title: Randomized controlled trial of a brief intervention for problematic prescription drug use in non-treatment-seeking patients.
abstract: OBJECTIVE
  Dependence on or problematic use of prescription drugs (PD) is estimated to be between 1 and 2% in the general population. In contrast, the proportion of substance-specific treatment in PD use disorders at 0.5% is comparatively low. With an estimated prevalence of 4.7%, PD-specific disorders are widespread in general hospitals compared to the general population. Brief intervention delivered in general hospitals might be useful to promote discontinuation or reduction of problematic prescription drug use.
  
  
  METHODS
  A randomized, controlled clinical trial.
  
  
  METHODS
  Internal, surgical and gynaecological wards of a general and a university hospital.
  
  
  METHODS
  One hundred and twenty-six patients fulfilling criteria for either regular use of PD (more than 60 days within the last 3 months) or dependence on or abuse of PD, respectively, were allocated randomly to two conditions.
  
  
  METHODS
  Subjects received two counselling sessions based on Motivational Interviewing plus an individualized written feedback (intervention group, IG) or a booklet on health behaviour (control group, CG).
  
  
  METHODS
  The outcome was measured as reduction (>25%) and discontinuation of PD intake in terms of defined daily dosages (DDD).
  
  
  RESULTS
  After 3 months, more participants in the IG reduced their DDD compared to the participants in the CG (51.8% versus 30%; chi(2) = 6.17; P = 0.017). In the IG 17.9%, in the CG 8.6% discontinued use of PD (chi(2) = 2.42; P = 0.17). Conclusions Brief intervention based on Motivational Interviewing is effective in reducing PD intake in non-treatment-seeking patients.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany. anne.zahradnik@psychiatrie.uk-sh.de
authors.forename: Anne
authors.initials: A
authors.lastname: Zahradnik
authors.forename: Christiane
authors.initials: C
authors.lastname: Otto
authors.forename: Brit
authors.initials: B
authors.lastname: Crackau
authors.forename: Ira
authors.initials: I
authors.lastname: Löhrmann
authors.forename: Gallus
authors.initials: G
authors.lastname: Bischof
authors.forename: Ulrich
authors.initials: U
authors.lastname: John
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Rumpf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003376:Counseling / Q000379:methods; D005260:Female; D006801:Humans; D008875:Middle Aged; D009042:Motivation; D010342:Patient Acceptance of Health Care; D018579:Patient Selection; D055553:Prescription Drugs; D011320:Primary Health Care / Q000379:methods*; D011614:Psychotherapy, Brief / Q000379:methods*; D019966:Substance-Related Disorders / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D055553:Prescription Drugs