[Selective serotonin reuptake inhibitor is more likely to induce sexual dysfunction than mirtazapine in treating depression].
OBJECTIVE
To compare the incidences of sexual dysfunction induced by mirtazapine and SSRI in the treatment of patients with depression.


METHODS
Using key-word retrieval from the compact disks of the Chinese biological medicine (CBM) data base, we analyzed the rates of sexual dysfunction from the published clinical control trials on depression treated with mirtazapine and SSRI by applying the fixed effects model (FEM) of evidence-based medicine (EBM).


RESULTS
Among 1108 cases in 14 studies, there were 5 cases of mirtazapine-induced and 106 cases of SSRI-induced sexual dysfunction, accounting for 0.90% and 19.2% respectively, OR = 0.07 (95% CI: 0.04-0.14), Z = 8.03, P < 0.01.


CONCLUSIONS
SSRI is far more likely to induce sexual dysfunction than mirtazapine in the treatment of depression.
Chen
Zheng-xin
ZX
Department of Psychiatry, Zhejiang Province Mental Health Center, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
Wang
He-qiu
HQ
Jin
Wei-dong
WD
D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives*; D000078785:Mirtazapine; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
D000929:Antidepressive Agents, Tricyclic; D008803:Mianserin; D000078785:Mirtazapine; D017367:Selective Serotonin Reuptake Inhibitors