title: Concentrations of very long-chain fatty acid in whole blood are associated with cardiovascular risk factors in children.
abstract: BACKGROUND
  Fatty acid metabolism has a close relationship with metabolic syndrome. Saturated very long-chain fatty acid (hexacosanoic acid; C26:0) was recently reported to be associated with cardiovascular risk factors in adults.
  
  
  METHODS
  Eighty-eight children (47 male, 41 female; average age, 10.9 y) participated in this study. Concentrations of C26:0 in whole blood were measured.
  
  
  RESULTS
  Compared with reported concentrations in the whole blood of adults, children had lower C26:0 concentrations, which had a close relationship with abdominal obesity, increased concentrations of low-density lipoprotein cholesterol and high blood pressure. C26:0 concentrations increased with increasing number of risk factors.
  
  
  CONCLUSIONS
  Elevation of C26:0 concentrations may be one of the metabolic features of children with cardiovascular risk factors.
authors.affiliation: Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Okahashi
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okada
authors.forename: Emiko
authors.initials: E
authors.lastname: Saito
authors.forename: Michio
authors.initials: M
authors.lastname: Miyashita
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuromori
authors.forename: Fujihiko
authors.initials: F
authors.lastname: Iwata
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Hara
authors.forename: Hideo
authors.initials: H
authors.lastname: Mugishima
authors.forename: Yohei
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D002648:Child; D008078:Cholesterol, LDL / Q000097:blood; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology; D008297:Male; D009765:Obesity / Q000097:blood / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D008078:Cholesterol, LDL; D005227:Fatty Acids; C017364:hexacosanoic acid