title: Pull-out strength of multifunctional bioabsorbable ciprofloxacin-releasing polylactide-polyglycolide 80/20 tacks: an experimental study allograft cranial bone.
abstract: In this study, the pull-out forces of recently developed multifunctional bioabsorbable self-reinforced ciprofloxacin-releasing polylactide/polyglycolide (SR-PLGA+AB) 80/20 tacks were compared with plain SR-PLGA 80/20 tacks in human cadaver parietal bones. Pieces of parietal bone (approximately 6 x 20 cm) were harvested from 5 human cadavers (all were male, 29-77 years old). Fifty plain SR-PLGA tacks (diameter, 2.0 mm; length, 6.0 mm) and 50 ciprofloxacin-releasing SR-PLGA tacks of similar dimensions were applied to drill holes using a special tack shooter without tapping the drill holes. The force needed to pull the tacks from human parietal cadaver bones was measured using a universal tensile-testing machine, by tack pull-out speed of 10 mm/min. Means and SDs were calculated and analyzed using Student's t-test (SPSS version 10.0 for Windows). The pull-out forces of the ciprofloxacin-releasing and plain tacks were 147.0 +/- 5.94 and 141.4 +/- 8.97 N respectively (P = 0.14, statistically insignificant difference between the 2 groups). The cause of failure in all cases was barb breakage. Ciprofloxacin-releasing SR-PLGA 80/20 tacks seem to have a similar holding power to cranial bone as plain SR-PLGA (80/20) tacks but have additional advantage of ciprofloxacin release.
authors.affiliation: Department of Surgery, Oulu University Hospital, Oulu, Finland.
authors.forename: Johanna
authors.initials: J
authors.lastname: Tiainen
authors.forename: Kaisa
authors.initials: K
authors.lastname: Knuutila
authors.forename: Minna
authors.initials: M
authors.lastname: Veiranto
authors.forename: Esa
authors.initials: E
authors.lastname: Suokas
authors.forename: Pertti
authors.initials: P
authors.lastname: Törmälä
authors.forename: Outi
authors.initials: O
authors.lastname: Kaarela
authors.forename: Satu
authors.initials: S
authors.lastname: Länsman
authors.forename: Nureddin
authors.initials: N
authors.lastname: Ashammakhi
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D001858:Bone Nails; D002102:Cadaver; D002939:Ciprofloxacin / Q000737:chemistry*; D004058:Diffusion; D004867:Equipment Design; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008297:Male; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010294:Parietal Bone / Q000601:surgery*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013314:Stress, Mechanical; D013499:Surface Properties; D013718:Tensile Strength
chemical_list: D000890:Anti-Infective Agents; D001672:Biocompatible Materials; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002939:Ciprofloxacin