Estimation of the effects of smoking and DNA repair capacity on coefficients of a carcinogenesis model for lung cancer.
Numerous prospective and retrospective studies have clearly demonstrated a dose-related increased lung cancer risk associated with cigarette smoking, with evidence also for a genetic component to risk. In this study, using the two-stage clonal expansion stochastic model framework, for the first time we investigated the roles of both genetic susceptibility and smoking history in the initiation, clonal expansion, and malignant transformation processes in lung carcinogenesis, integrating information collected by a case-control study and a large-scale prospective cohort study. Our results show that individuals with suboptimal DNA repair capacity have enhanced transition rates of key events in carcinogenesis.
Deng
Li
L
Department of Vision Science, New England College of Optometry, Boston, MA, USA. DengL@neco.edu
Kimmel
Marek
M
Foy
Millennia
M
Spitz
Margaret
M
Wei
Qingyi
Q
Gorlova
Olga
O
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D015233:Models, Statistical; D011446:Prospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*