Sclerosing angiomatoid nodular transformation of the spleen: case report.
Sclerosing angiomatoid transformation of the spleen (SANT) is a relatively new, rare, and unique lesion that involves the spleen. Less than 30 cases have been described to date. The lesion commonly affects middle-aged adults and shows a female predilection. It is often discovered incidentally through imaging. SANT is morphologically and immunohistochemically distinct. However, as it is a relatively new entity, misdiagnosis of SANT may lead to overtreatment of the patients. The pathogenesis of SANT is unknown. The lesion is entirely benign, and splenectomy is curative. We report a new case of SANT, with emphasis on the differential diagnosis and pathogenesis of SANT.
El Demellawy
Dina
D
Northern Ontario School of Medicine, William Osler Health Care, Pathology and Laboratory Medicine, 2301 Salcome Drive, Oakville, Ontario, Canada. dina.demellawy@sympatico.ca
Nasr
Ahmed
A
Alowami
Salem
S
D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications; D005260:Female; D006391:Hemangioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000150:complications; D008875:Middle Aged; D013154:Spleen / Q000098:blood supply / Q000473:pathology; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery