title: Type 1 Diabetes TrialNet--an international collaborative clinical trials network.
abstract: Type 1 Diabetes TrialNet is an international consortium of clinical research centers aimed at the prevention or delay of type 1 diabetes (T1D). The fundamental goal of TrialNet is to counter the T1D disease process by immune modulation and/or enhancement of beta cell proliferation and regeneration. To achieve this goal, TrialNet researchers are working to better understand the natural history of the disease, to identify persons at risk, and to clinically evaluate novel therapies that balance potential risks and benefits. The particular focus is on studies of preventive measures. In addition, TrialNet evaluates therapies in individuals with newly diagnosed T1D with preserved beta cell function to help determine the risk/benefit profile and gain an initial assessment of potential efficacy in preservation of beta cell function, so that promising agents can be studied in prevention trials. In addition, TrialNet evaluates methodologies that enhance the conduct of its clinical trials, which includes tests of outcome assessment methodology, the evaluation of surrogate markers, and mechanistic studies laying the foundation for future clinical trials.
authors.affiliation: Diabetes Research Institute, Miami, Florida 33101-6960, USA. jskyler@miami.edu
authors.forename: Jay S
authors.initials: JS
authors.lastname: Skyler
authors.forename: Carla J
authors.initials: CJ
authors.lastname: Greenbaum
authors.forename: John M
authors.initials: JM
authors.lastname: Lachin
authors.forename: Ellen
authors.initials: E
authors.lastname: Leschek
authors.forename: Lisa
authors.initials: L
authors.lastname: Rafkin-Mervis
authors.forename: Peter
authors.initials: P
authors.lastname: Savage
authors.forename: Lisa
authors.initials: L
authors.lastname: Spain
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D016208:Databases, Factual; D003922:Diabetes Mellitus, Type 1 / Q000517:prevention & control* / Q000628:therapy*; D018450:Disease Progression; D006295:Health Resources / Q000600:supply & distribution; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007391:International Cooperation; D054586:National Institute of Diabetes and Digestive and Kidney Diseases (U.S.); D014481:United States
chemical_list: D007004:Hypoglycemic Agents