Lymphomatoid granulomatosis of the uterine cervix.
Lymphomatoid granulomatosis is an Epstein-Barr virus-driven lymphoproliferative disorder, usually with a prominent pulmonary involvement and occasional extrapulmonary manifestations. Here, we present a case of lymphomatoid granulomatosis confined to the uterine cervix at the initial diagnosis. The disease was preceded by an immunosuppressive condition, namely low-grade lymphoplasmacytic lymphoma treated with chemotherapy. This is the first report of lymphomatoid granulomatosis at this site and emphasizes that it can present at unusual sites, such as the female genital tract in immunosuppressed patients.
Melegh
Zsombor
Z
Department of Histopathology, Level 9, Bristol Royal Infirmary, Marlborough Street, Bristol BS28HW, UK. eghbor@excite.com
Sutak
Judit
J
Whiteway
Alastair
A
Rooney
Nicholas
N
Pawade
Joya
J
D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008230:Lymphomatoid Granulomatosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000276:immunology* / Q000473:pathology; D014066:Palatine Tonsil / Q000378:metabolism / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy / Q000473:pathology
D000970:Antineoplastic Agents; C106732:Epstein-Barr virus encoded RNA 2; D012367:RNA, Viral