Eosinophilic oesophagitis: clinical manifestations and treatment options. The role of the allergologist.
Eosinophilic oesophagitis (EO) is an infrequent disorder that is currently underdiagnosed. It has been described in both adults and in children, and is more prevalent among males. The etiology of EO is not clear, though atopy has been suggested as playing an important role in the development of the disease. The clinical presentation of EO is varied, and a differential diagnosis with other digestive tract disorders is required particularly gastro-oesophageal re-flux. Dysphagia and food bolus impactation within the oesophagus are the most characteristic symptoms. Diagnostic confirmation is obtained from multiple oesophageal biopsy, with the detection in some sample or samples of over 15 eosinophils per high-magnification microscopic field. An allergological study is needed to evaluate the existence of allergens (perennial or seasonal environmental allergens and food allergens) responsible for the eosinophilic infiltration found at oesophageal level. There is no specific treatment for EO, and topical corticosteroids (swallowed) are currently the pharmacological treatment of choice. Dietary therapy in children with food allergy as the causal factor may prove effective, though the existence of polysensitisation complicates the correct implementation of such treatment. Oesophageal dilatation is reserved for cases with severe dysphagia, and is not without complications. Treatment with anti-IL-5, antileukotrienes, azathioprine, 6-mercaptopurine, anti-IgE, etc., could constitute alternatives to topical corticosteroids, although information is still lacking on their long-term safety and efficacy in the paediatric population.
Ferré-Ybarz
L
L
Althaia, Xarxa Assistencial de Manresa, Sección de Alergia, Servicio de Pediatría, Hospital Sant Joan de Déu de Manresa (Barcelona), Spain. lferre@althaia.cat
Nevot Falcó
S
S
Plaza-Martín
A M
AM
D000818:Animals; D004804:Eosinophils / Q000276:immunology*; D004941:Esophagitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D004947:Esophagus / Q000276:immunology; D005512:Food Hypersensitivity / Q000150:complications / Q000276:immunology; D006801:Humans