Acquired epidermodysplasia verruciformis.
Epidermodysplasia verruciformis (EV) is a rare autosomal recessive genodermatosis with an increased susceptibility to specific human papillomavirus (HPV) genotypes. Classically, this viral infection leads to the development of tinea versicolor-like macules on the trunk, neck, arms, and face during childhood, and over time, these lesions can progress to squamous cell carcinoma. More recently, an EV-like syndrome has been described in patients with impaired cell-mediated immunity. We describe two cases of EV-like syndrome in HIV-positive patients, review all previously reported cases of EV in patients with impaired cell-mediated immunity, introduce the term "acquired epidermodysplasia verruciformis" to describe EV developing in the immunocompromised host and examine the limited treatment options for these patients.
Rogers
Heather D
HD
Department of Dermatology, Columbia University Medical Center, New York, New York, USA. hr2121@columbia.edu
Macgregor
Jennifer L
JL
Nord
Kristin M
KM
Tyring
Stephen
S
Rady
Peter
P
Engler
Danielle E
DE
Grossman
Marc E
ME
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D001706:Biopsy; D004819:Epidermodysplasia Verruciformis / Q000276:immunology / Q000473:pathology / Q000821:virology; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D030361:Papillomavirus Infections / Q000150:complications*