title: IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease.
abstract: BACKGROUND
  Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.
  
  
  METHODS
  We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.
  
  
  RESULTS
  Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples.
  
  
  CONCLUSIONS
  Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.
authors.affiliation: Department of Medical Genetics, Biomedicum Helsinki, University of Helsinki, Helsinki, Finland. elisabet.einarsdottir@helsinki.fi
authors.forename: Elisabet
authors.initials: E
authors.lastname: Einarsdottir
authors.forename: Lotta L E
authors.initials: LL
authors.lastname: Koskinen
authors.forename: Emma
authors.initials: E
authors.lastname: Dukes
authors.forename: Kati
authors.initials: K
authors.lastname: Kainu
authors.forename: Sari
authors.initials: S
authors.lastname: Suomela
authors.forename: Maarit
authors.initials: M
authors.lastname: Lappalainen
authors.forename: Fabiana
authors.initials: F
authors.lastname: Ziberna
authors.forename: Ilma R
authors.initials: IR
authors.lastname: Korponay-Szabo
authors.forename: Kalle
authors.initials: K
authors.lastname: Kurppa
authors.forename: Katri
authors.initials: K
authors.lastname: Kaukinen
authors.forename: Róza
authors.initials: R
authors.lastname: Adány
authors.forename: Zsuzsa
authors.initials: Z
authors.lastname: Pocsai
authors.forename: György
authors.initials: G
authors.lastname: Széles
authors.forename: Martti
authors.initials: M
authors.lastname: Färkkilä
authors.forename: Ulla
authors.initials: U
authors.lastname: Turunen
authors.forename: Leena
authors.initials: L
authors.lastname: Halme
authors.forename: Paulina
authors.initials: P
authors.lastname: Paavola-Sakki
authors.forename: Tarcisio
authors.initials: T
authors.lastname: Not
authors.forename: Serena
authors.initials: S
authors.lastname: Vatta
authors.forename: Alessandro
authors.initials: A
authors.lastname: Ventura
authors.forename: Robert
authors.initials: R
authors.lastname: Löfberg
authors.forename: Leif
authors.initials: L
authors.lastname: Torkvist
authors.forename: Francesca
authors.initials: F
authors.lastname: Bresso
authors.forename: Jonas
authors.initials: J
authors.lastname: Halfvarson
authors.forename: Markku
authors.initials: M
authors.lastname: Mäki
authors.forename: Kimmo
authors.initials: K
authors.lastname: Kontula
authors.forename: Ulpu
authors.initials: U
authors.lastname: Saarialho-Kere
authors.forename: Juha
authors.initials: J
authors.lastname: Kere
authors.forename: Mauro
authors.initials: M
authors.lastname: D'Amato
authors.forename: Päivi
authors.initials: P
authors.lastname: Saavalainen
mesh_terms: D016022:Case-Control Studies; D002446:Celiac Disease / Q000150:complications / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics*; D003424:Crohn Disease / Q000150:complications / Q000235:genetics*; D005387:Finland; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D006814:Hungary; D007558:Italy; D015810:Linkage Disequilibrium; D011565:Psoriasis / Q000150:complications / Q000235:genetics*; D018123:Receptors, Interleukin / Q000235:genetics*; D013548:Sweden
chemical_list: D005819:Genetic Markers; C515500:IL23R protein, human; D018123:Receptors, Interleukin