title: Effects of chronic mild stress on the oxidative parameters in the rat brain.
abstract: Major depression is characterized for symptoms at the psychological, behavioral and physiological levels. The chronic mild stress model has been used as an animal model of depression. The consumption of sweet food, locomotor activity, body weight, lipid and protein oxidation levels and superoxide dismutase and catalase activities in the rat hippocampus, prefrontal cortex and cortex were assessed in rats exposed to chronic mild stress. Our findings demonstrated a decrease on sweet food intake, no effect on locomotor activity, lack of body weight gain, increase in protein (prefrontal, hippocampus, striatum and cortex) and lipidic peroxidation (cerebellum and striatum), and an increase in catalase (cerebellum, hippocampus, striatum, cortex) and a decrease in superoxide dismutase activity (prefrontal, hippocampus, striatum and cortex) in stressed rats. In conclusion, our results support the idea that stress produces oxidants and an imbalance between superoxide dismutase and catalase activities that contributes to stress-related diseases, such as depression.
authors.affiliation: Instituto Nacional de Ciência e Tecnologia Translacional em Medicina, Universidade do Extremo Sul Catarinense, Criciúma, Criciúma, SC, Brazil.
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Lucca
authors.forename: Clarissa M
authors.initials: CM
authors.lastname: Comim
authors.forename: Samira S
authors.initials: SS
authors.lastname: Valvassori
authors.forename: Gislaine Z
authors.initials: GZ
authors.lastname: Réus
authors.forename: Francieli
authors.initials: F
authors.lastname: Vuolo
authors.forename: Fabrícia
authors.initials: F
authors.lastname: Petronilho
authors.forename: Felipe
authors.initials: F
authors.lastname: Dal-Pizzol
authors.forename: Elaine C
authors.initials: EC
authors.lastname: Gavioli
authors.forename: João
authors.initials: J
authors.lastname: Quevedo
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism* / Q000503:physiopathology; D001923:Brain Chemistry / Q000502:physiology*; D002374:Catalase / Q000378:metabolism; D002908:Chronic Disease; D003866:Depressive Disorder / Q000378:metabolism* / Q000503:physiopathology; D004195:Disease Models, Animal; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism* / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D016877:Oxidants; D017382:Reactive Oxygen Species; D002374:Catalase; D013482:Superoxide Dismutase