title: [Prevention of oxaliplatin-related neurotoxicity by glutathione infusions].
abstract: We have used glutathione for prevention of oxaliplatin-related neurotoxicity with reference to the article of Cascinu et al. We investigated oxaliplatin-related neurotoxicity in Kariya Toyota General Hospital(KTGH)and compared with the data described in the article of Gamelin about the severity of its neurotoxicity. Grade 3 neurotoxicity was observed in only 5 of 44 patients(11.4%). The median number of cycles and cumulative dose of oxaliplatin were 12 cycles(5-27 / cycles)and 802.2(273.2-1,952.4)mg/m(2), respectively, at Grade 3 neuropathy. We evaluated retrospectively neuro-toxicity grade at cumulative oxaliplatin doses of approximately 500-520 mg/m(2). The severity of neurotoxicity observed in KTGH was significantly lower than in the group without Ca/Mg. We found no difference between the group with glutathione and / with Ca/Mg. Glutathione infusions seemed to prevent oxaliplatin-related neurotoxicity.
authors.affiliation: Dept. of Pharmacy, Kariya Toyota General Hospital, Japan.
authors.forename: Norio
authors.initials: N
authors.lastname: Takimoto
authors.forename: Shiho
authors.initials: S
authors.lastname: Sugawara
authors.forename: Akiko
authors.initials: A
authors.lastname: Iida
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakakibara
authors.forename: Kenji
authors.initials: K
authors.lastname: Mori
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Sugiura
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Moritsugu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Hayakawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamamura
authors.forename: Mamoru
authors.initials: M
authors.lastname: Adachi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003110:Colonic Neoplasms / Q000188:drug therapy; D005260:Female; D005978:Glutathione / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000517:prevention & control*; D009944:Organoplatinum Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D000077150:Oxaliplatin
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D005978:Glutathione