[Effect of low doses of ionizing radiaton on the fractional content of mitochondrial proteins and mtDNA in Guerin's carcinoma].
The work is devoted to investigation of the influence of low doses of preliminary radiation on the fraction content, and oxidizing modification of mitochondrial proteins, unsolvable in 0.05 M sodium-phosphate buffer (11,5), and mtDNA fragmentation. That low-dose irradiation influence mostly manifests itself on the initial stages of tumor growth. It was established that tumor development is accompanied with the changes of mitochondrial proteins fraction content. These changes occured on the intensive oxidizing modification background of the proteins under study and mtDNA fragmentation.
Marchenko
M M
MM
Kopyl'chuk
H P
HP
Voloshchuk
O M
OM
D000818:Animals; D053938:DNA Fragmentation / Q000528:radiation effects; D004272:DNA, Mitochondrial / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D006863:Hydrogen-Ion Concentration; D008928:Mitochondria / Q000378:metabolism / Q000528:radiation effects*; D024101:Mitochondrial Proteins / Q000737:chemistry / Q000378:metabolism*; D008970:Molecular Weight; D009374:Neoplasms, Experimental / Q000378:metabolism*; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D051381:Rats; D012995:Solubility
D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins