title: Aplastic anemia and concomitant autoimmune diseases.
abstract: The association of aplastic anemia (AA) with other autoimmune diseases (AID) has been described but so far not systematically evaluated. We assessed the incidence and the outcome of concomitant AID in a retrospective, single-center study of 243 patients with severe AA treated between 1974 and 2006 with either immunosuppression (186) or hematopoietic stem cell transplantation (57) and a median follow-up time of 9.3 years (0-33). Clinically manifest AID were observed in 24 out of 243 (10 +/- 3.7%) patients. Age at diagnosis of AA was significantly younger in patients without AID compared to patients with AID (median, 20 versus 52 years; P < 0.001). In 12 patients where the diagnosis of AID was done before AA therapy, response to antithymocyte globulin was good for AA (ten out of 12) but not for AID (2 out of 12). In 13 patients in which AID occurred after first-line therapy, the median time to the AID was 7 years (range 3 months-27.5 years).
authors.affiliation: Basel Stem Cell Transplant Team, University Hospital Basel, Basel, Switzerland.
authors.forename: Magnus P
authors.initials: MP
authors.lastname: Stalder
authors.forename: Alicia
authors.initials: A
authors.lastname: Rovó
authors.forename: Jörg
authors.initials: J
authors.lastname: Halter
authors.forename: Dominik
authors.initials: D
authors.lastname: Heim
authors.forename: Tobias
authors.initials: T
authors.lastname: Silzle
authors.forename: Jakob
authors.initials: J
authors.lastname: Passweg
authors.forename: Johannes
authors.initials: J
authors.lastname: Rischewski
authors.forename: Martin
authors.initials: M
authors.lastname: Stern
authors.forename: Caroline
authors.initials: C
authors.lastname: Arber
authors.forename: Andreas
authors.initials: A
authors.lastname: Buser
authors.forename: Sandrine
authors.initials: S
authors.lastname: Meyer-Monard
authors.forename: André
authors.initials: A
authors.lastname: Tichelli
authors.forename: Alois
authors.initials: A
authors.lastname: Gratwohl
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000150:complications* / Q000453:epidemiology* / Q000628:therapy; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000961:Antilymphocyte Serum