title: Quantitation of proteinuria in nephrotic syndrome by spot urine protein creatinine ratio estimation in children.
abstract: In Nephrotic Syndrome the amount of protein excretion is a reflection of activity of disease. Quantitative measurement of proteinuria by a 24-hour urine collection has been the accepted method of evaluation. Recent studies have shown that calculation of protein/creatinine ratio in a spot urine sample correlates well with the 24-hour urine protein (24-HUP) excretion. A study was conducted to compare the accuracy of a spot urinary protein/creatinine ratio (P/C ratio) and urinary dipstick with the 24-hour urine protein. Fifty two samples from 26 patients of nephrotic syndrome were collected. This included a 24-hour urine sample followed by the next voided random spot sample. The protein/creatinine ratio was calculated and dipstick was performed on the spot sample. This was compared with the 24-hour urine protein excretion. The correlation between the three samples was statistically highly significant (p<0.001) for all levels of proteinuria. The normal value of protein/creatinine ratio in Indian children was also estimated on 50 normal children admitted in the ward without any renal diseases calculated to be 0.053 (SE of mean+/-0.003).
authors.affiliation: Doctors Chummary Hostel, 41 Eden Hospital Road, Kolkata-70073, West Bengal, India. dr24arnab@rediffmail.com
authors.forename: A
authors.initials: A
authors.lastname: Biswas
authors.forename: R
authors.initials: R
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Chaterjee
authors.forename: J K
authors.initials: JK
authors.lastname: Ghosh
authors.forename: K
authors.initials: K
authors.lastname: Basu
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D007677:Kidney Function Tests; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine*; D011446:Prospective Studies; D011507:Proteinuria / Q000175:diagnosis / Q000503:physiopathology / Q000652:urine*; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D003404:Creatinine