[Characterization of the drug resistance spectrum of rifampicin-resistant M. tuberculosis to other first-line antituberculous drugs].
The spectrum of drug-resistance of rifampicin-resistant M. tuberculosis strains to other first-line antituberculous drugs was studied. Streptomycin resistance was found to be prevalent in the structure of monoresistance. Resistance to two agents--isoniazid and streptomycin--was more common in the structure of polyresistance; that to a combination of isoniazid, rifampicin, and streptomycin was seen in the structure of multidrug resistance. The rifampicin-resistant strains were also resistance to isoniazid and streptomycin in 95.1 and 98.7% of cases, respectively. Resistance to isoniazid, streptomycin, and ethambutol occurs more frequently when cytosine is substituted for thymidine (TCG-->TTG) in codon 513 of the rpoB gene.
Isakova
Zh T
ZhT
Goncharova
Z K
ZK
Aldashev
A A
AA
D000293:Adolescent; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D004269:DNA, Bacterial / Q000032:analysis; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D015995:Prevalence; D011379:Prognosis; D012293:Rifampin / Q000627:therapeutic use*; D012426:Russia / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology*
D000904:Antibiotics, Antitubercular; D004269:DNA, Bacterial; D012293:Rifampin