title: Neonatal pneumococcal conjugate vaccine immunization primes T cells for preferential Th2 cytokine expression: a randomized controlled trial in Papua New Guinea.
abstract: The effects of neonatal immunization with 7-valent pneumococcal conjugate vaccine (7vPCV) on development of T-cell memory and general immune maturation were studied in a cohort of Papua New Guinean newborns. Neonatal 7vPCV priming (followed by a dose at 1 and 2 months of age) was associated with enhanced Th2, but not Th1, cytokine responses to CRM(197) compared to 7vPCV at 1 and 2 months of age only. T cell responses to non-7vPCV vaccine antigens were similar in all groups, but TLR-mediated IL-6 and IL-10 responses were enhanced in 7vPCV vaccinated compared to controls. Neonatal 7vPCV vaccination primes T cell responses with a polarization towards Th2 with no bystander effects on other T cell responses.
authors.affiliation: Telethon Institute for Child Health Research, Centre for Child Health Research, University of Western Australia, PO Box 855, West Perth, WA 6872, Australia. Anitav@ichr.uwa.edu.au
authors.forename: Anita H J
authors.initials: AH
authors.lastname: van den Biggelaar
authors.forename: Peter C
authors.initials: PC
authors.lastname: Richmond
authors.forename: William S
authors.initials: WS
authors.lastname: Pomat
authors.forename: Suparat
authors.initials: S
authors.lastname: Phuanukoonnon
authors.forename: Marie A
authors.initials: MA
authors.lastname: Nadal-Sims
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Devitt
authors.forename: Peter M
authors.initials: PM
authors.lastname: Siba
authors.forename: Deborah
authors.initials: D
authors.lastname: Lehmann
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Holt
mesh_terms: D002585:Cesarean Section; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000276:immunology; D010219:Papua New Guinea; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology; D012329:RNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013296:Streptococcus pneumoniae / Q000235:genetics; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage
chemical_list: D016207:Cytokines; D022242:Pneumococcal Vaccines; D012329:RNA, Bacterial; D014765:Viral Vaccines