Acquired factor VII deficiency associated with Wilms tumor.
We present the case of a 2-year-old female with Wilms tumor whose initial evaluation revealed a prolonged prothrombin time (PT) and normal activated partial thromboplastin time. Mixing studies demonstrated correction of the PT and the Factor VII activity was 17% in the absence of a Factor VII inhibitor. She underwent successful resection of the tumor with fresh frozen plasma support and no excessive bleeding. Post-operative testing demonstrated normal PT at 3 days and 1-month. Although acquired von Willebrand factor deficiency has a known association with Wilms tumor, paraneoplastic factor VII deficiency associated with Wilms tumor is previously unreported.
Granger
Jeremy
J
Department of Pediatrics, Wilford Hall Medical Center, Lackland AFB, Texas 78236, USA. jeremy.granger@lackland.af.mil
Gidvani
Vinod K
VK
D002675:Child, Preschool; D005167:Factor VII / Q000378:metabolism; D005168:Factor VII Deficiency / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D009396:Wilms Tumor / Q000150:complications* / Q000378:metabolism / Q000601:surgery
D005167:Factor VII