title: Clinical course of classic Kaposi's sarcoma in HIV-negative patients treated with the HIV protease inhibitor indinavir.
abstract: HIV protease inhibitors have been shown to exert antiangiogenic and antitumor actions independently from their antiretroviral effect. Based on these studies, HIV-seronegative patients with classic Kaposi's sarcoma were treated with indinavir and followed for clinical evolution, drug pharmacokinetics and Kaposi's sarcoma biomarkers. A favorable clinical course was associated with high drug plasma levels, reduced production of basic fibroblast growth factor, lower numbers of circulating endothelial cells, and a decrease in antibody titers against human herpesvirus 8.
authors.affiliation: National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Monini
authors.forename: Cecilia
authors.initials: C
authors.lastname: Sgadari
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Grosso
authors.forename: Stefania
authors.initials: S
authors.lastname: Bellino
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Biagio
authors.forename: Elena
authors.initials: E
authors.lastname: Toschi
authors.forename: Ilaria
authors.initials: I
authors.lastname: Bacigalupo
authors.forename: Michela
authors.initials: M
authors.lastname: Sabbatucci
authors.forename: Giulia
authors.initials: G
authors.lastname: Cencioni
authors.forename: Emanuela
authors.initials: E
authors.lastname: Salvi
authors.forename: Patrizia
authors.initials: P
authors.lastname: Leone
authors.forename: Barbara
authors.initials: B
authors.lastname: Ensoli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D000970:Antineoplastic Agents / Q000097:blood / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood; D017320:HIV Protease Inhibitors / Q000097:blood / Q000627:therapeutic use*; D018023:HIV Seronegativity; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D019469:Indinavir / Q000097:blood / Q000627:therapeutic use*; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000097:blood / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000914:Antibodies, Viral; D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D017320:HIV Protease Inhibitors; D019469:Indinavir