Non-alcoholic steatohepatitis: an overview.
Non-alcoholic fatty liver disease (NAFLD) includes a broad spectrum of fat-induced liver injury, ranging from mild steatosis to cirrhosis and liver failure. The presence of obesity and insulin resistance is strongly associated with non-alcoholic fatty liver and a greater risk of advanced disease. We present here a review of the mechanisms involved in the pathogenesis of NAFLD, advances in the diagnosis, and options for treatment.
Shifflet
Allison
A
Division of Gastroenterology-Hepatology, Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut, USA.
Wu
George Y
GY
D015897:Comorbidity; D005234:Fatty Liver / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D006505:Hepatitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications / Q000175:diagnosis; D009765:Obesity / Q000150:complications / Q000175:diagnosis; D015995:Prevalence; D012307:Risk Factors