Cytotoxic guanidine alkaloids from Pterogyne nitens.
As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.
Regasini
Luis Octávio
LO
Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products, NuBBE, Sao Paulo State University, UNESP, Araraquara, SP, Brazil.
Castro-Gamboa
Ian
I
Silva
Dulce Helena Siqueira
DH
Furlan
Maysa
M
Barreiro
Eliezer Jesus
EJ
Ferreira
Paulo Michel Pinheiro
PM
Pessoa
Cláudia
C
Lotufo
Letícia Veras Costa
LV
de Moraes
Manoel Odorico
MO
Young
Maria Claudia Marx
MC
Bolzani
Vanderlan da Silva
Vda S
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006146:Guanidines; C548768:nitensidine D; C548769:nitensidine E