title: Pathological findings in dogs with fatal heatstroke.
abstract: Eleven dogs with fatal heatstroke were examined grossly and histopathologically post mortem. All showed multi-organ haemorrhagic diathesis with coagulative necrosis. Hypaeremia and diffuse oedema were observed in the skin (eight dogs), lungs (11), brain (11) and bone marrow (one). Congestion of the splenic pulp (10 dogs) and hepatic sinusoids (nine) was also noted. Necrosis was observed in the mucosa of the small intestine (seven dogs), large intestine (eight), renal tubular epithelium (nine), hepatic parenchyma (eight) and brain neural tissue (four). The results showed that naturally occurring, fatal canine heatstroke induces acute multiple organ lesions affecting most body systems, and suggest that the more prevalent lesions include haemorrhagic diathesis, microthrombosis and coagulative necrosis. These are probable sequels of hyperthermia-induced disseminated intravascular coagulation and systemic inflammatory response syndrome, which lead to multi-organ dysfunction and death.
authors.affiliation: Koret School of Veterinary Medicine, Emergency and Critical Care Unit, Leibniz Institute for Zoo and Wildlife Research, Germany. bruchim@agri.huii.ac.il
authors.forename: Y
authors.initials: Y
authors.lastname: Bruchim
authors.forename: E
authors.initials: E
authors.lastname: Loeb
authors.forename: J
authors.initials: J
authors.lastname: Saragusty
authors.forename: I
authors.initials: I
authors.lastname: Aroch
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D018883:Heat Stroke / Q000473:pathology* / Q000662:veterinary*