[Research development of the induced animal model of osteoarthritis].
Osteoarthritis (OA) is a retrogressive arthrosis of which incidence rate increased obviously with the age. Accompany with the aging of the population, the incidence of this disease appeares an upward trend significantly. The etiology and pathogenesis of AO is not very clear at present, so it's important to establish animal models for discussing the pathogenesis of AO and searching reasonable ways to diagnose and treat. The induced animal model is used more commonly, it includes non-operation ways and operation ways, the former includes drug injection, joint immobilization, transarticular impact, etc.; the latter includes destroy the stability of joint, change the stress of joint, snick on condylofemur etc. This article makes a brief review on those questions, looks forward to providing some reference on choosing OA animal model correctly and reasonably.
Shen
Yan
Y
Zhejiang University of Traditional Chinese Medicine, Hangzhou 310053, Zhejiang, China. louissy@163.com
Jin
Hong-ting
HT
Tong
Pei-jian
PJ
Xiao
Lu-wei
LW
D000818:Animals; D035843:Biomedical Research; D004195:Disease Models, Animal; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology / Q000601:surgery