A simple modification of GE tracerlab FX C Pro for rapid sequential preparation of [11C]carfentanil and [11C]raclopride.
A simple modification of the GE Tracerlab FX C Pro system which enabled performance of both solvent capture (loop method) and conventional solution phase [(11)C]methylation in the same module is described. By the quick setup and automated method, [(11)C]carfentanil and [(11)C]raclopride could be prepared in rapid succession without opening the hot cell. The radiochemical yields were over 40% and 30% (decay-corrected and based on [(11)C]methyl iodide) for [(11)C]carfentanil and [(11)C]raclopride, respectively. The radiochemical purities were greater than 95% and specific activities over 5 Ci/mmol for both tracers. The modification is extremely easy and can be utilized for multiple syntheses of other (11)C-labeled radiopharmaceuticals in a fast and reliable manner.
Shao
Xia
X
Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA. xshao@umich.edu
Kilbourn
Michael R
MR
D002250:Carbon Radioisotopes / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D020891:Raclopride / Q000138:chemical synthesis* / Q000737:chemistry; D011874:Radiometry; D013056:Spectrophotometry, Ultraviolet
D002250:Carbon Radioisotopes; D020891:Raclopride; C017114:carfentanil; D005283:Fentanyl