Liquid nitrogen cryotherapy of lip mucosa hemangiomas under inhalation general anesthesia with sevoflurane in early infancy.
Mucous membrane hemangiomas of the lip are common benign vascular tumors of infancy. This clinical study evaluated the efficacy and safety of liquid nitrogen cryotherapy of mucous membrane hemangiomas of the lip in early infancy. It was a retrospective review of 127 pediatric patients with hemangiomas involving the lips who underwent liquid nitrogen cryotherapy under inhalation general anesthesia with sevoflurane. Forty-one males and 86 females were treated. The overall median age at diagnosis of the mucous membrane hemangiomas was 3.6 months (range, 7 days to 18 months). The oral mucous membrane hemangioma involved the vermilion of the lower lip in 78 cases (61.4%), the vermilion of the upper lip in 40 cases (31.5%), and both vermilions in 9 cases (7.1%). No complications because of anesthesia occurred. The mean follow-up was 10 months, with a range of 8 to 14 months; 94 lesions (74.0%) were completely involuted, 22 lesions (17.3%) were mostly involuted, 11 lesions (8.7%) were partially involuted, and no lesion showed a small amount of involution. Liquid nitrogen cryotherapy is an effective, simple, and safe treatment for mucous membrane hemangiomas of the lip in early infancy.
Chen
Wei-liang
WL
Department of Oral and Maxillofacial Surgery, the second Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China. drchen@vip.136.com
Zhang
Bin
B
Li
Jin-song
JS
Yang
Zhao-hui
ZH
Wang
Yong-jie
YJ
Huang
Zhi-quan
ZQ
Ye
Yu-shan
YS
D000769:Anesthesia, Inhalation; D018685:Anesthetics, Inhalation / Q000008:administration & dosage*; D017679:Cryotherapy / Q000379:methods*; D005260:Female; D006391:Hemangioma / Q000601:surgery*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008048:Lip Neoplasms / Q000601:surgery*; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage*; D009061:Mouth Mucosa; D009584:Nitrogen; D012189:Retrospective Studies; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D009584:Nitrogen