title: Genome-wide analysis to predict protein sequence variations that change phosphorylation sites or their corresponding kinases.
abstract: We define phosphovariants as genetic variations that change phosphorylation sites or their interacting kinases. Considering the essential role of phosphorylation in protein functions, it is highly likely that phosphovariants change protein functions. Therefore, a comparison of phosphovariants between individuals or between species can give clues about phenotypic differences. We categorized phosphovariants into three subtypes and developed a system that predicts them. Our method can be used to screen important polymorphisms and help to identify the mechanisms of genetic diseases.
authors.affiliation: Center for Genome Science, 5 Nokbun-Dong, Eunpyung-Ku, Seoul, 122-701, Korea.
authors.forename: Gil-Mi
authors.initials: GM
authors.lastname: Ryu
authors.forename: Pamela
authors.initials: P
authors.lastname: Song
authors.forename: Kyu-Won
authors.initials: KW
authors.lastname: Kim
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Oh
authors.forename: Keun-Joon
authors.initials: KJ
authors.lastname: Park
authors.forename: Jong Hun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D014644:Genetic Variation; D023281:Genomics / Q000379:methods; D010750:Phosphoproteins / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D010766:Phosphorylation; D011494:Protein Kinases / Q000235:genetics / Q000378:metabolism*; D020539:Sequence Analysis, Protein; D012984:Software
chemical_list: D010750:Phosphoproteins; D011494:Protein Kinases