title: Regulatory role of G protein-coupled estrogen receptor for vascular function and obesity.
abstract: We found that the selective stimulation of the intracellular, transmembrane G protein-coupled estrogen receptor (GPER), also known as GPR30, acutely lowers blood pressure after infusion in normotensive rats and dilates both rodent and human arterial blood vessels. Stimulation of GPER blocks vasoconstrictor-induced changes in intracellular calcium concentrations and vascular tone, as well as serum-stimulated cell proliferation of human vascular smooth muscle cells. Deletion of the GPER gene in mice abrogates vascular effects of GPER activation and is associated with visceral obesity. These findings suggest novel roles for GPER in protecting from cardiovascular disease and obesity.
authors.affiliation: Departement für Innere Medizin, Klinik und Poliklinik für Innere Medizin, Universitätsspital Zürich, Rämistrasse 100, CH-8091 Zürich, Switzerland.
authors.forename: Elvira
authors.initials: E
authors.lastname: Haas
authors.forename: Indranil
authors.initials: I
authors.lastname: Bhattacharya
authors.forename: Eugen
authors.initials: E
authors.lastname: Brailoiu
authors.forename: Marlen
authors.initials: M
authors.lastname: Damjanović
authors.forename: G Cristina
authors.initials: GC
authors.lastname: Brailoiu
authors.forename: Xin
authors.initials: X
authors.lastname: Gao
authors.forename: Laurence
authors.initials: L
authors.lastname: Mueller-Guerre
authors.forename: Nicole A
authors.initials: NA
authors.lastname: Marjon
authors.forename: André
authors.initials: A
authors.lastname: Gut
authors.forename: Roberta
authors.initials: R
authors.lastname: Minotti
authors.forename: Matthias R
authors.initials: MR
authors.lastname: Meyer
authors.forename: Kerstin
authors.initials: K
authors.lastname: Amann
authors.forename: Emerita
authors.initials: E
authors.lastname: Ammann
authors.forename: Ana
authors.initials: A
authors.lastname: Perez-Dominguez
authors.forename: Michele
authors.initials: M
authors.lastname: Genoni
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Clegg
authors.forename: Nae J
authors.initials: NJ
authors.lastname: Dun
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Resta
authors.forename: Eric R
authors.initials: ER
authors.lastname: Prossnitz
authors.forename: Matthias
authors.initials: M
authors.lastname: Barton
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008323:Mammary Arteries / Q000187:drug effects; D051379:Mice; D008817:Mice, Mutant Strains; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D014664:Vasodilation / Q000187:drug effects
chemical_list: C109584:GPER1 protein, human; C532507:GPER1 protein, mouse; C520305:Gper1 protein, rat; D011960:Receptors, Estrogen; D043562:Receptors, G-Protein-Coupled; D004958:Estradiol