title: Epidemiological and clinical characteristics of methicillin sensitive Staphylococcus aureus (MSSA) bacteriuria.
abstract: OBJECTIVE
  To determine the frequency of MSSA bacteriuria in our hospital, ascertain nosocomial and community-acquired risk factors, identify specific epidemiological characteristics among bacteriuric patients with/without MSSA bacteremia.
  
  
  METHODS
  Adult patients with MSSA bacteriuria during 44 months identified retrospectively; their files reviewed for demographics, Charlson Comorbidity Index, urinary tract infection, clinical data, predisposing factors, urinary catheter data, treatment, and outcome.
  
  
  RESULTS
  106 patients (mean age 56 (SD 22) years; 43% females) with MSSA bacteriuria were identified, comprising 0.18% of bacteriurias in our hospital during the study period. Only 6.6% were admitted from long-term care facilities. 30% were hospital-acquired, with crude mortality rate 28% vs. 8% in community-acquired bacteriuria (P<0.05). Charlson Comorbidity Index was 2.7 (SD 3.2). 41% had a Foley urinary catheter. 12% with MSSA bacteriuria had concurrent MSSA bacteremia. In bacteremic patients vs. non-bacteremic patients: fever in 58% vs. 26% (P<0.025), antibiotics administered in 92% vs. 60% (P<0.04), and death by 28th post-discharge day 58% vs. 9% (P<0.001).
  
  
  CONCLUSIONS
  MSSA bacteriuria is rare, equally frequent in both genders, occurs in younger patients than previously described, and may occur even without a urinary catheter. Hospital-acquired bacteriuria and bacteremia are risk factors for mortality.
authors.affiliation: Infectious Diseases Institute, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel. saidelod@bgu.ac.il
authors.forename: Lisa
authors.initials: L
authors.lastname: Saidel-Odes
authors.forename: Klaris
authors.initials: K
authors.lastname: Riesenberg
authors.forename: Francisc
authors.initials: F
authors.lastname: Schlaeffer
authors.forename: Abraham
authors.initials: A
authors.lastname: Borer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001437:Bacteriuria / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality / Q000473:pathology*; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D015897:Comorbidity; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality / Q000473:pathology; D003710:Demography; D005260:Female; D006801:Humans; D008297:Male; D008712:Methicillin / Q000494:pharmacology; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality / Q000473:pathology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000302:isolation & purification*; D016896:Treatment Outcome; D014546:Urinary Catheterization / Q000706:statistics & numerical data; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D008712:Methicillin