The KK-Periome database for transcripts of periodontal ligament development.
The periodontal ligament (PDL) is a strong connective tissue that surrounds the tooth root, absorbs occlusal forces, and functions as a sense organ. PDL originated from dental follicle (DF), which possessed mesenchymal progenitors in the developing tooth germ. However, as specific marker genes for PDL and DF are currently unavailable, the molecular mechanisms of PDL development are yet to be clarified. To facilitate the identification of such genes, we have previously established a transcriptome database of the human PDL (the KK-Periome database) and screened for specific genes expressed during PDL development. Initial screening of the database revealed two marker genes for distinguishing DF and PDL. The KK-Periome database thus appears to offer a useful resource for investigating genes involved in PDL development.
Saito
Masahiro
M
Department of Molecular and Cellular Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan. mssaito@dent.osaka-u.ac.jp
Nishida
Eisaku
E
Sasaki
Takashi
T
Yoneda
Toshiyuki
T
Shimizu
Nobuyoshi
N
D000818:Animals; D003094:Collagen / Q000235:genetics; D030541:Databases, Genetic; D018507:Gene Expression Regulation, Developmental; D005819:Genetic Markers; D016678:Genome; D015894:Genome, Human; D006801:Humans; D051379:Mice; D010513:Periodontal Ligament / Q000254:growth & development*; D011509:Proteoglycans / Q000235:genetics; D014158:Transcription, Genetic
D005819:Genetic Markers; D011509:Proteoglycans; D003094:Collagen