title: Association of chemokines receptor (CCR5 Delta32) in idiopathic recurrent miscarriages among north Indians.
abstract: OBJECTIVE
  Human reproduction is a complex process involving multiple factors for the success of pregnancy. Chemokines are one of the immunomodulators which may determine pregnancy outcome. In the present study, we have tested genetic association between CCR5 Delta32 polymorphism and idiopathic recurrent miscarriages (IRM) among north Indians.
  
  
  METHODS
  Two hundred patients and 300 age, sex and ethnically matched controls were genotyped for CCR5 Delta32 polymorphism, genotype and allele frequencies were compared in both the groups.
  
  
  RESULTS
  IRM patients had a three times higher (5.5 vs. 1.7%) frequency of heterozygote genotype (P = 0.0335, OR = 3.43; 95% CI = 1.17-10.04). Allele frequency in IRM patients was 3.7 and 0.83% among controls and the differences were statistically significant (P = 0.0349, OR = 3.37; 95% CI = 1.16-9.76).
  
  
  CONCLUSIONS
  Our results demonstrated that it had a higher frequency of CCR5 Delta32 at allelic level suggesting a possible susceptibility trend (OR = 3.43) and CCR5 Delta32 may be a potential genetic risk factor for IRM.
authors.affiliation: Department of Biotechnology, Bundelkhand University, Jhansi, UP, India.
authors.forename: Farah
authors.initials: F
authors.lastname: Parveen
authors.forename: Gaurav
authors.initials: G
authors.lastname: Tripathi
authors.forename: Bhanumati
authors.initials: B
authors.lastname: Singh
authors.forename: Suraksha
authors.initials: S
authors.lastname: Agrawal
mesh_terms: D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007194:India; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D055815:Young Adult
chemical_list: D019713:Receptors, CCR5