title: Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.
abstract: We analyzed genome-wide association data from 1,380 Europeans with early-onset and morbid adult obesity and 1,416 age-matched normal-weight controls. Thirty-eight markers showing strong association were further evaluated in 14,186 European subjects. In addition to FTO and MC4R, we detected significant association of obesity with three new risk loci in NPC1 (endosomal/lysosomal Niemann-Pick C1 gene, P = 2.9 x 10(-7)), near MAF (encoding the transcription factor c-MAF, P = 3.8 x 10(-13)) and near PTER (phosphotriesterase-related gene, P = 2.1 x 10(-7)).
authors.affiliation: CNRS 8090-Institute of Biology, Pasteur Institute, 59000 Lille, France.
authors.forename: David
authors.initials: D
authors.lastname: Meyre
authors.forename: Jérôme
authors.initials: J
authors.lastname: Delplanque
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Chèvre
authors.forename: Cécile
authors.initials: C
authors.lastname: Lecoeur
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lobbens
authors.forename: Sophie
authors.initials: S
authors.lastname: Gallina
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Durand
authors.forename: Vincent
authors.initials: V
authors.lastname: Vatin
authors.forename: Franck
authors.initials: F
authors.lastname: Degraeve
authors.forename: Christine
authors.initials: C
authors.lastname: Proença
authors.forename: Stefan
authors.initials: S
authors.lastname: Gaget
authors.forename: Antje
authors.initials: A
authors.lastname: Körner
authors.forename: Peter
authors.initials: P
authors.lastname: Kovacs
authors.forename: Wieland
authors.initials: W
authors.lastname: Kiess
authors.forename: Jean
authors.initials: J
authors.lastname: Tichet
authors.forename: Michel
authors.initials: M
authors.lastname: Marre
authors.forename: Anna-Liisa
authors.initials: AL
authors.lastname: Hartikainen
authors.forename: Fritz
authors.initials: F
authors.lastname: Horber
authors.forename: Natascha
authors.initials: N
authors.lastname: Potoczna
authors.forename: Serge
authors.initials: S
authors.lastname: Hercberg
authors.forename: Claire
authors.initials: C
authors.lastname: Levy-Marchal
authors.forename: François
authors.initials: F
authors.lastname: Pattou
authors.forename: Barbara
authors.initials: B
authors.lastname: Heude
authors.forename: Maithé
authors.initials: M
authors.lastname: Tauber
authors.forename: Mark I
authors.initials: MI
authors.lastname: McCarthy
authors.forename: Alexandra I F
authors.initials: AI
authors.lastname: Blakemore
authors.forename: Alexandre
authors.initials: A
authors.lastname: Montpetit
authors.forename: Constantin
authors.initials: C
authors.lastname: Polychronakos
authors.forename: Jacques
authors.initials: J
authors.lastname: Weill
authors.forename: Lachlan J M
authors.initials: LJ
authors.lastname: Coin
authors.forename: Julian
authors.initials: J
authors.lastname: Asher
authors.forename: Paul
authors.initials: P
authors.lastname: Elliott
authors.forename: Marjo-Riitta
authors.initials: MR
authors.lastname: Järvelin
authors.forename: Sophie
authors.initials: S
authors.lastname: Visvikis-Siest
authors.forename: Beverley
authors.initials: B
authors.lastname: Balkau
authors.forename: Rob
authors.initials: R
authors.lastname: Sladek
authors.forename: David
authors.initials: D
authors.lastname: Balding
authors.forename: Andrew
authors.initials: A
authors.lastname: Walley
authors.forename: Christian
authors.initials: C
authors.lastname: Dina
authors.forename: Philippe
authors.initials: P
authors.lastname: Froguel
mesh_terms: D000328:Adult; D017668:Age of Onset; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D002352:Carrier Proteins / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D005060:Europe / Q000453:epidemiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000235:genetics; D000077296:Niemann-Pick C1 Protein; D009767:Obesity, Morbid / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011153:Population; D011506:Proteins / Q000235:genetics; D051257:Proto-Oncogene Proteins c-maf / Q000235:genetics; D040641:Quantitative Trait Loci; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics; D012307:Risk Factors
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C495607:MAF protein, human; C470072:MC4R protein, human; D008562:Membrane Glycoproteins; C106881:NPC1 protein, human; D000077296:Niemann-Pick C1 Protein; C484578:PTER protein, human; D011506:Proteins; D051257:Proto-Oncogene Proteins c-maf; D044105:Receptor, Melanocortin, Type 4; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human