Application of silicon nanowires and indium tin oxide surfaces in desorption electrospray ionization.
Two nanostructured surfaces are introduced as advantageous substrates for desorption electrospray ionization mass spectrometry (DESI-MS). Nano-assisted laser desorption/ionization (NALDI) plates coated with silicon nanowires (SiNWs) and indium tin oxide (ITO) layers on glass are both conductive non-polar surfaces that were originally designed as superior substrates for matrix-free laser desorption/ionization. In this study, NALDI/SiNWs and ITO were tested as potentially useful DESI substrates for selected model analytes (cyclosporine, beauverolide, surfactin and nystatin). Both nanostructured surfaces produced more intense and longer-lasting signals than other tested surfaces (polytetrafluoroethylene, glass, polymethylmethacrylate and chromatography paper).
Pól
Jaroslav
J
Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic. jaroslav.pol@helsinki.fi
Novák
Petr
P
Volný
Michael
M
Kruppa
Gary H
GH
Kostiainen
Risto
R
Lemr
Karel
K
Havlícek
Vladimír
V
D016572:Cyclosporine / Q000737:chemistry; D049329:Nanostructures; D053770:Nanowires; D015203:Reproducibility of Results; D012825:Silicon / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013499:Surface Properties; D017971:Tin Compounds / Q000737:chemistry*; D035501:Uncertainty
D017971:Tin Compounds; C109984:indium tin oxide; D016572:Cyclosporine; D012825:Silicon