Language processing deficits in sickle cell disease in young school-age children.
Verbal IQ deficits are frequently reported for school-age children with sickle cell disease (SCD), yet the profile of language abilities in SCD is unclear. We examined semantic, syntactic, and phonological processing in five-to-seven-year-olds at high neurologic risk based on SCD subtype (N = 33), at low neurologic risk with SCD (N = 21), and without SCD (N = 54). Low-risk SCD did not show language processing deficits. High-risk SCD showed deficits in all three language domains. Language processing deficits in SCD at the start of middle childhood are related to neurologic risks and include language skills beyond vocabulary.
Schatz
Jeffrey
J
Departments of Psychology and Pediatrics, University of South Carolina, Columbia, 29205, USA. schatz@sc.edu
Puffer
Eve S
ES
Sanchez
Carmen
C
Stancil
Melita
M
Roberts
Carla W
CW
D000755:Anemia, Sickle Cell / Q000150:complications* / Q000523:psychology*; D017028:Caregivers / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000209:etiology*; D008297:Male; D015999:Multivariate Analysis; D009483:Neuropsychological Tests; D010287:Parent-Child Relations; D013223:Statistics as Topic; D011795:Surveys and Questionnaires