title: Neuromedin U is overexpressed in pancreatic cancer and increases invasiveness via the hepatocyte growth factor c-Met pathway.
abstract: Neuromedin U (NmU) is a bioactive peptide, ubiquitously expressed in the gastrointestinal tract. Here, we analyzed the role of NmU in pancreatic ductal adenocarcinoma (PDAC) pathogenesis. NmU and NmU receptor-2 mRNA were significantly overexpressed in PDAC and in metastatic tissues. NmU and NmU receptor-2 were localized predominantly in cancer cells. NmU serum levels decreased after tumor resection. Although NmU exerted no effects on cancer cell proliferation, it induced c-Met and a trend towards increased invasiveness as well as an increased hepatocyte growth factor (HGF)-mediated scattering. Thus, NmU may be involved in the HGF-c-Met paracrine loop regulating cell migration, invasiveness and dissemination of PDAC.
authors.affiliation: Department of Surgery, Technische Universität München, Ismaningerstrasse 22, Munich, Germany.
authors.forename: Knut
authors.initials: K
authors.lastname: Ketterer
authors.forename: Bo
authors.initials: B
authors.lastname: Kong
authors.forename: Dietwalt
authors.initials: D
authors.lastname: Frank
authors.forename: Nathalia A
authors.initials: NA
authors.lastname: Giese
authors.forename: Andrea
authors.initials: A
authors.lastname: Bauer
authors.forename: Jörg
authors.initials: J
authors.lastname: Hoheisel
authors.forename: Murray
authors.initials: M
authors.lastname: Korc
authors.forename: Jörg
authors.initials: J
authors.lastname: Kleeff
authors.forename: Christoph W
authors.initials: CW
authors.lastname: Michalski
authors.forename: Helmut
authors.initials: H
authors.lastname: Friess
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D021441:Carcinoma, Pancreatic Ductal / Q000473:pathology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D017228:Hepatocyte Growth Factor / Q000502:physiology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009479:Neuropeptides / Q000097:blood / Q000235:genetics / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D019859:Proto-Oncogene Proteins c-met / Q000235:genetics / Q000502:physiology*; D017981:Receptors, Neurotransmitter / Q000235:genetics / Q000502:physiology
chemical_list: D009479:Neuropeptides; D017981:Receptors, Neurotransmitter; C082444:neuromedin U receptor; C056900:neuromedin U; D017228:Hepatocyte Growth Factor; D019859:Proto-Oncogene Proteins c-met