Linkage and association study of FcgammaR polymorphisms in celiac disease.
The Fcgamma receptor cluster on chromosome 1q23 contains a number of genes that may affect susceptibility to celiac disease, but previous studies have yielded contradictory results. We studied the FcgammaRIIa*A519G (rs1801274) and FcgammaRIIIa*A559C (rs396991) single nucleotide polymorphisms in celiac disease families from Hungary and Finland and in celiac disease case-control materials from Hungary and Italy. Neither the Hungarian nor the Italian case-control material or a meta-analysis of the combined case-control material showed significant single-marker or haplotype association. In addition, neither linkage nor family-based association tests showed evidence for association in the Finnish or Hungarian family material. This study thus does not support a previous publication showing FcgammaR association with celiac disease.
Sareneva
I
I
Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland.
Koskinen
L L E
LL
Korponay-Szabo
I R
IR
Kaukinen
K
K
Kurppa
K
K
Ziberna
F
F
Vatta
S
S
Not
T
T
Ventura
A
A
Adány
R
R
Pocsai
Z
Z
Széles
G
G
Mäki
M
M
Saavalainen
P
P
Einarsdottir
E
E
D016022:Case-Control Studies; D002446:Celiac Disease / Q000453:epidemiology / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D005387:Finland / Q000453:epidemiology; D005787:Gene Frequency; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D007558:Italy / Q000453:epidemiology; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*
C496124:FCGR3A protein, human; C080568:Fc gamma receptor IIA; D017452:Receptors, IgG