title: Long-term topical cyclosporin A therapy in Thygeson's superficial punctate keratitis: a case report.
abstract: OBJECTIVE
  To describe a patient with Thygeson's superficial punctate keratitis successfully treated with long-term cyclosporin A.
  
  
  METHODS
  A 15-year-old boy presented with long-term ocular symptoms of foreign body sensation, burning, irritation, tearing, and transient photophobia. One year's treatment with steroidal agents had led to only partial improvement. Clinical and laboratory evaluation yielded a diagnosis of Thygeson's superficial punctate keratitis. Treatment with 0.5% topical cyclosporin A for the last 4.5 years has been associated with symptom resolution and corneal clearing, without side effects.
  
  
  CONCLUSIONS
  Topical cyclosporin A seems to effective and safe for the treatment of Thygeson's superficial punctuate keratitis and should be considered in selective cases when topical steroids fail or in there is a high risk of complications from long-term steroid treatment. Considering the chronicity of Thygeson's superficial punctate keratitis, further prospective studies of long-term cyclosporine A treatment are needed.
authors.affiliation: Department of Ophthalmology, Rabin Medical Center, Petach Tikva and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. rmurat95@yahoo.com.
authors.forename: Murat
authors.initials: M
authors.lastname: Hasanreisoglu
authors.forename: Rahamim
authors.initials: R
authors.lastname: Avisar