title: TiO(2) printed aluminum foil: single-use film for a laser desorption/ionization target plate.
abstract: Single-use aluminum foil-based laser desorption/ionization (LDI) target plates have been developed for mass spectrometry (MS) analysis and provide detection results comparable to those of commercial stainless steel plates while offering a convenient way to avoid the time-consuming surface cleaning process. Additionally, arrays of TiO(2) nanoparticle spots are coated on the foil either by screen-printing or rotogravure-printing followed by sintering to form a mesoporous layer spot to act as an anchor for sample deposition. These TiO(2) spots offer further functions to the Al foil, such as matrix-free laser desorption/ionization or specific affinity for in situ enrichment of phosphopeptides. The single-use TiO(2)-Al foils are cheap to produce, easy to use, and well suited for high-throughput proteomics research. They can also be of interest for protein post-translational modifications study.
authors.affiliation: Laboratoire d'Electrochimie Physique et Analytique, Ecole Polytechnique Federale de Lausanne, Station 6, CH-1015 Lausanne, Switzerland.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Bi
authors.forename: Liang
authors.initials: L
authors.lastname: Qiao
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Busnel
authors.forename: Valerie
authors.initials: V
authors.lastname: Devaud
authors.forename: Baohong
authors.initials: B
authors.lastname: Liu
authors.forename: Hubert H
authors.initials: HH
authors.lastname: Girault
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D000595:Amino Acid Sequence; D000809:Angiotensins / Q000032:analysis; D002364:Caseins / Q000032:analysis; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry*; D008969:Molecular Sequence Data; D009211:Myoglobin / Q000032:analysis; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000809:Angiotensins; D002364:Caseins; D009211:Myoglobin; C009495:titanium dioxide; D000535:Aluminum; D014025:Titanium