title: Investigation of T cell receptors in the peripheral blood of patients with active pulmonary tuberculosis.
abstract: T cells have the capability of recognizing target cells through their T cell receptors (TCRs). Thus, the percentages of CD3+/gamma-delta (gammadelta) TCR+ and CD3+/alpha-beta (alphabeta) TCR+ T lymphocytes were investigated in active and inactive pulmonary tuberculosis (PT) patients and in healthy individuals. CD3+ and CD3+/alphabeta TCR+ cell percentages were significantly lower in all PT patients than in healthy subjects. Percentages of CD3+/gammadelta and CD3+/alphabeta TCR+ were not statistically different between active and inactive PT patients. It was concluded that alphabeta TCR+ T cells might have a protective role in tuberculosis infection.
authors.affiliation: Department of Immunology, Faculty of Medicine, Firat University, Elazig 23119, Turkey. handanakbulut@yahoo.com
authors.forename: H H
authors.initials: HH
authors.lastname: Akbulut
authors.forename: F
authors.initials: F
authors.lastname: Deveci
authors.forename: I
authors.initials: I
authors.lastname: Celik
authors.forename: F
authors.initials: F
authors.lastname: Ilhan
authors.forename: T
authors.initials: T
authors.lastname: Turgut
mesh_terms: D000328:Adult; D001769:Blood / Q000276:immunology* / Q000382:microbiology*; D017252:CD3 Complex / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D055815:Young Adult
chemical_list: D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell