Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children.
BACKGROUND
Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults.


METHODS
Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured.


RESULTS
Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors.


CONCLUSIONS
Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.
Okahashi
Aya
A
Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
Okada
Tomoo
T
Saito
Emiko
E
Miyashita
Michio
M
Kuromori
Yuki
Y
Iwata
Fujihiko
F
Hara
Mitsuhiko
M
Mugishima
Hideo
H
Kitamura
Yohei
Y
Shimizu
Takashi
T
D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D012307:Risk Factors
D008078:Cholesterol, LDL; D005227:Fatty Acids; C017364:hexacosanoic acid