title: [Correlations between the expression of vascular cell adhesion molecule-1 gene and clinical pathological characteristics and angiogenesis in oral squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the correlations between the expression of vascular cell adhesion molecule-1 (VCAM-1) gene and clinicopathologic characteristics and microvessel density (MVD) in oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  Expression and location of VCAM-1mRNA and protein in 48 OSCCs and 10 normal controls were detected by in situ hybridization and immunohistochemical stainingìMVD was also assessed. Statistical analysis was performed using SPSS13.0 software package for Student's t test and Chi-square test.
  
  
  RESULTS
  VCAM-1mRNA was mainly detected in cytoplasm of OSCC.VCAM-1 protein was mainly detected in membrane and cytoplasm of OSCC. The expression of VCAM-1mRNA and protein were significantly higher in OSCC tissues than normal oral tissues (P<0.01). In the clinicopathologic factors, lymph node metastasis and depth of infiltration were closely correlated with VCAM-1 expression (P<0.01), but there was no significant correlation between the positively expression and patients' sex, age and tumor' differentiated degree (P>0.05).
  
  
  CONCLUSIONS
  Overexpression of VCAM-1 gene in OSCC may play a potential role in the development of OSCC.It is closely associated with lymph node metastasis and the angiogenesis.
authors.affiliation: Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Binzhou Medical College, Binzhou 256603,Shangdong, China. sunlegang@163.com
authors.forename: Le-gang
authors.initials: LG
authors.lastname: Sun
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Song
authors.forename: Ling
authors.initials: L
authors.lastname: Liu
authors.forename: You-cheng
authors.initials: YC
authors.lastname: Yang
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Li-fang
authors.initials: LF
authors.lastname: Wang
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
chemical_list: D019010:Vascular Cell Adhesion Molecule-1