Is there an association with constitutional structural chromosomal abnormalities and hematologic neoplastic process? A short review.
The occasional observation of constitutional chromosomal abnormalities in patients with a malignant disease has led to a number of studies on their potential role in cancer development. Investigations of families with hereditary cancers and constitutional chromosomal abnormalities have been key observations leading to the molecular identification of specific genes implicated in tumorigenesis. Large studies have been reported on the incidence of constitutional chromosomal aberrations in patients with hematologic malignancies, but they could not confirm an increased risk for hematologic malignancy among carriers of structural chromosomal changes. However, it is of particular interest that constitutional structural aberrations with breakpoints similar to leukemia-associated specific breakpoints have been reported in patients with hematologic malignancies. Because of insufficient data, it remains still unclear if these aberrations represent random events or are associated with malignancy. There has been a substantial discussion about mechanisms involved in constitutional structural chromosomal changes in the literature. The documentation of more patients with constitutional structural chromosomal changes could be of major importance. Most importantly, the molecular investigation of chromosomal regions involved in rearrangements could give useful information on the genetic events underlying constitutional anomalies, contributing to isolation of genes important in the development of the neoplastic process. Regarding constitutional anomalies in patients with hematologic disorders, a survey of the cytogenetic data of our cytogenetics unit is herein also presented.
Panani
Anna D
AD
Critical Care Department, Medical School of Athens University, Epsilonvangelismos Hospital, Ipsilandou 45-47, Athens 106 76, Greece. apanani@med.uoa.gr
D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D019337:Hematologic Neoplasms / Q000209:etiology / Q000235:genetics*; D006801:Humans; D015994:Incidence