A meta-analysis of TP53 codon 72 polymorphism and lung cancer risk: evidence from 15,857 subjects.
The genetic polymorphism of TP53 codon 72 is thought to have significant effect on lung cancer risk, but the results are inconsistent. In this meta-analysis, we assessed 23 published studies involving 15,857 subjects of the association between TP53 codon 72 polymorphism and risk of lung cancer. For the homozygote Pro/Pro and Pro allele carriers (Pro/Pro+Pro/Arg), the ORs for all studies combined (7495 cases and 8362 controls) were 1.221 (95% CI=1.046-1.425; P=0.021 for heterogeneity) and 1.148 (95% CI=1.040-1.266; P=0.008 for heterogeneity). In the stratified analysis by ethnicity, significantly increased risks were found in Asians (3254 cases and 3350 controls) for both the homozygote Pro/Pro (OR=1.395; 95% CI=1.206-1.613; P=0.806 for heterogeneity) and the Pro allele carriers (OR=1.109; 95% CI=1.000-1.228; P=0.458 for heterogeneity). In Caucasians (3359 cases and 3953 controls), significantly elevated risk was associated with Pro allele carriers (OR=1.180; 95% CI=1.029-1.353; P=0.073 for heterogeneity). In the subgroup analyses by pathological type, the ORs for the homozygote Pro/Pro and Pro allele carriers were 1.289 (95% CI=1.027-1.618; P=0.096 for heterogeneity) and 1.168 (95% CI=1.062-1.284; P=0.231 for heterogeneity) for lung adenocarcinoma (2724 cases and 6591 controls). When stratified by smoking status, the pooled OR was 1.440 (95% CI=1.078-1.923; P=0.042 for heterogeneity) for the Pro allele carriers among smokers (1480 cases and 1414 controls). Although some statistical bias could not be eliminated, this meta-analysis suggests that the Pro allele is a low-penetrant risk factor for developing lung cancer. Additionally, we found that this phenomenon was more prominent in subgroups such as in Asians and Caucasians, in lung adenocarcinoma, or in smokers.
Li
Yan
Y
Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
Qiu
Li-Xin
LX
Shen
Xiao-Kun
XK
Lv
Xiao-Jing
XJ
Qian
Xiao-Ping
XP
Song
Yong
Y
D044466:Asian People / Q000235:genetics; D003062:Codon; D005787:Gene Frequency; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011392:Proline / Q000235:genetics; D012907:Smoking; D044465:White People / Q000235:genetics
D003062:Codon; D011392:Proline