title: A new strategy for the synthesis of optically pure beta-fluoroalkyl beta-amino acid derivatives.
abstract: The first general approach for the diastereoselective formation of a variety of optically pure anti-beta-fluoroalkyl beta-amino acid derivatives is described. The process relies on the stereocontrolled reaction, mediated by a remote sulfoxide, of fluorinated imines with sulfinylated benzyl carbanions, which are used as synthetic equivalents of chiral ester enolates.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia, E-46100 Burjassot, Spain.
authors.forename: Santos
authors.initials: S
authors.lastname: Fustero
authors.forename: Carlos
authors.initials: C
authors.lastname: del Pozo
authors.forename: Silvia
authors.initials: S
authors.lastname: Catalán
authors.forename: José
authors.initials: J
authors.lastname: Alemán
authors.forename: Alejandro
authors.initials: A
authors.lastname: Parra
authors.forename: Vanesa
authors.initials: V
authors.lastname: Marcos
authors.forename: José Luis García
authors.initials: JL
authors.lastname: Ruano
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013454:Sulfoxides / Q000737:chemistry
chemical_list: D000596:Amino Acids; D006845:Hydrocarbons, Fluorinated; D013454:Sulfoxides