Prenatal ultrasonographic findings in "trisomy 13".
OBJECTIVE
To evaluate the accuracy of prenatal ultrasonographic diagnosis in fetuses with trisomy 13.


METHODS
The present study consisted of all fetuses diagnosed of trisomy 13 and delivered at Ramathibodi Hospital between 1997 and 2006.


RESULTS
There were 15 cases of trisomy 13. Twelve cases (80.0%) were detected by prenatal ultrasonographic examination, and 3 cases (20.0%) were missed. Mean maternal age was 31.4 years old. Sixty-six percent were diagnosed in 2" trimester (mean 19.4 weeks). The earliest gestational age for detection was 12 weeks 6 days. The most common abnormal ultrasonographic findings were holoprosencephaly (46.7%), and facial defects (40.0%).


CONCLUSIONS
The accuracy of prenatal sonographic diagnosis in trisomy 13 fetuses was 80%. The most sensitive prenatal ultrasonographic findings in trisomy 13 were holoprosencephaly and facial defects.
Pitukkijronnakorn
Somsri
S
Department of Obstetrics & Gynaecology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand. somsri2005p@yahoo.com
Promsonthi
Patama
P
Panburana
Panyu
P
Rangsiprakarn
Rasig
R
Chittacharoen
Apichart
A
D000328:Adult; D002869:Chromosome Aberrations; D002882:Chromosomes, Human, Pair 13 / Q000235:genetics*; D005145:Face / Q000002:abnormalities; D005260:Female; D005865:Gestational Age; D016142:Holoprosencephaly / Q000175:diagnosis / Q000235:genetics; D006801:Humans; D011247:Pregnancy; D012307:Risk Factors; D014314:Trisomy / Q000175:diagnosis* / Q000235:genetics; D016216:Ultrasonography, Prenatal / Q000706:statistics & numerical data*