title: Decreased plasma concentrations of adiponectin in patients with slow coronary flow.
abstract: Adiponectin has multiple protective effects on vascular endothelium through anti-inflammatory and anti-atherogenic properties. Recent data suggested that endothelial activation and inflammation may contribute to the pathogenesis of slow coronary flow (SCF). Therefore, we investigated whether adiponectin plasma concentrations were decreased in patients with SCF compared to subjects with normal coronary flow. The study population consisted of 35 patients with angiographically documented SCF in all three coronary arteries and 35 sex- and age-matched cases with normal coronary flow. Coronary flow rates of all participants were determined by Thrombolysis in Myocardial Infarction (TIMI) frame count. Plasma adiponectin concentrations were measured by an enzyme-linked immunosorbent assay method using commercially available adiponectin kits. There were no statistically significant differences between the patients with SCF and the subjects with normal coronary flow in terms of demographic characteristics and cardiovascular risk factors (P>0.05). Plasma adiponectin concentrations of patients with SCF were found to be significantly lower than those with normal coronary flow (4.77+/-3.86 mg/ml vs 10.8+/-6.60 mg/ml, P=0.001, respectively). Plasma adiponectin levels were correlated significantly and inversely with mean TIMI frame count in patients with SCF (r= -0.441, P=0.008). Furthermore, the Receiver Operator Characteristics curve of adiponectin concentrations showed that an adiponectin <4.6 mg/ml is associated with SCF with a sensitivity of 68.6%, specificity of 82.9%, positive predictive value of 80.0%, and negative predictive value of 72.5%. Our findings suggest that endothelial inflammation may play a role in the pathogenesis of SCF phenomenon.
authors.affiliation: Department of Cardiology, Turkiye Yuksek Ihtisas Hospital, Ankara, Turkey. haticsel@hotmail.com
authors.forename: Hatice
authors.initials: H
authors.lastname: Selcuk
authors.forename: Mehmet Timur
authors.initials: MT
authors.lastname: Selcuk
authors.forename: Ahmet
authors.initials: A
authors.lastname: Temizhan
authors.forename: Orhan
authors.initials: O
authors.lastname: Maden
authors.forename: Gul Sevim
authors.initials: GS
authors.lastname: Saydam
authors.forename: Hakan
authors.initials: H
authors.lastname: Ulupinar
authors.forename: Mehmet
authors.initials: M
authors.lastname: Dogan
authors.forename: Cengiz
authors.initials: C
authors.lastname: Aydin
authors.forename: Deniz I
authors.initials: DI
authors.lastname: Topcu
authors.forename: Ali
authors.initials: A
authors.lastname: Sasmaz
mesh_terms: D052242:Adiponectin / Q000097:blood*; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012039:Regional Blood Flow / Q000502:physiology*; D012720:Severity of Illness Index
chemical_list: D052242:Adiponectin