title: Cardiac troponin-T in pre-end stage kidney disease.
abstract: BACKGROUND
  Cardiac troponin T level (cTnT) is commonly increased in end stage chronic kidney disease (CKD) in the absence of acute myocardial infarction. There are few data available on serum cTnT concentration in patients with pre-end stage CKD.
  
  
  OBJECTIVE
  To evaluate the correlation of cTnT level and severity of kidney disease in patients with CKD stage 3 and 4 and to evaluate whether there is a relationship between left ventricular mass index and cTnT level.
  
  
  METHODS
  Patients (103) with CKD stage 3-4 between 26 and 85 years of age (mean 60.0 +/- 11.9) entered the present study. Serum cTnT determined using a third-generation electrochemiluminescent immunoassay on an Elecsys 2010 analyzer (Roche Diagnostics Ltd.). All patients underwent echocardiography. Left ventricular hypertrophy (LVH) was considered when LV mass index exceeded 125 g/m2.
  
  
  RESULTS
  Overall, 28 patients (28.2%) had cTnT > 0.01 micro/L and two patients (1.8%) had cTnT > 0.1 microg/L cTnT concentration was commonly increased in more severe CKD (9 patients in stage 3 and 20 patients in stage 4). LVH was not associated with increased cTnT (p=0.105).
  
  
  CONCLUSIONS
  The present study demonstrated that the elevated cTnT > 0.01 microg/L is relatively common in patients with CKD stage 3-4 who do not require dialysis treatment, however serum cTnT level above > 0.1 microg/L is uncommon in this population. Increased serum cTnT is associated with decreased renal clearance but not LVH.
authors.affiliation: Division of Cardiology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. sonkia@kku.ac.th
authors.forename: Songsak
authors.initials: S
authors.lastname: Kiatchoosakun
authors.forename: Dujdao
authors.initials: D
authors.lastname: Sahasthas
authors.forename: Chaiyasith
authors.initials: C
authors.lastname: Wongvipaporn
authors.forename: Cholatip
authors.initials: C
authors.lastname: Pongskul
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013997:Time Factors; D020107:Troponin T / Q000097:blood*; D014463:Ultrasonography
chemical_list: D020107:Troponin T