title: Efficacy of lasalocid against coccidiosis in Chinese ring-necked pheasants.
abstract: Two battery efficacy studies were conducted with field isolates of Eimeria spp. from outbreaks of coccidiosis on pheasant-rearing farms in Georgia (GA) and Illinois (IL), United States. The coccidian isolates were mixed species containing E. phasiani, E duodenalis, and E colchici. Lasalocid (LAS) was tested prophylactically at 120 parts per million (ppm) in the feed. Anticoccidial activity was assessed, in comparisons between infected and uninfected control birds, by the effects on weight gain and oocyst passage. The GA isolate reduced weight gain of infected controls by 64% (P < 0.05) during the week after inoculation. LAS-treated birds also suffered some depressed gain, but average gains were significantly improved (P < 0.05) in comparison with that of the infected controls. Fecal oocyst counts of infected controls averaged 10-24 x 10(6)/day for days 5-11 postinoculation (PI), after which oocyst passage declined. Birds given LAS passed 10-20 x 10(6) oocysts on days 5-6 PI, after which counts dropped to much lower levels. Oocyst passage was significantly reduced (P < 0.05) by LAS treatment on all but days 5 and 6 PI. The IL isolate reduced weight gain by 36% in infected controls, relative to uninfected controls (P < 0.05). LAS-treated birds also suffered reduced gain, but the gain was significantly improved in comparison with the infected controls. Oocyst counts averaged 3-9 x 10(6)/day on days 6-14 PI, but were significantly reduced by LAS treatment on all but day 6 PI. Thus, LAS was effective in pheasants against the tested field isolates of Eimeria spp. and was well tolerated at 120 ppm in the feed. However, the level of control was not as high as previously observed. Possible explanations for this difference include an emergence of drug resistance from prior use of LAS and a differential efficacy of LAS against different species of Eimeria used in the studies.
authors.affiliation: Department of Poultry Science, University of Georgia, Athens, GA 30602, USA.
authors.forename: L
authors.initials: L
authors.lastname: Fuller
authors.forename: R
authors.initials: R
authors.lastname: Griffeth
authors.forename: L R
authors.initials: LR
authors.lastname: McDougald
mesh_terms: D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D046094:Galliformes; D007832:Lasalocid / Q000627:therapeutic use*; D010270:Parasite Egg Count / Q000662:veterinary; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D015430:Weight Gain
chemical_list: D003049:Coccidiostats; D007832:Lasalocid