A facile synthesis of pyridazinone derivatives under ultrasonic irradiation.
A new, efficient and general method for preparation of N-substituted-pyridazinones using ultrasound irradiation is reported. Under ultrasound the reaction time decreases substantially, the yields are high and the reaction conditions are mild. It was noticed that substituents at the 3-(6)-position of pyridazone heterocycle have a substantial influence on the reactivity, while the effect of the substituents at the 1-(2)-position seems to be of minor importance. A comparative study of the reactions performed under ultrasound conditions versus at room temperature has been done.
Mantu
Dorina
D
Al. I. Cuza University of Iasi, Organic and Biochemistry Department, Bd. Carol 11, 700506 Iasi, Romania.
Moldoveanu
Costel
C
Nicolescu
Alina
A
Deleanu
Calin
C
Mangalagiu
Ionel I
II
D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry*; D013696:Temperature; D014465:Ultrasonics
D011724:Pyridazines