title: Spectrophotometric determination of quinolone antibiotics by an association complex formation with aluminum(III) and erythrosin.
abstract: A simple and sensitive spectrophotometric method for the determination of quinolone antibiotics was established based on an association complex formation with aluminum(III) and erythrosin. In the determination of ofloxacin as a quinolone antibiotic, Beer's law is obeyed in the range of 0.1 - 3.2 microg ml(-1), with an effective molar absorptivity at 555 nm and the relative standard deviation being 1.2 x 10(5) L mol(-1) cm(-1) and 0.9% (n = 6). This method was successfully applied to the assay of quinolone antibiotics in pharmaceutical preparations.
authors.affiliation: Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka 569-1094, Japan.
authors.forename: Takako
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nakao
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Nakahara
authors.forename: Yuka
authors.initials: Y
authors.lastname: Nishioka
authors.forename: Chiho
authors.initials: C
authors.lastname: Ikeda
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Fujita
mesh_terms: D000535:Aluminum / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000032:analysis*; D004923:Erythrosine / Q000737:chemistry; D015242:Ofloxacin / Q000032:analysis; D011804:Quinolines / Q000032:analysis*; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D011804:Quinolines; D015242:Ofloxacin; D000535:Aluminum; D004923:Erythrosine