title: Repeated dosing of digoxin-fragmented antibody in preterm eclampsia.
abstract: Early onset eclampsia has significant morbidity and mortality for both the mother and fetus. No effective treatment exists at present except delivery and seizure prophylaxis with magnesium sulfate. We report the novel use of a fragmented ovine antibody against digoxin for the treatment of eclampsia. A 16-year-old primagravida at 29 weeks 5/7 days gestation presented with clinical diagnosis of eclampsia and was treated with compassionate off-label use of digoxin-fragmented ovine antibody (Digibind Glaxo Smith Kline, Research Triangle Park, NC, USA). Improvement of her underlying disorder during a 48 h treatment window was noted without adverse maternal or neonatal outcome. We suggest digoxin-fragmented ovine antibody as a possible intervention in preterm pregnancies complicated by pre-eclampsia or eclampsia.
authors.affiliation: The Chattanooga Unit, Department of Obstetrics & Gynecology, The Section on Maternal-Fetal Medicine, The University of Tennessee College of Medicine, Chattanooga, TN 37403, USA. adair@rocob.com
authors.forename: C D
authors.initials: CD
authors.lastname: Adair
authors.forename: V M
authors.initials: VM
authors.lastname: Buckalew
authors.forename: J
authors.initials: J
authors.lastname: Kipikasa
authors.forename: C
authors.initials: C
authors.lastname: Torres
authors.forename: S P
authors.initials: SP
authors.lastname: Stallings
authors.forename: C M
authors.initials: CM
authors.lastname: Briery
mesh_terms: D000293:Adolescent; D000906:Antibodies / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D047928:Premature Birth
chemical_list: D000906:Antibodies; D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments