Review article: Leukocyte-endothelial dysregulation in systemic small vessel vasculitis.
Aberrant interaction between the leukocyte and the endothelial cell (EC) results in the uncontrolled inflammation seen in systemic small vessel vasculitis. This review discusses our current understanding of this process and includes consideration of the role of adhesion molecules, proteases and the neutrophil respiratory burst. The effects of anti-neutrophil cytoplasm antibodies and anti-endothelial cell antibodies and their pathogenic roles are examined, and we look at experimental disease models. Specificity of disease-targetted endothelial beds and the role of circulating EC are discussed.
Pankhurst
Tanya
T
Renal Institute of Birmingham, University of Birmingham, UK.
Savage
Caroline O S
CO
Little
Mark A
MA
D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000502:physiology; D001323:Autoantibodies / Q000502:physiology; D018925:Chemokines / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D004195:Disease Models, Animal; D042783:Endothelial Cells / Q000276:immunology / Q000502:physiology*; D006801:Humans; D016023:Integrins / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D019007:P-Selectin / Q000502:physiology; D016897:Respiratory Burst; D014657:Vasculitis / Q000209:etiology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D018925:Chemokines; D016207:Cytokines; D016023:Integrins; D019007:P-Selectin; C087589:anti-endothelial cell antibody