title: Role of angiotensin-converting enzyme gene polymorphisms in children with sepsis and septic shock.
abstract: BACKGROUND
  Sepsis is characterized by a systemic inflammatory response. Its development and outcome are associated with host defense, pathogenicity of the microorganism and genetic polymorphisms. Genetic polymorphisms of the immune system genes have been shown to have a close relationship with the clinical outcomes of sepsis. Angiotensin-converting enzyme (ACE) plays a major role in the host defense against invading pathogens. It is therefore likely that polymorphisms in the ACE gene may have an important effect on determining the development and the outcome of sepsis.
  
  
  METHODS
  Ninety-eight children diagnosed as having sepsis and 287 healthy children were included in the study. Insertion/deletion polymorphisms were analyzed using reverse-hybridization assay.
  
  
  RESULTS
  The carriers of I allele (D/I genotype and I/I genotype) were found to have an increased risk of developing sepsis compared to the controls.
  
  
  CONCLUSIONS
  DD genotype may play a positive role against the development of sepsis in healthy children.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey. ozgur.cogulu@ege.edu.tr
authors.forename: Ozgur
authors.initials: O
authors.lastname: Cogulu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Onay
authors.forename: Demet
authors.initials: D
authors.lastname: Uzunkaya
authors.forename: Cumhur
authors.initials: C
authors.lastname: Gunduz
authors.forename: Sacide
authors.initials: S
authors.lastname: Pehlivan
authors.forename: Fadil
authors.initials: F
authors.lastname: Vardar
authors.forename: Fusun
authors.initials: F
authors.lastname: Atlihan
authors.forename: Cihangir
authors.initials: C
authors.lastname: Ozkinay
authors.forename: Ferda
authors.initials: F
authors.lastname: Ozkinay
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D018805:Sepsis / Q000235:genetics*; D012772:Shock, Septic / Q000235:genetics*
chemical_list: D007703:Peptidyl-Dipeptidase A