title: Rotavirus-associated encephalopathy with a reversible splenial lesion.
abstract: The case is reported of a 2-year-old boy with a rotavirus-induced mild encephalopathy that presented as transient intensified signal on the splenium of the corpus callosum. The boy also experienced persistent diarrhea, vomiting, fever, and sudden disturbance of consciousness. Although cerebrospinal fluid analysis did not manifest pleocytosis, electroencephalography demonstrated global diffuse slow waves and cranial magnetic resonance imaging demonstrated intensified signal on the splenium of the corpus callosum. Methylprednisolone was infused for 3 days. The disturbance of consciousness disappeared within 24 hours without any other complications, and the splenial signal and electroencephalogram returned to normal within 6 days.
authors.affiliation: Department of Pediatrics, Shimane University School of Medicine, Izumuo, Shimane, Japan. sfukuda@med.shimane-u.ac.jp <sfukuda@med.shimane-u.ac.jp>
authors.forename: Seiji
authors.initials: S
authors.lastname: Fukuda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Kishi
authors.forename: Kenji
authors.initials: K
authors.lastname: Yasuda
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sejima
authors.forename: Seiji
authors.initials: S
authors.lastname: Yamaguchi
mesh_terms: D001927:Brain Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D002675:Child, Preschool; D003244:Consciousness Disorders / Q000188:drug therapy; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D004569:Electroencephalography; D006801:Humans; D007964:Leukocytosis / Q000134:cerebrospinal fluid / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008874:Midazolam / Q000627:therapeutic use; D012400:Rotavirus Infections / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D008874:Midazolam; D008775:Methylprednisolone