title: The effect of cetylpyridinium chloride-containing mouth rinses as adjuncts to toothbrushing on plaque and parameters of gingival inflammation: a systematic review.
abstract: OBJECTIVE
  To review the literature concerning cetylpyridinium chloride (CPC) containing mouth rinses as effective adjuncts to toothbrushing in the prevention of plaque accumulation and gingival inflammation.
  
  
  METHODS
  Medline and the Cochrane Central Register of Controlled Trials were searched up to January 2008 to identify appropriate studies. The primary outcome measurements were plaque accumulation and gingivitis.
  
  
  RESULTS
  Independent screening of titles and abstracts of 3250 papers resulted in eight publications that met the criteria of eligibility. Mean values and standard deviations were obtained by data extraction. Descriptive comparisons are presented for brushing only or brushing and rinsing. Meta-analyses were performed when possible.
  
  
  CONCLUSIONS
  The existing evidence supports that CPC containing mouth rinses, when used as adjuncts to either supervised or unsupervised oral hygiene, provide a small but significant additional benefit in reducing plaque accumulation and gingival inflammation.
authors.affiliation: School of Dental Hygiene, INHOLLAND University of Applied Sciences, Amsterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Haps
authors.forename: D E
authors.initials: DE
authors.lastname: Slot
authors.forename: C E
authors.initials: CE
authors.lastname: Berchier
authors.forename: G A
authors.initials: GA
authors.lastname: Van der Weijden
mesh_terms: D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002594:Cetylpyridinium / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D012907:Smoking; D014099:Toothbrushing / Q000379:methods*
chemical_list: D000891:Anti-Infective Agents, Local; D009067:Mouthwashes; D002594:Cetylpyridinium