Effect of thymoptin on hemostasis and fibrinolysis in rats with experimental nephritis.
Immune nephritis in rats was induced by administration of nephrotoxic rabbit antiserum. The development of severe renal inflammation (proteinuria, edema, lipemia, increased erythrocyte sedimentation rate, and 30% mortality) was accompanied by hypercoagulation and inhibition of fibrinolysis. Repeated subcutaneous injections of thymoptin in a low dose of 0.1 microg/200 g (5 injections every other day) increased the severity of inflammation and prethrombotic state of the blood. Lengthening the period between injections (5 injections at 5-day intervals) was followed by a tendency toward attenuation of nephritis and correction of hypercoagulation. In healthy rats, thymoptin produced an opposite effect on hemostasis, which was manifested in moderate stimulation of fibrinolysis and hypocoagulation.
Podorolskaya
L V
LV
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Russia.
Serebryakova
T N
TN
Andreenko
G V
GV
Raevskaya
A K
AK
D000818:Animals; D005342:Fibrinolysis / Q000187:drug effects* / Q000502:physiology; D006487:Hemostasis / Q000187:drug effects* / Q000502:physiology; D009393:Nephritis / Q000097:blood* / Q000473:pathology / Q000503:physiopathology; D011817:Rabbits; D051381:Rats; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology
C065652:timoptin; D013947:Thymosin