Differential immunoreactivity of microglial and astrocytic marker protein in the hippocampus of the seizure resistant and sensitive gerbils.
In the present study, we compared differences in ionized calcium-binding adapter molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP) immunoreactivities for microglia and astrocytes, respectively, in the hippocampus of the seizure-resistant (SR) and seizure-sensitive (SS) gerbils. The density of Iba-1 immunoreactive microglia in the hippocampal CA1 region (CA1) and dentate gyrus (DG) of the SS gerbil was higher than that in the SR gerbil, and many Iba-1 immunoreactive microglia in the SS gerbil were hypertrophied in morphology. In contrast, we could not find significant difference in the density of GFAP immunoreactive astrocytes between the SR and SS gerbils. This result indicates that Iba-1 immunoreactive microglia in CA1 and DG of the SS gerbil are activated compared to those in the SR gerbil.
Lee
Choong Hyun
CH
Department of Anatomy and Neurobiology, Hallym University, South Korea.
Hwang
In Koo
IK
Lee
In Se
IS
Yoo
Ki-Yeon
KY
Choi
Jung Hoon
JH
Lee
Bong-Hee
BH
Won
Moo-Ho
MH
D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005786:Gene Expression Regulation; D005849:Gerbillinae / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism*; D017628:Microglia / Q000378:metabolism*; D012640:Seizures / Q000378:metabolism*
D015415:Biomarkers; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins