Evaluations of labrador retrievers with exercise-induced collapse, including response to a standardized strenuous exercise protocol.
Clinical and metabolic variables were evaluated in 14 Labrador retrievers with exercise-induced collapse (EIC) before, during, and following completion of a standardized strenuous exercise protocol. Findings were compared with previously reported variables from 14 normal Labrador retrievers that participated in the same protocol. Ten of 14 dogs with EIC developed an abnormal gait during evaluation, and these dogs were significantly more tachycardic and had a more severe respiratory alkalosis after exercise compared to the normal dogs. Muscle biopsy characteristics and sequential lactate and pyruvate concentrations were normal. Genetic testing and linkage analysis excluded malignant hyperthermia as the cause of EIC. Common causes of exercise intolerance were eliminated, but the cause of collapse in EIC was not determined.
Taylor
Susan M
SM
Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada.
Shmon
Cindy L
CL
Adams
Vicki J
VJ
Mickelson
James R
JR
Patterson
Edward Ned E
EN
Shelton
G Diane
GD
D000818:Animals; D001706:Biopsy / Q000662:veterinary; D001774:Blood Chemical Analysis; D001831:Body Temperature; D002331:Carnitine / Q000032:analysis / Q000097:blood / Q000652:urine; D004283:Dog Diseases / Q000235:genetics / Q000503:physiopathology*; D004285:Dogs / Q000235:genetics / Q000502:physiology*; D005260:Female; D008297:Male; D008305:Malignant Hyperthermia / Q000662:veterinary; D010805:Physical Conditioning, Animal / Q000009:adverse effects*; D052097:Quadriceps Muscle / Q000601:surgery; D012146:Rest / Q000502:physiology; D019837:Ryanodine Receptor Calcium Release Channel / Q000235:genetics
D019837:Ryanodine Receptor Calcium Release Channel; D002331:Carnitine