The use of bioactive wound dressing, stimulating epithelial regeneration of IIIa-degree burn wounds.
Clinical and morphological comparison of wound healing after transplantation of living cultured allofibroblast on days 1-2 after the injury, collagen-1-based dressing with PDGF-BB, and traditional dressing with levomecol ointment showed that bioactive dressing accelerated wound epithelialization (5-7 days vs. 20-22 days with gauze dressing); the incidence of suppurative complications decreased, no crust formed, and epithelialization was not associated with the formation of a hypertrophic cicatrix. Biological dressing based on living cultured allofibroblasts and collagen-1 with PDGF-BB exhibited equal stimulatory effects on burn wound healing.
Ermolov
A S
AS
N. V. Sklifosovsky Institute of Urgent Care, Moscow, Russia.
Smirnov
S V
SV
Khvatov
V B
VB
Istranov
L P
LP
Koniushko
O I
OI
Kolokolchikova
E G
EG
Sychevsky
M V
MV
Bocharova
V S
VS
D000077214:Becaplermin; D001684:Biological Dressings; D002056:Burns / Q000473:pathology / Q000628:therapy; D017690:Cell Transplantation; D002478:Cells, Cultured; D004848:Epithelium / Q000473:pathology / Q000502:physiology; D005260:Female; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008297:Male; D010982:Platelet-Derived Growth Factor / Q000627:therapeutic use; D020574:Proto-Oncogene Proteins c-sis; D012038:Regeneration / Q000502:physiology*; D014945:Wound Healing
D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D000077214:Becaplermin