[Effect of pectins of different degree of esterification on in-vitro sophoridine release of hydrophilic matrix tablets containing total alkaloids of Sophora alopecuroides].
OBJECTIVE
To prepare colon-targetting tablets of total alkaloids of Sophora alopecuroides and evaluate the effect of pectins of different degree of esterification (DE) on sophoridine release profiles in-vitro.


METHODS
Wet granulation technique was employed to prepare petin-based matrix tablets, then tablets were coated the optimal formulation with Kollicoat MAE 30 DP based on the optimal formulation and analysed their release.


RESULTS
Coated formulation E could target total alkaloids of S. alopecuroides to colon and various DE of pectin exerted different effects on sophoridine release. The release of low DE pectin-based matrix tablets coating with Kollicoat MAE 30 DP approximatedly fitted zere-order eqution, which was erosion depended.


CONCLUSIONS
Low DE pectin-based matrix tablet coating with Kollicoat MAE 30 DP can deliver sophoridine to colon, hence improve the effectiveness of sophoridine.
Zhao
Wen-Chang
WC
School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China.
Deng
Hong-Zhu
HZ
Song
Li-Jun
LJ
Huang
Yong-Heng
YH
Huang
De-Hao
DH
Yan
Hui
H
D000470:Alkaloids / Q000737:chemistry*; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003106:Colon / Q000737:chemistry; D004951:Esterification; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008297:Male; D010368:Pectins / Q000737:chemistry*; D011807:Quinolizines / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D029909:Sophora / Q000737:chemistry*; D013607:Tablets / Q000737:chemistry*; D000093842:Matrines
D000470:Alkaloids; D011807:Quinolizines; D013607:Tablets; D010368:Pectins; D000093842:Matrines