Supramolecular gel formation and self-correction induced by aggregation-driven conformational changes.
The formation of self-assembled fibrillar networks by low molecular weight peptidomimetics containing a Pro-Val moiety is reported; insight into the aggregation mechanism is provided revealing that it is associated to an unfolding process and that a fibrillar network formed under kinetic control can self-correct into a thermodynamically stable one.
Rodríguez-Llansola
Francisco
F
Universitat Jaume I, Dpt. Química Inorgànica i Orgànica, 12071, Castelló, Spain.
Miravet
Juan F
JF
Escuder
Beatriu
B
D040761:Biomimetic Materials / Q000737:chemistry*; D002942:Circular Dichroism; D005782:Gels / Q000138:chemical synthesis* / Q000737:chemistry*; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry*; D011392:Proline / Q000737:chemistry; D017510:Protein Folding; D013816:Thermodynamics; D014633:Valine / Q000737:chemistry
D005782:Gels; D010455:Peptides; D011392:Proline; D014633:Valine