Cytotoxic spirostane-type saponins from the roots of Chlorophytum borivilianum.
Four new spirostane-type saponins named borivilianosides E-H (1-4) were isolated from an ethanol extract of the roots of Chlorophytum borivilianum together with two known steroid saponins (5 and 6). The structures of 1-4 were elucidated using mainly 2D NMR spectroscopic techniques and mass spectrometry. The cytotoxicity of borivilianosides F (2), G (3), and H (4) and three known compounds was evaluated using two human colon cancer cell lines (HT-29 and HCT 116).
Acharya
Debabrata
D
Laboratoire de Pharmacognosie, Unite de Molecules d'Interet Biologique, UMIB UPRES-EA 3660, Faculte de Pharmacie, Universite de Bourgogne, 21079 Dijon Cedex, France.
Mitaine-Offer
Anne-Claire
AC
Kaushik
Nutan
N
Miyamoto
Tomofumi
T
Paululat
Thomas
T
Mirjolet
Jean-François
JF
Duchamp
Olivier
O
Lacaille-Dubois
Marie-Aleth
MA
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D000070357:Asparagaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007194:India; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013150:Spirostans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013150:Spirostans; C535146:borivilianoside F; C535145:borivilianoside G; C535144:borivilianoside H