Mechanism of eosinophilic esophagitis.
Eosinophilic esophagitis (EoE) is a newly recognized disease and is an emerging entity throughout developing and developed countries, including the United States. Therefore, understanding the causes, natural history, diagnosis, and management is important for future therapeutic interventions. The pathogenesis of EoE is still not clear, but a growing body of evidence has established that this condition represents a T-cell-mediated immune response involving several proinflammatory mediators and chemoattractants known to regulate eosinophilic accumulation in the esophagus, such as IL-4, IL-5, IL-3 and eotaxin-1, -2, and -3. Determining the mechanism or mechanisms through which human esophageal-derived factors ultimately induce the functional abnormalities observed, and to which antigens patients who have EoE are sensitized that lead to the manifestation of symptoms, is of significant interest.
Mishra
Anil
A
Department of Pediatrics, Division of Allergy and Immunology, 3333 Burnnet Avenue, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH 45229, USA. anil.mishra@cchmc.org
D000485:Allergens / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D002631:Chemotactic Factors, Eosinophil / Q000276:immunology*; D004035:Diet Therapy; D004802:Eosinophilia / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004941:Esophagitis / Q000175:diagnosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D005512:Food Hypersensitivity / Q000150:complications / Q000276:immunology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular; D015848:Interleukin-5 / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000150:complications / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D000485:Allergens; D000911:Antibodies, Monoclonal; D002631:Chemotactic Factors, Eosinophil; D005938:Glucocorticoids; D015848:Interleukin-5