[Changes in the toxicity and immunotoxity of tetrachloromethane and carbophos under the action of 2,4,6-triphenyl-4H-selenopyran and their connection with cytochrome P-450 dependent monooxygenase system].
It is established in experiments on noninbred rats that 2,4,6-triphenyl-4H-selenopyrane (peroral administration in a dose of 0.8 mg/kg during 3 days) induces cytochrome P450, thus increasing the toxicity and immunotoxicity of carbon tetrachloride (metabolized via "lethal synthesis"), and reduces the analogous effects of carbophos, the biotransformation of which proceeds via the formation of low-toxicity and nontoxic metabolites.
Zabrodskiĭ
P F
PF
Drevko
B I
BI
Mandych
V G
VG
Germanchuk
V G
VG
Balashov
S V
SV
Kuz'min
A V
AV
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001711:Biotransformation; D002251:Carbon Tetrachloride / Q000493:pharmacokinetics / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D007928:Lethal Dose 50; D008294:Malathion / Q000493:pharmacokinetics / Q000633:toxicity*; D008297:Male; D016566:Organoselenium Compounds / Q000494:pharmacology*; D051381:Rats
C535209:2,4,6-triphenyl-4H-selenopyran; D016566:Organoselenium Compounds; D003577:Cytochrome P-450 Enzyme System; D002251:Carbon Tetrachloride; D008294:Malathion