Effects of prenatal and neonatal cadmium intoxication on the intensity of lipid peroxidation and activity of glutathione system in progeny of albino rats.
Oral treatment of pregnant or lactating rats with Cd(NO3)2 in a dose of 2 mg/kg increased plasma and erythrocyte levels of MDA and reduced glutathione, activities of glutathione-S-transferase, glutathione reductase, and gamma-glutamyl transferase in their 4-month-old progeny. Changes in the function of glutathione system and LPO intensity after cadmium intoxication during the neonatal were less pronounced than after prenatal exposure.
Slyuzova
O V
OV
Department of Biochemistry and Biophysics, N. G. Chernyshevsky Saratov State University, Russia. slyuzova@mail.ru
Stepanova
E V
EV
Temraleeva
A D
AD
Kireev
R A
RA
Ignatov
V V
VV
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D011247:Pregnancy; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism
D002104:Cadmium; D008315:Malondialdehyde; D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione