title: Protein-passivated Fe(3)O(4) nanoparticles: low toxicity and rapid heating for thermal therapy.
abstract: Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.
authors.affiliation: Department of Chemistry, University of Massachusetts, USA. E-mail: rotello@chem.umass.edu ; ; Tel: +413-545-2058.
authors.forename: Bappaditya
authors.initials: B
authors.lastname: Samanta
authors.forename: Haoheng
authors.initials: H
authors.lastname: Yan
authors.forename: Nicholas O
authors.initials: NO
authors.lastname: Fischer
authors.forename: Jing
authors.initials: J
authors.lastname: Shi
authors.forename: D Joseph
authors.initials: DJ
authors.lastname: Jerry
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello