title: Does maternal role functioning improve with antidepressant treatment in women with postpartum depression?
abstract: OBJECTIVE
  The ability to mother her infant is reduced in a woman with postpartum depression (PPD). Although antidepressant treatment effectively improves depressive symptoms, various domains of functioning, for example, work and relationships, do not universally improve with treatment. In this pilot study, we investigated whether maternal role functioning improved with antidepressant treatment in women with PPD.
  
  
  METHODS
  The pilot study was an exploratory analysis of a larger study. A subset of women (n = 27) from a randomized clinical trial (double-blind, 8-week trial of nortriptyline compared with sertraline) completed three outcome measures of maternal role functioning: gratification in the maternal role, the Infant Care Survey (ICS), and videotapes of maternal-infant interaction. The tapes were analyzed using the Child and Caregiver Mutual Regulation Coding Scale and Noldus Behavioral Coding Software.
  
  
  RESULTS
  The two antidepressants were equally efficacious in decreasing depressive symptoms and improving overall functioning and gratification in the maternal role. Differences between times 1 and 2 in the mother-infant interactions were related to time (increasing age of the infant) and not assignment of antidepressant or remission of depression.
  
  
  CONCLUSIONS
  Effective treatment with two antidepressants improves gratification in the maternal role but not self-efficacy or maternal-infant interaction in women with PPD. Results of the study can help women and their healthcare providers to weigh the benefits of short-term antidepressant treatment in the postpartum period. Future studies should consider outcomes related to a longer duration of treatment.
authors.affiliation: School of Nursing and School of Medicine, University of Louisville, Louisville, KY 40202, USA. mclogs01@gwise.louisville.edu
authors.forename: M Cynthia
authors.initials: MC
authors.lastname: Logsdon
authors.forename: Katherine
authors.initials: K
authors.lastname: Wisner
authors.forename: Barbara H
authors.initials: BH
authors.lastname: Hanusa
mesh_terms: D000293:Adolescent; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D019052:Depression, Postpartum / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005783:Gender Identity; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D007223:Infant; D007224:Infant Care / Q000379:methods / Q000523:psychology*; D007231:Infant, Newborn; D008425:Maternal Behavior / Q000187:drug effects* / Q000523:psychology; D009034:Mother-Child Relations; D009035:Mothers / Q000523:psychology; D009661:Nortriptyline / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D020377:Self Efficacy; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000929:Antidepressive Agents, Tricyclic; D009661:Nortriptyline; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline