title: Coincidence of central neurocytoma and multiple glioblastomas: a rare case report.
abstract: Coincidence of parenchymal primary brain tumors of different histogenesis is extremely rare. To the best of our knowledge, the present case of simultaneous appearance of a central neurocytoma and multiple glioblastomas is the first to be reported. Multiple intraaxial brain neoplasms were disclosed in a 39-year-old man and were surgically resected. Histological diagnosis of the tumor located in the right lateral ventricle was central neurocytoma whereas two tumors of the left temporal lobe were glioblastomas. The latter were located in close proximity to the subarachnoid space, had atypical radiological appearance, and were slightly positive for synaptophysin and neurofilament protein. It can be speculated that both malignant neoplasms were, in fact, dedifferentiated central neurocytoma, which developed from distant tumor deposits. This case seems to be in agreement with the hypothesis that central neurocytoma arises from the progenitor cells with potential for both neuronal and glial differentiation. Better understanding of histogenesis of this tumor is definitely needed.
authors.affiliation: Department of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Shinjuku-ku, Japan. ymuragaki@nij.twmu.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Muragaki
authors.forename: Mikhail
authors.initials: M
authors.lastname: Chernov
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tajika
authors.forename: Osami
authors.initials: O
authors.lastname: Kubo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iseki
authors.forename: Tomokatsu
authors.initials: T
authors.lastname: Hori
authors.forename: Kintomo
authors.initials: K
authors.lastname: Takakura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D019070:Cell Lineage; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D004569:Electroencephalography; D005909:Glioblastoma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D018306:Neurocytoma / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D019635:Neurosurgical Procedures; D015376:Nimustine / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015376:Nimustine; D014750:Vincristine