Expression of androgen receptor in mammary glands in ovariectomized cynomolgus monkeys.
This study investigated structural alterations and the immunohistochemical expression of androgen receptor (AR), estrogen receptor (ER), and progesterone receptor (PgR) in the mammary glands from surgically postmenopausal cynomolgus monkeys (Macaca fascicularis). Fourteen animals were divided into 2 groups. Seven animals underwent an ovariectomy (OVX), and the other 7 animals underwent a sham operation (sham). The in-life phase of study was 78 weeks. Atrophy in the mammary glands of OVX monkeys was similar to early postmenopausal atrophy of the human breast. The proportion of AR-positive cells in the OVX group was significantly higher than in the sham group, but the proportion of ER and PgR-positive cells was significantly lower. These results suggest that use of a primate model for hormone receptor expression has potential applications in basic human endocrinology, particularly in research in hormone receptor expression in mammary glands (both normal and neoplastic).
Kawaguchi
H
H
Department of Tumor Pathology, Field of Oncology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan. kawa@m3.kufm.kagoshima-u.ac.jp
Umekita
Y
Y
Fukuzaki
K
K
Maeda
H
H
Miyajima
H
H
Nagata
R
R
Yoshida
H
H
D000818:Animals; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D008252:Macaca fascicularis; D008321:Mammary Glands, Animal / Q000378:metabolism* / Q000473:pathology; D010052:Ovariectomy / Q000662:veterinary*; D011944:Receptors, Androgen / Q000235:genetics / Q000378:metabolism*
D011944:Receptors, Androgen