title: Biphasic metaplastic sarcomatoid carcinoma of the breast: report of a case.
abstract: A 69-year-old woman was admitted to our hospital with the complaint of a right breast mass. As a result of thorough examinations, she was diagnosed with breast cancer and underwent breast-conserving surgery. The pathological findings of the resected specimen showed that the tumor consisted of intermingled carcinomatous and sarcomatous components with a transition zone. On immunohistochemical study, the sarcomatous cells in this transition zone showed partial positive staining for CD10, the myoepithelial marker, suggesting that the myoepithelial cells had transformed into sarcoma, and then this biphasic tumor was formed. Finally, she was diagnosed with biphasic metaplastic sarcomatoid carcinoma of the breast. Biphasic metaplastic sarcomatoid carcinoma of the breast is a relatively rare but aggressive disease. The pathological diagnosis is often controversial, requiring detailed immunohistochemical analysis. We report our experience with a case of biphasic metaplastic sarcomatoid carcinoma of the breast.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Tottori Prefectural Central Hospital, 730 Ezu, Tottori City, Tottori 680-0901, Japan. tomohiro19780703@yahoo.co.jp
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Haruki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Maeta
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sawazumi
authors.forename: Shigeto
authors.initials: S
authors.lastname: Miyasaka
authors.forename: Keisuke
authors.initials: K
authors.lastname: Morimoto
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Shu
authors.initials: S
authors.lastname: Nakamoto
authors.forename: Iwao
authors.initials: I
authors.lastname: Taniguchi
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008408:Mastectomy; D008679:Metaplasia / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery; D009361:Neoplasm Invasiveness; D017698:Postmenopause; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000000981:diagnostic imaging / Q000532:radiotherapy / Q000601:surgery; D016896:Treatment Outcome; D014463:Ultrasonography