title: Discovery of novel small molecule cell type-specific enhancers of NF-kappaB nuclear translocation.
abstract: An IKKbeta inhibitor reported to block NF-kappaB transcriptional activities in Jurkat T cells, was found to enhance NF-kappaB translocation in HUVEC cells. These studies suggested a noncanonical NF-kappaB signaling pathway independent of IKKbeta in HUVEC cells.
authors.affiliation: Department of Medicine, Columbia University, 650 W 168th Street, BB 1029, New York, NY 10032, USA.
authors.forename: Gangli
authors.initials: G
authors.lastname: Gong
authors.forename: Yuli
authors.initials: Y
authors.lastname: Xie
authors.forename: Yidong
authors.initials: Y
authors.lastname: Liu
authors.forename: Alison
authors.initials: A
authors.lastname: Rinderspacher
authors.forename: Shi-Xian
authors.initials: SX
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: Zhu
authors.forename: Yufei
authors.initials: Y
authors.lastname: Tang
authors.forename: Michael
authors.initials: M
authors.lastname: Wyler
authors.forename: Nathalie
authors.initials: N
authors.lastname: Aulner
authors.forename: Udo
authors.initials: U
authors.lastname: Toebben
authors.forename: Deborah H
authors.initials: DH
authors.lastname: Smith
authors.forename: Lars
authors.initials: L
authors.lastname: Branden
authors.forename: Caty
authors.initials: C
authors.lastname: Chung
authors.forename: Stephan
authors.initials: S
authors.lastname: Schürer
authors.forename: Dusica
authors.initials: D
authors.lastname: Vidović
authors.forename: Donald W
authors.initials: DW
authors.lastname: Landry
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006801:Humans; D019169:Jurkat Cells; D007976:Leupeptins / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D016328:NF-kappa B / Q000187:drug effects / Q000378:metabolism*; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013450:Sulfones / Q000737:chemistry / Q000494:pharmacology; D013454:Sulfoxides / Q000737:chemistry / Q000494:pharmacology; D013777:Tetrazoles / Q000737:chemistry / Q000494:pharmacology
chemical_list: C434003:3-(4-methylphenylsulfonyl)-2-propenenitrile; D007976:Leupeptins; D016328:NF-kappa B; D009570:Nitriles; D011799:Quinazolines; C461648:Ro 106-9920; D013450:Sulfones; D013454:Sulfoxides; D013777:Tetrazoles; C072553:benzyloxycarbonylleucyl-leucyl-leucine aldehyde