Non-life-threatening leukopenia in a renal transplant recipient with acute overdose of mycophenolate mofetil.
Mycophenolate mofetil (MMF) is increasingly used as an immunosuppressant for organ transplantation and for treatment of autoimmune diseases. As yet, the experience with acute overdose of MMF in humans is limited. Herein we have reported a 40-year-old female kidney recipient with moderate leukopenia and lack of gastrointestinal toxicity following ingestion of 25 g MMF, which was confirmed by serum drug levels. We treated the patient with charcoal decontamination and oral cholestyramine. She recovered completely without sequelae.
Wu
S-W
SW
Division of Nephrology, Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan.
Chang
H-R
HR
Lai
Y-R
YR
Lian
J-D
JD
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001569:Benzodiazepines / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D003975:Diazepam / Q000031:analogs & derivatives / Q000627:therapeutic use; D003987:Dibenzothiazepines / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000633:toxicity; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology*; D007970:Leukopenia / Q000139:chemically induced*; D009173:Mycophenolic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D000069348:Quetiapine Fumarate; D006435:Renal Dialysis; D014635:Valproic Acid / Q000627:therapeutic use
D000928:Antidepressive Agents; D003987:Dibenzothiazepines; D007166:Immunosuppressive Agents; D002792:Cholestyramine Resin; D001569:Benzodiazepines; D002606:Charcoal; D000069348:Quetiapine Fumarate; D014635:Valproic Acid; C006107:fludiazepam; D009173:Mycophenolic Acid; D003975:Diazepam