title: Capillary rarefaction in treated and untreated hypertensive subjects.
abstract: This study aimed to determine if capillary rarefaction is detectable and associated with endothelial dysfunction in persons with mild systolic blood pressure (SBP) elevation. Capillary density and endothelial function were quantified for 150 nondiabetic participants, grouped by blood pressure (BP) as normotensive, untreated high BP, and treated high BP. Structural capillary rarefaction measures were not different between the three groups. Functional capillary rarefaction measures were significantly lower in both high BP groups compared to normotensives, and correlated inversely with endothelial function. The study findings indicate that the hypertensive vascular pathologic process is already underway at modest levels of blood pressure elevation.
authors.affiliation: Department of Family and Community Medicine, Thomas Jefferson University Hospital, Curtis Bldg, Suite 401, 1015 Walnut Street, Philadelphia, PA 19107, USA. Cynthia.Cheng@ jefferson.edu
authors.forename: Cynthia
authors.initials: C
authors.lastname: Cheng
authors.forename: Constantine
authors.initials: C
authors.lastname: Daskalakis
authors.forename: Bonita
authors.initials: B
authors.lastname: Falkner
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044466:Asian People; D044383:Black People; D001794:Blood Pressure; D002196:Capillaries / Q000473:pathology* / Q000502:physiology; D004730:Endothelium, Vascular / Q000502:physiology; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000208:ethnology / Q000473:pathology*; D016014:Linear Models; D008297:Male; D018715:Microscopy, Video; D008875:Middle Aged; D009262:Nails / Q000098:blood supply; D010991:Plethysmography; D012039:Regional Blood Flow; D012307:Risk Factors; D044465:White People
chemical_list: D000959:Antihypertensive Agents