[Progress in the studies on small molecule IGF-1R inhibitors].
The importance of insulin-like growth factor 1 receptor (IGF-1R) signaling in malignant behaviour of tumour cells is well established. Inhibiting the activity of IGF-1R may result in striking apoptosis in malignant cells growing. IGF-1R antibodies which are currently in phase I and II clinical trials and several IGF-IR TKIs have preclinically been characterized. This review describes recent developments of small molecule tyrosine kinase inhibitors.
Xu
Yan
Y
Department of Medicinal Chemistry, School of Pharmacy, Jilin University, Changchun 130021, China.
Wang
Guang-shu
GS
Sun
Wei
W
Yang
Xiao-hong
XH
Xu
Li-bao
LB
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001562:Benzimidazoles / Q000494:pharmacology; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D009369:Neoplasms / Q000473:pathology*; D010879:Piperazines / Q000494:pharmacology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D011728:Pyridones / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D017526:Receptor, IGF Type 1 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction
C504983:BMS 536924; C507943:BMS-554417; D001562:Benzimidazoles; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011728:Pyridones; D011743:Pyrimidines; D011758:Pyrroles; D002392:Catechin; C045651:epigallocatechin gallate; D017526:Receptor, IGF Type 1; C502355:NVP ADW742