title: Coadministration of coenzyme Q prevents rosiglitazone-induced adipogenesis in ob/ob mice.
abstract: OBJECTIVE
  The aim of this study is to determine the effect of coenzyme Q (Q) on ob/ob mice treated or not with thiazolidinedione (TZD).
  
  
  METHODS
  Ob/ob mice were treated with Q, Rosiglitazone or a combination of both molecules for 13 days; physical and metabolic parameters as well as oral glucose tolerance test were assessed. mRNA expression of genes of energy dissipation and storage were measured by real-time PCR.
  
  
  RESULTS
  Q treatment improved some metabolic parameters in ob/ob mice. Surprisingly, cotreatment with Rosiglitazone and Q improved metabolic parameters and prevented TZD increase in body weight and adiposity, mainly by increasing lipid oxidation in adipose tissue, reducing lipid synthesis and balancing adipokine gene expression.
  
  
  CONCLUSIONS
  Our finding suggests that Rosiglitazone and coenzyme Q bitherapy could prevent the body weight gain associated with adipogenesis and could improve the clinical use of these compounds.
authors.affiliation: UMR 5241 UPS-CNRS, IFR109, CHU Rangueil, Toulouse Cedex, France.
authors.forename: M C
authors.initials: MC
authors.lastname: Carmona
authors.forename: P
authors.initials: P
authors.lastname: Lefebvre
authors.forename: B
authors.initials: B
authors.lastname: Lefebvre
authors.forename: A
authors.initials: A
authors.lastname: Galinier
authors.forename: A
authors.initials: A
authors.lastname: Benani
authors.forename: Y
authors.initials: Y
authors.lastname: Jeanson
authors.forename: K
authors.initials: K
authors.lastname: Louche
authors.forename: S
authors.initials: S
authors.lastname: Flajollet
authors.forename: A
authors.initials: A
authors.lastname: Ktorza
authors.forename: C
authors.initials: C
authors.lastname: Dacquet
authors.forename: L
authors.initials: L
authors.lastname: Pénicaud
authors.forename: L
authors.initials: L
authors.lastname: Casteilla
mesh_terms: D050156:Adipogenesis / Q000187:drug effects* / Q000235:genetics; D000818:Animals; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects / Q000235:genetics; D005951:Glucose Tolerance Test; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000008:administration & dosage / Q000494:pharmacology*; D014451:Ubiquinone / Q000008:administration & dosage / Q000494:pharmacology*; D015430:Weight Gain / Q000187:drug effects* / Q000235:genetics
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D000077154:Rosiglitazone; D014451:Ubiquinone