title: Plug-based microfluidics with defined surface chemistry to miniaturize and control aggregation of amyloidogenic peptides.
abstract: Small with control: For miniaturization of protein aggregation experiments the interfacial chemistry must be controlled to avoid protein aggregation caused by interfacial adsorption. Plug-based microfluidics with defined surface chemistry (see schematic picture) can then be used to perform hundreds of aggregation experiments with volume-limited samples, such as cerebrospinal fluid from mice.
authors.affiliation: Department of Chemistry, University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.
authors.forename: Matthias
authors.initials: M
authors.lastname: Meier
authors.forename: Julia
authors.initials: J
authors.lastname: Kennedy-Darling
authors.forename: Se Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Eric M
authors.initials: EM
authors.lastname: Norstrom
authors.forename: Sangram S
authors.initials: SS
authors.lastname: Sisodia
authors.forename: Rustem F
authors.initials: RF
authors.lastname: Ismagilov
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid; D000682:Amyloid / Q000737:chemistry*; D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D044085:Microfluidics / Q000379:methods*; D008904:Miniaturization; D010455:Peptides / Q000737:chemistry*; D018401:Sample Size; D013499:Surface Properties
chemical_list: D000682:Amyloid; D010455:Peptides