title: Blunted autonomic response to volume expansion in formerly preeclamptic women with low plasma volume.
abstract: OBJECTIVE
  We hypothesize that low plasma volume in normotensive formerly preeclamptic women reflects reduced venous storage capacity. To test this hypothesis, we compared circulatory and autonomic responses to acute volume loading between women with low and those with normal plasma volume.
  
  
  METHODS
  In 24 normotensive formerly preeclamptic women at least 6 months postpartum, we administered 500 mL of iso-oncotic fluid by constant intravenous infusion in 30 minutes, while recording changes in heart rate, blood pressure, cardiac output, and measuring active plasma renin and alpha-atrial natriuretic peptide concentrations. We estimated arterial sympathetic control, cardiac autonomic regulatory balance, and baroreflex sensitivity using spectral analysis. Intergroup and intragroup changes were analyzed nonparametrically.
  
  
  RESULTS
  17 women (71%) had low plasma volume and 7 (29%) had normal plasma volume. Plasma volume expansion induced comparable changes in blood pressure, heart rate, baroreflex sensitivity, and active plasma renin concentration in low plasma volume and normal plasma volume. Cardiac output and alpha-atrial natriuretic peptide increased in low plasma volume but not in normal plasma volume. Volume expansion reduced sympathetic activity ( from 2.41 to 1.76 mm Hg(2), P = .03) in normal plasma volume but not in low plasma volume ( from 2.72 to 2.48 mm Hg(2), P > .05).
  
  
  CONCLUSIONS
  The sympathoinhibitory response to volume expansion is diminished in low plasma volume, which suggests that cardiovascular reflex function is impaired. We speculate that this defect contributes to circulatory maladaptation to pregnancy, sympathetic dominance, and the development of gestational hypertensive disease.
authors.affiliation: Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands. i.krabbendam@obgyn.umcn.nl
authors.forename: Ineke
authors.initials: I
authors.lastname: Krabbendam
authors.forename: Dorette A
authors.initials: DA
authors.lastname: Courtar
authors.forename: Ben J A
authors.initials: BJ
authors.lastname: Janssen
authors.forename: Robert
authors.initials: R
authors.lastname: Aardenburg
authors.forename: Louis L H
authors.initials: LL
authors.lastname: Peeters
authors.forename: Marc E A
authors.initials: ME
authors.lastname: Spaanderman
mesh_terms: D000328:Adult; D001341:Autonomic Nervous System / Q000502:physiology*; D005260:Female; D006801:Humans; D010953:Plasma Volume / Q000502:physiology*; D011225:Pre-Eclampsia / Q000097:blood / Q000503:physiopathology*; D011247:Pregnancy