[A case of intrahepatic gastrinoma].
The Zollinger-Ellison syndrome is due to an endocrine gastrin-secreting tumor, the gastrinoma. This tumor is often malignant and patients develop metastases in 25% of cases. The usual localizations of gastrinomas are at the head of the pancreas, the duodenal wall and the peripancreatic lymph nodes. Ectopic localizations, such as stomach, small bowel, gallbladder, liver or ovaries, are rare. We report the case of an intrahepatic gastrinoma, surgically treated by left hepatectomy. Upon review of scientific literature, we found 19 cases of intrahepatic gastrinoma. This diagnosis is always difficult to establish, even after a complete preoperative imaging and an extensive operative search for a possible primary tumor. The best evidence for diagnosis is the gastrinemia decreasing to a normal range after liver resection, and the absence of recurrence in long-term follow-up.
Denève
E
E
Service de chirurgie digestive II, hôpital Saint-Eloi, centre hospitalo-universitaire de Montpellier, avenue Bertin-Sans, 34295 Montpellier, France. eric.deneve@free.fr
Hamoui
M
M
Chalançon
A
A
Blanc
P -M
P-
Aufort
S
S
Fabre
J -M
J-
Nocca
D
D
D000328:Adult; D003937:Diagnosis, Differential; D015408:Gastrinoma / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D011859:Radiography; D016896:Treatment Outcome