title: A new antioxidant, clitocybin A, from the culture broth of Clitocybe aurantiaca.
abstract: Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-p-hydroxyphenyl-isoindol1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.
authors.affiliation: Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Sung-Min
authors.initials: SM
authors.lastname: Cho
authors.forename: Jin-Won
authors.initials: JW
authors.lastname: Hyun
authors.forename: In-Ja
authors.initials: IJ
authors.lastname: Ryoo
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Choo
authors.forename: Sangku
authors.initials: S
authors.lastname: Lee
authors.forename: Soon-Ja
authors.initials: SJ
authors.lastname: Seok
authors.forename: Jae Sung
authors.initials: JS
authors.lastname: Hwang
authors.forename: Eui Dong
authors.initials: ED
authors.lastname: Sohn
authors.forename: Bong-Sik
authors.initials: BS
authors.lastname: Yun
authors.forename: Ki Hwan
authors.initials: KH
authors.lastname: Bae
authors.forename: Ick-Dong
authors.initials: ID
authors.lastname: Yoo
mesh_terms: D000363:Agaricales / Q000378:metabolism*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D054833:Isoindoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D016166:Free Radical Scavengers; D054833:Isoindoles; C535086:clitocybin A