[Synapse remodelling from functional to structural: neural mechanisms underlying amblyopia].
Visual experience plays an instructive role in the development of the visual nervous system., it can induce persistent modification of developing visual circuits via Hebb's synaptic plasticity. The application of in vivo two-photon imaging to monitor structural changes during Monocular deprivation (MD) will determine how amblyopia are related to remodelling of synapses. As the most important process of amblyopia, ocular dominance (OD) shifts served as a usefull model for examining how cortical circuits are shaped by experience. MD can induce OD shifts toward the no-visual deprivation eye, what are the neuronal mechanisms underlying it? How the functional plasticity turn to structural plasticity? Do the adults share the common mechanisms with the juveniles? In this review we will discuss the researching progress of neuronal mechanisms of amblyopia in these years.
Xie
Lai-qing
LQ
Tianjin Eye Hospital, Clinical College of Ophthalmology of Tianjin Medical University, Tianjin 300020, China.
Zhao
Kan-xing
KX
D000550:Amblyopia / Q000473:pathology / Q000503:physiopathology*; D023882:Dominance, Ocular; D006801:Humans; D009473:Neuronal Plasticity; D012683:Sensory Deprivation; D013569:Synapses / Q000648:ultrastructure*