The role of nitric oxide in biocompatibility.
Inflammation is a major factor in the development of the foreign body response to biomaterials and medical devices, including compatibility with blood, and the mechanisms are obviously complex. It has been realised recently that nitric oxide (NO) gas is continuously generated by some cells in the body and that the molecules of this gas are able to modulate inflammatory and thrombotic processes. The challenge has then become one of incorporating NO releasing materials into medical devices to control biocompatibility.
Williams
David
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Consulting Services, Morgan & Masterson, Brussels, Belgium. peggy@morgan-masterson.com
D001672:Biocompatible Materials / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000737:chemistry / Q000276:immunology*; D016459:Prosthesis-Related Infections / Q000276:immunology* / Q000517:prevention & control*
D001672:Biocompatible Materials; D004337:Drug Carriers; D009569:Nitric Oxide