The distinct roles of JAM-A in reovirus pathogenesis.
Despite their fundamental role in host defense, many components of epithelial and endothelial tight junctions serve as viral receptors. In this issue of Cell Host & Microbe, Antar et al. (2009) provide striking in vivo evidence that the broadly expressed reovirus receptor JAM-A plays a specific role in reovirus dissemination.
Coyne
Carolyn B
CB
Department of Cell Biology and Physiology, University of Pittsburgh, Pittsburgh, PA 15261, USA. coynec2@pitt.edu
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D051379:Mice; D011956:Receptors, Cell Surface / Q000502:physiology*; D011991:Receptors, Virus / Q000502:physiology*; D012087:Reoviridae / Q000502:physiology*; D012088:Reoviridae Infections / Q000821:virology*
D015815:Cell Adhesion Molecules; C498686:F11r protein, mouse; D011956:Receptors, Cell Surface; D011991:Receptors, Virus