Protective effect of taurine on rats with experimental insulin-dependent diabetes mellitus.
Taurine had the hypoglycemic effect during experimental insulin-dependent diabetes mellitus and decreased the concentrations of glucose and fructosamine, and increased the contents of insulin, C-peptide, and glycogen in the liver. Studying the dynamics of structural changes in pancreatic tissue confirmed a positive effect of taurine on beta-cell function. The protective effect of taurine manifested in the absence of morphological signs for alloxan-induced diabetes: decrease in the number and size of pancreatic islets, change in their distribution, reduction of beta-cell count, and accumulation of homogeneous deposits in islets.
Gavrovskaya
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LK
S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia. iem_gavr@mail.ru
Ryzhova
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OV
Safonova
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Matveev
A K
AK
Sapronov
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D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002096:C-Peptide / Q000378:metabolism; D002452:Cell Count; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004231:Diuresis / Q000187:drug effects; D004326:Drinking / Q000187:drug effects; D019270:Fructosamine / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000187:drug effects; D008099:Liver / Q000378:metabolism; D008297:Male; D010179:Pancreas / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D013654:Taurine / Q000627:therapeutic use*
D002096:C-Peptide; D007004:Hypoglycemic Agents; D007328:Insulin; D013654:Taurine; D019270:Fructosamine; D006003:Glycogen; D005947:Glucose