[Correlations between clinical and immunological parameters in endogenous psychoses with a first episode at the juvenile age].
Sixty-seven patients, aged 16-25 years, with the first episode of endogenous psychosis (ICD-10 items F20.03, F20.23, F25) have been examined. Positive, negative and general psychopathological symptoms were assessed with the PANSS. Activities of leukocyte elastase (LE) and alpha1-proteinase inhibitor were used for measuring of innate immunity and the level of autoantibodies to nerve growth factor (Aab-NGF) was used for measuring of adaptive immunity. The manifestation of endogenous psychosis was accompanied by the activation of innate immunity, the level of activation was not related with the syndrome structure of episode (the prevalence of catatonic, hallucinatory-delusional or affective-delusional symptoms). The LE activity and dynamics of Aab-NGF during the treatment may be considered as prognostic markers of treatment effectiveness: the higher LE activity during the episode and decrease of Aab-NGF in the treatment process may predict a favorable therapeutic response.
Kaleda
V G
VG
Kliushnik
T P
TP
Sarmanova
Z V
ZV
Otman
I N
IN
Dupin
A M
AM
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D014150:Antipsychotic Agents / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D019272:Leukocyte Elastase / Q000378:metabolism; D008297:Male; D020932:Nerve Growth Factor / Q000276:immunology* / Q000378:metabolism; D011379:Prognosis; D011618:Psychotic Disorders / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D014150:Antipsychotic Agents; D000515:alpha 1-Antitrypsin; D020932:Nerve Growth Factor; D019272:Leukocyte Elastase