title: Bioactive constituents from Chinese natural medicines. XXXIII. Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages.
abstract: The methanolic extract from the seeds of Psoralea corylifolia was found to inhibit production of nitric oxide (NO) in lipopolysaccharide-activated mouse peritoneal macrophages. Among the isolated compounds, bavachinin (IC(50)=26 microM), isobavachalcone (17 microM), neobavaisoflavone (ca. 29 microM), corylifol A (ca. 21 microM), and psoralidin (ca. 23 microM) significantly inhibited the accumulation of nitrite (NO(2)(-)) as a marker of production of NO. Bakuchiol, which is mainly contained in the extract, also showed weak activity at 10 microM, but cytotoxic effects were observed more than 30 microM.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Sachie
authors.initials: S
authors.lastname: Kiyohara
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Shin
authors.initials: S
authors.lastname: Ando
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D012639:Seeds / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D009569:Nitric Oxide