title: [Modified FOLFOX6 was effective for advanced adenocarcinoma with unknown origin in a patient with Crohn's disease].
abstract: A 47-year-old man who was diagnosed as Crohn's disease at the age of 27 became aware of a mass on the forehead. CT and PET scan revealed many scattered tumors in his body. The CEA level was 4424 ng/ml. Primary lesion was not detected by the surveillance of whole gastro-intestinal tract. Liver tumor biopsy samples were histologicaly analyzed and were diagnosed as adenocarcinoma. Further immunohistochemical analysis revealed that the biopsy material had colonic character determined by positive CK20 and negative CK7 staining. Therefore, we performed 12 cycles of mFOLFOX6 chemotherapy. It was effective with the reduced size of tumors and the decreased level of CEA.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine. y.hayashi@gh.med.osaka-u.ac.jp
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nishida
authors.forename: Jumpei
authors.initials: J
authors.lastname: Kondo
authors.forename: Katsumi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Iijima
authors.forename: Shusaku
authors.initials: S
authors.lastname: Tsutsui
authors.forename: Naoki
authors.initials: N
authors.lastname: Hiramatsu
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujii
authors.forename: Shingo
authors.initials: S
authors.lastname: Tsuji
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ito
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Takehara
authors.forename: Norio
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D009944:Organoplatinum Compounds / Q000008:administration & dosage
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil