title: Effects of bromazepam in frontal theta activity on the performance of a sensorimotor integration task: a quantitative electroencephalography study.
abstract: Our objective is to verify the modulatory effects of bromazepam on EEG theta absolute power when subjects were submitted to a visuomotor task (i.e., car driver task). Sample was composed of 14 students (9 males and 5 females), right handed, with ages varying between 23 and 42 years (mean=32.5+/-9.5), absence of mental or physical impairments, no psychoactive or psychotropic substance use and no neuromuscular disorders (screened by a clinical examination). The results showed an interaction between condition and electrodes (p=0.034) in favor of F8 electrode compared with F7 in both experimental conditions (t-test; p=0.001). Additionally, main effects were observed for condition (p=0.001), period (p=0.001) and electrodes (p=0.031) in favor of F4 electrode compared with F3. In conclusion, Br 6mg of bromazepam may interfere in sensorimotor processes in the task performance in an unpredictable scenario allowing that certain visuospatial factors were predominant. Therefore, the results may reflect that bromazepam effects influence the performance of the involved areas because of the acquisition and integration of sensory stimuli processes until the development of a motor behavior based on the same stimuli.
authors.affiliation: Brain Mapping and Sensory Motor Integration, Institute of Psychiatry of Federal University of Rio de Janeiro, Brazil.
authors.forename: Sander
authors.initials: S
authors.lastname: Fridman
authors.forename: Sergio
authors.initials: S
authors.lastname: Machado
authors.forename: Marlo
authors.initials: M
authors.lastname: Cunha
authors.forename: Bruna
authors.initials: B
authors.lastname: Velasques
authors.forename: Fernando
authors.initials: F
authors.lastname: Pompeu
authors.forename: Henning
authors.initials: H
authors.lastname: Budde
authors.forename: Mauricio
authors.initials: M
authors.lastname: Cagy
authors.forename: Luis F
authors.initials: LF
authors.lastname: Basile
authors.forename: Roberto
authors.initials: R
authors.lastname: Piedade
authors.forename: Pedro
authors.initials: P
authors.lastname: Ribeiro
mesh_terms: D000328:Adult; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001960:Bromazepam / Q000494:pharmacology*; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology; D004569:Electroencephalography; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D009068:Movement / Q000187:drug effects* / Q000502:physiology; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000187:drug effects* / Q000502:physiology; D013028:Space Perception / Q000187:drug effects* / Q000502:physiology; D013826:Theta Rhythm / Q000187:drug effects*; D055815:Young Adult
chemical_list: D014151:Anti-Anxiety Agents; D001960:Bromazepam