Estimated prevalence and risk factor for age-related maculopathy.
OBJECTIVE
To assess the estimate prevalence and risk factors for age-related maculopathy (ARM) in Seoul, Korea.


METHODS
We examined 9,530 subjects with, 40 years of age or older between January 2006 and December 2006 in Seoul, Korea. Subjects underwent fundus photography, clinical examinations (including blood analyses), and completed detailed questionnaires. Fundus images were graded according to definitions from the Wisconsin Age-Related Maculopathy Grading System.


RESULTS
ARM was present in 235 subjects, corresponding to an estimate prevalence of 2.46%. Hepatitis B infection (positive status for HBsAg and HBcAb), serum triglyceride levels and high density lipoprotein levels remained as significant risk factors after age-adjustment. Multivariate analyses showed that the prevalence of ARM was significantly higher in older subjects [odds ratio (OR) 1.134; 95% CI 1.114-1.154] and those who were seropositive for hepatitis B surface antigen (OR 2.566; 95% CI 1.519-4.335).


CONCLUSIONS
The estimated prevalence of ARM was 2.46%. Age and hepatitis B infection may increase the risk of ARM.
Roh
Mi In
MI
Department of Ophthalmology, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul 120-752, Korea.
Kim
Ji Hyun
JH
Byeon
Suk Ho
SH
Koh
Hyoung Jun
HJ
Lee
Sung Chul
SC
Kwon
Oh Woong
OW
D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008075:Lipoproteins, HDL / Q000097:blood; D008268:Macular Degeneration / Q000097:blood / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
D008075:Lipoproteins, HDL; D014280:Triglycerides