title: [Effect of ivabradin and clopidogrel on platelet hemostasis indices in patients with acute coronary syndrome without ST-segment elevation and with concurrent cardiac insufficiency].
abstract: The article shows results obtained from 146 patients with acute coronary syndrome without ST-segment elevation and with concurrent heart failure stage IIA. All patients had profound changes of the hemostasis system. The use in a complex therapy klopidogrel medication, inhibitor of ADP-induced platelets aggregation considerably benefits state of blood coagulation properties: increases prothrombin time, INR-International normalized relation and APTT (activated partial thromboplastin time), decreases prothrombin index and fibrinogen quantity. Selective inhibitor of heart sinus node, ivabradin (koraksan) does not influence on hemogram indices and has positive influence on the course of the disease by lowering heart contraction frequency.
authors.forename: V M
authors.initials: VM
authors.lastname: Miziuk
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D001552:Benzazepines / Q000008:administration & dosage / Q000627:therapeutic use*; D000077144:Clopidogrel; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D006333:Heart Failure / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D006339:Heart Rate / Q000187:drug effects / Q000235:genetics; D006801:Humans; D000077550:Ivabradine; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D001552:Benzazepines; D010975:Platelet Aggregation Inhibitors; D000077550:Ivabradine; D000077144:Clopidogrel; D013988:Ticlopidine