title: Antimicrobial activity of commercial Olea europaea (olive) leaf extract.
abstract: The aim of this research was to investigate the activity of a commercial extract derived from the leaves of Olea europaea (olive) against a wide range of microorganisms (n=122). Using agar dilution and broth microdilution techniques, olive leaf extract was found to be most active against Campylobacter jejuni, Helicobacter pylori and Staphylococcus aureus [including meticillin-resistant S. aureus (MRSA)], with minimum inhibitory concentrations (MICs) as low as 0.31-0.78% (v/v). In contrast, the extract showed little activity against all other test organisms (n=79), with MICs for most ranging from 6.25% to 50% (v/v). In conclusion, olive leaf extract was not broad-spectrum in action, showing appreciable activity only against H. pylori, C. jejuni, S. aureus and MRSA. Given this specific activity, olive leaf extract may have a role in regulating the composition of the gastric flora by selectively reducing levels of H. pylori and C. jejuni.
authors.affiliation: Discipline of Microbiology and Immunology, School of Biomedical, Biomolecular and Chemical Sciences, The University of Western Australia, 35 Stirling Hwy, Crawley, WA 6009, Australia.
authors.forename: Aurelia N
authors.initials: AN
authors.lastname: Sudjana
authors.forename: Carla
authors.initials: C
authors.lastname: D'Orazio
authors.forename: Vanessa
authors.initials: V
authors.lastname: Ryan
authors.forename: Nooshin
authors.initials: N
authors.lastname: Rasool
authors.forename: Justin
authors.initials: J
authors.lastname: Ng
authors.forename: Nabilah
authors.initials: N
authors.lastname: Islam
authors.forename: Thomas V
authors.initials: TV
authors.lastname: Riley
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Hammer
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D016123:Campylobacter jejuni / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D031658:Olea / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts