Interleukin-17A and interleukin-17F: a tale of two cytokines.
In this issue of Immunity, Ishigame et al. (2009) show that interleukin-17A (IL-17A) mediates autoimmunity whereas both IL-17A and IL-17F are required for mucosal immunity. IL-17A may be more pathologic by inducing proinflammatory cytokines.
Dubin
Patricia J
PJ
Children's Hospital of Pittsburgh, Rangos Research Center, Pittsburgh, PA 15201, USA.
Kolls
Jay K
JK
D000818:Animals; D015551:Autoimmunity; D006801:Humans; D018928:Immunity, Mucosal; D020381:Interleukin-17 / Q000276:immunology / Q000502:physiology*
D020381:Interleukin-17