Dynamic changes in brain activity during prism adaptation.
Prism adaptation does not only induce short-term sensorimotor plasticity, but also longer-term reorganization in the neural representation of space. We used event-related fMRI to study dynamic changes in brain activity during both early and prolonged exposure to visual prisms. Participants performed a pointing task before, during, and after prism exposure. Measures of trial-by-trial pointing errors and corrections allowed parametric analyses of brain activity as a function of performance. We show that during the earliest phase of prism exposure, anterior intraparietal sulcus was primarily implicated in error detection, whereas parieto-occipital sulcus was implicated in error correction. Cerebellum activity showed progressive increases during prism exposure, in accordance with a key role for spatial realignment. This time course further suggests that the cerebellum might promote neural changes in superior temporal cortex, which was selectively activated during the later phase of prism exposure and could mediate the effects of prism adaptation on cognitive spatial representations.
Luauté
Jacques
J
Université de Lyon, Université Lyon 1, Inserm UMR-S 864, 69500 Bron, France. jacques.luaute@chu-lyon.fr
Schwartz
Sophie
S
Rossetti
Yves
Y
Spiridon
Mona
M
Rode
Gilles
G
Boisson
Dominique
D
Vuilleumier
Patrik
P
D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007909:Lenses; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D017711:Nonlinear Dynamics; D010100:Oxygen / Q000097:blood; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology; D055815:Young Adult
D010100:Oxygen