title: [Effects of Yuquan pills on pharmacokinetics of metformin hydrochloride in diabetic rats].
abstract: OBJECTIVE
  To study effects of Yuquan pills on the pharmacokinetics process of metformin hydrochloride in diabetic rats.
  
  
  METHODS
  After administration Yuquan pills 7 day to the diabetic rats, the metformin hydrochloride was orally administrated, then the blood samples were collected at different time. The concentrations of metformin hydrochloride in plasma were determined by HPLC method and the pharmacokinetic parameters were calculated.
  
  
  RESULTS
  The pharmacokinetic parameter Cmax of the controlling group and the testing group were respectively, 18.95, 21.76 mg x L(-1); t1/2 were 1,069.8, 1,767.4 min, respectively; CL/F were 0.013, 0.008 L x min(-1) x kg(-1); AUC were 10,042.1, 10,712.2 mg z L(-1) x min(-1) respectively.
  
  
  CONCLUSIONS
  The pharmacokinetics process of metformin hydrochloride in diabetic rats fits one-compartment model. Yuquan pills has a significant effect on the pharmacokinetics of metformin hydrochloride in diabetic rats.
authors.affiliation: Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou 730000, China. duanhg06@163.com
authors.forename: Hao-Gang
authors.initials: HG
authors.lastname: Duan
authors.forename: Yu-Hui
authors.initials: YH
authors.lastname: Wei
authors.forename: Bo-Xia
authors.initials: BX
authors.lastname: Li
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Jin-Wen
authors.initials: JW
authors.lastname: Zhang
authors.forename: Xin-An
authors.initials: XA
authors.lastname: Wu
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004347:Drug Interactions; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D008687:Metformin / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal; D008687:Metformin