A new wave in treatment of vascular occlusive disease: biodegradable stents--clinical experience and scientific principles.
Stent-based therapies in percutaneous vascular intervention are associated with significant long-term complications related to in-stent restenosis. A growing body of literature demonstrates the feasibility of biodegradable materials for endovascular stents, which may, in theory, circumvent many of the immunologic and inflammatory response issues seen with long-term metallic stent failure in coronary and peripheral applications. This review describes the history of endovascular stents and the challenges encountered with metallic, drug-eluting, and biodegradable stents. A review of the basic engineering principles of biodegradable stents is provided, along with a discussion of the cellular mechanisms of restenosis.
Brown
David A
DA
Department of Radiology, Division of Interventional Radiology, David Geffen School of Medicine, University of California Los Angeles Medical Center, Los Angeles, CA 90095-1721, USA.
Lee
Edward W
EW
Loh
Christopher T
CT
Kee
Stephen T
ST
D020341:Absorbable Implants / Q000639:trends*; D001157:Arterial Occlusive Diseases / Q000517:prevention & control*; D001807:Blood Vessel Prosthesis / Q000639:trends*; D002986:Clinical Trials as Topic; D006801:Humans; D015607:Stents / Q000639:trends*