A measles-derived peptide treats and vaccinates against adjuvant arthritis.
Measles vaccine and porcine myelin basic protein were both found to ameliorate or abolish the symptoms of adjuvant arthritis (AA) in Lewis rats whether inoculated at the time of adjuvant administration or after the onset of arthritis. These results are consistent with clinical observations that measles infection can sometimes cause remission of juvenile rheumatoid arthritis. The fact that measles virus proteins and myelin basic protein have significant regions of homology allowed peptides based on these regions to be synthesized. A twenty-amino acid sequence exhibits significant anti-arthritic activity when inoculated into rats with pre-existing AA and it also prevented onset of AA when a single dose was preinoculated three weeks prior to AA induction. These data suggest the possibility of developing novel therapeutic vaccines against some forms of arthritis.
Root-Bernstein
Robert
R
Department of Physiology, Michigan State University, East Lansing, MI 48824, USA. rootbern@msu.edu
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D001172:Arthritis, Rheumatoid / Q000276:immunology; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006801:Humans; D016056:Immunodominant Epitopes / Q000008:administration & dosage / Q000737:chemistry; D007167:Immunotherapy; D035002:Lower Extremity / Q000473:pathology; D008458:Measles Vaccine / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry; D051381:Rats; D011917:Rats, Inbred Lew; D012720:Severity of Illness Index; D040681:Structural Homology, Protein; D013552:Swine; D014611:Vaccination; D017778:Vaccines, Combined / Q000276:immunology*; D022223:Vaccines, Subunit / Q000276:immunology* / Q000627:therapeutic use; D014764:Viral Proteins / Q000276:immunology
D016056:Immunodominant Epitopes; D008458:Measles Vaccine; D004676:Myelin Basic Protein; D010455:Peptides; D017778:Vaccines, Combined; D022223:Vaccines, Subunit; D014764:Viral Proteins; D005620:Freund's Adjuvant