Obesity and vascular risk.
Obesity is a common disorder and a known risk factor for vascular thrombotic complications. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. Studies using a nutritionally induced obesity model in transgenic mice support a role of the fibrinolytic (plasminogen/plasmin) and matrix metalloproteinase (MMP) systems in these processes. Venous or arterial thrombosis models in obese mice confirm a prothrombotic risk associated with obesity.
Lijnen
H R
HR
Center for Molecular and Vascular Biology, KU Leuven, Campus Gasthuisberg, 3000 Leuven, Belgium. roger.lijnen@med.kuleuven.be
D000273:Adipose Tissue / Q000503:physiopathology; D000818:Animals; D001777:Blood Coagulation; D001783:Blood Flow Velocity; D004195:Disease Models, Animal; D005342:Fibrinolysis / Q000502:physiology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000235:genetics; D013927:Thrombosis / Q000097:blood / Q000453:epidemiology*; D010959:Tissue Plasminogen Activator / Q000172:deficiency / Q000235:genetics; D014568:Urokinase-Type Plasminogen Activator / Q000172:deficiency / Q000235:genetics; D014652:Vascular Diseases / Q000209:etiology* / Q000235:genetics
D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator; D020782:Matrix Metalloproteinases