title: Nickel-catalyzed regioselective hydroalkynylation of styrenes: improved catalyst system, reaction scope, and mechanism.
abstract: Addition of the sp-C-H bond of triisopropylsilylacetylene to the carbon-carbon double bonds of styrenes bearing functional groups proceeded efficiently at room temperature in the presence of 3 mol % of Ni(cod)(2) with a PMePh(2) ligand. Use of 2-deuteriotriisopropylsilylacetylene in the hydroalkynylation of styrenes resulted in regioselective incorporation of deuterium into the beta-positions of recovered styrenes, along with its regioselective introduction into the product's methyl group.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto 615-8510, Japan.
authors.forename: Masamichi
authors.initials: M
authors.lastname: Shirakura
authors.forename: Michinori
authors.initials: M
authors.lastname: Suginome