The analysis of IL-1 beta and its naturally occurring inhibitors in multiple sclerosis: The elevation of IL-1 receptor antagonist and IL-1 receptor type II after steroid therapy.
The aim of our investigation was to analyze the pattern of interleukin-1 (IL-1) family compounds: IL-1 beta, IL-1 receptor accessory protein (Acp), IL-1 receptor antagonist (IL-1Ra) and IL-1 receptor type II (IL-1RII) in the serum and cerebrospinal fluid (CSF) from 67 multiple sclerosis (MS) patients and 31 controls. We found significantly elevated CSF levels of IL-1 beta, IL-1Ra and Acp in MS patients compared to controls (p=0.001), while IL-1 beta and Acp were significantly elevated in MS sera (p=0.001). IL-1Ra and/or IL-1 RII increased in sera of all 10 investigated patients after the steroid treatment for relapse. Our findings suggest the important beneficial role of the induction of IL-1 RII and IL-1Ra in MS.
Dujmovic
Irena
I
Institute of Neurology, Clinical Centre of Serbia, Dr Subotica 6, Belgrade 11000, Serbia. irdujm@EUnet.yu
Mangano
Katia
K
Pekmezovic
Tatjana
T
Quattrocchi
Cinzia
C
Mesaros
Sarlota
S
Stojsavljevic
Nebojsa
N
Nicoletti
Ferdinando
F
Drulovic
Jelena
J
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000378:metabolism*; D053577:Interleukin-1 Receptor Accessory Protein / Q000378:metabolism*; D053583:Interleukin-1beta / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D053574:Receptors, Interleukin-1 Type II / Q000378:metabolism*; D018709:Statistics, Nonparametric; D013256:Steroids / Q000627:therapeutic use; D055815:Young Adult
D053590:Interleukin 1 Receptor Antagonist Protein; D053577:Interleukin-1 Receptor Accessory Protein; D053583:Interleukin-1beta; D053574:Receptors, Interleukin-1 Type II; D013256:Steroids