[An association between glucose metabolism status and brachial-ankle pulse wave velocity in Chinese patients with coronary artery disease].
OBJECTIVE
To investigate the association between glucose metabolism status and brachial-ankle pulse wave velocity (baPWV) in Chinese patients with coronary artery disease (CAD).


METHODS
baPWV values were measured in 198 CAD patients. Plasma glucose, serum lipids, hsCRP and other baseline data were obtained in all the patients. According to the glucose level, the participants were divided into 3 groups: normal glucose tolerance (NGT) group, impaired glucose regulation (IGR) group and diabetes mellitus (DM) group.


RESULTS
baPWV values in the DM group (1807 +/- 381) cm/s were significantly higher than those in the NGT group [(1615 +/- 248) cm/s, P = 0.000] and IGR group [(1674 +/- 277) cm/s, P = 0.035]. Multiple stepwise linear regression analyses indicated that higher baPWV values were associated with aging and hsCRP levels in 198 patients. In DM group, higher baPWV values were independently associated with aging and HbA1c levels.


CONCLUSIONS
In patients with coronary artery disease, baPWV values increase with different glucose metabolism status from NGT to IGR then DM. baPWV values in the patients with DM were significantly higher than those in the other two groups. Glycemic control may ameliorate arterial stiffness.
Shen
Jia-jia
JJ
Department of Cardiology, Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, China.
Wu
Yong-quan
YQ
Li
Jue
J
Hu
Da-yi
DY
D000368:Aged; D055109:Ankle Brachial Index; D001783:Blood Flow Velocity; D001786:Blood Glucose / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D001786:Blood Glucose