Studies on paclitaxel-loaded glyceryl monostearate nanoparticles.
Solid lipid nanoparticles (SLNs) of Paclitaxel were prepared by modified Hot homogenization method using Glyceryl monostearate (GMS). The SLNs were characterized for its physicochemical characteristics such as mean particle size, percentage entrapment efficiency and zeta potential, which were found to be 226 nm, 92.43% and -29.4 mV, respectively. The Transmission Electron Microscopy (TEM) studies showed that prepared SLNs were of spherical shape. The drug retarding efficiency of the lipid (GMS) was better in pH 7.4 compared to pH 3.5. The release profile showed a tendency to follow Higuchi diffusion pattern at pH 7.4 and Peppas-Korsenmeyer model at pH 3.5. Chemosensitivity assay carried out using B16F10 cell lines showed that anti-proliferative activity of Paclitaxel was not hindered due to encapsulation.
Shenoy
Vikram Subraya
VS
Centre for Post Graduate Studies and Research, New Drug Delivery Systems Laboratory, Pharmacy Department, M S University of Baroda, Fatehgunj, Vadodara, Gujarat, India.
Rajyaguru
Tushar Himmatlal
TH
Gude
Rajiv Phondu
RP
Murthy
Rayasa S Ramchandra
RS
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry*; D005989:Glycerides / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry; D008545:Melanoma / Q000188:drug therapy; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage* / Q000494:pharmacology; D010316:Particle Size
D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D005989:Glycerides; D008055:Lipids; C048159:glyceryl monostearate; D017239:Paclitaxel