[Progress in genetic modification of vascular prostheses and its significance in molecular reconstruction].
OBJECTIVE
To summarize the current progress in the genetic modification of vascular prostheses and to look forward to the future of genetic modification in vascular prostheses.


METHODS
PubMed online search with the key words of "vascular prostheses, gene" was undertaken to identify articles about the genetic modification of vascular prostheses. Then these articles were reviewed and summarized.


RESULTS
To improve long-term patency of vascular prostheses, various genes were transfected into seeded cells. The anti thrombosis activity of local vessels increased.


CONCLUSIONS
Progresses in tissue engineering and molecular biology make possible endothelialization and genetic modification of vascular prostheses. However, because most relevant researches are still basic experiments, further study is needed before clinical application.
Hu
Lingyu
L
Department of Vascular Surgery, First Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong 510080, PR China.
Hu
Zuojun
Z
Wang
Shenming
S
D001807:Blood Vessel Prosthesis; D030781:Organisms, Genetically Modified; D011474:Prosthesis Design; D023822:Tissue Engineering