Postural instability in cerebellar ataxia: correlations of knee, arm and trunk movements to center of mass velocity.
The aim of this study was to investigate the correlations between body segment movements and center of mass (COM) velocity during pathological balance corrections of spinocerebellar ataxia (SCA) patients compared with controls, and to relate correlations indicating instability to EMG activity differences. Eighteen SCA patients and 21 age-matched controls were tested. Upright standing was perturbed using rotations of the support surface. We recorded body motion and surface EMG. For lateral perturbations peaks in COM lateral velocity were larger in SCA patients than controls. These peaks were correlated with increased ("hypermetric") trunk roll downhill and reduced uphill knee flexion velocity. Subsequent arm abduction partially corrected the lateral instability. Early balance correcting responses in knee and paraspinal muscles showed reduced amplitudes compared with normal responses. Later responses were consistent with compensation mechanisms for the lateral instability created by the stiffened knee and pelvis. We conclude that truncal hypermetria coupled with insufficient uphill knee flexion is the primary cause of lateral instability in SCA patients. Holding the knees and pelvis more rigid possibly permits a reduction in the controlled degrees of freedom and concentration on arm abduction to improve lateral instability. For backwards perturbations excessive posterior COM velocity coincided with marked trunk hypermetric flexion forwards. We concluded that this flexion and the ensuing backwards shift of the pelvis result from rigidity which jeopardizes posterior stability. Timing considerations and the lack of confirmatory changes in amplitudes of EMG activity suggest that lateral and posterior instability in SCA is primarily a biomechanical response to pelvis and knee rigidity resulting from increased muscle background activity rather than changed evoked responses.
Küng
U M
UM
Department of Otorhinolaryngology, University Hospital, Petersgraben 4, CH-4031 Basel, Switzerland.
Horlings
C G C
CG
Honegger
F
F
Kremer
H P H
HP
Bloem
B R
BR
van De Warrenburg
B P C
BP
Allum
J H J
JH
D000328:Adult; D000704:Analysis of Variance; D001132:Arm / Q000294:innervation / Q000503:physiopathology*; D001696:Biomechanical Phenomena; D002524:Cerebellar Ataxia / Q000150:complications / Q000473:pathology*; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D007717:Knee / Q000294:innervation / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology*; D018482:Muscle, Skeletal / Q000503:physiopathology; D004856:Postural Balance / Q000502:physiology*; D011187:Posture; D011434:Proprioception; D012678:Sensation Disorders / Q000209:etiology / Q000473:pathology*; D013223:Statistics as Topic; D034941:Upper Extremity