title: Clinical significance, angiographic characteristics, and short-term outcomes in 30 patients with early coronary artery graft failure.
abstract: BACKGROUND
  Despite technical advances in coronary artery bypass grafting (CABG), early postoperative myocardial ischaemia still remains a challenging problem. The aim of this study was to determine the incidence, clinical features, angiographic characteristics, and management of early graft failure in the present CABG era.
  
  
  METHODS
  Between January 1997 and December 2002, 1731 patients underwent CABG at our institution. Coronary angiography was performed in patients with clinical evidence of early postoperative ischaemia (</=3 months). Thirty of these patients with graft failure constituted the population of this study.
  
  
  RESULTS
  Off-pump and on-pump CABG were almost evenly performed in these patients [n=16 (53%) and n=14 (47%) respectively]. Acute myocardial infarction and unstable angina were the leading indications for coronary angiography in the majority of patients [n=28 (93%)]. The most common cause of graft failure was occlusion / thrombosis [n=20 (67%)]. Percutaneous coronary intervention (PCI) was offered to the majority of patients [n=22 (73%)]. Of these patients, 14 underwent PCI to native coronary arteries, whereas eight underwent PCI to the culprit vessel. Three patients underwent reoperation, and five received medical management. Four patients (13%) died in hospital (two after redo CABG, one after unsuccessful PCI, and one patient managed medically). Two patients (7%) had nonfatal major complications (one non-ST-elevation myocardial infarction and one stroke).
  
  
  CONCLUSIONS
  Early graft failure generally presents as acute coronary syndrome. Graft occlusion/ thrombosis is the leading cause of ischaemia. Patients with graft failure can undergo PCI with a relatively low risk, but the need for redo CABG in associated with a high mortality. (Neth Heart J 2009;17:13-7.).
authors.affiliation: Division of Cardiology, Texas Heart Institute, St Lukes Episcopal Hospital, Houston, Texas, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Virani
authors.forename: M
authors.initials: M
authors.lastname: Alam
authors.forename: C E
authors.initials: CE
authors.lastname: Mendoza
authors.forename: H
authors.initials: H
authors.lastname: Arora
authors.forename: A C
authors.initials: AC
authors.lastname: Ferreira
authors.forename: E
authors.initials: E
authors.lastname: de Marchena