title: Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin.
abstract: Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi. Glabridin also showed resistance modifying activity against drug resistant mutants of Candida albicans at a minimum inhibitory concentration of 31.25-250 microg/mL. Although the compound was reported earlier to be active against Candida albicans, but this is the first report of its activity against drug resistant mutants.
authors.affiliation: Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Kukrail Picnic Spot Road, P. O. CIMAP, Lucknow 226015, India.
authors.forename: Atiya
authors.initials: A
authors.lastname: Fatima
authors.forename: Vivek K
authors.initials: VK
authors.lastname: Gupta
authors.forename: Suaib
authors.initials: S
authors.lastname: Luqman
authors.forename: Arvind S
authors.initials: AS
authors.lastname: Negi
authors.forename: J K
authors.initials: JK
authors.lastname: Kumar
authors.forename: Karuna
authors.initials: K
authors.lastname: Shanker
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Saikia
authors.forename: Suchita
authors.initials: S
authors.lastname: Srivastava
authors.forename: M P
authors.initials: MP
authors.lastname: Darokar
authors.forename: Suman P S
authors.initials: SP
authors.lastname: Khanuja
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D006035:Glycyrrhiza / Q000737:chemistry*; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; C107601:glabridin