Cytotoxic sorbicillinoids and bisorbicillinoids from a marine-derived fungus Trichoderma sp.
Four sorbicillinoids (1-4) and seven bisorbicillinoids (5-11), including two new compounds, 6-demethylsorbicillin (1) and 10,11-dihydrobisvertinolone (6), were isolated from a marine-derived fungus Trichoderma sp. Their cytotoxic activities against HL-60 cell line were evaluated by Sulforhodamine B (SRB) assay method and flow cytometric analysis.
Du
Lin
L
Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qindao, China.
Zhu
Tianjiao
T
Li
LiYuan
L
Cai
Shengxin
S
Zhao
Boyu
B
Gu
Qianqun
Q
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology*; D002942:Circular Dichroism; D005285:Fermentation; D005434:Flow Cytometry; D018922:HL-60 Cells; D006801:Humans; D007659:Ketones / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013172:Spores, Fungal; D014242:Trichoderma / Q000737:chemistry*
D000903:Antibiotics, Antineoplastic; D007659:Ketones; D012118:Resorcinols