title: [Growth inhibition of prostate cancer cells by epigallocatechin-3-gallate in the presence of Zn2+ in vitro].
abstract: In this paper, the cytotoxicity of EGCG against PC-3 prostate cancer cells and its molecular mechanism in the presence and absence of Zn2+ in vitro were investigated. The results showed that both EGCG and Zn2+ suppressed clonegenecity of PC-3 cells, and the suppression effect was enhanced in the coexist system of EGCG and Zn2+. MMP-9 is thought to play a significant role in cancer cell migration and invasion. In the present paper, the results showed that EGCG suppressed the activity of MMP-9 in PC-3 cells in the presence of Zn2+, as a result, migration ability of the cells was significantly decreased.
authors.affiliation: Department of Tea Sciences, Zhejiang University, Hangzhou.
authors.forename: Lan Cui
authors.initials: LC
authors.lastname: Zhang
authors.forename: Sheng Rong
authors.initials: SR
authors.lastname: Shen
authors.forename: Shi Li
authors.initials: SL
authors.lastname: Sun
authors.forename: Jun Guo
authors.initials: JG
authors.lastname: Yang
authors.forename: Guo Qing
authors.initials: GQ
authors.lastname: He
authors.forename: Hai Ning
authors.initials: HN
authors.lastname: Yu
mesh_terms: D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015032:Zinc / Q000494:pharmacology*
chemical_list: D002392:Catechin; C045651:epigallocatechin gallate; D020780:Matrix Metalloproteinase 9; D015032:Zinc