title: Prenatal hyperhomocysteinemia as a model of oxidative stress of the brain.
abstract: We found that methionine added to the ration of pregnant rats (1 g/kg body weight) induced sustained hyperhomocysteinemia and led to the formation of sustained oxidative stress in the brain of their progeny. Newborn animals were characterized by lower body weight, SOD deficiency in the brain, increased neuronal death, and desensitization of NMDA receptors. These factors are associated with impaired cognitive capacity in the Morris test.
authors.affiliation: M. V. Lomonosov Moscow State University, Moscow, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Makhro
authors.forename: A P
authors.initials: AP
authors.lastname: Mashkina
authors.forename: O A
authors.initials: OA
authors.lastname: Solenaya
authors.forename: O A
authors.initials: OA
authors.lastname: Trunova
authors.forename: L S
authors.initials: LS
authors.lastname: Kozina
authors.forename: A V
authors.initials: AV
authors.lastname: Arutyunian
authors.forename: E R
authors.initials: ER
authors.lastname: Bulygina
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D003071:Cognition / Q000502:physiology; D005260:Female; D005333:Fetus / Q000378:metabolism / Q000503:physiopathology; D006710:Homocysteine / Q000737:chemistry / Q000378:metabolism; D020138:Hyperhomocysteinemia / Q000378:metabolism*; D018782:Maze Learning / Q000502:physiology; D016202:N-Methylaspartate / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D006710:Homocysteine; D016202:N-Methylaspartate; D013482:Superoxide Dismutase