A clinical comparative study of piperacillin and sulbactam/ampicillin in patients with community-acquired bacterial pneumonia.
OBJECTIVE
To evaluate the clinical usefulness of piperacillin (4 g/day) therapy for community-acquired pneumonia compared to sulbactam/ampicillin (6 g/day).


METHODS
A randomized prospective clinical study was conducted in patients with mild to severe community-acquired bacterial pneumonia.


RESULTS
The overall clinical efficiency of piperacillin therapy (4 g/day) in these patients (41/53=77.4%) was comparable to that of sulbactam/ampicillin therapy (6 g/day: efficiency rate: 33/49=67.3%), when each therapy was administered intravenously for 3-7 days. With regards to clinical efficiency based on disease severity, bacteriological efficiency, improvement in chest X-ray findings and adverse reactions, the two therapies were comparable, even though we found more efficiency for patients who had underlying diseases and there were also cost benefits in piperacillin therapy, compared with sulbactam/ampicillin therapy


CONCLUSIONS
The results suggested that piperacillin therapy has good efficiency and tolerability and that it may be highly effective, even in cases of pneumonia with underlying diseases. This regimen may thus serve as a first line treatment of community-acquired pneumonia.
Seki
Masafumi
M
Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki. seki@nagasaki-u.ac.jp
Higashiyama
Yasuhito
Y
Imamura
Yoshifumi
Y
Nakamura
Shigeki
S
Kurihara
Shintaro
S
Izumikawa
Koichi
K
Kakeya
Hiroshi
H
Yamamoto
Yoshihiro
Y
Yanagihara
Katsunori
K
Tashiro
Takayoshi
T
Kohno
Shigeru
S
D000368:Aged; D000369:Aged, 80 and over; D000667:Ampicillin / Q000008:administration & dosage*; D017714:Community-Acquired Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010878:Piperacillin / Q000008:administration & dosage*; D018410:Pneumonia, Bacterial / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D011446:Prospective Studies; D011859:Radiography; D013407:Sulbactam / Q000008:administration & dosage*
D000667:Ampicillin; D013407:Sulbactam; D010878:Piperacillin