title: Endoscopic survey of low-dose-aspirin-induced gastroduodenal mucosal injuries in patients with ischemic heart disease.
abstract: OBJECTIVE
  Low-dose aspirin is effective for the prevention of cardiovascular and cerebrovascular events, but the frequency of gastrointestinal injuries among users of low-dose aspirin in Japan is currently unknown. In the present study endoscopic examination was performed to investigate the frequency of gastroduodenal injuries associated with low-dose aspirin in patients with ischemic heart disease (IHD).
  
  
  METHODS
  Screening upper endoscopic examinations were prospectively performed on 131 patients with IHD who were not receiving antiulcer treatment. Endoscopic findings such as ulcers and flat erosions were assessed as mucosal injuries.
  
  
  RESULTS
  Mucosal injuries were found in 62 of 101 (61.4%) low-dose aspirin users and three of 30 (10%) nonaspirin users. There were significantly more mucosal injuries among low-dose aspirin users than among the non-users (P<0.0001). Gastroduodenal ulcers were found in 19 of 101 (18.8%) low-dose aspirin users compared with one of 30 (3.3%) nonaspirin users. The frequency of mucosal injuries was not associated with the duration of aspirin treatment.
  
  
  CONCLUSIONS
  Endoscopy frequently reveals low-dose aspirin-induced gastroduodenal injuries in patients with IHD.
authors.affiliation: Department of Gastroenterology, Hokko Memorial Hospital, Sapporo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nema
authors.forename: Mototsugu
authors.initials: M
authors.lastname: Kato
authors.forename: Takehiko
authors.initials: T
authors.lastname: Katsurada
authors.forename: Youichi
authors.initials: Y
authors.lastname: Nozaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yotsukura
authors.forename: Izumi
authors.initials: I
authors.lastname: Yoshida
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Sato
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kawai
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Takagi
authors.forename: Takanori
authors.initials: T
authors.lastname: Okusa
authors.forename: Shunichi
authors.initials: S
authors.lastname: Takiguchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sakurai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Asaka
mesh_terms: D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D016022:Case-Control Studies; D004334:Drug Administration Schedule; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000473:pathology; D004384:Duodenoscopy; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D005773:Gastroscopy; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin