Multicomponent synthesis of alpha-branched amides.
Alpha-branched amides are prepared by multicomponent reactions in which nitriles undergo hydrozirconation to form metalloimines that react with acyl chlorides. The resulting acylimines react with a variety of pi-nucleophiles in the presence of Lewis acids to form the desired amides.
DeBenedetto
Mikkel V
MV
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
Green
Michael E
ME
Wan
Shuangyi
S
Park
Jung-Hyun
JH
Floreancig
Paul E
PE
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry
D000577:Amides; D009570:Nitriles; D015040:Zirconium