title: Autoantibodies against glutamate, gamma-aminobutyric acid, and norepinephrine in mechanisms of neuropathic pain syndrome.
abstract: The production and role of autoantibodies against neurotransmitters glutamate, gamma-aminobutyric acid, and norepinephrine were studied in rats with experimental neuropathic pain syndrome induced by sciatic nerve transection. Nerve transection in rats was followed by behavioral reaction of autotomy (self-mutilation of the operated limb), which often accompanies neuropathic pain syndrome. The development of neuropathic pain syndrome was accompanied by increased production of autoantibodies against glutamate, gamma-aminobutyric acid, and norepinephrine. A negative correlation was found between the amount of autoantibodies against neurotransmitters and severity of neuropathic pain syndrome. Our results suggest that antibodies against glutamate and norepinephrine exhibit protective activity.
authors.affiliation: Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Evseev
authors.forename: L A
authors.initials: LA
authors.lastname: Vetrile
authors.forename: V S
authors.initials: VS
authors.lastname: Smirnova
authors.forename: V N
authors.initials: VN
authors.lastname: Grafova
authors.forename: I A
authors.initials: IA
authors.lastname: Zaharova
authors.forename: N A
authors.initials: NA
authors.lastname: Trekova
authors.forename: M L
authors.initials: ML
authors.lastname: Kukushkin
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D020918:Complex Regional Pain Syndromes / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control; D018698:Glutamic Acid / Q000276:immunology; D008297:Male; D018377:Neurotransmitter Agents / Q000276:immunology*; D009619:Nociceptors / Q000276:immunology / Q000502:physiology; D009638:Norepinephrine / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries; D005680:gamma-Aminobutyric Acid / Q000276:immunology
chemical_list: D001323:Autoantibodies; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine