[Pharmacoepidemiology of antiepileptic drugs in children: comparative analysis of drug effectiveness and safety].
Pharmacoepidemiological analysis of the effectiveness and safety (tolerance) of antiepileptic drugs belonging to various classes has been carried out using data for a group of patients registered at municipal children epilepsy services, including 548 children in 2005 and 718 in 2007, aged between 2 months and 18 years. Remission lasting for at least 1 year or longer than 3 years was used as primary effectiveness criterion and the total number of adverse effects as the safety (tolerance) criterion. No advantages of new anticonvulsants over the older antiepileptic drugs in terms of efficacy and safety have been found.
Gamirova
R G
RG
Ziganshina
L E
LE
D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008499:Medical Records; D017891:Pharmacoepidemiology / Q000379:methods / Q000706:statistics & numerical data; D016896:Treatment Outcome
D000927:Anticonvulsants