Discovery of 2-(alpha-methylbenzylamino) pyrazines as potent Type II inhibitors of FMS.
A series of 2-(alpha-methylbenzylamino) pyrazines have shown to be potent inhibitors of the FMS tyrosine receptor kinase. Details of SAR studies, modeling and synthesis of compounds within this series are reported.
Burns
Christopher J
CJ
Cytopia Research Pty Ltd, 576 Swan Street, Richmond, VIC. 3121, Australia.
Harte
Michael F
MF
Bu
Xianyong
X
Fantino
Emmanuelle
E
Giarrusso
Marilena
M
Joffe
Max
M
Kurek
Margarita
M
Legge
Fiona S
FS
Razzino
Pasquale
P
Su
Stephen
S
Treutlein
Herbert
H
Wan
Soo San
SS
Zeng
Jun
J
Wilks
Andrew F
AF
D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D008958:Models, Molecular; D015394:Molecular Structure; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D011719:Pyrazines; D016186:Receptor, Macrophage Colony-Stimulating Factor