title: [Study on preparation technology of aconitine liposomes].
abstract: OBJECTIVE
  To optimize the prescription and preparation of aconitine liposomes.
  
  
  METHODS
  Aconitine liposomes were prepared by ethanol injection method. The encapsulation efficiency was taken as inspection target and the preparation of liposomes were optimized by orthogonal design. HPLC was used to measure the encapsulation efficiency.
  
  
  RESULTS
  The best prescription was aconitine/ lecithin/cholesterol( 1: 15: 5)with phosphate buffer solution (pH 7. 4) as hydration media. The hydration temperature was 60 degrees C.
  
  
  CONCLUSIONS
  The optimized formulation of aconitine liposomes is reasonable in prescription, practicable in technology, high in encapsulation efficiency and good in stability.
authors.affiliation: College of Chemical Engineering, Wuhan University of Technology, Wuhan 430070, China.
authors.forename: Wen-Wen
authors.initials: WW
authors.lastname: Dong
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Zhang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Liu
authors.forename: Dan-Qing
authors.initials: DQ
authors.lastname: Geng
mesh_terms: D000157:Aconitine / Q000737:chemistry*; D031841:Aconitum / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002784:Cholesterol / Q000737:chemistry; D004355:Drug Stability; D000431:Ethanol; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D010710:Phosphates / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D008081:Liposomes; D010710:Phosphates; D010713:Phosphatidylcholines; D000431:Ethanol; D002784:Cholesterol; D000157:Aconitine