title: Genetic variation in the lymphotoxin-alpha pathway and the risk of ischemic stroke in European populations.
abstract: OBJECTIVE
  Several genes involved in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) have been linked with the risk of myocardial infarction. Here, we present a comprehensive analysis of these genes in patients with ischemic stroke (IS).
  
  
  METHODS
  Twenty-three single nucleotide polymorphisms (SNPs) from LTA, LGALS2, and PSMA6 were genotyped in 601 German IS patients and 736 matched controls. SNPs and haplotypes were tested for association with overall IS, large vessel stroke, and cardioembolic stroke. Significant associations were replicated in an independent sample of 843 IS cases and 933 controls from the UK.
  
  
  RESULTS
  Only one SNP (rs1048990 in PSMA6) showed association with overall IS, but this was not replicated in the UK sample. Three SNPs showed significant associations with stroke subtypes (P<0.05), but none of these associations could be replicated in the UK population.
  
  
  CONCLUSIONS
  Genetic variation in the lymphotoxin-alpha cascade (LTA, LGALS2, and PSMA6) is not a major risk factor for IS.
authors.forename: Tobias
authors.initials: T
authors.lastname: Freilinger
authors.forename: Steve
authors.initials: S
authors.lastname: Bevan
authors.forename: Stephan
authors.initials: S
authors.lastname: Ripke
authors.forename: Andreas
authors.initials: A
authors.lastname: Gschwendtner
authors.forename: Peter
authors.initials: P
authors.lastname: Lichtner
authors.forename: Bertram
authors.initials: B
authors.lastname: Müller-Myhsok
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Hugh S
authors.initials: HS
authors.lastname: Markus
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D037501:Galectin 2 / Q000235:genetics / Q000502:physiology; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008233:Lymphotoxin-alpha / Q000235:genetics* / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D020521:Stroke / Q000145:classification / Q000453:epidemiology* / Q000235:genetics*; D006113:United Kingdom / Q000453:epidemiology
chemical_list: D037501:Galectin 2; D008233:Lymphotoxin-alpha; C465641:PSMA6 protein, human; D046988:Proteasome Endopeptidase Complex