title: [Peculiarities of the organism immune response in patients suffering ischemic cardiomyopathy].
abstract: Ischemic cardiomyopathy (ICMP) constitutes the organspecific systemic form of autoimmune pathology. Now existing hypotheses of the ICMP pathogenesis trust the multistaged course of the disease with concurrent changes in the cellular and humoral chains of immunity. Among the immune disorders there are interrelated chains, influencing the disease course severity. Dysfunction of T- and B-lymphocytes, natural cell-killers (EKK-CD16+), R-IL2 (CD25+), apoptosis (CD95+), pro- and antiinflammatory cytokines causes changes in myocardium contractility, occurrence of congestion events, chronic cardiac insufficiency.
authors.forename: A M
authors.initials: AM
authors.lastname: Vorob'eva
authors.forename: E Ia
authors.initials: EIa
authors.lastname: Bespalova
authors.forename: Z T
authors.initials: ZT
authors.lastname: Balannik
authors.forename: L N
authors.initials: LN
authors.lastname: Klimova
authors.forename: V N
authors.initials: VN
authors.lastname: Lisnichaia
authors.forename: E V
authors.initials: EV
authors.lastname: Rybakova
mesh_terms: D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D009202:Cardiomyopathies / Q000209:etiology / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines