title: [Characteristics and treatment of multiple organ dysfunction syndrome in patients with trauma in the Wenchuan earthquake on 12th May, 2008].
abstract: OBJECTIVE
  To analyze the characteristics and treatment of the multiple organ dysfunction syndrome (MODS) in patients in the Wenchuan earthquake on 12th May, 2008, in order to provide theoretical reference for future care for such patients.
  
  
  METHODS
  Characteristics of MODS in these patients were analyzed, differences between survivors and non-survivors were compared, and therapeutic measures, and the time of the treatment for MODS in patients with earthquake related injury or illness who were admitted to West China Hospital from 12th May to 20th June, 2008, were retrospectively analyzed.
  
  
  RESULTS
  A total of 42 MODS patients were admitted to intensive care unit (ICU). Both the acute physiology and chronic health evaluation II (APACHE II) score and predicted death risk were lowering during the course of therapy. Fractures of bones of extremities were predominant in the earthquake related diseases, with an incidence of 45.2%. The actual mortality of MODS (33.3%) was lower than the predicted death risk (41.5%). The age, the time of receiving the first treatment in ICU after the earthquake, the Glasgow score, the oxygen index, blood creatinine level, platelet count, and vasoactive agent pumping velocity were significantly different between survivors and non-survivors (all P<0.05). The overall mortality was 9.8%, the morbidity of cardiac dysfunction, the incidence of acute renal failure (ARF) and sepsis were significantly different between non-survivors and survivors (all P<0.05). The use of mechanical ventilation, continuous renal replacement therapy (CRRT), and vasoactive agent reached peak level on the 14-29 days after the earthquake.
  
  
  CONCLUSIONS
  Fracture of bones of extremities are predominant injury in the earthquake related diseases, and the cause of death is closely associated with multiple trauma and ARF, systemic infection of large wound surfaces. The central nervous system, respiratory system, circulatory system, renal function, circulatory system should be monitored during the treatment. Adequate preparedness is essential in order to cope with the peak period of occurrence of serious complications after a disaster.
authors.affiliation: Intensive Care Unit, West China Hospital, Si chuan University, Chengdu 610041, Sichuan, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Pu
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Jin
authors.forename: Yi-yun
authors.initials: YY
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Kang
authors.forename: Xiao-qi
authors.initials: XQ
authors.lastname: Xie
authors.forename: Xue-lian
authors.initials: XL
authors.lastname: Liao
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Cun-zhen
authors.initials: CZ
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D004190:Disasters; D055866:Earthquakes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D014947:Wounds and Injuries / Q000150:complications