[Liver infarcts with early HELLP syndrome and probable catastrophic antiphospholipid syndrome].
BACKGROUND
Among microangiopathic disorders of pregnancy, catastrophic antiphospholipid syndrome (CAPS) is a maternal and fetal life-threatening disorder. Hepatic involvement of this multi-systemic disorder can be confused with HELLP syndrome, occurring usually later in the course of pregnancy.


METHODS
We report a case of probable CAPS with hepatic disease in a pregnant woman at 13 week's gestation, with antiphospholipid syndrome and biological features of HELLP syndrome. Unspecific hepatic imaging, well-described in our case allowed undelayed therapy.


CONCLUSIONS
CAPS and HELLP syndrome, both severe microangiopathic disorders, may be associated. Nosological distinction does not modify treatment strategy, which is a maternal and foetal emergency, but their overlapping requires aggressive and early management.
d'Ythurbide
G
G
Service de médecine interne, Université Pierre- et-Marie-Curie, 75012 Paris, France.
Rousset
P
P
Carbonne
B
B
Cabane
J
J
Fardet
L
L
Tiev
K
K
Kettaneh
A
A
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000188:drug therapy; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004630:Emergencies; D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis*; D006801:Humans; D007238:Infarction / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging; D008099:Liver / Q000098:blood supply* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D010630:Phenindione / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000305:Adrenal Cortex Hormones; D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D010630:Phenindione; C017673:fluindione; D001241:Aspirin