title: Adiposity and gastrointestinal malignancy.
abstract: Recent epidemiologic studies have shown a positive association between obesity and certain cancers. Our retrospective studies show that hypertriglyceridemia is an independent risk factor for the development of colonic adenoma and nodal metastasis in early gastric and esophageal cancer in men. High-fat condition may be favorable for the growth of malignant cells. Serum level of adiponectin is reduced in patients with advanced gastric cancer, which may be associated with the positive link between adiposity and cancer. In early gastric cancer, patients with undifferentiated type have lower fat volume than those with differentiated type. Adiposity appears to be closely related with various aspects in pathophysiology of gastrointestinal malignancy.
authors.affiliation: Department of Surgical Oncology, University of Tokyo, Tokyo, Japan. kitayama-1SU@h.u-tokyo.ac.jp
authors.forename: Joji
authors.initials: J
authors.lastname: Kitayama
authors.forename: Masafumi
authors.initials: M
authors.lastname: Tabuchi
authors.forename: Giichiro
authors.initials: G
authors.lastname: Tsurita
authors.forename: Makoto
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Kensuke
authors.initials: K
authors.lastname: Otani
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nagawa
mesh_terms: D000236:Adenoma / Q000097:blood / Q000209:etiology*; D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D002277:Carcinoma / Q000097:blood / Q000209:etiology*; D015179:Colorectal Neoplasms / Q000097:blood / Q000209:etiology*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000150:complications; D006949:Hyperlipidemias / Q000150:complications; D008207:Lymphatic Metastasis; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000097:blood / Q000209:etiology*
chemical_list: D052242:Adiponectin