[A case of combined hepatocellular and cholangiocarcinoma showing tumor growth and invasion to the diaphragm during interferon-alpha and 5-fluorouracil combined intra-arterial chemotherapy].
We report a case of combined hepatocellular and cholangiocarcinoma showing tumor growth and invasion to the diaphragm during interferon-alpha (IFN-alpha) and 5-fluorouracil (5-FU) combined intra-arterial chemotherapy. A 63-year-old female was in hospital for treatment of hepatic tumor in left lobe with portal venous tumor thrombus. She was treated by IFN-alpha/5-FU chemotherapy, and the tumor was significantly reduced. For 28 months, the tumor was successfully treated by IFN-alpha/5-FU chemotherapy. But, thereafter the abdominal computed tomography showed the tumor re-growth and invasion to the diaphragm. Then the patient underwent the tumor resection. The histological findings were consistent with combined hepatocellular and cholangiocarcinoma. Immunohistological examination revealed a heterogeneous expression of IFN-alpha receptor 2. This case suggested that the growth of cancer cells without sensitivity to IFN-alpha/5-FU chemotherapy and the blood supply via the diaphragm led the relapse of IFN-alpha/5-FU chemotherapy.
Noda
Takehiro
T
Dept. of Surgery, Graduate School of Medicine, Osaka University.
Nagano
Hiroaki
H
Marubashi
Shigeru
S
Kobayashi
Shogo
S
Takeda
Yutaka
Y
Murakami
Masahiro
M
Tomimaru
Yoshito
Y
Dono
Keizo
K
Umeshita
Koji
K
Nakayama
Mika
M
Shima
Toshihide
T
Wakasa
Kenichi
K
Monden
Morito
M
Doki
Yuichiro
Y
Mori
Masaki
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D018281:Cholangiocarcinoma / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003964:Diaphragm / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007261:Infusions, Intra-Arterial; D016898:Interferon-alpha / Q000008:administration & dosage / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000556:secondary*; D009361:Neoplasm Invasiveness / Q000473:pathology; D014057:Tomography, X-Ray Computed; D000509:alpha-Fetoproteins / Q000378:metabolism
D016898:Interferon-alpha; D000509:alpha-Fetoproteins; D005472:Fluorouracil