title: Efficacy of ciprofloxacin in an experimental model of Escherichia coli chorioamnionitis in rabbits.
abstract: Pregnant rabbits were treated with ciprofloxacin alone or with gentamicin in a model of Escherichia coli chorioamnionitis, and the results were compared with those for untreated rabbits. The survival rate increased and the bacteremia decreased significantly in treated fetuses in comparison to controls (P = 0.003). Nevertheless, rapid selection of resistant mutants is a major limit to ciprofloxacin applications.
authors.affiliation: Département de Périnatologie, Hôpital Mère Enfant CHU Nantes, Nantes CEDEX 1, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Launay
authors.forename: Nicolas
authors.initials: N
authors.lastname: Joram
authors.forename: Cédric
authors.initials: C
authors.lastname: Jacqueline
authors.forename: Anne Francoise
authors.initials: AF
authors.lastname: Miegeville
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Caillon
authors.forename: Gilles
authors.initials: G
authors.lastname: Potel
authors.forename: Jean Christophe
authors.initials: JC
authors.lastname: Roze
authors.forename: Christèle
authors.initials: C
authors.lastname: Gras-Le Guen
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D002821:Chorioamnionitis / Q000188:drug therapy*; D002939:Ciprofloxacin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005260:Female; D005333:Fetus / Q000378:metabolism; D011247:Pregnancy; D011817:Rabbits
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin