title: Harmonic scalpel in pharyngolaryngectomy with radical neck dissection.
abstract: OBJECTIVE
  The aim of this study was to verify the efficacy and applicability of the Ultracision Harmonic Scalpel (Ethicon Endo-Surgery, Cincinnati, OH) in pharyngolaryngectomy with radical neck dissection.
  
  
  METHODS
  This work evaluated the use of the Harmonic Scalpel in otolaryngology as a new and alternative method to overcome some complications of traditional surgery.
  
  
  METHODS
  The study was conducted with 20 patients in the ENT Department of the University of Genoa (Italy) between January 1, 2005, and December 31, 2006.
  
  
  METHODS
  A prospective, randomized study was undertaken on 20 pharyngolaryngectomies with radical neck dissection performed using a Harmonic Scalpel (10 patients) or traditional surgery (10 patients).
  
  
  METHODS
  The evaluation included operation time, intraoperative blood loss, postoperative seroma formation, and pattern of wound healing.
  
  
  RESULTS
  In patients treated with Harmonic Scalpel, the mean operation time was significantly shorter, the blood loss was less, laryngeal and neck drainage on the first and second postoperative days was significantly smaller, and no postoperative complications were noted.
  
  
  CONCLUSIONS
  The use of the Harmonic Scalpel during pharyngolaryngectomy and radical neck dissection led to diminished bleeding, shorter operative time, less seroma formation, and better wound healing in the postoperative period.
authors.affiliation: ENT Department, University of Genoa, Genoa, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Salami
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bavazzano
authors.forename: Renzo
authors.initials: R
authors.lastname: Mora
authors.forename: Massimo
authors.initials: M
authors.lastname: Dellepiane
mesh_terms: D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical / Q000503:physiopathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D004322:Drainage / Q000706:statistics & numerical data; D004869:Equipment Safety; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery; D007825:Laryngectomy / Q000295:instrumentation* / Q000379:methods; D053685:Laser Therapy; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection / Q000295:instrumentation* / Q000379:methods; D009367:Neoplasm Staging; D010149:Postoperative Pain / Q000503:physiopathology; D010610:Pharyngeal Neoplasms / Q000473:pathology / Q000601:surgery; D010611:Pharyngectomy / Q000295:instrumentation* / Q000379:methods; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D013525:Surgical Instruments; D013997:Time Factors; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology