title: Piecing together the ESCRTs.
abstract: High-resolution structural analysis has characterized nearly all of the individual domains of ESCRT (endosomal sorting complex required for transport) subunits, all of the core structures of the soluble complexes and many of the interactions involving domains. Recent emphasis in structural studies has shifted towards efforts to integrate these structures into a larger-scale model. Molecular simulations, hydrodynamic analysis, small-angle X-ray scattering and cryo-EM (electron microscopy) techniques have all been brought to bear on the ESCRT system over the last year.
authors.affiliation: Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U.S. Department of Health and Human Services, Bethesda, MD 20892, USA. hurley@helix.nih.gov
authors.forename: James H
authors.initials: JH
authors.lastname: Hurley
authors.forename: Young Jun
authors.initials: YJ
authors.lastname: Im
authors.forename: Hyung Ho
authors.initials: HH
authors.lastname: Lee
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Ren
authors.forename: Thomas
authors.initials: T
authors.lastname: Wollert
authors.forename: Dong
authors.initials: D
authors.lastname: Yang
mesh_terms: D011992:Endosomes / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000378:metabolism*; D021381:Protein Transport; D033921:Vesicular Transport Proteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D046912:Multiprotein Complexes; D033921:Vesicular Transport Proteins