title: Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation.
abstract: Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed with the use of the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118 (65%) of 182 patients. Number of abnormalities was predictive of outcome; more than 3 abnormalities was associated with inferior overall survival (OS; P < .03). Sites of recurrent aUPD were detected on 6p (n = 25), 16p (n = 22), 12q (n = 17), 1p36 (n = 14), 10q (n = 8), and 6q (n = 8). On multivariate analysis aUPD on 1p36 correlated with shorter OS (P = .05). aUPD on 16p was predictive of transformation (P = .03) and correlated with poorer progression-free survival (P = .02). aUPD is frequent at diagnosis of FL and affects probability of disease transformation and clinical outcome.
authors.affiliation: Centre for Medical Oncology, Barts and The London School of Medicine, London, United Kingdom. derville.oshea@cancer.org.uk
authors.forename: Derville
authors.initials: D
authors.lastname: O'Shea
authors.forename: Ciarán
authors.initials: C
authors.lastname: O'Riain
authors.forename: Manu
authors.initials: M
authors.lastname: Gupta
authors.forename: Rachel
authors.initials: R
authors.lastname: Waters
authors.forename: Youwen
authors.initials: Y
authors.lastname: Yang
authors.forename: David
authors.initials: D
authors.lastname: Wrench
authors.forename: John
authors.initials: J
authors.lastname: Gribben
authors.forename: Andreas
authors.initials: A
authors.lastname: Rosenwald
authors.forename: German
authors.initials: G
authors.lastname: Ott
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Rimsza
authors.forename: Harald
authors.initials: H
authors.lastname: Holte
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Cazier
authors.forename: Nathalie A
authors.initials: NA
authors.lastname: Johnson
authors.forename: Elias
authors.initials: E
authors.lastname: Campo
authors.forename: Wing C
authors.initials: WC
authors.lastname: Chan
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Young
authors.forename: Louis M
authors.initials: LM
authors.lastname: Staudt
authors.forename: T Andrew
authors.initials: TA
authors.lastname: Lister
authors.forename: Jude
authors.initials: J
authors.lastname: Fitzgibbon
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004252:DNA Mutational Analysis; D018572:Disease-Free Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D019656:Loss of Heterozygosity; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000401:mortality*; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D024182:Uniparental Disomy / Q000235:genetics*