Epithelial function in eosinophilic gastrointestinal diseases.
Eosinophilic gastrointestinal diseases (EGIDs) are characterized by a wide variety of gastrointestinal symptoms that occur in conjunction with increased numbers of eosinophils in intestinal tissues. With the precise role or roles of eosinophils in gastrointestinal dysfunction incompletely understood, this subject remains an area of intense investigation. Most studies suggest that the intimate anatomic association of eosinophils with the intestinal epithelium implicates participation in the pathophysiology of EGIDs. This article reviews the limited evidence suggesting that the epithelium and eosinophils interact in the gastrointestinal tract and in other organ systems and describes how the epithelium and eosinophils might participate in gastrointestinal inflammatory diseases.
Fillon
Sophie
S
Section of Pediatric Gastroenterology, Hepatology and Nutrition, University of Colorado Denver School of Medicine, 13123 East 16th Avenue, B290, Aurora, CO 80045, USA.
Robinson
Zachary D
ZD
Colgan
Sean P
SP
Furuta
Glenn T
GT
D000818:Animals; D002450:Cell Communication; D002465:Cell Movement; D003602:Cytotoxicity, Immunologic; D047150:Eosinophil Cationic Protein / Q000276:immunology; D004802:Eosinophilia / Q000276:immunology / Q000473:pathology*; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004847:Epithelial Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000473:pathology*; D006801:Humans; D018793:Interleukin-13 / Q000276:immunology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000276:immunology
D018793:Interleukin-13; D016212:Transforming Growth Factor beta; D047150:Eosinophil Cationic Protein