title: Spontaneous severe ovarian hyperstimulation syndrome in successive pregnancies with successful outcomes.
abstract: BACKGROUND
  Ovarian hyperstimulation syndrome is a known complication of ovarian stimulation, particularly with injectable gonadotropins. Spontaneous ovarian hyperstimulation is rare and often involves a conformational change in the follicle-stimulating hormone receptor, increasing its binding with human chorionic gonadotropin or thyroid-stimulating hormone. Few data are available regarding the management or outcomes of spontaneous ovarian hyperstimulation syndrome.
  
  
  METHODS
  A 23-year-old white female without history of infertility treatment presented with ovarian hyperstimulation syndrome in two pregnancies. The patient was treated by paracentesis catheter placement and albumin replacement. She had regression of symptoms between 11 weeks and 12 weeks of gestation in both pregnancies and delivered healthy term infants.
  
  
  CONCLUSIONS
  The case presented involves a patient with spontaneous severe ovarian hyperstimulation syndrome in two successive pregnancies. The patient was managed aggressively with paracentesis and albumin replacement resulting in two successful pregnancies.
authors.affiliation: From the Division of Maternal Fetal Medicine, Nebraska Medical Center; and Heartland Center for Reproductive Medicine, Omaha, Nebraska.
authors.forename: Todd R
authors.initials: TR
authors.lastname: Lovgren
authors.forename: Paul G
authors.initials: PG
authors.lastname: Tomich
authors.forename: Carl V
authors.initials: CV
authors.lastname: Smith
authors.forename: Teresa G
authors.initials: TG
authors.lastname: Berg
authors.forename: Victoria
authors.initials: V
authors.lastname: Maclin
mesh_terms: D001201:Ascites / Q000209:etiology* / Q000628:therapy; D003102:Colloids / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications* / Q000628:therapy*; D019152:Paracentesis; D011247:Pregnancy; D012709:Serum Albumin / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D003102:Colloids; D012709:Serum Albumin