Differential numbers of foci of lymphocytes within the brains of Lewis rats exposed to weak complex nocturnal magnetic fields during development of experimental allergic encephalomyelitis.
To discern if specific structures of the rat brain contained more foci of lymphocytes following induction of experimental allergic encephalomyelitis and exposures to weak, amplitude-modulated magnetic fields for 6 min once per hour during the scotophase, the residuals between the observed and predicted values for the numbers of foci for 320 structures were obtained. Compared to the brains of sham-field exposed rats, the brains of rats exposed to 7-Hz 50 nT (0.5 mG) amplitude-modulated fields showed more foci within hippocampal structures and the dorsal central grey of the midbrain while those exposed to 7-Hz 500 nT (5 mG) fields showed greater densities within the hypothalamus and optic chiasm. The brains of rats exposed to either the 50 nT or 500 nT amplitude-modulated 40-Hz fields displayed greater densities of foci within the midbrain structures related to rapid eye movement. Most of the enhancements of infiltrations within the magnetic field-exposed rats occurred in structures within periventricular or periaqueductal regions and were both frequency- and intensity-dependent. The specificity and complexity of the configurations of the residuals of the numbers of infiltrated foci following exposures to the different fields suggest that the brain itself may be a "sensory organ" for the detection of these stimuli.
Persinger
Michael A
MA
Behavioural Neuroscience and Biomolecular Sciences Programs, Laurentian University, Sudbury, Ontario, Canada. mpersinger@laurentian.ca
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000276:immunology / Q000528:radiation effects*; D002552:Cerebral Ventricles / Q000502:physiology; D002634:Chemotaxis, Leukocyte / Q000276:immunology / Q000528:radiation effects; D002940:Circadian Rhythm / Q000276:immunology / Q000528:radiation effects*; D004195:Disease Models, Animal; D004574:Electromagnetic Fields; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000503:physiopathology*; D005260:Female; D006624:Hippocampus / Q000276:immunology / Q000528:radiation effects; D007031:Hypothalamus / Q000276:immunology / Q000528:radiation effects; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008214:Lymphocytes / Q000528:radiation effects*; D008636:Mesencephalon / Q000276:immunology / Q000528:radiation effects; D009897:Optic Chiasm / Q000276:immunology / Q000528:radiation effects; D051381:Rats; D011917:Rats, Inbred Lew; D012895:Sleep, REM / Q000276:immunology / Q000528:radiation effects