Electrochemotherapy-induced radiation recall in a cat.
Electrochemotherapy is gaining popularity for the treatment of malignancies of companion animals due to its efficacy and low cost. In this paper, we describe the successful treatment of a recurring fibrosarcoma in a cat by using cisplatin selectively driven within the tumor cells by trains of biphasic pulses. The cat's tumor did not recur over the following five months, however the cat did experience severe erythema at the site of previous irradiation, followed by moist desquamation and ulcer that required debridement and prolonged therapy with steroids and antihistaminic drugs. The symptoms and the response to symptomatic therapy were strongly suggestive of radiation recall. Electrochemotherapy (ECT) should be used with caution in previously irradiated areas. Further studies are warranted in this field due to its potential as a rescue for relapsing tumors.
Spugnini
Enrico P
EP
S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy. info@enricospugnini.net
Dotsinsky
Ivan
I
Mudrov
Nikolay
N
Citro
Gennaro
G
Caruso
Giovanni
G
Cardelli
Pierluigi
P
Baldi
Alfonso
A
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001706:Biopsy; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002945:Cisplatin / Q000627:therapeutic use*; D053672:Electrochemotherapy / Q000379:methods* / Q000662:veterinary; D005354:Fibrosarcoma / Q000188:drug therapy* / Q000662:veterinary; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D009919:Orchiectomy; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D002945:Cisplatin