title: A case of benign intraductal papillary mucinous neoplasm of the pancreas containing two major subtypes.
abstract: Here we report a case of benign intraductal papillary-mucinous neoplasm (IPMN) of the pancreas containing two major subtypes. A 73-year-old man underwent pancreatoduodenectomy for a cystic mass, 5.0 cm in diameter. Histopathologic examinations revealed that IPMN was composed of gastric-type adenoma and intestinal-type borderline lesion. Marked intraluminal nodular growth was observed in the center of the tumor composed of intestinal-type cells positive for MUC2. Our observations suggest that gastric-type epithelium is a precursor of intestinal-type lesions in the stepwise progression of IPMN.
authors.affiliation: Department of Surgery, Saiseikai Kure Hospital, Department of Surgical Oncology, Gifu Graduate Sch. Med, 1-1 Yanagido Gifu 501-1194, Gifu, Japan. ysanadasurg@hotmail.com
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Sanada
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002760:Cholangiopancreatography, Endoscopic Retrograde; D006801:Humans; D008297:Male; D018198:Mixed Tumor, Malignant / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D055262:Mucin-2 / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D016577:Pancreaticoduodenectomy; D014057:Tomography, X-Ray Computed
chemical_list: D055262:Mucin-2