title: Label-free detection with the liquid core optical ring resonator sensing platform.
abstract: Optical label-free detection prevents the cost and complexity of fluorescence and radio labeling while providing accurate quantitative and kinetic results. We have developed a new optical label-free sensor called the liquid core optical ring resonator (LCORR). The LCORR integrates optical ring resonator sensors into the microfluidic delivery system by using glass capillaries with a thin wall. The LCORR is capable of performing refractive index detection on liquid samples, as well as bio/chemical analyte detection down to detection limits on the scale of pg/mm2 on a sensing surface.
authors.affiliation: Biological Engineering Department, University of Missouri-Columbia, Columbia, MO, USA.
authors.forename: Ian M
authors.initials: IM
authors.lastname: White
authors.forename: Hongying
authors.initials: H
authors.lastname: Zhu
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Suter
authors.forename: Xudong
authors.initials: X
authors.lastname: Fan
authors.forename: Mohammed
authors.initials: M
authors.lastname: Zourob
mesh_terms: D001704:Biopolymers / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D017022:Flow Injection Analysis / Q000295:instrumentation* / Q000379:methods; D008832:Microchemistry / Q000295:instrumentation* / Q000379:methods; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods; D055096:Optical Devices; D012031:Refractometry / Q000295:instrumentation* / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D014159:Transducers
chemical_list: D001704:Biopolymers