[Antianemic effect of reamberin in rats with acute alloxan-induced diabetes].
The influence of reamberin on hematological indices in the acute period of alloxan-induced diabetes has been studied. It is established that anemia develops within 72 hours after alloxan injection at a diabetogenic dose in rats, which is related to bone marrow erythropoiesis suppression and is accompanied by inflammatory leukocytosis. Single administration of reamberin in a dose equivalent to the human therapeutic dose produces correction of the leukocyte content in the blood, normalizes the bone marrow erythropoiesis, and prevents anemia development in rats with alloxan-induced diabetes. The antianemic action of reamberin is not related to its influence on carbohydrate metabolism in experimental diabetes mellitus.
Volchegorskiĭ
I A
IA
Tishevskaia
N V
NV
Dement'eva
E V
EV
D000496:Alloxan; D000740:Anemia / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D004920:Erythropoiesis / Q000187:drug effects*; D005260:Female; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats
D008536:Meglumine; D000496:Alloxan