title: [HIV-1 genetic variability in non Spaniard infected children].
abstract: BACKGROUND
  The prevalence of HIV-1 non-B subtypes (HIV-NBS) is increasing in Europe, because of emigration from countries where genetic variants are endemic. Although HIV-NBS could have a different clinical evolution and could respond differently to antiretrovirals (AR) than B-subtypes, these variant's response remain undocumented.
  
  
  OBJECTIVE
  To identify HIV-1 genetic variants and to determine clinical evolution in a non-Spaniard children infected with HIV-1.
  
  
  METHODS
  Children with HIV-1 infection from endemic countries were tested for HIV-1 subtypes between 1-1-1988 and 31-12-2006. Twelve children less than 18 years old and born abroad were selected.
  
  
  RESULTS
  HIV-NBS were isolated in 5 children (42%): CRF2_AG recombinant in 3 cases (Equatorial Guinea), Subtype C in one (Equatorial Guinea) and CRF13_cpx in last one (India).
  
  
  CONCLUSIONS
  Because of the increasing frequency of patients with HIV-NBS and their unknown long-term evolution, all children from endemic countries should be tested for HIV subtypes. We believe new studies with more patients during longer times could reveal differences in these patient's clinical, immunological and virological evolution.
authors.affiliation: Servicio de Pediatría, Hospital Carlos III, Madrid, España. roipineiro@telefonica.net
authors.forename: R
authors.initials: R
authors.lastname: Piñeiro Pérez
authors.forename: M J
authors.initials: MJ
authors.lastname: Mellado Peña
authors.forename: A
authors.initials: A
authors.lastname: Holguín
authors.forename: M J
authors.initials: MJ
authors.lastname: Cilleruelo
authors.forename: M
authors.initials: M
authors.lastname: García Hortelano
authors.forename: J
authors.initials: J
authors.lastname: Villota
authors.forename: P
authors.initials: P
authors.lastname: Martín Fontelos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D014644:Genetic Variation; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D014171:Transients and Migrants