Mutagenicity of water-soluble ZnO nanoparticles in Ames test.
A mutagenicity test was conducted on water-soluble ZnO nanoparticles capped with tetramethylammonium hydroxide in a bacterial reverse mutation assay using Salmonella typhimurium strains TA98, TA100, TA1535 and TA1537, and Escherichia coli strain WP2uvrA(-), with and without metabolic activation by S9 mix in the preincubation method. Mutagenicity was negative in all strains.
Yoshida
Rie
R
School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Ashidai, Nomi, Ishikawa 923-1292, Japan.
Kitamura
Daisuke
D
Maenosono
Shinya
S
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D010316:Particle Size; D000644:Quaternary Ammonium Compounds / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D012995:Solubility; D014867:Water; D015034:Zinc Oxide / Q000737:chemistry / Q000633:toxicity*
D009153:Mutagens; D000644:Quaternary Ammonium Compounds; D014867:Water; C027917:tetramethylammonium; D015034:Zinc Oxide