title: Direct comparison of logistic regression and recursive partitioning to predict chemotherapy response of breast cancer based on clinical pathological variables.
abstract: The purpose was to compare logistic regression model (LRM) and recursive partitioning (RP) to predict pathologic complete response to preoperative chemotherapy in patients with breast cancer. The two models were built in a same training set of 496 patients and validated in a same validation set of 337 patients. Model performance was quantified with respect to discrimination (evaluated by the areas under the receiver operating characteristics curves (AUC)) and calibration. In the training set, AUC were similar for LRM and RP models (0.77 (95% confidence interval, 0.74-0.80) and 0.75 (95% CI, 0.74-0.79), respectively) while LRM outperformed RP in the validation set (0.78 (95% CI, 0.74-0.82) versus 0.64 (95% CI, 0.60-0.67). LRM model also outperformed RP model in term of calibration. In these real datasets, LRM model outperformed RP model. It is therefore more suitable for clinical use.
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Tenon, Assistance Publique des Hôpitaux de Paris, Pierre et Marie Curie University - Paris 6, 4 rue de Chine, 75020, Paris Cedex, France. roman.rouzier@tnn.aphp.fr
authors.forename: Roman
authors.initials: R
authors.lastname: Rouzier
authors.forename: Charles
authors.initials: C
authors.lastname: Coutant
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Lesieur
authors.forename: Chafika
authors.initials: C
authors.lastname: Mazouni
authors.forename: Roberto
authors.initials: R
authors.lastname: Incitti
authors.forename: René
authors.initials: R
authors.lastname: Natowicz
authors.forename: Lajos
authors.initials: L
authors.lastname: Pusztai
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019540:Area Under Curve; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015233:Models, Statistical; D009367:Neoplasm Staging; D012372:ROC Curve; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents