The synthesis and in vivo evaluation of 2',2'-difluoro KRN7000.
The synthesis of 2',2'-difluoro KRN7000 is described. In vivo evaluation demonstrates that this fluorinated glycolipid induces CD1d-dependent TCR activation of NKT cells, with a bias towards Th2 cytokine production.
Leung
Leo
L
School of Chemistry, University of Southampton Highfield, Southampton SO17 1BJ, UK.
Tomassi
Cyrille
C
Van Beneden
Katrien
K
Decruy
Tine
T
Trappeniers
Matthias
M
Elewaut
Dirk
D
Gao
Yifang
Y
Elliott
Tim
T
Al-Shamkhani
Aymen
A
Ottensmeier
Christian
C
Werner
Jörn M
JM
Williams
Anthony
A
Van Calenbergh
Serge
S
Linclau
Bruno
B
D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D005699:Galactosylceramides / Q000138:chemical synthesis* / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D055611:Natural Killer T-Cells; D055607:Receptors, Natural Killer Cell / Q000276:immunology
C541342:2',2'-difluoro KRN7000; D018949:Antigens, CD1; D016207:Cytokines; D005699:Galactosylceramides; D055607:Receptors, Natural Killer Cell