Antisickling properties of divanilloylquinic acids isolated from Fagara zanthoxyloides Lam. (Rutaceae).
Fagara zanthoxyloides Lam. (syn. Zanthoxylum zanthoxyloides) (Rutaceae) is the most cited Fagara species for the treatment and the prevention of sickle cell disease crisis. Sickle cell anemia (SCA) is a public health problem in many countries particularly in Africa. The present study was designed to evaluate the antisickling properties of three isomeric divanilloylquinic acids (3,4-O-divanilloylquinic acid or burkinabin A; 3,5-O-divanilloylquinic acid or burkinabin B and 4,5-O-divanilloylquinic acid or burkinabin C) identified previously by LC/MS/NMR analysis in the root bark of F. zanthoxyloides [Ouattara et al., 2004. LC/MS/NMR analysis of isomeric divanilloylquinic acids from the root bark of Fagara zanthoxyloides Lam. Phytochemistry 65, 1145-1151]. The three isomers showed interesting antisickling properties which increased from burkinabins A to C.
Ouattara
B
B
Institut de Recherche en Sciences de la Santé (IRSS), Département Médecine Pharmacopée Traditionnelle, Pharmacie 03 BP7192 Ouagadougou 03, Burkina Faso.
Jansen
O
O
Angenot
L
L
Guissou
I P
IP
Frédérich
M
M
Fondu
P
P
Tits
M
M
D000349:Africa; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000986:Antisickling Agents / Q000627:therapeutic use*; D004205:Cromolyn Sodium / Q000627:therapeutic use; D006801:Humans; D007536:Isomerism; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000627:therapeutic use; D032106:Zanthoxylum / Q000737:chemistry
D000986:Antisickling Agents; D010936:Plant Extracts; C539924:burkinabin A; C539925:burkinabin B; C539926:burkinabin C; D011801:Quinic Acid; D014641:Vanillic Acid; D004205:Cromolyn Sodium