Expression of transforming growth factor beta1 in ameloblastomas.
The aim of the present study was to compare the expression of transforming growth factor (TGF) beta1 in ameloblastomas (AMs) with different risk of recurrence by immunohistochemistry. A total of 29 cases of AMs were evaluated. The tumors were divided into 2 groups: group A (10 cases) composed of unicystic and peripheral AMs, associated with a low risk of recurrence, and group B (19 cases) composed of solid AMs, associated with a high risk of recurrence. Statistical evaluation showed significant differences between groups A and B lesions, with higher values of positivity for TGF-beta1 in stromal cells in group B tumors (P = 0.0308). No statistically significant differences of immunoreactivity were found in vessels and odontogenic epithelium between the 2 groups. The increased TGF-beta1 expression in tumors with a high risk of recurrence could be explained with the fact that although TGF-beta acts as a potent tumor suppressor in the early stages of tumor progression, later it seems to enhance the invasive phenotype of the tumor.
Iezzi
Giovanna
G
Dental School, University of Chieti-Pescara, Italy.
Piattelli
Adriano
A
Rubini
Corrado
C
Artese
Luciano
L
Goteri
Gaia
G
Perrotti
Vittoria
V
Carinci
Francesco
F
D000564:Ameloblastoma / Q000145:classification / Q000473:pathology*; D001808:Blood Vessels / Q000473:pathology; D003593:Cytoplasm / Q000648:ultrastructure; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D017154:Stromal Cells / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000032:analysis*
D053773:Transforming Growth Factor beta1