title: [The effect of environmental and genetic factors in the pathogenesis of periodontitis].
abstract: BACKGROUND
  The pathogenesis ofperiodontitis has not been completely defined, therefore the study was aimed at evaluating combined effects of environmental factors as well as interleukin-1beta (IL-1beta) and FcgammaRIIa genotypes on the risk of periodontal disease.
  
  
  METHODS
  The study was carried out on 52 patients diagnosed with periodontitis (P), 20 suffering from aggressive periodontitis (AgP), 32 with chronic periodontitis (CP) as well as 52 subjects with healthy periodontium (HP). Interleukin-1beta genotype was evaluated using PCR-RFLP, whereas FcdeltaRIIa polymorphism with the application of PCR-ASA method.
  
  
  RESULTS
  The frequency of IL-1beta 1/1, 1/2, 2/2 genotype was as follows: AgP patients--75%, 25%, 0%, CP: 65.6%, 34.4%, 0%, and P: 69.2%, 30.7%, 0%, respectively, and did not differ significantly from HP. Alike, no significant differences were found in FcgammaRIIa genotype distribution. H/H, R/H, R/R genotypes were revealed in 40.0%, 35.0%, 25.0% for AgP, 43.8%, 40.6%, 15.6% in CP patients, 42.3%, 38.5%, 19.2% for P subjects as well as 36.5%, 48.1%, 15.4% in HP subjects. Multivariate analysis revealed a significant association between AgP and age, smoking and API > 50%. As for CP significant association was found solely for API > 50%.
  
  
  CONCLUSIONS
  IL-1B(+3954) and FcgammaRIIa (CD32) gene polymorphisms are not associated with an increased risk of AgP and CP.
authors.affiliation: Zakład Periodontologii Katedry Stomatologii Zachowawczej i Periodontologii Pomorskiej Akademii Medycznej w Szczecinie al. Powstańców Wlkp. 72, 70-111 Szczecin.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Droździk
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D015984:Causality; D015897:Comorbidity; D005260:Female; D005787:Gene Frequency; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010518:Periodontitis / Q000453:epidemiology* / Q000235:genetics*; D011044:Poland / Q000453:epidemiology; D011110:Polymorphism, Genetic; D017452:Receptors, IgG / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology*
chemical_list: C080568:Fc gamma receptor IIA; D053583:Interleukin-1beta; D017452:Receptors, IgG