title: Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle.
abstract: GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Associations between the GHSR gene polymorphism and the growth traits were revealed in Nanyang cattle. The mutations at nt456(G > A) and nt667(C > T) were complete linkage and located in exon 1 of the coding region of the GHSR gene. Least squares analysis revealed a significant statistical effect (P < 0.05) of the GHSR gene different genotypes on body weight and average daily gain at 6 months of age in Nanyang cattle. Individuals with GHSR-MM genotype showed higher body weight and average daily gain than individuals with GHSR-MN genotype.
authors.affiliation: College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Northwest A&F University, 712100 Yangling, Shaanxi, China. zhangbao_1983@yahoo.com.cn
authors.forename: Bao
authors.initials: B
authors.lastname: Zhang
authors.forename: Hong
authors.initials: H
authors.lastname: Chen
authors.forename: Yikun
authors.initials: Y
authors.lastname: Guo
authors.forename: Liangzhi
authors.initials: L
authors.lastname: Zhang
authors.forename: Miao
authors.initials: M
authors.lastname: Zhao
authors.forename: Xianyong
authors.initials: X
authors.lastname: Lan
authors.forename: Chunlei
authors.initials: C
authors.lastname: Zhang
authors.forename: Chuanying
authors.initials: C
authors.lastname: Pan
authors.forename: Shenrong
authors.initials: S
authors.lastname: Hu
authors.forename: Juqiang
authors.initials: J
authors.lastname: Wang
authors.forename: Chuzhao
authors.initials: C
authors.lastname: Lei
mesh_terms: D000818:Animals; D001835:Body Weight; D001947:Breeding; D002417:Cattle / Q000235:genetics* / Q000254:growth & development; D002681:China; D056726:Genetic Association Studies / Q000379:methods; D016018:Least-Squares Analysis; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D054440:Receptors, Ghrelin / Q000235:genetics*
chemical_list: D054440:Receptors, Ghrelin