Developing a tissue resource to characterize the genome of pancreatic cancer.
With recent advances in DNA sequencing technology, medicine is entering an era in which a personalized genomic approach to diagnosis and treatment of disease is feasible. However, discovering the role of altered DNA sequences in various disease states will be a challenging task. The genomic approach offers great promise for diseases, such as pancreatic cancer, in which the effect of current diagnostic and treatment modalities is disappointing. To facilitate the characterization of the genome of pancreatic cancer, high-quality and well-annotated tissue repositories are needed. This article summarizes the basic principles that guide the creation of such a repository, including sample processing and preservation techniques, sample size and composition, and collection of clinical data elements.
Voidonikolas
Georgios
G
Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA.
Gingras
Marie-Claude
MC
Hodges
Sally
S
McGuire
Amy L
AL
Chen
Changyi
C
Gibbs
Richard A
RA
Brunicardi
F Charles
FC
Fisher
William E
WE
D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics*; D019295:Computational Biology; D003219:Confidentiality; D030541:Databases, Genetic; D023281:Genomics; D006801:Humans; D007258:Informed Consent; D019188:Organ Preservation Solutions; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D011786:Quality Control; D013048:Specimen Handling; D014015:Tissue Banks / Q000331:legislation & jurisprudence / Q000458:organization & administration* / Q000592:standards; D014481:United States / Q000453:epidemiology
D019188:Organ Preservation Solutions