[Place of biochemical markers of bone turnover in guidelines for diagnosis and treatment of osteoporosis].
Biochemical markers of bone turnover ara fragments of protein elements of sceleton (or product of their degradation) or enzymes and proteins release into circulation during metabolic activity cells of osteogenesis--osteoblasts and cells of osteoclastic--osteoclasts. Their concentrations at plasma and urine give us information about all metabolic processes take place presently into whole sceletal system. Measuring of concentration biochemical markers of bone turnover let us evaluate the speed of osteogenesis and osteoclastic. In this way we can predict the fractures and the changes of bone mass which will come from treatment. At polish guidelines for diagnosis and treatment of osteoporosis allowing for measuring concentration some biochemical markers of bone turnover in prediction individual 10 years risk of the fracture at postmenopausal women and in prediction the effectiveness of the treatment of osteoporosis after short time (3 months). The aim of this paper is to present the current state of knowledge on the biochemical markers of bone turnover and their place at diagnosis and treatment of osteoporosis.
Kiryłów
Ewa
E
Wojskowy Instytut Medyczny w Warszawie, CSK MON, Klinika Endokrynologii i Terapii Izotopowej. ewa.kirylow@kirbud.pl
Kamiński
Grzegorz
G
D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D010024:Osteoporosis / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D011044:Poland; D017410:Practice Guidelines as Topic
D015415:Biomarkers