The inhibitory effect on aldose reductase by an extract of Ganoderma lucidum.
The human aldose reductase inhibitory effects of the methanol extracts of 17 medicinal and edible mushrooms were examined. Ganoderma lucidum showed the highest aldose reductase inhibitory activity compared with the other mushrooms. The effect of an ethanol extract of G. lucidum on the galactitol level in the eye lens was studied in a galactosemic rat model in vivo. This mushroom significantly decreased the galactitol accumulation.
Fatmawati
Sri
S
Department of Forest and Forest Product Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Kurashiki
Kenji
K
Takeno
Sayaka
S
Kim
Yong-Ung
YU
Shimizu
Kuniyoshi
K
Sato
Masao
M
Imaizumi
Katsumi
K
Takahashi
Kaori
K
Kamiya
Shinji
S
Kaneko
Shuhei
S
Kondo
Ryuichiro
R
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D004376:Galactitol / Q000378:metabolism; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D020940:Reishi / Q000737:chemistry*
D004791:Enzyme Inhibitors; D004376:Galactitol; D000449:Aldehyde Reductase