CAG repeat polymorphism of the MEF2A gene is not associated with the risk of coronary artery disease among Taiwanese.
A 21-bp deletion mutation of the exon 11 of the myocyte enhancer factor-2A (MEF2A) gene was shown to cause familial coronary artery disease. This finding raises the possibility that MEF2A variants may contribute to the risk of coronary artery disease. In total, 258 patients with coronary artery disease and 258 controls were analyzed for the MEF2A variants. The analysis revealed that all patients were negative for Pro279Leu and 21-bp deletion mutations in exons 7 and 11, respectively. The distribution of the allele frequencies of MEF2A exon 11 CAG repeat (CAG)n polymorphism was similar in both patients and controls; Further, no significant association was noted between MEF2A exon 11 (CAG)n polymorphism and the risk of myocardial infarction. Our data suggest that there is no evidence of an association between the MEF2A exon 11 (CAG)n polymorphism and the risk of coronary artery disease/myocardial infarction in the Chinese population in Taiwan.
Hsu
Lung-An
LA
First Cardiovascular Division, Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Taiwan.
Chang
Chi-Jen
CJ
Teng
Ming-Sheng
MS
Semon Wu
Hu
Chiao-Feng
CF
Chang
Wen-Ya
WY
Ko
Yu-Lin
YL
D000368:Aged; D002681:China / Q000208:ethnology; D015897:Comorbidity; D003327:Coronary Disease / Q000208:ethnology / Q000235:genetics*; D004252:DNA Mutational Analysis; D005006:Ethnicity / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D026161:MADS Domain Proteins / Q000235:genetics* / Q000502:physiology; D064326:MEF2 Transcription Factors; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009203:Myocardial Infarction / Q000208:ethnology / Q000235:genetics; D018006:Myogenic Regulatory Factors / Q000235:genetics* / Q000502:physiology; D012306:Risk; D012307:Risk Factors; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D013624:Taiwan / Q000453:epidemiology; D018911:Trinucleotide Repeats
D026161:MADS Domain Proteins; D064326:MEF2 Transcription Factors; C578035:MEF2A protein, human; D018006:Myogenic Regulatory Factors