title: Use of single-agent carboplatin as adjuvant or neoadjuvant therapy in conjunction with amputation for appendicular osteosarcoma in dogs.
abstract: Survival following amputation and administration of single-agent carboplatin for treatment of appendicular osteosarcoma (OSA) in dogs was retrospectively examined. Records of 155 dogs with appendicular OSA treated with amputation and single-agent carboplatin were included from 14 centers. Any carboplatin dosage, number of doses, and protocol schedule were eligible for inclusion. The median disease-free interval (DFI) was 256 days. The median overall survival time was 307 days. Similar prognostic survival factors were identified in this study as reported in prior studies of canine appendicular OSA. Median DFI and survival were comparable to those reported in the original Bergman et al publication. Carboplatin treatment improves the survival probability in dogs with appendicular OSA compared to amputation alone and remains an acceptable alternative to adjuvant treatment with cisplatin.
authors.affiliation: Veterinary Specialty Hospital of San Diego, 1733 Nautilus Street, La Jolla, California 92037, USA.
authors.forename: Brenda
authors.initials: B
authors.lastname: Phillips
authors.forename: Barbara E
authors.initials: BE
authors.lastname: Powers
authors.forename: William S
authors.initials: WS
authors.lastname: Dernell
authors.forename: Rod C
authors.initials: RC
authors.lastname: Straw
authors.forename: Chand
authors.initials: C
authors.lastname: Khanna
authors.forename: Gary S
authors.initials: GS
authors.lastname: Hogge
authors.forename: David M
authors.initials: DM
authors.lastname: Vail
mesh_terms: D000671:Amputation, Surgical / Q000662:veterinary*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000601:surgery*; D016190:Carboplatin / Q000627:therapeutic use* / Q000633:toxicity; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery*; D004285:Dogs; D005260:Female; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy* / Q000601:surgery*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin