title: Synthesis of citrate-ciprofloxacin conjugates.
abstract: Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.
authors.affiliation: Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
authors.forename: Siti R
authors.initials: SR
authors.lastname: Md-Saleh
authors.forename: Emily C
authors.initials: EC
authors.lastname: Chilvers
authors.forename: Kevin G
authors.initials: KG
authors.lastname: Kerr
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Milner
authors.forename: Anna M
authors.initials: AM
authors.lastname: Snelling
authors.forename: Jan P
authors.initials: JP
authors.lastname: Weber
authors.forename: Gavin H
authors.initials: GH
authors.lastname: Thomas
authors.forename: Anne-Kathrin
authors.initials: AK
authors.lastname: Duhme-Klair
authors.forename: Anne
authors.initials: A
authors.lastname: Routledge
mesh_terms: D002939:Ciprofloxacin / Q000138:chemical synthesis* / Q000494:pharmacology; D019343:Citric Acid / Q000138:chemical synthesis* / Q000494:pharmacology; D048168:Escherichia coli K12 / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D017353:Gene Deletion; D006801:Humans; D018272:Porins / Q000172:deficiency / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development
chemical_list: C109237:OmpF protein; D018272:Porins; D019343:Citric Acid; D002939:Ciprofloxacin