Helicobacter pylori, zinc and iron in oxidative stress-induced injury of gastric mucosa.
A number of study have suggested a relationship between Helicobacter pylori infection and oxidative stress in the gastric epithelium. The oxidant- induced changes in zinc, iron, and vitamin C increase susceptibility to oxidative injury. Understanding of pathophysiologic mechanisms may provide new therapeutic strategies in treatment of oxidative injury of mucosa.
Dovhanj
J
J
Department of Clinical and Laboratory Diagnostic, School of Medicine, University of Osijek, Osijek, Croatia. jdovhanj@yahoo.com
Kljaić
K
K
Dodig-Curković
K
K
Curković
M
M
Volarević
M
M
Marjanović
K
K
D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D016481:Helicobacter Infections / Q000209:etiology*; D016480:Helicobacter pylori; D006801:Humans; D007501:Iron / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology*; D015032:Zinc / Q000378:metabolism* / Q000494:pharmacology
D000975:Antioxidants; D007501:Iron; D015032:Zinc; D001205:Ascorbic Acid