Neurotropic effect of exogenous L-carnosine in cultured slices of the olfactory cortex from rat brain.
Incubation of cultured slices of the olfactory cortex from rat brain with L-carnosine in concentrations of 50, 250, and 500 M induced activation of glutamatergic and GABAB-ergic mechanisms and facilitated long-term posttetanic potentiation. The effect of L-carnosine is mediated by its effect on AMPA- and NMDA-related glutamatergic receptors and on inhibitory GABAB receptors.
Khama-Murad
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I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
Pavlinova
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Mokrushin
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AA
D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D017774:Long-Term Potentiation / Q000187:drug effects*; D016202:N-Methylaspartate / Q000378:metabolism; D009414:Nerve Growth Factors / Q000494:pharmacology*; D009833:Olfactory Pathways / Q000187:drug effects*; D051381:Rats; D018080:Receptors, GABA-B / Q000378:metabolism; D046509:Tissue Culture Techniques; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism
D009414:Nerve Growth Factors; D018080:Receptors, GABA-B; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D002336:Carnosine