title: GenomeGraphs: integrated genomic data visualization with R.
abstract: BACKGROUND
  Biological studies involve a growing number of distinct high-throughput experiments to characterize samples of interest. There is a lack of methods to visualize these different genomic datasets in a versatile manner. In addition, genomic data analysis requires integrated visualization of experimental data along with constantly changing genomic annotation and statistical analyses.
  
  
  RESULTS
  We developed GenomeGraphs, as an add-on software package for the statistical programming environment R, to facilitate integrated visualization of genomic datasets. GenomeGraphs uses the biomaRt package to perform on-line annotation queries to Ensembl and translates these to gene/transcript structures in viewports of the grid graphics package. This allows genomic annotation to be plotted together with experimental data. GenomeGraphs can also be used to plot custom annotation tracks in combination with different experimental data types together in one plot using the same genomic coordinate system.
  
  
  CONCLUSIONS
  GenomeGraphs is a flexible and extensible software package which can be used to visualize a multitude of genomic datasets within the statistical programming environment R.
authors.affiliation: Life Sciences Department, Lawrence Berkeley National Laboratory, 1 Cyclotron Rd, Berkeley, CA 94720, USA. steffen@stat.berkeley.edu
authors.forename: Steffen
authors.initials: S
authors.lastname: Durinck
authors.forename: James
authors.initials: J
authors.lastname: Bullard
authors.forename: Paul T
authors.initials: PT
authors.lastname: Spellman
authors.forename: Sandrine
authors.initials: S
authors.lastname: Dudoit
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D003196:Computer Graphics; D003627:Data Interpretation, Statistical; D005091:Exons; D016678:Genome; D023281:Genomics / Q000379:methods; D006801:Humans; D015233:Models, Statistical; D011381:Programming Languages; D020033:Protein Isoforms; D012984:Software; D014158:Transcription, Genetic; D014584:User-Computer Interface
chemical_list: D020033:Protein Isoforms