Targeted delivery of activatable fluorescent pro-apoptotic peptide into live cells.
A new fluorescence imaging system is used to visualize the specific cytotoxic biomolecule delivery within living biological samples by means of FRET quenching.
Foillard
Stéphanie
S
Department de Chimie Moléculaire, UMR CNRS/UJF 5250ICMG FR 2607, 38041 Grenoble cedex 9, France.
Sancey
Lucie
L
Coll
Jean-Luc
JL
Boturyn
Didier
D
Dumy
Pascal
P
D017209:Apoptosis; D002232:Carbocyanines / Q000008:administration & dosage / Q000737:chemistry; D002478:Cells, Cultured; D004337:Drug Carriers / Q000737:chemistry*; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000737:chemistry*; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides / Q000008:administration & dosage* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry*
D002232:Carbocyanines; D004337:Drug Carriers; D005456:Fluorescent Dyes; D007211:Indoles; D036341:Intercellular Signaling Peptides and Proteins; C535058:KLA peptide; D010455:Peptides; D010456:Peptides, Cyclic; C085321:cyanine dye 5