title: [Lipid profile in household contacts of patients with pulmonary tuberculosis].
abstract: BACKGROUND
  we have recently published the hypothesis that hypocholesterolemia might be a risk factor for the development of pulmonary tuberculosis. In this sense, albeit patients with pulmonary tuberculosis often have total cholesterol levels lower than the general population, it is not known if the latter have had a recent exposure to Mycobacterium tuberculosis.
  
  
  OBJECTIVE
  to evaluate serum lipids in subjects exposed to mycobacteria.
  
  
  METHODS
  we studied 25 pulmonary tuberculosis patients and 44 household contacts, and compared their serum lipid profile.
  
  
  RESULTS
  We found that total cholesterol, LDL and triglycerides concentrations increased with age in contacts but not in pulmonary tuberculosis patients, with statistically significant differences in regression lines (age versus lipid level). Multiple linear regression analysis confirmed that being a household contact was associated with higher levels of total cholesterol, LDL, HDL and triglycerides.
  
  
  CONCLUSIONS
  We conclude that lipid profile differed between pulmonary tuberculosis patients and their household contacts, thus supporting that low cholesterol levels might be a risk factor for developing pulmonary tuberculosis.
authors.affiliation: Unidad Médica de Atención Ambulatoria, Instituto Mexicano del Seguro Social, Coordinación de Investigación, Instituto de Salud del Estado de Aguascalientes, Aguascalientes, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Pérez-Guzmán
authors.forename: Mario H
authors.initials: MH
authors.lastname: Vargas
authors.forename: César
authors.initials: C
authors.lastname: Salas-Mártir
authors.forename: Teresa
authors.initials: T
authors.lastname: Trejo-Santacruz
authors.forename: Carlos
authors.initials: C
authors.lastname: Gallegos-Discua
authors.forename: Francisco
authors.initials: F
authors.lastname: Flores-López
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D005192:Family Health; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*; D014397:Tuberculosis, Pulmonary / Q000097:blood*; D055815:Young Adult
chemical_list: D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol