title: Non-sexually related acute genital ulcers in 13 pubertal girls: a clinical and microbiological study.
abstract: OBJECTIVE
  To describe the clinical and microbiological features of acute genital ulcers (AGU), which have been reported in virgin adolescents, predominantly in girls.
  
  
  METHODS
  Descriptive study. We collected data on the clinical features, sexual history, blood cell count, biochemistry, microbiological workup, and 1-year follow-up.
  
  
  METHODS
  Departments of dermatology of 3 university hospitals in Paris. Patients Thirteen immunocompetent female patients with a first flare of non-sexually transmitted AGU.
  
  
  METHODS
  Clinical and microbiological data, using a standardized form.
  
  
  RESULTS
  Mean age was 16.6 years (range, 11-19 years). Eleven patients denied previous sexual contact. A fever or flulike symptoms preceded AGU in 10 of the 13 patients (77%), with a mean delay of 3.8 days before the AGU onset (range, 0-10 days). The genital ulcers were bilateral in 10 patients. The final diagnosis was Epstein-Barr virus primary infection in 4 patients (31%) and Behçet disease in 1 patient (8%). No other infectious agents were detected in this series.
  
  
  CONCLUSIONS
  We recommend serologic testing for Epstein-Barr virus with IgM antibodies to viral capsid antigens in non-sexually related AGU in immunocompetent patients. Further microbiological studies are required to identify other causative agents.
authors.affiliation: Service de Dermatologie, Pavillon Tarnier, CHU Cochin, 89 rue d'Assas, 75006 Paris, France.
authors.forename: David
authors.initials: D
authors.lastname: Farhi
authors.forename: Jeanne
authors.initials: J
authors.lastname: Wendling
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Molinari
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Raynal
authors.forename: Guislaine
authors.initials: G
authors.lastname: Carcelain
authors.forename: Patrice
authors.initials: P
authors.lastname: Morand
authors.forename: Marie-Françoise
authors.initials: MF
authors.lastname: Avril
authors.forename: Camille
authors.initials: C
authors.lastname: Francès
authors.forename: Flore
authors.initials: F
authors.lastname: Rozenberg
authors.forename: Monique
authors.initials: M
authors.lastname: Pelisse
authors.forename: Nicolas
authors.initials: N
authors.lastname: Dupin
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000473:pathology / Q000635:transmission; D005260:Female; D006801:Humans; D014456:Ulcer / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D014845:Vulvar Diseases / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology