Effect of soluble fiber pectin on growth and intestinal iron absorption in rats during recovery from iron deficiency anemia.
The objective of this study was to verify whether soluble fiber pectin interferes in growth and intestinal iron absorption in rats during iron deficiency anemia recovery. Twenty-one-day-old Wistar rats (n = 48) were fed for 2 weeks on a diet without iron in order to induce iron deficiency anemia. The anemic animals (age = 36 days) were divided into two groups: (1) pectin, 50 g of pectin per kilogram of diet, and (2) control, diet without dietary fiber. Iron was added to the diets for the two groups in order to reverse the anemia. During the iron deficiency anemia recovery phase (3 weeks), the pectin group showed lower mean values (p < 0.05) of weekly food intake (89.18 +/- 10.82; 107.60 +/- 11.70; 114.50 +/- 16.29 g, respectively, for the pectin group and 99.56 +/- 10.60; 116.36 +/- 15.33; 125.66 +/- 17.25 g, respectively, for the control group). The body weight of the pectin group was lower (p < 0.05) during the study's second and third weeks (192.42 +/- 16.67 and 228.75 +/- 19.81 g, respectively, and 202.87 +/- 19.96 and 243.51 +/- 20.44 g for the control group). Pectin led to a reduction in food intake and growth but not to iron absorption when taking into account the regeneration of hemoglobin mass.
Feltrin
Carolina
C
Pediatric Gastroenterology Division, Nutrition Program of the Federal University of São Paulo-Paulista School of Medicine, Rua Pedro de Toledo 441, São Paulo, Brazil.
Batista de Morais
Mauro
M
de Cássia Freitas
Karine
K
Beninga de Morais
Tânia
T
Fagundes Neto
Ulysses
U
Silvério Amancio
Olga Maria
OM
D018798:Anemia, Iron-Deficiency / Q000188:drug therapy* / Q000378:metabolism*; D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007408:Intestinal Absorption / Q000187:drug effects* / Q000502:physiology; D019266:Iron, Dietary / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use*; D008297:Male; D010368:Pectins / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility
D019266:Iron, Dietary; D010368:Pectins