Enhanced expressions of sodium-glucose cotransporters in the kidneys of diabetic Zucker rats.
Diabetes-mediated changes in mRNA expressions of kidney glucose transporters SGLT1 and SGLT2 were investigated in Zucker rats. SGLTs expressions in pre-diabetic obese rats were similar to leans. SGLT1 and SGLT2 levels in diabetic obese rats were 1.6 (P<0.03) and 4.8 (P<0.002) folds higher than age-matched leans, respectively.
Tabatabai
Niloofar M
NM
Division of Endocrinology, Metabolism and Clinical Nutrition, Medical College of Wisconsin, Milwaukee, WI 53226-0509, USA. ntabatab@mcw.edu
Sharma
Mukut
M
Blumenthal
Samuel S
SS
Petering
David H
DH
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000235:genetics*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D011924:Rats, Zucker; D020133:Reverse Transcriptase Polymerase Chain Reaction; D051247:Sodium-Glucose Transport Proteins / Q000235:genetics*; D051269:Sodium-Glucose Transporter 1 / Q000235:genetics; D051297:Sodium-Glucose Transporter 2 / Q000235:genetics
D051247:Sodium-Glucose Transport Proteins; D051269:Sodium-Glucose Transporter 1; D051297:Sodium-Glucose Transporter 2