title: Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis.
abstract: OBJECTIVE
  Colonoscopy plays an integral role in the diagnosis, management and surveillance of ulcerative colitis (UC). In the present study we assessed the relationship between endoscopic and histological findings, clinical symptoms, and laboratory data.
  
  
  METHODS
  We performed total colonoscopy examinations in 54 consecutive patients with UC. Seven segments (appendiceal region, cecum, ascending colon, transverse colon, descending colon, sigmoid colon, and rectum) were scored for endoscopic and histological activity. The patients were also evaluated using a symptom-activity index and laboratory markers: C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and white blood cell (WBC) and platelet (plt) counts.
  
  
  RESULTS
  There was a significant positive correlation between endoscopic and histological scores (r(s)=0.738), and between symptom activity score, endoscopic score (r(s)=0.444), and histological score (r(s)=0.557). Although the endoscopic and histological scores of distal colonic lesions (rectum-sigmoid, endoscopic: r(s)=0.515, histological: r(s)=0.624) correlated with clinical symptoms, there was no similar correlation for the proximal colon (appendiceal region-descending; endoscopic, r(s)=0.268, histological, r(s)=0.329). CRP, ESR, and WBC count also correlated with the sum of endoscopic and histological scores (CRP, r(s)=0.447, r(s)=0.369; ESR, r(s)=0.483, r(s)=0.589; WBC, r(s)=0.338, r(s)=0.330), whereas platelet count did not (r(s)=0.171, r(s)=0.210). In particular, CRP and ESR were well correlated with the activity of proximal colonic lesions (CRP, r(s) = 0.474, r(s)=0.480; ESR, r(s) = 0.423, r(s)=0.529) rather than with that of distal lesions (CRP, r(s)=0.236, r(s)=0.212; ESR, r(s)=0.368, r(s)=0.497).
  
  
  CONCLUSIONS
  In this study, clinical symptoms reflected the activity of distal colonic lesions, whereas CRP and ESR reflected the activity of proximal lesions. Therefore, total colonoscopy may be indicated when CRP or ESR is elevated in UC patients in clinical remission.
authors.affiliation: Department of Gastroenterology, Jutendo University School of Medicine, Bunkyo-ku, Tokyo, Japan. otaro@med.juntendo.ac.jp
authors.forename: Taro
authors.initials: T
authors.lastname: Osada
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Ohkusa
authors.forename: Isao
authors.initials: I
authors.lastname: Okayasu
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Yoshida
authors.forename: Shu
authors.initials: S
authors.lastname: Hirai
authors.forename: Kazuko
authors.initials: K
authors.lastname: Beppu
authors.forename: Tomoyoshi
authors.initials: T
authors.lastname: Shibuya
authors.forename: Naoto
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Kobayashi
authors.forename: Akihito
authors.initials: A
authors.lastname: Nagahara
authors.forename: Takeshi
authors.initials: T
authors.lastname: Terai
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis*; D003093:Colitis, Ulcerative / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D003106:Colon / Q000473:pathology*; D003113:Colonoscopy; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein