Prospects for improved bluetongue vaccines.
Bluetongue has been recognized as a viral disease of livestock for more than 100 years. Repeated incursions of Bluetongue into Europe since 1998 have been particularly devastating for highly sensitive European fine-wool sheep breeds, and have resulted in a resurgence of interest in vaccine manufacture. Fortunately, the virus and its serology are well understood and vaccination prevents the disease. However, current vaccines are not without their problems, and many new approaches are being tested to improve the safety and breadth of protection afforded. This review describes the leading technologies for improved bluetongue vaccines and looks ahead to how advances in other viral vaccines might be applied to this disease.
Roy
Polly
P
Department of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E7HT, UK. Polly.Roy@lshtm.ac.uk
Boyce
Mark
M
Noad
Robert
R
D000818:Animals; D001819:Bluetongue / Q000517:prevention & control*; D001820:Bluetongue virus / Q000235:genetics / Q000276:immunology*; D005060:Europe / Q000453:epidemiology; D011786:Quality Control; D012756:Sheep; D014765:Viral Vaccines / Q000592:standards
D014765:Viral Vaccines