Peptide-based Biopolymers in Biomedicine and Biotechnology.
Peptides are emerging as a new class of biomaterials due to their unique chemical, physical, and biological properties. The development of peptide-based biomaterials is driven by the convergence of protein engineering and macromolecular self-assembly. This review covers the basic principles, applications, and prospects of peptide-based biomaterials. We focus on both chemically synthesized and genetically encoded peptides, including poly-amino acids, elastin-like polypeptides, silk-like polymers and other biopolymers based on repetitive peptide motifs. Applications of these engineered biomolecules in protein purification, controlled drug delivery, tissue engineering, and biosurface engineering are discussed.
Chow
Dominic
D
Department of Biomedical Engineering, Duke University, Box 90281, Durham, North Carolina 27708-0281.
Nunalee
Michelle L
ML
Lim
Dong Woo
DW
Simnick
Andrew J
AJ
Chilkoti
Ashutosh
A