Flucloxacillin induced acute renal failure.
BACKGROUND
Acute interstitial nephritis is a less frequently reported adverse effect of flucloxacillin compared with other well known associations such as hepatotoxicity.


OBJECTIVE
This article describes the conservative management of a case of flucloxacillin induced acute renal failure, and reviews the available evidence on the treatment of drug induced acute interstitial nephritis, including the use of corticosteroids.


CONCLUSIONS
Drug induced acute interstitial nephritis can be managed conservatively by cessation of the suspected offending drug in many cases. Referral should be made to a nephrologist, with consideration given to renal biopsy, followed by trial of corticosteroids, if renal function does not improve within 7 days of drug cessation.
Xu
Bo
B
Geriatric Evaluation and Management Unit, St Vincent's Hospital, Melbourne, Victoria. greatbear227@hotmail.com
Murray
Michael
M
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005436:Floxacillin / Q000009:adverse effects*; D006801:Humans; D008297:Male
D000900:Anti-Bacterial Agents; D005436:Floxacillin