title: Quetiapine effective in treatment of inappropriate sexual behavior of lewy body disease with predominant frontal lobe signs.
abstract: Dementia of Lewy body disease is the second most common degenerative cause of dementia after Alzheimer's disease, among all the dementias. The core features are a progressive dementia, fluctuations in cognitive functions, visual hallucinations, and spontaneous parkinsonism. Rapid eye movement sleep behavior disorder, severe neuroleptic sensitivity, and low dopamine transporter uptake in basal ganglia are other suggestive features. Behavioral abnormalities are commonly present in the form of aggressive behavior, irritability, and uninhibited behaviors. These are mostly seen in the advanced stages of dementia. However, inappropriate sexual behavior is uncommonly seen in such cases. Three types of inappropriate sexual behaviors commonly found in cases of dementia are sex talks, sexual acts, and implied sexual acts. Such inappropriate sexual behaviors have not been described adequately in dementia of Lewy body disease. We report inappropriate sexual behaviors in a case of dementia of Lewy body disease, which improved rapidly after treatment with quetiapine.
authors.affiliation: Central Institute of Psychiatry, Ranchi, India. drravi2121@gmail.com
authors.forename: Ravi
authors.initials: R
authors.lastname: Prakash
authors.forename: Amit
authors.initials: A
authors.lastname: Pathak
authors.forename: Sanjay
authors.initials: S
authors.lastname: Munda
authors.forename: Dhruv
authors.initials: D
authors.lastname: Bagati
mesh_terms: D014150:Antipsychotic Agents / Q000008:administration & dosage*; D003987:Dibenzothiazepines / Q000008:administration & dosage*; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D020961:Lewy Body Disease / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D001523:Mental Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008875:Middle Aged; D000069348:Quetiapine Fumarate; D020018:Sexual Dysfunctions, Psychological / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate