Blood coagulation and cancer: thrombosis and survival, clinical relevance and impact. An introduction.
There is a strong association between deep venous thrombosis and cancer. In this review, we will discuss the increased incidence of cancer following an idiopathic venous thrombotic event (VTE) and the increased incidence of VTE and its recurrence in cancer patients. Furthermore, we will review the adverse impact VTE has on cancer patients' morbidity and mortality. Finally, the potential influence of anticoagulation on survival of cancer patients is discussed. Although the data are encouraging, anticoagulation is still of limited value for routine clinical practice in anticancer treatment.
Vestjens
J H M J
JH
Department of Medical Oncology, Academic Hospital Maastricht, Maastricht, The Netherlands.
Sassen
S
S
Prins
M H
MH
D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects; D016022:Case-Control Studies; D002405:Catheterization, Central Venous / Q000009:adverse effects; D015331:Cohort Studies; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D015994:Incidence; D009369:Neoplasms / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000401:mortality / Q000503:physiopathology; D009382:Neoplasms, Unknown Primary / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012008:Recurrence; D019851:Thrombophilia / Q000139:chemically induced / Q000188:drug therapy / Q000209:etiology*; D020246:Venous Thrombosis / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology / Q000517:prevention & control
D000925:Anticoagulants; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal