[Role of heart-type fatty acid binding protein in the brain function].
Long-chain polyunsaturated fatty acids (LCPUFAs) are components of membrane phospholipids and they are abundant in the brain. LCPUFAs are supposed to be involved in several brain functions including emotion, learning and memory. However, the mechanisms of effects of LCPUFAs on brain functions at cellular and molecular levels remains unclear. Because LCPUFAs are insoluble in the intracellular compartment, specific transporters are required to deliver LCPUFAs for appropriate intracellular compartments. Fatty acid binding proteins (FABPs) are believed to play crucial roles as their cellular shuttles. Among various FABPs, heart-type fatty acid binding protein (H-FABP) is highly expressed in neurons of the mature brain and involved in arachidonic acid incorporation in the brain. Moreover, the association of H-FABP and dopamine D2L receptor has been documented by our studies. In this context, we here examined behavioral and molecular biological phenotype of H-FABP gene-ablated mice to clarify function of H-FABP in the higher brain functions.
Motohashi
Keiju
K
Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Yamamoto
Yui
Y
Shioda
Norifumi
N
Kondo
Hisatake
H
Owada
Yuji
Y
Fukunaga
Kohji
K
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D017362:Cyclic AMP Response Element-Binding Protein; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005231:Fatty Acids, Unsaturated / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000209:etiology; D051379:Mice; D009474:Neurons / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000502:physiology
D017362:Cyclic AMP Response Element-Binding Protein; C493408:FABP3 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D005231:Fatty Acids, Unsaturated; D017448:Receptors, Dopamine D2; C113776:dopamine D2L receptor; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2