Mice are not susceptible to hepatitis E virus infection.
To determine whether or not mice are susceptible to hepatitis E virus (HEV) infection, C57BL/6 mice were experimentally infected with genotypes 1, 3 and 4 HEV by intravenous injection. Serum and stool samples were collected and used to detect HEV RNA and anti-HEV antibodies by RT-PCR and ELISA. The virus infection was monitored up to two months after inoculation; however, none of the serum or stool samples was positive for virus replication, demonstrating that C57BL/6 mice were not susceptible to HEV.
Li
Tian-Cheng
TC
Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. litc@nih.go.jp
Suzaki
Yuriko
Y
Ami
Yasushi
Y
Tsunemitsu
Hiroshi
H
Miyamura
Tatsuo
T
Takeda
Naokazu
N
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004198:Disease Susceptibility / Q000821:virology*; D016751:Hepatitis E; D016752:Hepatitis E virus / Q000276:immunology*; D008252:Macaca fascicularis / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL
D000914:Antibodies, Viral