title: High-dose misoprostol as an alternative therapy after failed medical abortion.
abstract: OBJECTIVE
  The aim of this study was to determine the complete abortion rate for the vaginal administration of high-dose misoprostol after a failed medical abortion.
  
  
  METHODS
  When their medical abortions failed after the conventional oral administration of mifepristone and misoprostol, participants then received 1,000 microg of misoprostol vaginally. The efficacy and side effects of this treatment were evaluated.
  
  
  RESULTS
  Twenty-seven women who failed to abort after the conventional administration of mifepristone and misoprostol were enrolled in this trial. Fourteen days after the vaginal administration of 1,000 microg misoprostol, the overall complete expulsion rate had reached 88.8% (24/27). Most adverse effects were mild to moderate and did not require treatment.
  
  
  CONCLUSIONS
  The vaginal administration of 1,000 microg misoprostol as a salvage therapy after a failed medical abortion appears to be a safe and highly effective alternative to surgical intervention.
authors.affiliation: Department of Obstetrics and Gynecology, Kuo General Hospital, Tainan, Taiwan.
authors.forename: Yiu-Tai
authors.initials: YT
authors.lastname: Li
authors.forename: Guang-Qiong
authors.initials: GQ
authors.lastname: Hou
authors.forename: Tien-Hui
authors.initials: TH
authors.lastname: Chen
authors.forename: Yi-Chih
authors.initials: YC
authors.lastname: Chu
authors.forename: Ta-Chin
authors.initials: TC
authors.lastname: Lin
authors.forename: Long-Ching
authors.initials: LC
authors.lastname: Kuan
authors.forename: Mau
authors.initials: M
authors.lastname: Lin
authors.forename: Shu-Feng
authors.initials: SF
authors.lastname: Huang
authors.forename: Fu-Min
authors.initials: FM
authors.lastname: Chen
authors.forename: Tsung-Cheng
authors.initials: TC
authors.lastname: Kuo
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000028:Abortion, Induced / Q000379:methods*; D000293:Adolescent; D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome; D014592:Uterine Hemorrhage
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol