Prevention of non-communicable disease in a population in nutrition transition: Tehran Lipid and Glucose Study phase II.
BACKGROUND
The Tehran Lipid and Glucose Study (TLGS) is a long term integrated community-based program for prevention of non-communicable disorders (NCD) by development of a healthy lifestyle and reduction of NCD risk factors. The study begun in 1999, is ongoing, to be continued for at least 20 years. A primary survey was done to collect baseline data in 15005 individuals, over 3 years of age, selected from cohorts of three medical heath centers. A questionnaire for past medical history and data was completed during interviews; blood pressure, pulse rate, and anthropometrical measurements and a limited physical examination were performed and lipid profiles, fasting blood sugar and 2-hours-postload-glucose challenge were measured. A DNA bank was also collected. For those subjects aged over 30 years, Rose questionnaire was completed and an electrocardiogram was taken. Data collected were directly stored in computers as database software- computer assisted system. The aim of this study is to evaluate the feasibility and effectiveness of lifestyle modification in preventing or postponing the development of NCD risk factors and outcomes in the TLGS population.


METHODS
In phase II of the TLGS, lifestyle interventions were implemented in 5630 people and 9375 individuals served as controls. Primary, secondary and tertiary interventions were designed based on specific target groups including schoolchildren, housewives, and high-risk persons. Officials of various sectors such as health, education, municipality, police, media, traders and community leaders were actively engaged as decision makers and collaborators. Interventional strategies were based on lifestyle modifications in diet, smoking and physical activity through face-to-face education, leaflets & brochures, school program alterations, training volunteers as health team and treating patients with NCD risk factors. Collection of demographic, clinical and laboratory data will be repeated every 3 years to assess the effects of different interventions in the intervention group as compared to control group.


CONCLUSIONS
This controlled community intervention will test the possibility of preventing or delaying the onset of non-communicable risk factors and disorders in a population in nutrition transition.


BACKGROUND
ISRCTN52588395.
Azizi
Fereidoun
F
Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University (M. C), Tehran, Iran. azizi@endocrine.ac.ir
Ghanbarian
Arash
A
Momenan
Amir Abbas
AA
Hadaegh
Farzad
F
Mirmiran
Parvin
P
Hedayati
Mehdi
M
Mehrabi
Yadollah
Y
Zahedi-Asl
Saleh
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004562:Electrocardiography; D015444:Exercise; D005240:Feasibility Studies; D005247:Feeding Behavior; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006293:Health Promotion; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008055:Lipids / Q000097:blood*; D008297:Male; D008487:Medical History Taking; D008659:Metabolic Diseases / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D008875:Middle Aged; D009752:Nutritional Status; D010353:Patient Education as Topic; D011322:Primary Prevention; D016730:Program Development; D011446:Prospective Studies; D040242:Risk Reduction Behavior; D016540:Smoking Cessation; D011795:Surveys and Questionnaires; D013997:Time Factors; D055815:Young Adult
D015415:Biomarkers; D001786:Blood Glucose; D008055:Lipids