title: Funding of Parkinson research from industry and US federal and foundation sources.
abstract: Funding for biomedical and neuroscience research has increased over the last decade but without a concomitant increase in new therapies. This study's objectives were to determine the level and principal sources of recent funding for Parkinson disease (PD) research and to determine the current state of PD drug development. We determined the level and principal sources of recent funding for PD research from the following sources: US federal agencies, large PD foundations based in the United States, and global industry. We assessed the status of PD drug development through the use of a proprietary drug pipeline database. Funding for PD research from the sources examined was approximately $1.1 billion in 2003 and $1.2 billion in 2005. Industry accounted for 77% of support from 2003 to 2005. The number of drugs in development for PD increased from 67 in 2003 to 97 in 2007. Of the companies with at least one compound in development for PD in 2007, most were small (62% had annual revenue of less than $100 million), and most (53%) were based outside the United States. These companies will likely require partnerships to drive successful development of new PD therapies.
authors.affiliation: Department of Neurology, University of Rochester Medical Center, Rochester, New York 14620, USA. ray.dorsey@ctcc.rochester.edu
authors.forename: E Ray
authors.initials: ER
authors.lastname: Dorsey
authors.forename: Joel P
authors.initials: JP
authors.lastname: Thompson
authors.forename: Mark
authors.initials: M
authors.lastname: Frasier
authors.forename: Todd
authors.initials: T
authors.lastname: Sherer
authors.forename: Brian
authors.initials: B
authors.lastname: Fiske
authors.forename: Sean
authors.initials: S
authors.lastname: Nicholson
authors.forename: S Claiborne
authors.initials: SC
authors.lastname: Johnston
authors.forename: Robert G
authors.initials: RG
authors.lastname: Holloway
authors.forename: Hamilton
authors.initials: H
authors.lastname: Moses
mesh_terms: D035843:Biomedical Research / Q000191:economics*; D055808:Drug Discovery / Q000191:economics / Q000379:methods; D004345:Drug Industry / Q000191:economics*; D005380:Financing, Government / Q000191:economics*; D006801:Humans; D010300:Parkinson Disease / Q000191:economics*; D012109:Research Support as Topic / Q000191:economics*; D014481:United States