title: The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression.
abstract: BACKGROUND
  The neurotensin (NTS) and its specific high affinity G protein coupled receptor, the NT1 receptor (NTSR1), are considered to be a good candidate for one of the factors implicated in neoplastic progression. In breast cancer cells, functionally expressed NT1 receptor coordinates a series of transforming functions including cellular migration and invasion.
  
  
  RESULTS
  we investigated the expression of NTS and NTSR1 in normal human breast tissue and in invasive ductal breast carcinomas (IDCs) by immunohistochemistry and RT-PCR. NTS is expressed and up-regulated by estrogen in normal epithelial breast cells. NTS is also found expressed in the ductal and invasive components of IDCs. The high expression of NTSR1 is associated with the SBR grade, the size of the tumor, and the number of metastatic lymph nodes. Furthermore, the NTSR1 high expression is an independent factor of prognosis associated with the death of patients.
  
  
  CONCLUSIONS
  these data support the activation of neurotensinergic deleterious pathways in breast cancer progression.
authors.affiliation: INSERM-UPMC CDR Saint-Antoine EQ.5, Hôpital Saint-Antoine, Paris, France.
authors.forename: Sandra
authors.initials: S
authors.lastname: Dupouy
authors.forename: Véronique
authors.initials: V
authors.lastname: Viardot-Foucault
authors.forename: Marco
authors.initials: M
authors.lastname: Alifano
authors.forename: Frédérique
authors.initials: F
authors.lastname: Souazé
authors.forename: Geneviève
authors.initials: G
authors.lastname: Plu-Bureau
authors.forename: Marc
authors.initials: M
authors.lastname: Chaouat
authors.forename: Anne
authors.initials: A
authors.lastname: Lavaur
authors.forename: Danielle
authors.initials: D
authors.lastname: Hugol
authors.forename: Christian
authors.initials: C
authors.lastname: Gespach
authors.forename: Anne
authors.initials: A
authors.lastname: Gompel
authors.forename: Patricia
authors.initials: P
authors.lastname: Forgez
mesh_terms: D000368:Aged; D001706:Biopsy; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D004958:Estradiol / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D018028:Receptors, Neurotensin / Q000378:metabolism*
chemical_list: D018028:Receptors, Neurotensin; D004958:Estradiol