[Modifications of hypothalamic neurohormone expression in animal model of post-traumatic stress disorder].
Neuroendocrine mechanisms of development of anxiety-like state in rats in experimental model of human post-traumatic stress disorder (PTSD), referred to as stress-restress paradigm, have been studied. Immunocytochemistry has revealed significant increase of CRH expression in both parvo- and magnocellular subdivisions of paraventricular nuclei up to 10th post-stress day. Significant reduction of vasopressin expression in rats' hypothalamic paravntricular nuclei has been detected on the 1st post-stress day. Vasopressin immunoreactivity in hypothalamus of stressed animals was indistinguishable from that in control group on the 10th post-stress day only in parvocellular subdivision of the paraventricular nucleus, while it was increased in magnocellular subdivision of the nucleus in experimental group compared to controls. The results imply a plausible role of hypothalamic vasopressin along with CRH on the development of PTSD.
Mironova
V I
VI
Rybnikova
E A
EA
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000096:biosynthesis*; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D008297:Male; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013313:Stress Disorders, Post-Traumatic / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors; D014667:Vasopressins / Q000096:biosynthesis*
D014667:Vasopressins; D003346:Corticotropin-Releasing Hormone