1,5-Alpha-D-mannoseptanosides, ring-size isomers that are impervious to alpha-mannosidase-catalyzed hydrolysis.
1,5-D-mannoseptanosyl di- and trisaccharide ring-size isomers of the corresponding mannopyranosyl oligosaccharides have been prepared. Remarkably, these compounds show no inhibition of the alpha-mannosidase-catalyzed hydrolysis of p-nitrophenyl-alpha-D-mannopyranoside.
Boone
Matthew A
MA
Department of Chemistry, Emory University, Atlanta, Georgia 30322, USA.
McDonald
Frank E
FE
Lichter
Joseph
J
Lutz
Stefan
S
Cao
Rui
R
Hardcastle
Kenneth I
KI
D002384:Catalysis; D006868:Hydrolysis; D008362:Mannosides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D043323:alpha-Mannosidase / Q000378:metabolism*
D008362:Mannosides; D009844:Oligosaccharides; D043323:alpha-Mannosidase