PNIPAM gel-coated gold nanorods for targeted delivery responding to a near-infrared laser.
Gold nanorods can be used as photothermal converters, permitting near-infrared (NIR) light to be transmitted deep into tissues without causing damage. We prepared hybrid nanorods with a core-shell structure, i.e., a single gold nanorod encapsulated in a poly (N-isopropylacrylamide) nanogel. Hybrid nanorods demonstrated remote, reversible, pulsatile phase transition and in vivo action after irradiation using a NIR laser.
Kawano
Takahito
T
Department of Applied Chemistry, Faculty of Engineering, and Center for Future Chemistry, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka 819-0395, Japan.
Niidome
Yasuro
Y
Mori
Takeshi
T
Katayama
Yoshiki
Y
Niidome
Takuro
T
D000178:Acrylamides / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry*; D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D005782:Gels; D006046:Gold / Q000737:chemistry*; D007259:Infrared Rays; D007834:Lasers; D051379:Mice; D043942:Nanotubes / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D003432:Cross-Linking Reagents; D004337:Drug Carriers; D005782:Gels; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D006046:Gold