The influence of calcium signaling on the regulation of alternative splicing.
In this review the influence of calcium signaling on the regulation of alternative splicing is discussed with respect to its influence on cell- and developmental-specific expression of different isoforms of the plasma membrane calcium pump (PMCA). In a second part the possibility is discussed that due to the interaction of the calcium-binding protein ALG-2 with a spliceosomal regulator of alternative splicing, RBM22, Ca2+-signaling may thus influence its regulatory property.
Krebs
Joachim
J
NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. jkrebs@nmr.mpibpc.mpg.de
D017398:Alternative Splicing; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D008958:Models, Molecular; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D017433:Protein Structure, Secondary; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D002135:Calcium-Binding Proteins; D020033:Protein Isoforms; D016601:RNA-Binding Proteins; D053499:Plasma Membrane Calcium-Transporting ATPases; D002118:Calcium