Vegetable, fruit and antioxidant nutrient consumption and subsequent risk of hepatocellular carcinoma: a prospective cohort study in Japan.
In a population-based prospective study of 19,998 Japanese individuals, consumption of vegetables, green-yellow and green leafy vegetables was inversely associated with the risk of hepatocellular carcinoma (101 cases), with multivariable hazard ratios for the highest vs lowest tertile of 0.61 (95% confidence interval (CI)=0.36-1.03, P(trend)=0.07), 0.65 (95% CI=0.39-1.08, P(trend)=0.06) and 0.59 (95% CI=0.35-1.01, P(trend)=0.04), respectively.
Kurahashi
N
N
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center 5-1-1, Tsukiji Chuo-ku, Tokyo 104-0045, Japan. nkurahas@ncc.go.jp
Inoue
M
M
Iwasaki
M
M
Tanaka
Y
Y
Mizokami
M
M
Tsugane
S
S
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000517:prevention & control*; D015331:Cohort Studies; D005260:Female; D005638:Fruit; D006801:Humans; D008113:Liver Neoplasms / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk; D014675:Vegetables
D000975:Antioxidants; D001205:Ascorbic Acid