title: Acute Chlamydia pneumoniae infection in the pathogenesis of autoimmune diseases.
abstract: Autoimmune diseases have several etiologies. Acute Chlamydia pneumoniae (C. pneumoniae) infection may be involved in the pathogenesis of several autoimmune diseases. In this study, 82 patients with several autoimmune diseases and 70 controls were enrolled, and acute C. pneumoniae infection has been evaluated by monitoring the levels of IgM antibody. Chlamydia pneumoniae IgM positive results were observed in 29% (P < 0.05) of the patients with several autoimmune diseases and in 10% of the controls. Chlamydia pneumoniae IgM positive cases were more frequent among the patients with rheumatoid arthritis (RA; 30%, P < 0.05), systemic lupus erythematosus (SLE; 28.0%, P < 0.05), dermatomyositis/polymyositis (23%, NS), myeloperoxidase-antineutrophil cytoplasmic autoantibody (MPO-ANCA)-associated vasculitis (33%, NS), adult onset of Still's disease (29%, NS) and giant cell arteritis/Takayasu arteritis (50%, NS) than among the controls. This positive frequency was statistically significant in RA and SLE. These results suggest that acute C. pneumoniae infection is probably involved in the pathogenesis of autoimmune diseases.
authors.affiliation: Department of Clinical Immunology and Rheumatology, Kitano Hospital, Tazuke Kofukai Medical Research Institute, Osaka, Japan. masaaki_fujita_masaaki_fujita@yahoo.co.jp
authors.forename: M
authors.initials: M
authors.lastname: Fujita
authors.forename: S
authors.initials: S
authors.lastname: Hatachi
authors.forename: M
authors.initials: M
authors.lastname: Yagita
mesh_terms: D001327:Autoimmune Diseases / Q000209:etiology* / Q000382:microbiology; D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000150:complications*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*
chemical_list: D007075:Immunoglobulin M