Cryptococcal liver abscess: a case report of successful treatment with amphotericin-B and literature review.
Cryptococcus neoformans usually involves the central nervous system and the respiratory tract. We report a case of disseminated cryptococcosis with a liver abscess and meningoencephalitis in a patient with myelodysplastic syndrome. Computed tomography of the abdomen showed a 3-cm low-attenuated lesion in the left lobe of liver. Cultures from specimens of blood, the liver abscess, and the cerebrospinal fluid all yielded C. neoformans. The cryptococcal antigen titers for the serum and cerebral fluid were both 1:32. The patient was successfully treated with 1,335 mg of amphotericin-B followed by fluconazole. Most cryptococcal liver infections present as hepatitis, cholangitis, or microabscesses.
Liu
Po-Yu
PY
Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. pyliu@vghtc.gov.tw
Yang
Youngsen
Y
Shi
Zhi-Yuan
ZY
D000368:Aged; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000946:Antigens, Fungal / Q000032:analysis; D003453:Cryptococcosis / Q000188:drug therapy / Q000276:immunology*; D003455:Cryptococcus neoformans / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008100:Liver Abscess / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000946:Antigens, Fungal; D000666:Amphotericin B; D015725:Fluconazole