Directed Hydrozirconation of Homopropargylic Alcohols.
Homopropargylic alcohols undergo directed hydrozirconation with Schwartz reagent (Cp(2)ZrHCl) to generate vinyl-metal species in which the metal fragment is proximal to the alkoxide. Electrophilic trapping yields tri-substituted olefins in good yields with good control of regio- and stereochemistry. Experiments with a homopropargylic ether confirmed the role of the hydroxyl group in the directed hydrometalation.
Liu
Xiaofeng
X
Department of Biochemistry, The University of Texas Southwestern MedicalCenter at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9038.
Ready
Joseph M
JM