Malondialdehyde, glutathione, and nitric oxide levels in Toxoplasma gondii seropositive patients.
The aim of this study was to investigate the difference in the serum malondialdehyde (MDA), glutathione (GSH), and nitric oxide (NO) levels between normal and T. gondii-infected patients. To this end, MDA, GSH, and NO levels in the sera of 37 seropositive patients and 40 participants in the control group were evaluated. In Toxoplasma ELISA, IgG results of the patient group were 1,013.0 +/- 543.8 in optical density (mean +/- SD). A statistically significant difference was found between patients and the control group in terms of MDA, GSH, and NO levels. A decrease in GSH activity was detected, while MDA and NO levels increased significantly. Consequently, it is suggested that the use of antioxidant vitamins in addition to a parasite treatment shall prove useful. The high infection vs control ratio of MDA and NO levels probably suggests the occurrence as a mechanism of tissue damage in cases of chronic toxoplasmosis. Moreover, it is recommended that the patient levels of MDA, GSH, and NO should be evaluated in toxoplasmosis.
Karaman
Ulku
U
Inonu University School of Medicine, Department of Parasitology, Malatya, Turkey.
Celik
Tuncay
T
Kiran
Tugba Raika
TR
Colak
Cemil
C
Daldal
Nilgun Ulfet
NU
D000818:Animals; D005978:Glutathione / Q000097:blood*; D006801:Humans; D007111:Immunity, Cellular; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood*; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress; D014122:Toxoplasma; D014123:Toxoplasmosis / Q000097:blood* / Q000276:immunology
D009569:Nitric Oxide; D008315:Malondialdehyde; D005978:Glutathione