[A case of advanced gastric cancer treated with chemo-radiotherapy as the fourth-line therapy].
A 69-year-old female patient with type 2 advanced gastric cancer (s-T4N0M0H0Cy0P0, f-Stage IIIA) located from lower corps to antrum underwent a distal gastrectomy with D2 lymphandectomy in May 2006. After surgical treatment, S-1+ docetaxel combined chemotherapy was started for pEM (+) due to direct invasion to pancreas head as the first-line chemotherapy. However, the local recurrence whose diameter was 24 mm at pancreas head was detected with enhanced CT in December 2006. Moreover, nevertheless CPT-11+CDDP combined chemotherapy or paclitaxel monotherapy as the second or the third-line chemotherapy, respectively, the diameter of the local recurrence enlarged to 38 mm in November 2007. Therefore, chemo-radiotherapy using with S-1 and CDDP was started in December 2007 and the diameter of local recurrence was reduced to 25 mm in January 2008. No adverse event of grade 3 or more occurred during chemo-radiotherapy except for grade 3 of neutropenia. Chemo-radiotherapy for this gastric-cancer patient with local recurrence of multiple anti-tumor drug resistance was effective and safe.
Imamura
Hiroshi
H
Dept. of Surgery, Sakai Municipal Hospital.
Furukawa
Hiroshi
H
Kishimoto
Tomono
T
Miyazaki
Yasuhiro
Y
Ohta
Katsuya
K
Yamamoto
Tameyoshi
T
Takemoto
Hiroyoshi
H
Fukunaga
Mutsumi
M
Ohsato
Hiroki
H
Tatsuta
Masayuki
M
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005743:Gastrectomy; D005773:Gastroscopy; D006801:Humans; D009367:Neoplasm Staging; D016879:Salvage Therapy; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents