Efficacy of ciprofloxacin in an experimental model of Escherichia coli chorioamnionitis in rabbits.
Pregnant rabbits were treated with ciprofloxacin alone or with gentamicin in a model of Escherichia coli chorioamnionitis, and the results were compared with those for untreated rabbits. The survival rate increased and the bacteremia decreased significantly in treated fetuses in comparison to controls (P = 0.003). Nevertheless, rapid selection of resistant mutants is a major limit to ciprofloxacin applications.
Launay
Elise
E
Département de Périnatologie, Hôpital Mère Enfant CHU Nantes, Nantes CEDEX 1, France.
Joram
Nicolas
N
Jacqueline
Cédric
C
Miegeville
Anne Francoise
AF
Caillon
Jocelyne
J
Potel
Gilles
G
Roze
Jean Christophe
JC
Gras-Le Guen
Christèle
C
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002821:Chorioamnionitis / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D005333:Fetus / Q000378:metabolism; D011247:Pregnancy; D011817:Rabbits
D000890:Anti-Infective Agents; D002939:Ciprofloxacin