title: Deceased donor kidney transplantation in elderly patients: is there a difference in outcomes?
abstract: BACKGROUND
  There is a paucity of data on long-term outcomes of older kidney recipients. Our aim was to compare the early and long-term outcomes of deceased donor kidney transplantation in patients aged >or=60 years with outcomes in younger recipients.
  
  
  METHODS
  From 1998 to 2005, we performed 271 deceased donor kidney transplants. There were 76 recipients (28.1%) >60 years old. Older candidates were carefully selected based on their physiologic, cardiac, and performance status. Demographic data, including clinical characteristics, early complications, mortality, and patient and graft survival rates, were collected and analyzed.
  
  
  RESULTS
  Older patients had comparable perioperative mortality and morbidity, incidence of delayed graft function (DGF), length of stay, and readmissions compared with younger patients. The rates of acute rejection and major infections were also comparable between the 2 study groups. Among older recipients, 25/76 (32.1%) patients received extended criteria donor kidneys compared with only 35/195 (17.9%) of younger patients (P < .001). Nevertheless, equivalent 1-, 3-, and 5-year allograft survival rates were observed in elderly and young patients; 91.5% versus, 92.5%, 78.5% versus 81.9%, and 75.6% versus 78.5%, respectively. Overall patient survival was also comparable in both groups.
  
  
  CONCLUSIONS
  Kidney transplantation in appropriately selected elderly recipients provides equivalent outcomes compared with those observed in younger patients. These observations support the notion that older recipients should not lose access to deceased donor kidney transplantation in the effort to achieve a perceived gain in social utility.
authors.affiliation: Department of Surgery, Transplantation Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
authors.forename: R F
authors.initials: RF
authors.lastname: Saidi
authors.forename: P T
authors.initials: PT
authors.lastname: Kennealey
authors.forename: N
authors.initials: N
authors.lastname: Elias
authors.forename: T
authors.initials: T
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Hertl
authors.forename: M
authors.initials: M
authors.lastname: Farrell
authors.forename: N
authors.initials: N
authors.lastname: Goes
authors.forename: C
authors.initials: C
authors.lastname: Hartono
authors.forename: N
authors.initials: N
authors.lastname: Tolkoff-Rubin
authors.forename: A B
authors.initials: AB
authors.lastname: Cosimi
authors.forename: D S C
authors.initials: DS
authors.lastname: Ko
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D003404:Creatinine / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D016030:Kidney Transplantation / Q000401:mortality / Q000502:physiology* / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data; D016896:Treatment Outcome
chemical_list: D003404:Creatinine