[Effect of taurine on the ion transport system in mitochondria].
The influence of taurine on the ATP-dependent mitochondrial swelling, which characterizes the activity of the ATP-dependent K+ channel and the opening of Ca(2+)-dependent pores differing in the sensitivity to cyclosporin A in rat liver mitochondria has been studied. It was shown that taurine at small (0.5-125 microM) concentrations produces a stimulating effect on the ATP-dependent mitochondrial swelling. Taurine in physiological concentrations (0.5-20 mM) di not affect the ATP-dependent mitochondrial swelling and cyclosporin A-insensitive palmitate/Ca(2+)-activated pore formation in mitochondria. Taurine in these concentrations increased the rate of cyclosporin A-sensitive swelling induced by Ca2+ and P(i) and decreased the Ca2+ capacity of mitochondria.
Murzaeva
S V
SV
Belosludtseva
N V
NV
Gavrovskaia
L
L
Mironova
G D
GD
D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002118:Calcium / Q000502:physiology; D002414:Cations, Monovalent; D016572:Cyclosporine / Q000494:pharmacology; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D017136:Ion Transport; D008930:Mitochondria, Liver / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism; D000083162:Mitochondrial Permeability Transition Pore; D008933:Mitochondrial Swelling; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013654:Taurine / Q000494:pharmacology / Q000502:physiology*
D002414:Cations, Monovalent; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D013654:Taurine; D016572:Cyclosporine; D000255:Adenosine Triphosphate; D011188:Potassium; D002118:Calcium