Polymorphisms in the regulatory region of the Cyclophilin A gene influence the susceptibility for HIV-1 infection.
BACKGROUND
Previous studies have demonstrated an association between polymorphisms in the regulatory regions of Cyclophilin A (CypA) and susceptibility to both HIV-1 infection and disease progression. Here we studied whether these polymorphisms are associated with susceptibility to HIV-1 infection and disease progression in the Amsterdam Cohort on HIV-1 infection and AIDS (ACS) in a group of men having sex with men (MSM) and drug users (DU).


RESULTS
We screened participants of the ACS for the C1604G and A1650G polymorphisms in the regulatory regions of CypA. The prevalence of the 1650G allele was significantly higher in high risk seronegative MSM than in HIV-1 infected MSM. However, C1604G or A1650G were not associated with the clinical course of infection in MSM of the ACS. Interestingly, participants of the ACS-DU who carried the 1604G allele showed a significantly accelerated progression when viral RNA load above 10(4.5) copies per ml plasma was used as an endpoint in survival analysis.


CONCLUSIONS
The results obtained in this study suggest that the A1650G polymorphism in the regulatory region of the CypA gene may be associated with protection from HIV-1 infection, while the 1604G allele may have a weak association with the clinical course of infection in DU.
Rits
Maarten A N
MA
Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
van Dort
Karel A
KA
Kootstra
Neeltje A
NA
D016022:Case-Control Studies; D015331:Cohort Studies; D021984:Cyclophilin A / Q000235:genetics*; D018450:Disease Progression; D055030:Drug Users / Q000706:statistics & numerical data; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000097:blood / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics*; D012189:Retrospective Studies; D016019:Survival Analysis; D019562:Viral Load; D014779:Virus Replication / Q000502:physiology
D021984:Cyclophilin A