Copper(I)-catalyzed synthesis of substituted 2-mercapto benzimidazoles.
An efficient method for the preparation of various substituted 2-mercapto benzimidazoles from their corresponding thioureas has been developed. S-alkylation of thioureas followed by Cu-catalyzed intramolecular N-arylation furnished substituted 2-mercapto benzimidazoles in high yields and short reaction times. Furthermore, 2-mercapto benzimidazoles substituted with a p-methoxybenzyl group allowed access to benzimidazole thiones.
Murru
Siva
S
Institut de Chimie Moléculaire de Reims, UMR 6229 CNRS-Université de Reims Champagne-Ardenne, UFR des Sciences exactes et naturelles, BP 1039, 51687 REIMS Cedex 2, France.
Patel
Bhisma K
BK
Le Bras
Jean
J
Muzart
Jacques
J
D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D001562:Benzimidazoles; D003300:Copper