title: Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells.
abstract: The antigenotoxic effect of apigenin was studied against the genotoxic damage induced by mitomycin C on mouse bone marrow cells using sister chromatid exchanges (SCEs) and chromosomal aberrations (CAs) as parameters. Apigenin was studied at three different doses i.e. 10, 20 and 40 mg/kg b.w. and was found to be non-genotoxic at all the above three doses. Mitomycin C at 2 mg/kg b.w. was given along with the 10, 20 and 40 mg/kg bw of apigenin. A significant decrease in SCEs and CAs was observed, suggesting a protective role of apigenin against the genotoxicity of mitomycin C on mice bone marrow cells.
authors.affiliation: Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, U.P. 202 002, India. yasir_hasansiddique@rediffmail.com
authors.forename: Yasir Hasan
authors.initials: YH
authors.lastname: Siddique
authors.forename: Mohammad
authors.initials: M
authors.lastname: Afzal
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D047310:Apigenin / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D016685:Mitomycin / Q000633:toxicity*; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange
chemical_list: D016587:Antimutagenic Agents; D009153:Mutagens; D016685:Mitomycin; D047310:Apigenin