p38delta and PKD1: kinase switches for insulin secretion.
Insufficient production of the hormone insulin by pancreatic beta cells results in diabetes. In this issue, Sumara et al. (2009) report key roles for the protein kinases p38delta and PKD1 in the regulation of insulin secretion as well as in the survival of pancreatic beta cells.
Cuenda
Ana
A
Departamento de Inmunología y Oncología, Centro Nacional de Biotecnología, CSIC, Campus de Cantoblanco, UAM, 28049 Madrid, Spain. acuenda@cnb.csic.es
Nebreda
Angel R
AR
D000818:Animals; D003924:Diabetes Mellitus, Type 2; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000378:metabolism; D051379:Mice; D048292:Mitogen-Activated Protein Kinase 13 / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism*
D007328:Insulin; D048292:Mitogen-Activated Protein Kinase 13; C089212:protein kinase D; D011493:Protein Kinase C