title: Intraarterial therapy for acute ischemic strokes.
abstract: OBJECTIVE
  To determine the safety and feasibility of intraarterial stroke therapy for acute ischemic strokes at a community-based medical center.
  
  
  METHODS
  This is a retrospective analysis of data gathered from consecutive stroke patients treated between June 2004 and April 2007. The following therapies were used to treat acute ischemic stroke within 6 hours of symptom onset: intraarterial thrombolytic drugs, intraarterial vasodilators, mechanical clot retrieval, intravascular stents, and angioplasty. The outcomes measured included posttherapy National Institutes of Health Stroke Score (NIHSS), neurologic function at 90 days graded according to the modified Rankin Scale (mRS), recanalization, symptomatic intracranial hemorrhage, and 90-day mortality.
  
  
  RESULTS
  Eighty-three patients with a median baseline NIHSS of 17 (range, 3-30) were treated with intraarterial therapy. The median posttherapy NIHSS was 5 (range, 0-33). Forty-two patients (51%) [corrected] had an mRS score of 2 or less at 90 days. The recanalization rate was 76%. Five patients (6%) had symptomatic intracranial hemorrhage, and the 90-day mortality was 22%.
  
  
  CONCLUSIONS
  The results of this review showed that an intraarterial therapeutic approach to acute ischemic stroke was feasible at a community-based heath center and demonstrated encouraging data for outcome and safety.
authors.affiliation: University of Oklahoma College of Medicine, Oklahoma City, Oklahoma, USA.
authors.forename: Jeffrey G
authors.initials: JG
authors.lastname: Belisle
authors.forename: Vance E
authors.initials: VE
authors.lastname: McCollom
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Tytle
authors.forename: J Mike
authors.initials: JM
authors.lastname: Banowetz
authors.forename: Robert A
authors.initials: RA
authors.lastname: Handley
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Andrezik
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Griggs
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001807:Blood Vessel Prosthesis; D002545:Brain Ischemia / Q000150:complications* / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents; D020521:Stroke / Q000209:etiology* / Q000517:prevention & control*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents