Macrophage inhibitory cytokine-1: a new player in melanoma development.
Macrophage inhibitory cytokine-1 (MIC-1) is a divergent member of the TGF-beta superfamily. Although it has been reported to exhibit both tumorigenic and antitumorigenic activities, Boyle et al. report in this issue that MIC-1 expression was correlated with the tumorigenicity of melanoma cells. The elucidation of signaling pathways around MIC-1 might contribute to prospective targeting therapy for melanoma.
Yamashita
Toshiharu
T
Department of Dermatology, Sapporo Medical University, Sapporo, Japan. yamasita@sapmed.ac.jp
Yoneta
Akihiro
A
Hida
Tokimasa
T
D015972:Gene Expression Regulation, Neoplastic; D055436:Growth Differentiation Factor 15 / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000276:immunology*; D012878:Skin Neoplasms / Q000235:genetics* / Q000276:immunology*
C526140:GDF15 protein, human; D055436:Growth Differentiation Factor 15