Evolution of the Sabin vaccine into pathogenic derivatives without appreciable changes in antigenic properties: need for improvement of current poliovirus surveillance.
The Sabin oral polio vaccine (OPV) may evolve into pathogenic viruses, causing sporadic cases and outbreaks of poliomyelitis. Such vaccine-derived polioviruses (VDPV) generally exhibit altered antigenicity. The current paradigm to distinguish VDPV from OPV and wild polioviruses is to characterize primarily those poliovirus isolates that demonstrate deviations from OPV in antigenic and genetic intratypic differentiation (ITD) tests. Here we report on two independent cases of poliomyelitis caused by VDPVs with "Sabin-like" properties in several ITD assays. The results suggest the existence of diverse pathways of OPV evolution and necessitate improvement of poliovirus surveillance, which currently potentially misses this class of VDPV.
Yakovenko
Maria L
ML
M. V. Lomonosov Moscow State University, Moscow 119899, Russia.
Korotkova
Ekaterina A
EA
Ivanova
Olga E
OE
Eremeeva
Tatyana P
TP
Samoilovich
Elena
E
Uhova
Iryna
I
Gavrilin
Gene V
GV
Agol
Vadim I
VI
D002675:Child, Preschool; D019143:Evolution, Molecular; D006801:Humans; D007223:Infant; D008297:Male; D008958:Models, Molecular; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D009690:Nucleic Acid Conformation; D017354:Point Mutation; D011051:Poliomyelitis / Q000821:virology*; D017955:Poliovirus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects* / Q000276:immunology*; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D014774:Virulence
D011055:Poliovirus Vaccine, Oral; D012367:RNA, Viral