title: Association between 894G>T endothelial nitric oxide synthase gene polymorphisms and metabolic syndrome.
abstract: Metabolic syndrome (MS) is a cluster of cardiovascular risk factors such as hypertension, dyslipidemia, obesity and type II diabetes. Here, we performed a case-control study analyzing the association between 894G>T endothelial nitric oxide synthase gene polymorphism (NOS3) and MS in 616 subjects. Genotype frequencies were TT= 9.3%, GG= 37.2 and TG= 53.6% and the allelic frequencies were T=0.36 and G= 0.64. We observed a higher TT genotype frequency in the male MS group than control subjects (p=0.02), independent of other variables. We found an association between hypertension and TT genotype in females. Our data suggests that 894G>T plays a significant role in the mechanistic interaction between metabolic risk such as hypertension and MS, although sex-related differences may exist.
authors.affiliation: Departamento de Morfologia, Centro de Ciências da Saúde, Universidade Federal de Santa Maria, RS, Brasil.
authors.forename: Jacqueline C Escobar
authors.initials: JC
authors.lastname: Piccoli
authors.forename: Maria Gabriela Valle
authors.initials: MG
authors.lastname: Gottlieb
authors.forename: Luciano
authors.initials: L
authors.lastname: Castro
authors.forename: Luiz Carlos
authors.initials: LC
authors.lastname: Bodanese
authors.forename: Euler Roberto Fernandes
authors.initials: ER
authors.lastname: Manenti
authors.forename: Mauricio Reis
authors.initials: MR
authors.lastname: Bogo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Peres
authors.forename: Maria Izabel U M da
authors.initials: MI
authors.lastname: Rocha
authors.forename: Ivana Beatrice Mânica da
authors.initials: IB
authors.lastname: Cruz
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004812:Epidemiologic Methods; D005260:Female; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III