title: Two novel MICA alleles, MICA*054 and MICA*056.
abstract: We report the identification of two novel major histocompatibility complex (MHC) class I-related chain A (MICA) alleles. MICA*054 has a nucleotide substitution of A to G at position 871 (codon 268), encoding an amino acid change of serine to glycine in the alpha-3 domain. MICA*056 has a nucleotide substitution at position 758 of G to C resulting in the substitution of tryptophan for serine at codon 230, also in the alpha-3 domain.
authors.affiliation: The Anthony Nolan Research Institute and Trust, The Royal Free Hospital, London, UK. steven.cox@anthonynolan.org.uk
authors.forename: S T
authors.initials: ST
authors.lastname: Cox
authors.forename: H A F
authors.initials: HA
authors.lastname: Stephens
authors.forename: R
authors.initials: R
authors.lastname: Fernando
authors.forename: J
authors.initials: J
authors.lastname: Grant
authors.forename: J A
authors.initials: JA
authors.lastname: Madrigal
authors.forename: A-M
authors.initials: AM
authors.lastname: Little
mesh_terms: D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
chemical_list: D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A