title: Childhood esophagitis: then and now.
abstract: OBJECTIVE
  It is not known whether the prevalence of childhood esophagitis has changed over time. In children, the intraepithelial eosinophil is considered the hallmark of esophageal inflammation. This study compares the prevalence of intraepithelial eosinophils in esophageal biopsies obtained from 1980-1988 and 2001-2002.
  
  
  METHODS
  This study reevaluated all of the esophageal biopsies obtained at a single center during 2 periods: 1980-1988 and 2001-2002. Histological appearances were characterized and eosinophils per high-power field were quantified.
  
  
  RESULTS
  In total, 1058 esophageal biopsies from 510 subjects were reviewed. Between 1980 and 1988, 247 biopsies from 188 subjects were evaluated. Of these, 62 subjects met the criteria for esophageal disease, and 106 had no specific pathological changes. Between 2001 and 2002, 811 biopsies from 322 subjects were evaluated. Of these, 132 subjects met the criteria for esophageal disease, and 182 had no specific pathological changes. A statistically significant increase in the prevalence of esophageal inflammatory disease was observed comparing the recent group with the remote group. Eosinophilic esophagitis is thought to be distinct from other types of esophagitis in pathogenesis, epidemiology, histology, and treatment. Some suggest the prevalence of eosinophilic esophagitis has increased in recent years. We sought evidence for an increase in histological changes consistent with eosinophilic esophagitis. No matter whether histology consistent with eosinophilic esophagitis was defined as 25, 20, 15, or 10 eosinophils per high-power field, no increase in prevalence was found.
  
  
  CONCLUSIONS
  This study demonstrated no evidence for a change in the density of eosinophilic infiltrates in esophageal biopsies during the 22-year study period. The study showed a statistically significant increase in the prevalence of esophageal inflammatory disease across the same period.
authors.affiliation: Women and Children's Hospital of Buffalo, Buffalo, NY, USA.
authors.forename: Joyce J
authors.initials: JJ
authors.lastname: Lee
authors.forename: Robert D
authors.initials: RD
authors.lastname: Baker
authors.forename: Abdur R
authors.initials: AR
authors.lastname: Khan
authors.forename: Susan S
authors.initials: SS
authors.lastname: Baker
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D004802:Eosinophilia / Q000453:epidemiology / Q000473:pathology; D004804:Eosinophils / Q000473:pathology; D004941:Esophagitis / Q000453:epidemiology* / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male