[Effects of mercazolyl and L-thyroxine on the antiedematous activity of immunotropic preparations during development of toxic brain edema and swelling].
Dysfunction of thyroid gland plays an important role in the pathogenesis of brain edema and swelling. Toxic brain edema and swelling was modeled under condition of hypo- and hyperfunction of thyroid gland. Mercazolyl and L-thyroxine ambiguously influence the development of toxic brain edema and swelling in rats. L-thyroxin (35.7 microg/kg) favors increase in the water content in brain tissue, which can be considered as synergism with the edematous factor and the formation of brain tissue susceptibility to the development of brain edema and swelling. The administration of mercazolyl (5 mg/kg) and L-thyroxin (35.7 microg/kg) with thymogen (10 microg/kg), thymalin (1.2 mg/kg), cycloferon (0.5 mg/kg) results in decreasing brain tissue density as compared to intact animals. Dysfunction of the thyroid gland leads to changes in pharmacodynamics of immune preparations, which results in a decrease of their antiedematous activity.
Platonov
I A
IA
Anashchenkova
T A
TA
Andreeva
T A
TA
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D001929:Brain Edema / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D005260:Female; D007037:Hypothyroidism / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013963:Thyroid Hormones / Q000378:metabolism; D013971:Thyrotoxicosis / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D013963:Thyroid Hormones; D008713:Methimazole; D013974:Thyroxine