title: Clinicopathological significance of cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia.
abstract: Lobular endocervical glandular hyperplasia (LEGH) is usually assumed to be a benign tumor-like lesion of the glands of the uterine cervix. However, LEGH has been associated with obvious cervical adenocarcinoma. The clinicopathological significance of coexistence of LEGH with adenocarcinoma remains unclear. We microscopically examined the presence or absence of LEGH components in 95 stage Ib cervical adenocarcinomas. Gastric mucin was detected with the use of clone HIK1083. Associations of the coexistence of LEGH components with clinicopathological variables were analyzed. LEGH components were present in 16 cases (16.8%). Gastric mucin was positive in all 16 LEGH components, as compared with only 6 of the 95 adenocarcinoma components. Of the 16 adenocarcinomas with LEGH components, 15 were well-differentiated mucinous adenocarcinomas, and one was poorly differentiated adenocarcinoma. The mortality rate of tumor recurrence was 25% (4 of 16) in patients whose tumors had LEGH components, and 21.5% (17 of 79) in those whose tumors had no LEGH components. There was no significant difference in survival. Early cervical adenocarcinoma was relatively frequently associated with LEGH components. LEGH may be one of the factors related to the development of cervical adenocarcinoma, but adenocarcinoma with LEGH components does not necessarily develop into a highly aggressive "adenoma malignum."
authors.affiliation: Department of Basic Pathology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. shinshin@med.kurume-u.ac.jp
authors.forename: Shin
authors.initials: S
authors.lastname: Nishio
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tsuda
authors.forename: Naoki
authors.initials: N
authors.lastname: Fujiyoshi
authors.forename: Shun-Ichiro
authors.initials: S
authors.lastname: Ota
authors.forename: Kimio
authors.initials: K
authors.lastname: Ushijima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sasajima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kasamatsu
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsubara
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000378:metabolism / Q000473:pathology*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000378:metabolism; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000150:complications / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16