title: Functional analysis of insertion sequence ISAba1, responsible for genomic plasticity of Acinetobacter baumannii.
abstract: ISAba1 is an insertion sequence that is widely distributed in Acinetobacter baumannii. We demonstrated here that ISAba1 and the composite transposon Tn2006 are capable of transposition, generating 9-bp target site duplications. The expression of the ISAba1 transposase-encoding gene was downregulated by translational frameshifting.
authors.affiliation: Service de Bactériologie-Virologie, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France.
authors.forename: Pauline D
authors.initials: PD
authors.lastname: Mugnier
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D040981:Acinetobacter baumannii / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D001483:Base Sequence; D004251:DNA Transposable Elements; D016368:Frameshift Mutation; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D011995:Recombination, Genetic; D016415:Sequence Alignment; D019895:Transposases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D019895:Transposases