title: Changes in circulating cytokine levels in midlife women with psychological symptoms with selective serotonin reuptake inhibitor and Japanese traditional medicine.
abstract: OBJECTIVE
  The aim of the present study was to compare the effects on serum cytokine concentrations of paroxetine, a selective serotonin re-uptake inhibitor, and kamishoyosan, a Japanese traditional medicine, in midlife women with psychological symptoms.
  
  
  METHODS
  Seventy-six women with psychological symptoms such as anxiety and mild depression as menopausal symptoms were enrolled in this study. Thirty-eight women received oral administration of 10mg paroxetine every day, and 38 women received oral administration of kamshoyosan every day for 6 months. Overall climacteric symptoms were assessed using Greene's climacteric scale. Serum levels of cytokines were measured using a multiplexed human cytokine assay.
  
  
  RESULTS
  Greene's total scores in both women treated with paroxetine and in women treated with kamishoyosan decreased significantly. Percentage decreases in Greene's total, psychological and vasomotor scores during the 6-month period in the paroxetine group were significantly greater than those in the kamishoyosan group. Serum IL-6 concentration in women treated with paroxetine decreased significantly. Serum concentrations of IL-8, IL-10, macrophage inflammatory protein (MIP)-1beta and monocyte chemoattractant protein-1 in women treated with paroxetine decreased significantly. On the other hand, serum IL-6 concentration in women treated with kamishoyosan decreased significantly, but other serum concentrations did not change significantly.
  
  
  CONCLUSIONS
  Decrease in IL-6 concentration may be involved in the mechanism of the actions of both paroxetine and kamishoyosan in women with psychological symptoms, and IL-6 may therefore be useful as a marker of treatment. The action of paroxetine may also be associated with decreases in IL-8, IL-10, MIP-1beta.
authors.affiliation: Department of Obstetrics and Gynecology, Course of Human Development, Human Development and Health Science, The University of Tokushima Graduate School, 3-18-15 Kuramoto, Tokushima 770-8503, Japan. yasui@clin.med.tokushima-u.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Yasui
authors.forename: Masayo
authors.initials: M
authors.lastname: Yamada
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Uemura
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsuchiya
authors.forename: Masamichi
authors.initials: M
authors.lastname: Noguchi
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Yuzurihara
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kase
authors.forename: Minoru
authors.initials: M
authors.lastname: Irahara
mesh_terms: D000284:Administration, Oral; D002979:Climacteric / Q000523:psychology; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000627:therapeutic use*; D019584:Hot Flashes; D006801:Humans; D019684:Magnoliopsida; D008518:Medicine, East Asian Traditional; D008875:Middle Aged; D017374:Paroxetine / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*
chemical_list: D016207:Cytokines; D004365:Drugs, Chinese Herbal; D017374:Paroxetine; D010936:Plant Extracts; D017367:Selective Serotonin Reuptake Inhibitors; C103354:kamisyoyo san