title: [Transsphenoidal resection of pituitary adenomas: long-term results from the Leiden University Medical Center].
abstract: OBJECTIVE
  To evaluate the long-term outcome of transsphenoidal resection of pituitary adenomas at the Leiden University Medical Center (LUMC), The Netherlands.
  
  
  METHODS
  Retrospective, descriptive.
  
  
  METHODS
  416 consecutive patients undergoing surgery for pituitary adenoma at the LUMC between 1978 and 2004 were included; 174 patients with non-functioning macroadenomas (NFMA), 164 patients with acromegaly and 78 patients with Cushing's disease.
  
  
  RESULTS
  Biochemical remission was achieved in 66% of patients with acromegaly, and 72% of patients with Cushing's disease; incidence of pituitary failure was low in these patients (5% and 18% respectively). In 82% of the patients with NFMA visual function improved whereas the percentage with any degree of pituitary failure increased from 85% (preoperatively) to 95% (postoperatively). During follow-up of 10-15 years, the recurrence rate for acromegaly and Cushing's disease was 9% and for NFMA it was 15%.
  
  
  CONCLUSIONS
  Transsphenoidal resection is an effective treatment in most, but not all, patients with pituitary adenomas. The surgical results at the LUMC are comparable with those obtained in important international centres. All patients cured by surgery need lifelong follow-up, because of the real risk of recurrent disease.
authors.affiliation: Afd. Stofwisselingsziekten en Endocrinologie, Leids Universitair Medisch Centrum, Albinusdreef 2, 2333 AA Leiden. nrbiermasz@lumc.nl
authors.forename: N R
authors.initials: NR
authors.lastname: Biermasz
authors.forename: O M
authors.initials: OM
authors.lastname: Dekkers
authors.forename: J
authors.initials: J
authors.lastname: Voormolen
authors.forename: R J W
authors.initials: RJ
authors.lastname: de Keizer
authors.forename: K J
authors.initials: KJ
authors.lastname: Neelis
authors.forename: F T
authors.initials: FT
authors.lastname: Wiggers-de Bruïne
authors.forename: J W A
authors.initials: JW
authors.lastname: Smit
authors.forename: A M Pereira
authors.initials: AM
authors.lastname: Arias
authors.forename: J A
authors.initials: JA
authors.lastname: Romijn
mesh_terms: D000172:Acromegaly / Q000473:pathology / Q000601:surgery; D000236:Adenoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007016:Hypophysectomy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D047748:Pituitary ACTH Hypersecretion / Q000473:pathology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery*; D012074:Remission Induction; D012189:Retrospective Studies; D016896:Treatment Outcome