title: 120-day comparative analysis of adhesion grade and quantity, mesh contraction, and tissue response to a novel omega-3 fatty acid bioabsorbable barrier macroporous mesh after intraperitoneal placement.
abstract: OBJECTIVE
  This study aimed to evaluate adhesion formation, mesh contraction, and tissue response to an omega-3 fatty acid barrier-coated lightweight polypropylene mesh (C-Qur) after intra-abdominal placement, and compare these properties to those of other commercially available meshes.
  
  
  METHODS
  After randomization, 3 x 3 cm pieces of Atrium C-Qur, Mesh ProLite Ultra, Composix, Parietex, Proceed, Sepramesh, and DualMesh were sewn to the intact peritoneum on either side of a midline incision in 41 New Zealand white rabbits. Necropsy was performed at 120 days, and explants were evaluated for adhesion grade, adhesion amount, and mesh contraction. Histologic evaluation included extent of capsule formation, abdominal wall tissue ingrowth, degrees of inflammation and vascularization of the surrounding tissue, and the presence of mesothelialization. Results. There were no significant differences between the C-Qur mesh and the commercially available meshes tested with regard to adhesion grade or amount, although percentage adhesion coverage for the C-Qur mesh was much less than for Composix and Proceed. The C-Qur mesh contracted less than all meshes, significantly less (P < .05) than DualMesh or Proceed. DualMesh exhibited the greatest amount of capsule formation and inflammation on its parietal side as compared with the other meshes.
  
  
  CONCLUSIONS
  Placing lightweight polypropylene mesh with an omega-3 fatty acid barrier coating intraperitoneally results in more favorable adhesion characteristics compared with Composix and Proceed meshes at 120-day explantation after intraperitoneal placement. The minimal amount of contraction and favorable tissue response in comparison to other commercially available meshes makes C-Qur mesh a practical alternative for laparoscopic and open ventral hernia repair.
authors.affiliation: Department of Surgery and Institute for Minimally Invasive Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Pierce
authors.forename: Juan M
authors.initials: JM
authors.lastname: Perrone
authors.forename: Abdelrahman
authors.initials: A
authors.lastname: Nimeri
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Sexton
authors.forename: Julie
authors.initials: J
authors.lastname: Walcutt
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Frisella
authors.forename: Brent D
authors.initials: BD
authors.lastname: Matthews
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D010537:Peritoneum / Q000601:surgery; D011126:Polypropylenes; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D013526:Surgical Mesh; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D020099:Coated Materials, Biocompatible; D015525:Fatty Acids, Omega-3; D011126:Polypropylenes