title: [Detection of chromosomal aberration in sporadic colorectal cancer with comparative genomic hybridization].
abstract: OBJECTIVE
  To investigate the chromosomal aberration in sporadic colorectal carcinoma and its association with clinicopathological features.
  
  
  METHODS
  Comparative genomic hybridization(CGH) was used to screen the changes in the number of DNA sequence copies in 40 sporadic colorectal cancer patients in order to identify regions that contain genes important for the development and progression of colorectal cancer.
  
  
  RESULTS
  In 40 sporadic colorectal cancer, frequent gain at 20 q, 12 q, 13 q, 7 p, 7 q and 16 q were found, while loss was also found at 18 q, 5 q, 4 q, 8 pand 17 p. The number of chromosomal aberration was closely associated with tumor stage(P<0.05). No significant association was found between the number of chromosomal aberration and tumor site, histopathologic type and histologic grade.
  
  
  CONCLUSIONS
  Chromosomal aberration exists generally in sporadic colorectal carcinoma. The number of chromosomal aberration and gain of 20q are closely associated with tumor stage.
authors.affiliation: Department of Colorectal Cancer, Zhejiang Provincial Cancer Hospital, Hangzhou 310022, China.
authors.forename: Yin-Bo
authors.initials: YB
authors.lastname: Chen
authors.forename: Hai-Xing
authors.initials: HX
authors.lastname: Ju
authors.forename: Su-Zhan
authors.initials: SZ
authors.lastname: Zhang
authors.forename: Jia-Ping
authors.initials: JP
authors.lastname: Peng
authors.forename: De-Chuan
authors.initials: DC
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D055028:Comparative Genomic Hybridization; D015342:DNA Probes; D005260:Female; D018628:Gene Dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020411:Oligonucleotide Array Sequence Analysis
chemical_list: D015342:DNA Probes