title: Building blocks for the synthesis of post-translationally modified glycated peptides and proteins.
abstract: Growing interest in synthetic peptides carrying post-traslational modifications, in general, and the Amadori modification in particular, raises the need for specific building blocks that can be used in stepwise peptide synthesis. Herein, we report the synthesis of N(alpha)-Fmoc-Lys-OH derivatives containing N(epsilon)-1-deoxyfructopyranosyl moiety.
authors.affiliation: Laboratory of Peptide and Protein Chemistry and Biology, Polo Scientifico e Tecnologico, University of Firenze, Sesto Fiorentino I-50019, Italy.
authors.forename: Stefano
authors.initials: S
authors.lastname: Carganico
authors.forename: Paolo
authors.initials: P
authors.lastname: Rovero
authors.forename: Jose A
authors.initials: JA
authors.lastname: Halperin
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Papini
authors.forename: Michael
authors.initials: M
authors.lastname: Chorev
mesh_terms: D005449:Fluorenes / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011134:Polysaccharides / Q000737:chemistry; D011499:Protein Processing, Post-Translational; D011506:Proteins / Q000138:chemical synthesis / Q000737:chemistry; D011714:Pyrans / Q000737:chemistry
chemical_list: D005449:Fluorenes; D010455:Peptides; D011134:Polysaccharides; D011506:Proteins; D011714:Pyrans