title: Serum sFlt1:PlGF ratio, PlGF, and soluble endoglin levels in gestational proteinuria.
abstract: OBJECTIVE
  It was recently reported that both a high soluble fms-like tyrosine kinase 1 (sFlt1): placental growth factor (PlGF) ratio (sFlt1:PlGF ratio) and high soluble endoglin (sEng) levels are related to the later occurrence of preeclampsia. We compared the serum sFlt1:PlGF ratio, PlGF and sEng levels in women with gestational proteinuria (GP) to those in women with preeclampsia.
  
  
  METHODS
  Seven women with GP and 34 women with preeclampsia were recruited in this study. The 95(th) percentile values in the reference curves of sFlt1, sFlt1:PlGF ratio and sEng, and the 5(th) percentile values in the reference curve of PlGF were respectively set as the cutoff values.
  
  
  RESULTS
  The incidence rates of a high sFlt1:PlGF ratio, low PlGF and high sEng in women with GP were 57%, 29% and 86%, respectively, whereas those in women with preeclampsia were 94%, 77%, and 88%, respectively (p=0.028, p=0.024, and p=1.000, respectively). The incidence rates of a both high sFlt1:PlGF ratio and high sEng in women with GP and preeclampsia were 57% and 88%, respectively (p=0.082).
  
  
  CONCLUSIONS
  The majority of women with GP showed both increases of the sFlt1:PlGF ratio and sEng, thus suggesting some women with GP may represent subclinical preeclampsia. In addition, women with GP showed a significantly lower sFlt1:PlGF ratio and higher PlGF level than those with preeclampsia, suggesting that the PlGF level is a key regulator for developing hypertension in some pregnant women, even with increases of both sFlt1:PlGF ratio and sEng levels.
authors.affiliation: Department of Obstetrics and Gynecology, Jichi Medical University School of Medicine, Tochigi, Japan. okuchi@jichi.ac.jp
authors.forename: Akihide
authors.initials: A
authors.lastname: Ohkuchi
authors.forename: Chikako
authors.initials: C
authors.lastname: Hirashima
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsubara
authors.forename: Hirotada
authors.initials: H
authors.lastname: Suzuki
authors.forename: Kayo
authors.initials: K
authors.lastname: Takahashi
authors.forename: Rie
authors.initials: R
authors.lastname: Usui
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D000071063:Endoglin; D005260:Female; D006801:Humans; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011507:Proteinuria / Q000097:blood*; D011956:Receptors, Cell Surface / Q000097:blood*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood*
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D011956:Receptors, Cell Surface; D000072483:Placenta Growth Factor; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1