title: Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports.
abstract: BACKGROUND
  Chondrosarcomas and chordomas are usually chemoresistant bone tumors and may have a poor prognosis when advanced. They are usually associated with worsening pain difficult to control.
  
  
  METHODS
  Zoledronic acid was used in a 63-year-old man with metastatic chondrosarcoma and in a 66-year-old woman with a diagnosis of sacrum chordoma both reporting severe pain related to tumor.
  
  
  RESULTS
  In the first case, zoledronic acid was able to maintain pain control despite disease progression following chemotherapy, in the other case, zoledronic acid only produced significant clinical benefit.
  
  
  CONCLUSIONS
  Control of pain associated with bone tumors such as chondrosarcoma and chondroma may significantly improve from use of zoledronic acid, independently from tumor response to other treatments. Evaluation on larger series are needed to confirm the clinical effect of this bisphosphonate on such tumors.
authors.affiliation: Medical Oncology Unit San Giovanni di Dio Hospital, 80020 Frattaminore, Naples, Italy. lilianamontella@libero.it
authors.forename: Liliana
authors.initials: L
authors.lastname: Montella
authors.forename: Raffaele
authors.initials: R
authors.lastname: Addeo
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Faiola
authors.forename: Gregorio
authors.initials: G
authors.lastname: Cennamo
authors.forename: Rosario
authors.initials: R
authors.lastname: Guarrasi
authors.forename: Elena
authors.initials: E
authors.lastname: Capasso
authors.forename: Rosanna
authors.initials: R
authors.lastname: Mamone
authors.forename: Michele
authors.initials: M
authors.lastname: Caraglia
authors.forename: Salvatore
authors.initials: S
authors.lastname: Del Prete
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002812:Chondroma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D002813:Chondrosarcoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000556:secondary*; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012447:Sacrum / Q000000981:diagnostic imaging / Q000473:pathology*; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed; D000077211:Zoledronic Acid
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid