1,4-Naphthoquinone is a potent inhibitor of human cancer cell growth and angiogenesis.
Angiogenesis inhibitors are beneficial for the prevention and treatment of angiogenesis-dependent diseases including cancer. Vitamin K2 and K3, which are naphthoquinone derivatives, inhibit angiogenesis. We examined the anti-cancer and anti-angiogenic effects of naphthoquinones and its structurally related compounds. Among these 13 compounds, 1,4-naphthoquinone strongly inhibited both human colon cancer cell (HCT116) growth and angiogenesis. To clarify the anti-angiogenic mechanism, the effects of 1,4-naphthoquinone on human umbilical vein endothelial cell (HUVEC) tube formation, proliferation and chemotaxis were examined. Consequently, 1,4-naphthoquinone inhibited HUVEC functions. These results suggest that 1,4-naphthoquinone may be useful to cancer therapy.
Kayashima
Tomoko
T
Department of Human Life Science Education, Graduate School of Education, Hiroshima University, 111 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-8524, Japan.
Mori
Masaharu
M
Yoshida
Hiromi
H
Mizushina
Yoshiyuki
Y
Matsubara
Kiminori
K
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects*; D045744:Cell Line, Tumor / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D005263:Femoral Artery; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008297:Male; D009285:Naphthoquinones / Q000494:pharmacology* / Q000627:therapeutic use; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D014471:Umbilical Veins / Q000166:cytology / Q000187:drug effects
D000970:Antineoplastic Agents; D009285:Naphthoquinones; C035342:1,4-naphthoquinone