Enhancement of antibiotic elution from acrylic bone cement.
Antibiotic-loaded acrylic bone cement is a well-established tool in the prophylaxis and treatment of orthopedic infections. Numerous studies about its pharmacokinetic properties have demonstrated that only a small part of the incorporated antibiotic amounts can be released, mostly over the first 8-10 weeks. Therefore, in the past 10 years, several attempts have been made for enhancement of the drug elution from bone cement. This article reviews this experience and pays special attention on biantibiotic combinations, additives other than antimicrobial agents, as well as the effect of ultrasound on the antibiotic elution characteristics.
Anagnostakos
Konstantinos
K
Klinik für Orthopädie und Orthopädische Chirurgie, Universität des Saarlandes, Homburg/Saar, Germany. konstantinos.anagnostakos@unikliniksaarland.de)
Kelm
Jens
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements; D006801:Humans; D017053:Infection Control; D019904:Polymethyl Methacrylate
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D019904:Polymethyl Methacrylate