Assessment of metabolic changes in the striatum of a rat model of parkinsonism: an in vivo (1)H MRS study.
Degeneration of the dopaminergic neurons of the substantia nigra pars compacta in Parkinson's disease induces an abnormal activation of the glutamatergic neurotransmission system within the basal ganglia network and related structures. The aim of this study was to use proton MRS to show metabolic changes in the striatum of 6-hydroxydopamine-lesioned rats, a rodent animal model of Parkinson's disease. Animals were examined before and after extensive lesioning of the nigral dopaminergic neurons and after acute administration of L-3,4-dihydroxyphenylalanine. No significant alterations in glutamate concentrations, assessed by the MR signal dominated by glutamate with minor contributions from glutamine and gamma-aminobutyric acid, could be measured. The total choline/total creatine ratio was found to be reduced in the striatum of the ipsilateral hemisphere.
Kickler
N
N
INSERM U836, Grenoble Institut des Neurosciences, BP 170, F-38042 Grenoble Cedex 9, France. Nils.Kickler@epfl.ch
Lacombe
E
E
Chassain
C
C
Durif
F
F
Krainik
A
A
Farion
R
R
Provent
P
P
Segebarth
C
C
Rémy
C
C
Savasta
M
M
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D010300:Parkinson Disease / Q000378:metabolism*; D011522:Protons; D051381:Rats; D017207:Rats, Sprague-Dawley
D011522:Protons