title: A case of fatal strongyloidiasis in a patient with chronic lymphocytic leukemia and molecular characterization of the isolate.
abstract: Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.
authors.affiliation: School of Public Health, Medical Sciences/ University of Tehran, Tehran, Iran. keiaeshr@sina.tums.ac.ir
authors.forename: Eshrat Beigom
authors.initials: EB
authors.lastname: Kia
authors.forename: Hamid Reza
authors.initials: HR
authors.lastname: Rahimi
authors.forename: Hossein
authors.initials: H
authors.lastname: Mirhendi
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Nilforoushan
authors.forename: Ardeshir
authors.initials: A
authors.lastname: Talebi
authors.forename: Farzaneh
authors.initials: F
authors.lastname: Zahabiun
authors.forename: Hamid
authors.initials: H
authors.lastname: Kazemzadeh
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Meamar
mesh_terms: D000368:Aged; D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use; D007814:Larva; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000469:parasitology; D008297:Male; D017171:Strongyloides stercoralis / Q000145:classification*; D013322:Strongyloidiasis / Q000150:complications* / Q000188:drug therapy
chemical_list: D000871:Anthelmintics; D007559:Ivermectin; D015766:Albendazole