title: Design, synthesis and hypolipidemic activity of novel 2-(m-tolyloxy) isobutyric acid derivatives.
abstract: Novel 2-substituted isobutyric acid derivatives were synthesized and their hypolipidemic activity was evaluated in high cholesterol diet fed rat model. The amide 5a was found to decrease the levels of serum total cholesterol, LDL cholesterol and triglycerides in hyperlipidemic rats to a greater degree than the reference gemfibrozil.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, 47 Adnan El-Malky, 61519 Minia, Egypt.
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Idrees
authors.forename: Gamal el-Din A
authors.initials: Gel-D
authors.lastname: Abuo-Rahma
authors.forename: Omar M
authors.initials: OM
authors.lastname: Aly
authors.forename: Mohamed F
authors.initials: MF
authors.lastname: Radwan
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D004195:Disease Models, Animal; D015195:Drug Design; D015248:Gemfibrozil / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D011422:Propionates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013237:Stereoisomerism; D014280:Triglycerides / Q000097:blood
chemical_list: D002791:Cholesterol, Dietary; D000960:Hypolipidemic Agents; D011422:Propionates; D014280:Triglycerides; D002784:Cholesterol; D015248:Gemfibrozil