title: Glycaemic profile characteristics and frequency of impaired awareness of hypoglycaemia in subjects with T1D and repeated hypoglycaemic events.
abstract: The aim of our study was to evaluate the frequency of hypoglycaemia unawareness and the continuous glucose profile in a group of subjects with Type 1 diabetes (T1D) with repeated non-severe/severe hypoglycaemia. Twenty patients (aged 35.2 +/- 7.6 years, duration of disease 16.4 +/- 6.4 years) were included. Hypoglycaemia awareness was evaluated using questionnaires and after an acute-induced hypoglycaemia. Glucose profile was studied using 72-h continuous glucose monitoring (CGM). All subjects were classified as having hypoglycaemia unawareness by questionnaires. Four patients displayed a "normal" signs/symptoms response to hypoglycaemia. The CGM revealed 18% of the measurements <70 mg/dl and this percentage was correlated with questionnaire score (r = 0.55, P < 0.035) and with the increase in the percentage of signs/symptoms during the induced hypoglycaemia (r = -0.57, P < 0.015). In patients exhibiting an "abnormal" response during hypoglycaemia, CGM values <70 mg/dl was higher (22.6 +/- 8.4%) than in those with a "normal" response (10.2 +/- 9.0%; P < 0.028). Summarising, in subjects with T1D and repeated hypoglycaemia the frequency of impaired awareness is substantially common. Its presence is related to a high proportion of ambulatory glycaemic profile below the desirable range.
authors.affiliation: Endocrinology and Diabetes Unit, IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer), Hospital Clínic i Universitari, Villarroel 170, 08036, Barcelona, Spain.
authors.forename: Marga
authors.initials: M
authors.lastname: Giménez
authors.forename: Mercè
authors.initials: M
authors.lastname: Lara
authors.forename: Amanda
authors.initials: A
authors.lastname: Jiménez
authors.forename: Ignacio
authors.initials: I
authors.lastname: Conget
mesh_terms: D000328:Adult; D001364:Awareness; D001786:Blood Glucose; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000523:psychology*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000523:psychology*; D008297:Male; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose