title: Conference on "Multidisciplinary approaches to nutritional problems". Postgraduate Symposium. The role of fat in gastric emptying and satiety: acute and chronic effects.
abstract: Dietary fat is an important factor in the aetiology of obesity and the metabolic syndrome. It has been widely debated whether gastric emptying (GE) is altered in obesity. GE times have been reported as both longer and shorter in obese individuals compared with matched lean individuals. However, the general consensus is that GE is accelerated and satiety is lower in obesity. Research has implicated a high-fat (HF) diet in these findings. A single HF meal has a longer GE time than a low-fat meal and can even delay GE of the subsequent meal. However, an HF diet has shown different effects. Feeding a HF diet adapts gastrointestinal function to reduce GE times in comparison with a low-fat diet. Increased GE may lead to decreased satiety and faster onset of subsequent eating episodes. Further results have suggested that consuming an HF diet for 14 d increases the GE rate of HF food but not low-fat food. Consuming HF diets for 2 weeks has also been shown to increase food intake. Decreased satiation following an HF diet may cause increased food intake and a positive energy balance, potentially resulting in a gradual increase in adiposity. Recent results have suggested that gastrointestinal transit is accelerated following only 3 d on a HF diet. The variable GE times reported in obesity may be associated with interactions between the HF diet and obesity and not simply the obese state.
authors.affiliation: Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Republic of Ireland. miriamclegg@hotmail.com
authors.forename: Miriam
authors.initials: M
authors.lastname: Clegg
authors.forename: Amir
authors.initials: A
authors.lastname: Shafat
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D006963:Hyperphagia / Q000503:physiopathology; D008297:Male; D009765:Obesity / Q000209:etiology / Q000503:physiopathology; D012527:Satiation / Q000502:physiology*; D012727:Sex Characteristics; D014630:Vagus Nerve / Q000503:physiopathology
chemical_list: D004041:Dietary Fats