Effects of dietary supplementation with medicinal fungus in fasting glycemia levels of patients with colorectal cancer: a randomized, double-blind, placebo-controlled clinical study.
OBJECTIVE
The objective of this study was to evaluate the effects of dietary supplementation with Agaricus sylvaticus medicinal fungus in fasting glycemia of post-surgery patients with colorectal cancer.


METHODS
Proctology Ambulatory of Federal District Base Hospital-Brazil.


METHODS
Fifty-six colorectal cancer patients in postsurgery phase, stadiums phase I, II and II, which followed specific criteria of inclusion and exclusion.


METHODS
All patients were randomized in two groups: supplemented with Agaricus sylvaticus fungus (30 mg/kg/day) and placebo, and were followed up for six months. Subjects were divided later on according to BMI--Body Mass Index, sex and stage. Three fasting glycemia evaluations were carried out throughout the treatment.


RESULTS
Subjects presented BMI medium = 24.65 kg/m2 (57.1% women and 42.9% men). The placebo group (average age 59.14 +/- 12.95 years) had initial glycemia levels of 94.36 +/- 15.34 mg/dL, after three months 98.12 +/- 15.54 mg/dL (p = 0.03) and in the sixth month 98.52 +/- 9.03 mg/dL (p = 0.01). The supplemented group (average age of 56.34 +/- 15.53 years) had initial glycemia levels of 95.92 +/- 11.64 mg/dL, after three months 94.88 +/- 12.24 mg/dL (p = 0.65) and, in the sixth month, a significant reduction to 92.86 +/- 6.82 mg/dL (p = 0.01).


CONCLUSIONS
The results suggest that the dietary supplementation with Agaricus sylvaticus medicinal fungus can significantly reduce fasting glycemia levels of colorectal cancer patients in post-surgery phase.
Fortes
R C
RC
Science and Education School Sena Aires-GO, University of Brasilia-DF, Brazil. renatacfortes@yahoo.com.br
Recôva
V L
VL
Melo
A L
AL
Novaes
M R C G
MR
D000364:Agaricus; D001786:Blood Glucose / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000097:blood*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005215:Fasting; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose