Depression is an early disease manifestation in lupus-prone MRL/lpr mice.
Many lupus patients develop neuropsychiatric manifestations, including cognitive dysfunction, depression, and anxiety. However, it is not clear if neuropsychiatric lupus is a primary disease manifestation, or is secondary to non-CNS disease. We found that MRL/lpr lupus-prone mice exhibited significant depression-like behavior already at 8 weeks of age, despite normal visual working memory, locomotor coordination and social preference. Moreover, depression was significantly correlated with titers of autoantibodies against DNA, NMDA receptors and cardiolipin. Our results indicate that lupus mice develop depression and CNS dysfunction very early in the course of disease, in the absence of substantial pathology involving other target organs.
Gao
Hua-Xin
HX
The Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, NY, USA.
Campbell
Sean R
SR
Cui
Min-Hui
MH
Zong
Pu
P
Hee-Hwang
Jong
J
Gulinello
Maria
M
Putterman
Chaim
C
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001323:Autoantibodies / Q000097:blood; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D002308:Cardiolipins / Q000276:immunology; D002794:Choline / Q000378:metabolism; D002843:Chromatin / Q000276:immunology; D003401:Creatine / Q000378:metabolism; D004247:DNA / Q000276:immunology; D003863:Depression / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D008817:Mice, Mutant Strains; D011507:Proteinuria / Q000378:metabolism; D011597:Psychomotor Performance / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology; D021641:Recognition, Psychology / Q000502:physiology; D012919:Social Behavior; D013550:Swimming
D001323:Autoantibodies; D002308:Cardiolipins; D002843:Chromatin; D016194:Receptors, N-Methyl-D-Aspartate; D001224:Aspartic Acid; D004247:DNA; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline