title: Temporal signaling and differential expression of Bordetella iron transport systems: the role of ferrimones and positive regulators.
abstract: The bacterial respiratory pathogens Bordetella pertussis and Bordetella bronchiseptica employ multiple alternative iron acquisition pathways to adapt to changes in the mammalian host environment during infection. The alcaligin, enterobactin, and heme utilization pathways are differentially expressed in response to the cognate iron source availability by a mechanism involving substrate-inducible positive regulators. As inducers, the iron sources function as chemical signals termed ferrimones. Ferrimone-sensing allows the pathogen to adapt and exploit early and late events in the infection process.
authors.affiliation: Department of Microbiology, University of Minnesota Medical School, MMC 196, Minneapolis, MN 55455-0312, USA.
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Brickman
authors.forename: Sandra K
authors.initials: SK
authors.lastname: Armstrong
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001884:Bordetella / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D001885:Bordetella Infections / Q000378:metabolism; D004758:Enterobactin / Q000737:chemistry / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D006418:Heme / Q000235:genetics / Q000378:metabolism; D006801:Humans; D006877:Hydroxamic Acids / Q000737:chemistry / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D017262:Siderophores / Q000737:chemistry / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D001426:Bacterial Proteins; D006877:Hydroxamic Acids; D017262:Siderophores; C092056:alcaligin; D004758:Enterobactin; D006418:Heme; D007501:Iron