Elevated pretransplantation soluble CD30 is associated with decreased early allograft function after human lung transplantation.
Early allograft function after lung transplantation is variable. Clinical criteria have limited predictive value for early graft function. Recipient immunologic state before LTx may affect early lung function. We investigated the association between pretransplantation soluble CD30 (sCD30), a marker of Th2-type T-cell activation, and early clinical parameters of allograft function. Between September 2002 and January 2007, a total of 80 transplantations were performed at Johns Hopkins Hospital. Of the patients, 43 had a pretransplantation sCD30 level determined. Pre- and postoperative patient variables were collected, and patients were stratified into two groups: sCD30 <20 (low sCD30) and >20 (high sCD30). High sCD30 (n = 26) and low sCD30 (n = 17) groups were similar in age, gender, and ischemia time. In the high sCD30 group, a higher percentage of patients had pulmonary fibrosis and a lower percentage had emphysema. Oxygenation at 48 hours was significantly worse in the high sCD30 group as compared with the low sCD30 (p = 0.003). Moreover, prolonged intubation and 90-day mortality were greater in the high sCD30 group. This represents the first report of the use of sCD30 as a marker for early allograft function in human lung transplanation. Increased pretransplantation recipient sCD30 appears to be associated with decreased early post-transplantation gas exchange, prolonged intubation, and early mortality.
Shah
Ashish S
AS
ashah29@jhmi.edu
Leffell
M Sue
MS
Lucas
Donna
D
Zachary
Andrea A
AA
D000328:Adult; D015331:Cohort Studies; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis* / Q000276:immunology; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D017730:Ki-1 Antigen / Q000276:immunology*; D016040:Lung Transplantation / Q000276:immunology*; D008875:Middle Aged; D014184:Transplantation, Homologous / Q000276:immunology*; D055815:Young Adult
D017730:Ki-1 Antigen