Cerebral monoamine oxidase A inhibition in tobacco smokers confirmed with PET and [11C]befloxatone.
The inhibition of cerebral monoamine oxidases (MAOs) by cigarette smoke components could participate to the tobacco addiction. However, the actual extent of this inhibition in vivo in smokers is still poorly known. We investigated cerebral MAO-A availability in 7 tobacco-dependent subjects and 6 healthy nonsmokers, using positron emission tomography (PET) and the MAO-A selective radioligand [C]befloxatone. In comparison to nonsmokers, smokers showed a significant overall reduction of [C]befloxatone binding potential (BP) in cortical areas (average reduction, -60%) and a similar trend in caudate and thalamus (-40%). Our findings confirm a widespread inhibition of cerebral MAO-A in smokers. This mechanism may contribute to tobacco addiction and for a possible mood-modulating effect of tobacco.
Leroy
Claire
C
INSERM U797, Research Unit Neuroimaging and Psychiatry, Orsay, France. claire.leroy@cea.fr
Bragulat
Véronique
V
Berlin
Ivan
I
Grégoire
Marie-Claude
MC
Bottlaender
Michel
M
Roumenov
Dimitri
D
Dollé
Frédéric
F
Bourgeois
Sandrine
S
Penttilä
Jani
J
Artiges
Eric
E
Martinot
Jean-Luc
JL
Trichard
Christian
C
D000328:Adult; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000201:enzymology*; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism / Q000494:pharmacology*; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology; D018722:Nicotinic Agonists / Q000008:administration & dosage / Q000494:pharmacology; D010080:Oxazoles / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012907:Smoking / Q000503:physiopathology; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D008996:Monoamine Oxidase Inhibitors; D018722:Nicotinic Agonists; D010080:Oxazoles; D019275:Radiopharmaceuticals; C090014:befloxatone; D009538:Nicotine; D008995:Monoamine Oxidase