Carotid barochemoreceptor pathological findings regarding carotid plaque status and aging.
BACKGROUND
Carotid barochemoreceptor pathological lesions have been studied in animals, but few human necropsies have been performed. Therefore, data rely on case patients following surgery, radiotherapy and carotid endarterectomy. Almost no data are available regarding whether the effect of aging prevails over pathological conditions, despite the classic description that glomic fibrosis increases with age.


OBJECTIVE
To morphometrically characterize the alterations of the carotid barochemoreceptors and their supplying arteries.


METHODS
Patients (n=23) who had suffered and died from stroke, with and without complicated internal carotid atheromatosis, were divided by age (group 1: older than 80 years; group 2: 65 to 80 years; and group 3: younger than 65 years). Carotid segments were obtained at autopsy. The specimens were stained for light microscopy and immunohistochemistry.


RESULTS
Carotid glomus presented from moderate-to-severe atrophy and fibrosis. A focal decrease in vascularization (CD34-positive) of the glomus (greater than 50%) was observed in areas of atrophy and fibrosis. Damaged nerve endings (S100 protein-positive) were observed at the media of the carotid sinus. Morphometric data showed no differences between groups for glomus area, number of type 1 and 2 cells, and the wall to lumen arteriole ratio. No statistical differences were demonstrated in the pathological findings of the carotid glomus when comparing complicated with noncomplicated plaques or age groups.


CONCLUSIONS
Severe carotid chemoreceptor damage exists in patients who have died from stroke and suffered from carotid atheromatosis. These findings were independent from aging and plaque type. However, damage was correlated with a marked narrowing of the supplying arterioles as a consequence of hemodynamic and/or metabolic alterations (dyslipidemia, diabetes).
Milei
José
J
Instituto de Investigaciones Cardiológicas, Universidad de Buenos Aires, Buenos Aires, Argentina. ininca@fmed.uba.ar
Lavezzi
Anna M
AM
Bruni
Barbara
B
Grana
Daniel R
DR
Azzato
Francisco
F
Matturri
Luigi
L
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology; D001344:Autopsy; D002339:Carotid Arteries / Q000473:pathology*; D016893:Carotid Stenosis / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D011311:Pressoreceptors / Q000473:pathology*; D020521:Stroke / Q000473:pathology*