title: Normal tissue reactions to radiotherapy: towards tailoring treatment dose by genotype.
abstract: A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy.
authors.affiliation: Department of Oncology, University of Cambridge, Oncology Centre, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK. gillbarnett@doctors.org.uk
authors.forename: Gillian C
authors.initials: GC
authors.lastname: Barnett
authors.forename: Catherine M L
authors.initials: CM
authors.lastname: West
authors.forename: Alison M
authors.initials: AM
authors.lastname: Dunning
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Elliott
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Coles
authors.forename: Paul D P
authors.initials: PD
authors.lastname: Pharoah
authors.forename: Neil G
authors.initials: NG
authors.lastname: Burnet
mesh_terms: D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000532:radiotherapy*; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects*