A paradoxical reaction during antituberculosis therapy for congenital tuberculosis.
A paradoxical tuberculosis (TB) reaction is defined as the clinical or radiological worsening of pre-existing TB lesions or the development of new lesions during treatment. We treated a case of such a paradoxical reaction in a 21-day-old female infant who was diagnosed with congenital TB and was being treated with antituberculous drugs. The paradoxical reaction improved after additional treatment with corticosteroids. Therefore, corticosteroids might be useful to control paradoxical reactions in patients with congenital tuberculosis.
Park
Ji Ae
JA
Department of Pediatrics, School of Medicine, Pusan National University, Busan, Korea.
Park
Seong Shik
SS
Park
Su Eun
SE
D000995:Antitubercular Agents / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000472:pathogenicity*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000151:congenital* / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology*
D000995:Antitubercular Agents; D005938:Glucocorticoids; D011241:Prednisone