title: Acute efficacy of low-dose human atrial natriuretic peptide monotherapy without loop diuretics for acute decompensated heart failure with left ventricular systolic dysfunction: a case report.
abstract: A 64-year-old man was admitted to our hospital with new-onset acute decompensated heart failure (ADHF). He had left ventricular systolic dysfunction and chronic atrial fibrillation with a rapid ventricular response. Initial treatment with low-dose recombinant human atrial natriuretic peptide (hANP) alone and no loop diuretics had an immediate effect on ADHF and left ventricular systolic dysfunction. This case demonstrates that low-dose hANP (0.01 microg/kg/min) monotherapy can be safe and effective for ADHF, with no loop diuretics being required during hospitalization. However, clinical trials will be needed to further evaluate the acute efficacy and safety of hANP monotherapy in patients with ADHF.
authors.forename: Koichi
authors.initials: K
authors.lastname: Shimamura
authors.forename: Katsuya
authors.initials: K
authors.lastname: Kajimoto
mesh_terms: D000208:Acute Disease; D009320:Atrial Natriuretic Factor / Q000008:administration & dosage*; D054143:Heart Failure, Systolic / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D049994:Sodium Potassium Chloride Symporter Inhibitors; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*
chemical_list: C472955:NPPA protein, human; D049994:Sodium Potassium Chloride Symporter Inhibitors; D009320:Atrial Natriuretic Factor