A case report of tumor-induced osteomalacia: eight year followed-up.
Tumor-induced osteomalacia (TIO) is a rare but potentially curable disease. It is caused by excessive renal clearance ofphosphate induced by a substance secreted from the tumor Here, the authors report a Thai patient who presented with multiple pathologic fractures, low serum phosphorus, and low tubular maximum reabsorption of phosphorus/glomerular filtration rate (TmPO4/GFR). The clinical, biochemical and bone abnormalities improved 6 months after the surgery. Two years follow-up showed no recurrence of the disease. Physicians should be aware of this condition when encountering with adult onset osteomalacia.
Ratanasuwan
Tanaporn
T
Internal Medicine Unit, Lerdsin Hospital, Department of Medical Service, Ministry of Public Health, Bangkok 10500, Thailand.
Chetsurakarn
Somchai
S
Ongphiphadhanakul
Boonsong
B
Damrongkitchaiporn
Somneok
S
D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors; D005919:Glomerular Filtration Rate; D006393:Hemangiopericytoma / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D017674:Hypophosphatemia; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000503:physiopathology; D010018:Osteomalacia / Q000209:etiology* / Q000503:physiopathology; D012279:Rickets; D012307:Risk Factors
D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23