Dissociated learning using GABAergic drugs.
Experiments on Wistar rats addressed the possibility of dissociated learning using drugs acting directly on brain GABA(B) receptors. A previously suggested hypothesis was tested: that the cholinergic system of the brain plays the decisive role in the mechanisms of dissociative learning. The data obtained here provided evidence that dissociated learning an occur with compounds acting on the GABAergic transmitter system of the brain. Dissociated states arose on treatment of animals with both the GABA-mimetic baclofen and the GABA receptor antagonist 5-aminovaleric acid. Thus, these results show that dissociated learning can occur using drugs acting on both the cholinergic and the GABAergic transmitter systems of the brain.
Azarashvili
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Laboratory for Biological System Energetics, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. azarashvili@rambler.ru
Kaimachnikova
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D021542:Amino Acids, Neutral / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D007858:Learning / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018080:Receptors, GABA-B / Q000502:physiology*
D021542:Amino Acids, Neutral; D058786:GABA-B Receptor Agonists; D058788:GABA-B Receptor Antagonists; D018080:Receptors, GABA-B; C013809:5-aminovaleric acid; D001418:Baclofen