The oophorectomy effect on Walker 256 tumor inoculated into the vagina and uterine cervix of female rats.
OBJECTIVE
Verify the effect of oophorectomy on the evolution of the Walker 256 tumor inoculated into the vagina and cervix of female rats.


METHODS
Ten Wistar, female rats were used, distributed into two groups with 05 animals each: Tumor group (TG): Rats inoculated with Walker 256 tumor; Oophorectomy group (OG): oophorectomized rats inoculated with Walker 256 tumor. The day before the tumor vaginal inoculation, acetic acid was inoculated into the vaginas of both groups of rats; the following day, the vaginal walls were scarified with an endocervix brush, and then Walker 256 tumor was inoculated. After 12 days, the tumor was removed together with the vagina and uterine horns for macro and microscopic analyses. The data were submitted to statistical analyses.


RESULTS
There was no statistical difference between the two groups; however it was observed that the behavior of tumor growth on the OG group presented greater invasion, compromising the uterine horns.


CONCLUSIONS
The results of the study on the GO group presented a macroscopic behavior different from the TG group, however, both of them presented similar development in terms of tumor mass.
Brito
Nara Macedo Botelho
NM
Department of Specialized Health, Laboratory of Experimental Surgery, State University of Para (UEPA), Brazil. narabrito@amazon.com.br
Carvalho
Rita de Kássia Vidigal
Rde K
Matos
Lia Tavares de Moura Brasil
LT
Lobato
Rodolfo Costa
RC
Brito
Rosângela Baía
RB
D000704:Analysis of Variance; D000818:Animals; D002279:Carcinoma 256, Walker / Q000473:pathology*; D005260:Female; D009368:Neoplasm Transplantation / Q000379:methods; D010052:Ovariectomy; D051381:Rats; D017208:Rats, Wistar; D047368:Tumor Burden; D002583:Uterine Cervical Neoplasms / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000473:pathology*