title: Central corneal thickness and its associations with ocular and systemic factors: the Singapore Malay Eye Study.
abstract: OBJECTIVE
  To examine the association between central corneal thickness (CCT) and potential systemic and ocular factors affecting CCT in an Asian population.
  
  
  METHODS
  Population-based cross-sectional study.
  
  
  METHODS
  A total of 3,280 (78.7% response) adults aged 40 to 80 years of Malay ethnicity living in Singapore underwent a standardized interview and ocular and systemic examination at a centralized study clinic. CCT was measured with an ultrasound pachymeter. Blood samples were obtained to determine serum glucose, cholesterol, and triglyceride levels, and urine samples to determine glomerular filtration rate. The presence of diabetes, hypertension, chronic kidney disease (CKD), and metabolic syndrome were defined based on a combination of investigation results and participant's history.
  
  
  RESULTS
  CCT was obtained from 3,239 individuals. CCT was normally distributed with a mean of 541.2 microm in the right eye. While controlling for age and gender, CCT was greater in individuals with higher body mass index (BMI) (P = .038), greater intraocular pressure (IOP) (P < .001), greater axial length (P = .005), and greater radius of corneal curvature (P < .001). Individuals with CKD (P = 0.012) and metabolic syndrome (P < .001) also had greater CCT.
  
  
  CONCLUSIONS
  CCT is associated with higher IOP, longer axial length, and greater radius of corneal curvature, as well as higher BMI, metabolic syndrome, and CKD.
authors.affiliation: Singapore National Eye Centre & Singapore Eye Research Institute, Singapore.
authors.forename: Daniel H W
authors.initials: DH
authors.lastname: Su
authors.forename: Tien Y
authors.initials: TY
authors.lastname: Wong
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Foster
authors.forename: Wan-Ting
authors.initials: WT
authors.lastname: Tay
authors.forename: Seang-Mei
authors.initials: SM
authors.lastname: Saw
authors.forename: Tin
authors.initials: T
authors.lastname: Aung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000208:ethnology; D001786:Blood Glucose / Q000032:analysis*; D001794:Blood Pressure; D001824:Body Constitution; D003315:Cornea / Q000000981:diagnostic imaging / Q000473:pathology*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D005901:Glaucoma / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000175:diagnosis / Q000208:ethnology; D007429:Intraocular Pressure; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis* / Q000208:ethnology; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000175:diagnosis / Q000208:ethnology; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000175:diagnosis / Q000235:genetics; D012307:Risk Factors; D012846:Singapore / Q000453:epidemiology; D014463:Ultrasonography
chemical_list: D001786:Blood Glucose; D008055:Lipids