Effector and memory CD4+ and CD8+ T cells in the chronic infection process.
T cell memory in comparison with B cell memory is not well understood. This review focuses on CD8+ and CD4+ memory T cells. In this article we try to define memory cells and also present models of memory T cells formation. We would also like to delineate their differentiation into distinct subsets. Long-lived memory T cells consist in two main subsets: TCM and TEM. Recent studies have shown that not all cells considered to be memory cells differentiate into TCM and TEM, but a small proportion of theses cells exhibit naive cells phenotype. Memory T cells constitute a heterogeneous population of cells. In this study we lay stress on characteristic of main memory T cells subsets and their alleged participation in immune response upon reexposure to the Ag.
Ojdana
Dominika
D
Department of Microbiological Diagnostics, Medical University of Bialystok, Poland.
Safiejko
Kamil
K
Lipska
Alina
A
Radziwon
Piotr
P
Dadan
Jacek
J
Tryniszewska
Elzbieta
E
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002908:Chronic Disease; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D007239:Infections / Q000276:immunology*; D018448:Models, Immunological