title: Soluble CD26 and CD30 plasma levels in HIV infected patients with and without GB virus type C coinfection.
abstract: GB virus type C (GBV-C) probably influences HIV infection associated disease by either directly inhibiting HIV replication or enhancing the immune competence to cope with HIV. Still the definitive mechanisms of this inhibitory effect need to be identified. To address the possibility of immune modulating effects of GBV-C coinfection in HIV patients we evaluated plasma levels of soluble (s) CD26 and CD30 in HIV infected patients with and without GBV-C. Cross-sectional comparison of sCD26 and sCD30 levels among 6 HIV/GBV-C coinfected, 11 HIV mono-infected and 13 healthy controls was carried out. We used a commercial EIA to evaluate sCD26 and scD30 and a RT-PCR assay to detect active GBV-C infection. The Mann-Whitney U test was used for statistical analysis. No statistically significant differences were observed in levels of sCD26 and sCD30 in plasma of HIV infected patients with and without GBV-C viremia. GBV-C infection does not appear to influence the sCD26 and sCD30 levels.
authors.affiliation: Department of Immunology, School of Medicine, Tarbiat Modarres University, P.O. Box 14115-111, Tehran, Iran.
authors.forename: Haji-Molla-Hoseini
authors.initials: HM
authors.lastname: Mostafa
authors.forename: Pourfathollah
authors.initials: P
authors.lastname: Ali-Akbar
authors.forename: Soheili
authors.initials: S
authors.lastname: Zahra
authors.forename: Mohraz
authors.initials: M
authors.lastname: Minoo
authors.forename: Amini
authors.initials: A
authors.lastname: Sedigheh
authors.forename: Aghaiepour
authors.initials: A
authors.lastname: Mahnaz
authors.forename: Samiee
authors.initials: S
authors.lastname: Shahram
authors.forename: Nikoogoftar
authors.initials: N
authors.lastname: Mahin
authors.forename: Moghtadaie
authors.initials: M
authors.lastname: Mina
mesh_terms: D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D018819:Dipeptidyl Peptidase 4 / Q000097:blood*; D005260:Female; D018178:Flaviviridae Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D029407:GB virus C / Q000235:genetics / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000276:immunology* / Q000821:virology; D006525:Hepatitis, Viral, Human / Q000150:complications* / Q000276:immunology* / Q000821:virology; D006801:Humans; D017730:Ki-1 Antigen / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D014766:Viremia / Q000150:complications / Q000276:immunology / Q000821:virology
chemical_list: D017931:DNA Primers; D017730:Ki-1 Antigen; D012367:RNA, Viral; C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4