Treacher Collins syndrome: an undescribed characteristic of the condition and its management with botulinum toxin and surgery.
Mandibulofacial dysostosis (Treacher Collins syndrome) is associated with clinical abnormalities of structures derived from the first and second branchial arches, including antimongoloid slant of palpebral fissures, colobomas of the lower eyelid, eyelash malformations, and malar and mandibular defects. We describe an unusual clinical feature associated with colobomas of the lower eyelids, in a patient with mandibulofacial dysostosis, successfully treated with botulinum toxin and subsequent surgery.
Warner
Robert M
RM
Department of Plastic Surgery, George Eliot Hospital, Nuneaton, United Kingdom. rmwarner@hotmail.com
Fagan
John M
JM
Das-Gupta
Rana
R
D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D002610:Cheek / Q000601:surgery; D003103:Coloboma / Q000188:drug therapy* / Q000601:surgery; D005143:Eyelids / Q000187:drug effects / Q000601:surgery; D005152:Facial Muscles / Q000187:drug effects / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008342:Mandibulofacial Dysostosis / Q000188:drug therapy* / Q000601:surgery; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D012904:Smiling; D055815:Young Adult
D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A