title: The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study.
abstract: The aim of this study was to examine the relationships between the daily life events and the availabilities of serotonin transporters (SERT) and dopamine transporters (DAT) in healthy volunteers. Thirty-seven volunteers, 19 males and 18 females, were recruited. The SERT availability was approximated using SPECT and [123I] ADAM while the DAT availability was approximated using SPECT and [99mTc] TRODAT-1. All participants completed the Recent Life Change Questionnaire. The results showed that SERT and DAT may be sensitive to the presence of stressful events.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Kao Ching
authors.initials: KC
authors.lastname: Chen
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
authors.forename: Wei Jen
authors.initials: WJ
authors.lastname: Yao
authors.forename: Yeng Kuang
authors.initials: YK
authors.lastname: Yang
authors.forename: Nan Tsing
authors.initials: NT
authors.lastname: Chiu
authors.forename: Ru Band
authors.initials: RB
authors.lastname: Lu
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D001921:Brain / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013223:Statistics as Topic; D013315:Stress, Psychological / Q000000981:diagnostic imaging / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D055815:Young Adult
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins