The relationships between daily life events and the availabilities of serotonin transporters and dopamine transporters in healthy volunteers--a dual-isotope SPECT study.
The aim of this study was to examine the relationships between the daily life events and the availabilities of serotonin transporters (SERT) and dopamine transporters (DAT) in healthy volunteers. Thirty-seven volunteers, 19 males and 18 females, were recruited. The SERT availability was approximated using SPECT and [123I] ADAM while the DAT availability was approximated using SPECT and [99mTc] TRODAT-1. All participants completed the Recent Life Change Questionnaire. The results showed that SERT and DAT may be sensitive to the presence of stressful events.
Yeh
Tzung Lieh
TL
Department of Psychiatry, National Cheng Kung University Hospital, Tainan, Taiwan.
Lee
I Hui
IH
Chen
Kao Ching
KC
Chen
Po See
PS
Yao
Wei Jen
WJ
Yang
Yeng Kuang
YK
Chiu
Nan Tsing
NT
Lu
Ru Band
RB
D000203:Activities of Daily Living; D000328:Adult; D001921:Brain / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013223:Statistics as Topic; D013315:Stress, Psychological / Q000000981:diagnostic imaging / Q000378:metabolism*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D055815:Young Adult
D050483:Dopamine Plasma Membrane Transport Proteins; D050486:Serotonin Plasma Membrane Transport Proteins