title: Cerebral leukoaraiosis in patients with stroke or TIA: clinical correlates and 1-year outcome.
abstract: OBJECTIVE
  Cerebral leukoaraiosis is frequently observed in patients with acute stroke, but its clinical consequences on functional recovery remain incompletely defined. We evaluated the clinical correlates of leukoaraiosis, and its association with stroke-outcome in a cohort of consecutively hospitalized patients.
  
  
  METHODS
  One-thousand twenty-four consecutive patients with acute stroke or transient ischemic attack (TIA) undergoing brain CT were included in this single-center study. Patients were systematically evaluated at hospitalization and followed-up for 1 year. Mortality, functional outcome, quality of life (QoL), psychological distress, community integration, and patient perception of recovery were evaluated by leukoaraiosis severity. Adjusted ORs (95%CI) were calculated.
  
  
  RESULTS
  Moderate/severe leukoaraiosis was diagnosed in 177 patients (17.3%) and mild leukoaraiosis in 362 patients (35.3%). After 1 year, adjusted ORs for moderate/severe leukoaraiosis compared with no leukoaraiosis were 2.0 (95%CI 1.1-4.0) for Barthel Index <or=75; 1.9 (95%CI 0.9-4.0) for help needed in ADL; 2.5 (95%CI 1.0-6.3) for not feeling totally recovered; 2.0 (95%CI 1.1-4.1) for low QoL; 1.9 (95%CI 1.0-3.5) for psychological distress, and 1.6 (95%CI 0.9-2.9) for reduced community integration.
  
  
  CONCLUSIONS
  In a large cohort of consecutive patients hospitalized for stroke or TIA, leukoaraiosis predicted poor functional recovery, worse QoL and community integration, and higher psychological distress during the first year following stroke onset.
authors.affiliation: From the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Koton
authors.forename: Y
authors.initials: Y
authors.lastname: Schwammenthal
authors.forename: O
authors.initials: O
authors.lastname: Merzeliak
authors.forename: T
authors.initials: T
authors.lastname: Philips
authors.forename: R
authors.initials: R
authors.lastname: Tsabari
authors.forename: D
authors.initials: D
authors.lastname: Orion
authors.forename: R
authors.initials: R
authors.lastname: Dichtiar
authors.forename: D
authors.initials: D
authors.lastname: Tanne
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000150:complications* / Q000473:pathology; D049292:Leukoaraiosis / Q000150:complications* / Q000473:pathology; D008297:Male; D020127:Recovery of Function; D012307:Risk Factors; D020521:Stroke / Q000150:complications* / Q000473:pathology; D014057:Tomography, X-Ray Computed