Acute non-oliguric kidney failure and cholestatic hepatitis induced by ibuprofen and acetaminophen: a case report.
The combined use of acetaminophen with ibuprofen has long been in clinical use because the target of action of each drug is different and they do not interfere with each other. Appropriate dosing and managing of these drugs do not likely lead to organ toxicity. However, both acetaminophen and ibuprofen can induce liver problems and acute kidney failure, respectively, if administered at high doses. We report the case of a female child, in treatment with both acetaminophen and ibuprofen, administered at therapeutic antipyretic doses in condition of volume depletion, who suffered acute kidney and liver failure.


CONCLUSIONS
The combined ibuprofen and acetaminophen treatment, even if administered at therapeutic dosages and in a reduced number of doses, may be dangerous in conditions of volume depletion.
Zaffanello
Marco
M
Department of Mother-Child and Biology-Genetics, Section of Paediatrics, University of Verona, Verona, Italy. marco.zaffanello@univr.it
Brugnara
Milena
M
Angeli
Silvia
S
Cuzzolin
Laura
L
D000082:Acetaminophen / Q000009:adverse effects*; D058186:Acute Kidney Injury / Q000139:chemically induced*; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002675:Child, Preschool; D002779:Cholestasis / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005260:Female; D005334:Fever / Q000188:drug therapy; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*
D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D007052:Ibuprofen