Giant proteins: sensing tension with titin kinase.
Recent studies at the single-molecule level show how signaling from the giant protein titin can be triggered by direct mechanical activation of its kinase domain.
Tskhovrebova
Larissa
L
Astbury Centre for Structural Molecular Biology, Institute for Molecular and Cellular Biology, Leeds University, Leeds, UK.
Trinick
John
J
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D064211:Connectin; D018625:Microscopy, Atomic Force; D009119:Muscle Contraction / Q000502:physiology; D009124:Muscle Proteins / Q000737:chemistry* / Q000502:physiology*; D011494:Protein Kinases / Q000737:chemistry* / Q000502:physiology*; D012518:Sarcomeres / Q000201:enzymology / Q000502:physiology*; D015398:Signal Transduction
D064211:Connectin; D009124:Muscle Proteins; D000255:Adenosine Triphosphate; D011494:Protein Kinases