Coronary heart disease and HRT in France: MISSION study prospective phase results.
OBJECTIVE
To determine the morbidity incidence associated with Hormone Replacement Therapy (HRTs) in postmenopausal women. This paper presents the results concerning the incidence of coronary heart disease (CHD).


METHODS
MISSION study started on 5 January 2004, the cutoff for data collection was June 2006 (follow-up no. 1). 'Exposed group': postmenopausal women currently on HRT, commonly prescribed in France or stopped < or =5 years previously. 'Unexposed group': never received HRT or stopped >5 years previously.


RESULTS
Data were available for 4949 patients (without CHD at the beginning of the follow-up): 2693 Exposed group and 2256 Unexposed group. The incidence during follow-up no. 1 of postmenopausal CHD was not significantly different in the Exposed group (0.11%) compared with the Unexposed group (0.13%). In the Exposed group the time between start of HRT and menopause was 2.93 +/- 4.46 years in those who experienced CHD and 1.53 +/- 3.20 years in those who had no incidence of CHD (p = 0.3).


CONCLUSIONS
In the MISSION cohort, no increased risk of CHD was found in the Exposed group compared with the Unexposed group.
Mares
Pierre
P
Service de Gynecologie Obstetrique, CHU Hopital Caremeau, Nimes, France.
Chevallier
Thierry
T
Micheletti
Marie-Christine
MC
Daures
Jean-Pierre
JP
Postruznik
Drazen
D
De Reilhac
Pia
P
D015331:Cohort Studies; D003327:Coronary Disease / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D005602:France / Q000453:epidemiology; D020249:Hormone Replacement Therapy / Q000706:statistics & numerical data*; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk