title: [Regional metastases of head and neck cutaneous squamous cell carcinoma].
abstract: Two patients, a woman aged 54 years and a man aged 76 years, developed regional metastases of head and neck cutaneous squamous cell carcinoma (HNCSCC). In general, cutaneous SCC has a low metastatic potential. However these patients illustrate that this tumour may behave aggressively, metastasising to the regional lymph nodes in the neck or parotid gland. Certain clinical and histological features of the primary tumour are associated with a higher risk for nodal metastases. In patients at risk, a more rigorous investigation for nodal metastasis is warranted at diagnosis of SCC as well as during follow-up. The extent of treatment of lymph nodes in the neck region should be directed by the location of the primary tumour, which is an indicator of the most probable lymph drainage pattern. In the case of metastatic parotid involvement, elective treatment of the neck should be considered, even when there are no clinical signs of metastasis. Treatment consists of surgery and/or ipsilateral radiotherapy.
authors.affiliation: Afd. Keel-, Neus- en Oorheelkunde, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen.
authors.forename: A R
authors.initials: AR
authors.lastname: de Heer
authors.forename: H
authors.initials: H
authors.lastname: Bouman
authors.forename: M J P
authors.initials: MJ
authors.lastname: Gerritsen
authors.forename: K J A O
authors.initials: KJ
authors.lastname: Ingels
authors.forename: J H A M
authors.initials: JH
authors.lastname: Kaanders
authors.forename: R P
authors.initials: RP
authors.lastname: Takes
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009333:Neck / Q000473:pathology / Q000601:surgery; D009361:Neoplasm Invasiveness; D010307:Parotid Neoplasms / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery