title: Analytically derived weighting factors for transmission tomography cone beam projections.
abstract: Weighting factors, which define the contributions of individual voxels of a 3D object to individual projection elements (pixels) on the detector, are the basic elements required in iterative tomographic reconstructions from transmission projections. Exact or as accurate as possible values for weighting factors are required in high-resolution reconstructions. Geometric complexity of the problem, however, makes it difficult to obtain exact weighting factor values. In this work, we derive an analytical expression for the weighting factors in cone beam projection geometry. The resulting formula is validated and applied to reconstruction from mega and kilovoltage x-ray cone beam projections. The reconstruction speed and accuracy are significantly improved by using the weighting factor values.
authors.affiliation: Department of Medical Physics, Sudbury Regional Hospital, 41 Ramsey Lake Road, Sudbury, Ontario, P3E 5J1, Canada. wyao@hrsrh.on.ca
authors.forename: Weiguang
authors.initials: W
authors.lastname: Yao
authors.forename: Konrad
authors.initials: K
authors.lastname: Leszczynski
mesh_terms: D000465:Algorithms; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity