Hydrophilic modifications of an amphiphilic polynorbornene and the effects on its hemolytic and antibacterial activity.
Here we report the modification of an amphiphilic antibacterial polynorbornene, Poly3, via incorporation of hydrophilic, biocompatible groups. The sugar, zwitterionic, and polyethylene glycol based moieties were incorporated in varying ratios by copolymerization and postpolymerization techniques. Well-defined copolymers with molecular weights of 3 kDa and narrow polydispersity indices ranging from 1.08 to 1.15 were obtained. The effects of these modifications on the biological activity of these polymers were analyzed by determining their minimum inhibitory concentrations (MIC) and their hemolytic activities (HC50).
Colak
Semra
S
Department of Polymer Science and Engineering, University of Massachusetts-Amherst, 120 Governors Drive, Amherst, Massachusetts 01003, USA.
Nelson
Christopher F
CF
Nüsslein
Klaus
K
Tew
Gregory N
GN
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects; D001672:Biocompatible Materials / Q000737:chemistry; D002241:Carbohydrates; D006461:Hemolysis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010969:Plastics / Q000737:chemistry / Q000494:pharmacology*; D020959:Polyethylene; D055672:Static Electricity
D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D002241:Carbohydrates; D010969:Plastics; C071464:polynorbornen; D020959:Polyethylene