[Survival/death modifiers of intestine epithelium stem cells and thanatological mechanisms].
Till now the thanatological mechanisms that regulated the proliferation and the clearance of the stem cells (SC) in fast renewal systems of organism--intestinal epithelium remain insufficiently investigated as in haematopoietic system too. The relevance of such researches is supported by an essential role of these mechanisms in pathogenesis of widely widespread inflammatory and hyperproliferative diseases. In particular inhibition/disregulation of elimination for the "undesirable", mutant cells leaving from under immune and own control is one of the reasons for neoplastic cell expansion. In this review were summarized data about some mechanisms determining SC-destruction in animals treated by ionizing radiation or antineoplastic preparations, and also treated by modifiers of SC-radiosensitivity.
Proskuriakov
S Ia
SIa
Konopliannikov
A G
AG
Verkhovskiĭ
Iu G
IuG
Ul'ianova
L P
LP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002470:Cell Survival; D005720:Gamma Rays; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology / Q000502:physiology; D007378:Interleukins / Q000494:pharmacology / Q000502:physiology; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects*; D011836:Radiation Tolerance; D013234:Stem Cells / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects*
D000970:Antineoplastic Agents; D036341:Intercellular Signaling Peptides and Proteins; D007378:Interleukins