title: Endoscopic laser surgery of early glottic cancer: involvement of the anterior commissure.
abstract: BACKGROUND
  Early glottic cancer can be cured with transoral laser resection, but in cases with anterior commissure involvement, there is still controversy concerning the best treatment modality.
  
  
  METHODS
  The impact of anterior commissure involvement on local control was analyzed in a retrospective review of 444 patients with early glottic cancer (pT1a-pT2a) treated between 1986 and 2004 with transoral laser microsurgical resection.
  
  
  RESULTS
  The anterior commissure was involved in 153 cases; the 5-year local control rate with and without anterior commissure involvement was 73% versus 89% for T1a and 68% versus 86% for T1b tumors. For T2a lesions, the 5-year local control rate was 76%, irrespective of anterior commissure involvement.
  
  
  CONCLUSIONS
  In early glottic cancer treated by transoral laser microsurgery, a decrease in local control is evident in case of anterior commissure involvement for T1a and T1b but not for T2a tumors.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Göttingen, Göttingen, Germany. rroedel@med.uni-goettingen.de
authors.forename: Ralph M W
authors.initials: RM
authors.lastname: Rödel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Steiner
authors.forename: Roland M
authors.initials: RM
authors.lastname: Müller
authors.forename: Martina
authors.initials: M
authors.lastname: Kron
authors.forename: Christoph
authors.initials: C
authors.lastname: Matthias
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D005931:Glottis / Q000601:surgery*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007828:Laryngoscopy; D053685:Laser Therapy; D054020:Lasers, Gas; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D018365:Neoplasm, Residual / Q000601:surgery; D011183:Postoperative Complications; D012189:Retrospective Studies; D016879:Salvage Therapy