Defatted bovine colostrum-supplemented diet around weaning improves exocrine pancreatic secretion by means of volume, digestive enzymes, and antibacterial activity.
OBJECTIVE
Exocrine pancreatic secretion contributes to limit pathogenic bacteria-associated diarrhea. Bovine colostrum, used in the treatment of diarrhea, reduces symptoms originating from gut pathogenic bacteria overgrowth. We hypothesized that bovine colostrum may stimulate the exocrine pancreatic secretion.


METHODS
Eighteen piglets fitted with 2 permanent catheters (for pancreatic juice collection and reintroduction) were allocated to 1 of the following 2 dietary treatments for 5 days: a control diet or a diet supplemented with defatted bovine colostrum. Pancreatic juice was collected daily, and digestive enzyme activities and antibacterial activity were determined.


RESULTS
The prandial pancreatic juice outflow, the basal and prandial lipase output, and the basal secretion of the antibacterial activity were, respectively, 60% (P = 0.08), 154% (P = 0.08), 92% (P = 0.06), and 72% (P < 0.05) higher in piglets fed a diet supplemented with defatted bovine colostrum.


CONCLUSIONS
With defatted bovine colostrum, the increased antibacterial activity secretion against Escherichia coli may limit pathogenic bacteria overgrowth of the gut and reduce diarrheal episodes. The role of secretin in the increased pancreatic juice flow and lipase secretion was considered.
Huguet
Antoine
A
INRA/Agrocampus Ouest, UMR 1079, Rennes, France.
Savary
Gérard
G
Bobillier
Eric
E
Le Huërou-Luron
Isabelle
I
D000681:Amylases / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D003126:Colostrum; D019587:Dietary Supplements; D008049:Lipase / Q000378:metabolism; D046790:Pancreas, Exocrine / Q000378:metabolism* / Q000502:physiology; D010189:Pancreatic Juice / Q000378:metabolism*; D013552:Swine; D014357:Trypsin / Q000378:metabolism; D014886:Weaning
D000900:Anti-Bacterial Agents; D008049:Lipase; D000681:Amylases; D014357:Trypsin