Functional analysis of insertion sequence ISAba1, responsible for genomic plasticity of Acinetobacter baumannii.
ISAba1 is an insertion sequence that is widely distributed in Acinetobacter baumannii. We demonstrated here that ISAba1 and the composite transposon Tn2006 are capable of transposition, generating 9-bp target site duplications. The expression of the ISAba1 transposase-encoding gene was downregulated by translational frameshifting.
Mugnier
Pauline D
PD
Service de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
Poirel
Laurent
L
Nordmann
Patrice
P
D040981:Acinetobacter baumannii / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D004251:DNA Transposable Elements; D016368:Frameshift Mutation; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D016415:Sequence Alignment; D019895:Transposases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D019895:Transposases