title: [Microflora of the open biotopes in systemic lupus erythematosus].
abstract: OBJECTIVE
  To study microflora of open biotopes and opportunistic mictoflora contamination of patients with systemic lupus erythematosus (SLE).
  
  
  METHODS
  Colon and nasal mucosa microflora was studied in 82 patients--52 SLE and 30 cardiological (control) patients. SLE diagnosis was made according to ARC 1982 criteria. Quantitative and qualitative characteristics of microflora were studied bacteriologically. The statistical data was analysed using STATISTICA 6.0 software package (Data analysis software system, StatSoft).
  
  
  RESULTS
  SLE patients' colon contains reduced amount of typical bacteria while the content of opportunistic intestinal bacteria, E. coli with changed enzymatic characteristics, staphylococci and agents with hemolytic activity rose. Enterobacteriaceae and coagula-positive staphylococci were detected on the nasal mucosa. Coagula-negative staphylococci were not frequent. Bacteriuria incidence and severity increased significantly. Opportunistic intestinal bacteria and Candida spp. were detected in SLE patients' urine.
  
  
  CONCLUSIONS
  The change of normal microflora of the open biotopes was observed in SLE, opportunistic microflora takes part in forming intestinal and mucosal microbiocenosis. The detected changes in the microflora demonstrate the development of intestinal dysbacteriosis in SLE patients and translocation of intestinal bacteria to atypical biotopes. The increased pool of gram-negative enterobacteria may contribute to maintenance of intoxication and inflammation. Contamination of the open biotopes with opportunistic bacteria raises the risk of pyoinflammatory complications in SLE patients.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Gul'neva
authors.forename: N P
authors.initials: NP
authors.lastname: Shilkina
mesh_terms: D001437:Bacteriuria / Q000453:epidemiology; D002177:Candidiasis / Q000453:epidemiology / Q000382:microbiology*; D004756:Enterobacteriaceae Infections / Q000453:epidemiology / Q000652:urine; D006801:Humans; D007422:Intestines / Q000382:microbiology; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000382:microbiology*; D009297:Nasal Mucosa / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000652:urine