title: Evaluation of a fibrin preparation containing tranexamic acid (Adhexil) in a rabbit uterine horn model of adhesions with and without bleeding and in a model with two surgical loci.
abstract: OBJECTIVE
  To compare the efficacy of a fibrin preparation supplemented with tranexamic acid (Adhexil) with that of established devices, and to determine whether its effect is limited to the site of application.
  
  
  METHODS
  Rabbit uterine horns were abraded in nonbleeding and bleeding variants of an established adhesions model. In a separate study, a sidewall excision with approximation of the abraded cecum was added. Animals randomly received Adhexil at both, neither, or either loci.
  
  
  METHODS
  Laboratory study.
  
  
  METHODS
  Seventy-two female New Zealand White rabbits (Oryctolagus cuniculus).
  
  
  METHODS
  Adhexil, Seprafilm or SprayGel and Interceed.
  
  
  METHODS
  The extent of adhesions was evaluated 13 to 16 days after surgery.
  
  
  RESULTS
  Adhexil reduced adhesions (15 +/- 7%; 15 +/- 4%) compared with controls (74 +/- 13%; 78 +/- 9%) in the bleeding and nonbleeding models, respectively. The reductions resulting from the use of Seprafilm (39 +/- 17%; 34 +/- 14%) or SprayGel (61 +/- 18%; 43 +/- 14%) (n = 4) were not statistically significant. In the bleeding model, Interceed (48 +/- 15%) reduced adhesions only modestly.
  
  
  CONCLUSIONS
  In the combined uterine and sidewall model, Adhexil reduced selectively the extent and incidence of adhesions. The absolute and relative performance of Adhexil in an established adhesions model and in the presence of bleeding justifies its further investigation.
authors.affiliation: Synechion, Inc., PMB 238, 6757 Arapaho, Suite 711, Dallas, Texas, 75248, USA. synechion@aol.com
authors.forename: David M
authors.initials: DM
authors.lastname: Wiseman
authors.forename: Roberto
authors.initials: R
authors.lastname: Meidler
authors.forename: Yacov
authors.initials: Y
authors.lastname: Lyahovetsky
authors.forename: Eran
authors.initials: E
authors.lastname: Kurman
authors.forename: Sara
authors.initials: S
authors.lastname: Horn
authors.forename: Israel
authors.initials: I
authors.lastname: Nur
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D005337:Fibrin / Q000008:administration & dosage*; D006470:Hemorrhage / Q000473:pathology / Q000517:prevention & control; D006820:Hyaluronic Acid / Q000008:administration & dosage; D019106:Postoperative Hemorrhage / Q000473:pathology / Q000517:prevention & control; D011817:Rabbits; D000267:Tissue Adhesions / Q000473:pathology / Q000517:prevention & control*; D014148:Tranexamic Acid / Q000008:administration & dosage*; D014592:Uterine Hemorrhage / Q000473:pathology / Q000517:prevention & control*; D014599:Uterus / Q000187:drug effects / Q000473:pathology / Q000601:surgery*
chemical_list: D004338:Drug Combinations; C118198:Seprafilm; D014148:Tranexamic Acid; D005337:Fibrin; D006820:Hyaluronic Acid