RUNX proteins in transcription factor networks that regulate T-cell lineage choice.
Recent research has uncovered complex transcription factor networks that control the processes of T-cell development and differentiation. RUNX (runt-related transcription factor) proteins are among the many factors that have crucial roles in these networks. In this Review, we examine the mechanisms by which RUNX complexes act together with other transcription factors, such as Th-POK (T-helper-inducing POZ/Kruppel-like factor) and GATA-binding protein 3 (GATA3) in determining the CD4/CD8 lineage choice of developing thymocytes. In addition, we discuss evidence indicating that RUNX complexes are also involved in the differentiation of effector T-cell subsets and that the molecular mechanisms by which RUNX proteins regulate T-cell fate decisions are conserved between the thymus and periphery.
Collins
Amélie
A
The Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA.
Littman
Dan R
DR
Taniuchi
Ichiro
I
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D019070:Cell Lineage / Q000235:genetics* / Q000276:immunology; D050657:Core Binding Factor alpha Subunits / Q000235:genetics / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis; D050990:GATA3 Transcription Factor / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D038041:Lymphopoiesis / Q000235:genetics*; D013950:Thymus Gland / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D050657:Core Binding Factor alpha Subunits; D016207:Cytokines; D050990:GATA3 Transcription Factor; D014157:Transcription Factors; C494749:GATA3 protein, human; C497211:Zbtb7b protein, mouse