title: Autism profiles of males with fragile X syndrome.
abstract: Autism, which is common in individuals with fragile X syndrome, is often difficult to diagnose. We compared the diagnostic classifications of two measures for autism diagnosis, the ADOS and the ADI-R, in addition to the DSM-IV-TR in 63 males with this syndrome. Overall, 30% of the subjects met criteria for autistic disorder and 30% met criteria for PDD-NOS. The classifications on the ADOS and DSM-IV-TR were most similar, whereas the ADI-R classified subjects as autistic much more frequently. We further investigated the relationship of both FMRP and FMRI mRNA to symptoms of autism in this cohort and found no significant relationship between the measures of autism and molecular features, including FMRP, FMRI mRNA, and CGG repeat number.
authors.affiliation: M.I.N.D. Institute and Department of Pediatrics, University of California at Davis Medical Center, Sacramento, CA 95817, USA. randi.hagerman@ucdmc.ucdavis.edu
authors.forename: Susan W
authors.initials: SW
authors.lastname: Harris
authors.forename: David
authors.initials: D
authors.lastname: Hessl
authors.forename: Beth
authors.initials: B
authors.lastname: Goodlin-Jones
authors.forename: Jessica
authors.initials: J
authors.lastname: Ferranti
authors.forename: Susan
authors.initials: S
authors.lastname: Bacalman
authors.forename: Ingrid
authors.initials: I
authors.lastname: Barbato
authors.forename: Flora
authors.initials: F
authors.lastname: Tassone
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Hagerman
authors.forename: Herman
authors.initials: H
authors.lastname: Herman
authors.forename: Randi J
authors.initials: RJ
authors.lastname: Hagerman
mesh_terms: D000223:Adaptation, Psychological; D000483:Alleles; D001321:Autistic Disorder / Q000150:complications* / Q000175:diagnosis*; D003072:Cognition Disorders / Q000150:complications / Q000175:diagnosis; D039721:Diagnostic and Statistical Manual of Mental Disorders; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics; D005600:Fragile X Syndrome / Q000150:complications* / Q000235:genetics*; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D055815:Young Adult
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human