Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol.
GRAPES FOR AMYLOIDS: The red wine compound resveratrol can effectively inhibit the formation of IAPP amyloid that is found in type II diabetes. Our in vitro inhibition results do not depend on the antioxidant activity of resveratrol. Further, the markedly enhanced cell survival in the presence of resveratrol also indicates that the small oligomeric structures that are observed during beta-sheet formation are not toxic and could be off-pathway assembly products.
Mishra
Rajesh
R
Faculty of Chemistry, Physical Chemistry I, Biophysical Chemistry, TU Dortmund, Dortmund, Germany.
Sellin
Daniel
D
Radovan
Diana
D
Gohlke
Andrea
A
Winter
Roland
R
D000682:Amyloid / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry*; D002460:Cell Line; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D015394:Molecular Structure; D011487:Protein Conformation; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry*; D014920:Wine
D000682:Amyloid; D000975:Antioxidants; D058228:Islet Amyloid Polypeptide; D013267:Stilbenes; D000077185:Resveratrol