[Molecular aspects of lymph node metastasis].
The risk of local and systemic lymphatic metastasis of a tumor increases with the size of the malignant neoplasia. Lymph vessels are generated in the tumor and seem to follow anatomically defined pathways. However, the precise molecular and biological mechanisms seem to be complex and require definition. At present, molecules belonging to the vascular endothelial growth factors family and podoplanin have been identified as key for the proliferation of the tumor's lacteals. Molecular mechanisms of the tumor origin and the hematogenic and lymphatic dissemination are increasingly better defined by the use of new diagnostic and therapeutic approaches for tumor patients. Simultaneously, we might be able to influence processes such as cell growth, apoptosis, angiogenesis, and lymphogenic dissemination by novel drugs and thereby develop novel approaches for tumor treatment. Chemokine receptors seem to control essential steps of lymphogenic dissemination such as migration, invasion, and proliferation of tumor cells.
Schenck
M
M
Urologische Klinik, Universitätsklinikum Essen, Universität Duisburg-Essen, Hufelandstrasse 55, 45122 Essen. marcus.schenck@uk-essen.de
Rübben
H
H
Gulbins
E
E
D016207:Cytokines / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology*; D008207:Lymphatic Metastasis / Q000276:immunology*; D018448:Models, Immunological; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology*
D016207:Cytokines; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A