title: Modification of autonomic balance by electrical acupuncture does not affect baroreflex dynamic characteristics.
abstract: BACKGROUND
  We have demonstrated that modification of autonomic balance by electrical vagal stimulation delays progression of cardiac dysfunction and cardiac remodeling, and prolongs survival in rats with severe heart failure. We have also shown that we were able to modify autonomic balance by electrical acupuncture at the acupoint of Zusanli, potentially applicable for the treatment of heart failure. We examined the effect of the acupuncture on the dynamic characteristics of the baroreflex system to exclude the possible deleterious effect on orthostatic tolerance.
  
  
  METHODS
  In anesthetized 8 and 6 rabbits, we examined static and dynamic characteristics of baroreflex, respectively, with and without electrical acupuncture (1 Hz, 5 mA, and 5msec). Dynamic characteristics were examined by imposing pseudorandom binary changes in isolated carotid sinus pressure.
  
  
  RESULTS
  With the stimulation condition to decrease arterial blood pressure and sympathetic nerve activity (resulted form decreased response range of neural arc), either of the dynamic characteristics of neural arc or those of peripheral arc did not change by electrical acupuncture at Zusanli.
  
  
  CONCLUSIONS
  We conclude that application of electrical acupuncture at Zusanli can suppress sympathetic nerve activity but does not affect the dynamic characteristics of the arterial baroreflex system, indicating no deleterious effect on orthostatic tolerance.
authors.affiliation: National Cardiovascular Center Research Institute, Suita, Osaka 5658565, Japan. su91mach@ri.ncvc.go.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Sugimachi
authors.forename: Toru
authors.initials: T
authors.lastname: Kawada
authors.forename: Hiromi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Atsunori
authors.initials: A
authors.lastname: Kamiya
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D015669:Acupuncture Points; D015670:Acupuncture Therapy / Q000379:methods*; D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D017704:Baroreflex / Q000502:physiology*; D001698:Biomedical Engineering; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D004856:Postural Balance / Q000502:physiology*; D011817:Rabbits; D014630:Vagus Nerve / Q000502:physiology