title: Polyamine as a signaling molecule for controlling an adaptive mutation.
abstract: In the absence of exogenous polyamines, the polyamine-deficient Escherichia coli mutant shows not only a characteristic dual-phase growth with abnormal growth, growth arrest, and normal growth after mutation, but also a higher expression of the SOS genes than the polyamine-proficient wild type. The interval of the growth arrest is inversely regulated in a polyamine concentration-dependent manner. These results indicate that the polyamines can act as a signal not only for provoking an adaptive mutation, but also for hastening generation of an adaptive mutation.
authors.affiliation: Department of Radiation Biology, Environmental Radiation Research Center, Korean Atomic Energy Research Institute, Yusong, Daejeon, 305-600, Korea.
authors.forename: Il Lae
authors.initials: IL
authors.lastname: Jung
authors.forename: In Gyu
authors.initials: IG
authors.lastname: Kim
mesh_terms: D004926:Escherichia coli / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D011073:Polyamines / Q000378:metabolism*; D013014:SOS Response, Genetics; D015398:Signal Transduction
chemical_list: D029968:Escherichia coli Proteins; D011073:Polyamines