title: Performance of selected nonparametric tests for discrete longitudinal data under different patterns of missing data.
abstract: Comparison of changes over time of a continuous response variable between treatment groups is often of main interest in clinical trials. When the distributional properties of the continuous response variable are not regular enough, or when the response is discrete, nonparametric techniques have been used. The relative performances of selected repeated measures nonparametric two-sample tests proposed by Wei and Lachin, Koziol, Wei and Johnson, and the adapted Wilcoxon Rank-Sum test are compared through simulations based on quality of life data. The Wilcoxon Rank-Sum test is the most powerful and is not significantly affected by the different patterns of missing data.
authors.affiliation: Applied Statistics and Epidemiology Research Group, Department of Mathematical Sciences, Chancellor College, Zomba, Malawi. tchirwa@chanco.unima.mw
authors.forename: T F
authors.initials: TF
authors.lastname: Chirwa
authors.forename: J
authors.initials: J
authors.lastname: Bogaerts
authors.forename: E D
authors.initials: ED
authors.lastname: Chirwa
authors.forename: L N
authors.initials: LN
authors.lastname: Kazembe
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D006801:Humans; D008137:Longitudinal Studies; D010349:Patient Compliance / Q000706:statistics & numerical data; D010352:Patient Dropouts / Q000706:statistics & numerical data; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D018709:Statistics, Nonparametric