title: Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog.
abstract: An 11-year-old Shih Tzu presented with crusting and erythema, mainly on the abdomen and the root of the tail. Based on histopathological findings, blood examinations and necropsy findings, the condition was diagnosed as superficial necrolytic dermatitis associated with a glucagon-secreting extrapancreatic neuroendocrine tumour. Gross necropsy revealed tumour invasion into the spleen, liver, adrenal glands and mesenteric lymph nodes. Immunohistochemical analysis of the neoplastic cells revealed that the tumour was a glucagonoma, consistent with earlier findings of persistent glucagonaemia and hypoaminoacidaemia.
authors.affiliation: Laboratory of Veterinary Internal Medicine, Yamaguci University, Yamaguchi, Japan. mizutaku@yamaguchi-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Mizuno
authors.forename: Hiroko
authors.initials: H
authors.lastname: Hiraoka
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yoshioka
authors.forename: Yoshiho
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Matsukane
authors.forename: Natsumi
authors.initials: N
authors.lastname: Shimoyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Morimoto
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Hayashi
authors.forename: Masaru
authors.initials: M
authors.lastname: Okuda
mesh_terms: D000818:Animals; D003872:Dermatitis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005935:Glucagonoma / Q000150:complications / Q000662:veterinary*; D008297:Male