Chemoenzymatic synthesis of small molecule human therapeutics.
Pharmaceuticals have historically been produced by either chemical synthesis or whole cell fermentation. The former is applied to synthetic small molecules while the latter to natural products. As a result of recent advances in rapid discovery of enzymes through genome mining and metagenomics, and their tunability in functions and stability through directed evolution, biocatalysis is emerging to be a transformational technology for drug discovery and production. Enzymes can catalyze reactions otherwise challenging by chemical approaches. Furthermore, enzymatic catalysis is a powerful tool for green chemistry development. This manuscript gives a brief overview of current status in integrating chemical and biological transformations for the synthesis of small molecular therapeutics.
Ran
Ningqing
N
BioVerdant, Inc., 7330 Carroll Road, San Diego, CA 92121, USA.
Rui
Eugene
E
Liu
Jinhua
J
Tao
Junhua
J
D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D000924:Anticholesteremic Agents / Q000138:chemical synthesis; D000928:Antidepressive Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D055162:Biocatalysis; D001702:Biopharmaceutics; D001709:Biotechnology; D015195:Drug Design; D004798:Enzymes; D006801:Humans; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*; D015202:Protein Engineering / Q000379:methods*
D000900:Anti-Bacterial Agents; D000924:Anticholesteremic Agents; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; D004798:Enzymes; D004364:Pharmaceutical Preparations