title: Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells.
abstract: Gold nanoparticles functionalized with water-soluble zwitterionic ligands form kinetically stable complexes with hydrophobic drugs and dyes. These drugs and dyes are efficiently released into cells, as demonstrated through fluorescence microscopy and cytotoxicity assays. Significantly, there is little or no cellular uptake of particle, making these low toxicity particles promising for delivery applications.
authors.affiliation: Department of Chemistry, University of Massachusetts at Amherst, Amherst, Massachusetts 01003, USA.
authors.forename: Chae Kyu
authors.initials: CK
authors.lastname: Kim
authors.forename: Partha
authors.initials: P
authors.lastname: Ghosh
authors.forename: Chiara
authors.initials: C
authors.lastname: Pagliuca
authors.forename: Zheng-Jiang
authors.initials: ZJ
authors.lastname: Zhu
authors.forename: Stefano
authors.initials: S
authors.lastname: Menichetti
authors.forename: Vincent M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology; D004364:Pharmaceutical Preparations / Q000737:chemistry*
chemical_list: D004364:Pharmaceutical Preparations; D006046:Gold