HIV infection of the genital mucosa in women.
The vast majority of new HIV infections are acquired via the genital and rectal mucosa. Here, we provide an overview of our current knowledge of how HIV establishes local infection, with an emphasis on viral invasion through the female genital tract. Studies using human explant tissues and in vivo animal studies have improved our understanding of the cellular and molecular pathways of infection; this information could be harnessed to design effective HIV vaccines and microbicides.
Hladik
Florian
F
Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, D3-100, Seattle, WA 98109-1024, USA. fhladik@fhcrc.org
Hope
Thomas J
TJ
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002584:Cervix Uteri / Q000166:cytology / Q000276:immunology / Q000821:virology; D018450:Disease Progression; D005260:Female; D005836:Genitalia, Female / Q000166:cytology / Q000276:immunology / Q000821:virology*; D015658:HIV Infections / Q000276:immunology / Q000635:transmission / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D009092:Mucous Membrane / Q000276:immunology / Q000821:virology*; D015229:Sexually Transmitted Diseases, Viral / Q000276:immunology / Q000635:transmission / Q000821:virology; D014621:Vagina / Q000166:cytology / Q000276:immunology / Q000821:virology