Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism.
OBJECTIVE
To compared the plasma levels and the genetic polymorphism of myeloperoxidase in patients with pelvic inflammatory disease (PID) and healthy controls.


METHODS
A random consecutive study.


METHODS
University hospital.


METHODS
Forty-four women who were diagnosed with PID.


METHODS
Collected blood specimens of patients before and after they received treatment.


METHODS
ELISA and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma levels and genetic polymorphism of myeloperoxidase.


RESULTS
We found the plasma level of myeloperoxidase was elevated in PID patients compared with that in normal controls and decreased significantly compared with that in the same patients after they received treatment. PID patients with myeloperoxidase G/A alleles significantly tended to have elevated plasma concentration of myeloperoxidase, whereas PID patients with G/G homozygous alleles did not.


CONCLUSIONS
Elevated expression of myeloperoxidase may be involved in the pathogenesis of PID and could be useful for the diagnosis of PID. Furthermore, G/A alleles of myeloperoxidase may contribute to such elevation in PID patients.
Lee
Shun-An
SA
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
Wang
Po-Hui
PH
Chiou
Hui-Ling
HL
Chou
Ming-Chin
MC
Tsai
Hsiu-Ting
HT
Yang
Shun-Fa
SF
D000225:Adenine; D000483:Alleles; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D009195:Peroxidase / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
D015415:Biomarkers; D009195:Peroxidase; D000225:Adenine