title: Acute versus chronic myocardial ischemia: a differential biological profile study.
abstract: OBJECTIVE
  To determine the possible differences in lipid, thrombogenic and inflammatory marker concentrations and the presence of chronic and acute coronary artery disease (stable and unstable angina, respectively), comparing them with a group of control patients with normal coronary arteries.
  
  
  METHODS
  This prospective cohort study included 125 patients with unstable angina, 189 with stable angina and a control group of 83 patients with normal coronary arteries. Marker concentrations were measured in all 3 groups. Logistic regression analysis was performed to determine whether such factors could predict unstable or stable angina.
  
  
  RESULTS
  Lipid parameter concentrations were similar in the 2 coronary disease groups and significantly lower than in controls. Haemostatic and inflammatory marker concentrations were higher in patients with coronary disease, but were statistically significant only when comparing unstable angina patients with normal controls. Unstable angina patients had significantly higher levels of lipoprotein (a) [Lp(a)], fibrinogen, C-reactive protein (CRP) and leucocytes. Multiple logistic regression analysis showed that CRP (OR 2.635, 95% CI 1.417-4.898), smoking (OR 3.416, 95% CI 1.773-6.584), leucocytes (OR 2.034, 95% CI 1.079-3.836) and Lp(a) (OR 2.269, 95% CI 1.188-4.334) were independent risk factors of unstable versus stable angina.
  
  
  CONCLUSIONS
  Patients with unstable angina present a more atherogenic profile than patients with stable angina. Together with smoking, elevated Lp(a), CRP and leucocyte concentrations proved to be associated with the presence of unstable angina.
authors.affiliation: Servicio Cardiología, Hospital de Basurto, Departamento de Medicina, Universidad del País Vasco UPV/EHU, Bilbao, Spain.
authors.forename: José Domingo
authors.initials: JD
authors.lastname: Sagastagoitia
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Sáez
authors.forename: Marta
authors.initials: M
authors.lastname: Vacas
authors.forename: Idoia
authors.initials: I
authors.lastname: Narváez
authors.forename: Jesús Pablo Sáez
authors.initials: JP
authors.lastname: de Lafuente
authors.forename: Enrique
authors.initials: E
authors.lastname: Molinero
authors.forename: Antonio
authors.initials: A
authors.lastname: Escobar
authors.forename: Manuel
authors.initials: M
authors.lastname: Lafita
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Iriarte
mesh_terms: D000208:Acute Disease; D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000209:etiology* / Q000473:pathology; D015415:Biomarkers / Q000032:analysis; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007249:Inflammation; D007958:Leukocyte Count; D008055:Lipids / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D017566:Microvascular Angina / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology* / Q000473:pathology; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking; D013927:Thrombosis
chemical_list: D015415:Biomarkers; D008055:Lipids; D017270:Lipoprotein(a)