title: Clinical immunology review series: An approach to the management of pulmonary disease in primary antibody deficiency.
abstract: The sinopulmonary tract is the major site of infection in patients with primary antibody deficiency syndromes, and structural lung damage arising from repeated sepsis is a major determinant of morbidity and mortality. Patients with common variable immunodeficiency may, in addition, develop inflammatory lung disease, often associated with multi-system granulomatous disease. This review discusses the presentation and management of lung disease in patients with primary antibody deficiency.
authors.affiliation: Department of Clinical Immunology, The Royal London Hospital, Whitechapel, UK.
authors.forename: M D
authors.initials: MD
authors.lastname: Tarzi
authors.forename: S
authors.initials: S
authors.lastname: Grigoriadou
authors.forename: S B
authors.initials: SB
authors.lastname: Carr
authors.forename: L M
authors.initials: LM
authors.lastname: Kuitert
authors.forename: H J
authors.initials: HJ
authors.lastname: Longhurst
mesh_terms: D001987:Bronchiectasis / Q000150:complications / Q000628:therapy; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D008171:Lung Diseases / Q000175:diagnosis / Q000628:therapy*; D009894:Opportunistic Infections / Q000150:complications / Q000628:therapy; D011014:Pneumonia / Q000150:complications / Q000628:therapy; D014057:Tomography, X-Ray Computed