title: Cardiac motion recovery via active trajectory field models.
abstract: Cardiovascular researchers are constantly developing new and innovative medical imaging technologies, striving to improve the understanding, diagnosis, and treatment of cardiovascular dysfunction. Combining these sophisticated imaging methods with advancements in image understanding via computational intelligence will continue to advance the frontier of cardiovascular medicine. Recently, researchers have turned to a new class of tissue motion imaging techniques, including displacement encoding with stimulated echoes (DENSE) in cardiac magnetic resonance (cMR) imaging, to directly quantify cardiac displacement and produce accurate spatiotemporal measurements of myocardial strain, twist, and torsion. The associated analysis of DENSE cMR and other tissue motion imagery, however, represents a major bottleneck in the study of intramyocardial mechanics. In the computational intelligence area of deformable models, this paper develops an automated motion recovery technique termed active trajectory field models (ATFMs) geared toward these new motion imaging protocols, offering quantitative physiological measurements without the pains of manual analyses. This novel generative deformable model exploits both image information and prior knowledge of cardiac motion, utilizing a point distribution model derived from a training set of myocardial trajectory fields to automatically recover cardiac motion from a noisy image sequence. The effectiveness of the ATFM method is demonstrated by quantifying myocardial motion in 2-D short-axis murine DENSE cMR image sequences both before and after myocardial infarction, producing results comparable to existing semiautomatic analysis methods.
authors.affiliation: C. L. Brown Department of Electrical and ComputerEngineering, University of Virginia, Charlottesville, VA 22904, USA. drew.gilliam@virginia.edu
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Gilliam
authors.forename: Frederick H
authors.initials: FH
authors.lastname: Epstein
authors.forename: Scott T
authors.initials: ST
authors.lastname: Acton
mesh_terms: D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D051379:Mice; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000503:physiopathology; D025341:Principal Component Analysis