Two novel MICA alleles, MICA*054 and MICA*056.
We report the identification of two novel major histocompatibility complex (MHC) class I-related chain A (MICA) alleles. MICA*054 has a nucleotide substitution of A to G at position 871 (codon 268), encoding an amino acid change of serine to glycine in the alpha-3 domain. MICA*056 has a nucleotide substitution at position 758 of G to C resulting in the substitution of tryptophan for serine at codon 230, also in the alpha-3 domain.
Cox
S T
ST
The Anthony Nolan Research Institute and Trust, The Royal Free Hospital, London, UK. steven.cox@anthonynolan.org.uk
Stephens
H A F
HA
Fernando
R
R
Grant
J
J
Madrigal
J A
JA
Little
A-M
AM
D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics*; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment
D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A