title: [Effect of hydrostatic pressure on ultrastructure of synovial fibroblasts from rat temporomandibular joint].
abstract: OBJECTIVE
  To investigate the role of apoptosis in the remodeling of temporomandibular joint (TMJ) under pressure.
  
  
  METHODS
  Synovial fibroblasts obtained from rat temporomandibular joint were subjected to different hydrostatic pressure for 12 h. Changes of ultrastructure were observed by transmission electron microscope.
  
  
  RESULTS
  At 30 kPa, the ultrastructure of synovial fibroblasts showed no obvious changes. At 60 kPa, the chromatin was condensated, the baryon took on crescent and the mitochondria seemed varicose. At 90 kPa, the apoptosis-like body was wrapped by membrane and embedded in the high density chromatin.
  
  
  CONCLUSIONS
  Apoptosis-like change took place in ultrastructure of synovial fibroblasts under hydrostatic pressure, and the degree of the change was related to the hydrostatic pressure exerted.
authors.affiliation: Department of Orthodontics, Hospital of Stomatology, Zhejiang University, Hangzhou, China.
authors.forename: Meng-Jie
authors.initials: MJ
authors.lastname: Wu
authors.forename: Jian-Ying
authors.initials: JY
authors.lastname: Feng
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Gu
mesh_terms: D000818:Animals; D017209:Apoptosis; D005347:Fibroblasts / Q000648:ultrastructure*; D006874:Hydrostatic Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D013583:Synovial Membrane / Q000166:cytology; D013704:Temporomandibular Joint / Q000166:cytology