Genetic mechanisms underlying the pathogenesis of tropical calcific pancreatitis.
Chronic pancreatitis is known to be a heterogeneous disease with varied etiologies. Tropical calcific pancreatitis (TCP) is a severe form of chronic pancreatitis unique to developing countries. With growing evidence of genetic factors contributing to the pathogenesis of TCP, this review is aimed at compiling the available information in this field. We also propose a two hit model to explain the sequence of events in the pathogenesis of TCP.
Mahurkar
Swapna
S
Asian Institute of Gastroenterology, Somajiguda, Hyderabad, Andhra Pradesh, India.
Reddy
D Nageshwar
DN
Rao
G Venkat
GV
Chandak
Giriraj Ratan
GR
D002114:Calcinosis / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D009154:Mutation; D050500:Pancreatitis, Chronic / Q000209:etiology / Q000235:genetics* / Q000473:pathology*; D014329:Tropical Climate; D014357:Trypsin; D014359:Trypsin Inhibitor, Kazal Pancreatic; D014362:Trypsinogen / Q000235:genetics / Q000378:metabolism
D002352:Carrier Proteins; C486642:SPINK1 protein, human; D014359:Trypsin Inhibitor, Kazal Pancreatic; D014362:Trypsinogen; C489303:PRSS1 protein, human; D014357:Trypsin