[Serious adverse events derived from the drug interactions of antiretroviral therapy].
OBJECTIVE
Antiretroviral drugs can cause drug interactions.


METHODS
Three clinical cases are described regarding HIV-infected patients in which a clinically relevant adverse effect occurred due to a pharmacokinetic interaction.


RESULTS
Case 1: A 43-year old woman being treated with tenofovir DF, emtricitabine and lopinavir/ritonavir who presents ischemia in both upper extremities following an ergotamine syndrome. Case 2: A 54-year old man being treated with zidovudine, lamivudine and lopinavir/ritonavir who presents Cushing syndrome following to use of inhaled fluticasone. Case 3: A 45-year old man being treated with tenofovir DF, emtricitabine and atazanavir/ritonavir who presents a virological failure as consequence of concomitant use of omeprazole.


CONCLUSIONS
Potential drug interactions must be considered when other concomitant drugs are used with antiretroviral therapy especially when one of these is a P 450 cytochrome enzymatic inductor or inhibitor.
Morales Conejo
M
M
Servicio de Medicina Interna, Hospital de Móstoles, Madrid, España.
Moreno Cuerda
V J
VJ
Abellán Martínez
J
J
Rubio
R
R
D000328:Adult; D044966:Anti-Retroviral Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged
D044966:Anti-Retroviral Agents; D003577:Cytochrome P-450 Enzyme System