title: Antimicrobial activity of stereoisomers of morinols a and B, tetrahydropyran sesquineolignans.
abstract: The antimicrobial activity of all stereoisomers of morinols A and B was tested. All stereoisomers of morinols A and B showed antifungal activity against Alternaria alternata, especially (-)-morinol B which showed the strongest activity. The natural component, (+)-morinol A, and unnatural stereoisomer, (7S,7'S,8R,8'R)-morinol B, showed antibacterial activity against the gram-positive bacteria, Bacillus subtilis and Listeria denitrificans.
authors.affiliation: Integrated Center for Sciences, Tarumi Station, Ehime University.
authors.forename: Koichi
authors.initials: K
authors.lastname: Akiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamauchi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Maruyama
authors.forename: Takuya
authors.initials: T
authors.lastname: Sugahara
authors.forename: Taro
authors.initials: T
authors.lastname: Kishida
authors.forename: Yojiro
authors.initials: Y
authors.lastname: Koba
mesh_terms: D000528:Alternaria; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D001412:Bacillus subtilis; D006094:Gram-Positive Bacteria; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008087:Listeria; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D017705:Lignans; D011714:Pyrans; C519741:morinol A; C519740:morinol B