title: Oral candidiasis in HIV+ patients under treatment with protease inhibitors.
abstract: The purpose of this work was to evaluate the influence of Protease Inhibitors (PI) on the occurrence of oral candidiasis in 111 HIV+ patients under PI therapy (Group A). The controls consisted of 56 patients that were not using PI drugs (Group B) and 26 patients that were not using any drugs for HIV therapy (Group C). The patient's cd4 cell counts were taken in account for the correlations. One hundred and ninety three patients were evaluated. The PI did not affect the prevalence of oral candidiasis (p = 0.158) or the frequency of C. albicans isolates (p = 0.133). Patients with lower cd4 cell counts showed a higher frequency of C. albicans isolates (p = 0.046) and a greater occurrence of oral candidiasis (p = 0.036).
authors.affiliation: Department of Stomatology, School of Dentistry, University of São Paulo, Brazil.
authors.forename: Andréa Lusvarghi
authors.initials: AL
authors.lastname: Witzel
authors.forename: Fernando Ricardo Xavier da
authors.initials: FR
authors.lastname: Silveira
authors.forename: Maria de Fátima Costa
authors.initials: Mde F
authors.lastname: Pires
authors.forename: Mônica Andrade
authors.initials: MA
authors.lastname: Lotufo
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000998:Antiviral Agents / Q000627:therapeutic use*; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D002176:Candida albicans / Q000187:drug effects / Q000302:isolation & purification*; D002180:Candidiasis, Oral / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D016009:Chi-Square Distribution; D005260:Female; D017320:HIV Protease Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000382:microbiology*; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D017320:HIV Protease Inhibitors