title: Synthesis of a potent G-quadruplex-binding macrocyclic heptaoxazole.
abstract: A novel G-quadruplex binder, L1H1-7OTD (shown in color by atom type), was developed. This macrocyclic heptaoxazole potently and selectively stabilizes telomeric DNA in an intramolecular antiparallel G-quadruplex conformation. L1H1-7OTD shows selective cytotoxicity toward HeLa cells, a telomerase-positive cell line.
authors.affiliation: Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, Koganei, Tokyo, Japan.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tera
authors.forename: Keisuke
authors.initials: K
authors.lastname: Iida
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Ishizuka
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Masami
authors.initials: M
authors.lastname: Suganuma
authors.forename: Takayuki
authors.initials: T
authors.lastname: Doi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagasawa
mesh_terms: D000818:Animals; D002460:Cell Line; D054856:G-Quadruplexes; D006801:Humans; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D016615:Telomere / Q000737:chemistry / Q000235:genetics
chemical_list: D047028:Macrocyclic Compounds; D010080:Oxazoles