[NF-kappa B activation in peripheral blood mononuclear cells of children with epilepsy].
OBJECTIVE
To study the changes and significance of NF-kappa B activation in peripheral blood mononuclear cells (PBMC) of children with epilepsy.


METHODS
NF-kappa B activation in PBMC was assayed by the flow cytometry in 32 healthy children and 64 children with epilepsy before and after treatment. The 64 epileptic children were subdivided into three groups: systemic seizure, partial seizure and unknown classification.


RESULTS
NF-kappa B activation in PBMC in three epilepsy subgroups were significantly higher than that in healthy controls. The systemic seizure group showed significantly increased NF-kappa B activation in PBMC compared with the partial seizure group (p<0.01) and the unknown classification group (p<0.05). After treatment NF-kappa B activation in PBMC in three epilepsy subgroups was significantly reduced (p<0.01).


CONCLUSIONS
NF-kappa B activation in PBMC increased in children with epilepsy, and it was positively correlated with the severity of seizures.
Wang
Jian-Ping
JP
Department of Pediatrics, People's Hospital of Gansu Province, Lanzhou 730000, China. wjpshengyiok@126.com
Cao
Ya-Qin
YQ
Su
Yi-Fan
YF
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007223:Infant; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D016328:NF-kappa B / Q000378:metabolism*
D016328:NF-kappa B