Cassane diterpenes from Caesalpinia bonduc.
Three cassane diterpene hemiketals, caesalpinolide-C, caesalpinolide-D, caesalpinolide-E and one cassane furanoditerpene were isolated from Caesalpinia bonduc. The molecular structures were elucidated using NMR spectroscopy in combination with IR, UV and mass spectral data and relative stereochemistries were determined through ROESY correlation. The isolated compounds were tested for their antiproliferative activity against MCF-7 (breast adenocarcinoma), DU145 (prostate carcinoma), C33A (Cervical carcinoma) and Vero (African green monkey kidney fibroblast) cells.
Yadav
Prem P
PP
Medicinal and Process Chemistry Division, Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India. pp_yadav@cdri.res.in
Maurya
Ranjani
R
Sarkar
Jayanta
J
Arora
Ashish
A
Kanojiya
Sanjeev
S
Sinha
Sudhir
S
Srivastava
M N
MN
Raghubir
Ram
R
D000818:Animals; D029911:Caesalpinia / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure
D004224:Diterpenes