title: DAP10- and DAP12-associated receptors in innate immunity.
abstract: The DAP10 and DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells. Some receptors are able to associate with either DAP10 or DAP12, which contribute unique intracellular signaling functions. Studies of humans and mice deficient in these signaling subunits have provided surprising insights into the physiological functions of DAP10 and DAP12, demonstrating that they can either activate or inhibit immune responses. DAP10- and DAP12-associated receptors have been shown to recognize both host-encoded ligands and ligands encoded by microbial pathogens, indicating that they play an important role in innate immune responses.
authors.affiliation: Department of Microbiology and Immunology, Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143-0414, USA. lewis.lanier@ucsf.edu
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Lanier
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D001324:Autoantigens / Q000276:immunology / Q000378:metabolism; D002241:Carbohydrates / Q000276:immunology; D017124:Conserved Sequence / Q000276:immunology; D019143:Evolution, Molecular; D025461:Feedback, Physiological / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology; D008562:Membrane Glycoproteins / Q000276:immunology / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D055629:Natural Cytotoxicity Triggering Receptor 2 / Q000276:immunology / Q000378:metabolism; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D039961:Semaphorins / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology; D000073871:Triggering Receptor Expressed on Myeloid Cells-1
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001324:Autoantigens; D002241:Carbohydrates; C120528:HCST protein, human; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C112837:NCR2 protein, human; D055629:Natural Cytotoxicity Triggering Receptor 2; D011971:Receptors, Immunologic; D039961:Semaphorins; C408842:TREM1 protein, human; C110546:TYROBP protein, human; D000073871:Triggering Receptor Expressed on Myeloid Cells-1