Celiac disease.
OBJECTIVE
Recent advances in the clinical, epidemiological, genetic, and therapeutic aspects of celiac disease have made this condition a superb model of autoimmunity. This review will outline the most significant work that contributed to our current knowledge of the disease.


RESULTS
Celiac disease is not confined to the Caucasian population as previously believed; rather its prevalence is approximately 1% worldwide. In addition to the HLA genes, many other genes involved in innate and adaptive immunity, intestinal barrier regulation, and autoimmunity have been identified as integral genetic components of the disease. Based on this information and on a better understanding of celiac disease pathogenesis, novel therapies alternative to the gluten-free diet are currently in advanced phase of development.


CONCLUSIONS
The outcome of these new findings will most likely have a significant impact in clinical practice, including diagnosis and management of the disease. Furthermore, celiac disease can be used as a unique model to gain more insights on the pathogenesis of autoimmune diseases.
Catassi
Carlo
C
Mucosal Biology Research Center and Center for Celiac Research, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Fasano
Alessio
A
D015551:Autoimmunity; D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D003937:Diagnosis, Differential; D055050:Diet, Gluten-Free / Q000379:methods*; D020022:Genetic Predisposition to Disease; D014943:Global Health; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007421:Intestine, Small / Q000276:immunology / Q000473:pathology*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors
D007155:Immunologic Factors