title: Sleep benefits subsequent hippocampal functioning.
abstract: Sleep before learning benefits memory encoding through unknown mechanisms. We found that even a mild sleep disruption that suppressed slow-wave activity and induced shallow sleep, but did not reduce total sleep time, was sufficient to affect subsequent successful encoding-related hippocampal activation and memory performance in healthy human subjects. Implicit learning was not affected. Our results suggest that the hippocampus is particularly sensitive to shallow, but intact, sleep.
authors.affiliation: Department of Sleep and Cognition, Netherlands Institute for Neuroscience, institute of Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The Netherlands. y.van.der.werf@nin.knaw.nl
authors.forename: Ysbrand D
authors.initials: YD
authors.lastname: Van Der Werf
authors.forename: Ellemarije
authors.initials: E
authors.lastname: Altena
authors.forename: Menno M
authors.initials: MM
authors.lastname: Schoonheim
authors.forename: Ernesto J
authors.initials: EJ
authors.lastname: Sanz-Arigita
authors.forename: José C
authors.initials: JC
authors.lastname: Vis
authors.forename: Wim
authors.initials: W
authors.lastname: De Rijke
authors.forename: Eus J W
authors.initials: EJ
authors.lastname: Van Someren
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*