Lymphatic endothelial differentiation: start out with Sox--carry on with Prox.
The transcription factor Prox1 is the master regulator of lymphatic endothelial cell differentiation and its expression initiates the morphogenesis of the lymphatic vasculature in the early embryo. Two new studies now answer some fundamental questions concerning Prox1 biology.
Kiefer
Friedemann
F
Max-Planck-Institute for Molecular Biomedicine, Department of Vascular Cell Biology, D-48149 Münster, Germany.
Adams
Ralf H
RH
D000818:Animals; D002454:Cell Differentiation; D004730:Endothelium, Vascular / Q000166:cytology*; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D008208:Lymphatic System / Q000196:embryology; D042601:Lymphatic Vessels / Q000166:cytology* / Q000196:embryology; D055760:SOXF Transcription Factors / Q000378:metabolism*
D018398:Homeodomain Proteins; D055760:SOXF Transcription Factors