Mechanisms of regulated unconventional protein secretion.
Most eukaryotic proteins are secreted through the conventional endoplasmic reticulum (ER)-Golgi secretory pathway. However, cytoplasmic, nuclear and signal-peptide-containing proteins have been shown to reach the cell surface by non-conventional transport pathways. The mechanisms and molecular components of unconventional protein secretion are beginning to emerge, including a role for caspase 1 and for the peripheral Golgi protein GRASP, which could function as a plasma membrane tether for membrane compartments during specific stages of development.
Nickel
Walter
W
Heidelberg University Biochemistry Center, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany. walter.nickel@bzh.uni-heidelberg.de
Rabouille
Catherine
C
D000818:Animals; D020170:Caspase 1 / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D021382:Protein Sorting Signals; D021381:Protein Transport / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D055571:Secretory Pathway / Q000502:physiology*
D021382:Protein Sorting Signals; D011506:Proteins; D020170:Caspase 1