SBF transcription factor complex positively regulates UV mutagenesis in Saccharomyces cerevisiae.
The collection of gene deletion mutants of Saccharomyces cerevisiae was used to screen for novel genes required for UV-induced mutagenesis. We found the SBF transcription factor (Swi4/Swi6 protein complex) to be required for wild-type levels of UV mutability in forward and reverse mutation assays. Expression of translesion polymerase zeta component Rev7 was identified as a target of SBF-dependent regulation.
Gong
Jinjun
J
Department of Cell Biology and Genetics, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, Texas 76107, USA.
Siede
Wolfram
W
D004259:DNA-Directed DNA Polymerase / Q000235:genetics*; D017353:Gene Deletion; D015966:Gene Expression Regulation, Fungal; D016296:Mutagenesis / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000528:radiation effects; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics* / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D014466:Ultraviolet Rays
C092219:REV7 protein, S cerevisiae; C081540:SBF protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D004259:DNA-Directed DNA Polymerase