title: Mice are not susceptible to hepatitis E virus infection.
abstract: To determine whether or not mice are susceptible to hepatitis E virus (HEV) infection, C57BL/6 mice were experimentally infected with genotypes 1, 3 and 4 HEV by intravenous injection. Serum and stool samples were collected and used to detect HEV RNA and anti-HEV antibodies by RT-PCR and ELISA. The virus infection was monitored up to two months after inoculation; however, none of the serum or stool samples was positive for virus replication, demonstrating that C57BL/6 mice were not susceptible to HEV.
authors.affiliation: Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan. litc@nih.go.jp
authors.forename: Tian-Cheng
authors.initials: TC
authors.lastname: Li
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Suzaki
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ami
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsunemitsu
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Miyamura
authors.forename: Naokazu
authors.initials: N
authors.lastname: Takeda
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D004198:Disease Susceptibility / Q000821:virology*; D016751:Hepatitis E; D016752:Hepatitis E virus / Q000276:immunology*; D008252:Macaca fascicularis / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D000914:Antibodies, Viral