title: [Effect of fenghuaqianqingcha on experimentally induced prostatic hyperplasia in mice].
abstract: OBJECTIVE
  To investigate the improvement of fenghuaqianqingcha (FQC) on Benign prostatic hyperplasia (BPH) in mice and the related mechanism.
  
  
  METHODS
  The BPH model was established by subcutaneous injection of testosterone propionate in mice. At the same time, mice were infused into the stomach with FQC in different dosages for three weeks. The mice were sacrificed later, and the prostate index, prostatic wet weight, testosterone levels in plasma and MDA contents, NO levels, GSH levels, as well as oxygen radical absorbance capacity (ORAC) values in prostate were measured and the morphological change of prostatic gland was observed by light microscope to observe the effects of FQC on BPH in mice. And the effect of FQC on 5 alpha-reductase was determinated in vitro by HPLC.
  
  
  RESULTS
  Compared with the BPH model group, all parameters including prostatic index, prostatic wet weight, T levels, MDA contents, ORAC values et. in different experimental groups showed significantly improvement after treatment with FQC. And FQC could inhibit the activity of 5alpha-reductase in vitro significantly.
  
  
  CONCLUSIONS
  FQC has antagonistic effect on BPH induced by testosterone propionate in mice, which may involve its inhibition of the activity of 5 alpha-reductase and accommodate the peroxidation condition.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural products, Jinan University, Guangzhou 510632, China. raoxiang@yeah.net
authors.forename: Xiang
authors.initials: X
authors.lastname: Rao
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Xia
authors.initials: X
authors.lastname: Feng
authors.forename: Nan
authors.initials: N
authors.lastname: Yao
authors.forename: Guo
authors.initials: G
authors.lastname: Xie
authors.forename: Kurihara
authors.initials: K
authors.lastname: Hiroshi
mesh_terms: D000818:Animals; D042944:Cholestenone 5 alpha-Reductase / Q000378:metabolism*; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011058:Pollen; D011467:Prostate / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D043343:Testosterone Propionate
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013739:Testosterone; D008315:Malondialdehyde; D042944:Cholestenone 5 alpha-Reductase; D005978:Glutathione; D043343:Testosterone Propionate