[Activity of indolicidin, alone or together with oxacillin, against Staphylococcus aureus and S. epidermidis].
Difficulties in the treatment of staphylococcal infections as well as the increasing frequency of isolating resistant clinical strains have prompted a search, among the products of immune systems of plants and animals, for more effective antistaphylococcal therapies. This study examined the activity of indolicidin towards the planktonic cultures and biofilm of Staphylococcus aureus and S. epidermidis strains representing different clinical sources and various profiles of drug sensitivity. The synergistic effect between the peptide and oxacilin was also studied.
Walencka
Elzbieta
E
Zakład Biologii Zakazeń, Katedra Immunologii i Biologii Infekcyjnej, Instytut Mikrobiologii i Immunologii, Uniwersytet Lódzki.
Sadowska
Beata
B
Wieckowska-Szakiel
Marzena
M
Rózalska
Barbara
B
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D023181:Antimicrobial Cationic Peptides / Q000008:administration & dosage*; D018441:Biofilms; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000008:administration & dosage*; D013045:Species Specificity; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects*; D013212:Staphylococcus epidermidis / Q000145:classification / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C073143:indolicidin; D010068:Oxacillin