title: [Spectrum, clinical features, diagnosis of opportunistic and comorbid pathology in HIV-infected patients admitted to infection hospital of Moscow].
abstract: OBJECTIVE
  To analyse structure, clinical features, diagnosis of opportunistic and concomitant diseases in patients with HIV infection admitted to infection hospital of Moscow.
  
  
  METHODS
  A total of 4155 patients with HIV infection (1518 of them with AIDS) most of them (89%) at the age of 20-39 years were treated in Moscow AIDS hospital in 2006-2007. The examination included standard blood and urine tests, device diagnosis, immunological, bacteriological and molecular investigations of biological materials for detection of opportunistic infections. Cell-mediated immunity was also studied. HIV infection resulted in a lethal outcome in 255 (6.1%) inpatients.
  
  
  RESULTS
  Leading causes of hospitalization of patients at early stages of HIV infection were bacterial bronchitis or pneumonia, hepatic pathology (chronic viral hepatitides, alcohol-associated diseases), sepsis. One-third of the inpatients were at AIDS stage characterized by tuberculosis (66.3%), visceral candidosis (12%), manifest cytomegalovirus infection (10.1%), cerebral toxoplasmosis (9.2%), pneumocystic pneumonia (5.5%). The number of HIV-infected persons with atypical mycobacteriosis, lymphoproliferative diseases, brain tumors increased. Chronic hepatitis C prevailed among liver damage cause in HIV infection, it also often caused hospitalization and death of patients. 60.3% patients having HIV infection who died without AIDS stage had hepatic cirrhosis. Tuberculosis was a leading cause of severe pulmonary pathology, most frequent opportunistic disease, main cause of death in patients with HIV infection. One-third of patients had generalized tuberculosis. Tuberculosis was diagnosed in more than 40% HIV-infected patients with pulmonary lesion, in 65% AIDS patients, 36% dead AIDS patients.
  
  
  CONCLUSIONS
  To render effective anti-HIV treatment, infection hospital must be equipped with facilities providing device tests, molecular diagnosis, modern etiotropic and pathogenetic medication.
authors.forename: V I
authors.initials: VI
authors.lastname: Shakhgil'dian
authors.forename: T E
authors.initials: TE
authors.lastname: Vasil'eva
authors.forename: A B
authors.initials: AB
authors.lastname: Peregudova
authors.forename: B M
authors.initials: BM
authors.lastname: Gruzdev
authors.forename: T V
authors.initials: TV
authors.lastname: Danilova
authors.forename: n N
authors.initials: nN
authors.lastname: Martynova
authors.forename: P G
authors.initials: PG
authors.lastname: Filippov
authors.forename: N G
authors.initials: NG
authors.lastname: Litvinova
authors.forename: l E
authors.initials: lE
authors.lastname: Pavlova
authors.forename: O A
authors.initials: OA
authors.lastname: Tishkevich
authors.forename: M V
authors.initials: MV
authors.lastname: Iuditskiĭ
authors.forename: A Ia
authors.initials: AIa
authors.lastname: Ol'shanskiĭ
authors.forename: A I
authors.initials: AI
authors.lastname: Mazus
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000534:rehabilitation; D000328:Adult; D002391:Catchment Area, Health; D015897:Comorbidity; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000453:epidemiology / Q000534:rehabilitation; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology / Q000534:rehabilitation; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D009894:Opportunistic Infections / Q000175:diagnosis / Q000453:epidemiology / Q000534:rehabilitation; D010343:Patient Admission / Q000706:statistics & numerical data*; D012426:Russia / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology / Q000534:rehabilitation; D055815:Young Adult