Objective grading of the anterior eye.
OBJECTIVE
To convert objective image analysis of anterior ocular surfaces into recognisable clinical grades, in order to provide a more sensitive and reliable equivalent to current subjective grading methods; a prospective, randomized study correlating clinical grading with digital image assessment.


METHODS
The possible range of clinical presentations of bulbar and palpebral hyperaemia, palpebral roughness and corneal staining were represented by 4 sets of 10 images. The images were displayed in random order and graded by 50 clinicians using both subjective CCLRU and Efron grading scales. Previously validated objective image analysis was performed 3 times on each of the 40 images. Digital measures included edge-detection and relative-coloration components. Step-wise regression analysis determined correlations between the average subjective grade and the objective image analysis measures.


RESULTS
Average subjective grades could be predicted by a combination of the objective image analysis components. These digital "grades" accounted for between 69% (for Efron scale-graded palpebral redness) and 98% (for Efron scale-graded bulbar hyperaemia) of the subjective variance.


CONCLUSIONS
The results indicate that clinicians may use a combination of vessel areas and overall hue in their judgment of clinical severity for certain conditions. Objective grading can take these aspects into account, and be used to predict an average "objective grade" to be used by a clinician in describing the anterior eye. These measures are more sensitive and reliable than subjective grading while still utilizing familiar terminology, and can be applied in research or practice to improve the detection, and monitoring of ocular surface changes.
Peterson
Rachael C
RC
Centre for Contact Lens Research, University of Waterloo, Waterloo, Canada. rpeterso@uwaterloo.ca
Wolffsohn
James S
JS
D003316:Corneal Diseases / Q000473:pathology; D005128:Eye Diseases / Q000473:pathology*; D019793:Fluorescein; D005456:Fluorescent Dyes; D006801:Humans; D006940:Hyperemia / Q000473:pathology*; D007091:Image Processing, Computer-Assisted; D008954:Models, Biological; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index
D005456:Fluorescent Dyes; D019793:Fluorescein