title: Assessment of LV diastolic function in patients with beta-thalassemia major with special reference to E/Eann ratio.
abstract: OBJECTIVE
  The present study was undertaken to evaluate left ventricular function in patients with beta-thalassemia major with special reference to pulsed wave tissue Doppler imaging.
  
  
  METHODS
  The present study compared 30 diagnosed cases of beta-thalassemia major (mean age: 9.43+/-2.78 y) with 30 age-sex-matched healthy controls (mean age: 8.3+/-2.83 y) for left ventricular function assessment using following parameters: ejection fraction, mitral valve E/A ratio and E deceleration time (Edec), isovolumic relaxation time, and E/Eann ratio. Serum ferritin levels were also measured.
  
  
  RESULTS
  There was significant increase in E/Eann (9.46+/-1.5 vs. 6.16+/-2.4, P<0.0001) and significant prolongation of Edec (177.66+/-40.73 vs. 138.5, P<0.001) and isovolumic relaxation time (40.2+/-14.89 vs. 36.67+/-5.12, P<0.05) in cases as compared with controls. However, there was no significant difference in ejection fraction value (65.55+/-8.98 vs. 63.87+/-16.35) and E/A ratio (2.0386+/-0.73 vs. 2.119+/-0.92). Serum ferritin levels although increased significantly in cases (8370.85+/-2660.35), no correlation could be established between increased serum ferritin and progressive diastolic dysfunction (r=0.148, P=0.258).
  
  
  CONCLUSIONS
  Diastolic dysfunction precedes systolic dysfunction in patients with beta-thalassemia major as assessed by Edec and E/Eann ratio.
authors.affiliation: Department of Medicine, Ashwini Cooperative Hospital, Maharashtra, India. parale8@yahoo.com
authors.forename: Gurunath P
authors.initials: GP
authors.lastname: Parale
authors.forename: Swapnil S
authors.initials: SS
authors.lastname: Pawar
authors.forename: Vinay S
authors.initials: VS
authors.lastname: Tapare
mesh_terms: D001783:Blood Flow Velocity; D016022:Case-Control Studies; D002648:Child; D003971:Diastole / Q000502:physiology*; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology*; D017086:beta-Thalassemia / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*
chemical_list: D005293:Ferritins