Perspectives on NMR in drug discovery: a technique comes of age.
In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.
Pellecchia
Maurizio
M
Burnham Institute for Medical Research, La Jolla, California 92037, USA. mpellecchia@burnham.org
Bertini
Ivano
I
Cowburn
David
D
Dalvit
Claudio
C
Giralt
Ernest
E
Jahnke
Wolfgang
W
James
Thomas L
TL
Homans
Steve W
SW
Kessler
Horst
H
Luchinat
Claudio
C
Meyer
Bernd
B
Oschkinat
Hartmut
H
Peng
Jeff
J
Schwalbe
Harald
H
Siegal
Gregg
G
D016503:Drug Delivery Systems; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004345:Drug Industry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*