title: Oedema risk of endotracheal intubation in rabbits with cessation of steroid therapy.
abstract: Rebound oedema of tissues is a well defined complication of cessation of steroid therapy. Tapering of systemic corticosteroid regimens in short course steroid therapy is considered unnecessary in most circumstances in acute exacerbation of chronic obstructive pulmonary diseases, presence of laryngeal rebound edema is obscure in this situation. We studied whether or not laryngeal oedema increases after intubation when intubation is established after cessation of steroid therapy. Thirty-six rabbits were randomly divided into six groups. We administered 1 mg/kg methyl prednisolone intraperitoneally to four steroid groups for ten days. Another group received serum physiologic for ten days and last group was sham control that was intubated only. Rabbits that received steroid therapy were intubated and separated into groups one day, one week, two weeks, and a month after the cessation of steroid therapy. Airway area and percentage of cross sectional area of larynx lumen to their own larynx tissues surrounded by thyroid cartilage and oesophagus were studied by stereological methods. Larynx lumen area of one week steroid group was significantly narrower and percentage of cross sectional area of larynx lumen to their own larynx tissues surrounded by thyroid cartilage and oesophagus was significantly larger than sham control. Rebound oedema forms in larynx with abrupt cessation of steroid therapy in rabbits. Clinical safe time for intubation after abrupt cessation of steroid therapy is also defined with our study. These results suggest that one week after the cessation of steroid therapy may be a hazardous time for tracheal intubation.
authors.affiliation: Department of Anesthesiology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey. drffidan@yahoo.com
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Fidan
authors.forename: Onder
authors.initials: O
authors.lastname: Sahin
authors.forename: Fatma
authors.initials: F
authors.lastname: Fidan
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Ela
authors.forename: Ahmet
authors.initials: A
authors.lastname: Songur
authors.forename: Murat
authors.initials: M
authors.lastname: Yağmurca
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004487:Edema / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D007442:Intubation, Intratracheal / Q000379:methods*; D011239:Prednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D011817:Rabbits; D011897:Random Allocation; D013375:Substance Withdrawal Syndrome / Q000453:epidemiology / Q000209:etiology* / Q000601:surgery
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone