Effects of NO-modulating agents on the development of acute painful reaction in rats.
Painful reaction of rats to intraperitoneal injections of L-arginine, Nw-nitro-L-arginine, and agmatine was studied on the model of formalin-induced inflammation. All drugs exhibited a dubious effect on the patterns of nociceptive behavior depending on the phase of painful reaction. The dynamics of nitrate/nitrite content in animal blood and serum indicated the presence of NO-dependent and NO-independent components in the mechanisms of pharmacological effects of these drugs.
Dyuizen
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IV
Laboratory of Pharmacology, A. V. Zhirmunskii Institute of Marine Biology, Far Eastern Division of Russian Academy of Sciences, Department of Pharmacology, Vladivostok State Medical University, Russia. duval@mail.ru
Lamash
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NE
D000376:Agmatine / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D005557:Formaldehyde; D007249:Inflammation / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008297:Male; D009569:Nitric Oxide / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D019335:Nitroarginine / Q000494:pharmacology*; D010146:Pain / Q000139:chemically induced* / Q000503:physiopathology; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry
D005557:Formaldehyde; D019335:Nitroarginine; D009569:Nitric Oxide; D000376:Agmatine; D001120:Arginine