title: Targeting of cancer energy metabolism.
abstract: The main purpose of this review is to update and analyze the effect of several antineoplastic drugs (adriamycin, apoptodilin, casiopeinas, cisplatin, clotrimazole, cyclophosphamide, ditercalinium, NSAIDs, tamoxifen, taxol, 6-mercaptopurine, and alpha-tocopheryl succinate) and energy metabolism inhibitors (2-DOG, gossypol, delocalized lipophilic cations, and uncouplers) on tumor development and progression. The possibility that these antineoplastic drugs currently used in in vitro cancer models, in chemo-therapy, or under study in phase I to III clinical trials induce tumor cellular death by altering also metabolite concentration (i.e., ATP), enzyme activities, and/or energy metabolism fluxes is assessed. It is proposed that the use of energy metabolic therapy, as an alternative or complementary strategy, might be a promising novel approach in the treatment of cancer.
authors.affiliation: Departamento de Bioquímica, Instituto Nacional de Cardiología, Tlalpan, Mexico, Mexico. sara.rodriguez@cardiologia.org.mx
authors.forename: Sara
authors.initials: S
authors.lastname: Rodríguez-Enríquez
authors.forename: Alvaro
authors.initials: A
authors.lastname: Marín-Hernández
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Gallardo-Pérez
authors.forename: Liliana
authors.initials: L
authors.lastname: Carreño-Fuentes
authors.forename: Rafael
authors.initials: R
authors.lastname: Moreno-Sánchez
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006019:Glycolysis / Q000187:drug effects; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D014475:Uncoupling Agents / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D014475:Uncoupling Agents; D002945:Cisplatin