[Study on inclusion complexes of beta-cyclodextrin with zopiclone].
The inclusion complex formation of zopiclone with beta-yclodextrin was studied by using phase solubility method, and the formation constant for zopiclone-beta-cyclodextrin was determined. The solubility of zopiclone and the formation constant were enhanced with the increase in beta-cyclodextrin concentration and pH. The effect of temperature on the reaction was studied through thermodynamics, and the changes in entropy deltaS, enthalpy deltaH and free energy deltaG of the reaction were all negative, suggesting that the inclusion complexation is exothermic and can spontaneously occur by the balance of enthalpy driving and entropy opposing. The inclusion complex of zopiclone and beta-cyclodextrin was prepared by a method of solidgrinding, Stable inclusion complex in solid state was characterized by IR spectra and DTA. Results showed that zopiclone-delta-cyclodextrin conclusion complex could be formed, and beta-cyclodextrin is a desirable solubilizer for zopiclone.
Chen
Yuan-yuan
YY
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China. cyy622811@126.com
Liu
Jia-jia
JJ
Tang
Ke-wen
KW