[The association of the SNAP-25 gene polymorphism with verbal memory and attention in patients with major psychosis and healthy people].
The synaptosomal-associated protein (SNAP-25) plays an integral role in synaptic transmission and in memory consolidation in the hippocampus. Recently an association between SNAP-25 gene polymorphism and cognitive ability has been reported in two independent studies of healthy people and patients with schizophrenia. Authors carried out an association study of MnlI SNAP-25 polymorphism and performance on neurocognitive tests measuring verbal memory, attention/executive functions in 66 patients with major psychosis, 75 their relatives and 136 controls. MANCOVA revealed a significant effect of group (small er, Cyrillic=0,00001) and genotype (small er, Cyrillic=0,012) as well as an interaction effect between group and genotype (small er, Cyrillic=0,02) on the performance on neurocognitive tests. Carriers of the TT genotype performed worse on the most tasks compared to other genotypes. The similar character of the MnlI SNAP-25 polymorphism effect on the variability of neurocognitive traits in all groups suggests the relationship between this gene and general cognitive ability.
Golimbet
V E
VE
Alfimova
M V
MV
Gritsenko
I K
IK
Lezheĭko
T V
TV
Lavrushina
O M
OM
Abramova
L I
LI
Kaleda
V G
VG
Barkhatova
A N
AN
Sokolov
A V
AV
Ebshteĭn
R P
RP
D000328:Adult; D001288:Attention / Q000502:physiology*; D004247:DNA / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D011618:Psychotic Disorders / Q000097:blood / Q000235:genetics* / Q000503:physiopathology; D050825:Synaptosomal-Associated Protein 25 / Q000097:blood / Q000235:genetics*; D014706:Verbal Learning / Q000502:physiology*; D055815:Young Adult
D050825:Synaptosomal-Associated Protein 25; D004247:DNA