Microwave assisted reactions of some azaheterocylic compounds.
A fast, general, environmentally friendly and facile method for preparation of five- and six-membered ring diazaheterocylic salts under microwave irradiation is presented. The N-alkylation reactions of imidazole, pyrimidine, pyridazine and phthalazine have been studied. The microwaves remarkably accelerated these N-alkylations, the reaction times decreased dramatically, the reaction conditions were milder, the consumed energy decreased considerably and the amount of solvents used was reduced substantially. Consequently, the microwave assisted alkylation of N-containing heterocycles could be considered eco-friendly. In some cases, under MW irradiation the yields are also higher. A comparative study of microwave vs. classical conditions (liquid solvents) has been done. Twelve new diazaheterocylic salts of potential practical interest were obtained.
Zbancioc
Gheorghita
G
Al. I. Cuza University of Iasi, Organic Chemistry Department, Bd. Carol 11, 700506 Iasi, Romania.
Bejan
Vasilichia
V
Risca
Marian
M
Moldoveanu
Costel
C
Mangalagiu
Ionel I
II
D020650:Combinatorial Chemistry Techniques; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D010793:Phthalazines / Q000737:chemistry; D011724:Pyridazines / Q000737:chemistry; D011743:Pyrimidines / Q000737:chemistry; D012492:Salts / Q000138:chemical synthesis / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013831:Thiamine / Q000031:analogs & derivatives
D006571:Heterocyclic Compounds; D007093:Imidazoles; D010793:Phthalazines; D011724:Pyridazines; D011743:Pyrimidines; D012492:Salts; D012997:Solvents; C008108:imidazolethiamine; D013831:Thiamine