title: Translational control of long-lasting synaptic plasticity and memory.
abstract: Long-lasting forms of synaptic plasticity and memory are dependent on new protein synthesis. Recent advances obtained from genetic, physiological, pharmacological, and biochemical studies provide strong evidence that translational control plays a key role in regulating long-term changes in neural circuits and thus long-term modifications in behavior. Translational control is important for regulating both general protein synthesis and synthesis of specific proteins in response to neuronal activity. In this review, we summarize and discuss recent progress in the field and highlight the prospects for better understanding of long-lasting changes in synaptic strength, learning, and memory and implications for neurological diseases.
authors.affiliation: Department of Biochemistry and McGill Cancer Center, McGill University, Montreal QCH3G1Y6, Canada. costamat@bcm.edu
authors.forename: Mauro
authors.initials: M
authors.lastname: Costa-Mattioli
authors.forename: Wayne S
authors.initials: WS
authors.lastname: Sossin
authors.forename: Eric
authors.initials: E
authors.lastname: Klann
authors.forename: Nahum
authors.initials: N
authors.lastname: Sonenberg
mesh_terms: D051701:Activating Transcription Factor 4 / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D008568:Memory / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology; D014176:Protein Biosynthesis; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D019893:Ribosomal Protein S6 Kinases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D058570:TOR Serine-Threonine Kinases; D039221:mRNA Cleavage and Polyadenylation Factors / Q000378:metabolism
chemical_list: D051701:Activating Transcription Factor 4; D002352:Carrier Proteins; D015852:Eukaryotic Initiation Factor-2; D051860:Fragile X Messenger Ribonucleoprotein 1; D035683:MicroRNAs; D011494:Protein Kinases; D012333:RNA, Messenger; D019893:Ribosomal Protein S6 Kinases; D058570:TOR Serine-Threonine Kinases; D039221:mRNA Cleavage and Polyadenylation Factors