Acid-base balance and oxygen tension during dialysis in uremic patients with chronic obstructive pulmonary disease.
Recent reports on the effects of dialysis on acid-base balance and metabolic acidosis correction in end-stage renal disease (ESRD) patients with chronic obstructive pulmonary disease (COPD) are lacking. Here, we compared acid-base balance and blood gasses among 14 patients with established COPD (group A) and eight patients with normal respiratory function (group B). The two groups were homogeneous for age, time on dialysis, and male/female ratio. At the beginning of dialysis, acid-base balance and blood gasses were comparable between patients of groups A and B. A significant difference between groups was observed only in pCO(2) at 20 min, together with a delay in pH increase. Effective correction of acidosis was reported at the end of dialysis and is not significantly affected by COPD. Nevertheless, weight loss must be carefully monitored in these patients in order to prevent hyperhydration and worsening of respiratory function.
Manca-Di-Villahermosa
Simone
S
Nephrology-Department of Internal Medicine, Tor Vergata University, Rome, Italy.
Tedesco
Michela
M
Lonzi
Maurizio
M
Della-Rovere
Francesca R
FR
Innocenzi
Anna
A
Colarieti
Giovanni
G
Favarò
Antonio
A
Chamoun
Gebran M
GM
Taccone-Gallucci
Massimo
M
D000136:Acid-Base Equilibrium; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000097:blood* / Q000150:complications; D006435:Renal Dialysis / Q000009:adverse effects*; D012737:Sex Factors; D013997:Time Factors; D014511:Uremia / Q000097:blood* / Q000150:complications
D001639:Bicarbonates