title: Molecular mechanisms underlying the effects of sex steroids on bone and mineral metabolism.
abstract: The multifarious functions of sex steroid receptors include a role as regulatory factors for bone and mineral metabolism in vivo. These functions are more complex than originally assumed. The finding of nuclear receptors in osseous tissue alludes to the existence of novel indirect and direct functions of bone tissue beyond skeletal support, hematopoiesis, and calcium homeostasis. Cell-specific gene targeting approaches are an extremely important technology for future studies that will need to be conducted to fully understand the molecular mechanisms underlying bone formation and metabolism.
authors.affiliation: Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abenoku, Osaka, Osaka 545-8585, Japan. imai@med.osaka-cu.ac.jp
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Imai
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Kunio
authors.initials: K
authors.lastname: Takaoka
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Kato
mesh_terms: D000818:Animals; D017209:Apoptosis; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D006801:Humans; D008903:Minerals / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D012739:Gonadal Steroid Hormones; D008903:Minerals; D011944:Receptors, Androgen; D011960:Receptors, Estrogen