Prospective evaluation of quality of life after permanent prostate brachytherapy with I-125: importance of baseline symptoms and of prostate-V150.
OBJECTIVE
Detailed knowledge of quality of life (QoL) after permanent I-125 brachytherapy may aid in counselling patients with early-stage prostate cancer.


METHODS
Seventy-four consecutive patients with low-risk prostate cancer were asked to complete the EORTC QLQ-C30 questionnaire with the prostate-specific PR25 module before implant, four weeks and one year after implant (response rates 97%, 88% and 89%, respectively). Implant characteristics were correlated with QoL scores.


RESULTS
Global QoL was stable from pre-treatment to one year after implant and similar to age-adjusted scores of healthy controls. Significant changes versus baseline in QLQ-C30 domains were worsened social function at four weeks, increased constipation at four weeks and at one year and improved emotional function at one year. PR25 urinary symptoms were significantly increased at four weeks and, despite some improvement, at one year; bowel symptoms were slightly increased. Both types of symptoms were most strongly related with pre-treatment symptom scores. Prostate-V150 was the only implant parameter significantly associated with both urinary and bowel symptoms at four weeks and one year.


CONCLUSIONS
Limiting the high-dose subvolume in the prostate may be beneficial to reduce urinary and bowel symptoms but the major determinant of symptoms after I-125 implant is the baseline symptom level.
Vordermark
Dirk
D
Department of Radiation Oncology, University of Würzburg, Germany. vordermark_d@klinik.uni-wuerzburg.de
Noe
Michael
M
Markert
Klaus
K
Wulf
Jörn
J
Müller
Gerd
G
Bratengeier
Klaus
K
Beckmann
Gabriele
G
Baier
Fabian
F
Guckenberger
Matthias
M
Schiefelbein
Frank
F
Schön
Georg
G
Flentje
Michael
M
Baier
Kurt
K
D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000523:psychology* / Q000532:radiotherapy*; D011788:Quality of Life
D007457:Iodine Radioisotopes