The intracellular localization of ID2 expression has a predictive value in non small cell lung cancer.
BACKGROUND
ID2 is a member of a subclass of transcription regulators belonging to the general bHLH (basic-helix-loop-helix) family of transcription factors. In normal cells, ID2 is responsible for regulating the balance between proliferation and differentiation. More recent studies have demonstrated that ID2 is involved in tumor progression in several cancer types such as prostate or breast.


RESULTS
In this work, we investigated, for the first time, the relationship between the expression of ID2 in non-small cell lung cancer (NSCLC) patients and the clinicopathological features and prognosis of these patients. Immunohistochemistry was performed on tissue microarrays, which included 62 NSCLC tumors. In malignant tissues, ID2 expression has been detected in both the nuclear and cytoplasmic compartments, but we have demonstrated that only nuclear expression of ID2 is inversely correlated with the differentiation grade of the tumor (p = 0.007). Interestingly, among patients with poorly differentiated tumors, high nuclear expression of ID2 was an independent and unfavorable prognostic factor for survival (p = 0.036).


CONCLUSIONS
These results suggest that ID2 could be involved in tumor dedifferentiation processes of NSCLC, and could be used as prognostic marker for patients with poorly differentiated tumors.
Rollin
Jérôme
J
CEA, DSV, IRCM, Laboratoire d'Exploration Fonctionnelle des Génomes, Evry, France.
Bléchet
Claire
C
Régina
Sandra
S
Tenenhaus
Arthur
A
Guyétant
Serge
S
Gidrol
Xavier
X
D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D007150:Immunohistochemistry; D051797:Inhibitor of Differentiation Protein 2 / Q000032:analysis* / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D011446:Prospective Studies; D040081:Protein Array Analysis; D014407:Tumor Cells, Cultured
C497450:ID2 protein, human; D051797:Inhibitor of Differentiation Protein 2