title: Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.
abstract: Synthesis and SAR of para-alkylthiophenoxyacetic acids is described. Achiral compounds 30, 31 and 32 were identified as potent and selective PPARdelta agonists.
authors.affiliation: Drug Discovery, Johnson and Johnson Pharmaceutical Research and Development, LLC, 8 Clarke Drive, Cranbury, NJ 08512, USA. rzhang4@prdus.jnj.com
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
authors.forename: Alan
authors.initials: A
authors.lastname: Deangelis
authors.forename: Aihua
authors.initials: A
authors.lastname: Wang
authors.forename: Ellen
authors.initials: E
authors.lastname: Sieber-McMaster
authors.forename: Xun
authors.initials: X
authors.lastname: Li
authors.forename: Ronald
authors.initials: R
authors.lastname: Russell
authors.forename: Patricia
authors.initials: P
authors.lastname: Pelton
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
authors.forename: Peifang
authors.initials: P
authors.lastname: Zhu
authors.forename: Lubing
authors.initials: L
authors.lastname: Zhou
authors.forename: Keith
authors.initials: K
authors.lastname: Demarest
authors.forename: William V
authors.initials: WV
authors.lastname: Murray
authors.forename: Gee-Hong
authors.initials: GH
authors.lastname: Kuo
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D006016:Glycolates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D047494:PPAR delta / Q000819:agonists*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000494:pharmacology
chemical_list: C425931:GW 501516; D006016:Glycolates; D047494:PPAR delta; D013844:Thiazoles; C005446:thiophenoxyacetic acid