title: Validation of an echocardiographic multiparametric strategy to increase responders patients after cardiac resynchronization: a multicentre study.
abstract: OBJECTIVE
  We sought to develop and validate a multiparametric algorithm by applying previously validated criteria to predict cardiac resynchronization therapy (CRT) response in a multicentre study. Thirty per cent of patients treated by CRT fail to respond to the treatment. Although dyssynchrony by echocardiography has been used to improve the selection of patients, the complexity of myocardial contraction has generated a moderate improvement using any of several individual parameters.
  
  
  RESULTS
  Two hundred end-stage heart failure patients [NYHA 3-4 and left ventricular ejection fraction (LVEF)<35%] with QRS>120 ms were included. Echocardiography analysis focused on the following parameters: atrioventricular dyssynchrony, interventricular dyssynchrony, and intraventricular dyssynchrony that integrated radial (PSAX M-mode) and longitudinal [tissue Doppler imaging (TDI)] evaluations for spatial (wall to wall) and temporal (wall end-systole to mitral valve opening) dyssynchrony diagnosis. Following CRT implantation, patients were monitored for 6 months with functional and echo evaluations defining responders by a 15% reduction in end-systolic volume. Mean QRS duration and LVEF were 152 +/- 17 ms and 25 +/- 8%. There was a CRT response in 57% of patients, independent of QRS width. Mean prevalence of positive criteria was 34 +/- 8%. Feasibility and variability averages were 81 +/- 20% and 9 +/- 4%. In a single parametric approach, ranges of sensitivities and specificities were 18-65% and 45-84% with a mean of 41% and 66%. A multiparametric approach by focusing on criteria combination decreased the mean rate of false-positive results to 14 +/- 12%, 5 +/- 4%, 2 +/- 2%, and 1 +/- 2% from one to four parameters, respectively. More than three parameters were associated with a specificity above 90% and a positive predictive value above 65%. Reproducibility of this global strategy was 91%.
  
  
  CONCLUSIONS
  A multiparametric echocardiographic strategy based on the association of conventional criteria is a better indicator of CRT response than the existing single parametric approaches.
authors.affiliation: Cardiologic Hospital & Inserm 828, Bordeaux University Hospital Centre, Bordeaux, France. stephane.lafitte@chu-bordeaux.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Lafitte
authors.forename: Patricia
authors.initials: P
authors.lastname: Reant
authors.forename: Amira
authors.initials: A
authors.lastname: Zaroui
authors.forename: Erwan
authors.initials: E
authors.lastname: Donal
authors.forename: Aude
authors.initials: A
authors.lastname: Mignot
authors.forename: Hannan
authors.initials: H
authors.lastname: Bougted
authors.forename: Hasnaa
authors.initials: H
authors.lastname: Belghiti
authors.forename: Pierre
authors.initials: P
authors.lastname: Bordachar
authors.forename: Antoine
authors.initials: A
authors.lastname: Deplagne
authors.forename: Julie
authors.initials: J
authors.lastname: Chabaneix
authors.forename: Frédéric
authors.initials: F
authors.lastname: Franceschi
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Deharo
authors.forename: Pierre
authors.initials: P
authors.lastname: Dos Santos
authors.forename: Jacques
authors.initials: J
authors.lastname: Clementy
authors.forename: Raymond
authors.initials: R
authors.lastname: Roudaut
authors.forename: Christophe
authors.initials: C
authors.lastname: Leclercq
authors.forename: Gilbert
authors.initials: G
authors.lastname: Habib
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D002304:Cardiac Pacing, Artificial; D004812:Epidemiologic Methods; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000628:therapy*