Integrative action of receptor mosaics: relevance of receptor topology and allosteric modulators.
After a definition of the receptor mosaic (RM, high order heteromer or homomer) concept, this study analyzes some relevant theoretical aspects related to receptor-receptor interactions (RRIs). In particular, the possible influence of the plasma membrane microdomain on RM integrative functions are discussed. Furthermore, a possible mathematical approach may identify the RM topologies [i.e., the spatial arrangements the receptors (tesserae of the mosaic) can assume within the RM assembly]. Finally, data are presented on homocysteine possible biasing action on the well-characterized heterodimer/receptor mosaic formed by adenosine A2A and dopamine D2 receptors. We discuss how these findings can lead to a new possible approach for developing drugs for the treatment of certain neuropsychiatric disorders.
Francesco
Agnati Luigi
AL
Department of Biomedical Sciences, University of Modena and Reggio Emilia and IRCCS Lido, Venezia, Italy. agnatiluigi@tin.it
Diego
Guidolin
G
Susanna
Genedani
G
Giuseppina
Leo
L
Amina
Woods S
WS
Sergi
Ferrè
F
Rafael
Franco
F
Kjell
Fuxe
F
D000494:Allosteric Regulation; D000818:Animals; D002462:Cell Membrane / Q000502:physiology*; D006801:Humans; D021962:Membrane Microdomains / Q000378:metabolism*; D008962:Models, Theoretical; D020239:Receptor Cross-Talk / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000378:metabolism*
D011956:Receptors, Cell Surface