[HLA-G alleles and risk of early pregnancy loss].
BACKGROUND
To investigate whether HLA-G gene polymorphism is associated with adverse pregnancy outcome, we screened exons 2, 3, 4 of HLA-G gene in 59 women with reproductive failure and 36 fertile women. The HLA-G 10108 allele was more common in the group of examined women than in women from the control group (OR = 5,9; p = 0,09), but this difference was not statistically significant.


RESULTS
We conclude that the HLA-G 10108 allele might influence pregnancy outcome in the Polish population, but further studies are needed in this regard.
Sipak-Szmigiel
Olimpia
O
Klinika Medycyny Matczyno-Płodowej Pomorskiej Akademii Medycznej w Szczecinie ul. Unii Lubelskiej 1, 72-252 Szczecin.
Cybulski
Cezary
C
Ronin-Walknowska
Elzbieta
E
Lubiński
Jan
J
D000022:Abortion, Spontaneous / Q000235:genetics*; D000328:Adult; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D011247:Pregnancy
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I