title: RNAither, an automated pipeline for the statistical analysis of high-throughput RNAi screens.
abstract: CONCLUSIONS
  We present RNAither, a package for the free statistical environment R which performs an analysis of high-throughput RNA interference (RNAi) knock-down experiments, generating lists of relevant genes and pathways out of raw experimental data. The library provides a quality assessment of the signal intensities, as well as a broad range of options for data normalization, different statistical tests for the identification of significant siRNAs, and a significance analysis of the biological processes involving corresponding genes. The results of the analysis are presented as a set of HTML pages. Additionally, all values and plots are available as either text files or pdf and png files.
  
  
  BACKGROUND
  http://bioconductor.org/
authors.affiliation: Viroquant Research Group Modeling, University of Heidelberg, Bioquant BQ26, Im Neuenheimer Feld 267, 69120 Heidelberg, Germany. RNAither@gmx.de
authors.forename: Nora
authors.initials: N
authors.lastname: Rieber
authors.forename: Bettina
authors.initials: B
authors.lastname: Knapp
authors.forename: Roland
authors.initials: R
authors.lastname: Eils
authors.forename: Lars
authors.initials: L
authors.lastname: Kaderali
mesh_terms: D019295:Computational Biology / Q000379:methods; D003627:Data Interpretation, Statistical; D020869:Gene Expression Profiling / Q000379:methods; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000737:chemistry; D012984:Software
chemical_list: D034741:RNA, Small Interfering