title: [Thyroid disorders during pregnancy].
abstract: Thyroid disorders may not only be the cause infertility but also increases the incidence of miscarriages and the morbidity of the pregnancies. During pregnancy the demand of thyroid hormones increases to about 30 - 50 % and the thyroid has to cope with this increase. In Germany the iodine intake has improved significantly during the last 20 years, but still is borderline low with an mean intake of about 120 microg iodide per day. Therefore it is still recommended that pregnant women are supplemented with about 100 - 150 microg of iodide during pregnancy and the time of breast-feeding, to avoid hypothyroidism of the foetus with concomitant delay of the brain development. Not only women with subclinical hypothyroidism, but only elevated TPO antibodies have a significant increase in early miscarriage and preterm delivery. An early supplementation with Levothyroxin despite euthyroidism might reduce these risks. Those women also more frequently develop postpartum thyroiditis. This risk can be reduced by a supplementation with selenium during and after pregnancy. Graves' disease is a rare disorder and only about 0,1 - 0,4 pregnancies are affected. The course of the disease is biphasic, with an exacerbation within the first trimester and an improvement thereafter, but a recurrence after delivery. Overt thyrotoxicosis has to be treated with propylthiouracil, to maintain euthyroidism during pregnancy. The TSH receptor antibodies are transferred to the foetus with the risk of thyrotoxicosis. Special care of the foetus is therefore necessary. Transient mild hyperthyroidism may occur in women with very high HCG levels during the first three months of pregnancy. This often is associated with hyperemesis gravidarum. Subclinical hypothyroidism of the mother will disturb the normal development of the foetus and therefore has to be treated even when TSH is within the upper normal level. Special care is necessary in women with elevated TPO antibodies, because these more often develop postpartum thyroiditis.
authors.affiliation: Medizinische Klinik Innenstadt der Universität München. roland.gaertner@med.uni-muenchen.de
authors.forename: R
authors.initials: R
authors.lastname: Gärtner
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000517:prevention & control; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications / Q000188:drug therapy; D007037:Hypothyroidism / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control; D007247:Infertility, Female / Q000209:etiology; D007454:Iodides / Q000627:therapeutic use; D007455:Iodine / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy / Q000209:etiology*; D047928:Premature Birth / Q000209:etiology; D011644:Puerperal Disorders / Q000517:prevention & control; D012307:Risk Factors; D018036:Selenium Compounds / Q000627:therapeutic use; D013959:Thyroid Diseases / Q000150:complications* / Q000188:drug therapy; D013963:Thyroid Hormones / Q000627:therapeutic use; D013966:Thyroiditis / Q000517:prevention & control; D013967:Thyroiditis, Autoimmune / Q000209:etiology; D013971:Thyrotoxicosis / Q000209:etiology / Q000517:prevention & control
chemical_list: D007454:Iodides; D018036:Selenium Compounds; D013963:Thyroid Hormones; D007455:Iodine