title: Development of a simple low noise amplifier for recording of sensory mass signals from peripheral nerves.
abstract: In the present work, a simple low noise amplifier system with relatively few components for the recording of peripheral nerve signals via electrodes, such as cuff electrodes, was developed. The amplifier system was developed with the aid of a computer-aided characterization tool, which allowed the characterization of bioelectric signal amplifiers and the identification of system parameters. Three commercially available amplifier systems were investigated with this tool regarding their technical parameters. In addition, peripheral sensory nerve mass signals were analyzed to validate the target specifications for the amplifier to be designed with regard to amplitude and frequency range. An amplifier was designed and developed according to these specifications, characterized in comparison to the commercial amplifiers, and successfully applied in pilot experiments on the sciatic nerve in a rat animal model.
authors.affiliation: Laboratory for Biomedical Microtechnology, Department of Microsystems Engineering-IMTEK, University of Freiburg, Freiburg, Germany. thomas.stieglitz@imtek.uni-freiburg.de
authors.forename: Thomas
authors.initials: T
authors.lastname: Stieglitz
authors.forename: Dominic
authors.initials: D
authors.lastname: Klausmann
authors.forename: Thilo B
authors.initials: TB
authors.lastname: Krueger
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D017076:Computer-Aided Design; D004568:Electrodiagnosis / Q000295:instrumentation*; D004581:Electronics / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D010525:Peripheral Nerves / Q000502:physiology; D051381:Rats; D015203:Reproducibility of Results; D012584:Sciatic Nerve / Q000502:physiology*; D012680:Sensitivity and Specificity; D014110:Touch / Q000502:physiology*