title: Subacute onset of deafness and vertigo in a patient with leptomeningeal metastasis from ovarian cancer.
abstract: Ovarian carcinoma is a common gynecological malignancy. Distant metastases usually involve the liver and lung while neurological complications are rare. We describe the case of a 63-year-old woman diagnosed from an ovarian carcinoma with peritoneal seed, which was treated surgically and with chemotherapy. After 4 years she was admitted to our Department for the development of subacute right deafness, vertigo and imbalance. MRI revealed the presence of leptomeningeal carcinomatosis and an expansive formation in the right pontocerebellar angle, suggesting involvement of the right VIII cranial nerve. Examination of the cerebrospinal fluid disclosed the presence of neoplastic cells. Subsequently the patient rapidly deteriorated and eventually died. Involvement of VIII cranial nerve as the presentation of leptomeningeal carcinomatosis in ovarian carcinoma is rare. In the literature at least two other cases presented with deafness, suggesting that leptomeningeal carcinomatosis should be considered in the differential diagnosis when deafness appears in a cancer patient.
authors.affiliation: Department of Neurosciences, University of Padova, Via Giustiniani, 5, 35100 Padova, Italy.
authors.forename: Roberta
authors.initials: R
authors.lastname: Vitaliani
authors.forename: Marco
authors.initials: M
authors.lastname: Spinazzi
authors.forename: Anna Rosa
authors.initials: AR
authors.lastname: Del Mistro
authors.forename: Renzo
authors.initials: R
authors.lastname: Manara
authors.forename: Bruno
authors.initials: B
authors.lastname: Tavolato
authors.forename: Domenico Marco
authors.initials: DM
authors.lastname: Bonifati
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000556:secondary*; D002530:Cerebellopontine Angle / Q000473:pathology / Q000503:physiopathology; D002555:Cerebrospinal Fluid / Q000166:cytology; D003638:Deafness / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D055756:Meningeal Carcinomatosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008577:Meningeal Neoplasms / Q000556:secondary*; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D013129:Spinal Puncture; D014057:Tomography, X-Ray Computed; D014717:Vertigo / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D000159:Vestibulocochlear Nerve / Q000473:pathology / Q000503:physiopathology