Structure and substrate specificity of acetyltransferase ACIAD1637 from Acinetobacter baylyi ADP1.
Gene ACIAD1637 from Acinetobacter baylyi ADP1 encodes a 182 amino acid putative antibiotic resistance protein. The structure of this protein (termed acepita) has been solved in space group P(2) to 2.35 A resolution. Acepita belongs to the GCN5-related N-acetyltransferase (GNAT) family, and contains the four sequence motifs conserved among family members. The structure of acepita is compared with that of pita, its homologue from Pseudomonas aeruginosa. Acepita has a similar substrate profile to pita and performs a similar function.
Davies
Anna M
AM
King's College London, Randall Division of Cell and Molecular Biophysics, London, SE1 1UL, UK.
Tata
Renée
R
Snape
Alison
A
Sutton
Brian J
BJ
Brown
Paul R
PR
D000123:Acetyltransferases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000150:Acinetobacter / Q000201:enzymology* / Q000378:metabolism; D000595:Amino Acid Sequence; D020134:Catalytic Domain / Q000502:physiology*; D003460:Crystallization; D007700:Kinetics; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009154:Mutation / Q000235:genetics; D016415:Sequence Alignment; D013379:Substrate Specificity / Q000502:physiology
D000123:Acetyltransferases