title: The design and characterization of a digital optical breast cancer imaging system.
abstract: Optical imaging has the potential to play a major role in breast cancer screening and diagnosis due to its ability to image cancer characteristics such as angiogenesis and hypoxia. A promising approach to evaluate and quantify these characteristics is to perform dynamic imaging studies in which one monitors the hemodynamic response to an external stimulus, such as a valsalva maneuver. It has been shown that the response to such stimuli shows MARKED differences between cancerous and healthy tissues. The fast imaging rates and large dynamic range of digital devices makes them ideal for this type of imaging studies. Here we present a digital optical tomography system designed specifically for dynamic breast imaging. The instrument uses laser diodes at 4 different near-infrared wavelengths with 32 sources and 128 silicon photodiode detectors.
authors.affiliation: Biomedical Engineering Department, Columbia University, New York, NY 10027, USA. mlf2129@columbia.edu
authors.forename: Molly L
authors.initials: ML
authors.lastname: Flexman
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Andres M
authors.initials: AM
authors.lastname: Bur
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Fong
authors.forename: James M
authors.initials: JM
authors.lastname: Masciotti
authors.forename: Rabah
authors.initials: R
authors.lastname: Al Abdi
authors.forename: Randall L
authors.initials: RL
authors.lastname: Barbour
authors.forename: Andreas H
authors.initials: AH
authors.lastname: Hielscher
mesh_terms: D000465:Algorithms; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003201:Computers; D004867:Equipment Design; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation* / Q000379:methods*; D055095:Optics and Photonics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods; D013382:Subtraction Technique; D041622:Tomography, Optical / Q000295:instrumentation* / Q000379:methods; D014463:Ultrasonography