Influence of metals on the activity of a bradykinin-destroying enzyme kininase.
Kininase prepared from guinea-pig serum was inhibited by cysteine at pH 7.4 to 7.6. A similar effect was found with edetic acid. The enzyme blocked by edetic acid was reactivated immediately by addition of Mn(++), Co(++) and Zn(++). These findings indicate that kininase is a metal-activated enzyme.
Aarsen
P N
PN
Kemp
A
A