title: Increased UVA exposures and decreased cutaneous Vitamin D(3) levels may be responsible for the increasing incidence of melanoma.
abstract: Cutaneous malignant melanoma (CMM) has been increasing at a steady exponential rate in fair-skinned, indoor workers since before 1940. A paradox exists between indoor and outdoor workers because indoor workers get three to nine times less solar UV (290-400 nm) exposure than outdoor workers get, yet only indoor workers have an increasing incidence of CMM. Thus, another "factor(s)" is/are involved that increases the CMM risk for indoor workers. We hypothesize that one factor involves indoor exposures to UVA (321-400 nm) passing through windows, which can cause mutations and can break down vitamin D(3) formed after outdoor UVB (290-320 nm) exposure, and the other factor involves low levels of cutaneous vitamin D(3). After vitamin D(3) forms, melanoma cells can convert it to the hormone, 1,25-dihydroxyvitamin D(3), or calcitriol, which causes growth inhibition and apoptotic cell death in vitro and in vivo. We measured the outdoor and indoor solar irradiances and found indoor solar UVA irradiances represent about 25% (or 5-10 W/m(2)) of the outdoor irradiances and are about 60 times greater than fluorescent light irradiances. We calculated the outdoor and indoor UV contributions toward different biological endpoints by weighting the emission spectra by the action spectra: erythema, squamous cell carcinoma, melanoma (fish), and previtamin D(3). Furthermore, we found production of previtamin D(3) only occurs outside where there is enough UVB. We agree that intense, intermittent outdoor UV overexposures and sunburns initiate CMM; we now propose that increased UVA exposures and inadequately maintained cutaneous levels of vitamin D(3) promotes CMM.
authors.affiliation: US Food and Drug Administration, Center for Devices and Radiological Health, 10903 New Hampshire Avenue (HFZ-120), Silver Spring, MD 20993-0002, USA. DEG@CDRH.FDA.GOV
authors.forename: Dianne E
authors.initials: DE
authors.lastname: Godar
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Landry
authors.forename: Anne D
authors.initials: AD
authors.lastname: Lucas
mesh_terms: D002762:Cholecalciferol / Q000378:metabolism*; D006801:Humans; D015994:Incidence; D008545:Melanoma / Q000209:etiology* / Q000378:metabolism; D012867:Skin / Q000378:metabolism / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000209:etiology* / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D002762:Cholecalciferol