title: Addition of ethynylferrocene to transition-metal complexes containing a chelating 1,2-dicarba-closo-dodecaborane-1,2-dichalcogenolate ligand--in vitro cooperativity of a ruthenium compound on cellular uptake of an anticancer drug.
abstract: The addition reactions of the 16e half-sandwich complexes (p-cymene)M(S2C2B10H10) (, M=Ru; , M=Os) and Cp*Ir(E2C2B10H10) (, E=S; , E=Se) with ethynylferrocene lead selectively to the 18e complexes (p-cymene)Ru(S2C2B10H9)(H2CCFc) (Fc=ferrocenyl) (), (p-cymene)Os(S2C2B10H9)(H2CCFc) (), Cp*Ir(S2C2B10H9)(H2CCFc) () and Cp*Ir(Se2C2B10H9)(H2CCFc) (), in which the alkyne is regio- and stereoselectively inserted into one of the M-E bonds that may further lead to metal-induced B-H activation, hydrogen atom transfer from the carborane via the metal center to the inserted alkyne, and the generation of a M-B bond. In all complexes the S-eta2-(Fc)C-C and C-B(M) moieties occupy a cisoid position. The four new complexes are characterized by IR, MS, NMR spectroscopy and microanalysis, and the X-ray structural analysis of is performed. was observed to promote the uptake of anticancer drug daunorubicin in drug-resistant leukemia K562 cells.
authors.affiliation: State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210093, China.
authors.forename: De-Hong
authors.initials: DH
authors.lastname: Wu
authors.forename: Chun-Hui
authors.initials: CH
authors.lastname: Wu
authors.forename: Yi-Zhi
authors.initials: YZ
authors.lastname: Li
authors.forename: Da-Dong
authors.initials: DD
authors.lastname: Guo
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Yan
mesh_terms: D000277:Adjuvants, Pharmaceutic / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002614:Chelating Agents / Q000737:chemistry; D018360:Crystallography, X-Ray; D003630:Daunorubicin / Q000737:chemistry / Q000494:pharmacology*; D004563:Electrochemistry; D005296:Ferrous Compounds / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D018613:Microscopy, Confocal; D008956:Models, Chemical; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D012428:Ruthenium / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000277:Adjuvants, Pharmaceutic; D000970:Antineoplastic Agents; D002614:Chelating Agents; D005296:Ferrous Compounds; D008024:Ligands; D009942:Organometallic Compounds; C480779:ethynylferrocene; D012428:Ruthenium; D003630:Daunorubicin