title: MYO9B polymorphisms in multiple sclerosis.
abstract: Single-nucleotide polymorphisms (SNPs) in the 3' region of myosin IXB (MYO9B) gene have recently been reported to associate with different inflammatory or autoimmune diseases. We monitored for the association of MYO9B variants to multiple sclerosis (MS) in four Northern European populations. First, 18 SNPs including 6 SNPs with previous evidence for association to immune disorders, were tested in 730 Finnish MS families, but no linkage or family-based association was observed. To ensure the power to detect variants with a modest effect size, we further analyzed 10 variants in 899 Finnish cases and 1325 controls, and in a total of 1521 cases and 1476 controls from Denmark, Norway and Sweden, but found no association. Our results thereby do not support a major function of the tested MYO9B variants in MS.
authors.affiliation: Department of Molecular Medicine, National Public Health Institute and Institute for Molecular Medicine Finland, FIMM, Helsinki, Finland.
authors.forename: Anu
authors.initials: A
authors.lastname: Kemppinen
authors.forename: Minna
authors.initials: M
authors.lastname: Suvela
authors.forename: Pentti J
authors.initials: PJ
authors.lastname: Tienari
authors.forename: Irina
authors.initials: I
authors.lastname: Elovaara
authors.forename: Keijo
authors.initials: K
authors.lastname: Koivisto
authors.forename: Tuula
authors.initials: T
authors.lastname: Pirttilä
authors.forename: Mauri
authors.initials: M
authors.lastname: Reunanen
authors.forename: Ilkka
authors.initials: I
authors.lastname: Rautakorpi
authors.forename: Jan
authors.initials: J
authors.lastname: Hillert
authors.forename: Frida
authors.initials: F
authors.lastname: Lundmark
authors.forename: Annette
authors.initials: A
authors.lastname: Oturai
authors.forename: Lars
authors.initials: L
authors.lastname: Ryder
authors.forename: Hanne F
authors.initials: HF
authors.lastname: Harbo
authors.forename: Elisabeth G
authors.initials: EG
authors.lastname: Celius
authors.forename: Aarno
authors.initials: A
authors.lastname: Palotie
authors.forename: Mark
authors.initials: M
authors.lastname: Daly
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: Janna
authors.initials: J
authors.lastname: Saarela
mesh_terms: D016022:Case-Control Studies; D005190:Family; D005838:Genotype; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D009218:Myosins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C113469:myosin IXB; D009218:Myosins