Survival, complications, and analysis of risk factors after renal transplantation in cats.
OBJECTIVE
To report survival, complications, and analyze risk factors for survival after renal transplantation (RTr) and cyclosporine-A based immunosuppression in cats.


METHODS
Historical cohort.


METHODS
Cats (n=60).


METHODS
Data were obtained from medical records of cats that had RTr. Influence of various perioperative factors on survival and complications was evaluated. Occurrence of postoperative hypertension (HT), seizures, infection, acute allograft rejection (AR), congestive heart failure (CHF), and delayed graft function (DGF) was evaluated.


RESULTS
Survival to discharge after RTr was 77.5%. Estimated median overall survival time was 613 days; 6 month and 3 year overall survival proportions were 65% and 40%, respectively. Age, weight, and blood pressure influenced overall survival. Increased preoperative creatinine concentration, blood urea nitrogen, postoperative creatinine concentration, left ventricular wall thickness, and reduced creatinine reduction ratio influenced survival until discharge. HT was identified in 9/30 (30%) cats; however, no risk factors were identified, nor was HT related to seizures. AR was identified in 8/62 (13%) grafts. Infection, predominantly bacterial, developed in 22/60 (37%) cats. CHF occurred in 7/60 (12%) cats before discharge. Cats experiencing CHF were younger, had an increased incidence of heart murmurs, and poor initial graft function. DGF was identified in 5 cats and seizures in 2 cats.


CONCLUSIONS
RTr affords cats with CRF long survival times. Older cats and cats with severe azotemia, HT, and cardiovascular disease may have increased mortality after RTr. Complications after RTr were common.


CONCLUSIONS
Clinicians should be aware of these risk factors when recommending feline RTr.
Schmiedt
Chad W
CW
Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706-1100, USA.
Holzman
Gerianne
G
Schwarz
Tobias
T
McAnulty
Jonathan F
JF
D000367:Age Factors; D000818:Animals; D053099:Azotemia / Q000150:complications / Q000662:veterinary; D001806:Blood Urea Nitrogen; D002318:Cardiovascular Diseases / Q000150:complications / Q000662:veterinary; D002371:Cat Diseases / Q000401:mortality* / Q000601:surgery*; D002415:Cats; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology / Q000662:veterinary; D006973:Hypertension / Q000150:complications / Q000662:veterinary; D016030:Kidney Transplantation / Q000401:mortality / Q000662:veterinary*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology / Q000401:mortality / Q000662:veterinary*; D011237:Predictive Value of Tests; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors
D003404:Creatinine