Entrapment of hydrophobic drugs in nanoparticle monolayers with efficient release into cancer cells.
Gold nanoparticles functionalized with water-soluble zwitterionic ligands form kinetically stable complexes with hydrophobic drugs and dyes. These drugs and dyes are efficiently released into cells, as demonstrated through fluorescence microscopy and cytotoxicity assays. Significantly, there is little or no cellular uptake of particle, making these low toxicity particles promising for delivery applications.
Kim
Chae Kyu
CK
Department of Chemistry, University of Massachusetts at Amherst, Amherst, Massachusetts 01003, USA.
Ghosh
Partha
P
Pagliuca
Chiara
C
Zhu
Zheng-Jiang
ZJ
Menichetti
Stefano
S
Rotello
Vincent M
VM
D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006046:Gold / Q000737:chemistry; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D015394:Molecular Structure; D009369:Neoplasms / Q000473:pathology; D004364:Pharmaceutical Preparations / Q000737:chemistry*
D004364:Pharmaceutical Preparations; D006046:Gold