title: Rhazinilam and quebrachamine derivatives from Yunnan Kopsia arborea.
abstract: Three new rhazinilam-derived alkaloids, kopsiyunnanines C1, C2, and C3, and a new quebrachamine-type alkaloid, kopsiyunnanine D, which possess an unusual methoxymethyl or ethoxymethyl function, were isolated from the aerial parts of Yunnan Kopsia arborea. This is the first report of the presence of these functions in natural alkaloids. The structures and absolute configurations of the alkaloids were determined by spectroscopic methods and confirmed by semisynthesis.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
authors.forename: Yuqiu
authors.initials: Y
authors.lastname: Wu
authors.forename: Mayu
authors.initials: M
authors.lastname: Suehiro
authors.forename: Mariko
authors.initials: M
authors.lastname: Kitajima
authors.forename: Takeshi
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Shusuke
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Masato
authors.initials: M
authors.lastname: Nagaoka
authors.forename: Rongping
authors.initials: R
authors.lastname: Zhang
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Takayama
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029062:Apocynaceae / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification*; D007212:Indolizines / Q000737:chemistry / Q000302:isolation & purification; D007769:Lactams / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D026121:Indole Alkaloids; D007212:Indolizines; D007769:Lactams; C009170:rhazinilam; C091897:quebrachamine