Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes.
New findings show that a subpopulation of mucosal ROR gammat+ cells expresses natural killer cell receptors and produces interleukin 22. These innate immune cells may be pivotal in maintaining mucosal homeostasis.
Malmberg
Karl-Johan
KJ
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, S-14186 Stockholm, Sweden.
Ljunggren
Hans-Gustaf
HG
D000818:Animals; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000382:microbiology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism; D008221:Lymphoid Tissue / Q000276:immunology; D051379:Mice; D055627:Natural Cytotoxicity Triggering Receptor 1 / Q000378:metabolism; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D055607:Receptors, Natural Killer Cell / Q000378:metabolism*; D018168:Receptors, Retinoic Acid / Q000276:immunology*; D011988:Receptors, Thyroid Hormone / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D000097043:Interleukin-22
D007378:Interleukins; D055627:Natural Cytotoxicity Triggering Receptor 1; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D055607:Receptors, Natural Killer Cell; D018168:Receptors, Retinoic Acid; D011988:Receptors, Thyroid Hormone; D000097043:Interleukin-22; C112260:NCR1 protein, human; C539900:RORC protein, human; C539901:Rorc protein, mouse