Functional activity of isolated perfused rat liver depends on medium composition.
It is convenient to study liver function and metabolism on the model of isolated perfused organ. The results of the present study indicate that viability and metabolic activity of the organ largely depend on the composition of the medium. Under conditions of isolated perfusion, the known pathway of oxygen transport through capillary filtration is supplemented by oxygen delivery to cells through the organ surface making an important contribution to liver oxygenation.
Rupenko
A P
AP
International Center for Research of Critical States, Siberian Division of Russian Academy of Sciences, Russia.
Kruglik
O V
OV
Morgulis
I I
II
D000818:Animals; D003470:Culture Media / Q000737:chemistry*; D005260:Female; D008099:Liver / Q000033:anatomy & histology / Q000378:metabolism; D008102:Liver Circulation / Q000502:physiology*; D010101:Oxygen Consumption; D010477:Perfusion / Q000379:methods*; D051381:Rats; D017208:Rats, Wistar; D046509:Tissue Culture Techniques
D003470:Culture Media