title: Unprecedented carbon-carbon bond cleavage in nucleophilic aziridine ring opening reaction, efficient ring transformation of aziridines to imidazolidin-4-ones.
abstract: N-Styryl-3-aryl-1-methylaziridine-2-carboxamides, which were readily obtained from the cross coupling reaction between 3-aryl-1-methylaziridine-2-carboxamides and 1-aryl-2-bromoethenes catalyzed by CuI/N,N-dimethylglycine in the presence of Cs(2)CO(3), underwent a base-mediated intramolecular nucleophilic aziridine ring opening reaction effectively via the carbon-carbon bond cleavage of aziridine to afford the ring expanded imidazolidin-4-one products in good yields.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Laboratory of Chemical Biology, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: Wang
authors.forename: Yuan
authors.initials: Y
authors.lastname: Hu
authors.forename: De-Xian
authors.initials: DX
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Pan
authors.forename: Zhi-Tang
authors.initials: ZT
authors.lastname: Huang
authors.forename: Mei-Xiang
authors.initials: MX
authors.lastname: Wang