Clinical applications of metabolomics in oncology: a review.
Metabolomics, an omic science in systems biology, is the global quantitative assessment of endogenous metabolites within a biological system. Either individually or grouped as a metabolomic profile, detection of metabolites is carried out in cells, tissues, or biofluids by either nuclear magnetic resonance spectroscopy or mass spectrometry. There is potential for the metabolome to have a multitude of uses in oncology, including the early detection and diagnosis of cancer and as both a predictive and pharmacodynamic marker of drug effect. Despite this, there is lack of knowledge in the oncology community regarding metabolomics and confusion about its methodologic processes, technical challenges, and clinical applications. Metabolomics, when used as a translational research tool, can provide a link between the laboratory and clinic, particularly because metabolic and molecular imaging technologies, such as positron emission tomography and magnetic resonance spectroscopic imaging, enable the discrimination of metabolic markers noninvasively in vivo. Here, we review the current and potential applications of metabolomics, focusing on its use as a biomarker for cancer diagnosis, prognosis, and therapeutic evaluation.
Spratlin
Jennifer L
JL
Department of Medical Oncology, University of Colorado Health Sciences Center, Denver, Colorado, USA. jennspra@cancerboard.ab.ca
Serkova
Natalie J
NJ
Eckhardt
S Gail
SG
D014408:Biomarkers, Tumor / Q000378:metabolism*; D019295:Computational Biology; D055808:Drug Discovery; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008495:Medical Oncology / Q000639:trends*; D055442:Metabolome; D055432:Metabolomics / Q000379:methods*; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000628:therapy*; D010641:Phenotype; D049268:Positron-Emission Tomography; D049490:Systems Biology / Q000379:methods*
D014408:Biomarkers, Tumor