[Retina radioresistance: whole-body exposure of mice to gamma-irradiation induces the retina DNA damage, accumulation of p53 protein followed by DNA repair rather than the apoptosis].
Whole-body irradiation of mice with gamma-rays at 14 Gy causes DNA single and double strand breaks effectively repaired later. p53 is accumulated during the repair period. There is still some amount of DNA breaks 48-72 hours after the irradiation. Despite p53 accumulation and residual DNA lesions in the cells, mice retina demonstrated no morphological destructive changes or apoptosis signs. Retina resistance to apoptotic signals could derive from efficient repair of radiation-induced lesions in transcriptionally active regions of the genome of differentiated cells.
Loginova
M Iu
MIu
Tronov
V A
VA
Beletskaia
T A
TA
Fel'dman
T B
TB
Panova
I G
IG
Ostrovskiĭ
M A
MA
D000818:Animals; D017209:Apoptosis; D004247:DNA / Q000235:genetics / Q000528:radiation effects*; D004249:DNA Damage; D004260:DNA Repair; D005260:Female; D005720:Gamma Rays / Q000009:adverse effects*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011836:Radiation Tolerance; D012160:Retina / Q000502:physiology / Q000528:radiation effects* / Q000648:ultrastructure; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014916:Whole-Body Irradiation
D016159:Tumor Suppressor Protein p53; D004247:DNA