title: Mass detection on mammograms: influence of signal shape uncertainty on human and model observers.
abstract: We studied the influence of signal variability on human and model observers for detection tasks with realistic simulated masses superimposed on real patient mammographic backgrounds and synthesized mammographic backgrounds (clustered lumpy backgrounds, CLB). Results under the signal-known-exactly (SKE) paradigm were compared with signal-known-statistically (SKS) tasks for which the observers did not have prior knowledge of the shape or size of the signal. Human observers' performance did not vary significantly when benign masses were superimposed on real images or on CLB. Uncertainty and variability in signal shape did not degrade human performance significantly compared with the SKE task, while variability in signal size did. Implementation of appropriate internal noise components allowed the fit of model observers to human performance.
authors.affiliation: University Institute for Radiation Physics, University Hospital Center, and University of Lausanne,CH-1007 Lausanne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Castella
authors.forename: M P
authors.initials: MP
authors.lastname: Eckstein
authors.forename: C K
authors.initials: CK
authors.lastname: Abbey
authors.forename: K
authors.initials: K
authors.lastname: Kinkel
authors.forename: F R
authors.initials: FR
authors.lastname: Verdun
authors.forename: R S
authors.initials: RS
authors.lastname: Saunders
authors.forename: E
authors.initials: E
authors.lastname: Samei
authors.forename: F O
authors.initials: FO
authors.lastname: Bochud
mesh_terms: D001185:Artificial Intelligence; D001943:Breast Neoplasms / Q000000981:diagnostic imaging; D003198:Computer Simulation; D055088:Early Detection of Cancer; D006801:Humans; D008327:Mammography / Q000379:methods*; D015588:Observer Variation; D011857:Radiographic Image Interpretation, Computer-Assisted; D035501:Uncertainty