[Fibrillary glomerulonephritis].
Fibrillary glomerulonephritis is a rare disease of unknown etiology and pathogenesis. In two thirds of cases, it is clinically manifested by the nephrotic syndrome resistant to cytostatic and corticosteroid therapy. Fibrillary glomerulonephritis is diagnosed by electronic microscopy and characterized by the presence of chaotically located fibrils with an average diameter of 18-22 nm in the deposits of immune complexes. Light optical and immunohistochemical studies are of no crucial importance in this disease. Further investigations may answer a number of questions as to the formation of immune complex deposits and ways of their elimination.
Varshavskiĭ
V A
VA
Golitsyna
E P
EP
D000293:Adolescent; D000936:Antigen-Antibody Complex / Q000032:analysis / Q000276:immunology; D049109:Cell Proliferation; D005260:Female; D005920:Glomerular Mesangium / Q000276:immunology / Q000648:ultrastructure; D015433:Glomerulonephritis, Membranous / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000276:immunology* / Q000648:ultrastructure*; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D055815:Young Adult
D000936:Antigen-Antibody Complex