title: Application of silicon nanowires and indium tin oxide surfaces in desorption electrospray ionization.
abstract: Two nanostructured surfaces are introduced as advantageous substrates for desorption electrospray ionization mass spectrometry (DESI-MS). Nano-assisted laser desorption/ionization (NALDI) plates coated with silicon nanowires (SiNWs) and indium tin oxide (ITO) layers on glass are both conductive non-polar surfaces that were originally designed as superior substrates for matrix-free laser desorption/ionization. In this study, NALDI/SiNWs and ITO were tested as potentially useful DESI substrates for selected model analytes (cyclosporine, beauverolide, surfactin and nystatin). Both nanostructured surfaces produced more intense and longer-lasting signals than other tested surfaces (polytetrafluoroethylene, glass, polymethylmethacrylate and chromatography paper).
authors.affiliation: Laboratory of Molecular Structure Characterization, Institute of Microbiology, Academy of Sciences of the Czech Republic. jaroslav.pol@helsinki.fi
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Pól
authors.forename: Petr
authors.initials: P
authors.lastname: Novák
authors.forename: Michael
authors.initials: M
authors.lastname: Volný
authors.forename: Gary H
authors.initials: GH
authors.lastname: Kruppa
authors.forename: Risto
authors.initials: R
authors.lastname: Kostiainen
authors.forename: Karel
authors.initials: K
authors.lastname: Lemr
authors.forename: Vladimír
authors.initials: V
authors.lastname: Havlícek
mesh_terms: D016572:Cyclosporine / Q000737:chemistry; D049329:Nanostructures; D053770:Nanowires; D015203:Reproducibility of Results; D012825:Silicon / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013499:Surface Properties; D017971:Tin Compounds / Q000737:chemistry*; D035501:Uncertainty
chemical_list: D017971:Tin Compounds; C109984:indium tin oxide; D016572:Cyclosporine; D012825:Silicon