Cessation of HIV-1 transcription by inhibiting regulatory protein Rev-mediated RNA transport.
The HIV-1 Rev protein, which traffics through nucleolus and shuttles between nucleus and cytoplasm, facilitates export of unspliced and singly spliced viral transcripts containing RRE RNA by the CRM1 export pathway. Inhibitions of the various stages of Rev-mediated RNA transport can arrest HIV-1 transcriptional process. The current understanding to the mechanism of Rev function, Rev-RRE interaction, as well as inhibitors hereof is reviewed.
Cao
Yuan
Y
Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan, P.R. China. xinyongl@sdu.edu.cn.
Liu
Xinyong
X
De Clercq
Erik
E
D021581:Active Transport, Cell Nucleus; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D012367:RNA, Viral / Q000378:metabolism*; D014158:Transcription, Genetic; D014779:Virus Replication; D054321:rev Gene Products, Human Immunodeficiency Virus / Q000037:antagonists & inhibitors*
D012367:RNA, Viral; D054321:rev Gene Products, Human Immunodeficiency Virus; C514860:rev protein, Human Immunodeficiency Virus-1