title: Work-related asthma in Montreal, Quebec: population attributable risk in a community-based study.
abstract: BACKGROUND
  Occupational exposures are an important cause of adult-onset asthma but the population attributable risk percentage (PAR%) has been less frequently studied.
  
  
  OBJECTIVE
  To examine the distribution and determinants of adult asthma in six centres across Canada using data gathered in a community-based study.
  
  
  METHODS
  Data were gathered in a community survey of 2959 adults using the European Community Respiratory Health Survey Protocol. A subsample of 498 subjects completed detailed health and occupational questionnaires, methacholine challenge tests and allergy skin tests. Asthma was defined in three ways: current wheeze, asthma symptoms and/or medication, and airway hyperresponsiveness. Occupational exposures were classified as sensitizers or irritants. Associations between asthma and occupational exposures were examined using logistic regression analysis. Model selection was based on the findings for current wheeze, and the same model was applied to the other definitions of asthma.
  
  
  RESULTS
  Fifty-six per cent of subjects reported ever having had occupational exposure to sensitizers, and 9.8% to irritants. Current wheeze was associated with exposure to irritants (PAR% 4.54%), and airway hyperresponsiveness was associated with exposure to sensitizers (PAR% 30.7%). Neither a history of childhood asthma, atopy, nor confining the analysis to adult-onset asthma affected these associations. Analysis of effect modification suggested two types of work-related asthma: one due to exposure to occupational sensitizers, and the other due to exposure to irritants.
  
  
  CONCLUSIONS
  Detailed assessment of past and current exposures is essential in the investigation of work-related asthma. Childhood asthma reactivated or aggravated by work exposures is not easy to distinguish from asthma induced by work, a misclassification that could lead to an underestimation of work-induced asthma. This should be taken into account in jurisdictions in which persons with work-aggravated asthma are not eligible for workers' compensation.
authors.affiliation: Hacettepe University, Sihhiye Ankara, Turkey. ademir68@gmail.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demir
authors.forename: Lawrence
authors.initials: L
authors.lastname: Joseph
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Becklake
mesh_terms: D000328:Adult; D001985:Bronchial Provocation Tests; D015987:Effect Modifier, Epidemiologic; D005260:Female; D015989:Healthy Worker Effect; D006801:Humans; D016015:Logistic Models; D008297:Male; D009784:Occupational Diseases / Q000453:epidemiology*; D016273:Occupational Exposure; D015995:Prevalence; D011792:Quebec / Q000453:epidemiology; D018570:Risk Assessment; D012907:Smoking / Q000453:epidemiology; D055815:Young Adult