The first Jacobson Lecture. Familial idiopathic intracranial hypertension.
BACKGROUND
Case reports of familial idiopathic intracranial hypertension (IIH) have appeared sporadically and infrequently.


METHODS
We reviewed the medical records of all patients with IIH seen at our institution to identify the number of familial cases.


RESULTS
Out of a cohort of 237 patients with IIH, we identified 27 members (25 women and 2 men) from 11 families, with IIH usually self-reported or reported by the index case. In 7 of the 11 families, the relationship was parent to child; in 4, it was sibling. Obesity was present in 85% of the family members.


CONCLUSIONS
Familial IIH appears to be more common than reported previously. A systematic evaluation of first-degree relatives may help to identify more cases. A study of the patterns of inheritance and associated co-morbidities may result in better understanding of the genetic issues with this disorder.
Corbett
James J
JJ
Department of Neurology, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA. jcorbett@neurology.umsmed.edu
D000293:Adolescent; D000328:Adult; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006261:Headache / Q000209:etiology; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D010211:Papilledema / Q000209:etiology; D015995:Prevalence; D011559:Pseudotumor Cerebri / Q000151:congenital / Q000175:diagnosis* / Q000453:epidemiology; D055815:Young Adult