Intrathecal methotrexate-induced acute chorea.
Intrathecal methotrexate is the mainstay of central nervous system prophylaxis in acute lymphoblastic leukemia. We describe a patient who developed acute chorea after last dose of intrathecal methotrexate therapy and recovered completely.
Necioğlu Orken
Dilek
D
Departments of Neurology, Sişli Etfal Education and Research Hospital, Istanbul, Turkey. orkenada@superonline.com
Yldrmak
Yldz
Y
Kenangil
Gülay
G
Kandraloğlu
Nursu
N
Forta
Hulki
H
Celik
Münevver
M
D000208:Acute Disease; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D002819:Chorea / Q000139:chemically induced* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D016896:Treatment Outcome
D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate