title: The impact of out-migrants and out-migration on the HIV/AIDS epidemic: a case study from south-west India.
abstract: OBJECTIVE
  Seasonal migration may be an important driver of the HIV epidemic in India; however, migrant sexual behaviour data are limited. This study assessed the extent to which migration could explain heterogeneity in HIV prevalence in Bagalkot district, in Karnataka state, India, examining important migration-related risk factors for HIV transmission and implications for prevention.
  
  
  METHODS
  We used mathematical modelling to explore the potential impact of different seasonal migration patterns on HIV prevalence.
  
  
  METHODS
  A deterministic compartmental mathematical model of heterosexually transmitted HIV infection was developed. Six migration scenarios were explored, depending on which population migrated (men/clients only/female sex workers; FSW), and which local population determined the demand for commercial sex while migrants were away.
  
  
  RESULTS
  The impact of migration varied substantially across the six migration scenarios. Migration was unlikely to explain heterogeneity in HIV prevalence unless a fraction of all men migrated and local FSW drove the demand for commercial sex. Even with very high-risk migrant sexual behaviour in the migration destination, targeting interventions at 30%-100% of local core groups could prevent a maximum of 12%-40% of new infections (87% effective condoms), from 2004-2015. Targeting migrants locally and at their destination could have up to 1.6-times the impact of targeting migrants only at their destination.
  
  
  CONCLUSIONS
  Results suggest that core group interventions introduced locally because of the difficulty of reaching migrant populations could still be beneficial. Understanding how local sexual networks change during migration is crucial for understanding the impact of migration on HIV transmission, and for designing HIV preventive interventions.
authors.affiliation: School of Population and Public Health, University of British Columbia, Vancouver, Canada. kdeering@interchange.ubc.ca
authors.forename: Kathleen N
authors.initials: KN
authors.lastname: Deering
authors.forename: Peter
authors.initials: P
authors.lastname: Vickerman
authors.forename: Stephen
authors.initials: S
authors.lastname: Moses
authors.forename: Banadakoppa M
authors.initials: BM
authors.lastname: Ramesh
authors.forename: James F
authors.initials: JF
authors.lastname: Blanchard
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Boily
mesh_terms: D004196:Disease Outbreaks; D004812:Epidemiologic Methods; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008954:Models, Biological; D012309:Risk-Taking; D012621:Seasons; D011477:Sex Work / Q000706:statistics & numerical data; D012725:Sexual Behavior / Q000706:statistics & numerical data; D014171:Transients and Migrants / Q000523:psychology / Q000706:statistics & numerical data*; D047568:Unsafe Sex / Q000706:statistics & numerical data