title: SREBPs: physiology and pathophysiology of the SREBP family.
abstract: Sterol regulatory element-binding proteins (SREBPs) have been established as physiological regulators of lipid synthesis. The molecular mechanisms by which cellular sterol balance and nutritional states regulate SREBP activities are the current research focus of this field. Meanwhile, it has been shown that overnutrition or disturbed energy balance causes accumulation of tissue lipids, leading to metabolic disorders, often referred to as 'lipotoxicity'. In this overview, I discuss the pathological aspects of SREBPs, which contribute to lipotoxicity in a wide variety of organs, including hepatic insulin resistance in hepatosteatosis, impaired insulin secretion in pancreatic beta-cells, diabetic nephropathy, cardiac arrythmiasis, and obesity.
authors.affiliation: Department of Internal Medicine (Endocrinoglogy and Metabolism), Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan. shimano-tky@umin.ac.jp
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimano
mesh_terms: D000818:Animals; D004194:Disease; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism; D009928:Organ Specificity; D051779:Sterol Regulatory Element Binding Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D013261:Sterols / Q000378:metabolism
chemical_list: D051779:Sterol Regulatory Element Binding Proteins; D013261:Sterols