title: Laminar and compartmental regulation of dendritic growth in mature cortex.
abstract: Can dendrites grow in mature cortex? We used chronic in vivo imaging to follow pyramidal neurons before and after cortical deletion of the Pten tumor suppressor gene in mature mice. We found that Pten/mTOR signaling uniquely regulates the growth of layer 2/3 apical dendrites; no effects of gene deletion were observed on basal dendrites of these pyramidal neurons or along layer 5 apical dendrites.
authors.affiliation: Department of Neurobiology, David Geffen School of Medicine, University of California Los Angeles, 635 Charles Young Drive, South, Los Angeles, California 90095-1761, USA.
authors.forename: David K
authors.initials: DK
authors.lastname: Chow
authors.forename: Matthias
authors.initials: M
authors.lastname: Groszer
authors.forename: Mochtar
authors.initials: M
authors.lastname: Pribadi
authors.forename: Michal
authors.initials: M
authors.lastname: Machniki
authors.forename: S Thomas
authors.initials: ST
authors.lastname: Carmichael
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Trachtenberg
mesh_terms: D000367:Age Factors; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D002352:Carrier Proteins / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology* / Q000254:growth & development / Q000502:physiology; D003712:Dendrites / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051379:Mice; D051059:PTEN Phosphohydrolase / Q000235:genetics* / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D017966:Pyramidal Cells / Q000502:physiology* / Q000648:ultrastructure; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D020123:Sirolimus / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases
chemical_list: D000903:Antibiotics, Antineoplastic; D002352:Carrier Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor); C546842:MTOR protein, human; C546843:mTOR protein, mouse; D058570:TOR Serine-Threonine Kinases; D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse; D020123:Sirolimus