title: Solid-phase synthesis of 1,3,6-trisubstituted-1H-thiazolo[4,5-c][1,2]thiazin-4(3H)one-2,2-dioxide derivatives using traceless linker.
abstract: A new solid-phase route for preparation of 1,3,6-trisubstituted-1H-thiazolo[4,5-c][1,2]thiazin-4(3H)one-2,2-dioxide derivatives is described. Our synthetic route is begun with a thiazole resin and relies on the sulfonamide formation, Mitsunobu-type N-alkylation, cyclization, and nucleophilic substitution methodology cleavage on a solid support. The strategy permits the incorporation of three points of diversity into the thiazolo[4,5-c][1,2]thiazine ring system in good overall yields.
authors.affiliation: Center for Drug Discovery Technologies, Korea Research Institute of Chemical Technology, PO Box 107, Singseongno, Yuseong-gu, Daejeon 305-600, Korea.
authors.forename: Taeho
authors.initials: T
authors.lastname: Lee
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Park
authors.forename: Moon-Kook
authors.initials: MK
authors.lastname: Jeon
authors.forename: Young-Dae
authors.initials: YD
authors.lastname: Gong
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D013843:Thiazines / Q000138:chemical synthesis* / Q000737:chemistry; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D013843:Thiazines; D013844:Thiazoles