title: [New liposomal forms of antifungal antibiotics, modified by amphiphilic polymers].
abstract: A method has been developed, for incorporating macrocyclic polyene antibiotics nistatin and amphotericin B into liposomes containing phosphatidylcholine and cholesterol (7:3) or phosphatidylcholine, cholesterol, and cardiolipin (7:3:1), the membranes of which were modified with an amphiphilic polymer of N-vinylpyrrolidone, carrying one terminal n-octadecyl group and having a molecular weight of 4000 Da. The amount of antibiotics within such liposomal nanocarriers may be as high as 17-22%. It was demonstrated that the modified liposomes have sizes in the range 150-200 nm and exhibit increased long-term storage stability and increased resistance to disrupting agents (Triton X-100 or ethanol) and ultrasound. The antifungal activity of the liposomal preparations obtained exceeded that of the antibiotics not subjected to immobilization.
authors.forename: I A
authors.initials: IA
authors.lastname: Iamskov
authors.forename: A N
authors.initials: AN
authors.lastname: Kuskov
authors.forename: K K
authors.initials: KK
authors.lastname: Babievskiĭ
authors.forename: B B
authors.initials: BB
authors.lastname: Berezin
authors.forename: M A
authors.initials: MA
authors.lastname: Kraiukhina
authors.forename: N A
authors.initials: NA
authors.lastname: Samoĭlova
authors.forename: V E
authors.initials: VE
authors.lastname: Tikhonov
authors.forename: M I
authors.initials: MI
authors.lastname: Shtil'man
mesh_terms: D000666:Amphotericin B / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes; D009761:Nystatin / Q000737:chemistry*; D017830:Octoxynol / Q000737:chemistry; D011760:Pyrrolidinones / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D008055:Lipids; D008081:Liposomes; D011760:Pyrrolidinones; D009761:Nystatin; C042670:N-vinyl-2-pyrrolidinone; D000666:Amphotericin B; D017830:Octoxynol