Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral Lobophytum durum.
Chemical investigations of the soft coral Lobophytum durum have led to the isolation of three unprecedented hemiketal cembranolides, durumhemiketalolides A-C (1-3). Full NMR spectroscopic assignments are provided for all isolated metabolites. The anti-inflammatory activities of 1-3 were evaluated in vitro.
Cheng
Shi-Yie
SY
Department of Marine Biotechnology and Resources, National Sun Yat-sen UniVersity, Kaohsiung 804, Taiwan, Republic of China.
Wen
Zhi-Hong
ZH
Wang
Shang-Kwei
SK
Chiou
Shu-Fen
SF
Hsu
Chi-Hsin
CH
Dai
Chang-Feng
CF
Chiang
Michael Y
MY
Duh
Chang-Yih
CY
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects / Q000201:enzymology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D012477:Salmonella enteritidis / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; C535129:durumhemiketalolide A; C535130:durumhemiketalolide B; C535131:durumhemiketalolide C