Alterations of coagulation in metformin intoxication.
It is widely known that metformin reduces the levels of circulating pro-coagulant factors and improve fibrinolytic activity in type 2 diabetes when used in therapeutic doses. Potential alterations of coagulation have not been reported in patients with metformin intoxication. We evaluated certain components of the coagulation system in a patient with metformin intoxication upon admission and after recovery. Our results indicate that both the levels of coagulation proteins synthesized by the liver and the anti-coagulant activity decrease temporarily in metformin intoxication. Nevertheless, no change in the coagulation factors secreted by the endothelium were observed.
Akinci
Baris
B
Division of Endocrinology and Metabolism, Dokuz Eylul University Medical School, Inciralti, Izmir, Turkey. baris.akinci@deu.edu.tr
Yener
Serkan
S
Bengi
Goksel
G
Yesil
Sena
S
D000138:Acidosis / Q000209:etiology / Q000628:therapy; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000506:poisoning; D007260:Infusion Pumps; D008687:Metformin / Q000506:poisoning*; D011041:Poisoning / Q000097:blood* / Q000150:complications / Q000628:therapy; D006435:Renal Dialysis; D017693:Sodium Bicarbonate / Q000008:administration & dosage; D013406:Suicide, Attempted; D055815:Young Adult
D007004:Hypoglycemic Agents; D017693:Sodium Bicarbonate; D008687:Metformin