Novel class of hybrid natural products as antidiabetic agents.
A number of O-alkylated xanthone, carbazoles and coumarins have been synthesised and screened for their in vitro anti-diabetic activity, such as glucose-6-phosphatase, glycogen phosphorylase and alpha glucosidase inhibitors. Compounds which were showing significant percentage inhibition were also tested for in vivo anti-hyperglycemic activity in sucrose loaded normal and streptozotocin (STZ)-induced diabetic rats. These compounds show 22.1, 24.4 and 26.7% and 20.8, 25.0, 20.5% lowering in sucrose loaded normal rats and STZ-induced diabetic rats at a dose of 100 mg kg(-1).
Raj
Kanwal
K
Medicinal & Process Chemistry Division, Central Drug Research Institute, Lucknow, India. kanwalraj12@rediffmail.com
Misra
Namita
N
Pachauri
Geetali
G
Sharma
Mithelesh
M
Tamrakar
Akhilesh Kumar
AK
Singh
Amar Bahadur
AB
Srivastava
Arvind Kumar
AK
Phani Kiran
K
K
Narasimha Rao
C V
CV
Prubhu
S R
SR
D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D024981:Glycogen Phosphorylase / Q000378:metabolism; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013311:Streptozocin / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology; D044004:Xanthones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D001688:Biological Products; D002227:Carbazoles; D003374:Coumarins; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D013729:Terpenes; D044004:Xanthones; D013311:Streptozocin; D024981:Glycogen Phosphorylase; D005952:Glucose-6-Phosphatase; C017719:solanesol