Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB.
Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus etiologically causal of adult T-cell leukemia (ATL). The virus encodes a Tax oncoprotein that functions in transcriptional regulation, cell cycle control, and transformation. ATL is a highly virulent cancer that is resistant to chemotherapeutic treatments. To understand this disease better, it is important to comprehend how HTLV-1 promotes cellular growth and survival. Tax activation of NF-kappaB is important for the proliferation and transformation of virus-infected cells. We show here that prolyl isomerase Pin1 is over expressed in HTLV-1 cell lines; Pin1 binds Tax and regulates Tax-induced NF-kappaB activation.
Peloponese
Jean-Marie
JM
Molecular Virology Section, Laboratory of Molecular, Microbiology, the National Institute of Allergy and Infectious Diseases, the National Institutes of Health, Bethesda, Maryland 20892-0460, USA. jean-marie.peloponese@univ-montp1.fr
Yasunaga
Junichiro
J
Kinjo
Takao
T
Watashi
Koichi
K
Jeang
Kuan-Teh
KT
D002460:Cell Line; D016356:Gene Products, tax / Q000378:metabolism*; D015368:Human T-lymphotropic virus 1 / Q000502:physiology*; D006801:Humans; D016328:NF-kappa B / Q000378:metabolism*; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D011485:Protein Binding
D016356:Gene Products, tax; D016328:NF-kappa B; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; C514970:tax protein, Human T-lymphotrophic virus 1; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase