title: A lysine walk to high relaxivity collagen-targeted MRI contrast agents.
abstract: A strategy for preparing peptide-based magnetic resonance contrast agents with multiple gadolinium chelates is described.
authors.affiliation: A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth St, Suite 2301, Charlestown, MA 02129, USA. caravan@nmr.mgh.harvard.edu
authors.forename: Peter
authors.initials: P
authors.lastname: Caravan
authors.forename: Biplab
authors.initials: B
authors.lastname: Das
authors.forename: Qing
authors.initials: Q
authors.lastname: Deng
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dumas
authors.forename: Vincent
authors.initials: V
authors.lastname: Jacques
authors.forename: Steffi K
authors.initials: SK
authors.lastname: Koerner
authors.forename: Andrew
authors.initials: A
authors.lastname: Kolodziej
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Looby
authors.forename: Wei-Chuan
authors.initials: WC
authors.lastname: Sun
authors.forename: Zhaoda
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000595:Amino Acid Sequence; D002851:Chromatography, High Pressure Liquid; D003094:Collagen / Q000378:metabolism*; D003287:Contrast Media / Q000138:chemical synthesis*; D019786:Gadolinium DTPA / Q000737:chemistry; D008239:Lysine / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D008969:Molecular Sequence Data; D013329:Structure-Activity Relationship
chemical_list: D003287:Contrast Media; D003094:Collagen; D019786:Gadolinium DTPA; D008239:Lysine