title: Idiopathic chondrolysis condition in two young, wild-caught Cynomolgus monkeys (Macaca fascicularis) reared in captivity.
abstract: Idiopathic chondrolysis is a human clinical entity typically reported in adolescent individuals. In this brief communication, we report 2 cases of presumptive idiopathic chondrolysis of the femoral head in Cynomolgus macaques and discuss the clinical symptomatology and pathology of the disease. In detail, we describe the histomorphologic changes of idiopathic chondrolysis and compare these findings with those typically observed in the primary differential diagnoses of Legg-Calve-Perthes disease and nonspecific osteoarthritis. Consideration of this entity among differential diagnoses in young Cynomolgus macaques with unilateral osteoarthritis could be important both for laboratory animal veterinarians and pathologists.
authors.affiliation: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. srao1@mail.nih.gov
authors.forename: S
authors.initials: S
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Bryant
authors.forename: R
authors.initials: R
authors.lastname: Herbert
authors.forename: N
authors.initials: N
authors.lastname: Sullivan
authors.forename: C
authors.initials: C
authors.lastname: Murray
authors.forename: J
authors.initials: J
authors.lastname: Bacher
authors.forename: N
authors.initials: N
authors.lastname: Safdar
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002357:Cartilage Diseases / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000188:drug therapy / Q000473:pathology*; D009288:Naproxen / Q000627:therapeutic use; D015207:Osteoarthritis, Hip / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009288:Naproxen