Regulation and functional role of eEF1A2 in pancreatic carcinoma.
Pancreatic cancer typically has an unfavourable prognosis due to late diagnosis and a lack of therapeutic options. Thus, it is important to better understand its pathological mechanism and to develop more effective treatments for the disease. Human chromosome 20q13 has long been suspected to harbour oncogenes involved in pancreatic cancer and other tumours. In this study, we found that eEF1A2, a gene located in 20q13, was significantly upregulated in pancreatic cancer. Little or no expression of eEF1A2 was detected in normal human pancreatic and chronic pancreatitis tissues, whereas increased eEF1A2 expression occurred in 83% of the pancreatic cancers we studied. Furthermore, using in vitro and in vivo model systems, we found that overexpression of eEF1A2 promoted cell growth, survival, and invasion in pancreatic cancer. Our data thus suggest that eEF1A2 might play an important role in pancreatic carcinogenesis, possibly by acting as a tumour oncogene.
Cao
Haixia
H
Department of Gastroenterology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, No. 197 Rui Jin Er Road, Shanghai 200025, China.
Zhu
Qi
Q
Huang
Jia
J
Li
Baiwen
B
Zhang
Su
S
Yao
Weiyan
W
Zhang
Yongping
Y
D000818:Animals; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology*; D002448:Cell Adhesion; D002465:Cell Movement; D049109:Cell Proliferation; D006801:Humans; D051379:Mice; D009361:Neoplasm Invasiveness; D009857:Oncogenes / Q000502:physiology*; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000473:pathology*; D020648:Peptide Elongation Factor 1 / Q000235:genetics / Q000502:physiology*; D023041:Xenograft Model Antitumor Assays
C503234:EEF1A2 protein, human; D020648:Peptide Elongation Factor 1