title: Antioxidants and lipid peroxidation in gestational diabetes--a preliminary study.
abstract: Increased free radical activity in gestational diabetes (GDM) can lead to a host of damaging and degenerative maternal and fetal complications. Hence antioxidant levels in blood of GDM mothers and cord blood were estimated. Erythrocyte glutathione (GSH), superoxide dismutase (SOD) and thiobarbituric acid reactive substances (TBARS), plasma vitamins C and E and serum total glutathione-S-transferase (GST), protein thiols and ceruloplasmin (Cp) were estimated spectrophotometrically in maternal blood of age matched controls and mothers with GDM and also in cord blood samples of the above. There was a significant increase in the erythrocytic GSH, serum total GST and protein thiols in GDM maternal blood when compared to controls whereas erythrocytic SOD exhibited a marked decrease in GDM cases. The changes in plasma vitamins C and E, Cp and erythrocytic TBARS in GDM were not significantly different from controls. Cord blood levels of protein thiols were also significantly increased in GDM. No significant changes were observed in the serum Cp and GST levels of the same. Hence, elevated glucose levels can induce oxidative stress in GDM mothers.
authors.affiliation: Department of Biochemistry, Kasturba Medical College and Hospital, Manipal 576 104.
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Dey
authors.forename: Preeti
authors.initials: P
authors.lastname: Gupta
authors.forename: Nimish Kumar
authors.initials: NK
authors.lastname: Acharya
authors.forename: Srinivasa Nageswara
authors.initials: SN
authors.lastname: Rao
authors.forename: Swagat
authors.initials: S
authors.lastname: Ray
authors.forename: Sanjiban
authors.initials: S
authors.lastname: Chakrabarty
authors.forename: Sharanya
authors.initials: S
authors.lastname: Ramprasad
authors.forename: Tina Ann
authors.initials: TA
authors.lastname: Kurian
authors.forename: Anatoli
authors.initials: A
authors.lastname: Mawroh
authors.forename: Aishwarya
authors.initials: A
authors.lastname: Kundu
authors.forename: Geetha
authors.initials: G
authors.lastname: Bhaktha
authors.forename: Christy Philip
authors.initials: CP
authors.lastname: Joseph
authors.forename: Pratap
authors.initials: P
authors.lastname: Kumar
authors.forename: Lavanya
authors.initials: L
authors.lastname: Rai
authors.forename: Anjali
authors.initials: A
authors.lastname: Rao
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D015227:Lipid Peroxidation; D018384:Oxidative Stress; D010865:Pilot Projects; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers