Collagen VI protects neurons against Abeta toxicity.
Amyloid-beta (Abeta) peptides, widely presumed to cause Alzheimer's disease, increased mouse neuronal expression of collagen VI through a mechanism involving transforming growth factor signaling. Reduction of collagen VI augmented Abeta neurotoxicity, whereas treatment of neurons with soluble collagen VI blocked the association of Abeta oligomers with neurons, enhanced Abeta aggregation and prevented neurotoxicity. These results identify collagen VI as an important component of the neuronal injury response and demonstrate its neuroprotective potential.
Cheng
Jason S
JS
Gladstone Institute of Neurological Disease, 1650 Owens Street, San Francisco, California 94158, USA.
Dubal
Dena B
DB
Kim
Daniel H
DH
Legleiter
Justin
J
Cheng
Irene H
IH
Yu
Gui-Qiu
GQ
Tesseur
Ina
I
Wyss-Coray
Tony
T
Bonaldo
Paolo
P
Mucke
Lennart
L
D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology* / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000378:metabolism; D024142:Collagen Type VI / Q000235:genetics / Q000378:metabolism*; D018891:Dentate Gyrus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D020411:Oligonucleotide Array Sequence Analysis; D010446:Peptide Fragments / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000378:metabolism
D016229:Amyloid beta-Peptides; D024142:Collagen Type VI; D010446:Peptide Fragments; D016212:Transforming Growth Factor beta; C075222:amyloid beta-protein (1-42)