title: PPAR-delta in Vascular Pathophysiology.
abstract: Peroxisome proliferator-activated receptors belong to the superfamily of ligand-dependent nuclear receptor transcription factors, which include three subtypes: PPAR-alpha, beta/delta, and gamma. PPAR-delta, play important roles in the regulation of cell growth and differentiation as well as tissue wound and repair. Emerging evidence has also demonstrated that PPAR-delta is implicated in lipids and glucose metabolism. Most recently, the direct effects of PPAR-delta on cardiovascular processes such as endothelial function and angiogenesis have also been investigated. Therefore, it is suggested that PPAR-delta may have critical roles in cardiovascular pathophysiology and is a potential target for therapeutic intervention of cardiovascular disorders such as atherosclerosis.
authors.affiliation: Laboratory of Vascular Molecular Biology and Bioengineering, Institute of Cardiovascular Science and Diabetes Center, Peking University Health Science Center, Beijing 100191, China.
authors.forename: Nanping
authors.initials: N
authors.lastname: Wang