Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents.
The activation state of CD4(+) T cells plays a crucial role in the establishment of a productive human immunodeficiency virus infection. Here, we show that T cells stimulated for 1 day demonstrated delayed kinetics of viral reverse transcription and integration compared to cells stimulated for 2 days prior to infection. As a result, the efficiency of reverse transcription and integration inhibitors differs in these differentially stimulated cells. These studies increase our understanding of how T cells support viral replication and provide insight regarding the efficiency of antiretroviral therapy in lymphoid compartments.
Vatakis
Dimitrios N
DN
David Geffen School of Medicine at UCLA, Department of Medicine, Division of Hematology/Oncology, Los Angeles, California 90095, USA.
Nixon
Christopher C
CC
Bristol
Gregory
G
Zack
Jerome A
JA
D019380:Anti-HIV Agents / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D002478:Cells, Cultured; D006678:HIV / Q000187:drug effects / Q000276:immunology / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D048348:Reverse Transcription
D019380:Anti-HIV Agents