Status epilepticus in a pediatric patient with amantadine overdose.
A 2-year-old boy who ingested 0.8-1.5 g of amantadine developed status epilepticus. One hour later, the child presented with agitation, diaphoresis, and vomiting. He was admitted to the pediatric emergency department 2 hours later. Generalized seizures evolved to status epilepticus, with alternating generalized tonic-clonic and partial seizures, over a period of 7 hours. Other initial clinical signs were sinusal tachycardia and reactive bilateral mydriasis. All symptoms resolved within 20 hours, with a good recovery; the child was released from the hospital on day 3.
Claudet
Isabelle
I
Pediatric Emergency Department, Children's Hospital, Toulouse, France. claudet.i@chu-toulouse.fr
Maréchal
Céline
C
D000547:Amantadine / Q000506:poisoning*; D002675:Child, Preschool; D015259:Dopamine Agents / Q000506:poisoning*; D062787:Drug Overdose; D006801:Humans; D008297:Male; D015878:Mydriasis / Q000139:chemically induced; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced; D013226:Status Epilepticus / Q000139:chemically induced*; D013610:Tachycardia / Q000139:chemically induced
D015259:Dopamine Agents; D016194:Receptors, N-Methyl-D-Aspartate; D000547:Amantadine