title: Acquired epidermodysplasia verruciformis.
abstract: Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis with an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, this viral infection leads to the development of tinea versicolor-like macules on the trunk, neck, arms, and face during childhood, and over time, these lesions can progress to squamous cell carcinoma. More recently, an EV-like syndrome has been described in patients with impaired cell-mediated immunity. We describe two cases of EV-like syndrome in HIV-positive patients, review all previously reported cases of EV in patients with impaired cell-mediated immunity, introduce the term "acquired epidermodysplasia verruciformis" to describe EV developing in the immunocompromised host and examine the limited treatment options for these patients.
authors.affiliation: Department of Dermatology, Columbia University Medical Center, New York, New York, USA. hr2121@columbia.edu
authors.forename: Heather D
authors.initials: HD
authors.lastname: Rogers
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Macgregor
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Nord
authors.forename: Stephen
authors.initials: S
authors.lastname: Tyring
authors.forename: Peter
authors.initials: P
authors.lastname: Rady
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Engler
authors.forename: Marc E
authors.initials: ME
authors.lastname: Grossman
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D001706:Biopsy; D004819:Epidermodysplasia Verruciformis / Q000276:immunology / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications*