title: Biodegradable multiblock copolymers based on oligodepsipeptides with shape-memory properties.
abstract: Thermoplastic phase-segregated multiblock copolymers with polydepsipeptides and PCL segments were prepared via coupling of diol and PCL-diol using an aliphatic diisocyanate. The obtained multiblock copolymers showed good elastic properties and a shape memory. Almost complete fixation of the mechanical deformation, resulting in quantitative recovery of the permanent shape with a switching temperature around body temperature, was observed. In hydrolytic degradation experiments, a quick decrease of the molecular weight without induction period was observed, and the material changed from elastic to brittle in 21 d. These materials promise a high potential for biomedical applications such as smart implants or medical devices.
authors.affiliation: Department of Polymer Science and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, China.
authors.forename: Yakai
authors.initials: Y
authors.lastname: Feng
authors.forename: Marc
authors.initials: M
authors.lastname: Behl
authors.forename: Steffen
authors.initials: S
authors.lastname: Kelch
authors.forename: Andreas
authors.initials: A
authors.lastname: Lendlein
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry* / Q000235:genetics; D011108:Polymers / Q000737:chemistry*; D011487:Protein Conformation; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D009842:Oligopeptides; D011108:Polymers