title: Apoptosis in animal models of virus-induced disease.
abstract: Apoptosis is associated with virus-induced human diseases of the central nervous system, heart and liver, and causes substantial morbidity and mortality. Although virus-induced apoptosis is well characterized in individual cells in cell culture, virus-induced apoptosis in vivo and the role of apoptosis in virus-induced disease is not well established. This review focuses on animal models of virus-induced diseases of the central nervous system, heart and liver that provide insights into the role of apoptosis in pathogenesis, the pathways involved and the potential therapeutic implications.
authors.affiliation: Department of Neurology, University of Colorado, Denver Health Sciences Programs, Anschutz Medical Campus, Aurora, Colorado 80045, USA. Penny.Clarke@uchsc.edu
authors.forename: Penny
authors.initials: P
authors.lastname: Clarke
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Tyler
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D051381:Rats; D014777:Virus Diseases / Q000378:metabolism*
chemical_list: D020169:Caspases