Impact of perinatal corticosteroids on neuromotor development and outcome: review of the literature and new meta-analysis.
Perinatal corticosteroids are like a double-edged sword. On the one hand, they reduce risk for major morbidity and even mortality; on the other hand, they modify growth and development of body systems, with short- and long-term consequences. The relationship between corticosteroids and neurodevelopmental outcome has been extensively studied in randomized controlled trials, cohort and case-control studies and meta-analyses. In this article we attempt accurately to reflect current clinical equipoise on this issue by reviewing the most recent literature and adding a new meta-analysis on the relationship between postnatal dexamethasone and cerebral palsy and neurodevelopmental impairment.
Shinwell
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Department of Neonatology, Kaplan Medical Center, Rehovot and Hebrew University, Jerusalem, Israel. eric_s@clalit.org.il
Eventov-Friedman
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D001997:Bronchopulmonary Dysplasia / Q000517:prevention & control; D002657:Child Development / Q000187:drug effects*; D003907:Dexamethasone / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015201:Meta-Analysis as Topic; D018743:Perinatal Care; D011247:Pregnancy; D011295:Prenatal Care; D016032:Randomized Controlled Trials as Topic
D005938:Glucocorticoids; D003907:Dexamethasone