title: [Effect of CDK2 on proliferation in laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  To investigate the role of CDK2 in the development of DNA heteroploid in laryngeal squamous cell carcinoma (LSCC).
  
  
  METHODS
  Fifty specimens of LSCC, twelve specimens of atypical hyperplasia and thirty specimens of vocal cord polyp were obtain during operation. Centrosome were detected by anti tubulin antibodies. Immunohistochemical method was used to analyze the protein expression of CDK2 and gamma-tubulin.
  
  
  RESULTS
  The positive rate of CDK2 and gamma-tubulin in LSCC were 68.0% (34/50) and 78.0% (10/15), all of them were significant higher than those in the vocal cord polyp (P<0.05). Expression of CDK2 in LSCC was positively association with expression of gamma-tubulin.
  
  
  CONCLUSIONS
  This experiment indicated that overexpression of CDK2 was strongly correlated with abnormal proliferation in LSCC, and it may be a valuable marker for the diagnosis and therapy of LSCC.
authors.affiliation: Department of Otolaryngology, the First Hospital of Medical University, Taiyuan, 030001, China. zhanghaili1975@yahoo.com.cn
authors.forename: Haili
authors.initials: H
authors.lastname: Zhang
authors.forename: Binquan
authors.initials: B
authors.lastname: Wang
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Shuxin
authors.initials: S
authors.lastname: Wen
authors.forename: Hui
authors.initials: H
authors.lastname: Huangfu
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged
chemical_list: C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2