Haplotype analysis of the CYP8A1 gene associated with myocardial infarction.
OBJECTIVE
The aim of this study was to assess the association between the human CYP8A1 gene and myocardial infarction (MI) in Chinese people.


METHODS
210 MI patients and 206 age-matched controls were genotyped and constructed haplotypes for 3 SNPs [3982C>T (rs5602), C1117A (rs5629), C251T (rs454-98106)] of the human CYP8A1 gene.


RESULTS
The CC genotype of rs5629 was more frequently in MI patients than in control subjects (P = .030). The frequency of the A-C-T haplotype was significantly higher in MI patients than in control subjects (P =.001). The frequency of the C-T-T haplotype was significantly lower in MI patients than in control subjects (P= .011).


CONCLUSIONS
The present results indicate that MI is associated with the CC genotype of rs5629 in the human CYP8A1 gene. The A-C-T haplotype appears to be a useful genetic marker and the C-T-T haplotype might be a protective factor of MI in Chinese people.
Xiang Xie
Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Ma
Yi-Tong
YT
Fu
Zhen-Yan
ZY
Yang
Yi-Ning
YN
Xiang Ma
Chen
Bang-Dang
BD
Wang
Ying-Hong
YH
Fen Liu
D000368:Aged; D016022:Case-Control Studies; D002681:China; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology* / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D003577:Cytochrome P-450 Enzyme System; C472456:PTGIS protein, human