Arrhythmogenic threshold of the myocardium under conditions of magnesium deficiency.
We studied the arrhythmogenic threshold of the myocardium after injection of CaCl2 to magnesium-deficient rats receiving Mg2+ L-aspartate, MgCl2, their combination with vitamin B6, and reference preparations Magne B6 and MgSO4 until complete compensation of magnesium level in the plasma and erythrocytes. Magnesium-deficient diet and deionized water were used for inducing alimentary Mg2+ deficiency and modeling pathological changes in rats. After reducing Mg2+ level to 0.7 mmol/liter in the plasma and to 1.5 mmol/liter in erythrocytes, Mg L-aspartate, MgCl2, their combination with vitamin B6, as well as Mg2+ deficiency led to a decrease in the dose of CaCl2 provoking heart rhythm disturbances in 50% animals and shortening of animal life span. Administration of the test magnesium salts increased the arrhythmogenic threshold; Mg2+ salts were comparable by their efficiency with Magne B6 and were far superior to MgSO4.
Spasov
A A
AA
Institute of Pharmacology; Department of Pharmacology, Volgograd State Medical University, Russia. farm@vlpost.ru
Iezhitsa
I N
IN
Kharitonova
M V
MV
Gurova
N A
NA
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology*; D001224:Aspartic Acid / Q000737:chemistry / Q000378:metabolism; D004032:Diet; D008274:Magnesium / Q000097:blood*; D015636:Magnesium Chloride / Q000378:metabolism; D008275:Magnesium Deficiency / Q000097:blood*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D025101:Vitamin B 6 / Q000378:metabolism
D015636:Magnesium Chloride; D001224:Aspartic Acid; D025101:Vitamin B 6; D008274:Magnesium