Demonstration of 1-year duration of immunity for attenuated Bordetella bronchiseptica vaccines in dogs.
Three groups of healthy dogs with low antibody titers to Bordetella bronchiseptica (Bb), canine parainfluenza virus (CPI), and canine adenovirus type 2 (CAV-2) were used in this study. One group was vaccinated with a single dose of monovalent attenuated Bb vaccine and one group with a trivalent vaccine containing attenuated Bb, CPI, and CAV-2; dogs were vaccinated intranasally with a single dose of the respective vaccines. The third group served as unvaccinated controls. All vaccinated dogs subsequently developed serum antibody titers to Bb that persisted for at least 1 year. Following Bb challenge 1 year after vaccination, all vaccinated dogs, regardless of group, showed significantly fewer clinical signs and shed significantly fewer challenge organisms than unvaccinated controls. These results demonstrate that intranasal administration of a single dose of monovalent attenuated Bb vaccine or trivalent vaccine containing attenuated Bb, CPI, and CAV-2 provides 1 year of protection against Bb.
Lehar
Craig
C
Intervet/Schering-Plough Animal Health, Elkhorn, NE 68022, USA.
Jayappa
Huchappa
H
Erskine
Jason
J
Brown
Alicia
A
Sweeney
Diane
D
Wassmoen
Terri
T
D000257:Adenoviridae Infections / Q000517:prevention & control / Q000662:veterinary; D006516:Adenoviruses, Canine / Q000276:immunology; D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001885:Bordetella Infections / Q000517:prevention & control / Q000662:veterinary*; D016950:Bordetella bronchiseptica / Q000276:immunology*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D008297:Male; D022241:Parainfluenza Vaccines / Q000008:administration & dosage; D010223:Parainfluenza Virus 2, Human / Q000276:immunology; D011897:Random Allocation; D019351:Rubulavirus Infections / Q000517:prevention & control / Q000662:veterinary; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000008:administration & dosage*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D001428:Bacterial Vaccines; D022241:Parainfluenza Vaccines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines