Aging skin is functionally anaerobic: importance of coenzyme Q10 for anti aging skin care.
The functional loss of mitochondria represents an inherent part in modern theories trying to explain the cutaneous aging process. The present study shows significant age-dependent differences in mitochondrial function of keratinocytes isolated from skin biopsies of young and old donors. Our data let us postulate that energy metabolism shifts to a predominantly non-mitochondrial pathway and is therefore functionally anaerobic with advancing age. CoQ10 positively influences the age-affected cellular metabolism and enables to combat signs of aging starting at the cellular level. As a consequence topical application of CoQ10 is beneficial for human skin as it rapidly improves mitochondrial function in skin in vivo.
Prahl
S
S
R&D, Beiersdorf AG, Hamburg, Germany.
Kueper
T
T
Biernoth
T
T
Wöhrmann
Y
Y
Münster
A
A
Fürstenau
M
M
Schmidt
M
M
Schulze
C
C
Wittern
K-P
KP
Wenck
H
H
Muhr
G-M
GM
Blatt
T
T
D000328:Adult; D000368:Aged; D000693:Anaerobiosis / Q000502:physiology*; D042967:Electron Transport Complex I / Q000378:metabolism; D042963:Electron Transport Complex II / Q000378:metabolism; D014450:Electron Transport Complex III / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000096:biosynthesis; D006019:Glycolysis; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism; D019344:Lactic Acid / Q000096:biosynthesis; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology*; D009840:Oligomycins / Q000494:pharmacology; D006180:Proton-Translocating ATPases / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D012867:Skin / Q000254:growth & development* / Q000528:radiation effects / Q000648:ultrastructure; D015595:Skin Aging / Q000502:physiology*; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D051272:Glucose Transporter Type 1; D009840:Oligomycins; D017382:Reactive Oxygen Species; D014451:Ubiquinone; D019344:Lactic Acid; D042963:Electron Transport Complex II; D006180:Proton-Translocating ATPases; D042967:Electron Transport Complex I; D014450:Electron Transport Complex III; C024989:coenzyme Q10; D005947:Glucose