title: Disseminated Geosmithia argillacea infection in a German shepherd dog.
abstract: We report a systemic mycosis in a German Shepherd dog caused by Geosmithia argillacea. Although this etiologic agent microscopically resembles a Penicillium species, and is histopathologically compatible with members of the genus Aspergillus, morphologic features and molecular characterization clearly separate it from these genera. This appears to be the first report of disseminated disease by this species in humans or animals. In vitro antifungal susceptibility testing suggests resistance to amphotericin B and voriconazole and susceptibility to caspofungin, itraconazole, and posaconazole.
authors.affiliation: Department of Small Animal Clinical Sciences, Virginia Tech, Blacksburg. VA, USA. dgrant@vt.edu
authors.forename: David C
authors.initials: DC
authors.lastname: Grant
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Christina A
authors.initials: CA
authors.lastname: Sandberg
authors.forename: Ronald D
authors.initials: RD
authors.lastname: Tyler
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Thompson
authors.forename: Anna M
authors.initials: AM
authors.lastname: Romanelli
authors.forename: Brian L
authors.initials: BL
authors.lastname: Wickes
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000382:microbiology / Q000473:pathology; D004285:Dogs; D005260:Female; D007668:Kidney / Q000473:pathology; D009181:Mycoses / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D013166:Spondylitis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D032901:Talaromyces / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D013904:Thoracic Vertebrae / Q000382:microbiology / Q000473:pathology; D014556:Urine / Q000382:microbiology