title: Nanofabricated upconversion nanoparticles for photodynamic therapy.
abstract: We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.
authors.affiliation: Department of Chemical Engineering, Princeton University, Princeton, NJ, USA.
authors.forename: Baris
authors.initials: B
authors.lastname: Ungun
authors.forename: Robert K
authors.initials: RK
authors.lastname: Prud'homme
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Budijon
authors.forename: Jingning
authors.initials: J
authors.lastname: Shan
authors.forename: Shuang F
authors.initials: SF
authors.lastname: Lim
authors.forename: Yiguang
authors.initials: Y
authors.lastname: Ju
authors.forename: Robert
authors.initials: R
authors.lastname: Austin
mesh_terms: D001672:Biocompatible Materials; D006801:Humans; D008027:Light; D008674:Metals, Rare Earth / Q000528:radiation effects; D012157:Mononuclear Phagocyte System / Q000502:physiology* / Q000528:radiation effects; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D010778:Photochemotherapy / Q000295:instrumentation* / Q000379:methods*; D017785:Photons; D017319:Photosensitizing Agents; D011092:Polyethylene Glycols; D011166:Porphyrins; D026082:Singlet Oxygen / Q000032:analysis
chemical_list: D001672:Biocompatible Materials; D008674:Metals, Rare Earth; D017319:Photosensitizing Agents; D011166:Porphyrins; D026082:Singlet Oxygen; D011092:Polyethylene Glycols