title: Vascular endothelial growth factor in aqueous humor of patients with perforative eye injuries.
abstract: Considering that VEGF is the key factor for angiogenesis stimulation, we wanted to establish if VEGF level is increased in aqueous humor of patients with open globe eye injury. The study included 20 patients with open globe injury. During the surgery, aqueous humor samples were taken out and VEGF levels were measured by ELISA. VEGF levels were significantly higher in the aqueous humor of patients with open globe eye injury and uveitis, in patients with wound bigger than 2 mm and in patients where from injury to surgery passed more than 4 hours. VEGF levels were also higher, but not significantly, in patients with intrabulbar foreign body. Considering that VEGF levels were significantly higher in patients with open globe eye injury with uveitis, wound larger than 2 mm and in patients where from injury to surgery passed more than 4 hours, anti VEGF therapy might have application in these conditions.
authors.affiliation: Department of Ophthalmology, University Hospital Rijeka, Rijeka, Croatia. maja.merlak@gmail.com
authors.forename: Maja
authors.initials: M
authors.lastname: Merlak
authors.forename: Damir
authors.initials: D
authors.lastname: Kovacević
authors.forename: Tihomir
authors.initials: T
authors.lastname: Balog
authors.forename: Tanja
authors.initials: T
authors.lastname: Marotti
authors.forename: Renata
authors.initials: R
authors.lastname: Grzetić Lenac
authors.forename: Ivana
authors.initials: I
authors.lastname: Romac
authors.forename: Iva
authors.initials: I
authors.lastname: Dekaris
mesh_terms: D001082:Aqueous Humor / Q000378:metabolism*; D005129:Eye Foreign Bodies / Q000209:etiology / Q000378:metabolism; D015807:Eye Injuries, Penetrating / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A