Corticosteroid receptors, macrophages and cardiovascular disease.
The mineralocorticoid receptor (MR) and glucocorticoid receptor are ligand-activated transcription factors that have important physiological and pathophysiological actions in a broad range of cell types including monocytes and macrophages. While the glucocorticoids cortisol and corticosterone have well-described anti-inflammatory actions on both recruited and tissue resident macrophages, a role for the mineralocorticoid aldosterone in these cells is largely undefined. Emerging evidence, however, suggests that MR signalling may promote pro-inflammatory effects. This review will discuss the current understanding of the role of corticosteroid receptors in macrophages and their effect on diseases involving inflammation, with a particular focus on cardiovascular disease.
Rickard
Amanda J
AJ
Prince Henry's Institute of Medical Research, Victoria, Australia. amanda.rickard@princehenrys.org
Young
Morag J
MJ
D002318:Cardiovascular Diseases / Q000503:physiopathology*; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D018161:Receptors, Mineralocorticoid / Q000502:physiology*
D011965:Receptors, Glucocorticoid; D018161:Receptors, Mineralocorticoid