title: Strategy for incorporating molecular and cytogenetic markers into acute myeloid leukemia therapy.
abstract: Acute myeloid leukemia is a heterogeneous disease. Standard treatments may be applied to biologically distinct subgroups, resulting in different treatment outcomes. The concept of risk-adapted therapy allows for recognition of this biologic diversity by incorporating key biologic features, such as cytogenetic and molecular markers, when formulating treatment regimens and investigating emerging targeted therapies based on disease characteristics.
authors.affiliation: Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA.
authors.forename: Mark G
authors.initials: MG
authors.lastname: Frattini
authors.forename: Peter G
authors.initials: PG
authors.lastname: Maslak
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000628:therapy*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers