Polycations. 18. The synthesis of polycationic lipid materials based on the diamine 1,4-diazabicyclo[2.2.2]octane.
Herein is reported the preparation of several series of polyammonium salts that serve as cationic lipids or precursors thereof, and are structurally based on the parent diamine 1,4-diazabicyclo[2.2.2]octane (dabco). Through selective alkylation of dabco a variety of di- and tetracationic lipid species and precursors thereof have been prepared. The resultant materials are of significant interest for a variety of purposes, including serving as antimicrobial agents and antihydrophobic species, the details of which are provided in separate reports.
Engel
Robert
R
Department of Chemistry and Biochemistry, Queens College of CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367, USA. robert.engel@qc.cuny.edu
Rizzo
Jaimelee Iolani
JI
Rivera
Christina
C
Ramirez
Mariah
M
Huang
Mia Lace
ML
Montenegro
Diego
D
Copodiferro
Craig
C
Behaj
Valbona
V
Thomas
Marie
M
Klaritch-vrana
Barbara
B
Engel
Jeanne Fabian
JF
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry; D003959:Diamines / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry; D010879:Piperazines / Q000737:chemistry*; D011073:Polyamines / Q000138:chemical synthesis* / Q000737:chemistry; D000071228:Polyelectrolytes
D000890:Anti-Infective Agents; D003959:Diamines; D008055:Lipids; D010879:Piperazines; D011073:Polyamines; D000071228:Polyelectrolytes; C007306:triethylenediamine