The relationship between dysglycemia and cognitive dysfunction.
With the aging of the population, the prevalence of two common disorders is expected to rise: diabetes and dementia. It has been shown that people with diabetes are approximately 1.5-fold more likely to experience cognitive decline and 1.6-fold more likely to develop frank dementia than individuals without diabetes. This is likely due to a higher prevalence of both vascular dementia and Alzheimer's disease. The aim of this review is to describe the importance of this relationship, the evidence supporting it and possible explanations, and the possible role of insulin and insulin resistance in this relationship.
Cukierman-Yaffee
Tali
T
Gertner Institute for Epidemiology & Health Policy Research, Endocrinology Institute, Sheba Medical Center, Epidemiology Department, Sackler School of Medicine, Tel-Aviv University, Israel. cukierm@mcmaster.ca
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology* / Q000378:metabolism; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D015995:Prevalence
D001786:Blood Glucose; D007328:Insulin