title: Endoscopic features predictive of gastric cancer in superficial lesions with biopsy-proven high grade intraepithelial neoplasia.
abstract: OBJECTIVE
  To investigate the macroscopic and clinico-pathologic features of gastric cancer in patients with biopsy-suggested high grade intraepithelial neoplasia.
  
  
  METHODS
  Patients with biopsy-confirmed gastric high grade intraepithelial neoplasia were reviewed from January 2001 to March 2008. Pathologic sections were re-evaluated by two senior pathologists. Patients with an en-bloc resection of the lesion within two months after the diagnosis of high grade intraepithelial neoplasia were enrolled in the study. Clinical manifestations, endoscopic features, biopsy and surgical pathology of all patients were collected and analyzed. The data acquired were subjected to univariate and multivariate analysis.
  
  
  RESULTS
  Seventy-two superficial gastric lesions with a pathologic diagnosis of high grade intraepithelial neoplasia based on biopsy specimens were enrolled. True high grade intraepithelial neoplasia was finally proved in 16 lesions and gastric cancer in the rest 56 lesions, most of which (96.4%) were differentiated carcinomas. The result of univariate analysis indicated that the size and the presence of marked ulcer plaque or scar in a superficial lesion were independently associated with gastric cancer (P<0.05), when high grade intraepithelial neoplasia was diagnosed by biopsy pathology. The results of multivariate analysis revealed the size greater than 1.5 cm [odds ratio (OR) 18.400, P<0.001] and the presence of 5-odd mm ulcer plaque or scar (OR 10.000, P=0.044) were associated with gastric cancer. Accordingly, the sensitivity, specificity and negative predictive value of multivariate analysis for predicting "true high grade intraepithelial neoplasia" was 87.5%, 89.3% and 96.2%, respectively.
  
  
  CONCLUSIONS
  Macroscopic findings are of value in differentiation between high grade intraepithelial neoplasia and superficial gastric cancer. This may simplify patient work-up and save costs for patients and healthcare system.
authors.affiliation: Department of Gastroenterology, Shanghai Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, 197 Ruijin Er Road, Shanghai 200025, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Yun-Lin
authors.initials: YL
authors.lastname: Wu
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Zhu
authors.forename: Qing
authors.initials: Q
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Zheng-Gang
authors.initials: ZG
authors.lastname: Zhu
authors.forename: Yao-Zong
authors.initials: YZ
authors.lastname: Yuan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002278:Carcinoma in Situ / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery