Correlation between characteristics of unrelated bone marrow donor and cell density of total nucleated cell in bone marrow harvest.
The relationship between the features of bone marrow donor and the quality of marrow harvest has been unclear because most of bone marrow registries have multiple collection centers with somewhat different harvest procedures. We are able to address this issue for Tzu Chi General Hospital is the only collection center affiliated with Tzu Chi Taiwan Bone Marrow Registry. Between November 1997 and March 2002, data of 286 healthy unrelated donors was analyzed to correlate with the cell density of total nucleated cell in bone marrow harvests. The harvest procedure was standardized by single-hole harvest needle under general anesthesia. The operation staffs were restricted within the members of Oncology-Hematology division. The results showed that the cell density of bone marrow harvest was positively correlated with donor body weight and peripheral white blood cell count P = 0.0475, P < 0.0001, but negatively correlated with the total volume of bone marrow harvest P < 0.0001. We recommend that if multiple human leukocyte antigen-matched donors are available, donor with higher body weight and/or higher white blood cell count be selected for allogeneic bone marrow transplantation.
Kao
Ruey-Ho
RH
Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan. rueyhokao@tzuchi.org.tw.|Department of Oncology, Tzu Chi University, Hualien, Taiwan. rueyhokao@tzuchi.org.tw.
Li
Chi-Cheng
CC
Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan.|Department of Oncology, Tzu Chi University, Hualien, Taiwan.
Shaw
Cheng-Kuang
CK
Department of Public Health, Tzu Chi University, Hualien, Taiwan.
Wang
Tso-Fu
TF
Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan.
Chu
Sung-Chao
SC
Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan.
Chen
Shu-Huey
SH
Department of Paediatrics, Tzu Chi General Hospital, Hualien, Taiwan.|Buddhist Tzu Chi Stem Cells Center, Hualien, Taiwan.
Yao
Chao-Yuan
CY
Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan.
Huang
Kuan-Po
KP
Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan.
Wu
Yi-Feng
YF
Department of Oncology-Hematology, Tzu Chi General Hospital, 707 Section 3 Chung Yang Road, Hualien, 970, Taiwan.
D001835:Body Weight; D001853:Bone Marrow; D001854:Bone Marrow Cells / Q000166:cytology; D016026:Bone Marrow Transplantation / Q000379:methods; D002452:Cell Count; D046148:Donor Selection / Q000379:methods*; D006801:Humans; D011786:Quality Control