Desensitization in interferon-beta1a allergy: a case report.
We report a 41-year-old patient with multiple sclerosis (MS) who was successfully desensitized after she developed non-injection-site urticaria and angioedema due to interferon (IFN)-beta1a. Although a few cases of urticaria and anaphylaxis have been reported in the literature, to our knowledge this is the first report of a successful desensitization with IFN-beta1a. Desensitization with IFN-beta1a allowed us to continue with the administration of interferon-beta, which is a mainstay in treatment for MS.
Fusun Kalpaklioglu
Ayse
A
Department of Allergic Diseases, Kirikkale University, Pak Sokak No. 3/100, Portakal Cicegi Sokak, Cankaya, Ankara TR-06690, Turkey. afusunk@yahoo.com
Baccioglu Kavut
Ayse
A
Erdemoglu
Ali Kemal
AK
D000328:Adult; D000799:Angioedema / Q000209:etiology / Q000628:therapy*; D003888:Desensitization, Immunologic; D004342:Drug Hypersensitivity / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000008:administration & dosage* / Q000009:adverse effects*; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy; D014581:Urticaria / Q000209:etiology / Q000628:therapy*
D016899:Interferon-beta; D000068556:Interferon beta-1a