title: Chronic myeloid leukaemia in two multiple sclerosis patients on interferon beta-1a.
abstract: Haematological problems are commonly associated with use of beta-interferon in multiple sclerosis (MS) patients. However these problems are usually benign and are reversible when the drug is stopped. We describe two patients, with the diagnosis of MS, who developed leucocytosis. Cytogenetic studies showed the presence of the Philadelphia chromosome in all the cells analysed, confirming the diagnosis of chronic myeloid leukaemia (CML). The first patient currently on imatimib mesylate and interferon beta-1a is asymptomatic. For the second patient, interferon beta-1a was withdrawn after suspicion of CML.
authors.affiliation: Division of Neurology and Epidemiology and Department of Medicine - Federal University of Bahia, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Almeida
authors.forename: M
authors.initials: M
authors.lastname: Neves
authors.forename: E
authors.initials: E
authors.lastname: Cardoso
authors.forename: A
authors.initials: A
authors.lastname: Melo
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000139:chemically induced*; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy*
chemical_list: D000276:Adjuvants, Immunologic; D016899:Interferon-beta; D000068556:Interferon beta-1a