title: Cathodic adsorptive stripping voltammetry of drotaverine hydrochloride and its determination in tablets and human urine by differential pulse voltammetry.
abstract: The stripping voltammetric behaviour of drotaverine hydrochloride (DvCl) was studied using a hanging mercury drop electrode (HMDE). The adsorptive stripping response has been evaluated with respect to pH, accumulation time, accumulation potential, scan rate and other variables. Differential pulse DP mode; over the potential range -400 to -1200 mV, is used in the presence of 0.04 M Britton-Robinson buffer pH 2. Cyclic voltammetric study indicates that the reduction process is irreversible and controlled by adsorption. The response of DP technique is linear over the concentration range 21.70-257.34 ng/ml. Limit of detection and limit of quantification were 3.15 and 10.50 ng/ml, respectively. The proposed method was successfully applied for the determination of the drug in commercial tablets and spiked human urine samples.
authors.affiliation: Faculty of Industrial Education, Beni Suef University, Beni Suef, Egypt. simam90@hotmail.com
authors.forename: S I M
authors.initials: SI
authors.lastname: Zayed
authors.forename: Y M
authors.initials: YM
authors.lastname: Issa
mesh_terms: D000327:Adsorption; D002138:Calibration; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010208:Papaverine / Q000031:analogs & derivatives* / Q000032:analysis / Q000652:urine; D013607:Tablets / Q000737:chemistry*
chemical_list: D013607:Tablets; C005317:drotaverin; D010208:Papaverine