title: Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.
abstract: A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a polyene peroxide with pronounced antifungal activity. Its structure, absolute configuration, and biological activity were determined by spectral analysis, chemical modification followed by the modified Mosher method, and growth inhibitory assays, respectively.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
authors.forename: Jarrod J
authors.initials: JJ
authors.lastname: Scott
authors.forename: Cameron R
authors.initials: CR
authors.lastname: Currie
authors.forename: Jon
authors.initials: J
authors.lastname: Clardy
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001517:Coleoptera / Q000382:microbiology; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028223:Pinus; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000085:Acetates; D000935:Antifungal Agents; D010545:Peroxides; D011090:Polyenes; C532356:mycangimycin