title: [Studies on cyclodextrin inclusion complexes of Dragon's blood and its tablets preparation].
abstract: OBJECTIVE
  To study the cyclodextrin inclusion complexes of Dragon's blood for improving the drug solubility and the preparation.
  
  
  METHODS
  The inclusion complexes were prepared with beta-cyclodextrin, HP-beta-cyclodextrin, SBE-beta-cyclodextrin and confirmed by DTA. The activity of the inclusion complex was tested by animal experiments. Inclusion complexes tablets were prepared and the dissolution test was performed.
  
  
  RESULTS
  The solubility of inclusion complexes was increased to 13. 75-168. 39 times. The activity of the inclusion complex was markedly improved, and dissolution rate was 78.69%.
  
  
  CONCLUSIONS
  The cyclodextrin inclusion complexes of Dragon's blood have a good solubility, dissolution rate and pharmacological activity.
authors.affiliation: Jiangsu Key Laboratory for Supramolecular Medicinal Materials and Applications, Nanjing 210046, China.
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Han
authors.forename: Hui-Na
authors.initials: HN
authors.lastname: Pei
authors.forename: Hai-Song
authors.initials: HS
authors.lastname: Sun
authors.forename: Quan-Kui
authors.initials: QK
authors.lastname: Ning
authors.forename: Yong
authors.initials: Y
authors.lastname: Ren
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012995:Solubility; D013607:Tablets / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D003505:Cyclodextrins; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D013607:Tablets; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C093196:SBE4-beta-cyclodextrin; C031215:betadex; C525191:dragon's blood