title: Effects of air transportation cause physiological and biochemical changes indicative of stress leading to regulation of chaperone expression levels and corticosterone concentration.
abstract: Laboratory animals generally experience numerous unfamiliar environmental and psychological influences such as noises, temperatures, handling, shaking, and smells during the process of air transportation. To investigate whether stress induced by air transportation affects stress-related factors in animals, the levels of hormone and chaperone protein were measured in several tissues of F344 rats transported for 13 h and not transported. Herein, we conclude that the levels of corticosterone, HSP70, and GRP78 were significantly increased in the transported group compare to not transported group, but they were rapidly restored to the not transported group level after a recovery period of one week. However, the magnitude of induction and restoration levels of these factors varied depending on the tissue type. Thus, these results suggest that air transportation should be considered for the improvement of laboratory animal health and to reduce the incidence of laboratory animal stress.
authors.affiliation: Laboratory Animal Resources Team, National Institute of Toxicological Research, Korean FDA.
authors.forename: SunBo
authors.initials: S
authors.lastname: Shim
authors.forename: SeHyun
authors.initials: S
authors.lastname: Lee
authors.forename: ChuelKyu
authors.initials: C
authors.lastname: Kim
authors.forename: ByoungGuk
authors.initials: B
authors.lastname: Kim
authors.forename: SeungWan
authors.initials: S
authors.lastname: Jee
authors.forename: SuHae
authors.initials: S
authors.lastname: Lee
authors.forename: JiSoon
authors.initials: J
authors.lastname: Sin
authors.forename: ChangJoon
authors.initials: C
authors.lastname: Bae
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Woo
authors.forename: JungSik
authors.initials: J
authors.lastname: Cho
authors.forename: EonPil
authors.initials: E
authors.lastname: Lee
authors.forename: HaeWook
authors.initials: H
authors.lastname: Choi
authors.forename: HongSung
authors.initials: H
authors.lastname: Kim
authors.forename: JaeHo
authors.initials: J
authors.lastname: Lee
authors.forename: YoungJin
authors.initials: Y
authors.lastname: Jung
authors.forename: ByungWook
authors.initials: B
authors.lastname: Cho
authors.forename: KabRyong
authors.initials: K
authors.lastname: Chae
authors.forename: DaeYoun
authors.initials: D
authors.lastname: Hwang
mesh_terms: D000337:Aerospace Medicine; D000401:Aircraft; D000818:Animals; D001522:Behavior, Animal; D003345:Corticosterone / Q000097:blood*; D000091342:Endoplasmic Reticulum Chaperone BiP; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006360:Heat-Shock Proteins / Q000097:blood*; D008297:Male; D018832:Molecular Chaperones / Q000097:blood*; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors; D013315:Stress, Psychological / Q000097:blood* / Q000209:etiology
chemical_list: D000091342:Endoplasmic Reticulum Chaperone BiP; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D003345:Corticosterone