Discovery of herpes B virus-encoded microRNAs.
Herpes B virus (BV) naturally infects macaque monkeys and is a close relative of herpes simplex virus. BV can zoonotically infect humans to cause a rapidly ascending encephalitis with approximately 80% mortality. Therefore, BV is a serious danger to those who come into contact with these monkeys or their tissues and cells. MicroRNAs are regulators of gene expression, and there have been reports of virus-encoded microRNAs. We hypothesize that BV-encoded microRNAs are important for the regulation of viral and cellular genes. Herein, we report the discovery of three herpes B virus-encoded microRNAs.
Besecker
Michael I
MI
Department of Virology and Immunology, Southwest Foundation for Biomedical Research, San Antonio, Texas 78227, USA.
Harden
Mallory E
ME
Li
Guanglin
G
Wang
Xiu-Jie
XJ
Griffiths
Anthony
A
D000818:Animals; D015152:Blotting, Northern; D002522:Chlorocebus aethiops; D015967:Gene Expression Regulation, Viral; D006568:Herpesvirus 1, Cercopithecine / Q000235:genetics / Q000502:physiology*; D035683:MicroRNAs / Q000096:biosynthesis* / Q000235:genetics; D012367:RNA, Viral / Q000096:biosynthesis* / Q000235:genetics; D014709:Vero Cells
D035683:MicroRNAs; D012367:RNA, Viral