X-ray structure of native scorpion toxin BmBKTx1 by racemic protein crystallography using direct methods.
Racemic protein crystallography, enabled by total chemical synthesis, has allowed us to determine the X-ray structure of native scorpion toxin BmBKTx1; direct methods were used for phase determination. This is the first example of a protein racemate that crystallized in space group I41/a.
Mandal
Kalyaneswar
K
Department of Chemistry, The University of Chicago, Chicago, Illinois 60637, USA.
Pentelute
Brad L
BL
Tereshko
Valentina
V
Kossiakoff
Anthony A
AA
Kent
Stephen B H
SB
D000818:Animals; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D011489:Protein Denaturation; D017434:Protein Structure, Tertiary; D012604:Scorpion Venoms / Q000737:chemistry*; D012605:Scorpions / Q000737:chemistry*
C490373:BKTx1 protein, Buthus martensi; D012604:Scorpion Venoms