Biological activity of anomeric pairs of lipophilic glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine.
We studied the capacity of anomeric pairs of alpha- and beta-dodecyl, alpha- and beta-(1-pentylhexyl), and alpha- and beta-cyclododecyl glycosides of N-acetylmuramyl-L-alanyl-D-isoglutamine (muramyl dipeptide) to stimulate the nonspecific resistance of mice to intraperitoneal infection of Staphylococcus aureus and Escherichia coli cultures. Intraperitoneal pretreatment with the test substances in a wide dose range increased survival of infected animals. No differences were found between the biological effects of alpha- and beta-dodecyl and alpha- and beta-(1-pentylhexyl) glycosides of muramyl dipeptide. An inverse relationship was found between stimulatory activity and dose of alpha- and beta-cyclododecyl glycosides of muramyl dipeptide during sepsis caused by Staphylococcus aureus.
Kalyuzhin
O V
OV
Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. kalyuzhin@list.ru
Zemlyakov
A E
AE
Kalina
N G
NG
Mulik
E L
EL
Kuzovlev
F N
FN
Makarova
O V
OV
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000276:immunology; D006027:Glycosides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D018805:Sepsis / Q000188:drug therapy / Q000276:immunology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000276:immunology; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D006027:Glycosides; D000119:Acetylmuramyl-Alanyl-Isoglutamine