title: Primary and locally recurrent retroperitoneal soft-tissue sarcoma: local control and survival.
abstract: OBJECTIVE
  To evaluate local control for long-term prognosis in retroperitoneal soft-tissue sarcoma (primary tumors (PT) and local recurrence (LR)).
  
  
  METHODS
  A total of 110 patients underwent surgery between 1988 and 2002. Prospectively gathered clinicopathological data were analyzed. Kaplan-Meier estimations and Cox regression analyses were performed.
  
  
  RESULTS
  Resectability was 90%, being comparable for PT (n=71) and LR (n=39). Morbidity, mortality, blood loss, and operation time did not differ for PT or LR (24% vs. 31%, p=0.41; 7.0% vs. 5.1%, p=1.0; 1000 ml vs. 1500 ml, p=0.17; 240 min vs. 255 min, p=0.13). Hospitalization was comparable in both groups (median, 12 days (PT) and 13 days (LR)). Follow-up was 89 months (median, IQR 37-112 months). Local 3- and 5-year control rates after complete resection of PT were 66% and 59% (19% and 9% for LR, p<0.001). The mean number of operations were 1.4 for PT and 2.4 for LR (p=0.0047). The 5-year survival rates after complete resection were 51% for PT and 43% for LR (p=0.39). The 5-year survival rates were 65%, 4%, and 0% for complete resection, incomplete resection, and exploration, respectively (p<0.001). Multivariate analysis showed high-grade and blood loss with a poor prognosis.
  
  
  CONCLUSIONS
  Comparable resectability rates and perioperative outcome were observed for surgery of PT and LR. Consequent reoperation leads to respectable long-term survival rates after resection of LR. The prognosis in retroperitoneal sarcomas varies significantly according to resectability, grade and blood loss.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Department of Surgery, University of Heidelberg, Heidelberg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Lehnert
authors.forename: S
authors.initials: S
authors.lastname: Cardona
authors.forename: U
authors.initials: U
authors.lastname: Hinz
authors.forename: F
authors.initials: F
authors.lastname: Willeke
authors.forename: G
authors.initials: G
authors.lastname: Mechtersheimer
authors.forename: M
authors.initials: M
authors.lastname: Treiber
authors.forename: C
authors.initials: C
authors.lastname: Herfarth
authors.forename: M W
authors.initials: MW
authors.lastname: Buechler
authors.forename: M H M
authors.initials: MH
authors.lastname: Schwarzbach
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D016016:Proportional Hazards Models; D012186:Retroperitoneal Neoplasms / Q000473:pathology / Q000601:surgery*; D012509:Sarcoma / Q000473:pathology / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000601:surgery*; D016019:Survival Analysis; D016896:Treatment Outcome