title: Medial temporal lobe glutathione concentration in first episode psychosis: a 1H-MRS investigation.
abstract: Glutathione (GSH) is implicated in the pathophysiology of schizophrenia. Previous brain spectroscopy studies, however, have been inconsistent, and there is little data available from first episode psychosis patients. This study compared brain GSH in a first episode cohort (n=30) to controls (n=18), using magnetic resonance spectroscopy (MRS), examining a temporal lobe voxel. Short-echo (TE 30 ms) acquisition proton MRS was performed on a 3T clinical magnetic resonance scanner. Comparison of the first-episode and control groups' GSH concentrations revealed a significant main effect of group (F(1,46)=4.7, p=0.035), but no main effect of hemisphere (F(1,46)=2.3, p=0.137) or group-by-side interactions (F(1,46)=0.4, p=0.513). Medial temporal lobe GSH concentrations in the first episode group were 22% higher than those in the control group. This study provides further evidence of significant perturbations in brain GSH in first episode psychosis, and supports a broader involvement of GSH in the pathophysiology of schizophrenia.
authors.affiliation: Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia. sjwood@unimelb.edu.au
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wood
authors.forename: Gregor E
authors.initials: GE
authors.lastname: Berger
authors.forename: R Mark
authors.initials: RM
authors.lastname: Wellard
authors.forename: Tina-Marie
authors.initials: TM
authors.lastname: Proffitt
authors.forename: Mirabel
authors.initials: M
authors.lastname: McConchie
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
authors.forename: Patrick D
authors.initials: PD
authors.lastname: McGorry
authors.forename: Christos
authors.initials: C
authors.lastname: Pantelis
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D005260:Female; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009525:Niacin; D011618:Psychotic Disorders / Q000378:metabolism*; D012882:Skin Tests; D013702:Temporal Lobe / Q000737:chemistry*; D055815:Young Adult
chemical_list: D009525:Niacin; D005978:Glutathione