title: Tramadol for prevention of postanaesthetic shivering: a randomised double-blind comparison with pethidine.
abstract: The present study was conducted with the aims of comparing intravenous tramadol 1, 2 and 3 mg.kg(-1) with pethidine 0.5 mg.kg(-1) for prophylaxis of postanaesthetic shivering and to find a dose of tramadol that could provide the dual advantage of antishivering and analgesic effect in the postoperative period. The study included 165 patients, randomly allocated to five groups of 33 each. Tramadol in doses of 1, 2 and 3 mg.kg(-1), pethidine 0.5 mg.kg(-1) or normal saline were administered at the time of wound closure. All three doses of tramadol were effective and comparable to pethidine in preventing postanaesthetic shivering. Tramadol 2 mg.kg(-1) had the best combination of antishivering and analgesic efficacy without excessive sedation and thus appeared to be a good choice to be administered at the time of wound closure to provide antishivering effect and analgesia without significant side effects in the postoperative period.
authors.affiliation: Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Dehli, India. medhamohta@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Mohta
authors.forename: N
authors.initials: N
authors.lastname: Kumari
authors.forename: A
authors.initials: A
authors.lastname: Tyagi
authors.forename: A K
authors.initials: AK
authors.lastname: Sethi
authors.forename: D
authors.initials: D
authors.lastname: Agarwal
authors.forename: M
authors.initials: M
authors.lastname: Singh
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008614:Meperidine / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D012720:Severity of Illness Index; D012768:Shivering / Q000187:drug effects*; D014147:Tramadol / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000701:Analgesics, Opioid; D014147:Tramadol; D008614:Meperidine