title: [Short-term results of audiological change of nasopharyngeal carcinoma patient after radiotherapy and chemotherapy].
abstract: OBJECTIVE
  To investigate short-stage results of audiological change of nasopharyngeal carcinoma patients after radiotherapy and chemotherapy treatment.
  
  
  METHODS
  According to treatment modus of nasopharyngeal carcinoma, 64 cases (128 ears) patients were divided to simple radiotherapy group (45 cases, 90 ears) and radiotherapy with chemotherapy group (combination treatment group, 19 cases, 38 ears). Meanwhile, 25 cases (50 ears) people took as control group, who had no obviously ear and nose disease. About two or three months after radiotherapy and chemotherapy treatment completion, three groups were detected by otoscopy, pure tone test, tympanogram and eustachian tube function, respectively. Then, hearing variation of all patients after radiotherapy and chemotherapy treatment were investigated and compared each other. At the same time, the character and level of audiological change were also analyzed.
  
  
  RESULTS
  Eardrum character of nasopharyngeal carcinoma patients appeared change after radiotherapy. Simple radiotherapy and combination treatment groups were found having hearing impairment and eustachian tube functional disturbance. Moreover, most patients of simple radiotherapy group showed conductive deaf (24%, 22/90), and combination treatment group exhibited mingle (24%, 9/38) or sensorineural deafness (29%, 11/38).
  
  
  CONCLUSIONS
  Recent hearing of nasopharyngeal carcinoma patients were damaged by radiotherapy and chemotherapy treatment, radiotherapy treatment induced middle ear or eustachian tube function disturbance, chemotherapy treatment had cochleotoxicity, compared with other treatment, combination treatment was more aggravated hearing impairment.
authors.affiliation: Department of Otorhinolaryngology, Second Affiliated Hospital of Nanhua University, Hunan Hengyang 421001, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Xiao
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Luo
authors.forename: Da-zhi
authors.initials: DZ
authors.lastname: Shi
authors.forename: Yuan-jian
authors.initials: YJ
authors.lastname: Huang
authors.forename: Yu-fang
authors.initials: YF
authors.lastname: Tan
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001301:Audiometry, Pure-Tone; D016022:Case-Control Studies; D005064:Eustachian Tube / Q000503:physiopathology; D005260:Female; D034381:Hearing Loss / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000503:physiopathology* / Q000628:therapy; D010033:Otitis Media / Q000209:etiology; D018787:Radiation Oncology