title: Magnetic resonance elastography with a phased-array acoustic driver system.
abstract: Dynamic MR elastography (MRE) quantitatively maps the stiffness of tissues by imaging propagating shear waves in the tissue. These waves can be produced from intrinsic motion sources (e.g., due to cardiac motion), from external motion sources that produce motion directly at depth in tissue (e.g., amplitude-modulated focused ultrasound), and from external actuators that produce motion at the tissue surface that propagates into the tissue. With external actuator setups, typically only a single transducer is used to create the shear waves, which in some applications might have limitations due to shadowing and attenuation of the waves. To address these limitations, a phased-array acoustic driver system capable of applying independently controlled waveforms to each channel was developed and tested. It was found that the system produced much more uniform illumination of the object, improving the quality of the elastogram. It was also found that the accuracy of the stiffness value of any arbitrary region of interest could be improved by obtaining maximal shear wave illumination with the phased array capability of the system.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Yogesh K
authors.initials: YK
authors.lastname: Mariappan
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Rossman
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Glaser
authors.forename: Armando
authors.initials: A
authors.lastname: Manduca
authors.forename: Richard L
authors.initials: RL
authors.lastname: Ehman
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D017076:Computer-Aided Design; D054459:Elasticity Imaging Techniques / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers