title: Ovarian tumor in a 12-year old female with severe hypothyroidism: A case of Van Wyk and Grumbach syndrome.
abstract: We report a 12-year-old female presenting with an abdominal tumor. Diagnostic workup revealed giant bilateral ovarian cysts, severe hypothyroidism as well as an elevation of CA 125. We refrained from ovariectomy, which would be necessary for a malignant tumor, in view of an evident Van Wyk and Grumbach syndrome. The patient promptly responded to L-thyroxine with complete regression of all symptoms. Hypothyroidism should be considered in the evaluation of ovarian cysts. Although the Van Wyk and Grumbach syndrome is rare, it is crucial to rule it out in order to avoid unnecessary ovarian surgery when thyroid replacement is completely sufficient.
authors.affiliation: Department of Pediatric Hematology and Oncology, Center of Child and Adolescent, Medicine, Justus-Liebig-University Giessen, Giessen, Germany. andrea.hunold@paediat.med.uni-giessen.de
authors.forename: Andrea
authors.initials: A
authors.lastname: Hunold
authors.forename: Gerhard
authors.initials: G
authors.lastname: Alzen
authors.forename: Stefan A
authors.initials: SA
authors.lastname: Wudy
authors.forename: Renate
authors.initials: R
authors.lastname: Bluetters-Sawatzki
authors.forename: Eva
authors.initials: E
authors.lastname: Landmann
authors.forename: Alfred
authors.initials: A
authors.lastname: Reiter
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Wagner
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D010048:Ovarian Cysts / Q000150:complications* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D010052:Ovariectomy; D013577:Syndrome; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine