Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.
The Division of Lung Diseases of the National Heart, Lung, and Blood Institute (NHLBI) recently held a workshop to identify gaps in our understanding and treatment of childhood lung diseases and to define strategies to enhance translational research in this field. Leading experts with diverse experience in both laboratory and patient-oriented research reviewed selected areas of pediatric lung diseases, including perinatal programming and epigenetic influences; mechanisms of lung injury, repair, and regeneration; pulmonary vascular disease; sleep and control of breathing; and the application of novel translational methods to enhance personalized medicine. This report summarizes the proceedings of this workshop and provides recommendations for emphasis on targeted areas for future investigation. The priority areas identified for research in pediatric pulmonary diseases included: (1) epigenetic and environmental influences on lung development that program pediatric lung diseases; (2) injury, regeneration, and repair in the developing lung; (3) pulmonary vascular disease in children; (4) development and adaptation of ventilatory responses to postnatal life; (5) nonatopic wheezing: aberrant large airway development or injury?; (6) strategies to improve assessment, diagnosis, and treatment of pediatric respiratory diseases; and (7) predictive and personalized medicine for children.
Castro
Mario
M
Washington University School of Medicine, Medicine and Pediatrics, St. Louis, Missouri, USA.
Ramirez
Maria I
MI
Gern
James E
JE
Cutting
Garry
G
Redding
Greg
G
Hagood
James S
JS
Whitsett
Jeffrey
J
Abman
Steve
S
Raj
J Usha
JU
Barst
Robyn
R
Kato
Gregory J
GJ
Gozal
David
D
Haddad
Gabriel G
GG
Prabhakar
Nanduri R
NR
Gauda
Estelle
E
Martinez
Fernando D
FD
Tepper
Robert
R
Wood
Robert E
RE
Accurso
Frank
F
Teague
W Gerald
WG
Venegas
Jose
J
Cole
F Sessions
FS
Wright
Rosalind J
RJ
D035843:Biomedical Research / Q000458:organization & administration*; D006801:Humans; D009316:National Institutes of Health (U.S.); D010372:Pediatrics; D012120:Respiration Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D014481:United States