title: Antihyperlipidemic compounds from the fruit of Piper longum L.
abstract: A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.
authors.affiliation: Institute of Macromolecular Chemistry and Mongolian Medicine, Inner Mongolia University, Huhhot 010021, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Jin
authors.forename: Gereltu
authors.initials: G
authors.lastname: Borjihan
authors.forename: Ruiguo
authors.initials: R
authors.lastname: Zhao
authors.forename: Zhaorigetu
authors.initials: Z
authors.lastname: Sun
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Uryu
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D052117:Benzodioxoles / Q000302:isolation & purification / Q000494:pharmacology*; D004148:Dioxolanes / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D010880:Piperidines / Q000302:isolation & purification / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000494:pharmacology; D010881:Piperidones
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D004148:Dioxolanes; D000960:Hypolipidemic Agents; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D019821:Simvastatin; C419151:pipernonaline; C498077:piperlongumine; D010881:Piperidones; C008922:piperine