[Selective disruption of memory consolidation in chicks produced by 5'-iodo-2'-deoxyuridine].
We tested the hypothesis that DNA synthesis is involved in molecular mechanisms of memory consolidation. Nucleotide analogs 5'-iodo- and 5'-bromo-2'-deoxyuridine impair DNA functions being incorporated into elongated DNA chain and cause amnesia in a number of training models in mice. We studied possible amnestic effects of 5'-iodo-2'-deoxyuridine (IdU) in different training models in newborn chicks--in passive avoidance, taste aversion, imprinting and spatial learning in a maze. In the taste aversion model injection of IdU (10 mg/kg 5 min before or 50 min after training) produced amnesia at test 1-2 days after training, at the same time it had no effect on memory retention in test 6 h after training. IdU injection 2 h after training produced no amnesia. Similar amnestic effect in taste aversion model was found for 5'-bromo-2'-deoxyuridine (BrdU). In models of imprinting, passive avoidance and spatial learning IdU injection before or after training had no effect on memory retention. These data presuppose that brain DNA synthesis might play a critical role in mechanisms of memory consolidation in taste aversion learning in chicks.
Komissarova
N V
NV
Tiunova
A A
AA
Anokhin
K V
KV
D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002645:Chickens; D004247:DNA / Q000096:biosynthesis; D007065:Idoxuridine / Q000494:pharmacology*; D007173:Imprinting, Psychological / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D055697:Taste Perception / Q000187:drug effects / Q000502:physiology
D011500:Protein Synthesis Inhibitors; D004247:DNA; D001973:Bromodeoxyuridine; D007065:Idoxuridine