title: Molecular cloning and expression of several new Anopheles cracens epsilon class glutathione transferases.
abstract: Glutathione transferases, GSTs, are detoxification proteins that are found in most organisms. The acGSTE3-3 had the ability to conjugate 4-hydroxynonenal, a cytotoxic lipid peroxidation product. Although other Epsilon GSTs showed roles in insecticide metabolism, the acGSTE3-3 appeared to have a major role in detoxifying lipid peroxidation products conferring protection against oxidative damage.
authors.affiliation: Institute of Molecular Biology and Genetics, Mahidol University, Salaya Campus, Nakhon Pathom 73170, Thailand.
authors.forename: Jeerang
authors.initials: J
authors.lastname: Wongtrakul
authors.forename: Jantana
authors.initials: J
authors.lastname: Wongsantichon
authors.forename: Ardcharaporn
authors.initials: A
authors.lastname: Vararattanavech
authors.forename: Posri
authors.initials: P
authors.lastname: Leelapat
authors.forename: La-aied
authors.initials: LA
authors.lastname: Prapanthadara
authors.forename: Albert J
authors.initials: AJ
authors.lastname: Ketterman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000852:Anopheles / Q000201:enzymology*; D003001:Cloning, Molecular; D005982:Glutathione Transferase / Q000037:antagonists & inhibitors / Q000235:genetics* / Q000378:metabolism; D007305:Insecticide Resistance / Q000502:physiology; D007700:Kinetics; D008969:Molecular Sequence Data; D005810:Multigene Family; D009570:Nitriles / Q000494:pharmacology; D026023:Permethrin / Q000494:pharmacology; D011722:Pyrethrins / Q000494:pharmacology; D016415:Sequence Alignment; D013379:Substrate Specificity
chemical_list: D009570:Nitriles; D011722:Pyrethrins; D026023:Permethrin; D005982:Glutathione Transferase; C037304:cyhalothrin