18F labeled nanoparticles for in vivo PET-CT imaging.
We report the synthesis and in vivo characterization of an 18F modified trimodal nanoparticle (18F-CLIO). This particle consists of cross-linked dextran held together in core-shell formation by a superparamagnetic iron oxide core and functionalized with the radionuclide 18F in high yield via "click" chemistry. The particle can be detected with positron emission tomography, fluorescence molecular tomography, and magnetic resonance imaging. The presence of 18F dramatically lowers the detection threshold of the nanoparticles, while the facile conjugation chemistry provides a simple platform for rapid and efficient nanoparticle labeling.
Devaraj
Neal K
NK
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Simches Research Building, 185 Cambridge Street, Boston, Massachusetts 02114, USA.
Keliher
Edmund J
EJ
Thurber
Greg M
GM
Nahrendorf
Matthias
M
Weissleder
Ralph
R
D000818:Animals; D003432:Cross-Linking Reagents / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D053758:Nanoparticles / Q000737:chemistry*; D019047:Phantoms, Imaging; D011092:Polyethylene Glycols / Q000737:chemistry; D049268:Positron-Emission Tomography; D013194:Staining and Labeling; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
D003432:Cross-Linking Reagents; D003911:Dextrans; D005290:Ferric Compounds; D005462:Fluorine Radioisotopes; C000499:ferric oxide; D011092:Polyethylene Glycols