title: Effects of GSM-modulated radiofrequency electromagnetic fields on mouse bone marrow cells.
abstract: We examined the effects of in vivo exposure to a GSM-modulated 900 MHz RF field on the ability of bone marrow cells to differentiate, colonize lymphatic organs, and rescue lethally X-irradiated mice from death. X-irradiated mice were injected with medium alone or containing bone marrow cells from either RF-field-exposed (SAR 2 W/kg, 2 h/day, 5 days/ week, 4 weeks) or sham-exposed or cage control donor mice. Whereas all mice injected with medium alone died, mice that received bone marrow cells survived. Three and 6 weeks after bone marrow cell transplantation, no differences in thymus cellularity and in the frequencies of differentiating cell subpopulations (identified by CD4/CD8 expression) were observed among the three transplanted groups. Mitogen-induced thymocyte proliferation yielded comparable levels in all transplanted groups. As to the spleen, no effects of the RF-field exposure on cell number, percentages of B and T (CD4 and CD8) cells, B- and T-cell proliferation, and IFN-gamma production were found in transplanted mice. In conclusion, our results show no effect of in vivo exposure to GSM-modulated RF fields on the ability of bone marrow precursor cells to home and colonize lymphoid organs and differentiate in phenotypically and functionally mature T and B lymphocytes.
authors.affiliation: Italian Agency for New Technologies, Environment and Energy, Rome, Italy.
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Prisco
authors.forename: Francesca
authors.initials: F
authors.lastname: Nasta
authors.forename: Maria Manuela
authors.initials: MM
authors.lastname: Rosado
authors.forename: Giorgio Alfonso
authors.initials: GA
authors.lastname: Lovisolo
authors.forename: Carmela
authors.initials: C
authors.lastname: Marino
authors.forename: Claudio
authors.initials: C
authors.lastname: Pioli
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000528:radiation effects; D001854:Bone Marrow Cells / Q000378:metabolism / Q000528:radiation effects*; D016026:Bone Marrow Transplantation; D002452:Cell Count; D002454:Cell Differentiation / Q000528:radiation effects; D049109:Cell Proliferation / Q000528:radiation effects; D004574:Electromagnetic Fields; D005260:Female; D051379:Mice; D011846:Radio Waves; D013154:Spleen / Q000166:cytology / Q000528:radiation effects; D015996:Survival Rate; D013601:T-Lymphocytes / Q000166:cytology / Q000528:radiation effects; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects