title: Interleukin-18 promoter polymorphisms and the disease progression of Hepatitis B virus-related liver disease.
abstract: In this study, we aimed to explore whether interleukin-18 (IL-18) gene-promoter polymorphisms are associated with the outcome of hepatitis B virus (HBV) infection. In all, 204 chronically HBV-infected patients were recruited in this study. Of the 204 HBV-infected patients, 43 were considered to be inactive HBV carriers based on the sustained normalization of serum alanine aminotransferase (ALT) together with seropositivity for the antibody to hepatitis B e-antigen (anti-HBe). A total of 161 patients were found to have chronic progressive liver disease, which included cirrhosis. In these HBV-infected patients, the frequencies of AA genotype of IL-18 gene-promoter polymorphisms at position -607 and C allele at position -137 were significantly higher in inactive HBV carriers compared with those in patients with chronic progressive liver disease. These polymorphisms of the IL-18 promoter regions (-607 and -137) could be associated with different outcomes of HBV infection.
authors.affiliation: Clinical Research Center, NHO Nagasaki Medical Center, Kubara 2-1001-1, Omura 856-8652, Japan. migita@nmc.hosp.go.jp
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Migita
authors.forename: Kazumi
authors.initials: K
authors.lastname: Sawakami-Kobayashi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Maeda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Susumu
authors.initials: S
authors.lastname: Kondoh
authors.forename: Mika
authors.initials: M
authors.lastname: Sugiura
authors.forename: Ryoko
authors.initials: R
authors.lastname: Kawasumi
authors.forename: Osamu
authors.initials: O
authors.lastname: Segawa
authors.forename: Hideji
authors.initials: H
authors.lastname: Tajima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Machida
authors.forename: Minoru
authors.initials: M
authors.lastname: Nakamura
authors.forename: Koji
authors.initials: K
authors.lastname: Yano
authors.forename: Seigo
authors.initials: S
authors.lastname: Abiru
authors.forename: Eiji
authors.initials: E
authors.lastname: Kawasaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yatsuhashi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ishibashi
mesh_terms: D000328:Adult; D000368:Aged; D002353:Carrier State; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D020382:Interleukin-18