title: Prediction, clinical characteristics and prognosis of intracerebral hemorrhage in hepatocellular carcinoma patients with intracerebral metastasis.
abstract: The clinical characteristics of intracerebral hemorrhage (ICH) in hepatocellular carcinoma (HCC) patients with intracerebral metastasis (IcM) have not been reported on extensively. We compared the clinical characteristics between patients with ICH (w-ICH, 18 patients) and without ICH (wo-ICH, 24 patients) in HCC patients with IcM. Using multivariate logistic regression, only habitual alcohol consumption is a significant predictor of ICH in HCC patients with IcM (adjusted odds ratio [OR]=4.7, 95% CI=1.26-17.71, p=0.022). Patients with ICH also had lower Glasgow Coma Scale scores at the time of admission (p=0.032) and lower incidence of infratentorial metastasis (p=0.014). Using correlation analysis, only blood platelet count on admission was positively correlated with survival duration after the diagnosis of IcM in the wo-ICH group (p=0.000) but not in the w-ICH group.
authors.affiliation: Department of Neurology, Chang Gung Memorial Hospital-Kaohsiung Medical Center, Chang Gung University College of Medicine, 123 Ta Pei Road, Niao Sung Hsiang, Kaohsiung Hsien, Taiwan.
authors.forename: Mei-Jen
authors.initials: MJ
authors.lastname: Hsieh
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Lu
authors.forename: Nai-Wen
authors.initials: NW
authors.lastname: Tsai
authors.forename: Chun-Chung
authors.initials: CC
authors.lastname: Lui
authors.forename: Yao-Chung
authors.initials: YC
authors.lastname: Chuang
authors.forename: Chi-Ren
authors.initials: CR
authors.lastname: Huang
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Chen
authors.forename: Chiung-Chih
authors.initials: CC
authors.lastname: Chang
authors.forename: Hsueh-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Wen-Neng
authors.initials: WN
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000150:complications / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000150:complications* / Q000401:mortality / Q000473:pathology*; D002543:Cerebral Hemorrhage / Q000175:diagnosis* / Q000209:etiology*; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D016019:Survival Analysis