A general method for the synthesis of unsymmetrically substituted ureas via palladium-catalyzed amidation.
A general and practical method for the preparation of unsymmetrically substituted ureas has been developed utilizing palladium-catalyzed amidation. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietary bipyrazole ligand (bippyphos).
Kotecki
Brian J
BJ
Abbott Laboratories, GPRD Process Research and Development, Dept. R450, Bldg. R8, 1401 Sheridan Road, North Chicago, Illinois 60064, USA. brian.kotecki@abbott.com
Fernando
Dilinie P
DP
Haight
Anthony R
AR
Lukin
Kirill A
KA
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D010165:Palladium; D014508:Urea