title: Acute complete splenic infarction in a patient with Hirschsprung's disease and literature review of complete splenic infarction.
abstract: Here we report a case of Hirschsprung's disease presenting with acute complete splenic infarction due to thrombus in the splenic vena. MTHFR C677T (methylenetetrahydrofolate) gene homozygote mutation was a risk factor for thrombosis. According to our knowledge, this is the first report for a Hirschsprung's disease patient with acute complete splenic infarct due to isolated splenic vein thrombosis accompanied by MTHFR C677T gene homozygote mutation.
authors.affiliation: Department of Hematology, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. nilvecay@yahoo.com
authors.forename: N
authors.initials: N
authors.lastname: Guler
authors.forename: O
authors.initials: O
authors.lastname: Yapici
authors.forename: D
authors.initials: D
authors.lastname: Erdem
authors.forename: G
authors.initials: G
authors.lastname: Ogur
authors.forename: D
authors.initials: D
authors.lastname: Ozatli
authors.forename: T
authors.initials: T
authors.lastname: Bakir
mesh_terms: D000328:Adult; D005260:Female; D006627:Hirschsprung Disease / Q000150:complications*; D006720:Homozygote; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D017354:Point Mutation; D013159:Splenic Infarction / Q000209:etiology*; D013162:Splenic Vein; D013927:Thrombosis
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)