title: Ag-doped manganite nanoparticles: new materials for temperature-controlled medical hyperthermia.
abstract: The purpose of this study was to introduce newly synthesized nanomaterials as an alternative to superparamagnetic ironoxide based particles (SPIO) and thus to launch a new platform for highly controllable hyperthermia cancer therapy and imaging. The new material that forms the basis for this article is lanthanum manganite particles with silver ions inserted into the perovskite lattice: La(1-x)Ag(x)MnO(3+delta). Adjusting the silver doping level, it is possible to control the Curie temperature (T(c)) in the hyperthermia range of interest (41-44 degrees C). A new class of nanoparticles based on silver-doped manganites La(1-x)Ag(x)MnO(3+delta) is suggested. New nanoparticles are stable, and their properties were not affected by the typical ambient conditions in the living tissue. It is possible to monitor the particle uptake and retention by MRI. When these particles are placed into an alternating magnetic field, their temperature increases to the definite value near T(c) and then remains constant if the magnetic field is maintained. During the hyperthermia procedure, the temperature can be restricted, thereby preventing the necrosis of normal tissue. A new class of nanoparticles based on silver-doped manganites La(1-x)Ag(x)MnO(3+delta) was suggested. Ag-doped perovskite manganites particles clearly demonstrated the effect of adjustable Curie temperature necessary for highly controllable cellular hyperthermia. The magnetic relaxation properties of the particles are comparable with that of SPIO, and so we were able to monitor the particle movement and retention by MRI. Thus, the new material combines the MRI contrast enhancement capability with targeted hyperthermia treatment.
authors.affiliation: Chemistry Department, Moscow State University, 119991 Moscow, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Melnikov
authors.forename: O Yu
authors.initials: OY
authors.lastname: Gorbenko
authors.forename: M N
authors.initials: MN
authors.lastname: Markelova
authors.forename: A R
authors.initials: AR
authors.lastname: Kaul
authors.forename: V A
authors.initials: VA
authors.lastname: Atsarkin
authors.forename: V V
authors.initials: VV
authors.lastname: Demidov
authors.forename: C
authors.initials: C
authors.lastname: Soto
authors.forename: E J
authors.initials: EJ
authors.lastname: Roy
authors.forename: B M
authors.initials: BM
authors.lastname: Odintsov
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001921:Brain / Q000166:cytology / Q000187:drug effects; D004560:Electricity; D005290:Ferric Compounds / Q000494:pharmacology; D006979:Hyperthermia, Induced / Q000379:methods*; D008279:Magnetic Resonance Imaging; D017895:Manganese Compounds / Q000494:pharmacology*; D008422:Materials Testing / Q000379:methods*; D051379:Mice; D017628:Microglia / Q000166:cytology / Q000187:drug effects; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D012834:Silver / Q000494:pharmacology*; D013696:Temperature; D044366:Transition Temperature
chemical_list: D001672:Biocompatible Materials; D005290:Ferric Compounds; D017895:Manganese Compounds; C494384:manganite; C000499:ferric oxide; D012834:Silver