title: Pulmonary capillary wedge pressure and pulmonary arterial pressure in heart failure patients with sleep-disordered breathing.
abstract: BACKGROUND
  There is a high prevalence of central sleep apnea (CSA) in patients with chronic heart failure (CHF). The present study investigates the hypotheses that CSA in CHF patients reflects heart failure severity as measured by cardiac index (CI), pulmonary artery pressure (PAP) and pulmonary capillary wedge pressure (PCWP).
  
  
  METHODS
  In 105 patients with stable CHF (NYHAII, LV-EF40%) cardiorespiratory polygraphy and simultaneous right and left heart catheterization was performed.
  
  
  RESULTS
  CSA was present in 58% and obstructive sleep apnea (OSA) in 23% of patients. In CSA patients, PAP and PCWP were significantly higher when compared to patients without SDB. In CSA patients, but not in OSA patients, PCWP showed a significant correlation with apnea-hypopnea index (AHI; r=0.41, p=0.005), apnea index (AI; r=0.44, p=0.003) and central AI (cAI; r=0.358, p=0.015). Cardiac index was more impaired in CSA (1.93+/-0.5 l/min/m(2)) than in OSA patients (2.55+/-1.0 l/min/m(2)) or those without SDB (2.22+/-0.4 l/min/m(2)). A negative correlation of CI and cAI (r=-0.344, p=0.008), AI (r=-0.31, p=0.02) and AHI (r=-0.21, p<0.05) was documented exclusively in CSA patients.
  
  
  CONCLUSIONS
  The present study supports the hypotheses that the occurrence and severity of CSA in CHF patients reflects heart failure severity.
authors.affiliation: Department of Cardiology, Heart and Diabetes Center North Rhine-Westphalia, Ruhr University Bochum, Georgstrasse 11, D-32545 Bad Oeynhausen, Germany. ooldenburg@hdz-nrw.de
authors.forename: Olaf
authors.initials: O
authors.lastname: Oldenburg
authors.forename: Thomas
authors.initials: T
authors.lastname: Bitter
authors.forename: Marcus
authors.initials: M
authors.lastname: Wiemer
authors.forename: Christoph
authors.initials: C
authors.lastname: Langer
authors.forename: Dieter
authors.initials: D
authors.lastname: Horstkotte
authors.forename: Cornelia
authors.initials: C
authors.lastname: Piper
mesh_terms: D001784:Blood Gas Analysis; D001921:Brain / Q000378:metabolism; D002196:Capillaries; D004562:Electrocardiography; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006333:Heart Failure / Q000473:pathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D045265:Natriuretic Peptides / Q000097:blood; D015995:Prevalence; D011669:Pulmonary Wedge Pressure / Q000502:physiology*; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000453:epidemiology*; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000453:epidemiology
chemical_list: D045265:Natriuretic Peptides