Nickel-catalyzed cross-coupling of non-activated and functionalized alkyl halides with alkyl Grignard reagents.
Reacting in the 'Ni'ck of time: The title reaction is realized by using an isolated Ni(II) complex (1). The catalysis tolerates a wide range of important functional groups that are often incompatible with Grignard reagents in cross-coupling reactions.
Vechorkin
Oleg
O
Laboratory of Inorganic Synthesis and Catalysis, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne, ISIC-LSCI, BCH 3305, 1015 Lausanne, Switzerland.
Hu
Xile
X