title: Failure of gamma-aminobutyrate acid-beta agonist baclofen to improve balance, gait, and postural control after vestibular schwannoma resection.
abstract: BACKGROUND
  Incomplete postural control often occurs after vestibular schwannoma (VS) surgery. Customized vestibular rehabilitation in man improves and speeds up this process. Animal experiments have shown an improved and faster vestibular compensation after administration of the gamma-aminobutyrate acid (GABA)-beta agonist baclofen.
  
  
  OBJECTIVE
  To examine whether medical treatment with baclofen provides an improvement of the compensation process after VS surgery.
  
  
  METHODS
  A time-series study with historical control.
  
  
  METHODS
  Tertiary referral center.
  
  
  METHODS
  Thirteen patients who underwent VS resection were included and compared with a matched group of patients. In addition to an individualized vestibular rehabilitation protocol, the study group received medical treatment with 30 mg baclofen (a GABA-beta agonist) daily during the first 6 weeks after surgery.
  
  
  METHODS
  Clinical gait and balance tests (Romberg maneuver, standing on foam, tandem Romberg, single-leg stance, Timed Up & Go test, tandem gait, Dynamic Gait Index) and Dizziness Handicap Inventory. Follow-up until 24 weeks after surgery.
  
  
  RESULTS
  When examining the postoperative test results, the group treated with baclofen did not perform better when compared with the matched (historical control) group. Repeated-measures analysis of variance revealed no significant group effect, but a significant time effect for almost all balance tests during the acute recovery period was found. An interaction effect between time and intervention was seen concerning single-leg stance and Dizziness Handicap Inventory scores for the acute recovery period.
  
  
  CONCLUSIONS
  Medical therapy with baclofen did not seem to be beneficial in the process of central vestibular compensation.
authors.affiliation: Antwerp University Research centre for Equilibrium and Aerospace, University Department of Otorhinolaryngology and Head and Neck Surgery, Antwerp University Hospital, University of Antwerp, Belgium.
authors.forename: Claudia F J
authors.initials: CF
authors.lastname: De Valck
authors.forename: Luc
authors.initials: L
authors.lastname: Vereeck
authors.forename: Floris L
authors.initials: FL
authors.lastname: Wuyts
authors.forename: Paul H
authors.initials: PH
authors.lastname: Van de Heyning
mesh_terms: D000328:Adult; D001418:Baclofen / Q000494:pharmacology*; D004244:Dizziness / Q000188:drug therapy / Q000523:psychology; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology*; D058786:GABA-B Receptor Agonists; D005684:Gait / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000523:psychology / Q000534:rehabilitation / Q000601:surgery*; D004856:Postural Balance / Q000187:drug effects*; D011187:Posture / Q000502:physiology*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D015837:Vestibular Diseases / Q000523:psychology / Q000534:rehabilitation / Q000601:surgery*
chemical_list: D018755:GABA Agonists; D058786:GABA-B Receptor Agonists; D001418:Baclofen