title: Reconstituting a human brain in animals: a Jewish perspective on human sanctity.
abstract: The potential use of stem cells in the treatment of a variety of human diseases has been a major driving force for embryonic stem cell research. Another productive area of research has been the use of human stem cells to reconstitute human organ systems in animals in an attempt to create new animal models for human diseases. However, the possibility of transplanting human embryonic brain cells or precursor brain cells into an animal fetus presents numerous ethical challenges. This paper examines, from a Jewish perspective on human dignity, several bioethical concerns related to the reconstitution of animal brains with human neurons.
authors.affiliation: Department of Physiology and Cellular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Loike
authors.forename: Moshe
authors.initials: M
authors.lastname: Tendler
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology*; D016380:Brain Tissue Transplantation; D002678:Chimera; D032981:Dehumanization; D004195:Disease Models, Animal; D033041:Embryo Research / Q000941:ethics*; D053595:Embryonic Stem Cells; D032984:Ethics, Research; D040821:Human Characteristics; D006806:Human Rights; D006801:Humans; D007599:Judaism; D013045:Species Specificity