title: Transition of psoriasiform drug eruption to psoriasis de novo evidenced by histopathology.
abstract: Drug reaction can be one of the triggering factors either for exacerbation of pre-existing psoriasis or precipitation of psoriasis de novo. Herein, we report a case with psoriasiform drug eruption due to pravastatin, but it relapsed after discontinuance of the drug. Serial investigation of the histopathology and immunohistochemistry with anti-signal transducer and activator of transcription 3 (STAT3) revealed drug reaction-associated lesions intermingled with psoriasiform changes, which later predominated, suggesting a conversion into psoriasis de novo.
authors.affiliation: Department of Dermatology, Kochi Medical School, Kochi University, Nankoku, Kochi, Japan.
authors.forename: Mayuko
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Ikeda
authors.forename: Hajime
authors.initials: H
authors.lastname: Kodama
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Sano
mesh_terms: D000369:Aged, 80 and over; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects*; D017035:Pravastatin / Q000009:adverse effects*; D011565:Psoriasis / Q000139:chemically induced* / Q000473:pathology; D012867:Skin / Q000473:pathology*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D017035:Pravastatin