Alkaloids from the South China Sea Black Coral Antipathes dichotoma.
A new carbazole alkaloid, antipathine A (1), together with three known zoanthoxanthin alkaloids (2--4) was isolated from the EtOH/CH2Cl2 extracts of the South China Sea black coral Antipathes dichotoma. The structure of 1 was determined on the bases of extensive spectroscopic analysis, including 1D and 2D NMR data. Compounds 1 and 2 showed moderate cytotoxicity against human stomach carcinoma SGC-7901 cell line with IC50 of 67.38 and 86.40 microg/ml, respectively, and 1 and 2 also showed weak cytotoxicity toward human liver carcinoma Hep_G2 cell line.
Qi
Shu-Hua
SH
Key Laboratory of Marine Bio-resourses Sustainable Utilization/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, The Chinese Academy of Sciences, Guangdong, PR China. shuhuaqi2001@yahoo.com
Su
Guo-Chen
GC
Wang
Yi-Fei
YF
Liu
Qiu-Ying
QY
Gao
Cheng-Hai
CH
D000470:Alkaloids / Q000737:chemistry* / Q000627:therapeutic use; D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D045744:Cell Line, Tumor; D002681:China; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D008113:Liver Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D013274:Stomach Neoplasms / Q000188:drug therapy
D000470:Alkaloids; D000970:Antineoplastic Agents