title: Immunovirological and therapeutic follow-up of HIV-1/HIV-2-dually seropositive patients.
abstract: Among the 3700 HIV-infected patients followed in our institution, 17 with regular clinical, immunological and virological follow-up and identified as being dually seropositive for HIV-1 and HIV-2 were included in this study. Antiretroviral therapy seemed to be as effective, in terms of virological and immunological response, as in patients infected by HIV-1 alone. Nevertheless, the observed selection of HIV-2 protease resistance mutations in two cases underlines the importance of selecting drugs that are active on both viruses.
authors.affiliation: Groupe hospitalier Bichat-Claude Bernard, Service de Maladies Infectieuses et Tropicales, Paris, France.
authors.forename: Roland
authors.initials: R
authors.lastname: Landman
authors.forename: Florence
authors.initials: F
authors.lastname: Damond
authors.forename: Juliette
authors.initials: J
authors.lastname: Gerbe
authors.forename: Francoise
authors.initials: F
authors.lastname: Brun-Vezinet
authors.forename: Patrick
authors.initials: P
authors.lastname: Yeni
authors.forename: Sophie
authors.initials: S
authors.lastname: Matheron
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects / Q000302:isolation & purification*; D015498:HIV-2 / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents