[The influence of anisodamine on cardiopulmonary resuscitation in rat].
OBJECTIVE
To evaluate the influence of anisodamine (Ani) on restoration of spontaneous circulation (ROSC) and cardiopulmonary resuscitation (CPR) rate in a randomized, blinded experimental study so as to explore a new treatment for CPR.


METHODS
Forty-five Sprague-Dawley (SD) rats were randomized to three groups: control group (0.9% normal saline), epinephrine (Epi) group and Epi plus Ani group (combined group), 15 rats in each group. Ventricular fibrillation (VF) or asystole was induced by transoesophageal alternating current stimulation. A blinded drug administration and mechanical chest compression were used in this study (Epi 200 microg/kg, Ani 10 mg/kg). ROSC rate and resuscitation rate were compared among these groups.


RESULTS
Combined group had higher ROSC rate(93.3% vs. 46.7%), resuscitation rate (80.0% vs.33.3%) and survival rate within 3 hours (83.3% vs.20.0%) compared with Epi group (all P<0.05). ROSC occurred only in one rat of control group. Mean arterial pressure (MAP) at the beginning of ROSC in Epi group was higher compared with combined group (P<0.05). After ROSC, MAP decreased in both drug groups, especially after 5 minutes of ROSC, and MAP in Epi group was lower than that of combined group. There was difference between the two groups till 30 minutes after ROSC (all P<0.05) .


CONCLUSIONS
Administration of Epi plus Ani at the beginning of treatment for cardiac arrest could improve ROSC rate and resuscitation rate.
Sun
Jing
J
Emergency Department, General Hospital of PLA, Beijing 100853, China.
Meng
Fan-Shan
FS
Chen
Wei
W
Liu
Xiu-Hua
XH
Shen
Hong
H
D000818:Animals; D016887:Cardiopulmonary Resuscitation; D004195:Disease Models, Animal; D004837:Epinephrine / Q000627:therapeutic use; D005260:Female; D006323:Heart Arrest / Q000628:therapy*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*
D012991:Solanaceous Alkaloids; C003922:anisodamine; D004837:Epinephrine