Synthesis of water-soluble phthalocyanines bearing four or eight D-galactose units.
The synthesis and structural characterization of two glycophthalocyanines with four or eight unprotected D-galactose units is reported. The sugar units are linked to the macrocycle via the hydroxyl group located at C-6. The water solubility promoted by the carbohydrate moieties provides a potential application of these phthalocyanine derivatives as photosensitizers in photodynamic therapy.
Soares
Ana R M
AR
Departamento de Química, QOPNA, Universidade de Aveiro, Aveiro, Portugal.
Tomé
João P C
JP
Neves
Maria G P M S
MG
Tomé
Augusto C
AC
Cavaleiro
José A S
JA
Torres
Tomás
T
D005690:Galactose / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D054833:Isoindoles; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012995:Solubility; D014867:Water / Q000737:chemistry*
D007211:Indoles; D054833:Isoindoles; D014867:Water; C013647:phthalocyanine; D005690:Galactose