Value of CRP in coronary risk determination.
Initial studies showed that C-reactive protein (CRP) may have a role in the genesis of atherosclerotic lesions and as a novel biomarkers of patients at risk of developing coronary heart disease (CHD) events. Most of these studies had methodologic limitations, and recent data contradict these findings and suggest that inflammatory markers, such as CRP, have limited usefulness in the prediction of CHD events over and above conventional risk factors. Its low predictive value creates difficulty in interpreting the CRP data in an individual patient. Current scientific literature does not support measurement of CRP in individual patients in clinical medicine. In this review, we critically appraise role of CRP in cardiovascular medicine.
Mehta
Jawahar L
JL
Division of Cardiovascular Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205-7199, USA. MehtaJL@uams.edu
Sukhija
Rishi
R
Romeo
Francesco
F
Sepulveda
Jorge L
JL
D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis*; D003324:Coronary Artery Disease / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology*; D011379:Prognosis; D018570:Risk Assessment; D012307:Risk Factors
D015415:Biomarkers; D002097:C-Reactive Protein