How do you treat motor complications in Parkinson's disease: Medicine, surgery, or both?
The motor complications associated with levodopa therapy, namely, fluctuations in motor response and dyskinesias, occur in the majority of Parkinson's disease patients. These complications can impair a patient's quality of life and even cause pronounced disability. "Off" states that result in freezing of gait and falling are disabling for many patients. Dyskinesias most commonly occur at peak dose and typically alternate with the wearing-off state. Once these problems appear, they usually persist, and the physician needs to make continual adjustments in medications to minimize these problems. Medical treatments should be attempted before treatments such as deep brain stimulation are considered because of the potential adverse effects that are associated with surgery. The timing of surgery, however, is also important because younger patients and less advanced patients tend to have a better outcome. There is thus a need for experienced and knowledgeable physicians and surgeons who are able to handle these motor complications. This review discusses available medications and surgical approaches, and their outcomes.
Fahn
Stanley
S
Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA. fahn@neuro.columbia.edu
D046690:Deep Brain Stimulation / Q000009:adverse effects; D018491:Dopamine Agonists / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy / Q000209:etiology / Q000601:surgery; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D019635:Neurosurgical Procedures / Q000009:adverse effects; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D011788:Quality of Life; D012307:Risk Factors; D016896:Treatment Outcome
D018491:Dopamine Agonists; D007980:Levodopa