title: Stem cell factors in plants: chromatin connections.
abstract: The progression of pluripotent stem cells to differentiated cell lineages requires major shifts in cell differentiation programs. In both mammals and higher plants, this process appears to be controlled by a dedicated set of transcription factors, many of which are kingdom specific. These divergent transcription factors appear to operate, however, together with a shared suite of factors that affect the chromatin state. It is of major importance to investigate whether such shared global control mechanisms indicate a common mechanistic basis for preservation of the stem cell state, initiation of differentiation programs, and coordination of cell state transitions.
authors.affiliation: Department of Molecular Cell Biology, Utrecht University, 3584 CH Utrecht, The Netherlands.
authors.forename: N
authors.initials: N
authors.lastname: Kornet
authors.forename: B
authors.initials: B
authors.lastname: Scheres
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D044127:Epigenesis, Genetic; D017343:Genes, Plant; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008322:Mammals; D051379:Mice; D008954:Models, Biological; D059828:Plant Cells; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000378:metabolism*; D039904:Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D006657:Histones; D010940:Plant Proteins; D014157:Transcription Factors