Localization of transforming growth factor beta3 in squamous metaplasia of the porcine oviduct: a case report.
Squamous metaplasia of the oviduct epithelium is a rare disorder of reproductive organs. We noted squamous metaplasia of the oviduct epithelium in a sow routinely slaughtered at day 2 of the oestrous cycle. Expression of transforming growth factor beta3 (TGF beta3) in the metaplastic epithelia was evaluated by immunohistochemistry, because TGF beta3 appears to play a key role as regulator of a variety of tissue remodelling events. Our results show that TGF beta3 immunostaining was specifically localized to foci of squamous metaplasia of the epithelial linings. Non-metaplastic epithelial cells of the oviduct were not immunostained with anti-TGF beta3 antibody. At the subcellular level, TGF beta3-labelled cells occasionally showed signs of apoptotic cell death. It is concluded that signals produced by TGF beta3 in metaplastic lesions of the oviduct are potentially involved in pathophysiological processes.
Steffl
M
M
Department of Anatomy and Physiology of Domestic Animals, University of Hohenheim, Stuttgart, Germany. stefflma@uni-hohenheim.de
Schweiger
M
M
Amselgruber
W M
WM
D000818:Animals; D005185:Fallopian Tube Neoplasms / Q000378:metabolism / Q000662:veterinary*; D005187:Fallopian Tubes / Q000378:metabolism / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D008679:Metaplasia / Q000378:metabolism; D018307:Neoplasms, Squamous Cell / Q000378:metabolism / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism*; D053782:Transforming Growth Factor beta3 / Q000378:metabolism*
D053782:Transforming Growth Factor beta3