title: Multicomponent synthesis of alpha-branched amides.
abstract: Alpha-branched amides are prepared by multicomponent reactions in which nitriles undergo hydrozirconation to form metalloimines that react with acyl chlorides. The resulting acylimines react with a variety of pi-nucleophiles in the presence of Lewis acids to form the desired amides.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Mikkel V
authors.initials: MV
authors.lastname: DeBenedetto
authors.forename: Michael E
authors.initials: ME
authors.lastname: Green
authors.forename: Shuangyi
authors.initials: S
authors.lastname: Wan
authors.forename: Jung-Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Paul E
authors.initials: PE
authors.lastname: Floreancig
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry
chemical_list: D000577:Amides; D009570:Nitriles; D015040:Zirconium