Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala.
Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.
Lima
Murilo M C
MM
Intituto de Química, Universidade Federal da Bahia, Campus de Ondina, Salvador (BA), Brazil.
López
Jorge A
JA
David
Jorge M
JM
Silva
Eliezer P
EP
Giulietti
Ana M
AM
de Queiroz
Luciano P
LP
David
Juceni P
JP
D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D010456:Peptides, Cyclic; D011804:Quinolines; C540623:waltherine; C502881:waltherione-A; C540622:waltherione-B; D000110:Acetylcholinesterase