title: New onsets of substance use disorders in borderline personality disorder over 7 years of follow-ups: findings from the Collaborative Longitudinal Personality Disorders Study.
abstract: OBJECTIVE
  The purpose of this study was to examine whether patients with borderline personality disorder (BPD) have a higher rate of new onsets of substance use disorders (SUD) than do patients with other personality disorders (OPD).
  
  
  METHODS
  This study uses data from the Collaborative Longitudinal Personality Disorder Study (CLPS), a prospective naturalistic study with reliable repeated measures over 7 years of follow-up.
  
  
  METHODS
  Multiple clinical sites in four northeastern US cities.
  
  
  METHODS
  A total of 175 patients with BPD and 396 patients with OPD (mean age 32.5 years) were assessed at baseline and at 6, 12, 24, 36, 48, 60, 72 and 84 months.
  
  
  METHODS
  The Structured Clinical Interview for DSM-IV Axis I Disorders and the Diagnostic Interview for DSM-IV Personality Disorders were used at baseline, the Follow-Along version of the DIPD-IV and the Longitudinal Interval Follow-up Evaluation at the follow-up evaluations. Kaplan-Meier analyses were calculated to generate the time to new onsets.
  
  
  RESULTS
  BPD patients showed a shorter time to new onsets of SUD. Thirteen per cent of BPD patients developed a new alcohol use disorder and 11% developed a new drug use disorder, compared to rates of 6% and 4%, respectively, for OPD. Non-remitted BPD and remitted BPD patients did not differ significantly in rates of new onsets of SUD.
  
  
  CONCLUSIONS
  BPD patients have a high vulnerability for new onsets of SUDs even when their psychopathology improves. These findings indicate some shared etiological factors between BPD and SUD and underscore the clinical significance of treating SUD when it co-occurs in BPD patients.
authors.affiliation: Harvard Medical School, McLean Hospital, Belmont, MA, USA. marc.walter@upkbs.ch
authors.forename: Marc
authors.initials: M
authors.lastname: Walter
authors.forename: John G
authors.initials: JG
authors.lastname: Gunderson
authors.forename: Mary C
authors.initials: MC
authors.lastname: Zanarini
authors.forename: Charles A
authors.initials: CA
authors.lastname: Sanislow
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Grilo
authors.forename: Thomas H
authors.initials: TH
authors.lastname: McGlashan
authors.forename: Leslie C
authors.initials: LC
authors.lastname: Morey
authors.forename: Shirley
authors.initials: S
authors.lastname: Yen
authors.forename: Robert L
authors.initials: RL
authors.lastname: Stout
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Skodol
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000150:complications*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000523:psychology*; D055815:Young Adult