title: Rassf family of tumor suppressor polypeptides.
abstract: The Rassf1-6 polypeptides each contain a Ras/Rap association domain, which enables binding to several GTP-charged Ras-like GTPases, at least in vitro or when overexpressed. The Ras/Rap association domains are followed by SARAH domains, which mediate Rassf heterodimerization with the Mst1/2 protein kinases. Rassf1A is unequivocally a tumor suppressor, and all Rassf proteins behave like tumor suppressors, exhibiting epigenetic silencing of expression in many human cancers and pro-apoptotic and/or anti-proliferative effects when re-expressed in tumor cell lines. Herein, we review the binding of the Rassf polypeptides to Ras-like GTPases and the Mst1/2 kinases and their role in Rassf function.
authors.affiliation: Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. avruch@molbio.mgh.harvard.edu
authors.forename: Joseph
authors.initials: J
authors.lastname: Avruch
authors.forename: Ramnik
authors.initials: R
authors.lastname: Xavier
authors.forename: Nabeel
authors.initials: N
authors.lastname: Bardeesy
authors.forename: Xian-Feng
authors.initials: XF
authors.lastname: Zhang
authors.forename: Maria
authors.initials: M
authors.lastname: Praskova
authors.forename: Dawang
authors.initials: D
authors.lastname: Zhou
authors.forename: Fan
authors.initials: F
authors.lastname: Xia
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation; D019281:Dimerization; D044127:Epigenesis, Genetic; D020558:GTP Phosphohydrolases / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family; D009369:Neoplasms / Q000378:metabolism*; D010455:Peptides / Q000737:chemistry; D011485:Protein Binding; D025521:Tumor Suppressor Proteins / Q000378:metabolism / Q000502:physiology*
chemical_list: D010455:Peptides; C411762:RASSF1 protein, human; D025521:Tumor Suppressor Proteins; D020558:GTP Phosphohydrolases