Does colorectal cancer clinical advancement affect adhesion molecules (sP-selectin, sE-selectin and ICAM-1) concentration?
Adhesion molecules take part in physiological and pathological processes. They involved in inflammatory reactions and play important role in tumor invasion and the development of metastases. Soluble forms of P-selectin, E-selectin and ICAM-1 have been described in this study in patient with colorectal cancer. Plasma was obtained from 44 patients with colorectal cancer and 34 control subject's prior surgery, by an enzyme-linked immunosorbent assay (ELISA). The patients were divided according to TNM classification. Plasma level of all three molecules was significantly higher in colorectal cancer patients than in the control (p < 0.001). The highest level of sE-selectin and ICAM-1 were observed in patients with liver metastasis. There was no correlation between sP-selectin and sE-selectin, but we found a significant correlation between sE-selectin and ICAM-1 in all patients. These findings suggest that plasma concentration of E-selectin and ICAM-1 may indicate tumor progression and liver metastasis.
Dymicka-Piekarska
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Department of Clinical Laboratory Diagnostics, Medical University of Bialystok, Poland. vpiekarska@yahoo.com
Kemona
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D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology*; D019040:E-Selectin / Q000097:blood*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000556:secondary; D008297:Male; D009367:Neoplasm Staging; D019007:P-Selectin / Q000097:blood*; D017410:Practice Guidelines as Topic
D019040:E-Selectin; D019007:P-Selectin; D018799:Intercellular Adhesion Molecule-1