Hematopoietic stem cell quiescence: yet another role for p53.
p53, sometimes referred to as the "guardian of the genome," helps regulate cell-cycle arrest, DNA-damage repair, apoptosis, and senescence. Adding to this list, in this issue of Cell Stem Cell, Liu et al. (2009) show that p53 also plays a role in regulating hematopoietic stem cell quiescence.
van Os
Ronald
R
Department of Cell Biology, Section Stem Cell Biology, University Medical Center Groningen, 9713 AV Groningen, the Netherlands.
de Haan
Gerald
G
Dykstra
Brad J
BJ
D000818:Animals; D049109:Cell Proliferation; D050759:Cyclin-Dependent Kinase Inhibitor p21 / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000172:deficiency / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism; D014157:Transcription Factors / Q000172:deficiency / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D050759:Cyclin-Dependent Kinase Inhibitor p21; D004268:DNA-Binding Proteins; C491779:Elf4 protein, mouse; C079873:Gfi1 protein, mouse; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53; C069766:necdin