miRNA regulation of cytokine genes.
In this review we discuss specific examples of regulation of cytokine genes and focus on a new mechanism involving post-transcriptional regulation via miRNAs. The post-transcriptional regulation of cytokine genes via the destabilizing activity of AU-rich elements [AREs] and miRNAs is a pre-requisite for regulating the half-life of many cytokines and achieving the temporal and spatial distributions required for regulation of these genes.
Asirvatham
Ananthi J
AJ
Roswell Park Cancer Institute, Laboratory of Molecular Medicine, Department of Immunology, Elm & Carlton Streets, Buffalo, NY 14263, USA.
Magner
William J
WJ
Tomasi
Thomas B
TB
D000818:Animals; D016207:Cytokines / Q000235:genetics* / Q000378:metabolism; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D007249:Inflammation / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional; D014157:Transcription Factors / Q000378:metabolism
D016207:Cytokines; D035683:MicroRNAs; D014157:Transcription Factors