The expression patterns of Nogo-A and NgR in the neonatal rat visual nervous system.
Previous studies have shown that Nogo-NgR system plays multiple roles in controlling axonal regeneration and neuronal plasticity. However, the investigation on the distributions of Nogo and NgR was limited to restricted areas or special ages, and their expression patterns in the neonatal visual nervous system is still unknown. Frozen sections were made from eyeballs and brains of three neonatal rats, and expression of Nogo and NgR proteins were examined by immunofluorescence under a laser confocal microscopy. Nogo and NgR were observed to express in the cell bodies of retina, lateral geniculate bodies and visual cortex of the neonatal rats. Our results provide evidences that the Nogo-NgR system may play an active role in the plasticity of neonatal visual system.
Xiaolei
Yin
Y
Department of Ophthalmology, Daping Hospital, Third Military Medical University, 10, Changjiang Zhilu, Daping, Chongqing, 400042, China. yinxiaolei971221@yahoo.com
Rongdi
Yuan
Y
Shuxing
Ji
J
Jian
Ye
Y
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D058851:GPI-Linked Proteins; D015870:Gene Expression; D005829:Geniculate Bodies / Q000378:metabolism*; D009185:Myelin Proteins / Q000096:biosynthesis*; D009473:Neuronal Plasticity; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; D051381:Rats; D017207:Rats, Sprague-Dawley; D011956:Receptors, Cell Surface; D018000:Receptors, Peptide / Q000096:biosynthesis*; D012160:Retina / Q000378:metabolism*; D014793:Visual Cortex / Q000378:metabolism*
D058851:GPI-Linked Proteins; D009185:Myelin Proteins; D000070798:Nogo Proteins; D000070816:Nogo Receptor 1; D011956:Receptors, Cell Surface; D018000:Receptors, Peptide; C000603197:Rtn4 protein, rat; C486581:Rtn4r protein, rat