Kinin formation in the plasma and cerebral blood flow in under conditions of cerebral ischemia/reperfusion in rats during modulation of kinin system activity.
Suppression of kininogenesis is an adaptive phenomenon in cerebral ischemia/reperfusion in rats aimed at elimination of the no-reflow phenomenon. Hyperkininogenesis and suppression of kinin destruction are pathogenetically significant, because they augment the manifestations of no-reflow phenomenon during reperfusion following ischemia.
Orobei
M V
MV
Department of Pathophysiology, Altai State Medical University, Barnaul, Russia.
Kulikov
V P
VP
Shatillo
Y G
YG
D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D007705:Kinins / Q000097:blood*; D008297:Male; D010949:Plasma / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D015424:Reperfusion
D007705:Kinins