title: [Drug rash with eosinophilia and systemic symptoms (DRESS syndrome)].
abstract: Adverse cutaneous reactions to drugs are frequent, affecting from 2% to 3% of all hospitalized patients. But only about 2% of these cutaneous reactions are severe and seldom are fatal. The term drug hypersensitivity syndrome refers to a specific severe drug reaction, including skin rash, fever, lymph node enlargement, and single or multiple organ involvement. The cutaneous rash is usually morbilliform. The drugs associated with the syndrome are: anticonvulsants, ACE inhibitors, Beta-blockers, allopurinol and sulphonamides. The differential diagnosis includes maculopapular rash, exfoliative dermatitis, acute generalized exanthematous pustulosis and Sézary syndrome. The interval between the starting of drug therapy and the onset of cutaneous reactions may be at least one month, and therefore the implication of the drug in the aetiology may be subdiagnosed.
authors.affiliation: Serviço de Dermatologia, Hospital Geral de Santo António, Porto.
authors.forename: Inês
authors.initials: I
authors.lastname: Lobo
authors.forename: Márcia
authors.initials: M
authors.lastname: Ferreira
authors.forename: Glória
authors.initials: G
authors.lastname: Velho
authors.forename: Madalena
authors.initials: M
authors.lastname: Sanches
authors.forename: Manuela
authors.initials: M
authors.lastname: Selores
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced*; D006801:Humans