title: Evaluation of systolic properties in hypertensive patients with different degrees of diastolic dysfunction and normal ejection fraction.
abstract: BACKGROUND
  Left ventricular (LV) diastolic dysfunction (DD) associated with a preserved ejection fraction (EF) is a frequent alteration in hypertensive patients, usually considered an impairment of the diastolic phase alone. However, because systole and diastole are strictly correlated to one another, it is possible that hypertensive patients with isolated DD may also present with initial abnormalities of LV systolic properties, particularly those presenting with a more severe degree of DD. We performed a multiparametric echocardiographic assessment of LV systolic properties in patients without cardiovascular diseases, with preserved EF and different degrees of DD.
  
  
  METHODS
  We evaluated 1,073 hypertensive subjects showing EF >55% and no overt heart disease.
  
  
  RESULTS
  A total of 362 patients had normal diastolic function (N), 609 displayed delayed relaxation pattern (DR), and 102 presented a pseudonormal filling pattern (PN). Albeit most of the subjects with DD (DR, PN) had systolic indexes within normal range, they presented a significant reduction of index stroke volume (SV) (P < 0.0001) and stroke work (SW) (P < 0.0001), EF (P < 0.01), midwall shortening (MFS) (P < 0.0001), circumferential end-systolic stress-corrected MFS (cESS-MFS) (P < 0.001), and tissue Doppler (TD) systolic velocity (P < 0.0001) as compared to the N group, particularly the PN group.After adjustments, the reductions of LV systolic indexes were still significantly related to DD, particularly to PN.
  
  
  CONCLUSIONS
  Our results suggest a relation between LV systolic and diastolic properties in patients with normal EF. They also highlight the early onset of a preclinical reduction of systolic properties in patients with "isolated" DD, which is related to the degree of dysfunction.
authors.affiliation: Cardiology Department, II School of Medicine, University of Rome La Sapienza, S. Andrea Hospital, Rome, Italy.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Sciarretta
authors.forename: Francesco
authors.initials: F
authors.lastname: Paneni
authors.forename: Giuseppino M
authors.initials: GM
authors.lastname: Ciavarella
authors.forename: Luciano
authors.initials: L
authors.lastname: De Biase
authors.forename: Francesca
authors.initials: F
authors.lastname: Palano
authors.forename: Rossella
authors.initials: R
authors.lastname: Baldini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Quarta
authors.forename: Giuliano
authors.initials: G
authors.lastname: Tocci
authors.forename: Umberto
authors.initials: U
authors.lastname: Benedetto
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferrucci
authors.forename: Speranza
authors.initials: S
authors.lastname: Rubattu
authors.forename: Giovanni
authors.initials: G
authors.lastname: de Simone
authors.forename: Massimo
authors.initials: M
authors.lastname: Volpe
mesh_terms: D000328:Adult; D000368:Aged; D003971:Diastole; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D012189:Retrospective Studies; D013318:Stroke Volume; D013599:Systole