Immunocorrecting properties of GB-115 dipeptide.
We studied the effects of a new dipeptide with anxiolytic activity (GB-115, N-phenylhexanoyl-glycyl-L-tryptophan amide) on parameters of the immune in intact mice and in animals with secondary immunodeficiency caused by cyclophosphamide. GB-115 in doses of 0.1-10 mg/kg stimulated phagocytic activity of peritoneal macrophages and humoral immune response in intact mice. GB-115 exhibited immunocorrecting activity in animals with secondary immunodeficiency.
Shipaeva
E V
EV
V. V. Zakusov Institute of Pharmacology, Moscow.
Kovalenko
L P
LP
Khaidukov
S V
SV
Kolik
L G
LG
Gudasheva
T A
TA
Durnev
A D
AD
Seredenin
S B
SB
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D016516:CD4-CD8 Ratio; D003520:Cyclophosphamide / Q000633:toxicity; D004151:Dipeptides / Q000008:administration & dosage / Q000494:pharmacology*; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects
D004151:Dipeptides; C520797:GB-115; D007155:Immunologic Factors; D003520:Cyclophosphamide