Metabolism of cisplatin to a nephrotoxin.
Hanigan
Marie H
MH
Townsend
Danyelle M
DM
Cooper
Arthur J L
AJ
D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000633:toxicity*; D001711:Biotransformation; D013437:Carbon-Sulfur Lyases / Q000037:antagonists & inhibitors / Q000378:metabolism; D002478:Cells, Cultured; D002945:Cisplatin / Q000493:pharmacokinetics* / Q000633:toxicity*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology; D007674:Kidney Diseases / Q000139:chemically induced*; D008190:Lyases / Q000378:metabolism; D051379:Mice; D051381:Rats; D000637:Transaminases / Q000378:metabolism; D005723:gamma-Glutamyltransferase / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007555:Isoxazoles; D005723:gamma-Glutamyltransferase; D000637:Transaminases; C427605:glutamine - phenylpyruvate transaminase; D008190:Lyases; D013437:Carbon-Sulfur Lyases; C108902:cysteine-S-conjugate beta-lyase; C006303:acivicin; D002945:Cisplatin