A brief report of basic science: the effects of preincisional low-dose ketamine on natural killer cell activity in male Fischer 344 rats after intra-abdominal surgery.
Although the first line of defense in cancer treatment often is surgery, studies suggest that postoperative pain and anesthetic drugs suppress the activity of cells that lyse metastatic cells, that is, natural killer cells. We assessed the affect of low-dose ketamine on natural killer cell activity. The findings are presented in this brief report.
Estes
Savannah
S
US Army Graduate Program in Anesthesia Nursing, Fort Sam Houston, Texas, USA.
Dinh
Tim
T
Garrett
Normalynn
N
D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine / Q000494:pharmacology / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D007813:Laparotomy / Q000009:adverse effects; D018655:Lymphocyte Count; D008297:Male; D009369:Neoplasms / Q000601:surgery; D015399:Nursing Research; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D011292:Premedication / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D000700:Analgesics; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine