title: [Factors influencing the long-term survival in pancreatic carcinoma patients after radical resection].
abstract: OBJECTIVE
  To investigate the factors influencing the long-term survival of pancreatic carcinoma patients after radical resection.
  
  
  METHODS
  The data of 184 pancreatic carcinoma patients with radical resection were analyzed retrospectively. Analysis of the prognostic factors influencing the long-term survival was performed using Cox proportional hazard regression model.
  
  
  RESULTS
  The overall 1-, 3- and 5-year survival rates in this group were 61.7%, 29.0% and 14.3%, respectively. They were 78.0%, 38.4% and 25.7%, respectively, for the patients with a tumor < 3 cm in diameter, significantly better than those with a tumor >or= 3 cm (52.8%, 22.7% and 7.2%, respectively, P < 0.05). Moreover, the 1-, 3- and 5-year survival rates were 67.6%, 30.5% and 17.4%, respectively, in the patients without lymph node involvement, much longer than that in those with lymph node metastasis (37.1%, 20.6% and 0, respectively, P < 0.05). Multivariate analysis by Cox proportional hazard regression model revealed that the tumor size (P < 0.05) and lymph node metastasis (P < 0.01) significantly influenced the long-term survival of the patients.
  
  
  CONCLUSIONS
  Tumor size and lymph node metastasis are significant factors influencing the long-term survival of pancreatic carcinoma patients with radical resection. Therefore, early diagnosis and radical resection are the key points to improve treatment outcome.
authors.affiliation: Department of General Surgery, The First Hospital, Wenzhou Medical College, Wenzhou 325000, China. zwj10095@sohu.com
authors.forename: Wei-jian
authors.initials: WJ
authors.lastname: Zhang
authors.forename: Shao-liang
authors.initials: SL
authors.lastname: Han
authors.forename: Fei-zhao
authors.initials: FZ
authors.lastname: Jiang
authors.forename: Heng-liang
authors.initials: HL
authors.lastname: Zhu
authors.forename: Bai-liang
authors.initials: BL
authors.lastname: Ye
authors.forename: Qing-hong
authors.initials: QH
authors.lastname: Ke
authors.forename: Yao
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000473:pathology / Q000601:surgery*; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate; D047368:Tumor Burden; D055815:Young Adult