title: Small molecule mimics of hydrogenases: hydrides and redox.
abstract: This tutorial review is aimed at chemical scientists interested in understanding and exploiting the remarkable catalytic behavior of the hydrogenases. The key structural features are analyzed for the active sites of the two most important hydrogenases. Reactivity is emphasized, focusing on mechanism and catalysis. Through this analysis, gaps are identified in the synthesis of functional replicas of these fascinating and potentially useful enzymes.
authors.affiliation: UMR CNRS 6521, Université de Bretagne Occidentale, CS 93837, 29238 Brest cedex 3, France. fgloaguen@gmail.com
authors.forename: Frédéric
authors.initials: F
authors.lastname: Gloaguen
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Rauchfuss
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000378:metabolism; D055162:Biocatalysis; D032701:Biomimetics / Q000639:trends; D020134:Catalytic Domain; D003013:Clostridium / Q000201:enzymology; D045285:Desulfovibrio desulfuricans / Q000201:enzymology; D005290:Ferric Compounds / Q000737:chemistry* / Q000378:metabolism; D006859:Hydrogen / Q000378:metabolism*; D006864:Hydrogenase / Q000737:chemistry* / Q000378:metabolism; D007501:Iron / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D054852:Small Molecule Libraries; D013438:Sulfhydryl Compounds / Q000737:chemistry* / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D005290:Ferric Compounds; D054852:Small Molecule Libraries; D013438:Sulfhydryl Compounds; C002007:dithiol-iron(III)-sulfide complex; D006859:Hydrogen; D007501:Iron; D006864:Hydrogenase