An expedited palliative radiation protocol for lytic or proliferative lesions of appendicular bone in dogs.
Fifty-eight dogs with lytic or proliferative bone lesions were treated with a radiation protocol of two 8-Gy fractions over 2 consecutive days. The protocol was well tolerated, with no increase in early or late effects over previously published protocols. Forty-three (91%) of 47 dogs responded positively to radiation, with a median time of 2 days to onset of pain relief. Median duration of pain relief was 67 days (range 12 to 503 days; mean 99+/-16 days). Median survival time for all dogs was 136 days (mean 179+/-18 days). Distal radial location was a positive prognostic indicator for survival (P=0.005).
Knapp-Hoch
Heather M
HM
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, New York 14853, USA.
Fidel
Janean Louise
JL
Sellon
Rance K
RK
Gavin
Patrick R
PR
D000818:Animals; D001859:Bone Neoplasms / Q000150:complications / Q000532:radiotherapy / Q000662:veterinary*; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D005260:Female; D053208:Kaplan-Meier Estimate; D008297:Male; D012516:Osteosarcoma / Q000150:complications / Q000532:radiotherapy / Q000662:veterinary*; D010146:Pain / Q000209:etiology / Q000532:radiotherapy / Q000662:veterinary; D012189:Retrospective Studies; D016896:Treatment Outcome