title: Clinical implications of molecular genetic aberrations in acute myeloid leukemia.
abstract: The role of different cytogenetic changes has been extensively evaluated in patients with acute myeloid leukemia (AML), and cytogenetic analysis of AML blasts is essential to form prognostic subgroups in order to stratify for the extent of therapy. Nevertheless, 40-45% of AML patients lack such cytogenetic markers, i.e., cytogenetically normal AML (CN-AML). In the past decade, different molecular aberrations were identified in AML and especially CN-AML can now be discriminated into certain prognostic subgroups. This review considers the latest advances to define the prognostic impact of molecular aberrations in AML and gives insights how such molecular markers can be applied for analysis of minimal residual disease. Furthermore, therapeutic implications as well as the potential role of new methodological techniques in analyzing expression patterns of AML blasts are discussed.
authors.affiliation: Department of Internal Medicine II, Universitätsklinikum, Jena, Germany. sebastian.scholl@med.uni-jena.de
authors.forename: Sebastian
authors.initials: S
authors.lastname: Scholl
authors.forename: Hans-Joerg
authors.initials: HJ
authors.lastname: Fricke
authors.forename: Herbert G
authors.initials: HG
authors.lastname: Sayer
authors.forename: Klaus
authors.initials: K
authors.lastname: Höffken
mesh_terms: D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics; D002869:Chromosome Aberrations; D020440:Gene Duplication; D005787:Gene Frequency; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality / Q000628:therapy*; D008967:Molecular Biology; D009363:Neoplasm Proteins / Q000235:genetics; D011379:Prognosis; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D016019:Survival Analysis; D025721:WT1 Proteins / Q000235:genetics; D051941:fms-Like Tyrosine Kinase 3 / Q000235:genetics
chemical_list: C442828:BAALC protein, human; D022762:CCAAT-Enhancer-Binding Proteins; C515848:CEBPA protein, human; D009363:Neoplasm Proteins; D025721:WT1 Proteins; C497970:FLT3 protein, human; D011505:Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3