Exocyclic DNA adducts as biomarkers of lipid oxidation and predictors of disease. Challenges in developing sensitive and specific methods for clinical studies.
Exocyclic DNA adducts are emerging as potential new tools for the study of oxidative stress-related diseases as well as the determination of cancer etiology and cancer risk. It is important to determine whether levels of exocyclic DNA adducts reflect redox stress in vivo and what role these adducts play in human diseases. To answer these important questions, interindividual differences, tissue distribution, background levels, and repair have to be assessed. This review focuses on recent developments in the use of these adducts as possible biomarkers for disease risk related to oxidative stress and on the challenges in developing sensitive and specific methods for clinical studies.
Medeiros
Marisa H G
MH
Departamento de Bioquimica, Instituto de Quimica, Universidade de Sao Paulo, Av. Prof. Lineu Prestes 748, CEP 05508-900, Sao Paulo, Brazil. mhgdmede@iq.usp.br
D015415:Biomarkers / Q000652:urine; D018736:DNA Adducts / Q000032:analysis*; D003933:Diagnosis; D006147:Guanine / Q000031:analogs & derivatives; D006801:Humans; D007118:Immunoassay; D015227:Lipid Peroxidation / Q000235:genetics; D018384:Oxidative Stress; D010761:Phosphorus Radioisotopes
D015415:Biomarkers; D018736:DNA Adducts; D010761:Phosphorus Radioisotopes; D006147:Guanine