Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy.
Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA.
Tsai
Li-Kai
LK
Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Yang
Chih-Chao
CC
Ting
Chen-Hung
CH
Su
Yi-Ning
YN
Hwu
Wuh-Liang
WL
Li
Hung
H
D000328:Adult; D017668:Age of Onset; D000818:Animals; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D051379:Mice; D009134:Muscular Atrophy, Spinal / Q000145:classification / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055532:SMN Complex Proteins / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
D012333:RNA, Messenger; D055532:SMN Complex Proteins