title: Breast cancer with cartilaginous and/or osseous metaplasia.
abstract: We report a rare case of breast cancer with cartilaginous and/or osseous metaplasia. A 59-year-old woman had a large lump in her left breast, which had enlarged gradually over a period of 2 years. Mammography, ultrasonography and aspiration cytology suggested phyllodes tumor with carcinoma. She underwent wide excision and sentinel lymph node biopsy. Because of the existence metastatic tumor cells in the sentinel lymph node on frozen section, sequential axillary lymph node dissection was conducted consequently. Histologically, the tumor consisted of invasive ductal carcinoma and spindle-cell carcinoma, including cartilaginous metaplasia. Adjuvant chemotherapy and whole-breast irradiation were performed. However, she died of multiple metastases to the liver 2 years after surgery. Breast cancer with cartilaginous and/or osseous metaplasia belongs to a special type of invasive carcinoma, and the incidence is very low. We here present our case and a review of the literature.
authors.affiliation: Department of General Surgery, Chiba University Graduate School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba 260-0856, Japan. yoitaku@graduate.chiba-u.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Yoichi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagashima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yagata
authors.forename: Kazuya
authors.initials: K
authors.lastname: Yoshida
authors.forename: Masato
authors.initials: M
authors.lastname: Suzuki
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Fujimori
authors.forename: Takafumi
authors.initials: T
authors.lastname: Sangai
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyazaki
mesh_terms: D001842:Bone and Bones / Q000473:pathology; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D002356:Cartilage / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008408:Mastectomy; D008679:Metaplasia / Q000473:pathology*; D008875:Middle Aged; D003557:Phyllodes Tumor / Q000473:pathology* / Q000601:surgery; D021701:Sentinel Lymph Node Biopsy