Antiphospholipid antibodies from a patient with primary antiphospholipid syndrome enhance experimental atherosclerosis.
BACKGROUND
A 35-year-old man with primary antiphospholipid syndrome and no risk factors for atherosclerosis presented with postinfarction angina.


METHODS
Coronary angiography, intravascular ultrasonography, injection of apolipoprotein-E-knockout mice with patient's IgG.


METHODS
Myocardial infarction caused by a newly occluded proximal left circumflex artery. The left anterior descending artery exhibited a recanalized thrombus throughout the vessel.


RESULTS
The patient was managed by intensive angicoagulation including aspirin, clopidogrel, and enoxaparin for 2 months. After follow-up coronary angiography, he was switched to warfarin with a target International Normalized Ratio of 3.5-4.0.
Adler
Arnon
A
Department of Cardiology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.
Afek
Arnon
A
Levy
Yair
Y
Keren
Gad
G
George
Jacob
J
D000328:Adult; D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000276:immunology*; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D006801:Humans; D008297:Male; D051379:Mice; D018345:Mice, Knockout
D017152:Antibodies, Antiphospholipid