title: Effects of inhibitory rTMS on bladder function in Parkinson's disease patients.
abstract: Patients affected by Parkinson's disease (PD) may present with lower urinary tract (LUT) dysfunction characterized by involuntary detrusor overactivity. We evaluated possible impact of a 2-week course of low frequency 1 Hz repetitive transcranial magnetic stimulation (rTMS) on LUT behavior in eight advanced PD patients complaining of urinary disturbances. We tested the effects of rTMS measuring urodynamic examination and the International Prostate Symptoms Score (IPSS) questionnaire, used for evaluation of subjective LUTS. rTMS was able to improve temporarily LUT behavior in PD patients, increasing bladder capacity and the first sensation of filling phase. Moreover, a reduction of IPSS score was noticed, due to an improvement on filling phase symptoms. The beneficial effects assessed with the IPSS lasted for up to 2 weeks after the end of the stimulation. rTMS seems to be an effective, noninvasive alternative treatment for PD patients with urinary disturbances.
authors.affiliation: UOC Neurologia, Ospedale S. Eugenio, Rome, Italy.
authors.forename: Livia
authors.initials: L
authors.lastname: Brusa
authors.forename: Enrico
authors.initials: E
authors.lastname: Finazzi Agrò
authors.forename: Filomena
authors.initials: F
authors.lastname: Petta
authors.forename: Francesco
authors.initials: F
authors.lastname: Sciobica
authors.forename: Sara
authors.initials: S
authors.lastname: Torriero
authors.forename: Emanuele
authors.initials: E
authors.lastname: Lo Gerfo
authors.forename: Cesare
authors.initials: C
authors.lastname: Iani
authors.forename: Paolo
authors.initials: P
authors.lastname: Stanzione
authors.forename: Giacomo
authors.initials: G
authors.lastname: Koch
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy / Q000453:epidemiology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D013997:Time Factors; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D053201:Urinary Bladder, Overactive / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy; D014563:Urodynamics
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa