title: The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.
abstract: The synthesis of 2',2'-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
authors.affiliation: School of Chemistry, University of Southampton Highfield, Southampton SO17 1BJ, UK.
authors.forename: Leo
authors.initials: L
authors.lastname: Leung
authors.forename: Cyrille
authors.initials: C
authors.lastname: Tomassi
authors.forename: Katrien
authors.initials: K
authors.lastname: Van Beneden
authors.forename: Tine
authors.initials: T
authors.lastname: Decruy
authors.forename: Matthias
authors.initials: M
authors.lastname: Trappeniers
authors.forename: Dirk
authors.initials: D
authors.lastname: Elewaut
authors.forename: Yifang
authors.initials: Y
authors.lastname: Gao
authors.forename: Tim
authors.initials: T
authors.lastname: Elliott
authors.forename: Aymen
authors.initials: A
authors.lastname: Al-Shamkhani
authors.forename: Christian
authors.initials: C
authors.lastname: Ottensmeier
authors.forename: Jörn M
authors.initials: JM
authors.lastname: Werner
authors.forename: Anthony
authors.initials: A
authors.lastname: Williams
authors.forename: Serge
authors.initials: S
authors.lastname: Van Calenbergh
authors.forename: Bruno
authors.initials: B
authors.lastname: Linclau
mesh_terms: D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D055611:Natural Killer T-Cells; D055607:Receptors, Natural Killer Cell / Q000276:immunology
chemical_list: C541342:2',2'-difluoro KRN7000; D018949:Antigens, CD1; D016207:Cytokines; D005699:Galactosylceramides; D055607:Receptors, Natural Killer Cell