Molecular mechanisms of testosterone action in spermatogenesis.
Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cells of the testis are discussed in relation to testosterone-regulated processes that are required for spermatogenesis.
Walker
William H
WH
Department of Cell Biology and Physiology and the Center for Research in Reproductive Physiology, Magee Women's Research Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States. walkerw@pitt.edu
D000818:Animals; D006801:Humans; D008297:Male; D012708:Sertoli Cells / Q000378:metabolism*; D013091:Spermatogenesis / Q000502:physiology*; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000502:physiology*
D013739:Testosterone