title: Therapy for the altered mineral metabolism of chronic kidney disease: implications for vascular calcification.
abstract: The development of chronic kidney disease (CKD) is associated with poor outcomes largely due an increased likelihood of adverse cardiovascular events. Many factors are playing a role in cardiovascular disease in CKD including the development of vascular calcification (VC). Studies have indeed shown that the presence of VC is associated with decreased survival among patients with CKD. The pathogenesis of VC is itself multi-factorial. LikeLy playing a significant role is the altered mineral metabolism of CKD. Management of the altered mineral metabolism in CKD is quite difficult and may also play a role in the pathogenesis of VC. In this manuscript, we will review the pathogenesis of the altered mineral metabolism of CKD, its management, and how both may play a role in the development of VC.
authors.affiliation: University of Missouri-Columbia School of Medicine, Department on Internal Medicine, Columbia, MO 65212, USA. saabg@health.missouri.edu
authors.forename: Georges
authors.initials: G
authors.lastname: Saab
authors.forename: Adam T
authors.initials: AT
authors.lastname: Whaley-Connell
authors.forename: Ramesh
authors.initials: R
authors.lastname: Khanna
authors.forename: James R
authors.initials: JR
authors.lastname: Sowers
mesh_terms: D002114:Calcinosis / Q000209:etiology / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D054559:Hyperphosphatemia / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D008903:Minerals / Q000378:metabolism*; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy*
chemical_list: D008903:Minerals