title: Negative regulation of Toll-like receptor signaling pathway.
abstract: TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR signaling pathways.
authors.affiliation: Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Hu
authors.forename: Wei Wen
authors.initials: WW
authors.lastname: Deng
authors.forename: Bing
authors.initials: B
authors.lastname: Sun
mesh_terms: D025461:Feedback, Physiological; D006801:Humans; D007107:Immune System / Q000502:physiology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D051193:Toll-Like Receptors