Deregulated EGFR signaling during lung cancer progression: mutations, amplicons, and autocrine loops.
Gazdar
Adi F
AF
Hamon Center for Therapeutic Oncology Research and the Simmons Cancer Center, UT Southwestern Medical Center, Dallas, Texas 75390-8593, USA. adi.gazdar@utsouthwestern.edu
Minna
John D
JD
D019898:Autocrine Communication / Q000235:genetics / Q000502:physiology; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D005784:Gene Amplification / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic; D018773:Genes, erbB-1; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000473:pathology; D008954:Models, Biological; D009154:Mutation / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics