title: Cassane diterpenes from Caesalpinia bonduc.
abstract: Three cassane diterpene hemiketals, caesalpinolide-C, caesalpinolide-D, caesalpinolide-E and one cassane furanoditerpene were isolated from Caesalpinia bonduc. The molecular structures were elucidated using NMR spectroscopy in combination with IR, UV and mass spectral data and relative stereochemistries were determined through ROESY correlation. The isolated compounds were tested for their antiproliferative activity against MCF-7 (breast adenocarcinoma), DU145 (prostate carcinoma), C33A (Cervical carcinoma) and Vero (African green monkey kidney fibroblast) cells.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India. pp_yadav@cdri.res.in
authors.forename: Prem P
authors.initials: PP
authors.lastname: Yadav
authors.forename: Ranjani
authors.initials: R
authors.lastname: Maurya
authors.forename: Jayanta
authors.initials: J
authors.lastname: Sarkar
authors.forename: Ashish
authors.initials: A
authors.lastname: Arora
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Kanojiya
authors.forename: Sudhir
authors.initials: S
authors.lastname: Sinha
authors.forename: M N
authors.initials: MN
authors.lastname: Srivastava
authors.forename: Ram
authors.initials: R
authors.lastname: Raghubir
mesh_terms: D000818:Animals; D029911:Caesalpinia / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D004224:Diterpenes