Here comes the sun: recognition of UV-damaged DNA.
The first step in the repair of DNA damage is lesion detection. In this issue, Scrima et al. (2008) report the structure of the complex of DNA Damage-Binding Protein 1 (DDB1) and DDB2 bound to a DNA photodimer, providing critical insight into the repair of DNA damage caused by ultraviolet light.
Chu
Gilbert
G
Departments of Medicine and Biochemistry, CCSR1145, Division of Oncology, Stanford University Medical Center, Stanford, CA 94305-5151, USA.
Yang
Wei
W
D004260:DNA Repair; D006801:Humans; D011740:Pyrimidine Dimers / Q000378:metabolism; D013472:Sunlight; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000378:metabolism
D011740:Pyrimidine Dimers