Transplantation of xenogenic cardiomyocytes in experimental epinephrine-induced damage to myocardium: enzyme activity and morphological parameters.
We studied the effect of xenogenic neonatal cardiomyocytes on enzymatic processes in rat myocardium under conditions of epinephrine-induced damage. It was found that transplantation of the cell preparation restricts the zone of suppressed enzyme activity in the myocardium and promotes its recovery. Less pronounced metabolic disturbances corresponded to less pronounced morphological changes in the myocardium.
Bogorodskaya
S L
SL
Research Center of Reconstructive and Repair Surgery, East Siberian Research Center, Siberian Division of Russian Academy of Medical Sciences, Irkutsk. bogorodskaya@mail.ru
Clinova
S N
SN
Mikashova
M B
MB
Golubev
S S
SS
Pivovarov
J I
JI
Kurilskaya
T E
TE
Runovich
A A
AA
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000322:Adrenergic Agonists / Q000494:pharmacology; D000818:Animals; D003402:Creatine Kinase / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000201:enzymology / Q000473:pathology*; D032383:Myocytes, Cardiac / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000637:transplantation*; D051381:Rats; D014183:Transplantation, Heterologous
D000322:Adrenergic Agonists; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D000251:Adenosine Triphosphatases; D004837:Epinephrine