Refractory nodular lymphocyte predominant Hodgkin lymphoma transformed to T-cell/histiocyte-rich B-cell lymphoma in an adolescent: salvage therapy with allogeneic bone marrow transplantation.
According to biologic features, there is a substantial "gray zone" between nodular lymphocyte predominant Hodgkin lymphomas (NLPHLs) (Poppema lymphomas) and T-cell/histiocyte-rich B-cell lymphomas (T/HRBCLs). Transformation from an NLPHL to a T/HRBCL can occur and is associated with a worsening of the prognosis. Here is described a case of a 16-year-old boy who presented with an NLPHL with features of T/HRBCL. Clinical evolution was complicated by 2 relapses leading to autologous and then to allogeneic bone marrow transplantation.
Couronné
Lucile
L
Pediatric Hematology and Oncology, Hôpital Charles Nicolle, Rouen, France.
Schneider
Pascale
P
Picquenot
Jean Michel
JM
Laberge
Sophie
S
Bastard
Christian
C
Vannier
Jean Pierre
JP
D000293:Adolescent; D016026:Bone Marrow Transplantation; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D006644:Histiocytes / Q000473:pathology*; D006689:Hodgkin Disease / Q000473:pathology* / Q000628:therapy; D006801:Humans; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000473:pathology* / Q000628:therapy; D016399:Lymphoma, T-Cell / Q000473:pathology* / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis; D016879:Salvage Therapy; D014184:Transplantation, Homologous