[New development in bisphosphonate treatment. Bisphosphonates for the treatment of glucocorticoid-induced osteoporosis].
Only bisphosphonates were shown to decrease the risk of vertebral fractures in patients taking glucocorticoids. Relative risk at 1 year treatment with bisphosphonates for incident vertebral fractures and non-vertebral fractures were 0.46 (95% confidence interval : 0.28 - 0.77) and 0.77 (95% confidence interval : 0.39 - 1.51) , respectively. Two years extension of the alendronate trial showed that relative risk for incident vertebral fractures was 0.10 (95% confidence interval : 0.01 - 0.90) .
Soen
Satoshi
S
Kinki University School of Medicine, Nara Hospital, Department of Orthopaedic Surgery and Rheumatology, Japan.
D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D004164:Diphosphonates / Q000627:therapeutic use*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D015201:Meta-Analysis as Topic; D010024:Osteoporosis / Q000139:chemically induced* / Q000150:complications / Q000188:drug therapy*; D016032:Randomized Controlled Trials as Topic; D012306:Risk; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D005938:Glucocorticoids