Hypovitaminosis D and secondary hyperparathyroidism in resident physicians of a general hospital in southern Brazil.
OBJECTIVE
To evaluate the prevalence of hypovitaminosis D and secondary hyperparathyroidism in resident physicians of a general hospital in southern Brazil and identify associated factors.


METHODS
Cross-sectional study.


METHODS
Resident physicians of Hospital de Clinicas de Porto Alegre, Porto Alegre, southern Brazil.


METHODS
Seventythree subjects age 26.4+/-1.9.


METHODS
Serum PTH, 25- hydroxyvitamin D [25(OH)D], total calcium, phosphorus, magnesium, creatinine, and alkaline phosphatase were measured. In addition calcium, creatinine, and magnesium were measured in urine. Fractional excretion of calcium and magnesium were calculated. Calcium intake was estimated by a food intake questionnaire.


RESULTS
Mean serum levels of 25(OH)D were 17.9+/-8.0 ng/ml and 57.4% presented 25(OH)D below 20 ng/ml. Secondary hyperparathyroidism, defined as serum PTH > or =48 pg/ml and normal or low serum calcium, was identified in 39.7% of the individuals. Mean serum levels of magnesium were higher (p=0.02) and the fractional excretion of calcium was lower (p<0.001) in individuals with secondary hyperparathyroidism. Serum PTH levels were positively correlated with body mass index (r=0.33 and p=0.006) and serum magnesium levels (r=0.33 and p=0.02) and negatively correlated with serum 25(OH)D levels (r=-0.33 and p=0.008), estimated calcium intake (r=-0.25 and p=0.04), and fractional excretion of calcium (r=-0.34 and p=0.009).


CONCLUSIONS
Vitamin D deficiency and secondary hyperparathyroidism was very common in resident physicians. Therefore, measures to prevent this situation should be recommended.
Premaor
M O
MO
Internal Medicine Service, Hospital de Clínicas de Porto Alegre, HCPA, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. mopremaor@bol.com.br
Paludo
P
P
Manica
D
D
Paludo
A P
AP
Rossatto
E R
ER
Scalco
R
R
Furlanetto
T W
TW
D000328:Adult; D015992:Body Mass Index; D001938:Brazil / Q000453:epidemiology; D002118:Calcium / Q000097:blood / Q000652:urine; D002136:Calcium, Dietary / Q000008:administration & dosage; D003430:Cross-Sectional Studies; D005260:Female; D006769:Hospitals, General; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000453:epidemiology*; D007396:Internship and Residency; D008274:Magnesium / Q000097:blood; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood*; D015995:Prevalence; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology*
D002136:Calcium, Dietary; D010281:Parathyroid Hormone; D014807:Vitamin D; C104450:25-hydroxyvitamin D; D008274:Magnesium; D002118:Calcium