Acetylcholinesterase-inhibiting activity of pyrrole derivatives from a novel marine gliding bacterium, Rapidithrix thailandica.
Acetylcholinesterase-inhibiting activity of marinoquinoline A (1), a new pyrroloquinoline from a novel species of a marine gliding bacterium Rapidithrix thailandica, was assessed (IC(50) 4.9 microM). Two related pyrrole derivatives, 3-(2'-aminophenyl)-pyrrole (3) and 2,2-dimethyl-pyrrolo-1,2-dihydroquinoline (4), were also isolated from two other strains of R. thailandica. The isolation of 3 from a natural source is reported here for the first time. Compound 4 was proposed to be an isolation artifact derived from 3. The two isolated compounds were virtually inactive in the acetylcholinesterase-inhibitory assay (enzyme inhibition < 30% at 0.1 g L(-1)).
Sangnoi
Yutthapong
Y
Department of Industrial Biotechnology, Faculty of Agro-Industry, Prince of Songkla University, Hat-Yai, Songkla 90112, Thailand.
Sakulkeo
Oraphan
O
Yuenyongsawad
Supreeya
S
Kanjana-opas
Akkharawit
A
Ingkaninan
Kornkanok
K
Plubrukarn
Anuchit
A
Suwanborirux
Khanit
K
D000110:Acetylcholinesterase / Q000187:drug effects* / Q000378:metabolism; D041963:Bacteroidetes / Q000737:chemistry; D045744:Cell Line, Tumor; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D011758:Pyrroles / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D011804:Quinolines / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D011758:Pyrroles; D011804:Quinolines; D000110:Acetylcholinesterase