A lysine walk to high relaxivity collagen-targeted MRI contrast agents.
A strategy for preparing peptide-based magnetic resonance contrast agents with multiple gadolinium chelates is described.
Caravan
Peter
P
A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129, USA. caravan@nmr.mgh.harvard.edu
Das
Biplab
B
Deng
Qing
Q
Dumas
Stéphane
S
Jacques
Vincent
V
Koerner
Steffi K
SK
Kolodziej
Andrew
A
Looby
Richard J
RJ
Sun
Wei-Chuan
WC
Zhang
Zhaoda
Z
D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D003094:Collagen / Q000378:metabolism*; D003287:Contrast Media / Q000138:chemical synthesis*; D019786:Gadolinium DTPA / Q000737:chemistry; D008239:Lysine / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
D003287:Contrast Media; D003094:Collagen; D019786:Gadolinium DTPA; D008239:Lysine