[Blood anticoagulation system in the hypercoagulation syndrome in patients with pulmonary tuberculosis].
The authors determined the state of the hemostatic system, the duration of fibrinolysis, intravascular coagulation (IVC) markers, and anticoagulation system activity by the values of antithrombin III (AIII), protein C (PC) and protein S (PS), as well as the depth of systemic inflammation by the values of acute phase reagents. Patients with pulmonary tuberculosis were found to have a hypercoagulation shift associated with prolonged fibrinolysis and accompanied by IVC. There was concurrently a decrease in the activity of the prothrombin complex and the D-dimers arising from IVC began to act as secondary anticoagulants. The hypercoagulation shift is attended by a moderate rise in the activity of AIII and PC with a simultaneous decrease in PS. As systemic inflammation and hypercoagulation syndrome progress, there is a gradual decompensation of the anticoagulation system. The changes in the values of prothrombin index, AIII, and PC are directly and inversely related to the degree of the hypercoagulation syndrome and systemic inflammation. PS showed no correlations.
Kaminskaia
G O
GO
Martynova
E V
EV
Serebrianaia
B A
BA
Komissarova
O G
OG
D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation / Q000502:physiology*; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications; D005176:Factor XIII / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011516:Prothrombin / Q000378:metabolism; D011517:Prothrombin Time; D012720:Severity of Illness Index; D013577:Syndrome; D013918:Thrombin Time; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000150:complications; D055815:Young Adult
D011516:Prothrombin; D005340:Fibrinogen; D005176:Factor XIII