title: The effect of metoclopramide in capsule enteroscopy.
abstract: Clinical utility of prokinetics in capsule endoscopy (CE) is not clearly established. The objective of this prospective, randomized, single-blind, controlled trial was to determine if metoclopramide is useful in CE by increasing the rate of complete enteroscopy. Ninety-five patients referred for CE were randomized to no metoclopramide (group B, n = 48) or 10 mg metoclopramide (group A, n = 47). Complete enteroscopy was possible in 38 patients of group A (80.9%) and 37 of group B (77.1%) (P = 0.422) with two cases of gastric retention in group B (4.2%; P = 0.253). Median gastric transit time was 26 min (1-211) in group A and 28 min (4-200) in group B (P = 0.511). Mean small bowel transit time, calculated after excluding 20 patients with incomplete enteroscopy, was similar in both groups (221.2 +/- 89 min vs. 256 +/- 82.2 min; P = 0.083). There were also no differences in the total number of findings (group A 4.5 +/- 4.7; group B 4.7 +/- 3.7, P = 0.815). Administration of 10 mg metoclopramide orally 15 min before capsule ingestion did not significantly increase the rate of total enteroscopies and had no effect on transit times. It also did not modify CE diagnostic yield.
authors.affiliation: Department of Gastroenterology, Coimbra University Hospital, Praceta Mota Pinto e Av Bissaya Barreto, Coimbra 3000-075, Portugal. nunoperesalmeida@gmail.com
authors.forename: Nuno
authors.initials: N
authors.lastname: Almeida
authors.forename: Pedro
authors.initials: P
authors.lastname: Figueiredo
authors.forename: Paulo
authors.initials: P
authors.lastname: Freire
authors.forename: Sandra
authors.initials: S
authors.lastname: Lopes
authors.forename: Clotilde
authors.initials: C
authors.lastname: Lérias
authors.forename: Hermano
authors.initials: H
authors.lastname: Gouveia
authors.forename: Maximino Correia
authors.initials: MC
authors.lastname: Leitão
mesh_terms: D000284:Administration, Oral; D053704:Capsule Endoscopy; D018492:Dopamine Antagonists / Q000008:administration & dosage*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D011292:Premedication; D016037:Single-Blind Method
chemical_list: D018492:Dopamine Antagonists; D008787:Metoclopramide