title: Mean platelet volume in patients with slow coronary flow and its relationship with clinical presentation.
abstract: OBJECTIVE
  We investigated mean platelet volume (MPV) in patients with slow coronary flow (SCF) and its possible relationship with clinical presentation.
  
  
  METHODS
  The study included 50 patients with SCF and otherwise normal coronary arteries and 22 patients (control group) with normal coronary arteries. In the SCF group, there were 26 patients with stable angina pectoris (SAP), and 24 patients with unstable angina pectoris (USAP). Coronary blood flow was measured using the TIMI frame count. To determine MPV, blood samples with K3 EDTA were processed after one hour of venipuncture. The relationship between MPV and SCF was sought.
  
  
  RESULTS
  The mean TIMI frame count was markedly increased in patients with SCF compared to controls (p<0.0001). No significant differences existed between the groups with regard to white blood cell and platelet counts. Patients with SCF had significantly higher MPV values compared to controls (9.4+/-2.3 fl vs 8.1+/-2.0 fl, p=0.014). In subgroup analysis, MPV was significantly increased only in patients presenting with USAP, compared to patients with SAP (p=0.044) and controls (p=0.002). There was a positive correlation between the mean TIMI frame count and MPV in patients with SCF (r=0.32, p=0.01). In multivariate analysis, MPV was the only independent predictor of SCF (p=0.006, odds ratio=1.305, 95% CI=0.985-1.730).
  
  
  CONCLUSIONS
  Our findings show that MPV is increased in patients with SCF, and SCF patients presenting with USAP exhibit significantly increased MPV values, suggesting an altered platelet reactivity and aggregation which may require effective anti-platelet therapy in this patient subgroup.
authors.affiliation: Department of Cardiology, Siyami Ersek Cardiovascular Surgery Center, Istanbul, Turkey. zeknurkalem@yahoo.com
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Nurkalem
authors.forename: Ahmet T
authors.initials: AT
authors.lastname: Alper
authors.forename: Ahmet L
authors.initials: AL
authors.lastname: Orhan
authors.forename: Aycan E
authors.initials: AE
authors.lastname: Zencirci
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sari
authors.forename: Betül
authors.initials: B
authors.lastname: Erer
authors.forename: Hale U
authors.initials: HU
authors.lastname: Aksu
authors.forename: Dilek S
authors.initials: DS
authors.lastname: Ergün
authors.forename: Hale Y
authors.initials: HY
authors.lastname: Yilmaz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Eren
mesh_terms: D000787:Angina Pectoris / Q000097:blood* / Q000000981:diagnostic imaging; D000789:Angina, Unstable / Q000097:blood* / Q000000981:diagnostic imaging; D001783:Blood Flow Velocity / Q000502:physiology*; D001792:Blood Platelets; D016022:Case-Control Studies; D016001:Confidence Intervals; D017023:Coronary Angiography; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010976:Platelet Count; D011237:Predictive Value of Tests; D012039:Regional Blood Flow; D013922:Thrombocytosis / Q000097:blood* / Q000000981:diagnostic imaging