Genetic control of programmed cell death (apoptosis) in Drosophila.
Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.
Xu
Dongbin
D
The University of Texas MD Anderson Cancer Center, The Genes and Development Graduate Program, Department of Biochemistry and Molecular Biology, Houston, Texas 77030, USA.
Woodfield
Sarah E
SE
Lee
Tom V
TV
Fan
Yun
Y
Antonio
Christian
C
Bergmann
Andreas
A
D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D020169:Caspases / Q000235:genetics / Q000502:physiology; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D005260:Female; D017344:Genes, Insect; D008957:Models, Genetic; D009154:Mutation; D009866:Oogenesis; D015398:Signal Transduction; D054875:Ubiquitination
D029721:Drosophila Proteins; C400550:dark protein, Drosophila; D020169:Caspases