title: Validation of an English version of the Padova quality of life instrument to assess quality of life following ileal pouch anal anastomosis.
abstract: OBJECTIVE
  Ileal pouch anal anastomosis (IPAA) is the procedure of choice for most patients requiring surgery for ulcerative colitis and familial adenomatous polyposis because of its perceived improvement in health-related quality of life (HRQL). The aims of this cross-sectional study were to validate an English version of the Padova Inflammatory Bowel Disease Quality of Life questionnaire (PIBDQL) in patients undergoing IPAA and to investigate the pre- and postoperative predictors of long-term HRQL.
  
  
  METHODS
  In May 2005, the English version of the PIBDQL, Short Inflammatory Bowel Disease Questionnaire, and the SF-36 were mailed to 1,379 patients who underwent IPAA at the Mount Sinai Hospital between 1982 and 2004. The test-retest reliability, internal consistency, construct validity, and discriminative ability of the English version of the PIBDQL were assessed.
  
  
  RESULTS
  Nine hundred fifty-five patients (69%) (475 female, 480 male; mean, age 43 years) returned the questionnaires. The mean PIBDQL score was 21.1 (3.4), suggesting good quality of life. Test-retest reliability [intraclass correlation coefficient (ICC) = 0.784] and internal consistency (Cronbach's alpha = 0.83) were good. Construct validity and discriminative ability of the English version of PIBDQL were adequate. Multivariate analysis revealed that women (p < 0.01) and Crohn's disease patients (p < 0.01) had significantly worse PIBDQL scores.
  
  
  CONCLUSIONS
  The English version PIBDQL is a reliable and valid disease-specific instrument for assessing quality of life in patients with IPAA. In this series, female gender and CD were significant predictors of worse HRQL.
authors.affiliation: Department of Surgery, Veneto Oncological Institute (IOV-IRCCS), Padova, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Scarpa
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Victor
authors.forename: Brenda I
authors.initials: BI
authors.lastname: O'Connor
authors.forename: Zane
authors.initials: Z
authors.lastname: Cohen
authors.forename: Robin S
authors.initials: RS
authors.lastname: McLeod
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000523:psychology / Q000601:surgery*; D000328:Adult; D003093:Colitis, Ulcerative / Q000523:psychology / Q000601:surgery*; D039021:Colonic Pouches; D003424:Crohn Disease / Q000523:psychology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011237:Predictive Value of Tests; D016737:Proctocolectomy, Restorative; D011788:Quality of Life; D015203:Reproducibility of Results; D012307:Risk Factors; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult