title: The Generation R Study: design and cohort update until the age of 4 years.
abstract: The Generation R Study is a population-based prospective cohort study from fetal life until young adulthood. The study is designed to identify early environmental and genetic causes of normal and abnormal growth, development and health from fetal life until young adulthood. The study focuses on four primary areas of research: (1) growth and physical development; (2) behavioural and cognitive development; (3) diseases in childhood; and (4) health and healthcare for pregnant women and children. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Of all eligible children at birth, 61% participate in the study. In addition, more detailed assessments are conducted in a subgroup of 1,232 pregnant women and their children. Data collection in the prenatal phase and postnatal phase until the age of 4 years includes questionnaires, detailed physical and ultrasound examinations, behavioural observations and biological samples. This paper gives an update of the study design and cohort profile until the children's age of 4 years. Eventually, results forthcoming from the Generation R Study have to contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
authors.affiliation: The Generation R Study Group (AE006), Erasmus Medical Center, Rotterdam, The Netherlands. v.jaddoe@erasmusmc.nl
authors.forename: Vincent W V
authors.initials: VW
authors.lastname: Jaddoe
authors.forename: Cornelia M
authors.initials: CM
authors.lastname: van Duijn
authors.forename: Albert J
authors.initials: AJ
authors.lastname: van der Heijden
authors.forename: Johan P
authors.initials: JP
authors.lastname: Mackenbach
authors.forename: Henriëtte A
authors.initials: HA
authors.lastname: Moll
authors.forename: Eric A P
authors.initials: EA
authors.lastname: Steegers
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.forename: Andre G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Frank C
authors.initials: FC
authors.lastname: Verhulst
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
mesh_terms: D002652:Child Behavior / Q000502:physiology*; D002657:Child Development / Q000502:physiology*; D002675:Child, Preschool; D003625:Data Collection / Q000379:methods*; D005191:Family Characteristics; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008427:Maternal Health Services; D009426:Netherlands / Q000453:epidemiology; D010808:Physical Examination; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D011295:Prenatal Care; D011446:Prospective Studies; D012107:Research Design; D012307:Risk Factors; D011795:Surveys and Questionnaires