title: Expression of S100A4, E-cadherin, alpha- and beta-catenin in gastric adenocarcinoma.
abstract: OBJECTIVE
  This investigation aimed to elucidate the expression patterns of S100A4 and adhesion molecules in gastric carcinoma and to estimate their correlation with clinicopathologic parameters.
  
  
  METHODS
  The expression of S100A4, E-cadherin, alpha- and beta-catenin was studied in 251 gastric carcinoma specimens through immunohistochemical staining.
  
  
  RESULTS
  The positive expression of S100A4 was significantly associated with advanced gastric cancer, higher pTNM stage, and poorer survival rates, especially when present in nuclear staining. The reduced expression of adhesion molecules was significantly associated with diffuse type of gastric cancer. The reduced expression of beta-catenin was significantly associated with lymph node metastasis, especially in early gastric cancer. The coexpression status of S100A4-positive and reduced beta-catenin was significantly associated with larger tumor size, advanced tumor depth, and higher pTNM stage.
  
  
  CONCLUSIONS
  S100A4 and adhesion molecule expression may be a useful prognostic marker for individual gastric cancer patients.
authors.affiliation: Department of Surgery, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Korea.
authors.forename: Chan-Seok
authors.initials: CS
authors.lastname: Yoon
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Hyung
authors.forename: Ju-Han
authors.initials: JH
authors.lastname: Lee
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Chae
authors.forename: Nam Hee
authors.initials: NH
authors.lastname: Won
authors.forename: Bum-Woo
authors.initials: BW
authors.lastname: Yeom
authors.forename: Jong Sang
authors.initials: JS
authors.lastname: Choi
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology; D051178:alpha Catenin / Q000032:analysis*; D051176:beta Catenin / Q000032:analysis*
chemical_list: D015820:Cadherins; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; D051178:alpha Catenin; D051176:beta Catenin; C077591:S100A4 protein, human