Nanofabricated upconversion nanoparticles for photodynamic therapy.
We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.
Ungun
Baris
B
Department of Chemical Engineering, Princeton University, Princeton, NJ, USA.
Prud'homme
Robert K
RK
Budijon
Stephanie J
SJ
Shan
Jingning
J
Lim
Shuang F
SF
Ju
Yiguang
Y
Austin
Robert
R
D001672:Biocompatible Materials; D006801:Humans; D008027:Light; D008674:Metals, Rare Earth / Q000528:radiation effects; D012157:Mononuclear Phagocyte System / Q000502:physiology* / Q000528:radiation effects; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D010778:Photochemotherapy / Q000295:instrumentation* / Q000379:methods*; D017785:Photons; D017319:Photosensitizing Agents; D011092:Polyethylene Glycols; D011166:Porphyrins; D026082:Singlet Oxygen / Q000032:analysis
D001672:Biocompatible Materials; D008674:Metals, Rare Earth; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen; D011092:Polyethylene Glycols