title: Single-institution study evaluating the utility of surveillance bronchoscopy after lung transplantation.
abstract: BACKGROUND
  Many lung transplant physicians advocate surveillance bronchoscopy with transbronchial lung biopsy and bronchoalveolar lavage (TBB/BAL) to monitor lung recipients despite limited evidence this strategy improves outcomes. This report compares rates of infection (INF), acute rejection (AR), bronchiolitis obliterans syndrome (BOS) and survival in lung allograft recipients managed with surveillance TBB/BAL (SB) versus those with clinically indicated TBB/BAL (CIB).
  
  
  METHODS
  We reviewed 47 consecutive recipients transplanted between March 2002 and August 2005. Of these recipients, 24 consented to a multi-center trial requiring SB and 23 were managed by our usual practice of CIB. Rates of freedom from INF, AR, BOS and survival were compared. BOS and AR were diagnosed according to published guidelines from the International Society for Heart and Lung Transplantation.
  
  
  RESULTS
  A total of 240 TBB/BALs were performed. CIB and SB groups underwent 84 (3.7 +/- 3.4/patient) and 156 (6.5 +/- 2.0/patient) TBB/BALs, respectively. In the SB group, 54 (2.2 +/- 1.6/patient) TBB/BALs were true surveillance procedures, whereas 102 (4.2 +/- 2.3/patient) were clinically indicated. No AR episode requiring treatment was detected by true surveillance. Freedom from respiratory INF, AR, BOS and survival in the SB and CIB groups showed no significant differences. Five patients in the CIB group remained stable without requiring TBB/BAL. In the SB group, 4 previously asymptomatic patients developed pneumonia within 2 weeks of surveillance TBB/BAL.
  
  
  CONCLUSIONS
  With no obvious advantage identified, surveillance bronchoscopy may pose a risk to stable lung transplant recipients. A multi-center, controlled trial is required to validate the utility and safety of surveillance bronchoscopy in lung transplantation.
authors.affiliation: Department of Lung Transplantation, University of Texas Medical Branch, Galveston, Texas, USA. vgvalent@utmb.edu
authors.forename: Vincent G
authors.initials: VG
authors.lastname: Valentine
authors.forename: Meera R
authors.initials: MR
authors.lastname: Gupta
authors.forename: David
authors.initials: D
authors.lastname: Weill
authors.forename: Gisele A
authors.initials: GA
authors.lastname: Lombard
authors.forename: Stephanie G
authors.initials: SG
authors.lastname: LaPlace
authors.forename: Leonardo
authors.initials: L
authors.lastname: Seoane
authors.forename: David E
authors.initials: DE
authors.lastname: Taylor
authors.forename: Gundeep S
authors.initials: GS
authors.lastname: Dhillon
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001989:Bronchiolitis Obliterans / Q000453:epidemiology; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy / Q000379:methods*; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006801:Humans; D007239:Infections / Q000453:epidemiology; D007902:Length of Stay; D008171:Lung Diseases / Q000145:classification / Q000601:surgery; D016040:Lung Transplantation / Q000401:mortality / Q000473:pathology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D015337:Multicenter Studies as Topic; D011183:Postoperative Complications / Q000145:classification / Q000453:epidemiology; D011184:Postoperative Period; D012189:Retrospective Studies; D016019:Survival Analysis; D014184:Transplantation, Homologous; D055815:Young Adult