title: Ghrelin and apolipoprotein AIV levels show opposite trends to leptin levels during weight loss in morbidly obese patients.
abstract: BACKGROUND
  Although bariatric surgery is the most common procedure used to induce weight loss in morbidly obese patients, its effect on plasma satiety factors (leptin, ghrelin, and apolipoprotein (apo)-AIV) is controversial. The aim of this work was to analyze these parameters before and at different times after surgery.
  
  
  METHODS
  Plasma was obtained from 34 patients before undergoing Roux-en-Y gastric bypass and during weight loss in the 12 months following surgery.
  
  
  RESULTS
  Morbidly obese patients had significantly higher values (147%) of leptin than normal-weight (NW) persons, while their ghrelin levels were 46% less than NW. Apo-AIV levels had approximately the same value in both groups (obese and NW). During weight loss, leptin decreased by 75% and ghrelin increased by 78%. Both parameters reached values less than or near NW, respectively, at 1 year after surgery. During the first month after surgery, apo-AIV plasma levels decreased (47%) but later increased and finally returned to preoperative values. Apo-AIV levels were correlated negatively with leptin and positively with ghrelin. High-density lipoprotein (HDL) levels were positively correlated with those of ghrelin and apo-AIV.
  
  
  CONCLUSIONS
  During weight loss, plasma leptin and ghrelin could be good markers of total fat decrease. Ghrelin could also indicate gastric mucous improvement, whereas apo-AIV could indicate the recovery of intestinal function. Changes produced in the HDL levels of morbidly obese patients during weight loss suggest a decreased risk of coronary disease.
authors.affiliation: Dept. Bioquímica y Biología Molecular, Facultat de Biologia, Universitat de Barcelona, Diagonal, 645, 08028, Barcelona, Spain.
authors.forename: E
authors.initials: E
authors.lastname: Pardina
authors.forename: M D
authors.initials: MD
authors.lastname: López-Tejero
authors.forename: R
authors.initials: R
authors.lastname: Llamas
authors.forename: R
authors.initials: R
authors.lastname: Catalán
authors.forename: R
authors.initials: R
authors.lastname: Galard
authors.forename: H
authors.initials: H
authors.lastname: Allende
authors.forename: V
authors.initials: V
authors.lastname: Vargas
authors.forename: A
authors.initials: A
authors.lastname: Lecube
authors.forename: J M
authors.initials: JM
authors.lastname: Fort
authors.forename: J A
authors.initials: JA
authors.lastname: Baena-Fustegueras
authors.forename: J
authors.initials: J
authors.lastname: Peinado-Onsurbe
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D001054:Apolipoproteins A / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D015390:Gastric Bypass; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood* / Q000601:surgery; D012527:Satiation / Q000502:physiology; D013851:Thinness / Q000097:blood; D013997:Time Factors; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001054:Apolipoproteins A; D015415:Biomarkers; D054439:Ghrelin; D007328:Insulin; D020738:Leptin