title: A novel pro-apoptosis gene PNAS4 that induces apoptosis in A549 human lung adenocarcinoma cells and inhibits tumor growth in mice.
abstract: The gene PNAS4 is a high conservative gene that shares high homology of sequence in various organisms from plants to animals. We found overexpression of human PNAS4 induced apoptosis and arrested cell cycle in S phase in A549 human lung adenocarcinoma cells. In C57BL/6 mice model of Lewis lung carcinoma, overexpression of mouse PNAS4 significantly suppressed tumor growth and prolonged survival time through induction of tumor cell apoptosis, exhibiting effective antitumor. Our original investigations in vitro and vivo indicated PNAS4 is a novel pro-apoptosis gene, which could be used as a potential target of cancer biotherapy in future.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, Sichuan, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: Yan
authors.forename: Lantu
authors.initials: L
authors.lastname: Gou
authors.forename: Jinliang
authors.initials: J
authors.lastname: Yang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Chen
authors.forename: Aiping
authors.initials: A
authors.lastname: Tong
authors.forename: Minghai
authors.initials: M
authors.lastname: Tang
authors.forename: Zhu
authors.initials: Z
authors.lastname: Yuan
authors.forename: Shaohua
authors.initials: S
authors.lastname: Yao
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D019759:Carbon-Nitrogen Lyases; D018827:Carcinoma, Lewis Lung / Q000378:metabolism* / Q000473:pathology; D002453:Cell Cycle / Q000502:physiology; D045744:Cell Line, Tumor; D003001:Cloning, Molecular; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D014162:Transfection
chemical_list: D051017:Apoptosis Regulatory Proteins; C541601:PNAS4 protein, mouse; D019759:Carbon-Nitrogen Lyases; C000604991:DESI2 protein, human