title: Impact of preoperative overt hepatic encephalopathy on neurocognitive function after liver transplantation.
abstract: In the current Model for End-Stage Liver Disease allocation system, patients are at risk of suffering repeated episodes of hepatic encephalopathy (HE) while waiting for an orthotopic liver transplantation (OLT); the posttransplantation impact of these episodes has not been well explored. We evaluated the cognitive function and quality of life in a group of OLT recipients (n = 25) who had suffered from overt HE prior to their procedure (HE-PreLT group) and compared their performance to that of a similar group of patients (n = 14) without overt HE (No HE-PreLT group) as well as to controls. Patients were selected from a cohort of 280 patients who underwent OLT during this period; the presence of clinical confounders excluded many of the remaining subjects. Demographic and clinical characteristics were balanced among groups. At an average of 18 months after OLT, we administered 2 neuropsychological batteries [Psychometric Hepatic Encephalopathy Score (PHES) test battery and Repeatable Battery for the Assessment of Neuropsychological Status (RBANS)]; a pyschophysiological test (critical flicker frequency); and the SF-36 quality of life score. The HE-PreLT group scored below controls in 5 of 6 cognitive domains tested by RBANS, 3 of 6 PHES subtests, as well as the critical flicker frequency test. The No HE-PreLT group scored below the controls in 1 of the 6 cognitive domains tested by RBANS. The more severe neurocognitive abnormalities seen in the HE-PreLT group did not appear to affect quality of life, as lower values than normative data were only found in 1 of the 8 SF-36 scales. In conclusion, neurocognitive abnormalities were more severe in liver transplant recipients that had suffered from overt HE prior to OLT. Prospective studies of neurocognitive function pre-OLT and post-OLT are needed to fully determine the impact of such abnormalities.
authors.affiliation: Division of Hepatology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
authors.forename: Eva U
authors.initials: EU
authors.lastname: Sotil
authors.forename: Jeanne
authors.initials: J
authors.lastname: Gottstein
authors.forename: Edgar
authors.initials: E
authors.lastname: Ayala
authors.forename: Christopher
authors.initials: C
authors.lastname: Randolph
authors.forename: Andres T
authors.initials: AT
authors.lastname: Blei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003071:Cognition; D005260:Female; D006501:Hepatic Encephalopathy / Q000150:complications*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects* / Q000523:psychology*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life