title: The prognostic impact of isolated tumor cells in lymph nodes of T2N0 gastric cancer: comparison of American and Japanese gastric cancer patients.
abstract: BACKGROUND
  The clinical significance of immunohistochemically detected isolated tumor cells (ITC) in lymph nodes of gastric cancer patients is controversial. This study examined the prognostic impact of ITC on patients with early-stage gastric cancer in two large volume centers in the United States and Japan.
  
  
  METHODS
  Fifty-seven patients with T2N0M0 gastric carcinoma who underwent gastric resection between January 1987 and January 1997 at Memorial Sloan-Kettering Cancer Center (MSKCC) in New York and 107 patients resected at National Cancer Center Hospital (NCCH) in Tokyo between January 1984 and December 1990 were studied. The sections were newly prepared from each lymph node for immunohistochemical staining for cytokeratin. Lymph nodes and original specimens from MSKCC were examined by pathologists in NCCH. The prognostic significance of the presence of ITC in lymph nodes was investigated in patients of both institutions.
  
  
  RESULTS
  ITC were identified in 30 of 57 patients (52.6%) at MSKCC and in 38 of 107 patients (35.5%) at NCCH. In both institutions, there was no significant difference in the prognosis of the studied patients with or without ITC (P= .22, .86 respectively).
  
  
  CONCLUSIONS
  The presence of ITC detected by immunohistochemistry in the regional lymph nodes did not affect the prognosis of American and Japanese patients with T2N0M0 gastric carcinoma who underwent gastrectomy with D2 lymph node dissection.
authors.affiliation: Gastric Surgery Division, National Cancer Center Hospital, Tokyo, Japan. tfukagaw@ncc.go.jp
authors.forename: T
authors.initials: T
authors.lastname: Fukagawa
authors.forename: M
authors.initials: M
authors.lastname: Sasako
authors.forename: T
authors.initials: T
authors.lastname: Shimoda
authors.forename: T
authors.initials: T
authors.lastname: Sano
authors.forename: H
authors.initials: H
authors.lastname: Katai
authors.forename: M
authors.initials: M
authors.lastname: Saka
authors.forename: G B
authors.initials: GB
authors.lastname: Mann
authors.forename: M
authors.initials: M
authors.lastname: Karpeh
authors.forename: D G
authors.initials: DG
authors.lastname: Coit
authors.forename: M F
authors.initials: MF
authors.lastname: Brennan
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000556:secondary* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D007124:Immunoenzyme Techniques; D007564:Japan; D007633:Keratins / Q000032:analysis; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating / Q000473:pathology*; D011379:Prognosis; D012307:Risk Factors; D021701:Sentinel Lymph Node Biopsy; D013274:Stomach Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D014481:United States
chemical_list: D014408:Biomarkers, Tumor; D007633:Keratins