Highly enantioselective conjugate additions of aldehydes to vinyl sulfones.
Joined together, organocatalysts aldehydes and sulfones: A diaryl prolinol silyl ether was found to catalyse efficiently and enantioselectively the conjugate addition of aldehydes to vinyl sulfones (see scheme). The ample synthetic utility of the resulting adducts is illustrated.
Landa
Aitor
A
Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain.
Maestro
Miguel
M
Masdeu
Carme
C
Puente
Angel
A
Vera
Silvia
S
Oiarbide
Mikel
M
Palomo
Claudio
C