title: Comparison of adverse effects following immunization with vaccine containing whole-cell vs. acellular pertussis components.
abstract: The article presents comparative study of the incidence of adverse effects following vaccinations with whole cell and acellular pertussis vaccines, based on data collected in obligatory routine surveillance of AEFI in the period of 2001-2005 in Poland. Comparisons done in children less then 2-years-old show in general about twice as high incidence of adverse effects following the whole-cell than the acellular vaccine. The biggest rate of proportions (RR = 4,75) was observed for high pitch cry. There was no significant difference in incidence of the most severe reactions, including encephalopathy and nonfebrile seizures, and there was no significant difference in allergic reactions.
authors.affiliation: Department of Epidemiology, National Institute of Public Health-PZH, Warszawa. azielinski@pzh.gov.pl
authors.forename: Andrzej
authors.initials: A
authors.lastname: Zieliński
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rosińska
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D002493:Central Nervous System Diseases / Q000139:chemically induced; D002669:Child Welfare / Q000706:statistics & numerical data; D002675:Child, Preschool; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007229:Infant Welfare / Q000706:statistics & numerical data; D007231:Infant, Newborn; D008297:Male; D010567:Pertussis Vaccine / Q000009:adverse effects*; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects* / Q000706:statistics & numerical data*; D022282:Vaccines, Acellular / Q000009:adverse effects*; D014917:Whooping Cough / Q000517:prevention & control
chemical_list: D015721:Diphtheria-Tetanus-Pertussis Vaccine; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D010567:Pertussis Vaccine; D022282:Vaccines, Acellular