title: Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging.
abstract: This paper presents an evaluation of a prototype diffuse optical tomography (DOT) system. Seventeen women with 18 breast lesions (10 invasive carcinomas, 2 fibroadenomas, and 6 benign cysts; diameters 13-54 mm) were evaluated with DOT and magnetic resonance imaging (MRI). A substantial fraction of the original 36 recruited patients could not be examined using this prototype due to technical problems. A region of interest (ROI) was drawn at the lesion position as derived from MRI and at the mirror image site in the contralateral healthy breast. ROIs were assessed quantitatively and qualitatively by two observers independently in two separate readings. Intra- and interobserver agreements were calculated using kappa statistics (k) and intraclass correlation coefficients (ICCs). Discriminatory values for presence of malignancy were determined by receiver operating characteristic (ROC) analyses. Intraobserver agreements were excellent (k 0.88 and 0.88; ICC 0.978 and 0.987), interobserver agreements were good to excellent (k 0.77-0.95; ICC 0.96-0.98). Discriminatory values for presence of malignancy were 0.92-0.93 and 0.97-0.99 for quantitative and qualitative ROC analysis, respectively. This DOT system has the potential to discriminate malignant from benign breast tissue in a reproducible qualitative and quantitative manner. Important technical improvements are required before this technique is ready for clinical application.
authors.affiliation: Department of Radiology, University Medical Center Utrecht, E.01.132, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands. s.m.w.y.vandeven-2@umcutrecht.nl
authors.forename: Stephanie M W Y
authors.initials: SM
authors.lastname: van de Ven
authors.forename: Sjoerd G
authors.initials: SG
authors.lastname: Elias
authors.forename: Andrea J
authors.initials: AJ
authors.lastname: Wiethoff
authors.forename: Marjolein
authors.initials: M
authors.lastname: van der Voort
authors.forename: Tim
authors.initials: T
authors.lastname: Nielsen
authors.forename: Bernhard
authors.initials: B
authors.lastname: Brendel
authors.forename: Claas
authors.initials: C
authors.lastname: Bontus
authors.forename: Falk
authors.initials: F
authors.lastname: Uhlemann
authors.forename: Rami
authors.initials: R
authors.lastname: Nachabe
authors.forename: Rik
authors.initials: R
authors.lastname: Harbers
authors.forename: Michiel
authors.initials: M
authors.lastname: van Beek
authors.forename: Leon
authors.initials: L
authors.lastname: Bakker
authors.forename: Martin B
authors.initials: MB
authors.lastname: van der Mark
authors.forename: Peter
authors.initials: P
authors.lastname: Luijten
authors.forename: Willem P Th M
authors.initials: WP
authors.lastname: Mali
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D015588:Observer Variation; D010363:Pattern Recognition, Automated; D011446:Prospective Studies; D012372:ROC Curve; D041622:Tomography, Optical / Q000379:methods*