title: Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility.
abstract: Expanded CGG repeats cause chromosomal fragility and hereditary neurological disorders in humans. Replication forks stall at CGG repeats in a length-dependent manner in primate cells and in yeast. Saccharomyces cerevisiae proteins Tof1 and Mrc1 facilitate replication fork progression through CGG repeats. Remarkably, the fork-stabilizing role of Mrc1 does not involve its checkpoint function. Thus, chromosomal fragility might occur when forks stalled at expanded CGG repeats escape the S-phase checkpoint.
authors.affiliation: Department of Biology, Tufts University, 165 Packard Avenue, Medford, Massachusetts 02155, USA.
authors.forename: Irina
authors.initials: I
authors.lastname: Voineagu
authors.forename: Christine F
authors.initials: CF
authors.lastname: Surka
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Shishkin
authors.forename: Maria M
authors.initials: MM
authors.lastname: Krasilnikova
authors.forename: Sergei M
authors.initials: SM
authors.lastname: Mirkin
mesh_terms: D000818:Animals; D019556:COS Cells; D002522:Chlorocebus aethiops; D002873:Chromosome Fragility; D004261:DNA Replication; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D018911:Trinucleotide Repeats