title: Alcohol use and cardiovascular health outcomes: a comparison across age and gender in the Winnipeg Health and Drinking Survey Cohort.
abstract: BACKGROUND
  research has reliably demonstrated cardioprotection from regular alcohol use. Heavy episodic drinking (HED), however, negates these beneficial effects and increases the risk of cardiovascular disease (CVD). The impact of age on the health effects of episodic drinking has not been evaluated.
  
  
  OBJECTIVE
  to examine the association between alcohol volume and pattern of consumption on the risk of cardiovascular morbidity and mortality across the lifespan.
  
  
  METHODS
  prospective, community-based cohort study of adults in Winnipeg, Manitoba, Canada.
  
  
  METHODS
  a total of 1,154 participants (580 men and 574 women) aged 18-64 surveyed at baseline (1990-91) on alcohol consumption levels and pattern of use.
  
  
  METHODS
  usual alcohol consumption was measured using a quantity-frequency approach. HED was estimated by asking participants how often they consumed eight or more drinks in one sitting in the past year. Questions were asked separately for wine, beer and spirits. Surveillance for cardiovascular events was conducted for 10 years (i.e. up to age 74 years). Diagnoses of CVD were obtained via health utilization records. Cox proportional hazard models were derived for both genders and for 'young adults' (baseline age 18-34), 'middle-aged adults' (baseline age 35-49) and 'older adults' (baseline 50-64). Models were adjusted for marital status, cigarette smoking status and educational level.
  
  
  RESULTS
  Reduced risk of CVD was associated with usual consumption, whereas an increased risk was associated with HED. Among male usual drinkers, cardioprotection was afforded only to middle and older age groups. The benefits of regular consumption were seen only in the youngest age group among women. The heaviest usual consumption category was associated with a decreased risk of CVD in men. Heavy episodic drinking increased the risk of coronary heart disease in middle-aged men and was marginally significant in middle-aged women. Risk of hypertension was elevated in older men with heavy episodic drinking.
  
  
  CONCLUSIONS
  The well-established relationship between regular alcohol consumption and decreased risk of CVD may not become evident until middle age or older in men. Women may benefit from usual consumption at a much younger age. In both sexes, however, these beneficial effects of alcohol use are negated when alcohol is consumed in a heavy episodic drinking pattern, particularly for middle-aged and older men.
authors.affiliation: Research Associate, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, R3A 1R9, Canada. wssnow@mts.net
authors.forename: Wanda M
authors.initials: WM
authors.lastname: Snow
authors.forename: Robert
authors.initials: R
authors.lastname: Murray
authors.forename: Okechukwa
authors.initials: O
authors.lastname: Ekuma
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Tyas
authors.forename: Gordon E
authors.initials: GE
authors.lastname: Barnes
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000375:Aging; D000428:Alcohol Drinking / Q000401:mortality*; D015331:Cohort Studies; D003327:Coronary Disease / Q000401:mortality* / Q000517:prevention & control; D003625:Data Collection; D005260:Female; D006801:Humans; D006973:Hypertension / Q000401:mortality* / Q000517:prevention & control; D008297:Male; D008350:Manitoba / Q000453:epidemiology; D008875:Middle Aged; D009017:Morbidity; D012307:Risk Factors; D017678:Sex Distribution; D055815:Young Adult