High concentrations of manganese in Mueller-Hinton agar increase MICs of tigecycline determined by Etest.
MICs of tigecycline determined by Etest were 4 to 12 times (three ATCC strains) and 2 to 8 times (50 clinical isolates) higher in Mueller-Hinton agar from Merck than in Mueller-Hinton agar from either Oxoid or Difco. This was related to a much higher concentration of manganese in the medium from Merck.
Fernández-Mazarrasa
Carlos
C
Service of Microbiology, Hospital Universitario Marqués de Valdecilla, Santander, Spain.
Mazarrasa
Olav
O
Calvo
Jorge
J
del Arco
Asunción
A
Martínez-Martínez
Luis
L
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001431:Bacteriological Techniques / Q000592:standards; D003470:Culture Media / Q000737:chemistry*; D006801:Humans; D008345:Manganese / Q000032:analysis*; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline
D000900:Anti-Bacterial Agents; D003470:Culture Media; D008345:Manganese; D000078304:Tigecycline; D008911:Minocycline