Tuberculous meningitis in HIV-infected and non-infected patients: comparison of cerebrospinal fluid findings.
We performed a retrospective comparison of cerebrospinal fluid (CSF) characteristics and drug susceptibility profile in human immunodeficiency virus (HIV) infected and non-infected patients with a diagnosis of tuberculous meningitis. HIV-infected patients had a higher frequency of non-inflammatory CSF (absence of pleocytosis) and of infection by multidrug-resistant strains of Mycobacterium tuberculosis. Protein CSF levels were lower in HIV-infected patients, while and glucose concentration was similar in both groups. Hospital mortality was significantly higher in HIV-infected patients (63.3% [64/101] vs. 17.5% [7/40]).
Cecchini
D
D
Hospital Francisco J Muñiz, Buenos Aires, Argentina. diegocec@gmail.com
Ambrosioni
J
J
Brezzo
C
C
Corti
M
M
Rybko
A
A
Perez
M
M
Poggi
S
S
Ambroggi
M
M
D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D002555:Cerebrospinal Fluid / Q000737:chemistry / Q000166:cytology / Q000382:microbiology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D024901:Drug Resistance, Multiple, Bacterial; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use; D005260:Female; D005947:Glucose / Q000134:cerebrospinal fluid; D015658:HIV Infections / Q000134:cerebrospinal fluid* / Q000150:complications*; D017052:Hospital Mortality; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D007958:Leukocyte Count; D008297:Male; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis; D011718:Pyrazinamide / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome; D014390:Tuberculosis, Meningeal / Q000134:cerebrospinal fluid* / Q000150:complications* / Q000188:drug therapy; D055815:Young Adult
D000995:Antitubercular Agents; D002556:Cerebrospinal Fluid Proteins; D011718:Pyrazinamide; D004977:Ethambutol; D005947:Glucose; D007538:Isoniazid