A case of fatal strongyloidiasis in a patient with chronic lymphocytic leukemia and molecular characterization of the isolate.
Strongyloides stercoralis is a human intestinal parasite which may lead to complicated strongyloidiasis in immunocompromised. Here, a case of complicated strongyloidiasis in a patient with chronic lymphocytic leukemia is reported. Presence of numerous S. stercoralis larvae in feces and sputum confirmed the diagnosis of hyperinfection syndrome in this patient. Following recovery of filariform larvae from agar plate culture of the stool, the isolate was characterized for the ITS1 region of ribosomal DNA gene by nested-PCR and sequencing. Albendazole therapy did not have cure effects; and just at the beginning of taking ivermectin, the patient died. The most important clue to prevent such fatal consequences is early diagnosis and proper treatment.
Kia
Eshrat Beigom
EB
School of Public Health, Medical Sciences/ University of Tehran, Tehran, Iran. keiaeshr@sina.tums.ac.ir
Rahimi
Hamid Reza
HR
Mirhendi
Hossein
H
Nilforoushan
Mohammad Reza
MR
Talebi
Ardeshir
A
Zahabiun
Farzaneh
F
Kazemzadeh
Hamid
H
Meamar
Ahmad Reza
AR
D000368:Aged; D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use; D007814:Larva; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000469:parasitology; D008297:Male; D017171:Strongyloides stercoralis / Q000145:classification*; D013322:Strongyloidiasis / Q000150:complications* / Q000188:drug therapy
D000871:Anthelmintics; D007559:Ivermectin; D015766:Albendazole