[Growth inhibition of prostate cancer cells by epigallocatechin-3-gallate in the presence of Zn2+ in vitro].
In this paper, the cytotoxicity of EGCG against PC-3 prostate cancer cells and its molecular mechanism in the presence and absence of Zn2+ in vitro were investigated. The results showed that both EGCG and Zn2+ suppressed clonegenecity of PC-3 cells, and the suppression effect was enhanced in the coexist system of EGCG and Zn2+. MMP-9 is thought to play a significant role in cancer cell migration and invasion. In the present paper, the results showed that EGCG suppressed the activity of MMP-9 in PC-3 cells in the presence of Zn2+, as a result, migration ability of the cells was significantly decreased.
Zhang
Lan Cui
LC
Department of Tea Sciences, Zhejiang University, Hangzhou.
Shen
Sheng Rong
SR
Sun
Shi Li
SL
Yang
Jun Guo
JG
He
Guo Qing
GQ
Yu
Hai Ning
HN
D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015032:Zinc / Q000494:pharmacology*
D002392:Catechin; C045651:epigallocatechin gallate; D020780:Matrix Metalloproteinase 9; D015032:Zinc