Neuroprotective protein and carboxypeptidase E.
This review outlines the neuroprotective activities and structural specificities of two distinct proteins, activity-dependent neuroprotective protein, a protein assigned transcription factor/chromatin remodeling activity, and carboxypeptidase E, a classic exopeptidase. Future studies will elucidate how these two versatile proteins converge onto a similar endpoint: neuroprotection.
Koshimizu
Hisatsugu
H
Section on Cellular Neurobiology, Program on Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Senatorov
Vladimir
V
Loh
Y Peng
YP
Gozes
Illana
I
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D001921:Brain / Q000166:cytology / Q000378:metabolism; D043423:Carboxypeptidase H / Q000235:genetics / Q000378:metabolism*; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D018696:Neuroprotective Agents / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
C117632:Adnp protein, mouse; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D043423:Carboxypeptidase H