title: Optimizing safety of selective internal radiation therapy (SIRT) of hepatic tumors with 90Y resin microspheres: a systematic approach to preparation and radiometric procedures.
abstract: Arterial administration of 90Y microspheres is used for salvage therapy in patients with primary or metastasized tumors within the liver. The clinical use of high-yield beta emitters presents unique calibration, dosage measurement, and exposure monitoring tasks. This report illustrates the following issues: determination of container and volume-specific correction factors in a standard dose calibrator for various receipt and dispensing vial geometries using a U.S. National Institute of Standards and Technology-traceable 90Y standard solution; documentation of delivery and localization of the radionuclide; statistically-verified ion chamber measurements of residual (non infused) radioactivity; and measurement of occupational radiation exposures.
authors.affiliation: Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA. aschleipman@partners.org
authors.forename: A Robert
authors.initials: AR
authors.lastname: Schleipman
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Gallagher
authors.forename: Victor H
authors.initials: VH
authors.lastname: Gerbaudo
mesh_terms: D001918:Brachytherapy / Q000379:methods* / Q000592:standards; D006801:Humans; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008863:Microspheres; D011785:Quality Assurance, Health Care; D011874:Radiometry / Q000379:methods*; D012449:Safety; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D015021:Yttrium Radioisotopes