title: Clinical and angiographic results of coiling of 196 very small (< or = 3 mm) intracranial aneurysms.
abstract: OBJECTIVE
  Coiling of very small (< or = 3 mm) aneurysms is considered controversial because of technical difficulties and a higher rate of procedural aneurysm ruptures. In this study, we report clinical and angiographic results of coiling of aneurysms 3 mm or smaller in comparison with larger aneurysms in a large, single-center cohort of patients.
  
  
  METHODS
  Between 1995 and July 2008, a total of 1295 aneurysms were selectively occluded with coils. Of 1295 aneurysms, 196 (15.1%) in 187 patients were very small. Of 196 aneurysms, 149 (76%) had ruptured and 47 (24%) had not ruptured. There were 51 males (27%) and 136 females (73%). Mean age was 54.7 years (age range, 11-78 years).
  
  
  RESULTS
  Procedural morbidity rate was 2.1% and mortality rate, 1.1%. Procedural rupture occurred in 15 of 196 aneurysms (7.7%). In 13 of 15 procedural ruptures, this had no adverse effect on outcome. Early recurrent hemorrhage of the coiled aneurysm occurred in 2 patients (1.1%). Compared with larger aneurysms, in very small aneurysms more often a procedural rupture occurred (7.7% versus 3.6%; P = .018). Procedural morbidity rate was lower (3.2% versus 5.5%), but this was not significant (P = .26). Retreatment rate consisted predominantly of clipping soon after incomplete coiling and was lower than in larger aneurysms (5.1% versus 10.0%; P = .041). Other characteristics were not significantly different.
  
  
  CONCLUSIONS
  Coiling of very small aneurysms was technically feasible, with good results. Although procedural aneurysm rupture was significantly more frequent in very small aneurysms, this did not lead to increased overall morbidity and mortality rates. Retreatment rate was lower than for larger aneurysms.
authors.affiliation: Department of Radiology, St. Elisabeth Ziekenhuis, Tilburg, The Netherlands. radiol@eztilburg.nl
authors.forename: W J
authors.initials: WJ
authors.lastname: van Rooij
authors.forename: G J
authors.initials: GJ
authors.lastname: Keeren
authors.forename: J P P
authors.initials: JP
authors.lastname: Peluso
authors.forename: M
authors.initials: M
authors.lastname: Sluzewski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017542:Aneurysm, Ruptured / Q000453:epidemiology; D002533:Cerebral Angiography; D002543:Cerebral Hemorrhage / Q000453:epidemiology; D002648:Child; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D012008:Recurrence; D016896:Treatment Outcome; D055815:Young Adult