[Advances in the study of small peptides in targeted drug delivery system].
Recently various peptide receptors which displayed the highest binding affinity and specificity with their peptide ligands by ligand-receptor have been exploited to develop drug delivery system which can directionally deliver drug to targeted cell. It is significant to study and applicate, including targeted drug delivery system mediated by bombesin receptor, somatostatin receptor, SynB3 receptor, LH-RH receptor and other peptide receptor, et al. Several small peptide fragments were selected as carriers radicals combining doxorubicin, 2-pyrrolino-DOX, methotrexate, cis-platinum, and camptothecin to form hybrid cytotoxic analogs. These highly potent cytotoxic analogs have been designed as targeted anti-tumor agents for the treatment and study of various cancers that possess receptors for the carrier peptide.
Sun
Yan
Y
College of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Wang
Chi
C
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004317:Doxorubicin / Q000031:analogs & derivatives / Q000627:therapeutic use; D016503:Drug Delivery Systems; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism*; D011758:Pyrroles / Q000627:therapeutic use; D018004:Receptors, Bombesin / Q000378:metabolism*; D011966:Receptors, LHRH / Q000378:metabolism*; D017481:Receptors, Somatostatin / Q000378:metabolism*
D000970:Antineoplastic Agents; D009842:Oligopeptides; D011758:Pyrroles; D018004:Receptors, Bombesin; D011966:Receptors, LHRH; D017481:Receptors, Somatostatin; C501559:SynB3 peptide; C098751:AN 204; D004317:Doxorubicin