Comparing the therapeutic effects of finasteride gel and tablet in treatment of the androgenetic alopecia.
BACKGROUND
Finasteride, a type II-selective 5alpha-reductase inhibitor, as a causative agent of decreasing dihydroxy testosterone (DHT) level, is effective in the treatment of male androgenic alopecia.


OBJECTIVE
We compared the local and oral finasteride in the treatment of androgenic alopecia.


METHODS
This is a double blind, randomized clinical trial study of 45 male patients, who were referred with alopecia to the private clinics and departments in Boo-Ali Sina Hospital, in Sari. Patients with male androgenic alopecia were selected according to the history and physical examinations. The patients were randomly divided into two: topical finasteride (A) and oral finasteride (B) groups. Topical finasteride group (A) received a topical gel of 1% finasteride and placebo tablets, while the oral finasteride group (B) received finasteride tablets (1 mg) and gel base (without drug) as placebo for 6 months. The patients were followed by clinical observation and recording of side effects prior to the treatment and at the end of first week, and then by a monthly follow-up. The size of bald area, total hair count, and terminal hair were studied. Data were analyzed by descriptive and Chi-square statistical test.


RESULTS
The mean duration of hair loss was 18.8+/-23.10 months. Each month the terminal hair, size of bald area and hair count between the two groups were compared. There were no significant differences between the two groups as a viewpoint of hair thickness, hair counts and the size of bald area. Serial measurements indicated a significant increase in hair counts and terminal hair counts between the two groups.


CONCLUSIONS
The results of this study showed that the therapeutic effects of both finasteride gel and finasteride tablet were relatively similar to each other.
Hajheydari
Zohreh
Z
Department of Dermatology, Boo Ali Sina (Avicenna) Hospital, Mazandaran University of Medical Sciences, Sari, Iran. zhajheydari@yahoo.com
Akbari
Jafar
J
Saeedi
Majid
M
Shokoohi
Leila
L
D000287:Administration, Topical; D000328:Adult; D000505:Alopecia / Q000188:drug therapy* / Q000473:pathology*; D002626:Chemistry, Pharmaceutical; D004311:Double-Blind Method; D018120:Finasteride / Q000008:administration & dosage*; D005782:Gels; D006801:Humans; D008297:Male; D013607:Tablets; D016896:Treatment Outcome; D055815:Young Adult
D005782:Gels; D013607:Tablets; D018120:Finasteride