Plasma-treated silk fibroin nanofibers for skin regeneration.
Silk fibroin (SF) nanofibers were prepared by electrospinning and treated with plasma in the presence of oxygen or methane gas to modify their surface characteristics. The surface characteristics of the SF nanofibers after plasma treatment were examined using contact angle measurements and XPS analysis. The hydrophilicity of the electrospun SF nanofibers decreased slightly by the CH(4) plasma treatment. On the other hand, the hydrophilicity of the SF nanofibers increased greatly by an O(2) plasma treatment. The O(2)-treated SF nanofibers showed higher cellular activities for both normal human epidermal keratinocytes (NHEK) and fibroblasts (NHEF) than the untreated ones.
Jeong
Lim
L
Department of Advanced Organic Materials and Textile System Engineering, Chungnam National University, Daejeon, Republic of Korea.
Yeo
In-Sung
IS
Kim
Ha Na
HN
Yoon
Young Il
YI
Jang
Da Hyun
DH
Jung
Sung Youn
SY
Min
Byung-Moo
BM
Park
Won Ho
WH
D002448:Cell Adhesion / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002675:Child, Preschool; D004602:Elements; D000078404:Epidermal Cells; D004817:Epidermis / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D005349:Fibroins / Q000494:pharmacology* / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D015603:Keratinocytes / Q000166:cytology / Q000187:drug effects; D008297:Male; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010949:Plasma / Q000737:chemistry*; D012038:Regeneration / Q000187:drug effects*; D047011:Silk / Q000737:chemistry / Q000494:pharmacology* / Q000648:ultrastructure; D012867:Skin / Q000187:drug effects*; D013057:Spectrum Analysis; D013499:Surface Properties / Q000187:drug effects; D013997:Time Factors; D014867:Water
D004602:Elements; D047011:Silk; D014867:Water; D005349:Fibroins