The CCK(2) agonist BC-264 decreases predatory fear freezing at high but not low dosages in PVG hooded rats during initial exposure to a cat.
BC-264 a CCK(2) agonist reverses chronically developed habituated predatory fear freezing behavior in PVG hooded rats. However, the acute effects of BC264 have not been previously examined. The effects of BC-264 (0.1-30microg/kg) on the mean percentage of PVG hooded rat freezing during an initial first time 20min cat exposure were calculated. At higher doses (15 or 30microg/kg) but not lower doses (0.1-1microg/kg) BC264 statistically significantly decreased freezing compared to control (p<0.001).
McLachlan
Craig S
CS
Department of Pharmacology, National University of Singapore, Singapore. reperfusion@hotmail.com
Farook
Justin M
JM
Daugé
Valérie
V
Wong
Peter T
PT
D000818:Animals; D002415:Cats; D002766:Cholecystokinin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005239:Fear; D010446:Peptide Fragments / Q000494:pharmacology*; D011235:Predatory Behavior; D051381:Rats; D043887:Receptor, Cholecystokinin B / Q000819:agonists*
C084553:BC 264; D010446:Peptide Fragments; D043887:Receptor, Cholecystokinin B; D002766:Cholecystokinin