[The current concept of immunological disorders in the case of basal-cell carcinoma].
Imbalance in the interaction of mechanisms of innate and adaptive immunity rather than selective defect of each of the links is a determinant of the development of basal-cell carcinoma of this or that form of immunopathology or that of transformation of one to another form. The lecture gives notions on immunological phenotypes and the parameters of innate and adaptive immunity and on the association of two links of immunity. The major tumor-associated immunological phenotypes are pathogenetically and clinically different, but have signs of two-link immunodeficiency in each case. Tumor-associated secondary immunodeficiency is characterized by defects encompassing both the innate and adaptive links of immunity. Predominant are autoimmune disorders involving mainly the adaptive link of immunological responsiveness in case of tumor-associated autoimmune syndrome concurrent with immunodeficiency.
Kostalevskaia
A V
AV
Petrunin
D D
DD
Romadanova
N B
NB
Snarskaia
E S
ES
Pal'tsev
M A
MA
Suchkov
S V
SV
D000917:Antibody Formation; D015551:Autoimmunity; D002280:Basal Cell Carcinoma / Q000150:complications / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D010641:Phenotype; D012878:Skin Neoplasms / Q000150:complications / Q000276:immunology*