title: Linkage and association study of FcgammaR polymorphisms in celiac disease.
abstract: The Fcgamma receptor cluster on chromosome 1q23 contains a number of genes that may affect susceptibility to celiac disease, but previous studies have yielded contradictory results. We studied the FcgammaRIIa*A519G (rs1801274) and FcgammaRIIIa*A559C (rs396991) single nucleotide polymorphisms in celiac disease families from Hungary and Finland and in celiac disease case-control materials from Hungary and Italy. Neither the Hungarian nor the Italian case-control material or a meta-analysis of the combined case-control material showed significant single-marker or haplotype association. In addition, neither linkage nor family-based association tests showed evidence for association in the Finnish or Hungarian family material. This study thus does not support a previous publication showing FcgammaR association with celiac disease.
authors.affiliation: Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
authors.forename: I
authors.initials: I
authors.lastname: Sareneva
authors.forename: L L E
authors.initials: LL
authors.lastname: Koskinen
authors.forename: I R
authors.initials: IR
authors.lastname: Korponay-Szabo
authors.forename: K
authors.initials: K
authors.lastname: Kaukinen
authors.forename: K
authors.initials: K
authors.lastname: Kurppa
authors.forename: F
authors.initials: F
authors.lastname: Ziberna
authors.forename: S
authors.initials: S
authors.lastname: Vatta
authors.forename: T
authors.initials: T
authors.lastname: Not
authors.forename: A
authors.initials: A
authors.lastname: Ventura
authors.forename: R
authors.initials: R
authors.lastname: Adány
authors.forename: Z
authors.initials: Z
authors.lastname: Pocsai
authors.forename: G
authors.initials: G
authors.lastname: Széles
authors.forename: M
authors.initials: M
authors.lastname: Mäki
authors.forename: P
authors.initials: P
authors.lastname: Saavalainen
authors.forename: E
authors.initials: E
authors.lastname: Einarsdottir
mesh_terms: D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007558:Italy / Q000453:epidemiology; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
chemical_list: C496124:FCGR3A protein, human; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG