title: Prognostic study of cardiac events in Japanese high risk hemodialysis patients using I-BMIPP-SPECT: B-SAFE study design.
abstract: Cardiovascular disease is the leading cause of morbidity and mortality in patients undergoing hemodialysis. Such patients frequently develop complications such as asymptomatic coronary artery disease (CAD). Accordingly, CAD must ideally be diagnosed at an early stage to improve prognosis. Although myocardial perfusion single photon emission computed tomography (SPECT) is valuable for diagnosing CAD, the stress test is not always applicable to patients on hemodialysis. Thus, we proposed a multicenter, prospective cohort study called "B-SAFE" to investigate the applicability of resting (123)I-labeled beta-methyl-iodophenylpentadecanoic acid ((123)I-BMIPP)-SPECT will be used to diagnose cardiac disease and evaluate the prognosis of hemodialysis patients by imaging myocardial fatty acid metabolism. B-SAFE began enrolling patients from June 2006 at 48 facilities. We performed (123)I-BMIPP-SPECT on 702 hemodialysis patients with risk factors for CAD until 30 November 2007 and plan to follow up for three years. The primary endpoints will be cardiac death and sudden death. This study should end in 2010.
authors.affiliation: Cardiovascular Respiratory and Neurology Division, Department of Internal Medicine, Asahikawa Medical College, Asahikawa, Japan. haselove@asahikawa-med.ac.jp
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hasebe
authors.forename: Masao
authors.initials: M
authors.lastname: Moroi
authors.forename: Masato
authors.initials: M
authors.lastname: Nishimura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Hara
authors.forename: Hiroki
authors.initials: H
authors.lastname: Hase
authors.forename: Akiyoshi
authors.initials: A
authors.lastname: Hashimoto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
authors.forename: Kazuo
authors.initials: K
authors.lastname: Haze
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Momose
authors.forename: Yoji
authors.initials: Y
authors.lastname: Nagai
authors.forename: Tokuichiro
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiba
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Nakata
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Nishimura
authors.forename: Nagara
authors.initials: N
authors.lastname: Tamaki
authors.forename: Kenjiro
authors.initials: K
authors.lastname: Kikuchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D006435:Renal Dialysis; D012307:Risk Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid