Hepatoprotective properties of fractions from meadowsweet extract during experimental toxic hepatitis.
Fractions of the extract from meadowsweet aerial parts in 70% ethanol exhibited hepatoprotective properties during CCl4-induced toxic hepatitis. This extract produced a normalizing effect on activity of enzymes, markers of cytolysis, lipid peroxidation, and antioxidant defense system in liver cells. Fractionation of the extract was accompanied by dissociation of the effect. These changes reflect specific action of a complex of bioactive substances. The ethyl acetate and chloroform fractions from this extract were most potent. The effectiveness of these fractions by several parameters surpassed that of Carsil.
Shilova
I V
IV
Department of Biochemistry and Spectral Analysis, Central Research Laboratory, Siberian State Medical University, Tomsk, Russia. licvostok@mail.tomsknet.ru
Zhavoronok
T V
TV
Souslov
N I
NI
Novozheeva
T P
TP
Mustafin
R N
RN
Losseva
A M
AM
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy*; D031984:Filipendula / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
D015415:Biomarkers; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D002251:Carbon Tetrachloride