title: Tetrahydrofuran acetogenins from Laurencia glandulifera.
abstract: Five new C(15) acetogenin en-ynes (1-5) with a rare tetrahydrofuran moiety and a linear biosynthetic precursor (6) were isolated from an organic extract of Laurencia glandulifera, collected from the island of Crete in the south Aegean Sea. The structures of the new natural products, as well as their relative configuration, were established by means of spectroscopic data analysis. The cytotoxicity of the isolated natural products was evaluated against five human tumor cell lines.
authors.affiliation: Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
authors.forename: Maria
authors.initials: M
authors.lastname: Kladi
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: Panagiota
authors.initials: P
authors.lastname: Papazafiri
authors.forename: Simone
authors.initials: S
authors.lastname: Brogi
authors.forename: Andrea
authors.initials: A
authors.lastname: Tafi
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
mesh_terms: D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006115:Greece; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D054378:Acetogenins; D000480:Alkynes; D005663:Furans; C018674:tetrahydrofuran