Immunohistochemical expression of the human sodium/iodide symporter distinguishes malignant from benign gastric lesions.
OBJECTIVE
Sodium/iodide symporter (NIS) is a transmembrane protein that mediates the transport of I(-). The aim was to evaluate the immunohistochemical expression of the human homolog of NIS (hNIS) in a wide spectrum of gastric lesions.


METHODS
Seventy-seven samples were stained immunohistochemically with a monoclonal antibody for hNIS, including 14 with normal gastric mucosa, 14 with chronic atrophic gastritis with foveolar hyperplasia, 15 with chronic atrophic gastritis with intestinal metaplasia, 6 with chronic atrophic gastritis with atypical regenerative hyperplasia, 8 with chronic atrophic gastritis with dysplasia, 15 with invasive adenocarcinoma, 3 with well-differentiated neuroendocrine tumor, and 2 with gastrointestinal stromal tumors (GISTs).


RESULTS
hNIS stained the basolateral cytoplasmic portion of foveolae in normal mucosa, in 13 cases of chronic atrophic gastritis with foveolar hyperplasia, and in only 1 case of regenerative atypical hyperplasia. hNIS was consistently absent in intestinal metaplasia, in dysplastic glands, and in the cells constituting invasive carcinoma, well-differentiated neuroendocrine tumors, and GIST.


CONCLUSIONS
It seems that lack of hNIS can be useful in distinguishing foveolar hyperplasia from dysplastic glands.
Farnedi
Anna
A
Section of Anatomic and Histopathology, Department of Haematology and Oncology, "L. and A. Seragnoli" University of Bologna, Bellaria Hospital, Italy.
Eusebi
Leonardo H
LH
Poli
Francesca
F
Foschini
Maria P
MP
D000230:Adenocarcinoma / Q000175:diagnosis / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D005757:Gastritis, Atrophic / Q000175:diagnosis* / Q000378:metabolism; D046152:Gastrointestinal Stromal Tumors / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000175:diagnosis / Q000378:metabolism; D008297:Male; D008679:Metaplasia / Q000175:diagnosis / Q000378:metabolism; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000175:diagnosis* / Q000378:metabolism; D011230:Precancerous Conditions / Q000378:metabolism / Q000473:pathology*; D013274:Stomach Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D027981:Symporters / Q000378:metabolism*; D000099209:Sodium-Iodide Symporters
D027981:Symporters; D000099209:Sodium-Iodide Symporters