title: Biomarkers of pathophysiology in hypertrophic cardiomyopathy: implications for clinical management and prognosis.
abstract: The study of biomarkers and their signalling pathways has allowed the development of new therapeutic strategies in a range of disorders. The aim of the present systematic review is to provide an overview of different biomarkers in patients with hypertrophic cardiomyopathy that could give some insight into the pathophysiologic mechanism(s) underlying the typical clinical and histological manifestations of the disease. Several pathophysiological models are presented and discussed, including studies that have investigated these biomarkers for diagnostic and prognostic reasons, in relation to disease progression and/or mortality.
authors.affiliation: Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
authors.forename: Francisco
authors.initials: F
authors.lastname: Cambronero
authors.forename: Francisco
authors.initials: F
authors.lastname: Marín
authors.forename: Vanessa
authors.initials: V
authors.lastname: Roldán
authors.forename: Diana
authors.initials: D
authors.lastname: Hernández-Romero
authors.forename: Mariano
authors.initials: M
authors.lastname: Valdés
authors.forename: Gregory Y H
authors.initials: GY
authors.lastname: Lip
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000401:mortality; D004730:Endothelium, Vascular / Q000503:physiopathology; D006801:Humans; D008954:Models, Biological; D011379:Prognosis
chemical_list: D015415:Biomarkers