Low-fat oxidation may be a factor in obesity among men with schizophrenia.
OBJECTIVE
Obesity associated with atypical antipsychotic medications is an important clinical issue for people with schizophrenia. The purpose of this project was to determine whether there were any differences in resting energy expenditure (REE) and respiratory quotient (RQ) between men with schizophrenia and controls.


METHODS
Thirty-one men with schizophrenia were individually matched for age and relative body weight with healthy, sedentary controls. Deuterium dilution was used to determine total body water and subsequently fat-free mass (FFM). Indirect calorimetry using a Deltatrac metabolic cart was used to determine REE and RQ.


RESULTS
When corrected for FFM, there was no significant difference in REE between the groups. However, fasting RQ was significantly higher in the men with schizophrenia than the controls.


CONCLUSIONS
Men with schizophrenia oxidised proportionally less fat and more carbohydrate under resting conditions than healthy controls. These differences in substrate utilisation at rest may be an important consideration in obesity in this clinical group.
Sharpe
J-K
JK
The Park-Centre for Mental Health, Treatment, Research and Education, Sumner Park BC, Qld, Australia. jenny-kay_sharpe@health.qld.gov.au
Stedman
T J
TJ
Byrne
N M
NM
Hills
A P
AP
D000273:Adipose Tissue / Q000378:metabolism*; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001823:Body Composition; D015992:Body Mass Index; D001834:Body Water / Q000378:metabolism; D002153:Calorimetry, Indirect; D050260:Carbohydrate Metabolism; D003903:Deuterium / Q000378:metabolism; D004734:Energy Metabolism; D005215:Fasting; D006801:Humans; D008297:Male; D008954:Models, Biological; D009765:Obesity / Q000139:chemically induced / Q000378:metabolism*; D010084:Oxidation-Reduction; D012146:Rest; D012559:Schizophrenia / Q000188:drug therapy / Q000378:metabolism*
D014150:Antipsychotic Agents; D003903:Deuterium