title: Obstetric outcomes of women with intracranial neoplasms.
abstract: OBJECTIVE
  To determine the obstetric outcomes of women diagnosed with a primary intracranial neoplasm prior to or during pregnancy and the puerperium.
  
  
  METHODS
  Demographic data, neurologic, obstetric, and neonatal outcomes were extracted retrospectively from charts identified from two hospital databases.
  
  
  RESULTS
  Twenty-two patients with 25 pregnancies were identified. Thirteen patients were diagnosed prior to pregnancy (group 1); tumor growth or recurrence during pregnancy occurred in 3 patients. Nine patients were diagnosed during pregnancy and the puerperium (group 2); 7 underwent neurosurgery at a mean gestational age of 27+/-5.7 weeks; 2 experienced permanent visual loss. Significantly more gliomas occurred in group 1, but there were significantly more meningiomas in group 2. Numbers of cesarean delivery, preterm delivery at less than 34 weeks, and NICU admission were higher in group 2 than group 1, but this was not statistically significant.
  
  
  CONCLUSIONS
  Although not statistically significant, neurologic deterioration during pregnancy may be associated with cesarean delivery, preterm delivery, and NICU admission.
authors.affiliation: Division of Maternal-Fetal Medicine, Mount Sinai Hospital, Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada. nadinej@cwjamaica.com
authors.forename: Nadine
authors.initials: N
authors.lastname: Johnson
authors.forename: Mathew
authors.initials: M
authors.lastname: Sermer
authors.forename: Andrea
authors.initials: A
authors.lastname: Lausman
authors.forename: Cynthia
authors.initials: C
authors.lastname: Maxwell
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D002585:Cesarean Section / Q000706:statistics & numerical data; D016208:Databases, Factual; D005260:Female; D005910:Glioma / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D008579:Meningioma / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009864:Ontario / Q000453:epidemiology; D049590:Postpartum Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000503:physiopathology*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology; D012189:Retrospective Studies; D014786:Vision Disorders / Q000453:epidemiology / Q000209:etiology