title: [Study on the drug resistance situation among recently infected HIV-1 patients in Dehong].
abstract: OBJECTIVE
  To study the HIV-1 drug resistance (DR) situation among newly infected persons in Dehong.
  
  
  METHODS
  1048 HIV-1 positive blood samples from July to December in 2006 from Dehong prefecture of Yunnan, were collected. HIV drug resistance were tested using TruGene in newly infected people that were distinguished with BED-CEIA, while the subtype were determined with phylogenetic analysis using a set of reference sequences available on the Los Alamos Database.
  
  
  RESULTS
  Of sixty-four successfully analyzed samples, drug resistance mutations were detected in 4 samples with the resistance rate as 6.25%. Minor mutation in PR region such as M361/V, L63P and H69K appeared frequently and the rates were 81.25%, 70.31% and 65.63% respectively. The predominantly prevalent strains were seen as C/CRF07 _ BC/08 _ BC(65.63%, 42/64) in this study.
  
  
  CONCLUSIONS
  The prevalence of genotypic drug resistances in HIV-1 recent infections in Dehong prefecture appeared to be at moderate level. Drug-resistance surveillance program among HIV-1 infections should be continued and strengthened.
authors.affiliation: Cancer Hospital & Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100027, China.
authors.forename: Min-Jie
authors.initials: MJ
authors.lastname: Wang
authors.forename: Song
authors.initials: S
authors.lastname: Duan
authors.forename: Li-Fen
authors.initials: LF
authors.lastname: Xiang
authors.forename: Yue-Cheng
authors.initials: YC
authors.lastname: Yang
authors.forename: Yuan-Quan
authors.initials: YQ
authors.lastname: Tu
authors.forename: Ji-Bao
authors.initials: JB
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Yao
authors.forename: Jun
authors.initials: J
authors.lastname: Qi
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology; D002681:China; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood
chemical_list: D019380:Anti-HIV Agents; D012367:RNA, Viral