title: The current knowledge on radiosensitivity of ovarian follicle development stages.
abstract: BACKGROUND
  The aim of this paper is to review the available information on ovarian radiation sensitivity and the genetic hazard of ionizing radiation in female mammals including humans.
  
  
  METHODS
  The literature present in the author's laboratories (international papers from the 1970s) was complemented by a Medline literature search using the keywords 'ionizing radiation genetic effects', 'oocyte radiosensitivity' and 'oocyte DNA repair' (1990-2008). Further articles were acquired from citations in the research papers and reports.
  
  
  RESULTS
  Animal data show that oocyte radiosensitivity varies widely according to the follicle/oocyte stage and the species. Oocytes near ovulation show the highest susceptibility to radiation induction of mutational events. Congenital anomalies have been observed after exposure to high doses (1-5 Gy), but extrapolation of these data to humans requires caution. In humans, the dose required to induce permanent ovarian failure would vary from 20.3 Gy at birth to 14.3 Gy at 30 years. Most epidemiological studies found little evidence of genetic diseases at the doses at which medical, occupational or accidental exposure occurred.
  
  
  CONCLUSIONS
  The fact that genetic effects were observed in irradiated animals suggests that these could also occur in humans. The probability of such events remains low compared with the 'spontaneous' risks of genetic effects.
authors.affiliation: Follicle Biology Laboratory, Free University of Brussels, Laarbeeklaan 101, B-1090 Jette, Belgium. iadriaen@gmail.com
authors.forename: I
authors.initials: I
authors.lastname: Adriaens
authors.forename: J
authors.initials: J
authors.lastname: Smitz
authors.forename: P
authors.initials: P
authors.lastname: Jacquet
mesh_terms: D000818:Animals; D033481:Chromosomes, Mammalian / Q000528:radiation effects; D006224:Cricetinae; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D009865:Oocytes / Q000528:radiation effects; D006080:Ovarian Follicle / Q000254:growth & development / Q000528:radiation effects*; D011839:Radiation, Ionizing; D051381:Rats