title: Evaluation of serum cystatin-C in dogs with visceral leishmaniasis.
abstract: Serum Cystatin C (sCys-C) is one of the most important serum markers of renal function assessment in dogs. The purpose of this study was to determine the sCys-C concentration in dogs with visceral leishmaniasis (VL). In the study, 16 dogs with VL and 10 clinical healty dogs (control) were used. Mean sCys-C concentration of the infected dogs was significantly higher than that of the control group (p < 0.05). Mean serum creatinine concentration was lower and mean blood urea nitrogen, albumin and globulin concentrations were higher in dogs with VL; however, these changes were not statistically significant. Mean total protein and phosphorus concentrations were found to be higher in dogs with VL than healthy dogs (p < 0.05). No significant correlation had been determined between sCys-C and other variables. Visceral leishmaniasis in dogs has increased sCys-C concentration indicating a possible renal impairment; however, further studies are needed to be performed together with renal biopsies in the investigation sCys-C in dogs with VL.
authors.affiliation: Department of Internal Medicine, Adnan Menderes University, Aydin, Turkey. pasaserdar@yahoo.co.uk
authors.forename: S
authors.initials: S
authors.lastname: Pasa
authors.forename: G
authors.initials: G
authors.lastname: Bayramli
authors.forename: A
authors.initials: A
authors.lastname: Atasoy
authors.forename: A
authors.initials: A
authors.lastname: Karul
authors.forename: S
authors.initials: S
authors.lastname: Ertug
authors.forename: S
authors.initials: S
authors.lastname: Ozensoy Toz
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D055316:Cystatin C / Q000097:blood*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000662:veterinary*; D008297:Male; D051437:Renal Insufficiency / Q000097:blood / Q000662:veterinary*
chemical_list: D015415:Biomarkers; D055316:Cystatin C