Diffuse optical tomography of the breast: preliminary findings of a new prototype and comparison with magnetic resonance imaging.
This paper presents an evaluation of a prototype diffuse optical tomography (DOT) system. Seventeen women with 18 breast lesions (10 invasive carcinomas, 2 fibroadenomas, and 6 benign cysts; diameters 13-54 mm) were evaluated with DOT and magnetic resonance imaging (MRI). A substantial fraction of the original 36 recruited patients could not be examined using this prototype due to technical problems. A region of interest (ROI) was drawn at the lesion position as derived from MRI and at the mirror image site in the contralateral healthy breast. ROIs were assessed quantitatively and qualitatively by two observers independently in two separate readings. Intra- and interobserver agreements were calculated using kappa statistics (k) and intraclass correlation coefficients (ICCs). Discriminatory values for presence of malignancy were determined by receiver operating characteristic (ROC) analyses. Intraobserver agreements were excellent (k 0.88 and 0.88; ICC 0.978 and 0.987), interobserver agreements were good to excellent (k 0.77-0.95; ICC 0.96-0.98). Discriminatory values for presence of malignancy were 0.92-0.93 and 0.97-0.99 for quantitative and qualitative ROC analysis, respectively. This DOT system has the potential to discriminate malignant from benign breast tissue in a reproducible qualitative and quantitative manner. Important technical improvements are required before this technique is ready for clinical application.
van de Ven
Stephanie M W Y
SM
Department of Radiology, University Medical Center Utrecht, E.01.132, Heidelberglaan 100, PO Box 85500, 3508 GA Utrecht, The Netherlands. s.m.w.y.vandeven-2@umcutrecht.nl
Elias
Sjoerd G
SG
Wiethoff
Andrea J
AJ
van der Voort
Marjolein
M
Nielsen
Tim
T
Brendel
Bernhard
B
Bontus
Claas
C
Uhlemann
Falk
F
Nachabe
Rami
R
Harbers
Rik
R
van Beek
Michiel
M
Bakker
Leon
L
van der Mark
Martin B
MB
Luijten
Peter
P
Mali
Willem P Th M
WP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D015588:Observer Variation; D010363:Pattern Recognition, Automated; D011446:Prospective Studies; D012372:ROC Curve; D041622:Tomography, Optical / Q000379:methods*