Broadly applicable synthesis of 1,2,4,5-tetraoxanes.
Re(2)O(7) is a mild and efficient catalyst for the high-yielding condensation of 1,1-dihydroperoxides with ketones or aldehydes to form 1,2,4,5-tetraoxanes, including targets not easily prepared via existing methodology. When applied in tandem with a recently reported Re(VII)-catalyzed synthesis of 1,1-dihydroperoxides, the reaction provides a high-yielding one-pot conversion of ketones or aldehydes to tetraoxanes.
Ghorai
Prasanta
P
Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska 68588-0304, USA.
Dussault
Patrick H
PH
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry; D013237:Stereoisomerism; D045568:Tetraoxanes / Q000138:chemical synthesis* / Q000737:chemistry
D000447:Aldehydes; D007659:Ketones; D010545:Peroxides; D045568:Tetraoxanes; D012211:Rhenium