Catalyzed vinylogous Mukaiyama aldol reactions with controlled enantio- and diastereoselectivities.
In control: A new catalytic vinylogous Mukaiyama aldol reaction provides products with high diastereo- and enantioselectivities (up to 99 % de and ee; see scheme). The relative and absolute stereochemistry of a representative product was rigorously assigned by NMR and CD spectroscopies (measured and calculated), X-ray diffraction, and quantum-chemical calculations.
Frings
Marcus
M
Institut für Organische Chemie der RWTH Aachen University, Landoltweg 1, 52056 Aachen, Germany.
Atodiresei
Iuliana
I
Runsink
Jan
J
Raabe
Gerhard
G
Bolm
Carsten
C