Investigation of T2-weighted signal intensity of infarcted myocardium and its correlation with delayed enhancement magnetic resonance imaging in a porcine model with reperfused acute myocardial infarction.
To assess the signal pattern in T2-weighted images (T2WI) and determine its relation to persistent microvascular obstruction (PMO) and intramyocardial hemorrhage in a porcine model with reperfused acute myocardial infarction. Left anterior descending artery was occluded (90 or 180 min) and reperfused (90 min). T2WI and delayed-enhanced magnetic resonance images (DE-MRI) were acquired. The T2WI signal pattern, T2WI contrast ratio, PMO, and intramyocardial hemorrhage were evaluated, and their interrelationships were analyzed. The infarct area on T2WI was recorded as a homogeneous high-intensity signal or as low- or iso-intensity signals. The contrast ratio of the T2WI in the cases with PMO was significantly lower than that in those without PMO (1.38 +/- 0.25 vs. 1.89 +/- 0.31, P < 0.05), and it showed significant inverse correlation with the extent of PMO observed in DE-MRI images (r =-0.8, P < 0.05). The extent of PMO correlated strongly with that of intramyocardial hemorrhage (r = 0.97, P < 0.05). The abnormal signal area in the T2WI was larger than the infarct area in the DE-MRI images (47.0 +/- 9.9% vs. 37.8 +/- 9.9%, P < 0.05) and the infarct area observed after TTC staining (47.0 +/- 9.9% vs. 37.4 +/- 8.4%, P < 0.05). We observed variable T2WI signal patterns for the infarcted myocardium. Lower T2WI contrast ratios significantly correlated with the extent of PMO in DE-MRI and intramyocardial hemorrhage in the gross specimen.
Choi
Seong Hoon
SH
Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Kang
Joon-Won
JW
Kim
Sang-Tae
ST
Lee
Byung Han
BH
Chun
Eun Ju
EJ
Schuleri
Karl H
KH
Choi
Sang Il
SI
Lim
Tae-Hwan
TH
D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation; D004195:Disease Models, Animal; D006470:Hemorrhage / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008833:Microcirculation; D009203:Myocardial Infarction / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000473:pathology*; D012720:Severity of Illness Index; D013552:Swine
D003287:Contrast Media