title: A compact architecture for three-dimensional neural microelectrode arrays.
abstract: A new architecture is presented for achieving three-dimensional electronic interfaces to the nervous system using planar microfabricated two-dimensional arrays. This architecture overcomes many of the limitations of existing approaches and enables flexible electrode configurations with minimal overhead in size. A 64-channel (4x4x4) 3-D array using this architecture is demonstrated with sites on 100 microm centers, interfacing with a volume of tissue less than 0.1mm3. The 1mm2 footprint of the device is the smallest ever reported.
authors.affiliation: Center for Wireless Integrated MicroSystems, Department of Electrical Engineering and Computer Science, The University of Michigan, Ann Arbor, MI 48109, USA. geadara@umich.edu
authors.forename: Gayatri E
authors.initials: GE
authors.lastname: Perlin
authors.forename: Kensall D
authors.initials: KD
authors.lastname: Wise
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity