Characterization of PEDF: a multi-functional serpin family protein.
Pigment epithelium-derived factor (PEDF) is a 50 kDa secreted glycoprotein that belongs to the non-inhibitory serpin family group. PEDF has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties; it balances angiogenesis in the eye and blocks tumor progression. The mechanisms underlying most of these events are not completely clear; however, it appears that PEDF acts via multiple high affinity ligands and cell receptors. In this review article, we will summarize the current knowledge on the biochemical properties of PEDF and its receptors, the multimodal activities of PEDF and finally address the therapeutic potential of PEDF in treating angiogenesis-, neurodegeneration- and inflammation-related diseases.
Filleur
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Department of Urology, Texas Tech University Health Sciences Center, 3601 4th Street, MS 6591, Lubbock, Texas 79430-6591, USA. stephanie.filleur@ttuhsc.edu
Nelius
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de Riese
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Kennedy
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D020533:Angiogenesis Inhibitors; D005136:Eye Proteins / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D018013:Receptors, Neuropeptide / Q000378:metabolism; D015843:Serpins / Q000378:metabolism / Q000502:physiology* / Q000627:therapeutic use; D000099174:Pigment Epithelium-Derived Factor
D020533:Angiogenesis Inhibitors; D005136:Eye Proteins; D009414:Nerve Growth Factors; D018013:Receptors, Neuropeptide; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor; C400531:pigment epithelium-derived factor receptor