title: Preparation and drug controlled-release of polyion complex micelles as drug delivery systems.
abstract: Block copolymers, poly(N-vinylprrolidone)-block-poly(styrene-alter-maleic anhydride) (PVP-b-PSMA) and poly(N-vinylprrolidone)-block-poly(N,N-dimethylaminoethyl methacrylate) (PVP-b-PDMAEMA), were synthesized by reversible addition- fragmentation chain transfer (RAFT) polymerization. In aqueous media, this a pair of oppositely-charged diblock copolymers could self-assemble into stable and narrow distribution polyion complex micelles (PICMs). Transmission electron micrographs (TEM) and dynamic light scattering (DLS) analysis showed that the micelles to be spherically shaped with mean hydrodynamic diameter around 70nm. In addition, the PICMs display ability to response to external stimuli. All of theses features are quite feasible for utilizing it as a novel intelligent drug delivery system. In order to assess its application in biomedical area, release profiles of coenzyme A (Co A) from PICMs were studied under both simulated gastric and intestinal pH conditions. The release was much quicker in pH 7.4 buffer than in pH 2.0 solution. Based on these results, these PICMs could be a potential pH-sensitive carrier for colon-specific drug delivery system.
authors.affiliation: Institute of Fine Chemical and Engineering, Henan University, Kaifeng, Henan 475001, P R China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Luo
authors.forename: Xinjian
authors.initials: X
authors.lastname: Yao
authors.forename: Jinfang
authors.initials: J
authors.lastname: Yuan
authors.forename: Tao
authors.initials: T
authors.lastname: Ding
authors.forename: Qingyu
authors.initials: Q
authors.lastname: Gao
mesh_terms: D002021:Buffers; D002850:Chromatography, Gel; D003065:Coenzyme A / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D008970:Molecular Weight; D009757:Nylons / Q000737:chemistry; D010316:Particle Size; D004364:Pharmaceutical Preparations; D011108:Polymers / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002021:Buffers; D003692:Delayed-Action Preparations; D008689:Methacrylates; D008823:Micelles; D009757:Nylons; D004364:Pharmaceutical Preparations; D011108:Polymers; C407037:poly(2-(dimethylamino)ethyl methacrylate); D003065:Coenzyme A