title: Reduced mania and depression in juvenile bipolar disorder associated with long-chain omega-3 polyunsaturated fatty acid supplementation.
abstract: Long-chain omega-3 polyunsaturated fatty acid (LCn-3PUFA) supplementation may improve symptoms of depression in children and bipolar disorder (BD) in adults. No studies have examined the effectiveness of LCn-3PUFA supplementation in the treatment of mania and depression in juvenile BD (JBD) when given as an adjunct to standard pharmacological treatment. Eighteen children and adolescents with JBD received supplements containing 360 mg per day eicosapentaenoic acid (EPA) and 1560 mg per day docosahexaenoic acid (DHA) for 6 weeks in an open-label study. Intake and fasting red blood cell (RBC) LCn-3PUFA, mania, depression and global function were assessed before and after supplementation. RBC EPA and DHA were significantly higher following supplementation. Clinician ratings of mania and depression were significantly lower and global functioning significantly higher after supplementation. Parent ratings of internalizing and externalizing behaviours were also significantly lower following supplementation. A larger randomized controlled trial appears warranted in this participant population.
authors.affiliation: NSW Department of Primary Industries, Wagga Wagga Agricultural Institute, Wagga Wagga, New South Wales, Australia. edward.clayton@dpi.nsw.gov.au
authors.forename: E H
authors.initials: EH
authors.lastname: Clayton
authors.forename: T L
authors.initials: TL
authors.lastname: Hanstock
authors.forename: S J
authors.initials: SJ
authors.lastname: Hirneth
authors.forename: C J
authors.initials: CJ
authors.lastname: Kable
authors.forename: M L
authors.initials: ML
authors.lastname: Garg
authors.forename: P L
authors.initials: PL
authors.lastname: Hazell
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000187:drug effects; D000928:Antidepressive Agents / Q000627:therapeutic use*; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015118:Eicosapentaenoic Acid / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005395:Fish Oils / Q000627:therapeutic use; D006801:Humans; D008297:Male
chemical_list: D000928:Antidepressive Agents; D018692:Antimanic Agents; D005395:Fish Oils; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid