Ionic liquids promote amyloid formation from alpha-synuclein.
The slow process required for alpha-synuclein to form amyloid fibrils is a major obstacle in the development of therapeutic compounds for alpha-synuclein-related neurodegenerative diseases such as Parkinson's disease (PD). Here we have developed an efficient method by which amyloid fibrils can be formed from alpha-synuclein using ionic liquids (ILs). This report indicates that ILs could potentially be used as a stimulator for the amyloid formation of alpha-synuclein.
Hwang
Heejin
H
Department of Molecular Science and Technology, Graduate School of Interdisciplinary Program, Ajou University, Suwon 443-749, Republic of Korea.
Choi
Hyunghun
H
Kim
Hyun-Kyung
HK
Jo
Do Hyun
DH
Kim
T Doohun
TD
D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D051844:alpha-Synuclein / Q000737:chemistry* / Q000378:metabolism
D000682:Amyloid; D052578:Ionic Liquids; D051844:alpha-Synuclein