title: MicroRNA profile changes in human immunodeficiency virus type 1 (HIV-1) seropositive individuals.
abstract: MicroRNAs (miRNAs) play diverse roles in regulating cellular and developmental functions. We have profiled the miRNA expression in peripheral blood mononuclear cells from 36 HIV-1 seropositive individuals and 12 normal controls. The HIV-1-positive individuals were categorized operationally into four classes based on their CD4+ T-cell counts and their viral loads. We report that specific miRNA signatures can be observed for each of the four classes.
authors.affiliation: Molecular Virology Section, Laboratory of Molecular Microbiology National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892, USA. houzetl@niaid.nih.gov
authors.forename: Laurent
authors.initials: L
authors.lastname: Houzet
authors.forename: Man Lung
authors.initials: ML
authors.lastname: Yeung
authors.forename: Valery
authors.initials: V
authors.lastname: de Lame
authors.forename: Dhara
authors.initials: D
authors.lastname: Desai
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Smith
authors.forename: Kuan-Teh
authors.initials: KT
authors.lastname: Jeang
mesh_terms: D015331:Cohort Studies; D005786:Gene Expression Regulation; D015658:HIV Infections / Q000097:blood* / Q000276:immunology; D006679:HIV Seropositivity; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D035683:MicroRNAs / Q000097:blood* / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism
chemical_list: D035683:MicroRNAs