Role of collagen deposition in lymphatic tissues and immune reconstruction during HIV-1 and SIV infections.
The hallmark of HIV-1/simian immunodeficiency virus infections is the progressive depletion of CD4(+) T cells that ultimately renders the host incapable of defending against AIDS-defining opportunistic infections and malignancies. Although many potential mechanisms have been proposed to explain CD4(+) T-cell loss, this review focuses on the growing evidence that collagen deposition and consequent fibrotic damage to the lymphatic tissue T-cell compartment contributes to CD4(+) T-cell decline and limits CD4(+) T-cell repopulation, even with highly active antiretroviral therapy.
Estes
Jacob D
JD
The AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick, Inc., National Cancer Institute-Frederick, Fort Detrick Campus, Frederick, MD 21702, USA. estesj@mail.nih.gov
D000328:Adult; D000818:Animals; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002648:Child; D003094:Collagen / Q000378:metabolism*; D005355:Fibrosis / Q000276:immunology / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome; D008221:Lymphoid Tissue / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000472:pathogenicity*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D003094:Collagen