Mortality risk in hemodialysis patients with increased arterial stiffness is reduced by attainment of classical clinical performance measures.
BACKGROUND
We determined whether attainment of classical clinical performance measures for hemodialysis care improves survival in hemodialysis patients with increased arterial stiffness.


METHODS
We performed a prospective cohort study of 538 hemodialysis patients with a median follow-up of 19 months (interquartile range 8-30). Arterial stiffness was measured using applanation tonometry. Clinical performance measure targets were hemoglobin value >or=110 g/l, serum albumin value >or=37 g/l and measured single-pool Kt/V urea value >or=1.2.


RESULTS
During follow-up, 217 patients (40%) died. In non-survivors, arterial stiffness of large arteries (S1) was significantly higher compared with survivors (p = 0.0002). An analysis of hemodialysis patients who were alive 18 months after inclusion into the study showed that survival was significantly longer in those patients that met >or=2 clinical performance measure targets compared with patients that met <or=1 target (chi(2) 4.13; p = 0.04). Better attainment of classical clinical performance measures showed a 54% mortality risk reduction.


CONCLUSIONS
S1 predicted mortality in hemodialysis patients. However, better attainment of classical clinical performance measures significantly improved long-term outcome in hemodialysis patients despite their pronounced increase in arterial stiffness.
Scholze
Alexandra
A
Medizinische Klinik, Nephrologie, Charité Campus Benjamin Franklin, Berlin, Germany.
Thies
Christina
C
Cheikhalfraj
Mohamed
M
Wittstock
Antje
A
Pommer
Wolfgang
W
Zidek
Walter
W
Tepel
Martin
M
D000368:Aged; D000418:Albumins / Q000378:metabolism; D004548:Elasticity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D053208:Kaplan-Meier Estimate; D007676:Kidney Failure, Chronic / Q000097:blood / Q000401:mortality* / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011446:Prospective Studies; D017534:Radial Artery / Q000503:physiopathology*; D006435:Renal Dialysis / Q000592:standards*; D012307:Risk Factors
D000418:Albumins; D006454:Hemoglobins