title: Integrated fluidic systems on a nanometer scale and the study on behavior of liquids in small confinement.
abstract: Nanofluidic systems and the studies on the behavior of liquids confined in nanometer-sized space are reviewed. Miniaturized chemical systems having nanometer-sized structures are fabricated by using advanced nanofabrication techniques. The size-confinement effect is expected to be applied in well-controlled chemical and biochemical analysis. While electroosmosis and electrokinetic migration in small-sized channels have been investigated extensively, there have been few reports on pressure-driven flow systems having nanometer-sized structures, which are widely used in laboratory-scale and micrometer-sized systems. In this review, fundamental technologies that can be used in integrated chemical analysis systems having nanometer-sized structures are introduced. In addition to the technological investigations, important topics in the fundamental research on the properties of liquids confined in nanometer-sized space are also presented.
authors.affiliation: Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan. hibara@iis.u-tokyo.ac.jp
authors.forename: Akihide
authors.initials: A
authors.lastname: Hibara
authors.forename: Takehiko
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kitamori
mesh_terms: D008832:Microchemistry / Q000191:economics / Q000295:instrumentation; D046210:Microfluidic Analytical Techniques / Q000191:economics / Q000295:instrumentation; D044085:Microfluidics / Q000191:economics / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation; D011312:Pressure