[Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats].
OBJECTIVE
To study effects of Yuquan pills on the pharmacokinetics process of metformin hydrochloride in diabetic rats.


METHODS
After administration Yuquan pills 7 day to the diabetic rats, the metformin hydrochloride was orally administrated, then the blood samples were collected at different time. The concentrations of metformin hydrochloride in plasma were determined by HPLC method and the pharmacokinetic parameters were calculated.


RESULTS
The pharmacokinetic parameter Cmax of the controlling group and the testing group were respectively, 18.95, 21.76 mg x L(-1); t1/2 were 1,069.8, 1,767.4 min, respectively; CL/F were 0.013, 0.008 L x min(-1) x kg(-1); AUC were 10,042.1, 10,712.2 mg z L(-1) x min(-1) respectively.


CONCLUSIONS
The pharmacokinetics process of metformin hydrochloride in diabetic rats fits one-compartment model. Yuquan pills has a significant effect on the pharmacokinetics of metformin hydrochloride in diabetic rats.
Duan
Hao-Gang
HG
Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou 730000, China. duanhg06@163.com
Wei
Yu-Hui
YH
Li
Bo-Xia
BX
Zhang
Dong-Mei
DM
Zhang
Jin-Wen
JW
Wu
Xin-An
XA
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; D008687:Metformin