title: Cardiac dysautonomia and arterial distensibility in essential hypertensives.
abstract: BACKGROUND
  The central nervous system plays an important role in the regulation of blood pressure: the sympathetic nervous system may be a primary contributor to the development of some forms of essential hypertension. Hypertension is also associated with reduced distensibility of large arteries. The aim of our study is the evaluation of a correlation between cardiac dysautonomia (evaluated by means of heart rate variability [HRV]) and altered artery distensibility (evaluated by means of measurement of the time interval from the onset of the QRS wave and the detection of the last Korotkoff sound [QKD interval]).
  
  
  METHODS
  HRV and QKD interval were evaluated in 23 patients (60.9+/-8.7 years) with untreated hypertension and in 20 control subjects (53.2+/-16.8 years). QKD interval and QKD(100-60) (that is QKD for a 100 mm Hg systolic blood pressure and 60 bpm heart rate) were measured during a 24-hours blood pressure monitoring. HRV was evaluated by means of a spectral method. Three main spectral components were distinguished: very low frequency (VLF), low frequency (LF) and high frequency (HF) component.
  
  
  RESULTS
  Patients with reduced QKD(100-60) interval show reduced total power and spectral components values, with higher LF/HF ratio in basal conditions in comparison with control group. In patients with hypertension, QKD(100-60) values correlated significantly with LF/HF ratio (Spearman r=-0.551; p=0.006), HF spectral component (Spearman r=0.630; p=0.001) and total power (Spearman r=0.426; p=0.004).
  
  
  CONCLUSIONS
  Our results suggest that sympathetic overactivity may be the contributor of reduced arterial distensibility observed in patients with essential hypertension.
authors.affiliation: Department of Clinical Medicine and Immunological Sciences, Section of Internal Medicine, University of Siena, Siena, Italy. M.Acampa@ao-siena.toscana.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Acampa
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchi
authors.forename: Francesca
authors.initials: F
authors.lastname: Guideri
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lamberti
authors.forename: Fulvio
authors.initials: F
authors.lastname: Bruni
authors.forename: Marcello
authors.initials: M
authors.lastname: Pastorelli
authors.forename: Giovanni
authors.initials: G
authors.lastname: Bova
authors.forename: Anna Laura
authors.initials: AL
authors.lastname: Pasqui
authors.forename: Luca
authors.initials: L
authors.lastname: Puccetti
authors.forename: Alberto
authors.initials: A
authors.lastname: Auteri
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D018667:Tilt-Table Test; D014630:Vagus Nerve / Q000503:physiopathology; D014655:Vascular Resistance / Q000502:physiology*