Laminar and compartmental regulation of dendritic growth in mature cortex.
Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.
Chow
David K
DK
Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles Young Drive, South, Los Angeles, California 90095-1761, USA.
Groszer
Matthias
M
Pribadi
Mochtar
M
Machniki
Michal
M
Carmichael
S Thomas
ST
Liu
Xin
X
Trachtenberg
Joshua T
JT
D000367:Age Factors; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development / Q000502:physiology; D003712:Dendrites / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D017966:Pyramidal Cells / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases
D000903:Antibiotics, Antineoplastic; D002352:Carrier Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor); C546842:MTOR protein, human; C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases; D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse; D020123:Sirolimus