title: The genetics and epidemiology of female sexual dysfunction: a review.
abstract: BACKGROUND
  Female sexual dysfunction (FSD) is an often underestimated and common problem with serious effects on women's quality of life. Despite a high overall prevalence in the female population--exceeding that of male sexual dysfunction--until recently, little research has focused on this area. In contrast to the successful advances of genetic research in a wide variety of human diseases, genetic exploration in FSD lags far behind.
  
  
  OBJECTIVE
  The aim of this review is to acquaint the reader with the current behavioral and molecular genetic research in the field of FSD. Methods. Because of the heterogeneity of the included studies, we are providing a nonsystematic review.
  
  
  RESULTS
  Recent epidemiological and candidate gene studies have suggested a strong genetic influence on female sexual functioning. While these findings provide a clear rationale for more genetic research in the field, they need to be replicated on a much larger scale to be definitive.
  
  
  CONCLUSIONS
  Successful identification of biomarkers and novel genes underlying FSD should improve the diagnosis, identification, and treatment of different subgroups. Future pharmacotherapeutic approaches to FSD will benefit from novel targets and the concept that individual variations have a genetic component may help destigmatize our views of sexual problems. Burri AV, Cherkas LM, and Spector TD.
authors.affiliation: Twin Research and Genetic Epidemiology Department, King's College London St Thomas' Hospital, London, UK. andrea.burri@kcl.ac.uk
authors.forename: Andrea V
authors.initials: AV
authors.lastname: Burri
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Cherkas
authors.forename: Tim D
authors.initials: TD
authors.lastname: Spector
mesh_terms: D005260:Female; D006304:Health Status; D006801:Humans; D015994:Incidence; D015995:Prevalence; D011584:Psychology; D012735:Sexual Dysfunction, Physiological / Q000145:classification / Q000453:epidemiology* / Q000235:genetics*; D020018:Sexual Dysfunctions, Psychological / Q000453:epidemiology / Q000235:genetics; D014427:Twins / Q000235:genetics