[Hyperthyroidism during pregnancy: maternal-fetal outcomes].
OBJECTIVE
to evaluate the experience of Hospital das Clínicas da Faculdade de Medicina de Botucatu da Universidade Estadual Paulista 'Júlio de Mesquita Filho', in the follow-up of pregnant women with hyperthyroidism.


METHODS
Sixty patients, divided in groups with compensated hyperthyroidism (CHG=24) and with uncompensated hyperthyroidism (UHG=36) were retrospectively studied and compared concerning clinical-laboratorial characteristics and intercurrences. The t-Student test, contingency tables, multiple linear regression and multiple logistic regression with significance level at 5.0% were used.


RESULTS
propylthiouracil (PTU) was used by 94.0% of UHG and by 42.0% of CHG (p<0.0001); maternal complications close to delivery have occurred in 20.6% of UHG and in 11.8% of CHG, and UHG presented three fetal deaths, influenced by the mother age, higher level of T4L (lT4L) and of PTU dose (PTUd) in the third trimester (p=0.007); restriction of intra-uterine growth, influenced by lT4L and PTUd in the third trimester has occurred in nine UHG and in three CHG cases, and oligoamnios has occurred in 12 patients (83.3% of UGH and 16.7% of CGH), influenced by age and lT4L in the third trimester (p=0.04); the gestational age at delivery was 34.4+/-4.6 weeks in UHG and 37.0+/-2.5 in CHG, influenced by the T4Ll in the third trimester (p<0.05).


CONCLUSIONS
the UHG has presented less satisfactory results than CHG, influenced by high lT4L and PTUd in the third trimester, and by more advanced age of some pregnant women.
Pinheiro
Amanda Tavares
AT
Departamento de Pediatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, Botucatu, SP, Brasil.
Costa
Roberto Antonio Araújo
RA
Abbade
Joelcio Francisco
JF
Magalhães
Cláudia Garcia
CG
Mazeto
Gláucia Maria Ferreira da Silva
GM
D000328:Adult; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology; D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000453:epidemiology; D011256:Pregnancy Outcome; D012189:Retrospective Studies