title: Reduced corpus callosum white matter microstructural integrity revealed by diffusion tensor eigenvalues in abstinent methamphetamine addicts.
abstract: The purpose of the current study was to determine whether abstinent methamphetamine (MA) abusers demonstrate differences in white matter (WM) integrity of the corpus callosum (CC) due to possible neurotoxic effects of long-term MA abuse, compared with control subjects. In addition to fractional anisotropy (FA), the eigenvalues of the diffusion ellipsoid were used to evaluate the microstructural source of abnormal change in abstinent MA abusers if there occurred a difference in white matter integrity of the CC between healthy controls and abstinent MA abusers. Results showed significantly reduced FA in the genu of the corpus callosum in MA-dependent subjects compared with controls. Furthermore, the eigenvalues offered a unique opportunity to assess the microstructural source of abnormal changes in the genu of the CC. The relationships between Wisconsin Card Sorting Test (WCST) performance and the values of tensor measures also suggest that altered myelination is a possible source of FA reduction observed in the genu of the CC in MA abusers.
authors.affiliation: Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea.
authors.forename: In-Sung
authors.initials: IS
authors.lastname: Kim
authors.forename: Yang-Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Hui-Jin
authors.initials: HJ
authors.lastname: Song
authors.forename: Jae-Jun
authors.initials: JJ
authors.lastname: Lee
authors.forename: Do-Hoon
authors.initials: DH
authors.lastname: Kwon
authors.forename: Hui Joong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Myoung-Nam
authors.initials: MN
authors.lastname: Kim
authors.forename: Done-Sik
authors.initials: DS
authors.lastname: Yoo
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Chang
mesh_terms: D000328:Adult; D019969:Amphetamine-Related Disorders / Q000378:metabolism / Q000473:pathology* / Q000523:psychology; D003337:Corpus Callosum / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D011581:Psychological Tests
chemical_list: D008694:Methamphetamine