[Multipotent mesenchymal stromal cells from autologous bone marrow accelerate regeneration of refractory gastric ulcers].
In this article it was examined the application of autological multipotent mesenchymal stromal bone marrow cells (MMSC BM) for acceleration of gastric ulcers regeneration. Gastric ulcer in rats was induced by exposure to acetic acid according to the method of Okabe. It was shown, that the transplantation of MMSCs BM promoted the acceleration of gastric ulcers regeneration by reducing destructive-inflammation phase and activation of proliferative-reperation phase of regeneration process. This effect is connected with long-term (up to 30 days) realization of bioregulatory activity MMSCs BM, grafted into gastric ulcer zones. It was assumed that transplantation of MMSCs BM may be used as an alternative method of cell therapy of the chronic peptic ulcers.
Askarov
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D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D004195:Disease Models, Animal; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation / Q000379:methods; D039902:Multipotent Stem Cells / Q000637:transplantation*; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000628:therapy*; D014182:Transplantation, Autologous; D016896:Treatment Outcome