[Vasotocin analogues increase protein excretion by the rat kidney].
Introduction in stomach of unanaesthetized healthy rats of 5 ml per 100 g BW water or an injection of 0.05-0.1 nmol per 100 g BW arginine vasotocin and its analogues led to increase of diuresis and urine protein excretion. Excretion of proteins increased from 132 +/- 78 to 365 +/- 80 microg at water loading (p < 0.01) and to 423 +/- 143 microg after injection 1-desamino-8-arginine vasotocin (p < 0.01). Direct dependence was revealed between increase of diuresis and renal protein excretion. At water loading and an injection of arginine vasotocin and its analogues, protein excretion reached close maximum values despite distinctions of force and the mechanism of diuretic effects of applied factors. The assumption was substantiated, that increase of renal protein excretion in both variants of experiments depends on change of conditions of protein filtration in glomerular apparatus of the kidney due to increasing of efferent arterioles tonus.
Kutina
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AV
Natochin
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IuV
D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D007678:Kidney Glomerulus / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014668:Vasotocin / Q000031:analogs & derivatives / Q000494:pharmacology*
D004232:Diuretics; D011506:Proteins; D014662:Vasoconstrictor Agents; D014668:Vasotocin