title: Ischaemic stroke patients with heterozygous factor V Leiden present with multiple brain infarctions and widespread atherothrombotic disease.
abstract: Factor V Leiden (FVL) mutation is a risk factor for venous and, to a degree, arterial thrombosis. It is unknown whether and how FVL affects the manifestations of ischaemic stroke (IS). We assessed the clinical, laboratory, radiological, and prognostic characteristics in an observational study with adult IS patients having FVL. We tested 860 patients with first-ever IS for FVL and found 48 FVL positive patients. Detailed clinical, laboratory, and radiological evaluation were compared with that of 144 (1:3) gender and age matched IS patients without FVL. All patients underwent a prognostic evaluation at an average of five years follow-up. Despite the relatively young age (mean 48.5 years, range 44-54 years) of the FVL positive IS patients, peripheral arterial occlusive disease (PAOD), coronary artery disease (CAD), and previous transient cerebrovascular event occurred more frequently compared with controls. Family history of cardiovascular disease (CVD) and multiple silent brain infarctions were revealed in half of the FVL positive patients, whereas these were seldom encountered among controls. Stroke severity, long-term recovery, and recurrence rates seemed similar irrespective of FVL status. Our findings indicate that the clinical profile of IS patients with FVL associated with wider manifestation of atherothrombosis, positive family history of arterial thrombosis, and presence of multiple silent infarctions on brain images.
authors.affiliation: Department of Neurology, Helsinki University Central Hospital, Haartmaninkatu 4, 00290 Helsinki, Finland. elena.haapaniemi@hus.fi
authors.forename: Elena
authors.initials: E
authors.lastname: Haapaniemi
authors.forename: Johanna
authors.initials: J
authors.lastname: Helenius
authors.forename: Dimitrije
authors.initials: D
authors.lastname: Jakovljević
authors.forename: Lauri
authors.initials: L
authors.lastname: Soinne
authors.forename: Martti
authors.initials: M
authors.lastname: Syrjälä
authors.forename: Markku
authors.initials: M
authors.lastname: Kaste
authors.forename: Riitta
authors.initials: R
authors.lastname: Lassila
authors.forename: Turgut
authors.initials: T
authors.lastname: Tatlisumak
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000150:complications* / Q000235:genetics / Q000473:pathology; D020520:Brain Infarction / Q000235:genetics* / Q000473:pathology; D002545:Brain Ischemia / Q000235:genetics* / Q000473:pathology; D003324:Coronary Artery Disease / Q000150:complications* / Q000235:genetics / Q000473:pathology; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D016017:Odds Ratio; D010641:Phenotype; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D020521:Stroke / Q000235:genetics* / Q000473:pathology; D013927:Thrombosis / Q000150:complications / Q000235:genetics* / Q000473:pathology; D013997:Time Factors
chemical_list: C095381:factor V Leiden; D005165:Factor V