Conductive single-walled carbon nanotube substrates modulate neuronal growth.
We used conductive nanotube films as substrates with which we could systematically vary the conductance to see how this property affects neuronal growth. Here we show that nanotube substrates in a narrow range of conductivity promote the outgrowth of neurites with a decrease in the number of growth cones as well as an increase in cell body area, while at higher conductance these effects disappear.
Malarkey
Erik B
EB
Department of Neurobiology, Center for Glial Biology in Medicine, Atomic Force Microscopy & Nanotechnology Laboratories, Civitan International Research Center, Evelyn F. McKnight Brain Institute, University of Alabama, Birmingham, Alabama 35294, USA.
Fisher
Kirk A
KA
Bekyarova
Elena
E
Liu
Wei
W
Haddon
Robert C
RC
Parpura
Vladimir
V
D000818:Animals; D000831:Animals, Newborn; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004553:Electric Conductivity; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure*; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D037742:Nanotubes, Carbon