[Antioxidant effect on the growth of Saccharopolyspora erythraea and biosynthesis of erythromycins].
Oxidative stress in the mycelium of submerged culture of S. erythraea, an organism producing erythromycins, was observed. The stress could be eliminated by addition of antioxidants, such as butyloxyanisole, alpha-tocopherol, cytochrome C to the culture. In the presence of the antioxidants the mycelium lysis decreased, the level of the decrease being higher in the medium preferably containing carbohydrates vs. the medium mainly containing lipids (soybean oil). The antioxidants had no specific effect on the biosynthesis of erythromycins.
Michurina
T A
TA
Sergeeva
A V
AV
Mironov
V A
VA
D000975:Antioxidants / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D003470:Culture Media; D045304:Cytochromes c / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D025282:Mycelium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D018384:Oxidative Stress; D016930:Saccharopolyspora / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D024502:alpha-Tocopherol / Q000494:pharmacology
D000975:Antioxidants; D003470:Culture Media; D002083:Butylated Hydroxyanisole; D004917:Erythromycin; D045304:Cytochromes c; D024502:alpha-Tocopherol