Metastatic adrenocortical carcinoma treated with sunitinib: a case report.
Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Palliative chemotherapy can be considered in patients with metastatic disease. Although mitotane- or cisplatin-based chemotherapy regimens are widely used, the effects of these agents have been limited. We have experienced a case that showed a partial response with sunitinib after failure of mitotane-based cytotoxic chemotherapy. The clinical benefit from sunitinib persisted 7.5 months in this case. To our knowledge, this is the first reported case showing the effects of sunitinib on metastatic ACC.
Lee
Jeong-Ok
JO
Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeongi-do, Republic of Korea.
Lee
Keun-Wook
KW
Kim
Chung-Jong
CJ
Kim
Yu Jung
YJ
Lee
Hee Eun
HE
Kim
Haeryoung
H
Kim
Jee Hyun
JH
Bang
Soo-Mee
SM
Kim
Jae-Sung
JS
Lee
Jong Seok
JS
D000306:Adrenal Cortex Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000188:drug therapy* / Q000556:secondary*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D008939:Mitotane / Q000008:administration & dosage; D011758:Pyrroles / Q000627:therapeutic use*; D018714:Radiotherapy, Adjuvant; D000077210:Sunitinib; D017211:Treatment Failure; D016896:Treatment Outcome; D055815:Young Adult
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D008939:Mitotane; D000077210:Sunitinib