Chemotherapy-induced modifications to gastrointestinal microflora: evidence and implications of change.
Mucositis is a common side effect of chemotherapy which remains poorly understood. Despite advances in the understanding of oral and small intestinal mucositis over recent years, large intestinal mucositis, including diarrhoea, has not been well defined and the underlying mechanisms of the condition are yet to be established. The majority of the literature available concerning large intestinal mucositis is based on clinical observations, with very little basic research existing. However, from the little research conducted, it is likely that the intestinal microflora play a role in the development of chemotherapy-induced mucositis. This review will explore the potentially important relationship between intestinal microflora and the subsequent development of chemotherapy-induced mucositis.
Stringer
Andrea M
AM
Department of Medical Oncology, Royal Adelaide Hospital, and Discipline of Medicine, University of Adelaide, Eastwood, South Australia, Australia. andrea.stringer@imvs.sa.gov.au
Gibson
Rachel J
RJ
Bowen
Joanne M
JM
Keefe
Dorothy M K
DM
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D003967:Diarrhea / Q000139:chemically induced / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000187:drug effects* / Q000382:microbiology; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects / Q000382:microbiology; D007420:Intestine, Large / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D052016:Mucositis / Q000139:chemically induced* / Q000382:microbiology
D000970:Antineoplastic Agents