Antimicrobial activity of stereoisomers of morinols a and B, tetrahydropyran sesquineolignans.
The antimicrobial activity of all stereoisomers of morinols A and B was tested. All stereoisomers of morinols A and B showed antifungal activity against Alternaria alternata, especially (-)-morinol B which showed the strongest activity. The natural component, (+)-morinol A, and unnatural stereoisomer, (7S,7'S,8R,8'R)-morinol B, showed antibacterial activity against the gram-positive bacteria, Bacillus subtilis and Listeria denitrificans.
Akiyama
Koichi
K
Integrated Center for Sciences, Tarumi Station, Ehime University.
Yamauchi
Satoshi
S
Maruyama
Masafumi
M
Sugahara
Takuya
T
Kishida
Taro
T
Koba
Yojiro
Y
D000528:Alternaria; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D001412:Bacillus subtilis; D006094:Gram-Positive Bacteria; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D008087:Listeria; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D017705:Lignans; D011714:Pyrans; C519741:morinol A; C519740:morinol B