title: The surface modification of hydroxyapatite nanoparticles by the ring opening polymerization of gamma-benzyl-l-glutamate N-carboxyanhydride.
abstract: The surface modification of hydroxyapatite (HA) nanoparticles by the ring opening polymerization (ROP) of gamma-benzyl-L-glutamate N-carboxyanhydride (BLG-NCA) was proposed to prepare the poly(gamma-benzyl-L-glutamate) (PBLG)-grafted HA nanoparticles (PBLG-g-HA) for the first time. HA nanoparticles were firstly treated by 3-aminopropylthriethoxysilane (APS) and then the terminal amino groups of the modified HA particles initiated the ROP of BLG-NCA to obtain PBLG-g-HA. The process was monitored by XPS and FT-IR. The surface grafting amounts of PBLG on HA ranging from 12.1 to 43.1% were characterized by thermal gravimetric analysis (TGA). The powder X-ray diffraction (XRD) analysis confirmed that the ROP only underwent on the surface of HA nanoparticles without changing its bulk properties. The SEM measurement showed that the PBLG-g-HA hybrid could form an interpenetrating net structure in the self-assembly process. The PBLG-g-HA hybrid could maintain higher colloid stability than the pure HA nanoparticles. The in vitro cell cultures suggested the cell adhesion ability of PBLG-g-HA was much higher than that of pure HA.
authors.affiliation: State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
authors.forename: Junchao
authors.initials: J
authors.lastname: Wei
authors.forename: Aixue
authors.initials: A
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Chen
authors.forename: Peibiao
authors.initials: P
authors.lastname: Zhang
authors.forename: Xuesi
authors.initials: X
authors.lastname: Chen
authors.forename: Xiabin
authors.initials: X
authors.lastname: Jing
mesh_terms: D000812:Anhydrides / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D008422:Materials Testing; D053758:Nanoparticles / Q000737:chemistry*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D013052:Spectrometry, X-Ray Emission; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D000812:Anhydrides; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D017886:Durapatite