title: Seasonal and regional contributors of 1-hydroxypyrene among children near a steel mill.
abstract: Urinary 1-hydroxypyrene (1-OHP) is a biomarker of exposure to polycyclic aromatic hydrocarbons (PAH). Effect of residence on children's PAH exposure was reported among children living near a polluted area. Instead of a snapshot assessment, however, a temporal history of exposure characteristics needs to be assessed in the studies of chronic disease development such as cancer. The urinary 1-OHP measurements were repeated to determine regional effect of ambient air pollution on 1-OHP levels over extended periods. Two sites were chosen: (a) one site located near the steel mill ("nearby" site) and (b) the other site located at a longer distance from the mill ("remote" site). Spot urinary 1-OHP levels were measured from 72 children for 3 consecutive days per month, repeated over 9-month period. Compared with remote site, the nearby site had increased the urinary 1-OHP level by 62.3% [95% confidence interval (95% CI), 39.8-88.3%]. Other statistically significant factors that contributed to the level include sex [16.5% (95% CI, 1.2-34.1%) higher for girls than boys], consumption of charbroiled meat [16.5% (95% CI, 1.1-34.2%) higher], and an increase in PM(10) [10.1% (95% CI, 4.8-15.7%) higher for the interquartile range increment]. Controlling for covariates, the 1-OHP levels were increased in the summer and fall compared with winter. The magnitude of the effects of both seasons had diminished after adjusting for PM(10). This is the first report providing seasonal and regional contributors to environmental PAH exposure, assessed by urinary 1-OHP, with higher 1-OHP levels during summer when ambient pollution was also high.
authors.affiliation: Department of Environmental Health, Graduate School of Public Health and Institute of Health and Environment, Seoul National University, 28 Yeongeon-Dong, Jongno-Gu, Seoul 110-460, Republic of Korea.
authors.forename: Mi-Sun
authors.initials: MS
authors.lastname: Lee
authors.forename: Ki-Do
authors.initials: KD
authors.lastname: Eum
authors.forename: Kiyoung
authors.initials: K
authors.lastname: Lee
authors.forename: Ho
authors.initials: H
authors.lastname: Kim
authors.forename: Domyung
authors.initials: D
authors.lastname: Paek
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000652:urine*; D002648:Child; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D005260:Female; D006801:Humans; D007723:Korea; D008297:Male; D008669:Metallurgy; D052638:Particulate Matter / Q000633:toxicity / Q000652:urine; D011721:Pyrenes; D012621:Seasons; D013232:Steel
chemical_list: D015415:Biomarkers; D052638:Particulate Matter; D011721:Pyrenes; D013232:Steel; C033146:1-hydroxypyrene