[Rhodiola sachalinensis suppresses T241 fibrosarcoma tumor cells proliferation in vitro and growth in vivo].
OBJECTIVE
To study the anticancer activity of Rhodiola sachalinensis in vitro and in vivo experiments.


METHODS
The effect of Rhodiola sachalinensis extracts at various concentrations on T241 fibrosarcoma cells proliferation and cytotoxic potential were measured. We divided T241 fibrosarcoma-bearing C57Bl6/J mice into two groups, the tumor inhibition rate were observed.


RESULTS
Rhodiola sachalinensis extracts inhibited T241 tumor cells growth in a dose-dependent manner. The concentrations of Rhodiola sachalinensis extracts from 50 microg/ml to 250 microg/ml did not reduced the survival rate of T241 tumor cells. The daily administration of Rhodiola sachalinensis resulted in a significant suppression of the growth of primary tumors, compared to control group, tumor inhibition rate in Rhodiola sachalinensis group reached 70.9%.


CONCLUSIONS
Rhodiola sachalinensis can inhibit T241 tumor cells growth and does not cause a direct cytotoxicity against tumor cells in vitro and in vivo.
Zhao
Xing
X
Department of Immunology, Guiyang Medical College, Guiyang 550004, China.
Zuo
Li
L
Zhong
Zhi-Qiang
ZQ
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005354:Fibrosarcoma / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry; D029771:Rhodiola / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts