In vitro fertilization is associated with an increased risk for preeclampsia.
OBJECTIVE
To assess the association of intrauterine insemination, in vitro fertilization (IVF) and ovulation induction with the risk of preeclampsia.


METHODS
We conducted a population based retrospective cohort study of pregnancies conceived by assisted reproductive technology (1357 exposure subjects, 5190 controls) based on 2005 Niday Perinatal Database for Ontario, Canada. All pregnancies conceived by assisted reproductive technology were identified as exposure group. Four controls were randomly matched for each exposure subject by maternal age, parity, plurality, and delivery hospital level and residence area. The risks for preeclampsia associated with intrauterine insemination, IVF, and ovulation induction were evaluated through conditional logistic regression models compared with their corresponding controls.


RESULTS
With adjustment of maternal age, smoking during pregnancy and initiating time of prenatal care, in vitro fertilization was associated with an increased risk for preeclampsia (OR=1.78, 95% CI: 1.05, 3.06), whereas intrauterine insemination (OR=2.44, 95% CI: 0.74, 8.06) and ovulation induction (OR=1.34, 95% CI: 0.31, 5.75) was not associated with the risk for preeclampsia.


CONCLUSIONS
There was a higher incidence of preeclampsia among pregnancies conceived by IVF, but no significant association was found in intrauterine insemination and ovulation induction.
Chen
Xi-Kuan
XK
OMNI Research Group, Clinical Epidemiology Program, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada.
Wen
Shi Wu
SW
Bottomley
Jim
J
Smith
Graeme N
GN
Leader
Arthur
A
Walker
Mark C
MC
D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006801:Humans; D007315:Insemination, Artificial / Q000009:adverse effects*; D010062:Ovulation Induction / Q000009:adverse effects*; D011225:Pre-Eclampsia / Q000209:etiology*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors