[Structure and molecular mechanisms of infection and replication of HIV].
Studies on molecular structure and mechanisms of replication of a pathogen are important from both scientific and clinical viewpoints. The replication study allows us to identify key molecules to regulate life cycle of the pathogen and to screen rationally anti-pathogen drugs. The structural study helps understand how the key molecules work at atomic levels and to design adequately the drugs. In this article, we review important findings on structural and replication studies of human immunodeficiency virus (HIV). We also summarize the latest methods for the structural study, mainly focusing on computational simulation technology (in silico analysis). Finally, we summarize briefly standard methods to study replication of viruses.
Sato
Hironori
H
Laboratory of Viral Genomics, Center for Pathogen Genomics, National Institute of Infectious Diseases.
Ode
Hirotaka
H
Motomura
Kazushi
K
Yokoyama
Masaru
M
D003198:Computer Simulation; D023281:Genomics; D006678:HIV / Q000737:chemistry / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*; D015658:HIV Infections / Q000821:virology*; D006801:Humans; D015394:Molecular Structure; D014779:Virus Replication