Synthesis and promotion angiogenesis effect of chrysin derivatives coupled to NO donors.
Two types of new chrysin derivatives were prepared by coupling NO donors of alkyl nitrate and furazan derivatives and were fully characterized by (1)H NMR and other techniques. These compounds were tested in human umbilical vein endothelial cells (HUVECs-12) and all the compounds exhibited cell proliferation. Notable effects of promoting angiogenesis were observed for all the modified compounds using chick chorioallantoic membrane (CAM) assay.
Peng
Sheng-Ming
SM
Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, PR China.
Zou
Xiao-Qing
XQ
Ding
Hua-Lan
HL
Ding
Yong-Lan
YL
Lin
Yuan-Bin
YB
D043925:Angiogenesis Inducing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply* / Q000378:metabolism; D042783:Endothelial Cells / Q000187:drug effects*; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009566:Nitrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000378:metabolism; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology
D043925:Angiogenesis Inducing Agents; D005419:Flavonoids; D009566:Nitrates; D020030:Nitric Oxide Donors; D010069:Oxadiazoles; C043561:chrysin