title: Effect of gender on theophylline clearance in the asthmatic acute phase in Japanese pediatric patients.
abstract: The effect of gender on theophylline clearance was investigated retrospectively in 96 Japanese pediatric patients (63 males and 33 females) ranging in age from 0.5 to 8 years and in weight from 6.3 to 36.8 kg. All patients received intravenous constant-rate infusion of aminophylline in the asthmatic acute phase. The theophylline clearances in males and females were 56.2+/-15.4 and 50.1+/-14.2 ml/h/kg for ages 0.5-<2 years, 58.7+/-18.8 and 48.3+/-6.5 ml/h/kg for ages 2-<4 years, and 65.7+/-12.0 and 52.1+/-16.8 ml/h/kg for ages 4-<9 years, respectively. At ages from 2 to 8 years, the theophylline clearance was 20% higher in males than in females (p<0.05). Our findings suggested that the initial dosage of theophylline should be adjusted according to the gender of pediatric patients and particularly in the case of infants.
authors.affiliation: Department of Pharmacy, Itami City Hospital, Hyogo, Japan. igarashi-hhp@umin.net
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Igarashi
authors.forename: Seigo
authors.initials: S
authors.lastname: Iwakawa
mesh_terms: D000208:Acute Disease; D000375:Aging / Q000378:metabolism; D018927:Anti-Asthmatic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001249:Asthma / Q000188:drug therapy / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D006801:Humans; D007223:Infant; D008297:Male; D010101:Oxygen Consumption / Q000502:physiology; D011239:Prednisolone / Q000494:pharmacology; D012727:Sex Characteristics; D013726:Terbutaline / Q000494:pharmacology; D013806:Theophylline / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D018927:Anti-Asthmatic Agents; D000893:Anti-Inflammatory Agents; D011239:Prednisolone; D013806:Theophylline; D013726:Terbutaline