Salidroside from Rhodiola sachalinensis protects neuronal PC12 cells against cytotoxicity induced by amyloid-beta.
The amyloid beta-peptide (Abeta)-induced oxidative stress is a well-established pathway of neuronal cell death in Alzheimer's disease (AD). Salidroside, one of the major compounds from the roots of Rhodiola species (Crassulaceae), was investigated in vitro for its cytoprotection against Abeta-induced toxicity on rat neuronal PCl2 cells. Salidroside significantly reduced Abeta-induced cytotoxicity in a dose-dependent manner. Salidroside also reduced Abeta-mediated intracellular accumulation of reactive oxygen species and malondialdehyde (MDA), a product of lipid peroxides, by preventing Abeta-induced decline of antioxidant enzyme activities. These results suggest that salidroside protects neuronal PC12 cells from Abeta-induced cytotoxicity via its antioxidant pathway.
Jang
S I
SI
Department of Microbiology and Immunology, Wonkwang University School of Medicine, Iksan, Chonbuk, South Korea.
Pae
H O
HO
Choi
B M
BM
Oh
G S
GS
Jeong
S
S
Lee
H J
HJ
Kim
H Y
HY
Kang
K J
KJ
Yun
Y G
YG
Kim
Y C
YC
Chung
H T
HT
D016229:Amyloid beta-Peptides / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016923:Cell Death; D002470:Cell Survival / Q000187:drug effects; D019610:Cytoprotection; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects*; D016716:PC12 Cells; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D018517:Plant Roots; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D029771:Rhodiola / Q000737:chemistry
D016229:Amyloid beta-Peptides; D000975:Antioxidants; D005960:Glucosides; D010636:Phenols; D017382:Reactive Oxygen Species; D008315:Malondialdehyde; C009172:rhodioloside