title: [Mitochondrial signaling: retrograde regulation in yeast Saccharomyces cerevisiae].
abstract: The review considers the current views of the yeast signaling system that connects mitochondria with the nucleus and is known as retrograde regulation. The adaptive character of this signaling system is emphasized. The system is activated upon damage to mitochondrial functions (e.g., by stress or mutations) and is aimed at adapting the cell to the changed functional state of the organelles. The retrograde signaling system is controlled by positive (Rtglp, Rtg2p, Rtg3p, and Grr1p) and negative (Mks1p, Lst8p, Bmh1p, and Bmh2p) regulatory factors. The possibility of several retrograde pathways existing in mitochondria is discussed in brief. Data on some functions of retrograde regulation are described.
authors.forename: N P
authors.initials: NP
authors.lastname: Iurina
authors.forename: M S
authors.initials: MS
authors.lastname: Odintsova
mesh_terms: D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D029701:Saccharomyces cerevisiae Proteins