Oral contraceptive pill containing drospirenone and the professional voice: an electrolaryngographic analysis.
Few studies have been concerned with the effects of combined oral contraceptive pills (OCP) on those who use their voices as a tool of trade. A cohort study involving 20 female professional voice users was carried out assessing irregularity of vocal fold vibration, based on: 1) period-to-period frequency peaks (CFx), and 2) period-to-period amplitude peaks (CAx) in the cycle-to-cycle excitation of the vocal tract. These vocal measures and blood samples were collected at three points of the menstrual cycle, for both natural and OCP cycles. No significant differences were found in vocal parameters assessed between the natural and OCP cycles. The intake of this OCP was not found to have a systematic effect on the vocal parameters studied. Based on these results the modern OCP preparations can be considered safe medications which do not have a negative effect on voice quality in professional voice users.
Lã
Filipa M B
FM
Music Department, University of Sheffield, Sheffield, UK.
Howard
David M
DM
Ledger
William
W
Davidson
Jane W
JW
Jones
Georgina
G
D000328:Adult; D000704:Analysis of Variance; D000736:Androstenes / Q000494:pharmacology*; D015331:Cohort Studies; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood; D014827:Vocal Cords / Q000187:drug effects; D014831:Voice / Q000187:drug effects* / Q000502:physiology; D055815:Young Adult
D000736:Androstenes; D003277:Contraceptives, Oral, Combined; D000451:Mineralocorticoid Receptor Antagonists; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; C035144:drospirenone