Role of Panax ginseng as an antioxidant after cadmium-induced hepatic injuries.
Liver, being primary site for biotransformation of foreign compounds is vulnerable to various chemical assaults. Ginseng has a wide range of pharmacological and therapeutical action. In the present study an attempt has been made to study the cadmium chloride (CdCl(2)) induced toxicity in liver and its possible protection by Panax ginseng. Swiss albino mice were divided into four groups: (i) Control group--only vehicle (double distilled water) (ii) Ginseng treated group - 10mg/kg b.wt. orally (iii) CdCl(2) treated group - 1.0mg/kg b.wt. CdCl(2) i.p. (iv) Combination group--Ginseng root extract (10mg/kg b.wt.) and CdCl(2) (1.0mg/kg b.wt.). Activities of alkaline phosphatase, GOT, GPT were measured in serum and lipid peroxidation (LPO) and GSH content were measured in liver. The results indicated a significant increase in LPO, GOT, GPT activities and decrease in GSH and serum alkaline phosphatase activities after CdCl(2) treatment. Ginseng alone did not show any significant alterations except a significant decrease in LPO level. Combined treatment of Ginseng and CdCl(2) showed significant decrease in LPO, GOT, GPT and elevation in GSH and serum alkaline phosphatase as compared to CdCl(2) treated group. Thus, Ginseng is found to be protective against cadmium-induced hepatic injuries.
Shukla
Ritu
R
Department of Zoology, Cell and Molecular Biology Laboratory, University of Rajasthan, Jaipur, India.
Kumar
Madhu
M
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002104:Cadmium / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*
D000975:Antioxidants; D010936:Plant Extracts; D002104:Cadmium; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005978:Glutathione