Severe postvaccinia encephalitis with acute disseminated encephalomyelitis: recovery with early intravenous immunoglobulin, high-dose steroids, and vaccinia immunoglobulin.
We report the second case of severe postvaccinial encephalitis with acute disseminated encephalomyelitis since smallpox vaccination was reintroduced in 2002. Both affected patients responded dramatically with early intervention of intravenous immunoglobulin. Our patient, who also received concurrent vaccinia immunoglobulin and corticosteroids, demonstrated full recovery.
Van Dam
Cornelius N
CN
Department of Internal Medicine/Infectious Diseases, University of North Carolina Area Health Education Centers Program, Moses Cone Hospital, Greensboro, NC 27401-1020, USA. kvandam@med.unc.edu
Syed
Samina
S
Eron
Joseph J
JJ
Ostrander
Matthew
M
Engler
Renata J M
RJ
Damon
Inger
I
Montgomery
Jay R
JR
Tong
Suxiang
S
Adimora
Adaora A
AA
Kahn
Kevin A
KA
Ruone
Susan
S
Anderson
Larry
L
Weber
David J
DJ
D000328:Adult; D004673:Encephalomyelitis, Acute Disseminated / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D008297:Male; D012900:Smallpox Vaccine / Q000009:adverse effects*; D013256:Steroids / Q000627:therapeutic use*; D016896:Treatment Outcome; D014615:Vaccinia / Q000150:complications* / Q000188:drug therapy*; D055815:Young Adult
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D012900:Smallpox Vaccine; D013256:Steroids