When sirtuins and NF-kappaB collide.
Both the sirtuins and certain transcription factors of the NF-kappaB/Rel family control aging-associated changes in gene expression. Kawahara et al. (2009) now show a requirement in mice for the sirtuin SIRT6 in dampening NF-kappaB-dependent gene expression, thus unveiling a potential link between inflammation, aging, and metabolism.
Natoli
Gioacchino
G
Department of Experimental Oncology, European Institute of Oncology (IEO), IFOM-IEO Campus, I-20139 Milan, Italy. gioacchino.natoli@ifom-ieo-campus.it
D000375:Aging / Q000378:metabolism*; D000818:Animals; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism*; D037761:Sirtuins / Q000378:metabolism*
D016328:NF-kappa B; C501860:Sirt6 protein, mouse; D037761:Sirtuins