Oscillating perceptions: the ups and downs of the CLOCK protein in the mouse circadian system.
A functional mouse CLOCK protein has long been thought to be essential for mammalian circadian clockwork function, based mainly on studies of mice bearing a dominant negative, antimorphic mutation in the Clock gene. However, new discoveries using recently developed Clock-null mutant mice have shaken up this view. In this review, I discuss how this recent work impacts and alters the previous view of the role of CLOCK in the mouse circadian clockwork.
Debruyne
Jason P
JP
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. debruyne@mail.med.upenn.edu
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000502:physiology; D001683:Biological Clocks / Q000235:genetics*; D056926:CLOCK Proteins; D002940:Circadian Rhythm / Q000235:genetics*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D051379:Mice / Q000235:genetics* / Q000502:physiology; D018345:Mice, Knockout; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics* / Q000502:physiology
D051792:Basic Helix-Loop-Helix Proteins; D056926:CLOCK Proteins; D009419:Nerve Tissue Proteins; D015534:Trans-Activators; C491259:Npas2 protein, mouse; C538943:CLOCK protein, human; C538944:Clock protein, mouse