Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia.
Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 microg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 microg/kg simvastatin, p<0.05).
Ragino
Yu I
YI
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
Vavilin
V A
VA
Salakhutdinov
N F
NF
Makarova
S I
SI
Stakhneva
E M
EM
Safronova
O G
OG
Lyakhovich
V V
VV
Nikitin
Yu P
YP
Tolstikov
G A
GA
D000704:Analysis of Variance; D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004032:Diet; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects*; D005470:Fluorometry; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D009609:Nitrous Oxide / Q000378:metabolism; D011817:Rabbits; D019821:Simvastatin / Q000627:therapeutic use*; D014841:von Willebrand Factor / Q000378:metabolism
D000924:Anticholesteremic Agents; D000975:Antioxidants; D019332:Endothelin-1; C531004:simvaglyzin; D014841:von Willebrand Factor; D019695:Glycyrrhizic Acid; D002784:Cholesterol; D019821:Simvastatin; D043303:Aryldialkylphosphatase; D009609:Nitrous Oxide