title: Perspectives on NMR in drug discovery: a technique comes of age.
abstract: In the past decade, the potential of harnessing the ability of nuclear magnetic resonance (NMR) spectroscopy to monitor intermolecular interactions as a tool for drug discovery has been increasingly appreciated in academia and industry. In this Perspective, we highlight some of the major applications of NMR in drug discovery, focusing on hit and lead generation, and provide a critical analysis of its current and potential utility.
authors.affiliation: Burnham Institute for Medical Research, La Jolla, California 92037, USA. mpellecchia@burnham.org
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pellecchia
authors.forename: Ivano
authors.initials: I
authors.lastname: Bertini
authors.forename: David
authors.initials: D
authors.lastname: Cowburn
authors.forename: Claudio
authors.initials: C
authors.lastname: Dalvit
authors.forename: Ernest
authors.initials: E
authors.lastname: Giralt
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Jahnke
authors.forename: Thomas L
authors.initials: TL
authors.lastname: James
authors.forename: Steve W
authors.initials: SW
authors.lastname: Homans
authors.forename: Horst
authors.initials: H
authors.lastname: Kessler
authors.forename: Claudio
authors.initials: C
authors.lastname: Luchinat
authors.forename: Bernd
authors.initials: B
authors.lastname: Meyer
authors.forename: Hartmut
authors.initials: H
authors.lastname: Oschkinat
authors.forename: Jeff
authors.initials: J
authors.lastname: Peng
authors.forename: Harald
authors.initials: H
authors.lastname: Schwalbe
authors.forename: Gregg
authors.initials: G
authors.lastname: Siegal
mesh_terms: D016503:Drug Delivery Systems; D015195:Drug Design; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004345:Drug Industry; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*