title: Discovery of 2-(alpha-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS.
abstract: A series of 2-(alpha-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.
authors.affiliation: Cytopia Research Pty Ltd, 576 Swan Street, Richmond, VIC. 3121, Australia.
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Burns
authors.forename: Michael F
authors.initials: MF
authors.lastname: Harte
authors.forename: Xianyong
authors.initials: X
authors.lastname: Bu
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Fantino
authors.forename: Marilena
authors.initials: M
authors.lastname: Giarrusso
authors.forename: Max
authors.initials: M
authors.lastname: Joffe
authors.forename: Margarita
authors.initials: M
authors.lastname: Kurek
authors.forename: Fiona S
authors.initials: FS
authors.lastname: Legge
authors.forename: Pasquale
authors.initials: P
authors.lastname: Razzino
authors.forename: Stephen
authors.initials: S
authors.lastname: Su
authors.forename: Herbert
authors.initials: H
authors.lastname: Treutlein
authors.forename: Soo San
authors.initials: SS
authors.lastname: Wan
authors.forename: Jun
authors.initials: J
authors.lastname: Zeng
authors.forename: Andrew F
authors.initials: AF
authors.lastname: Wilks
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D008958:Models, Molecular; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D011719:Pyrazines; D016186:Receptor, Macrophage Colony-Stimulating Factor