title: Copper(I)-catalyzed synthesis of substituted 2-mercapto benzimidazoles.
abstract: An efficient method for the preparation of various substituted 2-mercapto benzimidazoles from their corresponding thioureas has been developed. S-alkylation of thioureas followed by Cu-catalyzed intramolecular N-arylation furnished substituted 2-mercapto benzimidazoles in high yields and short reaction times. Furthermore, 2-mercapto benzimidazoles substituted with a p-methoxybenzyl group allowed access to benzimidazole thiones.
authors.affiliation: Institut de Chimie Moléculaire de Reims, UMR 6229 CNRS-Université de Reims Champagne-Ardenne, UFR des Sciences exactes et naturelles, BP 1039, 51687 REIMS Cedex 2, France.
authors.forename: Siva
authors.initials: S
authors.lastname: Murru
authors.forename: Bhisma K
authors.initials: BK
authors.lastname: Patel
authors.forename: Jean
authors.initials: J
authors.lastname: Le Bras
authors.forename: Jacques
authors.initials: J
authors.lastname: Muzart
mesh_terms: D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001562:Benzimidazoles; D003300:Copper