Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis.
We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.
Saville
Stephen P
SP
Department of Biology and South Texas Center for Emerging Infectious Diseases, the University of Texas at San Antonio, San Antonio, Texas 78249, USA.
Lazzell
Anna L
AL
Chaturvedi
Ashok K
AK
Monteagudo
Carlos
C
Lopez-Ribot
Jose L
JL
D000818:Animals; D002176:Candida albicans / Q000235:genetics / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology / Q000517:prevention & control*; D005657:Fungal Vaccines / Q000235:genetics / Q000276:immunology*; D051379:Mice; D020890:Neuregulin-1 / Q000235:genetics / Q000276:immunology*; D016019:Survival Analysis; D013601:T-Lymphocytes / Q000276:immunology; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
D005657:Fungal Vaccines; D020890:Neuregulin-1; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic