In vitro cyto-biocompatibility and cell detachment of temperature-sensitive dextran hydrogel.
A series of poly(NIPAAm-co-GMA-Dex) hydrogels were synthesized from glycidyl methacrylate-derivatized dextran (GMA-Dex) and N-isopropylacrylamide (NIPAAm) in aqueous solution. The swelling properties, cell culture and detachment behaviors of these hydrogels were investigated. It has found that poly(NIPAAm-co-GMA-Dex) hydrogels are not only sensitive to temperature in deionized water and Dulbecco's modified eagle medium (DMEM) (10% FBS), but also exhibit good biocompatibility. In addition, L929 cells were found to detach from the hydrogel surface naturally without affecting the function of L929 by controlling environmental temperature.
Xiao
Fei
F
Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300160, China.
Chen
Li
L
Xing
Rui-Feng
RF
Zhao
Yi-Ping
YP
Dong
Jing
J
Guo
Gang
G
Zhang
Rui
R
D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods*
D001672:Biocompatible Materials; D020100:Hydrogels