title: Fractal dimension analysis of grey matter in multiple sclerosis.
abstract: The fractal dimension (FD) is a quantitative parameter that characterizes the morphometric variability of a complex object. Among other applications, FD has been used to identify abnormalities of the human brain in conventional magnetic resonance imaging (MRI), including white matter abnormalities in patients with Multiple Sclerosis (MS). Extensive grey matter (GM) pathology has been recently identified in MS and it appears to be a key factor in long-term disability. The aim of the present work was to assess whether FD measurement of GM in T1 MRI sequences can identify GM abnormalities in patients with MS in the early phase of the disease. A voxel-based morphometry approach optimized for MS was used to obtain the segmented brain, where we later calculated the three-dimensional FD of the GM in MS patients and healthy controls. We found that patients with MS had a significant increase in the FD of the GM compared to controls. Such differences were present even in patients with short disease durations, including patients with first attacks of MS. In addition, the FD of the GM correlated with T1 and T2 lesion load, but not with GM atrophy or disability. The FD abnormalities of the GM here detected differed from the previously published FD of the white matter in MS, suggesting that different pathological processes were taking place in each structure. These results indicate that GM morphology is abnormal in patients with MS and that this alteration appears early in the course of the disease.
authors.affiliation: Department of Experimental Biology, Systems Biology Unit, Faculty of Experimental and Health Sciences, University of Jaén, Jaén, Spain. festeban@ujaen.es
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Esteban
authors.forename: Jorge
authors.initials: J
authors.lastname: Sepulcre
authors.forename: Juan Ruiz
authors.initials: JR
authors.lastname: de Miras
authors.forename: Juan
authors.initials: J
authors.lastname: Navas
authors.forename: Nieves Vélez
authors.initials: NV
authors.lastname: de Mendizábal
authors.forename: Joaquín
authors.initials: J
authors.lastname: Goñi
authors.forename: José M A
authors.initials: JM
authors.lastname: Quesada
authors.forename: Bartolome
authors.initials: B
authors.lastname: Bejarano
authors.forename: Pablo
authors.initials: P
authors.lastname: Villoslada
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D017709:Fractals; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009103:Multiple Sclerosis / Q000473:pathology*; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000473:pathology