[Prognostic factors of medullary thyroid carcinoma].
OBJECTIVE
To investigate prognostic factors of medullary thyroid carcinoma.


METHODS
By using univariate analysis and multivariate analysis, the prognostic factors were investigated in 102 patients with medullary thyroid carcinoma treated at this hospital.


RESULTS
Overall survival rates of 5-year, 10-year and 15-year were 87.4%, 74.6% and 54.2% respectively by Kaplan-Meier method analysis. In univariate analysis, gender, age, bilateral thyroid lobe tumors, tumor size > 4 cm, invasion of thyroid capsule, distant metastasis, and non-radical tumor resection were significant poor prognostic factors. In multivariate analysis, tumor size > 4 cm (chi(2) = 7.43, P = 0.0035), distant metastasis (chi(2) = 23.50, P = 0.0000), and non-radical tumor resection (chi(2) = 25.90, P = 0.0000) remained as independent prognostic factors.


CONCLUSIONS
Tumor size > 4 cm, distant metastasis, and non-radical tumor resection are the independent predictors of patients survival. Early diagnosis and early therapy can improve significantly the prognosis of medullary thyroid carcinoma.
Zhang
Quan
Q
Department of Head and Neck Surgery, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China. zhangq6@mail.sysu.edu.cn
Yang
Chuan-sheng
CS
Guo
Zhu-ming
ZM
Zeng
Zong-yuan
ZY
Yang
An-kui
AK
Lai
Fei-yun
FY
D000293:Adolescent; D000328:Adult; D000368:Aged; D018276:Carcinoma, Medullary / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D002648:Child; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D055815:Young Adult