Notch 1 keeps pro-T cells on track.
In this issue of Immunity, Feyerabend et al. (2009) report that Delta-like 4, acting on Notch 1, prevents pro-T cells from differentiating into dendritic cells and B cells. In addition, in the absence of Notch 1, B cells in the thymus arose from a cell-extrinsic pathway.
von Boehmer
Harald
H
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
D000818:Animals; D019070:Cell Lineage / Q000276:immunology*; D006801:Humans; D051881:Receptor, Notch1 / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D051881:Receptor, Notch1