[Resistance to platelet antiaggregants: the cardiologist's point of view].
The concept of resistance to aspirin and clopidogrel, initially described in the laboratory, has currently been reinforced with recent epidemiological clinical data. One of the elements of particular importance for the cardiologist is the possible participation of this resistance in the process of coronary stent thrombosis, a problem which appeared to be solved early in the 1990s with the introduction of thienopyridines. This complication has however become preoccupying again, particularly when occurring late, notably since the widespread use of biologically active coronary endoprostheses. Nevertheless, the debate continues concerning the usefulness of the biological definition of this concept since we still do not have correctly standardized coherent biological tools that can be used in the clinical setting to detect "resistant" patients. Since there is no real therapeutic strategy which should be applied in the event of resistance, there still is little interest in developing screening methods. But the cardiology community can learn from this concept. We should revisit the principles of revascularization within the framework of the rules of good clinical practice, without speculating about the possible therapeutic finality which might develop should such and such a phenomenon occur.
Metz
D
D
EA 3801, laboratoire d'hématologie biologique, service de cardiologie, centre hospitalier universitaire Robert-Debré, rue du Pr-Kochman, 51092 Reims, France. dmetz@chu-reims.fr
Hézard
N
N
Duval
S
S
Tassan-Mangina
S
S
Deschildre
A
A
Brasselet
C
C
Nguyen
P
P
D001241:Aspirin / Q000494:pharmacology* / Q000627:therapeutic use; D002309:Cardiology / Q000379:methods; D000077144:Clopidogrel; D004351:Drug Resistance; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D015607:Stents; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000494:pharmacology
D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin