[Management of phosphate in chronic kidney disease--Regulation of posphate homeostasis].
Inorganic phosphate (Pi) is an essential nutrient in terms of both cellular metabolism and skeletal mineralization. Dietary Pi is absorbed by the intestine, deposited in the bone and filtered by the kidney. Regulation of Pi absorption/reabsorption is achieved by changing the apical abundance of Na/Pi transporters (NaPi- II a, II b, and II c) . The regulatory mechanisms involve several signaling factors, such as parathyroid hormone (PTH) , 1,25 (OH)2D3, and fibroblast growth factor (FGF) -23. FGF-23, produced in the osteocytes, binds with FGF receptor (FGFR) and klotho in target organs (kidney or parathyroid grand et al.) and acts as a Pi regulating factor.
Segawa
Hiroko
H
The University of Tokushima Graduate School, Institution of Health Biosciences, Department of Molecular Nutrition.
Miyamoto
Ken-ichi
K
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D002117:Calcitriol / Q000502:physiology; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000502:physiology; D005966:Glucuronidase / Q000502:physiology; D006706:Homeostasis / Q000235:genetics; D006801:Humans; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D000090265:Klotho Proteins; D010281:Parathyroid Hormone / Q000502:physiology; D010710:Phosphates / Q000378:metabolism*; D017468:Receptors, Fibroblast Growth Factor / Q000502:physiology; D050608:Sodium-Phosphate Cotransporter Proteins / Q000502:physiology*
C000717427:FGF23 protein, human; D010281:Parathyroid Hormone; D010710:Phosphates; D017468:Receptors, Fibroblast Growth Factor; D050608:Sodium-Phosphate Cotransporter Proteins; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D005966:Glucuronidase; D000090265:Klotho Proteins; D002117:Calcitriol