title: [Evaluation of depth of invasion and tumor diameter in relation to tumor localization in laryngeal cancer].
abstract: OBJECTIVE
  We investigated the relationship between tumor localization and depth of tumor invasion and tumor diameter.
  
  
  METHODS
  Neck dissection specimens of 70 patients (mean age 61+/-10 years, range 38 to 77 years) who underwent laryngectomy for squamous cell carcinoma of the larynx were histopathologically re-examined with regard to the number and localization of metastatic lymph nodes, depth of tumor invasion, and tumor diameter. Three tumor groups (supraglottic, glottic, and transglottic) were compared with respect to depth of tumor invasion, tumor diameter, metastatic lymph nodes, and T-stage.
  
  
  RESULTS
  The overall mean depth of tumor invasion was 7.06 mm, being 7.76 mm, 7.05 mm, and 4.06 mm in supraglottic, transglottic, and glottic tumors, respectively. Compared to glottic tumors, depth of tumor invasion and tumor diameter were significantly higher in supraglottic and transglottic tumors (p<0.05). Depth of invasion showed a significant correlation with tumor diameter (p<0.05), whereas there was no correlation between depth of invasion and lymph node metastasis (p>0.05). In supraglottic tumors, depth of invasion significantly increased in parallel with T-stage (p<0.05). In transglottic and glottic tumors, however, there was no correlation between T-stage and depth of invasion (p>0.05).
  
  
  CONCLUSIONS
  Our data show that depth of tumor invasion is related with tumor location and diameter in laryngeal cancers.
authors.affiliation: Department of Otolaryngology, Izmir Atatürk Training and Research Hospital, Izmir, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ersoy
authors.forename: Ercan
authors.initials: E
authors.lastname: Pinar
authors.forename: Cağlar
authors.initials: C
authors.lastname: Calli
authors.forename: Semih
authors.initials: S
authors.lastname: Oncel
authors.forename: Aylin
authors.initials: A
authors.lastname: Calli
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009361:Neoplasm Invasiveness