title: Chromone and chromanone glucosides from Hypericum sikokumontanum and their anti-Helicobacter pylori activities.
abstract: Chromone glucosides, takanechromones A-C (1, 2 and 5) and chromanone glucosides, named takanechromanones A and B (3 and 4), were isolated from the methanolic extracts of Hypericumsikokumontanum together with 27 known compounds. Their structures were established based on spectroscopic evidence. The isolated compounds and some chromone derivatives were assayed for antimicrobial activity against Helicobacter pylori and cytotoxicity against human cancer cell lines.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
authors.forename: Naonobu
authors.initials: N
authors.lastname: Tanaka
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Nakano
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Shibata
authors.forename: Tomihiko
authors.initials: T
authors.lastname: Higuchi
authors.forename: Michiko
authors.initials: M
authors.lastname: Sekiya
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Ikeshiro
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002867:Chromones / Q000737:chemistry* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D020902:Hypericum / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D002867:Chromones; D005960:Glucosides