Treatment results of carcinoma in situ of the glottic larynx: 61 patients treated with radiotherapy.
OBJECTIVE
To review the Notre-Dame Hospital experience in the treatment of carcinoma in situ of the glottis by radiotherapy and to evaluate the different factors affecting local control and survival.


METHODS
Between January 1990 and June 2002, 61 patients presenting with carcinoma in situ of the glottis were treated with curative intent radiotherapy. No patients received either surgery or chemotherapy in the initial treatment of their cancer.


RESULTS
The median follow-up for the entire population was 3.2 years. The local control rate was 96% and 94% at 2 and 5 years, respectively. Overall survival was 100% and 90% at 2 and 5 years, respectively. No statistically significant prognostic factor could be identified either for local control or survival. No patient experienced severe treatment complications or death.


CONCLUSIONS
Radiotherapy offers excellent treatment results for carcinoma in situ of the glottic larynx, with few treatment complications. These results are comparable to those published in the literature and justify our choice of primary radiotherapy for carcinoma in situ of the glottis.
Charbonneau
Nicolas
N
Department of Hematology-Oncology, Notre-Dame Hospital, Montreal, Quebec. nicolas.charbonneau@umontreal.ca
Gélinas
Michel
M
del Vecchio
Pierre
P
Guertin
Louis
L
Larochelle
Daniel
D
Tabet
Jean-Claude
JC
Souliàres
Denis
D
Charpentier
Danielle
D
Félix Nguyen-Tân
Phuc
P
D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D016896:Treatment Outcome