title: A feasibility study of induction pemetrexed plus cisplatin followed by extrapleural pneumonectomy and postoperative hemithoracic radiation for malignant pleural mesothelioma.
abstract: A prospective multi-institutional study has been commenced in Japan to evaluate the feasibility of induction chemotherapy using pemetrexed plus cisplatin, followed by extrapleural pneumonectomy (EPP) and postoperative hemithoracic radiation in patients with resectable malignant pleural mesothelioma. The study was initiated on May 2008 and 40 patients will be recruited over 3 years. Primary endpoints are macroscopic complete resection rate by EPP and treatment-related mortality for trimodality therapy. Secondary endpoints include treatment completion rate, adverse events, response rate by chemotherapy and 2-year overall and relapse-free survival.
authors.affiliation: Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo, Japan.
authors.forename: Takeharu
authors.initials: T
authors.lastname: Yamanaka
authors.forename: Fumihiro
authors.initials: F
authors.lastname: Tanaka
authors.forename: Seiki
authors.initials: S
authors.lastname: Hasegawa
authors.forename: Morihito
authors.initials: M
authors.lastname: Okada
authors.forename: Toshinori
authors.initials: T
authors.lastname: Soejima
authors.forename: Norihiko
authors.initials: N
authors.lastname: Kamikonya
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fukuoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001499:Bayes Theorem; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage; D023381:Endpoint Determination; D005240:Feasibility Studies; D005260:Female; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D007564:Japan; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D018579:Patient Selection; D000068437:Pemetrexed; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D011013:Pneumonectomy / Q000379:methods; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012074:Remission Induction; D012107:Research Design; D018401:Sample Size
chemical_list: D005971:Glutamates; D000068437:Pemetrexed; D006147:Guanine; D002945:Cisplatin