title: Effects of restricted feeding on blood parameters in pregnant rabbits.
abstract: The effects of restricted feeding (20 g/day from gestational day (GD) 6 to 28) on pregnancy outcome and blood parameters were examined in pregnant rabbits. As compared with the group which was allowed free access to diet throughout the gestational period (NT group), the group subjected to restricted feeding (R group) showed significantly lower values in many parameters such as total protein, albumin and triglyceride on GDs 22 and 28, reflecting low nutritive conditions. In addition, there were significant changes in blood coagulation-related parameters, suggesting an imbalance between coagulation and anti-coagulation factors. Moreover, abortions occurred in about half of the animals of the R group between GDs 23 and 27. When aborted rabbits were compared with those which could maintain pregnancy under restricted feeding, total protein, albumin, platelets and antithrombin III values and especially blood progesterone concentration were significantly lower in aborted rabbits on GD 22, prior to occurrence of abortion. These results suggested that abortions due to restricted feeding might be brought about by lower nutritive conditions, an imbalance of blood coagulation-related factors and lower blood progesterone concentrations.
authors.affiliation: Kannami Laboratory, Bozo Research Center Inc., Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Matsuoka
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Mizuguchi
authors.forename: Yasumoto
authors.initials: Y
authors.lastname: Mizoguchi
authors.forename: Takako
authors.initials: T
authors.lastname: Endho
authors.forename: Ryo
authors.initials: R
authors.lastname: Kamata
authors.forename: Kazuya
authors.initials: K
authors.lastname: Fukuda
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Asano
mesh_terms: D000034:Abortion, Veterinary / Q000097:blood; D000818:Animals; D001774:Blood Chemical Analysis / Q000379:methods* / Q000706:statistics & numerical data; D001777:Blood Coagulation / Q000502:physiology; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests / Q000379:methods / Q000706:statistics & numerical data; D002585:Cesarean Section / Q000662:veterinary; D005260:Female; D005508:Food Deprivation; D005865:Gestational Age; D011247:Pregnancy; D011256:Pregnancy Outcome; D011270:Pregnancy, Animal / Q000097:blood*; D011374:Progesterone / Q000097:blood; D011817:Rabbits; D013997:Time Factors; D015430:Weight Gain; D015431:Weight Loss
chemical_list: D001779:Blood Coagulation Factors; D011374:Progesterone