[Predictors of the progress of latent tuberculosis to clinically active one].
The question recently arises as to the diagnosis of tuberculous infection at early stages of its development. Tuberculin diagnosis ranks below due to the rise ofcomorbidity, including allergic diseases. There is increasing evidence for the leading role in the development of this or that type of tuberculous infection. A mathematical model was used to identify 5 major of the 35 laboratory parameters characterizing the immune profile. The equations of classifying discriminant functions derived by the chosen immunological parameters make it possible to formalize data strictly and to organize an immunological screening with a high degree of accuracy in children with unchanged tuberculin sensitivity, without making compound statistical calculations. This fact can meet the requirements of immunological prediction of the development of tuberculosis in children.
Tiul'kova
T E
TE
Kornachev
A S
AS
Chugaev
Iu P
IuP
Kashuba
E A
EA
Kulikova
I B
IB
Beloborodova
N G
NG
Andreeva
L V
LV
Kozlova
A V
AV
Kashuba
E V
EV
Khmeleva
E F
EF
Molokova
O M
OM
D000293:Adolescent; D015703:Antigens, CD / Q000276:immunology; D002648:Child; D018450:Disease Progression; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D011446:Prospective Studies; D012720:Severity of Illness Index; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology*
D015703:Antigens, CD; D007073:Immunoglobulin E