title: Demonstration of 1-year duration of immunity for attenuated Bordetella bronchiseptica vaccines in dogs.
abstract: Three groups of healthy dogs with low antibody titers to Bordetella bronchiseptica (Bb), canine parainfluenza virus (CPI), and canine adenovirus type 2 (CAV-2) were used in this study. One group was vaccinated with a single dose of monovalent attenuated Bb vaccine and one group with a trivalent vaccine containing attenuated Bb, CPI, and CAV-2; dogs were vaccinated intranasally with a single dose of the respective vaccines. The third group served as unvaccinated controls. All vaccinated dogs subsequently developed serum antibody titers to Bb that persisted for at least 1 year. Following Bb challenge 1 year after vaccination, all vaccinated dogs, regardless of group, showed significantly fewer clinical signs and shed significantly fewer challenge organisms than unvaccinated controls. These results demonstrate that intranasal administration of a single dose of monovalent attenuated Bb vaccine or trivalent vaccine containing attenuated Bb, CPI, and CAV-2 provides 1 year of protection against Bb.
authors.affiliation: Intervet/Schering-Plough Animal Health, Elkhorn, NE 68022, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Lehar
authors.forename: Huchappa
authors.initials: H
authors.lastname: Jayappa
authors.forename: Jason
authors.initials: J
authors.lastname: Erskine
authors.forename: Alicia
authors.initials: A
authors.lastname: Brown
authors.forename: Diane
authors.initials: D
authors.lastname: Sweeney
authors.forename: Terri
authors.initials: T
authors.lastname: Wassmoen
mesh_terms: D000257:Adenoviridae Infections / Q000517:prevention & control / Q000662:veterinary; D006516:Adenoviruses, Canine / Q000276:immunology; D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D001885:Bordetella Infections / Q000517:prevention & control / Q000662:veterinary*; D016950:Bordetella bronchiseptica / Q000276:immunology*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D008297:Male; D022241:Parainfluenza Vaccines / Q000008:administration & dosage; D010223:Parainfluenza Virus 2, Human / Q000276:immunology; D011897:Random Allocation; D019351:Rubulavirus Infections / Q000517:prevention & control / Q000662:veterinary; D014613:Vaccines, Attenuated; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D001428:Bacterial Vaccines; D022241:Parainfluenza Vaccines; D014613:Vaccines, Attenuated; D014765:Viral Vaccines