Effects of ovariectomy and thyroidectomy on course and outcome of Trichinella spiralis infection in rat.
Physiological hormones modulate immune responses and implicate in associated susceptibilities to infections. To clarify these endocrinological effects, the influence of estrogen and thyroid deficiency, due to ovariectomy and thyroidectomy, respectively, on course and outcome of Trichinella spiralis infection in rats was studied. While in ovariectomized rats there was significant increase in both adult and muscle larval counts as compared to intact infected rats, in thyroidectomized rats there was a significant increase in larval but not in adult count. Combined ovariectomy and thyroidectomy resulted in significant increase in both adult and larval counts. Serum CPK and blood glucose were significantly elevated in ovariectomized and/or thyroidectomized rats as compared to intact infected one. The deficiency of female sex hormones, and/or thyroid hormones in T. spiralis infected rats affected the host resistance to infection by increasing parasite burden influencing the course and outcome of parasitic infection.
Thabet
Hala S
HS
Department of Parasitology, Faculty of Medicine, Ain-Shams University, Cairo 11566, Egypt. halasobhy@yahoo.com
Thabet
Sahar S
SS
Ali
Nehad M
NM
Ahmed
Naglaa S
NS
D000818:Animals; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood / Q000276:immunology; D007113:Immunity, Innate; D016867:Immunocompromised Host; D007814:Larva; D018482:Muscle, Skeletal / Q000469:parasitology*; D010052:Ovariectomy; D011897:Random Allocation; D051381:Rats; D013963:Thyroid Hormones / Q000097:blood / Q000276:immunology; D013965:Thyroidectomy; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000469:parasitology* / Q000473:pathology*
D012739:Gonadal Steroid Hormones; D013963:Thyroid Hormones