[Clinical features of paclitaxel-induced peripheral neuropathy and role of Gosya-jinki-gan].
Paclitaxel (PTX) is frequently used for a chemotherapy of breast cancer and gynecologic cancer. Besides a bone-marrow depression and hypersensitive reaction, the peripheral neuropathy is one of the serious adverse events of PTX. The mechanism of peripheral neuropathy has not been clarified, and few agents have been reported to be effective for the treatment and the prevention of that. Recently, it has been reported that Gosya-jinki-gan is useful for the PTX induced peripheral neuropathy, so we carried a retrospective study(n=82)to evaluate the effectiveness of Gosya-jinkigan with the medical records. It is suggested that peripheral neuropathy developed more rapidly in sequential administration of PTX every week than in administration in 4 weeks cycles consisting of 3 weeks on and 1 week off(5.4w vs. 9.4w). We have also found that Gosya-jinki-gan was possibly effective for the treatment and the prevention of peripheral neuropathy. Additionally Gosya-jinki-gan might be more effective for peripheral neuropathy when it is administered from the beginning of chemotherapy including PTX.
Yamamoto
Tomoya
T
Dept. of Pharmacy, Osaka University Hospital, Japan.
Murai
Tasuku
T
Ueda
Mikiko
M
Katsuura
Masato
M
Oishi
Masako
M
Miwa
Yoshihiro
Y
Okamoto
Yoshiaki
Y
Uejima
Etsuko
E
Taguchi
Tetsuya
T
Noguchi
Shinzaburo
S
Kurokawa
Nobuo
N
D001943:Breast Neoplasms / Q000188:drug therapy; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy; D006801:Humans; D017239:Paclitaxel / Q000009:adverse effects* / Q000627:therapeutic use; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D010936:Plant Extracts / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D014815:Vitamins / Q000627:therapeutic use
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D014815:Vitamins; C119642:gosha-jinki-gan; D017239:Paclitaxel