title: A new compound, brefeldin A formylate, from Penicillium sp. strain HLKG-44.
abstract: A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC(50) value of 18.9 microg/ml by the MTT assay protocol.
authors.affiliation: Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering, Department of Chemistry, Xiamen University, Xiamen, China.
authors.forename: Han-Wen
authors.initials: HW
authors.lastname: Zhang
authors.forename: Hong-Ming
authors.initials: HM
authors.lastname: Cheng
authors.forename: Hua
authors.initials: H
authors.lastname: Fang
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Zhao
authors.forename: Mei-Juan
authors.initials: MJ
authors.lastname: Fang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020126:Brefeldin A / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; C539298:brefeldin A formylate; D020126:Brefeldin A; D004875:Ergosterol