Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.
An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.
Gong
Gangli
G
Department of Medicine, Columbia University, 650 W 168th Street, BB 1029, New York, NY 10032, USA.
Xie
Yuli
Y
Liu
Yidong
Y
Rinderspacher
Alison
A
Deng
Shi-Xian
SX
Feng
Yan
Y
Zhu
Zhengxiang
Z
Tang
Yufei
Y
Wyler
Michael
M
Aulner
Nathalie
N
Toebben
Udo
U
Smith
Deborah H
DH
Branden
Lars
L
Chung
Caty
C
Schürer
Stephan
S
Vidović
Dusica
D
Landry
Donald W
DW
D020650:Combinatorial Chemistry Techniques; D006801:Humans; D019169:Jurkat Cells; D007976:Leupeptins / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D016328:NF-kappa B / Q000187:drug effects / Q000378:metabolism*; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology; D013454:Sulfoxides / Q000737:chemistry / Q000494:pharmacology; D013777:Tetrazoles / Q000737:chemistry / Q000494:pharmacology
C434003:3-(4-methylphenylsulfonyl)-2-propenenitrile; D007976:Leupeptins; D016328:NF-kappa B; D009570:Nitriles; D011799:Quinazolines; C461648:Ro 106-9920; D013450:Sulfones; D013454:Sulfoxides; D013777:Tetrazoles; C072553:benzyloxycarbonylleucyl-leucyl-leucine aldehyde