title: Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism.
abstract: OBJECTIVE
  To compared the plasma levels and the genetic polymorphism of myeloperoxidase in patients with pelvic inflammatory disease (PID) and healthy controls.
  
  
  METHODS
  A random consecutive study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Forty-four women who were diagnosed with PID.
  
  
  METHODS
  Collected blood specimens of patients before and after they received treatment.
  
  
  METHODS
  ELISA and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma levels and genetic polymorphism of myeloperoxidase.
  
  
  RESULTS
  We found the plasma level of myeloperoxidase was elevated in PID patients compared with that in normal controls and decreased significantly compared with that in the same patients after they received treatment. PID patients with myeloperoxidase G/A alleles significantly tended to have elevated plasma concentration of myeloperoxidase, whereas PID patients with G/G homozygous alleles did not.
  
  
  CONCLUSIONS
  Elevated expression of myeloperoxidase may be involved in the pathogenesis of PID and could be useful for the diagnosis of PID. Furthermore, G/A alleles of myeloperoxidase may contribute to such elevation in PID patients.
authors.affiliation: Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
authors.forename: Shun-An
authors.initials: SA
authors.lastname: Lee
authors.forename: Po-Hui
authors.initials: PH
authors.lastname: Wang
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Chiou
authors.forename: Ming-Chin
authors.initials: MC
authors.lastname: Chou
authors.forename: Hsiu-Ting
authors.initials: HT
authors.lastname: Tsai
authors.forename: Shun-Fa
authors.initials: SF
authors.lastname: Yang
mesh_terms: D000225:Adenine; D000483:Alleles; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D000292:Pelvic Inflammatory Disease / Q000097:blood / Q000201:enzymology* / Q000235:genetics*; D009195:Peroxidase / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D015415:Biomarkers; D009195:Peroxidase; D000225:Adenine