Area-specific representation of mechanical nociceptive stimuli within SI cortex of squirrel monkeys.
While functional imaging studies in humans have consistently reported activation of primary somatosensory cortex (SI) with painful stimuli, the specific roles of subdivisions of areas 3a, 3b, and 1 within SI during pain perception are largely unknown, particularly in the representation of mechanical evoked pain. In this study, we investigated how modality, location, and intensity of nociceptive stimuli are represented within SI by using high-spatial resolution optical imaging of intrinsic signals in Pentothal-anesthetized squirrel monkeys. Perceptually comparable mechanical nociceptive and innocuous tactile stimuli were delivered by indenting the glabrous skin of the distal finger pads with 0.2 and 2mm diameter probes, respectively. Within each of areas 3a, 3b, and 1, activations to mechanical nociceptive stimulation of individual distal finger pads were spatially distinct and somatotopically organized. We observed differential cortical activation patterns. Areas 3a, 3b, and 1 were all activated during mechanical nociceptive stimulation and were modulated by nociceptive stimulus intensity. However, with innocuous tactile stimulation, mainly areas 3b and 1 exhibited response modulation with different levels of stimulation. In summary, mechanical nociceptive inputs are area-specific and topographically represented within SI. We propose that all areas of SI are implicated in encoding the features of mechanical nociception, where areas 3a and 3b are distinctively involved in coding nociceptive and pressure sensation components of stimulation.
Chen
Li Min
LM
Department of Radiology and Radiological Science, Vanderbilt University, Nashville, TN 37232, USA Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232, USA Department of Psychology, Vanderbilt University, Nashville, TN 37203, USA.
Friedman
Robert M
RM
Roe
Anna Wang
AW
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001931:Brain Mapping; D003952:Diagnostic Imaging / Q000379:methods; D005385:Fingers / Q000294:innervation; D006801:Humans; D006930:Hyperalgesia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D017288:Pain Threshold / Q000502:physiology*; D010812:Physical Stimulation / Q000009:adverse effects*; D011601:Psychophysics; D012453:Saimiri; D013003:Somatosensory Cortex / Q000473:pathology / Q000503:physiopathology*