Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.
Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries.
Jayanth
Thiruvellore Thatai
TT
Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.
Zhang
Lei
L
Johnson
Thomas S
TS
Malinakova
Helena C
HC
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
D000480:Alkynes; D006846:Hydrocarbons, Halogenated; D007097:Imines; D007192:Indenes; D007546:Isoquinolines; D017971:Tin Compounds; D014753:Vinyl Compounds; C031525:stannane; D010165:Palladium; D003300:Copper