title: Inter-racial, gender and aging influences in the length of anterior commissure-posterior commissure line.
abstract: OBJECTIVE
  The length of anterior-posterior commissure (AC-PC) in racial groups, age, gender of patients with deep brain stimulation (DBS) and pallidotomy were investigated.
  
  
  METHODS
  From January 1996 to December 2003, 211 patients were treated with DBS and pallidotomy. There were 160 (76%) Caucasians, 35 (17%) Hispanics, 12 (5%) Asians and 4 Blacks (2%). There were 88 males and 52 females in DBS-surgery group and 44 males, 27 females in pallidotomy group. Mean age was 58 year-old. There were 19 males and 19 females and mean age was 54.7 years in the control group. Measurements were made on MRI and @Target software.
  
  
  RESULTS
  The average AC-PC distance was 24.89 mm (range 32 to 19), which increased with aging until 75 years old in Caucasian and also increased with aging in Hispanic, but the AC-PC distance peaked at 45 years old in Hispanic. The order of AC-PC distance were 25.2+/-2 mm in Caucasian, 24.6+/-2.24 mm in Asian, 24.53 mm in Black, 23.6+/-1.98 mm in Hispanic. The average AC-PC distance in all groups was 24.22 mm in female who was mean age of 56.35, 25.28 mm in male who was mean age of 60.19 and 24.5+/-2 mm in control group that was excluded because of the difference of thickness of slice. According to multiple regression analysis, the AC-PC distance was significantly correlated with age, race, and gender.
  
  
  CONCLUSIONS
  The AC-PC distance is significantly correlated with age, gender, and race. The atlas of functional stereotaxis would be depended on the variation of indivisual brain that can influenced by aging, gender, and race.
authors.affiliation: Department of Neurosurgery , College of Medicine, Hallym University, Seoul, Korea.
authors.forename: Tae-One
authors.initials: TO
authors.lastname: Lee
authors.forename: Hyung-Sik
authors.initials: HS
authors.lastname: Hwang
authors.forename: Antonio
authors.initials: A
authors.lastname: De Salles
authors.forename: Carlos
authors.initials: C
authors.lastname: Mattozo
authors.forename: Alessandra G
authors.initials: AG
authors.lastname: Pedroso
authors.forename: Eric
authors.initials: E
authors.lastname: Behnke