Orthogonal synthesis of isoindole and isoquinoline derivatives from organic azides.
Alpha-azido carbonyl compounds bearing a 2-alkenylaryl moiety at the alpha-position are found to be promising precursors for synthesis of isoindole and isoquinoline derivatives via 1,3-dipolar cycloaddition of azides onto alkenes and 6pi-electrocyclization of N-H imine intermediates, respectively.
Hui
Benjamin Wei-Qiang
BW
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
Chiba
Shunsuke
S