Xp11.2 translocation renal carcinoma with placental metastasis: a case report.
Renal cell carcinomas with sporadic Xp11.2 translocations are uncommon malignancies in children and young adults associated with several different reciprocal translocations involving the TFE3 gene located on chromosome Xp11.2. Placental metastases are extremely rare, with only a handful of cases reported. This study reports the case of a 20-year-old woman with an Xp11.2 translocation renal carcinoma that metastasized to the placenta. This is the first reported case of a renal cell carcinoma metastatic to the placenta and highlights the aggressive behavior of Xp11 translocation renal cell carcinomas.
Bovio
Ian M
IM
Department of Pathology, College of Medicine, University of Florida, Gainesville, Florida, USA. boviim@pathology.ufl.edu
Allan
Robert W
RW
Oliai
Bahram R
BR
Hampton
Troy
T
Rush
Demaretta S
DS
D000328:Adult; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000556:secondary*; D002585:Cesarean Section; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000473:pathology*; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000235:genetics / Q000473:pathology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000235:genetics / Q000473:pathology*; D014178:Translocation, Genetic