Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor.
The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERalpha interacts with the signaling of IGF-1 receptor in neural cells: ERalpha transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERalpha and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel, ERalpha and IGF-I receptor.
Marin
Raquel
R
Laboratory of Cellular Neurobiology, Department of Physiology & Institute of Biomedical Technologies, University of La Laguna, School of Medicine, Santa Cruz de Tenerife, Spain.
Díaz
Mario
M
Alonso
Rafael
R
Sanz
Amaya
A
Arévalo
María Angeles
MA
Garcia-Segura
Luis M
LM
D000818:Animals; D001921:Brain / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D047628:Estrogen Receptor alpha; D017526:Receptor, IGF Type 1