title: [(NHC)Au(I)]-catalyzed acid-free alkyne hydration at part-per-million catalyst loadings.
abstract: A highly efficient [(NHC)Au(I)]-based (NHC = N-heterocyclic carbene) catalytic system for the hydration of an array of alkynes that operates under acid-free conditions and at very low catalyst loadings (typically 50-100 ppm and as low as 10 ppm) was developed. Terminal and internal alkynes possessing any combination of alkyl and aryl substituents (alkyl/H, aryl/H, alkyl/alkyl, alkyl/aryl, and aryl/aryl) were found suitable substrates in the present catalytic system.
authors.affiliation: Institute of Chemical Research of Catalonia (ICIQ), 43007 Tarragona, Spain.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Marion
authors.forename: Rubén S
authors.initials: RS
authors.lastname: Ramón
authors.forename: Steven P
authors.initials: SP
authors.lastname: Nolan