[The role of a mitochondrial palmitate/Ca(2+)-activated pore in palmitate-induced apoptosis].
Evidence for the possible involvement of the mitochondrial cyclosporin A-insensitive palmitate/Ca(2+)-activated pore in the apoptotic process is presented. It has been established that the opening of palmitate/Ca(2+)-activated pore results in high-amplitude swelling of mitochondria and the release of apoptosis-induced factor from organelles. These processes are accompanied by a transitory small decrease of membrane potential, which recovers in 1 min. The possible role of palmitate/Ca(2+)-activated pore in the induction of palmitate-activated apoptosis is discussed.
Belosludtsev
K N
KN
Belosludtseva
N V
NV
Mironova
G D
GD
D000818:Animals; D017209:Apoptosis; D051033:Apoptosis Inducing Factor / Q000378:metabolism; D002118:Calcium / Q000502:physiology*; D003470:Culture Media; D066298:In Vitro Techniques; D053078:Membrane Potential, Mitochondrial; D008930:Mitochondria, Liver / Q000502:physiology*; D033681:Mitochondrial Membrane Transport Proteins / Q000502:physiology; D000083162:Mitochondrial Permeability Transition Pore; D024101:Mitochondrial Proteins / Q000502:physiology*; D019308:Palmitic Acid / Q000378:metabolism* / Q000494:pharmacology; D010710:Phosphates / Q000494:pharmacology; D051381:Rats
D051033:Apoptosis Inducing Factor; D003470:Culture Media; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D024101:Mitochondrial Proteins; D010710:Phosphates; D019308:Palmitic Acid; D002118:Calcium