title: Exploring the C-H...O interactions in glycoproteins.
abstract: Glycoproteins are an important class of proteins that play a significant role in many cellular events. In the present study, we analyze the influence of C-H...O interactions in relation to other environmental preferences in glycoproteins. CH...O interactions are now accepted as a genuine hydrogen bond. Main chain-main chain interactions are predominant. Proline residues stabilize strands by C-H...O interactions in glycoproteins. Majority of the C-H...O interacting residues were conserved and had one or more stabilization centers. CH...O interactions might be responsible for the global conformational stability, since long-range CH...O contacts were predominant. The results presented in this study might be useful for structural stability studies in glycoproteins.
authors.affiliation: Bioinformatics & Computational Biology Division, School of Biotechnology, Chemical & Biomedical Engineering, Vellore Institute of Technology, Vellore 632014, India.
authors.forename: Sudha
authors.initials: S
authors.lastname: Anand
authors.forename: Anand
authors.initials: A
authors.lastname: Anbarasu
authors.forename: Rao
authors.initials: R
authors.lastname: Sethumadhavan
mesh_terms: D001665:Binding Sites; D002244:Carbon / Q000737:chemistry*; D003198:Computer Simulation; D006023:Glycoproteins / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D006860:Hydrogen Bonding; D008956:Models, Chemical; D010100:Oxygen / Q000737:chemistry*; D011485:Protein Binding
chemical_list: D006023:Glycoproteins; D002244:Carbon; D006859:Hydrogen; D010100:Oxygen