Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice.
OBJECTIVE
The aim of this study is to determine the effect of coenzyme Q (Q) on ob/ob mice treated or not with thiazolidinedione (TZD).


METHODS
Ob/ob mice were treated with Q, Rosiglitazone or a combination of both molecules for 13 days; physical and metabolic parameters as well as oral glucose tolerance test were assessed. mRNA expression of genes of energy dissipation and storage were measured by real-time PCR.


RESULTS
Q treatment improved some metabolic parameters in ob/ob mice. Surprisingly, cotreatment with Rosiglitazone and Q improved metabolic parameters and prevented TZD increase in body weight and adiposity, mainly by increasing lipid oxidation in adipose tissue, reducing lipid synthesis and balancing adipokine gene expression.


CONCLUSIONS
Our finding suggests that Rosiglitazone and coenzyme Q bitherapy could prevent the body weight gain associated with adipogenesis and could improve the clinical use of these compounds.
Carmona
M C
MC
UMR 5241 UPS-CNRS, IFR109, CHU Rangueil, Toulouse Cedex, France.
Lefebvre
P
P
Lefebvre
B
B
Galinier
A
A
Benani
A
A
Jeanson
Y
Y
Louche
K
K
Flajollet
S
S
Ktorza
A
A
Dacquet
C
C
Pénicaud
L
L
Casteilla
L
L
D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D000818:Animals; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects / Q000235:genetics; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000494:pharmacology*; D014451:Ubiquinone / Q000008:administration & dosage / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics
D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D014451:Ubiquinone