Synoviorthesis in haemophilia patients with inhibitors.
Recurrent bleeding into joints represents the clinical hallmark of haemophilia and, if not adequately treated, it may cause chronic synovitis and degenerative arthropathy. In haemophilia patients with inhibitors, a more severe degree of synovitis is often observed owing to the fact that treatment is more problematic in this setting. The first treatment option of recurrent haemarthroses and/or chronic synovitis is represented by synoviorthesis, both chemical and radioisotopic, with a success rate of approximately 80% for both. However, radioisotopic synoviorthesis should be preferred in inhibitor patients because it makes it possible to obtain complete synovial fibrosis usually in one session, without the need for repeated injections, thus reducing the risk of bleeding complications and concentrate consumption. For all these reasons this procedure should be implemented and supported, particularly in developing countries.
Pasta
G
G
Traumatology Department and Angelo Bianchi Bonomi Haemophilia Centre, IRCCS Maggiore Hospital Foundation, Milan, Italy. gianluigipasta@yahoo.it
Mancuso
M E
ME
Perfetto
O S
OS
Solimeno
L P
LP
D000293:Adolescent; D000328:Adult; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood; D002648:Child; D002675:Child, Preschool; D006395:Hemarthrosis / Q000150:complications / Q000188:drug therapy; D006467:Hemophilia A / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007270:Injections, Intra-Articular / Q000379:methods; D011868:Radioisotopes; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D012293:Rifampin / Q000627:therapeutic use*; D013585:Synovitis / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult
D000904:Antibiotics, Antitubercular; D019774:Blood Coagulation Factor Inhibitors; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012293:Rifampin