[The role of cysteinyl leukotrienes in chronic inflammation and neoplasia of the intestine].
It has recently been demonstrated that cysteinyl leukotrienes are involved in a variety of proinflammatory and neoplastic functions. This article gives an up-to-date overview of the present knowledge of these bioactive lipid molecules. Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are applied as models of their cellular actions. It is described how signalling cascades initiated by cysteinyl leukotrienes represent alternative ways in which IBD might progress and lead to the development and propagation of CRC, and as such represent potential targets for future therapeutic regimens to manage chronic inflammatory disorders and cancer.
Broom
Oliver Jay
OJ
Gastroenheden, Medicinsk Sektion, Forskningslaboratoriet 54 03, Herlev Hospital, DK-2730 Herlev. oliver.broom@gmail.com
Nielsen
Ole Haagen
OH
D002462:Cell Membrane / Q000378:metabolism; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D017998:Leukotriene D4 / Q000378:metabolism; D015289:Leukotrienes / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D018077:Receptors, Leukotriene / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction
D018836:Inflammation Mediators; D015289:Leukotrienes; D018077:Receptors, Leukotriene; D017998:Leukotriene D4