Burkholderia pseudomallei: animal models of infection.
A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease. In mice, and depending on the route of infection, dose, and mouse strain, the disease can range from a chronic, and in some cases, an apparently latent infection to an acute fulminant disease. Alternative small animal models of infection include diabetic rats or hamsters. Larger animal models of disease have not yet been fully developed. It is not clear which of the small animal models of melioidosis most accurately reflect disease in humans. However, the findings that diabetic rats are susceptible to infection, that some strains of mice can develop persistent subclinical infections that can spontaneously reactivate, and that inhalation exposure generally results in more acute disease suggest that these different models mimic different aspects of human melioidosis.
Titball
Richard W
RW
School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter EX4 4QD, UK. r.w.titball@exeter.ac.uk
Russell
Paul
P
Cuccui
Jon
J
Easton
Anna
A
Haque
Ashraful
A
Atkins
Tim
T
Sarkar-Tyson
Mitali
M
Harley
Vicki
V
Wren
Brendan
B
Bancroft
Gregory J
GJ
D000818:Animals; D001428:Bacterial Vaccines; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006224:Cricetinae; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D006041:Goats; D006801:Humans; D008554:Melioidosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D011323:Primates; D051381:Rats; D055502:Secondary Prevention; D013045:Species Specificity; D014774:Virulence / Q000235:genetics
D001428:Bacterial Vaccines