Pro32Thr polymorphism of inosine triphosphate pyrophosphatase gene predicts efficacy of low-dose azathioprine for patients with systemic lupus erythematosus.
We evaluated the relationship between the efficacy of low-dose azathioprine (AZA) therapy and the inosine triphosphate pyrophosphatase (ITPA) 94C>A (Pro32Thr) polymorphism in patients with systemic lupus erythematosus (SLE). We performed a multiple regression analysis to assess the influence of various factors on the reduction in SLE disease activity index (SLEDAI) scores. The ITPA 94C>A polymorphism had the highest correlation with the change in SLEDAI score (r = 0.354, P = 0.006).
Okada
Y
Y
Department of Clinical Pharmacology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Nakamura
K
K
Hiromura
K
K
Nojima
Y
Y
Horiuchi
R
R
Yamamoto
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics; D001379:Azathioprine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007564:Japan / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D008780:Methyltransferases / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011755:Pyrophosphatases / Q000235:genetics*; D012044:Regression Analysis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult; D000097630:Inosine Triphosphatase
D001379:Azathioprine; D005982:Glutathione Transferase; D007166:Immunosuppressive Agents; D008780:Methyltransferases; D011755:Pyrophosphatases; D000097630:Inosine Triphosphatase; C022745:thiopurine methyltransferase