mTOR: dissecting regulation and mechanism of action to understand human disease.
mTOR (mammalian target of rapamycin) is a highly conserved serine/threonine protein kinase that has roles in cell metabolism, cell growth and cell survival. Although it has been known for some years that mTOR acts as a hub for inputs from growth factors (in particular insulin and insulin-like growth factors), nutrients and cellular stresses, some of the mechanisms involved are still poorly understood. Recent work has implicated mTOR in a variety of important human pathologies, including cancer, Type 2 diabetes and neurodegenerative disorders, heightening interest and accelerating progress in dissecting out the control and functions of mTOR.
Goberdhan
Deborah C I
DC
Department of Physiology, Anatomy and Genetics, University of Oxford, South Parks Rd, Oxford OX1 3QX, UK. deborah.goberdhan@dpag.ox.ac.uk
Boyd
C A Richard
CA
D000596:Amino Acids / Q000378:metabolism; D004194:Disease; D006801:Humans; D009928:Organ Specificity; D011494:Protein Kinases / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors / Q000378:metabolism
D000596:Amino Acids; D014157:Transcription Factors; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases