title: Magnetic resonance spin-labeling perfusion imaging of synovitis in inflammatory arthritis at 3.0 T.
abstract: OBJECTIVE
  The aim of this study was to test the feasibility of arterial spin labeling (ASL) perfusion imaging of synovitis in inflammatory joint diseases on a clinical 3.0 T whole-body scanner.
  
  
  METHODS
  Fifteen patients (geometric mean 47 years, range 8-69 years) with different types of inflammatory arthritis of the finger or wrist joints participated in the study. In addition to conventional spin-echo and dynamic contrast-enhanced FLASH3D sequences, a novel spin-labeling technique (FAIR-TrueFISP) for quantitative assessment of tissue perfusion was applied. Perfusion maps were calculated pixel-wise by means of the extended Bloch equations.
  
  
  RESULTS
  Perfusion maps showed good image quality with clear visualization of hyperaemia in synovitis. The computed perfusion maps corresponded best to subtraction images of the dynamic series from 30 to 60 s after contrast-medium injection. The quantitative perfusion values of synovitis showed a good correlation with the disease activity. Perfusion values for inflamed synovium in phase of high activity were up to 230 ml/100 g tissue/min.
  
  
  CONCLUSIONS
  The proposed modality allows for the assessment of disease activity in arthritis without the application of contrast-medium offering a new tool for therapy monitoring. As the technique provides quantitative information on hyperaemia, it potentially offers new insights in the pathophysiology of arthritic diseases.
authors.affiliation: Section of Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard-Karls University of Tübingen, Hoppe-Seyler-Strasse 3, Tübingen, Germany. andreas.boss@med.uni-tuebingen.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Boss
authors.forename: Petros
authors.initials: P
authors.lastname: Martirosian
authors.forename: Jan
authors.initials: J
authors.lastname: Fritz
authors.forename: Ina
authors.initials: I
authors.lastname: Kötter
authors.forename: Jörg C
authors.initials: JC
authors.lastname: Henes
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Fritz
authors.initials: F
authors.lastname: Schick
authors.forename: Marius
authors.initials: M
authors.lastname: Horger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001168:Arthritis / Q000473:pathology*; D002648:Child; D003287:Contrast Media; D005260:Female; D005384:Finger Joint / Q000098:blood supply / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013113:Spin Labels; D013583:Synovial Membrane / Q000098:blood supply / Q000473:pathology; D013585:Synovitis / Q000473:pathology*; D014955:Wrist Joint / Q000098:blood supply / Q000473:pathology*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D013113:Spin Labels