Effective treatment for advanced hepatocellular carcinoma with portal venous invasion using a combination therapy of intra-arterial 5-fluorouracil and subcutaneous pegylated-interferon-alpha-2b.
Hepatocellular carcinoma with portal venous invasion has a poor prognosis. We report a case treated successfully by intra-arterial 5-fluorouracil with systemic pegylated-interferon-alpha-2b instead of conventional interferon-alpha. A 66-year-old man was admitted to our hospital, and diagnosed with hepatocellular carcinoma with portal venous invasion. Following informed consent, he was treated with eight week cycles of combination chemotherapy using intra-arterial 5-fluorouracil (500 mg/body/day i.a., days 1-5, 8-12 continuously) and pegylated-interferon-alpha-2b (100 microg body s.c., days 1, 8). No significant side effects were observed during his therapy. After 4 cycles, computed tomography scan revealed a partial response of tumor reduction. This is the first report of advanced hepatocellular carcinoma effectively treated using subcutaneous pegylated-interferon-alpha-2b with intra-arterial 5-fluorouracil. While the conventional therapy of interferon-alpha with 5-fluorouracil has significant side effects, no significant side effects were observed in our case. The use of subcutaneous pegylated-interferon-alpha-2b combined with intraarterial 5-fluorouracil, may improve patients' quality of life.
Mawatari
Hironori
H
Gastroenterology Division, Yokohama City University School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Kirikoshi
Hiroyuki
H
Yoneda
Masato
M
Higurashi
Takuma
T
Fujita
Koji
K
Saito
Satoru
S
Inamori
Masahiko
M
Takahashi
Hirokazu
H
Abe
Yasunobu
Y
Kubota
Kensuke
K
Nakajima
Atsushi
A
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000473:pathology; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D011092:Polyethylene Glycols; D011169:Portal Vein / Q000473:pathology*; D011788:Quality of Life; D011994:Recombinant Proteins
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C417083:peginterferon alfa-2b; D005472:Fluorouracil