In vitro comparison of the efficacies of natamycin and silver nitrate against ocular fungi.
The in vitro activity of the silver nitrate was assessed in comparison with that of natamycin against 128 corneal Fusarium isolates and 90 corneal Aspergillus isolates. MIC(90)s of silver nitrate were 2 microg/ml for Fusarium spp. and 1 microg/ml for Aspergillus spp. MIC(90)s of natamycin were 8 microg/ml for Fusarium spp. and 32 microg/ml for Aspergillus spp. Silver nitrate exhibited potent antifungal activity against ocular fungi in vitro.
Xu
Yan
Y
Department of Ocular Pharmacology, Henan Institute of Ophthalmology, Zhengzhou, China. xuyan990301@yahoo.com.cn
Pang
Guangren
G
Gao
Chuanwen
C
Zhao
Dongqing
D
Zhou
Lutan
L
Sun
Shengtao
S
Wang
Bingliang
B
D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D005123:Eye; D015821:Eye Infections, Fungal / Q000382:microbiology*; D005670:Fusarium / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010866:Natamycin / Q000494:pharmacology*; D012835:Silver Nitrate / Q000494:pharmacology*
D000935:Antifungal Agents; D010866:Natamycin; D012835:Silver Nitrate