Thromboangiitis obliterans with multiple large vessel involvement: case report and analysis of immunophenotypes.
Thromboangiitis obliterans (TAO, Buerger's disease) is an idiopathic, recurrent, segmental, nonatherosclerotic, inflammatory, occlusive vascular disease with a poorly understood pathogenesis. Intestinal or multi-organ involvement is rare. Recent immunohistochemical analyses of ordinary TAO have indicated an inflammatory and immunologic pathogenesis. We report a case of TAO involving multiple large vessels. By immunohistochemistry, CD3+ T cells were revealed around the recanalization sites within the abdominal aorta. CD4+ T cells were almost equal in number to CD8+ T cells. These findings indicate the participation of inflammatory and immunologic processes in TAO with multi-organ involvement (as in ordinary TAO).
Edo
Naoki
N
Department of Pathology and Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan.
Miyai
Kosuke
K
Ogata
Sho
S
Nakanishi
Kuniaki
K
Hiroi
Sadayuki
S
Tominaga
Susumu
S
Aiko
Satoshi
S
Kawai
Toshiaki
T
D017809:Fatal Outcome; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D012907:Smoking; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013919:Thromboangiitis Obliterans / Q000276:immunology* / Q000473:pathology* / Q000503:physiopathology