title: [Multicenter study on the prevention of congenital toxoplasmosis in Buenos Aires].
abstract: Toxoplasmosis is an infection caused by Toxoplasma gondii, an intracellular parasite of universal distribution, with a variable prevalence depending on the region. This infection causes both morbidity and mortality in the fetus and newborn. The present study is an evaluation of the Argentine Consensus Guidelines regarding prenatal prevention of toxoplasmosis. Screening tests in pregnant women were done in nine different hospitals within the city of Buenos Aires and surroundings, where 19825 births between May 1st 2006 and April 30th 2007 were registered. Screening tests were done in 13632 pregnant women, using IgG and IgM determinations by ELISA. If acute infection was suspected, the patient's serum was sent to the reference laboratory to fulfill the pending tests: Sabin Feldman, ISAGA M, ISAGA A, ISAGA E and avidity. Clinical and serologic evaluation was done to all newborn of these mothers. Three hundred and fifty one specimens were sent and analyzed. Conclusions from the analysis were as follows: 121 (32%) patients probably acquired the infection during pregnancy, in 176 (46%) patients, acute infection was excluded, in 37 women (10%) serologic results were inconclusive, and in 47 (12%) the interpretation of results was impossible due to lack of information on the exact gestational age. Clinical and serologic control was performed in 94 newborns of mothers infected during pregnancy, and 5 congenital toxoplasmosis were detected, with fetal damage, four corioretinitis and one case of microcephaly. This study allowed us to validate the Argentine Consensus of Congenital Toxoplasmosis Guidelines.
authors.affiliation: Centro de toxoplasmosis y otras zoonosis, Hospital Alemán, Buenos Aires.
authors.forename: Liliana
authors.initials: L
authors.lastname: Carral
authors.forename: Federico
authors.initials: F
authors.lastname: Kaufer
authors.forename: Ricardo
authors.initials: R
authors.lastname: Durlach
authors.forename: Cristina
authors.initials: C
authors.lastname: Freuler
authors.forename: Patricia
authors.initials: P
authors.lastname: Olejnik
authors.forename: Mónica
authors.initials: M
authors.lastname: Nadal
authors.forename: Rosana
authors.initials: R
authors.lastname: Corazza
authors.forename: Marcela
authors.initials: M
authors.lastname: Pari
authors.forename: Liliana
authors.initials: L
authors.lastname: García
authors.forename: Sofía
authors.initials: S
authors.lastname: Córdoba
authors.forename: Mónica
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Mariana
authors.initials: M
authors.lastname: Ceriotto
authors.forename: Gabriela
authors.initials: G
authors.lastname: García
mesh_terms: D000465:Algorithms; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D001118:Argentina; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D008403:Mass Screening / Q000379:methods*; D011247:Pregnancy; D014122:Toxoplasma / Q000276:immunology*; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000276:immunology / Q000517:prevention & control
chemical_list: D000913:Antibodies, Protozoan; D007075:Immunoglobulin M