Antihyperlipidemic compounds from the fruit of Piper longum L.
A bioassay-guided isolation of an ethanol extract of the fruit of Piper longum L. yielded piperlonguminine, piperine and pipernonaline, as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which is comparable to that of the commercial antihyperlipidemic drug, simvastatin.
Jin
Zhuang
Z
Institute of Macromolecular Chemistry and Mongolian Medicine, Inner Mongolia University, Huhhot 010021, China.
Borjihan
Gereltu
G
Zhao
Ruiguo
R
Sun
Zhaorigetu
Z
Hammond
Gerald B
GB
Uryu
Toshiyuki
T
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D052117:Benzodioxoles / Q000302:isolation & purification / Q000494:pharmacology*; D004148:Dioxolanes / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D000960:Hypolipidemic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D010880:Piperidines / Q000302:isolation & purification / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000494:pharmacology; D010881:Piperidones
D000470:Alkaloids; D052117:Benzodioxoles; D004148:Dioxolanes; D000960:Hypolipidemic Agents; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D019821:Simvastatin; C419151:pipernonaline; C498077:piperlongumine; D010881:Piperidones; C008922:piperine