Correction of protein metabolic disorders by composite extract of Musa paradisiaca and Coccinia indica in streptozotocin-induced diabetic albino rat: an approach through the pancreas.
OBJECTIVE
The study focused on the ability of the extracts of Musa paradisiaca and Coccinia indica on protein metabolic disorders in streptozotocin (STZ)-induced diabetes.


METHODS
Wistar strain rats were divided into 6 groups as control, control + composite extract treated, STZ-induced diabetes, diabetic + composite extract treated, composite extract-pretreated diabetes, and composite extract-pretreated diabetes + composite extract treated. Protein metabolic status was assessed by serum levels of urea, uric acid, albumin, and creatinine along with urine urea and albumin levels. Diabetic therapeutic ability was assessed by blood glucose, glycated hemoglobin, and serum insulin levels. Histology of the pancreas, liver, and kidney was evaluated.


RESULTS
Indices of protein metabolic disorders were deviated from control in STZ-induced diabetes, which were protected significantly after the treatment of composite extract of M. paradisiaca and C. indica. This protection was more prominent when the extract-pretreated animals were subjected to diabetes induction by STZ.


CONCLUSIONS
The composite extract has a protective therapeutic effect against diabetes through beta-cell regeneration capacity.
Mallick
Chhanda
C
Department of Bio-Medical Laboratory Science and Management, Vidyasagar University, Midnapore, West Bengal, India.
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Debasis
D
Ghosh
Debidas
D
D000581:Amidohydrolases / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D019662:Cucurbitaceae; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000378:metabolism; D029001:Herbal Medicine; D007328:Insulin / Q000097:blood; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007668:Kidney / Q000166:cytology; D008099:Liver / Q000166:cytology; D008297:Male; D008659:Metabolic Diseases / Q000188:drug therapy* / Q000209:etiology; D028521:Musa; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
D000581:Amidohydrolases; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D010936:Plant Extracts; D011506:Proteins; D012709:Serum Albumin; D014508:Urea; D014527:Uric Acid; C019946:creatininase