title: Failure of cloxacillin in treatment of a patient with borderline oxacillin-resistant Staphylococcus aureus endocarditis.
abstract: Clinical evidence for failure with beta-lactam therapy has been lacking for patients with borderline oxacillin-resistant Staphylococcus aureus (BORSA) infections. We describe a failure of cloxacillin for a patient with endocarditis due to BORSA. The isolate also had false-negative thermonuclease and coagulase test results.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, University of Saskatchewan, Saskatoon S7N 0W8, Saskatchewan, Canada. stuart.skinner@saskatoonhealthregion.ca
authors.forename: Stuart
authors.initials: S
authors.lastname: Skinner
authors.forename: Melanie
authors.initials: M
authors.lastname: Murray
authors.forename: Tom
authors.initials: T
authors.lastname: Walus
authors.forename: James A
authors.initials: JA
authors.lastname: Karlowsky
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003023:Cloxacillin / Q000627:therapeutic use*; D003030:Coagulase / Q000032:analysis; D024881:Drug Resistance, Bacterial; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008836:Micrococcal Nuclease / Q000032:analysis; D010068:Oxacillin / Q000494:pharmacology*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D003030:Coagulase; D008836:Micrococcal Nuclease; D003023:Cloxacillin; D010068:Oxacillin