title: Language processing deficits in sickle cell disease in young school-age children.
abstract: Verbal IQ deficits are frequently reported for school-age children with sickle cell disease (SCD), yet the profile of language abilities in SCD is unclear. We examined semantic, syntactic, and phonological processing in five-to-seven-year-olds at high neurologic risk based on SCD subtype (N = 33), at low neurologic risk with SCD (N = 21), and without SCD (N = 54). Low-risk SCD did not show language processing deficits. High-risk SCD showed deficits in all three language domains. Language processing deficits in SCD at the start of middle childhood are related to neurologic risks and include language skills beyond vocabulary.
authors.affiliation: Departments of Psychology and Pediatrics, University of South Carolina, Columbia, 29205, USA. schatz@sc.edu
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Schatz
authors.forename: Eve S
authors.initials: ES
authors.lastname: Puffer
authors.forename: Carmen
authors.initials: C
authors.lastname: Sanchez
authors.forename: Melita
authors.initials: M
authors.lastname: Stancil
authors.forename: Carla W
authors.initials: CW
authors.lastname: Roberts
mesh_terms: D000755:Anemia, Sickle Cell / Q000150:complications* / Q000523:psychology*; D017028:Caregivers / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000209:etiology*; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010287:Parent-Child Relations; D013223:Statistics as Topic; D011795:Surveys and Questionnaires