Bioactive constituents from Chinese natural medicines. XXXIII. Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages.
The methanolic extract from the seeds of Psoralea corylifolia was found to inhibit production of nitric oxide (NO) in lipopolysaccharide-activated mouse peritoneal macrophages. Among the isolated compounds, bavachinin (IC(50)=26 microM), isobavachalcone (17 microM), neobavaisoflavone (ca. 29 microM), corylifol A (ca. 21 microM), and psoralidin (ca. 23 microM) significantly inhibited the accumulation of nitrite (NO(2)(-)) as a marker of production of NO. Bakuchiol, which is mainly contained in the extract, also showed weak activity at 10 microM, but cytotoxic effects were observed more than 30 microM.
Matsuda
Hisashi
H
Kyoto Pharmaceutical University, Japan.
Kiyohara
Sachie
S
Sugimoto
Sachiko
S
Ando
Shin
S
Nakamura
Seikou
S
Yoshikawa
Masayuki
M
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism*; D012639:Seeds / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D008070:Lipopolysaccharides; D009569:Nitric Oxide