title: Ru(III)-based compounds with sulfur donor ligands: synthesis, characterization, electrochemical behaviour and anticancer activity.
abstract: In recent years, Ru(iii) complexes have emerged as a new class of effective anticancer agents against tumors that proved to be resistant to all other chemotherapeutic drugs currently in clinical use. To extend our previous studies on metal complexes containing sulfur-donor ligands, we report here on the synthesis and characterization, by means of several spectroscopic and analytical techniques, some [Ru(RSDT)(3)] and [Ru(2)(RSDT)(5)]Cl complexes with dithiocarbamato ligands derived from methyl/ethyl/tert-butyl esters of sarcosine. Their electrochemical behaviour was also studied by cyclic voltammetry. All the complexes were tested for their cytotoxicity on a panel of human tumor cell lines showing highly significant antitumor activity. The chemical and biological properties of the newly synthesized complexes, were compared with those of [Ru(DMDT)(3)] and [Ru(2)(DMDT)(5)]Cl species (DMDT = N,N-dimethyldithiocarbamate) whose chemical (not biological) characterization has been already reported in literature.
authors.affiliation: Department of Chemical Sciences, University of Padova, Via Marzolo 1, 35131, Padova, Italy.
authors.forename: Lorena
authors.initials: L
authors.lastname: Giovagnini
authors.forename: Sergio
authors.initials: S
authors.lastname: Sitran
authors.forename: Ignazio
authors.initials: I
authors.lastname: Castagliuolo
authors.forename: Paola
authors.initials: P
authors.lastname: Brun
authors.forename: Maddalena
authors.initials: M
authors.lastname: Corsini
authors.forename: Piero
authors.initials: P
authors.lastname: Zanello
authors.forename: Alfonso
authors.initials: A
authors.lastname: Zoleo
authors.forename: Annalisa
authors.initials: A
authors.lastname: Maniero
authors.forename: Barbara
authors.initials: B
authors.lastname: Biondi
authors.forename: Dolores
authors.initials: D
authors.lastname: Fregona
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004553:Electric Conductivity; D004563:Electrochemistry; D004578:Electron Spin Resonance Spectroscopy; D004952:Esters / Q000737:chemistry; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008731:Methoxychlor / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012428:Ruthenium / Q000737:chemistry*; D012521:Sarcosine / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D013455:Sulfur / Q000737:chemistry*; D013818:Thermogravimetry; D013859:Thiocarbamates / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D008024:Ligands; D009942:Organometallic Compounds; D013859:Thiocarbamates; D013455:Sulfur; D012428:Ruthenium; D008731:Methoxychlor; D012521:Sarcosine