title: Search for serum biomarkers associated with abdominal aortic aneurysm growth--a pilot study.
abstract: BACKGROUND
  Serological biomarkers could reflect asymptomatic infrarenal aortic aneurysm (AAA) activity and guide patient management.
  
  
  METHODS
  Serum concentrations of C-reactive protein (CRP), alpha 1-antitrypsin and lipoprotein(a) were measured in blood samples from 35 AAA patients and 35 controls and correlated with the aortic diameter and AAA growth in the previous 12 months. We found a positive correlation between CRP and AAA diameter (r=0.46; p=0.007) and alpha 1-antitrypsin and AAA growth (r=0.55; p=0.004).
  
  
  CONCLUSIONS
  Alpha 1-antitrypsin may be a promising biomarker of AAA growth.
authors.affiliation: Department of Angiology and Vascular Surgery, Hospital de Galdakao-Usansolo, Bizkaia, Spain. melina.vegadeceniga@osakidetza.net
authors.forename: M
authors.initials: M
authors.lastname: Vega de Céniga
authors.forename: M
authors.initials: M
authors.lastname: Esteban
authors.forename: J M
authors.initials: JM
authors.lastname: Quintana
authors.forename: A
authors.initials: A
authors.lastname: Barba
authors.forename: L
authors.initials: L
authors.lastname: Estallo
authors.forename: N
authors.initials: N
authors.lastname: de la Fuente
authors.forename: B
authors.initials: B
authors.lastname: Viviens
authors.forename: J L
authors.initials: JL
authors.lastname: Martin-Ventura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000097:blood* / Q000473:pathology*; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010865:Pilot Projects; D000515:alpha 1-Antitrypsin / Q000097:blood*
chemical_list: D015415:Biomarkers; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017270:Lipoprotein(a); D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein