[Genetic aspects of hypertensive effect of lead].
Lead (Pb) induces arterial hypertension in consequence of low exposures, which is not manifested by Pb toxic effects on the marrow, kidneys or other organs. Pb hypertensive effect, in the range of blood concentration from 10 to 40 microg/dl, has been evidenced by numerous experimental and population studies. However, the presence of significant correlation between blood lead level and systolic and/or diastolic blood pressure is not confirmed by some epidemiological studies. These discrepancies can be explained by the observation, that Pb-induced hypertension results rather from past than from current exposure, hence the arterial pressure values should be rather related to bone than to blood lead level. The occurrence of polymorphism of genes involved in Pb toxic effect may be another explanation. The interaction between Pb toxicity and ALAD gene polymorphisms on hematopoesis is observed in workers occupationally exposed to lead. These polymorphisms, occurring in a single form or in connection with other polymorphisms, seem to be implicated in Pb-induced hypertension, e.g., vitamin D receptor gene. The results of experimental studies show that the correlation between Pb exposure, arterial blood pressure and the presence of polymorphisms of angiotensin converting enzyme and beta(2)adrenergic receptor genes should be analysed in populations. It is likely that studies of other genes polymorphisms, genegene interactions and the interaction between genes and--environmental factors lead to the identification of causes of so called spontaneous hypertension.
Skoczyńska
Anna
A
Katedra i Klinika Chorób Wewnetrznych, Zawodowych i Nadciśnienia Tetniczego, Akademia Medyczna im. Piastów Slaskich, Wrocław. annaskoc@ak.am.wroc.pl
D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000633:toxicity; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000235:genetics*; D007855:Lead Poisoning / Q000150:complications / Q000235:genetics*; D016273:Occupational Exposure; D011110:Polymorphism, Genetic
D004785:Environmental Pollutants