title: Preliminary biological evaluations of new thalidomide analogues for multiple sclerosis application.
abstract: The present work deals with the synthesis of a new series of thalidomide derivatives for therapeutic applications. These compounds were evaluated in vitro on a human endothelial cell line EA.hy926 for their antiproliferative potential and in vivo on an experimental animal multiple sclerosis model called EAE as angiogenesis inhibitors. The preliminary results obtained on EAE assays seem to validate that anti-angiogenesis compounds could be promising tools for the treatment of MS.
authors.affiliation: Université d'Avignon, Laboratoire de Chimie Bioorganique et des Systèmes Moléculaires Vectoriels, 33 rue Louis Pasteur, 84000 Avignon, France. christine.pepin@univ-avignon.fr
authors.forename: Christiane
authors.initials: C
authors.lastname: Contino-Pépin
authors.forename: Audrey
authors.initials: A
authors.lastname: Parat
authors.forename: Sandrine
authors.initials: S
authors.lastname: Périno
authors.forename: Christine
authors.initials: C
authors.lastname: Lenoir
authors.forename: Michel
authors.initials: M
authors.lastname: Vidal
authors.forename: Hervé
authors.initials: H
authors.lastname: Galons
authors.forename: Stephen
authors.initials: S
authors.lastname: Karlik
authors.forename: Bernard
authors.initials: B
authors.lastname: Pucci
mesh_terms: D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy*; D042783:Endothelial Cells / Q000378:metabolism; D006801:Humans; D008956:Models, Chemical; D009103:Multiple Sclerosis / Q000188:drug therapy*; D009389:Neovascularization, Pathologic; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D013792:Thalidomide