Eph receptors in breast cancer: roles in tumor promotion and tumor suppression.
Eph receptor tyrosine kinase signaling regulates cancer initiation and metastatic progression through multiple mechanisms. Studies of tumor-cell-autonomous effects of Eph receptors demonstrate their dual roles in tumor suppression and tumor promotion. In addition, Eph molecules function in the tumor microenvironment, such as in vascular endothelial cells, influencing the ability of these molecules to promote carcinoma progression and metastasis. The complex nature of Eph receptor signaling and crosstalk with other receptor tyrosine kinases presents a unique challenge and an opportunity to develop therapeutic intervention strategies for targeting breast cancer.
Vaught
David
D
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
Brantley-Sieders
Dana M
DM
Chen
Jin
J
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D036081:Receptors, Eph Family / Q000037:antagonists & inhibitors / Q000502:physiology*
D000970:Antineoplastic Agents; D036081:Receptors, Eph Family