title: Polycations. 18. The synthesis of polycationic lipid materials based on the diamine 1,4-diazabicyclo[2.2.2]octane.
abstract: Herein is reported the preparation of several series of polyammonium salts that serve as cationic lipids or precursors thereof, and are structurally based on the parent diamine 1,4-diazabicyclo[2.2.2]octane (dabco). Through selective alkylation of dabco a variety of di- and tetracationic lipid species and precursors thereof have been prepared. The resultant materials are of significant interest for a variety of purposes, including serving as antimicrobial agents and antihydrophobic species, the details of which are provided in separate reports.
authors.affiliation: Department of Chemistry and Biochemistry, Queens College of CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA. robert.engel@qc.cuny.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Engel
authors.forename: Jaimelee Iolani
authors.initials: JI
authors.lastname: Rizzo
authors.forename: Christina
authors.initials: C
authors.lastname: Rivera
authors.forename: Mariah
authors.initials: M
authors.lastname: Ramirez
authors.forename: Mia Lace
authors.initials: ML
authors.lastname: Huang
authors.forename: Diego
authors.initials: D
authors.lastname: Montenegro
authors.forename: Craig
authors.initials: C
authors.lastname: Copodiferro
authors.forename: Valbona
authors.initials: V
authors.lastname: Behaj
authors.forename: Marie
authors.initials: M
authors.lastname: Thomas
authors.forename: Barbara
authors.initials: B
authors.lastname: Klaritch-vrana
authors.forename: Jeanne Fabian
authors.initials: JF
authors.lastname: Engel
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003959:Diamines / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D000071228:Polyelectrolytes
chemical_list: D000890:Anti-Infective Agents; D003959:Diamines; D008055:Lipids; D010879:Piperazines; D011073:Polyamines; D000071228:Polyelectrolytes; C007306:triethylenediamine