[Radiation-induced maxillary malignancies: complications of radiotherapy treatment for head-neck malignant tumors].
OBJECTIVE
To investigate the incidence of radiation-induced maxillary malignancy after radiotherapy for head and neck cancer.


METHODS
A total of 273 patients who suffered from osteoradionecrosis after radiotherapy for head and neck cancer were evaluated. Among them, 6 patients were presented with carcinoma and sarcoma arising from maxillary area after radiotherapy.


RESULTS
Radiation-induced maxillary cancers happened at a rate of 2.2% in the patients with osteoradionecrosis. There were no statistically significant differences in age, sex and the time interval between the radiotherapy and the cancer occurrence.


CONCLUSIONS
Radiation-induced malignancy after radiotherapy for head and neck cancer is mainly located in maxilla, presenting as squamous cell carcinoma or sarcoma of the maxillary sinus.
Wang
Jian-Ning
JN
Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, China. arhning@sina.com
Li
Ru-Yao
RY
Cui
Min-Yi
MY
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D007573:Jaw Neoplasms / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000000981:diagnostic imaging; D009381:Neoplasms, Radiation-Induced; D010025:Osteoradionecrosis / Q000209:etiology; D011859:Radiography; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D055815:Young Adult