title: Middle cerebral artery occlusion 25 years after cranial radiation therapy in acromegaly: a case report.
abstract: We report a case of ischemic stroke in a 43 year-old woman with no traditional cardiovascular risk factors and a history of cranial surgery and cranial radiation therapy (CRT) for a GH-secreting pituitary macroadenoma. The neurological work-up on this patient disclosed several cerebral ischemic lesions and demonstrated the occlusion of the right middle cerebral artery together with the narrowing of the right carotid artery; post-radiation brain damage was also visible by nuclear magnetic resonance. We postulate the existence in this patient of a radiation-induced vascular damage, which is a well recognized process thoroughly described in in vitro studies. We remark that life-long follow-up of acromegalic patients receiving CRT is essential so that early diagnosis of radiation-induced vascular injury can be made.
authors.affiliation: Department of Medical and Surgical Sciences-3rd Internal Medicine, Padua University, Padua, Italy. pietromaffei@libero.it
authors.forename: P
authors.initials: P
authors.lastname: Maffei
authors.forename: I
authors.initials: I
authors.lastname: Albano
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: M
authors.initials: M
authors.lastname: Barban
authors.forename: R
authors.initials: R
authors.lastname: Manara
authors.forename: G
authors.initials: G
authors.lastname: Meneghetti
authors.forename: N
authors.initials: N
authors.lastname: Sicolo
mesh_terms: D000172:Acromegaly / Q000150:complications* / Q000532:radiotherapy; D000328:Adult; D005260:Female; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000209:etiology*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000150:complications / Q000532:radiotherapy; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects*