title: Drug rash with eosinophilia and systemic symptoms after chlorambucil treatment in chronic lymphocytic leukaemia.
abstract: Drug rash with eosinophilia and systemic symptoms (DRESS) is a severe cutaneous drug reaction with a long duration of eruption and serious organ involvement. The mortality rate has been estimated at about 10%. Aromatic anticonvulsants, sulphamides, minocycline and more rarely carbamazepine are the principal responsible drugs. We report the first case of chlorambucil-induced DRESS syndrome in a 70-year-old man recently diagnosed with chronic lymphocytic leukaemia. He developed recurrent skin rash, fever, hypereosinophilia, and acute renal failure after rechallenge with chlorambucil. The condition improved slowly after stopping medication and systemic steroids. Prompt recognition of a chlorambucil drug reaction is essential in patients receiving chemotherapy.
authors.affiliation: Service des Maladies du Sang, Centre Hospitalier Universitaire d'Amiens, Hôpital Sud, Amiens, France.
authors.forename: I
authors.initials: I
authors.lastname: Vaida
authors.forename: F
authors.initials: F
authors.lastname: Roszkiewicz
authors.forename: B
authors.initials: B
authors.lastname: Gruson
authors.forename: R
authors.initials: R
authors.lastname: Makdassi
authors.forename: G
authors.initials: G
authors.lastname: Damaj
mesh_terms: D058186:Acute Kidney Injury / Q000188:drug therapy / Q000517:prevention & control; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000368:Aged; D002699:Chlorambucil / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D004802:Eosinophilia / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control; D005076:Exanthema / Q000139:chemically induced / Q000188:drug therapy; D005334:Fever / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy*; D008297:Male
chemical_list: D000305:Adrenal Cortex Hormones; D002699:Chlorambucil