Targeted delivery of nucleic-acid-based therapeutics to the pulmonary circulation.
Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary endothelium may become a novel therapy for the treatment of various types of lung diseases. It may also provide a new research tool to study the functions and regulation of novel genes in pulmonary endothelium. Its success is largely dependent on the development of a vehicle that is capable of efficient pulmonary delivery with minimal toxicity. This review summarizes the recent progress that has been made in our laboratory along these research directions. Factors that affect pulmonary nucleic acids delivery are also discussed.
Kuruba
Ramalinga
R
Center for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Wilson
Annette
A
Gao
Xiang
X
Li
Song
S
D000280:Administration, Inhalation; D000818:Animals; D000954:Antigens, Surface / Q000187:drug effects; D002412:Cations / Q000493:pharmacokinetics; D000229:Dependovirus / Q000235:genetics; D004337:Drug Carriers / Q000008:administration & dosage / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D042783:Endothelial Cells / Q000187:drug effects; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D007275:Injections, Intravenous; D008055:Lipids / Q000008:administration & dosage / Q000493:pharmacokinetics; D008081:Liposomes / Q000008:administration & dosage / Q000493:pharmacokinetics; D008168:Lung / Q000098:blood supply* / Q000166:cytology; D051379:Mice; D009696:Nucleic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D009841:Oligonucleotides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D010455:Peptides / Q000008:administration & dosage / Q000493:pharmacokinetics; D011108:Polymers / Q000493:pharmacokinetics; D011652:Pulmonary Circulation; D034741:RNA, Small Interfering / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use
D000954:Antigens, Surface; D002412:Cations; D004337:Drug Carriers; D008055:Lipids; D008081:Liposomes; D009696:Nucleic Acids; D009841:Oligonucleotides; D010455:Peptides; D011108:Polymers; D034741:RNA, Small Interfering