[Study of the peculiarities of inheritance of latent autoimmune diabetes in adults (LADA)].
Latent autoimmune diabetes in adults (LADA) genetic determination was studied. It has been shown that LADA is genetically independent diabetes mellitus clinical form. Its heredity predisposition is described by polygene threshold model. In this model the genetic factors play the essential role and there are non-linear genetic interactions. High amount of the common genes with type 1 and 2 diabetes mellitus in LADA liability (65.3 and 66.1%) causes peculiarities of its clinical course (presence of islet cell autoantibodies, insulin-dependency and necessity in insulin therapy).
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D000328:Adult; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D009679:Nuclear Family