title: Identification of quantitative trait loci for locomotor  activation and anxiety using closely related inbred  strains.
abstract: We carried out a quantitative trait loci (QTL) mapping experiment in two phenotypically similar inbred mouse strains, C57BL/6J and C58/J, using the open-field assay, a well-established model of anxiety-related behavior in rodents. This intercross was initially carried out as a control cross for an ethylnitrosurea mutagenesis mapping study. Surprisingly, although open-field behavior is similar in the two strains, we identified significant QTL in their F2 progeny. Marker regression identified a locus on Chr 8 having associations with multiple open-field measures and a significant interaction between loci on Chr 13 and 17. Together, the Chr 8 locus and the interaction effect form the core set of QTL controlling these behaviors with additional loci on Chr 1 and 6 present in a subset of the behaviors.
authors.affiliation: Genomics Institute of the Novartis Research Foundation, Department of Genetics, San Diego, CA, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Bailey
authors.forename: L
authors.initials: L
authors.lastname: Grabowski-Boase
authors.forename: B M
authors.initials: BM
authors.lastname: Steffy
authors.forename: T
authors.initials: T
authors.lastname: Wiltshire
authors.forename: G A
authors.initials: GA
authors.lastname: Churchill
authors.forename: L M
authors.initials: LM
authors.lastname: Tarantino
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics* / Q000523:psychology; D002874:Chromosome Mapping; D005038:Ethylnitrosourea; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000235:genetics*; D009153:Mutagens; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis
chemical_list: D009153:Mutagens; D005038:Ethylnitrosourea