Antibiotic delivery polyurethanes containing albumin and polyallylamine nanoparticles.
Nano-structured polymers delivering an antibiotic for the prevention of medical device-related infections were developed. Systems consisted of bovine serum albumin or polyallylamine nanoparticles alone or entrapped in a polyurethane and then loaded with cefamandole nafate, chosen as a drug model. Results showed that nanoparticles alone were able to adsorb high antibiotic amounts due to their high surface/volume ratio. However, they released cefamandole in an uncontrolled fashion, leading to a rapid loss of antibacterial activity. Improvements in the release control were obtained when CEF loaded and non-loaded nanoparticles were entrapped in a carboxylated polyurethane. For these systems the drug delivery was at least of 50% with respect to nanoparticles alone with a prolonged antimicrobial activity up to 9 days.
Crisante
Fernanda
F
Department of Chemistry, "Sapienza" University of Rome P.le A. Moro 5, 00185 Rome, Italy.
Francolini
Iolanda
I
Bellusci
Mariangela
M
Martinelli
Andrea
A
D'Ilario
Lucio
L
Piozzi
Antonella
A
D000327:Adsorption; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D002435:Cefamandole / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D011073:Polyamines / Q000737:chemistry*; D011140:Polyurethanes / Q000008:administration & dosage* / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D011073:Polyamines; D011140:Polyurethanes; D012710:Serum Albumin, Bovine; C063994:polyallylamine; D002435:Cefamandole