Identification of a new HLA-B*40 allele, HLA-B*4081, in a Chinese individual.
A novel human leukocyte antigen (HLA)-B*40 allele, officially named B*4081, was identified during routine high-resolution sequence-based typing in a Chinese potential hematopoietic stem cell transplantation donor. The HLA-B*4081 allele shows one nucleotide difference from B*400101 in exon 2 at nucleotide position 124 where G-->C (codon 18 GGG-->CGG) resulting in a coding change, 18Gly is changed to Arg, this is a unique nucleotide change among the HLA class I alleles, suggesting a point mutation mechanism.
Zou
H-Y
HY
Immunogenetic Laboratory, Shenzhen Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong, China.
Li
Z
Z
Cheng
L-H
LH
Wang
D-M
DM
Deng
Z-H
ZH
D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence; D002681:China; D005091:Exons / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics*; D059947:HLA-B40 Antigen; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D019520:Living Donors; D008297:Male; D008969:Molecular Sequence Data; D017354:Point Mutation / Q000235:genetics; D016415:Sequence Alignment
D015235:HLA-B Antigens; C538922:HLA-B*40:81 antigens; D059947:HLA-B40 Antigen