Making imines without making water-exploiting a recognition-mediated aza-wittig reaction.
A recognition-mediated aza-Wittig reaction permits the efficient formation of an imine in dry CDCl(3) from an iminophosphorane and an aldehyde. The kinetic and thermodynamic parameters for this reaction are compared with those obtained from a condensation reaction between an aldehyde and an amine that forms the same product.
del Amo
Vicente
V
EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St. Andrews, North Haugh, St. Andrews, Fife KY16 9ST, United Kingdom.
Philp
Douglas
D
D001372:Aza Compounds / Q000737:chemistry*; D002725:Chloroform / Q000737:chemistry; D003903:Deuterium / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D007700:Kinetics; D014867:Water / Q000737:chemistry
D001372:Aza Compounds; D007097:Imines; D014867:Water; D002725:Chloroform; D003903:Deuterium