title: [Effects of penetration enhancers on percutaneous permeability of geniposide in Xiao'er Ninhuang tuire cataplasms].
abstract: OBJECTIVE
  To investigate the different permeation enhancers on the transdermal permeation of Xiao'er Niuhuang tuire cataplasms (XNTC).
  
  
  METHODS
  Using improved franz-type diffusion cell with excised rat skin in vitro as the transdermal barrier, the content of permeated geniposide was determined by HPLC to study the kinetic parameters such as cumulative permeation quantity and permeation rate.
  
  
  RESULTS
  The result showed that the process of penetrating of geniposide in XNTC through skin could be in accordance with zero-rade releasing equation and XNTC was stable during the course of experiment.
  
  
  CONCLUSIONS
  5% Propylene glycol (PG)-azone (2:3) has the best permeation-enhancing effect, and the results provided a primary basis for the future research on Xiao'er Niuhuang tuire cataplasms.
authors.affiliation: Hubei Engineering Technology Centre of Modernization of Traditional Chinese Medicine, Wuhan 430052, China. szhlww2006@163.com
authors.forename: Zhao-Hua
authors.initials: ZH
authors.lastname: Shi
authors.forename: Fu-Liang
authors.initials: FL
authors.lastname: Xiong
authors.forename: Zhi-Jun
authors.initials: ZJ
authors.lastname: Huang
authors.forename: Deng-Ke
authors.initials: DK
authors.lastname: Xiong
authors.forename: Qing-Hui
authors.initials: QH
authors.lastname: Zeng
mesh_terms: D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D066298:In Vitro Techniques; D039823:Iridoids / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000494:pharmacology*; D019946:Propylene Glycol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012869:Skin Absorption / Q000187:drug effects*
chemical_list: D001381:Azepines; D004365:Drugs, Chinese Herbal; D039823:Iridoids; D014677:Pharmaceutical Vehicles; C007835:geniposide; C035229:laurocapram; D019946:Propylene Glycol