Association of eosinophilic gastrointestinal disorders with other atopic disorders.
Eosinophilic esophagitis is a chronic disease that leads to either persistent symptoms or, at times, intermittent "flares." It shares many features with other atopic diseases (asthma, allergic rhinitis, and atopic dermatitis), including the following: T helper 2 cells and eosinophils play a critical role in the pathogenesis of the disease; avoidance of allergens promotes remission of disease and symptom control; and locally applied corticosteroids provide control. Finally, most patients who have eosinophilic gastrointestinal disorders have an associated atopic disease.
Jyonouchi
Soma
S
Division of Allergy and Immunology, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
Brown-Whitehorn
Terri A
TA
Spergel
Jonathan M
JM
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000485:Allergens / Q000276:immunology; D000818:Animals; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism; D004802:Eosinophilia / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004941:Esophagitis / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D000305:Adrenal Cortex Hormones; D000485:Allergens; D016207:Cytokines