Models for chromosomal replication-independent non-B DNA structure-induced genetic instability.
Regions of genomic DNA containing repetitive nucleotide sequences can adopt a number of different structures in addition to the canonical B-DNA form: many of these non-B DNA structures are causative factors in genetic instability and human disease. Although chromosomal DNA replication through such repetitive sequences has been considered a major cause of non-B form DNA structure-induced genetic instability, it is also observed in non-proliferative tissues. In this review, we discuss putative mechanisms responsible for the mutagenesis induced by non-B DNA structures in the absence of chromosomal DNA replication.
Wang
Guliang
G
Department of Carcinogenesis, University of Texas M.D. Anderson Cancer Center, Science Park-Research Division, 1808 Park Road 1-C, Smithville, TX 78957, USA.
Vasquez
Karen M
KM
D000818:Animals; D002869:Chromosome Aberrations; D004247:DNA / Q000235:genetics*; D004261:DNA Replication; D042822:Genomic Instability; D006801:Humans; D008957:Models, Genetic; D009690:Nucleic Acid Conformation
D004247:DNA