title: [Four cases of hematologic malignancy following radioactive iodine therapy for thyroid cancer].
abstract: Ionizing radiation including I(131) might produce chromosomal translocation, causing hematologic malignancy. The incidence of leukemia following radioactive iodine treatment for thyroid cancer has been reported to be approximately 0.1 to 2.0% in Western countries, whereas fewer cases have been reported in Korea. We hereby report four cases of secondary hematologic malignancy, who received iodine therapy for thyroid cancer after thyroidectomy: two cases of acute lymphoblastic leukemia with t(9;22)(q34;q11.2), a case of MDS with 5q deletion, and a case of MDS with normal karyotype. Three cases of hematologic malignancy have developed after cumulative dosage of less than 800 mCi. The treatment intervals in two cases were less than 12 months, and the other two cases had I(131) therapy only once. Assessment of causality using the Naranjo probability scale for adverse drug reactions showed that a 'possible' relationship existed between the use of I(131) and secondary hematologic malignancy in all of the four cases in this report.
authors.affiliation: Department of Laboratory Medicine, Korea Cancer Center Hospital, Seoul, Korea.
authors.forename: Mijeong
authors.initials: M
authors.lastname: Im
authors.forename: Jin Kyung
authors.initials: JK
authors.lastname: Lee
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
authors.forename: Seok Il
authors.initials: SI
authors.lastname: Hong
authors.forename: Hye Jin
authors.initials: HJ
authors.lastname: Kang
authors.forename: Im Il
authors.initials: II
authors.lastname: Na
authors.forename: Baek-Yeol
authors.initials: BY
authors.lastname: Ryoo
authors.forename: Gi Jeong
authors.initials: GJ
authors.lastname: Cheon
authors.forename: Ha Na
authors.initials: HN
authors.lastname: Lee
authors.forename: Yoon Hwan
authors.initials: YH
authors.lastname: Chang
mesh_terms: D000328:Adult; D002892:Chromosomes, Human, Pair 22; D002895:Chromosomes, Human, Pair 5; D002899:Chromosomes, Human, Pair 9; D005260:Female; D017353:Gene Deletion; D019337:Hematologic Neoplasms / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D007953:Leukemia, Radiation-Induced / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000235:genetics; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000235:genetics; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000235:genetics; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D013965:Thyroidectomy; D014178:Translocation, Genetic
chemical_list: D007457:Iodine Radioisotopes