Using detachment-promoting agents for the prevention of chronic peritoneal dialysis-associated infections.
Biofilms are known to be responsible for chronic peritoneal dialysis (PD)-related infections. Such infections are still frequent among patients in PD. The aim of this study was to develop a new approach in the prevention of chronic PD-related infection by regular injection of specific formulations containing detachment-promoting agents. A biofilm reactor system reproducing PD-like operating conditions was developed. A first set of experiments allowed the assessment of the anti-biofilm efficacy of various formulations. Then, experiments were performed for a longer duration and selected formulations were tested and compared with taurolidine. Biofilm removal was quantified by calculating the percentage of coverage reduction compared with an untreated control. A regular weekly treatment led to a 97% reduction of the surface coverage although a daily treatment with taurolidine still left 48% of the biomass on the surface. Such treatment is recommended to reduce the frequencies of chronic PD-related infections.
Branger
Bernard
B
CHU de Nîmes, Service de Néphrologie, Nimes, France.
Marion
Karine
K
Bergeron
Emmanuelle
E
Perret
Cécile
C
Zabadani
Bachir
B
Reboul
Pascal
P
Freney
Jean
J
D000890:Anti-Infective Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D055499:Catheter-Related Infections / Q000517:prevention & control*; D002408:Catheters, Indwelling / Q000009:adverse effects; D006801:Humans; D017053:Infection Control / Q000379:methods*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010538:Peritonitis / Q000209:etiology / Q000517:prevention & control; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology; D013829:Thiadiazines / Q000494:pharmacology; D013997:Time Factors
D000890:Anti-Infective Agents; D013829:Thiadiazines; D013654:Taurine; C012566:taurolidine