title: Depth of anaesthesia monitoring in obese patients: a randomized study of propofol-remifentanil.
abstract: BACKGROUND
  In obese patients, depth of anaesthesia monitoring could be useful in titrating intravenous anaesthetics. We hypothesized that depth of anaesthesia monitoring would reduce recovery time and use of anaesthetics in obese patients receiving propofol and remifentanil.
  
  
  METHODS
  We investigated 38 patients with a body mass index >or=30 kg/m(2) scheduled for an abdominal hysterectomy. Patients were randomized to either titration of propofol and remifentanil according to a cerebral state monitor (CSM group) or according to usual clinical criteria (control group). The primary end point was time to eye opening and this was assessed by a blinded observer.
  
  
  RESULTS
  Time to eye opening was 11.8 min in the CSM group vs. 13.4 min in the control group (P=0.58). The average infusion rate for propofol was a median of 516 vs. 617 mg/h (P=0.24) and for remifentanil 2393 vs. 2708 microg/h (P=0.04). During surgery, when the cerebral state index was continuously between 40 and 60, the corresponding optimal propofol infusion rate was 10 mg/kg/h based on ideal body weight.
  
  
  CONCLUSIONS
  No significant reduction in time to eye opening could be demonstrated when a CSM was used to titrate propofol and remifentanil in obese patients undergoing a hysterectomy. A significant reduction in remifentanil consumption was found.
authors.affiliation: Department of Anaesthesia, Centre of Head and Orthopaedics, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. meyhoff@rh.dk
authors.forename: C S
authors.initials: CS
authors.lastname: Meyhoff
authors.forename: S W
authors.initials: SW
authors.lastname: Henneberg
authors.forename: B G
authors.initials: BG
authors.lastname: Jørgensen
authors.forename: M R
authors.initials: MR
authors.lastname: Gätke
authors.forename: L S
authors.initials: LS
authors.lastname: Rasmussen
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D000758:Anesthesia / Q000379:methods*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009765:Obesity / Q000601:surgery; D010880:Piperidines / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology*; D000077208:Remifentanil
chemical_list: D010880:Piperidines; D000077208:Remifentanil; D015742:Propofol