title: [Treatment of acute ischemic stroke with intravenous thrombolysis: extension of the time window should not delay initiation of treatment].
abstract: In the European Cooperative Acute Stroke Study 3 (ECASS3), the efficacy of intravenous thrombolysis between 3 and 4.5 hours following onset of ischaemic stroke was investigated. Compared to the placebo group, patients treated with intravenous alteplase had a better functional outcome after 3 months (odds ratio 1.34, 95% confidence interval 1.02-1.76). The risk of symptomatic intracerebral haemorrhage was higher in the alteplase group (2.4% versus 0.3%). The time window for intravenous alteplase can be safely extended to 4.5 hours, but efforts should be made to start treatment as soon as possible, since the effectiveness ofalteplase decreases over time.
authors.affiliation: Universitair Medisch Centrum Groningen, afd. Neurologie, Postbus 30.001, 9700 RB Groningen. m.uyttenboogaart@neuro.umcg.nl
authors.forename: M
authors.initials: M
authors.lastname: Uyttenboogaart
authors.forename: G J
authors.initials: GJ
authors.lastname: Luijckx
authors.forename: L J
authors.initials: LJ
authors.lastname: Kappelle
authors.forename: R J
authors.initials: RJ
authors.lastname: van Oostenbrugge
authors.forename: D W J
authors.initials: DW
authors.lastname: Dippel
authors.forename: J
authors.initials: J
authors.lastname: Stam
mesh_terms: D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D005343:Fibrinolytic Agents