title: Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea.
abstract: Prulifloxacin, the prodrug of ulifloxacin (active component), is a newer fluoroquinolone with broad activity against enteric and nonenteric gram-negative bacilli. Ulifloxacin and other oral comparator agents were tested for activity against 582 gastroenteritis strains from global surveillance studies. Ulifloxacin was highly active against Escherichia coli, Salmonella spp., Shigella spp., Yersinia spp., Vibrio spp., Aeromonas spp., and Plesiomonas spp. (MIC(50)s and MIC(90)s, <or=0.03 microg/ml and <or=0.06 microg/ml, respectively). Only rare Aeromonas spp., Campylobacter spp., and E. coli displayed elevated MIC results (>or=4 microg/ml). Ciprofloxacin exhibited similar activity but was two- to fourfold less potent. Presently approved for clinical use in certain European countries and Japan, ulifloxacin was the most active of the antimicrobial agents tested against these gastroenteritis-causing pathogens.
authors.affiliation: JMI Laboratories, 345 Beaver Kreek Centre, North Liberty, Iowa 52317, USA.
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Fritsche
authors.forename: Douglas J
authors.initials: DJ
authors.lastname: Biedenbach
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003967:Diarrhea / Q000188:drug therapy* / Q000382:microbiology; D004148:Dioxolanes / Q000494:pharmacology*; D024841:Fluoroquinolones / Q000494:pharmacology*; D005759:Gastroenteritis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D010879:Piperazines / Q000494:pharmacology*; D011159:Population Surveillance; D011355:Prodrugs / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D004148:Dioxolanes; D024841:Fluoroquinolones; D010879:Piperazines; D011355:Prodrugs; C074191:prulifloxacin