title: Screening for celiac disease in patients with osteoporosis.
abstract: OBJECTIVE
  Whether patients with osteoporosis should be screened for celiac disease is controversial. The objective of this study was to measure the prevalence of asymptomatic celiac disease in a cohort of patients with osteoporosis.
  
  
  METHODS
  We studied 140 patients (133 postmenopausal women and 7 men) aged 40-75 years (mean age, 62.9+/-9.4 years) with primary osteoporosis diagnosed by absorptiometry (spine or hip T-score <-2.5SD). We routinely measured serum and urinary calcium, serum phosphate, alkaline phosphatase, 25-OH-vitamin D3, and IgG and IgA antigliadin antibodies. Patients with positive antigliadin antibody tests were tested for antitransglutaminase antibodies.
  
  
  RESULTS
  A history of fractures were noted in 52 (37%) patients, with 57 peripheral and 54 vertebral fractures overall. Vitamin D deficiency was found in 60 (43%) patients. IgG antigliadin antibodies were positive in 11 (8%) patients, IgA antigliadin antibodies in 11 (8%) patients, and both antibodies in 4 (3%) patients. Antitransglutaminase antibodies were negative in all patients. No significant differences in laboratory test or absorptiometry results were found between patients with versus without IgA antigliadin antibodies. The T-score at the spine was nonsignificantly lower in patients with than without IgG antigliadin antibodies (-3.17+/-0.49 and -2.82+/-0.77, P=0.076).
  
  
  CONCLUSIONS
  We found no excess risk of celiac disease in our cohort of patients with osteoporosis. Despite the small sample size, our results cast doubt on the need for celiac-disease screening in osteoporotic patients who have no gastrointestinal symptoms.
authors.affiliation: University of Rhumatology Lille II, 59045 Lille Cedex. i-legroux@chru-lille.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Legroux-Gérot
authors.forename: Olivier
authors.initials: O
authors.lastname: Leloire
authors.forename: Franck
authors.initials: F
authors.lastname: Blanckaert
authors.forename: François
authors.initials: F
authors.lastname: Tonnel
authors.forename: Bruno
authors.initials: B
authors.lastname: Grardel
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Ducrocq
authors.forename: Bernard
authors.initials: B
authors.lastname: Cortet
mesh_terms: D000328:Adult; D000368:Aged; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000150:complications / Q000453:epidemiology*; D015331:Cohort Studies; D015897:Comorbidity; D005260:Female; D005602:France / Q000453:epidemiology; D005903:Gliadin / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000150:complications / Q000453:epidemiology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D007070:Immunoglobulin A; D005903:Gliadin