Effects of different levels of food restriction on passive-avoidance memory and the expression of synapsin I in young mice.
The present study investigated the effects of food restriction (FR) on memory and the expression of synapsin I in the brain of young mice. The results showed that 20% FR did not retard the body weight gain of mice, while the 60% and 80% FR reduced the mice's body weight. The memory after 24 hr of learning was not changed by FR, whereas long-term memory was improved significantly in 20% FR mice. In addition, 60% and 80% FR did not impair the mice's memory. The transcriptional expression of synapsin I in mice brain was up-regulated by 20% FR, and down-regulated by 60% and 80% FR.
Deng
L
L
School of Life Science, Shenzhen University, Shenzhen, Guangdong Province, China. lideng03@sina.com
Wu
Z-N
ZN
Han
P-Z
PZ
D000375:Aging / Q000378:metabolism; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001835:Body Weight / Q000502:physiology; D001921:Brain / Q000254:growth & development* / Q000378:metabolism*; D031204:Caloric Restriction / Q000379:methods; D015536:Down-Regulation / Q000502:physiology; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D008569:Memory Disorders / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D051379:Mice; D016704:Synapsins / Q000378:metabolism*; D015854:Up-Regulation / Q000502:physiology
D016704:Synapsins