[Hyponatraemia as a clinical manifestation of hypopituitarism caused by neurosarcoidosis].
Severe hyponatraemia was observed in a 35-year-old man with progressive malaise; this was caused by hypopituitarism and secondary hypocortisolism as a result ofneurosarcoidosis. Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology which can develop in any of the body's organs or tissues. The central nervous system is affected in only 5-15% of patients with sarcoidosis. Neurosarcoidosis is a rare disorder with clinical heterogeneity. Extensive diagnostic procedures, including MRI of the cerebrum and histological investigation, and structural outpatient follow-up are mandatory in patients in whom neurosarcoidosis is suspected. Treatment consists mainly of high-dose corticosteroids, which usually have to be taken long-term. Clinical course and prognosis are variable, and depend on the accompanying symptoms.
de Jong
P H P
PH
Afd. Interne Geneeskunde, Albert Schweitzer Ziekenhuis, locatie Dordwijk, Postbus 444, 3300 AK Dordrecht. php-de-jong@hotmail.com
van Leendert
R J M
RJ
de Waal
M
M
van Bommel
E F H
EF
D000328:Adult; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology*; D007018:Hypopituitarism / Q000209:etiology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009422:Nervous System Diseases / Q000503:physiopathology*; D010902:Pituitary Gland / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D012507:Sarcoidosis / Q000503:physiopathology*