title: Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles.
abstract: The first examples of thiazolo[4,5-e]benzoisoxazoles are obtained from bromination of dihydrobenzo[d]isoxazol-4(5H)-one followed by cyclocondensation with thiourea, in the presence of DDQ. Analogously, cyclocondensation with thioamides provided 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. A 55-member library of these heterocycles is reported.
authors.affiliation: Department of Chemistry, One Shields Avenue, University of California, Davis, California 95616, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: El-Badri
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Kurth
mesh_terms: D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D054879:Halogenation; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001555:Benzene Derivatives; D007555:Isoxazoles; D013844:Thiazoles