Design and demonstration of a small-animal up-conversion imager.
This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles.
Salthouse
Christopher
C
Center for Molecular Imaging Research, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA. mahmood@helix.mgh.harvard.edu
Hildebrand
Scott
S
Weissleder
Ralph
R
Mahmood
Umar
U
D000818:Animals; D003952:Diagnostic Imaging / Q000295:instrumentation* / Q000379:methods*; D004583:Electrons; D004867:Equipment Design; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted; D008099:Liver / Q000473:pathology*; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry; D036103:Nanotechnology / Q000379:methods; D017785:Photons