title: The validation of the disease-specific questionnaire for health-related quality of life in Thai patients with hemifacial spasm.
abstract: OBJECTIVE
  To investigate the reliability and validity of the Thai version of disease-specific health-related quality of life instrument for patients with hemifacial spasm (HFS) as well as their response to botulinum toxin treatment.
  
  
  METHODS
  A Thai version of HFS-30 has been developed with the permission of the author. Thirty patients with HFS were asked to complete this Thai HFS-30, the 6-point disability scale before treatment and between four and six weeks after botulinum toxin injections. Peak improvement (0-100%) was subjectively assessed by each patient between four and six weeks after injection. They were also asked to answer the existing Thai SF-36 questionnaire before treatment to test its correlation with Thai HFS-30. Another group of ten patients completed the questionnaire and then a second identical copy after a 2-week interval. The reliability, validity, and responsiveness were subsequently analyzed.
  
  
  RESULTS
  The Thai HFS-30 showed a Cronbach's alpha coefficient of 0.78 and no significant difference of a test-retest reliability. The total content validity was 0.88 (range 0.5-1.0). There were good correlations between both the Physical and Mental Health parts of the Thai HFS-30 and Thai SF-36 (p < 0.05 and p < 0.01, respectively). The Thai HFS-30 also demonstrated a response to treatment similar to the 6-point disability scale and the peak improvement.
  
  
  CONCLUSIONS
  The Thai version of HFS-30 is a valid, reliable, and sensitive to change instrument for disease specific health-related quality of life assessment.
authors.affiliation: Division of Neurology, Department of Medicine, Songklanagarind Hospital, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. ssuwanna@medicine.psu.ac.th
authors.forename: Suwanna
authors.initials: S
authors.lastname: Setthawatcharawanich
authors.forename: Nipat
authors.initials: N
authors.lastname: Aui-aree
authors.forename: Kitti
authors.initials: K
authors.lastname: Limapichart
authors.forename: Pornchai
authors.initials: P
authors.lastname: Satirapunya
authors.forename: Kanitpong
authors.initials: K
authors.lastname: Phabphal
mesh_terms: D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use*; D001905:Botulinum Toxins / Q000627:therapeutic use*; D005260:Female; D006305:Health Status Indicators; D006306:Health Surveys; D019569:Hemifacial Spasm / Q000188:drug therapy / Q000523:psychology*; D006801:Humans; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D011581:Psychological Tests; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D013785:Thailand
chemical_list: D018726:Anti-Dyskinesia Agents; D001905:Botulinum Toxins