[Interleukin-1beta gene polymorphism as a predictor of eradication treatment efficacy in gastric and duodenal ulcer associated with Helicobacter pylori].
The results of recent research that IL gene polymorphism powerfully affects the course and the resolve of HP infection and finally impacts its treatment. The present article into the problem of IL polymorphism impact on HP eradication therapy efficiency in ulcer disease. The presence of proinflammatory allele positively influences eradication therapy, which can be used for determining the risk groups and individualized eradication therapy.
Oganesian
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D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use; D017291:Clarithromycin / Q000008:administration & dosage / Q000627:therapeutic use; D016145:Endoscopy, Digestive System; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D053583:Interleukin-1beta; D000658:Amoxicillin; D017291:Clarithromycin; D009853:Omeprazole