title: Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease influenced by genetic and environmental factors. We carried out a genome-wide association scan and replication study and found an association between SLE and a variant in TNFAIP3 (rs5029939, meta-analysis P = 2.89 x 10(-12), OR = 2.29). We also found evidence of two independent signals near TNFAIP3 associated with SLE, including one previously associated with rheumatoid arthritis (RA). These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA.
authors.affiliation: Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Graham
authors.forename: Chris
authors.initials: C
authors.lastname: Cotsapas
authors.forename: Leela
authors.initials: L
authors.lastname: Davies
authors.forename: Rachel
authors.initials: R
authors.lastname: Hackett
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Lessard
authors.forename: Joanlise M
authors.initials: JM
authors.lastname: Leon
authors.forename: Noel P
authors.initials: NP
authors.lastname: Burtt
authors.forename: Candace
authors.initials: C
authors.lastname: Guiducci
authors.forename: Melissa
authors.initials: M
authors.lastname: Parkin
authors.forename: Casey
authors.initials: C
authors.lastname: Gates
authors.forename: Robert M
authors.initials: RM
authors.lastname: Plenge
authors.forename: Timothy W
authors.initials: TW
authors.lastname: Behrens
authors.forename: Joan E
authors.initials: JE
authors.lastname: Wither
authors.forename: John D
authors.initials: JD
authors.lastname: Rioux
authors.forename: Paul R
authors.initials: PR
authors.lastname: Fortin
authors.forename: Deborah Cunninghame
authors.initials: DC
authors.lastname: Graham
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Wong
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Vyse
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Daly
authors.forename: David
authors.initials: D
authors.lastname: Altshuler
authors.forename: Kathy L
authors.initials: KL
authors.lastname: Moser
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Gaffney
mesh_terms: D001172:Arthritis, Rheumatoid / Q000235:genetics; D002896:Chromosomes, Human, Pair 6; D004268:DNA-Binding Proteins; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3
chemical_list: D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; C076529:TNFAIP3 protein, human; D000072598:Tumor Necrosis Factor alpha-Induced Protein 3