Sleep deprivation increases oleoylethanolamide in human cerebrospinal fluid.
This study investigated the role of two fatty acid ethanolamides, the endogenous cannabinoid anandamide and its structural analog oleoylethanolamide in sleep deprivation of human volunteers. Serum and cerebrospinal fluid (CSF) samples were obtained from 20 healthy volunteers before and after a night of sleep deprivation with an interval of about 12 months. We found increased levels of oleoylethanolamide in CSF (P = 0.011) but not in serum (P = 0.068) after 24 h of sleep deprivation. Oleoylethanolamide is an endogenous lipid messenger that is released after neural injury and activates peroxisome proliferator-activated receptor-alpha (PPAR-alpha) with nanomolar potency. Exogenous PPAR-alpha agonists, such as hypolipidemic fibrates and oleoylethanolamide, exert both neuroprotective and neurotrophic effects. Thus, our results suggest that oleoylethanolamide release may represent an endogenous neuroprotective signal during sleep deprivation.
Koethe
Dagmar
D
Department of Psychiatry and Psychotherapy, University of Cologne, 50924, Cologne, Germany.
Schreiber
Daniela
D
Giuffrida
Andrea
A
Mauss
Christian
C
Faulhaber
Johannes
J
Heydenreich
Bernd
B
Hellmich
Martin
M
Graf
Rudolf
R
Klosterkötter
Joachim
J
Piomelli
Daniele
D
Leweke
F Markus
FM
D000328:Adult; D001095:Arachidonic Acids / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism; D063385:Cannabinoid Receptor Modulators / Q000134:cerebrospinal fluid; D002851:Chromatography, High Pressure Liquid; D063388:Endocannabinoids; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000378:metabolism*; D009829:Oleic Acids / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism; D047493:PPAR alpha / Q000819:agonists / Q000378:metabolism*; D053284:Polyunsaturated Alkamides / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism; D012892:Sleep Deprivation / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D055815:Young Adult
D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D018696:Neuroprotective Agents; D009829:Oleic Acids; D047493:PPAR alpha; D053284:Polyunsaturated Alkamides; C488250:oleoylethanolamide; C078814:anandamide