Sonic hedgehog and CDX2 expression in the stomach.
Sonic hedgehog (Shh) is an essential regulator of patterning processes throughout development, and CDX proteins act as the master regulators for intestinal development and differentiation. Shh and CDX2 seem to be interdependently linked with cellular differentiation through different signal cascades. We have recently shown that the loss of Shh and aberrant expression of CDX2 in Helicobacter pylori (H. pylori)-associated atrophic gastritis can be modified by H. pylori eradication prior to incomplete intestinal metaplasia. On the other hand, abnormal signaling of the hedgehog pathway has been reported in gastric cancer, especially diffuse-type cancer and advanced gastric cancer, and Shh acts as a proliferation factor in both the normal mucosa and malignant lesions. CDX2 expressed in the early stage of gastric carcinogenesis is associated with the intestinal phenotypic region and thus with a better outcome. However, it remains unclear how Shh and CDX2 are involved with intestinal transformation and further carcinogenesis.
Shiotani
Akiko
A
Department of Internal Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan. shiotani@med.kawasaki-m.ac.jp
Kamada
Tomoari
T
Yamanaka
Yoshiyuki
Y
Manabe
Noriaki
N
Kusunoki
Hiroaki
H
Hata
Jiro
J
Haruma
Ken
K
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000071616:CDX2 Transcription Factor; D002454:Cell Differentiation; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D005753:Gastric Mucosa / Q000378:metabolism*; D005757:Gastritis, Atrophic / Q000378:metabolism / Q000382:microbiology; D053823:Hedgehog Proteins / Q000378:metabolism*; D016481:Helicobacter Infections / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology; D018398:Homeodomain Proteins / Q000378:metabolism*; D006801:Humans; D012307:Risk Factors; D015398:Signal Transduction; D013270:Stomach / Q000187:drug effects / Q000382:microbiology / Q000473:pathology; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control
D000900:Anti-Bacterial Agents; D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; C509239:SHH protein, human