Rifamycin S and its geometric isomer produced by a newly found actinomycete, Micromonospora rifamycinica.
Strain AM105 was separated from mangrove sediment in the South China Sea in this research. The morphological and genomic data showed that the strain merits description as a novel species, proposed as Micromonospora rifamycinica. From the acetate ethyl extract of its fermentation broth, two antibiotics against Gram-positive bacteria (including MRSA), rifamycin S and its geometric isomer were isolated. Their structures were elucidated on the basis of spectroscopic analyzes. (1)H and (13)C NMR data of the isomer of rifamycin S were first described in this paper.
Huang
Huiqin
H
Key Laboratory of Tropical Crop Biotechnology of Agriculture Ministry, Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China. huanghq21@yahoo.com.cn
Wu
Xiaopeng
X
Yi
Sheng
S
Zhou
Zhiwang
Z
Zhu
Jun
J
Fang
Zhe
Z
Yue
Jianmin
J
Bao
Shixiang
S
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D002681:China; D019015:Geologic Sediments / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000145:classification* / Q000166:cytology / Q000302:isolation & purification / Q000378:metabolism*; D015394:Molecular Structure; D012294:Rifamycins / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D012294:Rifamycins; C032779:rifamycin S