Thermodynamics of G x A mispairs in DNA: continuum electrostatic model.
An analysis of the stability of a duplex containing G x A mispairs or G x A/A x G tandem during the DNA melting has shown that the duplex stability depends on both DNA sequences and the conformations of the G x A mispairs. The thermodynamics of single pair opening for the G(anti) x A(syn) and G(anti) x A(anti) conformations adopted by a G x A mispair is found to strongly correlate with that of the canonical base pairs, while for the sheared conformation a significant difference is observed.
Berashevich
Julia
J
Department of Physics and Astronomy, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
Chakraborty
Tapash
T
D000225:Adenine; D020137:Base Pair Mismatch; D004247:DNA / Q000737:chemistry*; D006147:Guanine; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D055672:Static Electricity; D013816:Thermodynamics
D006147:Guanine; D004247:DNA; D000225:Adenine