Male circumcision and serologically determined human papillomavirus infection in a birth cohort.
Circumcision has been reported to protect against infection with human papillomavirus (HPV) in men, but results have been inconsistent. We followed males in a birth cohort born in Dunedin, New Zealand, in 1972 and 1973 from age 3 to 32 years. Seropositivity at age 32 years for the oncogenic types HPV-16 and 18, and the nononcogenic types 6 and 11, was studied in relation to maternal reports of circumcision status at age 3 for 450 men. Seropositivity to any of these types was associated with lifetime number of sexual partners (P = 0.03), and lower moral-religious emphasis of the family of origin (P < 0.001). Circumcision was not found to be protective, with the adjusted odds ratio (95% confidence interval) for HPV6/11/16/18 seropositivity among the circumcised compared with the uncircumcised being 1.4 (0.89-2.2).
Dickson
Nigel P
NP
Department of Preventive and Social Medicine, University of Otago Medical School, P.O. Box 913, Dunedin, New Zealand. nigel.dickson@otago.ac.nz
Ryding
Janka
J
van Roode
Thea
T
Paul
Charlotte
C
Herbison
Peter
P
Dillner
Joakim
J
Skegg
David C G
DC
D000293:Adolescent; D000328:Adult; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D002944:Circumcision, Male; D004797:Enzyme-Linked Immunosorbent Assay; D005837:Genitalia, Male / Q000821:virology; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D009520:New Zealand / Q000453:epidemiology; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D012307:Risk Factors; D011795:Surveys and Questionnaires