title: Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis.
abstract: BACKGROUND
  A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina.
  
  
  METHODS
  Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG.
  
  
  METHODS
  Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel.
  
  
  RESULTS
  The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.
authors.affiliation: Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
authors.forename: Arnon
authors.initials: A
authors.lastname: Adler
authors.forename: Arnon
authors.initials: A
authors.lastname: Afek
authors.forename: Yair
authors.initials: Y
authors.lastname: Levy
authors.forename: Gad
authors.initials: G
authors.lastname: Keren
authors.forename: Jacob
authors.initials: J
authors.lastname: George
mesh_terms: D000328:Adult; D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout
chemical_list: D017152:Antibodies, Antiphospholipid