Glioblastoma multiforme in children: experience at Hospital Infantil de Mexico Federico Gomez.
OBJECTIVE
To evaluate clinical evolution of pediatric patients diagnosed with glioblastoma multiforme (GBM) at Hospital Infantil de México Federico Gómez.


METHODS
Cases of patients treated from January to May, 2007, were included in this study. Variables analyzed were: age, diagnosis, size of tumor, histopathological description, degree of resection, time of stay in hospital, complications and outcome using Pearson's chi-squared test and logistic regression.


CONCLUSIONS
Sixteen patients were identified. Mean age of presentation was 8.8. An increased frequency of complications was observed in younger patients and longer survival rates in patients with greater resections; main mode of presentation was directly related to intracranial hypertension; size of tumor was not related to evolution or outcome. Modern histological classifications especially designed for children are deemed necessary to accurately diagnose GBM.
Sánchez-Herrera
Federico
F
Department of Neurosurgery, Hospital Infantil de México Federico Gómez, 06720 Mexico, D.F., Mexico.
Castro-Sierra
Eduardo
E
Gordillo-Domínguez
Luis Felipe
LF
Vaca-Ruiz
Miguel Angel
MA
Santana-Montero
Blanca
B
Perezpeña-Diazconti
Mario
M
González-Carranza
Vicente
V
Torres-García
Samuel
S
Chico-Ponce de León
Fernando
F
D000367:Age Factors; D001932:Brain Neoplasms / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D016009:Chi-Square Distribution; D002648:Child; D005260:Female; D005909:Glioblastoma / Q000150:complications* / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D006776:Hospitals, Pediatric; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology* / Q000503:physiopathology; D016015:Logistic Models; D008297:Male; D008800:Mexico; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate