Viral and cellular messenger RNA targets of viral microRNAs.
Given the propensity of viruses to co-opt cellular pathways and activities for their benefit, it is perhaps not surprising that several viruses have now been shown to reshape the cellular environment by reprogramming the host's RNA-interference machinery. In particular, microRNAs are produced by the various members of the herpesvirus family during both the latent stage of the viral life cycle and the lytic (or productive) stage. Emerging data suggest that viral microRNAs are particularly important for regulating the transition from latent to lytic replication and for attenuating antiviral immune responses.
Cullen
Bryan R
BR
Department of Molecular Genetics & Microbiology, Center for Virology, Duke University Medical Center, Durham, North Carolina 27710, USA. culle002@mc.duke.edu
D006564:Herpesviridae / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism; D013379:Substrate Specificity
D035683:MicroRNAs; D012333:RNA, Messenger; D012367:RNA, Viral