title: Label-free DNA biosensors based on functionalized carbon nanotube field effect transistors.
abstract: A carbon nanotube transistor array was used to detect DNA hybridization. A new approach to ensure specific adsorption of DNA to the nanotubes was developed. The polymer poly (methylmethacrylate(0.6)-co-poly(ethyleneglycol)methacrylate(0.15)-co-N-succinimidyl methacrylate(0.25)) was synthesized and bonded noncovalently to the nanotube. Aminated single-strand DNA was then attached covalently to the polymer. After hybridization, statistically significant changes were observed in key transistor parameters. Hybridized DNA traps both electrons and holes, possibly caused by the charge-trapping nature of the base pairs.
authors.affiliation: Instituto de Carboquímica, Miguel Luesma, 4 Zaragoza, Spain.
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Martinez
authors.forename: Yu-Chih
authors.initials: YC
authors.lastname: Tseng
authors.forename: Nerea
authors.initials: N
authors.lastname: Ormategui
authors.forename: Iraida
authors.initials: I
authors.lastname: Loinaz
authors.forename: Ramon
authors.initials: R
authors.lastname: Eritja
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bokor
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000032:analysis* / Q000737:chemistry*; D015342:DNA Probes / Q000032:analysis* / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D015394:Molecular Structure; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D014173:Transistors, Electronic
chemical_list: D015342:DNA Probes; D037742:Nanotubes, Carbon; D004247:DNA