Allogeneic stem cell transplantation for severe aplastic anemia: graft rejection remains a problem.
We reviewed the outcome in 15 consecutive patients with severe aplastic anemia with a median age of 23 years who received matched sibling peripheral blood stem cell transplantation. Conditioning regimen was cyclophosphamide (Cy)+anti-thymocyte globulin (ATG). Cumulative incidence of transplant related mortality, graft failure, acute and chronic GVHD were 20%, 33%, 25%, and 8.3%, respectively. Conditioning with Cy only, resulted in higher rejection rate compared to Cy plus ATG (75% versus 12.5%, p=0.03). Eighty percent of patients are alive with a median follow-up of 19.5 (4.6-35.6) months. Two of the three patients who were re-transplanted with fludarabine had sustained donor chimerism.
Aki
Sahika Zeynep
SZ
Department of Hematology, Faculty of Medicine, Gazi University, Bilkent-1, Camlik Sitesi E-6 Blok, No. 18, 06533 Ankara, Turkey.
Sucak
Gülsan Türköz
GT
Ozkurt
Zübeyde Nur
ZN
Yeğin
Zeynep Arzu
ZA
Yağci
Münci
M
Haznedar
Rauf
R
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000401:mortality* / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D018572:Disease-Free Survival; D005260:Female; D006084:Graft Rejection / Q000401:mortality* / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D019653:Myeloablative Agonists / Q000008:administration & dosage; D036102:Peripheral Blood Stem Cell Transplantation; D015996:Survival Rate; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum; D007166:Immunosuppressive Agents; D019653:Myeloablative Agonists; D003520:Cyclophosphamide