title: Possible congenital infection with La Crosse encephalitis virus--West Virginia, 2006-2007.
abstract: La Crosse encephalitis virus (LACV) is a mosquitoborne bunyavirus of the California encephalitis serogroup. During 2003--2007, West Virginia had the greatest number of cases (95) and highest incidence of LACV disease (5.1 cases per 100,000 population) of any state.* The majority of persons infected with LACV either have no symptoms or a mild febrile illness; a limited number experience encephalitis. Although only 1%--4% of those infected with LACV develop any symptoms, children aged <16 years are at highest risk for severe neurologic disease and possible long-term sequelae. The effects of LACV infection during pregnancy and the potential for intrauterine transmission and adverse birth or developmental outcomes are unknown. This report describes the first known case of LACV infection in a pregnant woman, with evidence of possible congenital infection with LACV in her infant, based on the presence of immunoglobulin M (IgM) antibodies in umbilical cord serum at delivery. The infant was born healthy with normal neurologic and cognitive functions and no LACV symptoms. Further investigation is needed to confirm the potential for intrauterine LACV transmission and to identify immediate and long-term health risks posed to infants. Because of the potential for congenital infection, pregnant women in areas where LACV is endemic should be advised to avoid mosquitoes; health-care providers should monitor for LACV infection and sequelae among infants born to women infected with LACV during pregnancy.
mesh_terms: D000328:Adult; D004670:Encephalitis, California / Q000151:congenital* / Q000635:transmission; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D018062:La Crosse virus; D011247:Pregnancy; D014903:West Virginia
chemical_list: D007075:Immunoglobulin M