title: Effects of prenatal and neonatal cadmium intoxication on the intensity of lipid peroxidation and activity of glutathione system in progeny of albino rats.
abstract: Oral treatment of pregnant or lactating rats with Cd(NO3)2 in a dose of 2 mg/kg increased plasma and erythrocyte levels of MDA and reduced glutathione, activities of glutathione-S-transferase, glutathione reductase, and gamma-glutamyl transferase in their 4-month-old progeny. Changes in the function of glutathione system and LPO intensity after cadmium intoxication during the neonatal were less pronounced than after prenatal exposure.
authors.affiliation: Department of Biochemistry and Biophysics, N. G. Chernyshevsky Saratov State University, Russia. slyuzova@mail.ru
authors.forename: O V
authors.initials: OV
authors.lastname: Slyuzova
authors.forename: E V
authors.initials: EV
authors.lastname: Stepanova
authors.forename: A D
authors.initials: AD
authors.lastname: Temraleeva
authors.forename: R A
authors.initials: RA
authors.lastname: Kireev
authors.forename: V V
authors.initials: VV
authors.lastname: Ignatov
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D005978:Glutathione / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D011247:Pregnancy; D051381:Rats; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D002104:Cadmium; D008315:Malondialdehyde; D005980:Glutathione Reductase; D005723:gamma-Glutamyltransferase; D005982:Glutathione Transferase; D005978:Glutathione