Superficial necrolytic dermatitis associated with extrapancreatic glucagonoma in a dog.
An 11-year-old Shih Tzu presented with crusting and erythema, mainly on the abdomen and the root of the tail. Based on histopathological findings, blood examinations and necropsy findings, the condition was diagnosed as superficial necrolytic dermatitis associated with a glucagon-secreting extrapancreatic neuroendocrine tumour. Gross necropsy revealed tumour invasion into the spleen, liver, adrenal glands and mesenteric lymph nodes. Immunohistochemical analysis of the neoplastic cells revealed that the tumour was a glucagonoma, consistent with earlier findings of persistent glucagonaemia and hypoaminoacidaemia.
Mizuno
Takuya
T
Laboratory of Veterinary Internal Medicine, Yamaguci University, Yamaguchi, Japan. mizutaku@yamaguchi-u.ac.jp
Hiraoka
Hiroko
H
Yoshioka
Chihiro
C
Takeda
Yoshiho
Y
Matsukane
Yuki
Y
Shimoyama
Natsumi
N
Morimoto
Masahiro
M
Hayashi
Toshiharu
T
Okuda
Masaru
M
D000818:Animals; D003872:Dermatitis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005935:Glucagonoma / Q000150:complications / Q000662:veterinary*; D008297:Male