title: Gastrointestinal stromal tumor of the gastric serosa protruding to the greater omentum. Report of a giant tumor with a rare histological pattern.
abstract: We report an unusual case of a 76 year old woman admitted to our hospital for investigation of anemia and palpable epigastric mass. Intraoperatively a huge (19 cm), well defined tumor was found adhering to the stomach wall, protruding into the greater omentum and compressing the transverse colon. A tumorectomy was performed and the greater omentum was removed due to its close relation. Pathology revealed a high risk Gastrointestinal Stromal tumor of the gastric serosa. Histologically the tumor was of mixed type (spindle and epithelioid cells) with hem-angio-peri-cytomatoid pattern peripherally, variably myxoid stroma, central necrosis and cytologic pleomorphism. On immunohistochemical examination there was a consistent positivity for c-kit (CD-117) and CD-34, but without myogenic or neural differentiation. We consider this case unusual because of its huge size, its gastric serosal location and its extremely rare histological pattern.
authors.affiliation: 2nd Department of Surgery, Asclepeion General Hospital, Athens, Greece.
authors.forename: Emmanouel
authors.initials: E
authors.lastname: Pavlakis
authors.forename: Efthimios
authors.initials: E
authors.lastname: Avgerinos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Stathoulopoulos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Godevenos
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Diamantopoulou
authors.forename: Euphemia
authors.initials: E
authors.lastname: Thomas-Tsagli
authors.forename: Nicolas
authors.initials: N
authors.lastname: Condilis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Smailis
authors.forename: Efstratios
authors.initials: E
authors.lastname: Christianakis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsatsoulis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Skandalakis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Filippou
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000276:immunology; D014408:Biomarkers, Tumor / Q000276:immunology; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D009852:Omentum / Q000473:pathology / Q000601:surgery; D019009:Proto-Oncogene Proteins c-kit / Q000276:immunology; D012704:Serous Membrane / Q000473:pathology*; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019009:Proto-Oncogene Proteins c-kit