Inhibition of pathogen adhesion to host cells by polysaccharides from Panax ginseng.
PG-F2 and PG-HMW from Panax ginseng are pectin-type polysaccharides and PG-HMW might be an arabinogalactan. They demonstrated strong anti-adhesive activities against oral and skin pathogens to host cell lines in a dose-dependent manner from 0.1 to 2.0 mg/ml. While enzymatic hydrolysis caused complete loss of anti-adhesive activities, partial hydrolysis produced oligosaccharides with anti-adhesive properties. PG-F2 and PG-HMW might have a selective anti-adhesive effect against certain pathogenic bacteria without adverse effects on commensal bacteria.
Lee
Ji-Hye
JH
Department of Food Technology, School of Life Sciences and Biotechnology, Korea University.
Shim
Jin Sun
JS
Chung
Mi-Sook
MS
Lim
Seung-Taik
ST
Kim
Kyung Hyun
KH
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001422:Bacterial Adhesion / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006868:Hydrolysis; D009844:Oligosaccharides / Q000494:pharmacology; D005894:Panax / Q000737:chemistry*; D010368:Pectins; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009844:Oligosaccharides; D011134:Polysaccharides; D010368:Pectins