Synthesis of unprecedented scaffold diversity.
Building a better library: The synthesis of a library of natural-product-like small molecules with unprecedented scaffold diversity has been reported (see scheme; Ns = nosylate). The library represents a significant advancement in the capability of synthetic chemists to generate structurally diverse and complex small molecules in a rapid manner.
Galloway
Warren R J D
WR
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Diáz-Gavilán
Mónica
M
Isidro-Llobet
Albert
A
Spring
David R
DR
D001685:Biological Factors / Q000138:chemical synthesis / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D054852:Small Molecule Libraries
D001685:Biological Factors; D054852:Small Molecule Libraries