title: Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network.
abstract: Tonic motor control involves oscillatory synchronization of activity at low frequency (5-30 Hz) throughout the sensorimotor system, including cerebellar areas. We investigated the mechanisms underpinning cerebellar oscillations. We found that Golgi interneurons, which gate information transfer in the cerebellar cortex input layer, are extensively coupled through electrical synapses. When depolarized in vitro, these neurons displayed low-frequency oscillatory synchronization, imposing rhythmic inhibition onto granule cells. Combining experiments and modeling, we show that electrical transmission of the spike afterhyperpolarization is the essential component for oscillatory population synchronization. Rhythmic firing arises in spite of strong heterogeneities, is frequency tuned by the mean excitatory input to Golgi cells, and displays pronounced resonance when the modeled network is driven by oscillating inputs. In vivo, unitary Golgi cell activity was found to synchronize with low-frequency LFP oscillations occurring during quiet waking. These results suggest a major role for Golgi cells in coordinating cerebellar sensorimotor integration during oscillatory interactions.
authors.affiliation: Laboratoire de Neurobiologie, ENS, CNRS, Paris.
authors.forename: Guillaume P
authors.initials: GP
authors.lastname: Dugué
authors.forename: Nicolas
authors.initials: N
authors.lastname: Brunel
authors.forename: Vincent
authors.initials: V
authors.lastname: Hakim
authors.forename: Eric
authors.initials: E
authors.lastname: Schwartz
authors.forename: Mireille
authors.initials: M
authors.lastname: Chat
authors.forename: Maxime
authors.initials: M
authors.lastname: Lévesque
authors.forename: Richard
authors.initials: R
authors.lastname: Courtemanche
authors.forename: Clément
authors.initials: C
authors.lastname: Léna
authors.forename: Stéphane
authors.initials: S
authors.lastname: Dieudonné
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000818:Animals; D002531:Cerebellum / Q000166:cytology* / Q000502:physiology; D054351:Electrical Synapses / Q000502:physiology*; D018690:Excitatory Amino Acid Agonists / Q000378:metabolism; D007395:Interneurons / Q000166:cytology / Q000502:physiology*; D007608:Kainic Acid / Q000378:metabolism; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology; D018408:Patch-Clamp Techniques; D010507:Periodicity
chemical_list: D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid