title: Metabolic syndrome and cardiometabolic risk: an update.
abstract: Several lines of evidence show that metabolic syndrome represents an important therapeutic challenge for the forthcoming years. This is because of the epidemic burden of this multifaceted disease, the adverse impact on cardiovascular risk, as well as the problems posed in its management. This paper will provide an up-to-date report on metabolic syndrome and cardiometabolic risk, focusing in particular on the epidemiological profile of the disease, the impact on risk profile and target organ damage as well as some of the main pathophysiological features of the condition. The general therapeutic recommendations, provided by the 2007 European Society of Hypertension/European Society of Cardiology Guidelines, will be briefly discussed.
authors.affiliation: Clinica Medica, Dipartimento di Medicina Clinica, Prevenzione e Biotecnologie Sanitarie, Universita Milano-Bicocca, Ospedale San Gerardo dei Tintori, Monza (Milan), Italy. guido.grassi@unimib.it
authors.forename: Guido
authors.initials: G
authors.lastname: Grassi
authors.forename: Gino
authors.initials: G
authors.lastname: Seravalle
authors.forename: Fosca
authors.initials: F
authors.lastname: Quarti-Trevano
authors.forename: Raffaella
authors.initials: R
authors.lastname: Dell'Oro
authors.forename: Michele
authors.initials: M
authors.lastname: Bombelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Mancia
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015331:Cohort Studies; D000075202:Contraindications; D018450:Disease Progression; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000517:prevention & control; D007328:Insulin / Q000502:physiology; D020738:Leptin / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000188:drug therapy / Q000453:epidemiology* / Q000503:physiopathology; D008875:Middle Aged; D017410:Practice Guidelines as Topic; D015995:Prevalence; D012307:Risk Factors; D013564:Sympathetic Nervous System / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D007328:Insulin; D020738:Leptin