title: [Clinical effect of lifestyle modification on cardiovascular risk in prehypertensives: PREHIPER I study].
abstract: The objective was to determine the effect of lifestyle modification on cardiovascular risk in individuals with prehypertension, which is defined as a systolic blood pressure between 120 mmHg and 139 mmHg and a diastolic pressure between 80 mmHg and 89 mmHg. A randomized clinical trial was carried out in prehypertensives to compare those who took part in a program involving dietary modification, physical activity and educational sessions with those who followed normal recommendations. Cardiovascular risk was evaluated using the Framingham risk score and the chi-squared test, the Mann-Whitney U-test and the Friedman test. The mean Framingham score in the intervention group decreased from 5 (rank, -10 to 12) to 3.5 (rank, -11 to 10; P< .05) and the probability of a cardiovascular event at 10 years decreased from 5.29+/-3.88 to 4.24+/-2.86 (P< .05). This improvement was associated with a relative risk of 0.30 (95% confidence interval, 0.11 to 0.83) and a relative risk reduction of -69.8% (95% confidence interval -89% to -16.9%). There was no change in control subjects. Lifestyle modification decreased cardiovascular risk in individuals with prehypertension.
authors.affiliation: Unidad de Medicina Familiar No. 61, Instituto Mexicano del Seguro Social, Laguna de Alvarado 673, Veracruz, México. felixg.marquez@imss.gob.mx
authors.forename: Félix G
authors.initials: FG
authors.lastname: Márquez-Celedonio
authors.forename: Obdulia
authors.initials: O
authors.lastname: Téxon-Fernández
authors.forename: Adolfo
authors.initials: A
authors.lastname: Chávez-Negrete
authors.forename: Sergio
authors.initials: S
authors.lastname: Hernández-López
authors.forename: Sadoc
authors.initials: S
authors.lastname: Marín-Rendón
authors.forename: Susana
authors.initials: S
authors.lastname: Berlín-Lascurain
mesh_terms: D000328:Adult; D001786:Blood Glucose; D001794:Blood Pressure / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology; D008019:Life Style; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D018570:Risk Assessment; D012307:Risk Factors; D016540:Smoking Cessation; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose