title: Effect of selenium deficiency on the antioxidative status and muscle damage in growing turkeys.
abstract: An experiment investigated the effect of different selenium supplementations on the antioxidant defence system and on the occurrence of muscle dystrophy in growing turkeys. Newly hatched male turkeys (B.U.T. Big 6) were divided into eight groups of 18 turkeys each and fed either a basal diet (selenium < 0.010 mg/kg diet), or the basal diet supplemented with 0.10; 0.15; 0.20; 0.25; 0.30; 0.35 or 0.40 mg selenium/kg diet in the form of sodium selenate. Vitamin E was adequately supplemented in all diets. After 35 days, muscle damage parameters including aspartate aminotransferase, creatine kinase, creatine kinase M and B were significantly increased in the selenium deficient Group I. A significant reduction of weight gain, feed consumption and selenium dependent glutathione peroxidase activity was also observed in the liver of selenium deficient birds. The ratio of oxidised glutathione (GSSG) to total glutathione (tGSH) was substantially altered in the selenium deficient Group I as well as in Group II (0.10 mg selenium/kg feed). The activity of glutathione reductase (GR) and glutathione-S-transferase (GST) was not affected by selenium deficiency.
authors.affiliation: Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University Giessen, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Fischer
authors.forename: Astrid
authors.initials: A
authors.lastname: Bosse
authors.forename: Josef
authors.initials: J
authors.lastname: Pallauf
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D003402:Creatine Kinase / Q000378:metabolism; D052276:Creatine Kinase, BB Form; D052283:Creatine Kinase, MM Form; D004305:Dose-Response Relationship, Drug; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000201:enzymology; D008297:Male; D009133:Muscular Atrophy / Q000378:metabolism / Q000662:veterinary*; D009751:Nutritional Requirements; D009752:Nutritional Status; D010084:Oxidation-Reduction; D011201:Poultry Diseases / Q000378:metabolism*; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood / Q000172:deficiency*; D014422:Turkeys / Q000254:growth & development* / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D052276:Creatine Kinase, BB Form; D052283:Creatine Kinase, MM Form; D012643:Selenium