Iotrochotamides I and II: new ceramides from the Indonesian sponge Iotrochota purpurea.
Our search for biologically active marine natural products led to the isolation of two new ceramides, iotrochotamide I and iotrochotamide II, together with three known 6-bromoindole alkaloids (6-bromo-1H-indole-3-carbaldehyde, 6-bromo-1H-indole-3-carboxylic acid methyl ester, and 6-bromo-1H-indole-3-carboxylic acid ethyl ester) from the sponge Iotrochota purpurea collected in Indonesia. The structure elucidation of these compounds was secured by spectroscopic methods (1H, 13C, DEPT, COSY, HMQC and HMBC), accurate mass measurements (ESI, EI and GS-MS) as well as comparison with known compounds.
Ibrahim
Sabrin R M
SR
Faculty of Pharmacy, Pharmacognosy Department, Assiut University, Assiut, Egypt. sabrins2002@yahoo.com
Mohamed
Gamal A
GA
Fouad
Mostafa A
MA
El-Khayat
Ehab S
ES
Proksch
Peter
P
D000818:Animals; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification*; D008401:Gas Chromatography-Mass Spectrometry; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D007214:Indonesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
D002518:Ceramides; D026121:Indole Alkaloids; C534669:iotrochotamide I; C534670:iotrochotamide II