Synthesis of a Homologous Series of Side Chain Extended Orthogonally-Protected Aminooxy-Containing Amino Acids.
Practical methodology is reported for the synthesis of a homologous series of side chain extended amino acids containing aminooxy functionality bearing orthogonal protection suitable for Fmoc peptide synthesis. These reagents may be useful for the preparation of libraries containing fragments joined by peptide linkers.
Liu
Fa
F
Laboratory of Medicinal Chemistry, CCR, NCI-Frederick, NIH, Bldg. 376 Boyles St., Frederick, Maryland 21702, Fax 301-846-6033.
Thomas
Joshua
J
Burke
Terrence R
TR