title: [New development in bisphosphonate treatment. Review of effect on bone metabolism by minodronic acid in primary osteoporosis].
abstract: Minodronic acid hydrate is a novel bisphosphonate with stronger anti-resorptive effects, compared to the other existing bisphosphonates. We performed additional analyses of phase III clinical trial and compared the effect of minodronic acid hydrate on bone turnover markers with those of alendronate in primary osteoporosis. The results showed that minodronic acid hydrate suppressed bone turnover early after treatment, and it also was effective in the treatment of patients with prevalent vertebral fracture, which is a high risk for subsequent fracture.
authors.affiliation: Kawasaki Medical School, Department of Nuclear Medicine, Japan.
authors.forename: Masao
authors.initials: M
authors.lastname: Fukunaga
mesh_terms: D019386:Alendronate / Q000494:pharmacology / Q000627:therapeutic use; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000652:urine; D050071:Bone Density Conservation Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001842:Bone and Bones / Q000378:metabolism*; D017326:Clinical Trials, Phase III as Topic; D024042:Collagen Type I / Q000652:urine; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use*; D005598:Fractures, Spontaneous / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D010024:Osteoporosis / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism*; D010455:Peptides / Q000652:urine
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D050071:Bone Density Conservation Agents; D024042:Collagen Type I; D004164:Diphosphonates; D007093:Imidazoles; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; C087958:YM 529; C036020:deoxypyridinoline; D019386:Alendronate