title: Enantioselective and catalytic method for alpha-crotylation of aldehydes with a kinetic self-refinement of stereochemistry.
abstract: Kinetic refinery: A practical, highly stereoselective, two-step catalytic protocol for the alpha-allylation of aldehydes, starting from crotyltrichlorosilanes, has been developed (see scheme). In each reaction step, one of the stereoisomers reacted faster than the other, which resulted in a kinetic stereochemical (E/Z) self-refinement of the system and led to the formation of virtually enantiomerically and geometrically pure linear homoallylic alcohols in high yield.
authors.affiliation: Department of Chemistry, WestChem, University of Glasgow, Glasgow G12 8QQ, UK. a.malkov@lboro.ac.uk
authors.forename: Andrei V
authors.initials: AV
authors.lastname: Malkov
authors.forename: Mikhail A
authors.initials: MA
authors.lastname: Kabeshov
authors.forename: Maciej
authors.initials: M
authors.lastname: Barłog
authors.forename: Pavel
authors.initials: P
authors.lastname: Kocovský