NF-kappaB: the inducible factors of HIV-1 transcription and their inhibitors.
NF-kappaB (NF-kappaB), the transcription factors of HIV-1, play an important role in triggering HIV transcription. The inhibition of NF-kappaB activation and their signaling pathway offers a potential anti-HIV therapy strategy. This review reports the mode of action of NF-kappaB in triggering HIV-1 transcription and the status of the inhibitors.
Mingyan
Yu
Y
Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012 P.R. China.
Xinyong
Liu
L
De Clercq
Erik
E
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D020672:I-kappa B Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D014158:Transcription, Genetic
D019380:Anti-HIV Agents; D020672:I-kappa B Proteins; D016328:NF-kappa B; D014157:Transcription Factors