title: Antioxidant and endothelium-stabilizing effects of simvaglyzin on rabbits with experimental hypercholesterolemia.
abstract: Simvaglyzin, a complex compound of simvastatin and glycyrrhizic acid, administered to rabbits with experimental hypercholesterolemiain in doses equivalent to 66.6 and 40 microg/kg simvastatin exhibited antioxidant capacity (decreased the content of lipid peroxidation products in the blood by 27-41%) and endothelium-normalizing effect (decreased the level of von Willebrand factor and endothelin-1 by 26-58 and 21-29%, respectively, compared to 200 microg/kg simvastatin, p<0.05).
authors.affiliation: N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: Yu I
authors.initials: YI
authors.lastname: Ragino
authors.forename: V A
authors.initials: VA
authors.lastname: Vavilin
authors.forename: N F
authors.initials: NF
authors.lastname: Salakhutdinov
authors.forename: S I
authors.initials: SI
authors.lastname: Makarova
authors.forename: E M
authors.initials: EM
authors.lastname: Stakhneva
authors.forename: O G
authors.initials: OG
authors.lastname: Safronova
authors.forename: V V
authors.initials: VV
authors.lastname: Lyakhovich
authors.forename: Yu P
authors.initials: YP
authors.lastname: Nikitin
authors.forename: G A
authors.initials: GA
authors.lastname: Tolstikov
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004032:Diet; D019332:Endothelin-1 / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects*; D005470:Fluorometry; D019695:Glycyrrhizic Acid / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D009609:Nitrous Oxide / Q000378:metabolism; D011817:Rabbits; D019821:Simvastatin / Q000627:therapeutic use*; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D000924:Anticholesteremic Agents; D000975:Antioxidants; D019332:Endothelin-1; C531004:simvaglyzin; D014841:von Willebrand Factor; D019695:Glycyrrhizic Acid; D002784:Cholesterol; D019821:Simvastatin; D043303:Aryldialkylphosphatase; D009609:Nitrous Oxide