title: Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl.
abstract: A 15-year-old girl presented with pain in the right ear and acute onset of total peripheral facial nerve palsy. Imaging studies revealed an intracranial mass of the right temporal bone causing temporal lobe displacement. A first biopsy led to the diagnosis of intracranial giant cell reparative granuloma (GCRG), a rare benign tumor of the bone or soft tissue that can show expansive growth. The etiology of GCRG is unclear. Facial nerve palsy responded to treatment with diclofenac and physiotherapy, however, the intracranial lesion progressed at follow-up. Total surgical excision revealed a cholesteatoma central to the GCRG originating from the right middle ear and mastoid. Cholesteatoma should be considered as a trigger for intracranial GCRG growth, especially if adjacent to the temporal bone.
authors.affiliation: Division of Pediatric Hematology/Oncology, University Clinic of Pediatrics and Adolescent Medicine, Medical University Graz, Austria. andrea.moser@klinikum-graz.at
authors.forename: Andrea
authors.initials: A
authors.lastname: Moser
authors.forename: Karl M
authors.initials: KM
authors.lastname: Hoffmann
authors.forename: Christian
authors.initials: C
authors.lastname: Walch
authors.forename: Petra
authors.initials: P
authors.lastname: Sovinz
authors.forename: Herwig
authors.initials: H
authors.lastname: Lackner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schwinger
authors.forename: Martin
authors.initials: M
authors.lastname: Benesch
authors.forename: Gerald
authors.initials: G
authors.lastname: Fritz
authors.forename: Christian
authors.initials: C
authors.lastname: Urban
mesh_terms: D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001847:Bone Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018424:Cholesteatoma, Middle Ear / Q000150:complications* / Q000473:pathology / Q000601:surgery; D004008:Diclofenac / Q000627:therapeutic use; D005158:Facial Paralysis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006101:Granuloma, Giant Cell / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D013701:Temporal Bone; D014057:Tomography, X-Ray Computed
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac