Effects of synthetic and plant-derived selective modulators of estrogen receptors on depression-like behavior of female rats.
Effects of chronic (for 14 days) intramuscular injections of tamoxifen (10 mg/kg), klimadynon (Cimicifuga extract; 20 mg/kg), and genistein (10 mg/kg) on depression-like state were studied in female rats under conditions of natural fluctuations of blood estrogen levels and ovariectomy. Chronic tamoxifen caused a pronounced depression, while chronic klimadynon and genistein exhibited a pronounced antidepressant effect in intact and ovariectomized rats.
Sapronov
N S
NS
S. V. Anichkov Department of Neuropharmacology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg.
Kasakova
S B
SB
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology; D030762:Estrous Cycle / Q000502:physiology; D005260:Female; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D019833:Genistein / Q000494:pharmacology / Q000627:therapeutic use; D010052:Ovariectomy; D048789:Phytoestrogens / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology / Q000627:therapeutic use; D013629:Tamoxifen / Q000494:pharmacology / Q000627:therapeutic use
D048789:Phytoestrogens; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D019833:Genistein