Secondary metabolites of Tubercularia sp. TF5, an endophytic fungal strain of Taxus mairei.
One new diterpene glycoside (1) named 16-O-alpha-D-tetraacetylglucopyranosyl hymatoxin C, along with eight known ones including two diterpenoids (2, 3), three cytochalasins (4, 5, 6), dihydroisocoumarin (7) and two C(7)-tetraketides (8, 9), were isolated from the culture of the endophytic fungal strain Tubercularia sp. TF5. The structures of compounds 1-9 were elucidated by spectroscopic methods. The cytotoxic and antimicrobial activities of 1 were analysed but showed no significant activities.
Li
Yaoyao
Y
Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen, Fujian, P.R. China.
Lu
Chunhua
C
Hu
Zhiyu
Z
Huang
Yaojian
Y
Shen
Yuemao
Y
D002681:China; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003572:Cytochalasins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D020946:Taxus / Q000382:microbiology*
C534668:16-O-alpha-D-tetraacetylglucopyranosyl hymatoxin C; D003374:Coumarins; D003572:Cytochalasins; D004224:Diterpenes; D005960:Glucosides; D018942:Macrolides