Antibiofilm activity of a diverse oroidin library generated through reductive acylation.
A diverse 20-compound library of analogues based on the marine alkaloid oroidin were synthesized via a reductive acylation strategy. The final target was then assayed for inhibition and dispersion activity against common proteobacteria known to form biofilms. This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues.
Ballard
T Eric
TE
Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, USA.
Richards
Justin J
JJ
Aquino
Arianexys
A
Reed
Catherine S
CS
Melander
Christian
C
D000215:Acylation; D018441:Biofilms / Q000187:drug effects*; D010084:Oxidation-Reduction; D020560:Proteobacteria / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D011758:Pyrroles; D054852:Small Molecule Libraries; C077209:oroidin