title: Development of a compact mock circulation system and a new flow-cell model for pulse spectrophotometry.
abstract: We have developed an extremely compact mock circulation system. This system can simulate artery blood circulation and generate a pulse wave with a very small amount of blood. We were also able to measure the in vitro pulsatile optical density ratio (Phivt) using this system with a flow cell [1]. Results showed a difference between Phivt and the in vivo pulsatile optical density ratio (Phivi) for the same oxygen saturations. To explain this difference, we proposed a new flow-cell model that includes venous flow and arterial flow. Because these systems can simulate the in vivo environment with very accurately, they can be applied to various pulse spectrophotometry studies. Moreover, the required blood volume is very small so the system can evaluate artificial blood or artificial red cells at very low cost. Thus, this system can reduce the time and cost of developing new pulse photometry techniques and other medical equipment.
authors.affiliation: Nihon Kohden Corporation, 1-31-4 Nishi-Ochiai, Shinjuku-ku, Tokyo, Japan. Mitsuhiro_Oura@mb1.nkc.co.jp
authors.forename: M
authors.initials: M
authors.lastname: Oura
authors.forename: N
authors.initials: N
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Iwasaki
authors.forename: M
authors.initials: M
authors.lastname: Umezu
mesh_terms: D001158:Arteries / Q000502:physiology*; D040761:Biomimetic Materials; D004867:Equipment Design; D019544:Equipment Failure Analysis / Q000295:instrumentation* / Q000379:methods; D017022:Flow Injection Analysis / Q000295:instrumentation*; D006801:Humans; D010092:Oximetry / Q000295:instrumentation* / Q000379:methods*; D011673:Pulsatile Flow / Q000502:physiology*; D013053:Spectrophotometry / Q000295:instrumentation* / Q000379:methods