Bloodstream yeast infections: a 15-month survey.
A 15-month survey of 412 bloodstream yeast isolates from 54 Belgian hospitals was undertaken. Candida albicans was the most common species (47.3%) followed by C. glabrata (25.7%), C. parapsilosis (8.0%), C. tropicalis (6.8%) and Saccharomyces cerevisiae (5.1%). Common predisposing factors were antibacterial therapy (45%), hospitalization in intensive care units (34%), presence of in-dwelling catheters (32%), underlying cancer (23%) and major surgery (11%). Most patients had more than one predisposing factor. Fluconazole alone or in combination with another antifungal agent was the treatment of choice for 86.6% of the cases. Susceptibility testing revealed that 93.5% were susceptible to amphotericin B, 39.6% to itraconazole, 42.8% to fluconazole and 87% to voriconazole. Resistance to azoles was more common among C. glabrata isolates.
Swinne
D
D
Mycology Section, Scientific Institute of Public Health, Brussels, Belgium. dswinne@iph.fgov.be
Nolard
N
N
VAN Rooij
P
P
Detandt
M
M
D000935:Antifungal Agents / Q000627:therapeutic use; D001530:Belgium / Q000453:epidemiology; D016469:Fungemia / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D012307:Risk Factors; D015003:Yeasts
D000935:Antifungal Agents