Protective effects of the complex between manganese porphyrins and catalase-poly(ethylene glycol) conjugates against hepatic ischemia/reperfusion injury in vivo.
The complex between manganese (Mn) porphyrins and catalase-poly(ethylene glycol) (PEG) conjugates has been designed for the protective effect against hepatic ischemia/reperfusion injury in vivo. The resulting Mn-porphyrin/catalase-PEG complex with dual enzymatic activity of superoxide dismutase (SOD) and catalase enhanced the blood circulation. The spin reduction rate in the rats treated with the Mn-porphyrin/catalase-PEG complex was significantly higher than that in the untreated rats and almost equal to that in the sham group rats. Furthermore, the Mn-porphyrin/catalase-PEG complex significantly decreased the serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels. These results suggest that the Mn-porphyrin/catalase-PEG complex exhibited the antioxidative activity to protect hepatic ischemia/reperfusion injury in vivo.
Hanawa
Tomochika
T
Department of Applied Chemistry, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, Japan.
Asayama
Shoichiro
S
Watanabe
Taiji
T
Owada
Shigeru
S
Kawakami
Hiroyoshi
H
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D002374:Catalase / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000494:pharmacology*; D004339:Drug Compounding; D004355:Drug Stability; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008111:Liver Function Tests; D008297:Male; D008665:Metalloporphyrins / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*
D000975:Antioxidants; D008665:Metalloporphyrins; D017382:Reactive Oxygen Species; D011092:Polyethylene Glycols; C050950:tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex; D002374:Catalase