title: Inhibitory effect of cranberry polyphenol on cariogenic bacteria.
abstract: The purpose of this study was to investigate the effect of cranberry polyphenol fraction on mutans streptococci. Hydrophobicity is an important factor in the adherence of bacteria to the tooth surface. We found that cranberry polyphenol fraction significantly decreased the hydrophobicity of Streptococcus sobrinus 6715, Streptococcus mutans MT8148R and JC2 in a dose-dependent manner (p<0.05). Biofilm formation by S. sobrinus 6715 and S. mutans MT8148R was inhibited by 100 microg/ml cranberry polyphenol fraction (p<0.01). When dosage was increased to 500 microg/ml, biofilm formation by S. mutans JC2 was significantly inhibited (p<0.05). Addition of 500 microg/ml cranberry polyphenol fraction to medium inhibited growth of S. mutans MT8148R compared with the control (p<0.05).
authors.affiliation: Department of Microbiology, Tokyo Dental College, Chiba, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Yamanaka-Okada
authors.forename: Emiko
authors.initials: E
authors.lastname: Sato
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kouchi
authors.forename: Ryuta
authors.initials: R
authors.lastname: Kimizuka
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kato
authors.forename: Katsuji
authors.initials: K
authors.lastname: Okuda
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D015169:Colony Count, Microbial; D005419:Flavonoids / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D010636:Phenols / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D059808:Polyphenols; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development; D016986:Streptococcus sobrinus / Q000187:drug effects / Q000254:growth & development; D029799:Vaccinium macrocarpon / Q000737:chemistry*
chemical_list: D000891:Anti-Infective Agents, Local; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols