Production of protective gamma interferon by natural killer cells during early mouse hepatitis virus infection.
Gamma interferon (IFN-gamma) plays a major role in the protection against lethal infection with mouse hepatitis virus A59. IFN-gamma production reaches a maximum level 2 days after viral inoculation, especially in liver immune cells. Among these cells, natural killer cells are the major producers of this cytokine. Transfer experiments indicated that the protective role of IFN-gamma is mediated through a direct effect on cells targeted by the virus rather than through indirect activation of T lymphocytes.
Thirion
Gaëtan
G
Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B-1200 Bruxelles, Belgium.
Coutelier
Jean-Paul
JP
Unit of Experimental Medicine, Christian de Duve Institute of Cellular Pathology, Université Catholique de Louvain, B-1200 Bruxelles, Belgium.
D000818:Animals; D018352:Coronavirus Infections / Q000276:immunology*; D007371:Interferon-gamma / Q000096:biosynthesis / Q000097:blood / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008099:Liver / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D006517:Murine hepatitis virus / Q000472:pathogenicity*; D017471:Receptors, Interferon / Q000172:deficiency; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D000096743:Interferon gamma Receptor
D007371:Interferon-gamma; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor