[Effect of various factors on the biosynthesis of piscarinines, secondary metabolites of the fungus Penicillium piscarium westling].
Piscarinines A and B were synthesized most actively during the surface cultivation of the fungus Penicillium piscarium in a complex medium (5.5 mg/l). Under conditions of submerged cultivation in a mineral medium, the yield of piscarinines was two times lower. An increase in the inoculum quantity of conidia treated with Tween-80 increased the culture productivity. The biosynthesis of the alkaloid was completely suppressed when mannitol was replaced with glucose or when zinc, iron, or copper ions were added to the culture medium. The metabolites were active against the prostate cancer cell line LNCAP (IC50 were 2.195 and 1.914 microg/ml for piscarinines A and B, respectively).
Zhelifonova
V P
VP
Maier
A
A
Kozlovskiĭ
A G
AG
D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology; D010407:Penicillium / Q000254:growth & development* / Q000378:metabolism; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D011136:Polysorbates / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000188:drug therapy; D013501:Surface-Active Agents / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology
D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D008670:Metals; D011084:Polycyclic Aromatic Hydrocarbons; D011136:Polysorbates; D013501:Surface-Active Agents; D013549:Sweetening Agents; D008353:Mannitol; D005947:Glucose