title: Pioglitazone and the risk of myocardial infarction and other major adverse cardiac events: a meta-analysis of randomized, controlled trials.
abstract: A recent meta-analysis suggested that the use of rosiglitazone increases the risk of myocardial infarction (MI) in patients with type 2 diabetes mellitus. It is unclear whether this is a class effect of thiazolidinediones (TZD). We did a meta-analysis to evaluate cardiovascular outcomes with the use of pioglitazone. Randomized, controlled trials in which pioglitazone was compared with placebo or other hypoglycemic agents were considered for analysis. Studies were included if the data for MI were available. Studies were identified with use of relevant search words in Medline, Pubmed, EMBASE, CINAHL, and Cochrane databases. Data abstraction was done by 2 individual authors using a standardized protocol. The relative risk across all study groups was computed by the Mantel-Haenszel method, and interstudy heterogeneity was assessed by the chi method. All results were computed according to 95% confidence intervals. Five trials (N = 9965) met the inclusion criteria for analysis. The relative risk for MI was 0.86 (0.69-1.07; P = 0.17). The relative risks for stroke and revascularization were 0.79 (0.61-1.02; P = 0.07) and 0.40 (0.13-1.23; P = 0.11), respectively. Pioglitazone does not increase the risk for MI and may decrease the risk for stroke and revascularization.
authors.affiliation: Division of Cardiology, Department of Medicine, Rosalind Franklin University of Medicine and Science, North Chicago, IL, USA. nagapradeepnagajothi@yahoo.com
authors.forename: Nagapradeep
authors.initials: N
authors.lastname: Nagajothi
authors.forename: Sasikanth
authors.initials: S
authors.lastname: Adigopula
authors.forename: Saravanan
authors.initials: S
authors.lastname: Balamuthusamy
authors.forename: Jose-Luis E
authors.initials: JL
authors.lastname: Velazquez-Cecena
authors.forename: Kalpana
authors.initials: K
authors.lastname: Raghunathan
authors.forename: Ahmad
authors.initials: A
authors.lastname: Khraisat
authors.forename: Sarabjeet
authors.initials: S
authors.lastname: Singh
authors.forename: Janos
authors.initials: J
authors.lastname: Molnar
authors.forename: Sandeep
authors.initials: S
authors.lastname: Khosla
authors.forename: Daniel
authors.initials: D
authors.lastname: Benatar
mesh_terms: D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000401:mortality; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D009203:Myocardial Infarction / Q000139:chemically induced*; D000077205:Pioglitazone; D018570:Risk Assessment; D045162:Thiazolidinediones / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077205:Pioglitazone