title: Recurrence of a laryngeal spindle cell sarcoma with a transformation into a higher grade of malignancy.
abstract: Primary malignant mesenchymal neoplasms of the larynx are rare. Sarcomas of the larynx account for <1% of all malignant laryngeal mesenchymal neoplasms. This report examines a case of a recurring laryngeal, initial benign-appearing mesenchymal tumour, which first changed its clinical phenotype without any histological signs of malignancy and later also its histological appearance with signs of malignancy. Finally, it even underwent a transformation into a higher grade of malignancy. In addition to this, the difficulties of allocating this tumour to the correct sarcoma subentity are shown.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Mainz, School of Medicine, Mainz, Germany. fruth@hno.klinik.uni-mainz.de
authors.forename: K
authors.initials: K
authors.lastname: Fruth
authors.forename: T
authors.initials: T
authors.lastname: Hansen
authors.forename: D
authors.initials: D
authors.lastname: Katenkamp
authors.forename: W
authors.initials: W
authors.lastname: Mann
authors.forename: B M
authors.initials: BM
authors.lastname: Lippert
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000601:surgery*; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000473:pathology* / Q000601:surgery*