Total synthesis of FR901483.
The architecturally sophisticated skeleton of the immunosuppressive alkaloid FR901483 was assembled via a process relying on the reaction of an in situ generated imine with a suitably disposed donor-acceptor cyclopropane. A short sequence of functional group transformations provided the natural product in an efficient manner.
Carson
Cheryl A
CA
Department of Chemistry, The University of Western Ontario, London, Ontario, Canada N6A 5B7.
Kerr
Michael A
MA
D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D006999:Hypocreales / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D000470:Alkaloids; C098358:FR 901483; D007166:Immunosuppressive Agents; D009943:Organophosphorus Compounds