Effects of synthetic monocyte chemotactic protein-1 fragment 65-76 on neointima formation after carotid artery balloon injury in rats.
The effects of the synthetic monocyte chemotactic protein-1 (MCP-1) peptide fragment 65-76 (peptide X) on the development of neointima after balloon injury to the carotid artery were studied. The agent was given i.m. at a dose of 33 microg/kg once daily for 28 days after balloon injury. Animals given peptide showed significant suppression of neointima growth 4 and 7 days after lesioning, as indicated by morphometric analysis of sections of lesioned arteries. On days 14 and 28, there were no significant differences in neointima formation in rats given and not given peptide. Peptide administration was not accompanied by any changes in C-reactive peptide concentrations, leukocyte counts, or the population composition of peripheral blood lymphocytes. Use of synthetic peptide X as an inhibitor of leukocyte migration during angioplasty may, along with traditional treatments, decrease the risk of restenosis.
Kukhtina
N B
NB
Federal State Cardiological Scientific-Industrial Complex Rosmedtekhnologii, 15a 3rd Cherepkovskaya Street, 121552, Moscow, Russia. kukhtina@cardio.ru
Bashtrykov
P P
PP
Bespalova
Zh D
ZhD
Sidorova
M V
MV
Aref'eva
T I
TI
Sokolov
V O
VO
Krasnikova
T L
TL
D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000378:metabolism* / Q000473:pathology; D020212:Carotid Artery Injuries / Q000097:blood / Q000188:drug therapy*; D018932:Chemokine CCL2 / Q000494:pharmacology*; D006083:Graft Occlusion, Vascular / Q000517:prevention & control; D007958:Leukocyte Count; D008297:Male; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017539:Tunica Intima / Q000378:metabolism*
C491766:Ccl2 protein, rat; D018932:Chemokine CCL2; D010455:Peptides; D002097:C-Reactive Protein