title: Association between p53 codon 72 genetic polymorphism and tobacco use and lung cancer risk.
abstract: Lung cancer (LCa) is the leading cause of death by cancer in men. Genetic and environmental factors play a synergistic role in its etiology. We explore in 111 lung cancer cases and 133 unrelated noncancer controls the gene-environment interaction (G x E) between p53cd72 polymorphism variants and smoking and the effect on LCa risk in two kinds of case-control designs. We assessed the interaction odds ratio (IOR) using an adjusted unconditional logistic model. We found a significant and positive interaction association between Pro* allele carriers and smoking habits in both case-control and case-only designs: IOR = 3.90 (95% confidence interval [CI] = 1.10-13.81) and 3.05 (95% CI = 1.63-5.72), respectively. These exploratory results suggest a synergistic effect of the smoking habit and the susceptibility of the Pro allele on lung cancer risk compared with each risk factor alone.
authors.affiliation: Epidemiology Division, School of Public Health, Faculty of Medicine, University of Chile, Independencia 939, P.O. Box 8380453, Santiago, Chile. dcaceres@med.uchile.cl
authors.forename: Dante D
authors.initials: DD
authors.lastname: Cáceres
authors.forename: Luis A
authors.initials: LA
authors.lastname: Quiñones
authors.forename: Jane C
authors.initials: JC
authors.lastname: Schroeder
authors.forename: Leonel D
authors.initials: LD
authors.lastname: Gil
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Irarrázabal
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D002677:Chile; D003062:Codon; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000209:etiology* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D018570:Risk Assessment; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: D003062:Codon; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53