title: Radiofrequency catheter ablation of atrial fibrillation in older patients: outcomes and complications.
abstract: BACKGROUND
  Catheter ablation (CA) of atrial fibrillation (AF) has become a treatment option for younger patients with drug refractory AF. It is not known whether pulmonary veins (PV) have an important mechanistic role in elderly patients with AF or whether CA is an effective treatment for the elderly.
  
  
  METHODS
  We evaluated 240 consecutive patients that were referred to the electrophysiology laboratory for CA for AF using a PV antral isolation approach. Linear ablations were not routinely performed. Clinical outcomes and healthcare resource utilization was evaluated during the 12 months after CA in patients <65 years old (Group 1; 91 patients), 65-75 years old (Group II; 88 patients), and >75 years old (Group III; 61 patients).
  
  
  RESULTS
  Older patients were more likely to have persistent atrial fibrillation (I: 24%, II: 34%, III: 66%). Major complication rates (I: 1%; II: 1%; III: 0%; p=ns) and minor complication rates (I: 4%; II: 5%; III: 5%; p=ns) were similar for all three groups. At 12 month follow-up younger patients were more likely to be in sinus rhythm without prolonged episodes of atrial fibrillation without antiarrhythmic drug therapy (AARx) (I: 94%, II: 84%, III: 61%). However in Group III, effective treatment (AF <1 h/mo +/- AARx) was achieved in 82% of patients. After radiofrequency catheter ablation, hospitalizations, emergency room and nonroutine clinic visits decreased significantly for all three groups during the 12 months after RFA (I: pre 22; post: 3; Group II: pre 26; post 4; III: pre 20; post 2).
  
  
  CONCLUSIONS
  CA can be effective for treating AF in selected older patients as stand-alone therapy or as hybrid therapy with AARx. PVs appear to be an important arrhythmogenic structure regardless of age. CA is associated with decreased healthcare resource utilization in all age groups.
authors.affiliation: Electrophysiology and Pacing Service, Division of Cardiovascular Disease, Department of Medicine, Mayo Clinic, 4500 San Pablo Ave, Jacksonville, FL 32224, USA. Kusumoto.fred@mayo.edu
authors.forename: Fred
authors.initials: F
authors.lastname: Kusumoto
authors.forename: Karin
authors.initials: K
authors.lastname: Prussak
authors.forename: Melissa
authors.initials: M
authors.lastname: Wiesinger
authors.forename: Tammy
authors.initials: T
authors.lastname: Pullen
authors.forename: Cynthia
authors.initials: C
authors.lastname: Lynady
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000401:mortality* / Q000601:surgery*; D017115:Catheter Ablation / Q000401:mortality* / Q000706:statistics & numerical data*; D005260:Female; D005431:Florida / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D018570:Risk Assessment / Q000379:methods; D012307:Risk Factors; D017678:Sex Distribution; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome