Associations of polymorphism within the GHSR gene with growth traits in Nanyang cattle.
GH secretagogue receptor (ghrelin receptor, GHSR) is known to be involved in the control of GH release by mediating the strong stimulatory effect of the endogenous ligand, ghrelin, on GH secretion. Associations between the GHSR gene polymorphism and the growth traits were revealed in Nanyang cattle. The mutations at nt456(G > A) and nt667(C > T) were complete linkage and located in exon 1 of the coding region of the GHSR gene. Least squares analysis revealed a significant statistical effect (P < 0.05) of the GHSR gene different genotypes on body weight and average daily gain at 6 months of age in Nanyang cattle. Individuals with GHSR-MM genotype showed higher body weight and average daily gain than individuals with GHSR-MN genotype.
Zhang
Bao
B
College of Animal Science and Technology, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Northwest A&F University, 712100 Yangling, Shaanxi, China. zhangbao_1983@yahoo.com.cn
Chen
Hong
H
Guo
Yikun
Y
Zhang
Liangzhi
L
Zhao
Miao
M
Lan
Xianyong
X
Zhang
Chunlei
C
Pan
Chuanying
C
Hu
Shenrong
S
Wang
Juqiang
J
Lei
Chuzhao
C
D000818:Animals; D001835:Body Weight; D001947:Breeding; D002417:Cattle / Q000235:genetics* / Q000254:growth & development; D002681:China; D056726:Genetic Association Studies / Q000379:methods; D016018:Least-Squares Analysis; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D018807:Polymorphism, Single-Stranded Conformational; D054440:Receptors, Ghrelin / Q000235:genetics*
D054440:Receptors, Ghrelin