Organocatalytic asymmetric alkylation of aldehydes by S(N)1-type reaction of alcohols.
Work-alcoholic! The elusive enantioselective catalytic alpha-alkylation of aldehydes, a widely sought transformation, was brought to execution by the use of alcohols capable of forming stabilized carbocations (see scheme, TFA = trifluoroacetic acid).
Cozzi
Pier Giorgio
PG
Dipartimento di Chimica G. Ciamician, Alma Mater Studiorum Università di Bologna, Via Selmi 2, 40126, Italy. piergiorgio.cozzi@unibo.it
Benfatti
Fides
F
Zoli
Luca
L