title: Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part II.
abstract: The antiproliferative activities of aqueous and organic extracts prepared from 26 Hungarian species of the tribes Cynereae and Lactuceae (Asteraceae) were tested in vitro against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells by using the MTT assay. Of the tested 200 extracts of different plant parts obtained with n-hexane, chloroform, 50% methanol and water, 16 extracts displayed noteworthy cell growth inhibitory activity (>50% inhibition at a concentration of 10 microg/mL). The IC50 values of these extracts were determined, and their direct cytotoxic effects were measured. High differences between the antiproliferative and cytotoxic activities, demonstrating a real cell proliferation inhibitory activity rather than direct killing effects, were found for some Centaurea, Cirsium, Cichorium, Lactuca, Onopordum and Scorsonera extracts.
authors.affiliation: Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
authors.forename: Boglárka
authors.initials: B
authors.lastname: Csupor-Löffler
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Hajdú
authors.forename: Borbála
authors.initials: B
authors.lastname: Réthy
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.forename: Imre
authors.initials: I
authors.lastname: Máthé
authors.forename: Tamás
authors.initials: T
authors.lastname: Rédei
authors.forename: George
authors.initials: G
authors.lastname: Falkay
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts