Antibiotics for nasopharyngitis are associated with a lower risk of office-based physician visit for acute otitis media within 14 days for 3- to 6-year-old children.
OBJECTIVE
This study was designed to analyse factors potentially influencing children's return visits to physicians for symptoms of acute otitis media (AOM) within 14 days after being diagnosed with nasopharyngitis (NP), and the impact of recent antibiotic use.


METHODS
A controlled population-based pharmaco-epidemiological trial in 3- to 6-year-old children conducted from January to May 2000.


METHODS
Three different geographical regions in France.


METHODS
Among 2507 eligible children, 2456 could be analysed and 505 children had 634 office-based physician visits (OBPV) for NP symptoms.


METHODS
The statistical associations between antibiotics prescribed for NP and an OBPV for AOM within 14 days in a population-based study were analysed along with risk factors of AOM.


METHODS
Clinical events and antibiotic use.


RESULTS
During the 2 weeks following physician-diagnosed NP, antibiotic use, especially a beta-lactam, significantly decreased the risk of OBPV for AOM in children (odds ratio=0.2; 95% confidence interval=0.09-0.7; P=0.002).


CONCLUSIONS
Antibiotics prescribed to children for NP seem to protect during the following 2 weeks against the risk of OBPV for AOM. It remains to be determined whether a subgroup at high risk of developing AOM after a viral infection exists and what might be the best strategy to adopt for NP in a national programme of optimal antibiotic use.
Salomon
Jérôme
J
INSERM, U657, Paris, France. jsalomon@pasteur.fr
Sommet
Agnès
A
Bernède
Claire
C
Tonéatti
Christine
C
Carbon
Claude
C
Guillemot
Didier
D
D000208:Acute Disease; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D018942:Macrolides / Q000627:therapeutic use; D008297:Male; D009304:Nasopharyngitis / Q000150:complications / Q000188:drug therapy*; D009819:Office Visits / Q000706:statistics & numerical data*; D010033:Otitis Media / Q000209:etiology / Q000517:prevention & control*; D010820:Physicians; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D013449:Sulfonamides / Q000627:therapeutic use; D013997:Time Factors; D047090:beta-Lactams / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D018942:Macrolides; D013449:Sulfonamides; D047090:beta-Lactams