title: Rifamycin S and its geometric isomer produced by a newly found actinomycete, Micromonospora rifamycinica.
abstract: Strain AM105 was separated from mangrove sediment in the South China Sea in this research. The morphological and genomic data showed that the strain merits description as a novel species, proposed as Micromonospora rifamycinica. From the acetate ethyl extract of its fermentation broth, two antibiotics against Gram-positive bacteria (including MRSA), rifamycin S and its geometric isomer were isolated. Their structures were elucidated on the basis of spectroscopic analyzes. (1)H and (13)C NMR data of the isomer of rifamycin S were first described in this paper.
authors.affiliation: Key Laboratory of Tropical Crop Biotechnology of Agriculture Ministry, Institute of Tropical Biosciences and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, People's Republic of China. huanghq21@yahoo.com.cn
authors.forename: Huiqin
authors.initials: H
authors.lastname: Huang
authors.forename: Xiaopeng
authors.initials: X
authors.lastname: Wu
authors.forename: Sheng
authors.initials: S
authors.lastname: Yi
authors.forename: Zhiwang
authors.initials: Z
authors.lastname: Zhou
authors.forename: Jun
authors.initials: J
authors.lastname: Zhu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Fang
authors.forename: Jianmin
authors.initials: J
authors.lastname: Yue
authors.forename: Shixiang
authors.initials: S
authors.lastname: Bao
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D002681:China; D019015:Geologic Sediments / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008847:Micromonospora / Q000145:classification* / Q000166:cytology / Q000302:isolation & purification / Q000378:metabolism*; D015394:Molecular Structure; D012294:Rifamycins / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D012294:Rifamycins; C032779:rifamycin S