Estrogenic activity of pharmaceuticals in the aquatic environment.
In the last years pharmaceuticals have aroused great interest as environmental pollutants for their toxic effects towards non target organisms. This study wants to draw attention to a further adverse effect of drugs, the endocrine interference. The most representative drugs of the widespread classes in environment were investigated. The YES-test and the E-screen assay were performed to detect the capability of these substances to bind the human estrogenic receptor alpha (hER alpha) in comparison with 17beta-estradiol. Out of 14 tested pharmaceuticals, 9 were positive to YES-assay and 11 were positive to E-screen assay; in particular, Furosemide and the fibrates (Bezafibrate, Fenofibrate and Gemfibrozil) gave the maximal estrogenic response. Tamoxifen showed its dual activity as agonist and antagonist of hER alpha.
Isidori
Marina
M
IC-REACH, Dipartimento di Scienze della Vita, Seconda Università di Napoli, Via Vivaldi 43, I-81100 Caserta, Italy. marina.isidori@unina2.it
Bellotta
Maria
M
Cangiano
Margherita
M
Parrella
Alfredo
A
D004777:Environment; D047628:Estrogen Receptor alpha / Q000187:drug effects; D004967:Estrogens / Q000633:toxicity*; D006801:Humans; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D047628:Estrogen Receptor alpha; D004967:Estrogens; D014874:Water Pollutants, Chemical