title: Polymorphic Alu insertions and their associations with MHC class I alleles and haplotypes in Han and Jinuo populations in Yunnan Province, southwest of China.
abstract: The associations of polymorphic Alu insertions (POALINs) with major histocompatibility complex (MHC) class I genes enable us to better identify origins and evolution of MHC class I region haplotypes in different populations. For further studying origins and evolution of MHC class I region haplotypes in Han and Jinuo populations in Yunnan Province, we investigated frequencies of five POALINs, their associations with HLA-A and -B, the three-loci POALINs haplotype frequencies and HLA/POALIN four-loci haplotype frequencies within the alpha block of MHC class I region. We found that a strong positive association between AluHG and HLA-A*02 is in Jinuo, but not in Yunnan Han. These results suggest that MHC class I region haplotypes of the two studied populations might derive from different progenitor haplotypes and MHC I-POALINs are informative genetic markers for investigating origins and evolution of MHC class I region haplotypes in different populations.
authors.affiliation: Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China.
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Yao
authors.forename: Li
authors.initials: L
authors.lastname: Shi
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Keqin
authors.initials: K
authors.lastname: Lin
authors.forename: Yufen
authors.initials: Y
authors.lastname: Tao
authors.forename: Liang
authors.initials: L
authors.lastname: Yu
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Huang
authors.forename: Yanhan
authors.initials: Y
authors.lastname: Li
authors.forename: Jiayou
authors.initials: J
authors.lastname: Chu
mesh_terms: D000483:Alleles; D020087:Alu Elements / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D005805:Genes, MHC Class I / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D010802:Phylogeny; D011110:Polymorphism, Genetic
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens