title: Validation of 3 termination of resuscitation criteria for good neurologic survival after out-of-hospital cardiac arrest.
abstract: OBJECTIVE
  Several termination of resuscitation criteria have been proposed to identify patients who will not survive to hospital discharge after out-of-hospital cardiac arrest. However, only 1 set has been derived to specifically predict survival to hospital discharge with good neurologic function. The objectives of this study were to externally validate the basic life support (BLS) termination of resuscitation, advanced life support (ALS) termination of resuscitation, and neurologic termination of resuscitation criteria and compare their abilities to predict survival to hospital discharge with good neurologic function after out-of-hospital cardiac arrest.
  
  
  METHODS
  This was a secondary analysis of the Denver Cardiac Arrest Registry. Consecutive adult nontraumatic cardiac arrest patients in Denver County from January 1, 2003, through December 31, 2004, were included in the study. The BLS termination of resuscitation, ALS termination of resuscitation, and neurologic termination of resuscitation criteria were applied to the cohort, and their predictive proportions and 95% confidence intervals (CIs) were calculated for each set of criteria.
  
  
  RESULTS
  Of the 715 patients included in this study, the median age was 65 years (interquartile range 52 to 78 years), and 69% were male patients. In addition, 223 (31%) had return of spontaneous circulation, 175 (24%) survived to hospital admission, 58 (8%) survived to hospital discharge, and 42 (6%) survived to hospital discharge with good neurologic function. The proportion of patients with good neurologic survival to hospital discharge correctly identified for continued resuscitation was 100% (95% CI 92% to 100%) for all 3 termination of resuscitation criteria. The proportion of patients with poor neurologic survival to hospital discharge or no survival to hospital discharge correctly identified as eligible for termination of resuscitation was 36% (95% CI 32% to 40%) with the BLS termination of resuscitation criteria, 25% (95% CI 22% to 29%) with the ALS termination of resuscitation criteria, and 6% (95% CI 4% to 8%) with the neurologic termination of resuscitation criteria. Use of the BLS termination of resuscitation criteria would have reduced transport of the largest number of patients.
  
  
  CONCLUSIONS
  All 3 termination of resuscitation criteria had equally high abilities to identify patients requiring continued resuscitation. The BLS termination of resuscitation criteria, however, had the best combined ability to predict good neurologic survival and poor neurologic survival or death. These findings and the relative simplicity of the BLS termination of resuscitation criteria support their use.
authors.affiliation: University of Colorado Denver School of Medicine, Aurora, CO, USA.
authors.forename: Michael L
authors.initials: ML
authors.lastname: Ruygrok
authors.forename: Richard L
authors.initials: RL
authors.lastname: Byyny
authors.forename: Jason S
authors.initials: JS
authors.lastname: Haukoos
mesh_terms: D000368:Aged; D016887:Cardiopulmonary Resuscitation / Q000379:methods / Q000592:standards*; D003120:Colorado / Q000453:epidemiology; D003661:Decision Support Techniques; D004632:Emergency Medical Services / Q000592:standards*; D004636:Emergency Service, Hospital / Q000592:standards; D005260:Female; D006323:Heart Arrest / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008020:Life Support Care / Q000592:standards; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D010351:Patient Discharge / Q000706:statistics & numerical data; D012042:Registries; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D028761:Withholding Treatment / Q000592:standards*