title: Normalization of pH level and gastric mucosa after eradication of H. pylori in the remnant stomach.
abstract: BACKGROUND
  The Updated Sydney System (USS) is used to evaluate chronic gastritis and chronic atrophic gastritis (CAG) due to H. pylori infection. Here, we investigated USS scores and gastric juice pH levels in H. pylori infection-positive or -eradicated patients with remnant stomach after surgery.
  
  
  METHODS
  Gastric juice pH levels were measured using pH test-tape in 197 patients (112 H. pylori-positive and 85 H. pylori-negative after eradication) who had undergone distal gastrectomy and conventional H. pylori eradication therapy.
  
  
  RESULTS
  In H. pylori infection-positive remnant stomach cases, gastric juice pH showed a reverse correlation with pepsinogen I/II ratio, and H. pylori infection-negative patients following eradication showed associations with the degree of atrophy and intestinal metaplasia at both the anastomosis and in the corpus. Further, pH levels in these patients were normalized time depending after the eradication in the remnant stomach.
  
  
  CONCLUSIONS
  Eradication therapy for the remnant stomach contributes to the possible improvement of stomach conditions by controlling the pH level of gastric juice. This effect will be protective against the risk of secondary stomach carcinogenesis in the remnant stomach.
authors.affiliation: Department of Surgery, Nippon Medical School, Bunkyo-ku, Tokyo, Japan. katoshun@nms.ac.jp
authors.forename: Shunji
authors.initials: S
authors.lastname: Kato
authors.forename: Norio
authors.initials: N
authors.lastname: Matsukura
authors.forename: Noriko
authors.initials: N
authors.lastname: Matsuda
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Zenya
authors.initials: Z
authors.lastname: Naito
authors.forename: Takashi
authors.initials: T
authors.lastname: Tajiri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D005743:Gastrectomy; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D018530:Gastric Stump; D005757:Gastritis, Atrophic / Q000378:metabolism / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000378:metabolism / Q000382:microbiology / Q000473:pathology / Q000628:therapy*; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000032:analysis; D020115:Pepsinogen C / Q000032:analysis; D012720:Severity of Illness Index; D013274:Stomach Neoplasms / Q000382:microbiology / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D020115:Pepsinogen C; D020116:Pepsinogen A