Walking the walk: how kinesin and dynein coordinate their steps.
Molecular motors drive key biological processes such as cell division, intracellular organelle transport, and sperm propulsion and defects in motor function can give rise to various human diseases. Two dimeric microtubule-based motor proteins, kinesin-1 and cytoplasmic dynein can take over one hundred steps without detaching from the track. In this review, we discuss how these processive motors coordinate the activities of their two identical motor domains so that they can walk along microtubules.
Gennerich
Arne
A
Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158-2200, USA.
Vale
Ronald D
RD
D002468:Cell Physiological Phenomena; D004398:Dyneins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D016547:Kinesins / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D017434:Protein Structure, Tertiary
D004398:Dyneins; D016547:Kinesins