D-cycloserine potentiates the reconsolidation of cocaine-associated memories.
Conditioned cue-induced relapse to drug seeking is a major challenge to the treatment of drug addiction. It has been proposed that D-cycloserine might be useful in the prevention of relapse by reducing the conditioned reinforcing properties of drug-associated stimuli through facilitation of extinction. Here we show that intrabasolateral amygdala infusions of D-cycloserine in fact potentiate the reconsolidation of stimulus-cocaine memories to increase cue-induced relapse to drug seeking in rats with an extensive drug self-administration history. This elevation of cocaine seeking was correlated with an increase in the expression of the reconsolidation-associated gene zif268.
Lee
Jonathan L C
JL
Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, United Kingdom. j.l.c.lee@bham.ac.uk
Gardner
Richard J
RJ
Butler
Victoria J
VJ
Everitt
Barry J
BJ
D000679:Amygdala; D000818:Animals; D000963:Antimetabolites / Q000008:administration & dosage / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D019970:Cocaine-Related Disorders / Q000523:psychology*; D003216:Conditioning, Operant / Q000187:drug effects; D003463:Cues; D003523:Cycloserine / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D005108:Extinction, Psychological / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D008845:Microinjections; D051381:Rats; D012008:Recurrence
D000963:Antimetabolites; D003523:Cycloserine; D003042:Cocaine