Concurrent release of admixed antimicrobials and salicylic acid from salicylate-based poly(anhydride-esters).
A polymer blend consisting of antimicrobials (chlorhexidine, clindamycin, and minocycline) physically admixed at 10% by weight into a salicylic acid-based poly (anhydride-ester) (SA-based PAE) was developed as an adjunct treatment for periodontal disease. The SA-based PAE/antimicrobial blends were characterized by multiple methods, including contact angle measurements and differential scanning calorimetry. Static contact angle measurements showed no significant differences in hydrophobicity between the polymer and antimicrobial matrix surfaces. Notable decreases in the polymer glass transition temperature (T(g)) and the antimicrobials' melting points (T(m)) were observed indicating that the antimicrobials act as plasticizers within the polymer matrix. In vitro drug release of salicylic acid from the polymer matrix and for each physically admixed antimicrobial was concurrently monitored by high pressure liquid chromatography during the course of polymer degradation and erosion. Although the polymer/antimicrobial blends were immiscible, the initial 24 h of drug release correlated to the erosion profiles. The SA-based PAE/antimicrobial blends are being investigated as an improvement on current localized drug therapies used to treat periodontal disease.
Johnson
Michelle L
ML
Department of Chemistry and Chemical Biology, Rutgers University, 610 Taylor Road, Piscataway, New Jersey 08854-8087, USA.
Uhrich
Kathryn E
KE
D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004952:Esters; D006863:Hydrogen-Ion Concentration; D008956:Models, Chemical; D049388:Polyanhydrides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D020156:Salicylic Acid / Q000737:chemistry*; D012995:Solubility; D013696:Temperature; D013997:Time Factors; D014867:Water / Q000737:chemistry
D000890:Anti-Infective Agents; D004337:Drug Carriers; D004952:Esters; D049388:Polyanhydrides; D011108:Polymers; D014867:Water; D020156:Salicylic Acid