Effect of the oligo(ethylene glycol) group on the antioxidant activity of manganese salen complexes.
The synthesis and antioxidant activity of oligo(ethylene glycol)-modified manganese salen complexes are reported. Their SOD activities were similar and 2- to 3-fold more potent than the standard compound EUK-134. Their catalase-like activity was lower than that of EUK-134 in the initial conversion rate; however, some analogs exhibited a better catalytic turnover number.
Park
Wonchoul
W
Department of Chemistry, Sejong University, Kwang-Jin Ku, Kunja-Dong, 98, Seoul 143-747, Republic of Korea.
Lim
Dongyeol
D
D000975:Antioxidants / Q000737:chemistry*; D002374:Catalase; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D004492:Edetic Acid / Q000737:chemistry; D019855:Ethylene Glycol / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D020128:Inhibitory Concentration 50; D008345:Manganese / Q000737:chemistry*; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D009195:Peroxidase / Q000737:chemistry; D013997:Time Factors
D000975:Antioxidants; D008345:Manganese; D004492:Edetic Acid; D006861:Hydrogen Peroxide; D002374:Catalase; D009195:Peroxidase; D019855:Ethylene Glycol; D010100:Oxygen