Structural bioinformatics of Vibrio cholerae aminopeptidase A (PepA) monomer.
Aminopeptidase A (PepA) is a metalloexopeptidase found in Vibrio cholerae .It functions as a transcriptional repressor in regulatory cascade that controls virulence gene expression in V. cholerae. It is involved in protein degradation and in the metabolism of biologically active peptides. We proposed a 3D model of PepA based upon the crystal structure of PepA from Escherichia coli (E. coli) with an intention to evaluate the active site of the enzyme and to predict the properties of this enzyme, study of its 3D structure will help in understanding its role in DNA binding.
Lutfullah
Ghosia
G
Center of Biotechnology, University of Peshawar, Peshawar, Pakistan.
Azhar
Noreen
N
Amin
Farhat
F
Khan
Zahid
Z
Azim
M Kamran
MK
Shouqat
Khalida
K
Noor
Sajid
S
Ali
Rizwan
R
D000595:Amino Acid Sequence; D020134:Catalytic Domain; D019295:Computational Biology; D043384:Glutamyl Aminopeptidase / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D014734:Vibrio cholerae / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity
D043384:Glutamyl Aminopeptidase