title: Increased -1 ribosomal frameshifting efficiency by yeast prion-like phenotype [PSI+].
abstract: Programmed -1 ribosomal frameshifting (-1RF) is usually regulated by a slippery sequence and an RNA secondary structure but can be affected by the slippery sequence combined with translational perturbation. Dramatic increases of -1RF efficiencies arise from the slippery sequences in [PSI+], an epigenetic modifier of translation termination fidelity. Curing of [PSI+] abolished such increases of -1RF efficiency. Enhanced -1RF frequency at the slippery sequences could be another physiological effect induced directly or indirectly by the perturbation of the translation process in [PSI+] cells.
authors.affiliation: Department of Chemistry, School of Natural Sciences, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors.forename: Hee Jung
authors.initials: HJ
authors.lastname: Park
authors.forename: So Jung
authors.initials: SJ
authors.lastname: Park
authors.forename: Doo-Byoung
authors.initials: DB
authors.lastname: Oh
authors.forename: Sangho
authors.initials: S
authors.lastname: Lee
authors.forename: Yang-Gyun
authors.initials: YG
authors.lastname: Kim
mesh_terms: D001483:Base Sequence; D018965:Frameshifting, Ribosomal / Q000235:genetics*; D017930:Genes, Reporter; D005822:Genetic Vectors; D019791:Guanidine / Q000494:pharmacology; D049409:Luciferases, Firefly / Q000235:genetics / Q000378:metabolism; D049410:Luciferases, Renilla / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D010957:Plasmids; D011328:Prions / Q000235:genetics*; D014176:Protein Biosynthesis; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D011328:Prions; D011993:Recombinant Fusion Proteins; D049410:Luciferases, Renilla; D049409:Luciferases, Firefly; D019791:Guanidine