title: Synthesized phosphorylated and aminated derivatives of fucoidan and their potential antioxidant activity in vitro.
abstract: Three sulfated polysaccharide derivatives (phosphorylated and aminated fucoidan) were synthesized, and their potential antioxidant activities were investigated employing various established in vitro systems. Two methods were used in phosphorylation fucoidan: polyphosphoric acid and POCl(3) method. Aminated fucoidan was prepared using the epichlorohydrin and ammonia water. All fucoidan derivatives possessed considerable antioxidant activity, and exhibited stronger antioxidant ability than fucoidan in certain tests. The phosphorylated fucoidan showed stronger hydroxyl radical and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and reducing power. The mechanism on influence the antioxidant activity of samples of phosphate and amino group was indicated.
authors.affiliation: Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Quanbin
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhongshan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jingjing
authors.initials: J
authors.lastname: Zhang
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Li
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000378:metabolism; D016166:Free Radical Scavengers / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000378:metabolism; D000070116:Lotus / Q000737:chemistry; D010084:Oxidation-Reduction / Q000187:drug effects; D010766:Phosphorylation / Q000187:drug effects; D010851:Picrates / Q000378:metabolism; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D011134:Polysaccharides; D013481:Superoxides; D017665:Hydroxyl Radical; C007789:fucoidan; C004931:1,1-diphenyl-2-picrylhydrazyl