title: Dynamic perfusion patterns in temporal lobe epilepsy.
abstract: OBJECTIVE
  To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE).
  
  
  METHODS
  We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion changes and temporal relationships with injection time and seizure duration as covariates.
  
  
  RESULTS
  The analysis revealed significant ictal hyperperfusion in the ipsilateral temporal lobe extending to subcortical regions. Hypoperfusion was observed in large extratemporal areas. There were also significant dynamic changes in several extratemporal regions: ipsilateral orbitofrontal and bilateral superior frontal gyri and the contralateral cerebellum and ipsilateral striatum.
  
  
  CONCLUSIONS
  The study demonstrated early dynamic perfusion changes in extratemporal regions probably involved in both propagation of epileptic activity and initiation of inhibitory mechanisms.
authors.affiliation: Nuclear Medicine, Medical Imaging Center and Neurology, KU Leuven/UZ Gasthuisberg, Leuven, Belgium.
authors.forename: Patrick
authors.initials: P
authors.lastname: Dupont
authors.forename: John J
authors.initials: JJ
authors.lastname: Zaknun
authors.forename: Alex
authors.initials: A
authors.lastname: Maes
authors.forename: Supatporn
authors.initials: S
authors.lastname: Tepmongkol
authors.forename: Silvia
authors.initials: S
authors.lastname: Vasquez
authors.forename: C S
authors.initials: CS
authors.lastname: Bal
authors.forename: Wim
authors.initials: W
authors.lastname: Van Paesschen
authors.forename: Silvina
authors.initials: S
authors.lastname: Carpintiero
authors.forename: Chaichon
authors.initials: C
authors.lastname: Locharernkul
authors.forename: Maurizio
authors.initials: M
authors.lastname: Dondi
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D010477:Perfusion; D012640:Seizures / Q000175:diagnosis / Q000000981:diagnostic imaging; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*