Prenatal risk factors for cutaneous malignant melanoma: follow-up of 2,594,783 Danes born from 1950 to 2002.
The incidence of cutaneous malignant melanoma has increased in young adults, specifically in Denmark. In this study, we examined the risk of cutaneous malignant melanoma in relation to prenatal markers of hormone levels and to family-related risk factors. The study was based on a follow-up of 2,594,783 Danes born from 1950 to 2002. Occurrence of possible hormone-related cancers among family members and indicators of abnormal prenatal hormone levels were not associated with cutaneous malignant melanoma risk, whereas family size and mother's age at first birth were significant risk factors for cutaneous malignant melanoma in offspring.
Olesen
Anne Vingaard
AV
Department of Epidemiology, University of Aarhus, Denmark. acvo@rn.dk
Parner
Erik Thorlund
ET
Mortensen
Preben Bo
PB
Sørensen
Henrik Toft
HT
Olsen
Jørn
J
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D003718:Denmark / Q000453:epidemiology; D005191:Family Characteristics; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008423:Maternal Age; D008545:Melanoma / Q000453:epidemiology* / Q000235:genetics; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015995:Prevalence; D012042:Registries; D012307:Risk Factors; D012737:Sex Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000235:genetics