Mechanisms and treatment of anorexia in end-stage renal disease patients on hemodialysis.
Anorexia, defined as the loss of the desire to eat, is relatively common in hemodialysis patients, occurring in one third of such cases. The pathogenesis is essentially unknown. It has been proposed that uremic toxins such as middle molecules, inflammation, altered amino acid pattern, leptin, ghrelin, and neuropeptide Y are involved. Anorexia reduces oral energy and protein intakes, thus contributing to the development of malnutrition and cachexia. Unquestionably, it contributes to poor quality of life. The clinical relevance of anorexia as an independent prognostic factor in hemodialysis is debated. The treatment of this debilitating condition is based on a therapeutic strategy that may include daily dialysis sessions and nutritional counseling. Normalization of plasma branched chain amino acids through branched chain amino acid supplementation may decrease anorexia and improve energy and protein intake. The role of megestrol acetate as an appetite stimulant needs to be validated through adequate randomized trials. Subcutaneous ghrelin administration and melanocortin-receptor antagonists appear to be promising therapeutic interventions.
Bossola
Maurizio
M
Istituto di Clinica Chirurgica, Università Cattolica del Sacro Cuore, Roma, Italia. maubosso@tin.it
Tazza
Luigi
L
Luciani
Giovanna
G
D000597:Amino Acids, Branched-Chain / Q000502:physiology* / Q000627:therapeutic use; D000855:Anorexia / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology* / Q000517:prevention & control; D004044:Dietary Proteins / Q000008:administration & dosage; D002149:Energy Intake / Q000502:physiology; D054439:Ghrelin / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy*; D009752:Nutritional Status; D011379:Prognosis; D011788:Quality of Life; D044101:Receptors, Melanocortin / Q000037:antagonists & inhibitors; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods
D000597:Amino Acids, Branched-Chain; D004044:Dietary Proteins; D054439:Ghrelin; D044101:Receptors, Melanocortin