Doripenem: a new addition to the carbapenem class of antimicrobials.
Doripenem (DPM) is the newest antimicrobial in the carbapenem class. It is a broad spectrum agent with activity against gram-positive, gram-negative and anaerobic bacteria. in vitro Susceptibility testing has demonstrated potent activity for many drug resistant gram-negative pathogens including some that are resistant to imipenem and meropenem. It appears to be less likely to induce resistance for certain pathogens compared to the other carbapenems. The purpose of this review is to introduce DPM and describe its potential role in managing infections due to multi-drug resistant gram-negative bacteria. This article also reviews recent patents related to the carbapenem class of antimicrobials.
Schafer
Jason J
JJ
UPMC St. Margaret Hospital Department of Pharmacy, Pittsburgh, Pennsylvania 15215, USA. schaferjj@upmc.edu
Goff
Debra A
DA
Mangino
Julie E
JE
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D003428:Cross Infection / Q000188:drug therapy; D000077726:Doripenem; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D053717:Pneumonia, Ventilator-Associated / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem