Aripiprazole augmentation in poor insight obsessive-compulsive disorder: a case report.
BACKGROUND
Obsessive-compulsive disorder is associated with a relevant impairment in social and interpersonal functioning and severe disability. This seems to be particularly true for the poor insight subtype, characterised by a lack of consciousness of illness and, consequently, compliance with treatment. Poor responsiveness to serotonergic drugs in poor insight obsessive-compulsive patients may also require an augmentation therapy with atypical antipsychotics.


METHODS
We reviewed a case in which a patient with a long history of poor insight obsessive-compulsive disorder was treated with a high dosage of serotonin reuptake inhibitors.


RESULTS
The treatment resulted in a poor outcome. This patient was therefore augmentated with aripiprazole.


CONCLUSIONS
Doctors should consider aripiprazole as a possible augmentation strategy for serotonergic poor responder obsessive-compulsive patients, but further research on these subjects is needed.
Fornaro
Michele
M
Dipartimento di Neuroscienze, Oftalmologia e Genetica (DINOG), Sezione di Psichiatria, Università di Genova, Italy. dott.fornaro@gmail.com
Gabrielli
Filippo
F
Mattei
Chiara
C
Vinciguerra
Valentina
V
Fornaro
Pantaleo
P