[Neuroimmunocorrection therapy for the prophylaxis of infectious complications in acute stroke patients].
Neuroimmunocorrection therapy with cerebrolysin has been used for the prophylaxis of clinical pneumonia development in the early stage of acute stroke in a group of 140 patients with heavy clinical course of acute ischemic stroke (AIS). All patients in the test and control groups received the basal anti-AIS therapy and antibacterial drugs (IV-generation cephalosporins) in case of pneumonia development. The efficacy of cerebrolysin administration was evaluated both on the clinical scale (NIH-NINDS, CPIS, SIRS immonograms) and using laboratory indices. It is established that the proposed neuroimmunocorrection therapy with cerebrolysin decreases the frequency of the clinical pneumonia development. A relationship between the pneumonia onset rate and the focus localization in limbico-diencephalic part of the brain is established. The use of cerebrolysin decreases lethality, normalizes the impaired immunity indices, accelerates the restoration of violated neural functions, suppresses pneumonia development, restores the level of albumin, and normalizes the laboratory indices of inflammatory syndrome.
Kul'chikov
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AE
Makarenko
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AN
D000368:Aged; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003428:Cross Infection / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D004359:Drug Therapy, Combination; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D015213:Neuroimmunomodulation / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018410:Pneumonia, Bacterial / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D012709:Serum Albumin; D020521:Stroke / Q000097:blood / Q000150:complications / Q000276:immunology; D016896:Treatment Outcome
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D018696:Neuroprotective Agents; D012709:Serum Albumin; C006952:cerebrolysin