title: Traditional Chinese medicine on four patients with Huntington's disease.
abstract: Four Huntington's disease (HD) patients were treated with traditional Chinese medicines Yi-Gan San (YGS) and Chaihu-Jia-Longgu-Muli Tan (CLMT) in a cross-over manner. Two patients took YGS for 8 weeks first, and after 4 weeks of washing out, they took CLMT for 8 weeks. Two other patients took these medicines in reverse order. All patients showed a decrease in the Unified Huntington's Disease Rating Scale-motor assessment (from 106.3 +/- 4.7 to 89.6 +/- 5.8 as mean +/- SD, P = 0.0004) by YGS treatment with no extrapiramidal symptoms or changes of cognition or ADL. Our study suggests a possibility of a new treatment for involuntary movements.
authors.affiliation: National Yonezawa Hospital, Yonezawa City, Yamagata, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Satoh
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Koh
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Tago
authors.forename: Takashi
authors.initials: T
authors.lastname: Seki
authors.forename: Nobuo
authors.initials: N
authors.lastname: Yaegashi
authors.forename: Muneshige
authors.initials: M
authors.lastname: Tobita
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Arai
mesh_terms: D000368:Aged; D018592:Cross-Over Studies; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D008516:Medicine, Chinese Traditional / Q000379:methods*; D008875:Middle Aged; D010865:Pilot Projects
chemical_list: D004365:Drugs, Chinese Herbal; C524644:Yi-Gan San