Live immunization against East Coast fever--current status.
The infection-and-treatment method (ITM) for immunization of cattle against East Coast fever has historically been used only on a limited scale because of logistical and policy constraints. Recent large-scale deployment among pastoralists in Tanzania has stimulated demand. Concurrently, a suite of molecular tools, developed from the Theileria parva genome, has enabled improved quality control of the immunizing stabilate and post-immunization monitoring of the efficacy and biological impact of ITM in the field. This article outlines the current status of ITM immunization in the field, with associated developments in the molecular epidemiology of T. parva.
Di Giulio
Giuseppe
G
VetAgro Tanzania Ltd, PO Box 13188, Arusha, Tanzania.
Lynen
Godelieve
G
Morzaria
Subhash
S
Oura
Chris
C
Bishop
Richard
R
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002417:Cattle; D010118:Oxytetracycline / Q000627:therapeutic use; D016052:Protozoan Vaccines / Q000191:economics / Q000276:immunology*; D013801:Theileriasis / Q000188:drug therapy / Q000191:economics / Q000276:immunology*
D000900:Anti-Bacterial Agents; D016052:Protozoan Vaccines; D010118:Oxytetracycline