title: Yeast hydrolysate induces longitudinal bone growth and growth hormone release in rats.
abstract: This study investigated the growth promoting effects of yeast extract (YH) fed to Sprague-Dawley male rats (3 weeks old) for 4 weeks. The negative (N)-control and positive (P)-control groups were given a daily oral administration of saline and foremilk (1 g/kg of BW), respectively, and the YH-1 and YH-2 groups were given daily administrations of YH (0.5 and 1 g/kg of BW, respectively). After 4 weeks, the YH-1, YH-2 and P-control groups showed significant differences in the body weight gain compared with the N-control group (p < 0.05). The YH-1 and YH-2 groups also had significantly different tibial bone growths (0.47 and 0.49 mm/day, respectively) and femur bone growths (0.52 and 0.53 mm/day, respectively) compared with the N-control group (0.37 mm/day of tibial growth and 0.42 mm/day of femur growth) (p < 0.05). The YH-1 and YH-2 groups had significantly different growth plate (proximal epiphysis) height increments (0.62 and 0.56 mm, respectively) compared with the N-control group (0.17 mm) (p < 0.05). Lastly, the YH-1 and YH-2 groups presented different growth hormone (GH) levels (1.77 and 2.10 ng/mL, respectively) than the N-control group (0.82 ng/mL) (p < 0.05). YH administration increased longitudinal bone growth and GH secretion in rats. Consequently, YH may offer an improved ability to treat GH deficiency-related disorders.
authors.affiliation: Department of Radiologic Science, Korea University, Seoul, Korea.
authors.forename: Jung Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Seong-Yeong
authors.initials: SY
authors.lastname: Kim
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Jung
authors.forename: Song Hwan
authors.initials: SH
authors.lastname: Bae
authors.forename: Hyung Joo
authors.initials: HJ
authors.lastname: Suh
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001846:Bone Development / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004032:Diet; D005269:Femur / Q000187:drug effects; D013006:Growth Hormone / Q000378:metabolism*; D006132:Growth Plate / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000187:drug effects; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain; D015002:Yeast, Dried / Q000378:metabolism*
chemical_list: D014280:Triglycerides; D013006:Growth Hormone; D002784:Cholesterol