title: Applications of multicomponent reactions to the synthesis of diverse heterocyclic scaffolds.
abstract: The sequencing of multicomponent reactions (MCRs) and subsequent cyclization reactions is a powerful stratagem for the rapid synthesis of diverse heterocyclic scaffolds. The optimal MCR is sufficiently flexible that it can be employed to generate adducts bearing a variety of functional groups that may then be selectively paired to enable different cyclization manifolds, thereby leading to a diverse collection of products. The growing interest in diversity-oriented synthesis has led to increased attention to this paradigm for library synthesis, which has inspired many advances in the design and implementation of MCRs for the construction of diverse heterocyclic scaffolds.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station A5300, Austin TX 78712, USA.
authors.forename: James D
authors.initials: JD
authors.lastname: Sunderhaus
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D001688:Biological Products; D006571:Heterocyclic Compounds; C520957:beta-ketoamide