[Effect of capsule of Shenshuai Yangzhen on malnutrition rats with chronic renal failure by 5/6 nephrectomy].
OBJECTIVE
To investigate the effects of capsule of Shenshuai Yangzhen, a preparation of traditional Chinese medicine, on malnutrition rats with chronic renal failure (CRF).


METHODS
SD rats received 5/6 nephrectomy for preparation of CRF models, and fed 4% casein at the same time. Observed when malnutrition began. Those consistents with malnutrition of CRF condition were randomized into model control group, Ketosteril group, Shenshuai Yangzhen group, and normal control group. After 4-weeks treatment as indicated, The blood parameters, like blood serum albumin (ALB), type-1 insulin like growth factor (IGF-1), total cholesterol (TC), triglyeride (TG), urea nitrogen (BUN), serum creatinine (Scr), haemoglobin (Hb), 24 hour urineprotein (24hUpr) and weight were determined. Nephrotic tissue was observed by microscope (included HE and PAS).


RESULTS
Malnutrition situation in CRF rats began at the end of 10-weeks. After 4-weeks treatment, weight in Shenshuai Yangzhen group were higher significantly (P < 0.05). Compared with model control group, blood serum BUN (P < 0.05), SCr (P < 0. 05) and 24h Upr (P < 0.001) in Shenshuai Yangzhen group were significantly lower with substantially elevated blood serum ALB, Hb, IGF-1 (P < 0.01; P < 0.001; P < 0.001, respectively). Pathology of Shenshuai Yangzhen group was a meliorated significantly after treated.


CONCLUSIONS
Capsule of Shenshuai Yangzhen has a possible therapic effect on improving malnutrition in rats with renal insufficiency.
Wei
Lian-Bo
LB
Department of Nephoropathy of Western and Chinese Medicine, Zhujiang Hospital, Southern Medical University/Emphasis subject of Nephropathy of State Administration of Traditional Chinese Medicine, Guangzhou 510282, China. weilianbo@163.com
Deng
Cong
C
Chen
Jie-Bin
JB
Li
Yu-Ming
YM
Huang
Li-Wen
LW
Gong
Chun-Shui
CS
D000818:Animals; D001806:Blood Urea Nitrogen; D002214:Capsules; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D006454:Hemoglobins / Q000032:analysis; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D044342:Malnutrition / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D009392:Nephrectomy; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012709:Serum Albumin / Q000032:analysis; D014280:Triglycerides / Q000097:blood
D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D006454:Hemoglobins; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol; D003404:Creatinine