title: The asymmetric total synthesis of (-)-securinine.
abstract: The alkaloid (-)-securinine was synthesized in 18 steps and 16% overall yield from trans-4-hydroxy-l-proline.
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Avenue, Windsor, Ontario, CanadaN9B 3P4.
authors.forename: Bhartesh
authors.initials: B
authors.lastname: Dhudshia
authors.forename: Benjamin F T
authors.initials: BF
authors.lastname: Cooper
authors.forename: Charles L B
authors.initials: CL
authors.lastname: Macdonald
authors.forename: Avinash N
authors.initials: AN
authors.lastname: Thadani
mesh_terms: D001381:Azepines / Q000138:chemical synthesis*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones / Q000138:chemical synthesis*; D010880:Piperidines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D001381:Azepines; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D010880:Piperidines; C000785:securinine