title: Difficulty in improving malnutrition and low-grade inflammation in diabetic patients on peritoneal dialysis.
abstract: Continuous ambulatory peritoneal dialysis (CAPD) is commonly used for renal replacement therapy in diabetes mellitus (DM) patients. We investigated the changes of peritoneal transport characteristics, nutritional status, and adequacy and inflammation parameters in diabetic CAPD patients (N = 17) compared to non-diabetic patients (N = 23). Peritoneal equilibrium testing, nutritional, biochemical, and anthropometric parameters and adequacy were prospectively assessed at 1 (baseline), 6 and 12 months after initiating CAPD. The levels of several nutritional parameters were lower and did not change in DM patients over time (P < 0.05) and significantly improved in the non-DM patients over time (P < 0.05). Total weekly creatinine clearance and residual renal function exhibited a rapid decline (P < 0.05) and inflammation parameter levels were higher in DM patients (P < 0.05). Our results showed the difficulty in improvement of nutritional status and inflammatory parameters in diabetic patients during at least the first year of CAPD compared to non-DM patients.
authors.affiliation: Department of Internal Medicine, Kyungpook University Hospital, Daegu, South Korea.
authors.forename: Sung-Won
authors.initials: SW
authors.lastname: Park
authors.forename: Jung-Ju
authors.initials: JJ
authors.lastname: Seo
authors.forename: Ho-Sang
authors.initials: HS
authors.lastname: Bae
authors.forename: Jong-Yeon
authors.initials: JY
authors.lastname: Kim
authors.forename: Chan-Duck
authors.initials: CD
authors.lastname: Kim
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Park
authors.forename: Yong-Lim
authors.initials: YL
authors.lastname: Kim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003404:Creatinine / Q000097:blood / Q000652:urine; D003928:Diabetic Nephropathies / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000628:therapy; D007677:Kidney Function Tests; D008297:Male; D044342:Malnutrition / Q000453:epidemiology / Q000209:etiology; D008875:Middle Aged; D009752:Nutritional Status; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010537:Peritoneum / Q000378:metabolism; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D003404:Creatinine