title: The effect of casein phosphopeptide-amorphous calcium phosphate on erosive enamel and dentine wear by toothbrush abrasion.
abstract: OBJECTIVE
  In addition to its role as a remineralizing agent in preventing dental caries, calcium product (CPP-ACP) delivered as a mousse (Tooth Mousse, TM) can reduce erosion of enamel and dentine. The aim of this study was to determine whether CPP-ACP could also reduce erosive tooth wear involving toothbrush abrasion.
  
  
  METHODS
  Flat, polished enamel and dentine specimens (n=72) were subjected to 10 wear regimes, with each regime involving erosion in 0.3% citric acid (pH 3.2) for 10 min followed by toothbrush abrasion in a slurry of fluoride-free toothpaste and artificial saliva (1:3 ratio by weight) under a load of 2N for 200 cycles. The specimens were immersed in artificial saliva for 2h between wear regimes. In the experimental group 1, TM (containing CPP-ACP) was applied at the beginning of each wear episode for 5 min whereas TM- (without CPP-ACP) was applied in the experimental group 2. No mousse was applied in the control group.
  
  
  RESULTS
  TM significantly reduced enamel wear (mean+/-S.E., 1.26+/-0.33 microm in the experimental group 1 vs 3.48+/-0.43 microm in the control group) and dentine wear (2.16+/-0.89 microm in the experimental group 1 vs 10.29+/-1.64 microm in the control group), and dentine wear was significantly less in the experimental group 1 than in the experimental group 2 (5.75+/-0.98 microm).
  
  
  CONCLUSIONS
  The finding that TM reduced erosive tooth wear involving toothbrush abrasion, probably by remineralizing and lubricating eroded tooth surfaces, may have implications in the management of tooth wear.
authors.affiliation: School of Dentistry, The University of Adelaide, Adelaide, SA 5005, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Ranjitkar
authors.forename: J M
authors.initials: JM
authors.lastname: Rodriguez
authors.forename: J A
authors.initials: JA
authors.lastname: Kaidonis
authors.forename: L C
authors.initials: LC
authors.lastname: Richards
authors.forename: G C
authors.initials: GC
authors.lastname: Townsend
authors.forename: D W
authors.initials: DW
authors.lastname: Bartlett
mesh_terms: D002130:Calcium Phosphates / Q000627:therapeutic use; D002364:Caseins / Q000627:therapeutic use*; D003743:Dental Enamel / Q000187:drug effects*; D003802:Dentifrices / Q000627:therapeutic use*; D003804:Dentin / Q000187:drug effects*; D006801:Humans; D015233:Models, Statistical; D008964:Molar, Third; D010748:Phosphopeptides / Q000627:therapeutic use; D014072:Tooth Abrasion / Q000209:etiology; D014077:Tooth Erosion / Q000209:etiology / Q000517:prevention & control*; D014089:Tooth Remineralization / Q000379:methods; D014099:Toothbrushing / Q000009:adverse effects
chemical_list: D002130:Calcium Phosphates; D002364:Caseins; D003802:Dentifrices; D010748:Phosphopeptides; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex