[Roles of serum and urinary interleukins 13Ralpha2 and other cytokines in pediatric Henoch-Schonlein purpura].
OBJECTIVE
To study the roles of serum and urinary interleukins (IL)-13Ralpha2, IL-4, IL-6, IL-8 and tumor necrosis factor-alpha(TNF-alpha) in pediatric Henoch-Schonlein purpura (HSP).


METHODS
Serum and urinary levels of IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha were examined using ELISA in 52 children with HSP and 45 healthy children. The results were compared between the two groups.


RESULTS
Serum levels of IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha in HSP patients with or without renal lesions were higher than those in the control group (p<0.01 or 0.05). Urinary levels of IL-6 and TNF-alpha in HSP patients without renal lesions were higher than those in the control group (p<0.05). Except for urinary levels of IL-6 and TNF-alpha, urinary IL-13Ralpha2 levels in HSP patients with renal lesions (HSPN) were higher than those in the control group (p<0.05).


CONCLUSIONS
Cytokines IL-13Ralpha2, IL-4, IL-6, IL-8 and TNF-alpha may play roles in the pathogenesis of pediatric HSP/HSPN.
Yu
Yan-Hong
YH
Department of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Pan
Kai-Li
KL
Li
Qi
Q
Zhang
Bao-Juan
BJ
Huang
Ying
Y
Zhang
Jing-Jing
JJ
DU
Li
L
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000502:physiology*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000209:etiology* / Q000276:immunology; D053663:Interleukin-13 Receptor alpha2 Subunit / Q000097:blood / Q000502:physiology*; D015850:Interleukin-6 / Q000502:physiology; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D053663:Interleukin-13 Receptor alpha2 Subunit; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha