[In vitro experimental study on the effect of resveratrol against several kinds of respiroviruses].
OBJECTIVE
To observe the cytopathogenic inhibitory effect of resveratrol on vary respiroviruses and explore the mechanism of resveratrol against viruses.


METHODS
MDCK, A549, HEp-2 cell and MRC-5 were infected with Influenza virus type A FM1 strain, rhinovirus type R14, RS virus, AD virus type 7 separately, and the antiviral activity of resveratrol were observed.


RESULTS
Resveratrol significantly inhibited cytopathogenic effect of AD virus type 7 at the concentration 120 microg/ml. No significant cytopathogenic effect of Resveratrol inhibiting Influenza virus type A FM1 strain, Rhinovirus type R14, RS virus on separate cells was observed.


CONCLUSIONS
It is concluded that resveratrol is effective on inhibiting AD virus type 7 in vitro, however, its mechanism is needed for further study.
Guan
Wen-Da
WD
Molecular Immunology and Antibody Engineering Center, Jinan University, Guangzhou 510632, China.
Yang
Zi-Feng
ZF
Liu
Ni
N
Qin
Sheng
S
Zhang
Feng-Xue
FX
Zhu
Yu-Tong
YT
D000260:Adenoviruses, Human / Q000187:drug effects*; D000998:Antiviral Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003588:Cytopathogenic Effect, Viral; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D012328:RNA Viruses / Q000187:drug effects*; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D012229:Rhinovirus / Q000187:drug effects; D014704:Veratrum Alkaloids / Q000494:pharmacology*
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal; D014704:Veratrum Alkaloids