title: Effect of proton pump inhibition on the gastric volume: assessed by magnetic resonance imaging.
abstract: BACKGROUND
  Proton pump inhibitor (PPI) therapy is known to suppress gastric acid secretion. Thus PPI therapy may decrease gastric volume and gastric contents available for gastro-oesophageal reflux by decreasing acid secretion.
  
  
  OBJECTIVE
  To determine the effect of PPI therapy on the gastric volume after a standard meal.
  
  
  METHODS
  A total of nine healthy subjects were studied using magnetic resonance imaging, before and after a standard liquid meal mixed with a paramagnetic contrast to help demarcate the gastric region. Images were acquired for a total of 90 min after the meal. Studies were conducted before and following esomeprazole twice daily for 7 days. Images were analysed to determine the gastric liquid volume.
  
  
  RESULTS
  Gastric volume, 15 min after the meal peaked to 611 +/- 37 mL on the control day and 539 +/- 30 mL following the PPI administration (P < 0.001). Average gastric volume remained significantly lower (56 +/- 9 mL, P < 0.05) on the PPI therapy from 5 to 75 min after the meal.
  
  
  CONCLUSIONS
  Proton pump inhibitor therapy causes a significant reduction in the gastric contents volume during first 75 min after the meal. In addition to increasing the gastric pH, PPI therapy may decrease the frequency of gastro-oesophageal reflux by decreasing the volume of gastric contents.
authors.affiliation: Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.
authors.forename: A
authors.initials: A
authors.lastname: Babaei
authors.forename: V
authors.initials: V
authors.lastname: Bhargava
authors.forename: S
authors.initials: S
authors.lastname: Aalam
authors.forename: M
authors.initials: M
authors.lastname: Scadeng
authors.forename: R K
authors.initials: RK
authors.lastname: Mittal
mesh_terms: D000328:Adult; D064098:Esomeprazole / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D015588:Observer Variation; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D013270:Stomach / Q000187:drug effects*
chemical_list: D054328:Proton Pump Inhibitors; D064098:Esomeprazole