title: Lymphomatoid granulomatosis of the uterine cervix.
abstract: Lymphomatoid granulomatosis is an Epstein-Barr virus-driven lymphoproliferative disorder, usually with a prominent pulmonary involvement and occasional extrapulmonary manifestations. Here, we present a case of lymphomatoid granulomatosis confined to the uterine cervix at the initial diagnosis. The disease was preceded by an immunosuppressive condition, namely low-grade lymphoplasmacytic lymphoma treated with chemotherapy. This is the first report of lymphomatoid granulomatosis at this site and emphasizes that it can present at unusual sites, such as the female genital tract in immunosuppressed patients.
authors.affiliation: Department of Histopathology, Level 9, Bristol Royal Infirmary, Marlborough Street, Bristol BS28HW, UK. eghbor@excite.com
authors.forename: Zsombor
authors.initials: Z
authors.lastname: Melegh
authors.forename: Judit
authors.initials: J
authors.lastname: Sutak
authors.forename: Alastair
authors.initials: A
authors.lastname: Whiteway
authors.forename: Nicholas
authors.initials: N
authors.lastname: Rooney
authors.forename: Joya
authors.initials: J
authors.lastname: Pawade
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008230:Lymphomatoid Granulomatosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000276:immunology* / Q000473:pathology; D014066:Palatine Tonsil / Q000378:metabolism / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; C106732:Epstein-Barr virus encoded RNA 2; D012367:RNA, Viral