title: Role of potassium and chlorine channels in the regulation of thymocyte volume in rats.
abstract: Regulatory decrease in thymocyte volume under conditions of osmotic stress was abolished by potassium and chlorine channel blockers. Osmotic stress-activated chlorine channels belong to 2 pharmacological types. The maxi-anion channel is sensitive to Gd(3+). The volume-sensitive outwardly rectifying chlorine channel is inhibited with glybenclamide and phloretin.
authors.affiliation: Laboratory of Molecular Physiology, Institute of Physiology and Biophysics, Uzbekistan Academy of Sciences, Uzbekistan. ravshansabirov@yahoo.com
authors.forename: R S
authors.initials: RS
authors.lastname: Kurbannazarova
authors.forename: B A
authors.initials: BA
authors.lastname: Tashmukhamedov
authors.forename: R Z
authors.initials: RZ
authors.lastname: Sabirov
mesh_terms: D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005682:Gadolinium / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D066298:In Vitro Techniques; D017136:Ion Transport / Q000187:drug effects; D009997:Osmotic Pressure; D010693:Phloretin / Q000494:pharmacology; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*
chemical_list: D018118:Chloride Channels; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D005682:Gadolinium; C038958:gadolinium chloride; D010693:Phloretin; D005905:Glyburide