title: Nataxazole, a new benzoxazole derivative with antitumor activity produced by Streptomyces sp. Tü 6176.
abstract: The new benzoxazole derivative nataxazole was isolated from Streptomyces sp. (strain Tü 6176). Nataxazole is related in structure to the potent antitumor compounds UK-1 and AJI9561 and showed similar strong growth inhibitory activity against various human tumor cell lines.
authors.affiliation: Centro de Biociencias, Universidade Federal do Rio Grande do Norte, Natal, Brasil.
authors.forename: Patricia S M
authors.initials: PS
authors.lastname: Sommer
authors.forename: Rosemary C
authors.initials: RC
authors.lastname: Almeida
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schneider
authors.forename: Winfried
authors.initials: W
authors.lastname: Beil
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001583:Benzoxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D001583:Benzoxazoles; C540755:nataxazole