Magnetic tagging of therapeutic cells for MRI.
Transplantation of stem cells or immune cells has shown promise for the treatment of several diseases. Monitoring magnetically labeled cells with MRI has furthered our understanding of cellular migration and the pathophysiology of diseases in experimental models. These studies should pave the way for guiding clinical trials using cell-based therapies. This review briefly describes the various methods used to label and track cells with MRI and the potential for such methods to translate to human applications.
Budde
Matthew D
MD
Radiology and Imaging Sciences, National Institutes of Health Clinical Center, Bethesda, Maryland 20892, USA. buddem@cc.nih.gov
Frank
Joseph A
JA
D000818:Animals; D003287:Contrast Media; D005290:Ferric Compounds; D005466:Fluorocarbons; D005682:Gadolinium; D017930:Genes, Reporter; D006801:Humans; D007107:Immune System / Q000166:cytology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D053768:Metal Nanoparticles; D033581:Stem Cell Transplantation; D019737:Transplants
D003287:Contrast Media; D005290:Ferric Compounds; D005466:Fluorocarbons; C000499:ferric oxide; D005682:Gadolinium