Correlates and mediators of functional disability in obsessive-compulsive disorder.
BACKGROUND
This study examined factors associated with obsessive-compulsive disorder (OCD) related functional disability in 87 treatment-seeking adults with OCD.


METHODS
A trained evaluator administered the Yale-Brown Obsessive-Compulsive Scale and Brown Assessment of Beliefs Scale. Patients completed the Sheehan Disability Scale, Obsessive-Compulsive Inventory-Revised, Interpretation of Intrusions Inventory, Thought-Action Fusion Scale, Beck Depression Inventory Second Edition, and State Trait Anxiety Inventory-Trait Version.


RESULTS
Results indicated that OCD symptoms, anxiety, depression, and the tendency to misinterpret the significance of intrusive thoughts were related to functional disability. Two variables-depressive symptoms and the extent to which a patient attempts to resist and is able to control OCD symptoms-emerged as unique predictors of functional disability. Mediational analyses indicated that both of these variables fully mediated the relationship between OCD-related distress and functional disability.


CONCLUSIONS
Results are discussed in terms of predictors of functional disability in OCD and in terms of implications for assessment and treatment.
Storch
Eric A
EA
Department of Pediatrics, Psychiatry, and Psychology, University of South Florida, Box 7523, 800 6th Street South, St. Petersburg, FL 33701, USA. estorch@health.usf.edu
Abramowitz
Jonathan S
JS
Keeley
Mary
M
D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000523:psychology; D015897:Comorbidity; D003469:Culture; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis* / Q000523:psychology; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics