title: The ESCRT machinery: new functions in viral and cellular biology.
abstract: The ESCRT (endosomal sorting complex required for transport) machinery consists of a number of cytosolic proteins that make up three functional subcomplexes: ESCRT-I, ESCRT-II and ESCRT-III. These proteins function in multivesicular body formation and cell division and are co-opted by enveloped retroviruses to facilitate viral egress. Analysis of these functions may help illuminate conserved mechanisms of ESCRT function.
authors.affiliation: Department of Infectious Disease, King's College London School of Medicine, Guy's Hospital, London SE1 9RT, UK.
authors.forename: Jeremy G
authors.initials: JG
authors.lastname: Carlton
authors.forename: Juan
authors.initials: J
authors.lastname: Martin-Serrano
mesh_terms: D011992:Endosomes / Q000378:metabolism*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D021381:Protein Transport; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D046912:Multiprotein Complexes