title: Aspergillus flavus keratomycosis in a cat treated with topical 1% voriconazole solution.
abstract: An 8-year-old male castrated Domestic Short-haired cat was examined for a 1-week history of blepharospasm and mucoid ocular discharge OS. Examination revealed ulcerative keratitis with stromal loss, stromal infiltrate, corneal edema, perilimbal vascularization and miosis. Cytology of the cornea revealed multiple dichotomously branching, septate fungal hyphae and severe, predominantly neutrophilic inflammation. PCR of the cytology samples confirmed the presence of Aspergillus flavus while fungal and bacterial cultures were negative. Treatment with topical 1% voriconazole solution was successful in resolving the keratomycosis.
authors.affiliation: Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA. alabelle@uiuc.edu
authors.forename: Amber L
authors.initials: AL
authors.lastname: Labelle
authors.forename: Ralph E
authors.initials: RE
authors.lastname: Hamor
authors.forename: Anne M
authors.initials: AM
authors.lastname: Barger
authors.forename: Carol W
authors.initials: CW
authors.lastname: Maddox
authors.forename: Carrie B
authors.initials: CB
authors.lastname: Breaux
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000662:veterinary*; D001231:Aspergillus flavus / Q000302:isolation & purification*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000662:veterinary*; D007634:Keratitis / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole