title: Mechanically assisted 3D ultrasound guided prostate biopsy system.
abstract: There are currently limitations associated with the prostate biopsy procedure, which is the most commonly used method for a definitive diagnosis of prostate cancer. With the use of two-dimensional (2D) transrectal ultrasound (TRUS) for needle-guidance in this procedure, the physician has restricted anatomical reference points for guiding the needle to target sites. Further, any motion of the physician's hand during the procedure may cause the prostate to move or deform to a prohibitive extent. These variations make it difficult to establish a consistent reference frame for guiding a needle. We have developed a 3D navigation system for prostate biopsy, which addresses these shortcomings. This system is composed of a 3D US imaging subsystem and a passive mechanical arm to minimize prostate motion. To validate our prototype, a series of experiments were performed on prostate phantoms. The 3D scan of the string phantom produced minimal geometric distortions, and the geometric error of the 3D imaging subsystem was 0.37 mm. The accuracy of 3D prostate segmentation was determined by comparing the known volume in a certified phantom to a reconstructed volume generated by our system and was shown to estimate the volume with less then 5% error. Biopsy needle guidance accuracy tests in agar prostate phantoms showed that the mean error was 2.1 mm and the 3D location of the biopsy core was recorded with a mean error of 1.8 mm. In this paper, we describe the mechanical design and validation of the prototype system using an in vitro prostate phantom. Preliminary results from an ongoing clinical trial show that prostate motion is small with an in-plane displacement of less than 1 mm during the biopsy procedure.
authors.affiliation: Robarts Research Institute, London, Ontario, Canada. jbax@imaging.robarts.ca
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Bax
authors.forename: Derek
authors.initials: D
authors.lastname: Cool
authors.forename: Lori
authors.initials: L
authors.lastname: Gardi
authors.forename: Kerry
authors.initials: K
authors.lastname: Knight
authors.forename: David
authors.initials: D
authors.lastname: Smith
authors.forename: Jacques
authors.initials: J
authors.lastname: Montreuil
authors.forename: Shi
authors.initials: S
authors.lastname: Sherebrin
authors.forename: Cesare
authors.initials: C
authors.lastname: Romagnoli
authors.forename: Aaron
authors.initials: A
authors.lastname: Fenster
mesh_terms: D000362:Agar / Q000737:chemistry; D001696:Biomechanical Phenomena; D001707:Biopsy, Needle / Q000379:methods; D004867:Equipment Design; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D066298:In Vitro Techniques; D008297:Male; D009339:Needles; D019047:Phantoms, Imaging; D011467:Prostate / Q000000981:diagnostic imaging* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D015203:Reproducibility of Results; D013314:Stress, Mechanical; D014463:Ultrasonography / Q000379:methods; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000473:pathology
chemical_list: D000362:Agar