title: Comparison of the electrophysiologically based optimization methods with different pacing parameters in patient undergoing resynchronization treatment.
abstract: Many studies conducted on patients suffering from congestive heart failure have shown the efficacy of cardiac resynchronization therapy (CRT). The presented research investigates an off-line optimization algorithm based on different electrode positioning and timing delays. A computer model of the heart was used to simulate left bundle branch block (LBBB), myocardial infarction (MI) and reduction of intraventricular conduction velocity in order to customize the patient symptom. The optimization method evaluates the error between the healthy heart and pathology with/without pacing in terms of activation time and QRS length. Additionally, a torso model of the patient is extracted to compute the body surface potential map (BSPM) and to simulate the ECG with Wilson leads to validate the results obtained by the electrophysiological heart model optimization.
authors.affiliation: Institute of Biomedical Engineering, Universität Karlsruhe (TH), Kaiserstrasse 12, 76131, Germany. Raz.Miri@ibt.uni-karlsruhe.de
authors.forename: R
authors.initials: R
authors.lastname: Miri
authors.forename: M
authors.initials: M
authors.lastname: Reumann
authors.forename: D U J
authors.initials: DU
authors.lastname: Keller
authors.forename: D
authors.initials: D
authors.lastname: Farina
authors.forename: O
authors.initials: O
authors.lastname: Dössel
mesh_terms: D000465:Algorithms; D001698:Biomedical Engineering; D018780:Body Surface Potential Mapping; D002037:Bundle-Branch Block / Q000503:physiopathology / Q000628:therapy; D002304:Cardiac Pacing, Artificial / Q000379:methods* / Q000706:statistics & numerical data; D003198:Computer Simulation; D004562:Electrocardiography; D055724:Electrophysiological Phenomena; D006333:Heart Failure / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy