Oncomirs: from tumor biology to molecularly targeted anticancer strategies.
Deregulation of microRNA (miRNA) promotes carcinogenesis, as these molecules can act as oncogenes or tumor suppressor genes. Here we provide an overview of miRNA biology, discuss the most recent findings on miRNA and cancer development/progression, and report on how tumor-related miRNAs (oncomirs) are being used to develop novel cancer specific therapeutic approaches.
Mocellin
Simone
S
Dept. Oncological & Surgical Sciences, University of Padova, via Giustiniani 2, 35128 Padova, Italy. simone.mocellin@unipd.it
Pasquali
Sandro
S
Pilati
Pierluigi
P
D000970:Antineoplastic Agents / Q000494:pharmacology; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy*; D034622:RNA Interference; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism
D000970:Antineoplastic Agents; D035683:MicroRNAs; D012334:RNA, Neoplasm