title: Congenital stage 1 neuroblastoma evolved into stage 4s.
abstract: A newborn with a prenatally detected adrenal mass underwent complete resection of a stage 1 favorable histology neuroblastoma (NB) without MYC-N amplification. Two months later, the infant presented with a local recurrence and multiple hepatic metastases. Close follow-up without therapy was adopted for stage 4s NB. Enlarging tumor lesions were seen until the child was 8 months old, followed by later decrease in size. At 36 months of follow-up, the child is alive and disease-free. We describe this case of NB and its abnormally short evolution from stage 1 to stage 4s, despite initial surgery. Its spontaneous regression may help us understand the natural history of congenital NB.
authors.affiliation: Departments of Pediatrics, University Sapienza, Rome, Italy. Amaliasc@tiscali.it
authors.forename: Amalia
authors.initials: A
authors.lastname: Schiavetti
authors.forename: Micaela
authors.initials: M
authors.lastname: Foco
authors.forename: Annapaola
authors.initials: A
authors.lastname: Ingrosso
authors.forename: Damiano
authors.initials: D
authors.lastname: Chiriacò
authors.forename: Laura
authors.initials: L
authors.lastname: Ballesio
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000151:congenital / Q000473:pathology* / Q000601:surgery; D005260:Female; D016259:Genes, myc; D006801:Humans; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D008297:Male; D009365:Neoplasm Regression, Spontaneous; D009367:Neoplasm Staging; D018365:Neoplasm, Residual / Q000517:prevention & control; D009447:Neuroblastoma / Q000151:congenital / Q000473:pathology* / Q000601:surgery; D011247:Pregnancy; D016216:Ultrasonography, Prenatal