Surugapyrroles A and B, two new N-hydroxypyrroles, as DPPH radical-scavengers from Streptomyces sp. USF-6280 strain.
Two new N-hydroxypyrroles, surugapyrroles A and B, were isolated as DPPH radical-scavengers from a culture broth of Streptomyces sp. USF-6280 strain. The structures of the two compounds were elucidated by spectroscopic evidences and derivatization. Their DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity was as high as that of butylhydroxytoluene (BHT): surugapyrrole A, ED(50) 50.3 microM; surugapyrrole B, ED(50) 75.8 microM.
Sugiyama
Yasumasa
Y
Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka.
Watanabe
Kei
K
Hirota
Akira
A
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010851:Picrates; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry*
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D011758:Pyrroles; C004931:1,1-diphenyl-2-picrylhydrazyl