Mycangimycin, a polyene peroxide from a mutualist Streptomyces sp.
A mutualist actinomycete of the southern pine beetle, Dendroctonus frontalis, produces a polyene peroxide with pronounced antifungal activity. Its structure, absolute configuration, and biological activity were determined by spectral analysis, chemical modification followed by the modified Mosher method, and growth inhibitory assays, respectively.
Oh
Dong-Chan
DC
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Scott
Jarrod J
JJ
Currie
Cameron R
CR
Clardy
Jon
J
D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001517:Coleoptera / Q000382:microbiology; D015394:Molecular Structure; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D028223:Pinus; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*
D000085:Acetates; D000935:Antifungal Agents; D010545:Peroxides; D011090:Polyenes; C532356:mycangimycin