title: Glioblastoma multiforme in children: experience at Hospital Infantil de Mexico Federico Gomez.
abstract: OBJECTIVE
  To evaluate clinical evolution of pediatric patients diagnosed with glioblastoma multiforme (GBM) at Hospital Infantil de México Federico Gómez.
  
  
  METHODS
  Cases of patients treated from January to May, 2007, were included in this study. Variables analyzed were: age, diagnosis, size of tumor, histopathological description, degree of resection, time of stay in hospital, complications and outcome using Pearson's chi-squared test and logistic regression.
  
  
  CONCLUSIONS
  Sixteen patients were identified. Mean age of presentation was 8.8. An increased frequency of complications was observed in younger patients and longer survival rates in patients with greater resections; main mode of presentation was directly related to intracranial hypertension; size of tumor was not related to evolution or outcome. Modern histological classifications especially designed for children are deemed necessary to accurately diagnose GBM.
authors.affiliation: Department of Neurosurgery, Hospital Infantil de México Federico Gómez, 06720 Mexico, D.F., Mexico.
authors.forename: Federico
authors.initials: F
authors.lastname: Sánchez-Herrera
authors.forename: Eduardo
authors.initials: E
authors.lastname: Castro-Sierra
authors.forename: Luis Felipe
authors.initials: LF
authors.lastname: Gordillo-Domínguez
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Vaca-Ruiz
authors.forename: Blanca
authors.initials: B
authors.lastname: Santana-Montero
authors.forename: Mario
authors.initials: M
authors.lastname: Perezpeña-Diazconti
authors.forename: Vicente
authors.initials: V
authors.lastname: González-Carranza
authors.forename: Samuel
authors.initials: S
authors.lastname: Torres-García
authors.forename: Fernando
authors.initials: F
authors.lastname: Chico-Ponce de León
mesh_terms: D000367:Age Factors; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006776:Hospitals, Pediatric; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008800:Mexico; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate