title: Steroids from an Australian sponge Psammoclema sp.
abstract: Investigation of an extract of the Australian marine sponge Psammoclema sp. for dynamin I inhibitory activity led to the isolation of four new trihydroxysterols (1-4) related to aragusterol G. These compounds were largely identified by 1D and 2D NMR spectroscopic methods. While 1 was found to be inactive in the dynamin bioassay, bioassays did reveal that compounds 1-4 inhibited the growth of colorectal, breast, ovarian, and prostate cancer cell lines (GI(50) 5-27 microM). The additional insight that these new compounds give to previous SAR studies is discussed briefly.
authors.affiliation: Chemistry, School of Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia.
authors.forename: Ian P
authors.initials: IP
authors.lastname: Holland
authors.forename: Adam
authors.initials: A
authors.lastname: McCluskey
authors.forename: Jennette A
authors.initials: JA
authors.lastname: Sakoff
authors.forename: Jayne
authors.initials: J
authors.lastname: Gilbert
authors.forename: Ngoc
authors.initials: N
authors.lastname: Chau
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Robinson
authors.forename: Cherie A
authors.initials: CA
authors.lastname: Motti
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
authors.forename: Ian A
authors.initials: IA
authors.lastname: van Altena
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001315:Australia; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids