[Targeting therapy for inflammatory diseases by anti-TNFalpha biologics].
TNFalpha (tumor necrosis factor-alpha) plays a critical role in the pathogenesis of inflammatory diseases including rheumatoid arthritis and Crohn's disease. Infliximab is a monoclonal antibody that recognizes human TNFalpha. Clinical trials have been persuasive that infliximab is effective and far superior to the conventional drug therapy in various inflammatory diseases. Combination of infliximab plus methotrexate is effective in patients with active rheumatoid arthritis who have not responded adequately to traditional disease-modifying anti-rheumatic drugs, and has produced significant improvement in clinical, radiographic, and functional outcomes. Infliximab is also an important treatment option in patients with active Crohn's disease who have not responded to conventional therapy and in those with this disease who have fistulae. Moreover, infliximab treatment has resulted in effective suppression of ankylosing spondylitis, psoriasis and ocular inflammation in patients with refractory uveoretinitis due to Behçet's disease. Thus, biologics targeting TNFalpha have revolutionized the therapy of inflammatory diseases. Here, the current status of clinical application of anti-TNFalpha biologics is reviewed by describing the clinical outcome of infliximab and future prospects of biologics are discussed.
Sugita
Takahisa
T
Pharmacology Laboratory, Mitsubishi Tanabe Pharma Corporation, 1000 kamoshida-cho, Aoba-ku, Yokohama, Japan. sugita.takahisa@mp.mt-pharma.co.jp
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000209:etiology; D001528:Behcet Syndrome / Q000150:complications; D002986:Clinical Trials as Topic; D003424:Crohn Disease / Q000188:drug therapy; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000209:etiology; D000069285:Infliximab; D012173:Retinitis / Q000188:drug therapy / Q000209:etiology; D013167:Spondylitis, Ankylosing / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000502:physiology; D014605:Uveitis / Q000188:drug therapy / Q000209:etiology
D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab