[Current studies and prospective strategies in tissue-engineered trachea].
Over the past 10 years, much progress in the development of tracheal substitute by using tissue engineering techniques has been made. Nevertheless, some issues such as optimal extracellular matrix, cell culturing and seeding, epithelial regeneration, and revascularization remain the most stimulating challenges in tissue engineering science. It is stated that new study strategies and approaches should be explored to tackle these key problems in the near future. Here we present a review in the attempts to summarize the current advances in tissue-engineered trachea, and to look forward the prospects.
Shi
Hongcan
H
Department of Thoracic and Cardiovascular Surgery, College of Medicine, Yangzhou University, Yangzihou 225001, China.
Xu
Zhifei
Z
D001705:Bioprosthesis; D006801:Humans; D018919:Neovascularization, Physiologic; D023822:Tissue Engineering / Q000639:trends*; D054457:Tissue Scaffolds; D014132:Trachea / Q000098:blood supply / Q000601:surgery