title: Collagen VI protects neurons against Abeta toxicity.
abstract: Amyloid-beta (Abeta) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented Abeta neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of Abeta oligomers with neurons, enhanced Abeta aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.
authors.affiliation: Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, California 94158, USA.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Cheng
authors.forename: Dena B
authors.initials: DB
authors.lastname: Dubal
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Kim
authors.forename: Justin
authors.initials: J
authors.lastname: Legleiter
authors.forename: Irene H
authors.initials: IH
authors.lastname: Cheng
authors.forename: Gui-Qiu
authors.initials: GQ
authors.lastname: Yu
authors.forename: Ina
authors.initials: I
authors.lastname: Tesseur
authors.forename: Tony
authors.initials: T
authors.lastname: Wyss-Coray
authors.forename: Paolo
authors.initials: P
authors.lastname: Bonaldo
authors.forename: Lennart
authors.initials: L
authors.lastname: Mucke
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D024142:Collagen Type VI / Q000235:genetics / Q000378:metabolism*; D018891:Dentate Gyrus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D024142:Collagen Type VI; D010446:Peptide Fragments; D016212:Transforming Growth Factor beta; C075222:amyloid beta-protein (1-42)