title: Late vitamin K deficiency bleeding after intramuscular prophylaxis at birth: a case report.
abstract: We report the case of a 6-week-old female who presented an intracranial hemorrhage due to late vitamin K deficiency bleeding (VKDB). No other evident bleeding sites were present at the moment of diagnosis. Intramuscular vitamin K (1 mg) was administered at birth. She was exclusively breast-fed. No other risk factors for VKDB were detected. Low levels of vitamin K-dependent coagulation factors and their normalization after vitamin K administration confirmed the diagnosis of late VKDB. The present case suggests potential risks related to a single dose of intramuscular vitamin K at birth.
authors.affiliation: Division of Neonatology, University of Pisa, Pisa, Italy. m.ciantelli@libero.it
authors.forename: M
authors.initials: M
authors.lastname: Ciantelli
authors.forename: L
authors.initials: L
authors.lastname: Bartalena
authors.forename: M
authors.initials: M
authors.lastname: Bernardini
authors.forename: P
authors.initials: P
authors.lastname: Biver
authors.forename: F
authors.initials: F
authors.lastname: Chesi
authors.forename: A
authors.initials: A
authors.lastname: Boldrini
authors.forename: E
authors.initials: E
authors.lastname: Sigali
mesh_terms: D017668:Age of Onset; D000933:Antifibrinolytic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D020300:Intracranial Hemorrhages / Q000209:etiology*; D016896:Treatment Outcome; D014812:Vitamin K / Q000008:administration & dosage*; D014813:Vitamin K Deficiency / Q000150:complications*
chemical_list: D000933:Antifibrinolytic Agents; D014812:Vitamin K