Simpson's paradox in a synthetic microbial system.
The maintenance of "public" or "common good" producers is a major question in the evolution of cooperation. Because nonproducers benefit from the shared resource without bearing its cost of production, they may proliferate faster than producers. We established a synthetic microbial system consisting of two Escherichia coli strains of common-good producers and nonproducers. Depending on the population structure, which was varied by forming groups with different initial compositions, an apparently paradoxical situation could be attained in which nonproducers grew faster within each group, yet producers increased overall. We show that a simple way to generate the variance required for this effect is through stochastic fluctuations via population bottlenecks. The synthetic approach described here thus provides a way to study generic mechanisms of natural selection.
Chuang
John S
JS
Center for Studies in Physics and Biology and Laboratory of Living Matter, Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. chuangj@rockefeller.edu
Rivoire
Olivier
O
Leibler
Stanislas
S
D015107:4-Butyrolactone / Q000031:analogs & derivatives / Q000378:metabolism; D000220:Adaptation, Biological; D002701:Chloramphenicol / Q000494:pharmacology; D002702:Chloramphenicol Resistance / Q000235:genetics; D015169:Colony Count, Microbial; D003470:Culture Media; D017077:Culture Media, Conditioned; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism; D008025:Ligases / Q000235:genetics / Q000378:metabolism; D055641:Mathematical Concepts; D053038:Quorum Sensing; D012641:Selection, Genetic; D013269:Stochastic Processes; D013598:Systems Theory; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D003470:Culture Media; D017077:Culture Media, Conditioned; D029968:Escherichia coli Proteins; D014157:Transcription Factors; C088386:homoserine lactone; D002701:Chloramphenicol; D008025:Ligases; C096955:RHLI protein, Pseudomonas aeruginosa; D015107:4-Butyrolactone