Study of bipathic effect of haloperidol.
Parallel treatment with haloperidol and ultralow-dose haloperidol significantly increased the psychotropic neuroleptic effect of traditional doses of the drug under conditions of preliminary of simultaneous administration, which attests to a bipathic effect of this preparation. Combination of ultralow and therapeutic doses of haloperidol significantly reduced its cataleptogenic side effect.
Voronina
T A
TA
Materia Medica Holding, Moscow, Russia. nauka@materiamedica.ru
Belopolskaya
M V
MV
Kheyfets
I A
IA
Dugina
J L
JL
Sergeeva
S A
SA
Epstein
O I
OI
D000818:Animals; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001058:Apomorphine / Q000008:administration & dosage; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D018491:Dopamine Agonists / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018727:Muscarinic Antagonists / Q000008:administration & dosage; D013239:Stereotyped Behavior / Q000187:drug effects; D014282:Trihexyphenidyl / Q000008:administration & dosage
D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D018727:Muscarinic Antagonists; D014282:Trihexyphenidyl; D006220:Haloperidol; D001058:Apomorphine