[Comparative characteristics of some pharmacological models of chronic heart failure].
Effectiveness and informativity of various experimental pharmacological models of the chronic heart failure (CCF) in rats have been evaluated by means of ultrasonic cardiography. It has been established that isoproterenol (INN isoprenaline) (80 mg/kg, s.c., twice with an interval of 24 h) produces compensated CCF. Monocrotaline (single dose 60 mg/kg, i.p.) caused the development of pulmonary hypertension, right ventricle hypertrophy, and pronounced right ventricle failure in a fraction of experimental rats. Doxorubicin administration (cumulative doze 15 mg/kg, i.p., divided into 6 injections within 14 days) resulted in decreased left ventricle contractility, eccentric heart remodeling, and CCF development in most cases. Thus, the doxorubicin-induced disorder in rats can be considered the most effective pharmacological model of CCF, leading to the development of pronounced and progressive CCF in the majority of experimental animals.
Kazachenko
A A
AA
Okovityĭ
S V
SV
Kulikov
A N
AN
Gustaĭnis
K R
KR
Nagornyĭ
M B
MB
Shulenin
S N
SN
Erokhina
I L
IL
Emel'ianova
O I
OI
D000818:Animals; D002908:Chronic Disease; D004146:Dioxanes / Q000494:pharmacology*; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000494:pharmacology*; D004452:Echocardiography; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011091:Polyesters / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D004146:Dioxanes; D011091:Polyesters; C095495:glycolide E-caprolactone copolymer; D004317:Doxorubicin; D007545:Isoproterenol