Assembly of environmental sensitive microcapsules of PNIPAAm and alginate acid and their application in drug release.
The objective of this research was to fabricate stable and environmentally sensitive (PNIPAAm/ALG)(n) microcapsules via layer-by-layer (LbL) technique. The structure, thermosensitive and pH-sensitive properties of the microcapsules were characterized by transmission electron microscopy (TEM), confocal laser scanning microscopy (CLSM) and atomic force microscopy (AFM), individually. MnCO(3) microparticles and melamine formaldehyde (MF) microparticles were used as templates separately. The microcapsules from MnCO(3) cores were stable over a large pH range with thermosensitive and pH-sensitive properties, while those from MF particles were unstable in basic solutions. To the end, ALG and PNIPAAm were adsorbed on recrystallized taxol alternatively, which obviously prolonged the release time of taxol above lower crystal solution temperature (LCST) of PNIPAAm.
Wang
Anhe
A
Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing 100190, PR China.
Tao
Cheng
C
Cui
Yue
Y
Duan
Li
L
Yang
Yang
Y
Li
Junbai
J
D000178:Acrylamides; D000180:Acrylic Resins; D000464:Alginates; D002214:Capsules / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry*; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D006863:Hydrogen-Ion Concentration; D008853:Microscopy; D017239:Paclitaxel / Q000008:administration & dosage; D011108:Polymers; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D000464:Alginates; D002214:Capsules; D003692:Delayed-Action Preparations; D006603:Hexuronic Acids; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D020723:Glucuronic Acid; D017239:Paclitaxel