title: Decreased circulatory erythropoietin in hyperacute phase of myocardial ischemia.
abstract: OBJECTIVE
  Erythropoietin provides cellular protection by inhibiting apoptosis. Myocardial damage related to the cardiac ischemia is more prominent especially in the first 6 h. In the present study, circulatory erythropoietin levels in response to cardiac ischemia were evaluated.
  
  
  METHODS
  Patients with stable angina who underwent balloon angioplasty (study group, n = 55) and hospitalized for coronary angiography (as control group, n = 23) were enrolled into the study. Serum erythropoietin levels were measured in both groups in baseline, 6 and 18 h after the procedure.
  
  
  RESULTS
  Coronary balloon inflation time was accepted as duration of myocardial ischemia. Study group showed significant erythropoietin reduction at sixth hour compared to control group. Erythropoietin reduction at sixth hour was significantly correlated with duration of myocardial ischemia.
  
  
  CONCLUSIONS
  Decreased circulatory erythropoietin levels in the early phase of acute cardiac ischemia may accelerate the apoptotic activity. Recombinant erythropoietin replacement to prevent erythropoietin decrease following cardiac ischemia may have negative effect on myocyte loss.
authors.forename: Emin
authors.initials: E
authors.lastname: Alioglu
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Ercan
authors.forename: Gulden
authors.initials: G
authors.lastname: Sonmez Tamer
authors.forename: Can
authors.initials: C
authors.lastname: Duman
authors.forename: Ugur
authors.initials: U
authors.lastname: Turk
authors.forename: Istemihan
authors.initials: I
authors.lastname: Tengiz
authors.forename: Nurullah
authors.initials: N
authors.lastname: Tuzun
authors.forename: Serkan
authors.initials: S
authors.lastname: Saygi
mesh_terms: D000208:Acute Disease; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*
chemical_list: D004921:Erythropoietin