title: Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity.
abstract: BACKGROUND
  The understanding of the epidemiology of severe malaria in African children remains incomplete across the spectrum of Plasmodium falciparum transmission intensities through which communities might expect to transition, as intervention coverage expands.
  
  
  METHODS
  Paediatric admission data were assembled from 13 hospitals serving 17 communities between 1990 and 2007. Estimates of Plasmodium falciparum transmission intensity in these communities were assembled to be spatially and temporally congruent to the clinical admission data. The analysis focused on the relationships between community derived parasite prevalence and the age and clinical presentation of paediatric malaria in children aged 0-9 years admitted to hospital.
  
  
  RESULTS
  As transmission intensity declined a greater proportion of malaria admissions were in older children. There was a strong linear relationship between increasing transmission intensity and the proportion of paediatric malaria admissions that were infants (R2 = 0.73, p < 0.001). Cerebral malaria was reported among 4% and severe malaria anaemia among 17% of all malaria admissions. At higher transmission intensity cerebral malaria was a less common presentation compared to lower transmission sites. There was no obvious relationship between the proportions of children with severe malaria anaemia and transmission intensity.
  
  
  CONCLUSIONS
  As the intensity of malaria transmission declines in Africa through the scaling up of insecticide-treated nets and other vector control measures a focus of disease prevention among very young children becomes less appropriate. The understanding of the relationship between parasite exposure and patterns of disease risk should be used to adapt malaria control strategies in different epidemiological settings.
authors.affiliation: Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI-Wellcome Trust Collaborative Programme, Kenyatta National Hospital Grounds PO Box 43640-00100, Nairobi, Kenya. eokiro@nairobi.kemri-wellcome.org
authors.forename: Emelda A
authors.initials: EA
authors.lastname: Okiro
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al-Taiar
authors.forename: Hugh
authors.initials: H
authors.lastname: Reyburn
authors.forename: Richard
authors.initials: R
authors.lastname: Idro
authors.forename: James A
authors.initials: JA
authors.lastname: Berkley
authors.forename: Robert W
authors.initials: RW
authors.lastname: Snow
mesh_terms: D000349:Africa / Q000453:epidemiology; D017677:Age Distribution; D000367:Age Factors; D000818:Animals; D002648:Child; D002675:Child, Preschool; D019353:Endemic Diseases / Q000517:prevention & control / Q000706:statistics & numerical data*; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000469:parasitology / Q000635:transmission*; D008297:Male; D010963:Plasmodium falciparum / Q000472:pathogenicity*; D011159:Population Surveillance; D015995:Prevalence