Temporal appearance of plasmid-mediated quinolone resistance genes.
One hundred fifty AAC(6')-Ib-positive gram-negative isolates collected between 1981 and 1991 were examined by PCR for the presence of the aac(6')-Ib-cr variant and other plasmid-mediated quinolone resistance (PMQR) genes. None had the aac(6')-Ib-cr variant, qnrA, qnrS, qnrC, or qepA, but two strains collected in 1988 had qnrB alleles, making these the earliest known PMQR genes.
Jacoby
George A
GA
Lahey Clinic, Burlington, Massachusetts, USA. george.a.jacoby@lahey.org
Gacharna
Nancy
N
Black
Todd A
TA
Miller
George H
GH
Hooper
David C
DC
D000123:Acetyltransferases / Q000235:genetics*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D029968:Escherichia coli Proteins / Q000235:genetics; D010957:Plasmids; D016133:Polymerase Chain Reaction; D011804:Quinolines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; C485384:Qnr protein, E coli; D011804:Quinolines; D000123:Acetyltransferases; C443113:aminoglycoside 2'-N-acetyltransferase