Original nootropic drug noopept prevents memory deficit in rats with muscarinic and nicotinic receptor blockade.
Antiamnesic activity of Noopept was studied on the original three-way model of conditioned passive avoidance response, which allows studying spatial component of memory. Cholinoceptor antagonists of both types (scopolamine and mecamylamine) decreased entry latency and reduced the probability for selection of the safe compartment. Noopept abolished the antiamnesic effect of cholinoceptor antagonists and improved spatial preference.
Radionova
K S
KS
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Belnik
A P
AP
Ostrovskaya
R U
RU
D000818:Animals; D018679:Cholinergic Agonists / Q000378:metabolism / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000378:metabolism / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology*; D008297:Male; D008464:Mecamylamine / Q000378:metabolism / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000517:prevention & control*; D018733:Nicotinic Antagonists / Q000378:metabolism / Q000494:pharmacology; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D012601:Scopolamine / Q000378:metabolism / Q000494:pharmacology
D018679:Cholinergic Agonists; D018680:Cholinergic Antagonists; D004151:Dipeptides; D018733:Nicotinic Antagonists; D018697:Nootropic Agents; C103871:ethyl phenylacetyl-Pro-Gly; D008464:Mecamylamine; D012601:Scopolamine