title: Use of Tris-hydroxymethyl aminomethane in severe lactic acidosis due to highly active antiretroviral therapy: a case report.
abstract: BACKGROUND
  Lactic acidosis is a rare, yet life-threatening adverse drug effect of highly active antiretroviral therapy (HAART), specifically stavudine and lamivudine. These nucleoside analogue reverse transcriptase inhibitors (NRTIs) are commonly used to treat patients infected with the human immunodeficiency virus (HIV).
  
  
  METHODS
  We report the use of Tris-hydroxymethyl aminomethane (THAM) to treat severe lactic acidosis due to HAART in a 50-year-old African-American woman. NRTIs can cause hyperlactinaemia by interfering with mitochondrial oxidative phosphorylation function, which normally removes H(+) generated by the hydrolysis of adenosine triphosphate. This side-effect is associated with a high mortality in patients infected with HIV. One explanation for this high mortality is that lactic acidosis is typically refractory to treatment with commonly used buffering agents.
  
  
  CONCLUSIONS
  THAM generates serum bicarbonate, and reduces the level of carbon dioxide in arterial blood. Both of these qualities appear to make THAM an ideal agent for treating lactic acidosis caused by HAART.
authors.affiliation: Department of Pharmacy Montefiore Medical Center, Bronx, NY, USA.
authors.forename: K
authors.initials: K
authors.lastname: Marfo
authors.forename: M
authors.initials: M
authors.lastname: Garala
authors.forename: V
authors.initials: V
authors.lastname: Kvetan
authors.forename: J
authors.initials: J
authors.lastname: Gasperino
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000188:drug therapy*; D019380:Anti-HIV Agents / Q000009:adverse effects*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D002021:Buffers; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D014325:Tromethamine / Q000627:therapeutic use*
chemical_list: D019380:Anti-HIV Agents; D002021:Buffers; D014325:Tromethamine