title: Detection of Helicobacter pylori in nasal polyps: preliminary report.
abstract: OBJECTIVE
  Investigation of Helicobacter pylori (HP) colonization in the nasal polyp specimens of patients with chronic rhinosinusitis (CRS).
  
  
  METHODS
  A prospective clinical trial.
  
  
  METHODS
  The study was performed in 23 adult patients with sinonasal polyposis and 15 controls with concha bullosa (CB) who underwent endoscopic sinus surgery.
  
  
  METHODS
  In all patients, gastroesophageal reflux (GER) symptoms were evaluated, and in 30 of them, the HP status of the stomach was also studied. Nasal polyps, mucosa of the middle concha, and gastric specimens were analyzed using a urease test and by Giemsa staining.
  
  
  METHODS
  We found HP in nasal polyp specimens in six CRS patients by the urease test and by histochemical analysis with Giemsa staining.
  
  
  RESULTS
  All of them had HP in gastric specimens and GER symptoms. HP was not detected in any patient with CB.
  
  
  CONCLUSIONS
  These results may have implications for a possible role of HP in CRS with polyposis. If a patient has HP in his gastric mucosa and is positive for GER symptoms, HP may be found in polyps as well. Whether HP is one of the causative agents of CRS or is a result of CRS is not known. Further studies are needed to find an answer to these questions.
authors.affiliation: Department of Otorhinolaryngology, University Hospital Zemun, Vukova, Belgrade. ljiljanamil@sezampro.yu
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Cvorovic
authors.forename: Dana
authors.initials: D
authors.lastname: Brajovic
authors.forename: Mile
authors.initials: M
authors.lastname: Strbac
authors.forename: Zoran
authors.initials: Z
authors.lastname: Milutinovic
authors.forename: Vojkan
authors.initials: V
authors.lastname: Cvorovic
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005756:Gastritis / Q000382:microbiology / Q000473:pathology; D005764:Gastroesophageal Reflux / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000382:microbiology* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000382:microbiology / Q000473:pathology; D009298:Nasal Polyps / Q000382:microbiology* / Q000473:pathology; D014420:Turbinates / Q000382:microbiology / Q000473:pathology; D014510:Urease / Q000032:analysis
chemical_list: D014510:Urease