title: "Gender paradox" in outcome after percutaneous coronary intervention with paclitaxel eluting stents.
abstract: OBJECTIVE
  To evaluate in-hospital and long-term outcome of women undergoing percutaneous coronary intervention (PCI) with paclitaxel-eluting stents (PES) as compared to men and historic controls treated with bare metal stents.
  
  
  RESULTS
  Eight-hundred and ten (810) consecutive patients (642 men and 168 women) with PES were analysed and also compared with 3,515 patients (2,811 men and 704 women) with at least one bare metal stent in the three years previous. In the PES group, women were significantly older than men (mean age of 68+/-10 vs. 63+/-10 years, p<0.001), with more diabetes (39.9 vs. 29.7%, p<0.05), smaller treated vessels (<2.5 mm in 34.9 vs. 24.8%, p=0.003), more left-anterior descending lesions (56.6 vs. 43.2%, p<0.001). More men had multivessel disease (78.8 vs. 62.5%, p<0,001), dyslipidaemia (73.2 versus 65.4%, p<0.05), smoking habit (74.3 versus 34.5%, p<0.001) or prior revascularisation (49.7 versus 36.1%, p<0.05). Compared to bare metal stents, similar higher risk features were recorded in women over time. No gender specific differences in in-hospital outcome were observed. At 12 months the rates of cardiac death, acute myocardial infarction (AMI) and late thrombosis were respectively 2.0%, 3.7% and 0% in women and 2.1%, 3.2%, and 1.2% in men (all p=NS).
  
  
  CONCLUSIONS
  Albeit with worse baseline clinical and angiographic characteristics in women, very high immediate success rates and a positive outcome can be achieved in both sexes after PES.
authors.affiliation: Department of Invasive Cardiology, Istituto Clinico Humanitas Mirasole Spa, Rozzano, Milan, Italy.
authors.forename: Patrizia
authors.initials: P
authors.lastname: Presbitero
authors.forename: Guido
authors.initials: G
authors.lastname: Belli
authors.forename: Dennis
authors.initials: D
authors.lastname: Zavalloni
authors.forename: Marco L
authors.initials: ML
authors.lastname: Rossi
authors.forename: Veronica
authors.initials: V
authors.lastname: Lisignoli
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Barberis
authors.forename: Gabriele L
authors.initials: GL
authors.lastname: Gasparini
authors.forename: Melania
authors.initials: M
authors.lastname: Scatturin
authors.forename: Emanuela
authors.initials: E
authors.lastname: Morenghi
authors.forename: Paolo
authors.initials: P
authors.lastname: Pagnotta
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000706:statistics & numerical data*; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000628:therapy*; D023903:Coronary Restenosis / Q000000981:diagnostic imaging / Q000453:epidemiology; D016208:Databases, Factual; D054855:Drug-Eluting Stents / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D008297:Male; D008670:Metals; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D011237:Predictive Value of Tests; D012307:Risk Factors; D017678:Sex Distribution; D012737:Sex Factors; D016896:Treatment Outcome
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D008670:Metals; D017239:Paclitaxel