title: The Chiptip: a novel tool for automated patch clamp.
abstract: To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than 50 cells, and the addition of drugs for screening can be limited to very low volumes down to 1 microL. This apparatus is suitable for the study small cells, subcellular organelles and bacteria.
authors.affiliation: Flyion GmbH, Waldhäuserstr. 64, D-72076 Tübingen, Germany. info@flyion.com
authors.forename: Albrecht
authors.initials: A
authors.lastname: Lepple-Wienhues
authors.forename: Dirck
authors.initials: D
authors.lastname: Lassen
authors.forename: Alexander
authors.initials: A
authors.lastname: Hümmer
authors.forename: Uwe
authors.initials: U
authors.lastname: Czubayko
authors.forename: Martina
authors.initials: M
authors.lastname: Knirsch
authors.forename: Andjelko
authors.initials: A
authors.lastname: Golubovic
mesh_terms: D000818:Animals; D001331:Automation; D001419:Bacteria / Q000187:drug effects; D002477:Cells / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D018408:Patch-Clamp Techniques / Q000295:instrumentation*