A case of acute hepatitis with Mycoplasma pneumoniae infection and transient depression of multiple coagulation factors.
We report a case of acute severe hepatitis with Mycoplasma pneumoniae (M. pneumoniae) infection and transient depression of multiple coagulation factors. A 5-year-old boy, previously healthy, was admitted with pneumonia. M. pneumoniae infection was confirmed by serology testing. Liver enzymes were elevated on admission without any past medical history. After treatment with azithromycin for 3 days, pneumonia improved, but the hepatitis was acutely aggravated. Partial thromboplastin time (PTT) was prolonged and depression of multiple coagulation factors developed. Liver biopsy revealed features consistent with acute hepatitis. A week later, liver enzymes were nearly normalized spontaneously. Normalization of prolonged PTT and coagulation factors were also observed several months later. This may be the first case of transient depression of multiple coagulation factors associated with M. pneumoniae infection.
Chang
Joo Hee
JH
Department of Pediatrics, Inha University College of Medicine, 7-206, 3-ga, Sinheung-dong, Jung-gu, Incheon 400-711, Korea.
Kwon
Young Se
YS
Kim
Bok Ki
BK
Son
Byong Kwan
BK
Lee
Jee Eun
JE
Lim
Dae Hyun
DH
Kim
Soon Ki
SK
Kim
Joon Mi
JM
Kang
Sung Kil
SK
D000208:Acute Disease; D001779:Blood Coagulation Factors / Q000378:metabolism; D002675:Child, Preschool; D006506:Hepatitis A / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D009177:Mycoplasma pneumoniae / Q000472:pathogenicity; D010314:Partial Thromboplastin Time; D011019:Pneumonia, Mycoplasma / Q000097:blood / Q000150:complications*
D001779:Blood Coagulation Factors