analysis*; D012989:Soil Pollutants / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D012987:Soil; D012989:Soil Pollutants; D002104:Cadmium; D010758:Phosphorus; D002118:Calcium