Acute complete splenic infarction in a patient with Hirschsprung's disease and literature review of complete splenic infarction.
Here we report a case of Hirschsprung's disease presenting with acute complete splenic infarction due to thrombus in the splenic vena. MTHFR C677T (methylenetetrahydrofolate) gene homozygote mutation was a risk factor for thrombosis. According to our knowledge, this is the first report for a Hirschsprung's disease patient with acute complete splenic infarct due to isolated splenic vein thrombosis accompanied by MTHFR C677T gene homozygote mutation.
Guler
N
N
Department of Hematology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. nilvecay@yahoo.com
Yapici
O
O
Erdem
D
D
Ogur
G
G
Ozatli
D
D
Bakir
T
T
D000328:Adult; D005260:Female; D006627:Hirschsprung Disease / Q000150:complications*; D006720:Homozygote; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D017354:Point Mutation; D013159:Splenic Infarction / Q000209:etiology*; D013162:Splenic Vein; D013927:Thrombosis
D042965:Methylenetetrahydrofolate Reductase (NADPH2)