title: Solitary fibrous tumour of the kidney with sarcomatous overgrowth. Case report and review of the literature.
abstract: Solitary fibrous tumour (SFT) rarely occurs in the kidney, with only one case exhibiting malignant behaviour. We report the case of a typical SFT of the kidney with sarcomatous overgrowth in a 34-year-old woman. This malignant component, grossly apparent as a nodular area arising in the context of the main tumour mass, consisted of CD34+ mitotically active atypical plump spindle- to epithelioid-shaped cells, including pleomorphic multinucleated giant cells. A novel immunohistochemical finding was diffuse and strong S-100 protein expression by sarcomatous cells. This should be kept in mind by pathologists to avoid confusion with other S-100 protein-positive malignant neoplasms.
authors.affiliation: Dipartimento G.F. Ingrassia, Policlinico Universitario G. Rodolico, Anatomia Patologica, Università di Catania, Catania, Italy. g.magro@unict.it
authors.forename: Gaetano
authors.initials: G
authors.lastname: Magro
authors.forename: Carmela
authors.initials: C
authors.lastname: Emmanuele
authors.forename: Maria
authors.initials: M
authors.lastname: Lopes
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Vallone
authors.forename: Paolo
authors.initials: P
authors.lastname: Greco
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D009418:S100 Proteins / Q000378:metabolism; D012509:Sarcoma / Q000378:metabolism / Q000473:pathology*; D054364:Solitary Fibrous Tumors / Q000473:pathology*
chemical_list: D009418:S100 Proteins