Homocysteine level and metabolism in ischemic stroke in the population of Northern Poland.
OBJECTIVE
In this study we analyzed the occurrence of ischemic brain stroke in Northern Poland in regard to risk factors.


METHODS
131 ischemic stroke patients and 64 controls were studied. Analyzed risk factors included conventional risk factors, total plasma homocysteine level and polymorphisms of the main enzymes of homocysteine metabolism-methylenetetrahydrofolate reductase (polymorphisms C677T and A1298C) and cystathionine beta synthase (polymorphism T833C).


RESULTS
We confirmed the occurrence of a number of conventional risk factors in ischemic stroke. We found that hyperhomocysteinemia is an independent risk factor (p=0.0001). Plasma homocysteine correlated inversely with plasma vitamin B(6). We also found a relationship between C677T polymorphism type and hyperhomocysteinemia (p=0.0266).


CONCLUSIONS
The occurrence of studied polymorphisms in the population of northern Poland was higher than reported previously for similar populations. However, none of the studied genetic factors were found to be significant risk factors in ischemic brain stroke.
Sawuła
Wojciech
W
Department of Molecular and Cellular Biology, Intercollegiate Faculty of Biotechnology University of Gdańsk and Medical University of Gdańsk, Poland.
Banecka-Majkutewicz
Zyta
Z
Kadziński
Leszek
L
Jakóbkiewicz-Banecka
Joanna
J
Wegrzyn
Grzegorz
G
Nyka
Walenty
W
Banecki
Bogdan
B
D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2) / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000097:blood* / Q000209:etiology; D003541:Cystathionine beta-Synthase / Q000235:genetics; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000097:blood / Q000150:complications / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D011732:Pyridoxal Phosphate / Q000097:blood; D012189:Retrospective Studies; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D025101:Vitamin B 6 / Q000097:blood
D006710:Homocysteine; D011732:Pyridoxal Phosphate; D025101:Vitamin B 6; D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D003541:Cystathionine beta-Synthase