title: Prospective evaluation of quality of life after permanent prostate brachytherapy with I-125: importance of baseline symptoms and of prostate-V150.
abstract: OBJECTIVE
  Detailed knowledge of quality of life (QoL) after permanent I-125 brachytherapy may aid in counselling patients with early-stage prostate cancer.
  
  
  METHODS
  Seventy-four consecutive patients with low-risk prostate cancer were asked to complete the EORTC QLQ-C30 questionnaire with the prostate-specific PR25 module before implant, four weeks and one year after implant (response rates 97%, 88% and 89%, respectively). Implant characteristics were correlated with QoL scores.
  
  
  RESULTS
  Global QoL was stable from pre-treatment to one year after implant and similar to age-adjusted scores of healthy controls. Significant changes versus baseline in QLQ-C30 domains were worsened social function at four weeks, increased constipation at four weeks and at one year and improved emotional function at one year. PR25 urinary symptoms were significantly increased at four weeks and, despite some improvement, at one year; bowel symptoms were slightly increased. Both types of symptoms were most strongly related with pre-treatment symptom scores. Prostate-V150 was the only implant parameter significantly associated with both urinary and bowel symptoms at four weeks and one year.
  
  
  CONCLUSIONS
  Limiting the high-dose subvolume in the prostate may be beneficial to reduce urinary and bowel symptoms but the major determinant of symptoms after I-125 implant is the baseline symptom level.
authors.affiliation: Department of Radiation Oncology, University of Würzburg, Germany. vordermark_d@klinik.uni-wuerzburg.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Vordermark
authors.forename: Michael
authors.initials: M
authors.lastname: Noe
authors.forename: Klaus
authors.initials: K
authors.lastname: Markert
authors.forename: Jörn
authors.initials: J
authors.lastname: Wulf
authors.forename: Gerd
authors.initials: G
authors.lastname: Müller
authors.forename: Klaus
authors.initials: K
authors.lastname: Bratengeier
authors.forename: Gabriele
authors.initials: G
authors.lastname: Beckmann
authors.forename: Fabian
authors.initials: F
authors.lastname: Baier
authors.forename: Matthias
authors.initials: M
authors.lastname: Guckenberger
authors.forename: Frank
authors.initials: F
authors.lastname: Schiefelbein
authors.forename: Georg
authors.initials: G
authors.lastname: Schön
authors.forename: Michael
authors.initials: M
authors.lastname: Flentje
authors.forename: Kurt
authors.initials: K
authors.lastname: Baier
mesh_terms: D000368:Aged; D001918:Brachytherapy / Q000009:adverse effects*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000523:psychology* / Q000532:radiotherapy*; D011788:Quality of Life
chemical_list: D007457:Iodine Radioisotopes