title: G72/G30 (DAOA) and juvenile-onset mood disorders.
abstract: The chromosome 13q region has been linked to bipolar disorder in a number of genome scans as well as focused linkage studies. Previously we identified linkage to the 13q32 region in a genome scan of 146 affected sibling pair families from Hungary with juvenile-onset mood disorders. Within this region are the overlapping genes G72/G30, with G72 now officially named as D-amino-acid oxidase activator (DAOA). This locus has been associated with panic disorder, schizophrenia, and bipolar disorder. In this study, we tested for association to 11 markers in these genes and mood disorders in a sample of 646 nuclear families identified with a proband with onset of a mood disorder before 14.9 years of age. We identified evidence for association to three markers within the gene (rs2391191, rs3918341, rs1935062), two of which had been associated with bipolar disorder in previous studies. When corrected for the number of markers tested, the results were no longer significant, however the prior evidence for association of this gene in multiple studies points to this gene as a potential contributor to juvenile-onset mood disorders.
authors.affiliation: Genetics and Development Division, Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada.
authors.forename: Lissette
authors.initials: L
authors.lastname: Gomez
authors.forename: Karen
authors.initials: K
authors.lastname: Wigg
authors.forename: Yu
authors.initials: Y
authors.lastname: Feng
authors.forename: Eniko
authors.initials: E
authors.lastname: Kiss
authors.forename: Krisztina
authors.initials: K
authors.lastname: Kapornai
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Tamás
authors.forename: László
authors.initials: L
authors.lastname: Mayer
authors.forename: Ildikó
authors.initials: I
authors.lastname: Baji
authors.forename: Gabriella
authors.initials: G
authors.lastname: Daróczi
authors.forename: István
authors.initials: I
authors.lastname: Benák
authors.forename: Viola Osváth
authors.initials: VO
authors.lastname: Kothencné
authors.forename: Edit
authors.initials: E
authors.lastname: Dombovári
authors.forename: Emília
authors.initials: E
authors.lastname: Kaczvinszk
authors.forename: Márta
authors.initials: M
authors.lastname: Besnyo
authors.forename: Julia
authors.initials: J
authors.lastname: Gádoros
authors.forename: Nicole
authors.initials: N
authors.lastname: King
authors.forename: Judit
authors.initials: J
authors.lastname: Székely
authors.forename: Maria
authors.initials: M
authors.lastname: Kovacs
authors.forename: Agnes
authors.initials: A
authors.lastname: Vetró
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Barr
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D002648:Child; D003605:D-Amino-Acid Oxidase / Q000235:genetics*; D005786:Gene Expression Regulation; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D015810:Linkage Disequilibrium / Q000235:genetics; D015201:Meta-Analysis as Topic; D019964:Mood Disorders / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D003605:D-Amino-Acid Oxidase