title: Chronic organophosphate (OP)-induced neuropsychiatric disorder is a withdrawal syndrome.
abstract: Chronic organophosphate-induced neuropsychiatric disorder is a less well-characterized syndrome, which is usually delay-occurred, persists long and is similar to the symptom of cholinergic deficit, its mechanism is unclear. The characteristics of chronic organophosphate-induced neuropsychiatric disorder are somewhat opposite to the direct action of OP pesticide, since withdrawal effect is usually opposite to the original effect of a drug, hypothesis that chronic organophosphate-induced neuropsychiatric disorder is a kind of withdrawal syndrome is suggested.
authors.affiliation: Evaluation and Research Center for Toxicology, Institute of Disease Control and Prevention, Academy of Military Medical Sciences, 20 Dong Da Jie Street, Fengtai District, Beijing 100071, PR China. tandehongsy@126.com
authors.forename: De-Hong
authors.initials: DH
authors.lastname: Tan
authors.forename: Shuang-Qing
authors.initials: SQ
authors.lastname: Peng
authors.forename: Ying-Liang
authors.initials: YL
authors.lastname: Wu
authors.forename: Yi-Mei
authors.initials: YM
authors.lastname: Wang
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Lu
authors.forename: Chang-Hui
authors.initials: CH
authors.lastname: Yan
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D013375:Substance Withdrawal Syndrome
chemical_list: D009943:Organophosphorus Compounds