Diarrhea as a minor adverse effect due to oral polio vaccine.
Using the adverse events monitoring system of Japan, we observed diarrhea cases in approximately 10% of patients who received oral poliovirus vaccine (OPV). This study was conducted to investigate whether diarrhea among children aged 0 to 1 is caused by OPV or by other factors such contact at the doctor's office and/or with others outside the home. We conducted a survey of the health of children after regular health check-ups and after the administration of the OPV. The data from the health check-ups were used as a control for the OPV case group. We compared the first-OPV dose vaccination group as well as the second-OPV dose vaccination group to the health check-up group. For cases of diarrhea, the odds ratio of the OPV group to the health check-up group was 1.776. Our findings strongly suggest that post-OPV cases of mild diarrhea are closely related to the administration of the OPV.
Sugawara
Tamie
T
National Institute of Infectious Diseases, Tokyo 162-8640, Japan. tammy@nih.go.jp
Ohsuka
Yasushi
Y
Taya
Keiko
K
Yasui
Yoshinori
Y
Wada
Noriyuki
N
Sakano
Masasi
M
Koshida
Rie
R
Fujii
Fumitoshi
F
Shibata
Senko
S
Hashimoto
Goutaro
G
Utsumi
Hiromi
H
Sumitomo
Masami
M
Ishihara
Michiyo
M
Kondo
Hirokazu
H
Sato
Hiroshi
H
Ueno
Kumi
K
Araki
Kazuko
K
Okabe
Nobuhiko
N
D016907:Adverse Drug Reaction Reporting Systems; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000139:chemically induced* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D011159:Population Surveillance; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
D011055:Poliovirus Vaccine, Oral