title: How is the archaeal MCM helicase assembled at the origin? Possible mechanisms.
abstract: In order for any organism to replicate its DNA, a helicase must unwind the duplex DNA in front of the replication fork. In archaea, the replicative helicase is the MCM (minichromosome maintenance) helicase. Although much is known about the biochemical properties of the MCM helicase, the mechanism of assembly at the origin of replication is unknown. In the present paper, several possible mechanisms for the loading process are described.
authors.affiliation: University of Maryland Biotechnology Institute, Center for Advanced Research in Biotechnology, 9600 Gudelsky Drive, Rockville, MD 20850, USA.
authors.forename: Nozomi
authors.initials: N
authors.lastname: Sakakibara
authors.forename: Lori M
authors.initials: LM
authors.lastname: Kelman
authors.forename: Zvi
authors.initials: Z
authors.lastname: Kelman
mesh_terms: D001105:Archaea / Q000201:enzymology*; D019843:Archaeal Proteins / Q000378:metabolism*; D004265:DNA Helicases / Q000737:chemistry / Q000378:metabolism*; D004261:DNA Replication; D019641:DNA, Archaeal / Q000378:metabolism
chemical_list: D019843:Archaeal Proteins; D019641:DNA, Archaeal; D004265:DNA Helicases