Uveitis subtypes in a german interdisciplinary uveitis center--analysis of 1916 patients.
OBJECTIVE
Studies on the epidemiology of uveitis are rare and cohorts are small. We analyzed the frequencies of classified forms of uveitis in all patients at our center.


METHODS
We studied 1916 consecutive patients with inflammatory eye disease. Data were analyzed regarding associated systemic disease, infection, ocular syndromes, anatomic localization, age, and sex.


RESULTS
In 59.1% of patients, a classified form of uveitis was observed: associated systemic diseases in 43.7%, the most frequent ones sarcoidosis (17.4%) and ankylosing spondylitis (16.8%); ocular syndromes in 34.3%, the most frequent HLA-B27-positive anterior uveitis (AU; 35.1%) and Fuchs uveitis syndrome (FUS; 34.3%); and infections in 22.4%, the most frequent herpetic infections (46.1%) and toxoplasmosis (31.5%). We found AU in 45.4% of patients (15.4% HLA-B27-positive AU and 11.3% FUS), intermediate uveitis in 22.9% (unclassified 53.7% and multiple sclerosis 10.3%), and posterior uveitis in 13.5% (24.7% toxoplasmosis). Panuveitis was diagnosed in 6.2% of cases (Behçet's disease 12.6%; sarcoidosis 10.9%). The remaining 12.0% of cases showed extrauveal manifestations (scleritis, episcleritis, keratitis, optic neuritis, myositis, and orbital inflammation).


CONCLUSIONS
We describe the largest cohort to date of consecutive patients from a specialized uveitis center. The high frequency of classified disease, nearly 60% in our clinic, shows the usefulness of an interdisciplinary approach, oriented on anatomic presentation.
Jakob
Eva
E
Interdisciplinary Uveitis Center, University Eye Hospital, Department for Internal Medicine V, University of Heidelberg, INF 350, Heidelberg 69120, Germany.
Reuland
Mirjam S
MS
Mackensen
Friederike
F
Harsch
Nadine
N
Fleckenstein
Monika
M
Lorenz
Hanns-Martin
HM
Max
Regina
R
Becker
Matthias D
MD
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000554:Ambulatory Care Facilities / Q000706:statistics & numerical data; D002648:Child; D015331:Cohort Studies; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000453:epidemiology; D017678:Sex Distribution; D013167:Spondylitis, Ankylosing / Q000453:epidemiology; D014605:Uveitis / Q000145:classification* / Q000453:epidemiology*; D055815:Young Adult