title: IDM release behavior and surface characteristics of the novel Cu/IDM/LDPE nanocomposite for intrauterine device.
abstract: Copper/indomethacin/low-density polyethylene (Cu/IDM/LDPE) nanocomposite was prepared as a novel material for intra-uterine device (IUD). IDM release profile of the nanocomposite was investigated by using spectrophotometer. The results show that IDM release rate of Cu/IDM/LDPE nanocomposite is higher in simulated uterine solution than that in methanol, confirming that the release process of IDM is dominated mainly by pore diffusion. The decrease in copper particle size and the increase in copper mass content all accelerate IDM release, indicating that IDM release rate can be adjusted by changing copper loading or copper particle size. The surface of the incubated nanocomposite was characterized by X-ray diffraction, scanning electron microscopy and energy dispersive X-ray microanalysis. A few deposits composed of P, Cl, Ca, Cu and O were observed on the nanocomposite surface, which may be related to the presence of IDM particles with large particle size.
authors.affiliation: China University of Geosciences, Wuhan, PR China.
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Yang
authors.forename: Changsheng
authors.initials: C
authors.lastname: Xie
authors.forename: Hua
authors.initials: H
authors.lastname: Xiang
authors.forename: Jinqing
authors.initials: J
authors.lastname: Feng
authors.forename: Xianping
authors.initials: X
authors.lastname: Xia
authors.forename: Shuizhou
authors.initials: S
authors.lastname: Cai
mesh_terms: D004058:Diffusion; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D007435:Intrauterine Devices, Copper; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry*; D010316:Particle Size; D020959:Polyethylene; D013499:Surface Properties; D014961:X-Ray Diffraction
chemical_list: D020959:Polyethylene; D007213:Indomethacin