title: Benefits of intensive insulin therapy on neuromuscular complications in routine daily critical care practice: a retrospective study.
abstract: BACKGROUND
  Intensive insulin therapy (IIT) reduced the incidence of critical illness polyneuropathy and/or myopathy (CIP/CIM) and the need for prolonged mechanical ventilation (MV >or= 14 days) in two randomised controlled trials (RCTs) on the effect of IIT in a surgical intensive care unit (SICU) and medical intensive care unit (MICU). In the present study, we investigated whether these effects are also present in daily clinical practice when IIT is implemented outside of a study protocol.
  
  
  METHODS
  We retrospectively studied electrophysiological data from patients in the SICU and MICU, performed because of clinical weakness and/or weaning failure, before and after routine implementation of IIT. CIP/CIM was diagnosed by abundant spontaneous electrical activity on electromyography. Baseline and outcome variables were compared using Student's t-test, Chi-squared or Mann-Whitney U-test when appropriate. The effect of implementing IIT on CIP/CIM and prolonged MV was assessed using univariate analysis and multivariate logistic regression analysis (MVLR), correcting for baseline and ICU risk factors.
  
  
  RESULTS
  IIT significantly lowered mean (+/- standard deviation) blood glucose levels (from 144 +/- 20 to 107 +/- 10 mg/dl, p < 0.0001) and significantly reduced the diagnosis of CIP/CIM in the screened long-stay patients (125/168 (74.4%) to 220/452 (48.7%), p < 0.0001). MVLR identified implementing IIT as an independent protective factor (p < 0.0001, odds ratio (OR): 0.25 (95% confidence interval (CI): 0.14 to 0.43)). MVLR confirmed the independent protective effect of IIT on prolonged MV (p = 0.002, OR:0.40 (95% CI: 0.22-0.72)). This effect was statistically only partially explained by the reduction in CIP/CIM.
  
  
  CONCLUSIONS
  Implementing IIT in routine daily practice in critically ill patients evoked a similar beneficial effect on neuromuscular function as that observed in two RCTs. IIT significantly improved glycaemic control and significantly and independently reduced the electrophysiological incidence of CIP/CIM. This reduction partially explained the beneficial effect of IIT on prolonged MV.
authors.affiliation: Department of Internal Medicine, Medical Intensive Care Unit, University Hospitals Leuven, Catholic University Leuven, Leuven, Belgium. Greet.Hermans@uz.kuleuven.be
authors.forename: Greet
authors.initials: G
authors.lastname: Hermans
authors.forename: Maarten
authors.initials: M
authors.lastname: Schrooten
authors.forename: Philip
authors.initials: P
authors.lastname: Van Damme
authors.forename: Noor
authors.initials: N
authors.lastname: Berends
authors.forename: Bernard
authors.initials: B
authors.lastname: Bouckaert
authors.forename: Wouter
authors.initials: W
authors.lastname: De Vooght
authors.forename: Wim
authors.initials: W
authors.lastname: Robberecht
authors.forename: Greet
authors.initials: G
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D000368:Aged; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D005260:Female; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000473:pathology*; D011115:Polyneuropathies / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007328:Insulin