title: Extramedullary myeloma in an HIV-seropositive subject. Literature review and report of an unusual case.
abstract: Myeloma is characterized by monoclonal bone marrow plasmacytosis, the presence of M-protein in serum and/or in urine and osteolytic bone lesions. HIV-seropositive subjects with myeloma are younger at the time of diagnosis of the tumour and usually the myeloma has a more aggressive clinical course than it does in HIV-seronegative subjects. A case of an HIV-seropositive woman in whom myeloma was diagnosed following progressive swelling of the face, is reported. In addition to bone marrow plasmacytosis and the presence of M-protein in the serum, the patient had an extramedullary lesion affecting the oral cavity, maxilla, parotid gland and paranasal sinuses, and extending intracranially and intraorbitally.
authors.affiliation: Department of Periodontology and Oral Medicine, School of Dentistry, University of Limpopo, Pretoria, South Africa. lfeller@ul.ac.za
authors.forename: Liviu
authors.initials: L
authors.lastname: Feller
authors.forename: Jason
authors.initials: J
authors.lastname: White
authors.forename: Neil H
authors.initials: NH
authors.lastname: Wood
authors.forename: Michael
authors.initials: M
authors.lastname: Bouckaert
authors.forename: Johan
authors.initials: J
authors.lastname: Lemmer
authors.forename: Erich J
authors.initials: EJ
authors.lastname: Raubenheimer
mesh_terms: D005153:Facial Neoplasms / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis