Better adherence with once-daily antiretroviral regimens: a meta-analysis.
Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.
Parienti
Jean-Jacques
JJ
Department of Biostatistics and Clinical Research, Côte de Nacre University Hospital, Caen, France. parienti-jj@chu-caen.fr
Bangsberg
David R
DR
Verdon
Renaud
R
Gardner
Edward M
EM
D000818:Animals; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D055118:Medication Adherence; D016032:Randomized Controlled Trials as Topic
D019380:Anti-HIV Agents