title: The molecular and cellular biology of enhanced cognition.
abstract: Most molecular and cellular studies of cognitive function have focused on either normal or pathological states, but recent research with transgenic mice has started to address the mechanisms of enhanced cognition. These results point to key synaptic and nuclear signalling events that can be manipulated to facilitate the induction or increase the stability of synaptic plasticity, and therefore enhance the acquisition or retention of information. Here, we review these surprising findings and explore their implications to both mechanisms of learning and memory and to ongoing efforts to develop treatments for cognitive disorders. These findings represent the beginning of a fundamental new approach in the study of enhanced cognition.
authors.affiliation: Department of Neurobiology, Brain Research Institute, University of California, Los Angeles, California 90095, USA.
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Lee
authors.forename: Alcino J
authors.initials: AJ
authors.lastname: Silva
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D003071:Cognition / Q000502:physiology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008967:Molecular Biology / Q000379:methods*; D009473:Neuronal Plasticity / Q000235:genetics* / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium