title: Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes.
abstract: Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3+ T cells were revealed around the recanalization sites within the abdominal aorta. CD4+ T cells were almost equal in number to CD8+ T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).
authors.affiliation: Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Edo
authors.forename: Kosuke
authors.initials: K
authors.lastname: Miyai
authors.forename: Sho
authors.initials: S
authors.lastname: Ogata
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Hiroi
authors.forename: Susumu
authors.initials: S
authors.lastname: Tominaga
authors.forename: Satoshi
authors.initials: S
authors.lastname: Aiko
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kawai
mesh_terms: D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012907:Smoking; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013919:Thromboangiitis Obliterans / Q000276:immunology* / Q000473:pathology* / Q000503:physiopathology