[Effect of intravaginal administration of antibiotics of different groups on microbiocenosis of the urogenital tract in mice].
The changes of qualitative and quantitative composition of microflora of the urogenital tract have been investigated in mice at intravaginal introduction of antibiotics belonging to Fluorchinolons, Penicillinums and Tetracyclinums. It is established, that the load by antibiotics amoxicilline/clavulanic acid, doxycycline and ofloxacinum results in development of adysbiosis condition in urogenital tract, that is expressed in a significant decrease of quantity of Lactobacilli and increase of occurrence of the representatives of conditionally pathogenous flora (Staphylococcuses, Streptococcuses, representatives of family Enterobacteriaceae). An increase of the ratio between the quantity of anaerobes and aerobes is observed when introducing antibiotic preparations. Thus, in the control group the ratio makes 74:1, in the group of animals, which were administered ofloxacinum--95:1, in the group of animals, which were administered amoxicilline/clavulanic acid--132:1, and in the group of animals, which received doxycycline--115:1.
Voronkova
O S
OS
Polishko
T M
TM
Sirokvasha
O A
OA
Vinnikov
A I
AI
D000282:Administration, Intravaginal; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001420:Bacteria, Aerobic / Q000254:growth & development* / Q000302:isolation & purification; D001421:Bacteria, Anaerobic / Q000254:growth & development* / Q000302:isolation & purification; D005260:Female; D051379:Mice; D014566:Urogenital System / Q000187:drug effects* / Q000382:microbiology
D000900:Anti-Bacterial Agents