Mathematical and computational approaches can complement experimental studies of host-pathogen interactions.
In addition to traditional and novel experimental approaches to study host-pathogen interactions, mathematical and computer modelling have recently been applied to address open questions in this area. These modelling tools not only offer an additional avenue for exploring disease dynamics at multiple biological scales, but also complement and extend knowledge gained via experimental tools. In this review, we outline four examples where modelling has complemented current experimental techniques in a way that can or has already pushed our knowledge of host-pathogen dynamics forward. Two of the modelling approaches presented go hand in hand with articles in this issue exploring fluorescence resonance energy transfer and two-photon intravital microscopy. Two others explore virtual or 'in silico' deletion and depletion as well as a new method to understand and guide studies in genetic epidemiology. In each of these examples, the complementary nature of modelling and experiment is discussed. We further note that multi-scale modelling may allow us to integrate information across length (molecular, cellular, tissue, organism, population) and time (e.g. seconds to lifetimes). In sum, when combined, these compatible approaches offer new opportunities for understanding host-pathogen interactions.
Kirschner
Denise E
DE
Department of Microbiology and Immunology, 6730 Medical Science Bldg. II, University of Michigan Medical School, Ann Arbor, MI, USA. kirschne@umich.edu
Linderman
Jennifer J
JJ
D000818:Animals; D004195:Disease Models, Animal; D031541:Fluorescence Resonance Energy Transfer; D054884:Host-Pathogen Interactions; D006801:Humans; D008853:Microscopy / Q000379:methods; D008954:Models, Biological; D008967:Molecular Biology; D017785:Photons