Effects of dietary herring roe lipids on plasma lipid, glucose, insulin, and adiponectin concentrations in mice.
The aim of this study was to evaluate the effects of dietary Kazunoko (salted herring roe) lipids, which contain large amounts of cholesterol, phosphatidylcholine, and n-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), on lipid and glucose metabolism in mice. Male Crlj:CD-1 (ICR) mice were fed one of four experimental diets which contained 6% lard, 1% Kazunoko lipids + 5% lard, 3% Kazunoko lipids + 3% lard, and 6% Kazunoko lipids for 12 weeks. Plasma total cholesterol, triacylglycerol, phospholipid, and glucose concentrations were significantly lower in the 3% and 6% Kazunoko lipid diet groups than in lard and 1% Kazunoko lipid diet groups (p < 0.05). Plasma adiponectin concentrations of mice fed the 6% Kazunoko lipid diet were higher than those of animals fed the lard diet group. These results suggest that EPA and DHA rather than cholesterol in the Kazunoko lipids influence the plasma total cholesterol level. The constituent Kazunoko lipids may not only decrease the levels of plasma lipids but also decrease glucose concentrations by enhancing plasma adiponectin levels in mice.
Higuchi
Tomoyuki
T
National Food Research Institute, 2-1-12, Kannondai, Tsukuba, Ibaraki 305-8642, Japan. higuchi@eiyo.ac.jp
Shirai
Nobuya
N
Suzuki
Hiramitsu
H
D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood; D007328:Insulin / Q000097:blood / Q000378:metabolism; D050356:Lipid Metabolism / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D055442:Metabolome / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D010743:Phospholipids / Q000097:blood / Q000378:metabolism; D017747:Seafood; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D052242:Adiponectin; D001786:Blood Glucose; D004041:Dietary Fats; D005227:Fatty Acids; D007328:Insulin; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol