Cognitive function in breast cancer survivors compared to healthy age- and education-matched women.
The cognitive function of breast cancer survivors (BC, n = 52) and individually matched healthy controls (n = 52) was compared on a battery of sensitive neuropsychological tests. The BC group endorsed significantly higher levels of subjective memory loss and scored significantly worse than controls on learning and delayed recall indices from the Rey Auditory Verbal Learning Test (AVLT). Defining clinically significant impairment as scores at or below the 7th percentile of the control group, the rate of cognitive impairment in the BC sample was 17% for total learning on the AVLT, 17% for delayed recall on the AVLT, and 25% for either measure. Findings indicate that a sizeable percentage of breast cancer survivors have clinically significant cognitive impairment.
Von Ah
Diane
D
Indiana University School of Nursing, Indianapolis, IN, USA.
Harvison
Kyle W
KW
Monahan
Patrick O
PO
Moser
Lyndsi R
LR
Zhao
Qianqian
Q
Carpenter
Janet S
JS
Sledge
George W
GW
Champion
Victoria L
VL
Unverzagt
Frederick W
FW
D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D000704:Analysis of Variance; D001943:Breast Neoplasms / Q000523:psychology*; D016022:Case-Control Studies; D003071:Cognition; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D013067:Speech Perception; D017741:Survivors / Q000523:psychology*; D014481:United States / Q000453:epidemiology; D014706:Verbal Learning