title: Wegener's granulomatosis complicated by central diabetes insipidus and peripheral neutrophy with normal pituitary in a patient.
abstract: Wegener's granulomatosis (WG) is a necrotizing systemic vasculitis that any organ system can be involved in. We report a patient who was hospitalized with recurrent nodules in pulmonary computed tomograph and symptoms such as intermitted fever, polydipsia, insensibility and pain on extremities. Laboratory investigation showed positive antineutrophil cytoplasmic antibody in a cytoplastic pattern. The histopathologic result of the lung nodule revealed multiloci necrosis of lung tissue accompanied with large amount of neutrophils. She was diagnosed as WG with multi-systemic involvements and almost recovered on 6 months' prednisone and cyclophosphamide treatment.
authors.affiliation: Department of Rheumotology, The Second Affiliated Hospital of Zhejiang University Medical School, 310009, Hangzhou, Zhejiang, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xue
authors.forename: Huiying
authors.initials: H
authors.lastname: Wang
authors.forename: Huaxiang
authors.initials: H
authors.lastname: Wu
authors.forename: Qiaofei
authors.initials: Q
authors.lastname: Jin
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic; D003520:Cyclophosphamide / Q000627:therapeutic use; D020790:Diabetes Insipidus, Neurogenic / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008168:Lung / Q000473:pathology; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology*; D010902:Pituitary Gland / Q000166:cytology* / Q000000981:diagnostic imaging; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D003074:Solitary Pulmonary Nodule / Q000473:pathology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011241:Prednisone