title: An efficient method for construction of the angularly fused 6,3,5-tricyclic skeleton of mycorrhizin A and its analogues.
abstract: The angularly fused 6,3,5-tricyclic system is readily generated via a cascade cyclization under acid promotion. The reaction proceeds at room temperature with high stereochemical fidelity from the electrophilic center of the epoxide to the cyclopropane product. This methodology provides a potentially useful approach for the synthesis of mycorrhizin A and its analogues.
authors.affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, PR China.
authors.forename: Binxun
authors.initials: B
authors.lastname: Yu
authors.forename: Tuo
authors.initials: T
authors.lastname: Jiang
authors.forename: Weiguo
authors.initials: W
authors.lastname: Quan
authors.forename: Junpeng
authors.initials: J
authors.lastname: Li
authors.forename: Xinfu
authors.initials: X
authors.lastname: Pan
authors.forename: Xuegong
authors.initials: X
authors.lastname: She
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D001688:Biological Products; D003374:Coumarins; C092870:mycorrhizin A