Role of potassium and chlorine channels in the regulation of thymocyte volume in rats.
Regulatory decrease in thymocyte volume under conditions of osmotic stress was abolished by potassium and chlorine channel blockers. Osmotic stress-activated chlorine channels belong to 2 pharmacological types. The maxi-anion channel is sensitive to Gd(3+). The volume-sensitive outwardly rectifying chlorine channel is inhibited with glybenclamide and phloretin.
Kurbannazarova
R S
RS
Laboratory of Molecular Physiology, Institute of Physiology and Biophysics, Uzbekistan Academy of Sciences, Uzbekistan. ravshansabirov@yahoo.com
Tashmukhamedov
B A
BA
Sabirov
R Z
RZ
D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology; D000818:Animals; D048429:Cell Size / Q000187:drug effects; D018118:Chloride Channels / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005682:Gadolinium / Q000494:pharmacology; D005905:Glyburide / Q000494:pharmacology; D066298:In Vitro Techniques; D017136:Ion Transport / Q000187:drug effects; D009997:Osmotic Pressure; D010693:Phloretin / Q000494:pharmacology; D026902:Potassium Channel Blockers / Q000494:pharmacology; D015221:Potassium Channels / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism*
D018118:Chloride Channels; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D005682:Gadolinium; C038958:gadolinium chloride; D010693:Phloretin; D005905:Glyburide