[Expression of cyclin A in childhood acute leukemia and its significance].
OBJECTIVE
To investigate the expression of cyclin A protein in childhood acute leukemia (AL) and its significance.


METHODS
By using Western blotting analysis, cyclin A protein in bone marrow mononuclear cells from 47 newly diagnosed AL children and 33 non-hematological malignancy children was detected.


RESULTS
The expression of cyclin A in AL group (0.38 +/- 0.20) was higher than that in control group (0.03 +/- 0.15) (P < 0.01). The expression of cyclin A in high risk acute lymphocyte leukemia (ALL) group (HR-ALL) (0.62 +/- 0.38) was higher than that in standard risk ALL group (SR-ALL) (0.33 +/- 0.33) (P < 0.05). The expression of cyclin A in WBC > or = 50 x 10(9)/L group and in WBC < 50 x 10(9)/L group was (0.64 +/- 0.36) and (0.39 +/- 0.38), respectively (P < 0.05). Eight (44.4%) out of 18 patients with positive cyclin A expression achieved complete remission (CR). The CR rate was lower than that of patients with negative cyclin A expression (100%) (P < 0.01).


CONCLUSIONS
The higher expression of cyclin A may predict a poor prognosis for childhood ALL.
Wang
Jun
J
Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Zhang
Yun-juan
YJ
Feng
Jian-fei
JF
Wang
Xi-Ge
XG
Deng
Cai-yan
CY
Tang
You-cai
YC
D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D019925:Cyclin A / Q000235:genetics / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000378:metabolism*; D008297:Male
D019925:Cyclin A