Role of polyethylene glycol integrity in specific receptor targeting of carbon nanotubes to cancer cells.
We demonstrate that dispersion of single walled carbon nanotubes (SWNTs) by ultrasonication with phospholipid-polyethylene glycol (PL-PEG) fragments it, thus interfering with its ability to block nonspecific uptake by cells. However, unfragmented PL-PEG promoted specific cellular uptake of targeted SWNTs to two distinct classes of receptors expressed by cancer cells. Since fragmentation is a likely consequence of ultrasonication, a technique commonly used to disperse SWNTs, this maybe a concern for certain applications such as drug delivery.
Zeineldin
Reema
R
College of Pharmacy, Mechanical Engineering, University of New Mexico, Albuquerque, New Mexico 87131, USA. reemaz@salud.unm.edu
Al-Haik
Marwan
M
Hudson
Laurie G
LG
D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D045744:Cell Line, Tumor; D066246:ErbB Receptors / Q000737:chemistry / Q000378:metabolism*; D058973:Folate Receptors, GPI-Anchored; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D012680:Sensitivity and Specificity; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013379:Substrate Specificity
D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D037742:Nanotubes, Carbon; D011956:Receptors, Cell Surface; D011092:Polyethylene Glycols; D066246:ErbB Receptors