title: Recurrence of pleomorphic adenoma of the parotid gland--predictive value of cadherin-11 and fascin.
abstract: The predictive value of cadherin-11, tenascin, fascin, and mucin-1 as markers for the likelihood of recurrence in pleomorphic adenoma of the parotid gland was examined. In this retrospective study we analysed 20 tumours from16 patients by immunohistochemistry. Staining intensities were measured using a semiquantitative scoring approach; localisation (tumour centre vs border) as well as clinical data were analysed and correlated with follow-up. Cadherin-11 was increased in recurrent tumours. However, no changes of fascin, tenascin or mucin-1 were observed. Cadherin-11 and fascin were increased in primary tumours of patients with later recurrence, with fascin upregulation restricted to the tumour border. In conclusion, cadherin-11 and fascin should be further analysed for their value as markers for later recurrence in pleomorphic adenoma. Our observations might reflect dysregulation of cellular pathways contributing to cellular dissemination, which might potentially result in later recurrence.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, Johannes Gutenberg University, Mainz, Germany. brieger@hno.klinik.uni-mainz.de
authors.forename: Juergen
authors.initials: J
authors.lastname: Brieger
authors.forename: Anne
authors.initials: A
authors.lastname: Duesterhoeft
authors.forename: Christoph
authors.initials: C
authors.lastname: Brochhausen
authors.forename: Jan
authors.initials: J
authors.lastname: Gosepath
authors.forename: C James
authors.initials: CJ
authors.lastname: Kirkpatrick
authors.forename: Wolf J
authors.initials: WJ
authors.lastname: Mann
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis*; D015820:Cadherins / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008840:Microfilament Proteins / Q000032:analysis*; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000473:pathology; D010306:Parotid Gland / Q000473:pathology*; D010307:Parotid Neoplasms / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D019063:Tenascin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D002352:Carrier Proteins; D008840:Microfilament Proteins; D018396:Mucin-1; D019063:Tenascin; C020324:fascin; C086960:osteoblast cadherin