title: [The birth of biological therapy in Hungary: the story of László Meduna's first patient receiving convulsive therapy].
abstract: Convulsive treatment was introduced to psychiatry by László Meduna, a Hungarian neuropsychiatrist. In his autobiography, Meduna gave a detailed description of his first patient who underwent convulsive therapy. According to Meduna's recollections, this patient was L. Zoltán, who after 4 years of fluctuating catatonic stupor received several sessions of camphor-induced convulsive therapy resulting in full remission and discharge from the institution. In this communication, the authors reconstruct L Zoltán's case history from the original case notes, which were recovered from the Archives of the National Institute of Psychiatry and Neurology, Budapest. The case notes show that L. Zoltán received courses of convulsive treatment between 1934 and 1937, first induced with camphor and then with cardiazol. After the first course of treatment the catatonic stupor was resolved and the psychotic symptoms subsided. However, this incomplete remission lasted only for a few months and was followed by a relapse. Despite further courses of convulsive therapy, L. Zoltán never became symptom free again, could never be discharged and died in the institute in 1945. The authors attempt to explain possible reasons for the discrepancies found between Meduna's account and L. Zoltán's case notes.
authors.affiliation: Semmelweis Egyetem AOK Pszichiátriai és Pszichoterápiás Klinika. baran@psych.sote.hu
authors.forename: Brigitta
authors.initials: B
authors.lastname: Baran
authors.forename: István
authors.initials: I
authors.lastname: Bitter
authors.forename: Gábor S
authors.initials: GS
authors.lastname: Ungvári
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Nagy
authors.forename: Gábor
authors.initials: G
authors.lastname: Gazdag
mesh_terms: D001689:Biological Psychiatry / Q000266:history* / Q000379:methods; D002164:Camphor / Q000008:administration & dosage / Q000266:history*; D003292:Convulsants / Q000008:administration & dosage / Q000266:history*; D004334:Drug Administration Schedule; D049673:History, 20th Century; D006801:Humans; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000266:history*; D012560:Schizophrenia, Catatonic / Q000266:history* / Q000628:therapy; D012640:Seizures / Q000139:chemically induced / Q000266:history*; D016896:Treatment Outcome
chemical_list: D003292:Convulsants; D002164:Camphor; D010433:Pentylenetetrazole