Published international classification of retinoblastoma (ICRB) definitions contain inconsistencies--an analysis of impact.
OBJECTIVE
To determine the impact of subtle differences (most notably in their classification of group E eyes) in two published versions of the ICRB (Philadelphia and the Children's Hospital Los Angeles).


METHODS
Analysis of a series of 96 eyes with intra-ocular retinoblastoma.


RESULTS
The disparate criteria of the 2 published ICRB schemas affected group assignment of 5.2% of the eyes (25% of the group E eyes).


CONCLUSIONS
Discrepancies need to be reconciled to ensure accurate and uniform application of the ICRB.
Novetsky
Danielle E
DE
Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
Abramson
David H
DH
Kim
Jonathan W
JW
Dunkel
Ira J
IJ
D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D038801:International Classification of Diseases / Q000592:standards*; D011642:Publications / Q000592:standards; D019572:Retinal Neoplasms / Q000145:classification* / Q000188:drug therapy / Q000401:mortality; D012175:Retinoblastoma / Q000145:classification* / Q000188:drug therapy / Q000401:mortality; D015996:Survival Rate
D000970:Antineoplastic Agents; D016190:Carboplatin