Flavonoid and a rare benzophenone glycoside from the leaves of Aquilaria sinensis.
From the leaves of Aquilaria sinensis (LOUR.) GILG, a novel benzophenone glucoside, designated as aquilarinoside A (1), and a new flavonoid, as 7-beta-D-glucoside of 5-O-methylapigenin (2), along with eight known compounds (3-10) were isolated. The structures of 1 and 2 were fully characterized by spectroscopic methods (1D, 2D NMR and MS) and the relative stereochemistry was assigned based on nuclear Overhauser effect spectroscopy (NOESY) correlations and analyses of coupling constants. The new compounds showed inhibition activity against polymorphonuclear neutrophils (PMNs) respiratory burst stimulated by PMA.
Qi
Jin
J
Department of Complex Prescription of TCM, China Pharmaceutical University, Nanjing, P.R. China.
Lu
Jing-Jing
JJ
Liu
Ji-Hua
JH
Yu
Bo-Yang
BY
D000818:Animals; D001577:Benzophenones / Q000737:chemistry* / Q000302:isolation & purification; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D006868:Hydrolysis; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D016897:Respiratory Burst / Q000187:drug effects; D021241:Spectrometry, Mass, Electrospray Ionization; D029645:Thymelaeaceae / Q000737:chemistry*
C539042:5-O-methylapigenin, 7-beta-D-glucoside; D001577:Benzophenones; D005419:Flavonoids; D005960:Glucosides; C539041:aquilarinoside A