title: A new chromosomal three-way rearrangement involving MLL masked by a t(9;19)(p11;p13) in an infant with acute myeloid leukemia.
abstract: Infants diagnosed with acute myelogenous leukemia (AML) are likely to have subtypes M4 or M5 characterized by 11q23 abnormalities like a t(9;11)(p22;q23). Detection of all possible types of chromosomal abnormalities, including mixed lineage leukemia (MLL) gene rearrangements at 11q23, is of importance for the identification of biological subgroups, which might differ in drug resistance and/or clinical outcome. Here, we report the clinical, conventional banding and molecular cytogenetics data of a 6-month-old boy with an AML-M5 presenting with a unique cryptic rearrangement involving the MLL gene: a three-way t(9;19;11)(p11.2;p13.1;q23).
authors.affiliation: Genetic Department of University Federal of Pernambuco, Av. Prof. Moraes Rego, 1235-Cidade Universitária, Recife-PE-CEP: 50670-901 Brasil. tjmsalles@uol.com.br
authors.forename: Terezinha
authors.initials: T
authors.lastname: de Jesus Marques-Salles
authors.forename: Thomas
authors.initials: T
authors.lastname: Liehr
authors.forename: Hasmik
authors.initials: H
authors.lastname: Mkrtchyan
authors.forename: Susana C
authors.initials: SC
authors.lastname: Raimondi
authors.forename: Mariana
authors.initials: M
authors.lastname: Tavares de Souza
authors.forename: Amanda Faria
authors.initials: AF
authors.lastname: de Figueiredo
authors.forename: Soraia
authors.initials: S
authors.lastname: Rouxinol
authors.forename: Fernanda C
authors.initials: FC
authors.lastname: Jordy Macedo
authors.forename: Eliana
authors.initials: E
authors.lastname: Abdelhay
authors.forename: Neide
authors.initials: N
authors.lastname: Santos
authors.forename: Maria Luiza
authors.initials: ML
authors.lastname: Macedo Silva
mesh_terms: D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
chemical_list: D051788:Myeloid-Lymphoid Leukemia Protein