title: Optical coherence tomography (OCT) reveals depth-resolved dynamics during functional brain activation.
abstract: Optical intrinsic signal imaging (OISI) provides two-dimensional, depth-integrated activation maps of brain activity. Optical coherence tomography (OCT) provides depth-resolved, cross-sectional images of functional brain activation. Co-registered OCT and OISI imaging was performed simultaneously on the rat somatosensory cortex through a thinned skull during forepaw electrical stimulation. Fractional signal change measurements made by OCT revealed a functional signal that correlates well with that of the intrinsic hemodynamic signals and provides depth-resolved, layer-specific dynamics in the functional activation patterns indicating retrograde vessel dilation. OCT is a promising a new technology which provides complementary information to OISI for functional neuroimaging.
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Aaron D
authors.initials: AD
authors.lastname: Aguirre
authors.forename: Lana
authors.initials: L
authors.lastname: Ruvinskaya
authors.forename: Anna
authors.initials: A
authors.lastname: Devor
authors.forename: David A
authors.initials: DA
authors.lastname: Boas
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping / Q000379:methods*; D054351:Electrical Synapses; D005552:Forelimb / Q000294:innervation; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation* / Q000379:methods; D008297:Male; D017711:Nonlinear Dynamics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*