Successful treatment of cytomegalovirus polyradiculopathy in a 9-year-old child with congenital human immunodeficiency virus infection.
Cytomegalovirus lumbosacral polyradiculopathy is a well-documented complication of human immunodeficiency virus in adults who have a CD4 count of less than 40/microL. Patients present with an acute ascending flaccid paralysis of the lower limbs with areflexia, paresthesia, and urinary and bowel symptoms. However, it appears to be rare in children with congenitally acquired immune deficiency syndrome. We report a 9-year-old child with congenital human immunodeficiency virus infection who presented with cytomegalovirus polyradiculopathy and made an excellent response to cytomegalovirus treatment.
Sohal
Aman
A
Department of Neurology, Littlewoods Neuroscience Foundation, Royal Liverpool Children's NHS Trust, Alder Hey, Liverpool, United Kingdom.
Riordan
Andrew
A
Mallewa
Mac
M
Solomon
Tom
T
Kneen
Rachel
R
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology; D000998:Antiviral Agents / Q000627:therapeutic use*; D001921:Brain / Q000473:pathology; D002648:Child; D003586:Cytomegalovirus Infections / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D015658:HIV Infections / Q000151:congenital*; D006801:Humans; D008279:Magnetic Resonance Imaging; D011128:Polyradiculopathy / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D013131:Spine / Q000473:pathology; D016896:Treatment Outcome
D000998:Antiviral Agents; D017245:Foscarnet; D015774:Ganciclovir