title: Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase.
abstract: A series of benzyl phenyl ethers (BPEs) is described that displays potent inhibition of bacterial phenylalanyl-tRNA synthetase. The synthesis, SAR, and select ADMET data are provided.
authors.affiliation: Pfizer Global Research and Development, Michigan Laboratories, Ann Arbor Campus, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. justin.montgomery@pfizer.com
authors.forename: Justin I
authors.initials: JI
authors.lastname: Montgomery
authors.forename: Peter L
authors.initials: PL
authors.lastname: Toogood
authors.forename: Kim M
authors.initials: KM
authors.lastname: Hutchings
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Narasimhan
authors.forename: Timothy
authors.initials: T
authors.lastname: Braden
authors.forename: Michael R
authors.initials: MR
authors.lastname: Dermyer
authors.forename: Angela D
authors.initials: AD
authors.lastname: Kulynych
authors.forename: Yvonne D
authors.initials: YD
authors.lastname: Smith
authors.forename: Joseph S
authors.initials: JS
authors.lastname: Warmus
authors.forename: Clarke
authors.initials: C
authors.lastname: Taylor
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000201:enzymology*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D020128:Inhibitory Concentration 50; D008956:Models, Chemical; D010647:Phenyl Ethers / Q000737:chemistry*; D010652:Phenylalanine-tRNA Ligase / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010647:Phenyl Ethers; D000255:Adenosine Triphosphate; D010652:Phenylalanine-tRNA Ligase