title: Drugs for the treatment of diabetes complications. Zycose: a new player in the field?
abstract: Zycose is a newly released (2006) combined medication containing folic acid (1 mg) benfotiamine (150 mg) and benzamine (850 mg), a proprietary blend of para-aminobenzoic acid (PABA), vitamin E and alpha-lipoic acid (ALA). Zycose protects vascular, retinal and kidney function by improving cellular health and promoting peripheral nerve health in people with diabetes. Zycose's therapeutic benefit is believed to be due to the additive effects of its compounds on lowering homocysteine levels (folic acid), reducing the production of advanced glycation end products (benfotiamine), improving endothelial function (folic acid, benfotiamine, ALA), reducing oxidative stress (ALA, vitamin E) and reducing carbonyl stress (benzamine). The complex composition of Zycose allows the therapeutic intervention of several hyperglycemiamediated disorders. The compound consists mainly of vitamins, therefore explaining, in part, the good safety profile and reduced adverse effects.
authors.affiliation: Diabetes Clinic at the Heart and Diabetes Center North Rhine-Westphalia Ruhr-University Bochum, Bad Oeynhausen, Germany. astirban@hdz-nrw.de
authors.forename: Alin
authors.initials: A
authors.lastname: Stirban
mesh_terms: D010129:4-Aminobenzoic Acid / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D002986:Clinical Trials as Topic; D048909:Diabetes Complications / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004338:Drug Combinations; D005492:Folic Acid / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D013831:Thiamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D008063:Thioctic Acid / Q000737:chemistry / Q000627:therapeutic use; D014810:Vitamin E / Q000737:chemistry / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D014815:Vitamins; C539260:alpha-lipoic acid, 4-aminobenzoic acid, aniline, benfotiamine, thioctic Acid, vitamin E drug combination; D014810:Vitamin E; D008063:Thioctic Acid; D005492:Folic Acid; D010129:4-Aminobenzoic Acid; D013831:Thiamine