title: Clinical applications of demineralized bone matrix: a retrospective and case-matched study of seventy-five dogs.
abstract: OBJECTIVE
  To evaluate the outcome in dogs treated with demineralized bone matrix (DBM) as an adjunct to orthopedic procedures.
  
  
  METHODS
  Retrospective and case-match study.
  
  
  METHODS
  Dogs (n=75).
  
  
  METHODS
  Medical records (1999-2006) and radiographs of dogs that had orthopedic procedures (comminuted fractures, tibial plateau leveling osteotomy [TPLO] where correction for tibial rotation created an osteotomy gap, arthrodeses, open corrective osteotomies) where DBM was used were reviewed for signalment, quantity of DBM implanted, duration of exercise restriction, radiographic healing, and complications. Dogs that had TPLO and correction of tibial torsion (n=15), or arthrodesis (n=16) were compared with case-matched controls. Data were analyzed using Kruskal-Wallis test, ANOVA, Tukey's HSD test, and logistic regression analysis.
  
  
  RESULTS
  Mean (+/-SD) healing time for orthopedic surgeries with DBM augmentation were 15+/-6.97 (weeks) and complication rate was 19% (14 dogs). Dogs with a TPLO gap filled with DBM were allowed to return to normal exercise 2 weeks earlier than dogs with a well-apposed TPLO site. Radiographic healing, duration of exercise restriction, and timing of destabilization were similar in dogs undergoing carpal and tarsal arthrodesis whether they received DBM, autogenous graft, or both.
  
  
  CONCLUSIONS
  DBM can be used to treat uncomplicated bone defects associated with comminuted fracture repairs, open osteotomies, and arthrodeses in dogs. Under these circumstances, clinicians might expect similar clinical outcomes without the possibility of side effects associated with the harvest of autogenous cancellous bone.
  
  
  CONCLUSIONS
  DBM is safe for use in dogs.
authors.affiliation: University of Illinois Veterinary Teaching Hospital, Urbana, IL 61802, USA. mhoffer@uiuc.edu
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Hoffer
authors.forename: Dominique J
authors.initials: DJ
authors.lastname: Griffon
authors.forename: David J
authors.initials: DJ
authors.lastname: Schaeffer
authors.forename: Ann L
authors.initials: AL
authors.lastname: Johnson
authors.forename: Michael W
authors.initials: MW
authors.lastname: Thomas
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001857:Bone Matrix / Q000637:transplantation*; D016723:Bone Remodeling; D018786:Bone Substitutes; D016022:Case-Control Studies; D004285:Dogs / Q000293:injuries* / Q000601:surgery; D005260:Female; D017102:Fracture Healing / Q000502:physiology*; D018460:Fractures, Comminuted / Q000628:therapy / Q000662:veterinary*; D008297:Male; D010027:Osteotomy / Q000379:methods / Q000662:veterinary; D012189:Retrospective Studies; D013978:Tibial Fractures / Q000628:therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D018786:Bone Substitutes