title: FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.
abstract: Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and alpha-synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient-control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and alpha-synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and alpha-synuclein protein levels.
authors.affiliation: Department of Neuroscience, Mayo Clinic, Jacksonville, Florida 32224, USA. wider.christian@mayo.edu
authors.forename: Christian
authors.initials: C
authors.lastname: Wider
authors.forename: Justus C
authors.initials: JC
authors.lastname: Dachsel
authors.forename: Alexandra I
authors.initials: AI
authors.lastname: Soto
authors.forename: Michael G
authors.initials: MG
authors.lastname: Heckman
authors.forename: Nancy N
authors.initials: NN
authors.lastname: Diehl
authors.forename: Mei
authors.initials: M
authors.lastname: Yue
authors.forename: Sarah
authors.initials: S
authors.lastname: Lincoln
authors.forename: Jan O
authors.initials: JO
authors.lastname: Aasly
authors.forename: Kristoffer
authors.initials: K
authors.lastname: Haugarvoll
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: Spiridon
authors.initials: S
authors.lastname: Papapetropoulos
authors.forename: Deborah
authors.initials: D
authors.lastname: Mash
authors.forename: Alex
authors.initials: A
authors.lastname: Rajput
authors.forename: Ali H
authors.initials: AH
authors.lastname: Rajput
authors.forename: J Mark
authors.initials: JM
authors.lastname: Gibson
authors.forename: Timothy
authors.initials: T
authors.lastname: Lynch
authors.forename: Dennis W
authors.initials: DW
authors.lastname: Dickson
authors.forename: Ryan J
authors.initials: RJ
authors.lastname: Uitti
authors.forename: Zbigniew K
authors.initials: ZK
authors.lastname: Wszolek
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Farrer
authors.forename: Owen A
authors.initials: OA
authors.lastname: Ross
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D051844:alpha-Synuclein / Q000235:genetics*
chemical_list: C416003:FGF20 protein, human; D051844:alpha-Synuclein; D005346:Fibroblast Growth Factors