title: Abnormal white matter signal on MR imaging is related to abnormal tissue microstructure.
abstract: OBJECTIVE
  White matter signal-intensity abnormalities (WMSA) on MR imaging are related to adverse neurodevelopmental outcome in extremely preterm infants. Diffusion tensor imaging (DTI) may detect alterations in cerebral white matter microstructure and thus may help confirm the pathologic basis of WMSA. This study aimed to relate regional DTI measures with severity of WMSA in very preterm infants.
  
  
  METHODS
  One hundred eleven preterm infants (birth weight, <1250 g and/or gestational age, <30 weeks) were scanned at term-equivalent age (1.5T). WMSA were classified as normal, focal, or extensive. Apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial (lambda1), and radial ([lambda2 + lambda3]/2) diffusivity were calculated in 12 regions of interest placed in the bilateral posterior limbs of the internal capsule, frontal (superior and inferior), sensorimotor, and occipital (superior and inferior) white matter regions. Data were compared by using 1-way analysis of variance, with a Bonferroni correction for multiple comparisons.
  
  
  RESULTS
  Thirty-nine infants had normal, 59 infants had focal, and 13 infants had extensive WMSA. Compared with infants with normal or focal WMSA, infants with extensive WMSA had significantly lower FA in the internal capsule (P < .001), right inferior frontal regions (P < .05), and right superior occipital regions (P = .01); and higher radial diffusivity in the right internal capsule (P = .005), bilateral sensorimotor (P < .05), and right superior occipital regions (P < .05). Compared with infants with normal WMSA, infants with extensive WMSA had significantly higher ADC in bilateral sensorimotor regions (P < .01) and right superior occipital regions (P = .01), and lower axial diffusivity in the bilateral sensorimotor regions (P < .05).
  
  
  CONCLUSIONS
  There are significant region-specific changes in ADC, FA, radial diffusivity, and axial diffusivity in preterm infants with extensive WMSA. Altered radial diffusivity was most prominent. This implies that disrupted premyelinating oligodendroglia is the major correlate with extensive WMSA rather than axonal pathology.
authors.affiliation: Victorian Infant Brain Studies, Murdoch Children's Research Institute, Parkville, Australia. jeanie.cheong@thewomens.org.au
authors.forename: J L Y
authors.initials: JL
authors.lastname: Cheong
authors.forename: D K
authors.initials: DK
authors.lastname: Thompson
authors.forename: H X
authors.initials: HX
authors.lastname: Wang
authors.forename: R W
authors.initials: RW
authors.lastname: Hunt
authors.forename: P J
authors.initials: PJ
authors.lastname: Anderson
authors.forename: T E
authors.initials: TE
authors.lastname: Inder
authors.forename: L W
authors.initials: LW
authors.lastname: Doyle
mesh_terms: D001921:Brain / Q000254:growth & development / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D020772:Internal Capsule / Q000473:pathology; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D009778:Occipital Lobe / Q000473:pathology; D009836:Oligodendroglia / Q000473:pathology; D012720:Severity of Illness Index