title: [Evaluation of compliance with bundle treatment in the management of severe infection].
abstract: OBJECTIVE
  To evaluate compliance with bundle treatment in the management of severe infection in a tertiary hospital, aiming at analyzing clinical data in order to popularize guidelines for management of severe sepsis and septic shock.
  
  
  METHODS
  A 14-month (from November 1, 2006 to December 31, 2007) prospective observational study of a group of 43 patients admitted to the respiratory intensive care unit in First Affiliated Hospital (tertiary hospital) of Guangzhou Medical College meeting the criteria for severe pneumonia and septic shock was carried out. Implementation of 6-hour and 24-hour bundle treatment for severe infection was divided into three phases consisting of education, trial, and application. A cohort of 43 patients with matched disease history admitted during January 1, 2004 to October 31, 2006 were enrolled as control group.
  
  
  RESULTS
  (1) In 6-hour bundle treatment for severe infection, 20.9% (9/43) had serum lactate measured, blood culture was obtained prior to antibiotic administration in 7.0% (3/43) of patients, 100% (43/43) had empirical antibiotics administration within 1 hour, an infusion of an initial minimum of 20 ml/kg of crystalloid or colloid equivalent (1.1 ml/kg of 20% albumin or 4.8 ml/kg of 6% hydroxyethyl starch) was given in 44.2% (19/43), with infused fluid (converted into 6% hydroxyethyl starch) reaching (503.95+/-176.19) ml within 6 hours, in 94.7% (18/19) of patients had received vasopressors , and inotropic dobutamine and/or transfusion of packed red blood cells were administered in 7.0% (3/43). (2) In 24-hour bundle treatment for severe infection group, 31.6% (6/19) had received low-dose steroids, 34.9% (15/43) had their blood glucose controlled<8.3 mmol/L, mechanical ventilation with inspiratory plateau pressures maintained<30 cm H(2)O (1 cm H(2)O=0.098 kPa, 6 ml/kg tidal volume) was instituted in 97.6% (40/41) of patients. (3) The percentage of compliance with 6-hour and 24-hour bundle treatment for severe infection were 0 and 21.4% respectively, total compliance was also 0. (4) As compared with control group, a 23.30% absolute mortality reduction was found in bundle group (18.6% vs. 41.9%, P=0.019).
  
  
  CONCLUSIONS
  Bundle treatment for severe infection is complied with partially in our hospital, suggesting that it is still quite arduous to popularize guidelines for management of severe sepsis and septic shock in our country.
authors.affiliation: Guangzhou Institute of Respiratory Disease, First Affiliated Hospital, Guangzhou Medical College, Guangzhou 510120, Guangdong, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Guo
authors.forename: Yi-min
authors.initials: YM
authors.lastname: Li
authors.forename: Ling-bo
authors.initials: LB
authors.lastname: Nong
authors.forename: Yuan-da
authors.initials: YD
authors.lastname: Xu
authors.forename: Guo-qing
authors.initials: GQ
authors.lastname: He
authors.forename: Wei-qun
authors.initials: WQ
authors.lastname: He
authors.forename: Si-bei
authors.initials: SB
authors.lastname: Chen
authors.forename: Xiao-qing
authors.initials: XQ
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Mei
authors.initials: M
authors.lastname: Jiang
authors.forename: Yong-hao
authors.initials: YH
authors.lastname: Xu
authors.forename: Zheng-lun
authors.initials: ZL
authors.lastname: Xiao
mesh_terms: D005240:Feasibility Studies; D019983:Guideline Adherence; D006801:Humans; D007362:Intensive Care Units; D011446:Prospective Studies; D018805:Sepsis / Q000628:therapy*; D012772:Shock, Septic / Q000628:therapy*