title: Avoid delivering therapies for nonsustained fast ventricular tachyarrhythmia in patients with implantable cardioverter/defibrillator: the ADVANCE III Trial.
abstract: BACKGROUND
  The purpose of this investigation is to evaluate whether a prolonged detection interval for life threatening ventricular tachyarrhythmia (VT) is able to reduce therapies (Rx) delivered by an implantable cardioverter/defibrillator (ICD). Until now, only the PREPARE trial demonstrated a reduction of ICD Rx in a cohort of primary prevention patients.
  
  
  RESULTS
  The ADVANCE III study is a prospective, randomized, parallel trial with 2 arms evaluating different intervals to detect (NID), i.e., 18/24 (as currently used) versus 30/40. The primary endpoint is to demonstrate a 20% reduction of ICD Rx (antitachycardia pacing or shocks) delivered to terminate spontaneous VT with a cycle length < or =320 ms in patients with Class I-IIA indication for ICD therapy, regardless of cardiac resynchronization capabilities. The worldwide investigation started in spring 2008 and is expected to be finished in 2011.
  
  
  CONCLUSIONS
  The ADVANCE III trial is the first randomized investigation evaluating the reduction of ICD Rx for fast VT due to a prolongation of NID in a general ICD patient cohort.
authors.affiliation: Department of Medicine-Cardiology, University of Bonn, Sigmund-Freud-Strasse 25, Bonn, Germany. joerg.schwab@ukb.unibonn.de
authors.forename: Joerg O
authors.initials: JO
authors.lastname: Schwab
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gasparini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Lunati
authors.forename: Alessandro
authors.initials: A
authors.lastname: Proclemer
authors.forename: Bernd
authors.initials: B
authors.lastname: Kaup
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Santi
authors.forename: Guiseppe
authors.initials: G
authors.lastname: Ligorio
authors.forename: Catherine
authors.initials: C
authors.lastname: Klersy
authors.forename: João
authors.initials: J
authors.lastname: DE Sousa
authors.forename: Andrzej
authors.initials: A
authors.lastname: Okreglicki
authors.forename: Angel
authors.initials: A
authors.lastname: Arenal
authors.forename: Maurits
authors.initials: M
authors.lastname: Wijffels
authors.forename: Bernd
authors.initials: B
authors.lastname: Lemke
mesh_terms: D017147:Defibrillators, Implantable; D004554:Electric Countershock / Q000379:methods*; D006801:Humans; D012107:Research Design; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000517:prevention & control*; D016896:Treatment Outcome