Granulomatous slack skin presenting as acquired ichthyosis and muscle masses.
We describe a case of granulomatous slack skin in a 31-year-old woman with an unusual presentation of acquired ichthyosis and muscular masses involving four limbs over 3 years. Vesicles and ulcerative skin nodules first appeared only 3 months prior to diagnosis. The diagnosis was confirmed after sequential biopsies of muscle, skin lesions, and lymph nodes, together with molecular genetic studies. The patient responded poorly to various therapies, including thalidomide, and died of doxorubicin-related cardiomyopathy.
Hsiao
Pa-Fan
PF
Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan.
Hsiao
Cheng-Hsiang
CH
Tsai
Tsen-Fang
TF
Yao
Ming
M
Jee
Shiou-Hwa
SH
D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D016410:Lymphoma, T-Cell, Cutaneous / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D009135:Muscular Diseases / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy