Novel genomic methods for drug discovery and mechanism-based toxicological assessment.
Genomics encompasses a range of powerful technologies that can be applied at all levels of gene expression, from transcription to mRNA translation. Collectively, these technologies have great potential for improving drug discovery, both target and molecule recognition, and development. In this article we review the current and potential future status of established and novel genomic methods within drug discovery.
Gant
Timothy W
TW
University of Leicester, Lancaster Road, UK. twg1@le.ac.uk
Zhang
Shu-Dong
SD
Taylor
Emma L
EL
D015195:Drug Design; D004345:Drug Industry / Q000379:methods*; D064420:Drug-Related Side Effects and Adverse Reactions; D020869:Gene Expression Profiling; D023281:Genomics / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis; D014116:Toxicology / Q000379:methods*