N-->S acyl-transfer-mediated synthesis of peptide thioesters using anilide derivatives.
N-->S acyl-transfer-mediated synthesis of peptide thioesters utilizing an N-aminoacyl-N-sulfanylethylaminobenzoic acid derivative has been examined. The developed synthetic methodology for peptide thioesters is compatible with Fmoc solid-phase peptide synthesis (SPPS).
Tsuda
Shugo
S
Institute of Health Biosciences and Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770-8505, Japan.
Shigenaga
Akira
A
Bando
Kiyomi
K
Otaka
Akira
A
D000813:Anilides / Q000737:chemistry*; D004952:Esters; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry
D000813:Anilides; D004952:Esters; D010455:Peptides; D013455:Sulfur; D009584:Nitrogen