CHRFAM7A copy number and 2-bp deletion polymorphisms and antisaccade performance.
Chromosome 15q13-q14 harbours the gene for the alpha7 nicotinic acetylcholine receptor subunit (CHRNA7) and a related gene (CHRFAM7A) which arises from a partly duplicated portion of CHRNA7. Recent evidence suggests that CHRFAM7A is a locus with a possible role in schizophrenia and cognitive functioning. We studied an antisaccade task as a fronto-parietal measure of executive function that reflects risk for schizophrenia. Association of CHRFAM7A genotype with antisaccade performance was assessed in 103 healthy Caucasian individuals. No significant associations of 2-bp deletion or CHRFAM7A copy number with antisaccade performance parameters were observed. The failure to observe an association between antisaccade performance and polymorphisms in CHRFAM7A gene is consistent with specificity of the gene effects on hippocampal and memory functions as previously demonstrated.
Petrovsky
Nadine
N
Department of Psychiatry and Psychotherapy, University of Bonn, Germany. Nadine.Petrovsky@ukb.uni-bonn.de
Schmechtig
Anne
A
Flomen
Rachel H
RH
Kumari
Veena
V
Collier
David
D
Makoff
Andrew
A
Wagner
Michael
M
Ettinger
Ulrich
U
D000328:Adult; D000704:Analysis of Variance; D004585:Electrooculography / Q000379:methods; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010551:Personality / Q000235:genetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D011340:Problem Solving / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000235:genetics*; D012438:Saccades / Q000235:genetics*; D017384:Sequence Deletion / Q000235:genetics*; D011795:Surveys and Questionnaires; D055815:Young Adult; D064569:alpha7 Nicotinic Acetylcholine Receptor
C579167:Chrna7 protein, human; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor