In vitro anti-influenza viral activities of constituents from Caesalpinia sappan.
Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 microg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 microg/mL, respectively.
Liu
Ai-Lin
AL
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
Shu
Shi-Hui
SH
Qin
Hai-Lin
HL
Lee
Simon Ming Yuen
SM
Wang
Yi-Tao
YT
Du
Guan-Hua
GH
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D029911:Caesalpinia / Q000737:chemistry*; D002460:Cell Line; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009980:Influenza A virus / Q000187:drug effects*; D009981:Influenza B virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D010936:Plant Extracts