RNA under attack: cellular handling of RNA damage.
Damage to RNA from ultraviolet light, oxidation, chlorination, nitration, and akylation can include chemical modifications to nucleobases as well as RNA-RNA and RNA-protein crosslinking. In vitro studies have described a range of possible damage products, some of which are supported as physiologically relevant by in vivo observations in normal growth, stress conditions, or disease states. Damage to both messenger RNA and noncoding RNA may have functional consequences, and work has begun to elucidate the role of RNA turnover pathways and specific damage recognition pathways in clearing cells of these damaged RNAs.
Wurtmann
Elisabeth J
EJ
Department of Cell Biology, Yale University, New Haven, CT 06510, USA. elisabeth.wurtmann@yale.edu
Wolin
Sandra L
SL
D000478:Alkylation; D000818:Animals; D006801:Humans; D053858:Metabolic Networks and Pathways; D018384:Oxidative Stress; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects*; D014466:Ultraviolet Rays
D011506:Proteins; D012313:RNA