title: [Cox proportional hazard model analysis of prognosis in patients with carcinoma of esophagus and gastric cardia after radical resection].
abstract: OBJECTIVE
  To investigate the factors affecting the long-term survival of patients with carcinoma of esophagus and gastric cardia after curative resection.
  
  
  METHODS
  The clinical data of 906 patients with carcinoma of esophagus and gastric cardia treated by radical resection in 1996 - 2004 were analyzed retrospectively. Twelve clinicopathological factors possibly influencing survival were encoded and assessed by Cox regression analysis.
  
  
  RESULTS
  The 1-, 3- and 5-year cumulative survival rates were 89.8%, 75.4% and 71.7%, respectively. The univariate analysis showed that age, length of tumor, pathological differentiation, number of metastatic lymph nodes, depth of invasion, involvement of adjacent organs and the TNM stage influenced the prognosis significantly (P < 0.01). However, multivariate analysis showed that pathologic differentiation, number of metastatic lymph nodes, involvement of adjacent organs and TNM stage were independent prognostic factors (P < 0.05).
  
  
  CONCLUSIONS
  The independent prognostic factors of the patients with carcinoma of esophagus and gastric cardia are pathologic differentiation, TNM stage, number of metastatic lymph nodes, and involvement of adjacent organs. The other factors influencing survival are age, length of tumor and depth of invasion. Furthermore, invasion of adjacent organs suggests worse prognosis, and should be followed-up closely.
authors.affiliation: Department of Medical Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Xi-Shan
authors.initials: XS
authors.lastname: Hao
authors.forename: Qian
authors.initials: Q
authors.lastname: Fan
authors.forename: Hai-Xin
authors.initials: HX
authors.lastname: Li
authors.forename: Li-Nan
authors.initials: LN
authors.lastname: Song
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Wang
authors.forename: Pei-Zhong
authors.initials: PZ
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Jin
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Li-Yun
authors.initials: LY
authors.lastname: Guan
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Ping
authors.forename: Xian-Li
authors.initials: XL
authors.lastname: Meng
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Jun-Feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Wang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002299:Cardia; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate