Micropatterned surfaces with covalently grafted unsymmetrical polyoxometalate-hybrid clusters lead to selective cell adhesion.
Mn-Anderson based polyoxometalate clusters with different terminal groups have been patterned successfully onto self-assembled monolayer (SAM) using microcontact printing. Studies of the interactions between the designed SAMs and human fibroblast (hTERT-BJ1) cells have been reported, and it was observed that cells attach and spread efficiently for monolayer presenting a terminal aromatic pyrene platform with a polyoxometalate Mn-Anderson cluster as linker, demonstrating the crucial role played by the polyoxometalate metal oxide cluster as an intermediary in cell adhesion to the surface.
Song
Yu-Fei
YF
WestCHEM Department of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ UK.
McMillan
Nicola
N
Long
De-Liang
DL
Kane
Struan
S
Malm
Jakob
J
Riehle
Mathis O
MO
Pradeep
Chullikkattil P
CP
Gadegaard
Nikolaj
N
Cronin
Leroy
L
D002448:Cell Adhesion; D002460:Cell Line; D006801:Humans; D008855:Microscopy, Electron, Scanning; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013499:Surface Properties; D017973:Tungsten Compounds / Q000737:chemistry*; D000099294:Polyoxometalates
D017973:Tungsten Compounds; C102296:polyoxometalate I; D000099294:Polyoxometalates