A palladium(II)-catalyzed synthesis of spiroacetals through a one-pot multicomponent cascade reaction.
Functionalized spiroacetals have been easily prepared in a one-pot three-component coupling process that involves the reaction of pentynol derivatives, salicylaldehydes, and amines in the presence of catalytic amounts of a palladium(II) complex (see scheme). Alternatively, oxygen-substituted spiroacetals can be obtained by using orthoesters as the third component.
Barluenga
José
J
Instituto Universitario de Química Organometálica Enrique Moles, Unidad Asociada al C.S.I.C., Universidad de Oviedo, Julián Clavería, 8; 33006 Oviedo, Spain. barluenga@uniovi.es
Mendoza
Abraham
A
Rodríguez
Félix
F
Fañanás
Francisco J
FJ
D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*
D000080:Acetals; D000447:Aldehydes; D000588:Amines; C013243:salicylaldehyde; D010165:Palladium