title: [In vitro study of antiviral activity of Myramistin against subtypes H3N2 and H5N1 of influenza virus].
abstract: In vitro antiviral effect of myramistin on influenza virus (MDCK cell culture) was studied. The drug showed significant dose-dependent antiviral activity against the virus. When used prophylactically (1 hour before exposure to the virus) in subtoxic doses, myramistin was effective in inhibiting replication of the influenza virus [strains A/Aichi/2/68 (H3N2) and A/Chicken/Suzdalka/Nov-11/2005 (H5N1)]. In urgent prophylaxis (1 hour after exposure to the virus) the protective effect was less pronounced, especially when the contamination dose was high. When the drug was added 12 hours after exposure to the virus, it had no protective effect on the MDSK cell monolayer. The prospects of the myramistin use as a prophylactic agent in grippe are discussed.
authors.forename: A P
authors.initials: AP
authors.lastname: Agafonov
authors.forename: M O
authors.initials: MO
authors.lastname: Skarnovich
authors.forename: V A
authors.initials: VA
authors.lastname: Petrishchenko
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: A N
authors.initials: AN
authors.lastname: Sergeev
authors.forename: V V
authors.initials: VV
authors.lastname: Svistov
authors.forename: I V
authors.initials: IV
authors.lastname: Smirnov
authors.forename: N A
authors.initials: NA
authors.lastname: Kirichenko
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Krivoshein
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001548:Benzalkonium Compounds / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000502:physiology; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000502:physiology; D014773:Virology / Q000379:methods; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D001548:Benzalkonium Compounds; C058048:miramistin