No association of lipase C polymorphisms with Alzheimer's disease.
Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism. As such this link makes LIPC a potential functional candidate for AD risk. Previously, three single nucleotide polymorphisms (SNPs) have been investigated in AD with a lack of association reported. To rule out a possible contribution of other variants in LIPC, located at 15q21-q23, we used a detailed fine mapping approach in a German case-control sample. Genotyping of 25 single nucleotide polymorphisms covering the complete LIPC gene and haplotypic analysis revealed no association with AD. Thus, we conclude that LIPC can be excluded as a major functional candidate gene conferring risk to AD.
Laws
S M
SM
Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU-München, Munich, Germany. simon.laws@lrz.tu-muenchen.de
Eckart
K
K
Friedrich
P
P
Eisele
T
T
Kurz
A
A
Förstl
H
H
Riemenschneider
M
M
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008049:Lipase / Q000235:genetics*; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D005819:Genetic Markers; C504173:LIPC protein, human; D008049:Lipase