Stability and rupture of archaebacterial cell membrane: a model study.
It is known that the thermoacidophilic archaebacterium Sulfolobus acidocaldarius can grow in hot springs at 65-80 degrees C and live in acidic environments (pH 2-3); however, the origin of its unusual thermal stability remains unclear. In this work, using a vesicle as a model, we study the thermal stability and rupture of archaebacterial cell membrane. We perform a simulation investigation of the structure-property relationship of monolayer membrane formed by bolaform lipids and compare it with that of bilayer membrane formed by monopolar lipids. The origin of the unusually thermal stability of archaebacterial cell and the mechanism for its rupture are presented in molecular details.
Li
Shuangyang
S
Beijing University of Chemical Technology, Beijing 100029, China.
Zheng
Fengxian
F
Zhang
Xianren
X
Wang
Wenchuan
W
D001105:Archaea / Q000737:chemistry* / Q000502:physiology; D002462:Cell Membrane / Q000737:chemistry*; D004355:Drug Stability; D004777:Environment; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry; D008563:Membrane Lipids / Q000737:chemistry / Q000502:physiology; D008958:Models, Molecular; D008968:Molecular Conformation; D016945:Sulfolobus acidocaldarius / Q000737:chemistry* / Q000502:physiology; D013816:Thermodynamics
D008051:Lipid Bilayers; D008081:Liposomes; D008563:Membrane Lipids