title: Correlation of survival motor neuron expression in leukocytes and spinal cord in spinal muscular atrophy.
abstract: Survival motor neuron (SMN) messenger RNA and protein levels in spinal muscular atrophy (SMA) model mice and in patients with SMA were measured. There was a high correlation between leukocyte and spinal cord SMN expression in SMA model mice and a moderate correlation between leukocyte SMN expression and age of disease onset in patients with SMA.
authors.affiliation: Department of Neurology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Li-Kai
authors.initials: LK
authors.lastname: Tsai
authors.forename: Chih-Chao
authors.initials: CC
authors.lastname: Yang
authors.forename: Chen-Hung
authors.initials: CH
authors.lastname: Ting
authors.forename: Yi-Ning
authors.initials: YN
authors.lastname: Su
authors.forename: Wuh-Liang
authors.initials: WL
authors.lastname: Hwu
authors.forename: Hung
authors.initials: H
authors.lastname: Li
mesh_terms: D000328:Adult; D017668:Age of Onset; D000818:Animals; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D051379:Mice; D009134:Muscular Atrophy, Spinal / Q000145:classification / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055532:SMN Complex Proteins / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D012333:RNA, Messenger; D055532:SMN Complex Proteins