Photopolymerization of methacrylated chitosan/PNIPAAm hybrid dual-sensitive hydrogels as carrier for drug delivery.
A series of hybrid hydrogels based on glycidyl methacrylated chitosan (CS-GMA) and N-isopropylacrylamide (NIPAAm) were designed and prepared via photopolymerization technology. The hydrogels were characterized by Fourier transform infrared (FT-IR), differential scanning calorimetry (DSC) and optical transmittance. The interior morphology of hydrogels was investigated by scanning electron microscopy (SEM). The swelling experiment results revealed that hybrid hydrogel exhibited combined pH and temperature sensitivities. Acid orange 8 (AO8) and 5-flurouracil (5-Fu) were selected as model drugs for examining their release from hydrogels. The results suggested that hydrogel composition and pH value of buffer solution had great influences on release profiles.
Han
Jing
J
Beijing University of Chemical Technology, PR China.
Wang
Kemin
K
Yang
Dongzhi
D
Nie
Jun
J
D000165:Acridine Orange / Q000737:chemistry; D000178:Acrylamides / Q000737:chemistry / Q000528:radiation effects*; D000180:Acrylic Resins; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000528:radiation effects*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005472:Fluorouracil / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008027:Light; D008855:Microscopy, Electron, Scanning; D044367:Phase Transition; D011108:Polymers / Q000737:chemistry / Q000528:radiation effects*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D004337:Drug Carriers; D020100:Hydrogels; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D048271:Chitosan; D000165:Acridine Orange; D005472:Fluorouracil