title: New conjugates of superoxide dismutase/catalase mimetics with cyclodestrins.
abstract: Mimetics of antioxidant enzymes such as superoxide dismutases (SOD) or catalases are reported as potential new drugs able to reduce oxidative stress damage. In particular, manganese(III) complexes of salen-type ligands have been studied as both SOD and catalase mimetics. In this paper, we report the synthesis of two novel conjugates of salen-type ligands with the beta-cyclodextrin, the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(salicylidene))]-beta-cyclodextrin and the 6-deoxy-6-[(S-cysteamidopropyl(1,2-diamino)N,N'-bis(3-methoxysalicylidene))]-beta-cyclodextrin, their spectroscopic characterization, and the synthesis and the characterization of their manganese(III) complexes. The SOD-like activity of the metal complexes was investigated by the indirect Fridovich method. The catalase like activity was tested using a Clark-type oxygen electrode. The peroxidase activity was tested using the ABTS (2,2'-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid)) assay. The glycoconjugation of salen-manganese(III) complexes yields compounds with enhanced SOD activity. These complexes also show catalase and peroxidase activities higher than the simple salen complexes (EUK 113 and EUK 108).
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, viale A. Doria 8, 95125 Catania, Italy.
authors.forename: Valeria
authors.initials: V
authors.lastname: Lanza
authors.forename: Graziella
authors.initials: G
authors.lastname: Vecchio
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry*; D002374:Catalase / Q000138:chemical synthesis / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry*; D018384:Oxidative Stress; D009195:Peroxidase / Q000138:chemical synthesis / Q000737:chemistry; D013482:Superoxide Dismutase / Q000138:chemical synthesis / Q000737:chemistry*; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: C539775:6-deoxy-6-((S-cysteamidopropyl(1,2-diamino)N,N'-bis(3-methoxysalicylidene)))-beta-cyclodextrin; C539774:6-deoxy-6-((S-cysteamidopropyl(1,2-diamino)N,N'-bis(salicylidene)))-beta-cyclodextrin; D047392:beta-Cyclodextrins; D008345:Manganese; D003300:Copper; D002374:Catalase; D009195:Peroxidase; D013482:Superoxide Dismutase