title: Probing the lactose.GM3 carbohydrate-carbohydrate interaction with glycodendrimers.
abstract: Multivalent glycoconjugates were prepared using generation-4 PAMAM dendrimers, and their interaction with Langmuir monolayers containing GM3 was investigated. Excessive carbohydrate valency adversely affects the carbohydrate-carbohydrate interaction. The GM3 monolayer selectively interacts with lactose-functionalized dendrimers in the presence of calcium ions.
authors.affiliation: Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
authors.forename: Nicole
authors.initials: N
authors.lastname: Seah
authors.forename: Paul V
authors.initials: PV
authors.lastname: Santacroce
authors.forename: Amit
authors.initials: A
authors.lastname: Basu
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D050091:Dendrimers / Q000737:chemistry*; D005679:G(M3) Ganglioside / Q000737:chemistry*; D006001:Glycoconjugates / Q000138:chemical synthesis* / Q000737:chemistry; D007785:Lactose / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D002241:Carbohydrates; D050091:Dendrimers; D005679:G(M3) Ganglioside; D006001:Glycoconjugates; D007785:Lactose