Cascade palladium-catalyzed alkenyl aminocarbonylation/ intramolecular aryl amidation: an annulative synthesis of 2-quinolones.
Palladium-catalyzed intermolecular aminocarbonylation/intramolecular amidation cascade sequences can be used to convert a range of 2-(2-haloalkenyl)aryl halide substrates efficiently and selectively to the corresponding 2-quinolones. Delaying the introduction of the CO atmosphere allows an amination/carbonylation sequence and the preparation of an isoquinolone.
Tadd
Andrew C
AC
Department of Chemistry, University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford OX1 3TA, UK.
Matsuno
Ai
A
Fielding
Mark R
MR
Willis
Michael C
MC
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry
D006842:Hydrocarbons, Brominated; D007546:Isoquinolines; D015363:Quinolones; D010165:Palladium