title: Fixation of autogenous bone grafts with ethyl-cyanoacrylate glue or titanium screws in the calvaria of rabbits.
abstract: This study compared the fixation of autogenous onlay bone grafts with cyanoacrylate glue (Super Bonder) and with titanium screws. Twenty rabbits underwent bilateral parietal ostectomies. Bone segments were fixed anteriorly to the resulting bone defect. In group I, the grafts were fixed with 4 mm long, 1.5 mm diameter screws; in group II, adhesive was used. The animals were killed after 5, 15, 30, 60 and 120 days. Histomorphometric analysis was used to quantify the maintenance of the graft area. Discrete areas of inflammatory reaction were seen in both groups after 5 days and for group II after 15 days. After 30 days, new bone formation was seen at the interface of the grafts. After 120 days, the graft was incorporated into the host bed in group I and partially incorporated in group II. There was a significant statistical difference regarding the mean graft areas between 15 and 120 days (p<0.001) and between fixation methods (p<0.002). Fixation with adhesive promoted a significantly greater area of bone graft than screw fixation, independent of time period. The adhesive was biocompatible, presented similar stability to the screw and maintained the bone area, although there was a delay in graft incorporation.
authors.affiliation: Biochemistry and Chemical Technology Department, Institute of Chemistry at Araraquara, UNESP, Brazil.
authors.forename: S
authors.initials: S
authors.lastname: Saska
authors.forename: E
authors.initials: E
authors.lastname: Hochuli-Vieira
authors.forename: A M
authors.initials: AM
authors.lastname: Minarelli-Gaspar
authors.forename: M F R
authors.initials: MF
authors.lastname: Gabrielli
authors.forename: M V
authors.initials: MV
authors.lastname: Capela
authors.forename: M A C
authors.initials: MA
authors.lastname: Gabrielli
mesh_terms: D020341:Absorbable Implants; D000704:Analysis of Variance; D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D001863:Bone Screws; D016025:Bone Transplantation / Q000295:instrumentation / Q000379:methods*; D003487:Cyanoacrylates / Q000627:therapeutic use*; D005593:Fracture Fixation, Internal / Q000295:instrumentation / Q000379:methods; D008137:Longitudinal Studies; D008297:Male; D016348:Osseointegration / Q000187:drug effects / Q000502:physiology*; D010294:Parietal Bone / Q000601:surgery*; D011817:Rabbits; D014025:Titanium
chemical_list: D001843:Bone Cements; D003487:Cyanoacrylates; C029054:ethyl 2-cyanoacrylate; D014025:Titanium