Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).
Meyre
David
D
CNRS 8090-Institute of Biology, Pasteur Institute, 59000 Lille, France.
Delplanque
Jérôme
J
Chèvre
Jean-Claude
JC
Lecoeur
Cécile
C
Lobbens
Stéphane
S
Gallina
Sophie
S
Durand
Emmanuelle
E
Vatin
Vincent
V
Degraeve
Franck
F
Proença
Christine
C
Gaget
Stefan
S
Körner
Antje
A
Kovacs
Peter
P
Kiess
Wieland
W
Tichet
Jean
J
Marre
Michel
M
Hartikainen
Anna-Liisa
AL
Horber
Fritz
F
Potoczna
Natascha
N
Hercberg
Serge
S
Levy-Marchal
Claire
C
Pattou
François
F
Heude
Barbara
B
Tauber
Maithé
M
McCarthy
Mark I
MI
Blakemore
Alexandra I F
AI
Montpetit
Alexandre
A
Polychronakos
Constantin
C
Weill
Jacques
J
Coin
Lachlan J M
LJ
Asher
Julian
J
Elliott
Paul
P
Järvelin
Marjo-Riitta
MR
Visvikis-Siest
Sophie
S
Balkau
Beverley
B
Sladek
Rob
R
Balding
David
D
Walley
Andrew
A
Dina
Christian
C
Froguel
Philippe
P
D000328:Adult; D017668:Age of Onset; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D002352:Carrier Proteins / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D005060:Europe / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000235:genetics; D000077296:Niemann-Pick C1 Protein; D009767:Obesity, Morbid / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011153:Population; D011506:Proteins / Q000235:genetics; D051257:Proto-Oncogene Proteins c-maf / Q000235:genetics; D040641:Quantitative Trait Loci; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D012307:Risk Factors
D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C495607:MAF protein, human; C470072:MC4R protein, human; D008562:Membrane Glycoproteins; C106881:NPC1 protein, human; D000077296:Niemann-Pick C1 Protein; C484578:PTER protein, human; D011506:Proteins; D051257:Proto-Oncogene Proteins c-maf; D044105:Receptor, Melanocortin, Type 4; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human