Determinants of left main calcifications in a cohort of 2136 diabetes patients.
BACKGROUND
Left main (LM) calcification has been shown to be an independent predictor of mortality. Diabetes accelerates atherosclerosis and coronary artery calcification (CAC). In this study we aimed to describe the predictors of LM calcification in diabetes patients.


METHODS
From a database of >25,000 patients who have undergone CAC scanning at our institution, consecutive diabetic patients (n=2136) were evaluated for demographic data, CAC scores and coronary risk factors.


RESULTS
In our cohort 29.1% of patients had LM CAC. Of the classical atherosclerosis risk factors, in binary regression analysis, only age (OR 1.03 [1.017-1.043]), male gender (OR 1.59; p<0.05), hypertension (OR 1.73; p<0.05), and CAC score (OR 1.001; p<0.05) were found to be independently associated with LM disease.


CONCLUSIONS
The prevalence of LM CAC is high amongst diabetics (29.1%); associated with increased age, HTN and male sex.
Isma'eel
Hussain
H
Hamirani
Yasmin S
YS
Daga
Nikhil
N
Kadakia
Jigar
J
Mao
Songshuo
S
Ahmadi
Naser
N
Budoff
Matthew J
MJ
D000368:Aged; D002114:Calcinosis / Q000453:epidemiology*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000453:epidemiology*; D003920:Diabetes Mellitus / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors