[Association of gene polymorphisms of cytokine and cytokine receptor with type III prostatitis].
OBJECTIVE
To explore the role of the gene polymorphism of cytokine and cytokine receptors in the pathogenesis of type III prostatitis.


METHODS
We genotyped 24 outpatients diagnosed with type III prostatitis and 51 healthy volunteer controls for the single nucleotide polymorphisms of 13 cytokines and cytokine receptors at 22 sites by Sequence Specific Primer -PCR (SSP-PCR).


RESULTS
The patients exhibited significantly higher frequencies of the genotypes of IL-10-819 T/T (62.5%) and IL-10-592 A/A (62.5%), the haplotype of IL-10 (-1082/-819/-592) ATA (75.0%) and the diploid genotype of IL-10 (-1082/-819/-592) ATA/ATA (62.5%), than with the healthy controls (31.3% , 31.3%, 25.0% and 31.2%) (P < 0. 05).


CONCLUSIONS
Our data suggested that anti-inflammation cytokine IL-10 gene polymorphisms were associated with the pathogenesis of type III prostatitis.
Peng
Feng-Hua
FH
Department of Urology, The Second Hospitial Affiliated to Xiangya Medical College, Central South University, Changsha, Hunan 410011, China. pfh3327@sina.com
Yang
Jin-Rui
JR
Peng
Long-Kai
LK
Xie
Xu-Biao
XB
D000328:Adult; D016022:Case-Control Studies; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D008297:Male; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011472:Prostatitis / Q000235:genetics*; D053701:Receptors, Interleukin-10 / Q000235:genetics*
D053701:Receptors, Interleukin-10; D016753:Interleukin-10