title: C. elegans fat storage and metabolic regulation.
abstract: C. elegans has long been used as an experimentally tractable organism for discovery of fundamental mechanisms that underlie metazoan cellular function, development, neurobiology, and behavior. C. elegans has more recently been exploited to study the interplay of environment and genetics on lipid storage pathways. As an experimental platform, C. elegans is amenable to an extensive array of forward and reverse genetic, a variety of "omics" and anatomical approaches that together allow dissection of complex physiological pathways. This is particularly relevant to the study of fat biology, as energy balance is ultimately an organismal process that involves behavior, nutrient digestion, uptake and transport, as well as a variety of cellular activities that determine the balance between lipid storage and utilization. C. elegans offers the opportunity to dissect these pathways and various cellular and organismal homeostatic mechanisms in the context of a genetically tractable, intact organism.
authors.affiliation: Department of Physiology and UCSF Diabetes Center, 600 16th Street, Mission Bay Campus 2240, University of California, San Francisco, CA 94158-2517, USA.
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Mullaney
authors.forename: Kaveh
authors.initials: K
authors.lastname: Ashrafi
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000201:enzymology / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006706:Homeostasis; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D005227:Fatty Acids; D008074:Lipoproteins