[Hormones, cytokines and macroglobulines in blood of women with autoimmune thyroid diseases].
OBJECTIVE
To study proportions of hormones, cytokines and macroglobulins in autoimmune thyroid diseases.


METHODS
Participants of the study were 28 females aged 43 +/- 5 years with diffuse toxic goiter (DTG), 31 females aged 41 +/- 6 years with autoimmune thyroiditis (AIT) and 26 controls (n = 26) free of thyroid pathology aged 40 +/- 4 years. DTG and AIT diagnoses were confirmed by ultrasound and laboratory examinations.


RESULTS
Both autoimmune diseases were accompanied by a significant rise of serum IL-6 and fall of TNF-alpha levels vs those in the controls. In AIT interferon-gamma was higher than in DTG while in DTG alpha-2-macroglobulin rose higher but TNF-alpha reduced more than in AIT.


CONCLUSIONS
It is suggested that an elevated level of interferon-gamma in AIT contributes to blockade of endocytosis of peptid hormones and cytokines transported by macroglobulins. Overproduction of IL-6 in DTG may be caused by deficiency of its antagonist--TNF-gamma leading to an increase in macroglobulin concentration, its gene inductor is the above interleukin.
Zorin
N A
NA
Maklakova
T P
TP
Appel'gans
T V
TV
Arkhipova
S V
SV
Bichan
I V
IV
D000328:Adult; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D013967:Thyroiditis, Autoimmune / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D000511:alpha-Macroglobulins / Q000378:metabolism*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D000511:alpha-Macroglobulins; D013973:Thyrotropin-Releasing Hormone; D007371:Interferon-gamma