title: Quantitative accuracy of delayed hyperperfusion in MRI of transient ischemia in rats.
abstract: A strong hyperperfusion was reported in transient ischemic tissue between 48 and 72 hours after middle cerebral artery occlusion (MCAO). Cerebral blood flow (CBF) estimated by continuous arterial spin labeling (CASL) with short delay after tagging was sensitive to cerebral blood volume (CBV) change. The delayed hyperperfusion may indicate a CBV increase after MCAO. For confirmation of the delayed hyperperfusion, we investigated a transit-time dependency in CASL at two days after MCAO. We also acquired CBF using the dynamic susceptibility contrast (DSC) at the same day. We have confirmed the CBF in transient ischemic tissue is quite higher (179.1+/-21.6 ml/100g/min) than normal tissue (121.0+/-6.9 ml/100g/min) with CASL using tagging delay of 0.4 sec. CBF estimated by DSC also show delayed hyperperfusion in transient ischemic tissue. These results confirm existence of physiological delayed hyperperfusion in transient ischemic area.
authors.affiliation: Akita Research Institute for brain and blood vessels, Akita 010-0874, Japan. knam@akita-noken.go.jp
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Nakamura
authors.forename: David
authors.initials: D
authors.lastname: Wright
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kondoh
authors.forename: Shigenori
authors.initials: S
authors.lastname: Mizusawa
authors.forename: Toshibumi
authors.initials: T
authors.lastname: Kinoshita
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015428:Myocardial Reperfusion Injury; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity