title: [Formulation optimization of controlled porosity osmotic-pump tablets of total paeony glycosides].
abstract: OBJECTIVE
  To prepare controlled porosity osmotic-pump tablets of total paeony glycosides (TPG) and establish the relationship between formulation factors of membrane and drug release rate.
  
  
  METHODS
  Uniform design was used to achieve the quantitative relationship between the release rate and formulation factors of membrane. Optimized prescription was calculated from the regression equation.
  
  
  RESULTS
  A significant correlation and a fine precision of the regession equation were obtained. Controlled porosity osmotic-pump tablets of TPG were prepared based on the calculations, and the drug release profile was in accord with zero-order kinetics (r = 0.9902).
  
  
  CONCLUSIONS
  Uniform design is a convenient and efficient approach for formulation optimization of controlled porosity osmotic-pump tablets.
authors.affiliation: Sanjiu Medical & Pharmaceutical Co., Ltd., Shenzhen 518029, China. ycahui@163.com
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Wen-Ping
authors.initials: WP
authors.lastname: Wang
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D009997:Osmotic Pressure; D029596:Paeonia / Q000737:chemistry*; D016062:Porosity; D013607:Tablets / Q000737:chemistry*
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D013607:Tablets