The association of red blood cell counts with endothelin-1 in African and Caucasian women.
The literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association of erythrocytes and endothelin-1 in women of different ethnicities was investigated. Blood pressure, vascular resistance, and C-reactive protein (P = 0.09) were significantly higher in the African women (n = 102) compared to the Caucasian women (n = 115), while arterial compliance was significantly lower in the African women with no significant differences for endothelin-1. In single, partial, and multiple regression analyses, there was a significant positive correlation between the red blood cell count and log endothelin-1 in the Caucasians while in the Africans there was a weak negative correlation. This is an indication that endothelin-1 might interfere with erythrocyte production in Africans with higher levels of inflammation.
Huisman
Hugo W
HW
Subject Group Physiology, North-West University, Private Bag, Potchefstroom, South Africa. Hugo.Huisman@nwu.ac.za
Schutte
Aletta E
AE
van Rooyen
Johannes M
JM
Schutte
Rudolph
R
Malan
Leoné
L
Fourie
Catatharina M T
CM
Malan
Nicolass T
NT
D000328:Adult; D044383:Black People; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D019332:Endothelin-1 / Q000097:blood*; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D013019:South Africa; D014655:Vascular Resistance; D044465:White People
D019332:Endothelin-1; D002097:C-Reactive Protein