[Prediction for helper T cell epitopes and its application in vaccine development against parasite infection].
Cellular immunity plays an important role in defense against diseases, such as pathogenic infection, autoimmunity and tumor. With the progress of molecular immunology, mechanisms of T cellular immunity, and the T cell epitopes and functional genomics, studies on the prediction based on data-derived for T cell epitopes has been highlighted, and could be one of the useful tools for application in vaccine development. This review summarizes theory and methodology of prediction for helper T cell epitopes, and their application in vaccine development against parasites, and new research directions are also discussed.
Shao
Dong-Hua
DH
Shanghai Research Center for Biotechnology, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai 200232.
Feng
Xin-Gang
XG
D000818:Animals; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D006801:Humans; D010271:Parasites / Q000276:immunology*; D016052:Protozoan Vaccines / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D016052:Protozoan Vaccines