Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11.
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structure of viridicatumtoxin B was determined on the basis of MS and NMR data. Viridicatumtoxin B inhibited the growth of Staphylococcus aureus including methicillin-resistant S. aureus and quinolone-resistant S. aureus with MIC (microg/ml) of 0.5, which is similar with that of vancomycin, but 8-64 times higher activity than that of tetracycline.
Zheng
Chang-Ji
CJ
Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Yu
Hyung-Eun
HE
Kim
Eun-Hee
EH
Kim
Won-Gon
WG
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010407:Penicillium / Q000737:chemistry* / Q000302:isolation & purification; D012988:Soil Microbiology; D013754:Tetracyclines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D009183:Mycotoxins; D013754:Tetracyclines; C539435:viridicatumtoxin B; C042170:viridicatumtoxin