title: Disseminated melanoma in a dog with involvement of leptomeninges and bone marrow.
abstract: An 11-year-old, Black and Tan Coonhound dog was presented with a history of lameness of the right hind leg for 2 months, osteolysis in the right distal femur, a pulmonary mass, and a presumptive diagnosis of osteosarcoma. By cytologic examination, neoplastic melanocytes were noted from fine needle aspirates of the femoral and pulmonary masses. Postmortem examination revealed a disseminated melanoma involving the right femoral bone marrow, lung, multiple lymph nodes, and adrenal gland, with diffuse infiltration of the leptomeninges of the brain and spinal cord. This case report describes a unique presentation of canine melanoma, which in some ways resembles leptomeningeal melanomatosis, a rare human melanoma variant.
authors.affiliation: Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, MO 65211, USA. kimdy@missouri.edu
authors.forename: D Y
authors.initials: DY
authors.lastname: Kim
authors.forename: A B
authors.initials: AB
authors.lastname: Royal
authors.forename: J A
authors.initials: JA
authors.lastname: Villamil
mesh_terms: D000818:Animals; D019046:Bone Marrow Neoplasms / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D008545:Melanoma / Q000473:pathology / Q000662:veterinary*; D008577:Meningeal Neoplasms / Q000473:pathology / Q000662:veterinary*