title: The personality trait openness is related to cerebral 5-HTT levels.
abstract: Potentiation of serotonergic transmission increases cognitive flexibility, but can in other circumstances increase sensitivity to stressful environmental cues. The personality trait Openness to Experience reflects and is also associated with an increased risk for mood disorders. We hypothesized that the personality trait has an association with a biomarker of serotonergic transmission, the plasma membrane serotonin transporter (5-HTT). In 50 healthy volunteers, we tested for correlations between scores on the NEO-PI-R scale Openness to Experience and its subscales, and cerebral binding of the 5-HTT selective PET radioligand [11C]DASB. Subjects were genotyped for the 5-HTT long/short polymorphism, and for a single nucleotide polymorphism in the long allele, designated LA/LG. Midbrain [11C]DASB binding correlated negatively with scores for Openness to Experience and its two subscales, Openness to Actions and Openness to Values. The latter subscore was negatively correlated with [11C]DASB binding in all brain regions in which [11C]DASB binding was quantified. Genetic analysis showed that homozygote LA carriers had significantly higher [11C]DASB binding in the caudate nucleus, but no significant differences in openness scores. Thus, high scores in personality facets indicative of cognitive flexibility and openness to change are associated with lower [11C]DASB binding. Lower abundance of 5-HTT sites may result in potentiation of serotonergic signaling, which occurs during treatment with SSRIs. We speculate that the set-point of serotonergic signaling in an individual represents a trade-off between flexibility and vulnerability when exposed to environmental stress.
authors.affiliation: Neurobiology Research Unit, Copenhagen University Hospital Rigshospitalet, Denmark. jan@kalbitzer.net
authors.forename: Jan
authors.initials: J
authors.lastname: Kalbitzer
authors.forename: Vibe G
authors.initials: VG
authors.lastname: Frokjaer
authors.forename: David
authors.initials: D
authors.lastname: Erritzoe
authors.forename: Claus
authors.initials: C
authors.lastname: Svarer
authors.forename: Paul
authors.initials: P
authors.lastname: Cumming
authors.forename: Finn A
authors.initials: FA
authors.lastname: Nielsen
authors.forename: Sayed H
authors.initials: SH
authors.lastname: Hashemi
authors.forename: William F C
authors.initials: WF
authors.lastname: Baaré
authors.forename: Jacob
authors.initials: J
authors.lastname: Madsen
authors.forename: Steen G
authors.initials: SG
authors.lastname: Hasselbalch
authors.forename: Morten L
authors.initials: ML
authors.lastname: Kringelbach
authors.forename: Erik L
authors.initials: EL
authors.lastname: Mortensen
authors.forename: Gitte M
authors.initials: GM
authors.lastname: Knudsen
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism*; D005120:Extraversion, Psychological; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010551:Personality / Q000502:physiology*; D049268:Positron-Emission Tomography / Q000379:methods*; D012650:Self Disclosure; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013223:Statistics as Topic; D014018:Tissue Distribution
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins