title: The intracellular localization of ID2 expression has a predictive value in non small cell lung cancer.
abstract: BACKGROUND
  ID2 is a member of a subclass of transcription regulators belonging to the general bHLH (basic-helix-loop-helix) family of transcription factors. In normal cells, ID2 is responsible for regulating the balance between proliferation and differentiation. More recent studies have demonstrated that ID2 is involved in tumor progression in several cancer types such as prostate or breast.
  
  
  RESULTS
  In this work, we investigated, for the first time, the relationship between the expression of ID2 in non-small cell lung cancer (NSCLC) patients and the clinicopathological features and prognosis of these patients. Immunohistochemistry was performed on tissue microarrays, which included 62 NSCLC tumors. In malignant tissues, ID2 expression has been detected in both the nuclear and cytoplasmic compartments, but we have demonstrated that only nuclear expression of ID2 is inversely correlated with the differentiation grade of the tumor (p = 0.007). Interestingly, among patients with poorly differentiated tumors, high nuclear expression of ID2 was an independent and unfavorable prognostic factor for survival (p = 0.036).
  
  
  CONCLUSIONS
  These results suggest that ID2 could be involved in tumor dedifferentiation processes of NSCLC, and could be used as prognostic marker for patients with poorly differentiated tumors.
authors.affiliation: CEA, DSV, IRCM, Laboratoire d'Exploration Fonctionnelle des Génomes, Evry, France.
authors.forename: Jérôme
authors.initials: J
authors.lastname: Rollin
authors.forename: Claire
authors.initials: C
authors.lastname: Bléchet
authors.forename: Sandra
authors.initials: S
authors.lastname: Régina
authors.forename: Arthur
authors.initials: A
authors.lastname: Tenenhaus
authors.forename: Serge
authors.initials: S
authors.lastname: Guyétant
authors.forename: Xavier
authors.initials: X
authors.lastname: Gidrol
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D006801:Humans; D007150:Immunohistochemistry; D051797:Inhibitor of Differentiation Protein 2 / Q000032:analysis* / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D011446:Prospective Studies; D040081:Protein Array Analysis; D014407:Tumor Cells, Cultured
chemical_list: C497450:ID2 protein, human; D051797:Inhibitor of Differentiation Protein 2