title: Soluble fibers inhibit carotenoid micellization in vitro and uptake by Caco-2 cells.
abstract: We evaluated the effects of soluble fibers on beta-carotene and lutein micellization during simulated digestion in vitro, and on carotenoid uptake from mixed micelles by Caco-2 cells. Medium- and high-viscosity alginates and pectins inhibited carotenoid micellization and cellular uptake relative to the fiber-free control. Alginates, carboxy-methylcelluloses, and methylcelluloses inhibited beta-carotene uptake mainly by increasing medium viscosity, but pectins might inhibit carotenoid uptake by additional mechanisms.
authors.affiliation: National Food Research Institute, National Agriculture and Food Research Organization, Tsukuba, Ibaraki.
authors.forename: Lina
authors.initials: L
authors.lastname: Yonekura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nagao
mesh_terms: D000464:Alginates / Q000494:pharmacology; D018938:Caco-2 Cells; D002338:Carotenoids / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D014975:Lutein; D008747:Methylcellulose / Q000494:pharmacology; D008823:Micelles; D014783:Viscosity; D019207:beta Carotene / Q000378:metabolism
chemical_list: D000464:Alginates; D008823:Micelles; D019207:beta Carotene; D002338:Carotenoids; D008747:Methylcellulose; D014975:Lutein