A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia.
Infants diagnosed with acute myelogenous leukemia (AML) are likely to have subtypes M4 or M5 characterized by 11q23 abnormalities like a t(9;11)(p22;q23). Detection of all possible types of chromosomal abnormalities, including mixed lineage leukemia (MLL) gene rearrangements at 11q23, is of importance for the identification of biological subgroups, which might differ in drug resistance and/or clinical outcome. Here, we report the clinical, conventional banding and molecular cytogenetics data of a 6-month-old boy with an AML-M5 presenting with a unique cryptic rearrangement involving the MLL gene: a three-way t(9;19;11)(p11.2;p13.1;q23).
de Jesus Marques-Salles
Terezinha
T
Genetic Department of University Federal of Pernambuco, Av. Prof. Moraes Rego, 1235-Cidade Universitária, Recife-PE-CEP: 50670-901 Brasil. tjmsalles@uol.com.br
Liehr
Thomas
T
Mkrtchyan
Hasmik
H
Raimondi
Susana C
SC
Tavares de Souza
Mariana
M
de Figueiredo
Amanda Faria
AF
Rouxinol
Soraia
S
Jordy Macedo
Fernanda C
FC
Abdelhay
Eliana
E
Santos
Neide
N
Macedo Silva
Maria Luiza
ML
D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
D051788:Myeloid-Lymphoid Leukemia Protein