In-vitro myoglobin clearance by a novel sorbent system.
Rhabdomyolysis may lead to acute kidney injury following deposition of myoglobin in renal tubules. Although high-flux dialysis membranes may remove a substantial amount of myoglobin from plasma, this may still not be sufficient to prevent renal damage. We tested a new polymer sorbent, X-Sorb, in vitro to determine its potential to clear myoglobin from solutions. Normal saline or human serum in which myoglobin was dissolved was perfused by a peristaltic pump through a column packed with the sorbent. After a 4-hour perfusion, the myoglobin level in normal saline fell from 200,000 ng/ml to virtually undetectable (<780 ng/ml). Perfusion through the sorbent was then found to lower concentrations of dissolved myoglobin in 3 different 110-ml samples of human serum consistently by > 90% over 4 hours. X-Sorb appears to be an effective sorbent for myoglobin and warrants a trial in vivo to determine whether it is equally effective and safe.
Kuntsevich
Viktoriya I
VI
Department of Medicine, Division of Nephrology and Hypertension, Beth Israel Medical Center, New York, New York 10003, USA.
Feinfeld
Donald A
DA
Audia
Pat F
PF
Young
Wendell
W
Capponi
Vincent
V
Markella
Marianna
M
Winchester
James F
JF
D000818:Animals; D006801:Humans; D009211:Myoglobin / Q000097:blood* / Q000302:isolation & purification*; D010477:Perfusion; D010949:Plasma / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012965:Sodium Chloride / Q000378:metabolism
D009211:Myoglobin; D011108:Polymers; D012965:Sodium Chloride