title: Cortical complexity analysis of patients with bipolar disorder using three-dimensional gyrification index.
abstract: Bipolar disorder (BD) is a common affective disorder. In morphometric brain imaging studies, BD subjects have atrophic gray matter, especially in the prefrontal area. These structural abnormalities could involve the change of cortical shape. Gyrification index (GI) is a useful metric to measure the degree of cortical complexity. This work aims to compare the cortical development between bipolar patients and healthy controls using GI. No significant difference was detected between two groups. However, we found asymmetry pattern of cortical complexity was increased in limbic lobe on bipolar patients. Significant negative correlation was also observed between rating scores and asymmetry coefficients in frontal lobe.
authors.affiliation: Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan. yuanlin@vision.csie.ncku.edu.tw
authors.forename: Yuan-Lin
authors.initials: YL
authors.lastname: Liao
authors.forename: Yung-Nien
authors.initials: YN
authors.lastname: Sun
authors.forename: Jen-Chuen
authors.initials: JC
authors.lastname: Hsieh
authors.forename: Tung-Ping
authors.initials: TP
authors.lastname: Su
authors.forename: Wan-Yuo
authors.initials: WY
authors.lastname: Guo
authors.forename: Yu-Te
authors.initials: YT
authors.lastname: Wu
mesh_terms: D000328:Adult; D000465:Algorithms; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003198:Computer Simulation; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical