title: Multifocal skeletal tuberculosis in children.
abstract: Multifocal bone involvement is though rare but is reported from some countries where tuberculosis is endemic. Here we report a case of three years old boy was admitted in Bangabandhu Sheikh Mujib Medical University, Dhaka with the complaints of difficulty in walking ,low grade fever for six months, swelling over the back, elbow joint, knee joint and upper part of forearm and legs for two months. Family history of tuberculosis was positive. Mantoux test was 18 mm, ESR 85 mm in first hour, chest X-ray reveals right hilar lymphadenopathy, X-ray dorsolumber spine shows wedge shaped deformity in T11, L4 and with paravertebral collection from L2-L4. X-ray of legs, knee joint and forearms show multiple lytic lesions in shaft with periosteal reaction and cortical thickening. Ultrasonograph of whole abdomen shows psoas abscess. Culture of bone marrow aspirate reveals Mycobacterium tuberculosis. Patient was given an anti tubercular regimen with Rifampicin, Isoniazid, Pyrazinamide and Streptomycin for initial two months which to be followed by Rifampicin and Isoniazid for another 10 months.
authors.affiliation: Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Shahbag, Dhaka, Bangladesh. atiar777@yahoo.com
authors.forename: M A
authors.initials: MA
authors.lastname: Rahman
authors.forename: M
authors.initials: M
authors.lastname: Mutanabbi
authors.forename: M H
authors.initials: MH
authors.lastname: Rahman
authors.forename: K E
authors.initials: KE
authors.lastname: Arefin
authors.forename: M A
authors.initials: MA
authors.lastname: Helal
mesh_terms: D000904:Antibiotics, Antitubercular / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D011500:Protein Synthesis Inhibitors / Q000627:therapeutic use; D016659:Psoas Abscess / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D011718:Pyrazinamide / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D014394:Tuberculosis, Osteoarticular / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D011500:Protein Synthesis Inhibitors; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin