title: Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol.
abstract: Clinical and metabolic variables were evaluated in 14 Labrador retrievers with exercise-induced collapse (EIC) before, during, and following completion of a standardized strenuous exercise protocol. Findings were compared with previously reported variables from 14 normal Labrador retrievers that participated in the same protocol. Ten of 14 dogs with EIC developed an abnormal gait during evaluation, and these dogs were significantly more tachycardic and had a more severe respiratory alkalosis after exercise compared to the normal dogs. Muscle biopsy characteristics and sequential lactate and pyruvate concentrations were normal. Genetic testing and linkage analysis excluded malignant hyperthermia as the cause of EIC. Common causes of exercise intolerance were eliminated, but the cause of collapse in EIC was not determined.
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada.
authors.forename: Susan M
authors.initials: SM
authors.lastname: Taylor
authors.forename: Cindy L
authors.initials: CL
authors.lastname: Shmon
authors.forename: Vicki J
authors.initials: VJ
authors.lastname: Adams
authors.forename: James R
authors.initials: JR
authors.lastname: Mickelson
authors.forename: Edward Ned E
authors.initials: EN
authors.lastname: Patterson
authors.forename: G Diane
authors.initials: GD
authors.lastname: Shelton
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D001774:Blood Chemical Analysis; D001831:Body Temperature; D002331:Carnitine / Q000032:analysis / Q000097:blood / Q000652:urine; D004283:Dog Diseases / Q000235:genetics / Q000503:physiopathology*; D004285:Dogs / Q000235:genetics / Q000502:physiology*; D005260:Female; D008297:Male; D008305:Malignant Hyperthermia / Q000662:veterinary; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D052097:Quadriceps Muscle / Q000601:surgery; D012146:Rest / Q000502:physiology; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D002331:Carnitine