title: Effect of extract of Benincasa hispida on oxidative stress in rats with indomethacin induced gastric ulcers.
abstract: This study was undertaken to determine the healing of ulcers induced by indomethacin due to antioxidant role of fruit extract of Benincasa hispida (Ashgourd) on ulcers in rats. Malondialdehyde (MDA) in RBC and antral homogenate was determined to measure tissue oxidation. Superoxide dismutase (SOD) in RBC and antral homogenate, plasma and homogenate vitamin C were estimated as measures of antioxidant defense. On induction of gastric ulcer, there was significant increase in SOD in RBC and homogenate levels and vitamin C in plasma. There was an apparent decrease in ulcer index in animals treated with fruit extract. There was significant decrease in MDA with concomitant decrease in SOD and vitamin C levels in the treated rats when compared to those not treated with fruit extract. Benincasa hispida has been shown to contain certain active principles like terpenes, flavanoid C--glycosides and sterols which have antioxidant effects. These probably inhibit gastric mucosal injury by scavenging the free radicals and repress production of SOD and vitamin C in these rats.
authors.affiliation: Department of Biochemistry, Centre for Basic Sciences, Kasturba Medical College, Bejai, Mangalore 575 004.
authors.forename: Beena V
authors.initials: BV
authors.lastname: Shetty
authors.forename: Albina
authors.initials: A
authors.lastname: Arjuman
authors.forename: Aparna
authors.initials: A
authors.lastname: Jorapur
authors.forename: Rajashree
authors.initials: R
authors.lastname: Samanth
authors.forename: Sudhir Kumar
authors.initials: SK
authors.lastname: Yadav
authors.forename: N
authors.initials: N
authors.lastname: Valliammai
authors.forename: Anna Deepthy
authors.initials: AD
authors.lastname: Tharian
authors.forename: K
authors.initials: K
authors.lastname: Sudha
authors.forename: Gayathri M
authors.initials: GM
authors.lastname: Rao
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D019662:Cucurbitaceae; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000378:metabolism; D007213:Indomethacin; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000897:Anti-Ulcer Agents; D000975:Antioxidants; D010936:Plant Extracts; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001205:Ascorbic Acid; D007213:Indomethacin