title: Prevention of recurrent radioulnar heterotopic ossification by combined indomethacin and a dermal/silicone sheet implant: case report.
abstract: A 27-year-old, right-handed man developed severe radioulnar synostosis at the distal radius 7 months after open reduction and internal fixation of his distal radius fracture. Heterotopic ossification formed at the radius fracture site, requiring excision of the heterotopic bone and plate removal. A bilayer, dermal substitute and silicone sheet was placed between the radius and ulna in the interosseous space to prevent recurrence of the heterotopic ossification. After surgery, the patient was treated with indomethacin 25 mg orally 3 times daily for 6 weeks. At 1 year after surgery, he has retained full pronation and near normal supination. Radiographs demonstrate no new heterotopic bone formation.
authors.affiliation: Section of Plastic Surgery, Department of Surgery, The University of Michigan Health System, Ann Arbor, MI 48109-5340, USA.
authors.forename: Ian F
authors.initials: IF
authors.lastname: Lytle
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Chung
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002809:Chondroitin Sulfates; D003094:Collagen; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D009999:Ossification, Heterotopic / Q000628:therapy*; D055502:Secondary Prevention; D017768:Skin, Artificial; D013165:Splints; D013580:Synostosis / Q000628:therapy; D014955:Wrist Joint
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen; D007213:Indomethacin