Characterization of new HLA-B and -DRB1 alleles from Singapore.
Six novel alleles, three human leukocyte antigen (HLA)-B and three HLA-DRB1 alleles, are described. Five of the variants are single nucleotide substitutions from their most homologous allele, of which three result in amino acid changes (B*3572, *9509 and DRB1*1157) and two are silent substitutions (B*370103 and DRB1*150204). DRB1*0462 differs by three nucleotide substitutions that alter two amino acids.
Lazaro
A M
AM
Department of Oncology, Georgetown University Medical Center, Washington, DC 20057, USA.
Hwang
W Y K
WY
Yeoh
A E J
AE
Ng
J
J
Posch
P E
PE
D000483:Alleles; D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D015235:HLA-B Antigens / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D012846:Singapore
D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains