title: Prevalence of migraine, tension-type headache and trigeminal neuralgia in multiple sclerosis.
abstract: BACKGROUND
  Prevalence rates of headache in multiple sclerosis (MS) patients varied widely in recent studies. This study aimed to investigate the 1 year prevalence of headache in MS compared with the general population.
  
  
  METHODS
  Population-based case-control study in Germany.
  
  
  RESULTS
  We included 491 patients with definite MS (68% female, mean age 45.3 years, 63.7% relapsing remitting MS, mean Expanded Disability Status Scale (EDSS) 3.2, 106 treated with interferon-beta, 53 with glatiramer acetate, 271 untreated) and 447 age and gender matched controls. Headache was diagnosed with a validated questionnaire according to the International Headache Society Criteria. Headache prevalence was 56.2% (tension type headache 37.2%, migraine 24.6%). Headache prevalence rates did not differ from controls. Headache was not associated with disability or treatment. Trigeminal neuralgia was found in 6.3% of MS cases.
  
  
  CONCLUSIONS
  Results suggest that headache in MS patients reflects comorbidity in most conditions.
authors.affiliation: Department of Neurology, University Hospital Essen, Essen, Germany. norman.putzki@uni-due.de
authors.forename: N
authors.initials: N
authors.lastname: Putzki
authors.forename: A
authors.initials: A
authors.lastname: Pfriem
authors.forename: V
authors.initials: V
authors.lastname: Limmroth
authors.forename: O
authors.initials: O
authors.lastname: Yaldizli
authors.forename: B
authors.initials: B
authors.lastname: Tettenborn
authors.forename: H C
authors.initials: HC
authors.lastname: Diener
authors.forename: Z
authors.initials: Z
authors.lastname: Katsarava
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D000068717:Glatiramer Acetate; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016899:Interferon-beta / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000453:epidemiology*; D009103:Multiple Sclerosis / Q000150:complications* / Q000188:drug therapy; D010455:Peptides / Q000627:therapeutic use; D015995:Prevalence; D018781:Tension-Type Headache / Q000150:complications / Q000453:epidemiology*; D014277:Trigeminal Neuralgia / Q000150:complications / Q000453:epidemiology*
chemical_list: D007166:Immunosuppressive Agents; D010455:Peptides; D000068717:Glatiramer Acetate; D016899:Interferon-beta