title: 5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp.
abstract: Chemical investigations of the tropical marine sponge Hyrtios sp. have resulted in the isolation of a new alkaloid, 1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline (1) together with the known metabolites, 6-hydroxy-3,4-dihydro-1-oxo-beta-carboline (2), 5-hydroxy-1H-indole-3-carboxylic acid methyl ester (3), serotonin (4), hyrtiosin A (5), 5-hydroxyindole-3-carbaldehyde (6), and hyrtiosin B (7). Their structures were elucidated on the basis of mass spectrometry and detailed 2D NMR spectroscopic data. Hyrtiosin B (7) displayed a potent inhibitory activity against isocitrate lyase (ICL) of Candida albicans with an IC(50) value of 89.0 microM.
authors.affiliation: Marine Natural Products Laboratory, Korea Ocean Research and Development Institute, Ansan, PO Box 29, Seoul 425-600, Republic of Korea.
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Kyung-Mi
authors.initials: KM
authors.lastname: Yoon
authors.forename: Yu-Ri
authors.initials: YR
authors.lastname: Han
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Lee
authors.forename: Soon-Chun
authors.initials: SC
authors.lastname: Chung
authors.forename: Tae-Im
authors.initials: TI
authors.lastname: Kim
authors.forename: So-Hyoung
authors.initials: SH
authors.lastname: Lee
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000201:enzymology*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007522:Isocitrate Lyase / Q000037:antagonists & inhibitors*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*
chemical_list: C538701:1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline; C466377:5-hydroxyindole-3-carbaldehyde; D000935:Antifungal Agents; D002243:Carbolines; D026121:Indole Alkaloids; D007522:Isocitrate Lyase