Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.
We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions. Therefore, a comparison of phosphovariants between individuals or between species can give clues about phenotypic differences. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.
Ryu
Gil-Mi
GM
Center for Genome Science, 5 Nokbun-Dong, Eunpyung-Ku, Seoul, 122-701, Korea.
Song
Pamela
P
Kim
Kyu-Won
KW
Oh
Kyung-Soo
KS
Park
Keun-Joon
KJ
Kim
Jong Hun
JH
D014644:Genetic Variation; D023281:Genomics / Q000379:methods; D010750:Phosphoproteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D020539:Sequence Analysis, Protein; D012984:Software
D010750:Phosphoproteins; D011494:Protein Kinases