title: Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.
abstract: We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.
authors.affiliation: Departments of Nuclear Medicine,Albert Einstein College of Medicine, Bronx, New York 10461, USA. edadacho@aecom.yu.edu
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Bryan
authors.forename: Zewei
authors.initials: Z
authors.lastname: Jiang
authors.forename: Xianchun
authors.initials: X
authors.lastname: Huang
authors.forename: Alfred
authors.initials: A
authors.lastname: Morgenstern
authors.forename: Frank
authors.initials: F
authors.lastname: Bruchertseifer
authors.forename: Rani
authors.initials: R
authors.lastname: Sellers
authors.forename: Arturo
authors.initials: A
authors.lastname: Casadevall
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Dadachova
mesh_terms: D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003453:Cryptococcosis / Q000382:microbiology / Q000473:pathology / Q000532:radiotherapy*; D003455:Cryptococcus neoformans / Q000528:radiation effects*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D011836:Radiation Tolerance; D016499:Radioimmunotherapy