Rapid, general access to chiral beta-fluoroamines and beta,beta-difluoroamines via organocatalysis.
A rapid, general route to enantiopure beta-fluoroamines and beta,beta-difluoroamines has been developed employing organocatalysis in both a two-pot and a one-pot procedure. Both chemical yields (64-82%) and enantioselectivity (94-98% ee) were excellent and represent a significant improvement in the art of preparing chemically diverse beta-fluoroamines from readily available precursors.
Fadeyi
Olugbeminiyi O
OO
Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37232, USA.
Lindsley
Craig W
CW
D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000447:Aldehydes; D000588:Amines; D006845:Hydrocarbons, Fluorinated