title: Psychiatric symptoms related to the use of lamotrigine: a review of the literature.
abstract: Lamotrigine is an established anticonvulsant agent and also an effective maintenance therapy for bipolar disorder. In Italy it is approved for the treatment of epilepsy with partial seizures, partial seizures with secondary generalization and generalized seizures, both in monotherapy and as an add-on therapy in patients with refractory epilepsy; it is also approved for the prevention of depressive episodes in patients with bipolar disorder with a predominant depressive component. Lamotrigine is generally well tolerated; however, some psychiatric problems have been reported in patients using the drug to treat mental disorders (mainly bipolar) or epilepsy. The clinical features of these psychiatric side effects are: affective switches, full acute psychotic episodes, and hallucinations. In conclusion, lamotrigine is an effective drug, very useful in the therapy of epilepsy and mood disorders, but clinicians have to be aware of the risk that it can induce psychiatric symptoms or acute episodes.
authors.affiliation: Psychiatric Emergency Service, Neuroscience and Mental Health Depaertment, S. Giovanni Battista Hospital, Corso Bramante, 88-10126 Turin, Italy. vvillari@molinette.piemonte.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Villari
authors.forename: Paola
authors.initials: P
authors.lastname: Rocca
authors.forename: Tiziana
authors.initials: T
authors.lastname: Frieri
authors.forename: Filippo
authors.initials: F
authors.lastname: Bogetto
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D000077213:Lamotrigine; D001523:Mental Disorders / Q000188:drug therapy*; D012196:Review Literature as Topic; D014227:Triazines / Q000627:therapeutic use*
chemical_list: D014227:Triazines; D000077213:Lamotrigine