Causal relationships between esophageal squamous cell carcinoma and nephrotic syndrome.
We present a case of membranous nephropathy (MN) associated with esophageal squamous cell carcinoma (ESCC) with a high serum level of squamous cell carcinoma antigen (SCC). ESCC reached complete response (CR) for radiotherapy, with a partial remission of the proteinuria and decreased serum SCC levels. Six months after radiotherapy, the ESCC recurred, and the patient was treated with endoscopic mucosal resection (EMR), achieving a pathologic CR and disappearance of proteinuria and normalized serum SCC levels. The correlation of proteinuria and the serum level of SCC indicates that SCC could be a pathogenic antigen, responsible for the pathogenesis of MN in this patient.
Muramoto
Takashi
T
The Second Department of Internal Medicine, Showa University School of Medicine, Tokyo.
Kaneko
Kazuhiro
K
Kuroki
Aki
A
Konishi
Kazuo
K
Ito
Hiroaki
H
Katagiri
Atsushi
A
Kubota
Yutaro
Y
Ohtsu
Atsushi
A
Imawari
Michio
M
D000951:Antigens, Neoplasm / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D004938:Esophageal Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D015843:Serpins / Q000097:blood
D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen