Coronary circulatory function abnormalities in insulin resistance: insights from positron emission tomography.
Traditionally, assessment of coronary circulatory function has been complex, requiring invasive techniques, including quantitative coronary angiography, intracoronary flow velocity probes, and pharmacologic stressor agents. However, radiotracer-based techniques for noninvasive measurement of myocardial blood flow are now available. Studies using these new techniques demonstrate that insulin resistance is associated with functional disturbances of the coronary circulation. Conversely, insulin infusion improves coronary flow, even in the setting of type 2 diabetes mellitus and coronary artery disease.
Schelbert
Heinrich R
HR
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, CA 90095-6948 , USA. hschelbert@mednet.ucla.edu
D003326:Coronary Circulation; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use*; D007333:Insulin Resistance; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D049268:Positron-Emission Tomography; D012307:Risk Factors; D015899:Tomography, Emission-Computed, Single-Photon
D007004:Hypoglycemic Agents; D007328:Insulin; D009569:Nitric Oxide