A new antioxidant, clitocybin A, from the culture broth of Clitocybe aurantiaca.
Clitocybin A (1), a new antioxidant, was isolated from the culture broth of Clitocybe aurantiaca. This compound was purified by solvent extraction, silica gel column chromatography, Sephadex LH-20 column chromatography and preparative HPLC. Its structure was determined as 4,6-dihydroxy-2-p-hydroxyphenyl-isoindol1-one on the basis of the UV, NMR, and MS spectroscopic analysis. The compound 1 showed potent free radical scavenging activity against superoxide, ABTS, and DPPH radicals, and protective effect against cellular DNA damage induced by oxidative stress.
Kim
Young-Hee
YH
Functional Metabolomics Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.
Cho
Sung-Min
SM
Hyun
Jin-Won
JW
Ryoo
In-Ja
IJ
Choo
Soo-Jin
SJ
Lee
Sangku
S
Seok
Soon-Ja
SJ
Hwang
Jae Sung
JS
Sohn
Eui Dong
ED
Yun
Bong-Sik
BS
Bae
Ki Hwan
KH
Yoo
Ick-Dong
ID
D000363:Agaricales / Q000378:metabolism*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004249:DNA Damage / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology; D054833:Isoindoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000975:Antioxidants; D016166:Free Radical Scavengers; D054833:Isoindoles; C535086:clitocybin A