Tropical theileriosis: cytotoxic T lymphocyte response to vaccination.
Cattle which survive an infection with Theileria annulata become effectively immune to challenge with the same parasite strain, and are thought to be protected against a heterologous strain of the parasite. T-cells play a crucial role in both induction and maintenance of immunity to T. annulata. The generation of cytotoxic T lymphocytes (CTL) is closely related to the control of the infection - macroschizont-infected cells are killed in an MHC class I restricted manner. Any strain-specificity induced by immunisation is likely to be manifested by CTL. Besides CTLs, CD4+ T-cells also play an important role in protective immunity to T. annulata infection.
Seitzer
Ulrike
U
Veterinary Infection Biology and Immunology, Research Center Borstel, Parkallee 22, 23845 Borstel, Germany. useitzer@fz-borstel.de
Ahmed
Jabbar
J
D000818:Animals; D002417:Cattle; D003602:Cytotoxicity, Immunologic; D008213:Lymphocyte Activation; D016052:Protozoan Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D016796:Theileria annulata / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D014611:Vaccination
D016052:Protozoan Vaccines