Myocardial (123)I-MIBG scintigraphy for differentiation of Lewy bodies disease from FTD.
Clinical distinction between Lewy bodies disease (LBD) and frontotemporal dementia (FTD) is sometimes difficult. Nigrostriatal dopaminergic degeneration occurs in both LBD and FTD, limiting helpfulness of DAT imaging to differentiate these forms of dementia. Several studies have emphasized the usefulness of myocardial scintigraphy with (123)Metaiodobenzylguanidine ((123)I-MIGB) in assessing the sympathetic nerve terminals in LBD demonstrating that cardiac (123)I-MIGB uptake is decreased in patients with this disease. We investigated the role of cardiac (123)I-MIBG scintigraphy in differentiating patients with LBD from those with FTD. Clinical diagnosis of LBD and FTD was determined according to established consensus criteria. Nine patients with LBD (1 possible and 8 probable), 6 patients with FTD, and 16 control subjects were involved in the study. The heart to mediastinum ratio (H/M) of (123)I-MIBG uptake was markedly reduced in all patients with LBD (H/M early: 1.25±0.12; delayed: 1.14±0.13) whereas it was normal in patients with FTD (H/M early: 1.86±0.20; delayed: 1.80±0.23) and in controls (H/M early: 1.91±0.17; delayed: 1.99±0.19), suggesting that cardiac (123)I-MIBG scintigraphy can help distinguish patients with LBD from those with FTD.
Novellino
Fabiana
F
Institute of Neurology, University Magna Graecia, Catanzaro, Italy.
Bagnato
Antonio
A
Salsone
Maria
M
Cascini
Giuseppe Lucio
GL
Nicoletti
Giuseppe
G
Arabia
Gennarina
G
Pugliese
Pierfrancesco
P
Morelli
Maurizio
M
Paglionico
Sandra
S
Cipullo
Stefania
S
Manna
Ida
I
De Marco
Elvira Valeria
EV
Condino
Francesca
F
Chiriaco
Carmelina
C
Morgante
Letterio
L
Zappia
Mario
M
Quattrone
Aldo
A
D019797:3-Iodobenzylguanidine; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D009483:Neuropsychological Tests; D019275:Radiopharmaceuticals; D018709:Statistics, Nonparametric; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging
D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine