title: Functional evolution of cyclin-dependent kinases.
abstract: Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases with a well established role in the regulation of the eukaryotic cell cycle. Recent studies with animal cells have implicated CDK activity in additional diverse cellular processes, including transcription, translation and mRNA processing. In plants, such CDK functions are poorly characterized and the implication of CDK phosphorylation in regulation of gene expression is just begining to emerge. In this review we compare CDK functions in plants, animals and yeasts with particular focus on the biological processes that different members participate in and regulate. Finally, based on the available information of CDK function, we propose an alternative evolutionary scenario for the CDK gene family.
authors.affiliation: Department of Cell & Developmental Biology, John Innes Centre, Norwich, NR4 7UH, UK. john.doonan@bbsrc.ac.uk
authors.forename: John H
authors.initials: JH
authors.lastname: Doonan
authors.forename: Georgios
authors.initials: G
authors.lastname: Kitsios
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000235:genetics* / Q000502:physiology*; D019143:Evolution, Molecular; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D010802:Phylogeny; D010944:Plants; D014176:Protein Biosynthesis; D012326:RNA Splicing; D014158:Transcription, Genetic; D015003:Yeasts
chemical_list: D018844:Cyclin-Dependent Kinases