Evaluation of polyethylene oxide compacts as gastroretentive delivery systems.
Compacts containing selected bioadhesive polymers, fillers, and binders were investigated for their potential as a bioadhesive gastroretentive delivery system to deliver water soluble and water insoluble compounds in the stomach. Compacts with 90:10, 75:25, and 60:40 of polyvinylpyrrolidone (PVP) and polyethylene oxide (PEO) were evaluated for swelling, dissolution, bioadhesion, and in vitro gastric retention. Compacts containing higher PEO showed higher swelling (111.13%) and bioadhesion (0.62 +/- 0.03 N/cm(2)), and retained their integrity and adherence onto gastric mucosa for about 9 h under in vitro conditions. In vivo gastroretentive property of compacts were evaluated in Yorkshire cross swine. Compacts containing 58% PVP, 40% PEO and 2% of water soluble or water insoluble marker compounds showed gastroadhesive and retentive properties in vivo. It is concluded that PEO in combination with PVP yields a non disintegrating type bioadhesive dosage form which is suitable for gastroretentive applications.
Mahalingam
Ravichandran
R
Department of Pharmaceutics and Medicinal Chemistry, T. J. Long School of Pharmacy and Health Sciences, University of the Pacific, 751 Brookside Road, Stockton, CA 95211, USA.
Jasti
Bhaskara
B
Birudaraj
Raj
R
Stefanidis
Dimitrios
D
Killion
Robert
R
Alfredson
Tom
T
Anne
Pratap
P
Li
Xiaoling
X
D000268:Adhesiveness; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004396:Coloring Agents / Q000378:metabolism; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D008297:Male; D008751:Methylene Blue / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D013552:Swine; D013678:Technology, Pharmaceutical / Q000379:methods
D004396:Coloring Agents; D004304:Dosage Forms; D004337:Drug Carriers; D011092:Polyethylene Glycols; D011205:Povidone; D008751:Methylene Blue