Molecular phylogenetics of nearly full-length HIV type 2 envelope gene sequences from West India.
Abstract While infection with HIV-1 has become a pandemic, the presence of HIV-2 is also of concern in certain regions of the world. We have characterized the gp105 region of the envelope gene of HIV-2 isolates from Western India. Phylogenetic analysis of all 18 sequences revealed that these sequences were closely related to each other as well as to published African and European HIV-2 group A sequences, with an overall genetic divergence of 10.9% (range 2-14%). Our study sequences showed close relatedness with West African HIV-2 group A (CAM group) sequences from Guinea Bissau with 89% homology. This was further confirmed by SimPlot as well as RIP analysis. Accordingly, the sequences presented here demonstrate the predominance of HIV-2 group A infection and show no evidence of HIV-2 recombination in Western India.
Jadhav
Sushama
S
National AIDS Research Institute (Indian Council of Medical Research), Bhosari, Pune 411 026, India.
Tripathy
Srikanth
S
Kulkarni
Smita
S
Agnihotri
Kalpana
K
Risbud
Arun
A
Paranjape
Ramesh
R
D000328:Adult; D016000:Cluster Analysis; D005260:Female; D015658:HIV Infections / Q000821:virology*; D015498:HIV-2 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
D054299:env Gene Products, Human Immunodeficiency Virus