title: Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds.
abstract: In a search for potential cancer chemopreventive agents from natural resources, stevioside (1), a sweetener, and six related compounds, including two aglycones steviol (6) and isosteviol (7), were screened in an in vitro assay for inhibitory effects on Epstein-Barr virus early antigen activation. Compounds 1, 6 and 7 showed significant activity in this assay and also exhibited strong inhibitory effects in a two-stage carcinogenesis test using mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). The inhibitory effects of these three compounds were greater than that of glycyrrhizin. Furthermore, these three compounds significantly inhibited mouse skin carcinogenesis initiated by peroxynitrite and promoted by TPA. Their activities were comparable to that of curcumin. These results suggested that 1, as well as 6 and 7, could be valuable as chemopreventive agents for chemical carcinogenesis.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.
authors.forename: Midori
authors.initials: M
authors.lastname: Takasaki
authors.forename: Takao
authors.initials: T
authors.lastname: Konoshima
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Kozuka
authors.forename: Harukuni
authors.initials: H
authors.lastname: Tokuda
authors.forename: Junko
authors.initials: J
authors.lastname: Takayasu
authors.forename: Hoyoku
authors.initials: H
authors.lastname: Nishino
authors.forename: Masazumi
authors.initials: M
authors.lastname: Miyakoshi
authors.forename: Kenji
authors.initials: K
authors.lastname: Mizutani
authors.forename: Kuo-Hsiung
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D015197:Carcinogenicity Tests; D018890:Chemoprevention / Q000379:methods; D003474:Curcumin; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D019695:Glycyrrhizic Acid; D004854:Herpesvirus 4, Human / Q000187:drug effects; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D000970:Antineoplastic Agents; D045786:Diterpenes, Kaurane; D005960:Glucosides; C515747:isosteviol; C012043:stevioside; C012042:steviol; D019695:Glycyrrhizic Acid; D003474:Curcumin