title: In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment.
abstract: The presence of intralesional natural regulatory T cells, characterized by the expression of Foxp3 mRNA, was analyzed in patients with localized leishmaniasis due to Leishmania guyanensis infection that was unresponsive to treatment with pentamidine isethionate. Foxp3 mRNA levels were associated with unresponsiveness to treatment among patients with a lesion duration of 1 month, but this association was not observed among patients with a lesion duration of <1 month. In conclusion, high intralesional expression of Foxp3 might be an indicator of poor response to treatment, depending on the duration of lesions.
authors.affiliation: Immunologie des Leishmanioses, Institut Pasteur de la Guyane, EA 2188, Centre Hospitalier Andrée Rosemon, Cayenne, French Guyana.
authors.forename: Eliane
authors.initials: E
authors.lastname: Bourreau
authors.forename: Catherine
authors.initials: C
authors.lastname: Ronet
authors.forename: Edith
authors.initials: E
authors.lastname: Darsissac
authors.forename: Marie-Claire
authors.initials: MC
authors.lastname: Lise
authors.forename: Dominique Sainte
authors.initials: DS
authors.lastname: Marie
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Clity
authors.forename: Fabienne
authors.initials: F
authors.lastname: Tacchini-Cottier
authors.forename: Pierre
authors.initials: P
authors.lastname: Couppie
authors.forename: Pascal
authors.initials: P
authors.lastname: Launois
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics* / Q000378:metabolism; D018334:Leishmania guyanensis / Q000187:drug effects*; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D010419:Pentamidine / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D017211:Treatment Failure
chemical_list: D000981:Antiprotozoal Agents; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D012333:RNA, Messenger; D016753:Interleukin-10; D010419:Pentamidine