Pharmacokinetic comparison of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia: influence of disease state.
OBJECTIVE
An investigation has been designed and conducted to compare the pharmacokinetics of puerarin after oral administration of Jiawei-Xiaoyao-San to healthy volunteers and to patients with functional dyspepsia.


METHODS
Quantification of puerarin in serum was achieved using a simple and rapid HPLC method for pharmacokinetic study.


RESULTS
After oral administration of decoctions of Jiawei-Xiaoyao-San to healthy volunteers and patients with functional dyspepsia, puerarin was absorbed and reached a maximum concentration of 56.47+/-15.60 and 29.40+/-8.89 ng/ml at 51.00+/-8.22 and 50.00+/-12.25 min, respectively. Compared with the value of AUC0-360 (5.55+/-1.47 microg/ml min) in healthy volunteers, a smaller value of AUC0-360 (3.35+/-1.17 microg/ml min) was observed in patients with functional dyspepsia.


CONCLUSIONS
There were statistically significant differences in the pharmacokinetic parameters of puerarin including the values for Cmax, AUC0-360, Cl/F and MRT0-360 between healthy volunteers and patients with functional dyspepsia. The pharmacokinetic parameters showed that functional dyspepsia reduced the absorption of puerarin after oral administration of Jiawei-Xiaoyao-San.
Qin
Feng
F
Laboratory of Ethnopharmacology and Department of Integrated Chinese and Western Medicine, Xiangya Hospital, Central South University, Changsha, China.
Huang
Xi
X
Zhang
Hong-Min
HM
Ren
Ping
P
D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004415:Dyspepsia / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007529:Isoflavones / Q000097:blood / Q000493:pharmacokinetics*; D016018:Least-Squares Analysis; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D013997:Time Factors; D014665:Vasodilator Agents / Q000097:blood / Q000493:pharmacokinetics; D055815:Young Adult
D004365:Drugs, Chinese Herbal; D007529:Isoflavones; D014665:Vasodilator Agents; C103354:kamisyoyo san; C033607:puerarin