title: Two-dimensional droplet-based surface plasmon resonance imaging using electrowetting-on-dielectric microfluidics.
abstract: This article presents a multichannel droplet-based surface plasmon resonance platform. The platform comprises a digital electrowetting-on-dielectric (EWOD) microfluidic device coupled to surface plasmon resonance imaging (SPRi). SPRi is now a well-established detection technique that enables in-situ monitoring of multiple reactions occurring at the surface of the chip without the use of labels. Currently, the limiting factor in the application of SPRi for high-throughput applications is the flow-cell technology which relies on sequential sample processing within the continuous fluid flow. An original solution compared to the continuous flow-cell technology is proposed to increase the capability of existing SPRi technology. A parallel SPRi detection of different samples on the surface is achieved using the array-based digital microfluidic device.
authors.affiliation: Biomedical Engineering Department, McGill University, Montreal, QC H3A 2B4, Canada.
authors.forename: Lidija
authors.initials: L
authors.lastname: Malic
authors.forename: Teodor
authors.initials: T
authors.lastname: Veres
authors.forename: Maryam
authors.initials: M
authors.lastname: Tabrizian
mesh_terms: D004566:Electrodes; D004867:Equipment Design; D044085:Microfluidics / Q000295:instrumentation*; D020349:Surface Plasmon Resonance / Q000295:instrumentation*; D013499:Surface Properties; D017155:Wettability