title: Tuberous sclerosis complex with unilateral perisylvian polymicrogyria and contralateral hippocampal sclerosis - a case report.
abstract: Malformations of cortical development (MCD) encompass a wide spectrum of brain disorders. Although rare, the combination of certain MCD may occur. We report a rare case of combination of three distinct cerebral pathologies: tuberous sclerosis, polymicrogyria and hippocampal sclerosis in a patient with intractable epilepsy. Ictal EEG and ictal SPECT suggested right perisylvian area as a seizure onset zone. However, on MRI multiple potentially epileptogenic lesions were identified. The neurobiological background of the coexistence of different types of malformations of cortical development remains enigmatic.
authors.affiliation: Department of Neurology, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. raimund.helbok@uki.at
authors.forename: R
authors.initials: R
authors.lastname: Helbok
authors.forename: G
authors.initials: G
authors.lastname: Kuchukhidze
authors.forename: I
authors.initials: I
authors.lastname: Unterberger
authors.forename: F
authors.initials: F
authors.lastname: Koppelstaetter
authors.forename: J
authors.initials: J
authors.lastname: Dobesberger
authors.forename: E
authors.initials: E
authors.lastname: Donnemiller
authors.forename: E
authors.initials: E
authors.lastname: Trinka
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006624:Hippocampus / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D055909:Magnetic Field Therapy; D054220:Malformations of Cortical Development / Q000150:complications* / Q000000981:diagnostic imaging; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D014402:Tuberous Sclerosis / Q000150:complications* / Q000000981:diagnostic imaging; D055815:Young Adult