Lighting up H2O2: the molecule that is a "necessary evil" in the cell.
A cunning plan: In the multifunctional fluorescent probe MitoPY1 the phosphonium head group (red) targets mitochondria and the boronate group (green) responds to hydrogen peroxide. MitoPY1 reacts selectively with mitochondrial H(2)O(2) in living cells, and an increase in fluorescence is triggered by the conversion of MitoPY1 into MitoPY1ox (yellow).
Zhao
Wei
W
Department of Chemistry, University of Arkansas at Little Rock, 2801 South University Avenue, Little Rock, AR 72204, USA.
D000818:Animals; D002460:Cell Line; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000378:metabolism*; D008928:Mitochondria / Q000737:chemistry / Q000378:metabolism*; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry*
D005456:Fluorescent Dyes; C540996:MitoPY1 compound; D010879:Piperazines; D013141:Spiro Compounds; D006861:Hydrogen Peroxide