title: Predicting respiratory instability in the ICU.
abstract: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) contribute to the morbidity and mortality of intensive care patients worldwide, and have large associated human and financial costs. We identified a reference data set of 624 mechanically-ventilated patients in the MIMIC-II intensive care database with and without low PaO(2)/FiO(2) ratios (termed respiratory instability), and developed prediction algorithms for distinguishing these patients prior to the critical event. In the end, we had four rule sets using mean airway pressure, plateau pressure, total respiratory rate and oxygen saturation (SpO(2)), where the specificity/sensitivity rates were either 80%/60% or 90%/50%.
authors.affiliation: Philips Research North America, Briarcliff Manor, NY, USA. colleen.ennett@philips.com
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Ennett
authors.forename: K P
authors.initials: KP
authors.lastname: Lee
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Eshelman
authors.forename: Brian
authors.initials: B
authors.lastname: Gross
authors.forename: Larry
authors.initials: L
authors.lastname: Nielsen
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Frassica
authors.forename: Mohammed
authors.initials: M
authors.lastname: Saeed
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003422:Critical Care / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen; D012121:Respiration, Artificial; D012128:Respiratory Distress Syndrome / Q000382:microbiology* / Q000401:mortality / Q000628:therapy*; D012680:Sensitivity and Specificity; D045169:Severe Acute Respiratory Syndrome / Q000150:complications* / Q000276:immunology / Q000401:mortality* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D010100:Oxygen