title: Receptor-mediated targeting of cathepsins in professional antigen presenting cells.
abstract: Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.
authors.affiliation: Leiden Institute of Chemistry, Leiden University, P.O. Box 9052, 2300 RA Leiden, The Netherlands.
authors.forename: Ulrik
authors.initials: U
authors.lastname: Hillaert
authors.forename: Martijn
authors.initials: M
authors.lastname: Verdoes
authors.forename: Bogdan I
authors.initials: BI
authors.lastname: Florea
authors.forename: Athanasios
authors.initials: A
authors.lastname: Saragliadis
authors.forename: Anastasios
authors.initials: A
authors.lastname: Saragliadis
authors.forename: Kim L L
authors.initials: KL
authors.lastname: Habets
authors.forename: Johan
authors.initials: J
authors.lastname: Kuiper
authors.forename: Serge
authors.initials: S
authors.lastname: Van Calenbergh
authors.forename: Ferry
authors.initials: F
authors.lastname: Ossendorp
authors.forename: Gijsbert A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: Christoph
authors.initials: C
authors.lastname: Driessen
authors.forename: Hermen S
authors.initials: HS
authors.lastname: Overkleeft
mesh_terms: D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002403:Cathepsins / Q000378:metabolism*; D002478:Cells, Cultured; D037181:Lectins, C-Type / Q000378:metabolism; D007930:Leucine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: C419228:DCG 04; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D002403:Cathepsins; D007930:Leucine