title: The influence of calcium signaling on the regulation of alternative splicing.
abstract: In this review the influence of calcium signaling on the regulation of alternative splicing is discussed with respect to its influence on cell- and developmental-specific expression of different isoforms of the plasma membrane calcium pump (PMCA). In a second part the possibility is discussed that due to the interaction of the calcium-binding protein ALG-2 with a spliceosomal regulator of alternative splicing, RBM22, Ca2+-signaling may thus influence its regulatory property.
authors.affiliation: NMR-based Structural Biology, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. jkrebs@nmr.mpibpc.mpg.de
authors.forename: Joachim
authors.initials: J
authors.lastname: Krebs
mesh_terms: D017398:Alternative Splicing; D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling / Q000502:physiology*; D002135:Calcium-Binding Proteins / Q000235:genetics / Q000378:metabolism; D002460:Cell Line; D005786:Gene Expression Regulation; D006801:Humans; D008958:Models, Molecular; D053499:Plasma Membrane Calcium-Transporting ATPases / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D017433:Protein Structure, Secondary; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D002135:Calcium-Binding Proteins; D020033:Protein Isoforms; D016601:RNA-Binding Proteins; D053499:Plasma Membrane Calcium-Transporting ATPases; D002118:Calcium