title: Physiological complexity underlying heart rate dynamics and frailty status in community-dwelling older women.
abstract: OBJECTIVE
  To assess whether less physiological complexity underlying regulation of heart rate dynamics, as indicated by lower approximate entropy for heart rate (ApEn(HR)), is associated with frailty. For supporting validity, relationships between frailty and traditional linear indices of heart rate variability (HRV) were also assessed.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Women's Health and Aging Study I, a community-based observational study, 1992 to 1995.
  
  
  METHODS
  Subset of 389 community-dwelling women aged years and older with moderate to severe disability with ApEn(HR) data (convenience sampling).
  
  
  METHODS
  Electrocardiographic Holter recordings obtained over 2- to 3-hour periods were processed for ApEn(HR) and HRV measures. ApEn(HR) is a nonlinear statistic that quantifies the regularity of heart rate fluctuations over time. Lower ApEn(HR) is characteristic of heart rate time series containing a high proportion of repetitive patterns. Frailty was defined according to validated phenotype criteria.
  
  
  RESULTS
  Median ApEn(HR) was lower in frail than in nonfrail subjects (P=.02). Lower ApEn(HR) (top quartile) was associated with lower likelihood of frailty than higher ApEn(HR) (bottom three quartiles) (odds ratio=0.47, 95% confidence interval=0.26-0.86), even after adjustment for major confounders. Frailty was consistently associated with lower HRV as assessed using time- and frequency-domain indices.
  
  
  CONCLUSIONS
  This study supports the notion that less physiological complexity marks frailty and provides an empirical basis to the concept of frailty as a syndrome of homeostatic impairment. Future research will determine whether noninvasive measures of physiological complexity underlying heart rate dynamics might be useful for screening and monitoring of clinical vulnerability in older adults.
authors.affiliation: Departments of cMedicine and dEpidemiology, Division of Geriatrics Medicine and Gerontology, Center on Aging and Health, Johns Hopkins University, Baltimore, Maryland 21205, USA. pchaves@jhsph.edu
authors.forename: Paulo H M
authors.initials: PH
authors.lastname: Chaves
authors.forename: Ravi
authors.initials: R
authors.lastname: Varadhan
authors.forename: Lewis A
authors.initials: LA
authors.lastname: Lipsitz
authors.forename: Phyllis K
authors.initials: PK
authors.lastname: Stein
authors.forename: B Gwen
authors.initials: BG
authors.lastname: Windham
authors.forename: Jing
authors.initials: J
authors.lastname: Tian
authors.forename: Lee A
authors.initials: LA
authors.lastname: Fleisher
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.forename: Linda P
authors.initials: LP
authors.lastname: Fried
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D015142:Baltimore; D015897:Comorbidity; D003327:Coronary Disease / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D004185:Disability Evaluation; D015716:Electrocardiography, Ambulatory; D019277:Entropy; D005260:Female; D016330:Frail Elderly; D015577:Geriatric Assessment; D006333:Heart Failure / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D006339:Heart Rate / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D016013:Likelihood Functions; D008403:Mass Screening