Serum adiponectin is associated with family history of diabetes independently of obesity and insulin resistance in healthy Korean men and women.
BACKGROUND
Adiponectin has been reported as a new risk factor for the development of diabetes. However, it is not clear whether adiponectin levels are associated with family history of diabetes (FHD).


OBJECTIVE
The objective of this study was to measure the independent association of serum adiponectin with FHD in relation to insulin resistance and obesity.


METHODS
In 2006, a cross-sectional study was conducted in which waist circumference (WC), body mass index (BMI), and serum adiponectin were measured in 5919 healthy Korean men and women. Multiple linear regression models were used to assess the association of serum adiponectin levels with FHD. The population was classified into two groups according to median values for each of the following variables: WC, BMI, and homeostasis model assessment of insulin resistance (HOMA-IR).


RESULTS
The positive FHD group had higher HOMA-IR and lower adiponectin levels in both men and women than those without FHD. Adiponectin levels were significantly associated with FHD in men and women respectively, after adjusting for age, BMI, and alcohol consumption (P=0.0123 and 0.0004). The relationship between adiponectin and FHD was similar between the high and low insulin resistance, BMI, and WC groups in male non-smokers and in all Korean women.


CONCLUSIONS
These results confirm that adiponectin levels are associated with FHD. These data also suggest that the association of serum adiponectin with FHD may be independent of obesity and insulin resistance.
Sull
Jae Woong
JW
Graduate School of Public Health, Institute for Health Promotion, Yonsei University, Seoul, Republic of Korea.
Kim
Hee Jin
HJ
Yun
Ji Eun
JE
Kim
Grace
G
Park
Eun Jung
EJ
Kim
Soriul
S
Lee
Hee Yeon
HY
Jee
Sun Ha
SH
D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D007723:Korea; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D055815:Young Adult
C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D014280:Triglycerides; D002784:Cholesterol