Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells.
The antigenotoxic effect of apigenin was studied against the genotoxic damage induced by mitomycin C on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Apigenin was studied at three different doses i.e. 10, 20 and 40 mg/kg b.w. and was found to be non-genotoxic at all the above three doses. Mitomycin C at 2 mg/kg b.w. was given along with the 10, 20 and 40 mg/kg bw of apigenin. A significant decrease in SCEs and CAs was observed, suggesting a protective role of apigenin against the genotoxicity of mitomycin C on mice bone marrow cells.
Siddique
Yasir Hasan
YH
Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P. 202 002, India. yasir_hasansiddique@rediffmail.com
Afzal
Mohammad
M
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D047310:Apigenin / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D016685:Mitomycin / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange
D016587:Antimutagenic Agents; D009153:Mutagens; D016685:Mitomycin; D047310:Apigenin