MUC1 568 A/G genotype-dependent cancer antigen 15-3 levels in breast cancer patients.
OBJECTIVE
CA 15-3 is a widely used tumor marker for breast cancer. We have investigated whether the MUC1 568 A/G polymorphism can influence CA 15-3 levels in healthy women and patients with breast tumors.


METHODS
CA 15-3 was measured in 208 healthy women, in 67 with benign disease, and in 162 women with breast cancer. All subjects were genotyped for the MUC1 568 A/G polymorphism.


RESULTS
Significant differences were observed between mean CA 15-3 levels of control subjects grouped according to the MUC1 568 genotype (mean+/-SD): AA (10.3+/-3.8), AG (15.9+/-5.0) and GG (19.0+/-5.6) U/mL, p<0.0001. Similar (median) results were observed in women with benign breast disease: AA (10.2), AG (14.2) and GG (16.6) U/mL, p<0.0001, and those with breast cancer: AA (10.4), AG (17.1) and GG (23.9) U/mL, p<0.0001.


CONCLUSIONS
The MUC1 568 A/G polymorphism strongly influences CA 15-3 levels in healthy women and women with either benign or malignant breast tumors.
Kruit
Adrian
A
Department of Clinical Chemistry, St Antonius Hospital, Nieuwegein, The Netherlands.
Tilanus-Linthorst
Madeleine M
MM
Boonstra
Joke G
JG
van Schaik
Ron H N
RH
Grutters
Jan C
JC
van den Bosch
Jules M M
JM
Ruven
Henk J T
HJ
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007118:Immunoassay; D008875:Middle Aged; D018396:Mucin-1 / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D018396:Mucin-1