title: Polymerizable semi-fluorinated gemini surfactants designed for antimicrobial materials.
abstract: Introduction of biocide monomers during the process of polymerization is one of promising approaches in the development of new permanent non leaching biocide materials. In this perspective, new polymerizable semi-fluorinated gemini surfactants, with quaternary ammonium groups as polar heads and an acrylic function as the polymerizable moiety, were synthesized and tested to evaluate their surface active properties alongside with their antibacterial and antifungal properties. Four microbial strains, known for their implication in nosocomial infections, were used to perform the study: Pseudomonas aeruginosa, Staphylococcus aureus, Candida albicans and Aspergillus niger. The biocide efficacy measured by bacterial and fungal growth inhibition expressed as MIC (minimal inhibitory concentration) and MLC (minimal lethal concentration) values was discussed as a function of molecular parameters. As compared to homologue compounds without acrylic part, this study shows that even the introduction of a polymerizable moiety allows to keep remarkable both surfactant and bacteriostatic activities, and allows us to envisage the use of these surfactant monomers to build up advanced biocide materials. Moreover, semi-fluorinated gemini surfactant monomers with an amide connector came out as broad spectrum biocides (against Gram positive and negative bacteria and fungi).
authors.affiliation: Université de Nice-Sophia Antipolis, Laboratoire de Chimie des Matériaux Organiques et Métalliques (CMOM), Institut de Chimie de Nice FR 3037 CNRS, Parc Valrose, 06108 Nice Cedex 2, France. laurent.caillier@unice.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Caillier
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Taffin de Givenchy
authors.forename: Richard
authors.initials: R
authors.lastname: Levy
authors.forename: Yves
authors.initials: Y
authors.lastname: Vandenberghe
authors.forename: Serge
authors.initials: S
authors.lastname: Geribaldi
authors.forename: Frederic
authors.initials: F
authors.lastname: Guittard
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001234:Aspergillus niger / Q000254:growth & development; D001419:Bacteria / Q000254:growth & development; D002176:Candida albicans / Q000254:growth & development; D003428:Cross Infection / Q000517:prevention & control*; D006801:Humans; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D006845:Hydrocarbons, Fluorinated; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents