title: Causal relationships between esophageal squamous cell carcinoma and nephrotic syndrome.
abstract: We present a case of membranous nephropathy (MN) associated with esophageal squamous cell carcinoma (ESCC) with a high serum level of squamous cell carcinoma antigen (SCC). ESCC reached complete response (CR) for radiotherapy, with a partial remission of the proteinuria and decreased serum SCC levels. Six months after radiotherapy, the ESCC recurred, and the patient was treated with endoscopic mucosal resection (EMR), achieving a pathologic CR and disappearance of proteinuria and normalized serum SCC levels. The correlation of proteinuria and the serum level of SCC indicates that SCC could be a pathogenic antigen, responsible for the pathogenesis of MN in this patient.
authors.affiliation: The Second Department of Internal Medicine, Showa University School of Medicine, Tokyo.
authors.forename: Takashi
authors.initials: T
authors.lastname: Muramoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kaneko
authors.forename: Aki
authors.initials: A
authors.lastname: Kuroki
authors.forename: Kazuo
authors.initials: K
authors.lastname: Konishi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ito
authors.forename: Atsushi
authors.initials: A
authors.lastname: Katagiri
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Kubota
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ohtsu
authors.forename: Michio
authors.initials: M
authors.lastname: Imawari
mesh_terms: D000951:Antigens, Neoplasm / Q000097:blood; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D004938:Esophageal Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D015843:Serpins / Q000097:blood
chemical_list: D000951:Antigens, Neoplasm; D015843:Serpins; C051072:squamous cell carcinoma-related antigen