title: Probabilistic finite element analysis of radiofrequency liver ablation using the unscented transform.
abstract: The main limitation of radiofrequency (RF) ablation numerical simulations reported in the literature is their failure to provide statistical results based on the statistical variability of tissue thermal-electrical parameters. This work developed an efficient probabilistic approach to hepatic RF ablation in order to statistically evaluate the effect of four thermal-electrical properties of liver tissue on the uncertainty of the ablation zone dimensions: thermal conductivity, specific heat, blood perfusion and electrical conductivity. A deterministic thermal-electrical finite element model of a monopolar electrode inserted in the liver was coupled with the unscented transform method in order to obtain coagulation zone confidence intervals, probability and cumulative density functions. The coagulation zone volume, diameter and length were 10.96 cm(3), 2.17 cm and 4.08 cm, respectively (P < 0.01). Furthermore, a probabilistic sensitivity analysis showed that perfusion and thermal conductivity account for >95% of the variability in coagulation zone volume, diameter and length.
authors.affiliation: Department of Electrical Engineering, University of Brasilia, Brasilia, DF 70910-900, Brazil. icaro@ieee.org
authors.forename: Icaro
authors.initials: I
authors.lastname: Dos Santos
authors.forename: Dieter
authors.initials: D
authors.lastname: Haemmerich
authors.forename: David
authors.initials: D
authors.lastname: Schutt
authors.forename: Adson Ferreira
authors.initials: AF
authors.lastname: da Rocha
authors.forename: Leonardo Rax
authors.initials: LR
authors.lastname: Menezes
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D020342:Finite Element Analysis; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008099:Liver / Q000503:physiopathology* / Q000601:surgery*; D008954:Models, Biological; D015233:Models, Statistical; D025321:Surgery, Computer-Assisted / Q000379:methods*