title: Vanishing bile duct syndrome and Hodgkin disease: a case series and review of the literature.
abstract: This is the first description in which the diagnosis of vanishing bile duct syndrome (VBDS) preceded the diagnosis of Hodgkin disease (HD) by several months, and for which patients received modifications to modern MOPP-ABV chemotherapy with successful clinical remission. VBDS is an uncommon form of liver disease manifested by severe cholestasis and progressive liver failure. We report 2 cases of stage IIIB pediatric HD and VBDS. Because VBDS is progressive and the only curative treatment is liver transplant, it is imperative to recognize that children with VBDS may also have concurrent HD.
authors.affiliation: Texas Children's Cancer Center, USA. akpass@txccc.org
authors.forename: Amy Kun
authors.initials: AK
authors.lastname: Pass
authors.forename: Valerie A
authors.initials: VA
authors.lastname: McLin
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Rushton
authors.forename: Debra L
authors.initials: DL
authors.lastname: Kearney
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Hastings
authors.forename: Judith F
authors.initials: JF
authors.lastname: Margolin
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D002648:Child; D002779:Cholestasis / Q000175:diagnosis* / Q000188:drug therapy; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000627:therapeutic use; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D012074:Remission Induction; D013577:Syndrome; D016896:Treatment Outcome; D014747:Vinblastine / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D014747:Vinblastine; D004317:Doxorubicin; D011241:Prednisone