title: Photodynamic therapy for the treatment of a giant superficial basal cell carcinoma.
abstract: A 74-year-old man was referred to our department for the treatment of a 15 x 15 cm superficial basal cell carcinoma (BCC) on his lumbar region. As surgical excision was considered too destructive, photodynamic therapy (PDT) was proposed. Methyl 5-aminolevulinate (MAL) cream was applied under occlusion for 3 h before illumination with a light-emitting diode lamp with an emission peak of 632 nm, a fluence rate of 83.3 mW/cm, and a light dose of 37 J/cm. A second MAL-PDT session was repeated 1 week later. The neoplastic area healed in 30 days. No recurrence has occurred after a 40-month follow-up period, but clinical observation continues. Although surgery still remains the treatment of choice for giant BCC, for which the local invasiveness and metastatic potential are well known, we offered our patient the option of PDT because we believed that classical surgery could hardly provide the same satisfactory outcome. As far as we know, this is the first case of giant BCC treated with PDT.
authors.affiliation: Department of Dermatology, M. Bufalini Hospital, Cesena, Italy. dcalista@ausi-cesena.emr.it
authors.forename: Donato
authors.initials: D
authors.lastname: Calista
mesh_terms: D000368:Aged; D000622:Aminolevulinic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D010778:Photochemotherapy
chemical_list: C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid