title: Albidopyrone, a new alpha-pyrone-containing metabolite from marine-derived Streptomyces sp. NTK 227.
abstract: Albidopyrone, a new alpha-pyrone-containing secondary metabolite, was produced by Streptomyces sp. NTK 227, a strain isolated from Atlantic Ocean sediment and found to be a member of the Streptomyces albidoflavus 16S rRNA gene clade. The structure of the compound was determined by MS and NMR spectroscopy, and found to have a moderate inhibitory activity against protein-tyrosin phosphatase B.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hohmann
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schneider
authors.forename: Christina
authors.initials: C
authors.lastname: Bruntner
authors.forename: Roselyn
authors.initials: R
authors.lastname: Brown
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Jones
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Marco
authors.initials: M
authors.lastname: Krämer
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
authors.forename: Graeme
authors.initials: G
authors.lastname: Nicholson
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
mesh_terms: D000081:Acetamides / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011753:Pyrones / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D014871:Water Microbiology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D011753:Pyrones; C544382:albidopyrone