Serotoninergic system in the development of pyloric stenosis and pancreatitis.
Pyloric stenosis and pancreatitis were simulated before and after administration of serotonin and spiperone (5-HT2 receptor blocker). Activation of the serotoninergic system prevented the development of pancreatitis, but led to more severe course of pyloric stenosis.
Lychkova
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Institute of Gastroenterology, Moscow, Russia. lychkova@mail.ru
D000818:Animals; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D011707:Pyloric Stenosis / Q000473:pathology / Q000503:physiopathology*; D011708:Pylorus / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000494:pharmacology* / Q000502:physiology*; D058830:Serotonin 5-HT2 Receptor Antagonists; D018490:Serotonin Agents / Q000494:pharmacology; D013134:Spiperone / Q000494:pharmacology*; D014302:Trinitrobenzenesulfonic Acid / Q000633:toxicity
D058830:Serotonin 5-HT2 Receptor Antagonists; D018490:Serotonin Agents; D012701:Serotonin; D013134:Spiperone; D014302:Trinitrobenzenesulfonic Acid