title: Herpes simplex virus: a histopathologic study of the depth of herpetic wounds.
abstract: BACKGROUND
  Herpes is a prevalent, infectious disease that can occur anywhere on the body; it is found primarily on the face and genitalia. Herpes simplex virus type 1 (HSV-1) and herpes simplex virus type 2 (HSV-2) are the DNA viruses that cause human herpes. Clinically, HSV-1 and HSV-2 infections produce lesions generally located on the mucocutaneous junctions of the face and genitalia. At times, vesicular lesions may ulcerate, leaving recalcitrant wounds that are challenging to treat. Until now, the basis of treatment has been related to the eradication of the viral infection. Little attention has focused on the consequence of the viral infection and the resulting wounds, specifically whether this represents an epidermal or dermal injury.
  
  
  METHODS
  Using 10 herpetic lesions from different individuals, we studied the depth of the injury via routine hematoxylin and eosin stains, as well as periodic acid-Schiff (PAS) and type IV collagen stains, which demonstrate the presence of the basement membrane.
  
  
  RESULTS
  In all cases, we found an inflammatory infiltrate in the dermis and selective disruption of the basement membrane.
  
  
  CONCLUSIONS
  This suggests that herpetic lesions involve the dermis and are best classified as partial-thickness wounds.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, Florida 33101, USA.
authors.forename: Asha R
authors.initials: AR
authors.lastname: Patel
authors.forename: Paolo
authors.initials: P
authors.lastname: Romanelli
authors.forename: Brenda
authors.initials: B
authors.lastname: Roberts
authors.forename: Robert S
authors.initials: RS
authors.lastname: Kirsner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D005260:Female; D006558:Herpes Genitalis / Q000473:pathology; D006560:Herpes Labialis / Q000473:pathology; D006561:Herpes Simplex / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018139:Simplexvirus / Q000302:isolation & purification*; D012883:Skin Ulcer / Q000473:pathology* / Q000821:virology*; D014945:Wound Healing / Q000502:physiology; D014947:Wounds and Injuries / Q000473:pathology / Q000821:virology