title: Rehmannia glutinosa ameliorates the progressive renal failure induced by 5/6 nephrectomy.
abstract: OBJECTIVE
  Rehmannia glutinosa, the steamed root of the Scrophulariaceae family, has been widely used in Asian countries for the treatment of renal diseases. In this study, we evaluated the renoprotective effect of aqueous extract of Rehmannia glutinosa in progressive renal failure.
  
  
  METHODS
  The effects of Rehmannia glutinosa on renal function, 24-h proteinuria, and the expression of angiotensin II, angiotensin II type 1 (AT(1)) receptor, TGF-beta1, and type IV collagen in renal cortex were analyzed in progressive renal failure rats induced by 5/6 nephrectomy.
  
  
  RESULTS
  Rehmannia glutinosa reduced the serum creatinine level, 24-h urinary protein excretion, and glomerulosclerosis, and it also inhibited the expression of angiotensin II, AT(1) receptor, TGF-beta1 and type IV collagen in the renal cortex.
  
  
  CONCLUSIONS
  These results suggest that the renoprotective effect of Rehmannia glutinosa might be mediated by suppressing the expression of angiotensin II and AT(1) receptor and by regulating TGF-beta1 and type IV collagen expression.
authors.affiliation: Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-Ku, Seoul 130-702, Republic of Korea.
authors.forename: Byung-Cheol
authors.initials: BC
authors.lastname: Lee
authors.forename: Jong-Bae
authors.initials: JB
authors.lastname: Choi
authors.forename: Hyun-Ju
authors.initials: HJ
authors.lastname: Cho
authors.forename: Young-Seung
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000418:Albumins / Q000378:metabolism; D000803:Angiotensin I / Q000097:blood / Q000378:metabolism; D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001806:Blood Urea Nitrogen; D024141:Collagen Type IV / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008055:Lipids / Q000097:blood; D008297:Male; D009392:Nephrectomy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D032267:Rehmannia; D051437:Renal Insufficiency / Q000188:drug therapy* / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000097:blood
chemical_list: D000418:Albumins; D024141:Collagen Type IV; D008055:Lipids; D010936:Plant Extracts; D020011:Protective Agents; D012333:RNA, Messenger; D053773:Transforming Growth Factor beta1; D000804:Angiotensin II; D000803:Angiotensin I; D003404:Creatinine