title: Molecular fields in drug discovery: getting old or reaching maturity?
abstract: With GRID first published 23 years ago, and CoMFA 20 years ago, the two most widely known methods that apply molecular fields to drug discovery are now into their third decade. Are molecular-field-based methods still applicable to modern drug discovery? Are they old and outdated? Or are they maturing into their full potential?
authors.affiliation: Molecular Discovery Limited, 215 Marsh Road, Pinner, Middlesex, London HA5 5NE, United Kingdom. Simon@moldiscovery.com
authors.forename: Simon
authors.initials: S
authors.lastname: Cross
authors.forename: Gabriele
authors.initials: G
authors.lastname: Cruciani
mesh_terms: D003198:Computer Simulation; D017076:Computer-Aided Design; D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008958:Models, Molecular; D021281:Quantitative Structure-Activity Relationship