title: Oxidant stress in healthy normal-weight, overweight, and obese individuals.
abstract: This study was undertaken to investigate the association among BMI and lipid hydroperoxide (LH), total antioxidant status (TAS), superoxide dismutase (SOD), and reduced glutathione (GSH). Ninety (n = 90) healthy males and females (n = 23/67) (29 normal weight (BMI: 22.74 +/- 0.25 kg/m(2)), 36 overweight (BMI: 27.18 +/- 0.23 kg/m(2)), and 25 obese (33.78 +/- 0.48 kg/m(2))) participated in the study. Data collected included anthropometric measures, fasting blood glucose, lipid profile, LH, TAS, and enzymatic antioxidants (SOD, and reduced GSH). The results of the study showed that obese individuals had significantly increased LH levels compared to normal-weight individuals (obese vs. normal weight (0.88 +/- 0.05 vs. 0.67 +/- 0.03 micromol/l, P < 0.01)) but the increased levels were not significantly different when compared to the overweight group (obese vs. overweight (0.88 +/- 0.05 vs. 0.79 +/- 0.05 micromol/l)). No other consistent significant differences in TAS, SOD, and GSH were identified between groups. This study concluded that only obesity and not moderate overweight elevates LH levels. Furthermore, the levels of TAS, SOD, and GSH in obesity do not explain the increased LH levels observed in obesity.
authors.affiliation: School of Physical Education and Sport Sciences, University of Bedfordshire, Bedford, UK. louise.brown@beds.ac.uk
authors.forename: Louise A
authors.initials: LA
authors.lastname: Brown
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Kerr
authors.forename: Paul
authors.initials: P
authors.lastname: Whiting
authors.forename: Nicholas
authors.initials: N
authors.lastname: Finer
authors.forename: Jane
authors.initials: J
authors.lastname: McEneny
authors.forename: Tony
authors.initials: T
authors.lastname: Ashton
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D005260:Female; D005978:Glutathione / Q000097:blood; D006262:Health; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D050177:Overweight / Q000097:blood / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D008054:Lipid Peroxides; D008055:Lipids; D013482:Superoxide Dismutase; D005978:Glutathione