title: Effects of omeprazole on plasma levels of raltegravir.
abstract: Raltegravir, a human immunodeficiency virus type 1 (HIV-1) integrase inhibitor, has pH-dependent solubility. Raltegravir plasma concentration increases with omeprazole coadministration in healthy subjects; this is likely secondary to an increase in bioavailability attributable to increased gastric pH. Increased gastric pH has been reported in HIV-1-infected individuals, and the effects of omeprazole in this intended population may be diminished. Further investigation is necessary.
authors.affiliation: Merck & Co., Whitehouse Station, Rahway, NJ 07065-0900, USA. marian_iwamoto@merck.com
authors.forename: Marian
authors.initials: M
authors.lastname: Iwamoto
authors.forename: Larissa A
authors.initials: LA
authors.lastname: Wenning
authors.forename: Bach-Yen
authors.initials: BY
authors.lastname: Nguyen
authors.forename: Hedy
authors.initials: H
authors.lastname: Teppler
authors.forename: Allison R
authors.initials: AR
authors.lastname: Moreau
authors.forename: Rand R
authors.initials: RR
authors.lastname: Rhodes
authors.forename: William D
authors.initials: WD
authors.lastname: Hanley
authors.forename: Bo
authors.initials: B
authors.lastname: Jin
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Harvey
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Breidinger
authors.forename: Neal
authors.initials: N
authors.lastname: Azrolan
authors.forename: H Frank
authors.initials: HF
authors.lastname: Farmer
authors.forename: Robin D
authors.initials: RD
authors.lastname: Isaacs
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: Chodakewitz
authors.forename: Julie A
authors.initials: JA
authors.lastname: Stone
authors.forename: John A
authors.initials: JA
authors.lastname: Wagner
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010949:Plasma / Q000737:chemistry*; D011760:Pyrrolidinones / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000068898:Raltegravir Potassium; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium; D009853:Omeprazole