title: Acetylcholinesterase activity of alkaloids from the leaves of Waltheria brachypetala.
abstract: Chemical investigation of the leaves of Waltheria brachypetala Turks (Sterculiaceae) resulted in the isolation of quinolinone alkaloids, waltherione-A, waltherione-B (N-methylwaltherione-A), 8-methoxyflindersine, and the cyclic peptide alkaloid waltherine. The inhibition of activity of acetylcholinesterase (AChE) by the alkaloids was evaluated. Waltherione-A, waltherione-B and waltherine showed significant activity.
authors.affiliation: Intituto de Química, Universidade Federal da Bahia, Campus de Ondina, Salvador (BA), Brazil.
authors.forename: Murilo M C
authors.initials: MM
authors.lastname: Lima
authors.forename: Jorge A
authors.initials: JA
authors.lastname: López
authors.forename: Jorge M
authors.initials: JM
authors.lastname: David
authors.forename: Eliezer P
authors.initials: EP
authors.lastname: Silva
authors.forename: Ana M
authors.initials: AM
authors.lastname: Giulietti
authors.forename: Luciano P
authors.initials: LP
authors.lastname: de Queiroz
authors.forename: Juceni P
authors.initials: JP
authors.lastname: David
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019660:Malvaceae / Q000737:chemistry*; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002800:Cholinesterase Inhibitors; D010456:Peptides, Cyclic; D011804:Quinolines; C540623:waltherine; C502881:waltherione-A; C540622:waltherione-B; D000110:Acetylcholinesterase