Salmonella takes control: effector-driven manipulation of the host.
Salmonella pathogenesis relies upon the delivery of over thirty specialised effector proteins into the host cell via two distinct type III secretion systems. These effectors act in concert to subvert the host cell cytoskeleton, signal transduction pathways, membrane trafficking and pro-inflammatory responses. This allows Salmonella to invade non-phagocytic epithelial cells, establish and maintain an intracellular replicative niche and, in some cases, disseminate to cause systemic disease. This review focuses on the actions of the effectors on their host cell targets during each stage of Salmonella infection.
McGhie
Emma J
EJ
University of Cambridge, Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK. ejm37@cam.ac.uk
Brawn
Lyndsey C
LC
Hume
Peter J
PJ
Humphreys
Daniel
D
Koronakis
Vassilis
V
D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism*; D004847:Epithelial Cells / Q000382:microbiology*; D006801:Humans; D012475:Salmonella / Q000472:pathogenicity*; D037521:Virulence Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D037521:Virulence Factors