Optimizing unrelated donor cord blood transplantation.
In contrast to the very high transplant-related mortality (TRM) associated with the early experience of cord blood (CB) transplantation (CBT), recent transplant series have been associated with comparable survival to that of human leucocyte antigen (HLA)-matched unrelated donor transplantation in children with similarly promising results in adults. Consequently, the use of CB as an alternative stem cell source and the global inventory of units in public banks are rapidly increasing although challenges remain. This review will address efforts to optimize CBT from 3 different perspectives: that of the transplant center, the CBT registry, and the CB bank.
Barker
Juliet N
JN
Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Rocha
Vanderson
V
Scaradavou
Andromachi
A
D001771:Blood Banks / Q000592:standards; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods / Q000592:standards*; D005312:Fetal Blood / Q000166:cytology; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D012042:Registries; D014019:Tissue Donors; D000094902:Blood Banking / Q000379:methods