title: Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients.
abstract: Understanding the molecular factors that distinguish inflammatory breast cancer (IBC) from non-IBC is important for IBC diagnosis. We reviewed the records of 48 IBC patients and 64 non-IBC patients from Egypt. We determined RhoC expression and tumor emboli and their relationship to demographic and reproductive characteristics. Compared with non-IBC patients, IBC patients had significantly lower parity (P=0.018) and fewer palpable tumors (P<0.0001). IBC tumors showed RhoC overexpression more frequently than non-IBC tumors (87% vs. 17%, respectively) (P<0.0001). Tumor emboli were significantly more frequent in IBC tumors than non-IBC tumors (Mean+/- SD: 14.1+/-14.0 vs. 7.0+/-12.9, respectively) (P<0.0001). This study illustrates that RhoC overexpression and tumor emboli are more frequent in tumors of IBC relative to non-IBC from Egypt. Future studies should focus on relating epidemiologic factors to molecular features of IBC in this population.
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA.
authors.forename: An-Chi
authors.initials: AC
authors.lastname: Lo
authors.forename: Ageliki
authors.initials: A
authors.lastname: Georgopoulos
authors.forename: Celina G
authors.initials: CG
authors.lastname: Kleer
authors.forename: Mousumi
authors.initials: M
authors.lastname: Banerjee
authors.forename: Sherif
authors.initials: S
authors.lastname: Omar
authors.forename: Hussein
authors.initials: H
authors.lastname: Khaled
authors.forename: Saad
authors.initials: S
authors.lastname: Eissa
authors.forename: Ahmed
authors.initials: A
authors.lastname: Hablas
authors.forename: Hoda G
authors.initials: HG
authors.lastname: Omar
authors.forename: Julie A
authors.initials: JA
authors.lastname: Douglas
authors.forename: Sofia D
authors.initials: SD
authors.lastname: Merajver
authors.forename: Amr S
authors.initials: AS
authors.lastname: Soliman
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000235:genetics / Q000378:metabolism; D018275:Carcinoma, Lobular / Q000235:genetics / Q000378:metabolism; D004534:Egypt; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D017720:Molecular Epidemiology; D009360:Neoplastic Cells, Circulating; D010298:Parity; D011247:Pregnancy; D012189:Retrospective Studies; D020741:rho GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D000075024:rhoC GTP-Binding Protein
chemical_list: C066690:RHOC protein, human; D020741:rho GTP-Binding Proteins; D000075024:rhoC GTP-Binding Protein