title: In vitro anti-influenza viral activities of constituents from Caesalpinia sappan.
abstract: Six constituents with neuraminidase (NA) inhibitory activity, namely brazilein, brazilin, protosappanin A, 3-deoxysappanchalcone, sappanchalcone and rhamnetin, were isolated from the hearthwood of Caesalpinia sappan (Leguminosae). Their in vitro anti-influenza virus activities were evaluated with the cytopathic effect (CPE) reduction method. The results showed that 3-deoxysappanchalcone and sappanchalcone exhibited the highest activity against influenza virus (H3N2) with IC50 values of 1.06 and 2.06 microg/mL, respectively, in comparison to the positive control oseltamivir acid and ribavirin with IC50 values of 0.065 and 9.17 microg/mL, respectively.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, PR China.
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Liu
authors.forename: Shi-Hui
authors.initials: SH
authors.lastname: Shu
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Qin
authors.forename: Simon Ming Yuen
authors.initials: SM
authors.lastname: Lee
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Wang
authors.forename: Guan-Hua
authors.initials: GH
authors.lastname: Du
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology*; D029911:Caesalpinia / Q000737:chemistry*; D002460:Cell Line; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009980:Influenza A virus / Q000187:drug effects*; D009981:Influenza B virus / Q000187:drug effects*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D010936:Plant Extracts