[Dentistry anomalies in patients with Lynch syndrome and familial adenomatous polyposis].
OBJECTIVE
The aim of the study was evaluation of kind and frequency of dental anomalies in patients with familial adenomatous polyposis (FAP) and Lynch syndrome (HNPCC), and analysis of dento-osseus abnormalities on panoramic views.


METHODS
FAP group consisted of 15 patients with mutation of APC gene, HNPCC group consisted of 30 patients with mutation of MSH2 or MLH1 genes. Control groups consisted of 15 and 30 patients matched by a ratio of 1:1 in relation with age and sex. Examination included: history, physical examination (extra- and intraoral) and assessment of panoramic view. DMF index, OHI-S index, clinical and radiologic PI index, occlusion and presence of pathologic dental abrasion and parafunctions were assessed in intraoral examination.


RESULTS
The results are presented in figures and tables.


CONCLUSIONS
1. The kind and frequency of dental anomalies is comparable with changes typical to Polish population. 2. Osseus changes like osteomas, DBI's, hazy sclerosis and dental changes like supernumerary and impacted teeth are typical for patients with FAP. The frequency and appearance of this changes is higher than in general population. 3. Knowledge of kind and frequency of dental abnormalities may help in diagnosis and prevention of hereditary colon cancer by dentists.
Budzyńska
Agata
A
Katedra i Zakład Ortodoncji Pomorskiej Akademii Medycznej w Szczecinie al. Powstańców Wlkp. 72, 70-111 Szczecin.
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics; D011125:Adenomatous Polyposis Coli / Q000150:complications* / Q000235:genetics; D025601:Adenomatous Polyposis Coli Protein / Q000235:genetics; D000328:Adult; D000368:Aged; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000453:epidemiology* / Q000235:genetics; D015897:Comorbidity; D004245:DMF Index; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D011044:Poland / Q000453:epidemiology; D014071:Tooth Abnormalities / Q000453:epidemiology*
D048868:Adaptor Proteins, Signal Transducing; D025601:Adenomatous Polyposis Coli Protein; C501486:MLH1 protein, human; D009687:Nuclear Proteins; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein