Blood flow in the peripapillary retina in exfoliation glaucoma.
OBJECTIVE
The aim of this article is to study peripapillary retinal blood flow in patients with progressive and stable exfoliation glaucoma (ExG).


METHODS
Fifty-eight eyes with ExG were included; 25 of them had progressive and 33 stable glaucoma. Retinal blood flow in the peripapillary retina was measured with scanning laser Doppler flowmetry. Acquired flow maps were analysed with the automatic full-field perfusion image analyser. Multiple logistic regression was used to model progression of glaucoma.


RESULTS
Mean retinal flow (MF; correlation coefficient, P-value; R = 0.36, P = 0.006) and retinal minimum diastolic flow (R = 0.33, P = 0.011) were positively correlated with visual field mean defect (MD). Factors associated with progressive glaucoma were mean intraocular pressure (OR = 1.198 for each mmHg; P = 0.050) and visual field MD (OR = 1.134 for each dB; P = 0.013). Age (P = 0.35), MF (P = 0.58), or presence of cardiovascular disease (P = 0.17) were not associated with glaucoma progression.


CONCLUSIONS
No difference in peripapillary retinal blood flow between progressive and stable ExG could be found.
Harju
Mika
M
Helsinki University Eye Hospital, Helsinki, Finland. mika.harju@aad.fi
Kurvinen
Leena
L
Saari
Jukka
J
Vesti
Eija
E
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D003430:Cross-Sectional Studies; D017889:Exfoliation Syndrome / Q000150:complications / Q000503:physiopathology*; D005901:Glaucoma / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure; D017078:Laser-Doppler Flowmetry; D008875:Middle Aged; D009898:Optic Disk / Q000503:physiopathology; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000503:physiopathology*; D014794:Visual Fields
D002317:Cardiovascular Agents