Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports.
BACKGROUND
Chondrosarcomas and chordomas are usually chemoresistant bone tumors and may have a poor prognosis when advanced. They are usually associated with worsening pain difficult to control.


METHODS
Zoledronic acid was used in a 63-year-old man with metastatic chondrosarcoma and in a 66-year-old woman with a diagnosis of sacrum chordoma both reporting severe pain related to tumor.


RESULTS
In the first case, zoledronic acid was able to maintain pain control despite disease progression following chemotherapy, in the other case, zoledronic acid only produced significant clinical benefit.


CONCLUSIONS
Control of pain associated with bone tumors such as chondrosarcoma and chondroma may significantly improve from use of zoledronic acid, independently from tumor response to other treatments. Evaluation on larger series are needed to confirm the clinical effect of this bisphosphonate on such tumors.
Montella
Liliana
L
Medical Oncology Unit San Giovanni di Dio Hospital, 80020 Frattaminore, Naples, Italy. lilianamontella@libero.it
Addeo
Raffaele
R
Faiola
Vincenzo
V
Cennamo
Gregorio
G
Guarrasi
Rosario
R
Capasso
Elena
E
Mamone
Rosanna
R
Caraglia
Michele
M
Del Prete
Salvatore
S
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002812:Chondroma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D002813:Chondrosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012447:Sacrum / Q000000981:diagnostic imaging / Q000473:pathology*; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D000077211:Zoledronic Acid
D000970:Antineoplastic Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid