title: Obstetric complications as a risk factor for first psychotic episodes in childhood and adolescence.
abstract: There are reports of significant association between obstetric complications (OC) and childhood psychosis. Authors conducted a case-control study of 102 children and adolescents with a first episode psychosis (FEP) and 94 healthy controls (HC), using the obstetric complications scale (OCS) and their medical records, to examine the risk of FPE. Patients were recruited from child and adolescent psychiatry units at six university hospitals and controls from publicly-funded schools of similar characteristics and from the same geographic areas. A logistic regression was performed to quantify the risk of psychosis in childhood and adolescence, based on OC, adjusting for potential confounding factors like socio economic status (SES) and family psychiatric history (FPH). OC appeared more frequently in the records of patients. Significant differences between patients and controls were found in Prenatal OC (15.7% vs. 5.3%, P < 0.05) and among them, bleeding in pregnancy showed the greatest difference between groups (12.7% vs. 2.1%, P < 0.01). In the logistic regression, bleeding in pregnancy showed a crude odds ratio (OR) of 6.7 (95%CI = 1.4-30.6) and 5.1 (CI 95% = 1.0-24.9) adjusted for SES and FPH. Therefore, bleeding in pregnancy is a likely risk factor for early-onset psychosis.
authors.affiliation: Dept of Psychiatry, Adolescent Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. lolamoreno@hggm.es
authors.forename: Dolores
authors.initials: D
authors.lastname: Moreno
authors.forename: Miguel
authors.initials: M
authors.lastname: Moreno-Iñiguez
authors.forename: Dolores
authors.initials: D
authors.lastname: Vigil
authors.forename: Josefina
authors.initials: J
authors.lastname: Castro-Fornieles
authors.forename: Felipe
authors.initials: F
authors.lastname: Ortuño
authors.forename: Ana
authors.initials: A
authors.lastname: González-Pinto
authors.forename: Mara
authors.initials: M
authors.lastname: Parellada
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Baeza
authors.forename: Soraya
authors.initials: S
authors.lastname: Otero
authors.forename: Montserrat
authors.initials: M
authors.lastname: Graell
authors.forename: Ana
authors.initials: A
authors.lastname: Aldama
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D007744:Obstetric Labor Complications / Q000453:epidemiology*; D011247:Pregnancy; D011618:Psychotic Disorders / Q000453:epidemiology*; D012307:Risk Factors; D012959:Socioeconomic Factors