title: Provoked ictal SPECT in temporal and extratemporal drug-resistant epileptic patients: comparison of Statistical Parametric Mapping and qualitative analysis.
abstract: OBJECTIVE
  To compare Statistical Parametric Mapping (SPM) with qualitative analysis of provoked ictal SPECT, in terms of both diagnostic yield and efficacy in identifying the epileptogenic zone of temporal and extratemporal epileptic patients.
  
  
  METHODS
  We included in the study 27 drug-resistant epileptic patients submitted to provoked ictal SPECT and for whom both SPM and qualitative analysis were obtained. A comparison between visual SPECT analysis and SPM results was performed in terms of lateralization and localization of the ictal hyperperfusion areas. Then, hyperperfusion areas were compared to epileptogenic zones to assess whether they co-localized or not.
  
  
  RESULTS
  In twenty patients, a co-localization was found between hyperperfusion areas detected by both qualitative and SPM analysis of provoked ictal SPECT and epileptogenic zones. A concordance between SPM and qualitative analysis in all but two patients was obtained. These findings were observed for both temporal and extratemporal epilepsies.
  
  
  CONCLUSIONS
  The co-localization between provoked ictal SPECT hyperperfusion areas and epileptogenic zones found in most patients supports the usefulness of this technique in integrating data provided by neuroimaging and electroclinical correlations to correctly define epileptogenic zone. Moreover, this preliminary work suggests that SPM as entirely objective methodology is feasible and can be accurate also after provoked ictal SPECT.
authors.affiliation: Pediatric Neurology, Children's Hospital A.Meyer, Viale Pieraccini, 24, 50139 Florence, Italy. c.barba@meyer.it
authors.forename: C
authors.initials: C
authors.lastname: Barba
authors.forename: D
authors.initials: D
authors.lastname: Di Giuda
authors.forename: F
authors.initials: F
authors.lastname: Fuggetta
authors.forename: G
authors.initials: G
authors.lastname: Colicchio
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D055815:Young Adult