title: Effect of long-term intervention of soy isoflavones on bone mineral density in women: a meta-analysis of randomized controlled trials.
abstract: BACKGROUND
  A number of RCTs have examined the role of soy isoflavones on bone mineral density (BMD) and yielded inconsistent results. This meta-analyses aims to assess the overall effect of soy isoflavones on BMD.
  
  
  METHODS
  We searched for all articles published in English from January 1990 to March, 2008. We included RCTs of soy isoflavone supplementation in women of at least one year duration. The main outcomes were BMD changes from baseline at the lumbar spine, total hip and femoral neck.
  
  
  RESULTS
  We identified 10 eligible RCTs containing 896 women. A mean dose of 87 mg soy isoflavones for at least one year did not significantly affect BMD changes. The mean (95%CI) differences in BMD changes (in mg/cm(2)/year) were 4.1 (-1.6, 9.8) (0.4%) at the lumbar spine, -1.5 (-7.2, 4.3) (-0.3%) at the femoral neck under random-effects model, and 2.5 (-0.5, 5.4) (0.2%) at the total hip by fix-effects model, respectively. Similar results were obtained in subgroup analyses by isoflavone sources (soy protein vs. isoflavone extract), ethnic differences (Asian vs. Western). Larger dose (>or=80 mg/d), but not lower dose (<80 mg/d), of isoflavone intervention tended to have a weak beneficial effect on spine BMD (p=0.08 vs. p=0.94).
  
  
  CONCLUSIONS
  Soy isoflavone supplementation is unlikely to have significant favorable on BMD at the lumbar spine and hip in women.
authors.affiliation: Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Suzanne C
authors.initials: SC
authors.lastname: Ho
authors.forename: Yi-xiang
authors.initials: YX
authors.lastname: Su
authors.forename: Wei-qing
authors.initials: WQ
authors.lastname: Chen
authors.forename: Cai-xia
authors.initials: CX
authors.lastname: Zhang
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D015519:Bone Density / Q000187:drug effects*; D005260:Female; D005272:Femur Neck / Q000187:drug effects / Q000378:metabolism; D006621:Hip Joint / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000494:pharmacology*; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000378:metabolism; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D055815:Young Adult
chemical_list: D007529:Isoflavones