Thyrotoxic hypokalemic periodic paralysis: a life-threatening syndrome.
Hypokalemic periodic paralysis is a rare life-threatening syndrome, potentially reversible when detected at an early stage. Hypokalemia may also occur in other conditions characterized by muscle weakness. Acute myopathy associated with thyrotoxicosis has been described in Asian populations, although it seldom affects Caucasians or African-Americans. It can be difficult to recognize in western populations. Acute recurrent episodes of flaccid paralysis, symmetrically affecting the proximal muscles of the lower limbs, either following strenuous physical activity or carbohydrate overindulgence, is the usual presentation. Hypokalemia seems to result from transcellular shifts of potassium rather than losses. A case of thyrotoxic hypokalemic periodic paralysis occurring in a young Caucasian male diagnosed with Graves' disease is reported.
Antonello
Ivan Carlos Ferreira
IC
Division of Nephrology, Department of Internal Medicine, Medical School, Catholic Pontifical University of Rio Grande do Sul, Brazil.
Antonello
Vicente Sperb
VS
de Los Santos
Carlos Abaeté
CA
de Almeida
Nelsoni
N
d'Avila
Domingos Otávio Lorenzoni
DO
D013956:Antithyroid Agents / Q000627:therapeutic use; D006801:Humans; D007008:Hypokalemia / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D018908:Muscle Weakness / Q000209:etiology; D010243:Paralysis / Q000209:etiology*; D011441:Propylthiouracil / Q000627:therapeutic use; D013971:Thyrotoxicosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D055815:Young Adult
D013956:Antithyroid Agents; D011441:Propylthiouracil