title: Rectal misoprostol vs 15-methyl prostaglandin F2alpha for retained placenta after second-trimester delivery.
abstract: OBJECTIVE
  The purpose of this study was to compare rectal misoprostol (RM) with 15-methyl prostaglandin F2alpha (PGF(2alpha)) for the management of retained placenta after second-trimester deliveries.
  
  
  METHODS
  A retrospective study of all second-trimester deliveries between the years 2000 and 2005 was performed. Women were divided into 2 groups, depending on whether they received RM or PGF(2alpha) after the delivery.
  
  
  RESULTS
  Three hundred three second-trimester deliveries were analyzed. The time from the administration of medications to the placental delivery was significantly shorter in women who received PGF(2alpha), compared with the RM group (49.5 vs 89 minutes; P < .01). Women who received PGF(2alpha) had lower rates of retained placenta (4.9% vs 12.4%; P = .02).
  
  
  CONCLUSIONS
  The use of PGF(2alpha) after second-trimester deliveries results in shorter third stage of labor and lower rates of retained placenta compared with RM.
authors.affiliation: Department of Obstetrics and Gynecology, University of Miami, Miller School of Medicine, Miami, FL 33136, USA.
authors.forename: Subha
authors.initials: S
authors.lastname: Sundaram
authors.forename: John P
authors.initials: JP
authors.lastname: Diaz
authors.forename: Víctor Hugo
authors.initials: VH
authors.lastname: González-Quintero
authors.forename: Usha
authors.initials: U
authors.lastname: Verma
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage*; D000032:Abortion, Therapeutic / Q000379:methods*; D000285:Administration, Rectal; D000328:Adult; D002260:Carboprost / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage*; D018457:Placenta, Retained / Q000188:drug therapy*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; D002260:Carboprost