Hypocholesterolemic effect of peanut skin and its fractions: a case record of rats fed on a high-cholesterol diet.
Peanut skin (PS) is characterized by almost exclusively consisting of polyphenols and fiber. We fractionated PS into a water-soluble fraction (WSF) and water-insoluble fraction (WIF), and further fractionated WSF into a soluble dietary fiber fraction (DF) and dietary fiber-free, water-soluble fraction (DFF-WSF). Male Sprague-Dawley rats were fed on high-cholesterol diets supplemented with PS and its fractions. PS, WSF, and DFF-WSF decreased the serum lipid and cholesterol levels and increased those in feces. This effect was probably due to the polyphenols that inhibited intestinal cholesterol absorption.
Shimizu-Ibuka
Akiko
A
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
Udagawa
Haruhide
H
Kobayashi-Hattori
Kazuo
K
Mura
Kiyoshi
K
Tokue
Chiyoko
C
Takita
Toshichika
T
Arai
Soichi
S
D000818:Animals; D000924:Anticholesteremic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D010367:Arachis / Q000737:chemistry*; D005591:Chemical Fractionation; D002784:Cholesterol / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D004032:Diet; D005243:Feces / Q000737:chemistry; D005419:Flavonoids / Q000494:pharmacology; D007408:Intestinal Absorption; D008055:Lipids / Q000032:analysis / Q000097:blood; D008297:Male; D010636:Phenols / Q000494:pharmacology; D059808:Polyphenols; D051381:Rats; D017207:Rats, Sprague-Dawley
D000924:Anticholesteremic Agents; D005419:Flavonoids; D008055:Lipids; D010636:Phenols; D059808:Polyphenols; D002784:Cholesterol