[Study on the relationship between polymorphisms of XPA gene and susceptibility of esophageal cancer].
OBJECTIVE
To explore the relationships between the polymorphisms of xeroderma pigmentosum A (XPA) and the susceptibility of esophageal cancer (EC), as well as its interaction with environmental factors-gene in Changzhi area, Shanxi province.


METHODS
A case-control study was conducted, including 196 cases of EC and 201 controls. XPA 23G polymorphisms were determined with polymerase chain-restriction on fragment length polymorphism (PCR-RFLP).


RESULTS
The risk of EC was significantly degraded in the individuals who had been carrying the XPA heterozygote (A/G) and mutation genotype (G/G), compared to those with wild genotype (chi2 = 16.21, P < 0.01) and the ORs were 0.58 (0.37-0.91) and 0.32 (0.18-0.56), respectively. There was negative interaction between XPA 23G mutation genotype and the consumption of pickled food (S = 0.04, API= -0.77).


CONCLUSIONS
Genetic polymorphism in the XPA 23G might be associated with esophageal cancer in Changzhi area, and there was a negative action between XPA predisposing genotype and the consumption of pickled food.
Feng
Xiang-Xian
XX
School of Public Health, Huazhong University of Science and Technology, Wuhan 430030, China.
Duan
Pei-Fen
PF
Wang
Li-Bing
LB
Zhang
Jian-Bin
JB
Lu
Zu-Xun
ZX
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D004938:Esophageal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D051760:Xeroderma Pigmentosum Group A Protein / Q000235:genetics*
D051760:Xeroderma Pigmentosum Group A Protein