Pertussis vaccine: a critique.
A critical level of serum IgG pertussis toxin antibody is both essential and sufficient to confer individual and herd immunity to pertussis. Monocomponent pertussis toxoid conferred such immunity in Sweden and in Denmark. We refute the notion that filamentous hemagglutinin, pertactin, and fimbriae add to the immunity conferred by pertussis toxoid and describe the artifact created when efficacy is estimated for multicomponent pertussis vaccines. Lastly, the genetically-inactivated mutant pertussis toxoid is safer, more immunogenic, and should be more effective than the current chemically-inactivated pertussis toxin.
Robbins
John B
JB
Fogarty International Center, National Institute of Health, Bethesda, MD 20892-2423, USA. robbinsJo@mail.nih.gov
Schneerson
Rachel
R
Keith
Jerry M
JM
Miller
Mark A
MA
Kubler-Kielb
Joanna
J
Trollfors
Birger
B
D018829:Adhesins, Bacterial / Q000276:immunology; D000328:Adult; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D006801:Humans; D032521:Immunity, Herd; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D037342:Pertussis Toxin / Q000276:immunology; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D014121:Toxoids / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D010566:Virulence Factors, Bordetella / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*
D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D014121:Toxoids; D015164:Vaccines, Inactivated; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis; C051093:pertussis toxoid; C068929:pertactin; D037342:Pertussis Toxin