title: Daptomycin versus Friulimicin B: in-depth profiling of Bacillus subtilis cell envelope stress responses.
abstract: The related lipo(depsi)peptide antibiotics daptomycin and friulimicin B show great potential in the treatment of multiply resistant gram-positive pathogens. Applying genome-wide in-depth expression profiling, we compared the respective stress responses of Bacillus subtilis. Both antibiotics target envelope integrity, based on the strong induction of extracytoplasmic function sigma factor-dependent gene expression. The cell envelope stress-sensing two-component system LiaRS is exclusively and strongly induced by daptomycin, indicative of different mechanisms of action in the two compounds.
authors.affiliation: KIT Research Group 11-1, Karlsruhe Institute of Technology, Karlsruhe, Germany.
authors.forename: Tina
authors.initials: T
authors.lastname: Wecke
authors.forename: Daniela
authors.initials: D
authors.lastname: Zühlke
authors.forename: Ulrike
authors.initials: U
authors.lastname: Mäder
authors.forename: Sina
authors.initials: S
authors.lastname: Jordan
authors.forename: Birgit
authors.initials: B
authors.lastname: Voigt
authors.forename: Stefan
authors.initials: S
authors.lastname: Pelzer
authors.forename: Harald
authors.initials: H
authors.lastname: Labischinski
authors.forename: Georg
authors.initials: G
authors.lastname: Homuth
authors.forename: Michael
authors.initials: M
authors.lastname: Hecker
authors.forename: Thorsten
authors.initials: T
authors.lastname: Mascher
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects* / Q000235:genetics; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D017576:Daptomycin / Q000494:pharmacology*; D020869:Gene Expression Profiling; D010455:Peptides / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D010455:Peptides; C416818:friulimicin B; D017576:Daptomycin