[Diagnostic value of antineutrophil cytoplasmic antibodies in patients with ulcerative colitis: a meta-analysis].
OBJECTIVE
To evaluate the diagnostic value of antineutrophil cytoplasmic antibodies (ANCA) in patients with ulcerative colitis (UC).


METHODS
Articles related to diagnosis of UC by ANCA test, published before November 2007, were retrieved in the databanks such as Chinese BioMedical Disc, Chinese Medical Current Contents, China National Knowledge Infrastructure, and VIP databank. Related journals were searched manually. Meta-analysis was performed by summary receiver operating characteristic curve recommended by Diagnostic and Screening Group of the Cochrane Collaboration Web with the parameters such as sensitivity, specificity, accuracy, predictive values and likelihood ratio.


RESULTS
Totally 10 studies including 381 patients met the inclusion criteria. Meta-analysis showed that the sensitivity and specificity of ANCA to the diagnosis of UC were 52.2% and 99.0% respectively. The positive and negative predictive values (PPV and NPV) were 98.0% and 68.7% respectively. Meanwhile, the positive and negative likelihood ratio (+LR and -LR) were 52.2 and 0.5, respectively.


CONCLUSIONS
ANCA is an immunological index related to UC. Positive ANCA helps diagnose UC, but is not sensible enough to screen UC.
Cui
Mei-Hua
MH
Department of Gastroenterology, Aerospace Center Hospital, Peking University, Beijing 100049, China.
Liu
Yu-Lan
YL
Yu
Wei-Dong
WD
Li
Xiao-Yu
XY
D000293:Adolescent; D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000166:cytology; D019897:Periplasm / Q000276:immunology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity
D019268:Antibodies, Antineutrophil Cytoplasmic