Obesity and activated protein C resistance.
It has been reported that obesity may be associated with activated protein C resistance, which could increase the thrombotic risk in these patients. The aim of our study was to evaluate this parameter in obese patients and controls, as well as the effect of weight loss on this parameter. In 63 severely or morbidly obese patients and in 65 healthy volunteers, an anthropometric and analytical evaluation (activated protein C resistance and prothrombin fragment F1 + 2) was performed at baseline and after 3 months of diet. Obese patients showed higher levels of F1 + 2 than controls, whereas activated protein C sensitivity ratios showed no differences. After weight loss, prothrombin fragment F1 + 2 was reduced, but no differences were found in activated protein C sensitivity. We did not find an activated protein C-resistant phenotype in obese subjects.
Solá
Eva
E
Endocrinology Department, Doctor Peset University Hospital, School of Medicine, Valencia University, Valencia, Spain. eva.sola@uv.es
Vayá
Amparo
A
Villa
Piedad
P
España
Francisco
F
Estellés
Amparo
A
García
Katherinne
K
Hernández-Mijares
Antonio
A
D020016:Activated Protein C Resistance / Q000097:blood*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications*; D009767:Obesity, Morbid / Q000097:blood / Q000150:complications; D010446:Peptide Fragments / Q000097:blood; D011516:Prothrombin; D015431:Weight Loss; D055815:Young Adult
D010446:Peptide Fragments; C045879:prothrombin fragment 1.2; D011516:Prothrombin