[Antimicrobial spectrum of antibiotic batumin].
Antibacterial activity of antibiotic batumin, isolated from Pseudomonas genus has been studied using CLSI standard methods. Batumin was highly active against all studied strains belonging to 10 species of Staphylococcus genus (minimal inhibitory concentration (MIC)--0.25-0.5 microg/ml); it has shown a moderate activity against enterobacteria of genera Salmonella, Bordetella, Escherichia, Klebsiella (MIC 8-64 microg/ml) and practically did not inhibit strains ofmicrococci, streptococci, sporeforming bacteria including Clostridium sporogenes (MIC 256 microg/ml or above). Strains of yeasts and microscopic fungi Candida tropicalis, C. utilis, C. albicans, Saccharomyces cerevisiae u Aspergillus niger were resistant to batumin. Antibiotic activity depended on test-culture cells concentration and medium pH and was greatest at pH 5.5 characteristic of human skin.
Klochko
V V
VV
Kiprianova
E A
EA
Churkina
L N
LN
Avdeeva
L V
LV
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D009930:Organic Chemicals / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D009930:Organic Chemicals; C088306:batumin