title: Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution.
abstract: The degree of absorption of bioflavonoids, a diverse and complex group of plant derived phytonutrients, has been a frequent debate among scientists. Monomeric flavonoid species are known to be absorbed within 2 h. The kinetics of plasma reactive oxygen species, a reflection of bioactivity, of a commercial blend of flavonoids, OPC-3 was investigated. OPC-3 was selected to compare absorption of an isotonic flavonoid solution vs tablet form with the equivalent amount of fluid. In the case of isotonic OPC-3 the reactive oxygen species of the subject's plasma decreased significantly (p < 0.05), six times greater than OPC-3 tablets by 10 min post-consumption. After 20 min the isotonic formulation was approximately four times more bioavailable and after 40 min twice as bioavailable as the tablet, respectively. At time points 1 h and later, both isotonic and tablet formulations lowered oxidative stress, although the isotonic formulation values remained significantly better throughout the investigation period of 4 h. These findings point to a dramatically accelerated bioavailability of flavonoids delivered in an isotonic formulation.
authors.affiliation: Department of Biomedical Science, G D'Annunzio University Chieti, Pescara, Italy.
authors.forename: Maria R
authors.initials: MR
authors.lastname: Cesarone
authors.forename: Maria Giovanni
authors.initials: MG
authors.lastname: Grossi
authors.forename: Andrea
authors.initials: A
authors.lastname: Di Renzo
authors.forename: Silvia
authors.initials: S
authors.lastname: Errichi
authors.forename: Frank
authors.initials: F
authors.lastname: Schönlau
authors.forename: James L
authors.initials: JL
authors.lastname: Wilmer
authors.forename: Mark
authors.initials: M
authors.lastname: Lange
authors.forename: Julian
authors.initials: J
authors.lastname: Blumenfeld
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001682:Biological Availability; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D007552:Isotonic Solutions; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000097:blood; D013607:Tablets
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D007552:Isotonic Solutions; D017382:Reactive Oxygen Species; D013607:Tablets