title: Prognostic significance of left atrial volume dilatation in patients with hypertrophic cardiomyopathy.
abstract: To evaluate the prognostic role of left atrial (LA) volume in hypertrophic cardiomyopathy (HCM), LA volume was measured at baseline and during follow-up in 140 patients with HCM. Unfavorable outcome, defined as occurrence of sudden death, heart transplantation, or invasive reduction of obstruction, developed in 16 patients. In patients with enlarged LA volume (>27 mL/m(2)), there was an increased risk for unfavorable outcome (P = .0152). Patients with normal LA volume at baseline in whom volume increased more than 3 mL per year (fast dilating LA volume) had a worse prognosis than patients with normal and stable volume (P < .001) and similar to patients with dilated LA volume at baseline (P = not significant). LA volume dilated at baseline, fast dilating LA volume, and New York Heart Association functional class were independent predictors of unfavorable outcome development (odds ratio: 11.453; P = .021, P = 2.019, P = .020, respectively). The assessment of LA volume at baseline and during follow-up adds information regarding prognosis in patients with HCM.
authors.affiliation: Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University School of Medicine, Naples, Italy.
authors.forename: Maria-Angela
authors.initials: MA
authors.lastname: Losi
authors.forename: Sandro
authors.initials: S
authors.lastname: Betocchi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Barbati
authors.forename: Valentina
authors.initials: V
authors.lastname: Parisi
authors.forename: Carlo-Gabriele
authors.initials: CG
authors.lastname: Tocchetti
authors.forename: Fabio
authors.initials: F
authors.lastname: Pastore
authors.forename: Teresa
authors.initials: T
authors.lastname: Migliore
authors.forename: Carla
authors.initials: C
authors.lastname: Contaldi
authors.forename: Armando
authors.initials: A
authors.lastname: Caputi
authors.forename: Rosalba
authors.initials: R
authors.lastname: Romano
authors.forename: Massimo
authors.initials: M
authors.lastname: Chiariello
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000000981:diagnostic imaging* / Q000401:mortality*; D004108:Dilatation, Pathologic / Q000000981:diagnostic imaging; D004452:Echocardiography / Q000706:statistics & numerical data*; D019560:Echocardiography, Three-Dimensional / Q000379:methods*; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D015203:Reproducibility of Results; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D015996:Survival Rate