Future risk of diabetes in mother and child after gestational diabetes mellitus.
Gestational diabetes mellitus (GDM) is a common pregnancy complication with increased maternal and perinatal morbidity. However, significant long-term morbidity also exists for the mother and offspring. Women with previous GDM have a very high risk of developing overt diabetes, primarily type 2 diabetes, later in life. Moreover, the risk of the metabolic syndrome is increased 3-fold in these women. Their offspring have an 8-fold risk of diabetes/prediabetes at 19-27 years of age. Thus, GDM is part of a vicious circle which increases the development of diabetes in the coming generations.
Damm
Peter
P
Center for Pregnant Women with Diabetes, Department of Obstetrics and Endocrinology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. pdamm@dadlnet.dk
D000328:Adult; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000209:etiology*; D016640:Diabetes, Gestational / Q000453:epidemiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000209:etiology; D011236:Prediabetic State / Q000453:epidemiology / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D012307:Risk Factors; D055815:Young Adult