title: [Serious adverse events derived from the drug interactions of antiretroviral therapy].
abstract: OBJECTIVE
  Antiretroviral drugs can cause drug interactions.
  
  
  METHODS
  Three clinical cases are described regarding HIV-infected patients in which a clinically relevant adverse effect occurred due to a pharmacokinetic interaction.
  
  
  RESULTS
  Case 1: A 43-year old woman being treated with tenofovir DF, emtricitabine and lopinavir/ritonavir who presents ischemia in both upper extremities following an ergotamine syndrome. Case 2: A 54-year old man being treated with zidovudine, lamivudine and lopinavir/ritonavir who presents Cushing syndrome following to use of inhaled fluticasone. Case 3: A 45-year old man being treated with tenofovir DF, emtricitabine and atazanavir/ritonavir who presents a virological failure as consequence of concomitant use of omeprazole.
  
  
  CONCLUSIONS
  Potential drug interactions must be considered when other concomitant drugs are used with antiretroviral therapy especially when one of these is a P 450 cytochrome enzymatic inductor or inhibitor.
authors.affiliation: Servicio de Medicina Interna, Hospital de Móstoles, Madrid, España.
authors.forename: M
authors.initials: M
authors.lastname: Morales Conejo
authors.forename: V J
authors.initials: VJ
authors.lastname: Moreno Cuerda
authors.forename: J
authors.initials: J
authors.lastname: Abellán Martínez
authors.forename: R
authors.initials: R
authors.lastname: Rubio
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D044966:Anti-Retroviral Agents; D003577:Cytochrome P-450 Enzyme System