title: Ethanol intake and the risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC).
abstract: OBJECTIVE
  To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC).
  
  
  METHODS
  Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes.
  
  
  RESULTS
  Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption.
  
  
  CONCLUSIONS
  These results suggest no association of alcohol consumption with the risk of pancreatic cancer.
authors.affiliation: Division of Clinical Epidemiology, German Cancer Research Centre, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany. s.rohrmann@dkfz.de
authors.forename: Sabine
authors.initials: S
authors.lastname: Rohrmann
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Alina
authors.initials: A
authors.lastname: Vrieling
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Rachael Z
authors.initials: RZ
authors.lastname: Stolzenberg-Solomon
authors.forename: Albert B
authors.initials: AB
authors.lastname: Lowenfels
authors.forename: Majken K
authors.initials: MK
authors.lastname: Jensen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Anja
authors.initials: A
authors.lastname: Olsen
authors.forename: Anne
authors.initials: A
authors.lastname: Tjonneland
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Francoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: G
authors.initials: G
authors.lastname: Fagherazzi
authors.forename: Gesthimani
authors.initials: G
authors.lastname: Misirli
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Manuela M
authors.initials: MM
authors.lastname: Bergmann
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Naomi
authors.initials: N
authors.lastname: Allen
authors.forename: Andrew
authors.initials: A
authors.lastname: Roddam
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Valeria
authors.initials: V
authors.lastname: Pala
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Petra H M
authors.initials: PH
authors.lastname: Peeters
authors.forename: Anette
authors.initials: A
authors.lastname: Hjartåker
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Ma Luisa
authors.initials: ML
authors.lastname: Redondo Cornejo
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.forename: Larraitz
authors.initials: L
authors.lastname: Arriola
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: María-José
authors.initials: MJ
authors.lastname: Tormo
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte Gurrea
authors.forename: Björn
authors.initials: B
authors.lastname: Lindkvist
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Johansson
authors.forename: Weimin
authors.initials: W
authors.lastname: Ye
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Duell
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Dominique S
authors.initials: DS
authors.lastname: Michaud
authors.forename: Traci
authors.initials: T
authors.lastname: Mouw
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000453:epidemiology*; D016016:Proportional Hazards Models; D012307:Risk Factors