An efficient carbene-catalyzed access to 3,4-dihydrocoumarins.
Dihydrocoumarins play an important role as flavor and fragrance compounds and can be prepared efficiently from o-hydroxycinnamaldehydes in a mild, atom-economic N-heterocyclic carbene-catalyzed redox lactonization. Corresponding coumarins are accessible via a one-pot domino oxidation lactonization procedure in the presence of oxidants.
Zeitler
Kirsten
K
Institut für Organische Chemie, Universität Regensburg, D-93053 Regensburg, Germany. kirsten.zeitler@chemie.uni-regensburg.de
Rose
Christopher A
CA