[Effects of penetration enhancers on percutaneous permeability of geniposide in Xiao'er Ninhuang tuire cataplasms].
OBJECTIVE
To investigate the different permeation enhancers on the transdermal permeation of Xiao'er Niuhuang tuire cataplasms (XNTC).


METHODS
Using improved franz-type diffusion cell with excised rat skin in vitro as the transdermal barrier, the content of permeated geniposide was determined by HPLC to study the kinetic parameters such as cumulative permeation quantity and permeation rate.


RESULTS
The result showed that the process of penetrating of geniposide in XNTC through skin could be in accordance with zero-rade releasing equation and XNTC was stable during the course of experiment.


CONCLUSIONS
5% Propylene glycol (PG)-azone (2:3) has the best permeation-enhancing effect, and the results provided a primary basis for the future research on Xiao'er Niuhuang tuire cataplasms.
Shi
Zhao-Hua
ZH
Hubei Engineering Technology Centre of Modernization of Traditional Chinese Medicine, Wuhan 430052, China. szhlww2006@163.com
Xiong
Fu-Liang
FL
Huang
Zhi-Jun
ZJ
Xiong
Deng-Ke
DK
Zeng
Qing-Hui
QH
D000818:Animals; D001381:Azepines / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D066298:In Vitro Techniques; D039823:Iridoids / Q000737:chemistry*; D014677:Pharmaceutical Vehicles / Q000494:pharmacology*; D019946:Propylene Glycol / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012869:Skin Absorption / Q000187:drug effects*
D001381:Azepines; D004365:Drugs, Chinese Herbal; D039823:Iridoids; D014677:Pharmaceutical Vehicles; C007835:geniposide; C035229:laurocapram; D019946:Propylene Glycol