title: Clinical application of artificial bone in the maxillofacial region.
abstract: Hard tissue reconstruction is very useful for bony defects of the maxillofacial region. Autogenous bone, allogeneic bone, and artificial bone have been used to reconstruct maxillofacial bone; however, the use of autogenous bone involves high surgical invasiveness because of the need to harvest the bone. The use of allogeneic bone is associated with infections, raises ethical concerns, and is not widely used in Japan. Artificial bone has several advantages, including no need for bone harvesting, excellent biocompatibility, and a relatively easy surgical procedure. Use of artificial bone avoids the much greater invasiveness of harvesting bone, and several types of artificial bone have been developed. Design requirements for artificial bone include surgical manipulability, structural compatibility with the defective area, support properties, and the ability to induce bone regeneration; however, no artificial bone meeting all these requirements has yet been developed. Artificial bone is used in many patients in our medical center, and we have been active in developing the next generation of artificial bone with better properties. In this article, we present a case history and discuss the future development of artificial bone for use in maxillofacial reconstruction.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. saijyoh-ora@h.u-tokyo.ac.jp
authors.forename: Hideto
authors.initials: H
authors.lastname: Saijo
authors.forename: Ung-il
authors.initials: UI
authors.lastname: Chung
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Igawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Mori
authors.forename: Daichi
authors.initials: D
authors.lastname: Chikazu
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Iino
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takato
mesh_terms: D000293:Adolescent; D017076:Computer-Aided Design; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008447:Maxillofacial Prosthesis; D019931:Maxillofacial Prosthesis Implantation; D011474:Prosthesis Design; D012886:Skull / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed