ESCRTing membrane deformation.
The ESCRT-III complex mediates membrane budding away from the cytosol in endosome biogenesis, cytokinesis, and viral budding. In this issue, Saksena et al. (2009) use an elegant fluorescence-based approach to define the sequential activation, recruitment, and disassembly of ESCRT-III subunits during membrane involution in vitro.
Malerød
Lene
L
Centre of Cancer Biomedicine, Faculty of Medicine, University of Oslo, Montebello, N-0310 Oslo, Norway.
Stenmark
Harald
H
D003600:Cytosol / Q000737:chemistry / Q000378:metabolism; D011992:Endosomes / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D013050:Spectrometry, Fluorescence; D033921:Vesicular Transport Proteins / Q000737:chemistry* / Q000378:metabolism*; D015003:Yeasts
D033921:Vesicular Transport Proteins