Technical aspects of imaging and transfemoral arterial treatment of N1-S1 tumors in rats: an appropriate model to test the biology and therapeutic response to transarterial treatments of liver cancers.
The present study was undertaken to assess the technical feasibility of transfemoral hepatic artery catheterization in rats and to describe the imaging techniques that can be used on tumors in rats. A total of 106 N1-S1 cells were inoculated into the left lobes of 74 rats. In 17, transfemoral angiography was attempted. Tumor volumes for 2 weeks before angiography were measured with magnetic resonance imaging in 40 animals. Tumors grew in 63 animals. Angiography was successful in 16 rats. Mean tumor volumes were 0.13 mL and 0.9 mL after 1 and 2 weeks, respectively. In conclusion, transfemoral hepatic artery catheterization is feasible in this animal model.
Ju
Shenghong
S
Department of Radiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
McLennan
Gordon
G
Bennett
Stacy L
SL
Liang
Yun
Y
Bonnac
Laurent
L
Pankiewicz
Krzysztof W
KW
Jayaram
Hiremagalur N
HN
D000792:Angiography / Q000379:methods*; D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000379:methods*; D005240:Feasibility Studies; D006499:Hepatic Artery / Q000601:surgery*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D051381:Rats; D016896:Treatment Outcome