Autologous stem cell transplantation using MEAM regimen for relapsed AIDS-related lymphoma patients who received highly active anti-retroviral therapy: a report of three cases.
AIDS-related lymphoma (ARL) is a serious complication of HIV infection. We performed MEAM (MCNU + etoposide + cytarabine + L-PAM) regimen with autologous stem cell transplantation (ASCT) for three patients with refractory or relapsed ARL. All three patients had been treated with highly active anti-retroviral therapy (HAART) during the course of the treatment regimen and ASCT. The regimen was well tolerable, and no uncontrollable infection was noted. All patients are still alive and maintain complete remission at 24, 20 and 9 months after transplantation. ASCT using MEAM regimen as a conditioning regimen was feasible for our patients with refractory or relapsed ARL.
Kawabata
Kimihito C
KC
Division of Hematology, Internal Medicine, International Medical Center of JAPAN, Tokyo, Japan.
Hagiwara
Shotaro
S
Takenouchi
Ayako
A
Tanimura
Akira
A
Tanuma
Junko
J
Tachikawa
Natsuo
N
Miwa
Akiyoshi
A
Oka
Shinichi
S
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active; D003561:Cytarabine / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000628:therapy*; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D012008:Recurrence; D016879:Salvage Therapy; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods*; D014182:Transplantation, Autologous
D009607:Nitrosourea Compounds; D003561:Cytarabine; D005047:Etoposide; D008558:Melphalan; C020766:ranimustine