title: Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder.
abstract: It has been suggested that alteration in the muscarinic-cholinergic system is involved in modulation of mood. Three studies have reported linkage on chromosome 7 with major depressive disorder (MDD) in or close to a region containing the muscarinic receptor CHRM2 gene. A haplotype of SNPs located in CHRM2 (rs1824024-rs2061174-rs324650) has been significantly associated with MDD in a previous study. We report the first study investigating this gene in a large, adequately powered, clinical depression case-control sample (n = 1420 cases, 1624 controls). Our data fail to support association with the CHRM2 polymorphisms previously implicated in the genetic aetiology of depression. It is possible our failure to replicate may be a consequence of differences in definition of the MDD phenotype and/or ethnic differences.
authors.affiliation: MRC SGDP Centre, Institute of Psychiatry, King's College London, London, UK. sarah.cohen@iop.kcl.ac.uk
authors.forename: Sarah
authors.initials: S
authors.lastname: Cohen-Woods
authors.forename: Daria
authors.initials: D
authors.lastname: Gaysina
authors.forename: Nick
authors.initials: N
authors.lastname: Craddock
authors.forename: Anne
authors.initials: A
authors.lastname: Farmer
authors.forename: Joanna
authors.initials: J
authors.lastname: Gray
authors.forename: Cerisse
authors.initials: C
authors.lastname: Gunasinghe
authors.forename: Farzana
authors.initials: F
authors.lastname: Hoda
authors.forename: Lisa
authors.initials: L
authors.lastname: Jones
authors.forename: Jo
authors.initials: J
authors.lastname: Knight
authors.forename: Ania
authors.initials: A
authors.lastname: Korszun
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Owen
authors.forename: Abram
authors.initials: A
authors.lastname: Sterne
authors.forename: Ian W
authors.initials: IW
authors.lastname: Craig
authors.forename: Peter
authors.initials: P
authors.lastname: McGuffin
mesh_terms: D016022:Case-Control Studies; D003866:Depressive Disorder / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006239:Haplotypes; D006801:Humans; D008297:Male; D008875:Middle Aged; D043585:Receptor, Muscarinic M2 / Q000235:genetics*; D012008:Recurrence
chemical_list: C487078:CHRM2 protein, human; D043585:Receptor, Muscarinic M2