Regulation of self-renewal and differentiation in the Drosophila nervous system.
Stem cells can divide symmetrically to generate two similar daughter cells and expand the stem cell pool or asymmetrically to self-renew and generate differentiating daughter cells. The proper balance between symmetric and asymmetric division is critical for the generation and subsequent repair of tissues. Furthermore, unregulated stem cell division has been shown to result in tumorous overgrowth. The Drosophila nervous system has proved to be a fruitful model system for studying the biology of neural stem cell division and uncovering the molecular mechanisms that, when disrupted, can lead to tumor formation. We are using the Drosophila embryonic and larval nervous systems as models to study the regulation of symmetric and asymmetric stem cell division.
Southall
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TD
The Gurdon Institute and Department of Physiology, Development, and Neuroscience, University of Cambridge, Cambridge CB2 1QN, United Kingdom.
Egger
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B
Gold
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KS
Brand
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AH
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D004330:Drosophila / Q000166:cytology* / Q000235:genetics / Q000254:growth & development; D029721:Drosophila Proteins / Q000235:genetics; D017344:Genes, Insect; D008959:Models, Neurological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D009420:Nervous System / Q000166:cytology* / Q000254:growth & development; D009687:Nuclear Proteins / Q000235:genetics; D013234:Stem Cells / Q000166:cytology*; D014157:Transcription Factors / Q000235:genetics
D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C073099:pros protein, Drosophila