title: Effect of clarithromycin on the pharmacokinetics of pranlukast in healthy volunteers.
abstract: Pranlukast is a cysteinyl leukotriene receptor antagonist that has been used to treat bronchial asthma and allergic rhinitis. In vitro data suggest that pranlukast is a substrate of CYP3A4. Thus, the effect of clarithromycin, a potent CYP3A4 inhibitor, on the pharmacokinetics of pranlukast was examined in an open-label, randomized, two-way crossover study in 16 healthy male volunteers. In treatment A, volunteers received a single, 225 mg dose of pranlukast. In treatment B, 200 mg of clarithromycin was administered twice daily for 7 days and a single, 225 mg dose of pranlukast was coadministered on day 7. Blood samples were collected up to 24 hours after treatment, and pranlukast concentrations in the plasma were measured. The geometric mean ratios [GMR] (90% confidence intervals [CIs]) for pranlukast AUC(0-infinity) and C(max) (with/without clarithromycin) were 1.06 (0.91, 1.24) and 1.17 (0.95, 1.45), respectively. In conclusion, clarithromycin and pranlukast could be coadministered without dose adjustment because clarithromycin minimally affected the pharmacokinetics of pranlukast.
authors.affiliation: Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co., Ltd., Ibaraki, Japan. s.nakade@ono.co.jp
authors.forename: Susumu
authors.initials: S
authors.lastname: Nakade
authors.forename: Akinori
authors.initials: A
authors.lastname: Yamauchi
authors.forename: Junji
authors.initials: J
authors.lastname: Komaba
authors.forename: Tomoya
authors.initials: T
authors.lastname: Ohno
authors.forename: Junsaku
authors.initials: J
authors.lastname: Kitagawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Honda
authors.forename: Chihiro
authors.initials: C
authors.lastname: Hasegawa
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yoneda
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Kodama
authors.forename: Kuninobu
authors.initials: K
authors.lastname: Yasuda
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Miyata
mesh_terms: D000328:Adult; D002867:Chromones / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D017291:Clarithromycin / Q000008:administration & dosage* / Q000009:adverse effects / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: D002867:Chromones; D017291:Clarithromycin; C047681:pranlukast