[Frequency of micronuclei in erythrocytes of mice subchronic exposed to ionising radiation and nonylphenol].
The aim of the research was to investigate the level of micronuclei induction in reticulocytes and polychromatic erythrocytes of mice following subchronic exposure to X-rays, nonylphenol (NP) or to a combination of both. Male mice Pzh:SFIS were exposed during 8 weeks, 5 day per week to doses 0.05 Gy and 0.10 Gy of X-rays, 25 mg/kg mc and 50 mg/kg bw of nonylphenol as well as to 0.05 Gy + 25 mg/kg bw NP and 0.10 Gy + 50 mg/kg bw NP for combined exposure. Both X-rays and NP, acting alone induced micronuclei in reticulocytes and in polychromatic erythrocytes of mice. Combined X-rays-NP exposure of peripheral blood reticulocytes and bone marrow polychromatic erythrocytes caused enhanced frequency of micronuclei compared to the effect of each agent alone. In bone marrow reticulocytes, combined exposure in lower doses (0.05 Gy + 25 mg/kg bw NP) induced enhanced mutagenic effect. Contrary, after combined exposure to both agents in higher doses (0.10 Gy + 50 mg/kg bw NP), nonylphenol may protected DNA of reticulocytes against damage induced by X-rays.
Dobrzyńska
Małgorzata M
MM
Zakład Ochrony Radiologicznej i Radiobiologii, Narodowy Instytut Zdrowia Publicznego - Państwowy Zakład Higieny, 00-791 Warszawa, ul. Chocimska 24. mdobrzynska@pzh.gov.pl
D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000528:radiation effects / Q000633:toxicity; D010636:Phenols / Q000633:toxicity*; D013997:Time Factors; D014916:Whole-Body Irradiation; D014965:X-Rays / Q000009:adverse effects*
D009153:Mutagens; D010636:Phenols; C025256:nonylphenol