Effect of FX dialysers on systemic inflammation and quality of life in chronic haemodialysis patients.
BACKGROUND
The FX class of haemodialysers features a new class of high-flux polysulfone membrane which has been suggested to induce less inflammation.


METHODS
This was a randomized, cross-over study performed on 33 haemodialysis patients. Patients were randomized to FX60 or HF80 dialysers for 3 months and then changed to the other dialyser. Interleukin-6 (IL-6), tumour necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) were measured at baseline, and every 3 months. The Kidney Disease Quality of Life Short Form was also administered.


RESULTS
The mean of the difference in the IL-6 level between dialysers was 1.4 +/- 8.0 pg/ml (95% CI -1.8, 4.5 pg/ml). There was no significant difference in TNF-alpha (95% CI -0.35, 0.18 pg/ml) or CRP levels (95% CI -2.67, 6.20 mg/l). The quality of social interaction and role limitations caused by physical health problems were significantly higher with the FX60, p = 0.04 and 0.047, respectively.


CONCLUSIONS
The FX dialysers do not result in a significant difference in the level of systemic inflammation compared to the HF80.
Boudville
Neil
N
School of Medicine and Pharmacology, University of Western Australia, W.A., Australia. nboudvil@cyllene.uwa.edu.au
Horner
Marilyn
M
McEwan
Elizabeth
E
Lim
Wai H
WH
Mudge
David W
DW
Markus
Hadley E
HE
D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D018592:Cross-Over Studies; D000068256:Darbepoetin alfa; D000068817:Epoetin Alfa; D004921:Erythropoietin / Q000008:administration & dosage / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D015850:Interleukin-6 / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D011994:Recombinant Proteins; D006435:Renal Dialysis / Q000295:instrumentation* / Q000523:psychology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D015850:Interleukin-6; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D004921:Erythropoietin; D000068256:Darbepoetin alfa; D000068817:Epoetin Alfa; D002097:C-Reactive Protein