title: Dose-volume population histogram: a new tool for evaluating plans whilst considering geometrical uncertainties.
abstract: We present a method to incorporate geometrical uncertainties into dose-volume histogram evaluation: the dose-volume population histogram (DVPH). For each dose-volume point, the probability of the plan DVH meeting the constraint is calculated. The use of DVPH for the target shows that the minimum dose to the PTV might not be representative of the minimum dose to the CTV considering geometrical uncertainties when the PTV extends into the build-up region. For OARs, the DVH obtained from DVPH with 90% confidence level is found to be different to the planning organ at risk volume (PRV) DVH recommended by ICRU 62, especially for parallel organs.
authors.affiliation: Medical Physics Department, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.
authors.forename: T B
authors.initials: TB
authors.lastname: Nguyen
authors.forename: A C F
authors.initials: AC
authors.lastname: Hoole
authors.forename: N G
authors.initials: NG
authors.lastname: Burnet
authors.forename: S J
authors.initials: SJ
authors.lastname: Thomas
mesh_terms: D000465:Algorithms; D001822:Body Burden; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D012984:Software