title: Adolescent wilms tumor with intraspinal and bone metastases: a case report and the review of literature.
abstract: A 14-year-old girl was referred for a large tumor of the left kidney, with intraspinal and vertebral metastases. Left nephrectomy and intraspinal tumor resection were performed. The histology of both tumors was nephroblastoma with no anaplasia and favorable histology, and they were diagnosed as stage IV. The tumor bed and vertebras were irradiated. We started chemotherapy according to the DD-4A regimen of Japanese Wilms' Tumor Study Group. The vertebral metastasis was additionally irradiated. The patient has remained in disease-free remission for 45 months after the surgical resection. Intensive multimodality therapy including DD-4A regimen of National Wilms' Tumor Study can result in long-term disease-free remission.
authors.affiliation: Departments of General Surgical Science, Gunma University, Graduate School of Medicine, Gunma, Japan. reinawat5507@yahoo.co.jp
authors.forename: Reina
authors.initials: R
authors.lastname: Watanabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Suzuki
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Toki
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanazawa
authors.forename: Junko
authors.initials: J
authors.lastname: Hirato
authors.forename: Akihiro
authors.initials: A
authors.lastname: Morikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kuwano
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000556:secondary* / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D009367:Neoplasm Staging; D013125:Spinal Neoplasms / Q000556:secondary* / Q000628:therapy; D009396:Wilms Tumor / Q000556:secondary* / Q000628:therapy