Sepsis-From human organ failure to laminar failure.
The horse with gram negative sepsis is known to be at particular risk of succumbing to laminitis. This review summarizes recent evidence indicating that similar pathologic events relating to inflammatory injury occur in laminar failure in laminitis as occur in organ injury/failure in human sepsis. The discussion also points out some important differences between the laminae and target organs in human sepsis that impact the clinical nature of the disease.
Belknap
J K
JK
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210, United States. belknap.16@osu.edu
Moore
J N
JN
Crouser
E C
EC
D000818:Animals; D005534:Foot Diseases / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D016905:Gram-Negative Bacterial Infections / Q000150:complications / Q000276:immunology / Q000662:veterinary*; D006724:Hoof and Claw; D006734:Horse Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D006736:Horses; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology / Q000662:veterinary; D018805:Sepsis / Q000150:complications / Q000276:immunology / Q000662:veterinary*