title: Ionic liquids promote amyloid formation from alpha-synuclein.
abstract: The slow process required for alpha-synuclein to form amyloid fibrils is a major obstacle in the development of therapeutic compounds for alpha-synuclein-related neurodegenerative diseases such as Parkinson's disease (PD). Here we have developed an efficient method by which amyloid fibrils can be formed from alpha-synuclein using ionic liquids (ILs). This report indicates that ILs could potentially be used as a stimulator for the amyloid formation of alpha-synuclein.
authors.affiliation: Department of Molecular Science and Technology, Graduate School of Interdisciplinary Program, Ajou University, Suwon 443-749, Republic of Korea.
authors.forename: Heejin
authors.initials: H
authors.lastname: Hwang
authors.forename: Hyunghun
authors.initials: H
authors.lastname: Choi
authors.forename: Hyun-Kyung
authors.initials: HK
authors.lastname: Kim
authors.forename: Do Hyun
authors.initials: DH
authors.lastname: Jo
authors.forename: T Doohun
authors.initials: TD
authors.lastname: Kim
mesh_terms: D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D052578:Ionic Liquids / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D051844:alpha-Synuclein / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000682:Amyloid; D052578:Ionic Liquids; D051844:alpha-Synuclein