title: [Success and failure predictors of non-invasive ventilation in acute bronchiolitis].
abstract: BACKGROUND
  The objective was to identify predictive factors for non-invasive ventilation (NIV) failure and to describe its use in bronchiolitis.
  
  
  METHODS
  Prospective observational study that included patients diagnosed with bronchiolitis with a modified Wood's Clinical Asthma Score 5, or oxygen saturation <92%, or venous CO(2) partial pressure (PCO(2)) 60 mm Hg, with no response to medical treatment, who received NIV from December 2005 to May 2008. We collected clinical data before NIV began and at 1, 6, 12, 24 and 48 h. Need for intubation was considered as NIV failure.
  
  
  RESULTS
  NIV was successful in 83% of 47 cases included. Patients in whom NIV failed had lower weight (5.2+/-2.2 vs. 3.5+/-0.8 kg, P=.011), lower age [1.8 (0.3-12.3) vs. 0.8 (0.4-4.3) months, P=.038)], lower heart rate (HR) before NIV began (176.3+/-19.1 vs. 160.4+/-9.7 beats/minute, P=.010), lower HR decrease at hours 1 (-16.0+/-17.3 vs.+1.1+/-11.6, P=.005) and 12 (-31.5+/-19.7 vs. -0.75+/-12.2, P=.002), presence of apnoeas (23.1% vs. 75%; P=.004) and of a predisposing condition (84.6% vs. 50%; P=.029). Multivariate analysis identified the absence of a predisposing condition, and a greater HR decrease during the first hour as success-associated independent factors (OR 0.004; 95% CI 0.000-0.664 and OR 0.896; 95% CI: 0.809-0.993, respectively).
  
  
  CONCLUSIONS
  NIV has a high success rate in bronchiolitis. The main parameters which can predict NIV success are the absence of a predisposing condition and a higher HR decrease in the first hour.
authors.affiliation: Sección de Cuidados Intensivos Pediátricos, Hospital Universitario Central de Asturias, Oviedo, España. jmcolunga@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Mayordomo-Colunga
authors.forename: A
authors.initials: A
authors.lastname: Medina
authors.forename: C
authors.initials: C
authors.lastname: Rey
authors.forename: M
authors.initials: M
authors.lastname: Los Arcos
authors.forename: A
authors.initials: A
authors.lastname: Concha
authors.forename: S
authors.initials: S
authors.lastname: Menéndez
mesh_terms: D000208:Acute Disease; D001988:Bronchiolitis / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods; D016896:Treatment Outcome