Identification of the novel allele HLA-B*4076 by sequence-based typing in a Chinese individual.
A novel human leukocyte antigen-B allele, officially named B*4076 allele, was found in a potential Chinese bone marrow donor when direct sequence-based typing was carried out. The novel B*4076 is identical to B*400101 with an exception of one base substitution at position 239(C>A)of exon 2 resulting in codon #80 changed from AAC (Asn) to AAA (Lys).
Li
S-Y
SY
Tissue Typing Laboratory, Tianjin Blood Center, Nankai District, Tianjin, China.
Xie
J-H
JH
Dong
L
L
Yan
L-N
LN
Yuan
Y-H
YH
D000483:Alleles; D019943:Amino Acid Substitution; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D001853:Bone Marrow; D002681:China; D015235:HLA-B Antigens / Q000235:genetics*; D059947:HLA-B40 Antigen; D006801:Humans; D019520:Living Donors; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D015235:HLA-B Antigens; C538921:HLA-B*40:76 antigen; D059947:HLA-B40 Antigen