An efficient synthesis of terminal allenes from terminal 1-alkynes.
We have developed a modified method for the synthesis of terminal allenes from terminal 1-alkyne: The reaction of 1-alkynes with 1.8 equiv of Cy(2)NH and 2.5 equiv of paraformaldehyde mediated by CuI (0.5 equiv) in refluxing dioxane may produce terminal allenes in much higher yields than the previously reported protocol and many functional groups such as mesylate, hydroxyl group, ether, amide, etc. may be tolerated.
Kuang
Jinqiang
J
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, People's Republic of China.
Ma
Shengming
S