title: Strategic plan for pediatric respiratory diseases research: an NHLBI working group report.
abstract: The Division of Lung Diseases of the National Heart, Lung, and Blood Institute (NHLBI) recently held a workshop to identify gaps in our understanding and treatment of childhood lung diseases and to define strategies to enhance translational research in this field. Leading experts with diverse experience in both laboratory and patient-oriented research reviewed selected areas of pediatric lung diseases, including perinatal programming and epigenetic influences; mechanisms of lung injury, repair, and regeneration; pulmonary vascular disease; sleep and control of breathing; and the application of novel translational methods to enhance personalized medicine. This report summarizes the proceedings of this workshop and provides recommendations for emphasis on targeted areas for future investigation. The priority areas identified for research in pediatric pulmonary diseases included: (1) epigenetic and environmental influences on lung development that program pediatric lung diseases; (2) injury, regeneration, and repair in the developing lung; (3) pulmonary vascular disease in children; (4) development and adaptation of ventilatory responses to postnatal life; (5) nonatopic wheezing: aberrant large airway development or injury?; (6) strategies to improve assessment, diagnosis, and treatment of pediatric respiratory diseases; and (7) predictive and personalized medicine for children.
authors.affiliation: Washington University School of Medicine, Medicine and Pediatrics, St. Louis, Missouri, USA.
authors.forename: Mario
authors.initials: M
authors.lastname: Castro
authors.forename: Maria I
authors.initials: MI
authors.lastname: Ramirez
authors.forename: James E
authors.initials: JE
authors.lastname: Gern
authors.forename: Garry
authors.initials: G
authors.lastname: Cutting
authors.forename: Greg
authors.initials: G
authors.lastname: Redding
authors.forename: James S
authors.initials: JS
authors.lastname: Hagood
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Whitsett
authors.forename: Steve
authors.initials: S
authors.lastname: Abman
authors.forename: J Usha
authors.initials: JU
authors.lastname: Raj
authors.forename: Robyn
authors.initials: R
authors.lastname: Barst
authors.forename: Gregory J
authors.initials: GJ
authors.lastname: Kato
authors.forename: David
authors.initials: D
authors.lastname: Gozal
authors.forename: Gabriel G
authors.initials: GG
authors.lastname: Haddad
authors.forename: Nanduri R
authors.initials: NR
authors.lastname: Prabhakar
authors.forename: Estelle
authors.initials: E
authors.lastname: Gauda
authors.forename: Fernando D
authors.initials: FD
authors.lastname: Martinez
authors.forename: Robert
authors.initials: R
authors.lastname: Tepper
authors.forename: Robert E
authors.initials: RE
authors.lastname: Wood
authors.forename: Frank
authors.initials: F
authors.lastname: Accurso
authors.forename: W Gerald
authors.initials: WG
authors.lastname: Teague
authors.forename: Jose
authors.initials: J
authors.lastname: Venegas
authors.forename: F Sessions
authors.initials: FS
authors.lastname: Cole
authors.forename: Rosalind J
authors.initials: RJ
authors.lastname: Wright
mesh_terms: D035843:Biomedical Research / Q000458:organization & administration*; D006801:Humans; D009316:National Institutes of Health (U.S.); D010372:Pediatrics; D012120:Respiration Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D014481:United States