Gastric and duodenal antiulcer activity of alkaloids: a review.
Peptic ulcer disease is a deep gastrointestinal erosion disorder that involves the entire mucosal thickness and can even penetrate the muscular mucosa. Numerous natural products have been evaluated as therapeutics for the treatment of a variety of diseases, including this one. These products usually derive from plant and animal sources that contain active constituents such as alkaloids, flavonoids, terpenoids, tannins and others. The alkaloids are natural nitrogen-containing secondary metabolites mostly derived from amino acids and found in about 20% of plants. There has been considerable pharmacological research into the antiulcer activity of these compounds. In this work we review the literature on alkaloids with antiulcer activity, which covers about sixty-one alkaloids, fifty-five of which have activity against this disease when induced in animals.
de Sousa Falcão
Heloina
H
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, UFPB, João Pessoa, PB, Brazil. heloinafalcao@yahoo.com.br
Leite
Jacqueline Alves
JA
Barbosa-Filho
José Maria
JM
de Athayde-Filho
Petrônio Filgueiras
PF
de Oliveira Chaves
Maria Célia
MC
Moura
Marcelo Dantas
MD
Ferreira
Anderson Luiz
AL
de Almeida
Ana Beatriz Albino
AB
Souza-Brito
Alba Regina Monteiro
AR
de Fátima Formiga Melo Diniz
Margareth
M
Batista
Leônia Maria
LM
D000470:Alkaloids / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy*; D023421:Models, Animal; D013276:Stomach Ulcer / Q000188:drug therapy*
D000470:Alkaloids; D000897:Anti-Ulcer Agents