title: [Radiotherapy of soft tissue sarcoma--part of a multidisciplinary strategy].
abstract: The management of soft tissue sarcoma has evolved from a solitary surgical treatment to an interdisciplinary multimodal approach including radiotherapy. These fundamental changes are the result of increased knowledge in tumor biology, radiation sensitivity and the improvement in modern radiation therapy techniques. A successful effective therapy regimen strongly depends on distinct preoperative diagnostics, preoperative conception of the surgical intervention and an experienced oncological team. Of significant importance for the prognosis is early diagnosis as well as tumor excision with a wide negative margin. However, even after complete wide resection in sano, the use of postoperative radiotherapy can further improve local control and should therefore be applied to the majority of patients. Consequently, radiotherapy should only be omitted in cases in which the tumor has been excised with a very wide negative margin; this implies, however, high quality of surgery and distinct histopathological analysis. Patients with non- or questionable resectable tumors, should be referred for pre-operative radiotherapy in order to improve the surgical results. Recent studies have underlined the efficiency of modern radiotherapy regimens. The different radiotherapy regimens will be highlighted against the background of tumor stage and tumor resectibility.
authors.affiliation: Department of Radiooncology, University of Düsseldorf, and Marien Hospital Düsseldorf, Germany.
authors.forename: Hildegard
authors.initials: H
authors.lastname: Pape
authors.forename: Klaus
authors.initials: K
authors.lastname: Orth
authors.forename: Rainer
authors.initials: R
authors.lastname: Engers
authors.forename: Christiane
authors.initials: C
authors.lastname: Matuschek
authors.forename: Anja
authors.initials: A
authors.lastname: Müller
authors.forename: Karl-Axel
authors.initials: KA
authors.lastname: Hartmann
authors.forename: Peter Arne
authors.initials: PA
authors.lastname: Gerber
authors.forename: Guido
authors.initials: G
authors.lastname: Lammering
authors.forename: Daniel
authors.initials: D
authors.lastname: Habermehl
authors.forename: Roland
authors.initials: R
authors.lastname: Fenk
authors.forename: Wilfried
authors.initials: W
authors.lastname: Budach
authors.forename: Stephan
authors.initials: S
authors.lastname: Gripp
authors.forename: Matthias
authors.initials: M
authors.lastname: Peiper
authors.forename: Edwin
authors.initials: E
authors.lastname: Bölke
mesh_terms: D001918:Brachytherapy; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D042241:Early Diagnosis; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010348:Patient Care Team; D011880:Radiotherapy Planning, Computer-Assisted; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery