title: [Functional alteration of nervous system in renovascular hypertension].
abstract: The role of nitric oxide (NO)-containing nerves in adrenergic neurotransmission in hypertension was studied in mesenteric resistance arteries without endothelium in 2-kidney-1-clip renal hypertensive rats (2K-1C RHR) and sham-operated normotensive rats (Sham-R). Mesenteric vascular beds isolated from 2K-1C RHR and Sham-R were perfused with Krebs solution and changes in perfusion pressure were measured with a pressure transducer. Perfusion of a NO synthase inhibitor, N-omega-nitro-L-arginine methyl ester (L-NAME), markedly augmented vasoconstrictor responses to periarterial nerve stimulation (PNS) without affecting vasoconstriction induced by exogenously injected noradrenaline. L-NAME significantly increased the neurogenic release of NA evoked by PNS in both 2K-1C RHR and Sham-R preparations. The facilitatory effect of L-NAME based on the inhibition of NO production in 2K-1C RHR was less than that in Sham-R. These results suggest that the function of NO-containing nerves, which presynaptically inhibit adrenergic neurotransmission, is decreased in the renovascular hypertensive model rat.
authors.affiliation: Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Koyama
authors.forename: Yukako
authors.initials: Y
authors.lastname: Hatanaka
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Goda
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Zamami
authors.forename: Narumi
authors.initials: N
authors.lastname: Hobara
authors.forename: Hiromu
authors.initials: H
authors.lastname: Kawasaki
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D009569:Nitric Oxide