title: SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation.
abstract: SulfoSYS (Sulfolobus Systems Biology) focuses on the study of the CCM (central carbohydrate metabolism) of Sulfolobus solfataricus and its regulation under temperature variation at the systems level. In Archaea, carbohydrates are metabolized by modifications of the classical pathways known from Bacteria or Eukarya, e.g. the unusual branched ED (Entner-Doudoroff) pathway, which is utilized for glucose degradation in S. solfataricus. This archaeal model organism of choice is a thermoacidophilic crenarchaeon that optimally grows at 80 degrees C (60-92 degrees C) and pH 2-4. In general, life at high temperature requires very efficient adaptation to temperature changes, which is most difficult to deal with for organisms, and it is unclear how biological networks can withstand and respond to such changes. This integrative project combines genomic, transcriptomic, proteomic and metabolomic, as well as kinetic and biochemical information. The final goal of SulfoSYS is the construction of a silicon cell model for this part of the living cell that will enable computation of the CCM network. In the present paper, we report on one of the first archaeal systems biology projects.
authors.affiliation: Molecular Biology of Archaea, Max-Planck Institute for Terrestrial Microbiology, Karl-von-Frisch-Strasse, 35043 Marburg, Germany.
authors.forename: Sonja-Verena
authors.initials: SV
authors.lastname: Albers
authors.forename: Nils-Kåre
authors.initials: NK
authors.lastname: Birkeland
authors.forename: Arnold J M
authors.initials: AJ
authors.lastname: Driessen
authors.forename: Susanne
authors.initials: S
authors.lastname: Gertig
authors.forename: Patrick
authors.initials: P
authors.lastname: Haferkamp
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Klenk
authors.forename: Theresa
authors.initials: T
authors.lastname: Kouril
authors.forename: Andrea
authors.initials: A
authors.lastname: Manica
authors.forename: Trong K
authors.initials: TK
authors.lastname: Pham
authors.forename: Peter
authors.initials: P
authors.lastname: Ruoff
authors.forename: Christa
authors.initials: C
authors.lastname: Schleper
authors.forename: Dietmar
authors.initials: D
authors.lastname: Schomburg
authors.forename: Kieran J
authors.initials: KJ
authors.lastname: Sharkey
authors.forename: Bettina
authors.initials: B
authors.lastname: Siebers
authors.forename: Pawel
authors.initials: P
authors.lastname: Sierocinski
authors.forename: Ralf
authors.initials: R
authors.lastname: Steuer
authors.forename: John
authors.initials: J
authors.lastname: van der Oost
authors.forename: Hans V
authors.initials: HV
authors.lastname: Westerhoff
authors.forename: Patricia
authors.initials: P
authors.lastname: Wieloch
authors.forename: Phillip C
authors.initials: PC
authors.lastname: Wright
authors.forename: Melanie
authors.initials: M
authors.lastname: Zaparty
mesh_terms: D050260:Carbohydrate Metabolism; D053263:Gene Regulatory Networks; D008954:Models, Biological; D048229:Sulfolobus solfataricus / Q000378:metabolism*; D049490:Systems Biology; D013696:Temperature