Antimicrobial activity of some thiourea derivatives and their nickel and copper complexes.
Five thiourea derivative ligands and their Ni(2+) and Cu(2+) complexes have been synthesized. The compounds were screened for their in vitro anti-bacterial activity using Gram-positive bacteria (two different standard strains of Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, Streptococcus pyogenes, Bacillus cereus) and Gram-negative bacteria (Esherichia coli, Pseudomonas aeruginosa, Enterobacter cloacae, Proteus vulgaris, Enterobacter aerogenes) and in vitro anti-yeast activity (Candida albicans, Candida krusei, Candida glabrata, Candida tropicalis, Candida parapsilosis). The minimum inhibitory concentration was determined for all ligands and their complexes. In vitro anti-yeast activity of both ligands and their metal complexes is greater than their in vitro anti-bacterial activity. The effect of the structure of the investigated compounds on the antimicrobial activity is discussed.
Arslan
Hakan
H
Department of Natural Sciences, Fayetteville State University, Fayetteville, NC 28301, USA. hakan.arslan.acad@gmail.com
Duran
Nizami
N
Borekci
Gulay
G
Koray Ozer
Cemal
C
Akbay
Cevdet
C
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D013890:Thiourea / Q000737:chemistry / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
D000890:Anti-Infective Agents; D003300:Copper; D009532:Nickel; D013890:Thiourea