Consistency of self-reported first-degree family history of cancer in a population-based study.
The aim of this study was to assess the prevalence and consistency of self-reported family history of cancer among first-degree relatives (FDR) in a population-based study. Women at primary care units (PCU) were submitted to a questionnaire about cancer family history. Consistency of the report was determined by comparing self-reported history at the PCU to data from subsequent genetic evaluations and/or cancer confirmatory documents. Consistency in relation to degree of education, reported tumor type and reported age at cancer diagnosis in FDR was assessed. In 8,881 women interviewed, the prevalence of cancer in an FDR was 25.14% (CI 95%: 24.14; 25.94). Mean age was 40.29 years and most (70.26%) had < or = 8 years of education. There was a good agreement of self-reported cancer history at the PCU and in subsequent genetic evaluations [Kappa coefficient = 0.76 (P < 0.05)]. Inconsistencies were not related to low literacy (chi (2) = 2.027; P = 0.363). Consistency of the reported information for cancer status, cancer type and age of onset was 92.59%, 85.33% and 92.64%, respectively. The prevalence of cancer history in an FDR was similar to previous reports in other populations. Consistency and reliability of the self-reported information was high, regardless of educational level.
Roth
Fernanda Lenara
FL
Postgraduate Program in Medicine: Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Camey
Suzi Alves
SA
Caleffi
Maira
M
Schuler-Faccini
Lavínia
L
Palmero
Edenir Inêz
EI
Bochi
Carla
C
Moreira
Susana Mayer
SM
Kalakun
Luciane
L
Giugliani
Roberto
R
Ashton-Prolla
Patrícia
P
D017668:Age of Onset; D001938:Brazil / Q000453:epidemiology; D001943:Breast Neoplasms / Q000235:genetics; D003111:Colonic Polyps / Q000235:genetics; D004252:DNA Mutational Analysis; D005190:Family; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008499:Medical Records; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D010375:Pedigree; D011159:Population Surveillance; D015995:Prevalence; D011471:Prostatic Neoplasms / Q000235:genetics; D012042:Registries; D014594:Uterine Neoplasms / Q000235:genetics