RAGE polymorphisms, renal function and histological finding at 12 months after renal transplantation.
OBJECTIVE
Rage (receptor for advanced glycation end products) is involved in pathogenesis of many diseases. The aim of the study was to test whether polymorphisms of RAGE gene are associated with the outcome of kidney transplantation.


METHODS
Four polymorphisms of the RAGE gene (-429T/C, -374T/A, Gly82Ser and 2184A/G) were assessed in 145 renal transplant recipients and their relationship to histological changes in 12 months protocol kidney graft biopsy and renal function was examined.


RESULTS
Genotype frequencies of each polymorphism corresponded to expected frequencies according to Hardy-Weinberg equilibrium. No differences between allelic and genotype frequencies among patients with normal histological findings, chronic allograft nephropathy and subclinical rejection were observed.


CONCLUSIONS
This is the first study on polymorphisms of the RAGE gene in patients with the transplanted kidney. No association of RAGE selected gene polymorphisms with 12-months outcome of renal transplants was shown in study.
Kalousová
Marta
M
Institute of Clinical Chemistry and Laboratory Diagnostics, First Faculty of Medicine and General University Hospital, Charles University, Karlovo nam. 32, 121 11 Prague 2, Czech Republic. marta.kalousova@seznam.cz
Brabcová
Irena
I
Germanová
Anna
A
Jáchymová
Marie
M
Matl
Ivo
I
Mestek
Oto
O
Bandúr
Stepán
S
Zima
Tomás
T
Viklický
Ondrej
O
D001706:Biopsy; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007668:Kidney / Q000473:pathology* / Q000503:physiopathology*; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics*; D013997:Time Factors
D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic