title: Preliminary investigations on the synthesis and antitumor activity of 3(2H)-furanones.
abstract: Two triaryl-3(2H)-furanones were synthesized and their antitumor activity was evaluated. These compounds inhibited the proliferation of DLA cell line in vitro. In vivo studies also showed that these compounds were active against tumor cell proliferation.
authors.affiliation: Department of Applied Chemistry, Cochin University of Science and Technology, Kochi 682 022, Kerala, India.
authors.forename: J P
authors.initials: JP
authors.lastname: Rappai
authors.forename: V
authors.initials: V
authors.lastname: Raman
authors.forename: P A
authors.initials: PA
authors.lastname: Unnikrishnan
authors.forename: S
authors.initials: S
authors.lastname: Prathapan
authors.forename: S K
authors.initials: SK
authors.lastname: Thomas
authors.forename: C S
authors.initials: CS
authors.lastname: Paulose
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004247:DNA / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry*; D006801:Humans; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry; D013329:Structure-Activity Relationship; D020058:Styrene / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D020058:Styrene; D004247:DNA; D019342:Acetic Acid; D010100:Oxygen