Circadian rhythm profiles in women with night eating syndrome.
Night eating syndrome (NES) is characterized by evening hyperphagia and frequent awakenings accompanied by food intake. Patients with NES display a delayed circadian pattern of food intake but retain a normal sleep-wake cycle. These characteristics initiated the current study, in which the phase and amplitude of behavioral and neuroendocrine circadian rhythms in patients with NES were evaluated. Fifteen women with NES (mean age +/- SD, 40.8 +/- 8.7 y) and 14 control subjects (38.6 +/- 9.5 y) were studied in the laboratory for 3 nights, with food intake measured daily. Blood also was collected for 25 h (every 2 h from 0800 to 2000 h, and then hourly from 2100 to 0900 h) and assayed for glucose and 7 hormones (insulin, ghrelin, leptin, melatonin, cortisol, thyroid-stimulating hormone [TSH] and prolactin). Statistical analyses utilized linear mixed-effects cosinor analysis. Control subjects displayed normal phases and amplitudes for all circadian rhythms. In contrast, patients with NES showed a phase delay in the timing of meals, and delayed circadian rhythms for total caloric, fat, and carbohydrate intake. In addition, phase delays of 1.0 to 2.8 h were found in 2 food-regulatory rhythms-leptin and insulin-and in the circadian melatonin rhythm (with a trend for a delay in the circadian cortisol rhythm). In contrast, circulating levels of ghrelin, the primary hormone that stimulates food intake, were phase advanced by 5.2 h. The glucose rhythm showed an inverted circadian pattern. Patients with NES also showed reduced amplitudes in the circadian rhythms of food intake, cortisol, ghrelin, and insulin, but increased TSH amplitude. Thus, patients with NES demonstrated significant changes in the timing and amplitude of various behavioral and physiological circadian markers involved in appetite and neuroendocrine regulation. As such, NES may result from dissociations between central (suprachiasmatic nucleus) timing mechanisms and putative oscillators elsewhere in the central nervous system or periphery, such as the stomach or liver. Considering these results, chronobiologic treatments for NES such as bright light therapy may be useful. Indeed, bright light therapy has shown efficacy in reducing night eating in case studies and should be evaluated in controlled clinical trials.
Goel
Namni
N
University of Pennsylvania School of Medicine, Philadelphia, PA, USA. goel@mail.med.upenn.edu
Stunkard
Albert J
AJ
Rogers
Naomi L
NL
Van Dongen
Hans P A
HP
Allison
Kelly C
KC
O'Reardon
John P
JP
Ahima
Rexford S
RS
Cummings
David E
DE
Heo
Moonseong
M
Dinges
David F
DF
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D002940:Circadian Rhythm; D004435:Eating; D005247:Feeding Behavior; D001068:Feeding and Eating Disorders / Q000097:blood / Q000175:diagnosis; D005260:Female; D006801:Humans; D006963:Hyperphagia / Q000097:blood / Q000175:diagnosis; D008875:Middle Aged; D015203:Reproducibility of Results; D007319:Sleep Initiation and Maintenance Disorders / Q000097:blood / Q000503:physiopathology; D013577:Syndrome