title: Antibiofilm activity of a diverse oroidin library generated through reductive acylation.
abstract: A diverse 20-compound library of analogues based on the marine alkaloid oroidin were synthesized via a reductive acylation strategy. The final target was then assayed for inhibition and dispersion activity against common proteobacteria known to form biofilms. This methodology represents a significant improvement over the generality of known methods to acylate substrates containing 2-aminoimidazoles and has the potential to have broad application to the synthesis of more advanced oroidin family members and their corresponding analogues.
authors.affiliation: Department of Chemistry, North Carolina State University, 2620 Yarbrough Drive, Raleigh, North Carolina 27695, USA.
authors.forename: T Eric
authors.initials: TE
authors.lastname: Ballard
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Richards
authors.forename: Arianexys
authors.initials: A
authors.lastname: Aquino
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Reed
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D000215:Acylation; D018441:Biofilms / Q000187:drug effects*; D010084:Oxidation-Reduction; D020560:Proteobacteria / Q000187:drug effects; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D054852:Small Molecule Libraries / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D011758:Pyrroles; D054852:Small Molecule Libraries; C077209:oroidin