Swiss cheese et allii, some of the first neurodegenerative mutants isolated in Drosophila.
Drosophila has only recently become a model organism to study progressive neurodegeneration, mainly using transgenic flies expressing human disease genes. However, classical forward genetics isolating and characterizing fly mutants that show characteristic features of progressive neurodegeneration can also provide a useful tool to get insights into the mechanisms of neurodegeneration. Interestingly, the first such mutants have been already isolated in the 1970s, and this review focuses on the description of four such mutants originally isolated by Martin Heisenberg.
Kretzschmar
Doris
D
Center for Research on Occupational and Environmental Toxicology, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA. kretzsch@ohsu.edu
D000818:Animals; D004195:Disease Models, Animal; D029721:Drosophila Proteins / Q000235:genetics*; D004331:Drosophila melanogaster / Q000235:genetics*; D017344:Genes, Insect; D009154:Mutation; D009410:Nerve Degeneration / Q000235:genetics* / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020825:T-Box Domain Proteins / Q000235:genetics; D014617:Vacuoles / Q000473:pathology
D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; C108350:SWS protein, Drosophila; D020825:T-Box Domain Proteins; C072962:bi protein, Drosophila