Computational study of an augmented minimal model for glycaemia control.
In this paper we introduce a new model structure for the metabolic effects of intravenous insulin on blood glucose in man and derive its parameter values from the widely used model of Sorensen. The proposed model attempts to combine the advantages of the existing comprehensive and minimal models. Validation of the new model is done through deriving equivalent nonparametric nonlinear models in the form of Principal Dynamic Modes. We show that the new structure can represent the insulin-glucose dynamics of healthy subjects as well as Type 1 and Type 2 diabetics, with appropriate adjustment in its parameters.
Markakis
Mihalis G
MG
Electrical Engineering & Computer Science Department, Massachusetts Institute of Technology, USA. mihalis@mit.edu
Mitsis
Georgios D
GD
Marmarelis
Vasilis Z
VZ
D001786:Blood Glucose / Q000378:metabolism*; D003198:Computer Simulation; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism*; D004360:Drug Therapy, Computer-Assisted / Q000379:methods*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007275:Injections, Intravenous; D007328:Insulin / Q000008:administration & dosage* / Q000097:blood*; D008954:Models, Biological
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin