When is a malaria immune complex not an immune complex?
Immune complexes (ICs) are believed to play an important role in malaria pathology, and an interesting article by Mibei et al. recently published by Parasite Immunology suggests that IgG4 and IgE are particularly important. However, researchers should be aware of potential pitfalls to current assays aimed at measuring plasma ICs and correlating these to deposition in tissues.
Pleass
R J
RJ
Institute of Genetics, Queen's Medical Centre, Nottingham, UK. richard.pleass@nottingham.ac.uk
D000740:Anemia / Q000097:blood / Q000276:immunology / Q000469:parasitology*; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000097:blood / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D016779:Malaria, Cerebral / Q000097:blood / Q000209:etiology / Q000276:immunology*; D010961:Plasmodium / Q000276:immunology*
D000913:Antibodies, Protozoan; D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007073:Immunoglobulin E