title: [Tinidazole versus cefazolin in antibiotic prophylaxis of vaginal and abdominal hysterectomy].
abstract: OBJECTIVE
  to compare the efficacy of tinidazole and cephazolin on the febrile and infectious morbidity of post vaginal and abdominal hysterectomy antibiotic prophylaxis.
  
  
  METHODS
  randomized clinical study, where women admitted to hospital for hysterectomy were randomly allocated in one of the following antibiotic prophylaxis groups: Group C (2 g of IV cephazolin in the anesthetic induction); Group T (2 g of tinidazole orally, 12 hours before the surgery); or Group C+T (2 g of tinidazole orally 12 hours before the surgery and 2g of IV cephazolin in the anesthetic induction). Cervicovaginal smears were collected for specific cultures and the diagnosis of bacterial vaginosis (BV) was based in Amsel and Nugent's criteria. The patients were reevaluated 7 and 30 days after the surgery for signs of febrile and/or infectious morbidity. The chi2 or the Fisher's exact test was used to assess differences among the three groups, with a significance level of 5%. The sample power (1-beta) was calculated through the SAS program.
  
  
  RESULTS
  seven days after the hysterectomy, infectious morbidity was diagnosed in 6.6% of the women, but with no significant difference among the three groups studied (p=0.12). There was no febrile or infectious morbidity at the immediate post-surgical period or after 30 days from the surgery. BV ratio at the pre-surgical period was significantly higher among the women submitted to vaginal hysterectomy, rather than among the ones submitted to abdominal hysterectomy (27 versus 7%, p=0.02). BV ratio was also higher after 30 days, among the women submitted to vaginal hysterectomy (20 versus 8%), though without statistical significance (p=0.19).
  
  
  CONCLUSIONS
  the use of tinidazole, isolated or associated with cephazolin has not presented higher efficacy, than the use of cephazolin, alone to prevent febrile or infectious morbidity post hysterectomy. The high ratio of BV at the immediate pre-surgery period among the women submitted to vaginal hysterectomy suggests that this infection must be better investigated and properly treated before the surgery.
authors.affiliation: Departamento de Tocoginecologia, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil. jsimoes@caism.unicamp.br
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Simões
authors.forename: Michelle Garcia
authors.initials: MG
authors.lastname: Discacciati
authors.forename: Giana Balestro
authors.initials: GB
authors.lastname: Poletti
authors.forename: Eliane
authors.initials: E
authors.lastname: Brolazo
authors.forename: Gabriela Daoud
authors.initials: GD
authors.lastname: Crema
authors.forename: Cláudia Ferreira
authors.initials: CF
authors.lastname: Pereira
mesh_terms: D000005:Abdomen; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000379:methods*; D008875:Middle Aged; D014011:Tinidazole / Q000627:therapeutic use*; D014621:Vagina
chemical_list: D000900:Anti-Bacterial Agents; D014011:Tinidazole; D002437:Cefazolin