Spectral tuning of azobenzene photoswitches for biological applications.
Longer switching wavelengths and good photochemical yields and stabilities of the cis isomers in reducing aqueous environments are achieved by introducing 2,2'-aminoalkyl substituents into 4,4'-diamido-substituted azobenzenes. The products are thus suitable for photocontrol of biomolecular structures in intracellular environments, such as switching between two peptide configurations (see picture).
Sadovski
Oleg
O
Department of Chemistry, University of Toronto, 80 St. George St., Toronto, Canada.
Beharry
Andrew A
AA
Zhang
Fuzhong
F
Woolley
G Andrew
GA
D001391:Azo Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000528:radiation effects; D002942:Circular Dichroism; D010455:Peptides / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
D001391:Azo Compounds; D010455:Peptides; C009850:azobenzene