Recombination rates of human microRNA.
The fact that microRNAs play a role in almost all biological processes is well established, as is the importance of recombination in generating genome variability. However, the association between microRNAs and recombination remains largely unknown. In order to investigate the recombination patterns of microRNAs, we performed a comprehensive analysis of the recombination rate of human microRNAs. We observed that microRNAs that are expressed in several tissues tend to have lower recombination rates than tissue-specific microRNAs. Additionally, microRNAs that are associated with a number of diseases are also likely to have lower recombination rates. Furthermore, microRNAs with higher expression levels are found to have fewer recombination events. These findings reveal patterns in recombination rates of microRNAs that could help in understanding the function, evolution, and disease-related roles of microRNAs.
Zhao
Huizhi
H
LIAMA Center for Computational Medicine and National Lab of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Wang
Dong
D
Liu
Bing
B
Jiang
Xingpeng
X
Zhang
Jing
J
Fan
Ming
M
Fan
Zhengjie
Z
Chen
Ying
Y
Song
Sonya Wei
SW
Gao
Wei
W
Jiang
Tianzi
T
Cui
Qinghua
Q
D004194:Disease / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics*; D011995:Recombination, Genetic
D035683:MicroRNAs