title: Infection outcomes in splenectomized patients with hemoglobinopathies in Australia.
abstract: OBJECTIVE
  To assess the infection risk of splenectomized persons with hemoglobinopathies in Australia.
  
  
  METHODS
  This was an Australia cohort study of infections and vaccinations in 63 patients with hemoglobinopathies followed longitudinally from 1967 to 2006, and an investigation into the risk factors for poor outcome.
  
  
  RESULTS
  There were 28 cases of bacterial infection that necessitated hospitalization in the cohort, resulting in an incidence of 1.4 bacterial infections per 100 patient-years. There was one death (1.6%) as a direct result of bacterial infection. Hepatitis C was diagnosed in 28 patients (44%). The spectrum of infection included pneumonia (6/28), cellulitis (6/28), bacteremia (4/28), and skin abscess (3/28). Notably, Klebsiella species organisms were isolated in 9/28 cultures.
  
  
  CONCLUSIONS
  Infectious complications in this group of patients cause serious morbidity and mortality. This cohort may be a target for novel preventive strategies such as more immunogenic vaccines, patient registries, and/or education programs.
authors.affiliation: Centre for Clinical Research Excellence-Infection and Bioethics in Haematological Malignancies Level 3, ICPMR, Westmead Hospital, Institute Road, Westmead, NSW 2145, Australia. alvin.yapp@gmail.com
authors.forename: Alvin R
authors.initials: AR
authors.lastname: Yapp
authors.forename: Robert
authors.initials: R
authors.lastname: Lindeman
authors.forename: Nicole
authors.initials: N
authors.lastname: Gilroy
authors.forename: Zhanhai
authors.initials: Z
authors.lastname: Gao
authors.forename: C Raina
authors.initials: CR
authors.lastname: Macintyre
mesh_terms: D000293:Adolescent; D000328:Adult; D001315:Australia / Q000453:epidemiology; D001424:Bacterial Infections / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality / Q000503:physiopathology; D017848:Blood-Borne Pathogens; D015331:Cohort Studies; D006453:Hemoglobinopathies / Q000145:classification / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D013156:Splenectomy / Q000009:adverse effects*; D015996:Survival Rate; D013789:Thalassemia / Q000150:complications; D014777:Virus Diseases / Q000453:epidemiology / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D055815:Young Adult