[Protective effect of velvet antler polypeptide (VAP) on rats with the spinal cord injury].
OBJECTIVE
To investigate the protective effect of antler polypeptide on the rats with spinal cord injury (SCI).


METHODS
The model rats were treated with different doses of antler polypeptide, and its effect on motor function, ethology and pathological changes of spinal cord of the rats observed.


RESULTS
Seven days after treatment with different doses of antler polypeptide, rat's motor activity was recovered in some extent. Significant difference (P < 0.001)was found between the antler polypeptide treatment group and operation group. The effect could be enhanced by increase of the doses. We observerd the effect on the pathological change of spinal cord in rat, and found the tissue edema and inflammatory infiltration were relieved after treatment with different doses of antler polypeptide, especially in the dose of 15 mg antler polypeptide.


CONCLUSIONS
Antler polypeptide can promote the motor function recovery in SCI rats, and its action is dose-dependent.
Li
Zhen-hua
ZH
Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China. changcnuvlzh@163.com
Leng
Xiang-yang
XY
Gao
Zhong-li
ZL
D000818:Animals; D000999:Antlers / Q000737:chemistry*; D008297:Male; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology
D010455:Peptides