title: Traumatic brain injury in children: recent advances in management.
abstract: To define and discuss new developments in the field of pediatric traumatic brain injury (TBI). Review of several recent key studies on therapy since publication of the first U.S. traumatic brain injury guidelines in 2003. In addition, we discuss new developments in the use of biomarkers of brain injury in TBI diagnosis and also discuss recent advances in bedside neuromonitoring that may be helpful in the setting of pediatric brain injury. Important new information on optimal cerebral perfusion pressure management, cerebrospinal fluid drainage, decompressive craniectomy, hypothermia, biomarkers of brain injury along with advances in neuromonitoring are presented. The 2003 guidelines have stimulated important new research. This is reshaping bedside care.
authors.affiliation: Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, PA 15260, USA.
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Bell
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Kochanek
mesh_terms: D015415:Biomarkers / Q000097:blood; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D017408:Guidelines as Topic; D006801:Humans; D004676:Myelin Basic Protein / Q000097:blood*; D010372:Pediatrics / Q000639:trends; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D019095:Point-of-Care Systems; D009418:S100 Proteins / Q000097:blood*; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D015415:Biomarkers; D004676:Myelin Basic Protein; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase