[Influence of recombinant human growth hormone on body fluid compartments and water-sodium retention in severe burn patients].
OBJECTIVE
To investigate the influence of recombinant human growth hormone (rhGH) on body fluid compartments and water-sodium retention in severe burn patients.


METHODS
Thirty adult patients with severe burn were divided into treatment (T) and control (C) groups by block randomized design. Patients in both groups were subcutaneously injected with same amount of rhGH (12 IU/d) or isotonic saline during 7 - 21 post burn day (PBD). The total body water (TBW), intracellular water (ICW), extracellular water (ECW) were measured by bioelectrical impedance analysis (BIA) on 7, 14, 21 PBD. The 24 h urinary output of Na+ was determined by ion selective electrode method (ISE).


RESULTS
There were no significant difference in levels of TBW, ICW, ECW and 24 h urinary output of Na+ between two groups on 7, 14, 21 PBD (P > 0.05). No difference in results was found between groups at different time points (P > 0.05). After the data were analyzed, the level of TBW (36 +/- 6 L), ICW (21 +/- 4 L) on 21 PBD were evidently lower than those on 7 PBD (38 +/- 6 L, 23 +/- 7 L, P < 0.01).


CONCLUSIONS
The level of ICW and TBW in severe burn patients decreased along with the time. Proper dosage of rhGH has no significant effect on body fluid compartments and water-sodium retention.
Shao
Hua-wei
HW
Department of Burns, Second Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou 310009, PR China.
Qiu
Xu-guang
XG
Chen
Guo-xian
GX
Han
Chun-mao
CM
D000293:Adolescent; D000328:Adult; D000368:Aged; D001825:Body Fluid Compartments; D001834:Body Water; D002056:Burns / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy*; D004487:Edema / Q000209:etiology*; D017097:Electric Impedance; D005110:Extracellular Space; D005260:Female; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000378:metabolism; D055815:Young Adult
D019382:Human Growth Hormone; D012964:Sodium