title: Concurrent findings of achalasia and duodenal duplication in a Down syndrome patient.
abstract: The association between Down syndrome and gastrointestinal anomalies such as duodenal and esophageal atresia, tracheoesophageal fistulas, and Hirschsprung's disease is well documented. More recently, an association between Down syndrome and achalasia was reported. In this report, we describe a 48-year-old woman with a history of Down syndrome who presented with dysphagia. Work-up of the dysphagia showed not only achalasia but also a duodenal duplication. To our knowledge, there have been no reports of Down syndrome associated with duodenal duplication. Whether this finding is simply a coincidence or whether duodenal duplication is associated with Down syndrome will need to be determined with future studies.
authors.affiliation: Division of Gastroenterology, GI Motility Center, Cedars-Sinai Medical Center, Los Angeles, California, USA. gcchen@mednet.ucla.edu
authors.forename: Gary C
authors.initials: GC
authors.lastname: Chen
authors.forename: Derek W
authors.initials: DW
authors.lastname: Cheng
authors.forename: Pedram J
authors.initials: PJ
authors.lastname: Enayati
authors.forename: George
authors.initials: G
authors.lastname: Chen
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Conklin
authors.forename: Edy E
authors.initials: EE
authors.lastname: Soffer
mesh_terms: D003680:Deglutition Disorders / Q000150:complications* / Q000175:diagnosis; D003937:Diagnosis, Differential; D004314:Down Syndrome / Q000150:complications* / Q000175:diagnosis; D004386:Duodenum / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery; D004931:Esophageal Achalasia / Q000150:complications* / Q000175:diagnosis; D005260:Female; D018662:Fundoplication / Q000379:methods; D006801:Humans; D008365:Manometry / Q000009:adverse effects; D008875:Middle Aged; D016896:Treatment Outcome