title: Microwave-assisted combinatorial synthesis of new 3-pyrimidin-5-ylpropanamides via a solvent-dependent chemoselective reaction.
abstract: A series of new 3-pyrimidin-5-ylpropanamides was selectively synthesized via a microwave-assisted, chemoselective reaction of arylidene-Meldrum's acid, 6-hydroxypyrimidin-4(3H)-one, and structurally diverse amines including (S or R)-1-phenylethanamine, cyclohexanamine, and cyclopentanamine depended on nature of solvents. In this reaction, the utilization of HOAc as a solvent leads to 3-pyrimidin-5-ylpropanamides, whereas water as reaction media results in the spiro[5.5]undecane-1,5,9-triones from same starting materials. This method has the advantages of short synthetic route, operational simplicity, increased safety for small-scale high-speed synthesis, and minimal environment impact.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Key Laboratory of Biotechnology for Medicinal Plant, Xuzhou, Jiangsu 221116, PR China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Wu
authors.forename: Zheng-Guo
authors.initials: ZG
authors.lastname: Han
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Cao
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Shu
authors.initials: S
authors.lastname: Yan
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D008872:Microwaves; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: C552174:3-pyrimidin-5-ylpropanamide; D000577:Amides; D011743:Pyrimidines; D012997:Solvents