Genomic location of the bovine growth hormone secretagogue receptor (GHSR) gene and investigation of genetic polymorphism.
The growth hormone secretagogue receptor (GHSR) is involved in the regulation of energetic homeostasis and GH secretion. In this study, the bovine GHSR gene was mapped to BTA1 between BL26 and BMS4004. Two different bovine GHSR CDS (GHSR1a and GHSR1b) were sequenced. Six polymorphisms (five SNPs and one 3-bp indel) were also identified, three of them leading to amino acid variations L24V, D194N, and Del R242. These variations are located in the extracellular N-terminal end, the exoloop 2, and the cytoloop 3 of the receptor, respectively.
Colinet
F G
FG
Animal and Microbial Biology Unit, Gembloux Agricultural University, Gembloux, Belgium.
Vanderick
S
S
Charloteaux
B
B
Eggen
A
A
Gengler
N
N
Renaville
B
B
Brasseur
R
R
Portetelle
D
D
Renaville
Robert
R
D000818:Animals; D002417:Cattle / Q000235:genetics*; D002874:Chromosome Mapping; D023281:Genomics; D008297:Male; D011110:Polymorphism, Genetic; D054440:Receptors, Ghrelin / Q000235:genetics*
D054440:Receptors, Ghrelin