Molecular pathways involved in cell death after chemically induced DNA damage.
DNA damage is at the center of the genesis, progression and treatment of cancer. We review here the molecular mechanisms of the DNA damage inducing small molecules most commonly used in cancer therapy. Cell cycle control and DNA repair mechanisms are known to be activated after DNA damage. Here, we revise recent discoveries related to the cell cycle control and DNA repair processes and how these findings are being utilized for the more efficient, powerful and selective therapies for cancer treatment.
Sánchez-Olea
Roberto
R
Instituto de Física, Universidad Autónoma de San Luis Potosí, Mexico. rsanchez@ifisica.uaslp.mx
Calera
Mónica R
MR
Degterev
Alexei
A
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D016923:Cell Death / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects*
D000970:Antineoplastic Agents