Perinatal outcome of monoamniotic twin pregnancies.
OBJECTIVE
To study perinatal mortality and neonatal morbidity in a large cohort of monoamniotic twin pregnancies with special emphasis to the gestational age-specific mortality.


METHODS
The study included monoamniotic twin pregnancies delivered in 10 perinatal centers in the Netherlands between January 2000 and December 2007.


RESULTS
A total of 98 monoamniotic pregnancies were included. The perinatal mortality rate (20 weeks of gestation through 28 days of life) was 19%; after exclusion of fetuses with lethal anomalies, the rate was 17%. After 32 weeks of gestation, only two pregnancies were complicated by perinatal mortality (4%). The incidence of twin-twin transfusion syndrome was 6%. The incidence of congenital heart anomalies and cerebral injury was 4% and 5%, respectively.


CONCLUSIONS
The current incidence of perinatal mortality in monoamniotic twins is considerably lower than in previous decades, but it is still high and occurs throughout pregnancy.


METHODS
III.
Hack
Karien E
KE
Department of Obstetrics, Wilhelmina Children's Hospital, University Medical Centre Utrecht, Utrecht the Netherlands. k.e.a.hack@umcutrecht.nl
Derks
Jan B
JB
Schaap
Arty H
AH
Lopriore
Enrico
E
Elias
Sjoerd G
SG
Arabin
Birgit
B
Eggink
Alex J
AJ
Sollie
Krystyna M
KM
Mol
Ben Willem J
BW
Duvekot
Hans J
HJ
Willekes
Christine
C
Go
Attie T
AT
Koopman-Esseboom
Corine
C
Vandenbussche
Frank P
FP
Visser
Gerard H
GH
D000650:Amnion / Q000473:pathology; D015331:Cohort Studies; D004200:Diseases in Twins / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D005260:Female; D005313:Fetal Death / Q000453:epidemiology; D005330:Fetofetal Transfusion / Q000401:mortality; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D012189:Retrospective Studies; D014430:Twins, Monozygotic