title: Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants.
abstract: Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.
authors.affiliation: Fachbereich Chemie, Universität Konstanz, Germany.
authors.forename: B Gopal
authors.initials: BG
authors.lastname: Reddy
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Silk
authors.forename: Mariolina
authors.initials: M
authors.lastname: Salio
authors.forename: Rengarajan
authors.initials: R
authors.lastname: Balamurugan
authors.forename: Dawn
authors.initials: D
authors.lastname: Shepherd
authors.forename: Gerd
authors.initials: G
authors.lastname: Ritter
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Cerundolo
authors.forename: Richard R
authors.initials: RR
authors.lastname: Schmidt
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D014612:Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D006027:Glycosides; D014612:Vaccines