title: [The relationship between dyslipemia and the polymorphism of angiotensin II type 1 receptor gene in hypertensive Kazakans of Xinjiang.].
abstract: OBJECTIVE
  To investigate the relationship between dyslipidemia and the polymorphism of angiotensin II type 1 receptor (AT(1)R) gene A1166C in hypertensive Kazakans of Xinjiang area.
  
  
  METHODS
  Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the A1166C polymorphism of AT(1)R gene of 296 hypertensive and 198 normotensive Kazakans. Biochemical parameters were measured by autochemical emalyzer.
  
  
  RESULTS
  (1) The TC and LDL-C levels are significantly higher in hypertension group than those in normotensive controls [TC: (4.91 +/- 1.19) mmol/L vs. (4.43 +/- 1.20) mmol/L; LDL-C: (3.36 +/- 1.01) mmol/L vs. (2.94 +/- 1.30) mmol/L, P < 0.001). (2) In hypertension group, TC and LDL-C are related to A1166C polymorphism of AT(1)R gene and TC and LDL-C of AC carriers are significantly higher than AA carriers (P < 0.05).
  
  
  CONCLUSIONS
  The dyslipidemia is related to A1166C polymorphism of AT(1)R gene in hypertensive Kazakans.
authors.affiliation: Hypertension Institute of Xinjiang, Hypertension Unit of The People's Hospital of Xinjiang Uygur Autonomous Region, Urumuqi 830001, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Nan-Fang
authors.initials: NF
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Xin-Ling
authors.initials: XL
authors.lastname: Wang
authors.forename: Fei-Ya
authors.initials: FY
authors.lastname: Zu
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: De-Lian
authors.initials: DL
authors.lastname: Zhang
authors.forename: Ke-Ming
authors.initials: KM
authors.lastname: Zhou
mesh_terms: D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension; D011110:Polymorphism, Genetic; D044140:Receptor, Angiotensin, Type 1 / Q000235:genetics
chemical_list: D044140:Receptor, Angiotensin, Type 1