title: Live immunization against East Coast fever--current status.
abstract: The infection-and-treatment method (ITM) for immunization of cattle against East Coast fever has historically been used only on a limited scale because of logistical and policy constraints. Recent large-scale deployment among pastoralists in Tanzania has stimulated demand. Concurrently, a suite of molecular tools, developed from the Theileria parva genome, has enabled improved quality control of the immunizing stabilate and post-immunization monitoring of the efficacy and biological impact of ITM in the field. This article outlines the current status of ITM immunization in the field, with associated developments in the molecular epidemiology of T. parva.
authors.affiliation: VetAgro Tanzania Ltd, PO Box 13188, Arusha, Tanzania.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Giulio
authors.forename: Godelieve
authors.initials: G
authors.lastname: Lynen
authors.forename: Subhash
authors.initials: S
authors.lastname: Morzaria
authors.forename: Chris
authors.initials: C
authors.lastname: Oura
authors.forename: Richard
authors.initials: R
authors.lastname: Bishop
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002417:Cattle; D010118:Oxytetracycline / Q000627:therapeutic use; D016052:Protozoan Vaccines / Q000191:economics / Q000276:immunology*; D013801:Theileriasis / Q000188:drug therapy / Q000191:economics / Q000276:immunology*
chemical_list: D000900:Anti-Bacterial Agents; D016052:Protozoan Vaccines; D010118:Oxytetracycline