Immune response of Theileria sp.-infected sheep to recombinant Theileria proteins.
Sheep and goats in northwest China suffer from theileriosis from infection with Theileria sp. (China), resulting in large economic losses. To investigate the immune response to infection with Theileria sp. (China), parameters of cellular and humoral immunity of experimentally infected sheep against two recombinantly expressed Theileria proteins were investigated. The in vitro proliferative response of blood mononuclear cells to a recombinant T. annulata membrane protein and a recombinant Theileria sp. (China) homologue to T. annulata surface protein, both putative membrane proteins, was significantly elevated and significant amounts of specific immunoglobulins were produced against both.
Seitzer
Ulrike
U
Division of Veterinary Infection Biology and Immunology, Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany.
Liu
Zhijie
Z
Yin
Hong
H
Beyer
Doreen
D
Kullmann
Birgit
B
Miranda
Joana
J
Ahmed
Jabbar S
JS
D000818:Animals; D000913:Antibodies, Protozoan / Q000096:biosynthesis / Q000097:blood; D015800:Protozoan Proteins / Q000276:immunology*; D011994:Recombinant Proteins / Q000276:immunology; D012756:Sheep / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology*
D000913:Antibodies, Protozoan; D015800:Protozoan Proteins; D011994:Recombinant Proteins