title: Two clinical strains of Klebsiella pneumoniae carrying plasmid-borne blaIMP-4, blaSHV-12, and armA isolated at a Pediatric Center in Shanghai, China.
abstract: Two cases of pulmonary infection due to strains of multidrug-resistant Klebsiella pneumoniae were investigated. Beta-lactamase determinants, such as bla(IMP-4) and bla(SHV-12), and the 16S rRNA methyltransferase-encoding gene armA were detected in these plasmid-bearing organisms. The integron-borne bla(IMP-4) and armA contained intervening sequences highly related to those of a Vibrio cholerae O139 plasmid found in Hangzhou, China.
authors.affiliation: Clinical Laboratory Diagnostic Center, Xin Hua Hospital, Shanghai, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.forename: Qing
authors.initials: Q
authors.lastname: Cao
authors.forename: Weichun
authors.initials: W
authors.lastname: Huang
authors.forename: Lisong
authors.initials: L
authors.lastname: Shen
authors.forename: Xuan
authors.initials: X
authors.lastname: Qin
mesh_terms: D001483:Base Sequence; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007223:Infant; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; C425142:beta-lactamase IMP-4; C107198:beta-lactamase SHV-12; D001618:beta-Lactamases