title: Small animal models of kidney disease: a review.
abstract: Animal models of renal disease have provided valuable insights into the pathogenesis of acute and chronic kidney disease. Extension of these models to the mouse has become an increasingly important with the development of gene knockout and transgenic animals. In this review we discuss a range of models that can be used to mimic the mechanisms of human renal disease. While not perfect, the careful and ethical use of these models offers the opportunity to examine individual mechanisms in an accelerated time frame.
authors.affiliation: Department of Nephrology, The Royal Melbourne Hospital and Department of Medicine, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Tim D
authors.initials: TD
authors.lastname: Hewitson
authors.forename: Takahiko
authors.initials: T
authors.lastname: Ono
authors.forename: Gavin J
authors.initials: GJ
authors.lastname: Becker
mesh_terms: D032761:Animal Experimentation / Q000941:ethics; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology / Q000503:physiopathology