title: Strontium oxide doped quaternary glasses: effect on structure, degradation and cytocompatibility.
abstract: This preliminary study focuses on the effect of adding SrO to a Ti-containing quaternary phosphate glass system denoted by P(2)O(5)-Na(2)O-CaO-TiO(2). The following four different glass compositions were manufactured: 0.5P(2)O(5)-0.17Na(2)O-0.03TiO(2)-(0.3-x)CaO-xSrO where x = 0, 0.01, 0.03 and 0.05. Structural characterisation revealed glass transition temperatures in the range 427-437 degrees C and the presence of sodium calcium phosphate as the dominant phase in all the glasses. Degradation and ion release studies conducted over a 15-day period revealed that the Sr-containing glasses showed significantly higher degradation and ion release rates than the Sr-free glass. Cytocompatibility studies performed over a 7-day period using MG63 cells showed that the addition of 5 mol% SrO yielded glasses with cell viability nearly equivalent to that observed for quaternary TiO(2) glasses.
authors.affiliation: Eastman Dental Institute, University College London, UK.
authors.forename: N J
authors.initials: NJ
authors.lastname: Lakhkar
authors.forename: E A
authors.initials: EA
authors.lastname: Abou Neel
authors.forename: V
authors.initials: V
authors.lastname: Salih
authors.forename: J C
authors.initials: JC
authors.lastname: Knowles
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D001673:Biodegradation, Environmental; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D003460:Crystallization; D005898:Glass / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents / Q000378:metabolism; D007477:Ions / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D010078:Oxazines / Q000378:metabolism; D010087:Oxides / Q000737:chemistry*; D044367:Phase Transition; D013324:Strontium / Q000737:chemistry*; D013696:Temperature; D014961:X-Ray Diffraction; D014966:Xanthenes / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D007202:Indicators and Reagents; D007477:Ions; D010078:Oxazines; D010087:Oxides; D014966:Xanthenes; C005843:resazurin; D013324:Strontium