The asymmetric total synthesis of (-)-securinine.
The alkaloid (-)-securinine was synthesized in 18 steps and 16% overall yield from trans-4-hydroxy-l-proline.
Dhudshia
Bhartesh
B
Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario, CanadaN9B 3P4.
Cooper
Benjamin F T
BF
Macdonald
Charles L B
CL
Thadani
Avinash N
AN
D001381:Azepines / Q000138:chemical synthesis*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D013237:Stereoisomerism
D001381:Azepines; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D010880:Piperidines; C000785:securinine