Neurotropic effects of L-lysine in formation of pain-induced behavior.
In experiments on Wistar rats L-lysine (0.15, 0.5, 1.5, 5.0, 15.0, and 50.0 microg/kg intraperitoneally) exhibited a dose-dependent algic effect during electrocutaneous stimulation of the tail and dose-dependent effects in aggressive defense behavior caused by electrical painful stimulation of paws. It was found that the effect of L-lysine depended on situation determining the predominance of defense or aggression, rather than on the intensity of painful stimulation.
Severyanova
L A
LA
Department of Pathophysiology, Kursk State Medical University, Russia. makdol@mail.ru
Dolgintsev
M E
ME
Bobyntsev
I I
II
Kryukov
A A
AA
D000374:Aggression / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008239:Lysine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000502:physiology; D010146:Pain / Q000503:physiopathology / Q000523:psychology*; D017288:Pain Threshold / Q000187:drug effects / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar
D002491:Central Nervous System Agents; D018377:Neurotransmitter Agents; D008239:Lysine