title: Perioperative administration of vedaprofen, tramadol or their combination does not interfere with platelet aggregation, bleeding time and biochemical variables in cats.
abstract: A randomized double blind and placebo controlled design was used to investigate the hemostatic, biochemical, gastrointestinal and behavioral effects of pre- and postoperative administration of vedaprofen 0.5mg/kg PO (V), tramadol 2mg/kg SC (T), their association (VT) or placebo (P) in 40 adult female cats (3.0+/-0.32kg; 1.8+/-0.7 years) distributed in groups of 10. Platelet aggregation and bleeding time were measured before and 52h after ovariohysterectomy. Serum urea, creatinine, alanine aminotransferase, alkaline phosphatase and gamma-glutamyl transferase concentrations were measured before and 7 days postoperatively. The occurrence of vomiting, frequency and consistency of feces, and behavior were observed for 7 days postoperatively. Morphine (0.5mg/kg, IM) was used as rescue analgesic. Laboratory variables did not change. Vomiting was observed only after morphine administration. Mild euphoria was observed in T and VT. The perioperative use of vedaprofen and/or tramadol did not modify the hemostatic, biochemical and gastrointestinal function in cats.
authors.affiliation: Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University, Botucatu, São Paulo, Brazil.
authors.forename: Juliana T
authors.initials: JT
authors.lastname: Brondani
authors.forename: Stelio P L
authors.initials: SP
authors.lastname: Luna
authors.forename: Gracy C G
authors.initials: GC
authors.lastname: Marcello
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Padovani
mesh_terms: D000700:Analgesics / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D007044:Hysterectomy / Q000662:veterinary; D009281:Naphthalenes / Q000008:administration & dosage*; D010052:Ovariectomy / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D010974:Platelet Aggregation / Q000187:drug effects; D019106:Postoperative Hemorrhage / Q000517:prevention & control / Q000662:veterinary*; D011422:Propionates / Q000008:administration & dosage*; D014147:Tramadol / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D009281:Naphthalenes; D011422:Propionates; D014147:Tramadol; C121784:2-(4-cyclohexyl-1-naphthalenyl)propanoic acid