Ultrastructural reorganization of rat adrenal cortex after whole body hyperthermia.
Intracellular reorganization of mouse adrenocorticocytes after single whole body hyperthermia is determined by the two main events: development of the general adaptation syndrome and inhibition of the regeneratory plastic reactions in cells resultant from endotoxication and redistribution of plastic resources between organs and tissues. Stress-induced changes manifest in significant exhaustion of lipid droplets in the adrenocorticocytes of all adrenocortical zones, particularly in the zona fasciculata. Intracellular changes in adrenocorticocytes reflecting the development of regeneratory plastic insufficiency manifest in annular transformation of the nucleoli, segregation of the nucleolonema into granular and fibrillar components, intensification of autophagocytosis, and destructive changes in mitochondria and Golgi complex elements. The most pronounced changes were observed in adrenocorticocytes of the zona reticularis.
Koldysheva
E V
EV
Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk. pathol@soramn.ru
Lushnikova
E L
EL
D000222:Adaptation, Physiological; D000302:Adrenal Cortex / Q000503:physiopathology / Q000648:ultrastructure*; D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D005334:Fever / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D046529:Microscopy, Electron, Transmission; D051381:Rats; D012038:Regeneration