The contribution of cis-regulatory elements to head-to-head gene pairs' co-expression pattern.
Transcription regulation is one of the most critical pipelines in biological process, in which cis-elements play the role as gene expression regulators. We attempt to deduce the principles underlying the co-expression of "head-to-head" gene pairs by analyzing activities or behaviors of the shared cis-elements. A network component analysis was performed to estimate the impact of cis-elements on gene promoters and their activities under different conditions. Our discoveries reveal how biological system uses those regulatory elements to control the expression pattern of "head-to-head" gene pairs and the whole transcription regulation system.
Hao
Pei
P
School of Life Sciences, Fudan University, Shanghai, 200433, China.
Yu
Yao
Y
Zhang
XiaoYan
X
Tu
Kang
K
Fan
HaiWei
H
Zhong
Yang
Y
D005786:Gene Expression Regulation / Q000235:genetics*; D050436:Regulatory Elements, Transcriptional / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics