Tuberous sclerosis complex with unilateral perisylvian polymicrogyria and contralateral hippocampal sclerosis - a case report.
Malformations of cortical development (MCD) encompass a wide spectrum of brain disorders. Although rare, the combination of certain MCD may occur. We report a rare case of combination of three distinct cerebral pathologies: tuberous sclerosis, polymicrogyria and hippocampal sclerosis in a patient with intractable epilepsy. Ictal EEG and ictal SPECT suggested right perisylvian area as a seizure onset zone. However, on MRI multiple potentially epileptogenic lesions were identified. The neurobiological background of the coexistence of different types of malformations of cortical development remains enigmatic.
Helbok
R
R
Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. raimund.helbok@uki.at
Kuchukhidze
G
G
Unterberger
I
I
Koppelstaetter
F
F
Dobesberger
J
J
Donnemiller
E
E
Trinka
E
E
D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D055909:Magnetic Field Therapy; D054220:Malformations of Cortical Development / Q000150:complications* / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014402:Tuberous Sclerosis / Q000150:complications* / Q000000981:diagnostic imaging; D055815:Young Adult