title: Insular cortex lesions and morphine-induced suppression of conditioned stimulus intake in the rat.
abstract: The present experiment examined the influence of insular cortex (IC) lesions on the intake of a taste stimulus in a consummatory procedure that used morphine as the unconditioned stimulus. In normal rats, morphine caused a rapid reduction in saccharin intake when the taste was novel but not when it was familiar. Irrespective of stimulus novelty, morphine had little influence on the saccharin consumption of IC-lesioned rats. The results are discussed in terms of a lesion-induced disruption of (i) a reward comparison mechanism and (ii) the perception of taste novelty.
authors.affiliation: Department of Psychology, University of Illinois at Chicago, Chicago, IL 60607, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Roman
authors.forename: Steve
authors.initials: S
authors.lastname: Reilly
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects / Q000293:injuries* / Q000502:physiology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004435:Eating / Q000187:drug effects*; D018690:Excitatory Amino Acid Agonists / Q000633:toxicity; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D016202:N-Methylaspartate / Q000633:toxicity; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D012439:Saccharin / Q000008:administration & dosage; D013549:Sweetening Agents / Q000008:administration & dosage; D013649:Taste / Q000187:drug effects
chemical_list: D018690:Excitatory Amino Acid Agonists; D009294:Narcotics; D013549:Sweetening Agents; D016202:N-Methylaspartate; D009020:Morphine; D012439:Saccharin