title: Fibrolamellar hepatocellular carcinoma in an infant and literature review.
abstract: Hepatocellular carcinoma (HCC) is a rare pediatric neoplasm exceptionally reported in infants and fibrolamellar hepatocarcinoma (FLC) a HCC variant. Controversy exists whether FLC has a better prognosis than classic HCC, although recent studies of children and young adults with FLC did not report a better outcome. We present a 4-month-old male infant without any related metabolic or infectious disease who developed a metastatic and multifocal FLC. Serum alpha-fetoprotein determinations were always normal. Induction chemotherapy using cisplatin and Adriamycin resulted in a partial response, however, refractory disease developed and regional metastasis precluded surgical resection. The child died from tumoral progression.
authors.affiliation: Department of Oncology, Hospital San Joan de Déu, Universidad de Barcelona, Spain. ocruz@hsjdbcn.org
authors.forename: Ofelia
authors.initials: O
authors.lastname: Cruz
authors.forename: Astrid
authors.initials: A
authors.lastname: Laguna
authors.forename: Margarita
authors.initials: M
authors.lastname: Vancells
authors.forename: Lucas
authors.initials: L
authors.lastname: Krauel
authors.forename: Marilyn
authors.initials: M
authors.lastname: Medina
authors.forename: Jaume
authors.initials: J
authors.lastname: Mora
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D017809:Fatal Outcome; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins; D004317:Doxorubicin; D002945:Cisplatin