The long and short of membrane fission.
During membrane fission, the GTPase dynamin forms helical assemblies at the neck of membrane buds. Although it has been proposed that fission results from the constriction of the dynamin helix, new work by Bashkirov et al. (2008) and Pucadyil and Schmid (2008) unexpectedly shows that helix disassembly is also necessary for membrane fission.
Roux
Aurélien
A
Laboratoire Physico-Chimie Curie, CNRS, Institut Curie, 75248 Paris Cedex 05, France. aurelien.roux@curie.fr
Antonny
Bruno
B
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism; D008954:Models, Biological
D008051:Lipid Bilayers; D034281:Dynamins