title: Room-temperature palladium-catalyzed C-H activation: ortho-carbonylation of aniline derivatives.
abstract: Pd and CO--ureally got me! The title reaction proceeds efficiently at 18 degrees C under CO (1 atm) with 5 % [Pd(OTs)(2)(MeCN)(2)] as precatalyst. Depending on the solvents used, either anthranilates or cyclic imides can be obtained in high yields (see picture, BQ = benzoquinone, Ts = 4-toluenesulfonyl).
authors.affiliation: School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
authors.forename: Chris E
authors.initials: CE
authors.lastname: Houlden
authors.forename: Marc
authors.initials: M
authors.lastname: Hutchby
authors.forename: Chris D
authors.initials: CD
authors.lastname: Bailey
authors.forename: J Gair
authors.initials: JG
authors.lastname: Ford
authors.forename: Simon N G
authors.initials: SN
authors.lastname: Tyler
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné
authors.forename: Guy C
authors.initials: GC
authors.lastname: Lloyd-Jones
authors.forename: Kevin I
authors.initials: KI
authors.lastname: Booker-Milburn
mesh_terms: D000814:Aniline Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D007096:Imidoesters / Q000138:chemical synthesis / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013696:Temperature; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D007096:Imidoesters; D062367:ortho-Aminobenzoates; D010165:Palladium; D002248:Carbon Monoxide; C038892:methyl anthranilate; C023650:aniline