title: Restored cardiac conditions and left ventricular function after parathyroidectomy in a hemodialysis patient. Parathyroidectomy improves cardiac fatty acid metabolism assessed by 123I-BMIPP.
abstract: A 62 year-old female hemodialysis patient underwent parathyroidectomy to treat secondary hyperparathyroidism. On the preoperative assessment, the plasma levels of parathyroid hormone (PTH) and B-type natriuretic peptide (BNP) were elevated. Echocardiography showed reduced left ventricular (LV) contraction. Myocardial iodine-123-15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid ((123)I-BMIPP) scintigraphy showed moderately reduced tracer uptake in the postero-inferior area on single-photon emission computed tomography and decreased washout on the planar images. After parathyroidectomy, the plasma levels of PTH and BNP decreased, followed by improvement in LV contraction. Myocardial (123)I-BMIPP scintigraphy revealed that the washout on planar images had increased, which suggests that myocardial (123)I-BMIPP scintigraphy is useful for estimating the effect of parathyroidectomy on cardiac function.
authors.affiliation: Cardiovascular Center, Nagoya Daini Red Cross Hospital, Japan. nana@nagoya2.jrc.or.jp
authors.forename: Mamoru
authors.initials: M
authors.lastname: Nanasato
authors.forename: Norihiko
authors.initials: N
authors.lastname: Goto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Isobe
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Unno
authors.forename: Haruo
authors.initials: H
authors.lastname: Hirayama
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Sato
authors.forename: Susumu
authors.initials: S
authors.lastname: Matsuoka
authors.forename: Takaharu
authors.initials: T
authors.lastname: Nagasaka
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tominaga
authors.forename: Kazuharu
authors.initials: K
authors.lastname: Uchida
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000378:metabolism / Q000601:surgery*; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism / Q000628:therapy; D008875:Middle Aged; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D019275:Radiopharmaceuticals; D020127:Recovery of Function; D006435:Renal Dialysis; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D010281:Parathyroid Hormone; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; D020097:Natriuretic Peptide, Brain