Preparation and characterization of mucinated cellulose microparticles for therapeutic and drug delivery purposes.
Mucinated cellulose microparticles were generated by mixing equal concentrations of colloidal dispersions of porcine mucin (Mc) and microcrystalline cellulose (MCC). The hybrid polymer was recovered by precipitating at controlled temperature and pH conditions using acetone. Some physicochemical, functional and thermal properties of the hybrid polymer were determined and compared with those of Mc and MCC. The new polymer Mc-MCC had swelling and moisture sorption profiles that were different from those of Mc and MCC in buffer solutions with different pH values and relative humidity, respectively. The mucoadhesive property of the new polymer was similar to that of Mc. The scanning electron micrographs (SEMs) showed that the microparticles generated from the hybridization were similar to those of MCC, but with larger and denser particles. The Fourier Transform Infrared (FT-IR) spectrum and Differential Scanning Calorimeter (DSC) thermogram of the hybrid polymer were characteristically different from those of Mc and MCC. The presence of new peaks in the FT-IR spectrum and distinct cold crystallization exotherm, which were absent in both Mc and MCC, confirms the formation of a new polymer type with synergistic physicochemical and functional properties.
Builders
Philip F
PF
Department of Pharmaceutical Technology and Raw Materials Development, National Institute for Pharmaceutical Research and Development, Abuja, Nigeria. philsonsky@yahoo.com
Ibekwe
Nneka
N
Okpako
Larry C
LC
Attama
Anthony A
AA
Kunle
Olobayo O
OO
D000096:Acetone / Q000737:chemistry; D000327:Adsorption; D002021:Buffers; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002448:Cell Adhesion; D002482:Cellulose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008863:Microspheres; D011108:Polymers / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013997:Time Factors
D002021:Buffers; D011108:Polymers; D000096:Acetone; D002482:Cellulose; C109691:microcrystalline cellulose