title: Nanoscale oxidative patterning of metallic surfaces to modulate cell activity and fate.
abstract: In the field of regenerative medicine, nanoscale physical cuing is clearly becoming a compelling determinant of cell behavior. Developing effective methods for making nanostructured surfaces with well-defined physicochemical properties is thus mandatory for the rational design of functional biomaterials. Here, we demonstrate the versatility of simple chemical oxidative patterning to create unique nanotopographical surfaces that influence the behavior of various cell types, modulate the expression of key determinants of cell activity, and offer the potential of harnessing the power of stem cells. These findings promise to lead to a new generation of improved metal implants with intelligent surfaces that can control biological response at the site of healing.
authors.affiliation: Universite de Montreal, Montreal, Quebec H3C 3J7, Canada.
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Vetrone
authors.forename: Fabio
authors.initials: F
authors.lastname: Variola
authors.forename: Paulo
authors.initials: P
authors.lastname: Tambasco de Oliveira
authors.forename: Sylvia Francis
authors.initials: SF
authors.lastname: Zalzal
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Yi
authors.forename: Johannes
authors.initials: J
authors.lastname: Sam
authors.forename: Karina F
authors.initials: KF
authors.lastname: Bombonato-Prado
authors.forename: Andranik
authors.initials: A
authors.lastname: Sarkissian
authors.forename: Dmitrii F
authors.initials: DF
authors.lastname: Perepichka
authors.forename: James D
authors.initials: JD
authors.lastname: Wuest
authors.forename: Federico
authors.initials: F
authors.lastname: Rosei
authors.forename: Antonio
authors.initials: A
authors.lastname: Nanci
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006801:Humans; D008670:Metals / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D013499:Surface Properties
chemical_list: D008670:Metals