title: Prognostic factors of pulmonary metastasectomy for colorectal carcinomas.
abstract: BACKGROUND
  Pulmonary metastasectomy for colorectal carcinoma is a well-accepted procedure; however, reports on indications and prognostic factors are inconsistent. This study was designed to clarify a role for resection of pulmonary metastases for such tumors and to define the patients who benefit from pulmonary metastasectomy.
  
  
  METHODS
  Between 1990 and 2007, 84 patients with pulmonary metastases from colorectal carcinomas underwent curative pulmonary resection. All patients had obtained or had obtainable locoregional control of their primary tumors. Various perioperative variables were investigated retrospectively to confirm a role for metastasectomy and to analyze prognostic factors for overall survival and disease-free survival after metastasectomy.
  
  
  RESULTS
  Overall survival rate after metastasectomy was 60.5% and 48.4% at 5 and 10 years, respectively. Disease-free survival rate was 34.4% and 30.6% at 5 and 10 years after pulmonary resection, respectively. On multivariate analysis, patients with unilateral pulmonary metastasis presented a significantly favorable overall survival (P = 0.045). In contrast, there was no significant prognostic factor for disease-free survival.
  
  
  CONCLUSIONS
  Current practice of pulmonary metastasectomy for colorectal carcinoma in our institution was well justified. Our study confirmed that unilateral pulmonary metastasis was significantly relevant to a better prognosis.
authors.affiliation: Department of Thoracic Surgery, Graduate School of Medicine, Sakyo-ku, Kyoto University, 54 Shogoin-Kawahara-cho, Kyoto 606-8507, Japan.
authors.forename: Fengshi
authors.initials: F
authors.lastname: Chen
authors.forename: Nobuharu
authors.initials: N
authors.lastname: Hanaoka
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Takuji
authors.initials: T
authors.lastname: Fujinaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Sonobe
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shoji
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sakai
authors.forename: Ryo
authors.initials: R
authors.lastname: Miyahara
authors.forename: Toru
authors.initials: T
authors.lastname: Bando
authors.forename: Kenichi
authors.initials: K
authors.lastname: Okubo
authors.forename: Toshiki
authors.initials: T
authors.lastname: Hirata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000379:methods*; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate