Base-pairing directed folding of a bimolecular G-quadruplex: new insights into G-quadruplex-based DNAzymes.
Base pairs, magic hands: An additional base-pairing duplex is utilized to control the folding topologies of a bimolecular G-quadruplex formed by two G-rich single-stranded DNAs (see picture), which is dependent on the position of base pairs. This study clearly reveals an important intrinsic role of additional base pairs in the G-quadruplex structure, and also provides a clue to the formation mechanism of the G-quadruplex-based DNAzyme.
Li
Tao
T
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, China.
Wang
Erkang
E
Dong
Shaojun
S
D000465:Algorithms; D052157:Aptamers, Nucleotide / Q000737:chemistry; D020029:Base Pairing; D001483:Base Sequence; D021881:DNA, Catalytic; D004277:DNA, Single-Stranded / Q000737:chemistry*; D054856:G-Quadruplexes; D006427:Hemin / Q000737:chemistry*; D008958:Models, Molecular; D013056:Spectrophotometry, Ultraviolet
D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D004277:DNA, Single-Stranded; D006427:Hemin