Cumulative and after-effects of short and weak coordinated reset stimulation: a modeling study.
We show that the dynamical multistability of a network of bursting subthalamic neurons, caused by synaptic plasticity has a strong impact on the stimulus-response properties when exposed to weak and short desynchronizing stimuli. Intriguingly, such stimuli can reliably shift the network from a stable state with pathological synchrony and connectivity to a stable desynchronized state with down-regulated connectivity. However, unlike in the case of stronger coordinated reset stimulation, after termination of weaker stimulation the network may undergo a transient rebound of synchrony. When the coordinated reset stimulation is even weaker and/or shorter, so that a single stimulation epoch is not effective, the network dynamics and connectivity can still be reshaped in a cumulative manner by repetitive stimulation delivery.
Hauptmann
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Institute of Neuroscience and Biophysics 3, Medicine and Virtual Institute of Neuromodulation, Research Center Jülich, Leo-Brandt-Str., D-52425 Jülich, Germany. c.hauptmann@fz-juelich.de
Tass
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D000200:Action Potentials; D000465:Algorithms; D004558:Electric Stimulation; D006801:Humans; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology*; D020531:Subthalamic Nucleus / Q000502:physiology; D013569:Synapses / Q000502:physiology