title: Adjuvant CCNU (lomustine) and prednisone chemotherapy for dogs with incompletely excised grade 2 mast cell tumors.
abstract: The use of adjuvant 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU; lomustine) to treat incompletely excised canine mast cell tumors (MCTs) has not been evaluated. Medical records of 12 dogs with grade 2 MCT treated with incomplete surgical excision and adjuvant CCNU and prednisone chemotherapy were reviewed. Local recurrence rate, metastasis rate, and survival time were evaluated. None of the dogs developed local recurrence or regional/ distant metastases. Two dogs developed fatal liver failure. The 1- and 2-year progression-free rates of surviving dogs were 100% and 77%, respectively. Postoperative adjuvant CCNU appears to be a useful alternative to radiation therapy for incompletely excised canine cutaneous MCTs.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, 601 Vernon L. Tharp Street, Columbus, Ohio 43210, USA.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hosoya
authors.forename: William C
authors.initials: WC
authors.lastname: Kisseberth
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Alvarez
authors.forename: Ana
authors.initials: A
authors.lastname: Lara-Garcia
authors.forename: Gillian
authors.initials: G
authors.lastname: Beamer
authors.forename: Paul C
authors.initials: PC
authors.lastname: Stromberg
authors.forename: C Guillermo
authors.initials: CG
authors.lastname: Couto
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D017093:Liver Failure / Q000209:etiology / Q000662:veterinary; D008130:Lomustine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D012515:Mast-Cell Sarcoma / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D011241:Prednisone / Q000627:therapeutic use*; D012189:Retrospective Studies; D016019:Survival Analysis
chemical_list: D018906:Antineoplastic Agents, Alkylating; D018931:Antineoplastic Agents, Hormonal; D008130:Lomustine; D011241:Prednisone