Low-dose involved-field radiotherapy as alternative treatment of nodular lymphocyte predominance Hodgkin's lymphoma.
OBJECTIVE
Nodular lymphocyte predominance Hodgkin's lymphoma is a very rare disease, characterized by an indolent clinical course, with sometimes very late relapses occurring in a minority of all patients. Considerable discussion is ongoing on the treatment of primary and relapsed disease.


METHODS
A group of 9 patients were irradiated to a dose of 4 Gy on involved areas only.


RESULTS
After a median follow-up of 37 months (range, 6-66), the overall response rate was 89%. Six patients had complete remission (67%), two had partial remission (22%), and one had stable disease (11%). Of 8 patients, 5 developed local relapse 9-57 months after radiotherapy. No toxicity was noted.


CONCLUSIONS
In nodular lymphocyte predominance Hodgkin's lymphoma, low-dose radiotherapy provided excellent response rates and lasting remissions without significant toxicity.
Haas
Rick L M
RL
Department of Radiotherapy, The Netherlands Cancer Institute Amsterdam, Amsterdam, The Netherlands. r.haas@nki.nl
Girinsky
Theo
T
Aleman
Berthe M P
BM
Henry-Amar
Michel
M
de Boer
Jan-Paul
JP
de Jong
Daphne
D
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012008:Recurrence; D012074:Remission Induction; D055815:Young Adult