Metabolism in rats during antiorthostatic hypokinesia.
O2 consumption and CO2 release in 3 groups of awake rats were studied on a MM-100 metabolic monitor system (CWE Inc.). The animals of 2 groups were preadapted to 4-h maintenance in special boxes (2 weeks). The rats could perform rotational movements and limited movements in the rostrocaudal direction (hypokinesia). The animals of one group were daily exposed to 4-h antiorthostatic load (<or=45 degrees) for 2 weeks. After 2 weeks, the intensity of metabolism in rats with antiorthostatic hypokinesia was lower than in hypokinetic specimens (by 15-20%, p<0.05) and freely moving animals (by 20-25%, p<0.05). Interleukin-6 concentration in rats with antiorthostatic hypokinesia (0.25+/-0.09 pg/ml) was lower than in hypokinetic (4.01+/-0.57 pg/ml) and freely moving animals (3.69+/-0.56 pg/ml). The decrease in the concentration of a proinflammatory cytokine interleukin-6 during experimental antiorthostatic hypokinesia reflects inhibition of metabolic processes, which are activated during antiorthostatism (but not hypokinesia).
Novoselova
A M
AM
Department of Physiology and General Pathology, Institute of Physiology, National Academy of Sciences, Belarus, Minsk.
Custaud
M A
MA
Tsvirkun
D V
DV
Larina
I M
IM
Kulchitsky
V A
VA
D000818:Animals; D001831:Body Temperature; D002245:Carbon Dioxide / Q000378:metabolism; D004734:Energy Metabolism; D018476:Hypokinesia; D007103:Immobilization / Q000502:physiology*; D009043:Motor Activity / Q000502:physiology; D010101:Oxygen Consumption; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical
D002245:Carbon Dioxide