title: Stabilization of an alpha helix by beta-sheet-mediated self-assembly of a macrocyclic peptide.
abstract: Protein roll call: Peptide-based building blocks, in which both an alpha-helix-forming segment and a beta-sheet segment are located within a single macrocyclic structure, self-assemble into alpha-helix-decorated artificial proteins. This approach provides a starting point for developing artificial proteins that can modulate alpha-helix-mediated interactions occurring in a multivalent fashion.
authors.affiliation: Center for Supramolecular Nano-Assembly and Department of Chemistry, Yonsei University, Seoul 120-749, Korea.
authors.forename: Yong-beom
authors.initials: YB
authors.lastname: Lim
authors.forename: Kyung-Soo
authors.initials: KS
authors.lastname: Moon
authors.forename: Myongsoo
authors.initials: M
authors.lastname: Lee
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D046529:Microscopy, Electron, Transmission; D010456:Peptides, Cyclic / Q000737:chemistry*; D017433:Protein Structure, Secondary
chemical_list: D010456:Peptides, Cyclic