title: Novel antibacterial and emollient effects of coconut and virgin olive oils in adult atopic dermatitis.
abstract: BACKGROUND
  Atopic dermatitis (AD) skin is dry and readily colonized by Staphylococcus aureus (SA). Coconut and olive oils are traditionally used to moisturize and treat skin infections.
  
  
  OBJECTIVE
  To compare virgin coconut oil (VCO) and virgin olive oil (VOO) in moisturizing dryness and removing SA from colonized AD skin.
  
  
  METHODS
  This was a double-blind controlled trial in two outpatient dermatology clinics with adult AD patients who were diagnosed by history, pattern, evolution, and skin lesions and who were randomized to apply VCO or VOO twice daily at two noninfected sites. SA cultures, photography, and objective-SCORAD severity index (O-SSI) scoring were done at baseline and after 4 weeks.
  
  
  RESULTS
  Twenty-six subjects each received VCO or VOO. Of those on VCO, 20 were positive for SA colonies at baseline versus 12 on VOO. Post intervention, only 1 (5%) VCO subject remained positive versus 6 (50%) of those on VOO. Relative risk for VCO was 0.10, significantly superior to that for VOO (10:1, p = .0028; 95% CI, 0.01-0.73); thus, the number needed to treat was 2.2. For the O-SSI, the difference was not significant at baseline (p = .15) but was significantly different post treatment (p = .004); this was reduced for both oils (p < .005) but was greater with VCO.
  
  
  CONCLUSIONS
  VCO and monolaurin's O-SSI reduction and in vitro broad-spectrum activity against SA (given clinical validity here), fungi, and viruses may be useful in the proactive treatment of AD colonization.
authors.affiliation: Skin and Cancer Foundation, Pasig, Philippines. vmvrmd@gmail.com
authors.forename: Vermén M
authors.initials: VM
authors.lastname: Verallo-Rowell
authors.forename: Kristine M
authors.initials: KM
authors.lastname: Dillague
authors.forename: Bertha S
authors.initials: BS
authors.lastname: Syah-Tjundawan
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003059:Cocos; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D004311:Double-Blind Method; D004643:Emollients / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage*; D013207:Staphylococcal Skin Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus
chemical_list: D000900:Anti-Bacterial Agents; D004643:Emollients; D000069463:Olive Oil; D010938:Plant Oils