Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E.
The stability of ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate in topical formulations was investigated by direct reverse phase high performance liquid chromatography after sample dilution with a suitable buffer - organic solvent mixture. Ascorbyl palmitate, sodium ascorbyl phosphate and magnesium ascorbyl phosphate are derivatives of ascorbic acid which differ in hydrolipophilic properties. They are widely used in cosmetic and pharmaceutical preparations. According to the results, ascorbyl esters showed significant differences: sodium ascorbyl phosphate and magnesium ascorbyl phosphate are more stable derivatives of vitamin C than ascorbyl palmitate and may be easily used in cosmetic products.
Segall
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Cátedra de Control de Calidad de Medicamentos, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, 1113 Buenos Aires, Argentina. asegall@ffyb.uba.ar
Moyano
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MA
D000975:Antioxidants / Q000737:chemistry; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000737:chemistry; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D007700:Kinetics; D008063:Thioctic Acid / Q000737:chemistry*; D014801:Vitamin A / Q000737:chemistry*; D014810:Vitamin E / Q000737:chemistry*; D014815:Vitamins / Q000737:chemistry*
D000975:Antioxidants; D003358:Cosmetics; D004655:Emulsions; D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D008063:Thioctic Acid; D001205:Ascorbic Acid