title: Corneal architecture of femtosecond laser and microkeratome flaps imaged by anterior segment optical coherence tomography.
abstract: OBJECTIVE
  To assess and compare the morphology of laser in situ keratomileusis flaps (LASIK) created by a 60 kHz femtosecond laser and a mechanical microkeratome.
  
  
  METHODS
  Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
  
  
  METHODS
  Anterior segment optical coherence tomography (AS-OCT) (Visante) was used to assess 1 week postoperatively the morphology of 20 LASIK flaps created with the IntraLase femtosecond laser or the Zyoptix XP microkeratome. The flap diameter and flap thickness were assessed at 20 measuring points across each flap. First, the repeatability of the AS-OCT flap measurement was evaluated. On this basis, the dimensions of femtosecond laser flaps and microkeratome flaps were tested and their regularity, reproducibility, and accuracy compared.
  
  
  RESULTS
  The method was approved with a repeatability of maximum 8.9 mum. The femtosecond laser flaps were more regular than the microkeratome flaps (P = .02). The reproducibility of flap morphology was not different in the central 1.0 mm radius area (P = .26); however, the femtosecond laser was significantly more precise than the microkeratome in the peripheral area (P = .001). The mean thickness of the femtosecond laser flap was significantly more accurate than the mean thickness of the microkeratome flap (P = .01), with a mean deviation of +16.9 mum and 40.8 mum, respectively.
  
  
  CONCLUSIONS
  The flap architecture created with the femtosecond laser was more regular and accurate than the flap architecture created with the microkeratome.
authors.affiliation: Department of Ophthalmology, Johann Wolfgang Goethe-University, Frankfurt am Main, Germany.
authors.forename: Burkhard
authors.initials: B
authors.lastname: von Jagow
authors.forename: Thomas
authors.initials: T
authors.lastname: Kohnen
mesh_terms: D000328:Adult; D003319:Corneal Stroma / Q000473:pathology*; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000379:methods*; D054018:Lasers, Excimer / Q000627:therapeutic use*; D053844:Lasers, Solid-State; D008297:Male; D009216:Myopia / Q000601:surgery*; D011446:Prospective Studies; D015203:Reproducibility of Results; D013524:Surgical Flaps / Q000473:pathology*; D041623:Tomography, Optical Coherence