title: An alternative convenient synthesis of piperidazine-3-carboxylic acid derivatives.
abstract: The short-step synthesis of the unsubstituted, 5-hydroxy- and 5-chloropiperidazine-3-carboxylic acids using an aza Diels-Alder reaction between the 1,3-diene and azodicarboxylate was described. This synthetic methodology could be used for the preparation of the optically active piperazic acid in a 35% overall yield.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan.
authors.forename: Mamoru
authors.initials: M
authors.lastname: Kaname
authors.forename: Masae
authors.initials: M
authors.lastname: Yamada
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Yoshifuji
authors.forename: Haruki
authors.initials: H
authors.lastname: Sashida
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D000077489:Piperazine; D010879:Piperazines / Q000737:chemistry*; D011724:Pyridazines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D010879:Piperazines; D011724:Pyridazines; D000077489:Piperazine