Induced mild hypothermia in post-cardiopulmonary bypass vasoplegia syndrome.
The state of vasoplegia in immediate post-cardiopulmonary bypass period is characterized by severe hypotension, supranormal cardiac output, low systemic vascular resistance (SVR), and resistance to vasoconstrictors. We could successfully use induced mild hypothermia to increase SVR, and could avoid very high doses of nor-epinephrine (>0.3 mcg/kg/min) in the background of severe pulmonary hypertension (systolic pulmonary pressure> 90 mmHg). Its effects such as decreased oxygen demand, positive inotropy and better right ventricle performance probably helped to improve oxygenation in presence of pulmonary oedema.
Tripathi
Mukesh
M
Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. mukesh_tripathi@yahoo.com
Singh
Prabhat Kumar
PK
Kumar
Naresh
N
Pant
Kailash Chandra
KC
D000328:Adult; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D006333:Heart Failure / Q000150:complications; D006801:Humans; D007022:Hypotension / Q000209:etiology; D007036:Hypothermia, Induced; D008297:Male; D008946:Mitral Valve Stenosis / Q000150:complications / Q000601:surgery*; D011654:Pulmonary Edema / Q000209:etiology / Q000628:therapy; D012214:Rheumatic Heart Disease / Q000150:complications; D013577:Syndrome; D016896:Treatment Outcome; D014655:Vascular Resistance; D014664:Vasodilation