title: Postoperative strontium-90 brachytherapy in the prevention of keloids: results and prognostic factors.
abstract: OBJECTIVE
  The aim of this study was to evaluate the results of keloidectomy and strontium 90 brachytherapy in the prevention of keloid recurrence following excision and to identify outcome and the prognostic factors that predict keloid recurrence after irradiation.
  
  
  METHODS
  Data of 612 patients with 892 keloids treated between 1992 and 2006 were evaluated retrospectively. Brachytherapy was performed using a Sr-90Y surface applicator. Total dose was 20 Gy in 10 fractions.
  
  
  RESULTS
  With a median follow-up of 61 months, the overall recurrence-free response rate for all keloids was 87.6%. Multivariate analysis revealed the following prognostic factors for recurrence: keloid size > 5 cm (p < 0.0001), burn scars as the keloid etiology (p < 0.0001), and previous treatment (p < 0.0001). Outcome was not found to be significantly related to the interval between surgery and radiotherapy, sex, or age. Pruritus and skin reddening were the most common symptoms of keloids, but all signs and symptoms abated with time after treatment. Cosmetic results from the keloid treatment were considered good or excellent in 70.6% of the patients.
  
  
  CONCLUSIONS
  Our study findings show that excision plus Sr-90 brachytherapy is effective in the eradication of keloids. Sr-90 radiotherapy (20 Gy in 10 fractions) achieved a similar local control rate, as have higher doses per fraction in other series. It also resulted in a good cosmetic rate and relief of symptoms. Our data further suggest that the initiation of postoperative irradiation within hours of surgical excision is not important to therapeutic outcome.
authors.affiliation: Department of Radiation Oncology, Marilia Medicine School, São Paulo, Brazil. gusviani@gmail.com
authors.forename: Gustavo A
authors.initials: GA
authors.lastname: Viani
authors.forename: Eduardo J
authors.initials: EJ
authors.lastname: Stefano
authors.forename: Sergio L
authors.initials: SL
authors.lastname: Afonso
authors.forename: Ligia I
authors.initials: LI
authors.lastname: De Fendi
mesh_terms: D000293:Adolescent; D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006801:Humans; D007627:Keloid / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012008:Recurrence; D012044:Regression Analysis; D013326:Strontium Radioisotopes / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D013326:Strontium Radioisotopes