title: Genetic analysis of canine parvovirus type 2c.
abstract: The sequence of the full-length gene encoding for the main capsid protein VP2 of 58 canine parvovirus (CPV) type 2c strains, along with recent CPV-2a/2b strains, was determined and analysed in comparison with reference CPV isolates. The CPV-2c strains displayed a low genetic variability and shared amino acid changes already detected in recent CPV-2a/2b isolates, with a phylogenetic clustering accounting for their geographical distribution. Analysis of the selection pressure driving CPV evolution confirmed that the VP2 gene is under purifying selection. The emergence and global spread of the new CPV variant provides an interesting model to better understand virus evolution.
authors.affiliation: Department of Public Health and Animal Sciences, Valenzano, Bari, Italy. n.decaro@veterinaria.uniba.it
authors.forename: Nicola
authors.initials: N
authors.lastname: Decaro
authors.forename: Costantina
authors.initials: C
authors.lastname: Desario
authors.forename: Antonio
authors.initials: A
authors.lastname: Parisi
authors.forename: Vito
authors.initials: V
authors.lastname: Martella
authors.forename: Alessio
authors.initials: A
authors.lastname: Lorusso
authors.forename: Angela
authors.initials: A
authors.lastname: Miccolupo
authors.forename: Viviana
authors.initials: V
authors.lastname: Mari
authors.forename: Maria Loredana
authors.initials: ML
authors.lastname: Colaianni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cavalli
authors.forename: Livia
authors.initials: L
authors.lastname: Di Trani
authors.forename: Canio
authors.initials: C
authors.lastname: Buonavoglia
mesh_terms: D000818:Animals; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics*; D004283:Dog Diseases / Q000821:virology*; D004285:Dogs; D014644:Genetic Variation; D008969:Molecular Sequence Data; D010322:Parvoviridae Infections / Q000235:genetics / Q000662:veterinary* / Q000821:virology; D017993:Parvovirus, Canine / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification*; D010802:Phylogeny
chemical_list: D036022:Capsid Proteins