title: Prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography pancreatitis: a randomized placebo-controlled trial.
abstract: OBJECTIVE
  To examine the prophylactic effect of glyceryl trinitrate on post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis and hyperamylasemia.
  
  
  METHODS
  Patients scheduled for ERCP were randomly divided into study group and placebo group. Patients in study group and placebo group were treated with 5 mg glyceryl trinitrate and 100 mg vitamin C, respectively, 5 min before endoscopic maneuvers.
  
  
  RESULTS
  A total of 74 patients were enrolled in the final analysis. Post-ERCP pancreatitis occurred in 3 patients (7.9%) of the study group and 9 patients (25%) in the placebo group (P = 0.012). Hyperamylasemia occurred in 8 patients of the study group (21.1%) and 13 patients (36.1%) of the placebo group (P = 0.037).
  
  
  CONCLUSIONS
  Glyceryl trinitrate before ERCP can effectively prevent post-ERCP and hyperamylasemia.
authors.affiliation: Department of Digestion, Beijing Chaoyang Hospital Affiliated to Capital Medical University, China. ylxyyn@hotmail.com
authors.forename: Jian Yu
authors.initials: JY
authors.lastname: Hao
authors.forename: Dong Fang
authors.initials: DF
authors.lastname: Wu
authors.forename: Yue Zeng
authors.initials: YZ
authors.lastname: Wang
authors.forename: Ying Xin
authors.initials: YX
authors.lastname: Gao
authors.forename: Hai Po
authors.initials: HP
authors.lastname: Lang
authors.forename: Wei Zhen
authors.initials: WZ
authors.lastname: Zhou
mesh_terms: D000328:Adult; D000368:Aged; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects*; D005260:Female; D006801:Humans; D034321:Hyperamylasemia / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use*; D010195:Pancreatitis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*; D010919:Placebos; D016896:Treatment Outcome
chemical_list: D010919:Placebos; D005996:Nitroglycerin