title: Minor sperm abnormalities in young male post-pubertal patients with juvenile dermatomyositis.
abstract: The objective of the present study was to identify sperm abnormalities in young male patients with juvenile dermatomyositis (JDM). In 2005, 18 male JDM patients, diagnosed according to the criteria of Bohan and Peter, were followed at the Pediatric Rheumatology Unit and Rheumatology Division, of our Institution. Of the 18 males, 11 were pre-pubertal and 7 were post-pubertal. Two of 7 post-pubertal JDM male patients were excluded: one for orchidopexy for cryptorchidism and the other for testicular ectopia in the left testis. The remaining 5 post-pubertal JDM patients were prospectively evaluated on the basis of two semen analyses, according to the World Health Organization (WHO), urologic evaluation, testicular Doppler ultrasound hormone profile. The data of the JDM patients were compared with those of 5 age-matched healthy controls. The median age 18, was similar in JDM patients and controls. All JDM patients had teratozoospermia (abnormal sperm morphology), as did 4 (80%) of the controls. One of JDM patients had previous oligoasthenoteratozoospermia treated with intravenous cyclophosphamide with normalization of the number and concentration of the sperm after 5 years. All sperm parameters (sperm concentration, total sperm count and total motile sperm count by WHO, and sperm morphology by Kruger strict criteria), testicular volumes by Prader orchidometer and ultrasound, and hormones were similar in JDM patients compared with controls. The frequency of anti-sperm antibodies was similar in both groups. All JDM patients had minor sperm abnormalities in the head, midpiece, and/or tail of spermatozoids. Serial semen analyses in larger study populations are necessary to identify the extent and duration of sperm abnormalities in male patients with idiopathic inflammatory myopathies.
authors.affiliation: Unidade de Reumatologia Pediátrica, Departamento de Pediatria, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: A J P
authors.initials: AJ
authors.lastname: Moraes
authors.forename: R M R
authors.initials: RM
authors.lastname: Pereira
authors.forename: M
authors.initials: M
authors.lastname: Cocuzza
authors.forename: R
authors.initials: R
authors.lastname: Casemiro
authors.forename: O
authors.initials: O
authors.lastname: Saito
authors.forename: C A A
authors.initials: CA
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D053713:Azoospermia / Q000175:diagnosis; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D003882:Dermatomyositis / Q000150:complications* / Q000188:drug therapy; D006728:Hormones; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007248:Infertility, Male / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D011446:Prospective Studies; D011627:Puberty; D013076:Sperm Count; D013081:Sperm Motility; D055815:Young Adult
chemical_list: D006728:Hormones; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide