title: Effect of thymoptin on hemostasis and fibrinolysis in rats with experimental nephritis.
abstract: Immune nephritis in rats was induced by administration of nephrotoxic rabbit antiserum. The development of severe renal inflammation (proteinuria, edema, lipemia, increased erythrocyte sedimentation rate, and 30% mortality) was accompanied by hypercoagulation and inhibition of fibrinolysis. Repeated subcutaneous injections of thymoptin in a low dose of 0.1 microg/200 g (5 injections every other day) increased the severity of inflammation and prethrombotic state of the blood. Lengthening the period between injections (5 injections at 5-day intervals) was followed by a tendency toward attenuation of nephritis and correction of hypercoagulation. In healthy rats, thymoptin produced an opposite effect on hemostasis, which was manifested in moderate stimulation of fibrinolysis and hypocoagulation.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia.
authors.forename: L V
authors.initials: LV
authors.lastname: Podorolskaya
authors.forename: T N
authors.initials: TN
authors.lastname: Serebryakova
authors.forename: G V
authors.initials: GV
authors.lastname: Andreenko
authors.forename: A K
authors.initials: AK
authors.lastname: Raevskaya
mesh_terms: D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects* / Q000502:physiology; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D009393:Nephritis / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C065652:timoptin; D013947:Thymosin