title: Active neovascularization and possible vascular-centric development of gastric and periscapular elastofibromas.
abstract: An elastofibroma is a benign and rare fibrous lesion that most commonly occurs in the periscapular region. A gastrointestinal elastofibroma is extremely rare. In the present study, six cases of elastofibromas including a case in the stomach were evaluated. The gastric case revealed widely distributed lesions in the submucosal layer with perivascular fibrotic lesions (PVFLs) and some PVFLs were distributed to the skip lesions of elastofibroma. These PVFLs were also observed in all five periscapular cases and invariably contained elastic fibers which showed various degree of maturation. CD34-positive stromal cells were observed not only in elastofibromas but also in PVFLs in each case. These findings suggested the possibility of the PVFLs were the primary lesions of elastofibroma and their vascular-centric development. The percentage of the CD105-positive vessels in elastofibroma group was significantly higher than in the control group. This result indicates active neovascularization in elastofibromas.
authors.affiliation: Department of Pathology and Biodefense, Saga University Faculty of Medicine, Nabesima 5-1-1, Saga city, Saga, 849-8501, Japan. kaikeit@cc.saga-u.ac.jp
authors.forename: Keita
authors.initials: K
authors.lastname: Kai
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Kusano
authors.forename: Masashi
authors.initials: M
authors.lastname: Sakai
authors.forename: Masanobu
authors.initials: M
authors.lastname: Tabuchi
authors.forename: Seiji
authors.initials: S
authors.lastname: Yunotani
authors.forename: Kohji
authors.initials: K
authors.lastname: Miyazaki
authors.forename: Osamu
authors.initials: O
authors.lastname: Tokunaga
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D000071063:Endoglin; D005260:Female; D005350:Fibroma / Q000098:blood supply* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic / Q000473:pathology*; D017346:Protein Serine-Threonine Kinases / Q000032:analysis; D000077294:Receptor, Transforming Growth Factor-beta Type II; D011956:Receptors, Cell Surface / Q000032:analysis; D018125:Receptors, Transforming Growth Factor beta / Q000032:analysis; D012540:Scapula; D013274:Stomach Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000648:ultrastructure; D017154:Stromal Cells / Q000473:pathology; D053773:Transforming Growth Factor beta1 / Q000032:analysis
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D018125:Receptors, Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1; D017346:Protein Serine-Threonine Kinases; D000077294:Receptor, Transforming Growth Factor-beta Type II