Selective white matter involvement in a patient with late onset Krabbe disease: MR, MR spectroscopy, and diffusion tensor study.
The most frequent type of Krabbe disease has an infantile onset. Unusual slowly progressive adult forms have also been described. We described a different involvement of white matter tracts where magnetic resonance signal alterations were evident in a case of a patient affected by late-onset form of disease.
Romano
Andrea
A
Department of Neuroradiology, S. Andrea Hospital, University "La Sapienza", Rome, Italy. andrea.romano@uniroma1.it
De Simone
Roberto
R
Fasoli
Fabrizio
F
Ferrante
Michele
M
Cipriani
Valentina
V
Fantozzi
Luigi Maria
LM
Bozzao
Alessandro
A
D000328:Adult; D017668:Age of Onset; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007965:Leukodystrophy, Globoid Cell / Q000378:metabolism* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009413:Nerve Fibers, Myelinated / Q000378:metabolism* / Q000473:pathology*; D009434:Neural Pathways / Q000378:metabolism / Q000473:pathology