title: C Reactive protein and disease severity in bronchiolitis.
abstract: A diagnosis of bronchiolitis is made clinically and the use of supportive laboratory examinations, including the quantification of C reactive protein (CRP), is not well established. The aim of this study was to evaluate the correlation between CRP value and indirect markers of disease severity in patients with bronchiolitis. This study included the patients diagnosed with bronchiolitis admitted to the Pediatrics Department of S. João Hospital in 2006. A retrospective review was made through analysing clinical files. 176 patients aged 0 to 36 months (median of 4 months) were included. 63.1% were males. CRP level was measured in 94.3% of the patients, with va- lues ranging from zero to 256 mg/L and a median of 11 mg/L. CRP value in this population had a statistically significant relation with admission to Intensive Care Unit (ICU) (p=0.008), length of hospital stay (p=0.025) and need for supplementary oxygen during hospital stay (p=0.022). This work raises the hypothesis that the CRP value on admission might be a marker of disease severity and have prognostic significance in patients with bronchiolitis. Further investigation is necessary to validate these results and exclude the potential confounding effect of associated infections.
authors.affiliation: Paediatrics Department, Hospital S. João. sdrmcosta@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Costa
authors.forename: R
authors.initials: R
authors.lastname: Rocha
authors.forename: M
authors.initials: M
authors.lastname: Tavares
authors.forename: A
authors.initials: A
authors.lastname: Bonito-Vítor
authors.forename: L
authors.initials: L
authors.lastname: Guedes-Vaz
mesh_terms: D015415:Biomarkers / Q000097:blood; D001988:Bronchiolitis / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein