A case of maternal herpes simplex virus encephalitis during late pregnancy.
BACKGROUND
A pregnant 25-year-old woman at 32 weeks' gestation was admitted to an emergency unit after her husband had found her drowsy and with her tongue bitten. The day before admission, the patient had developed a fever of 39 degrees C, was suffering from headaches, was nauseated and had vomited. On admission, she had anterograde and retrograde amnesia, but no somatic neurological deficits were detected.


METHODS
Routine laboratory testing, lumbar puncture, cerebrospinal fluid analysis, routine bacteriology, brain MRI, and polymerase chain reaction testing for neurotropic viruses including herpes simplex virus types 1 and 2.


METHODS
Maternal herpes simplex virus type 1 encephalitis.


RESULTS
Antiviral and anticonvulsive therapy, supportive treatment, and cesarean section.
Sellner
Johann
J
Department of Neurology, Klinikum rechts der Isar at the Technical University of Munich, Munich, Germany.
Buonomano
Roberto
R
Nedeltchev
Krassen
K
Findling
Oliver
O
Schroth
Gerhard
G
Surbek
Daniel V
DV
Leib
Stephen L
SL
D000212:Acyclovir / Q000627:therapeutic use; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology / Q000821:virology; D020803:Encephalitis, Herpes Simplex / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D018259:Herpesvirus 1, Human; D006801:Humans; D000077213:Lamotrigine; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology*; D012640:Seizures / Q000517:prevention & control / Q000821:virology; D014227:Triazines / Q000627:therapeutic use
D000927:Anticonvulsants; D000998:Antiviral Agents; D014227:Triazines; D000077213:Lamotrigine; D000212:Acyclovir