title: Dual and beneficial roles of macrophages during skeletal muscle regeneration.
abstract: Macrophages are necessary for skeletal muscle regeneration after injury. Muscle recruits inflammatory monocytes/macrophages that switch toward an anti-inflammatory profile upon phagocytosis of debris. In vitro, proinflammatory macrophages stimulate myoblast proliferation, whereas anti-inflammatory macrophages stimulate their differentiation. Thus, macrophages are involved in both phases of skeletal muscle regeneration: first, inflammation and cleansing of necrosis, and then myogenic differentiation and tissue repair.
authors.affiliation: Institut COCHIN INSERM U567 CNRS UMR8104, Paris, France. benedicte.chazaud@inserm.fr
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Chazaud
authors.forename: Madly
authors.initials: M
authors.lastname: Brigitte
authors.forename: Houda
authors.initials: H
authors.lastname: Yacoub-Youssef
authors.forename: Ludovic
authors.initials: L
authors.lastname: Arnold
authors.forename: Romain
authors.initials: R
authors.lastname: Gherardi
authors.forename: Corinne
authors.initials: C
authors.lastname: Sonnet
authors.forename: Peggy
authors.initials: P
authors.lastname: Lafuste
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chretien
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology*; D009000:Monocytes / Q000502:physiology; D018482:Muscle, Skeletal / Q000293:injuries / Q000502:physiology*; D032446:Myoblasts / Q000166:cytology; D010641:Phenotype; D012038:Regeneration