Exposing hidden dimensions of embryonic stem cell cycle control.
In a recent issue of Nature Genetics, Wang and colleagues (2008) describe a mechanism for how the mir-290 microRNA cluster regulates the cell cycle of murine embryonic stem cells. A focal point of this regulation is the cyclin-dependent kinase inhibitor p21(Cip1).
Dalton
Stephen
S
Department of Biochemistry and Molecular Biology, Paul D. Coverdell Center for Biomedical and Health Sciences, The University of Georgia, 500 D.W. Brooks Drive, Athens, GA 30602, USA. sdalton@uga.edu
D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D049109:Cell Proliferation; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism; D008954:Models, Biological
D035683:MicroRNAs