Association between genetic and environmental factors and the risk of Alzheimer's disease.
The only well confirmed genetic risk factor for sporadic Alzheimer's disease (AD) is the possession of apolipoprotein E (APOE) epsilon4 allele. As it contributes to 40-70% of AD cases, a large proportion of genetic variance may be determined by additional loci. Our aim was to estimate how reported genetic factors (APOE, NOS3, MTHFR) interact to increase the risk for AD and combine them with environmental factors (homocysteine, vitamin B12, cholesterol). Genotyping was performed in 154 AD patients and 176 healthy controls. Levels of homocysteine, vitamin B12 and cholesterol were assessed in subgroups of 100 AD patients and 100 controls. We found a difference in APOE epsilon4 and NOS3 G/G distribution between groups (p<0.005). Plasma total homocysteine was increased and vitamin B12 decreased in AD patients (p<0.001). The influence of APOE epsilon4 and NOS3 G alleles on the risk of AD was independent of homocysteine, vitamin B12 levels and MTHFR status.
Styczyńska
Maria
M
Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego St., 02-106 Warsaw, Poland. desperat@cmdik.pan.pl
Strosznajder
Joanna B
JB
Religa
Dorota
D
Chodakowska-Zebrowska
Małgorzata
M
Pfeffer
Anna
A
Gabryelewicz
Tomasz
T
Czapski
Grzegorz A
GA
Kobryś
Małgorzata
M
Karciauskas
Gytis
G
Barcikowska
Maria
M
D000544:Alzheimer Disease / Q000097:blood* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006710:Homocysteine / Q000097:blood; D006801:Humans; D006937:Hypercholesterolemia; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics; D012307:Risk Factors; D014805:Vitamin B 12 / Q000097:blood
D001057:Apolipoproteins E; D006710:Homocysteine; C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D014805:Vitamin B 12