title: Characterizing Prostiva RF treatments of the prostate for BPH with gadolinium-enhanced MRI.
abstract: Transurethral needle ablation (TUNA) is an accepted and effective therapy for the treatment of lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH). Prostiva (Medtronic, Shoreview, MN) is the newest-generation device, which includes a new needle design and radio frequency (RF) generator. This device creates temperatures of 120 degrees C and necrotic lesions in less than 2.5 min. Using previously described techniques, we analyzed dynamic, gadolinium-enhanced MRIs to characterize the ablative properties of the new Prostiva RF device. Ten men with LUTS due to BPH were treated with the standard Prostiva manufacturer-recommended protocol. The bladder neck and lateral lobes received treatment based on prostate volume and prostatic urethral length. Gadolinium-enhanced MRI sequences were obtained prior to and 1 week post-treatment. Analyze software (Mayo Clinic Biomedical Imaging Resource, Rochester, MN) was used to evaluate MRIs. New gadolinium defects were seen in all patients following Prostiva treatments. All lesions coalesced within the prostate. No defects were seen beyond the prostate, and the urethra was spared in all patients. The mean volume of necrosis was 7.56 cc, representing a mean of 11.28% of total prostate volume. Dynamic, gadolinium-enhanced MRIs demonstrate new vascular defects representing necrosis caused by Prostiva RF therapy of the prostate. The standard Prostiva RF protocol produces lesions that coalesce to create larger lesions in the bladder neck and lateral lobes. Compared to the TUNA Precision Plus device, the ablative lesions appear comparable while produced with a shorter burn time.
authors.affiliation: Department of Urology, University of Chile, Santiago, Chile. christianhuidobro@gmail.com
authors.forename: Christian
authors.initials: C
authors.lastname: Huidobro
authors.forename: Benjamin
authors.initials: B
authors.lastname: Larson
authors.forename: Samuel
authors.initials: S
authors.lastname: Mynderse
authors.forename: James J
authors.initials: JJ
authors.lastname: Myers
authors.forename: David
authors.initials: D
authors.lastname: Busel
authors.forename: Cristian
authors.initials: C
authors.lastname: Acevedo
authors.forename: Thayne R
authors.initials: TR
authors.lastname: Larson
authors.forename: Lance A
authors.initials: LA
authors.lastname: Mynderse
mesh_terms: D017115:Catheter Ablation; D005682:Gadolinium; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D011470:Prostatic Hyperplasia / Q000473:pathology* / Q000601:surgery*
chemical_list: D005682:Gadolinium