title: Intralesional injection of Pingyangmycin may be an effective treatment for epulis.
abstract: Gingival epulis represents a family of benign tumors and tumorlike masses of the gingiva. A spectrum of inflammatory and other reactive changes can be observed pathologically as granulation, fibrous or vascular tissue. It may occur at any age, but most commonly found in patients at their twenties and sixties. Women are more frequently affected than men. Surgical excision or removal is the treatment of choice, and wider resection including extraction of the involved teeth and adjacent tissues is often required in order to prevent recurrence. However, wider resection may result in cosmetic and functional problems. Epulis bears some similarities with hemangioma both clinically and histopathologically. Therefore, we hypothesize that intralesional injection of Pingyangmycin may be a safe and effective treatment for epulis. The efficacy of this treatment modality is worthy of further investigation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China.
authors.forename: Jia Wei
authors.initials: JW
authors.lastname: Zheng
authors.forename: Qin
authors.initials: Q
authors.lastname: Zhou
authors.forename: Xiu Juan
authors.initials: XJ
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: He
authors.forename: Yan An
authors.initials: YA
authors.lastname: Wang
authors.forename: Wei Min
authors.initials: WM
authors.lastname: Ye
authors.forename: Han Guang
authors.initials: HG
authors.lastname: Zhu
authors.forename: Zhi Yuan
authors.initials: ZY
authors.lastname: Zhang
mesh_terms: D001761:Bleomycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D005887:Gingival Neoplasms / Q000188:drug therapy*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male
chemical_list: D001761:Bleomycin; C025703:bleomycetin