title: Treatment-refractory schizoaffective disorder in a patient with dyke-davidoff-masson syndrome.
abstract: Dyke-Davidoff-Masson syndrome, or cerebral hemiatrophy, is a pre- or perinatally acquired entity characterized by predominantly neurologic symptoms, such as seizures, facial asymmetry, contralateral hemiplegia, and mental retardation. Psychiatric symptoms are rarely reported. We report the first case of left cerebral hemiatrophy and a late onset of treatment-resistant schizoaffective disorder after a stressful life event. The patient finally responded well to clozapine. The clinical history and results from structural neuroimaging are highlighted to discuss the possible developmental bias for psychotic disorders.
authors.affiliation: Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain. benedikt.amann@med.uni-muenchen.de
authors.forename: Benedikt
authors.initials: B
authors.lastname: Amann
authors.forename: Celia
authors.initials: C
authors.lastname: García de la Iglesia
authors.forename: Peter
authors.initials: P
authors.lastname: McKenna
authors.forename: Edith
authors.initials: E
authors.lastname: Pomarol-Clotet
authors.forename: Marisa
authors.initials: M
authors.lastname: Sanchez-Guerra
authors.forename: Michael
authors.initials: M
authors.lastname: Orth
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D003024:Clozapine / Q000627:therapeutic use*; D005146:Facial Asymmetry / Q000473:pathology / Q000503:physiopathology; D006429:Hemiplegia / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine