Two clinical strains of Klebsiella pneumoniae carrying plasmid-borne blaIMP-4, blaSHV-12, and armA isolated at a Pediatric Center in Shanghai, China.
Two cases of pulmonary infection due to strains of multidrug-resistant Klebsiella pneumoniae were investigated. Beta-lactamase determinants, such as bla(IMP-4) and bla(SHV-12), and the 16S rRNA methyltransferase-encoding gene armA were detected in these plasmid-bearing organisms. The integron-borne bla(IMP-4) and armA contained intervening sequences highly related to those of a Vibrio cholerae O139 plasmid found in Hangzhou, China.
Liu
Ying
Y
Clinical Laboratory Diagnostic Center, Xin Hua Hospital, Shanghai, China.
Zhang
Bei
B
Cao
Qing
Q
Huang
Weichun
W
Shen
Lisong
L
Qin
Xuan
X
D001483:Base Sequence; D002648:Child; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007223:Infant; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics; D008780:Methyltransferases / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; C425142:beta-lactamase IMP-4; C107198:beta-lactamase SHV-12; D001618:beta-Lactamases