title: In vitro cyto-biocompatibility and cell detachment of temperature-sensitive dextran hydrogel.
abstract: A series of poly(NIPAAm-co-GMA-Dex) hydrogels were synthesized from glycidyl methacrylate-derivatized dextran (GMA-Dex) and N-isopropylacrylamide (NIPAAm) in aqueous solution. The swelling properties, cell culture and detachment behaviors of these hydrogels were investigated. It has found that poly(NIPAAm-co-GMA-Dex) hydrogels are not only sensitive to temperature in deionized water and Dulbecco's modified eagle medium (DMEM) (10% FBS), but also exhibit good biocompatibility. In addition, L929 cells were found to detach from the hydrogel surface naturally without affecting the function of L929 by controlling environmental temperature.
authors.affiliation: Tianjin Key Laboratory of Fiber Modification and Functional Fiber, School of Materials Science and Chemical Engineering, Tianjin Polytechnic University, Tianjin 300160, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Xiao
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Rui-Feng
authors.initials: RF
authors.lastname: Xing
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Dong
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Rui
authors.initials: R
authors.lastname: Zhang
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D020100:Hydrogels / Q000737:chemistry*; D008422:Materials Testing; D013696:Temperature; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D020100:Hydrogels