[Treatment of chronic osteomyelitis with antibiotic-loaded calcium phosphate cement].
The antibiotic delayed release system which has the characteristics of high local antibiotic concentration,few adverse effects, slow release and long duration, has became one of important methods of treating chronic osteomyelitis. Because of its double action as drug carrier and bone repair material which can induce bone growth and degrade synchronously, drug impregnated calcium phosphate cement (diCPC) is an ideal and safe antibiotic slow release carrier. After clearing focus thoroughly, defect implant with diCPC is an effective method, which has the virtues of convenient operation, good effects and short staying time etc. This paper aims to summarize the biological properties, experimental study and clinical application of diCPC.
Chen
Hong-Wei
HW
Department of Orthopedics,Yiwu Central Hospital, Yiwu 322000, Zhejiang, China.
Huang
Hong-Bin
HB
Zhao
Gang-Sheng
GS
Ji
Xiang-Rong
XR
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements; D002130:Calcium Phosphates / Q000008:administration & dosage*; D002908:Chronic Disease; D006801:Humans; D010019:Osteomyelitis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D002130:Calcium Phosphates; C020243:calcium phosphate