Thiazole Orange derivatives: synthesis, fluorescence properties, and labeling cancer cells.
A series of Thiazole Orange (TO) derivatives were synthesized and modified by introducing different substitutional groups on benzothiazole and 4-methylquinoline All the TO derivatives were confirmed by (1)HNMR and MS. TO derivative bearing NH(2)- was modified by folic acid and used to label breast cancer cells. The phenomenon of fluorescence enhancement was shown by the fluorescence spectrums of TO derivatives and micrographs of the labeled breast cancer cells. It offered a new try in the aspect of labeling cells by the embedded dyes.
Fei
Xuening
X
Department of Material Science and Engineering, Tianjin Institute of Urban Construction, Tianjin 300384, China. xueningfei@126.com
Gu
Yingchun
Y
Ban
Ying
Y
Liu
Zhijun
Z
Zhang
Baolian
B
D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D001943:Breast Neoplasms / Q000473:pathology*; D045744:Cell Line, Tumor; D022082:Cellular Structures; D005260:Female; D005453:Fluorescence; D005456:Fluorescent Dyes; D006801:Humans; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D052160:Benzothiazoles; D005456:Fluorescent Dyes; D011804:Quinolines; C051000:thiazole orange