New neolignan component from Camellia amplexicaulis and effects on osteoblast differentiation.
A new neolignan named "camellioside A" (1) has been isolated from the leaves and branches of Camellia amplexicaulis, along with seven known glycosides (2-8). Their structures were determined by a variety of spectroscopic analyses. Among them, compounds 2, 3, 4, and 6 significantly (p<0.05) increased the alkaline phosphatase activity and the mineralization of the nodules of the MC3T3-E1 osteoblastic cells compared to those of the control.
Tung
Nguyen Huu
NH
College of Pharmacy, Chungnam National University, Daejeon, Korea.
Ding
Yan
Y
Choi
Eun Mi
EM
Minh
Chau Van
CV
Kim
Young Ho
YH
D000818:Animals; D028244:Camellia; D002454:Cell Differentiation; D002460:Cell Line; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*
D017705:Lignans; D010936:Plant Extracts; C539585:camellioside A