Protein kinase activation loop autophosphorylation in cis: overcoming a Catch-22 situation.
Autophosphorylation of the activation loop in cis is an underappreciated and poorly understood mode of activation of protein kinases. Here, I describe four examples of protein kinases that are activated in this way, concentrating on their biochemical properties and how their autophosphorylation in cis is achieved.
Lochhead
Pamela A
PA
The Laboratory of Molecular Signalling, The Babraham Research Institute, Babraham Research Campus, Cambridge CB22 3AT, UK. pamela.lochhead@bbsrc.ac.uk
D000255:Adenosine Triphosphate / Q000737:chemistry; D000818:Animals; D004789:Enzyme Activation; D051379:Mice; D008954:Models, Biological; D008958:Models, Molecular; D008968:Molecular Conformation; D010766:Phosphorylation; D011487:Protein Conformation; D011494:Protein Kinases / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000235:genetics*; D014443:Tyrosine / Q000737:chemistry
D014443:Tyrosine; D000255:Adenosine Triphosphate; D011494:Protein Kinases