Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma.
Clear-cell changes are rare in histological specimens of the dermis and raise complex diagnostic considerations regarding lineage differentiation (e.g., epithelial, mesenchymal, or melanocytic). We present a clear-cell atypical fibroxanthoma (CCAFX) and describe the morphological and immunohistochemical aspects of this rare skin lesion. Furthermore, we give an overview of the differential diagnoses of clear-cell lesions of the skin for a practical approach.
Kemmerling
Ralf
R
Department of Pathology, University Hospital Salzburg of the Paracelsus Private Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.
Dietze
Otto
O
Müller
Susanna
S
Neureiter
Daniel
D
D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009666:Nose / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D014408:Biomarkers, Tumor