Premenstrual mood symptoms: study of familiality and personality correlates in mood disorder pedigrees.
We sought to determine whether premenstrual mood symptoms exhibit familial aggregation in bipolar disorder or major depression pedigrees. Two thousand eight hundred seventy-six women were interviewed with the Diagnostic Interview for Genetic Studies as part of either the NIMH Genetics Initiative Bipolar Disorder Collaborative study or the Genetics of Early Onset Major Depression (GenRED) study and asked whether they had experienced severe mood symptoms premenstrually. In families with two or more female siblings with bipolar disorder (BP) or major depressive disorder (MDD), we examined the odds of having premenstrual mood symptoms given one or more siblings with these symptoms. For the GenRED MDD sample we also assessed the impact of personality as measured by the NEO-FFI. Premenstrual mood symptoms did not exhibit familial aggregation in families with BP or MDD. We unexpectedly found an association between high NEO openness scores and premenstrual mood symptoms, but neither this factor, nor NEO neuroticism influenced evidence for familial aggregation of symptoms. Limitations include the retrospective interview, the lack of data on premenstrual dysphoric disorder, and the inability to control for factors such as medication use.
Payne
Jennifer L
JL
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, 550 N. Broadway, Baltimore, MD 21205, USA. jpayne5@jhmi.edu
Klein
Sarah R
SR
Zamoiski
Rachel B
RB
Zandi
Peter P
PP
Bienvenu
Oscar J
OJ
Mackinnon
Dean F
DF
Mondimore
Francis M
FM
Schweizer
Barbara
B
Swartz
Karen L
KL
Crowe
Raymond P
RP
Scheftner
William A
WA
Weissman
Myrna M
MM
Levinson
Douglas F
DF
DePaulo
J Raymond
JR
Potash
James B
JB
D000328:Adult; D001714:Bipolar Disorder; D003865:Major Depressive Disorder / Q000235:genetics / Q000523:psychology; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D019964:Mood Disorders / Q000235:genetics* / Q000503:physiopathology*; D016017:Odds Ratio; D010375:Pedigree; D010551:Personality; D011293:Premenstrual Syndrome / Q000235:genetics* / Q000523:psychology; D014481:United States