title: Recurrence in early gastric cancer with lymph node metastasis.
abstract: BACKGROUND
  Early gastric cancer (EGC) has an excellent prognosis, but some patients with lymph node-positive disease will develop recurrence. In this study we investigated the risk factors for recurrence in this selected group of patients.
  
  
  METHODS
  The clinical and pathological records of 2368 patients who underwent gastrectomy for solitary EGC between 1980 and 1999 at the National Cancer Center Hospital, Tokyo, were examined. Two hundred and thirty-eight patients (10%) were lymph node-positive (positive for lymph node metastasis) and form the population of this study.
  
  
  RESULTS
  Nineteen (8%) of the 238 patients with lymph node-positive disease developed recurrence. The most common site of recurrence was lymph node (37%), followed by liver (21%). The interval between surgery and the detection of recurrence ranged from 3 to 98 months, with a median of 26 months. Multivariate analysis demonstrated that the number of metastatic nodes was an independent risk factor for recurrence. Patients with seven or more metastatic nodes had the highest rate of recurrence, at 38%.
  
  
  CONCLUSIONS
  The number of nodes positive for metastasis was the only independent risk factor for recurrence after curative surgery in patients with lymph node-positive early gastric cancer. These high-risk patients may obtain additional survival benefit if targeted with adjuvant chemotherapy.
authors.affiliation: Gastric Surgery Division, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Makoto
authors.initials: M
authors.lastname: Saka
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Katai
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukagawa
authors.forename: Rajwinder
authors.initials: R
authors.lastname: Nijjar
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sano
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000704:Analysis of Variance; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology / Q000556:secondary*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009360:Neoplastic Cells, Circulating; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000473:pathology*