title: Photopolymerization of methacrylated chitosan/PNIPAAm hybrid dual-sensitive hydrogels as carrier for drug delivery.
abstract: A series of hybrid hydrogels based on glycidyl methacrylated chitosan (CS-GMA) and N-isopropylacrylamide (NIPAAm) were designed and prepared via photopolymerization technology. The hydrogels were characterized by Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC) and optical transmittance. The interior morphology of hydrogels was investigated by scanning electron microscopy (SEM). The swelling experiment results revealed that hybrid hydrogel exhibited combined pH and temperature sensitivities. Acid orange 8 (AO8) and 5-flurouracil (5-Fu) were selected as model drugs for examining their release from hydrogels. The results suggested that hydrogel composition and pH value of buffer solution had great influences on release profiles.
authors.affiliation: Beijing University of Chemical Technology, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Kemin
authors.initials: K
authors.lastname: Wang
authors.forename: Dongzhi
authors.initials: D
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Nie
mesh_terms: D000165:Acridine Orange / Q000737:chemistry; D000178:Acrylamides / Q000737:chemistry / Q000528:radiation effects*; D000180:Acrylic Resins; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008027:Light; D008855:Microscopy, Electron, Scanning; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry / Q000528:radiation effects*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D048271:Chitosan; D000165:Acridine Orange; D005472:Fluorouracil