Evidence that thienamycin biosynthesis proceeds via C-5 epimerization: ThnE catalyzes the formation of (2S,5S)-trans-carboxymethylproline.
Hamed
Refaat B
RB
Department of Chemistry, Oxford University, UK.
Batchelar
Edward T
ET
Mecinović
Jasmin
J
Claridge
Timothy D W
TD
Schofield
Christopher J
CJ
D000595:Amino Acid Sequence; D004926:Escherichia coli / Q000235:genetics; D008025:Ligases / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D011392:Proline / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D013237:Stereoisomerism; D013302:Streptomyces / Q000201:enzymology*; D013845:Thienamycins / Q000096:biosynthesis* / Q000737:chemistry*
C538864:(2S,5S)-trans-carboxymethylproline; D013845:Thienamycins; D011392:Proline; D008025:Ligases; C015537:thienamycin