title: [Study of maternal nutrition and genetic on the foetal adiposity programming (The PREOBE study)].
abstract: BACKGROUND
  Maternal genetics and feeding before and during pregnancy, different maternal metabolic pathologies, as well as nutrient intakes of newborns in their first months of life may be involved in the obesity aetiology and its long-term consequences. The possible role of these and others factors, the mechanisms and the effects on the metabolism, and the development of this disease need further research.
  
  
  OBJECTIVE
  To acquire more knowledge about foetal adipose tissue development and the influence of genetic, dietetic and environmental factors on the risk to suffer from obesity.
  
  
  METHODS
  Four study groups have been established with 30 pregnant women in each one: 1) control group; 2) mothers with glucose intolerance/gestational diabetes; 3) women with low weight gain during pregnancy, and 4) women with overweight/obesity at the beginning of the pregnancy. The magnitudes to be studied are: 1) dietary intake; 2) life-style habits; 3) physical activity; 4) anthropometry and body composition; 5) haematological study; 6) biochemical study (lipid and metabolic biomarkers); 7) immune function profile related to nutritional status; 8) psychological profile; 9) genetic biomarkers, and 10) microbiological markers; all of them in relation to the development of the foetal adipose tissue in the first stages of life and the risk of suffering from obesity in the future.
  
  
  CONCLUSIONS
  This project, coordinated by the Department of Paediatrics of the School of Medicine in the University of Granada, and with the collaboration of well-known and expert research groups, tries to contribute to the knowledge about the obesity aetiology in infancy and its subsequent development in later periods of life.
authors.affiliation: Departamento de Pediatría, Facultad de Medicina, Universidad de Granada, Granada, España. ccampoy@ugr.es
authors.forename: C
authors.initials: C
authors.lastname: Campoy
authors.forename: E
authors.initials: E
authors.lastname: Martín-Bautista
authors.forename: L
authors.initials: L
authors.lastname: García-Valdés
authors.forename: J
authors.initials: J
authors.lastname: Florido
authors.forename: A
authors.initials: A
authors.lastname: Agil
authors.forename: J A
authors.initials: JA
authors.lastname: Lorente
authors.forename: A
authors.initials: A
authors.lastname: Marcos
authors.forename: M C
authors.initials: MC
authors.lastname: López-Sabater
authors.forename: T
authors.initials: T
authors.lastname: Miranda-León
authors.forename: Y
authors.initials: Y
authors.lastname: Sanz
authors.forename: J A
authors.initials: JA
authors.lastname: Molina-Font
mesh_terms: D000273:Adipose Tissue / Q000196:embryology*; D000293:Adolescent; D000328:Adult; D005260:Female; D047109:Fetal Development / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D055815:Young Adult