title: Long-range diffusion of hyperpolarized 3He in rats.
abstract: Based on a stimulated-echo technique, a method to construct an apparent diffusion coefficient (ADC) map of hyperpolarized (3)He in a long-range diffusion scale is presented with a phase-cycle alternative to remove all unwanted echoes. The approach was successfully applied to determine in vivo diffusion constants in rat lungs. The ADC values in healthy rats show a good agreement with reported values for diffusion times of approximately. These long diffusivity measurements may be sensitive to detect emphysema progression or tissue remodeling and thus have enormous potential for the diagnosis and tracking of disease progression and for drug evaluation.
authors.affiliation: Departamento de Química Física II, Facultad de Farmacia, Universidad Complutense Madrid, CIBER de enfermedades respiratorias, Madrid, Spain.
authors.forename: Ignacio
authors.initials: I
authors.lastname: Rodríguez
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Pérez-Sánchez
authors.forename: Germán
authors.initials: G
authors.lastname: Peces-Barba
authors.forename: Thomas
authors.initials: T
authors.lastname: Kaulisch
authors.forename: Detlef
authors.initials: D
authors.lastname: Stiller
authors.forename: Jesús
authors.initials: J
authors.lastname: Ruiz-Cabello
mesh_terms: D000465:Algorithms; D000818:Animals; D003287:Contrast Media / Q000737:chemistry; D004058:Diffusion; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006371:Helium / Q000737:chemistry*; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007477:Ions; D007554:Isotopes / Q000737:chemistry; D008168:Lung / Q000033:anatomy & histology* / Q000737:chemistry*; D008297:Male; D019275:Radiopharmaceuticals / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D007477:Ions; D007554:Isotopes; D019275:Radiopharmaceuticals; D006371:Helium