Investigation of sp(2)-sp coupling for electron-enriched aryl dihalides under oxygen-free Sonogashira coupling reaction conditions using a two-chamber reaction system.
Triethylamine hydroiodide crystals were formed during Sonogashira reactions; after complete reaction the solution retains a characteristic light color (see picture). Very sluggish Sonogashira reactions of electron-enriched aryl diiodides have been carried out in high yield in an oxygen-free, two-chamber reaction system. The formation of triethylamine hydroiodide crystals was monitored to determine the completion of reaction.
Chen
Xue-Yi
XY
Department of Chemistry, University of Missouri- Kansas City, Kansas City, MO 64110, USA.
Barnes
Charles
C
Dias
Jerry R
JR
Sandreczki
T C
TC