Amphotericin B removal by plasma exchange.
This case report adds pharmacokinetic knowledge regarding amphotericin B. Amphotericin B is highly protein bound. Plasma exchange removes 50-75% of a substance in plasma within 1-2 h, corresponding to an elimination half-life of 30-40 min. Amphotericin B reduction ratio by plasma exchange was 40% in this patient who had both liver and renal failure.
Lew
S Q
SQ
Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University, Washington, DC, USA. sqlew@gwu.edu
D000328:Adult; D000666:Amphotericin B / Q000097:blood*; D000935:Antifungal Agents / Q000097:blood*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D017093:Liver Failure / Q000378:metabolism*; D008297:Male; D010951:Plasma Exchange; D011485:Protein Binding; D011697:Purpura, Thrombotic Thrombocytopenic / Q000378:metabolism* / Q000628:therapy; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000378:metabolism*
D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B