Impact of HLA on the underlying primary diseases in Turkish patients with end-stage renal disease.
The number of patients with end stage renal disease (ESRD) is increasing faster than the number of renal transplantations performed per year worldwide. Of the primary diseases leading to ESRD, diabetic nephropathy is the leading cause. The purpose of the present study is to investigate the association of HLA with the primary diseases leading to ESRD in Turkish patients. A total of 3230 individuals comprising 587 ESRD patients and 2643 healthy controls were enrolled into the study. Class I HLA-A, -B typing was performed by CDC method, while class II HLA-DRB1 typing was performed by low resolution PCR-SSP. We found a significant negative association between almost all A locus antigens and primary disease groups classified as chronic glomerulonephritis and hypertensive nephrosclerosis (p < 0.05). HLA-B58 and HLA-DRB1*03 significantly correlated with amyloidosis and diabetic nephropathy, respectively. Determination of HLAs as risk factors for primary diseases leading to ESRD might be beneficial in preventing progression to ESRD and recurrence of the primary disease post-transplantation.
Karahan
Gonca Emel
GE
Department of Medical Biology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. gonca.karahan@gmail.com
Seyhun
Yalcin
Y
Oguz
Fatma Savran
FS
Kekik
Cigdem
C
Onal
Ayse Emel
AE
Yazici
Halil
H
Turkmen
Aydin
A
Aydin
Ali Emin
AE
Sever
Mehmet Sukru
MS
Eldegez
Ulug
U
Carin
Mahmut Nezih
MN
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology* / Q000235:genetics* / Q000601:surgery; D016030:Kidney Transplantation / Q000706:statistics & numerical data; D015810:Linkage Disequilibrium; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014421:Turkey; D014850:Waiting Lists; D055815:Young Adult
D006680:HLA Antigens