title: The secret life of Smad4.
abstract: Smad4 is an important mediator of signaling by TGFbeta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.
authors.affiliation: Center for Systems Biology, Mount Sinai Hospital, Toronto M5G 1X5, Canada. wrana@lunenfeld.ca
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Wrana
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D051901:Smad4 Protein / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000378:metabolism; D043222:Ubiquitin Thiolesterase / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D004268:DNA-Binding Proteins; D051901:Smad4 Protein; D016212:Transforming Growth Factor beta; D043222:Ubiquitin Thiolesterase