title: Catalytic, enantioselective ring opening of aziridines.
abstract: Cooperative metal centers in a bimetallic catalyst facilitate the highly enantioselective ring opening of meso aziridines 1 with silyl nucleophiles (see scheme; TMS = trimethylsilyl). The 1,2-azidoamides 2 and 1,2-amidonitriles 3 obtained in this way in high yields and with up to 99% ee are valuable precursors to enantiomerically pure 1,2-diamines and beta-amino acids.
authors.affiliation: Institut für Organische Chemie, Universität Leipzig, Johannisallee 29, 04103 Leipzig, Germany. schneider@chemie.uni-leipzig.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Schneider