Systemic infection of avian influenza A virus H5N1 subtype in humans.
The viral dissemination in a patient with avian influenza A subtype H5N1 infection was retrospectively studied by the immunohistochemical localization of viral nucleoprotein antigen. The pathology was marked by diffuse alveolar damage, lymphoid depletion, and reactive hemophagocytic syndrome. Besides the lung and the upper respiratory tract, viral antigen was detected in the small and large intestinal epithelial cells, hematopoietic cells in the bone marrow, glial cells and neurons of the brain, and lymphocytes. The results confirmed that H5N1 virus disseminated to multiple organs beyond the respiratory system. However, specific pathological changes were noted in the respiratory system only, and productive viral replication confirmed by culture was noted only in the lung. More postmortem studies are needed to elucidate the pathogenesis of this highly fatal zoonotic disease.
Zhang
Zengfeng
Z
State Key Laboratory for Emerging Infectious Diseases, Department of Microbiology and Research Center of Infection and Immunology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.
Zhang
Jinxia
J
Huang
Kai
K
Li
Kang-Sheng
KS
Yuen
Kwok-Yung
KY
Guan
Yi
Y
Chen
Honglin
H
Ng
Wai Fu
WF
D000328:Adult; D000956:Antigens, Viral / Q000032:analysis; D001253:Astrocytes / Q000821:virology; D015153:Blotting, Western; D001853:Bone Marrow / Q000821:virology; D003106:Colon / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D053124:Influenza A Virus, H5N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000473:pathology* / Q000503:physiopathology / Q000821:virology*; D007421:Intestine, Small / Q000821:virology; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D009698:Nucleoproteins / Q000032:analysis
D000956:Antigens, Viral; D009698:Nucleoproteins