title: TP53 codon 72 polymorphism is associated with age at onset of glioblastoma.
abstract: BACKGROUND
  Functional single nucleotide polymorphisms (SNP) in codon 72 of TP53 have been shown to be a risk factor, a prognostic marker, and related factor to age at onset in various cancers.
  
  
  METHODS
  We investigated blood samples from 254 patients with glioblastoma and 238 healthy controls.
  
  
  RESULTS
  TP53 codon 72 status was not correlated with prognosis and did not differ between glioblastoma and control populations. However, the Pro/Pro genotype was overrepresented in patients <45 years (20.6% vs 6.4% in patients with glioblastoma >45 years, p = 0.002, vs 5.9% in control group, p = 0.001). We then confirmed this result on an independent series of young patients with glioblastoma. Finally, the analysis of tumor DNA found the Pro allele associated with occurrence of TP53 somatic mutation.
  
  
  CONCLUSIONS
  Our data suggest that TP53 functional variation is particularly critical for oncogenesis of glioblastoma in young patients.
authors.affiliation: INSERM, U711, Biologie des Interactions Neurones & Glie, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: El Hallani
authors.forename: F
authors.initials: F
authors.lastname: Ducray
authors.forename: A
authors.initials: A
authors.lastname: Idbaih
authors.forename: Y
authors.initials: Y
authors.lastname: Marie
authors.forename: B
authors.initials: B
authors.lastname: Boisselier
authors.forename: C
authors.initials: C
authors.lastname: Colin
authors.forename: F
authors.initials: F
authors.lastname: Laigle-Donadey
authors.forename: M
authors.initials: M
authors.lastname: Rodéro
authors.forename: O
authors.initials: O
authors.lastname: Chinot
authors.forename: J
authors.initials: J
authors.lastname: Thillet
authors.forename: K
authors.initials: K
authors.lastname: Hoang-Xuan
authors.forename: J-Y
authors.initials: JY
authors.lastname: Delattre
authors.forename: M
authors.initials: M
authors.lastname: Sanson
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D003062:Codon / Q000097:blood / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005909:Glioblastoma / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000097:blood / Q000235:genetics*; D055815:Young Adult
chemical_list: D003062:Codon; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53