Effects of fenamate on inhibitory postsynaptic currents in Purkinje's cells.
The effects of nonsteroid antiinflammatory drugs of the fenamate group (mefenamic and tolfenamic acids) on spontaneous miniature inhibitory postsynaptic currents in Purkinje's cells were studied in mouse cerebellar slices by the whole cell patch-clamp method. Both drugs in concentrations of 3-30 microM significantly prolonged miniature inhibitory postsynaptic currents and reduced their amplitude.
Dvorzhak
A Yu
AY
Department of Brain Studies, Institute of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. a_dvorzhak@mail.ru
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D066298:In Vitro Techniques; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects*; D008528:Mefenamic Acid / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D055369:Miniature Postsynaptic Potentials / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D011689:Purkinje Cells / Q000187:drug effects* / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D062367:ortho-Aminobenzoates; D008528:Mefenamic Acid; C009500:tolfenamic acid; D005680:gamma-Aminobutyric Acid