Study of in vivo biocompatibility and dynamics of replacement of rat shin defect with porous granulated bioceramic materials.
Biocompatibility of porous granulated bioceramic materials (hydroxyapatite, beta-tricalcium phosphate, hydroxyapatite-b-tricalcium phosphate complex (80:20 wt%), carbonate-containing hydroxyapatite, and silicon-containing hydroxyapatite) was shown in a subcutaneous test on BDF1 mice. Dynamic (up to 8 months) observation showed gradual replacement of the granular substance with de novo forming bone tissue with hemopoiesis foci on a model of fenestral defect in the shin bone in Wistar rats. By the rate of resorption, the materials rank as follows: silicon-containing hydroxyapatite<hydroxyapatite<hydroxyapatite-beta-tricalcium phosphate<beta-tricalcium phosphate<carbonate-containing hydroxyapatite. The rate of resorption in bone tissue defect was significantly higher than in the subcutaneous test, but lagged behind (even for tricalcium phosphate and carbonate-containing hydroxyapatite) bone tissue formation de novo.
Chissov
V I
VI
P. A. Hertzen Moscow Oncological Institute, Rosmedtechnologies, Moscow, Russia.
Sviridova
I K
IK
Sergeeva
N S
NS
Frank
G A
GA
Kirsanova
V A
VA
Achmedova
S A
SA
Reshetov
I V
IV
Filjushin
M M
MM
Barinov
S M
SM
Fadeeva
I V
IV
Komlev
V S
VS
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism*; D002130:Calcium Phosphates / Q000737:chemistry / Q000378:metabolism; D002516:Ceramics / Q000737:chemistry / Q000378:metabolism*; D006882:Hydroxyapatites / Q000737:chemistry / Q000378:metabolism; D020007:Implants, Experimental; D008422:Materials Testing; D051379:Mice; D016062:Porosity; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000473:pathology*
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006882:Hydroxyapatites; C485817:beta-tricalcium phosphate