The secret life of Smad4.
Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.
Wrana
Jeffrey L
JL
Center for Systems Biology, Mount Sinai Hospital, Toronto M5G 1X5, Canada. wrana@lunenfeld.ca
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D051901:Smad4 Protein / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism; D043222:Ubiquitin Thiolesterase / Q000378:metabolism; D054875:Ubiquitination
D004268:DNA-Binding Proteins; D051901:Smad4 Protein; D016212:Transforming Growth Factor beta; D043222:Ubiquitin Thiolesterase