title: Whole-body section fluorescence imaging--a novel method for tissue distribution studies of fluorescent substances.
abstract: The present study demonstrates the usefulness of whole body section fluorescence imaging, a novel technique used in optical imaging drug discovery. This method is in principle an analog of whole body autoradiography, except that fluorescence is measured instead of radioactivity. The method was shown to have a linear concentration-response relationship over a 1000-fold concentration range. Densitometric image analysis allowed semiquantitative studies of drug disposition and selective tumor retention of an optical imaging drug candidate.
authors.affiliation: Research and Development, GE Healthcare, Nycoveien 2, N-0401 Oslo, Norway. siver.a.moestue@ntnu.no
authors.forename: Siver
authors.initials: S
authors.lastname: Moestue
authors.forename: Paula
authors.initials: P
authors.lastname: Nunez
authors.forename: Andrew
authors.initials: A
authors.lastname: Healey
authors.forename: Roger
authors.initials: R
authors.lastname: Bjerke
authors.forename: Bård
authors.initials: B
authors.lastname: Indrevoll
authors.forename: Tore
authors.initials: T
authors.lastname: Skotland
authors.forename: Svein Olaf
authors.initials: SO
authors.lastname: Hustvedt
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000379:methods*; D003952:Diagnostic Imaging / Q000379:methods*; D005453:Fluorescence; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D014018:Tissue Distribution; D014915:Whole-Body Counting / Q000379:methods*