title: [Severe tubulo-interstitial nephritis secondary to 5-ASA].
abstract: We report a new case of chronic interstitial nephritis in a patient with ulcerative colitis diagnosed in 2002 who was originally treated with 5-ASA. Three years later deterioration of renal function was apparent with an increase in serum creatinine, which was normal before treatment. Withdrawal of 5-ASA led to partial improvement of renal function. In patients with a delayed diagnosis of kidney damage, recovery of renal function is incomplete and, in some cases, the patient even requires some form of renal replacement therapy. We stress the importance of monitoring renal function in patients diagnosed with inflammatory bowel disease treated with this drug.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Universitario Son Dureta, Palma de Mallorca, España. mjbosque@hsd.es
authors.forename: M José
authors.initials: MJ
authors.lastname: Bosque López
authors.forename: Carmen
authors.initials: C
authors.lastname: Garrido Durán
authors.forename: Daniel
authors.initials: D
authors.lastname: Ginard Vicens
authors.forename: M Antonia
authors.initials: MA
authors.lastname: Munar Vila
authors.forename: Margalida
authors.initials: M
authors.lastname: Vanrell Garau
authors.forename: Zoe
authors.initials: Z
authors.lastname: Mariño Méndez
authors.forename: Jaime
authors.initials: J
authors.lastname: Gayà Cantallops
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications / Q000188:drug therapy; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000628:therapy; D019804:Mesalamine / Q000009:adverse effects* / Q000627:therapeutic use; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D010531:Peritoneal Dialysis, Continuous Ambulatory
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine