title: Burkholderia pseudomallei: animal models of infection.
abstract: A range of animal models of Burkholderia pseudomallei infection have been reported, and the host species differ widely both in their susceptibility to infection and in the pathogenesis of disease. In mice, and depending on the route of infection, dose, and mouse strain, the disease can range from a chronic, and in some cases, an apparently latent infection to an acute fulminant disease. Alternative small animal models of infection include diabetic rats or hamsters. Larger animal models of disease have not yet been fully developed. It is not clear which of the small animal models of melioidosis most accurately reflect disease in humans. However, the findings that diabetic rats are susceptible to infection, that some strains of mice can develop persistent subclinical infections that can spontaneously reactivate, and that inhalation exposure generally results in more acute disease suggest that these different models mimic different aspects of human melioidosis.
authors.affiliation: School of Biosciences, Geoffrey Pope Building, University of Exeter, Exeter EX4 4QD, UK. r.w.titball@exeter.ac.uk
authors.forename: Richard W
authors.initials: RW
authors.lastname: Titball
authors.forename: Paul
authors.initials: P
authors.lastname: Russell
authors.forename: Jon
authors.initials: J
authors.lastname: Cuccui
authors.forename: Anna
authors.initials: A
authors.lastname: Easton
authors.forename: Ashraful
authors.initials: A
authors.lastname: Haque
authors.forename: Tim
authors.initials: T
authors.lastname: Atkins
authors.forename: Mitali
authors.initials: M
authors.lastname: Sarkar-Tyson
authors.forename: Vicki
authors.initials: V
authors.lastname: Harley
authors.forename: Brendan
authors.initials: B
authors.lastname: Wren
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Bancroft
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines; D016957:Burkholderia pseudomallei / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D006224:Cricetinae; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D006041:Goats; D006801:Humans; D008554:Melioidosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D011323:Primates; D051381:Rats; D055502:Secondary Prevention; D013045:Species Specificity; D014774:Virulence / Q000235:genetics
chemical_list: D001428:Bacterial Vaccines