Determination of the subset of Sjogren's syndrome with articular manifestations by anticyclic citrullinated peptide antibodies.
OBJECTIVE
To investigate whether anticyclic citrullinated peptide antibodies (anti-CCP) predict the subset of Japanese patients with Sjögren's syndrome (SS) with articular manifestations.


METHODS
Eighty-seven patients with SS were enrolled. Prevalence of anti-CCP antibodies, IgM rheumatoid factor, anti-Ro/SSA antibody, anti-La/SSB antibody, and serum IgG concentration and their relation to articular manifestations were examined. Articular manifestations included morning stiffness and the presence of tender or swollen joints.


RESULTS
Eighty-seven SS patients were divided into 3 groups: 14 secondary SS with nonerosive rheumatoid arthritis (RA); 47 primary SS with articular manifestations; and 26 primary SS without articular manifestations. Ten out of 14 secondary SS with nonerosive RA expressed anti-CCP. Anti-CCP was the only statistically proven marker preferentially distributed in patients with articular manifestations (the first 2 groups) compared to primary SS without such manifestations; however, its frequency was low in primary SS. No patient with primary SS without articular manifestations expressed anti-CCP.


CONCLUSIONS
Anti-CCP is found in the subset of Japanese with SS with articular manifestations although most of those with anti-CCP-positive SS were classified as secondary SS with RA.
Iwamoto
Naoki
N
Unit of Translational Medicine, Department of Immunology and Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
Kawakami
Atsushi
A
Tamai
Mami
M
Fujikawa
Keita
K
Arima
Kazuhiko
K
Aramaki
Toshiyuki
T
Kawashiri
Shinya
S
Ichinose
Kunihiro
K
Kamachi
Makoto
M
Nakamura
Hideki
H
Origuchi
Tomoki
T
Ida
Hiroaki
H
Eguchi
Katsumi
K
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000453:epidemiology / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D011237:Predictive Value of Tests; D012217:Rheumatoid Factor / Q000097:blood; D016036:Seroepidemiologic Studies; D012859:Sjogren's Syndrome / Q000145:classification / Q000453:epidemiology* / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007075:Immunoglobulin M; D010456:Peptides, Cyclic; C035356:SS-A antibodies; C035357:SS-B antibodies; C487763:cyclic citrullinated peptide; D012217:Rheumatoid Factor