Animal models of human type 1 diabetes.
Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta cells are damaged and destroyed. Animal models have served a prominent function in the development of the present ideas of pathogenesis and approaches to therapy. This commentary addresses the utility and limitations of these models for facilitating the 'translation' of immunology research into clinical applications.
von Herrath
Matthias
M
Center for Type 1 Diabetes Research, La Jolla Institute for Allergy and Immunology, La Jolla, California 92037, USA. matthias@liai.org
Nepom
Gerald T
GT
D000818:Animals; D003922:Diabetes Mellitus, Type 1; D004195:Disease Models, Animal; D006801:Humans