title: Sustained benefit of left ventricular remodelling after valve replacement for aortic stenosis.
abstract: BACKGROUND
  Valve replacement for aortic stenosis (AS) determines negative ventricular remodelling. We used cross sectional and Doppler echocardiography to check how rapidly it occurs and to assess if these changes are sustained over time.
  
  
  METHODS
  We evaluated in 34 patients subjected to aortic valve replacement for AS morphological and functional (ejection fraction and E:A ratio) left ventricular data by echocardiography prior to surgery and 2 postoperative studies: early after surgery (pQ1) and at mid-term evolution (pQ2).
  
  
  RESULTS
  Left ventricular mass index was reduced at pQ1 (from 152 +/- 47 g/m2 to 113 +/- 31 g/m2; p < 0.01) as well as end-diastolic (from 51.3 mm to 48.3 mm; p < 0.03), end-systolic (from 32.2 mm to 29.4 mm; p < 0.02), interventricular septum (from 12.9 mm to 10.3 mm; p < 0.01), and posterior wall (from 12.5 mm to 11 mm; p < 0.01) dimensions. Left ventricular ejection fraction (from 61.2% to 65.2%; p < 0.04) and E:A ratio (from 0.94 to 0.98; p < 0.01) increased significantly at pQ1. There were no significant differences in measurements between pQ1 and pQ2.
  
  
  CONCLUSIONS
  Aortic valve replacement surgery leads to a rapid negative left ventricular remodelling during the first 7 months, including a decrease in myocardial hypertrophy and an improvement in systolic and diastolic function. These beneficial hemodynamic changes are sustained for at least 3 years.
authors.affiliation: Department of Cardiology, Lozano Blesa Universitary Clinic Hospital, Zaragoza, Spain. joselinares1979@hotmail.com
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Linares Vicente
authors.forename: Isaac
authors.initials: I
authors.lastname: Lacambra Blasco
authors.forename: Pilar
authors.initials: P
authors.lastname: Portero Perez
authors.forename: Maria Rosario
authors.initials: MR
authors.lastname: Ortas Nadal
authors.forename: Borja
authors.initials: B
authors.lastname: Simo Sanchez
authors.forename: Isaac
authors.initials: I
authors.lastname: Pascual Calleja
authors.forename: Jose Ramón
authors.initials: JR
authors.lastname: Ruiz  Arroyo
authors.forename: Mariano
authors.initials: M
authors.lastname: González Carretero
authors.forename: Alfonso
authors.initials: A
authors.lastname: Del Rio Ligorit
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D015150:Echocardiography, Doppler; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013318:Stroke Volume; D013997:Time Factors; D016896:Treatment Outcome; D020257:Ventricular Remodeling