The diagnostic dilemma of thrombotic thrombocytopenic purpura/hemolytic uremic syndrome in the obstetric triage and emergency department: lessons from 4 tertiary hospitals.
OBJECTIVE
We report a series of occurrences of thrombotic thrombocytopenic purpura (TTP)/hemolytic uremic syndrome (HUS) in pregnancy that emphasizes early diagnosis.


METHODS
Fourteen pregnancies with TTP (n = 12) or HUS (n = 2) were studied. Analysis focused on clinical and laboratory findings on examination, initial diagnosis, and treatment.


RESULTS
There were 14 pregnancies in 12 patients; 2 cases of TTP were diagnosed as recurrent. Five women were admitted to the emergency department (ED), and 7 patients were admitted to an obstetrics triage. Patients who were evaluated by an obstetrician were treated initially for hemolysis, elevated liver enzymes and low platelets syndrome/preeclampsia, whereas patients who were seen in the ED had a diagnosis that is commonplace in the ED (panic attack, domestic violence, gastroenteritis). Latency from the onset of symptoms to diagnosis ranged from 1-7 days. Plasmapheresis treatments in early gestation resulted in favorable maternal-neonatal outcome. Maternal and perinatal mortality rates were 25% each.


CONCLUSIONS
TTP/HUS is a challenging diagnosis in obstetric triage and ED areas. We propose a management scheme that suggests how to triage patients for early diagnosis in pregnancy.
Stella
Caroline L
CL
University of Cincinnati College of Medicine, Department of Obstetrics & Gynecology, Cincinnati, OH, USA.
Dacus
John
J
Guzman
Edwin
E
Dhillon
Pushpinder
P
Coppage
Kristin
K
How
Helen
H
Sibai
Baha
B
D000328:Adult; D004636:Emergency Service, Hospital; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000175:diagnosis*; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis*; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis*; D012189:Retrospective Studies; D014218:Triage; D055815:Young Adult