[Advances in sterol 14alpha-demethylase (CYP51)].
Sterol 14alpha-demethylase (CYP51), the most widely distributed member of the P450 superfamily, is the key enzyme in sterol biosynthesis pathway. CYP51 is not only an important model for fundamental P450 structure/function studies, but also an important target protein of cholesterol-lowering agents, antifungal drugs and herbicides. This article reviewed the research advances in CYP51 at various aspects, including sequence characteristics, physiological roles, catalytic properties in vitro, protein structure, structure-function relationships and inhibition of CYP51. The problems remained in current research and designations of CYP51 inhibitors are also discussed.
Yang
Jiaoyan
J
College of Life Sciences, Central China Normal University, Wuhan 430079, China.
Liao
Mingjun
M
Yang
Shao
S
D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000502:physiology; D016297:Mutagenesis, Site-Directed; D020539:Sequence Analysis, Protein; D058886:Sterol 14-Demethylase
D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System; D058886:Sterol 14-Demethylase