Is the urinary protein excretion pattern compatible with renal morphological findings in renal amyloidosis?
The aims of this study are to compare urinary protein excretion pattern with renal morphological findings and to find out whether urinary protein excretion pattern is a prognostic indicator of renal amyloidosis. Fifteen children with renal amyloidosis secondary to familial Mediterranean fever were included in the study. The patients were classified into three groups according to the degree of tubulointerstitial injury in renal biopsy (group 1, <25%; group 2, 25-50%; and group 3, >50%). In all patients, urinary protein electrophoresis were performed. Levels of urinary beta(2)-microglobulin, retinol binding protein, and beta.N-acetyl-D glucosaminidase were measured as markers for tubular injury, and urinary excretions of protein and albumin and plasma albumin levels were measured as markers of glomerular injury. While urinary excretions of protein and albumin and plasma albumin levels were not different between groups, higher urinary beta(2-)microglobulin and retinol binding protein values and lower creatinine clearance values were found in group 3 than in groups 1 and 2 (p < 0.05). We concluded that analysis of urinary protein excretion pattern is a non-invasive and reliable method to detect the degree of tubulointerstitial injury as the most important prognostic factor in renal amyloidosis and may be used to determine the changes during the follow-up period of the patients.
Erdoğan
Ozlem
O
Department of Pediatric Nephrology, Dr. Sami Ulus Children's Hospital, Ankara, Turkey. erdogan65@yahoo.com
Demircin
Gülay
G
Bülbül
Mehmet
M
Memiş
Leyla
L
Oner
Ayşe
A
D000118:Acetylglucosaminidase / Q000378:metabolism; D000293:Adolescent; D000686:Amyloidosis / Q000201:enzymology / Q000473:pathology* / Q000652:urine*; D002648:Child; D015331:Cohort Studies; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000201:enzymology / Q000473:pathology* / Q000652:urine*; D008297:Male; D011237:Predictive Value of Tests; D011507:Proteinuria / Q000097:blood / Q000201:enzymology / Q000473:pathology*; D015203:Reproducibility of Results; D012177:Retinol-Binding Proteins / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000378:metabolism
D012177:Retinol-Binding Proteins; D012709:Serum Albumin; D001613:beta 2-Microglobulin; D003404:Creatinine; D000118:Acetylglucosaminidase