title: Use of sealants in pancreatic surgery: critical appraisal of the literature.
abstract: OBJECTIVE
  Fibrin sealants containing both fibrin and thrombin have been used to control bleeding, reinforce suture lines and enhance tissue healing. However, the literature provides contradictory results.
  
  
  METHODS
  A systematic literature search was performed to determine the use of fibrin sealants in pancreatic surgery. These articles were then critically appraised according to their methodologies, outcomes and conclusions.
  
  
  RESULTS
  Twenty-four studies were found, including 6 controlled randomized trials. Of these, 16 studies were analyzed. Many methodological flaws and lack of consistency in definitions were found, making comparisons between studies difficult if not impossible.
  
  
  CONCLUSIONS
  Because of the heterogeneity and lack of high-level evidence, the current literature does not allow us any conclusion: neither is there proof that fibrin sealants are of any real utility in pancreatic surgery, nor that they do not work. Further large-scale controlled trials are necessary before concluding that they do or do not provide any advantages in pancreatic surgery.
authors.affiliation: Department of Digestive Surgery, Centre Hospitalier Intercommunal, Poissy, France. abefinger@aol.com
authors.forename: Abe
authors.initials: A
authors.lastname: Fingerhut
authors.forename: Nicolas
authors.initials: N
authors.lastname: Veyrie
authors.forename: Toufik
authors.initials: T
authors.lastname: Ata
authors.forename: Nicholas
authors.initials: N
authors.lastname: Alexakis
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Leandros
mesh_terms: D000714:Anastomosis, Surgical; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D007422:Intestines / Q000601:surgery*; D010179:Pancreas / Q000601:surgery*; D010180:Pancreatectomy; D010183:Pancreatic Ducts / Q000601:surgery
chemical_list: D015718:Fibrin Tissue Adhesive