title: Expression of bone morphogenetic proteins, cartilage-derived morphogenetic proteins and related receptors in normal and osteoarthritic human articular cartilage.
abstract: Newborn and adult articular cartilage expresses bone (BMPs) and cartilage derived morphogenetic proteins (CDMPs). These morphogenetic proteins act over membrane receptors (BMPRs). We examined the expression pattern of BMP-7, BMP-3, CDMP-1, CDMP-2 and their receptors in adult normal and osteoarthritic, articular, knee cartilage. Immunostaining was carried out using polyclonal antibodies. The expression of BMP-7,-3, CDMP-1,-2 was detected in all layers of normal articular cartilage with the strongest expression in chondrocytes of the transitional layer. BMP-7 and CDMPs expression decreased in osteoarthritic articular cartilage whereas BMP-3 expression was absent. BMPR-IA and BMPR-II were strongly expressed in both normal and osteoarthritic articular cartilage. BMPR-IB was not expressed in osteoarthritic (OA) cartilage. BMPs and CDMPs with intact signalling play an important role in articular cartilage homeostasis, preventing cartilage degeneration.
authors.affiliation: Department of Anatomy, School of Medicine, University of Rijeka, Rijeka, Croatia.
authors.forename: Dragica
authors.initials: D
authors.lastname: Bobinac
authors.forename: Josip
authors.initials: J
authors.lastname: Spanjol
authors.forename: Marin
authors.initials: M
authors.lastname: Marinović
authors.forename: Sanja
authors.initials: S
authors.lastname: Zoricić Cvek
authors.forename: Ivana
authors.initials: I
authors.lastname: Marić
authors.forename: Tedi
authors.initials: T
authors.lastname: Cicvarić
authors.forename: Dora
authors.initials: D
authors.lastname: Fuckar
authors.forename: Dean
authors.initials: D
authors.lastname: Markić
authors.forename: Bozidar
authors.initials: B
authors.lastname: Vojniković
mesh_terms: D000328:Adult; D000368:Aged; D055398:Bone Morphogenetic Protein 3 / Q000378:metabolism; D055419:Bone Morphogenetic Protein 7 / Q000378:metabolism; D019485:Bone Morphogenetic Proteins / Q000378:metabolism*; D002102:Cadaver; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D055428:Growth Differentiation Factor 5 / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology; D020370:Osteoarthritis, Knee / Q000378:metabolism
chemical_list: D055398:Bone Morphogenetic Protein 3; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D055428:Growth Differentiation Factor 5; C090394:cartilage-derived-morphogenetic protein-2