title: Prospective study on the safety and efficacy of combined conjunctival rotational autograft with intraoperative 0.02% mitomycin C in primary pterygium excision.
abstract: OBJECTIVE
  To describe the novel use of combined conjunctival rotational autograft (CRA) and intraoperative 0.02% mitomycin C (MMC) in the treatment of primary pterygium and to evaluate its safety and efficacy.
  
  
  METHODS
  Prospective interventional case series comparing with historical controls was conducted. Patients with primary pterygium underwent pterygium excision, MMC was applied to the scleral bed after the surface conjunctiva was harvested, and the CRA was sutured back with a 180-degree rotation. Patients were followed for a minimum of 1 year.
  
  
  RESULTS
  Sixty-seven eyes from 67 patients participated in the study, of which 31 (46.3%) were men and 36 (53.7%) were women. The mean age was 58 +/- 10.6 years, (range 36-79 years). There were 2 recurrences (3%), one occurring at month 3 and the other at month 9. Compared with historical controls, CRA-MMC resulted in significantly fewer recurrences than MMC alone (P = 0.005) when adjusted for age and was equally effective when compared with limbal-conjunctival autografts. The main postoperative problem was graft injection, which was noted in 41 eyes (61%) at 1 year.
  
  
  CONCLUSIONS
  To the best of our knowledge, this was the first study on the combined use of CRA and MMC in the treatment of primary pterygium. CRA with MMC was found to be effective in the prevention of recurrence. Although injection remained as a cosmetic concern, it was a safe alternative to limbal-conjunctival autograft in cases where mobilizing autologous conjunctival tissue would not be feasible.
authors.affiliation: Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. youngla@ha.org.hk
authors.forename: Alvin L
authors.initials: AL
authors.lastname: Young
authors.forename: Patrick M K
authors.initials: PM
authors.lastname: Tam
authors.forename: Gloria Y S
authors.initials: GY
authors.lastname: Leung
authors.forename: Lulu L
authors.initials: LL
authors.lastname: Cheng
authors.forename: Philip T H
authors.initials: PT
authors.lastname: Lam
authors.forename: Dennis S C
authors.initials: DS
authors.lastname: Lam
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000008:administration & dosage* / Q000009:adverse effects; D003228:Conjunctiva / Q000637:transplantation*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage* / Q000009:adverse effects; D011183:Postoperative Complications; D011446:Prospective Studies; D011625:Pterygium / Q000188:drug therapy* / Q000601:surgery*; D012590:Sclera; D055502:Secondary Prevention; D013997:Time Factors; D014182:Transplantation, Autologous / Q000009:adverse effects; D016896:Treatment Outcome
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin