title: In vivo testing of nanoparticle-treated TTCP/DCPA-based ceramic surfaces.
abstract: This study reports the development of a non-dispersive calcium phosphate cement (nd-CPC) paste containing tetracalcium phosphate and anhydrous dicalcium phosphate that can be used as a filling material in dental and orthopedic applications. The nd-CPC bone cement is compared with two commercial materials, OsteoSet and Collagraft bone grafts. Gross examination of retrieved implants/bone composite samples indicated that none of the implants in this study evoked an inflammatory response. The OsteoSet (calcium sulfate) implant was resorbed too quickly to allow for osteo-remodeling, and it led to the formation of fibrous connective tissue in the fracture site, which remained even 24 weeks after implantation. Histological examination revealed that nd-CPC and Collagraft (hydroxyapatite/tricalcium phosphate/collagen) had greater remodeling and osteoconductive activity than OsteoSet at both 12 and 24 weeks after implantation. Greater remodeling activities were found with nd-CPC cement than with the other materials at 12 weeks after implantation, and the Fourier transform infrared absorption band of carbonate or cellulose derivatives grew from 6 weeks to 24 weeks after implantation in nd-CPC cement. These findings show that nd-CPC compares favorably to commercial bone remodeling materials, and the fact that it is in a paste formulation makes it an ideal material to fill regeneration defects.
authors.affiliation: School of Dentistry, Kaohsiung Medical University, 807 Kaohsiung, Taiwan, ROC.
authors.forename: Wen-Cheng
authors.initials: WC
authors.lastname: Chen
authors.forename: Chien-Ping
authors.initials: CP
authors.lastname: Ju
authors.forename: Yin-Chun
authors.initials: YC
authors.lastname: Tien
authors.forename: Jiin-Huey Chern
authors.initials: JH
authors.lastname: Lin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001843:Bone Cements / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry*; D005269:Femur / Q000166:cytology; D020007:Implants, Experimental; D008297:Male; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D010795:Phthalic Acids / Q000737:chemistry*; D019919:Prosthesis Implantation; D011817:Rabbits; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D013997:Time Factors
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; D010795:Phthalic Acids; C485830:tetracalcium phosphate; C007220:dimethyl 2,3,5,6-tetrachloroterephthalate