title: On the calculation of transcallosal conduction time using transcranial magnetic stimulation.
abstract: Transcallosal conduction time (TCT), based on the results of transcranial magnetic stimulation studies, is currently calculated as a function of the ipsilateral silent period (iSP) and of the motor evoked potential (MEP) obtained from a target muscle (TCTcurrent = iSP latency - MEP latency). We argue that this measure overestimates TCT and may lead to a bias in statistical group comparisons. We propose an alternative measure, TCTproposed, which we defined as TCTproposed = iSP latency - cSP latency, where cSP is the contralateral silent period. We report our results on the comparison of the two measures in twenty healthy individuals and provide a theoretical basis for TCTproposed.
authors.affiliation: Department of Neurology, G. Gennimatas Athens General Hospital, Athens, Greece. deftereo@gmail.com
authors.forename: Spyros N
authors.initials: SN
authors.lastname: Deftereos
authors.forename: Gregory
authors.initials: G
authors.lastname: Panagopoulos
authors.forename: Dimitra
authors.initials: D
authors.lastname: Georgonikou
authors.forename: Elissaios
authors.initials: E
authors.lastname: Karageorgiou
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Andriopoulos
authors.forename: Clementine E
authors.initials: CE
authors.lastname: Karageorgiou
mesh_terms: D000328:Adult; D055592:Biophysical Phenomena / Q000502:physiology*; D003337:Corpus Callosum / Q000502:physiology*; D004558:Electric Stimulation / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000502:physiology*; D012189:Retrospective Studies; D050781:Transcranial Magnetic Stimulation / Q000379:methods*