title: Preliminary evaluation of pharmacological properties of some xanthone derivatives.
abstract: A series of xanthone derivatives were synthesized and examined for electrocardiographic, antiarrhythmic, hypotensive and anticonvulsant activities as well as for alpha(1)- and beta(1)-adrenergic binding affinities. Among the investigated compounds, some of them exhibited significant antiarrhythmic and/or hypotensive activity. The data obtained via receptor binding assay are in agreement with pharmacological results and could explain antiarrhythmic and/or hypotensive activity of the newly synthesized structures.
authors.affiliation: Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, 9 Medyczna Str., 30-688 Cracow, Poland. hen.mar@interia.pl
authors.forename: Henryk
authors.initials: H
authors.lastname: Marona
authors.forename: Natalia
authors.initials: N
authors.lastname: Szkaradek
authors.forename: Anna
authors.initials: A
authors.lastname: Rapacz
authors.forename: Barbara
authors.initials: B
authors.lastname: Filipek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Dybała
authors.forename: Agata
authors.initials: A
authors.lastname: Siwek
authors.forename: Marek
authors.initials: M
authors.lastname: Cegła
authors.forename: Edward
authors.initials: E
authors.lastname: Szneler
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004562:Electrocardiography; D007700:Kinetics; D008297:Male; D051379:Mice; D051381:Rats; D017208:Rats, Wistar; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced; D044004:Xanthones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000889:Anti-Arrhythmia Agents; D000927:Anticonvulsants; D000959:Antihypertensive Agents; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2; D044004:Xanthones