Considerations on Chlamydia trachomatis disease expression.
Chlamydia disease expression is the result of complex molecular and cellular interactions between the host and a pathogen which appears to have been sculpted by evolutionary forces. Recent genomic, immunologic, and epidemiologic findings are reviewed. A synthesis is offered which suggests that Chlamydia disease expression results from persistent infection and host immune responses.
Brunham
Robert C
RC
University of British Columbia and British Columbia Centre for Disease Control, Vancouver, BC, Canada. robert.brunham@bccdc.ca
Rekart
Michael L
ML
D002690:Chlamydia Infections / Q000453:epidemiology* / Q000276:immunology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology* / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans