title: The distribution of tritium-labelled prostaglandin E(1) injected in amounts sufficient to produce central nervous effects in cats and chicks.
abstract: 1. After injection of tritiated prostaglandin E(1) into the lateral cerebral ventricle, the carotid and vertebral arteries and the aorta in cats, only a small proportion of the radioactivity was recovered from the central nervous system.2. Similar results were obtained when the prostaglandin was given intra-venously and intra-arterially to chicks.3. The results of this study confirm work in other species (Hansson & Samuelsson, 1965; Samuelsson, 1964, 1965) and suggest that prostaglandin E(1) exerts its central pharmacological actions in small concentrations.
authors.forename: S W
authors.initials: SW
authors.lastname: Holmes
authors.forename: E W
authors.initials: EW
authors.lastname: Horton