Prevalence of a 32 bp deletion in the gene for human immunodeficiency virus 1 co-receptor CCR5 in Slovak population.
The chemokine (C-C motif) receptor 5 (CCR5) represents a major co-receptor for macrophagetropic Human immunodeficiency virus 1 (HIV-1) strains. A 32 bp deletion mutant allele in the CCR5 gene (CCR5-Δ32) provides to homozygotes a strong resistance to HIV-1 infection. In this study, the prevalence of CCR5-Δ32 in 200 HIV-1-negative and 162 HIV-1-positive individuals was determined. The presence of CCR5-Δ32 in blood samples was detected by PCR. CCR5-Δ32 was found to be homozygous in 1% and heterozygous in 17% of the HIV-1-negative individuals. In HIV-1-positive patients, no homozygous CCR5-Δ32 was found, while heterozygous CCR5-Δ32 occurred in 15.4% patients. Thus, no significant difference between HIV-1- negative and HIV-1-positive individuals was found, what is in accord with the findings obtained in other EU countries. The results of this study do not indicate that a relatively low incidence of HIV-1 infection in Slovakia could be caused by the CCR5-Δ32 mutation.
Takácová
M
M
National Reference Center for HIV/AIDS Prevention, Slovak Medical University, Limbová 14, 833 01 Bratislava, Slovak Republic.
Nogová
P
P
Hábeková
M
M
Staneková
D
D
D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D008297:Male; D015995:Prevalence; D019713:Receptors, CCR5 / Q000235:genetics*; D011991:Receptors, Virus / Q000235:genetics*; D017384:Sequence Deletion; D018154:Slovakia / Q000453:epidemiology
D019713:Receptors, CCR5; D011991:Receptors, Virus