title: Metabolic syndrome after kidney transplantation.
abstract: Metabolic syndrome (MS) can be linked to the progression of chronic renal transplant dysfunction (CRTD). Hyperfiltration in transplanted patients is a further risk factor for MS and for the progression of CRTD. Many studies show in kidney-transplanted subjects a prevalence of MS at 60% after 6 years posttransplantation. We studied 182 patients (126 men and 56 women) with functioning renal transplant in Messina and Rovigo Renal Units. In our patients we saw at 6 years postkidney transplant in men a prevalence of MS at 20% (NCEPATPIII criteria) or 30% (Rovigo-Messina more strict criteria), and women at 6 years posttransplantation a prevalence of MS at 25% (NCEPATPIII criteria) or 50% (Rovigo-Messina criteria). In our patients, the period of graft function was over 15 years. This result is due to continued follow-up of metabolic parameters and to moderate protein (0.8-0.9 g/kg/day), low lipid, and low caloric intake. These strategies permit the avoidance of hyperfiltration, the reduction of hyperlipidemia and obesity. Special attention is due to women 50-65 years old. In these patients the prevalence of metabolic syndrome 6 years posttransplant is very high (60%). Postmenopausal syndrome is an additional risk factor for MS, atherosclerosis, and the progression of CRTD.
authors.affiliation: Cattedra di Nefrologia, Università di Messina, SOC di Nefrologia-Nutrizione Clinica ULSS 18 Rovigo, Italy.
authors.forename: Guido
authors.initials: G
authors.lastname: Bellinghieri
authors.forename: Annamaria
authors.initials: A
authors.lastname: Bernardi
authors.forename: Michele
authors.initials: M
authors.lastname: Piva
authors.forename: Tecla
authors.initials: T
authors.lastname: Pati
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Stoppa
authors.forename: Paolo
authors.initials: P
authors.lastname: Scaramuzzo
authors.forename: Odino
authors.initials: O
authors.lastname: Garizzo
authors.forename: Domenico
authors.initials: D
authors.lastname: Santoro
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Savica
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bucciante
mesh_terms: D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008593:Menopause; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology*; D011183:Postoperative Complications; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors