The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges.
The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.
Abate-Shen
Cory
C
Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. cabateshen@columbia.edu
Brown
Powel H
PH
Colburn
Nancy H
NH
Gerner
Eugene W
EW
Green
Jeffery E
JE
Lipkin
Martin
M
Nelson
William G
WG
Threadgill
David
D
D000818:Animals; D018890:Chemoprevention / Q000379:methods*; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods* / Q000639:trends; D004526:Efficiency; D016147:Genes, Tumor Suppressor; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000517:prevention & control*