title: Human-to-human transmission of tuberculosis caused by Mycobacterium bovis in immunocompetent patients.
abstract: Human-to-human transmission of Mycobacterium bovis in two immunocompetent patients from the same family was confirmed by spoligotyping (pattern F35, which was only observed in cattle from the same area in France). A single allelic difference between animal and human isolates was observed with mycobacterial interspersed repetitive units containing variable-number tandem repeats, suggesting a jump across the species barrier.
authors.affiliation: CHRU de Tours, Service de Médecine Interne et Maladies Infectieuses, Tours, France. simsunder@hotmail.fr
authors.forename: S
authors.initials: S
authors.lastname: Sunder
authors.forename: P
authors.initials: P
authors.lastname: Lanotte
authors.forename: S
authors.initials: S
authors.lastname: Godreuil
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: M L
authors.initials: ML
authors.lastname: Boschiroli
authors.forename: J M
authors.initials: JM
authors.lastname: Besnier
mesh_terms: D000328:Adult; D000818:Animals; D015373:Bacterial Typing Techniques; D002417:Cattle; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics; D005192:Family Health; D005260:Female; D005602:France; D005838:Genotype; D006801:Humans; D020071:Interspersed Repetitive Sequences; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats; D009163:Mycobacterium bovis / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D014376:Tuberculosis / Q000382:microbiology* / Q000635:transmission*; D055815:Young Adult
chemical_list: D004269:DNA, Bacterial