title: Clinical significance of serum tumour M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma.
abstract: OBJECTIVE
  To investigate the clinical significance of serum Tu M2-PK and CA19-9 detection in the diagnosis of cholangiocarcinoma.
  
  
  METHODS
  The tumour markers (Tu M2-PK and CA19-9) in 115 patients with cholangiocarcinoma, 85 patients with benign disease and 120 blood donors were detected by ELISA.
  
  
  RESULTS
  The levels of serum Tu M2-PK and CA19-9 were markedly higher in the patients with cholangiocarcinoma than in controls (P<0.05). Tu M2-PK showed more sensitivity (84.2%) and specificity (90%) than CA19-9 (68.4%) and (75%).
  
  
  CONCLUSIONS
  Tu M2-PK may be used as a valuable diagnosis marker in cholangiocarcinoma.
authors.affiliation: Department of Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China.
authors.forename: Y G
authors.initials: YG
authors.lastname: Li
authors.forename: N
authors.initials: N
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000175:diagnosis* / Q000473:pathology; D001653:Bile Ducts, Intrahepatic; D014408:Biomarkers, Tumor / Q000097:blood*; D018395:CA-19-9 Antigen / Q000097:blood*; D018281:Cholangiocarcinoma / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011770:Pyruvate Kinase / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D018395:CA-19-9 Antigen; D007527:Isoenzymes; D011770:Pyruvate Kinase