Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer.
Breast cancer metastasis suppressor 1 (BRMS1) is a metastasis suppressor gene in several solid tumors. The role of BRMS1 in non-small cell lung cancer (NSCLC) is not well established. To assess in vitro and in vivo metastatic behavior H1299 NSCLC cells stably expressing BRMS1 or a vector control were created. BRMS1 expression significantly decreases both migration and invasion of NSCLC cells in vitro. Importantly, in flank xenografts, BRMS1 suppresses the formation of pulmonary and hepatic metastases but does not significantly affect primary tumor growth. To evaluate whether BRMS1 is related to the progression of NSCLC, we examined BRMS1 expression in human NSCLC. Both BRMS1 mRNA and protein levels are diminished in NSCLC compared to adjacent non-cancerous lung. BRMS1 expression is also lower in squamous cell carcinoma compared to adenocarcinoma. Moreover, preservation of tumor BRMS1 expression is associated with improved patient survival. Thus, BRMS1 functions as a metastasis suppressor and may be a prognostic indicator for human NSCLC.
Smith
Philip W
PW
Department of Surgery, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
Liu
Yuan
Y
Department of Surgery, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
Siefert
Suzanne A
SA
Department of Surgery, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
Moskaluk
Christopher A
CA
Department of Pathology, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
Petroni
Gina R
GR
Department of Public Health Sciences, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
Jones
David R
DR
Department of Surgery, University of Virginia, Charlottesville Virginia, P.O. Box 800679, Charlottesville, VA 22908-0679, United States.
D000368:Aged; D000818:Animals; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D009363:Neoplasm Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis; D012097:Repressor Proteins; D012907:Smoking / Q000378:metabolism
C410024:BRMS1 protein, human; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D012097:Repressor Proteins