title: Structures of acetylated oleanane-type triterpene saponins, rarasaponins IV, V, and VI, and anti-hyperlipidemic constituents from the pericarps of Sapindus rarak.
abstract: The methanolic extract and its saponin fraction (methanol-eluted fraction) of the pericarps of Sapindus rarak DC. were found to suppress plasma triglyceride elevation in olive oil-treated mice. From the active fraction, three new acylated oleanane-type triterpene saponins, rarasaponins IV (1), V (2), and VI (3), were isolated. The structures of 1-3 were elucidated on the basis of chemical and spectroscopic evidence. The principle saponin constituents, hederagenin 3-O-alpha-L-arabinopyranosyl-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (4) and hederagenin 3-O-(3,4-di-O-acetyl-alpha-L-arabinopyranosyl)-(1-->3)-alpha-L-rhamnopyranosyl-(1-->2)-alpha-L-arabinopyranoside (5), showed inhibitory effects on plasma triglyceride elevation at a dose of 200 mg/kg, per os.
authors.affiliation: Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Japan.
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Asao
authors.forename: Toshio
authors.initials: T
authors.lastname: Morikawa
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Xie
authors.forename: Masaki
authors.initials: M
authors.lastname: Okamoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Hamao
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Osamu
authors.initials: O
authors.lastname: Muraoka
authors.forename: Dan
authors.initials: D
authors.lastname: Yuan
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000107:Acetylation; D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D015228:Hypertriglyceridemia / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000069463:Olive Oil; D024301:Plant Bark / Q000737:chemistry; D010938:Plant Oils; D032127:Sapindus / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet; D014280:Triglycerides / Q000097:blood; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000960:Hypolipidemic Agents; D000069463:Olive Oil; D010938:Plant Oils; D012503:Saponins; D014280:Triglycerides; D014315:Triterpenes; C539109:rarasaponin IV; C539107:rarasaponin V; C539108:rarasaponin VI; D009828:Oleanolic Acid