title: Plasma polyunsaturated fatty acids and regional cerebral glucose metabolism in major depression.
abstract: Deficiencies in polyunsaturated essential fatty acids (PUFA) are implicated in mood disorders, although mechanisms of action and regional specificity in the brain are unknown. We hypothesized that plasma phospholipid PUFA levels are correlated with regionally specific relative cerebral metabolic rates of glucose (rCMRglu). Medication-free depressed subjects (N=29) were studied using [(18)F]-fluoro-2-deoxyglucose positron emission tomography. Docosahexaenoic acid (22:6n-3), arachidonic acid (20:4n-6), and eicosapentaenoic acid (20:5n-3) were assessed as a percentage of total phospholipid PUFA (DHA%, AA%, and EPA%, respectively). DHA% and AA% correlated positively with rCMRglu in temporoparietal cortex. In addition, DHA% correlated negatively with rCMRglu in prefrontal cortex and anterior cingulate. No correlations were seen with EPA%. Thus, under conditions of low plasma DHA, rCMRglu was higher in temporoparietal cortex and lower in anterior cingulate/prefrontal cortex. Opposing effects of DHA on these regions is a hypothesis that could be addressed in future prospective studies with n-3 supplementation. This pilot study is the first to demonstrate fatty acid and regionally specific correlations in the brain between plasma PUFA and rCMRglu in humans.
authors.affiliation: Department of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, 1051 Riverside Drive, Unit 42, New York, NY 10032, USA. es2316@columbia.edu
authors.forename: M Elizabeth
authors.initials: ME
authors.lastname: Sublette
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Milak
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Hibbeln
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Freed
authors.forename: Maria A
authors.initials: MA
authors.lastname: Oquendo
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Malone
authors.forename: Ramin V
authors.initials: RV
authors.lastname: Parsey
authors.forename: J John
authors.initials: JJ
authors.lastname: Mann
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism*; D003865:Major Depressive Disorder / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D049268:Positron-Emission Tomography
chemical_list: D005231:Fatty Acids, Unsaturated; D019788:Fluorodeoxyglucose F18; D005947:Glucose