title: The untapped potential of genetically engineered mouse models in chemoprevention research: opportunities and challenges.
abstract: The past decade has witnessed the unveiling of a powerful new generation of genetically engineered mouse (GEM) models of human cancer, which are proving to be highly effective for elucidating cancer mechanisms and interrogating novel experimental therapeutics. This new generation of GEM models are well suited for chemoprevention research, particularly for investigating progressive stages of carcinogenesis, identifying biomarkers for early detection and intervention, and preclinical assessment of novel agents or combinations of agents. Here we discuss opportunities and challenges for the application of GEM models in prevention research, as well as strategies to maximize their relevance for human cancer.
authors.affiliation: Department of Urology, Herbert Irving Comprehensive Cancer Center, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. cabateshen@columbia.edu
authors.forename: Cory
authors.initials: C
authors.lastname: Abate-Shen
authors.forename: Powel H
authors.initials: PH
authors.lastname: Brown
authors.forename: Nancy H
authors.initials: NH
authors.lastname: Colburn
authors.forename: Eugene W
authors.initials: EW
authors.lastname: Gerner
authors.forename: Jeffery E
authors.initials: JE
authors.lastname: Green
authors.forename: Martin
authors.initials: M
authors.lastname: Lipkin
authors.forename: William G
authors.initials: WG
authors.lastname: Nelson
authors.forename: David
authors.initials: D
authors.lastname: Threadgill
mesh_terms: D000818:Animals; D018890:Chemoprevention / Q000379:methods*; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods* / Q000639:trends; D004526:Efficiency; D016147:Genes, Tumor Suppressor; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D009369:Neoplasms / Q000235:genetics / Q000517:prevention & control*