title: Transcranial magnetic stimulation of the primary motor cortex modulates response interference in a flanker task.
abstract: In a typical flanker task, responses to a central target ("S" or "N") are modulated by whether the flankers are compatible ("SSSSS") or incompatible ("NNSNN"), with increased reaction times and decreased accuracy on incompatible trials. The role of the motor system in response interference under these conditions remains unclear, however. Here we show that transcranial magnetic stimulation (TMS) of the left primary motor cortex modulates the amount of flanker interference depending on the hand used for the response. Left motor TMS delivered at 200ms after the onset of the array increased interference from incompatible flankers ("SSNSS") when the target response was associated with the contralateral motor response (i.e. for "N" responses with the right hand), relative to when responses were to targets using the (left) hand ipsilateral to the site of TMS. Interestingly, under identical conditions, the degree of flanker interference was reduced when the TMS pulse was applied later in time. The analyses of the TMS-induced motor evoked potentials pointed to motor activity varying in the same conditions. We discuss the implications for understanding response interference and the role of the primary motor cortex in response selection.
authors.affiliation: Division of Neuroscience and Mental Health, Imperial College London, London W6 8RP, UK. d.soto@imperial.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Soto
authors.forename: Pedro R
authors.initials: PR
authors.lastname: Montoro
authors.forename: Glyn W
authors.initials: GW
authors.lastname: Humphreys
mesh_terms: D000293:Adolescent; D000328:Adult; D001288:Attention / Q000502:physiology* / Q000528:radiation effects; D003071:Cognition / Q000502:physiology* / Q000528:radiation effects; D019054:Evoked Potentials, Motor / Q000502:physiology / Q000528:radiation effects; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006225:Hand / Q000294:innervation / Q000502:physiology; D006801:Humans; D008297:Male; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology* / Q000528:radiation effects; D009068:Movement / Q000502:physiology / Q000528:radiation effects; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology* / Q000528:radiation effects; D011827:Radiation; D011930:Reaction Time / Q000502:physiology* / Q000528:radiation effects; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D055815:Young Adult