title: Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients.
abstract: OBJECTIVE
  It has been reported that elevated PRL-3 expression was closely associated with lymph node metastasis of gastric cancer. In the present study, we detected the expression of PRL-3 in primary gastric cancer tissue, and evaluated its prognostic impact on the patients.
  
  
  METHODS
  Total 137 gastric tumor samples were measured for PRL-3 phosphatase expression using immunohistochemistry method, and the overall survival rate was compared between the patients with high PRL-3 expression (n = 85) and those with moderate or low PRL-3 expression (n = 52) in the primary tumor.
  
  
  RESULTS
  PRL-3 expression was more frequently detected in the tumors with a diameter >40 mm and in advanced stages (TNM stage III or IV). Furthermore, the overall survival rate of the patients with high expression of PRL-3 in the primary tumor was significantly less than those with moderate or low expression (P < 0.001).
  
  
  CONCLUSIONS
  PRL-3 expression is associated with gastric cancer progression. Its high expression in the primary lesion had a negative impact on the prognosis of the patients. This strongly suggests that PRL-3 should be considered as a prognostic factor.
authors.affiliation: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Sun Yat-sen University, 510080 Guangzhou, China.
authors.forename: Zhao
authors.initials: Z
authors.lastname: Wang
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Cai
authors.forename: Yu-Long
authors.initials: YL
authors.lastname: He
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhan
authors.forename: Chang-Hua
authors.initials: CH
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Wu
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Peng
authors.forename: Jian-Bo
authors.initials: JB
authors.lastname: Xu
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Zhang
authors.forename: Liang
authors.initials: L
authors.lastname: Wang
authors.forename: Wu
authors.initials: W
authors.lastname: Song
mesh_terms: D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D011379:Prognosis; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology*
chemical_list: D009363:Neoplasm Proteins; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases