Isolation of a human intestinal bacterium capable of daidzein and genistein conversion.
A rod-shaped gram-positive anaerobic bacterium, strain HE8, was isolated from human feces. The isolate was able to convert the isoflavones daidzein and genistein to equol and 5-hydroxy-equol, respectively. Based on phenotypic and phylogenetic analyses, strain HE8 is described as a new species, Slackia isoflavoniconvertens.
Matthies
Anastasia
A
Department of Gastrointestinal Microbiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.
Blaut
Michael
M
Braune
Annett
A
D039903:Actinobacteria / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D000332:Aerobiosis; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D060754:Equol; D005243:Feces / Q000382:microbiology; D041981:Gastrointestinal Tract / Q000382:microbiology*; D020459:Genes, rRNA; D019833:Genistein / Q000378:metabolism*; D006801:Humans; D007529:Isoflavones / Q000378:metabolism*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid
C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D007529:Isoflavones; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; D060754:Equol; C004742:daidzein; D019833:Genistein