title: [Primary cutaneous histoplasmosis: case report on an immunocompetent patient and review of the literature].
abstract: This report describes a case of primary cutaneous histoplasmosis in a 45-year-old male. The presentation consisted of an erythematous nodule on the back of the right hand, accompanied by nontender regional lymphadenomegaly that developed following local trauma that occurred during military training in a tunnel inhabited by bats. Histological examination of a biopsy specimen from the skin lesion showed granulomatous infiltrate, but did not show fungal elements. Culturing of this material, incubated in Sabouraud agar, showed growth of Histoplasma capsulatum. No evidence of systemic involvement or immunosuppression was found. Treatment with 400 mg/day of itraconazole orally for six months resulted in complete remission of the lesion, which was maintained one year after the end of the treatment.
authors.affiliation: Serviço de Infectologia, Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, RJ, Brazil. saheki@gmail.com
authors.forename: Mauricio Naoto
authors.initials: MN
authors.lastname: Saheki
authors.forename: Armando de Oliveira
authors.initials: Ade O
authors.lastname: Schubach
authors.forename: Mariza de Matos
authors.initials: Mde M
authors.lastname: Salgueiro
authors.forename: Fátima
authors.initials: F
authors.lastname: Conceição-Silva
authors.forename: Bodo
authors.initials: B
authors.lastname: Wanke
authors.forename: Márcia
authors.initials: M
authors.lastname: Lazera
mesh_terms: D003881:Dermatomycoses / Q000175:diagnosis* / Q000382:microbiology; D006229:Hand Dermatoses / Q000175:diagnosis* / Q000382:microbiology; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008875:Middle Aged