title: Contribution of polymorphism in codon 72 of TP53 gene to laryngeal cancer in Polish patients.
abstract: The amino acid substitution Arg72Pro in the TP53 protein has an impact on the biochemical and biological activity of this protein, and is associated with several types of cancers. However, the Arg72Pro polymorphism exhibits inconsistent contribution as a risk factor in various cancer types. Therefore, using PCR-RFLPs, we investigated the distribution of Arg72Pro genotypes and alleles in patients with laryngeal cancer (n=123) and controls (n=300) in Poland. We observed that patients with the Pro/Pro and Arg/Pro TP53 genotypes displayed a 1.755-fold increased risk of laryngeal cancer (95% CI=1.149-2.680, P=0.0099). However, we did not find a significant increase in laryngeal cancer risk for the homozygous Pro/Pro TP53 genotype OR=2.093 (95% CI=1.046-4.192, P=0.0530). This result suggests that the TP53Pro variant may contribute to the risk of laryngeal cancer development in Polish patients.
authors.affiliation: Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Swiecickiego Street, Poznań, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zemleduch
authors.forename: Margarita
authors.initials: M
authors.lastname: Lianeri
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Rydzanicz
authors.forename: Marzena
authors.initials: M
authors.lastname: Gajecka
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
authors.forename: Paweł P
authors.initials: PP
authors.lastname: Jagodziński
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D016022:Case-Control Studies; D003062:Codon / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012306:Risk; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D003062:Codon; D016159:Tumor Suppressor Protein p53