title: Increasing adherence to inhaled steroid therapy among schoolchildren: randomized, controlled trial of school-based supervised asthma therapy.
abstract: OBJECTIVE
  We aimed to determine the effectiveness of school-based supervised asthma therapy in improving asthma control. The primary hypothesis was that the supervised-therapy group would have a smaller proportion of children experiencing an episode of poor asthma control each month, compared with those in the usual-care group.
  
  
  METHODS
  Children were eligible if they had physician-diagnosed persistent asthma, the need for daily controller medication, and the ability to use a dry-powder inhaler and a peak flowmeter. The trial used a 2-group, randomized, longitudinal design with a 15-month follow-up period. A total of 290 children from 36 schools were assigned randomly to either school-based, supervised therapy or usual care. Ninety-one percent of the children were black, and 57% were male. The mean age was 11 years (SD: 2.1 years). An episode of poor asthma control was defined as > or =1 of the following each month: (1) an absence from school attributable to respiratory illness/asthma; (2) average use of rescue medication >2 times per week (not including preexercise treatment); or (3) > or =1 red or yellow peak flowmeter reading.
  
  
  RESULTS
  Two hundred forty children completed the study. There were no differences in the likelihood of an episode of poor asthma control between the baseline period and the follow-up period for the usual-care group. For the supervised-therapy group, however, the odds of experiencing an episode of poor asthma control during the baseline period were 1.57 times the odds of experiencing an episode of poor asthma control during the follow-up period. Generalized estimating equation modeling revealed a marginally significant intervention-time period interaction, indicating that children in the supervised-therapy group showed greater improvement in asthma control.
  
  
  CONCLUSIONS
  Supervised asthma therapy improves asthma control. Clinicians who have pediatric patients with asthma with poor outcomes that may be attributable to nonadherence should consider supervised therapy.
authors.affiliation: University of Alabama at Birmingham, Birmingham, Alabama, Lung Health Center, OHB 138, 619 19th St South, Birmingham, AL 35249-7337, USA. geraldl@uab.edu
authors.forename: Lynn B
authors.initials: LB
authors.lastname: Gerald
authors.forename: Leslie A
authors.initials: LA
authors.lastname: McClure
authors.forename: Joan M
authors.initials: JM
authors.lastname: Mangan
authors.forename: Kathy F
authors.initials: KF
authors.lastname: Harrington
authors.forename: Linda
authors.initials: L
authors.lastname: Gibson
authors.forename: Sue
authors.initials: S
authors.lastname: Erwin
authors.forename: Jody
authors.initials: J
authors.lastname: Atchison
authors.forename: Roni
authors.initials: R
authors.lastname: Grad
mesh_terms: D000280:Administration, Inhalation; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance / Q000706:statistics & numerical data*; D012572:School Health Services
chemical_list: D018927:Anti-Asthmatic Agents