Pimarane-type diterpenes: antimicrobial activity against oral pathogens.
Seven pimarane type-diterpenes re-isolated from Viguiera arenaria Baker and two semi-synthetic pimarane derivatives were evaluated in vitro against the following main microorganisms responsible for dental caries: Streptococcus salivarius, S. sobrinus, S. mutans, S. mitis, S. sanguinis and Lactobacillus casei. The compounds ent-pimara-8(14),15-dien-19-oic acid (PA); ent-8(14),15-pimaradien-3beta-ol; ent-15-pimarene-8beta,19-diol; ent-8(14),15-pimaradien-3beta-acetoxy and the sodium salt derivative of PA were the most active compounds, displaying MIC values ranging from 2 to 8 microg mL(-1). Thus, this class of compounds seems promising as a class of new effective anticariogenic agents. Furthermore, our results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new natural compounds that could be employed in the development of oral care products.
Porto
Thiago S
TS
Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil.
Rangel
Rander
R
Furtado
Niege A J C
NA
de Carvalho
Tatiane C
TC
Martins
Carlos H G
CH
Veneziani
Rodrigo C S
RC
Da Costa
Fernando B
FB
Vinholis
Adriana H C
AH
Cunha
Wilson R
WR
Heleno
Vladimir C G
VC
Ambrosio
Sergio R
SR
D045784:Abietanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry; D003731:Dental Caries / Q000382:microbiology*; D006801:Humans; D007780:Lacticaseibacillus casei / Q000187:drug effects*; D015394:Molecular Structure; D009055:Mouth / Q000382:microbiology; D013291:Streptococcus / Q000187:drug effects*
D045784:Abietanes; D000900:Anti-Bacterial Agents; C433018:pimarane