Tetrahydrofuran acetogenins from Laurencia glandulifera.
Five new C(15) acetogenin en-ynes (1-5) with a rare tetrahydrofuran moiety and a linear biosynthetic precursor (6) were isolated from an organic extract of Laurencia glandulifera, collected from the island of Crete in the south Aegean Sea. The structures of the new natural products, as well as their relative configuration, were established by means of spectroscopic data analysis. The cytotoxicity of the isolated natural products was evaluated against five human tumor cell lines.
Kladi
Maria
M
Department of Pharmacognosy and Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
Vagias
Constantinos
C
Papazafiri
Panagiota
P
Brogi
Simone
S
Tafi
Andrea
A
Roussis
Vassilios
V
D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006115:Greece; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D044722:Laurencia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D054378:Acetogenins; D000480:Alkynes; D005663:Furans; C018674:tetrahydrofuran