title: Kainic acid intraocular injections during the postnatal critical period induce plastic changes in the visual system.
abstract: Changes in the retino-collicular projection and in the number of optic nerve (ON) axons in adult rats were analyzed after partial loss of retinal ganglion cells (RGCs), induced by intravitreal injections of kainic acid (KA) on postnatal days 2-3 (P2-P3) or 10-12 (P10-P12). KA injected at P2-P3 decreased the volume of the adult contralateral superior colliculus (SC) and the density of the retino-collicular contralateral projection, but maintained the neonatal pattern in the ipsilateral projection from the un-injected eye. ON axon number was significantly increased in the un-injected eye but decreased in the KA-injected eye. Thus, restriction of the ipsilateral retino-collicular projection and RGC death in the un-injected eye are modified by KA at P2-P3, during the postnatal critical period, but not at P10-P12, after it is over. We suggest that, in the SC contralateral to the KA-injected eye, the disappearance of axon terminals belonging to RGC killed by KA would decrease competition between ipsilateral and contralateral terminals, thus contributing to maintaining the neonatal pattern in the ipsilateral retino-collicular projection. The reduction in RGC death in the un-injected eye could also be related to the disappearance of RGC terminals in the contralateral SC, which would have increased neurotrophic factor availability.
authors.affiliation: Department of Ophthalmology, University Hospital Prince of Asturias, Spain. cinta.perezrico@gmail.com
authors.forename: Consuelo
authors.initials: C
authors.lastname: Pérez-Rico
authors.forename: Pedro
authors.initials: P
authors.lastname: de la Villa
authors.forename: Fernando
authors.initials: F
authors.lastname: Reinoso-Suárez
authors.forename: Pilar
authors.initials: P
authors.lastname: Gómez-Ramos
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology*; D007839:Functional Laterality / Q000187:drug effects / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology*; D009410:Nerve Degeneration / Q000139:chemically induced; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D009900:Optic Nerve / Q000187:drug effects / Q000254:growth & development; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000502:physiology; D013477:Superior Colliculi; D014795:Visual Pathways / Q000166:cytology / Q000187:drug effects / Q000254:growth & development
chemical_list: D018690:Excitatory Amino Acid Agonists; D007608:Kainic Acid