An approach to thermodynamically controlled supramolecular assembly possessing an integral locking mechanism.
A general approach for thermodynamically controlled molecular assembly employing carbonyl addition chemistry is exemplified with a prototypical rotaxane synthesis. Recognition-driven assembly of the rotaxane proceeds under conditions of mild base catalysis, while subsequent treatment with catalytic acid triggers a dehydrative locking mechanism and fixes the evolved molecular architecture in place.
Cagulada
Amy M
AM
Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA.
Hamilton
Darren G
DG