title: Low-dose involved-field radiotherapy as alternative treatment of nodular lymphocyte predominance Hodgkin's lymphoma.
abstract: OBJECTIVE
  Nodular lymphocyte predominance Hodgkin's lymphoma is a very rare disease, characterized by an indolent clinical course, with sometimes very late relapses occurring in a minority of all patients. Considerable discussion is ongoing on the treatment of primary and relapsed disease.
  
  
  METHODS
  A group of 9 patients were irradiated to a dose of 4 Gy on involved areas only.
  
  
  RESULTS
  After a median follow-up of 37 months (range, 6-66), the overall response rate was 89%. Six patients had complete remission (67%), two had partial remission (22%), and one had stable disease (11%). Of 8 patients, 5 developed local relapse 9-57 months after radiotherapy. No toxicity was noted.
  
  
  CONCLUSIONS
  In nodular lymphocyte predominance Hodgkin's lymphoma, low-dose radiotherapy provided excellent response rates and lasting remissions without significant toxicity.
authors.affiliation: Department of Radiotherapy, The Netherlands Cancer Institute Amsterdam, Amsterdam, The Netherlands. r.haas@nki.nl
authors.forename: Rick L M
authors.initials: RL
authors.lastname: Haas
authors.forename: Theo
authors.initials: T
authors.lastname: Girinsky
authors.forename: Berthe M P
authors.initials: BM
authors.lastname: Aleman
authors.forename: Michel
authors.initials: M
authors.lastname: Henry-Amar
authors.forename: Jan-Paul
authors.initials: JP
authors.lastname: de Boer
authors.forename: Daphne
authors.initials: D
authors.lastname: de Jong
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012008:Recurrence; D012074:Remission Induction; D055815:Young Adult