title: Smoking cessation treatment in a real-life setting: the Greek experience.
abstract: OBJECTIVE
  The aim of this study was to estimate the clinical efficacy of counseling combined with currently used pharmacotherapy for smoking cessation (bupropion SR and nicotine replacement therapy, NRT) in actual clinical practice, and to identify predictors of successful abstinence at the end of therapy, as well as predictors of sustained abstinence in one year.
  
  
  METHODS
  895 smokers, self-motivated to quit, received bupropion SR for 7 or 19 weeks and/or nicotine replacement therapy (NRT) (nicotine patch) for 9 weeks in combination with individual behavioural therapy. An intensive program including repetitive visits and telephone contacts during treatment and one year's follow-up period was available for supporting and motivating smokers to prevent relapse.
  
  
  RESULTS
  Post-treatment abstinence rates were 71.6% and 53.2% in bupropion SR groups for 7 and 19 weeks of treatment, respectively, (p < 0.001), 63.4% in bupropion SR plus nicotine patch group and 45% (p < 0.001) in nicotine patch group. One year's follow-up abstinence rates were 43.1%, 29.6%, 30.4% and 18.4% (p < 0.05), respectively. Predictors of successful abstinence at the end of therapy included (a) bupropion SR, (b) lower DSM IV symptom score, and (c) lower nicotine addiction, while predictors for sustained abstinence in one year included: (a) bupropion SR, (b) lower nicotine addiction, and (c) smoker's motivation.
  
  
  CONCLUSIONS
  Smoking cessation interventions implementing intensive multi-component programs and constant smokers' motivation in health care settings of actual practice seem promising for increasing short and long-term abstinence rates.
authors.affiliation: Smoking Cessation Clinic, Pulmonary and Critical Care Department, Evgenidion Hospital, 20 Papadiamantopoulou Str., 11528, Athens, Greece. rovinanikoletta@hotmail.com
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Rovina
authors.forename: Ioanna
authors.initials: I
authors.lastname: Nikoloutsou
authors.forename: Efi
authors.initials: E
authors.lastname: Dima
authors.forename: Makrina
authors.initials: M
authors.lastname: Michailidou
authors.forename: Charalampos
authors.initials: C
authors.lastname: Roussos
authors.forename: Christina
authors.initials: C
authors.lastname: Gratziou
mesh_terms: D000328:Adult; D016642:Bupropion / Q000627:therapeutic use; D003376:Counseling; D018765:Dopamine Uptake Inhibitors / Q000627:therapeutic use; D005260:Female; D006115:Greece; D006801:Humans; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000008:administration & dosage; D016540:Smoking Cessation / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D018765:Dopamine Uptake Inhibitors; D016642:Bupropion; D009538:Nicotine