title: Effects of Nanpao, a kampo medicine, on peripheral blood flow and surface skin temperature in aged female rats.
abstract: The effects of long-term treatment with Nanpao, a kampo medicine, on cold constitution were evaluated in aged female rats. Five-month-old rats were administered Nanpao orally at doses of 0, 30, or 100 mg/kg/day. The peripheral blood flow and surface skin temperature in the hind paws were measured using a laser Doppler blood flow meter and infrared thermography, respectively. In animals treated with Nanpao, the peripheral blood flow increased dose-dependently compared to that in the control group. Moreover, the surface skin temperature after immersion in ice-cold water was higher in the Nanpao-treated groups than in the control group at all measurement times. These results suggest that Nanpao has the potential to improve cold constitution associated with decreased peripheral blood flow in women.
authors.affiliation: Safety Research Laboratory, Research Division, Mitsubishi Tanabe Pharma Corporation, Osaka-shi, Japan.
authors.forename: Masaru
authors.initials: M
authors.lastname: Ichihashi
authors.forename: Hiromi
authors.initials: H
authors.lastname: Takatani
authors.forename: Yoshikatsu
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Kouji
authors.initials: K
authors.lastname: Yano
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Nishida
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D000367:Age Factors; D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D020835:Medicine, Kampo; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow / Q000187:drug effects*; D012867:Skin / Q000098:blood supply*; D012881:Skin Temperature / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal