Granulocyte transfusion in children.
We describe a single institution experience with the use of granulocyte transfusion in children. This is a retrospective analysis of 45 collections of granulocyte units obtained by apheresis after priming with dexamethasone, infused into 17 children with severe neutropenic infections. Ten children survived the acute infection. Granulocyte transfusion is a useful adjunct to antimicrobials and growth factors in post chemotherapy neutropenic sepsis and is highly effective in children with chronic granulomatous disease and life threatening infections.
Raj
Revathi
R
Apollo Hospitals, Chennai, India. revaraj@yahoo.com
Kamath
Shrishu R
SR
Ranjit
Suchitra
S
Shankar
Nirmal
N
Lakshmanan
V
V
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006098:Granulocytes; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D017708:Leukocyte Transfusion / Q000379:methods / Q000401:mortality*; D008297:Male; D009503:Neutropenia / Q000209:etiology / Q000401:mortality* / Q000628:therapy*; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood / Q000150:complications / Q000401:mortality; D016896:Treatment Outcome