title: A new 24-membered lactone and a new polyene delta-lactone from the marine bacterium Bacillus marinus.
abstract: A new 24-membered macrolide macrolactin T (1), and a new polyene delta-lactone macrolactin U (2), along with macrolactins A, B, D, O, and S, were isolated from the cultured broth of the bacterium Bacillus marinus, which was isolated from Suaeda salsa collected in the coastline of Bohai Sea of China. The structures of 1 and 2 were elucidated on the basis of extensive spectroscopic data analyses. The inhibitory activity of macrolactins T, B and D against fungi Pyricularia oryzae and Alternaria solani, and bacteria Staphylococcus aureus is reported.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, PR China.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Xue
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Minjuan
authors.initials: M
authors.lastname: Xu
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Deng
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000528:Alternaria / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001407:Bacillus / Q000737:chemistry* / Q000302:isolation & purification; D019663:Chenopodiaceae / Q000382:microbiology*; D002681:China; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020082:Magnaporthe / Q000187:drug effects; D015394:Molecular Structure; D011090:Polyenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013057:Spectrum Analysis; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007783:Lactones; D018942:Macrolides; D011090:Polyenes; C540751:macrolactin T; C540752:macrolactin U