[Stability of physical state on compound hawthorn dropping pills].
OBJECTIVE
To evaluate the stability of physical state with accelerate test and dropping in process before and after on compound hawthorn dropping pills.


METHODS
Scanning electron microscope, TG-DTA, FT-IR and XRD were used.


RESULTS
The active components presented amorphous, tiny crystal and molecular state in dropping pills, and it had no obvious reaction between PEG 4000 and active components. With time prolonging, a little of active components changed from amorphous state to tiny crystal or molecular state.


CONCLUSIONS
Solid dispersion improved the stability and dissolution of compound hawthorn dropping pills.
Zhang
Wei
W
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Chen
Hong-Yan
HY
Jiang
Jian-Lan
JL
D027825:Crataegus / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
D004365:Drugs, Chinese Herbal