[The repair of abdominal defects in rabbits with Parietex and Surgisis meshes abdominal wall].
BACKGROUND
In general surgery, the repair of abdominal wall hernias has a prominent place, and the indications and uses of meshes have increased due to better results.


OBJECTIVE
To compare the repair of induced abdominal wall defects with Parietex and Surgisis meshes, in direct contact with abdominal viscera (intraperitoneal mesh).


METHODS
For the experiments, were used 16 female young adult rabbits. Two full thickness triangular defects of 2 cm base by 2.5 cm high were created, lateral to the linea alba, one at each side. They were repaired with rectangular meshes of 3 cm base by 3.5 cm high, on the right side with Parietex mesh (polyester/collagen-polyethylenglycol-glycerol), and on the left side with Surgisis mesh (lyophilized porcine small bowel submucosa). The evaluation included clinical-surgical findings as well as histological and immunohistochemical parameters. Eight rabbits were subjected to euthanasia after 30 days, and the eight after 60 days.


RESULTS
Both meshes induced skin erosions, despite the varying levels of mesh undermining evaluated, no incisional hernia occurred. There were peritoneal adhesions to the surface of both types of meshes after 30 days and in a lower extent and intensity after 60 days. Meshes' shrinking correspond to 1/3 of the original size and Parietex caused less inflammatory process at the histologic evaluation. Deposition of collagen type I presented no significant difference between the meshes, but deposition of collagen type III was more intense after 60 days, in both groups. Regarding collagen's rearrangement, the production of MMP8 was higher on Parietex after 30 days, and MMP13 enzyme was increased after 60 days, in both meshes (significant only for Parietex).


CONCLUSIONS
Both meshes were efficient in the correction of abdominal wall defects, and with similar results, but Parietex presented less inflammatory process and greater amount of matrix-metalloproteinases MMP8 and MMP13 than Surgisis.
Baroncello
João Batista
JB
Trabalho realizado no Instituto de Pesquisas Médicas do Hospital Universitário Evangélico de Curitiba, Faculdade Evangélica do Paraná, Curitiba, PR. ipem@evangelico.org.br
Czeczko
Nicolau Gregori
NG
Malafaia
Osvaldo
O
Ribas-Filho
Jurandir Marcondes
JM
Nassif
Paulo Afonso Nunes
PA
Dietz
Andreas Ulrich
AU
D034861:Abdominal Wall / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D004195:Disease Models, Animal; D005260:Female; D046449:Hernia, Abdominal / Q000201:enzymology / Q000473:pathology / Q000601:surgery*; D007150:Immunohistochemistry; D053509:Matrix Metalloproteinase 13 / Q000378:metabolism; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism; D010537:Peritoneum / Q000201:enzymology / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D011817:Rabbits; D018709:Statistics, Nonparametric; D013526:Surgical Mesh / Q000009:adverse effects; D000267:Tissue Adhesions / Q000209:etiology; D014945:Wound Healing / Q000502:physiology
D001672:Biocompatible Materials; D053509:Matrix Metalloproteinase 13; D020784:Matrix Metalloproteinase 8