title: Treatment of severe amitriptyline intoxication with plasmapheresis.
abstract: Tricyclic antidepressant poisoning is one of the most common causes of serious intoxication. Here, we report a 2-year-old girl with severe amitriptyline (70 mg/kg) intoxication. She was in comatose, had generalized tonic clonic seizure, ventricular tachycardia, and wide QRS complexes. Although she did not respond to classical therapies, very good clinical response to plasmapheresis was obtained and she developed no complications. Thus, plasmapheresis may be an effective treatment modality in poisoning with drugs, which bind to plasma proteins with high affinity.
authors.affiliation: Department of Pediatric Neurology, Gazi University, Ankara, Turkey. ebkut@yahoo.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Kolsal
authors.forename: Ishak Ozel
authors.initials: IO
authors.lastname: Tekin
authors.forename: Etem
authors.initials: E
authors.lastname: Piskin
authors.forename: Cumhur
authors.initials: C
authors.lastname: Aydemir
authors.forename: Mehmet
authors.initials: M
authors.lastname: Akyüz
authors.forename: Hasan
authors.initials: H
authors.lastname: Cabuk
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Eldes
authors.forename: Varim
authors.initials: V
authors.lastname: Numanoglu
mesh_terms: D000639:Amitriptyline / Q000506:poisoning*; D002675:Child, Preschool; D003128:Coma; D062787:Drug Overdose / Q000628:therapy*; D005260:Female; D006801:Humans; D010956:Plasmapheresis / Q000379:methods*; D011041:Poisoning / Q000628:therapy; D012640:Seizures; D017180:Tachycardia, Ventricular; D016896:Treatment Outcome
chemical_list: D000639:Amitriptyline