title: Associations between lamb survival and prion protein genotype: analysis of data for ten sheep breeds in Great Britain.
abstract: BACKGROUND
  Selective breeding programmes, based on prion protein (PrP) genotype, have been introduced throughout the European Union to reduce the risk of sheep transmissible spongiform encephalopathies (TSEs). These programmes could have negative consequences on other important traits, such as fitness and production traits, if the PrP gene has pleiotropic effects or is in linkage disequilibrium with genes affecting these traits. This paper presents the results of an investigation into associations between lamb survival and PrP genotype in ten mainstream sheep breeds in Great Britain (GB). In addition, the reasons for lamb deaths were examined in order to identify any associations between these and PrP genotype.
  
  
  RESULTS
  Survival times from birth to weaning were analysed for over 38000 lambs (2427 dead and 36096 live lambs) from 128 flocks using Cox proportional hazard models for each breed, including additive animal genetic effects. No significant associations between PrP genotype and lamb survival were identified, except in the Charollais breed for which there was a higher risk of mortality in lambs of the ARR/VRQ genotype compared with those of the ARR/ARR genotype. Significant effects of birth weight, litter size, sex, age of dam and year of birth on survival were also identified. For all breeds the reasons for death changed significantly with age; however, no significant associations between reason for death and PrP genotype were found for any of the breeds.
  
  
  CONCLUSIONS
  This study found no evidence to suggest that a selective breeding programme based on PrP genotype will have a detrimental effect on lamb survival. The only significant effect of PrP genotype identified was likely to be of little consequence because an increased risk of mortality was associated with a genotype that is selected against in current breeding strategies.
authors.affiliation: Centre for Epidemiology and Risk Analysis, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey, KT15 3NB, UK. simon.gubbins@bbsrc.ac.uk
authors.forename: Simon
authors.initials: S
authors.lastname: Gubbins
authors.forename: Charlotte J
authors.initials: CJ
authors.lastname: Cook
authors.forename: Kieran
authors.initials: K
authors.lastname: Hyder
authors.forename: Kay
authors.initials: K
authors.lastname: Boulton
authors.forename: Carol
authors.initials: C
authors.lastname: Davis
authors.forename: Eurion
authors.initials: E
authors.lastname: Thomas
authors.forename: Will
authors.initials: W
authors.lastname: Haresign
authors.forename: Stephen C
authors.initials: SC
authors.lastname: Bishop
authors.forename: Beatriz
authors.initials: B
authors.lastname: Villanueva
authors.forename: Rachel D
authors.initials: RD
authors.lastname: Eglin
mesh_terms: D000818:Animals; D001947:Breeding; D005260:Female; D005838:Genotype; D008297:Male; D011328:Prions / Q000235:genetics*; D012756:Sheep / Q000235:genetics*; D016019:Survival Analysis; D006113:United Kingdom
chemical_list: D011328:Prions