Sleep benefits subsequent hippocampal functioning.
Sleep before learning benefits memory encoding through unknown mechanisms. We found that even a mild sleep disruption that suppressed slow-wave activity and induced shallow sleep, but did not reduce total sleep time, was sufficient to affect subsequent successful encoding-related hippocampal activation and memory performance in healthy human subjects. Implicit learning was not affected. Our results suggest that the hippocampus is particularly sensitive to shallow, but intact, sleep.
Van Der Werf
Ysbrand D
YD
Department of Sleep and Cognition, Netherlands Institute for Neuroscience, institute of Royal Netherlands Academy of Arts and Sciences, Meibergdreef 47, 1105BA Amsterdam, The Netherlands. y.van.der.werf@nin.knaw.nl
Altena
Ellemarije
E
Schoonheim
Menno M
MM
Sanz-Arigita
Ernesto J
EJ
Vis
José C
JC
De Rijke
Wim
W
Van Someren
Eus J W
EJ
D000368:Aged; D000375:Aging / Q000502:physiology; D004569:Electroencephalography; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D006801:Humans; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012894:Sleep Stages / Q000502:physiology*; D012893:Sleep Wake Disorders / Q000503:physiopathology*