Effect of autologous platelet adhesives on dermal fat graft resorption following reconstruction of a superficial parotidectomy defect: a double-blinded prospective trial.
BACKGROUND
Dermal fat grafts are used to reconstruct facial contour defects but may undergo variable resorption. Application of autologous platelet adhesive may improve outcomes. The primary objective was to compare resorption of dermal fat grafts for parotidectomy defects, between patients receiving autologous platelet adhesive versus controls.


METHODS
This was a double-blinded prospective cohort at a tertiary care center. Volumetric analyses of dermal fat graft measured by MRI scans. Resorption was determined by comparing 1- and 6-month MRIs in each patient. Complications, Frey's Syndrome, and patient satisfaction were also assessed.


RESULTS
Twelve patients completed the study. A significant reduction in graft resorption was seen in the treatment group (57% vs. 31%, p = .01). Three patients in the control group developed fat liquefaction. Patient perceived significant differences in scar and contour.


CONCLUSIONS
Application of autologous platelet adhesives improved graft viability and patient satisfaction at 6 months.
Chandarana
Shamir
S
Department of Otolaryngology, London Health Sciences Centre-Victoria Hospital, 800 Commissioners Road East, London, Ontario, Canada.
Fung
Kevin
K
Franklin
Jason H
JH
Kotylak
Trevor
T
Matic
Damir B
DB
Yoo
John
J
D004311:Double-Blind Method; D005145:Face / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000601:surgery*; D010307:Parotid Neoplasms / Q000601:surgery*; D017060:Patient Satisfaction; D019651:Plastic Surgery Procedures / Q000009:adverse effects / Q000379:methods*; D050151:Subcutaneous Fat / Q000473:pathology / Q000637:transplantation*
D015718:Fibrin Tissue Adhesive