[Apoptosis induced by granzyme B].
Results of biochemical studies of apoptosis reactions induced by granzyme B are considered and summarized. Special attention is paid to the reactions of procaspase activation and limited proteolysis of apoptotic targets. Found values of kinetic constants of granzyme B-mediated enzymatic reactions are listed.
Sintsov
A V
AV
Center for Theoretical Problems of Physicochemical Pharmacology, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 119991 Russia.
Kovalenko
E I
EI
Khanin
M A
MA
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000737:chemistry / Q000378:metabolism*; D004792:Enzyme Precursors / Q000737:chemistry / Q000378:metabolism*; D053804:Granzymes / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007700:Kinetics
D004792:Enzyme Precursors; D053804:Granzymes; D020169:Caspases