The primary cilium coordinates signaling pathways in cell cycle control and migration during development and tissue repair.
Cell cycle control and migration are critical processes during development and maintenance of tissue functions. Recently, primary cilia were shown to take part in coordination of the signaling pathways that control these cellular processes in human health and disease. In this review, we present an overview of the function of primary cilia and the centrosome in the signaling pathways that regulate cell cycle control and migration with focus on ciliary signaling via platelet-derived growth factor receptor alpha (PDGFRalpha). We also consider how the primary cilium and the centrosome interact with the extracellular matrix, coordinate Wnt signaling, and modulate cytoskeletal changes that impinge on both cell cycle control and cell migration.
Christensen
Søren T
ST
Department of Biology, Section of Cell and Developmental Biology, The August Krogh Building, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen OE, Denmark.
Pedersen
Stine F
SF
Satir
Peter
P
Veland
Iben R
IR
Schneider
Linda
L
D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002465:Cell Movement; D002923:Cilia / Q000502:physiology*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000378:metabolism; D012038:Regeneration; D015398:Signal Transduction / Q000502:physiology*; D023822:Tissue Engineering
D020796:Receptor, Platelet-Derived Growth Factor alpha