Urinary cysteinyl leukotriene E(4) is associated with increased risk for pain and acute chest syndrome in adults with sickle cell disease.
Leukotriene E(4) (LTE(4)) levels are associated with rate of pain episodes in children with sickle cell disease (SCD). Because complications of SCD manifest differently in adults than children, we examined a cohort of adults with SCD to determine the relationship between baseline LTE(4) and SCD-related morbidity. Baseline LTE(4) levels were associated with increased rates of pain and acute chest syndrome (ACS) episodes, when those with LTE(4) values in the highest tertile were compared with those in the lowest tertile (pain: risk ratio 7.1, 95% CI 1.8-27.5, P = 0.005; ACS: risk ratio 12.2, 95% CI 2.1-69.8, P = 0.005).
Field
Joshua J
JJ
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA. jfield@dom.wustl.edu
Krings
James
J
White
Nicole L
NL
Yan
Yan
Y
Blinder
Morey A
MA
Strunk
Robert C
RC
Debaun
Michael R
MR
D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000652:urine*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017999:Leukotriene E4 / Q000652:urine*; D008297:Male; D010146:Pain / Q000150:complications / Q000652:urine*; D014652:Vascular Diseases / Q000150:complications / Q000652:urine; D055815:Young Adult
D017999:Leukotriene E4