Biorheological properties of reconstructed erythrocytes and its function of carrying-releasing oxygen.
Erythrocyte shape and biomechanical properties have close relation to its physiological function. In this research the erythrocyte was reconstructed with natural structure protein and lipids based on cellular mechanics and hemorheology concepts. The biomechanical properties of the reconstructed erythrocyte were determined with the micropipette aspiration system. The shapes of reconstructed erythrocyte were obtained with electron scanning microscope. The oxygen carrying-releasing function was analyzed with the HEMOX analyzer from TCS, the experimental results indicated that the reconstructed erythrocytes were similar to the natural erythrocyte: having biconcave disc shape, good deformability and carrying-releasing oxygen function.
Wang
Xiang
X
College of Bioengineering, Chongqing University, Chongqing, PR China. xwangchn@vip.sina.com
Gao
Wei
W
Peng
Weiyan
W
Xie
Jiaxin
J
Li
Yaojin
Y
D001802:Blood Substitutes / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism* / Q000648:ultrastructure*; D006470:Hemorrhage; D006801:Humans; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000378:metabolism*; D012212:Rheology
D001802:Blood Substitutes; D010100:Oxygen