title: Combined measurement of fasting plasma glucose and A1C is effective for the prediction of type 2 diabetes: the Kansai Healthcare Study.
abstract: OBJECTIVE
  We prospectively assessed whether the combined measurements of fasting plasma glucose (FPG) and A1C were effective for predicting type 2 diabetes.
  
  
  METHODS
  Study participants included 6,736 nondiabetic Japanese men aged 40-55 years. Type 2 diabetes was diagnosed in those who had an FPG >or=126 mg/dl or who were being treated with an oral antidiabetic agent or insulin. The models including FPG, A1C, and both were compared using the area under the receiver operating characteristic (AUROC) curves.
  
  
  RESULTS
  During the 4-year follow-up period, we confirmed 659 diabetes cases. In multivariate analysis, both FPG and A1C were independently associated with the risk of type 2 diabetes. The model including both FPG and A1C had a greater AUROC curve than that including FPG alone (0.853 vs. 0.818; P < 0.001) or A1C alone (0.853 vs. 0.771; P < 0.001).
  
  
  CONCLUSIONS
  The combined measurement of FPG and A1C was effective for predicting type 2 diabetes.
authors.affiliation: Department of Preventive Medicine and Environmental Health, Osaka City University Graduate School of Medicine, Osaka, Japan. ksato@med.osaka-cu.ac.jp
authors.forename: Kyoko Kogawa
authors.initials: KK
authors.lastname: Sato
authors.forename: Tomoshige
authors.initials: T
authors.lastname: Hayashi
authors.forename: Nobuko
authors.initials: N
authors.lastname: Harita
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoneda
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Ginji
authors.initials: G
authors.lastname: Endo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kambe
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005215:Fasting; D005500:Follow-Up Studies; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin