Audiogenic epilepsy in young mice of different strains after neonatal semax treatment.
Neonatal (from day 2 to day 7 of life) injection of neuropeptide semax to mice of 5 inbred strains significantly reduced predisposition to audiogenic epilepsy in only one-month-old DBA/2J mice, which manifested in changes in the mean audiogenic sensitivity score and percentage of animals dead as a result of acoustic stimulation.
Boyarshinova
O S
OS
Laboratory of Behavioral Physiology and Genetics, Biological Faculty, M. V. Lomonosov Moscow University, Russia.
Perepelkina
O V
OV
Markina
N V
NV
Poletaeva
I I
II
D000161:Acoustic Stimulation; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000831:Animals, Newborn; D004198:Disease Susceptibility; D020195:Epilepsy, Reflex / Q000188:drug therapy* / Q000235:genetics / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010446:Peptide Fragments / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D018696:Neuroprotective Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone