An antiplasmodial new (bis)indole alkaloid from the hard coral Tubastraea sp.
Tubastarea sp., a stony coral (Dendrophylliidae) from the Great Hanish in the Archipelago of the Hanish Islands, Yemen, contains, in addition to the known aplysinopsin (1) and 6-bromo-3'-deimino-3'-oxoaplysinopsin (2), the new bis(indole) alkaloid (3). The structures of compounds (1-3) were elucidated by interpretation of spectral data. Compound 3 inhibits the growth of Plasmodium falciparum (chloroquine-resistant strain) with an IC(50) 1.2 microg mL(-1).
Meyer
Michèle
M
Laboratoire de Chimie, Associé au CNRS, USM 502, MNHN, Paris. meyer@mnhn.fr
Delberghe
Florence
F
Liron
Frédéric
F
Guillaume
Mireille
M
Valentin
Alexis
A
Guyot
Michèle
M
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development; D013056:Spectrophotometry, Ultraviolet; D015006:Yemen
D000962:Antimalarials; D026121:Indole Alkaloids