title: Directed Hydrozirconation of Homopropargylic Alcohols.
abstract: Homopropargylic alcohols undergo directed hydrozirconation with Schwartz reagent (Cp(2)ZrHCl) to generate vinyl-metal species in which the metal fragment is proximal to the alkoxide. Electrophilic trapping yields tri-substituted olefins in good yields with good control of regio- and stereochemistry. Experiments with a homopropargylic ether confirmed the role of the hydroxyl group in the directed hydrometalation.
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern MedicalCenter at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Liu
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Ready