title: Sensitivity and specificity of oral brush biopsy.
abstract: The aim of this study was to evaluate the advantage of computer-assisted analysis of the oral brush biopsy compared with synchronous scalpel biopsy in the early detection of oral lesions. In this prospective, randomized, controlled study, brush and scalpel biopsies were performed on 75 patients. Six patients had to be excluded due to inadequate results, and 43 were shown to have dysplastic epithelium, 15 carcinoma, and 11 suspicious lesions. Therefore, the sensitivity for the detection of abnormal cells by means of OralCDx was 52%, specificity 29%, and the positive predictive value 63%. According to our results, the use of oral brush biopsy as a standardized, minimally invasive method of screening oral lesions should be reconsidered.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar, Technische Universitat München, Munich, Germany. majert@mkg.med.tum.de
authors.forename: Bettina
authors.initials: B
authors.lastname: Hohlweg-Majert
authors.forename: Herbert
authors.initials: H
authors.lastname: Deppe
authors.forename: Marc C
authors.initials: MC
authors.lastname: Metzger
authors.forename: Silja
authors.initials: S
authors.lastname: Schumm
authors.forename: Heinz
authors.initials: H
authors.lastname: Hoefler
authors.forename: Marco R
authors.initials: MR
authors.lastname: Kesting
authors.forename: Frank
authors.initials: F
authors.lastname: Hölzle
authors.forename: Klaus-Dietrich
authors.initials: KD
authors.lastname: Wolff
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods*; D003936:Diagnosis, Computer-Assisted; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D011446:Prospective Studies; D012680:Sensitivity and Specificity