Heightened cytotoxic responses and impaired biogenesis contribute to early pathogenesis in the oral mucosa of simian immunodeficiency virus-infected rhesus macaques.
Simian immunodeficiency virus (SIV) infection disseminated into the oropharyngeal tissues of rhesus macaques 6 weeks following intravenous inoculation. Severe local CD4(+) T-cell depletion coincided with increases in NK cell and proinflammatory biomarkers and the disruption of growth-associated gene transcription, demonstrating the rapid establishment of pathogenesis in the oral mucosa.
George
Michael D
MD
Department of Medical Microbiology, School of Medicine, University of California, Davis, California 95616, USA. mdgeorge@ucdavis.edu
Verhoeven
David
D
Sankaran
Sumathi
S
Glavan
Tiffany
T
Reay
Elizabeth
E
Dandekar
Satya
S
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D020869:Gene Expression Profiling; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008253:Macaca mulatta; D009061:Mouth Mucosa / Q000276:immunology* / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology* / Q000472:pathogenicity*
D016207:Cytokines