title: Joint analysis of differential mobility spectrometer and mass spectrometer features for tuberculosis biomarkers.
abstract: In this article, we present results of recent efforts to identify biomarkers for tuberculosis using a differential mobility spectrometer (DMS). We focus specifically on the capability of exploiting a data collection system that employs a DMS in parallel with a mass spectrometer. This system permits previously developed algorithms for DMS to be used in conjunction with a device considered a gold-standard for chemical identification, making it a unique discovery tool for the determination of biomarkers.
authors.affiliation: Mission Systems Division, Draper Laboratory, Cambridge, MA 02492, USA. mgerber@draper.com
authors.forename: Meredith G
authors.initials: MG
authors.lastname: Cunha
authors.forename: Shirley
authors.initials: S
authors.lastname: Hoenigman
authors.forename: Chitra
authors.initials: C
authors.lastname: Kanchagar
authors.forename: Preshious
authors.initials: P
authors.lastname: Rearden
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Sassetti
authors.forename: Jose M
authors.initials: JM
authors.lastname: Trevejo
authors.forename: Nirmal
authors.initials: N
authors.lastname: Keshava
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000032:analysis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000175:diagnosis* / Q000378:metabolism*
chemical_list: D015415:Biomarkers