title: Plasma-treated silk fibroin nanofibers for skin regeneration.
abstract: Silk fibroin (SF) nanofibers were prepared by electrospinning and treated with plasma in the presence of oxygen or methane gas to modify their surface characteristics. The surface characteristics of the SF nanofibers after plasma treatment were examined using contact angle measurements and XPS analysis. The hydrophilicity of the electrospun SF nanofibers decreased slightly by the CH(4) plasma treatment. On the other hand, the hydrophilicity of the SF nanofibers increased greatly by an O(2) plasma treatment. The O(2)-treated SF nanofibers showed higher cellular activities for both normal human epidermal keratinocytes (NHEK) and fibroblasts (NHEF) than the untreated ones.
authors.affiliation: Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Lim
authors.initials: L
authors.lastname: Jeong
authors.forename: In-Sung
authors.initials: IS
authors.lastname: Yeo
authors.forename: Ha Na
authors.initials: HN
authors.lastname: Kim
authors.forename: Young Il
authors.initials: YI
authors.lastname: Yoon
authors.forename: Da Hyun
authors.initials: DH
authors.lastname: Jang
authors.forename: Sung Youn
authors.initials: SY
authors.lastname: Jung
authors.forename: Byung-Moo
authors.initials: BM
authors.lastname: Min
authors.forename: Won Ho
authors.initials: WH
authors.lastname: Park
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002675:Child, Preschool; D004602:Elements; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005349:Fibroins / Q000494:pharmacology* / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010949:Plasma / Q000737:chemistry*; D012038:Regeneration / Q000187:drug effects*; D047011:Silk / Q000737:chemistry / Q000494:pharmacology* / Q000648:ultrastructure; D012867:Skin / Q000187:drug effects*; D013057:Spectrum Analysis; D013499:Surface Properties / Q000187:drug effects; D013997:Time Factors; D014867:Water
chemical_list: D004602:Elements; D047011:Silk; D014867:Water; D005349:Fibroins