Serum antibodies against Panton-Valentine leukocidin in a normal population and during Staphylococcus aureus infection.
To determine whether Staphylococcus aureus Panton-Valentine leukocidin (PVL) is expressed during human infection, anti-PVL antibody titres were compared in patients with PVL-positive and PVL-negative staphylococcal infections, and in patients with no evidence of S. aureus infection. Patients with PVL-positive strains had higher levels of anti-PVL antibodies than individuals of both control groups. The median anti-PVL titre increased 8.6-fold during the course of PVL-positive infection and 1.4-fold during PVL-negative infection. These results indicate that only PVL-positive S. aureus strains elicit significant anti-PVL antibody production in humans, and demonstrate the production of PVL during PVL-positive S. aureus infection. The protective role of this immune response remains to be established.
Croze
M
M
Centre National de Référence des Staphylocoques, INSERM U851, IFR128 Laennec, Université Lyon 1, Lyon.
Dauwalder
O
O
Dumitrescu
O
O
Badiou
C
C
Gillet
Y
Y
Genestier
A-L
AL
Vandenesch
F
F
Etienne
J
J
Lina
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000097:blood*; D001427:Bacterial Toxins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005098:Exotoxins / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007956:Leukocidins / Q000276:immunology*; D008875:Middle Aged; D044967:Serum / Q000276:immunology*; D013203:Staphylococcal Infections / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*; D055815:Young Adult
D000907:Antibodies, Bacterial; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin