title: In-vitro myoglobin clearance by a novel sorbent system.
abstract: Rhabdomyolysis may lead to acute kidney injury following deposition of myoglobin in renal tubules. Although high-flux dialysis membranes may remove a substantial amount of myoglobin from plasma, this may still not be sufficient to prevent renal damage. We tested a new polymer sorbent, X-Sorb, in vitro to determine its potential to clear myoglobin from solutions. Normal saline or human serum in which myoglobin was dissolved was perfused by a peristaltic pump through a column packed with the sorbent. After a 4-hour perfusion, the myoglobin level in normal saline fell from 200,000 ng/ml to virtually undetectable (<780 ng/ml). Perfusion through the sorbent was then found to lower concentrations of dissolved myoglobin in 3 different 110-ml samples of human serum consistently by > 90% over 4 hours. X-Sorb appears to be an effective sorbent for myoglobin and warrants a trial in vivo to determine whether it is equally effective and safe.
authors.affiliation: Department of Medicine, Division of Nephrology and Hypertension, Beth Israel Medical Center, New York, New York 10003, USA.
authors.forename: Viktoriya I
authors.initials: VI
authors.lastname: Kuntsevich
authors.forename: Donald A
authors.initials: DA
authors.lastname: Feinfeld
authors.forename: Pat F
authors.initials: PF
authors.lastname: Audia
authors.forename: Wendell
authors.initials: W
authors.lastname: Young
authors.forename: Vincent
authors.initials: V
authors.lastname: Capponi
authors.forename: Marianna
authors.initials: M
authors.lastname: Markella
authors.forename: James F
authors.initials: JF
authors.lastname: Winchester
mesh_terms: D000818:Animals; D006801:Humans; D009211:Myoglobin / Q000097:blood* / Q000302:isolation & purification*; D010477:Perfusion; D010949:Plasma / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012965:Sodium Chloride / Q000378:metabolism
chemical_list: D009211:Myoglobin; D011108:Polymers; D012965:Sodium Chloride