title: Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion.
abstract: OBJECTIVE
  To investigate the association of vascular endothelial growth factor (VEGF) polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) with idiopathic recurrent spontaneous abortion (RSA) in Koreans.
  
  
  METHODS
  Prospective case-control study.
  
  
  METHODS
  University-based hospital.
  
  
  METHODS
  Two hundred and fifteen patients with a history of two or more unexplained consecutive pregnancy losses and 113 healthy controls with at least one live birth and no history of pregnancy loss.
  
  
  METHODS
  None.
  
  
  METHODS
  Polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses were performed for the -2578C>A and 936C>T genotypes. Real-time PCR was also used to analyze the -1154G>A and -634G>C genotypes.
  
  
  RESULTS
  The GA (adjusted odds ratio [AOR] 2.774; 95% confidence interval [CI] 1.512-5.092) genotype of the VEGF -1154G>A polymorphism was significantly different between women with idiopathic RSA and controls. The difference in overall (GA + AA) frequency was also marginally significant between the controls and patients with idiopathic RSA (AOR, 2.006; 95% CI, 1.158-3.473). The differences in frequencies of the A-A-G-T and C-A-G-T haplotypes of the VEGF polymorphisms (-2578C>A, -1154G>A, -634G>C, 936C>T) were marginally significant between the patient and control groups.
  
  
  CONCLUSIONS
  This study suggests that VEGF polymorphisms and haplotypes are a genetic determinant for the risk of idiopathic RSA in Korean women.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Pochon CHA University, Seongnam, South Korea.
authors.forename: Hyun Haing
authors.initials: HH
authors.lastname: Lee
authors.forename: Seung Ho
authors.initials: SH
authors.lastname: Hong
authors.forename: Seung Ju
authors.initials: SJ
authors.lastname: Shin
authors.forename: Jung Jae
authors.initials: JJ
authors.lastname: Ko
authors.forename: Doyeun
authors.initials: D
authors.lastname: Oh
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies / Q000379:methods; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007723:Korea / Q000453:epidemiology; D011110:Polymorphism, Genetic / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*; D055815:Young Adult
chemical_list: D042461:Vascular Endothelial Growth Factor A