title: Comparison of prognosis for men with type 2 diabetes mellitus and men with cardiovascular disease.
abstract: BACKGROUND
  People with type 2 diabetes mellitus are at high risk for cardiovascular disease. In some studies, the mortality rate among people with this condition has been equivalent to that among people with cardiovascular disease. We compared cardiovascular mortality between incident cases of diabetes and cardiovascular disease.
  
  
  METHODS
  The study population was part of a random sample of 4376 men from Quebec, Canada, aged 35 to 64 years, who did not have cardiovascular disease in 1974 and who were followed until 1998. Three groups of incident cases were identified: diabetes without cardiovascular disease, first cardiovascular event (myocardial infarction, unstable angina or stroke) without diabetes, and both cardiovascular disease and diabetes. These cases were age-matched to a control group without diabetes or cardiovascular disease.
  
  
  RESULTS
  During the 24-year follow-up period, new diabetes without cardiovascular disease was documented in 137 men. A first cardiovascular event without diabetes was documented in 527 men. Relative to the 627 controls, men with 1 of the 2 diseases of interest had higher cardiovascular mortality (age-adjusted relative risk [RR] 3.11, 95% confidence interval [CI] 1.96-4.92) for those with diabetes and 4.46 (95% CI 3.15-6.30) for those with cardiovascular disease). However, within the first 5 years after diagnosis, men with cardiovascular disease had higher cardiovascular mortality than men with diabetes (age-adjusted RR 2.03, 95% CI 1.01-4.08).
  
  
  CONCLUSIONS
  Men with isolated type 2 diabetes and men with isolated cardiovascular disease had similar cardiovascular mortality rates several years after initial diagnosis of either condition. These findings reinforce the need to prevent and optimally manage diabetes and cardiovascular disease.
authors.affiliation: Institut universitaire de cardiologie et pneumologie, Montréal, Que. gilles.dagenais@crhl.ulaval.ca
authors.forename: Gilles R
authors.initials: GR
authors.lastname: Dagenais
authors.forename: Annie
authors.initials: A
authors.lastname: St-Pierre
authors.forename: Patrick
authors.initials: P
authors.lastname: Gilbert
authors.forename: Benoît
authors.initials: B
authors.lastname: Lamarche
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Després
authors.forename: Paul-Marie
authors.initials: PM
authors.lastname: Bernard
authors.forename: Peter
authors.initials: P
authors.lastname: Bogaty
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000401:mortality*; D003924:Diabetes Mellitus, Type 2 / Q000401:mortality*; D003925:Diabetic Angiopathies / Q000401:mortality*; D004562:Electrocardiography; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000401:mortality; D011379:Prognosis; D011792:Quebec / Q000453:epidemiology