title: Nasopharyngeal carcinoma in adolescents: a retrospective review of 42 patients.
abstract: The aim of the present study was to evaluate the characteristics and outcome of adolescent patients with nasopharyngeal carcinoma (NPC) disease. The study concerned 46 pediatric NPC patients treated during the period 1999-2002 at the National Institute of Oncology, Rabat. The median age of the patients was 16 years. The male/female ratio was 2.8/1. Histologically, all patients had undifferentiated carcinoma. A total of 93% presented nodal metastasis. Four (9%) had distant metastasis. All patients received neoadjuvant multiagent chemotherapy containing cisplatin, followed by radiotherapy. Kaplan-Meier curves were used to evaluate prognostic factors. The log-rank test was used to evaluate the differences between the groups. While none of the patients had locoregional failure, nine patients (29%) developed distant metastasis. The disease-free survival and overall survival (OS) rate for the entire group were 73 and 41%, respectively. Responders to chemotherapy had superior OS (P < 0.001). We suggest that combined modality management using multi-agent chemotherapy and RT as an effective treatment of NPC disease which will achieve satisfactory locoregional control and OS of NPC pediatric patients. Response to chemotherapy was an important prognostic factor.
authors.affiliation: Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco.
authors.forename: Said
authors.initials: S
authors.lastname: Afqir
authors.forename: Nabil
authors.initials: N
authors.lastname: Ismaili
authors.forename: Khaoula
authors.initials: K
authors.lastname: Alaoui
authors.forename: Samir
authors.initials: S
authors.lastname: Ahid
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Lotz
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Horn
authors.forename: Touria
authors.initials: T
authors.lastname: Bouhafa
authors.forename: Redouane
authors.initials: R
authors.lastname: Abouqal
authors.forename: Hassan
authors.initials: H
authors.lastname: Errihani
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002277:Carcinoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant; D002648:Child; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D020360:Neoadjuvant Therapy; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome