Enteric infection meets intestinal function: how bacterial pathogens cause diarrhoea.
Infectious diarrhoea is a significant contributor to morbidity and mortality worldwide. In bacterium-induced diarrhoea, rapid loss of fluids and electrolytes results from inhibition of the normal absorptive function of the intestine as well as the activation of secretory processes. Advances in the past 10 years in the fields of gastrointestinal physiology, innate immunity and enteric bacterial virulence mechanisms highlight the multifactorial nature of infectious diarrhoea. This review explores the various mechanisms that contribute to loss of fluids and electrolytes following bacterial infections, and attempts to link these events to specific virulence factors and toxins.
Viswanathan
V K
VK
Department of Veterinary Science & Microbiology, University of Arizona, Tucson, Arizona 85721, USA.
Hodges
Kim
K
Hecht
Gail
G
D001424:Bacterial Infections / Q000276:immunology / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000276:immunology / Q000378:metabolism / Q000382:microbiology*; D005759:Gastroenteritis / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D017136:Ion Transport / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology
D001427:Bacterial Toxins