Efficacy of intracerebral delivery of Carboplatin in combination with photon irradiation for treatment of F98 glioma-bearing rats.
OBJECTIVE
To evaluate the efficacy of prolonged intracerebral (i.c.) administration of carboplatin by means of ALZET osmotic pumps, in combination with radiotherapy for the treatment of intracranial F98 glioma in rats.


METHODS
Seven days after stereotactic implantation of F98 glioma cells into the brains of Fischer rats, carboplatin was administrated i.c. by means of ALZET pumps over 6 days. Rats were treated at the European Synchrotron Radiation Facility with a single 15-Gy X-ray dose, either given alone or 24 h after administration of carboplatin.


RESULTS
Untreated rats had a mean survival time (MST) +/- SE of 23 +/- 1 days, compared with 44 +/- 3 days for X-irradiated animals and 69 +/- 20 days for rats that received carboplatin alone, with 3 of 13 of these surviving >195 days. Rats that received carboplatin followed by X-irradiation had a MST of >142 +/- 21 days and a median survival time of >195 days, with 6 of 11 rats (55%) still alive at the end of the study. The corresponding percentage increases in lifespan, based on median survival times, were 25%, 85%, and 713%, respectively, for carboplatin alone, radiotherapy alone, or the combination.


CONCLUSIONS
Our data demonstrate that i.c. infusion of carboplatin by means of ALZET pumps in combination with X-irradiation is highly effective for the treatment of the F98 glioma. They provide strong support for the approach of concomitantly administering chemo- and radiotherapy for the treatment of brain tumors.
Rousseau
Julia
J
Institut National de la Santé et de la Recherche Médicale U836, Equipe 6, Grenoble, France.
Barth
Rolf F
RF
Moeschberger
Melvin L
ML
Elleaume
Hélène
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D016190:Carboplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods; D005910:Glioma / Q000188:drug therapy* / Q000532:radiotherapy*; D007260:Infusion Pumps; D008297:Male; D017785:Photons / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D011916:Rats, Inbred F344; D016019:Survival Analysis
D000970:Antineoplastic Agents; D016190:Carboplatin