title: Malaria in São Tomé and principe: on the brink of elimination after three years of effective antimalarial measures.
abstract: In 2005, São Tomé e Príncipe began an initiative aimed at reducing malaria-related mortality to zero. The program included mass coverage with two antivector intervention methods (indoor residual spraying and long-lasting insecticidal nets), artemisinin-based combination therapy, and intermittent preventive therapy in pregnancy with sulfadoxine-pyrimethamine. At the end of 2007, three years after intensified interventions began, malaria-attributed outpatient consultations, hospitalizations, and deaths decreased by more than 85%, 80%, and 95%, respectively, in all age groups. Mean prevalence of parasitemia and splenomegaly were also significantly reduced to 2.1% (P < 0.0001) and 0.3% (P < 0.0001) after two rounds of spraying from baseline prevalences of 30.5% and 48.8%, respectively. The dramatic reduction in malaria morbidity and mortality now enable serious consideration of new goals and strategies aimed at completely interrupting malaria transmission on these islands. We report evidence of the program's impact and the feasibility of and potential strategies for eliminating malaria from São Tomé e Príncipe.
authors.affiliation: Earth Institute at Columbia University, New York, New York, USA. hailaycnhde@ethionet.et
authors.forename: Hailay Desta
authors.initials: HD
authors.lastname: Teklehaimanot
authors.forename: Awash
authors.initials: A
authors.lastname: Teklehaimanot
authors.forename: Anthony
authors.initials: A
authors.lastname: Kiszewski
authors.forename: Herodes Sacramento
authors.initials: HS
authors.lastname: Rampao
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Sachs
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D001266:Atlantic Islands / Q000453:epidemiology; D001769:Blood / Q000469:parasitology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007306:Insecticides; D008288:Malaria / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control*; D018512:Parasitemia / Q000453:epidemiology / Q000517:prevention & control; D011247:Pregnancy; D011248:Pregnancy Complications / Q000469:parasitology; D015995:Prevalence
chemical_list: D000962:Antimalarials; D007306:Insecticides