Palladium-catalyzed substitution of allylic fluorides.
As unusual substrates for the Tsuji-Trost allylation reaction, allylic fluorides are responsive to palladium-catalyzed substitution. Their activity towards this reaction fits in the series OCO(2)Me>OBz>>F>>OAc. The classic stereoretention mechanism that involves sequential inversions does not operate in this case. Several distinct cases are considered.
Hazari
Amaruka
A
Chemistry Research Laboratory, Oxford University, 12 Mansfield Rd., Oxford OX1 3TA, UK.
Gouverneur
Véronique
V
Brown
John M
JM