title: Function of mitochondrial Stat3 in cellular respiration.
abstract: Cytokines such as interleukin-6 induce tyrosine and serine phosphorylation of Stat3 that results in activation of Stat3-responsive genes. We provide evidence that Stat3 is present in the mitochondria of cultured cells and primary tissues, including the liver and heart. In Stat3(-/-) cells, the activities of complexes I and II of the electron transport chain (ETC) were significantly decreased. We identified Stat3 mutants that selectively restored the protein's function as a transcription factor or its functions within the ETC. In mice that do not express Stat3 in the heart, there were also selective defects in the activities of complexes I and II of the ETC. These data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
authors.affiliation: Department of Biochemistry and Molecular Biology and Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.
authors.forename: Joanna
authors.initials: J
authors.lastname: Wegrzyn
authors.forename: Ramesh
authors.initials: R
authors.lastname: Potla
authors.forename: Yong-Joon
authors.initials: YJ
authors.lastname: Chwae
authors.forename: Naresh B V
authors.initials: NB
authors.lastname: Sepuri
authors.forename: Qifang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Thomas
authors.initials: T
authors.lastname: Koeck
authors.forename: Marta
authors.initials: M
authors.lastname: Derecka
authors.forename: Karol
authors.initials: K
authors.lastname: Szczepanek
authors.forename: Magdalena
authors.initials: M
authors.lastname: Szelag
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Gornicka
authors.forename: Akira
authors.initials: A
authors.lastname: Moh
authors.forename: Shadi
authors.initials: S
authors.lastname: Moghaddas
authors.forename: Qun
authors.initials: Q
authors.lastname: Chen
authors.forename: Santha
authors.initials: S
authors.lastname: Bobbili
authors.forename: Joanna
authors.initials: J
authors.lastname: Cichy
authors.forename: Jozef
authors.initials: J
authors.lastname: Dulak
authors.forename: Darren P
authors.initials: DP
authors.lastname: Baker
authors.forename: Alan
authors.initials: A
authors.lastname: Wolfman
authors.forename: Dennis
authors.initials: D
authors.lastname: Stuehr
authors.forename: Medhat O
authors.initials: MO
authors.lastname: Hassan
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Fu
authors.forename: Narayan
authors.initials: N
authors.lastname: Avadhani
authors.forename: Jennifer I
authors.initials: JI
authors.lastname: Drake
authors.forename: Paul
authors.initials: P
authors.lastname: Fawcett
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Lesnefsky
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Larner
mesh_terms: D000818:Animals; D019069:Cell Respiration; D002478:Cells, Cultured; D042967:Electron Transport Complex I / Q000378:metabolism; D042963:Electron Transport Complex II / Q000378:metabolism; D006706:Homeostasis; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D010085:Oxidative Phosphorylation; D010766:Phosphorylation; D054448:Precursor Cells, B-Lymphoid / Q000378:metabolism; D050796:STAT3 Transcription Factor / Q000737:chemistry / Q000378:metabolism*; D012694:Serine / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D012694:Serine; D042963:Electron Transport Complex II; D009247:NADH, NADPH Oxidoreductases; C486684:Grim19 protein, mouse; D042967:Electron Transport Complex I