title: New amide derivatives as melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity.
abstract: Melanin-concentrating hormone (MCH) is a recently discovered central nervous system (CNS) target for treating obesity. Two novel series of amide derivatives were synthesized and evaluated biologically as MCH-R1 (melanin-concentrating hormone receptor 1) antagonists. The results showed that diphenyl substituents on the amide lead to better activity than biphenyl substituents.
authors.affiliation: Unidad de Investigación y Desarrollo de Medicamentos, Centro de Investigación en Farmacobiología Aplicada (CIFA), University of Navarra, Pamplona, Spain.
authors.forename: Nuria
authors.initials: N
authors.lastname: Cirauqui
authors.forename: Javier
authors.initials: J
authors.lastname: Ceras
authors.forename: Silvia
authors.initials: S
authors.lastname: Galiano
authors.forename: Silvia
authors.initials: S
authors.lastname: Pérez-Silanes
authors.forename: Laura
authors.initials: L
authors.lastname: Juanenea
authors.forename: Gildardo
authors.initials: G
authors.lastname: Rivera
authors.forename: Ignacio
authors.initials: I
authors.lastname: Aldana
authors.forename: Antonio
authors.initials: A
authors.lastname: Monge
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D019440:Anti-Obesity Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D007202:Indicators and Reagents; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors*; D012997:Solvents; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D019440:Anti-Obesity Agents; D007202:Indicators and Reagents; C103263:MCHR1 protein, human; D017481:Receptors, Somatostatin; D012997:Solvents