[The role of chemokines CCL3/ MIP-1 alfa and CCL4/ MIP-1 beta in pathogenesis of dry eye syndrome].
OBJECTIVE
To evaluate the concentration of chemokines CCL3/ MIP-1 alfa and CCL4/ MIP-1 beta in film tears in patients with dry eye syndrome.


METHODS
Tears samples were collected from 62 patients with dry eye syndrome and 18 patients from control group. The concentration of chemokines in film tears were determined by immunoenzymatic assay ELISA.


RESULTS
We found statistically increased levels of chemokines CCL3/ MIP-1 alfa and CCL4/ MIP-1 beta in film tears of patients with dry eye syndrom compared with control group.


CONCLUSIONS
Inflammation may play role in pathogenesis of dry eye syndrome.
Malesiński
Roman
R
Z Oddziału Chorób Oczu Wojewódzkiego Szpitala Zespolonego, Białymstoku.
Bakunowicz-Łazarczyk
Alina
A
Wysocka
Jolanta
J
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D054405:Chemokine CCL3 / Q000032:analysis*; D054407:Chemokine CCL4 / Q000032:analysis*; D015352:Dry Eye Syndromes / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013666:Tears / Q000276:immunology*
D054405:Chemokine CCL3; D054407:Chemokine CCL4; D007155:Immunologic Factors