title: Distribution of thietazole in organs and tissues of rats after single and repeated administration.
abstract: We studied the kinetics of thietazole distribution in the liver, brain, kidneys, spleen, heart, skeletal muscles, lungs, adipose tissue, and testicles after single and repeated administration of this drug. Single and repeated administration of thietazole was followed by elimination of this drug from the blood into organs and tissues. After repeated administration, thietazole was selectively accumulated in the spleen.
authors.affiliation: All-Russian Research Center on Safety of Biologically Active Substances, Staraya Kupavna, Russia. nauka@materiamedica.ru
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: I L
authors.initials: IL
authors.lastname: Gulyaeva
mesh_terms: D000085:Acetates / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier; D007155:Immunologic Factors / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D000085:Acetates; D001562:Benzimidazoles; D007155:Immunologic Factors; C465426:thietasol