title: Effect of garlic (Allium sativum) on heavy metal (nickel II and chromium VI) induced alteration of serum lipid profile in male albino rats.
abstract: We have studied the effect of simultaneous oral treatment of aqueous garlic extract (Allium sativum) on heavy metal (nickel II and chromium VI) induced changes in serum lipid profile. Nickel sulfate and potassium dichromate treated rats showed a significant increase in serum low density lipoprotein-cholesterol (LDL-C), very low density lipoprotein-cholesterol (VLDL-C) and triglyceride (TG) level as well as decrease in serum high density lipoprotein-cholesterol (HDL-C) level. Simultaneous garlic administration with nickel sulfate showed improvement in serum LDL-C, HDL-C, VLDL-C and TG level. But in case of potassium dichromate, garlic administration did not show satisfactory improvement in lipid profile except VLDL-C and TG level. The results indicate that garlic (Allium sativum) has some beneficial effect in preventing heavy metal (nickel and chromium VI) induced alteration of lipid profile.
authors.affiliation: Environmental Health Research Unit, Department of Physiology, Al Ameen Medical College, Bijapur 586108 Karnataka, India.
authors.forename: Amrita
authors.initials: A
authors.lastname: Das Gupta
authors.forename: Swastika N
authors.initials: SN
authors.lastname: Das
authors.forename: Salim A
authors.initials: SA
authors.lastname: Dhundasi
authors.forename: Kusal K
authors.initials: KK
authors.lastname: Das
mesh_terms: D000818:Animals; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D015243:Cholesterol, VLDL / Q000097:blood / Q000187:drug effects; D005737:Garlic; D050356:Lipid Metabolism / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood / Q000187:drug effects; D008297:Male; D009532:Nickel / Q000494:pharmacology*; D008517:Phytotherapy; D010946:Plants, Medicinal; D011192:Potassium Dichromate / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D015243:Cholesterol, VLDL; D008055:Lipids; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C029938:nickel sulfate; D009532:Nickel; D011192:Potassium Dichromate