title: Exercise improves cardiovascular control in a model of dislipidemia and menopause.
abstract: The present study investigated the effects of exercise training on arterial pressure, baroreflex sensitivity, cardiovascular autonomic control and metabolic parameters on female LDL-receptor knockout ovariectomized mice. Mice were divided into two groups: sedentary and trained. Trained group was submitted to an exercise training protocol. Blood cholesterol was measured. Arterial pressure (AP) signals were directly recorded in conscious mice. Baroreflex sensitivity was evaluated by tachycardic and bradycardic responses to AP changes. Cardiovascular autonomic modulation was measured in frequency (FFT) and time domains. Maximal exercise capacity was increased in trained as compared to sedentary group. Blood cholesterol was diminished in trained mice (191+/-8mg/dL) when compared to sedentary mice (250+/-9mg/dL, p<0.05). Mean AP and HR were reduced in trained group (101+/-3mmHg and 535+/-14bpm, p<0.05) when compared with sedentary group (125+/-3mmHg and 600+/-12bpm). Exercise training induced improvement in bradycardic reflex response in trained animals (-4.24+/-0.62bpm/mmHg) in relation to sedentary animals (-1.49+/-0.15bpm/mmHg, p<0.01); tachycardic reflex responses were similar between studied groups. Exercise training increased the variance (34+/-8 vs. 6.6+/-1.5ms(2) in sedentary, p<0.005) and the high-frequency band (HF) of the pulse interval (IP) (53+/-7% vs. 26+/-6% in sedentary, p<0.01). It is tempting to speculate that results of this experimental study might represent a rationale for this non-pharmacological intervention in the management of cardiovascular risk factors in dyslipidemic post-menopause women.
authors.affiliation: Human Movement Laboratory, São Judas Tadeu University, Rua Taquari, 546, Sao Paulo - São Paulo 03166-000, Brazil.
authors.forename: Marcelo Velloso
authors.initials: MV
authors.lastname: Heeren
authors.forename: Leandro Eziquiel
authors.initials: LE
authors.lastname: De Sousa
authors.forename: Cristiano
authors.initials: C
authors.lastname: Mostarda
authors.forename: Edson
authors.initials: E
authors.lastname: Moreira
authors.forename: Henrique
authors.initials: H
authors.lastname: Machert
authors.forename: Katya Vianna
authors.initials: KV
authors.lastname: Rigatto
authors.forename: Rogério Brandão
authors.initials: RB
authors.lastname: Wichi
authors.forename: M C
authors.initials: MC
authors.lastname: Irigoyen
authors.forename: Kátia
authors.initials: K
authors.lastname: De Angelis
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002320:Cardiovascular Physiological Phenomena; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000628:therapy*; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008593:Menopause / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D023421:Models, Animal; D010805:Physical Conditioning, Animal / Q000502:physiology*
chemical_list: D002784:Cholesterol