[Circulating cytokine measurements by protein chips in patients with acute coronary syndrome].
OBJECTIVE
To observe the feasibility of measuring multiple circulating cytokines by protein chips in patients with acute coronary syndrome (ACS).


METHODS
Circulating cytokines were determined by protein chips in 50 control cases and 104 ACS cases of unstable angina pectoris (UA, n = 50) and acute myocardial infarction (AMI, n = 54) cases.


RESULTS
The levels of serum MMP-9, sCD40L, CRP, IL-6, H-FABP, cTnI and plasma IL-8, NT-proBNP, sVCAM-1, ET-1 in ACS group were significantly higher than those in the control group (all P < 0.01). Serum H-FABP and cTnI were significantly higher in AMI patients than in UA patients (P < 0.01). Serum MMP-9, sCD40L, CRP, IL-6 and plasma sVCAM-1, ET-1 tended to be higher in AMI patients as compared to UA patients (all P > 0.05). Serum MMP-9, sCD40L, and H-FABP were positively correlated with the severity of angina(r = 0.653, r = 0.745, r = 0.933, P < 0.01, respectively). Serum MMP-9, sCD40L, and H-FABP increased in proportion to the levels of Braunwald angina classes in UA patients (angina class I < angina class II < angina class III, P < 0.01).


CONCLUSIONS
Circulating cytokines were significantly increased in ACS patients and positively correlated to Braunwald angina classes in UA patients.
Mao
Hua
H
Department of Cardiology, First People's Hospital, Guiyang 550002, China. maobaosisiley@yahoo.com.cn
Liu
Ting-Zhu
TZ
Wen
Mei
M
Chen
Jing-Jing
JJ
Li
Ling
L
Zhu
Jin-Kun
JK
D054058:Acute Coronary Syndrome / Q000097:blood*; D000368:Aged; D000787:Angina Pectoris / Q000097:blood; D000789:Angina, Unstable / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D040081:Protein Array Analysis
D016207:Cytokines; D023201:CD40 Ligand; D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9