Effects of various vehicles on skin hydration in vivo.
The stratum corneum, the outermost layer of the skin, regulates the passive loss of water to the environment. Furthermore, it is well accepted that drug penetration is influenced by skin hydration, which may be manipulated by the application of moisturizing or oleaginous vehicles. Measurements of transepidermal water loss (TEWL), and of skin hydration using a corneometer, were used to assess the effect of different vehicles on stratum corneum barrier function in vivo in human volunteers. A microemulsion significantly increased skin hydration relative to a reference vehicle based on medium chain triglycerides; in contrast, Transcutol(R) lowered skin hydration. TEWL measurements confirmed these observations.
Wiedersberg
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S
Department of Pharmacy and Pharmacology, University of Bath, Bath, UK. sandra.wiedersberg@ltslohmann.de
Leopold
C S
CS
Guy
R H
RH
D000328:Adult; D001682:Biological Availability; D003879:Dermatologic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D005260:Female; D006801:Humans; D014677:Pharmaceutical Vehicles; D010865:Pilot Projects; D012867:Skin / Q000737:chemistry / Q000378:metabolism*; D014867:Water / Q000737:chemistry; D014870:Water Loss, Insensible; D055815:Young Adult
D003879:Dermatologic Agents; D004655:Emulsions; D014677:Pharmaceutical Vehicles; D014867:Water