Proceedings of the international consensus conference on breast cancer risk, genetics, & risk management, April, 2007.
A consensus conference including thirty experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from breast cancer "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference being devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general populations was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazic Jews and other founder groups. Risk reduction strategies for these individuals include surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, i.e., bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each of the risk categories. These guidelines for patient care were approved by the entire group of experts.
Schwartz
Gordon F
GF
Jefferson Medical College, 1015 Chestnut Street, Suite 510, Philadelphia, PA 19107-4305, USA. gordonschwartz@yahoo.com
Hughes
Kevin S
KS
Lynch
Henry T
HT
Fabian
Carol J
CJ
Fentiman
Ian S
IS
Robson
Mark E
ME
Domchek
Susan M
SM
Hartmann
Lynn C
LC
Holland
Roland
R
Winchester
David J
DJ
Anderson
Benjamin O
BO
Arun
Banu K
BK
Bartelink
Harry
H
Bernard
Philip
P
Bonanni
Bernardo
B
Cady
Blake
B
Clough
Krishna B
KB
Feig
Stephen A
SA
Heywang-Köbrunner
Sylvia H
SH
Howell
Anthony
A
Isaacs
Claudine
C
Kopans
Daniel B
DB
Mansel
Robert E
RE
Masood
Shahla
S
Palazzo
Juan P
JP
Pressman
Peter I
PI
Solin
Lawrence J
LJ
Untch
Michael
M
D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D016158:Genes, p53; D005817:Genetic Counseling; D006801:Humans; D009154:Mutation; D051059:PTEN Phosphohydrolase / Q000235:genetics; D012307:Risk Factors; D012308:Risk Management
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human