title: Nicotine contents in various toothpowders (dant manjans): measurement and safety evaluation.
abstract: The use of tobacco products as dentrifice is prevalent in various parts of India. Among them toothpowder (dant manjan) is very common. These nicotine containing toothpastes/toothpowders are health hazards and is also habit forming. Health experts of India rightly banned use of nicotine containing toothpowder as early as 1992 by making proper legislation. We just made an attempt to verify whether the manufacturers complying the legislation or not. Eight leading brands of toothpowders were analyzed qualitatively by gas chromatography-mass spectrum detector and also quantitatively by gas chromatography-nitrogen phosphorus detector. Our results indicated four brands were found to contain nicotine in the range of 2.53 microg/g to 11.50 mg/g of toothpowder. This finding further confirms that addition of nicotine in dentifrice violates the regulatory norms. Regulatory authorities should give more attention to ensure that all toothpowders are free from nicotine which is also a statutory requirement.
authors.affiliation: Department of Pharmacology, Delhi Institute of Pharmaceutical Sciences and Research, University of Delhi, Pushp Vihar, Sector-3, M.B. Road, New Delhi 110 017, India. shyamagrawal2006@gmail.com
authors.forename: S S
authors.initials: SS
authors.lastname: Agrawal
authors.forename: K
authors.initials: K
authors.lastname: Rajagopal
mesh_terms: D003802:Dentifrices / Q000009:adverse effects / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D007194:India; D009538:Nicotine / Q000032:analysis*
chemical_list: D003802:Dentifrices; D009538:Nicotine