[Anti-virus response and interferon, cytokine systems in patients with chronic hepatitis C].
OBJECTIVE
Determination of interferon and cytokine indices in patients with chronic virus hepatitis C.


METHODS
The significance of interferon and cytokine indices in patients with chronic viral hepatitis C (VHC) as criteria of efficacy of antiviral therapy was studied in 81 patients with chronic VHC.


RESULTS
High efficacy of interferon and ribamidil preparations against HCV is shown. Correlations between interferon and cytokine indices confirmed development of immune response by a Th1-type in responders.


CONCLUSIONS
Interferon and cytokine profiles before the treatment and in its course are proposed as criteria of antivirus treatment efficacy in chronic VHC patients.
Makashova
V V
VV
Florianu
A I
AI
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology*; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000627:therapeutic use*; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use*; D055815:Young Adult
D000998:Antiviral Agents; D016207:Cytokines; D010446:Peptide Fragments; C069261:interferon gamma (1-39); D012254:Ribavirin; D007371:Interferon-gamma