Prodrug designing of NSAIDs.
Non-steroidal anti-inflammatory drugs (NSAIDs), commonly used for the treatment of chronic inflammatory diseases suffer from several undesired side effects, the most important being gastrointestinal (GI) irritation and ulceration. The prodrug designing is one of the several strategies used to overcome this drawback. The rationale behind the prodrug concept is to achieve temporary blockade of the free carboxylic group present in the NSAIDs till their systemic absorption. In this paper, a review on the concept of prodrugs designing of NSAIDs to improve their efficacy and reduce the toxicity is being presented.
Halen
Parmeshwari K
PK
Pharmacy Department, Faculty of Tech. & Engg., Kalabhavan, P. B. No. 51, The M.S.University of Baroda, Vadodara- 390001, India.
Murumkar
Prashant R
PR
Giridhar
Rajani
R
Yadav
Mange Ram
MR
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D006016:Glycolates / Q000737:chemistry / Q000494:pharmacology; D007052:Ibuprofen / Q000737:chemistry / Q000494:pharmacology; D009609:Nitrous Oxide / Q000737:chemistry / Q000378:metabolism; D011355:Prodrugs / Q000737:chemistry* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D006016:Glycolates; D011355:Prodrugs; C053956:glycolamide; D009609:Nitrous Oxide; D007052:Ibuprofen