Adipokines and systemic lupus erythematosus: relationship with metabolic syndrome and cardiovascular disease risk factors.
OBJECTIVE
To study concentrations of adipokines in patients with systemic lupus erythematosus (SLE) and the relationship among adipokines, the metabolic syndrome (MeS), and cardiovascular disease (CVD) risk factors.


METHODS
We enrolled 50 SLE patients and 26 controls, all women. Leptin, resistin, visfatin, and adiponectin were measured by commercial ELISA kits.


RESULTS
MeS prevalence was increased among subjects with SLE. Leptin levels were higher in patients with SLE than controls. Among SLE patients, independent determinants of leptin were insulin levels (p < 0.0001), triglycerides (p = 0.03), body mass index (p = 0.02), corticosteroid dosage (p = 0.02), and SLE Disease Activity Index (p = 0.005). Other adipokines did not differ between SLE patients and controls.


CONCLUSIONS
Leptin was increased in SLE patients and could play a role in SLE-related cardiovascular diseases.
Vadacca
Marta
M
Department of Clinical Medicine and Rheumatology, University "Campus Bio-Medico" of Rome, Via Alvaro del Portillo 200, 00128 Rome, Italy.
Margiotta
Domenico
D
Rigon
Amelia
A
Cacciapaglia
Fabio
F
Coppolino
Giusy
G
Amoroso
Antonio
A
Afeltra
Antonella
A
D054392:Adipokines / Q000032:analysis / Q000097:blood*; D052242:Adiponectin / Q000032:analysis / Q000097:blood; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D015992:Body Mass Index; D015897:Comorbidity; D016207:Cytokines / Q000032:analysis / Q000097:blood; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007328:Insulin / Q000032:analysis / Q000097:blood; D020738:Leptin / Q000032:analysis / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000453:epidemiology* / Q000276:immunology*; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology* / Q000276:immunology*; D054409:Nicotinamide Phosphoribosyltransferase / Q000032:analysis / Q000097:blood; D011237:Predictive Value of Tests; D052243:Resistin / Q000032:analysis / Q000097:blood; D014280:Triglycerides / Q000032:analysis / Q000097:blood; D015854:Up-Regulation / Q000502:physiology
C499918:ADIPOQ protein, human; D054392:Adipokines; D052242:Adiponectin; D000305:Adrenal Cortex Hormones; D015415:Biomarkers; D016207:Cytokines; D007166:Immunosuppressive Agents; D007328:Insulin; D020738:Leptin; D052243:Resistin; D014280:Triglycerides; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human