Pancreatic cancer: translating lessons from mouse models and hereditary syndromes.
Pancreatic ductal adenocarcinoma is the overwhelmingly predominant form of pancreatic cancer and the second most common type of gastrointestinal cancer (behind colorectal cancer) in the United States. Recent exciting advances in two areas of pancreatic ductal adenocarcinoma (i.e., the development and characterization of genetically engineered mouse models and the dissection of the genetic basis of hereditary forms in families) have been illuminating. These preclinical models and clinical syndromes provide the first tangible basis for progress in screening and prevention in high-risk populations and in the development of molecular diagnostics and experimental therapeutics.
Wescott
Melanie P
MP
University of Pennsylvania, 600 CRB, 415 Curie Boulevard, Philadelphia, PA 19104, USA.
Rustgi
Anil K
AK
D000818:Animals; D014408:Biomarkers, Tumor / Q000235:genetics; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics* / Q000517:prevention & control; D004195:Disease Models, Animal; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D051379:Mice; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000517:prevention & control; D010195:Pancreatitis / Q000209:etiology
D014408:Biomarkers, Tumor