Molecular pathways involved in hair follicle tumor formation: all about mammalian target of rapamycin?
Hair follicle tumors show a broad range of phenotypic variability and diverse histopathological characteristics. To date, different genes and signalling cascades have been implicated in the development and growth of these tumors including the sonic hedgehog, nuclear factor kappa-B and wingless pathway. While the former three have received ample attention, little is known about the possible role of mammalian target of rapamycin (mTOR) in trichofollicular tumorigenesis. Here, we delineate how mTOR can link the various signalling pathways, thereby proposing a unifying model for hair follicle tumor formation.
van Steensel
Maurice A M
MA
Department of Dermatology, University Medical Centre Maastricht, University Hospital Maastricht, Maastricht, The Netherlands. mvst@sder.azm.nl
van Geel
Michel
M
Badeloe
Sadhanna
S
Poblete-Gutiérrez
Pamela
P
Frank
Jorge
J
D018859:Hair Follicle; D053823:Hedgehog Proteins / Q000502:physiology; D006801:Humans; D016328:NF-kappa B / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D012878:Skin Neoplasms / Q000503:physiopathology*; D058570:TOR Serine-Threonine Kinases; D051153:Wnt Proteins / Q000502:physiology
D053823:Hedgehog Proteins; D016328:NF-kappa B; D051153:Wnt Proteins; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases