Autoantibodies against glutamate, gamma-aminobutyric acid, and norepinephrine in mechanisms of neuropathic pain syndrome.
The production and role of autoantibodies against neurotransmitters glutamate, gamma-aminobutyric acid, and norepinephrine were studied in rats with experimental neuropathic pain syndrome induced by sciatic nerve transection. Nerve transection in rats was followed by behavioral reaction of autotomy (self-mutilation of the operated limb), which often accompanies neuropathic pain syndrome. The development of neuropathic pain syndrome was accompanied by increased production of autoantibodies against glutamate, gamma-aminobutyric acid, and norepinephrine. A negative correlation was found between the amount of autoantibodies against neurotransmitters and severity of neuropathic pain syndrome. Our results suggest that antibodies against glutamate and norepinephrine exhibit protective activity.
Evseev
V A
VA
Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
Vetrile
L A
LA
Smirnova
V S
VS
Grafova
V N
VN
Zaharova
I A
IA
Trekova
N A
NA
Kukushkin
M L
ML
D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D020918:Complex Regional Pain Syndromes / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control; D018698:Glutamic Acid / Q000276:immunology; D008297:Male; D018377:Neurotransmitter Agents / Q000276:immunology*; D009619:Nociceptors / Q000276:immunology / Q000502:physiology; D009638:Norepinephrine / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries; D005680:gamma-Aminobutyric Acid / Q000276:immunology
D001323:Autoantibodies; D018377:Neurotransmitter Agents; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D009638:Norepinephrine