[Comparison of effectiveness between intra-arterial and intra-venous neoadjuvant chemotherapy in stage Ib2-IIb cervical carcinoma].
OBJECTIVE
To compare the effect between intra-arterial and intra-venous neoadjuvant chemotherapy (NACT) in stage Ib2-IIb cervical carcinoma.


METHODS
A retrospective analysis was done on 52 cases of intra-venous NACT and 95 cases of intra-arterial NACT for stage Ib2-IIb cervical carcinoma treated in Peking Union Medical College Hospital from 1999.


RESULTS
The response rate of intra-venous NACT and intra-arterial NACT was 88% (46/52) and 79% (75/95), and the operative rate after NACT was 81% (42/52) and 72% (68/95) respectively (P > 0.05). There were no significant differences in surgery time, blood loss and post-operative morbidity between these two groups. Pathological parametrial positive rate after NACT in arterial group (6%) was significantly lower than that of venous group (50%, P > 0.05). The venous group had very similar recurrence rates (13% vs 17%) and death rates (9% vs 12%) when compared with the arterial group (P > 0.05).


CONCLUSIONS
The intra-arterial and intra-venous NACT for stage Ib2-IIb cervical carcinoma show similar response rate, operative rate and surgical difficulties. Arterial NACT shows a better effect on parametrial infiltration.
Cao
Dong-yan
DY
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.
Yang
Jia-xin
JX
Shen
Keng
K
Xiang
Yang
Y
Pan
Ling-ya
LY
Lang
Jing-he
JH
Wu
Ming
M
Huang
Hui-fang
HF
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D007262:Infusions, Intravenous; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D011183:Postoperative Complications / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D055815:Young Adult
D002945:Cisplatin; D005472:Fluorouracil