title: Effect of dietary docosahexaenoic acid connecting phospholipids on the lipid peroxidation of the brain in mice.
abstract: The effect of dietary docosahexaenoic acid (DHA, C22:6n-3) with two lipid types on lipid peroxidation of the brain was investigated in streptozotocin (STZ)-induced diabetic mice. Each group of female Balb/c mice was fed a diet containing DHA-connecting phospholipids (DHA-PL) or DHA-connecting triacylglycerols (DHA-TG) for 5 wk. Safflower oil was fed as the control. The lipid peroxide level of the brain was significantly lower in the mice fed the DHA-PL diet when compared to those fed the DHA-TG and safflower oil diets, while the alpha-tocopherol level was significantly higher in the mice fed the DHA-PL diet than in those fed the DHA-TG and safflower oil diets. The DHA level of phosphatidylethanolamine in the brain was significantly higher in the mice fed the DHA-PL diet than in those fed the safflower oil diet. The dimethylacetal levels were significantly higher in the mice fed the DHA-PL diet than in those fed the safflower oil and DHA-TG diets. These results suggest that the dietary DHA-connecting phospholipids have an antioxidant activity on the brain lipids in mice, and the effect may be related to the brain plasmalogen.
authors.affiliation: Shizuoka Prefectural Research Institute of Fishery, Yaizu, Shizuoka, Japan. seiichi1_hiratsuka@pref.shizuoka.lg.jp
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hiratsuka
authors.forename: Kenji
authors.initials: K
authors.lastname: Ishihara
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kitagawa
authors.forename: Shun
authors.initials: S
authors.lastname: Wada
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Yokogoshi
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D004281:Docosahexaenoic Acids / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D010053:Ovary / Q000737:chemistry*; D010714:Phosphatidylethanolamines / Q000737:chemistry; D010743:Phospholipids / Q000008:administration & dosage; D012450:Safflower Oil / Q000494:pharmacology; D014280:Triglycerides / Q000008:administration & dosage; D014413:Tuna; D024502:alpha-Tocopherol / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D007328:Insulin; D008054:Lipid Peroxides; D010714:Phosphatidylethanolamines; D010743:Phospholipids; D014280:Triglycerides; D004281:Docosahexaenoic Acids; C483858:phosphatidylethanolamine; D012450:Safflower Oil; D002784:Cholesterol; D024502:alpha-Tocopherol