Effect of systemic intermittent administration of human parathyroid hormone (rhPTH[1-34]) on the resistance to reverse torque in rabbit tibiae.
The aim of this study was to evaluate the effect of intermittent administration of human parathyroid hormone [rhPTH (1-34)] on the removal torque of implants placed in rabbit tibiae. Twenty male New Zealand rabbits were submitted to implant surgery. Each animal received one machined screw-type implant (3.75 mm diameter x 8 mm length) in the proximal metaphysis of the right tibia. The rabbits were then divided into 2 groups: the test group (n = 10) received 6 microg/kg of rhPTH (1-34) subcutaneously in the dorsal region 3 days a week, and the control group (n = 10) received placebo. Removal torque was performed at 28 and 56 days after implant placement for both groups. The mean removal torque values at 28 days were 37.0 +/- 4.36 Ncm and 47.4 +/- 6.77 Ncm for control and test groups respectively (P < .05). At 56 days the reverse torque was 45.8 +/- 3.96 Ncm for the control group and 55.8 +/- 2.86 Ncm for the test group, indicating that the removal torque was significantly higher in the test groups (P < .05). These results demonstrated that intermittent treatment with rhPTH (1-34) enhanced the removal torque of implants in rabbit tibiae.
Corsini
Marcelo Soeiro
MS
Department of Peridontics and Implantology, School of Dentistry, University of Santo Amaro, São Paulo, Brazil.
Faraco
Fátima N
FN
Castro
Alessandra A Pereira
AA
Onuma
Tatiana
T
Sendyk
Wilson R
WR
Shibli
Jamil Awad
JA
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001863:Bone Screws; D015921:Dental Implants; D020878:Device Removal; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D016348:Osseointegration / Q000187:drug effects; D010919:Placebos; D011817:Rabbits; D011897:Random Allocation; D011994:Recombinant Proteins; D019379:Teriparatide / Q000008:administration & dosage / Q000627:therapeutic use*; D013977:Tibia / Q000187:drug effects*; D013997:Time Factors; D019415:Torque
D050071:Bone Density Conservation Agents; D015921:Dental Implants; D010919:Placebos; D011994:Recombinant Proteins; D019379:Teriparatide