title: Synthesis of (-)-berkelic acid.
abstract: An extremophilic challenge: Stereospecific condensation of a fully functionalized ketal aldehyde and a 2,6-dihydroxybenzoic acid is the key step in the synthesis of (-)-berkelic acid confirming Fürstner's reassignment of the stereochemistry at C18 and C19, establishing the absolute stereochemistry, and tentatively assigning the stereochemistry at C22.
authors.affiliation: Department of Chemistry, MS 015, Brandeis University, Waltham, MA 02454-9110, USA.
authors.forename: Xiaoxing
authors.initials: X
authors.lastname: Wu
authors.forename: Jingye
authors.initials: J
authors.lastname: Zhou
authors.forename: Barry B
authors.initials: BB
authors.lastname: Snider
mesh_terms: D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D062385:Hydroxybenzoates / Q000138:chemical synthesis*; D013141:Spiro Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D062385:Hydroxybenzoates; D013141:Spiro Compounds; C520589:berkelic acid; C412605:gamma-resorcylic acid