Advances in peptide pharmaceuticals.
Drug delivery strategies for peptide pharmaceuticals have incorporated a wide range of structure activity relationships, analog generation to impart protease resistance and increased bioavailability, novel formulations, and delivery systems to target optimal therapeutic dosing requirements. Advances in peptide pharmaceuticals have provided products for the treatment of diabetes, obesity, Crohn's disease, osteoporosis, cancer, cardiovascular disease, immunotherapy, acromegaly, enuresis, pain, and antimicrobials. Here we review these marketed peptides and new peptidomimetic therapies currently in clinical trials.
Stevenson
Cynthia L
CL
Independent Pharmaceuticals Consultant, 100 W. El Camino Real, Mountain View, CA 94040, USA. cynthialstevenson@gmail.com
D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D018716:Molecular Mimicry / Q000502:physiology; D010455:Peptides / Q000138:chemical synthesis / Q000502:physiology / Q000627:therapeutic use*; D013678:Technology, Pharmaceutical / Q000379:methods / Q000639:trends*
D001688:Biological Products; D010455:Peptides