title: DNA Cytosine demethylation: are we getting close?
abstract: Whether 5-methylcytosine (meC) can be enzymatically removed from vertebrate DNA has been the subject of extensive study and also some controversy. Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase.
authors.affiliation: Department of Biology, Swiss Federal Institutes of Technology (ETH), 8057 Zurich, Switzerland. jiricny@imcr.uzh.ch
authors.forename: Josef
authors.initials: J
authors.lastname: Jiricny
authors.forename: Mirco
authors.initials: M
authors.lastname: Menigatti
mesh_terms: D000818:Animals; D003564:Cytidine Deaminase / Q000378:metabolism; D003596:Cytosine / Q000378:metabolism*; D019175:DNA Methylation; D044502:Thymine DNA Glycosylase / Q000378:metabolism; D015027:Zebrafish
chemical_list: D003596:Cytosine; D044502:Thymine DNA Glycosylase; D003564:Cytidine Deaminase