title: In vitro solubility, stability and permeability of novel quercetin-amino acid conjugates.
abstract: In order to discover a quercetin prodrug with improved bioavailability, we synthesized nine quercetin-amion acid conjugates and estimated their pharmacokinetic properties including water solubility, stability against chemical or enzymatic hydrolysis, and cell permeability. Among the synthesized quercetin prodrugs, quercetin-glutamic acid conjugate Qu-E (4g/5g) showed remarkable increases in water solubility, stability, and cell permeability compared with quercetin, which warrants further development as a quercetin prodrug.
authors.affiliation: Department of Bioscience and Biotechnology, Konkuk University, Seoul 143-701, Republic of Korea.
authors.forename: Mi Kyoung
authors.initials: MK
authors.lastname: Kim
authors.forename: Kwang-su
authors.initials: KS
authors.lastname: Park
authors.forename: Woon-seok
authors.initials: WS
authors.lastname: Yeo
authors.forename: Hyunah
authors.initials: H
authors.lastname: Choo
authors.forename: Youhoon
authors.initials: Y
authors.lastname: Chong
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D000818:Animals; D002460:Cell Line; D004285:Dogs; D006207:Half-Life; D010539:Permeability; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D011794:Quercetin / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics*; D012995:Solubility
chemical_list: D000596:Amino Acids; D011355:Prodrugs; D011794:Quercetin