Novel benzil and isoflavone derivatives from Millettia dielsiana.
The analysis of vine stem extract from MILLETTIA DIELSIANA Harms yielded a novel benzil ( 1) and five new prenylated isoflavones ( 2 - 6) together with three known isoflavones ( 7 - 10) and one known flavone ( 11), and their structures were elucidated on the basis of chemical and spectral analysis. The absolute configuration of the 3'',4''-diols in 6 was determined by observing the CD induced after addition of dimolybdenum tetraacetate in DMSO solution (Snatzke's method). Some isolates were tested for their anti-inflammatory and antithrombase activities and cytotoxicities. Compound 2, barbigerone, and genistein showed significant anti-inflammatory activity, with inhibitory ratios 59.1 %, 59.5 %, and 58.5 %, respectively, at 10 muM, while compound 4 exhibited moderate cytotoxicity.
Gong
Ting
T
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education and Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China.
Wang
Dong-Xiao
DX
Chen
Ruo-Yun
RY
Liu
Ping
P
Yu
De-Quan
DQ
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005343:Fibrinolytic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047309:Flavones; D005419:Flavonoids; D005966:Glucuronidase / Q000037:antagonists & inhibitors; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D033641:Millettia / Q000737:chemistry*; D015394:Molecular Structure; D010658:Phenylglyoxal / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems; D051381:Rats; D013917:Thrombin / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D003603:Cytotoxins; D005343:Fibrinolytic Agents; D047309:Flavones; D005419:Flavonoids; D007529:Isoflavones; D010936:Plant Extracts; D005966:Glucuronidase; D013917:Thrombin; D010658:Phenylglyoxal; C043562:flavone; C006697:benzil