title: The Salmonella pathogenicity island 2-encoded type III secretion system is essential for the survival of Salmonella enterica serovar Typhimurium in free-living amoebae.
abstract: Free-living amoebae represent a potential reservoir and predator of Salmonella enterica. Through the use of type III secretion system (T3SS) mutants and analysis of transcription of selected T3SS genes, we demonstrated that the Salmonella pathogenicity island 2 is highly induced during S. enterica serovar Typhimurium infection of Acanthamoeba polyphaga and is essential for survival within amoebae.
authors.affiliation: National Centre for Zoonosis Research and Department of Veterinary Pathology, University of Liverpool, Leahurst Campus, Neston CH64 7TE, United Kingdom.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Bleasdale
authors.forename: Penelope J
authors.initials: PJ
authors.lastname: Lott
authors.forename: Aparna
authors.initials: A
authors.lastname: Jagannathan
authors.forename: Mark P
authors.initials: MP
authors.lastname: Stevens
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Birtles
authors.forename: Paul
authors.initials: P
authors.lastname: Wigley
mesh_terms: D000048:Acanthamoeba / Q000382:microbiology*; D000818:Animals; D020869:Gene Expression Profiling; D005798:Genes, Bacterial; D020043:Genes, Essential; D044404:Genomic Islands; D026901:Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*; D050296:Microbial Viability; D009154:Mutation; D012486:Salmonella typhimurium / Q000472:pathogenicity*; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D026901:Membrane Transport Proteins; D037521:Virulence Factors