Ethanol for cardiac ischemia: the role of protein kinase c.
The physiological effects of ethanol are dependent upon the amount and duration of consumption. Chronic excessive consumption can lead to diseases such as liver cirrhosis, and cardiac arrhythmias, while chronic moderate consumption can have therapeutic effects on the cardiovascular system. Recently, it has also been observed that acute administration of ethanol to animals prior to an ischemic event provides significant protection to the heart. This review focuses on the different modalities of chronic vs. acute ethanol consumption and discusses recent evidence for a protective effect of acute ethanol exposure and the possible use of ethanol as a therapeutic agent.
Churchill
Eric N
EN
Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, USA.
Disatnik
Marie-Helene
MH
Budas
Grant R
GR
Mochly-Rosen
Daria
D
D000818:Animals; D002492:Central Nervous System Depressants / Q000627:therapeutic use*; D000431:Ethanol / Q000627:therapeutic use*; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*
D002492:Central Nervous System Depressants; D000431:Ethanol; D011493:Protein Kinase C