title: Efficacy of a genetically engineered Candida albicans tet-NRG1 strain as an experimental live attenuated vaccine against hematogenously disseminated candidiasis.
abstract: We report on the efficacy of the genetically engineered Candida albicans tet-NRG1 strain as an experimental live, attenuated vaccine against disseminated candidiasis in both immunocompetent and immunodeficient mice mostly dependent on T-cell immunity. This experimental vaccination model may represent an important tool to unravel the mechanisms of protective immunity during candidiasis.
authors.affiliation: Department of Biology and South Texas Center for Emerging Infectious Diseases, the University of Texas at San Antonio, San Antonio, Texas 78249, USA.
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Saville
authors.forename: Anna L
authors.initials: AL
authors.lastname: Lazzell
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Chaturvedi
authors.forename: Carlos
authors.initials: C
authors.lastname: Monteagudo
authors.forename: Jose L
authors.initials: JL
authors.lastname: Lopez-Ribot
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000235:genetics / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology / Q000517:prevention & control*; D005657:Fungal Vaccines / Q000235:genetics / Q000276:immunology*; D051379:Mice; D020890:Neuregulin-1 / Q000235:genetics / Q000276:immunology*; D016019:Survival Analysis; D013601:T-Lymphocytes / Q000276:immunology; D014613:Vaccines, Attenuated / Q000235:genetics / Q000276:immunology; D014614:Vaccines, Synthetic / Q000235:genetics / Q000276:immunology
chemical_list: D005657:Fungal Vaccines; D020890:Neuregulin-1; D014613:Vaccines, Attenuated; D014614:Vaccines, Synthetic