title: Enhanced expression of interferon-inducible protein-10 correlates with disease activity and clinical manifestations in systemic lupus erythematosus.
abstract: Our objective was to investigate the serum levels of interferon-inducible protein-10 (IP-10) in systemic lupus erythematosus (SLE) and their correlation with disease activity and organ manifestations. Serum IP-10 levels were assessed in 464 SLE patients and 50 healthy donors. Disease activity was assessed by the revised SLE Activity Measure, and the concomitant active organ manifestations, anti-ds DNA antibody titres, complement levels and erythrocyte sedimentation rates recorded. Peripheral blood mononuclear cell (PBMC) synthesis of IP-10 in SLE patients and controls was determined by in vitro cultures stimulated with mitogen or lipopolysaccharide. Elevated serum IP-10 levels were observed in SLE patients, which were significantly higher in the presence of active haematological and mucocutaneous manifestations. SLE PBMCs exhibited enhanced spontaneous IP-10 production in vitro. Serial IP-10 levels correlated with longitudinal change in SLE activity, even at low levels where anti-dsDNA antibody and complement levels remain unchanged. These data demonstrate that IP-10 levels are increased in SLE and serum IP-10 may represent a more sensitive marker for monitoring disease activity than standard serological tests.
authors.affiliation: Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore.
authors.forename: K O
authors.initials: KO
authors.lastname: Kong
authors.forename: A W
authors.initials: AW
authors.lastname: Tan
authors.forename: B Y H
authors.initials: BY
authors.lastname: Thong
authors.forename: T Y
authors.initials: TY
authors.lastname: Lian
authors.forename: Y K
authors.initials: YK
authors.lastname: Cheng
authors.forename: C L
authors.initials: CL
authors.lastname: Teh
authors.forename: E T
authors.initials: ET
authors.lastname: Koh
authors.forename: H H
authors.initials: HH
authors.lastname: Chng
authors.forename: W G
authors.initials: WG
authors.lastname: Law
authors.forename: T C
authors.initials: TC
authors.lastname: Lau
authors.forename: K P
authors.initials: KP
authors.lastname: Leong
authors.forename: B P
authors.initials: BP
authors.lastname: Leung
authors.forename: H S
authors.initials: HS
authors.lastname: Howe
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002478:Cells, Cultured; D054357:Chemokine CXCL10 / Q000096:biosynthesis / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D015415:Biomarkers; D054357:Chemokine CXCL10