title: Gefitinib in lung cancer therapy: clinical results, predictive markers of response and future perspectives.
abstract: Over the past few years, epidermal growth factor receptor has emerged as one of the most important targets in tumorgenesis and several drugs targeting signal transduction pathways have been developed. The first among these agents to be approved for the treatment of NSCLC was gefitinib, a potent, selective and reversible inhibitor of HER1/EGFR tyrosine kinase activity. The review summarizes its clinical development and the new therapeutic options, with particular focus on predictive markers of susceptibility to this drug.
authors.affiliation: Department of Human Pathology, Medical Oncology and Integrated Therapies Unit, University Policlinic G. Martino of Messina, Messina, Italy. vadamo@unime.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Adamo
authors.forename: Tindara
authors.initials: T
authors.lastname: Franchina
authors.forename: Barbara
authors.initials: B
authors.lastname: Adamo
authors.forename: Nerina
authors.initials: N
authors.lastname: Denaro
authors.forename: Pietro
authors.initials: P
authors.lastname: Gambadauro
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Chiofalo
authors.forename: Antonino
authors.initials: A
authors.lastname: Scimone
authors.forename: Nicola
authors.initials: N
authors.lastname: Caristi
authors.forename: Antonio
authors.initials: A
authors.lastname: Russo
authors.forename: Antonio
authors.initials: A
authors.lastname: Giordano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015415:Biomarkers; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000639:trends; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D000077156:Gefitinib; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D011799:Quinazolines / Q000627:therapeutic use*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D011799:Quinazolines; C512478:EGFR protein, human; D066246:ErbB Receptors; D000077156:Gefitinib