[Physiology of blood coagulation and fibrinolysis: biochemistry].
The principles of initiator and amplifications reactions of blood coagulation and fibrinolysis will be presented and discussed in relation to various regulatory pathways of haemostasis. In particular, cell surface-dependent activation and inhibition reactions are characteristics of multicomponent enzyme complexes that also allow the endogenous control of the haemostasis system. The understanding of these relationships in complications of haemostasis has lead to different strategies for the therapeutic intervention with pro- and anticoagulant substances.
Preissner
K T
KT
Institut für Biochemie, Fachbereich Medizin, Justus-Liebig-Universität, Friedrichstr. 24, 35392 Giessen. klaus.t.preissner@biochemie.med.uni-giessen.de
D000925:Anticoagulants / Q000627:therapeutic use; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism; D003029:Coagulants / Q000627:therapeutic use; D005341:Fibrinolysin / Q000502:physiology; D005342:Fibrinolysis / Q000502:physiology*; D006487:Hemostasis / Q000502:physiology; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism; D015843:Serpins / Q000378:metabolism
D000925:Anticoagulants; D001779:Blood Coagulation Factors; D003029:Coagulants; D009097:Multienzyme Complexes; D015843:Serpins; D006493:Heparin; D005341:Fibrinolysin