[Correlations between the expression of vascular cell adhesion molecule-1 gene and clinical pathological characteristics and angiogenesis in oral squamous cell carcinoma].
OBJECTIVE
To investigate the correlations between the expression of vascular cell adhesion molecule-1 (VCAM-1) gene and clinicopathologic characteristics and microvessel density (MVD) in oral squamous cell carcinoma (OSCC).


METHODS
Expression and location of VCAM-1mRNA and protein in 48 OSCCs and 10 normal controls were detected by in situ hybridization and immunohistochemical stainingìMVD was also assessed. Statistical analysis was performed using SPSS13.0 software package for Student's t test and Chi-square test.


RESULTS
VCAM-1mRNA was mainly detected in cytoplasm of OSCC.VCAM-1 protein was mainly detected in membrane and cytoplasm of OSCC. The expression of VCAM-1mRNA and protein were significantly higher in OSCC tissues than normal oral tissues (P<0.01). In the clinicopathologic factors, lymph node metastasis and depth of infiltration were closely correlated with VCAM-1 expression (P<0.01), but there was no significant correlation between the positively expression and patients' sex, age and tumor' differentiated degree (P>0.05).


CONCLUSIONS
Overexpression of VCAM-1 gene in OSCC may play a potential role in the development of OSCC.It is closely associated with lymph node metastasis and the angiogenesis.
Sun
Le-gang
LG
Department of Oral and Maxillofacial Surgery, the Affiliated Hospital of Binzhou Medical College, Binzhou 256603,Shangdong, China. sunlegang@163.com
Song
Yu-feng
YF
Liu
Ling
L
Yang
You-cheng
YC
Wang
Fang
F
Wang
Li-fang
LF
D002294:Carcinoma, Squamous Cell / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D009062:Mouth Neoplasms / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism*
D019010:Vascular Cell Adhesion Molecule-1