Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds.
In a search for potential cancer chemopreventive agents from natural resources, stevioside (1), a sweetener, and six related compounds, including two aglycones steviol (6) and isosteviol (7), were screened in an in vitro assay for inhibitory effects on Epstein-Barr virus early antigen activation. Compounds 1, 6 and 7 showed significant activity in this assay and also exhibited strong inhibitory effects in a two-stage carcinogenesis test using mouse skin induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA). The inhibitory effects of these three compounds were greater than that of glycyrrhizin. Furthermore, these three compounds significantly inhibited mouse skin carcinogenesis initiated by peroxynitrite and promoted by TPA. Their activities were comparable to that of curcumin. These results suggested that 1, as well as 6 and 7, could be valuable as chemopreventive agents for chemical carcinogenesis.
Takasaki
Midori
M
Faculty of Pharmaceutical Sciences, Chiba Institute of Science, Choshi, Chiba 288-0025, Japan.
Konoshima
Takao
T
Kozuka
Mutsuo
M
Tokuda
Harukuni
H
Takayasu
Junko
J
Nishino
Hoyoku
H
Miyakoshi
Masazumi
M
Mizutani
Kenji
K
Lee
Kuo-Hsiung
KH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D015197:Carcinogenicity Tests; D018890:Chemoprevention / Q000379:methods; D003474:Curcumin; D045786:Diterpenes, Kaurane / Q000737:chemistry* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D019695:Glycyrrhizic Acid; D004854:Herpesvirus 4, Human / Q000187:drug effects; D051379:Mice; D012878:Skin Neoplasms / Q000139:chemically induced / Q000517:prevention & control
D000970:Antineoplastic Agents; D045786:Diterpenes, Kaurane; D005960:Glucosides; C515747:isosteviol; C012043:stevioside; C012042:steviol; D019695:Glycyrrhizic Acid; D003474:Curcumin