Kidney transplant half-life (t[1/2]) after rapid discontinuation of prednisone.
Protocols incorporating rapid discontinuation of prednisone (RDP) after kidney transplantation have been associated with good short-term results. However, concern remains that RDP will be associated with decreased long-term graft survival rates. We compared kidney transplant half-life (t1/2) for recipients treated with antibody induction, calcineurin inhibitor, antimetabolite, and RDP versus historical controls treated with antibody induction, calcineurin inhibitor, antimetabolite, and maintenance prednisone. For both living and deceased donor recipients, we found no difference between groups. We also found no differences in rate of graft loss to acute rejection or to tubular atrophy and interstitial fibrosis. Our study suggests that long-term graft outcome is not decreased when using RDP protocols versus chronic maintenance prednisone.
Matas
Arthur J
AJ
Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA. matas001@umn.edu
Gillingham
Kristen
K
Kandaswamy
Raja
R
Dunn
Ty B
TB
Payne
William D
WD
Sutherland
David E R
DE
Humar
Abhinav
A
D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000494:pharmacology*; D013997:Time Factors
D011241:Prednisone