[Effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction].
OBJECTIVE
To investigate the effects of carvedilol and metoprolol on cardiac fibrosis in rats with experimental myocardial infarction (MI).


METHODS
MI was induced in male Sprague-Dawley rats by ligating the left coronary artery. Rats randomly received saline, carvedilol (10 mg.kg(-1).d(-1)) or metoprolol (20 mg.kg(-1).d(-1)) beginning at 4 weeks post MI for 8 weeks per gavage. Sham-operated rats serve as control. Collagen perivascular circumferential collagen area (PCVA), peri-coronary circumferential collagen area (VLCA) and interstitial collagen volume fraction (ICVF) as well as myocardial hydroxyproline content were determined after hemodynamic measurements at the study end.


RESULTS
LVEDP were significantly lower and +/- dp/dt significantly higher in carvedilol and metoprolol treated MI rats than that in saline treated MI rats. Myocardial hydroxyproline, PCVA/VLCA ratio and ICVF were significantly reduced in metoprolol, more significantly reduced in carvedilol treated MI rats compared to saline treated MI rats (all P < 0.05).


CONCLUSIONS
Metoprolol and carvedilol could decrease the concentration of hydroxyproline and ICVF in MI rats.
Sun
Tao
T
Emergency Center, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029, China.
Shen
Lu-Hua
LH
Chen
Hui
H
Li
Hong-Wei
HW
Guo
Chun-Yan
CY
Li
Zhi-Zhong
ZZ
Tang
Chao-Shu
CS
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D003094:Collagen / Q000378:metabolism; D004195:Disease Models, Animal; D005355:Fibrosis; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D009203:Myocardial Infarction / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D011412:Propanolamines / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D003094:Collagen; D008790:Metoprolol; D006909:Hydroxyproline