title: Role of tolerance in the development of eosinophilic gastrointestinal diseases.
abstract: Although the precise link is not completely understood, eosinophilic gastrointestinal diseases have been shown to be highly associated with atopy. Oral tolerance describes the specific suppression of immune responses to an antigen by prior administration of the antigen by the oral route. Like other allergic gastrointestinal diseases, eosinophilic gastrointestinal disorders may result from a loss of oral tolerance or a failure in the induction of tolerance. Further study to clarify the role of tolerance in the development of eosinophilic gastrointestinal diseases can help identify potential prevention strategies and therapeutic targets.
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Duke University Medical Center, Box 2898, Durham, NC 27710, USA.
authors.forename: Pooja
authors.initials: P
authors.lastname: Varshney
authors.forename: A Wesley
authors.initials: AW
authors.lastname: Burks
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000276:immunology / Q000627:therapeutic use; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003888:Desensitization, Immunologic / Q000639:trends; D004802:Eosinophilia / Q000150:complications / Q000276:immunology* / Q000628:therapy; D005512:Food Hypersensitivity / Q000150:complications / Q000276:immunology* / Q000628:therapy; D005767:Gastrointestinal Diseases / Q000150:complications / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology; D051379:Mice; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D000485:Allergens; D016207:Cytokines