[Advances on related genes with sexual precocity in mammals].
In mammals and humans, reproductive capacity is attained at puberty as the end-point of a complex series of developmental and neuroendocrine events that lead to true sexual maturity. As for humans, sexual precocity looks like a pathologic status. While for some animals, sexual precocity may be a valuable quantitative character. For some species, the character of sexual precocity was developed in the evolutionary process and stably transmitted to future generations. Sexual precocity is a complex character determined by polygenes. This review introduced the association between KiSS-1, GPR54, LHR, FSHR, CYP, ER, TGFa, IGF-, GNAS1, HSD3B2, SHBG, VDR genes and sexual precocity in mammals.
Chu
Ming-Xing
MX
Key Laboratory of Farm Animal Genetic Resources and Utilization of Ministry of Agriculture, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. mxchu@263.net
Feng
Tao
T
DI
Ran
R
Zhang
Bao-Yun
BY
Zhang
Ying-Jie
YJ
D000818:Animals; D019205:GTP-Binding Protein alpha Subunits, Gs / Q000235:genetics / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D011375:Progesterone Reductase / Q000235:genetics / Q000378:metabolism; D011629:Puberty, Precocious / Q000235:genetics / Q000378:metabolism; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D011962:Receptors, FSH / Q000235:genetics / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D012741:Sexual Maturation / Q000235:genetics*; D016211:Transforming Growth Factor alpha / Q000235:genetics / Q000378:metabolism
D011960:Receptors, Estrogen; D011962:Receptors, FSH; D043562:Receptors, G-Protein-Coupled; D016211:Transforming Growth Factor alpha; C533068:3 beta-hydroxysteroid dehydrogenase type II; D011375:Progesterone Reductase; D019205:GTP-Binding Protein alpha Subunits, Gs