Function of Nod-like receptors in microbial recognition and host defense.
Nucleotide oligomerization domain (NOD)-like receptors (NLRs) are a specialized group of intracellular proteins that play a critical role in the regulation of the host innate immune response. NLRs act as scaffolding proteins that assemble signaling platforms that trigger nuclear factor-kappaB and mitogen-activated protein kinase signaling pathways and control the activation of inflammatory caspases. Importantly, mutations in several members of the NLR family have been linked to a variety of inflammatory diseases consistent with these molecules playing an important role in host-pathogen interactions and the inflammatory response. In this review, we focus on the role of Nod1 and Nod2 in host defense and in particular discuss recent finding regarding the role of Nlrc4, Nlpr1, and Nlrp3 inflammasomes in caspase-1 activation and subsequent release of proinflammatory cytokines such as interleukin-1 beta.
Franchi
Luigi
L
Department of Pathology and Comprehensive Cancer Center, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Warner
Neil
N
Viani
Kyle
K
Nuñez
Gabriel
G
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000517:prevention & control; D020170:Caspase 1 / Q000276:immunology / Q000378:metabolism*; D020022:Genetic Predisposition to Disease; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D053583:Interleukin-1beta / Q000378:metabolism; D051379:Mice; D009154:Mutation; D053472:Nod Signaling Adaptor Proteins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D010587:Phagocytosis / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology
D053583:Interleukin-1beta; D053472:Nod Signaling Adaptor Proteins; D020170:Caspase 1