Interleukin-5 and interleukin-10 are produced in central nervous system tumor cysts.
Interleukin-5 and interleukin-10, as important mediators of vascular permeability, contribute to the development of various pathologic effusions. However, little is known regarding the involvement of these two cytokines in the formation of cysts associated with central nervous system (CNS) tumors. Twenty-eight patients with various cystic CNS tumors were investigated for expression of interleukin-5 and interleukin-10 in cyst fluid and their matched cytokine receptors in tumor tissue. Interleukin-5 and interleukin-10 were detected in cyst fluid, and interleukin-5 concentration was significantly correlated with interleukin-10 concentration (r=0.508, p=0.006). Moreover, both receptors were also detectable in the tumor tissue specimens and high levels of expression were also found in perivascular cells. Therefore, the local production of interleukin-5 and interleukin-10 might be implicated in some types of cyst formation.
Li
Qiang
Q
Department of Neurosurgery, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan.
Oshige
Hideyuki
H
Zhen
Yunbo
Y
Yamahara
Takahiro
T
Oishi
Tetsuya
T
Seno
Toshitaka
T
Kawaguchi
Takuya
T
Numa
Yoshihiro
Y
Kawamoto
Keiji
K
D020863:Central Nervous System Cysts / Q000378:metabolism* / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D015848:Interleukin-5 / Q000378:metabolism*; D053701:Receptors, Interleukin-10 / Q000378:metabolism; D053649:Receptors, Interleukin-5 / Q000378:metabolism
D015848:Interleukin-5; D053701:Receptors, Interleukin-10; D053649:Receptors, Interleukin-5; D016753:Interleukin-10