[A chromatographic and surface-activity analysis of the fractions of Rokopols, block copolymers of propylene oxide and ethylene oxide separated from the technical product].
A metod of refininig technical Rokopols, products of copolymerization of ethylene oxide and propylene oxide of 30p160, 30p27 and 30p10 type was developed. The course of the relation between R(f)(R(m)) and the number of oxyethylene segments n(TE) in the molecule of the homological series ofpolyethyleneglycols (PEG) was used to examine the content of n(TE) in the refined fractions of Rokopols. For the aqueous solutions of Rokopols weight-average molecular mass M(w) was calculated and the surface tension coefficient gamma25 was determined on the basis of the stalgmometric method. The value of the critical micellar concentration (cmc) and the thermodynamic potential for micelle formation (DeltaG(m)(0)), which facilitates the assessment of the solubilizing abilities of the investigated class of copolymers, were estimated.
Zgoda
Marian Mikołaj
MM
Zakład technologii Postaci Leku, Katedra Farmacji Stosowanej Uniwersytetu Medycznego w Łodzi. mmzgoda@pharm.am.lodz.pl
Nachajski
Michał Jakub
MJ
D002845:Chromatography; D004852:Epoxy Compounds / Q000737:chemistry*; D005027:Ethylene Oxide / Q000737:chemistry*; D008823:Micelles; D008970:Molecular Weight; D011108:Polymers / Q000737:chemistry; D012996:Solutions / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D013816:Thermodynamics
D004852:Epoxy Compounds; D008823:Micelles; D011108:Polymers; D012996:Solutions; D013501:Surface-Active Agents; D005027:Ethylene Oxide; C009068:propylene oxide