Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion.
OBJECTIVE
To investigate the association of vascular endothelial growth factor (VEGF) polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) with idiopathic recurrent spontaneous abortion (RSA) in Koreans.


METHODS
Prospective case-control study.


METHODS
University-based hospital.


METHODS
Two hundred and fifteen patients with a history of two or more unexplained consecutive pregnancy losses and 113 healthy controls with at least one live birth and no history of pregnancy loss.


METHODS
None.


METHODS
Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses were performed for the -2578C>A and 936C>T genotypes. Real-time PCR was also used to analyze the -1154G>A and -634G>C genotypes.


RESULTS
The GA (adjusted odds ratio [AOR] 2.774; 95% confidence interval [CI] 1.512-5.092) genotype of the VEGF -1154G>A polymorphism was significantly different between women with idiopathic RSA and controls. The difference in overall (GA + AA) frequency was also marginally significant between the controls and patients with idiopathic RSA (AOR, 2.006; 95% CI, 1.158-3.473). The differences in frequencies of the A-A-G-T and C-A-G-T haplotypes of the VEGF polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) were marginally significant between the patient and control groups.


CONCLUSIONS
This study suggests that VEGF polymorphisms and haplotypes are a genetic determinant for the risk of idiopathic RSA in Korean women.
Lee
Hyun Haing
HH
Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seongnam, South Korea.
Hong
Seung Ho
SH
Shin
Seung Ju
SJ
Ko
Jung Jae
JJ
Oh
Doyeun
D
Kim
Nam Keun
NK
D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007723:Korea / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult
D042461:Vascular Endothelial Growth Factor A