Two new flavonol glycosides from Lamium amplexicaule L. and their in vitro free radical scavenging and tyrosinase inhibitory activities.
Two new flavonol glycosides, kaempferol 3-O-[beta-D-glucopyranosyl-(1-->4)][alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside and quercetin 3-O-[beta-D-glucopyranosyl-(1-->4)][alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside, together with three known flavonoids were isolated using column chromatography from the aerial parts of Lamium amplexicaule (Labiatae). In addition, the five isolates were evaluated for their in vitro free radical scavenging (EC50 values, 14.1-63.9 microg/mL) and tyrosinase inhibitory activities (IC50 values, 110.4-193.5 microg/mL).
Nugroho
Agung
A
Department of Pharmaceutical Engineering, Sangji University, Wonju, Korea.
Choi
Jun-Kil
JK
Park
Jong-Hee
JH
Lee
Kyung-Tae
KT
Cha
Bae Cheon
BC
Park
Hee-Juhn
HJ
D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry* / Q000494:pharmacology*; D019259:Lamivudine / Q000737:chemistry*; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*
D047309:Flavones; D016166:Free Radical Scavengers; D006027:Glycosides; D019259:Lamivudine; D014442:Monophenol Monooxygenase