[Effect of hydrochloric acid on cavernous pressure in the duodenogastroesphageal zone in patients with duodenal ulcer associated with Helicobacter pylori].
Endoscopic manometrografy was performed in 128 patients 40,7 +/- 1,7 years old with duodenal ulcer (DU). In patients with increased basal acid outflow (BAO > 10 MM/per hour vs. BAO < 7 MM/per hour) was increased pressure (mm Hg) in duodenum (11,8 +/- 1,0 vs. 9,2 +/- 0,5) and gastric antrum (11,4 +/- 0,6 vs. 9,3 +/- 0,4), decreased pylorus tone (18,5 +/- 2,4 vs. 30,6 +/- 2,2) and pressure gradient (deltaP) between low esophageal sphincter (LES) and duodenum (3,9 +/- 1,3 vs. 6,4 +/- 0,3). Acid infusion of duodenum with 0.1N HCL in 39 patients with DU was accompanied with the sensation of pain in 87,2% patients with active duodenal ulcers and increased pressure in duodenum (from 9,7 +/- 1,1 to 13,1 +/- 1,2) and gastric antrum (from 8,6 +/- 1,3 to 12,8 +/- 1,4). In 47 Hp-positive patients versus 26 Hp-negative patients was detected increased deltaP duodenum-gastric antrum (2,1 +/- 1,1 vs.- 0,6 +/- 0,43), decreased deltaP LES-duodenum (3,4 +/- 1,5 vs. 8,3 +/- 1,6), deltaP LES-gastric body (9,8 +/- 1,2 vs. 14,3 +/- 1,3) and significantly esophagitis (0,64 +/- 0,09 vs. 0,38 +/- 0,11 score, p < 0,05).
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D000328:Adult; D004381:Duodenal Ulcer / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D004386:Duodenum / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D016145:Endoscopy, Digestive System; D004947:Esophagus / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism; D016481:Helicobacter Infections / Q000378:metabolism / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011312:Pressure; D013270:Stomach / Q000382:microbiology / Q000503:physiopathology*; D055815:Young Adult