title: [A clinical study on splanchnic hemodynamic changes after orthotopic liver transplantation for patients with portal hypertension].
abstract: OBJECTIVE
  To study the regularity of splanchnic hemodynamic changes after orthotopic liver transplantation (OLT) for patients with portal hypertension. At the same time, effect of such changes on splenomegaly, hypersplenism, collateral circulation and the postoperative liver function was discussed.
  
  
  METHODS
  Between June 2002 and October 2005, 173 liver transplantations were performed. In 38 patients with portal hypertension undergoing OLT, the following parameters were measured before surgery and subsequently at 1, 3, 5, 7 days, 1, 6 months and 1, 2, 3 years after operation by using Color Doppler sonography: portal blood flow mean velocity (PBV), portal blood flow volume (PBF), hepatic artery resistance indexes (HA-RI) and spleen size. The same parameters were measured in 8 patients with acute liver failure and 20 healthy controls. Meanwhile to observe liver function and varicose vein of esophagus.
  
  
  RESULTS
  In cirrhotics, PBV and PBF increased immediately after transplantation [from (13.7 +/- 4.2) cm/s to (58.4 +/- 25.2) cm/s and from (958 +/- 445) ml/min to (3024 +/- 1207) ml/min respectively, P < 0.05]. HA-RI also augmented [from (0.65 +/- 0.11) to (0.74 +/- 0.12), P < 0.05]. PBV returned to normal values after 6 months, PBF returned to normal value after 2 years. Spleen size decreased significantly, but splenomegaly persisted after 3 years. In addition the esophagogastric varix ameliorated significantly.
  
  
  CONCLUSIONS
  Abnormal splanchnic hemodynamic changes for patients with portal hypertension still will long-term exist after OLT, but does not effect recovery of hypersplenism, esophagogastric varix and liver function.
authors.affiliation: Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China.
authors.forename: Shui-ming
authors.initials: SM
authors.lastname: Jiang
authors.forename: Guang-wen
authors.initials: GW
authors.lastname: Zhou
authors.forename: Chuan
authors.initials: C
authors.lastname: Shen
authors.forename: Jie-qi
authors.initials: JQ
authors.lastname: Yan
authors.forename: Liang
authors.initials: L
authors.lastname: Wan
authors.forename: Qin-yu
authors.initials: QY
authors.lastname: Li
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Yang
authors.forename: Bai-yong
authors.initials: BY
authors.lastname: Shen
authors.forename: Hao
authors.initials: H
authors.lastname: Chen
authors.forename: Cheng-hong
authors.initials: CH
authors.lastname: Peng
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics; D006499:Hepatic Artery / Q000503:physiopathology; D006801:Humans; D006975:Hypertension, Portal / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D007432:Intraoperative Period; D008099:Liver / Q000503:physiopathology; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000503:physiopathology; D013152:Splanchnic Circulation / Q000502:physiology*; D013154:Spleen / Q000473:pathology