title: Two new flavonol glycosides from Lamium amplexicaule L. and their in vitro free radical scavenging and tyrosinase inhibitory activities.
abstract: Two new flavonol glycosides, kaempferol 3-O-[beta-D-glucopyranosyl-(1-->4)][alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside and quercetin 3-O-[beta-D-glucopyranosyl-(1-->4)][alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside, together with three known flavonoids were isolated using column chromatography from the aerial parts of Lamium amplexicaule (Labiatae). In addition, the five isolates were evaluated for their in vitro free radical scavenging (EC50 values, 14.1-63.9 microg/mL) and tyrosinase inhibitory activities (IC50 values, 110.4-193.5 microg/mL).
authors.affiliation: Department of Pharmaceutical Engineering, Sangji University, Wonju, Korea.
authors.forename: Agung
authors.initials: A
authors.lastname: Nugroho
authors.forename: Jun-Kil
authors.initials: JK
authors.lastname: Choi
authors.forename: Jong-Hee
authors.initials: JH
authors.lastname: Park
authors.forename: Kyung-Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Bae Cheon
authors.initials: BC
authors.lastname: Cha
authors.forename: Hee-Juhn
authors.initials: HJ
authors.lastname: Park
mesh_terms: D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D019259:Lamivudine / Q000737:chemistry*; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*
chemical_list: D047309:Flavones; D016166:Free Radical Scavengers; D006027:Glycosides; D019259:Lamivudine; D014442:Monophenol Monooxygenase