title: A two-year clinical lifestyle intervention program for weight loss in obesity.
abstract: BACKGROUND
  In recent randomised prospective studies, lifestyle intervention induced a weight loss of approximately 5%.
  
  
  OBJECTIVE
  To describe and evaluate a 2-year on-going group intervention program in clinical practice in terms of weight loss and changes in metabolic risk factors, i.e. sagital abdominal diameter (SAD), triglycerides, fasting blood glucose and blood pressure.
  
  
  METHODS
  The aim of the intervention program was to motivate lifestyle changes concerning food intake and physical activity. The emphasis was on lifestyle modification, followed up at regular visits during 2 years. Subjects evaluated were 100 women with mean BMI 37.6 kg/m(2) and 26 men with mean BMI 36.5 kg/m(2).
  
  
  RESULTS
  One hundred of 151 enrolled women and 26 of 36 men completed the program. Mean weight decreased by 3.8 kg in women (from 103.5 to 99.7, p<0.001) and 4.4 kg in men (from 116.5 to 112.1, p<0.05), respectively. SAD decreased by 5% (p=0.001 in women, p=0.01 in men), and triglycerides by 16% in women (p=0.01) and 24% in men (p=0.001), however systolic and diastolic blood pressure increased slightly but significantly.
  
  
  CONCLUSIONS
  It is possible to perform a clinical lifestyle intervention program for outpatients on an ongoing basis with weight loss, lowered SAD and triglycerides, and a similar or lower dropout rate compared to clinical trials.
authors.affiliation: Department of Public Health and Caring Sciences/Clinical Nutrition and Metabolism, Uppsala University, Uppsala, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Andersson
authors.forename: Brita
authors.initials: B
authors.lastname: Karlström
authors.forename: Susanne
authors.initials: S
authors.lastname: Fredén
authors.forename: Helena
authors.initials: H
authors.lastname: Petersson
authors.forename: Margareta
authors.initials: M
authors.lastname: Ohrvall
authors.forename: Björn
authors.initials: B
authors.lastname: Zethelius