Prenatal infection and cavum septum pellucidum in adult schizophrenia.
Increased length of the cavum septum pellucidum (CSP) and in utero infection are each associated with increased risk of schizophrenia. Hence, we examined whether prenatal infections are related to CSP length in schizophrenia patients. In a well-characterized birth cohort, in utero infection was assessed using serologic biomarkers or physician diagnoses. Magnetic resonance images were acquired, and CSP length was quantified by a standard protocol. In utero infection was associated with increased CSP length in exposed schizophrenia cases compared to unexposed cases, suggesting that prenatal infection plays a role in a neurodevelopmental morphologic anomaly that has been related previously to schizophrenia.
Brown
Alan S
AS
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York State Psychiatric Institute, Mailman School of Public Health, 1051 Riverside Drive, Unit 23, New York, NY 10032, USA. asb11@columbia.edu
Deicken
Raymond F
RF
Vinogradov
Sophia
S
Kremen
William S
WS
Poole
John H
JH
Penner
Justin D
JD
Kochetkova
Anna
A
Kern
David
D
Schaefer
Catherine A
CA
D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000145:classification; D012559:Schizophrenia / Q000209:etiology* / Q000473:pathology*; D012688:Septum Pellucidum / Q000002:abnormalities*