title: Syntheses and doxorubicin-inclusion abilities of beta-cyclodextrin derivatives with a hydroquinone alpha-glycoside residue attached at the primary side.
abstract: This paper describes syntheses and doxorubicin-inclusion abilities of beta-cyclodextrin (CyD) derivatives with a hydroquinone alpha-glycoside residue attached at the primary side. The hydroquinone glycoside having an alpha-D-glucosidic or 2-acetamido-2-deoxy-alpha-D-glucosidic linkage became a useful component for providing an alpha-D-glucose- or 2-acetamido-2-deoxy-alpha-D-glucose-beta-CyD conjugate. The surface plasmon resonance analyses of these beta-CyD derivatives for the anticancer agent, doxorubicin, indicated that they had excellent inclusion associations on the order of 10(5 m)-1 for the immobilized doxorubicin.
authors.affiliation: The Noguchi Institute, Tokyo, Japan.
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Oda
authors.forename: Masumi
authors.initials: M
authors.lastname: Miura
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Hattori
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamanoi
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry*; D006873:Hydroquinones / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000903:Antibiotics, Antineoplastic; D004337:Drug Carriers; D006027:Glycosides; D006873:Hydroquinones; D047392:beta-Cyclodextrins; D004317:Doxorubicin; C031927:hydroquinone