title: IFN-gamma down-regulates Secretoglobin 3A1 gene expression.
abstract: STAT1 mediates Interferon (IFN)-dependent positive and negative regulation of inflammatory gene expression in lung. In this study, we examined the effect of IFN-gamma on the expression of SCGB3A1 which is thought to play crucial roles in inflammation and epithelial cell differentiation in lung. We found that expression of SCGB3A1 was down-regulated by IFN-gamma in a time- and dose-dependent manner in the murine transformed Clara Cells (mtCC) line. IFN-gamma induced the phosphorylation of STAT1, which binds to a STAT-binding element (SBE) in the SCGB3A1 gene promoter, leading to decreased transcriptional activation of this gene.
authors.affiliation: Department of Biochemistry, School of Dentistry, Showa University, Shinagawa, Tokyo 142-8555, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamada
authors.forename: Dai
authors.initials: D
authors.lastname: Suzuki
authors.forename: Agasa
authors.initials: A
authors.lastname: Miyazono
authors.forename: Kumiko
authors.initials: K
authors.lastname: Oshima
authors.forename: Akihide
authors.initials: A
authors.lastname: Kamiya
authors.forename: Baohong
authors.initials: B
authors.lastname: Zhao
authors.forename: Masamichi
authors.initials: M
authors.lastname: Takami
authors.forename: Raymond P
authors.initials: RP
authors.lastname: Donnelly
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Itabe
authors.forename: Matsuo
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Shioko
authors.initials: S
authors.lastname: Kimura
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Kamijo
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D015870:Gene Expression / Q000187:drug effects*; D007371:Interferon-gamma / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D011401:Promoter Regions, Genetic / Q000187:drug effects; D011506:Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics; D017471:Receptors, Interferon / Q000378:metabolism; D011994:Recombinant Proteins; D050794:STAT1 Transcription Factor / Q000378:metabolism; D000096743:Interferon gamma Receptor
chemical_list: D007371:Interferon-gamma; D011506:Proteins; D017471:Receptors, Interferon; D011994:Recombinant Proteins; D050794:STAT1 Transcription Factor; D000096743:Interferon gamma Receptor; C494080:Stat1 protein, mouse; C470307:UGRP2 protein, mouse