Serum nutrients and habitual dietary intake in colectomized FAP patients in Norway.
BACKGROUND
Patients with familial adenomatous polyposis (FAP) are colectomized in young age in order to avoid development of colorectal cancer. Because colectomy radically changes gastrointestinal physiology, and food avoidance may be present, colectomized patients may be at risk for nutritional deficiency.


OBJECTIVE
to evaluate: (1) serum biochemical levels as compared to reference; (2) dietary intake as compared to the recommendations.


METHODS
Blood samples, interviews and food frequency questionnaire were collected from 38 colectomized FAP patients with duodenal adenomas (mean age 40 years, range: 24-70). They were recruited from the Norwegian database on FAP.


RESULTS
Serum albumin was significantly higher (P < or = 0.0001), and Mg (P = 0.02), ferritin (P < or = 0.001), and cholesterol (P = 0.03) significantly lower, than reference levels. Compared to recommendations, a low intake was seen for folate and fiber (<50%), iron, thiamin, riboflavin (< 25%), and omega-3 fatty acids (8%). Sugar intake exceeded the recommendation, mainly due to a high intake of soft drinks. Food avoidance was reported by 53%.


CONCLUSIONS
We would suggest that the nutrient intake among FAP patients should at least meet the recommendations for healthy subjects. Their risk of metachronous cancers should also cause special attention to dietary factors that may prevent nutritional deficiency and carcinogenesis.
Almendingen
Kari
K
Unit of Clinical Research, Research Center, Akershus University Hospital, Box 95, 1478 Lørenskog, Norway. kari.almendingen@ahus.no
Fausa
Olau
O
Høstmark
Arne Tore
AT
Bratlie
Jorunn
J
Mørkerid
Lars
L
Aabakken
Lars
L
Vatn
Morten Harald
MH
D011125:Adenomatous Polyposis Coli / Q000097:blood* / Q000601:surgery*; D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D003082:Colectomy; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D004043:Dietary Fiber / Q000008:administration & dosage; D004311:Double-Blind Method; D002149:Energy Intake; D015525:Fatty Acids, Omega-3; D005247:Feeding Behavior; D005293:Ferritins / Q000097:blood; D005492:Folic Acid / Q000008:administration & dosage; D006801:Humans; D007501:Iron / Q000008:administration & dosage; D008274:Magnesium / Q000097:blood; D008875:Middle Aged; D009664:Norway; D009751:Nutritional Requirements; D009752:Nutritional Status; D010919:Placebos; D012256:Riboflavin / Q000008:administration & dosage; D012709:Serum Albumin / Q000032:analysis; D013831:Thiamine / Q000008:administration & dosage
D004040:Dietary Carbohydrates; D004043:Dietary Fiber; D015525:Fatty Acids, Omega-3; D010919:Placebos; D012709:Serum Albumin; D005293:Ferritins; D005492:Folic Acid; D002784:Cholesterol; D007501:Iron; D008274:Magnesium; D012256:Riboflavin; D013831:Thiamine