[Structurally functional modifications of the human lymphocytes induced by influence of UV-light].
The influence of UV-light (240-390 nm) in dose 75.5-1510 J/m2 on the structural functional qualities (cytotoxic activity, antibody-produced ability, a level of expression of superficial receptors, a level cAMP) of lymphocytes peripheral blood of donors was investigated. Corregative action of UV-radiation on cytotoxic activity of lymphocytes in relation to cells of Ehrlich ascite carcinoma was revealed. The interrelation of modification types of plasmatic membrane components with a level of functional activity of lymphocytes was established. Was shown, that UV-light induces the decrease in a secondary level of messenger cAMP in cytosol of the photomodified cells. It is revealed, that UV-radiation causes stimulation of antibody-independent mechanism of cytotoxic lymphocytes, which is connected with activation of T-cells and with inhibition of antibody-dependent mechanism of cytotoxic activity.
Artiukhov
V G
VG
Nakvasina
M A
MA
Popova
L I
LI
Trubitsyna
M S
MS
Lidokhova
O V
OV
Sveklo
L S
LS
D000818:Animals; D000917:Antibody Formation; D000954:Antigens, Surface / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects*; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D000242:Cyclic AMP / Q000378:metabolism; D003602:Cytotoxicity, Immunologic / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008213:Lymphocyte Activation; D011836:Radiation Tolerance; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D000954:Antigens, Surface; D000242:Cyclic AMP