title: Biology of myospryn: what's known?
abstract: Myospryn (CMYA5, cardiomyopathy-associated 5) is a muscle-specific member of the TRIM superfamily, discovered a few years ago. Properties and functions of the little-studied protein remain largely enigmatic, but identified interactions have suggested that myospryn is involved in two seemingly distinct processes, protein kinase A signalling and vesicular trafficking. Recent findings have implicated myospryn in Duchenne muscular dystrophy and cardiac disease, making it an exciting new player in the field of muscle biology and pathology.
authors.affiliation: Folkhälsan Institute of Genetics and Department of Medical Genetics, University of Helsinki, Helsinki, Finland. jaakko.sarparanta@helsinki.fi
authors.forename: Jaakko
authors.initials: J
authors.lastname: Sarparanta
mesh_terms: D000818:Animals; D009202:Cardiomyopathies / Q000201:enzymology / Q000235:genetics / Q000378:metabolism; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D022162:Cytoplasmic Vesicles / Q000378:metabolism; D006801:Humans; D009124:Muscle Proteins / Q000737:chemistry* / Q000502:physiology*; D020388:Muscular Dystrophy, Duchenne / Q000201:enzymology / Q000378:metabolism; D021381:Protein Transport; D015398:Signal Transduction / Q000502:physiology
chemical_list: C430866:CMYA5 protein, human; D009124:Muscle Proteins; D017868:Cyclic AMP-Dependent Protein Kinases