Intracranial reparative giant cell granuloma secondary to cholesteatoma in a 15-year-old girl.
A 15-year-old girl presented with pain in the right ear and acute onset of total peripheral facial nerve palsy. Imaging studies revealed an intracranial mass of the right temporal bone causing temporal lobe displacement. A first biopsy led to the diagnosis of intracranial giant cell reparative granuloma (GCRG), a rare benign tumor of the bone or soft tissue that can show expansive growth. The etiology of GCRG is unclear. Facial nerve palsy responded to treatment with diclofenac and physiotherapy, however, the intracranial lesion progressed at follow-up. Total surgical excision revealed a cholesteatoma central to the GCRG originating from the right middle ear and mastoid. Cholesteatoma should be considered as a trigger for intracranial GCRG growth, especially if adjacent to the temporal bone.
Moser
Andrea
A
Division of Pediatric Hematology/Oncology, University Clinic of Pediatrics and Adolescent Medicine, Medical University Graz, Austria. andrea.moser@klinikum-graz.at
Hoffmann
Karl M
KM
Walch
Christian
C
Sovinz
Petra
P
Lackner
Herwig
H
Schwinger
Wolfgang
W
Benesch
Martin
M
Fritz
Gerald
G
Urban
Christian
C
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001847:Bone Diseases / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018424:Cholesteatoma, Middle Ear / Q000150:complications* / Q000473:pathology / Q000601:surgery; D004008:Diclofenac / Q000627:therapeutic use; D005158:Facial Paralysis / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006101:Granuloma, Giant Cell / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D013701:Temporal Bone; D014057:Tomography, X-Ray Computed
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac