title: Towards the total chemical synthesis of integral membrane proteins: a general method for the synthesis of hydrophobic peptide-thioester building blocks.
abstract: Modification of a peptide-(α)thioester with a sequence of six arginines on the thioester leaving group can render soluble all peptides derived from a polytopic integral membrane protein. This strategy greatly simplifies the synthesis of peptide-(α)thioester building blocks for the total chemical synthesis of integral membrane proteins by native chemical ligation.
authors.affiliation: Institute for Biophysical Dynamics, 929 E. 57 Street, Chicago, IL 60637, USA.
authors.forename: Erik C B
authors.initials: EC
authors.lastname: Johnson
authors.forename: Stephen B H
authors.initials: SB
authors.lastname: Kent