title: Chemotactic factors associated with eosinophilic gastrointestinal diseases.
abstract: The gastrointestinal (GI) tract is in constant negotiation with the microbial flora present in the lumen. Resident hematopoietic cells (ie, lymphocytes, mast cells, and eosinophils) are part of this ongoing and silent homeostatic battle. Eosinophilic GI diseases are characterized by an increased number of eosinophil infiltrates with no identified cause. This article describes the past and present knowledge regarding the chemotactic factors involved in GI eosinophilia.
authors.affiliation: Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, MLC 7028, Cincinnati, OH 45229-3039, USA.
authors.forename: Carine
authors.initials: C
authors.lastname: Blanchard
authors.forename: Marc E
authors.initials: ME
authors.lastname: Rothenberg
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002465:Cell Movement / Q000276:immunology; D018925:Chemokines / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D004802:Eosinophilia / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D051379:Mice; D019707:Receptors, Chemokine / Q000235:genetics / Q000378:metabolism*; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D018925:Chemokines; C512835:POSTN protein, human; D019707:Receptors, Chemokine