Targeted delivery of radioprotective agents to mitochondria.
Adverse effects of ionizing radiation are mediated through reactive oxygen and nitrogen species. Mitochondria are the principal source of these species in the cell and play an important role in irradiation-induced apoptosis. The use of free radical scavengers and nitric oxide synthase inhibitors has proven to protect normal tissues and, in some cases, to sensitize tumor tissues to radiation damage. Dual molecules that combine radical-scavenging and NOS-inhibitory functions may be particularly effective. Drugging strategies that target mitochondria can enhance the effectiveness of such agents, in comparison to systemic administration, and circumvent side effects.
Zabbarova
Irina
I
Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
Kanai
Anthony
A
D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000528:radiation effects*; D009369:Neoplasms / Q000188:drug therapy; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000627:therapeutic use
D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents