Inhibition of function of T cell subpopulations and decrease in cytokine production during subacute poisoning with various toxicants.
Experiments on outbred albino rats showed that subacute intoxication with organophosphorus compounds dimethyldichlorovinyl phosphate and malathion primarily decreased functional activity of Th1 lymphocytes, immune reactions associated with these cells, and interferon-g production compared to that of Th2 lymphocytes and interleukin-4 synthesis. Acrylic acid nitrile and methanol produced the opposite effect. Sulfur mustard and sodium arsenite were equally potent in reducing the function of Th1 and Th2 lymphocytes and production of cytokines.
Zabrodskii
P F
PF
Saratov Military Institute of Radiational, Chemical, and Biological Protection, Russia. pz@renet.con.ru
Germanchuk
V G
VG
Mandych
V G
VG
D000179:Acrylates / Q000506:poisoning; D000818:Animals; D018053:Arsenites / Q000506:poisoning; D004006:Dichlorvos / Q000506:poisoning; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007371:Interferon-gamma / Q000097:blood / Q000378:metabolism*; D015847:Interleukin-4 / Q000097:blood / Q000378:metabolism*; D008294:Malathion / Q000506:poisoning; D008297:Male; D000432:Methanol / Q000506:poisoning; D009151:Mustard Gas / Q000506:poisoning; D009570:Nitriles / Q000506:poisoning; D062025:Organophosphate Poisoning; D051381:Rats; D017670:Sodium Compounds / Q000506:poisoning; D018417:Th1 Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D018418:Th2 Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism
D000179:Acrylates; D018053:Arsenites; D009570:Nitriles; D017670:Sodium Compounds; D015847:Interleukin-4; C017947:sodium arsenite; D004006:Dichlorvos; D007371:Interferon-gamma; C036658:acrylic acid; D009151:Mustard Gas; D008294:Malathion; D000432:Methanol