Functional evaluation of magnetic microactuators for removing biological accumulation: an in vitro study.
Here we demonstrate the functional capability of microfabricated magnetic actuators in clearing biological accumulation on a model catheter pore. Cell-clearing performance was quantitatively measured by comparing the effect of actuation on the cell density of aggressively growing adherent murine cells. Devices were actuated at a frequency of 100 Hz and a magnetic field of 17.8 kA/m for 30, 45, or 60 min. On average, microactuators removed 37.4% of the adherent cells. The results also revealed that the cell-clearing capability of the microactuator increased as a function of the actuation duration and angle of deflection.
Lee
Selene A
SA
NeuroEngineering Training Program, University of California, Los Angeles, Los Angeles, CA 90095 USA.
Pinney
James R
JR
Khialeeva
Elvira
E
Bergsneider
Marvin
M
Judy
Jack W
JW
D018407:Bacterial Physiological Phenomena / Q000528:radiation effects*; D004203:Disinfection / Q000295:instrumentation* / Q000379:methods; D004866:Equipment Contamination / Q000517:prevention & control*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008280:Magnetics / Q000295:instrumentation*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D008904:Miniaturization; D019736:Prostheses and Implants / Q000009:adverse effects / Q000382:microbiology*; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000517:prevention & control*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013314:Stress, Mechanical; D014159:Transducers