title: Expression modes and clinical manifestations of latent membrane protein 1, Ki-67, cyclin-B1, and epidermal growth factor receptor in nonendemic nasopharyngeal carcinoma.
abstract: BACKGROUND
  We aimed to identify clinical significance of latent membrane protein 1 (LMP1), Ki-67, cyclin-B1, and epidermal growth factor receptor (EGFR), in nonendemic nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  The relation between expression of the markers in 45 NPC specimens and clinicopathological and survival variables was statistically analyzed.
  
  
  RESULTS
  LMP1 was present in 33% of the tumors, and its presence was associated with advanced nodal and disease stages. Overexpression was defined as labeling index > or = median value for Ki-67, > or = 15% for cyclin-B1, and > or =50% for EGFR, and it was displayed in 50%, 55%, and 80% of the specimens, respectively. Strong EGFR staining intensity and not overexpression of the 3 markers was the variable with statistically significant impact on treatment outcomes in terms of worse local and locoregional tumor control rates.
  
  
  CONCLUSIONS
  Our results suggest that the evaluation of EGFR staining intensity in patients with NPC may identify a subgroup of patients with poor prognosis.
authors.affiliation: Department of Oncology, Sahlgrenska University Hospital, Göteborg, Sweden. zahra.taherikadkhoda@vgregion.se
authors.forename: Zahra
authors.initials: Z
authors.lastname: Taheri-Kadkhoda
authors.forename: Bengt
authors.initials: B
authors.lastname: Magnusson
authors.forename: Marie
authors.initials: M
authors.lastname: Svensson
authors.forename: Claes
authors.initials: C
authors.lastname: Mercke
authors.forename: Thomas
authors.initials: T
authors.lastname: Björk-Eriksson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism*; D002648:Child; D019926:Cyclin B / Q000378:metabolism*; D056744:Cyclin B1; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism*; D014763:Viral Matrix Proteins / Q000032:analysis*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; C534699:CCNB1 protein, human; D019926:Cyclin B; D056744:Cyclin B1; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D019394:Ki-67 Antigen; D014763:Viral Matrix Proteins; D066246:ErbB Receptors