title: Multi-pinhole collimator design for small-object imaging with SiliSPECT: a high-resolution SPECT.
abstract: We have designed a multi-pinhole collimator for a dual-headed, stationary SPECT system that incorporates high-resolution silicon double-sided strip detectors. The compact camera design of our system enables imaging at source-collimator distances between 20 and 30 mm. Our analytical calculations show that using knife-edge pinholes with small-opening angles or cylindrically shaped pinholes in a focused, multi-pinhole configuration in combination with this camera geometry can generate narrow sensitivity profiles across the field of view that can be useful for imaging small objects at high sensitivity and resolution. The current prototype system uses two collimators each containing 127 cylindrically shaped pinholes that are focused toward a target volume. Our goal is imaging objects such as a mouse brain, which could find potential applications in molecular imaging.
authors.affiliation: Vanderbilt University Institute of Imaging Science, Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN, USA. Sepideh.shokouhi@vanderbilt.edu
authors.forename: S
authors.initials: S
authors.lastname: Shokouhi
authors.forename: S D
authors.initials: SD
authors.lastname: Metzler
authors.forename: D W
authors.initials: DW
authors.lastname: Wilson
authors.forename: T E
authors.initials: TE
authors.lastname: Peterson
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001921:Brain / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D004867:Equipment Design; D021621:Imaging, Three-Dimensional; D051379:Mice; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D012542:Scattering, Radiation; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation* / Q000379:methods / Q000706:statistics & numerical data