Novel homo-bimetallic complexes of [N(10)] macrocyclic ligand modified with tetrapeptide function: biological activities, spectral and cyclic voltammetric studies.
The bimetallic complexes [M(2)LCl(4)] (M=Cr, Co, Ni, Cu) prepared via metal template cyclization reactions were characterized by physico-chemical and spectroscopic methods. L is a 30-membered [N(10)] macrocycle with tetraamide functions bind metal ions through aza donors forming hexa-coordinate geometry. The perspective view and important structural parameters have been computed from the molecular model (MOPAC) method. The electrochemical studies indicate existence of quasi-reversible redox couples in solution. The metal complexes were screened (in vitro) against a few pathogenic fungi and bacteria to assess their growth inhibiting potential.
Siddiqi
Zafar A
ZA
Coordination Chemistry Research Group, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. zafarsiddiqi@yahoo.co.in
Kumar
Sarvendra
S
Khalid
Mohd
M
Shahid
M
M
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D003500:Cyclization; D004563:Electrochemistry; D008024:Ligands; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry / Q000378:metabolism
D000900:Anti-Bacterial Agents; D008024:Ligands; D008670:Metals; D010455:Peptides