title: Anti human immunodeficiency virus-1 (HIV-1) agents 1. Discovery of benzyl phenyl ethers as new HIV-1 inhibitors in vitro.
abstract: Ten single benzyl phenyl ethers were synthesized and evaluated as human immunodeficiency virus-1 (HIV-1) inhibitors in vitro for the first time. Among these compounds, especially 4-nitrobenzyl phenyl ether (3h) exhibited the highest anti-HIV-1 activity with EC50 (concentration of drug that reduces syncytia formation by 50%) value of 5.96 microg/ml and therapeutic index value of 18.32. The preliminary structure-activity relationships of these benzyl phenyl ethers were also described.
authors.affiliation: Laboratory of Pharmaceutical Synthesis, College of Sciences, Northwest A&F University, Yangling, China.
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Dai
authors.forename: Wu-Qing
authors.initials: WQ
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Xu
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Min
authors.initials: M
authors.lastname: Lv
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D010647:Phenyl Ethers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D019380:Anti-HIV Agents; D010647:Phenyl Ethers; C076624:dibenzyl ether