[Biological activity of Ungernia victoris extract in the Escherichia coli CaCl2-transformation system in the presence of calcium channel modulators].
Furosemid and verapamil appear to have an effect on the yield of E. coli plasmid transformants according to their properties as calcium channel regulators in eukaryotes. It means that furosemid stimulates and verapamil inhibits transforming DNA penetration into competent cell. PHB/Ca2+ polyP complex does not function only as a channel for transforming DNA penetration but appears to be one of the targets for transformation blocking U. victoris extract.
Miriuta
A Iu
AIu
Pererva
T P
TP
D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000378:metabolism*; D002122:Calcium Chloride / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000378:metabolism; D005665:Furosemide / Q000494:pharmacology; D006885:Hydroxybutyrates / Q000378:metabolism; D015640:Ion Channel Gating / Q000187:drug effects; D019668:Liliaceae / Q000737:chemistry*; D008954:Models, Biological; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D011091:Polyesters / Q000378:metabolism; D011122:Polyphosphates / Q000378:metabolism; D014169:Transformation, Bacterial / Q000187:drug effects* / Q000235:genetics; D014700:Verapamil / Q000494:pharmacology; D000094122:Polyhydroxybutyrates
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002122:Calcium Chloride; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D005665:Furosemide; D006885:Hydroxybutyrates; D010936:Plant Extracts; D011091:Polyesters; D011122:Polyphosphates; D014700:Verapamil; C003182:poly-beta-hydroxybutyrate; D000094122:Polyhydroxybutyrates