Relating structure to function: Heschl's gyrus and acoustic processing.
The way in which normal variations in human neuroanatomy relate to brain function remains largely uninvestigated. This study addresses the question by relating anatomical measurements of Heschl's gyrus (HG), the structure containing human primary auditory cortex, to how this region processes temporal and spectral acoustic information. In this study, subjects' right and left HG were identified and manually indicated on anatomical magnetic resonance imaging scans. Volumes of gray matter, white matter, and total gyrus were recorded, and asymmetry indices were calculated. Additionally, cortical auditory activity in response to noise stimuli varying orthogonally in temporal and spectral dimensions was assessed and related to the volumetric measurements. A high degree of anatomical variability was seen, consistent with other reports in the literature. The auditory cortical responses showed the expected leftward lateralization to varying rates of stimulus change and rightward lateralization of increasing spectral information. An explicit link between auditory structure and function is then established, in which anatomical variability of auditory cortex is shown to relate to individual differences in the way that cortex processes acoustic information. Specifically, larger volumes of left HG were associated with larger extents of rate-related cortex on the left, and larger volumes of right HG related to larger extents of spectral-related cortex on the right. This finding is discussed in relation to known microanatomical asymmetries of HG, including increased myelination of its fibers, and implications for language learning are considered.
Warrier
Catherine
C
Department of Communication Sciences and Disorders, Northwestern University, Evanston, Illinois 60208, USA. cwarrier@northwestern.edu
Wong
Patrick
P
Penhune
Virginia
V
Zatorre
Robert
R
Parrish
Todd
T
Abrams
Daniel
D
Kraus
Nina
N
D000161:Acoustic Stimulation / Q000379:methods; D000162:Acoustics; D000328:Adult; D000704:Analysis of Variance; D001303:Auditory Cortex / Q000033:anatomy & histology* / Q000098:blood supply / Q000502:physiology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D010100:Oxygen / Q000097:blood; D010829:Physiological Phenomena / Q000502:physiology*; D013057:Spectrum Analysis; D018709:Statistics, Nonparametric
D010100:Oxygen