Involvement of the GABA-B system in the mechanism of action of ultralow-dose antibodies to S-100 protein.
The involvement of the GABA-B neurotransmitter system in the realization of anxiolytic and antidepressant activities of ultralow-dose antibodies to S-100 protein is demonstrated. Simultaneous injection of ultralow-dose antibodies to S-100 protein and GABA-B receptor agonist baclofen reduced the anxiolytic and antidepressant effects of the drug, while GABA-B receptor antagonist faclofen stimulated the anxiolytic and reduced the antidepressant effect of ultralow-dose antibodies to S-100 protein. The effect of ultralow-dose antibodies to S-100 protein on the GABA-B-ergic system differs from that of benzodiazepine anxiolytics (diazepam) and tricyclic antidepressants (amitryptiline) not affecting this transmitter system.
Kheifez
I A
IA
Materia Medica Holding, Moscow. heifezia@materiamedica.ru
Molodavkin
G M
GM
Voronina
T A
TA
Dugina
Yu L
YL
Sergeeva
S A
SA
Epstein
O I
OI
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D000906:Antibodies / Q000008:administration & dosage*; D000928:Antidepressive Agents / Q000494:pharmacology; D001007:Anxiety / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D001418:Baclofen / Q000494:pharmacology; D003863:Depression / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D003975:Diazepam / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D008297:Male; D051381:Rats; D018080:Receptors, GABA-B / Q000276:immunology*; D009418:S100 Proteins / Q000037:antagonists & inhibitors* / Q000276:immunology*
D014151:Anti-Anxiety Agents; D000906:Antibodies; D000928:Antidepressive Agents; D018755:GABA Agonists; D018756:GABA Antagonists; D018080:Receptors, GABA-B; D009418:S100 Proteins; D001418:Baclofen; D003975:Diazepam