Acquired cutis laxa associated with heavy chain deposition disease.
Acquired cutis laxa (generalized acquired elastolysis) is a condition of unknown etiology characterized by a degeneration of elastic fibers in the skin, resulting in laxity with reduced elastic recoil. We describe a patient with acquired cutis laxa associated with an underlying heavy chain deposition disease. Direct immunofluorescence testing of lesional skin demonstrated immunoglobulin G deposition on elastic fibers, suggesting that in some cases, cutis laxa may have an immune-mediated etiopathogenesis.
Harrington
Cynthia R
CR
Department of Dermatology, The University of Texas Southwestern Medical Center, Dallas, Texas 75390-9190, USA.
Beswick
Tracy C
TC
Susa
Joseph S
JS
Pandya
Amit G
AG
D000328:Adult; D003483:Cutis Laxa / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006362:Heavy Chain Disease / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D012867:Skin / Q000378:metabolism* / Q000473:pathology
D007074:Immunoglobulin G