title: Caudal epidural sufentanil and bupivacaine decreases stress response in paediatric cardiac surgery.
abstract: Surgery and anaesthesia are known to cause stress response. Attenuation of stress response can decrease morbidity, postoperative hospital length of stay and, thus, cost. Intrathecal and epidural techniques produce reliable analgesia in patients undergoing surgery along with stress response attenuation. The present study was undertaken to evaluate the efficacy of caudal sufentanil and bupivacaine combination on perioperative stress response in paediatric patients undergoing open heart surgery. Thirty patients (ASA grade II-III) undergoing elective corrective cardiac surgery for acyanotic congenital heart disease, were randomly allocated to two groups. In group GA (n = 15), patients received balanced general anaesthesia. In group GC (n = 15), in addition to general anaesthesia, caudal block with bupivacaine and sufentanil combination was given after endotracheal intubation. Monitoring included electrocardiography, invasive arterial pressure, end-tidal carbon dioxide, pulse oximetry, arterial blood gases including serum electrolytes, blood glucose, serum cortisol, urine output, central venous pressure and temperature. Haemodynamic responses in both groups were statistically similar. Serum cortisol levels were significantly lower in GC group than GA group (P < 0.05) after sternotomy (9.8+/-7.5 vs. 34.74+/-27.35), on cardiopulmonary bypass (CPB) (12.17 +/- 6.2 vs. 35.36 +/- 24.15), after sternal closure (14.03 +/- 5.1 vs. 37.62 +/- 20.69), 4 hours (26.64 +/- 14.61 vs. 37.62 +/- 9.13) and 24 hours (14.30 +/- 8.11 vs. 28.12 +/- 16.31) after intubation. Blood glucose levels were significantly higher in GA group as compared to GC group at sternal closure (277.46 +/- 77.25 vs.197.73 +/- 42.17) and 4 hours (255.26 +/- 73.73 vs. 185.26 +/- 57.41) after intubation (P < 0.05). To conclude, supplementation of caudal epidural bupivacaine and sufentanil could effectively attenuate the stress response in paediatric patients undergoing cardiac surgery under CPB in acyanotic congenital heart anomaly.
authors.affiliation: Department of Cardiac Anaesthesia, Cardiothoracic Centre, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India.
authors.forename: Chaitali
authors.initials: C
authors.lastname: Sendasgupta
authors.forename: Neeti
authors.initials: N
authors.lastname: Makhija
authors.forename: Usha
authors.initials: U
authors.lastname: Kiran
authors.forename: Shiv K
authors.initials: SK
authors.lastname: Choudhary
authors.forename: R
authors.initials: R
authors.lastname: Lakshmy
authors.forename: Sambhu N
authors.initials: SN
authors.lastname: Das
mesh_terms: D000763:Anesthesia, Caudal / Q000379:methods; D000767:Anesthesia, Epidural / Q000379:methods; D000768:Anesthesia, General / Q000379:methods; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis*; D002045:Bupivacaine / Q000494:pharmacology*; D006348:Cardiac Surgical Procedures / Q000379:methods; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D017409:Sufentanil / Q000494:pharmacology*; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D001786:Blood Glucose; D017409:Sufentanil; D006854:Hydrocortisone; D002045:Bupivacaine