Haploidentical hematopoietic stem cell transplantation without in vitro T cell depletion for treatment of hematologic malignancies in children.
OBJECTIVE
To evaluate the efficacy and safety of haploidentical (from family member donors) hematopoietic stem cell transplantation (HSCT) for children.


METHODS
Fifty-eight children under fourteen years old with hematological malignancies underwent haploidentical HSCT. Outcomes were analyzed.


RESULTS
Of Fifty-eight patient/donor pairs, seven (12.1%) were mismatched in two HLA loci, twenty (34.5%) in three loci, and thirty-one (53.4%) in four loci. Follow-ups were performed for a median of 915 (227-1898) days after transplantation. All patients achieved stable engraftments. The cumulative incidence of acute graft-versus-host disease (GVHD) of grade 2-4 was 54.8%7.6%, and that of grade 3-4 was 11.4%4.8%. The cumulative incidence of chronic GVHD was 45.6%7.8% for total and 19.6%6.5% for extensive. Fourty patients survived with a 3-year probability of leukemia-free survival (LFS) 44.7%13.9%. Eighteen patients died, five from infection, eight from relapse of leukemia, two from heart failure, two from GVHD, and one from lymphoproliferative disorders.


CONCLUSIONS
The results encourage extending haploidentical HSCT without T-cell depletion treatments to children with an indication for transplantation.
Huang
Xiaojun
X
Peking University Institute of Hematology, People's Hospital, 11 South Street of Xizhimen, Xicheng District, Beijing, 100044, People's Republic of China.
Liu
Daihong
D
Liu
Kaiyan
K
Xu
Lanping
L
Chen
Huan
H
Han
Wei
W
Chen
Yuhong
Y
Wang
Yu
Y
Zhang
Xiaohui
X
D000293:Adolescent; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D006086:Graft vs Host Disease; D006239:Haplotypes; D019337:Hematologic Neoplasms / Q000150:complications / Q000401:mortality / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006648:Histocompatibility; D006801:Humans; D016019:Survival Analysis; D016896:Treatment Outcome