title: The Rcs two-component system regulates expression of lysozyme inhibitors and is induced by exposure to lysozyme.
abstract: The Escherichia coli Rcs regulon is triggered by antibiotic-mediated peptidoglycan stress and encodes two lysozyme inhibitors, Ivy and MliC. We report activation of this pathway by lysozyme and increased lysozyme sensitivity when Rcs induction is genetically blocked. This lysozyme sensitivity could be alleviated by complementation with Ivy and MliC.
authors.affiliation: Laboratory of Food Microbiology and Leuven Food Science and Nutrition Research Center, Katholieke Universiteit Leuven, Kasteelpark Arenberg 22, B-3001 Leuven, Belgium.
authors.forename: Lien
authors.initials: L
authors.lastname: Callewaert
authors.forename: Kristof G A
authors.initials: KG
authors.lastname: Vanoirbeek
authors.forename: Ine
authors.initials: I
authors.lastname: Lurquin
authors.forename: Chris W
authors.initials: CW
authors.lastname: Michiels
authors.forename: Abram
authors.initials: A
authors.lastname: Aertsen
mesh_terms: D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism; D029968:Escherichia coli Proteins / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D009113:Muramidase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D018085:Regulon; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; C429555:Ivy protein, E coli; C515605:MliC protein, E coli; C078611:rcsF protein, E coli; C074889:RcsB protein, Bacteria; D009113:Muramidase