title: Polymorphism of the TGFB1 gene is not associated with bronchial allergic asthma in a Polish population.
abstract: Allergic asthma is a complex genetic disorder that involves interactions between genetic and environmental factors. Some studies have indicated that transforming growth factor beta(1) (TGF-beta(1)), a pleiotropic cytokine regulating inflammatory reactions and airway remodeling, may participate in the pathogenesis of asthma. Several polymorphisms have been described in the TGFB1 gene; some were tested in allergic asthma, with conflicting results. The aim of this study was to investigate the possible associations of four TGFB1 gene polymorphisms (-800G>A, -509C>T, 869T>C, and 915G>C) with allergic asthma in a Polish population. These four single nucleotide polymorphisms were genotyped in 247 asthmatic patients (including 207 atopic individuals) and 287 unrelated healthy volunteers by means of the polymerase chain reaction-restriction fragment length polymorphism method. No significant differences between patients and controls in allele, genotype, and haplotype frequencies were reported. Logistic regression analysis of genotype distribution and allele positivity adjusted for age and sex did not reveal any significant differences between all patients or patients selected for atopy and controls. Thus, no evidence was reported for a contribution of the TGFB1 gene to allergic asthma in a Polish population. The results are discussed in the context of similar studies in other populations.
authors.affiliation: Laboratory of Immunogenetics, Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland. andrzej@iitd.pan.wroc.pl
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wiśniewski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Obojski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Pawlik
authors.forename: Monika
authors.initials: M
authors.lastname: Jasek
authors.forename: Wioleta
authors.initials: W
authors.lastname: Luszczek
authors.forename: Edyta
authors.initials: E
authors.lastname: Majorczyk
authors.forename: Izabela
authors.initials: I
authors.lastname: Nowak
authors.forename: Piotr
authors.initials: P
authors.lastname: Kuśnierczyk
mesh_terms: D000328:Adult; D001249:Asthma / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011044:Poland; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D055815:Young Adult
chemical_list: D053773:Transforming Growth Factor beta1