title: Study of bipathic effect of haloperidol.
abstract: Parallel treatment with haloperidol and ultralow-dose haloperidol significantly increased the psychotropic neuroleptic effect of traditional doses of the drug under conditions of preliminary of simultaneous administration, which attests to a bipathic effect of this preparation. Combination of ultralow and therapeutic doses of haloperidol significantly reduced its cataleptogenic side effect.
authors.affiliation: Materia Medica Holding, Moscow, Russia. nauka@materiamedica.ru
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
authors.forename: M V
authors.initials: MV
authors.lastname: Belopolskaya
authors.forename: I A
authors.initials: IA
authors.lastname: Kheyfets
authors.forename: J L
authors.initials: JL
authors.lastname: Dugina
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001058:Apomorphine / Q000008:administration & dosage; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D018491:Dopamine Agonists / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018727:Muscarinic Antagonists / Q000008:administration & dosage; D013239:Stereotyped Behavior / Q000187:drug effects; D014282:Trihexyphenidyl / Q000008:administration & dosage
chemical_list: D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D018727:Muscarinic Antagonists; D014282:Trihexyphenidyl; D006220:Haloperidol; D001058:Apomorphine