title: Structural bioinformatics of Vibrio cholerae aminopeptidase A (PepA) monomer.
abstract: Aminopeptidase A (PepA) is a metalloexopeptidase found in Vibrio cholerae .It functions as a transcriptional repressor in regulatory cascade that controls virulence gene expression in V. cholerae. It is involved in protein degradation and in the metabolism of biologically active peptides. We proposed a 3D model of PepA based upon the crystal structure of PepA from Escherichia coli (E. coli) with an intention to evaluate the active site of the enzyme and to predict the properties of this enzyme, study of its 3D structure will help in understanding its role in DNA binding.
authors.affiliation: Center of Biotechnology, University of Peshawar, Peshawar, Pakistan.
authors.forename: Ghosia
authors.initials: G
authors.lastname: Lutfullah
authors.forename: Noreen
authors.initials: N
authors.lastname: Azhar
authors.forename: Farhat
authors.initials: F
authors.lastname: Amin
authors.forename: Zahid
authors.initials: Z
authors.lastname: Khan
authors.forename: M Kamran
authors.initials: MK
authors.lastname: Azim
authors.forename: Khalida
authors.initials: K
authors.lastname: Shouqat
authors.forename: Sajid
authors.initials: S
authors.lastname: Noor
authors.forename: Rizwan
authors.initials: R
authors.lastname: Ali
mesh_terms: D000595:Amino Acid Sequence; D020134:Catalytic Domain; D019295:Computational Biology; D043384:Glutamyl Aminopeptidase / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D014734:Vibrio cholerae / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity
chemical_list: D043384:Glutamyl Aminopeptidase