title: A facile synthesis of pyridazinone derivatives under ultrasonic irradiation.
abstract: A new, efficient and general method for preparation of N-substituted-pyridazinones using ultrasound irradiation is reported. Under ultrasound the reaction time decreases substantially, the yields are high and the reaction conditions are mild. It was noticed that substituents at the 3-(6)-position of pyridazone heterocycle have a substantial influence on the reactivity, while the effect of the substituents at the 1-(2)-position seems to be of minor importance. A comparative study of the reactions performed under ultrasound conditions versus at room temperature has been done.
authors.affiliation: Al. I. Cuza University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania.
authors.forename: Dorina
authors.initials: D
authors.lastname: Mantu
authors.forename: Costel
authors.initials: C
authors.lastname: Moldoveanu
authors.forename: Alina
authors.initials: A
authors.lastname: Nicolescu
authors.forename: Calin
authors.initials: C
authors.lastname: Deleanu
authors.forename: Ionel I
authors.initials: II
authors.lastname: Mangalagiu
mesh_terms: D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature; D014465:Ultrasonics
chemical_list: D011724:Pyridazines