title: [Therapeutic effect of Tripterygium wilfordii multiglycosides on proteinuria in kidney transplant recipients].
abstract: OBJECTIVE
  To study the effect of multiglycosides of Tripterygium wilfordii (MTW) for treatment of proteinuria in kidney transplant recipients.
  
  
  METHODS
  Forty-five kidney transplant recipients with proternuria were randomized into 3 groups (n=15) and received full daily dose (1 mg/kg) MTW, half dose (0.5 mg/kg) MTW or no MTW (control) in addition to immunosuppressant therapy. The 24-hour urinary protein (24 h Upro), blood urea nitrogen (BUN), serum creatinine (Scr), dose of ciclosporin and the adverse effects of MTW were recorded.
  
  
  RESULTS
  MTW at both the full dose and half dose significantly reduced the 24 h Upro as compared to exclusive immunosuppressant therapy (P<0.05). The therapeutic dose of ciclosporin in patients with full and half dose of MTW was significantly lower than that in the control group (P<0.05), and the patients receiving full dose MTW showed greater adverse effects than those having half dose MTW (P<0.05).
  
  
  CONCLUSIONS
  MTW can significantly ameliorate proteinuria, reduce the therapeutic dose of ciclosporin and protect the renal function in kidney transplant recipients. While producing similar therapeutic effect to routine full dose, long-term use of half dose MTW may reduce the adverse effect associated with MTW.
authors.affiliation: Department of Nephropathy, Hainan Provincial People's Hospital, Haikou 570311, China. h13976919199@126.com
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.forename: Tian-biao
authors.initials: TB
authors.lastname: Long
authors.forename: Feng
authors.initials: F
authors.lastname: Zhan
authors.forename: Chu-ying
authors.initials: CY
authors.lastname: Pan
authors.forename: Dao-jun
authors.initials: DJ
authors.lastname: Chen
authors.forename: Shu-dian
authors.initials: SD
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy* / Q000209:etiology; D029757:Tripterygium / Q000737:chemistry*; D055815:Young Adult
chemical_list: D006027:Glycosides