title: Differences in grey and white matter atrophy in amnestic mild cognitive impairment and mild Alzheimer's disease.
abstract: BACKGROUND
  Grey matter (GM) atrophy has been demonstrated in amnestic mild cognitive impairment (aMCI) and mild Alzheimer's disease (AD), but the role of white matter (WM) atrophy has not been well characterized. Despite these findings, the validity of aMCI concept as prodromal AD has been questioned.
  
  
  METHODS
  We performed brain MRI with voxel-based morphometry analysis in 48 subjects, aiming to evaluate the patterns of GM and WM atrophy amongst mild AD, aMCI and age-matched normal controls.
  
  
  RESULTS
  Amnestic mild cognitive impairment GM atrophy was similarly distributed but less intense than that of mild AD group, mainly in thalami and parahippocampal gyri. There were no difference between aMCI and controls concerning WM atrophy. In the mild AD group, we found WM atrophy in periventricular areas, corpus callosum and WM adjacent to associative cortices.
  
  
  CONCLUSIONS
  We demonstrated that aMCI might be considered a valid concept to detect very early AD pathology, since we found a close proximity in the pattern of atrophy. Also, we showed the involvement of WM in mild AD, but not in aMCI, suggesting a combination of Wallerian degeneration and microvascular ischaemic disease as a plausible additional pathological mechanism for the discrimination between MCI and AD.
authors.affiliation: Department of Neurology, Medical School, University of Campinas, SP, Brazil.
authors.forename: M L F
authors.initials: ML
authors.lastname: Balthazar
authors.forename: C L
authors.initials: CL
authors.lastname: Yasuda
authors.forename: F R
authors.initials: FR
authors.lastname: Pereira
authors.forename: T
authors.initials: T
authors.lastname: Pedro
authors.forename: B P
authors.initials: BP
authors.lastname: Damasceno
authors.forename: F
authors.initials: F
authors.lastname: Cendes
mesh_terms: D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000473:pathology*; D000647:Amnesia / Q000150:complications / Q000473:pathology*; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000150:complications / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D009413:Nerve Fibers, Myelinated / Q000473:pathology*