Lymphoepithelial carcinoma of the maxillary sinus with orbital invasion.
Lymphoepithelial carcinoma (LEC) of the maxillary sinus is a very rare neoplasm that shares some characteristics with nasopharyngeal carcinoma. Epstein-Barr virus (EBV) has been reported to be associated with LEC located outside of the nasopharynx in Asian populations. A case report of a 64-year-old Asian female with right-sided cheek mass which was diagnosed preoperatively as a maxillary mass by paranasal sinus computed tomography scan is presented. Because maxillary sinus cancer with orbital invasion was considered, she underwent surgical removal of a mass. Final pathology revealed LEC, which is presented in our report. However, in situ hybridization assays returned negative results for Epstein-Barr virus. The patient underwent postoperative chemoradiotherapy, and has remained disease-free during 3-year follow-up. Although a few cases in the maxillary LEC have been reported, this is the first report describing the diagnosis and treatment of LEC occurred in the maxillary sinus. Surgical removal and adjuvant chemoradiotherapy may be useful in the treatment of more advanced maxillary LEC.
Jung
Hyun
H
Department of Otorhinolaryngology-Head and Neck Surgery, Inje University, College of Medicine, Pusan Paik Hospital, Busan, Republic of Korea.
Park
Seong Kook
SK
Heo
Kyung Wook
KW
Kang
Mi Seon
MS
D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005145:Face / Q000473:pathology; D005260:Female; D006801:Humans; D008444:Maxillary Sinus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009915:Orbit / Q000000981:diagnostic imaging* / Q000473:pathology*; D018714:Radiotherapy, Adjuvant; D040521:Subcutaneous Tissue / Q000473:pathology; D014057:Tomography, X-Ray Computed