Exploring the association between elevated body mass index and Barrett's esophagus: a systematic review and meta-analysis.
We performed a systematic review and meta-analysis to study the association between elevated body mass index (BMI) and Barrett's esophagus (BE). Cross-sectional, case-control and cohort studies published through February 2008 that met strict inclusion and exclusion criteria were included. Summary estimates were calculated for the association between BE and being either overweight (BMI > or = 25 kg/m(2)) or obese (BMI > or = 30 kg/m(2)), or both. Based on 11 studies included in this analysis, there was a statistically significant relationship between increasing BMI and BE. Further studies are needed to evaluate if the presence of reflux attenuates the strength of this relationship, and if a particular pattern of obesity is more strongly associated with BE.
Kamat
Paresh
P
Division of Gastroenterology, The Mount Sinai Medical Center, New York, New York 10029, USA.
Wen
Sijin
S
Morris
Jeffrey
J
Anandasabapathy
Sharmila
S
D000328:Adult; D017677:Age Distribution; D001471:Barrett Esophagus / Q000175:diagnosis / Q000453:epidemiology*; D015992:Body Mass Index; D016022:Case-Control Studies; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000175:diagnosis / Q000453:epidemiology*; D011379:Prognosis; D012720:Severity of Illness Index; D017678:Sex Distribution