MYO9B polymorphisms in multiple sclerosis.
Single-nucleotide polymorphisms (SNPs) in the 3' region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS.
Kemppinen
Anu
A
Department of Molecular Medicine, National Public Health Institute and Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland.
Suvela
Minna
M
Tienari
Pentti J
PJ
Elovaara
Irina
I
Koivisto
Keijo
K
Pirttilä
Tuula
T
Reunanen
Mauri
M
Rautakorpi
Ilkka
I
Hillert
Jan
J
Lundmark
Frida
F
Oturai
Annette
A
Ryder
Lars
L
Harbo
Hanne F
HF
Celius
Elisabeth G
EG
Palotie
Aarno
A
Daly
Mark
M
Peltonen
Leena
L
Saarela
Janna
J
D016022:Case-Control Studies; D005190:Family; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D009218:Myosins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics
C113469:myosin IXB; D009218:Myosins