title: Oxidase-like activity of polymer-coated cerium oxide nanoparticles.
abstract: Inorganic enzyme? Ceria nanoparticles exhibit unique oxidase-like activity at acidic pH values. These redox catalysts can be used in immunoassays (ELISA) when modified with targeting ligands (see picture; light blue and yellow structures are nanoparticles with attached ligands). This modification allows both for binding and for detection by the catalytic oxidation of sensitive colorimetric dyes (e.g. TMB).
authors.affiliation: Nanoscience Technology Center, Department of Chemistry and Burnett College of Biomedical Sciences, University of Central Florida, 12424 Research Parkway, Suite 400, Orlando, FL 32826, USA.
authors.forename: Atul
authors.initials: A
authors.lastname: Asati
authors.forename: Santimukul
authors.initials: S
authors.lastname: Santra
authors.forename: Charalambos
authors.initials: C
authors.lastname: Kaittanis
authors.forename: Sudip
authors.initials: S
authors.lastname: Nath
authors.forename: J Manuel
authors.initials: JM
authors.lastname: Perez
mesh_terms: D002384:Catalysis; D045744:Cell Line, Tumor; D002563:Cerium / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011108:Polymers / Q000737:chemistry*
chemical_list: D005456:Fluorescent Dyes; D011108:Polymers; D002563:Cerium; C030583:ceric oxide; D010088:Oxidoreductases