title: Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease.
abstract: Phosphoinositides function as signaling precursors as well as regulators and scaffolds of signaling molecules required for important cellular processes such as membrane trafficking. Although a picture of the biochemical and cell biological functions of phosphoinositides is emerging, less is known about how these functions impact signaling on a broader scale during development. This review summarizes recent work on the role of phosphoinositides in developmental signaling and in a number of diseases and developmental disorders.
authors.affiliation: The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, ON, Canada.
authors.forename: Lara C
authors.initials: LC
authors.lastname: Skwarek
authors.forename: Gabrielle L
authors.initials: GL
authors.lastname: Boulianne
mesh_terms: D000818:Animals; D001756:Blastoderm / Q000502:physiology; D019521:Body Patterning / Q000502:physiology; D002455:Cell Division; D016764:Cell Polarity; D004705:Endocytosis / Q000502:physiology; D054262:Gastrulation / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D009024:Morphogenesis / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010716:Phosphatidylinositols / Q000737:chemistry / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D063245:Plant Development; D010937:Plant Growth Regulators / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D010716:Phosphatidylinositols; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010937:Plant Growth Regulators; D020794:Receptor Protein-Tyrosine Kinases; D051880:Receptors, Notch