Enantioselective intermolecular crossed-conjugate additions between nitroalkenes and alpha,beta-enals through a dual activation strategy.
Double the fun: The title reaction was developed by using a Lewis base/iminium activation strategy (see scheme). The reaction proceeded with excellent yields and ee values, and the products were additionally transformed into a single enantiomer of a substituted pyrrolidine with excellent retention of configuration.
Zhong
Cheng
C
C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, WV 26506, USA.
Chen
Yunfeng
Y
Petersen
Jeffrey L
JL
Akhmedov
Novruz G
NG
Shi
Xiaodong
X