title: Macrophage inhibitory cytokine-1: a new player in melanoma development.
abstract: Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the TGF-beta superfamily. Although it has been reported to exhibit both tumorigenic and antitumorigenic activities, Boyle et al. report in this issue that MIC-1 expression was correlated with the tumorigenicity of melanoma cells. The elucidation of signaling pathways around MIC-1 might contribute to prospective targeting therapy for melanoma.
authors.affiliation: Department of Dermatology, Sapporo Medical University, Sapporo, Japan. yamasita@sapmed.ac.jp
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Yamashita
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yoneta
authors.forename: Tokimasa
authors.initials: T
authors.lastname: Hida
mesh_terms: D015972:Gene Expression Regulation, Neoplastic; D055436:Growth Differentiation Factor 15 / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000276:immunology*; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology*
chemical_list: C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15