title: Aspects of the differential diagnosis of clear-cell lesions of the skin in connection with the rare case of a clear-cell atypical fibroxanthoma.
abstract: Clear-cell changes are rare in histological specimens of the dermis and raise complex diagnostic considerations regarding lineage differentiation (e.g., epithelial, mesenchymal, or melanocytic). We present a clear-cell atypical fibroxanthoma (CCAFX) and describe the morphological and immunohistochemical aspects of this rare skin lesion. Furthermore, we give an overview of the differential diagnoses of clear-cell lesions of the skin for a practical approach.
authors.affiliation: Department of Pathology, University Hospital Salzburg of the Paracelsus Private Medical University, Müllner Hauptstr. 48, A-5020 Salzburg, Austria.
authors.forename: Ralf
authors.initials: R
authors.lastname: Kemmerling
authors.forename: Otto
authors.initials: O
authors.lastname: Dietze
authors.forename: Susanna
authors.initials: S
authors.lastname: Müller
authors.forename: Daniel
authors.initials: D
authors.lastname: Neureiter
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009666:Nose / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor