Physiological effects of complexes of angiotensins with functionally different carrier proteins.
We compared activity of synthetic complexes of angiotensin II and functionally different proteins (transport protein, serum albumin and neurospecific Ca2+-binding protein S100b) as analogues of endogenous protein-peptide complexes. Physiological activity of angiotensin II was specifically modified by these proteins. It was hypothesized that the complex of angiotensin II and S100b is primarily involved in the regulation of hemodynamics, whereas the complex of angiotensin II and bovine serum albumin plays a role in the formation and realization of drinking behavior.
Pevtsova
E I
EI
P. K. Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. lab_motiv@mail.ru
Tolpygo
S M
SM
Obukhova
M F
MF
Kotov
A V
AV
D000804:Angiotensin II / Q000008:administration & dosage / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002216:Captopril / Q000494:pharmacology; D002352:Carrier Proteins / Q000008:administration & dosage / Q000378:metabolism*; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009414:Nerve Growth Factors / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000008:administration & dosage / Q000378:metabolism*; D012504:Saralasin / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000378:metabolism*
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002352:Carrier Proteins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579158:S100b protein, rat; D000804:Angiotensin II; D012710:Serum Albumin, Bovine; D002216:Captopril; D012504:Saralasin