title: Genetic thrombophilia variants and risk for preeclampsia among American Indians.
abstract: OBJECTIVE
  To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.
  
  
  METHODS
  A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.
  
  
  RESULTS
  The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.
  
  
  CONCLUSIONS
  The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.
authors.affiliation: Turtle Mountain Community College, Belcourt, North Dakota, USA. sbest@utma.com
authors.forename: Lyle G
authors.initials: LG
authors.lastname: Best
authors.forename: Sheri T
authors.initials: ST
authors.lastname: Dorsam
authors.forename: Melanie
authors.initials: M
authors.lastname: Nadeau
authors.forename: Larry
authors.initials: L
authors.lastname: Burd
authors.forename: Cindy M
authors.initials: CM
authors.lastname: Anderson
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000235:genetics*; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin