Expression of S100A4, E-cadherin, alpha- and beta-catenin in gastric adenocarcinoma.
OBJECTIVE
This investigation aimed to elucidate the expression patterns of S100A4 and adhesion molecules in gastric carcinoma and to estimate their correlation with clinicopathologic parameters.


METHODS
The expression of S100A4, E-cadherin, alpha- and beta-catenin was studied in 251 gastric carcinoma specimens through immunohistochemical staining.


RESULTS
The positive expression of S100A4 was significantly associated with advanced gastric cancer, higher pTNM stage, and poorer survival rates, especially when present in nuclear staining. The reduced expression of adhesion molecules was significantly associated with diffuse type of gastric cancer. The reduced expression of beta-catenin was significantly associated with lymph node metastasis, especially in early gastric cancer. The coexpression status of S100A4-positive and reduced beta-catenin was significantly associated with larger tumor size, advanced tumor depth, and higher pTNM stage.


CONCLUSIONS
S100A4 and adhesion molecule expression may be a useful prognostic marker for individual gastric cancer patients.
Yoon
Chan-Seok
CS
Department of Surgery, Cheil General Hospital & Women's Healthcare Center, Kwandong University College of Medicine, Korea.
Hyung
Woo Jin
WJ
Lee
Ju-Han
JH
Chae
Yang-Seok
YS
Won
Nam Hee
NH
Yeom
Bum-Woo
BW
Choi
Jong Sang
JS
D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins / Q000032:analysis*; D013274:Stomach Neoplasms / Q000737:chemistry* / Q000473:pathology; D051178:alpha Catenin / Q000032:analysis*; D051176:beta Catenin / Q000032:analysis*
D015820:Cadherins; D000071999:S100 Calcium-Binding Protein A4; D009418:S100 Proteins; D051178:alpha Catenin; D051176:beta Catenin; C077591:S100A4 protein, human