Prolonged platelet activation in individuals with elevated blood pressure in response to a moderate exercise challenge.
We examined the magnitude of 20-min moderate exercise-induced platelet activation in 50 volunteers with normal (n=31) or elevated blood pressure (EBP; n=19). Blood was drawn before, immediately after, and 25 min after exercise. Antibody-staining for platelet activation markers, P-selectin, and fibrinogen receptors was done with and without adenosine diphosphate (ADP) stimulation in whole blood for flow cytometric analyses. Exercise led to increases in percent aggregated platelets and percent platelets expressing P-selectin or PAC-1 binding (ps< or =.001). This increase in percent platelets expressing P-selectin continued even after a 25-min rest only in the EBP group (p< or =.01) accompanied by an increase in percent of aggregated platelets (p< or =.05). Although ADP stimulation led to increased platelet activation at rest, it was attenuated following exercise, even among EBP individuals. A moderate exercise challenge induced prolonged platelet activation in individuals with EBP but attenuation in activation to further stimulation by an agonist. Findings suggest that a recovery period after physical stress appears critical in individuals with high BP regarding platelet activation and aggregation, which can lead to an acute coronary syndrome in vulnerable individuals.
Hong
Suzi
S
Department of Psychiatry, La Jolla, California 92093-0804, USA. s1hong@ucsd.edu
Adler
Karen A
KA
Von Känel
Roland
R
Nordberg
Judy
J
Ziegler
Michael G
MG
Mills
Paul J
PJ
D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002395:Catecholamines / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism; D015539:Platelet Activation / Q000502:physiology*; D010976:Platelet Count; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / Q000378:metabolism; D055815:Young Adult
D002395:Catecholamines; D019007:P-Selectin; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I