[Modified FOLFOX6 was effective for advanced adenocarcinoma with unknown origin in a patient with Crohn's disease].
A 47-year-old man who was diagnosed as Crohn's disease at the age of 27 became aware of a mass on the forehead. CT and PET scan revealed many scattered tumors in his body. The CEA level was 4424 ng/ml. Primary lesion was not detected by the surveillance of whole gastro-intestinal tract. Liver tumor biopsy samples were histologicaly analyzed and were diagnosed as adenocarcinoma. Further immunohistochemical analysis revealed that the biopsy material had colonic character determined by positive CK20 and negative CK7 staining. Therefore, we performed 12 cycles of mFOLFOX6 chemotherapy. It was effective with the reduced size of tumors and the decreased level of CEA.
Hayashi
Yoshito
Y
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine. y.hayashi@gh.med.osaka-u.ac.jp
Nishida
Tsutomu
T
Kondo
Jumpei
J
Yamamoto
Katsumi
K
Iijima
Hideki
H
Tsutsui
Shusaku
S
Hiramatsu
Naoki
N
Tsujii
Masahiko
M
Tsuji
Shingo
S
Ito
Hiroaki
H
Takehara
Tetsuo
T
Hayashi
Norio
N
D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003424:Crohn Disease / Q000150:complications*; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D009382:Neoplasms, Unknown Primary / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D009944:Organoplatinum Compounds / Q000008:administration & dosage
D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil