title: 'Up and coming' treatments for premature ejaculation: progress towards an approved therapy.
abstract: It is generally accepted that premature ejaculation (PE) is a more common problem than erectile dysfunction, although at present the options currently available for the treatment of PE are limited to behavioural psychotherapy and 'off-label' prescribing of pharmacological therapies. A sexual complaint with such a high prevalence together with an increasing understanding of the psychosocial consequences of PE has naturally stimulated the interest of the pharmaceutical industry and the first products designed specifically for the treatment of PE are either in late-stage clinical development or are already under regulatory review. Most of the new treatments for PE have been developed for 'on-demand' use, which may prove to offer the most favourable risk: benefit profile as well as the flexibility to adapt to differing frequencies of sexual activity. This paper reviews a number of emerging therapies in various stages of development that show potential for use in the treatment of PE.
authors.affiliation: Global Pharma Consulting Ltd, Sandwich, Kent, UK. j.powell@globalpharma.co.uk
authors.forename: J A
authors.initials: JA
authors.lastname: Powell
authors.forename: M G
authors.initials: MG
authors.lastname: Wyllie
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001521:Behavior Therapy; D004542:Ejaculation / Q000187:drug effects*; D006801:Humans; D020902:Hypericum; D007267:Injections; D008297:Male; D010413:Penis; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D008517:Phytotherapy; D011957:Receptors, Opioid / Q000819:agonists; D058825:Serotonin 5-HT1 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
chemical_list: D000779:Anesthetics, Local; D000929:Antidepressive Agents, Tricyclic; D010726:Phosphodiesterase Inhibitors; D011957:Receptors, Opioid; D058825:Serotonin 5-HT1 Receptor Agonists; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors