Concurrent smoking-related interstitial lung diseases in a single patient.
The three smoking-related interstitial lung diseases (ILD) include desquamative interstitial pneumonia (DIP), respiratory bronchiolitis-associated interstitial lung disease (RB-ILD), and pulmonary Langerhans cell histiocytosis (PLCH). They are considered discrete entities, yet it is not unusual to find a mixture of pathologic features rendering the histopathologic diagnosis difficult. It is uncommon to have overlap in the different radiologic findings between these diseases. We present a unique case, in that the extent of DIP and PLCH-like changes were manifested both histologically and on high resolution computed tomography (HRCT) with ground-glass attenuation and upper lobe cystic changes suggestive of both diseases.
Altayeh
Abdullah
A
Departments of Pulmonary/Critical Care and Pathology & Laboratory Medicine Services, Veterans Affairs Medical Center, Huntington, WV 25701, USA. abdullahaltayeh@yahoo.com
Alkhankan
Fadi
F
Triest
William
W
Badin
Shadi
S
D001706:Biopsy; D004452:Echocardiography; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007150:Immunohistochemistry; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
D005938:Glucocorticoids; D011241:Prednisone