Gastrointestinal stromal tumor of the gastric serosa protruding to the greater omentum. Report of a giant tumor with a rare histological pattern.
We report an unusual case of a 76 year old woman admitted to our hospital for investigation of anemia and palpable epigastric mass. Intraoperatively a huge (19 cm), well defined tumor was found adhering to the stomach wall, protruding into the greater omentum and compressing the transverse colon. A tumorectomy was performed and the greater omentum was removed due to its close relation. Pathology revealed a high risk Gastrointestinal Stromal tumor of the gastric serosa. Histologically the tumor was of mixed type (spindle and epithelioid cells) with hem-angio-peri-cytomatoid pattern peripherally, variably myxoid stroma, central necrosis and cytologic pleomorphism. On immunohistochemical examination there was a consistent positivity for c-kit (CD-117) and CD-34, but without myogenic or neural differentiation. We consider this case unusual because of its huge size, its gastric serosal location and its extremely rare histological pattern.
Pavlakis
Emmanouel
E
2nd Department of Surgery, Asclepeion General Hospital, Athens, Greece.
Avgerinos
Efthimios
E
Stathoulopoulos
Athanasios
A
Godevenos
Dimitrios
D
Diamantopoulou
Kalliopi
K
Thomas-Tsagli
Euphemia
E
Condilis
Nicolas
N
Smailis
Dimitrios
D
Christianakis
Efstratios
E
Tsatsoulis
Panagiotis
P
Skandalakis
Panagiotis
P
Filippou
Dimitrios
D
D000368:Aged; D018952:Antigens, CD34 / Q000276:immunology; D014408:Biomarkers, Tumor / Q000276:immunology; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D009852:Omentum / Q000473:pathology / Q000601:surgery; D019009:Proto-Oncogene Proteins c-kit / Q000276:immunology; D012704:Serous Membrane / Q000473:pathology*; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome
D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit