title: Monte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility.
abstract: Microbeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucléaires de Bordeaux-Gradignan in France, using the object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.
authors.affiliation: CNRS/IN2P3, Centre d'Etudes Nucléaires de Bordeaux-Gradignan, UMR 5797, Gradignan F-33175, France. incerti@cenbg.in2p3.fr
authors.forename: S
authors.initials: S
authors.lastname: Incerti
authors.forename: H
authors.initials: H
authors.lastname: Seznec
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: Ph
authors.initials: P
authors.lastname: Barberet
authors.forename: C
authors.initials: C
authors.lastname: Habchi
authors.forename: Ph
authors.initials: P
authors.lastname: Moretto
mesh_terms: D000465:Algorithms; D002468:Cell Physiological Phenomena / Q000528:radiation effects*; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009010:Monte Carlo Method; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*