title: Osteosarcoma in adolescents and adults: survival analysis with and without lung metastases.
abstract: BACKGROUND
  Survival data are still limited and controversial about adult patients with osteosarcoma as older group of patients has mostly been excluded from the historical trials.
  
  
  METHODS
  Patients with osteosarcoma, from 1986 to 2003, in a single center, were reviewed. Survival according to a cutoff age of 40 was studied. Patients with lung metastases were identified. Variables at first lung involvement including time to first lung metastases, multiplicity and size of the metastatic lesions and use of chemotherapy were all analyzed.
  
  
  RESULTS
  A total of 247 patients, with age range of 14-77 years, were reviewed. Five-year survival is 66% with no difference between patients <40 or >or=40 years. Eighty-five patients, with either synchronous or metachronous lung involvement, have 3-year postlung metastases survival (PLMS) of 30%. Forty-seven patients (55.3%) underwent lung resection with 3-year PLMS of 38% compared with 16% for nonoperated patients (P = 0.00023). Patients who developed lung metastases within a year and have fewer than four lung lesions have better PLMS (P < 0.0001 for both).
  
  
  CONCLUSIONS
  Older patients have identical survival to pediatric population and should have a similar management approach. Complete metastectomy is the key issue for prolonged survival. Time to lung metastases and number of lung lesions are the most important prognostic factors.
authors.affiliation: Department of Medical Oncology, King Faisal Cancer Center, Riyadh, Saudi Arabia. ajubran@kfshrc.edu.sa
authors.forename: A H
authors.initials: AH
authors.lastname: Aljubran
authors.forename: A
authors.initials: A
authors.lastname: Griffin
authors.forename: M
authors.initials: M
authors.lastname: Pintilie
authors.forename: M
authors.initials: M
authors.lastname: Blackstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D016019:Survival Analysis; D055815:Young Adult