Facile stereoselective synthesis of fluorinated flavanone derivatives via a one-pot tandem reaction.
A series of fluorinated flavanones were synthesized in moderate to good yields with excellent diastereoselectivities under mild reaction conditions via a one-pot tandem procedure involving a proline-catalyzed Knoevenagel condensation, a Michael addition, and an electrophilic fluorination by NFSI.
Cui
Haifeng
H
Laboratory of Modern Synthetic Organic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, People's Republic of China.
Li
Peng
P
Chai
Zhuo
Z
Zheng
Changwu
C
Zhao
Gang
G
Zhu
Shizheng
S
D044950:Flavanones / Q000138:chemical synthesis*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis; D013237:Stereoisomerism
D044950:Flavanones; D006845:Hydrocarbons, Fluorinated