[The influence of a tibolone therapy on endometrium in postmenopausal women].
OBJECTIVE
Assessment of the frequency of vaginal bleeding and morphologic changes of endometrium in postmenopausal women treated with tibolone.


METHODS
26 patients, aged from 50 to 70 (mean 59.7+/-6.7) years, without contraindications to hormonal replacement therapy.


METHODS
The therapy with a tibolone in a daily dose of 2.5 mg during the course of 1 year. The assessment of endometrium was obtained by means of transvaginal ultrasound examination (USG TV) and curratage and/or biopsy with Pipelle probe.


RESULTS
during the therapy with tibolone, vaginal bleeding was noted in case of 3 (11.5%) postmenopausal women. The thickness of endometrium measured by USG TV was mean 4.6+/-2.3mm and did not change enough to be considered statistically significant during the therapy. Endometrial morphology assessed by curratage and/or biopsy showed atrophic endometrium in 20 patients, polyposis endometrium in 1 case or no samples.


CONCLUSIONS
Tibolone therapy leads to low rates of vaginal bleeding and atrophic changes of the endometrium. Tibolone is a safe and effective alternative to hormonal therapy in postmenopausal women.
Szlendak-Sauer
Katarzyna
K
Klinika Endokrynologii Ginekologicznej Warszawski Uniwersytet Medyczny. kasiasauer@gmail.com
Wierzba
Waldemar
W
Radowicki
Stanisław
S
D000368:Aged; D045930:Anabolic Agents / Q000008:administration & dosage*; D004717:Endometrium / Q000000981:diagnostic imaging / Q000187:drug effects*; D020847:Estrogen Receptor Modulators / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009652:Norpregnenes / Q000008:administration & dosage*; D011044:Poland; D017698:Postmenopause / Q000187:drug effects*; D016896:Treatment Outcome; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000139:chemically induced; D014621:Vagina / Q000187:drug effects
D045930:Anabolic Agents; D020847:Estrogen Receptor Modulators; D009652:Norpregnenes; C027385:tibolone