[Correlation between echographic cardiac measurements and hemoglobin deficit in fetus of red cell alloimmunized pregnancies].
OBJECTIVE
to verify the correlation between ultrasonography heart measures and hemoglobin deficit in fetuses of alloimmunized pregnant women.


METHODS
a transversal study, including 60 fetuses, with 21 to 35 weeks of gestational age, from 56 isoimmunized pregnant women. A number of 139 procedures were performed. Before cordocentesis for the collection of fetal blood, cardiac measures and femur length (FL) were assessed by ultrasonography. The external biventricular diameter (EBVD) was obtained by measuring the distance between the epicardic external parts at the end of the diastole, with the M-mode cursor perpendicular to the interventricular septum, in the atrioventricular valves. The measure of the atrioventricular diameter (AVD) was obtained by positioning the same cursor along the interventricular septum, evaluating the distance between the heart basis and apex. The FL was determined from the trochanter major to the distal metaphysis. The cardiac circumference (CC) was also calculated. To adjust the cardiac measure to the gestational age, each of these measures were divided by the FL measure. Hemoglobin concentration has been determined by spectrophotometry with the Hemocue system. Hemoglobin deficit calculation was based in the Nicolaides's normality curve.


RESULTS
direct and significant correlations were observed between the cardiac measures evaluated and the hemoglobin deficit. To predict moderate and severe anemia, the sensitivity and specificity found were 71.7 and 66.3% for EBVD and FL, 65.8 and 62.4% for AVD and FL, and 73.7 and 60.4% for CC and FL, respectively.


CONCLUSIONS
ultrasonography cardiac measures assessed from fetuses of isoimmunized pregnant women correlate directly with hemoglobin deficit.
Hanan
Marília Zicker
MZ
Departamento de Ginecologia e Obstetrícia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil. mzhanan@uai.com.br
Cabral
Antônio Carlos Vieira
AC
Pereira
Alamanda Kfoury
AK
Leite
Henrique Vitor
HV
Reis
Zilma Nogueira
ZN
D000328:Adult; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging*; D006454:Hemoglobins / Q000172:deficiency*; D006801:Humans; D011247:Pregnancy; D012203:Rh Isoimmunization; D016216:Ultrasonography, Prenatal
D006454:Hemoglobins