Turning genetic discoveries into new treatments: the Wnt/LRP-5 system as a source of new drug targets for skeletal diseases.
Bodine
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PV
Women's Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA. bodinep@wyeth.com
D000818:Animals; D016503:Drug Delivery Systems / Q000639:trends*; D006801:Humans; D026502:LDL-Receptor Related Proteins / Q000235:genetics* / Q000378:metabolism; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D009140:Musculoskeletal Diseases / Q000188:drug therapy* / Q000235:genetics* / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects / Q000235:genetics; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D051153:Wnt Proteins / Q000235:genetics* / Q000378:metabolism
D026502:LDL-Receptor Related Proteins; C555482:LRP5 protein, human; D060492:Low Density Lipoprotein Receptor-Related Protein-5; D004364:Pharmaceutical Preparations; D051153:Wnt Proteins