title: High-yielding synthesis of the anti-influenza neuramidase inhibitor (-)-oseltamivir by three "one-pot" operations.
abstract: Taking shortcuts: A remarkably short and high-yielding asymmetric total synthesis of (-)-oseltamivir takes advantage of organocatalysis and single-pot domino operations. The target, known as the drug Tamiflu, is prepared efficiently in a short time, and also its derivatives can be synthesized effectively.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan.
authors.forename: Hayato
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Takaki
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D002384:Catalysis; D004987:Ethers / Q000737:chemistry; D006801:Humans; D007251:Influenza, Human / Q000188:drug therapy*; D053139:Oseltamivir / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use; D011392:Proline / Q000031:analogs & derivatives / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000998:Antiviral Agents; D004987:Ethers; C529940:diphenylprolinol silyl ether; D053139:Oseltamivir; D011392:Proline