[Effect of CDK2 on proliferation in laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the role of CDK2 in the development of DNA heteroploid in laryngeal squamous cell carcinoma (LSCC).


METHODS
Fifty specimens of LSCC, twelve specimens of atypical hyperplasia and thirty specimens of vocal cord polyp were obtain during operation. Centrosome were detected by anti tubulin antibodies. Immunohistochemical method was used to analyze the protein expression of CDK2 and gamma-tubulin.


RESULTS
The positive rate of CDK2 and gamma-tubulin in LSCC were 68.0% (34/50) and 78.0% (10/15), all of them were significant higher than those in the vocal cord polyp (P<0.05). Expression of CDK2 in LSCC was positively association with expression of gamma-tubulin.


CONCLUSIONS
This experiment indicated that overexpression of CDK2 was strongly correlated with abnormal proliferation in LSCC, and it may be a valuable marker for the diagnosis and therapy of LSCC.
Zhang
Haili
H
Department of Otolaryngology, the First Hospital of Medical University, Taiyuan, 030001, China. zhanghaili1975@yahoo.com.cn
Wang
Binquan
B
Liu
Rong
R
Wen
Shuxin
S
Huangfu
Hui
H
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D051357:Cyclin-Dependent Kinase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged
C495894:CDK2 protein, human; D051357:Cyclin-Dependent Kinase 2