Radioimmunotherapy is effective against high-inoculum Cryptococcus neoformans infection in mice and does not select for radiation-resistant cryptococcal cells.
We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.
Bryan
Ruth A
RA
Departments of Nuclear Medicine,Albert Einstein College of Medicine, Bronx, New York 10461, USA. edadacho@aecom.yu.edu
Jiang
Zewei
Z
Huang
Xianchun
X
Morgenstern
Alfred
A
Bruchertseifer
Frank
F
Sellers
Rani
R
Casadevall
Arturo
A
Dadachova
Ekaterina
E
D000818:Animals; D001921:Brain / Q000382:microbiology / Q000473:pathology; D003453:Cryptococcosis / Q000382:microbiology / Q000473:pathology / Q000532:radiotherapy*; D003455:Cryptococcus neoformans / Q000528:radiation effects*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D051379:Mice; D011836:Radiation Tolerance; D016499:Radioimmunotherapy