Interactions of a tetraanionic porphyrin with DNA: from a Z-DNA sensor to a versatile supramolecular device.
The anionic nickel(II) porphyrin NiTPPS is able to selectively sense the spermine induced left-handed Z-form of DNA while it is completely silent in the presence of right-handed B-DNA. Interactions between the DNA and the porphyrin can be easily modulated by pH and temperature. The resulting Z-DNA-porphyrin-spermine complex behaves as a supramolecular reversible information storage system and as a reversible AND logic gate.
D'Urso
Alessandro
A
Dipartimento di Scienze Chimiche, Università di Catania, 95125 Catania, Italy.
Mammana
Angela
A
Balaz
Milan
M
Holmes
Andrea E
AE
Berova
Nina
N
Lauceri
Rosaria
R
Purrello
Roberto
R
D002942:Circular Dichroism; D043542:DNA, Z-Form / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D046911:Macromolecular Substances / Q000737:chemistry; D008665:Metalloporphyrins / Q000737:chemistry*; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides / Q000737:chemistry; D011166:Porphyrins / Q000737:chemistry; D013096:Spermine / Q000737:chemistry; D013237:Stereoisomerism
D043542:DNA, Z-Form; D046911:Macromolecular Substances; D008665:Metalloporphyrins; D011089:Polydeoxyribonucleotides; D011166:Porphyrins; C019530:poly(dC-dG); D013096:Spermine; C016136:tetraphenylporphine sulfonate; D009532:Nickel