title: [Anal fissure].
abstract: Chronic anal fissure is an ischemic ulcer related to hypertonic sphincter. Pain and bleeding are the most common complaints. In first instance, treatment combines laxatives, analgesic and ointments. Topical nitrates represent a challenging alternative to surgery where non-specific approaches failed.
authors.affiliation: Service des maladies de l'appareil digestif CHU Rennes, hôpital Pontchaillou, 35033 Rennes Cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Bouguen
authors.forename: Marianne
authors.initials: M
authors.lastname: Eléouet
authors.forename: Charlotte
authors.initials: C
authors.lastname: Favreau
authors.forename: Laurent
authors.initials: L
authors.lastname: Siproudhis
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000627:therapeutic use; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use; D002908:Chronic Disease; D002921:Cicatrix; D005401:Fissure in Ano / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D006801:Humans; D054368:Laxatives / Q000008:administration & dosage / Q000627:therapeutic use; D009824:Ointments; D012008:Recurrence
chemical_list: D000700:Analgesics; D002121:Calcium Channel Blockers; D054368:Laxatives; D009824:Ointments; D019274:Botulinum Toxins, Type A