title: Systematic review of endoscopic treatments for gastro-oesophageal reflux disease.
abstract: BACKGROUND
  The aim of this review was to assess the safety and efficacy of endoscopic procedures for gastro-oesophageal reflux disease.
  
  
  METHODS
  Literature databases including Medline, Embase and PubMed were searched up to May 2006 without language restriction. Randomized controlled trials and non-randomized comparative studies with at least ten patients in each study arm, and case series studies of at least ten patients, were included.
  
  
  RESULTS
  A total of 33 studies examining seven endoscopic procedures (Stretta procedure, Bard EndoCinch, Wilson-Cook Endoscopic Suturing Device, NDO Plicator, Enteryx, Gatekeeper Reflux Repair System and Plexiglas) were included in the review. Of the three procedures that were tested against sham controls (Stretta procedure, Bard EndoCinch and Enteryx), patient outcomes in the treatment group were either as good as, or significantly better than, those of control patients in terms of heartburn symptoms, quality of life and medication usage. However, for the two procedures that were tested against laparoscopic fundoplication (Stretta) procedure and Bard EndoCinch), outcomes for patients in the endoscopic group were either as good as, or inferior to, those for the laparoscopic group.
  
  
  CONCLUSIONS
  At present there is insufficient evidence to determine the safety and efficacy of endoscopic procedures for gastro-oesophageal reflux disease, particularly in the long term.
authors.affiliation: Department of Surgery, University of Adelaide and The Queen Elizabeth Hospital, South Australia, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Chen
authors.forename: C
authors.initials: C
authors.lastname: Barber
authors.forename: P
authors.initials: P
authors.lastname: McLoughlin
authors.forename: P
authors.initials: P
authors.lastname: Thavaneswaran
authors.forename: G G
authors.initials: GG
authors.lastname: Jamieson
authors.forename: G J
authors.initials: GJ
authors.lastname: Maddern
mesh_terms: D004945:Esophagoscopy / Q000009:adverse effects / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000601:surgery / Q000628:therapy*; D005773:Gastroscopy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D013536:Suture Techniques; D016896:Treatment Outcome