title: Autologous hematopoietic stem cell transplantation for type 1 diabetes.
abstract: In this review, we present (1) the scientific basis for the use of high-dose immunosuppression followed by autologous peripheral blood hematopoietic stem cell transplantation for newly diagnosed type 1 diabetes (T1D); (2) an update of the clinical and laboratory outcome of 20 patients transplanted at the University Hospital of the Ribeirão Preto Medical School, University of São Paulo, Brazil, and followed up to January/2008, including 4 relapses among 19 patients without previous ketoacidosis; (3) a commentary on criticisms to our article that appeared in four articles from the scientific literature; and (4) a discussion of the prospectives for cellular therapy for T1D.
authors.affiliation: Department of Clinical Medicine, Ribeirão Preto School of Medicine, University of São Paulo, Ribeirão Preto, Brazil. jcvoltar@fmrp.usp.br
authors.forename: Júlio C
authors.initials: JC
authors.lastname: Voltarelli
authors.forename: Carlos E B
authors.initials: CE
authors.lastname: Couri
authors.forename: Ana B P L
authors.initials: AB
authors.lastname: Stracieri
authors.forename: Maria C
authors.initials: MC
authors.lastname: Oliveira
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Moraes
authors.forename: Fabiano
authors.initials: F
authors.lastname: Pieroni
authors.forename: George M N
authors.initials: GM
authors.lastname: Barros
authors.forename: Maria Isabel A
authors.initials: MI
authors.lastname: Madeira
authors.forename: Kelen C R
authors.initials: KC
authors.lastname: Malmegrim
authors.forename: Maria C
authors.initials: MC
authors.lastname: Foss-Freitas
authors.forename: Belinda P
authors.initials: BP
authors.lastname: Simões
authors.forename: Milton C
authors.initials: MC
authors.lastname: Foss
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Squiers
authors.forename: Richard K
authors.initials: RK
authors.lastname: Burt
mesh_terms: D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000628:therapy*; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D051379:Mice; D008954:Models, Biological; D014182:Transplantation, Autologous