title: Papillomavirus DNA replication - from initiation to genomic instability.
abstract: Papillomaviruses establish their productive life cycle in stratified epithelium or mucosa, where the undifferentiated proliferating keratinocytes are the initial targets for the productive viral infection. Papillomaviruses have evolved mechanisms to adapt to the normal cellular growth control pathways and to adjust their DNA replication and maintenance cycle to contend with the cellular differentiation. We provide overview of the papillomavirus DNA replication in the differentiating epithelium and describe the molecular interactions important for viral DNA replication on all steps of the viral life cycle.
authors.affiliation: Institute of Technology, University of Tartu, Estonia.
authors.forename: Meelis
authors.initials: M
authors.lastname: Kadaja
authors.forename: Toomas
authors.initials: T
authors.lastname: Silla
authors.forename: Ene
authors.initials: E
authors.lastname: Ustav
authors.forename: Mart
authors.initials: M
authors.lastname: Ustav
mesh_terms: D004261:DNA Replication; D004279:DNA, Viral / Q000235:genetics; D016679:Genome, Viral; D042822:Genomic Instability; D027383:Papillomaviridae / Q000235:genetics* / Q000502:physiology; D030361:Papillomavirus Infections / Q000821:virology; D014779:Virus Replication
chemical_list: D004279:DNA, Viral