Search for serum biomarkers associated with abdominal aortic aneurysm growth--a pilot study.
BACKGROUND
Serological biomarkers could reflect asymptomatic infrarenal aortic aneurysm (AAA) activity and guide patient management.


METHODS
Serum concentrations of C-reactive protein (CRP), alpha 1-antitrypsin and lipoprotein(a) were measured in blood samples from 35 AAA patients and 35 controls and correlated with the aortic diameter and AAA growth in the previous 12 months. We found a positive correlation between CRP and AAA diameter (r=0.46; p=0.007) and alpha 1-antitrypsin and AAA growth (r=0.55; p=0.004).


CONCLUSIONS
Alpha 1-antitrypsin may be a promising biomarker of AAA growth.
Vega de Céniga
M
M
Department of Angiology and Vascular Surgery, Hospital de Galdakao-Usansolo, Bizkaia, Spain. melina.vegadeceniga@osakidetza.net
Esteban
M
M
Quintana
J M
JM
Barba
A
A
Estallo
L
L
de la Fuente
N
N
Viviens
B
B
Martin-Ventura
J L
JL
D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000473:pathology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010865:Pilot Projects; D000515:alpha 1-Antitrypsin / Q000097:blood*
D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017270:Lipoprotein(a); D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein