PDGF-D signaling: a novel target in cancer therapy.
Platelet-derived growth factor-D (PDGF-D) is a newly recognized growth factor that can regulate many cellular processes, including cell proliferation, transformation, invasion, and angiogenesis by specifically binding to and activating its cognate receptor PDGFR-beta. The functions of PDGF-D in human cancer progression are largely unknown. We discuss here the role of PDGF-D signaling pathway in cancer and how its deregulation is involved in tumor development and progression to metastatic disease.
Wang
Zhiwei
Z
Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA.
Kong
Dejuan
D
Li
Yiwei
Y
Sarkar
Fazlul H
FH
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006801:Humans; D008222:Lymphokines / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000502:physiology; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects*
D000970:Antineoplastic Agents; D008222:Lymphokines; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor; D017479:Receptors, Platelet-Derived Growth Factor