Building blocks for the synthesis of post-translationally modified glycated peptides and proteins.
Growing interest in synthetic peptides carrying post-traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of N(alpha)-Fmoc-Lys-OH derivatives containing N(epsilon)-1-deoxyfructopyranosyl moiety.
Carganico
Stefano
S
Laboratory of Peptide and Protein Chemistry and Biology, Polo Scientifico e Tecnologico, University of Firenze, Sesto Fiorentino I-50019, Italy.
Rovero
Paolo
P
Halperin
Jose A
JA
Papini
Anna Maria
AM
Chorev
Michael
M
D005449:Fluorenes / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000138:chemical synthesis / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry
D005449:Fluorenes; D010455:Peptides; D011134:Polysaccharides; D011506:Proteins; D011714:Pyrans