title: Association between functional FABP2 promoter haplotypes and body mass index: analyses of 8072 participants of the KORA cohort study.
abstract: Studies in relatively small cohorts provide preliminary evidence that functional fatty acid binding protein 2 (FABP2) promoter haplotypes are associated with type 2 diabetes and BMI. Here, we studied the influence of the haplotypes on BMI by using 8072 male and female participants of the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) cohort. By linear regression analysis, we found in males a reduction of -0.39 BMI units (95% CI: -0.73, -0.05, p = 0.024) in homozygous FABP2 promoter haplotype B carriers. Carriers of haplotype B showed a significant decrease in BMI of -0.19 BMI units (95% CI: -0.35, -0.02, p = 0.027). In accordance, a significant reduction in BMI of the minor haplotype carriers in the BMI point categories of 25-30 (BMI units: -0.10, 95% CI: -0.18, -0.01, p = 0.03) and < 30 (BMI units: -0.37, 95% CI: -0.67, -0.07, p = 0.02) were found. In summary, the minor FABP2 promoter haplotype B contributes to a reduced BMI in men. This provides evidence that functional FABP2 contributes to multifactorialy regulated body weight.
authors.affiliation: Institute of Human Nutrition and Food Science, Molecular Nutrition, Christian-Albrecht-University, Kiel, Germany.
authors.forename: Mike
authors.initials: M
authors.lastname: Böhme
authors.forename: Harald
authors.initials: H
authors.lastname: Grallert
authors.forename: Maja
authors.initials: M
authors.lastname: Klapper
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.forename: Alexandra
authors.initials: A
authors.lastname: Fischer
authors.forename: Iris
authors.initials: I
authors.lastname: Heid
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Frank
authors.initials: F
authors.lastname: Döring
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D015331:Cohort Studies; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic
chemical_list: C493404:FABP2 protein, human; D050556:Fatty Acid-Binding Proteins