Upper-extremity deep vein thrombosis in a patient on clozapine therapy carrying the prothrombin G20210A mutation.
Clozapine treatment for resistant schizophrenic disorders has been associated to venous thromboembolic events. We report the case of a patient who developed upper-extremity deep vein thrombosis just 2 months after starting on clozapine in whom the thrombophilia work-up revealed the presence of the prothrombin G20210A mutation.
Vayá
Amparo
A
Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain. vaya_amp@gva.es
Lopez
Maria
M
Plumé
Gema
G
Ribes
José
J
D003024:Clozapine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D011516:Prothrombin / Q000235:genetics; D019851:Thrombophilia / Q000235:genetics; D034941:Upper Extremity; D020246:Venous Thrombosis / Q000188:drug therapy* / Q000235:genetics*
D011516:Prothrombin; D003024:Clozapine