[Xianling Gubao Capsule improves semen quality].
OBJECTIVE
To observe the effect of the compound Chinese traditional drug Xianling Gubao Capsule on the semen quality of infertile males.


METHODS
We treated 66 infertile men with Xianling Gubao Capsule for 24 months, and analyzed the semen quality and sperm morphology before and after the treatment.


RESULTS
Two months after the medication, sperm concentration was increased by a small margin, but no statistically significant changes were observed in sperm vitality and motility (P > 0.05), the rate of morphologically normal sperm was significantly raised from 25.8% before treatment to 57.6% (P < 0.05) in those with the normal rate > or = 15%, but decreased from 53.0% to 25.8% (P < 0.05) in those with the normal rate < 9%. Among the 7 cases of oligospermia, the rate of morphologically normal sperm was elevated to an average of 10.9% after the 4-month medication, significantly different from the baseline rate of 5.8% (P < 0.05). Five spontaneous pregnancies and 1 successful IVF-ICSI were achieved during the treatment.


CONCLUSIONS
Xianling Gubao Capsule can improve semen quality and significantly increase the percentage of morphologically normal sperm.
Jiang
Min
M
Human Sperm Bank, Huaxi Second Hospital of Sichuan University, Chengdu, Sichuan 610041, China.
Han
Zi-Yan
ZY
Yue
Huan-Xun
HX
Li
Fu-Ping
FP
Lin
Li
L
She
Wen-Jing
WJ
D000328:Adult; D002214:Capsules; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D011247:Pregnancy; D055101:Semen Analysis; D013076:Sperm Count; D013081:Sperm Motility; D016896:Treatment Outcome
D002214:Capsules