title: Treatment of refractory pyoderma gangrenosum with intravenous immunoglobulin.
abstract: We report a patient with pyoderma gangrenosum successfully treated with intravenous immunoglobulin. He had previously been treated for 4 years with high-dose corticosteroids and had developed insulin-dependent diabetes mellitus. Multiple corticosteroid-sparing agents had failed or were contraindicated. He developed no adverse effects from intravenous immunoglobulin, which allowed reduction of his prednisone to 3 mg/day, and his ulcer has completely healed.
authors.affiliation: Department of Dermatology, Royal Prince Alfred Hospital, New South Wales, Australia. sallydz@hotmail.com
authors.forename: Sally E
authors.initials: SE
authors.lastname: de Zwaan
authors.forename: Harry J
authors.initials: HJ
authors.lastname: Iland
authors.forename: Diona L
authors.initials: DL
authors.lastname: Damian
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000139:chemically induced / Q000150:complications; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000627:therapeutic use*; D007871:Leg Ulcer / Q000188:drug therapy*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors