title: Effects of interleukin-6 T15A single nucleotide polymorphism on baseline peritoneal solute transport rate in incident peritoneal dialysis patients.
abstract: OBJECTIVE
  To study the genetic effects of various inflammatory cytokines on peritoneal solute transport rate (PSTR) in incident Korean peritoneal dialysis (PD) patients.
  
  
  METHODS
  Case-control association study.
  
  
  METHODS
  132 patients with baseline peritoneal equilibration test within 1-3 months after starting PD were enrolled. We analyzed the influence of single nucleotide polymorphisms (SNPs) of interleukin-6 (IL-6; -572G/C, T15A), tumor necrosis factor-alpha (TNF-alpha; -1031C/T, -863C/A, -308G/A), and IL-10 (-1082A/G, -592A/C) on baseline PSTR. Clinical parameters such as age, gender, presence of diabetes mellitus, comorbidity, C-reactive protein, and residual renal function were also included as covariates.
  
  
  RESULTS
  The T15A SNP of IL-6 (rs13306435) was associated with PSTR. Patients with TA genotype (n=18) had significantly lower D4/P creatinine (0.65+/-0.087 vs 0.73+/-0.110, p=0.0046) and higher D4/D0 glucose (0.39+/-0.174 vs 0.31+/-0.119, p=0.027) than patients with TT genotype (n=114). The log value of the dialysate appearance rate of IL-6 had a strong positive correlation with D4/P creatinine (r2=0.1294, p<0.0001) and was significantly lower in the TA genotype than the TT genotype (201.7+/-14.42 vs 116.8+/-88.91 pg/minute, p=0.0358). By multiple logistic regression, TA genotype was negatively associated with a higher PSTR (high or high average; odds ratio 0.18; 95% confidence interval 0.048-0.666).
  
  
  CONCLUSIONS
  In incident Korean PD patients, T15A polymorphism of IL-6 is associated with dialysate IL-6 concentration and baseline PSTR.
authors.affiliation: Department of Internal Medicine, Eulji General Hospital, and Seoul National University, Seoul, Korea.
authors.forename: Young-Hwan
authors.initials: YH
authors.lastname: Hwang
authors.forename: Min-Jeong
authors.initials: MJ
authors.lastname: Son
authors.forename: Jaeseok
authors.initials: J
authors.lastname: Yang
authors.forename: Kiwon
authors.initials: K
authors.lastname: Kim
authors.forename: Wookyung
authors.initials: W
authors.lastname: Chung
authors.forename: Kwon-Wook
authors.initials: KW
authors.lastname: Joo
authors.forename: Yonsu
authors.initials: Y
authors.lastname: Kim
authors.forename: Curie
authors.initials: C
authors.lastname: Ahn
authors.forename: Kook-Hwan
authors.initials: KH
authors.lastname: Oh
mesh_terms: D001693:Biological Transport, Active / Q000235:genetics; D004247:DNA / Q000235:genetics*; D015314:Dialysis Solutions / Q000737:chemistry / Q000493:pharmacokinetics*; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis / Q000235:genetics* / Q000378:metabolism; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D007723:Korea; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000379:methods*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012189:Retrospective Studies
chemical_list: D015314:Dialysis Solutions; D015850:Interleukin-6; D004247:DNA