The precision of remote context memories does not require the hippocampus.
Although the clarity of many memories fades with time, some memories may maintain their original precision. Here we used a context discrimination procedure to evaluate whether the hippocampus is important in maintaining precision as memories mature. Spared discrimination in hippocampal-lesioned mice indicated that precise, remote context memories may be supported by extra-hippocampal brain regions.
Wang
Szu-Han
SH
Program in Neurosciences and Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, M5G 1X8, Canada.
Teixeira
Cátia M
CM
Wheeler
Anne L
AL
Frankland
Paul W
PW
D000818:Animals; D004193:Discrimination Learning / Q000502:physiology*; D005239:Fear / Q000502:physiology; D006624:Hippocampus / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors