Highly diastereoselective anti-aldol reactions of glycolate titanium enolates.
Diastereoselective aldol reactions of enolates of alpha-hydroxy ester with different aldehydes are metal tunable, providing either anti- or syn- products. The highest anti-selectivities were obtained with TiCl(OiPr)(3), while Ti(OiPr)(4) provides the opposite syn-products.
Gawas
Dnyaneshwar
D
Institut für Organische Chemie, Universität des Saarlandes, 66123 Saarbrücken, Germany.
Kazmaier
Uli
U
D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002614:Chelating Agents / Q000737:chemistry; D006016:Glycolates / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D014025:Titanium / Q000737:chemistry*
D000438:Alcohols; D000447:Aldehydes; D002614:Chelating Agents; D006016:Glycolates; D009942:Organometallic Compounds; C031149:glycolic acid; D014025:Titanium