title: Prenatal alcohol exposure and language delay in 2-year-old children: the importance of dose and timing on risk.
abstract: OBJECTIVE
  The aim of this study was to investigate the association of dose and timing of prenatal alcohol exposure with early language acquisition.
  
  
  METHODS
  We examined language delay in a randomly selected, population-based sample of Western Australian children born in 1995-1996 whose mothers had agreed to participate in a longitudinal study on health-related behaviors and who had completed the 2-year questionnaire (N = 1739). Information on alcohol consumption was collected at 3 months after birth for four periods; the three months pre-pregnancy and for each trimester separately. Prenatal alcohol exposure was grouped into none, low, moderate-heavy and binge (>5) based on the total quantity consumed per week, quantity consumed per occasion, and frequency of consumption. The communication scale from the Ages & Stages Questionnaire was used to evaluate language delay. Logistic regression analysis was used to generate odds ratios and 95% confidence intervals, adjusted for confounding factors.
  
  
  RESULTS
  There was no association between low levels of alcohol consumption and language delay at any time period, although there was a nonsignificant 30% increase in risk when moderate-to-heavy levels of alcohol were consumed in the third trimester. Children exposed to a binge pattern of maternal alcohol consumption in the second trimester had nonsignificant, three-fold increased odds of language delay, with a similar estimate following third trimester alcohol exposure after controlling for covariates.
  
  
  CONCLUSIONS
  This study did not detect an association between low levels of prenatal alcohol exposure and language delay when compared with women who abstained from alcohol during pregnancy. A nonsignificant threefold increase in the likelihood of language delay was seen in children whose mothers binged during late pregnancy. However, the small numbers of women with a binge-drinking pattern in late pregnancy limited the power of this study; studies analyzing larger numbers of children exposed to binge drinking in late pregnancy are needed.
authors.affiliation: Division of Population Sciences, Telethon Institute for Child Health Research, PO Box 855, West Perth, WA 6872, Australia. colleeno@ichr.uwa.edu.au
authors.forename: Colleen
authors.initials: C
authors.lastname: O'Leary
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Zubrick
authors.forename: Catherine L
authors.initials: CL
authors.lastname: Taylor
authors.forename: Glenys
authors.initials: G
authors.lastname: Dixon
authors.forename: Carol
authors.initials: C
authors.lastname: Bower
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007805:Language Development Disorders / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology*; D012307:Risk Factors