Use of primary human fetal chondroblast culture for xenotransplantation into rat articular cartilage defect.
The possibility of xenotransplantation of human fetal chondroblasts was studied. Filling of the rat articular cartilage defect with a tissue-engineering construction based on primary culture of human fetal chondroblasts and chitosan gel caused no immune rejection over 60 days and provided the formation of organotypical regenerate due to proliferation and differentiation of donor fetal chondroblasts and their integration in the recipient cartilage tissue.
Sakharov
A V
AV
Laboratory of Morphology, Novosibirsk State Pedagogical University, Moscow, Russia. andrey_sakharov@ngs.ru
Makeyev
A A
AA
Efremov
A V
AV
Valeyeva
V A
VA
Burova
L G
LG
Kolokoltseva
T D
TD
Lukanina
S N
SN
Pykhtina
M B
MB
Ryabchikova
E I
EI
D000818:Animals; D002358:Cartilage, Articular / Q000473:pathology / Q000637:transplantation; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000637:transplantation; D005333:Fetus / Q000166:cytology; D006801:Humans; D051381:Rats; D014183:Transplantation, Heterologous / Q000379:methods*