Negative regulation of Toll-like receptor signaling pathway.
TLRs are primary sensors of invading pathogens, recognizing conserved microbial molecules and activating signaling pathways that are pivotal to innate and adaptive immune responses. However, a TLR signaling pathway must be tightly controlled because its excessive activation can contribute to the pathogenesis of many human diseases. This review provides a summary of the different mechanisms that are involved in the negative regulation of TLR signaling pathways.
Wang
Jie
J
Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Hu
Yu
Y
Deng
Wei Wen
WW
Sun
Bing
B
D025461:Feedback, Physiological; D006801:Humans; D007107:Immune System / Q000502:physiology*; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology*
D051193:Toll-Like Receptors