Acute anuric renal failure with streptokinase therapy in a patient with acute venous thromboembolic disease and the review of renal side effects of streptokinase.
The benefits of thrombolytic therapy in acute myocardial infarction are now well established. However many uncertainties, such as adverse effects, are still remain in venous thromboembolic disease. We describe a unique patient who treated with streptokinase for the methylen tetrahydrofolate reductase mutation associated acute deep vein thrombosis and massive pulmonary embolism. After therapy patient developed acute anuric renal failure without an evidence of bleeding or immunologic reaction and we would like to review the renal side effects of streptokinase in patients with venous thromboembolic disease.
Onen
Zeynep
Z
Department of Chest Diseases, Faculty of Medicine, Ankara University, Ankara, Turkey. zponen@yahoo.com
Akkoca Yildiz
Oznur
O
Eriş Gülbay
Banu
B
Karabiyikoğlu
Gülseren
G
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005343:Fibrinolytic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000188:drug therapy / Q000235:genetics; D013300:Streptokinase / Q000009:adverse effects* / Q000627:therapeutic use; D020246:Venous Thrombosis / Q000188:drug therapy / Q000235:genetics
D005343:Fibrinolytic Agents; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013300:Streptokinase