title: Blood flow in the peripapillary retina in exfoliation glaucoma.
abstract: OBJECTIVE
  The aim of this article is to study peripapillary retinal blood flow in patients with progressive and stable exfoliation glaucoma (ExG).
  
  
  METHODS
  Fifty-eight eyes with ExG were included; 25 of them had progressive and 33 stable glaucoma. Retinal blood flow in the peripapillary retina was measured with scanning laser Doppler flowmetry. Acquired flow maps were analysed with the automatic full-field perfusion image analyser. Multiple logistic regression was used to model progression of glaucoma.
  
  
  RESULTS
  Mean retinal flow (MF; correlation coefficient, P-value; R = 0.36, P = 0.006) and retinal minimum diastolic flow (R = 0.33, P = 0.011) were positively correlated with visual field mean defect (MD). Factors associated with progressive glaucoma were mean intraocular pressure (OR = 1.198 for each mmHg; P = 0.050) and visual field MD (OR = 1.134 for each dB; P = 0.013). Age (P = 0.35), MF (P = 0.58), or presence of cardiovascular disease (P = 0.17) were not associated with glaucoma progression.
  
  
  CONCLUSIONS
  No difference in peripapillary retinal blood flow between progressive and stable ExG could be found.
authors.affiliation: Helsinki University Eye Hospital, Helsinki, Finland. mika.harju@aad.fi
authors.forename: Mika
authors.initials: M
authors.lastname: Harju
authors.forename: Leena
authors.initials: L
authors.lastname: Kurvinen
authors.forename: Jukka
authors.initials: J
authors.lastname: Saari
authors.forename: Eija
authors.initials: E
authors.lastname: Vesti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D003430:Cross-Sectional Studies; D017889:Exfoliation Syndrome / Q000150:complications / Q000503:physiopathology*; D005901:Glaucoma / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D017078:Laser-Doppler Flowmetry; D008875:Middle Aged; D009898:Optic Disk / Q000503:physiopathology; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000503:physiopathology*; D014794:Visual Fields
chemical_list: D002317:Cardiovascular Agents