Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue.
Increased oxidative stress in adipocytes causes dysregulated expression of inflammation-related adipokines. We have examined the effects of exercise training on oxidative stress in rat white adipose tissue (WAT), especially focusing on inflammation-related adipokines. The levels of lipid peroxidation in WAT of exercise-trained (TR) rats were lower than those in control (C) rats. The content of manganese-containing superoxide dismutase in WAT of TR rats was increased as compared with those in C rats. In contrast, the expression of the NADPH oxidase NOX2 protein in WAT was downregulated by exercise training. Moreover, the levels of inflammation-related adipokines, such as tumor necrosis factor-alpha and monocyte chemoattractant protein-1, in WAT of TR rats were lower than those in C rats. The effects of exercise training were more remarkable in visceral WAT than in subcutaneous. These results suggest that exercise training decreases the expression of inflammation-related adipokines by reducing oxidative stress in WAT.
Sakurai
Takuya
T
Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo 181-8611, Japan. sakutaku@kyorin-u.ac.jp
Izawa
Tetsuya
T
Kizaki
Takako
T
Ogasawara
Jun-etsu
JE
Shirato
Ken
K
Imaizumi
Kazuhiko
K
Takahashi
Kazuto
K
Ishida
Hitoshi
H
Ohno
Hideki
H
D054392:Adipokines / Q000096:biosynthesis*; D052436:Adipose Tissue, White / Q000378:metabolism*; D000818:Animals; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D007249:Inflammation / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000096:biosynthesis; D018384:Oxidative Stress / Q000502:physiology*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
D054392:Adipokines; D008562:Membrane Glycoproteins; D013482:Superoxide Dismutase; C500593:Cybb protein, rat; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases; D048049:Extracellular Signal-Regulated MAP Kinases