Probing the lactose.GM3 carbohydrate-carbohydrate interaction with glycodendrimers.
Multivalent glycoconjugates were prepared using generation-4 PAMAM dendrimers, and their interaction with Langmuir monolayers containing GM3 was investigated. Excessive carbohydrate valency adversely affects the carbohydrate-carbohydrate interaction. The GM3 monolayer selectively interacts with lactose-functionalized dendrimers in the presence of calcium ions.
Seah
Nicole
N
Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
Santacroce
Paul V
PV
Basu
Amit
A
D002241:Carbohydrates / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D005679:G(M3) Ganglioside / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D007785:Lactose / Q000737:chemistry*; D015394:Molecular Structure
D002241:Carbohydrates; D050091:Dendrimers; D005679:G(M3) Ganglioside; D006001:Glycoconjugates; D007785:Lactose