title: Developing a tissue resource to characterize the genome of pancreatic cancer.
abstract: With recent advances in DNA sequencing technology, medicine is entering an era in which a personalized genomic approach to diagnosis and treatment of disease is feasible. However, discovering the role of altered DNA sequences in various disease states will be a challenging task. The genomic approach offers great promise for diseases, such as pancreatic cancer, in which the effect of current diagnostic and treatment modalities is disappointing. To facilitate the characterization of the genome of pancreatic cancer, high-quality and well-annotated tissue repositories are needed. This article summarizes the basic principles that guide the creation of such a repository, including sample processing and preservation techniques, sample size and composition, and collection of clinical data elements.
authors.affiliation: Michael E. DeBakey Department of Surgery, Baylor College of Medicine, 1709 Dryden, Suite 1500, Houston, TX 77030, USA.
authors.forename: Georgios
authors.initials: G
authors.lastname: Voidonikolas
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Gingras
authors.forename: Sally
authors.initials: S
authors.lastname: Hodges
authors.forename: Amy L
authors.initials: AL
authors.lastname: McGuire
authors.forename: Changyi
authors.initials: C
authors.lastname: Chen
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gibbs
authors.forename: F Charles
authors.initials: FC
authors.lastname: Brunicardi
authors.forename: William E
authors.initials: WE
authors.lastname: Fisher
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000235:genetics*; D019295:Computational Biology; D003219:Confidentiality; D030541:Databases, Genetic; D023281:Genomics; D006801:Humans; D007258:Informed Consent; D019188:Organ Preservation Solutions; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000235:genetics*; D015995:Prevalence; D011786:Quality Control; D013048:Specimen Handling; D014015:Tissue Banks / Q000331:legislation & jurisprudence / Q000458:organization & administration* / Q000592:standards; D014481:United States / Q000453:epidemiology
chemical_list: D019188:Organ Preservation Solutions