title: Bone graft substitutes in anterior cervical discectomy and fusion.
abstract: Anterior cervical discectomy with fusion is a common surgical procedure for patients suffering pain and/or neurological deficits and unresponsive to conservative management. For decades, autologous bone grafted from the iliac crest has been used as a substrate for cervical arthrodesis. However patient dissatisfaction with donor site morbidity has led to the search for alternative techniques. We present a literature review examining the progress of available grafting options as assessed in human clinical trials, considering allograft-based, synthetic, factor- and cell-based technologies.
authors.affiliation: University of New South Wales, Sydney, Australia.
authors.forename: Anthony M T
authors.initials: AM
authors.lastname: Chau
authors.forename: Ralph J
authors.initials: RJ
authors.lastname: Mobbs
mesh_terms: D016025:Bone Transplantation / Q000009:adverse effects / Q000379:methods*; D002574:Cervical Vertebrae / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D017586:Diskectomy / Q000379:methods*; D006801:Humans; D007403:Intervertebral Disc / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D011183:Postoperative Complications / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D019736:Prostheses and Implants / Q000009:adverse effects / Q000639:trends*; D013123:Spinal Fusion / Q000379:methods*; D014184:Transplantation, Homologous / Q000379:methods* / Q000639:trends