title: Pien Tze Huang, a composite Chinese traditional herbal extract, affects survival of neuroblastoma cells.
abstract: Pien Tze Huang is a popular Chinese medicine for liver diseases. In the investigations of possible effects of Pien Tze Huang on the central nervous system, we first studied the in vitro anti-cancer activity of Pien Tze Huang on neuroblastoma cells (SH-SY5Y) as compared with normal fibroblasts (NIH-3T3). Results showed that Pien Tze Huang significantly decreased (p < .05) cell survival of SH-SY5Y as compared to NIH-3T3. Furthermore, the decreases in cell survival of SH-SY5Y were significantly and linearly dose-dependent (p < .05) from 400 to 1,000 microg/ml. This supports further in vivo and animal studies for anti-cancer effect, neuroprotection, and their mechanisms.
authors.affiliation: Department of Anatomy, Zhongshan School of Medicine, Sun Yat-Sen University Guangzhou, Guangdong, China.
authors.forename: Lanhai
authors.initials: L
authors.lastname: Lü
authors.forename: Maria S M
authors.initials: MS
authors.lastname: Wai
authors.forename: David T
authors.initials: DT
authors.lastname: Yew
authors.forename: Ying T
authors.initials: YT
authors.lastname: Mak
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D041681:NIH 3T3 Cells; D009423:Nervous System Neoplasms / Q000188:drug therapy*; D009447:Neuroblastoma / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; C539975:pien tze huang