title: Changes in antimicrobial resistance among Salmonella enterica subspecies enterica serovar Pullorum isolates in China from 1962 to 2007.
abstract: There are few data available for the trends of antimicrobial resistance of Salmonella enterica subspecies enterica serovar Pullorum (S. Pullorum) in China and other parts of the world. Thus, the objective of this study was to evaluate the changes in antimicrobial resistance of S. Pullorum isolated from diseased chickens in China from 1962 to 2007. A total of 450 S. Pullorum isolates were tested for their susceptibility to 17 antimicrobials in a disk diffusion method. 39-95% of the isolates displayed a high level of resistance, particularly against ampicillin, carbenicillin, streptomycin, tetracycline, trimethoprim and sulfafurazole. Isolates exhibited increased resistance to carbenicillin, spectinomycin, trimethoprim, trimethoprim/sulfamethoxazole and nalidixic acid during the study period. Moreover, 56.2% of the isolates exhibited multiple drug resistance (MDR; resistance> or =4 antimicrobials) and showed an increasing trend between 1970-1979 and 2000-2007. Therefore, the results suggest that certain measures, including continued surveillance of antimicrobial resistance and the rational use of antimicrobials, are necessary and important in order to control the rapid increase in antimicrobial resistance in S. Pullorum.
authors.affiliation: Jiangsu Key Laboratory of Zoonosis, Yangzhou University, 12 East Wenhui Road, Yangzhou, Jiangsu 225009, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Pan
authors.forename: Xiaoquan
authors.initials: X
authors.lastname: Wang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Zhang
authors.forename: Shizhong
authors.initials: S
authors.lastname: Geng
authors.forename: Xiang
authors.initials: X
authors.lastname: Chen
authors.forename: Weijuan
authors.initials: W
authors.lastname: Pan
authors.forename: Qiuxia
authors.initials: Q
authors.lastname: Cong
authors.forename: Xuexian
authors.initials: X
authors.lastname: Liu
authors.forename: Xinan
authors.initials: X
authors.lastname: Jiao
authors.forename: Xiufan
authors.initials: X
authors.lastname: Liu
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002645:Chickens; D002681:China / Q000453:epidemiology; D024901:Drug Resistance, Multiple, Bacterial; D008826:Microbial Sensitivity Tests / Q000662:veterinary; D011201:Poultry Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D012189:Retrospective Studies; D012481:Salmonella Infections, Animal / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D019779:Salmonella enterica / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents