Recurrent stroke in a child with incontinentia pigmenti.
We report a child with genetically proven incontinentia pigmenti who had bilateral strokes at 5 days of age, and was subsequently found to have recurrent acute strokes on magnetic resonance imaging both at 10 days and 3 months of age. Brain magnetic resonance imaging at 5 days of age showed multiple areas of restricted diffusion throughout both hemispheres. The child was started on antiplatelet therapy after a second stroke was noted on magnetic resonance imaging at 10 days of age. Despite this treatment, she had a third punctate infarct on magnetic resonance imaging 3 months later. A magnetic resonance imaging at 10 months of age showed maturation of the old infarcts but no new strokes. The purpose of this article is to describe a unique presentation of recurrent stroke secondary to incontinentia pigmenti and to highlight the need for a better understanding of the pathophysiology of incontinentia pigmenti to develop appropriate treatment of stroke in incontinentia pigmenti.
Cartwright
Michael S
MS
Department of Neurology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. mcartwri@wfubmc.edu
White
David L
DL
Miller
Lewis M
LM
Roach
E Steve
ES
D001241:Aspirin / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology; D005260:Female; D006801:Humans; D007184:Incontinentia Pigmenti / Q000150:complications* / Q000473:pathology; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012008:Recurrence; D020521:Stroke / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin