Sero-characterization of lipopolysaccharide from Burkholderia thailandensis.
We report the successful purification of lipopolysaccharide (LPS) from Burkholderia thailandensis, a Gram-negative bacterium, closely related to the highly pathogenic organisms B. pseudomallei and B. mallei. Burkholderia thailandensis LPS is shown to cross-react with rabbit and mouse sera obtained from inoculation with B. pseudomallei or B. mallei, respectively. These data suggest that B. thailandensis LPS shares similar structural features with LPS molecules from highly pathogenic Burkholderia species. This information may prove useful in ongoing efforts to develop novel vaccines and/or diagnostic reagents.
Qazi
Omar
O
Department of Pediatrics and the Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA.
Prior
Joann L
JL
Judy
Barbara M
BM
Whitlock
Gregory C
GC
Kitto
G Barrie
GB
Torres
Alfredo G
AG
Estes
D Mark
DM
Brown
Katherine A
KA
D000818:Animals; D019117:Burkholderia / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000737:chemistry / Q000302:isolation & purification*; D051379:Mice; D012329:RNA, Bacterial / Q000302:isolation & purification; D011817:Rabbits; D013045:Species Specificity
D008070:Lipopolysaccharides; D012329:RNA, Bacterial