title: [Relationship between Ghrelin polymorphism and serum lipoprotein levels in Han Chinese with or without coronary heart disease risk factors].
abstract: OBJECTIVE
  To investigate the relationship between polymorphism of Ghrelin gene and serum levels of lipoprotein in Han Chinese with or without coronary heart disease (CHD) risk factors.
  
  
  METHODS
  PCR restriction fragment length polymorphism assay was used to detect the distribution of genotypes of Ghrelin gene in 225 Han Chinese (40 to 69 years-old) with CHD risk factors, 78 subjects without CHD risk factors served as normal controls. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein (VLDL) were measured to analyze the relationship with the polymorphism of Ghrelin gene.
  
  
  RESULTS
  Ghrelin genotype frequencies of AA, AG, GG (0.975, 0.025, 0.00 in control group and 0.956, 0.040, 0.004 in the high-risk group, all P > 0.05) as well as the allele frequencies of A, G (0.987, 0.013 in control group and 0.976, 0.024 in the high-risk group, all P > 0.05) were similar between the groups. HDL-C levels of the Arg/Gln carriers were significantly lower than those of Arg/Arg carriers in control group and in the high-risk group (all P < 0.05).
  
  
  CONCLUSIONS
  Arg/Gln carriers were associated lower HDL-C levels in Han Chinese.
authors.affiliation: Department of Endocrinology, Second Affiliated Hospital of Medical School, Xi'an Jiao Tong University, Xi'an 710004, China. xx662006@126.com
authors.forename: Xuan
authors.initials: X
authors.lastname: Xie
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Yu-huan
authors.initials: YH
authors.lastname: Wang
authors.forename: Jun-hong
authors.initials: JH
authors.lastname: Wang
authors.forename: Chun-hong
authors.initials: CH
authors.lastname: Zhang
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Ni
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Yuan
mesh_terms: D000328:Adult; D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D008076:Cholesterol, HDL / Q000097:blood*; D003327:Coronary Disease / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D054439:Ghrelin / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D008076:Cholesterol, HDL; D054439:Ghrelin