title: Haplotype analysis of the CYP8A1 gene associated with myocardial infarction.
abstract: OBJECTIVE
  The aim of this study was to assess the association between the human CYP8A1 gene and myocardial infarction (MI) in Chinese people.
  
  
  METHODS
  210 MI patients and 206 age-matched controls were genotyped and constructed haplotypes for 3 SNPs [3982C>T (rs5602), C1117A (rs5629), C251T (rs454-98106)] of the human CYP8A1 gene.
  
  
  RESULTS
  The CC genotype of rs5629 was more frequently in MI patients than in control subjects (P = .030). The frequency of the A-C-T haplotype was significantly higher in MI patients than in control subjects (P =.001). The frequency of the C-T-T haplotype was significantly lower in MI patients than in control subjects (P= .011).
  
  
  CONCLUSIONS
  The present results indicate that MI is associated with the CC genotype of rs5629 in the human CYP8A1 gene. The A-C-T haplotype appears to be a useful genetic marker and the C-T-T haplotype might be a protective factor of MI in Chinese people.
authors.affiliation: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
authors.lastname: Xiang Xie
authors.forename: Yi-Tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Zhen-Yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Yang
authors.lastname: Xiang Ma
authors.forename: Bang-Dang
authors.initials: BD
authors.lastname: Chen
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Wang
authors.lastname: Fen Liu
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002681:China; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D003577:Cytochrome P-450 Enzyme System; C472456:PTGIS protein, human