title: Myocardial (123)I-MIBG scintigraphy for differentiation of Lewy bodies disease from FTD.
abstract: Clinical distinction between Lewy bodies disease (LBD) and frontotemporal dementia (FTD) is sometimes difficult. Nigrostriatal dopaminergic degeneration occurs in both LBD and FTD, limiting helpfulness of DAT imaging to differentiate these forms of dementia. Several studies have emphasized the usefulness of myocardial scintigraphy with (123)Metaiodobenzylguanidine ((123)I-MIGB) in assessing the sympathetic nerve terminals in LBD demonstrating that cardiac (123)I-MIGB uptake is decreased in patients with this disease. We investigated the role of cardiac (123)I-MIBG scintigraphy in differentiating patients with LBD from those with FTD. Clinical diagnosis of LBD and FTD was determined according to established consensus criteria. Nine patients with LBD (1 possible and 8 probable), 6 patients with FTD, and 16 control subjects were involved in the study. The heart to mediastinum ratio (H/M) of (123)I-MIBG uptake was markedly reduced in all patients with LBD (H/M early: 1.25±0.12; delayed: 1.14±0.13) whereas it was normal in patients with FTD (H/M early: 1.86±0.20; delayed: 1.80±0.23) and in controls (H/M early: 1.91±0.17; delayed: 1.99±0.19), suggesting that cardiac (123)I-MIBG scintigraphy can help distinguish patients with LBD from those with FTD.
authors.affiliation: Institute of Neurology, University Magna Graecia, Catanzaro, Italy.
authors.forename: Fabiana
authors.initials: F
authors.lastname: Novellino
authors.forename: Antonio
authors.initials: A
authors.lastname: Bagnato
authors.forename: Maria
authors.initials: M
authors.lastname: Salsone
authors.forename: Giuseppe Lucio
authors.initials: GL
authors.lastname: Cascini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nicoletti
authors.forename: Gennarina
authors.initials: G
authors.lastname: Arabia
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Pugliese
authors.forename: Maurizio
authors.initials: M
authors.lastname: Morelli
authors.forename: Sandra
authors.initials: S
authors.lastname: Paglionico
authors.forename: Stefania
authors.initials: S
authors.lastname: Cipullo
authors.forename: Ida
authors.initials: I
authors.lastname: Manna
authors.forename: Elvira Valeria
authors.initials: EV
authors.lastname: De Marco
authors.forename: Francesca
authors.initials: F
authors.lastname: Condino
authors.forename: Carmelina
authors.initials: C
authors.lastname: Chiriaco
authors.forename: Letterio
authors.initials: L
authors.lastname: Morgante
authors.forename: Mario
authors.initials: M
authors.lastname: Zappia
authors.forename: Aldo
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging*; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D020961:Lewy Body Disease / Q000000981:diagnostic imaging*; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging; D009483:Neuropsychological Tests; D019275:Radiopharmaceuticals; D018709:Statistics, Nonparametric; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine