title: Gingival hypertrophy: a solitary manifestation of scurvy.
abstract: A 48-year-old woman presented with rapid onset hypertrophy of both the upper and lower gingiva. A detailed history and a diet nearly void of fruits and vegetables raised the suspicion of a possible deficiency of vitamin C. An estimation of the serum ascorbic acid level confirmed our suspicions (<0.12 mg/dL; normal range, 0.4-1.0 mg/dL) and a diagnosis of scurvy was confirmed. A course of 1000 mg/d of ascorbic acid was initiated that caused a dramatic resolution of the gingival lesions. Gingival hypertrophy has a large differential diagnosis; however, it is also known to be an extremely rare manifestation of scurvy. A high index of suspicion for scurvy is relevant given its low prevalence in developed nations and how easily remediable the disease can be, even when it presents in a severe form.
authors.affiliation: Department of Otolaryngology and Head Neck Surgery, University of Pittsburgh, Pittsburgh, PA 15213, USA.
authors.forename: Ryan
authors.initials: R
authors.lastname: Li
authors.forename: Karin
authors.initials: K
authors.lastname: Byers
authors.forename: Rohan R
authors.initials: RR
authors.lastname: Walvekar
mesh_terms: D001205:Ascorbic Acid / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005882:Gingival Diseases / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy / Q000473:pathology; D008875:Middle Aged; D018570:Risk Assessment; D012614:Scurvy / Q000150:complications* / Q000175:diagnosis; D016896:Treatment Outcome
chemical_list: D001205:Ascorbic Acid