Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.
Ishikawa
Minoru
M
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan.
Ninomiya
Tomohisa
T
Akabane
Hirotomo
H
Kushida
Nobuaki
N
Tsujiuchi
Go
G
Ohyama
Makoto
M
Gomi
Shuichi
S
Shito
Keiko
K
Murata
Takashi
T
D000818:Animals; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D011760:Pyrrolidinones / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D007166:Immunosuppressive Agents; D011760:Pyrrolidinones; C068886:synerazol; D007073:Immunoglobulin E; C012013:pseurotin