IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
BACKGROUND
Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.


METHODS
We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.


RESULTS
Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples.


CONCLUSIONS
Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.
Einarsdottir
Elisabet
E
Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. elisabet.einarsdottir@helsinki.fi
Koskinen
Lotta L E
LL
Dukes
Emma
E
Kainu
Kati
K
Suomela
Sari
S
Lappalainen
Maarit
M
Ziberna
Fabiana
F
Korponay-Szabo
Ilma R
IR
Kurppa
Kalle
K
Kaukinen
Katri
K
Adány
Róza
R
Pocsai
Zsuzsa
Z
Széles
György
G
Färkkilä
Martti
M
Turunen
Ulla
U
Halme
Leena
L
Paavola-Sakki
Paulina
P
Not
Tarcisio
T
Vatta
Serena
S
Ventura
Alessandro
A
Löfberg
Robert
R
Torkvist
Leif
L
Bresso
Francesca
F
Halfvarson
Jonas
J
Mäki
Markku
M
Kontula
Kimmo
K
Saarialho-Kere
Ulpu
U
Kere
Juha
J
D'Amato
Mauro
M
Saavalainen
Päivi
P
D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics*; D003424:Crohn Disease / Q000150:complications / Q000235:genetics*; D005387:Finland; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006814:Hungary; D007558:Italy; D015810:Linkage Disequilibrium; D011565:Psoriasis / Q000150:complications / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D013548:Sweden
D005819:Genetic Markers; C515500:IL23R protein, human; D018123:Receptors, Interleukin