Acute allergic reaction due to milk proteins contaminating lactose added to corticosteroid for injection.
We encountered two patients with severe cow's milk allergy who reacted strongly to an injection of methylprednisolone sodium succinate (Sol-Medrol 40 mg Pfizer, Japan). They came to our hospital because of an asthmatic attack or urticaria and were treated with Sol-Medrol 40 mg. After the injection, the allergic reaction was immediate. Skin prick tests demonstrated that the beta-lactoglobulin contaminating the lactose of the drug preparation caused the immediate allergic reaction.
Eda
Asuka
A
Children's Medical Center, Fujisawa City Hospital, Yokohama City, Kanagawa, Japan. asuka_milk@yahoo.co.jp
Sugai
Kazuko
K
Shioya
Hiromi
H
Fujitsuka
Asako
A
Ito
Setsuko
S
Iwata
Tsutomu
T
Funabiki
Tetsunori
T
D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D004340:Drug Contamination; D005260:Female; D006801:Humans; D007267:Injections; D007782:Lactoglobulins / Q000276:immunology*; D007785:Lactose / Q000032:analysis; D008776:Methylprednisolone Hemisuccinate / Q000009:adverse effects*; D016269:Milk Hypersensitivity / Q000209:etiology*
D007782:Lactoglobulins; D008776:Methylprednisolone Hemisuccinate; D007785:Lactose