title: Successful renal re-transplantation in the presence of pre-existing anti-DQ5 antibodies when there was zero mismatch at class I human leukocyte antigen A, B, & C: a case report.
abstract: BACKGROUND
  Hyperacute rejection may be prevented by avoiding the transplantation of kidneys into patients with pre-existing anti-donor Class I human leukocyte antigen antibodies. However, the role of anti-donor-Class II-human leukocyte antigen-DQ antibodies is not established. The question is ever more relevant as more sensitive cross-matching techniques detect many additional antibodies during the final crossmatch. We now report successful renal transplantation of a patient who had pre-existing antibodies against his donor's human leukocyte antigen-DQ5.
  
  
  METHODS
  Our patient, a Caucasian man, was 34 years of age when he received his first deceased donor renal transplant. After 8 years, his first transplant failed from chronic allograft dysfunction and an earlier bout of Banff 1A cellular rejection. The second deceased donor kidney transplant was initially allocated to the patient due to a 0 out of 6 mismatch. The B cell crossmatch was mildly positive, while the T Cell crossmatch was negative. Subsequent assays showed that the patient had preformed antibodies for human leukocyte antigen DQ5 against his second donor. Despite having preformed antibodies against the donor, the patient continues to have excellent allograft function two years after his second renal transplant.
  
  
  CONCLUSIONS
  The presence of pre-existing antibodies against human leukocyte antigen DQ5 does not preclude transplantation. The relevance of having other antibodies against class II human leukocyte antigens prior to transplantation remains to be studied.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas, USA. Christopher.lu@utsouthwestern.edu.
authors.forename: John
authors.initials: J
authors.lastname: Hartono
authors.forename: Bhavna
authors.initials: B
authors.lastname: Lavingia
authors.forename: Peter
authors.initials: P
authors.lastname: Stastny
authors.forename: Martin
authors.initials: M
authors.lastname: Senitko
authors.forename: Miguel
authors.initials: M
authors.lastname: Vazquez
authors.forename: Juan
authors.initials: J
authors.lastname: Arenas
authors.forename: Christopher
authors.initials: C
authors.lastname: Lu