Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized placebo-controlled trial.
OBJECTIVE
To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasemia.


METHODS
Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers.


RESULTS
A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients (7.9%) of the study group and 9 patients (25%) in the placebo group (P = 0.012). Hyperamylasemia occurred in 8 patients of the study group (21.1%) and 13 patients (36.1%) of the placebo group (P = 0.037).


CONCLUSIONS
Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.
Hao
Jian Yu
JY
Department of Digestion, Beijing Chaoyang Hospital Affiliated to Capital Medical University, China. ylxyyn@hotmail.com
Wu
Dong Fang
DF
Wang
Yue Zeng
YZ
Gao
Ying Xin
YX
Lang
Hai Po
HP
Zhou
Wei Zhen
WZ
D000328:Adult; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005260:Female; D006801:Humans; D034321:Hyperamylasemia / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use*; D010195:Pancreatitis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D010919:Placebos; D016896:Treatment Outcome
D010919:Placebos; D005996:Nitroglycerin