On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation and Hodgkin lymphoma.
This mini-review is focused on the enzyme 15-lipoxygenase-1 (15-LO-1) and eoxins in airway inflammatory diseases and Hodgkin lymphoma. Several studies have demonstrated increased expression and activity of 15-LO-1 in the respiratory tissue from asthma patients , indicating a pathophysiological role of this enzyme in airway inflammation. Eoxins were recently identified as pro-inflammatory metabolites of arachidonic acid, formed through the 15-LO-1 pathway, in human eosinophils, mast cells, airway epithelial cells and Hodgkin lymphoma. Mice deficient of 12/15-LO, the ortholog to human 15-LO-1, had an attenuated allergic airway inflammation compared to wild type controls, also indicating a pathophysiological role of this enzyme in respiratory inflammation. The putative therapeutic implications of 15-LO-1 inhibitors in the treatment of asthma, chronic obstructive pulmonary disorder and Hodgkin lymphoma are discussed.
Claesson
Hans-Erik
HE
Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm and Orexo AB, Uppsala, Sweden. hans-erik.claesson@ki.se
D000818:Animals; D001092:Arachidonate 12-Lipoxygenase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D001093:Arachidonate 15-Lipoxygenase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D001249:Asthma / Q000201:enzymology / Q000378:metabolism*; D004804:Eosinophils / Q000378:metabolism; D006689:Hodgkin Disease / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D017998:Leukotriene D4 / Q000031:analogs & derivatives* / Q000378:metabolism; D015289:Leukotrienes / Q000378:metabolism*; D008168:Lung / Q000201:enzymology; D051379:Mice; D009928:Organ Specificity; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology / Q000378:metabolism*; D016539:Reed-Sternberg Cells / Q000201:enzymology / Q000473:pathology
C475064:12-15-lipoxygenase; D015289:Leukotrienes; D017998:Leukotriene D4; D001092:Arachidonate 12-Lipoxygenase; D001093:Arachidonate 15-Lipoxygenase