title: Initial experience in Brazil with endoscopic submucosal dissection for early gastric cancer using insulation-tipped knife: a safety and feasibility study.
abstract: BACKGROUND
  Endoscopic resection is an adequate treatment for subgroups of patients with early gastric cancer. Endoscopic submucosal dissection (ESD) represents a recent advance and leads to good results when adequately indicated. There is great experience with this technique in Japan and it is gaining acceptance among Western endoscopists. We present the first gastric ESD series performed in Brazil.
  
  
  METHODS
  Patients with well-differentiated adenocarcinomas macroscopically classified as early cancer, less than 30 mm with no ulcer or scar, were included. ESD was performed with an insulated-tip knife and electrosurgical unit with endocut mode. Clinicopathological aspects and morbidity were evaluated. The study was approved by the local ethics committee and informed consent was obtained from all participant subjects.
  
  
  RESULTS
  From October 2005 to July 2007, 160 patients received surgical treatment for gastric cancer; 44 patients (27.5%) had early gastric cancer. In this latter group, 15 procedures (ESD) were performed in 12 patients. The mean size of the lesions was 16.8 mm. Almost half of the lesions were located in the proximal third of the stomach and the mean elapsed time for the procedure was 140 min. In 80% of the cases resection was en bloc and 80% of the resections were considered curative. We had three perforations, which were managed clinically, and no bleeding.
  
  
  CONCLUSIONS
  When adequately indicated, ESD is a safe and feasible technique.
authors.affiliation: Endoscopic Unit, Department of Gastrointestinal Oncology, Araújo Jorge Cancer Hospital, Rua 239, No. 181, Setor Universitário, CEP, 74605-070 Goiânia, GO, Brazil.
authors.forename: Daniela Medeiros Milhomem
authors.initials: DM
authors.lastname: Cardoso
authors.forename: Paulo Moacir de Oliveira
authors.initials: PM
authors.lastname: Campoli
authors.forename: Chizu
authors.initials: C
authors.lastname: Yokoi
authors.forename: Flávio Hayato
authors.initials: FH
authors.lastname: Ejima
authors.forename: Paulo Adriano de Queiroz
authors.initials: PA
authors.lastname: Barreto
authors.forename: Alexandre Menezes
authors.initials: AM
authors.lastname: de Brito
authors.forename: Eliane Duarte
authors.initials: ED
authors.lastname: Mota
authors.forename: Ailton Cabral
authors.initials: AC
authors.lastname: de Fraga Júnior
authors.forename: Orlando Milhomem
authors.initials: OM
authors.lastname: da Mota
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D004724:Endoscopy / Q000009:adverse effects / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology; D007564:Japan; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome