title: Central motor conduction in brachial monomelic amyotrophy.
abstract: BACKGROUND
  Prevalence of subclinical involvement of motor pathways in clinically diagnosed Brachial Monomelic Amyotrophy (BMMA) is unknown.
  
  
  OBJECTIVE
  To determine the prevalence of subclinical involvement of central motor pathways in BMMA using transcranial magnetic stimulation.
  
  
  METHODS
  Prospective case-control study.
  
  
  METHODS
  Central motor conduction time (CMCT) was determined by 'F' wave method using figure-of-eight coil attached to Magstim 200 stimulator, in 17 patients with BMMA. Motor evoked potentials were recorded from first dorsal interosseous of the affected (AFF) and unaffected upper limbs (UNAFF) at rest and during partial contraction. Comparison was made with data from 10 healthy controls (CTRL).
  
  
  METHODS
  Descriptive analysis and Analysis of Variance (ANOVA).
  
  
  RESULTS
  Compared to controls, the mean CMCT of AFF was significantly prolonged, both at rest and contraction: (a) Rest: AFF-6.68+/-1.78 ms, UNAFF-6.36+/-1.16 ms, CTRL-5.71+/-1.02 ms; Fisher's PLSD for AFF vs. CTRL: P =0.037, (b) Contraction: AFF-5.78+/-1.62 ms, UAFF - 4.86+/-1.38 ms, CTRL-4.06+/-0.80 ms; Fisher's PLSD for AFF vs. CTRL; P =0.0002, AFF vs. UNAFF- P =0.044). Prolonged CMCT (>mean+2SD of controls) was observed in 29.4% of AFF and 6.25% of UNAFF at rest, and in 47.1% and 23.5% respectively during contraction.
  
  
  CONCLUSIONS
  Dysfunction of central motor pathways was observed in both affected and unaffected upper limbs of some patients with BMMA of upper limbs. The dysfunction was more pronounced during voluntary contraction. A larger study is needed to validate the significance of these findings.
authors.affiliation: Department of Neurology, National Institute of Mental Health and Neurosciences, Bangalore, India. palpramod@hotmail.com
authors.forename: Pramod K
authors.initials: PK
authors.lastname: Pal
authors.forename: Nalini
authors.initials: N
authors.lastname: Atchayaram
authors.forename: Gaurav
authors.initials: G
authors.lastname: Goel
authors.forename: Ebenezer
authors.initials: E
authors.lastname: Beulah
mesh_terms: D000293:Adolescent; D000328:Adult; D020968:Brachial Plexus Neuritis / Q000503:physiopathology*; D004525:Efferent Pathways / Q000503:physiopathology*; D004576:Electromyography; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009431:Neural Conduction / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D034941:Upper Extremity / Q000294:innervation / Q000502:physiology; D055815:Young Adult