title: Regioselective Copper-catalyzed C-N and C-S Bond Formation using Amines, Thiols and Halobenzoic Acids.
abstract: A regioselective method for highly efficient C-N and C-S bond formation with 2-halobenzoic acids is described. The Cu/Cu(2)O-catalyzed reaction is carried out in 2-ethoxyethanol or ethylene glycol diethyl ether and does not require the use of strong base or other additives. This procedure eliminates the need for acid protection, tolerates a wide range of functional groups and provides aromatic and aliphatic amines and sulfides in 81 to 99% yield.
authors.affiliation: Department of Chemistry, Georgetown University, Washington, DC 20057.
authors.forename: Shuanglong
authors.initials: S
authors.lastname: Liu
authors.forename: John Paul C
authors.initials: JP
authors.lastname: Pestano
authors.forename: Christian
authors.initials: C
authors.lastname: Wolf