Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA).
OBJECTIVE
To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes.


METHODS
In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy.


RESULTS
After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident.


CONCLUSIONS
The lack of association between NMR-defined lipoproteins and DR does not support clinical use of NMR spectroscopy for management of patients with DR.
Kreis
Andreas J
AJ
Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia.
Wong
Tien Yin
TY
Islam
F M Amirul
FM
Klein
Ronald
R
Klein
Barbara E K
BE
Cotch
Mary Frances
MF
Jenkins
Alicia J
AJ
Shea
Steven
S
Wang
Jie Jin
JJ
D000328:Adult; D050197:Atherosclerosis / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005006:Ethnicity; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000145:classification; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D015203:Reproducibility of Results; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides