Contribution of peroxisomes to penicillin biosynthesis in Aspergillus nidulans.
Peroxisomal localization of the third enzyme of the penicillin biosynthesis pathway of Aspergillus nidulans, acyl-coenzyme A:IPN acyltransferase (IAT), is mediated by its atypical peroxisomal targeting signal 1 (PTS1). However, mislocalization of IAT by deletion of either its PTS1 or of genes encoding proteins involved in peroxisome formation or transport does not completely abolish penicillin biosynthesis. This is in contrast to the effects of IAT mislocalization in Penicillium chrysogenum.
Spröte
Petra
P
Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology (HKI), Jena, Germany.
Brakhage
Axel A
AA
Hynes
Michael J
MJ
D000217:Acyltransferases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001233:Aspergillus nidulans / Q000737:chemistry / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D008969:Molecular Sequence Data; D010406:Penicillins / Q000096:biosynthesis*; D020675:Peroxisomes / Q000737:chemistry / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005656:Fungal Proteins; D010406:Penicillins; D000217:Acyltransferases