title: Effects of MPH-OROS on the organizational, time management, and planning behaviors of children with ADHD.
abstract: OBJECTIVE
  To evaluate the effects of stimulant medication on organizational, time management, and planning (OTMP) in children with attention-deficit/hyperactivity disorder (ADHD) and ascertain whether OTMP is normalized with medication.
  
  
  METHODS
  Participants included 19 stimulant-naïve children with ADHD (aged 8-13 years) and impaired OTMP functioning, defined as greater than 1 SD below norms on the Children's Organizational Skills Scale. A double-blind, placebo-controlled, crossover design, with 4 weeks of each condition, evaluated medication (methylphenidate-osmotic-release oral system [MPH-OROS]) effects on OTMP, based on the parent and teacher versions of the Children's Organizational Skills Scale. The parent and teacher Swanson, Nolan, and Pelham, Version IV, rating scales assessed ADHD symptoms. "Not impaired" in OTMP was defined as no longer meeting study entry criteria, and "not impaired" in ADHD symptoms was defined as having mean Swanson, Nolan, and Pelham, Version IV, scores of < or = 1.0.
  
  
  RESULTS
  MPH-OROS significantly improved children's OTMP behaviors. These improvements were correlated with significant reductions in ADHD symptoms. However, most of the children (61%) continued to show significant OTMP impairments on MPH-OROS.
  
  
  CONCLUSIONS
  The MPH-OROS reduced children's OTMP deficits, and these improvements were associated with improvements in ADHD symptoms. Some children remained impaired in OTMP even after effective stimulant treatment of ADHD symptoms. These youngsters may require other treatments that target OTMP deficits.
authors.affiliation: New York University Child Study Center, 215 Lexington Avenue, 14th Floor, New York, NY 10016, USA. howard.abikoff@nyumc.org
authors.forename: Howard
authors.initials: H
authors.lastname: Abikoff
authors.forename: Jenelle
authors.initials: J
authors.lastname: Nissley-Tsiopinis
authors.forename: Richard
authors.initials: R
authors.lastname: Gallagher
authors.forename: Maurizio
authors.initials: M
authors.lastname: Zambenedetti
authors.forename: Michael
authors.initials: M
authors.lastname: Seyffert
authors.forename: Roy
authors.initials: R
authors.lastname: Boorady
authors.forename: John
authors.initials: J
authors.lastname: McCarthy
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D018592:Cross-Over Studies; D004311:Double-Blind Method; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D017748:Time Management / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate