title: Inhibition of cancer cell growth by ruthenium(II) cyclopentadienyl derivative complexes with heteroaromatic ligands.
abstract: Inhibition of the growth of LoVo human colon adenocarcinoma and MiaPaCa pancreatic cancer cell lines by two new organometallic ruthenium(II) complexes of general formula [Ru(eta(5)-C(5)H(5))(PP) L][CF(3)SO(3)], where PP is 1,2-bis(diphenylphosphino)ethane and L is 1,3,5-triazine (Tzn) 1 or PP is 2x triphenylphosphine and L is pyridazine (Pyd) 2 has been investigated. Crystal structures of compounds 1 and 2 were determined by X-ray diffraction studies. Atomic force microscopy (AFM) images suggest different mechanisms of interaction with the plasmid pBR322 DNA; while the mode of binding of compound 1 could be intercalation between base pairs of DNA, compound 2 might be involved in a covalent bond formation with N from the purine base.
authors.affiliation: Centro de Ciências Moleculares e Materiais, Faculdade de Ciências da Universidade de Lisboa, Campo Grande, Ed. C8, 1749-016 Lisboa, Portugal. lena.garcia@fc.ul.pt
authors.forename: M
authors.initials: M
authors.lastname: Helena Garcia
authors.forename: Tânia S
authors.initials: TS
authors.lastname: Morais
authors.forename: Pedro
authors.initials: P
authors.lastname: Florindo
authors.forename: M Fátima M
authors.initials: MF
authors.lastname: Piedade
authors.forename: Virtudes
authors.initials: V
authors.lastname: Moreno
authors.forename: Carlos
authors.initials: C
authors.lastname: Ciudad
authors.forename: Veronica
authors.initials: V
authors.lastname: Noe
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000378:metabolism; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D006801:Humans; D008024:Ligands; D018625:Microscopy, Atomic Force; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000378:metabolism; D012428:Ruthenium / Q000494:pharmacology*
chemical_list: C539770:(eta(5)-cyclopentadienyl)(1,2-bis(diphenylphosphine)ethane)(1,3,5-triazine)ruthenium(II); C539771:(eta(5)-cyclopentadienyl)(pyridazine)bis(triphenyphosphine)ruthenium(II); D000970:Antineoplastic Agents; D008024:Ligands; D009942:Organometallic Compounds; D012428:Ruthenium; D004247:DNA