Genetic analysis of ESCRT function in Drosophila: a tumour model for human Tsg101.
Class E Vps (vacuolar protein sorting) proteins are components of the ESCRTs (endosomal sorting complexes required for transport) which are required for protein sorting at the early endosome. Most of these genes have been identified and genetically characterized in yeast. Recent genetic studies in Drosophila have revealed the phenotypic consequences of loss of vps function in multicellular organisms. In the present paper, we review these studies and discuss a mechanism which may explain how loss of the human Tsg101 (tumour susceptibility gene 101), a vps23 orthologue, causes tumours.
Herz
Hans-Martin
HM
MD Anderson Cancer Center, Department of Biochemistry and Molecular Biology, Genes and Development Graduate Program, 1515 Holcombe Boulevard, Unit 1000, Houston, TX 77030, USA.
Bergmann
Andreas
A
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000235:genetics*; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D046912:Multiprotein Complexes / Q000235:genetics*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics* / Q000473:pathology; D021381:Protein Transport; D014157:Transcription Factors / Q000378:metabolism*; D000099177:Tsg101 Protein
D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D046912:Multiprotein Complexes; D014157:Transcription Factors; D000099177:Tsg101 Protein