Homologous in vitro fertilization in Turner syndrome: insights from a case report.
OBJECTIVE
To describe a bigeminal pregnancy obtained with a homologous intracytoplasmic sperm injection cycle in a patient with high-grade mosaic Turner syndrome (45,XO/47,XXX 97.5%/2.5%) with bicuspid aortic valve.


METHODS
Case report.


METHODS
Unit of Pathophysiology of Human Reproduction in a general hospital.


METHODS
Patient with mosaic Turner syndrome with bicuspid aortic valve.


METHODS
Homologous intracytoplasmic sperm injection cycle after controlled ovarian hyperstimulation with a GnRH agonist flare-up depot protocol and menotropins.


METHODS
Pregnancy development, echocardiographic monitoring of aortic root, karyotypes of progeny.


RESULTS
Ongoing bigeminal pregnancy with the delivery of two healthy infants (46,XX and 46,XY, respectively) by cesarean section without any cardiovascular complication or aortic root echocardiographic modification in the mother.


CONCLUSIONS
Even in patients with Turner syndrome with high-grade 45,XO mosaicism and reduced ovarian reserve, a trial of homologous reproduction should be offered after a thorough cardiologic evaluation to avoid pregnancy-related cardiovascular complications.
Manno
Massimo
M
Maternal-Paediatric Department, Pathophysiology of Human Reproduction and Sperm Bank Unit, Pordenone Hospital, Pordenone, Italy. massimo.manno@aopn.fvg.it
Tomei
Francesco
F
Cervi
Marta
M
Gaspardo
Gianfranco
G
Antonini-Canterin
Francesco
F
Nicolosi
Gianluigi
G
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000235:genetics / Q000628:therapy*; D007621:Karyotyping; D009030:Mosaicism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics / Q000503:physiopathology; D011272:Pregnancy, Multiple; D014424:Turner Syndrome / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D014427:Twins