title: INHBA-associated markers as candidates for stallion fertility.
abstract: The inhibin beta A (INHBA) gene was chosen as candidate for stallion fertility and analysed for intragenic markers to find associations with pregnancy rate per oestrus. Intragenic single nucleotide polymorphisms (SNPs) were developed in order to perform an association and haplotype analysis using the least square means (LSM) of the pregnancy rate per oestrus for stallions as well as breeding values (BVs) for the embryonic and paternal component of the pregnancy rate per oestrus. The polymorphisms were genotyped in 161 Hanoverian warmblood stallions. Insemination records from approximately 20,000 Hanoverian warmblood mares were used to calculate LSM for stallions and to predict the paternal and embryonic component of BVs for the pregnancy rate per oestrus. We demonstrated significant associations of single markers and haplotypes with the LSM and the embryonic and paternal component of BVs for the pregnancy rate per oestrus. This is the first report on INHBA as an associated candidate gene with the LSM of stallions and the paternal and embryonic component of BVs for the pregnancy rate per oestrus.
authors.affiliation: Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Giesecke
authors.forename: H
authors.initials: H
authors.lastname: Hamann
authors.forename: H
authors.initials: H
authors.lastname: Sieme
authors.forename: O
authors.initials: O
authors.lastname: Distl
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood*; D030762:Estrous Cycle; D005260:Female; D005298:Fertility / Q000502:physiology*; D005819:Genetic Markers; D005838:Genotype; D006736:Horses / Q000502:physiology*; D028322:Inhibin-beta Subunits / Q000097:blood* / Q000235:genetics / Q000378:metabolism*; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D015415:Biomarkers; D005819:Genetic Markers; C103008:inhibin beta A subunit; D028322:Inhibin-beta Subunits