title: [Determination of lactose intolerance frequency in children with food allergy].
abstract: Lactose malabsorption and lactose intolerance symptoms are the most common alimentary tract disorders in children. Lactose intolerance is a result of lactase deficiency or lack of lactase and lactose malabsorption. Hypersensitivity in food allergy is connected with the presence of specific IgE (specific antibodies against some allergens) or lymphocytes. Lactose intolerance and food allergy may coexist in the same patient.
  
  
  OBJECTIVE
  The aim of this study was determination of lactose intolerance frequency in children with food allergy who were below and above 5 years of age.
  
  
  METHODS
  The number of 87 children with food allergy aged from 0.7 to 18 years were included in the study (48 boys and 39 girls). 51 patients above 5 years of age and 36 patients below 5 years of age were studied. Lactose intolerance symptoms, hydrogen breath test, activity of lactase and villous atrophy were investigated.
  
  
  RESULTS
  Decreased absorption of lactose in hydrogen breath test was observed in 28% of children above 5 years of age and in 5% in younger children. Positive result of biological trial in hydrogen breath test was observed in 10% of patients who were below 5 years of age and in 26% patients above 5 years. There was no statistically significant difference in lactose intolerance frequency and in decreased activity of lactase in intestinal mucosa between these two groups. Frequent partial villous atrophy was observed in younger patients (41,38%) than in children above 5 years of age (17.86%).
  
  
  CONCLUSIONS
  Lactose intolerance was observed in 10% patients who were below 5 years of age and in 26% patients above 5 years of age with food allergy. There was no statistically significant difference between these two groups.
authors.affiliation: Akademia Medyczna we Wrocławiu, II Katedra i Klinikia Pediatrii, Gastroenterologii i Zywienia. tomaszhutyra@wp.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Hutyra
authors.forename: Barbara
authors.initials: B
authors.lastname: Iwańczak
mesh_terms: D000293:Adolescent; D001284:Atrophy; D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D005512:Food Hypersensitivity / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007223:Infant; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D007785:Lactose / Q000378:metabolism; D007787:Lactose Intolerance / Q000175:diagnosis / Q000453:epidemiology* / Q000378:metabolism; D008297:Male
chemical_list: D007785:Lactose