title: Epidural idiopathic sterile pyogranulomatous inflammation causing spinal cord compressive injury in five Miniature Dachshunds.
abstract: OBJECTIVE
  To characterize the clinical signs, diagnostic and surgical findings, and outcome of dogs with idiopathic sterile pyogranulomatous inflammation (ISP) of epidural fat causing spinal cord compression.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Dogs (n=5).
  
  
  METHODS
  Dogs with epidural ISP (2002-2006) were identified retrospectively. Inclusion criteria were neurologic examination, myelography, and definitive diagnosis of ISP confirmed by surgery and histopathologic examination of epidural spinal cord compressive tissue.
  
  
  RESULTS
  The most common clinical sign was paraparesis/paraplegia. No abnormalities were detected by laboratory testing or survey spine radiographs. On myelography, extradural spinal cord compressions were focal (dogs 1, 3, and 5) or multifocal (dogs 2 and 4). Surgical decompression of the spinal cord was completed by hemilaminectomy. Epidural fat collected surgically had pyogranulomatous inflammation of unknown cause and was histologically similar to subcutaneous ISP. All dogs had good long-term neurologic outcome (10-45 months follow-up). Some dogs had episodes of ISP at other sites before or after surgical treatment of epidural ISP, suggesting there may be a systemic form of ISP.
  
  
  CONCLUSIONS
  Epidural ISP may cause a spinal cord compressive lesion in Miniature Dachshunds, which can be treated by surgical decompression of the spinal cord with or without administration of adjunctive steroids.
  
  
  CONCLUSIONS
  Epidural ISP should be considered as a possible cause of thoracolumbar myelopathy for Miniature Dachshunds.
authors.affiliation: Aikawa Veterinary Medical Center, Shinjuku-ku, Tokyo, Japan. taikawa@wb3.so-net.ne.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aikawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Yoshigae
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kanazono
mesh_terms: D000818:Animals; D001947:Breeding; D019299:Decompression, Surgical / Q000379:methods / Q000662:veterinary*; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D005260:Female; D008297:Male; D015434:Panniculitis / Q000150:complications / Q000601:surgery / Q000662:veterinary*; D012189:Retrospective Studies; D013117:Spinal Cord Compression / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D016896:Treatment Outcome