title: Kikuchi-Fujimoto disease.
abstract: Kikuchi-Fujimoto disease is characterized by fever and lymphadenopathy, usually localized in the cervical region. This disease principally affects young females. It can be confused with lymphoma, adenocarcinoma metastasis and tuberculosis. We report two cases of Kikuchi-Fujimoto disease. In the first case, a 28-year-old female had been treated for tuberculosis one year prior and presented with a clinical and histological profile compatible with Kikuchi-Fujimoto disease. The second patient, a 58-year-old female, initially received treatment for Wegener's granulomatosis and, subsequently, for tuberculosis. Histopathological examination followed by immunohistochemical analysis confirmed the diagnosis of Kikuchi-Fujimoto disease in both cases. After the definitive diagnosis had been made, both patients were treated symptomatically, and both presented clinical improvement within one month. Subsequently, the latter patient developed systemic lupus erythematosus.
authors.affiliation: Departamento de Medicina Interna, Faculdade de Medicina, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil. rxavier@terra.com.br
authors.forename: Rogério Gastal
authors.initials: RG
authors.lastname: Xavier
authors.forename: Denise Rossato
authors.initials: DR
authors.lastname: Silva
authors.forename: Mauro Waldemar
authors.initials: MW
authors.lastname: Keiserman
authors.forename: Maria Francisca Torres
authors.initials: MF
authors.lastname: Lopes
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications / Q000473:pathology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D008198:Lymph Nodes / Q000473:pathology*; D008875:Middle Aged; D009333:Neck; D014388:Tuberculosis, Lymph Node / Q000175:diagnosis