Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate): a potential new therapy.
Endometriosis is a common and debilitating condition of women in their reproductive age that is associated with pain and infertility. Current medical treatments are only partially effective and associated with wide-ranging side effects. New understanding of local estrogen production by endometriotic tissue and the availability of powerful suppressing drugs may herald a new era in the treatment of this condition.
Fusi
L
L
Institute of Reproductive and Developmental Biology, Imperial College London, Hammersmith Hospital, London, UK. l.fusi@imperial.ac.uk
Purohit
A
A
Brosens
J
J
Woo
L W L
LW
Potter
B V L
BV
Reed
M J
MJ
D000328:Adult; D003374:Coumarins / Q000008:administration & dosage / Q000494:pharmacology*; D018450:Disease Progression; D004715:Endometriosis / Q000188:drug therapy*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D010053:Ovary / Q000378:metabolism; D043266:Steryl-Sulfatase / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D013449:Sulfonamides / Q000008:administration & dosage / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome
D003374:Coumarins; D004791:Enzyme Inhibitors; D004967:Estrogens; D013449:Sulfonamides; D013451:Sulfonic Acids; C520511:irosustat; D043266:Steryl-Sulfatase