Use of whole cell culture of Aeromonas sp. as enantioselective scavenger: a facile preparation of l-amino acid derivatives in high enantiomeric excess.
The bacterium Aeromonas sp. (CGMCC 2226) can enantioselectively scavenge D-isomer, making L-amino acid derivatives (AADs) in high ee. The enantioselective scavenger (ES) has shown a broad substrate scope. Eleven L-AADs, Phe derivatives substituted with methyl-, mono- and dichloro-, bromo-, and nitro-group, were produced in high ee from corresponding racemates.
Zhang
Zizhang
Z
Department of Chemistry, Zhejiang University, 38 Zheda Road, Hangzhou 310027, PR China. zhangzz@zju.edu.cn
D000333:Aeromonas / Q000254:growth & development / Q000378:metabolism*; D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D012248:Rhodotorula / Q000187:drug effects; D013237:Stereoisomerism
D000596:Amino Acids