title: Current status of pharmacological thrombolytic therapy and mechanical thrombectomy for the treatment of acute deep venous thrombosis.
abstract: Deep venous thrombosis (DVT) is a highly prevalent clinical problem associated with significant mortality and morbidity. In the United States alone, it is estimated that DVT affects approximately 50 per 100,000 people per year. This results in >600,000 inpatient and outpatient treatments per year and accounts for approximately 100,000 deaths from thromboembolic complications. Post-thrombotic syndrome (PTS) is associated with serious long-term physical, social and economic sequelae for patients. In this article, we attempt to perform a contemporary review of the literature pertaining to the use of thrombolytic therapy and endovascular thrombectomy in the treatment of acute DVT.
authors.affiliation: Cardiology Division, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Kiernan
authors.forename: Beatriz
authors.initials: B
authors.lastname: Cepeda
authors.forename: Gareth D
authors.initials: GD
authors.lastname: Kiernan
authors.forename: Bryan P
authors.initials: BP
authors.lastname: Yan
mesh_terms: D000208:Acute Disease; D006801:Humans; D017131:Thrombectomy / Q000379:methods* / Q000639:trends; D015912:Thrombolytic Therapy / Q000379:methods* / Q000639:trends; D020246:Venous Thrombosis / Q000150:complications / Q000628:therapy*