title: Synthesis of substituted 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones.
abstract: We have developed a liquid-phase route for combinatorial synthesis of novel substituted 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones. Biginelli-type three-component condensation of 1-(3-aryl-1,2,4-oxadiazol-5-yl)acetones, thiourea, and benzaldehydes is shown to result in new 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thione heterocyclic system. If salicylaldehydes are used in this reaction, a mixture of 5-(1,2,4-oxadiazol-5-yl)-3,4-dihydropyrimidine-2(1H)-thiones and 11-(1,2,4-oxadiazol-5-yl)-2,3,5,6-tetrahydro-4H-2,6-methano-1,3,5-benzoxadiazocine-4-thiones is formed.
authors.affiliation: Chemical Department, V.N. Karazin Kharkiv National University, 4 Svoboda Sq., Kharkiv 61077, Ukraine.
authors.forename: Juliya V
authors.initials: JV
authors.lastname: Kharchenko
authors.forename: Oleksandr S
authors.initials: OS
authors.lastname: Detistov
authors.forename: Valeriy D
authors.initials: VD
authors.lastname: Orlov
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015394:Molecular Structure; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010069:Oxadiazoles; D011743:Pyrimidines; D013871:Thiones