title: A discrepancy of Chlamydia trachomatis incidence and prevalence trends in Finland 1983-2003.
abstract: BACKGROUND
  Reported rates of Chlamydia trachomatis are on the rise contradicting the declining rates of C. trachomatis associated reproductive sequelae in Western countries. Population based evaluation of the real trend of C. trachomatis infection is important to contemplate prevention efforts. We studied C. trachomatis occurrence during the past 20 years in Finland comparing incidence rate data based on serology and reported C. trachomatis laboratory notifications.
  
  
  METHODS
  A random sample of 7999 women with two consecutive pregnancies within five years was selected from the population of the Finnish Maternity Cohort (FMC) serum bank stratified by calendar year and age. C. trachomatis IgG antibodies were determined by a standard peptide-ELISA. The reported incidence rates of C. trachomatis infections based on case notifications were obtained from the National Registry of Infectious Diseases (NIDR).
  
  
  RESULTS
  C. trachomatis seroprevalence rates decreased significantly from 1983 to 2003 both in women under 23 years of age (23.3% to 9.2%) and in women between 23-28-years of age (22.2% to 12.6%). However, seroconversion rates increased from 31 per 10000 person years in 1983-85 to 97 per 10000 person years in 2001-2003 (incidence rate ratio 3.2, 95% CI, 1.1-8.7) among the older age group. Seroconversion rate was highest (264) in 1983-1985 in the younger age-group, then declined and subsequently increased again (188) in 2001-2003. The incidence based on seroconversions was in agreement with the reported incidence rates in both age groups.
  
  
  CONCLUSIONS
  C. trachomatis seroprevalence rate decreased during 1983-2003 among fertile-aged women in Finland. During the same time period incidence rates based both on seroconversions and reported laboratory notifications of diagnosed C. trachomatis infections increased. The discrepancy between the C. trachomatis incidence and seroprevalence trends warrants further studies.
authors.affiliation: National Public Health Institute, Oulu and Helsinki, Finland. erika.lyytikainen@ktl.fi
authors.forename: Erika
authors.initials: E
authors.lastname: Lyytikäinen
authors.forename: Marjo
authors.initials: M
authors.lastname: Kaasila
authors.forename: Eija
authors.initials: E
authors.lastname: Hiltunen-Back
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Tasanen
authors.forename: Heljä-Marja
authors.initials: HM
authors.lastname: Surcel
authors.forename: Pentti
authors.initials: P
authors.lastname: Koskela
authors.forename: Jorma
authors.initials: J
authors.lastname: Paavonen
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D002690:Chlamydia Infections / Q000453:epidemiology* / Q000276:immunology; D002692:Chlamydia trachomatis / Q000276:immunology; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000276:immunology; D015995:Prevalence; D016036:Seroepidemiologic Studies; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G