title: The contribution of cis-regulatory elements to head-to-head gene pairs' co-expression pattern.
abstract: Transcription regulation is one of the most critical pipelines in biological process, in which cis-elements play the role as gene expression regulators. We attempt to deduce the principles underlying the co-expression of "head-to-head" gene pairs by analyzing activities or behaviors of the shared cis-elements. A network component analysis was performed to estimate the impact of cis-elements on gene promoters and their activities under different conditions. Our discoveries reveal how biological system uses those regulatory elements to control the expression pattern of "head-to-head" gene pairs and the whole transcription regulation system.
authors.affiliation: School of Life Sciences, Fudan University, Shanghai, 200433, China.
authors.forename: Pei
authors.initials: P
authors.lastname: Hao
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.forename: XiaoYan
authors.initials: X
authors.lastname: Zhang
authors.forename: Kang
authors.initials: K
authors.lastname: Tu
authors.forename: HaiWei
authors.initials: H
authors.lastname: Fan
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhong
mesh_terms: D005786:Gene Expression Regulation / Q000235:genetics*; D050436:Regulatory Elements, Transcriptional / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000235:genetics