In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.
The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.
Bourreau
Eliane
E
Immunologie des Leishmanioses, Institut Pasteur de la Guyane, EA 2188, Centre Hospitalier Andrée Rosemon, Cayenne, French Guyana.
Ronet
Catherine
C
Darsissac
Edith
E
Lise
Marie-Claire
MC
Marie
Dominique Sainte
DS
Clity
Emmanuel
E
Tacchini-Cottier
Fabienne
F
Couppie
Pierre
P
Launois
Pascal
P
D000293:Adolescent; D000328:Adult; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D018334:Leishmania guyanensis / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010419:Pentamidine / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D017211:Treatment Failure
D000981:Antiprotozoal Agents; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D012333:RNA, Messenger; D016753:Interleukin-10; D010419:Pentamidine