title: Global versus local centrality in evolution of yeast protein network.
abstract: It is shown here that in the yeast protein interaction network the global centrality measure (betweenness) depends on the protein evolutionary age (i.e., on historic contingency) more weakly than the local centrality measure (degree). This phenomenon is not observed in mutational duplication-and-divergence models. The network domains responsible for this difference deal with DNA/RNA information processing, regulation, and cell cycle. A selection vector can operate in these domains, which integrates the network activity and thus compensates for the process of mutational divergence.
authors.affiliation: Institute of Cytology, Russian Academy of Sciences, St. Petersburg, Russia. aevin@mail.cytspb.rssi.ru
authors.forename: Alexander E
authors.initials: AE
authors.lastname: Vinogradov
mesh_terms: D030562:Databases, Protein; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000235:genetics* / Q000502:physiology; D005786:Gene Expression Regulation; D008957:Models, Genetic; D015233:Models, Statistical; D011110:Polymorphism, Genetic; D054730:Protein Interaction Domains and Motifs / Q000235:genetics*; D025941:Protein Interaction Mapping; D018709:Statistics, Nonparametric
chemical_list: D005656:Fungal Proteins