Prospects of metal complexes peripherally substituted with sugars in biomedicinal applications.
Metal complexes possess unique tunable properties, such as radioactivity, cytotoxicity or photophysical features, enabling them to act as diagnostic tracers or therapeutic agents. In applying them in biological systems, it is often necessary to enhance their solubility and biocompatibility. To achieve such goals, like the targeting of binding domains, transport systems and enzyme activities, the attachment of carbohydrate moieties appears to be suitable. Sugar-substitution in the periphery of metal complexes has therefore become a strongly growing field of research. Outlined herein is a selection of recent examples.
Gottschaldt
Michael
M
Laboratory for Organic and Macromolecular Chemistry, Friedrich-Schiller-University Jena, Humboldtstrasse 10, 07743 Jena, Germany. Michael.Gottschaldt@uni-jena.de
Schubert
Ulrich S
US
D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D003287:Contrast Media / Q000138:chemical synthesis / Q000737:chemistry; D051246:Glucose Transport Proteins, Facilitative / Q000378:metabolism; D057927:Hydrophobic and Hydrophilic Interactions; D028581:Lanthanoid Series Elements / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D037102:Lectins / Q000378:metabolism; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008670:Metals / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use*; D011485:Protein Binding; D011849:Radioactive Tracers
D002241:Carbohydrates; D003287:Contrast Media; D051246:Glucose Transport Proteins, Facilitative; D028581:Lanthanoid Series Elements; D037102:Lectins; D008024:Ligands; D008670:Metals; D009942:Organometallic Compounds; D011849:Radioactive Tracers