title: Hemodynamic alterations and wall properties in large arteries of young, normotensive, and non-obese women with polycystic ovary syndrome.
abstract: Young, normotensive, and non-obese women with polycystic ovary syndrome (PCOS) may present abnormal hemodynamic alterations (HA). The purpose of this study was to investigate heart rate (HR), intima-media thickness (IMT), and diameter (DCCA) in the common carotid arteries (CCA), flow velocities, and resistance index in both extracranial carotid and vertebral arteries (VA), in the abdominal aorta (AO) and in the renal arteries (RA) in PCOS women and matched controls. This was a case-control study conducted at a tertiary University Hospital. We studied 53 PCOS women and 53 healthy matched volunteers as controls. The previously reported parameters were assessed using color Doppler ultrasonography. HR, IMT in the CCA, and peak systolic velocity in all examined arteries were significantly increased in PCOS women compared to controls. On the contrary, DCCA was significantly decreased in PCOS women compared to controls. End diastolic velocity (EDV) in both VA and RA, in the AO and in the left extracranial carotid system was significantly increased in the PCOS group compared to controls. Furthermore, the peripheral resistance (PR) of AO and right external carotid artery was also found to be increased while in both RA and in left VA, PR was decreased. No further statistical significant HA in EDV and PR were noted. The results of this study provide evidence for a mild hyperdynamic circulation in young, normotensive, non-obese women with PCOS compared to controls, indicating a mild sympathetic activation at an early age, which may be an underlying cause of hypertension and cardiovascular risk.
authors.affiliation: Third Department of Obstetrics and Gynecology, University of Athens, Attikon University Hospital Athens Greece, Rimini 1 Chaidari, Athens, Greece, PC 12461. trakakis@yahoo.gr
authors.forename: E
authors.initials: E
authors.lastname: Trakakis
authors.forename: A
authors.initials: A
authors.lastname: Balanika
authors.forename: C
authors.initials: C
authors.lastname: Baltas
authors.forename: C
authors.initials: C
authors.lastname: Loghis
authors.forename: G
authors.initials: G
authors.lastname: Simeonidis
authors.forename: V
authors.initials: V
authors.lastname: Vaggopoulos
authors.forename: O
authors.initials: O
authors.lastname: Papakonstantinou
authors.forename: A
authors.initials: A
authors.lastname: Gouliamos
authors.forename: G
authors.initials: G
authors.lastname: Salamalekis
authors.forename: D
authors.initials: D
authors.lastname: Kassanos
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D001783:Blood Flow Velocity; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology*; D017539:Tunica Intima / Q000000981:diagnostic imaging; D017540:Tunica Media / Q000000981:diagnostic imaging; D018615:Ultrasonography, Doppler, Color; D014655:Vascular Resistance; D014711:Vertebral Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*