[Efficacy of memantine in Parkinson's disease with dementia].
Memantine (M) was used in the treatment of patients with Parkinson's disease (PD) with dementia. The drug was prescribed to 15 patients at first in a single dosage of 5 mg daily for one week, then the dosage was increased to 10 mg daily (one week), after to 15 mg daily (one week) and from the 4th week - to 20mg daily. Patients of the control group did not receive the drug. Efficacy and safety of M were assessed clinically and with a battery of widespread scales (UPDRS, MMSE, CGI etc), neuropsychological tests and the quality of life scale (PDQ-8). The study showed the ability of M to cause a stable improvement of mental state and its good tolerability. The efficacy of M in the cases studied was comparable with that in Alzheimer's disease.
Levin
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Batukaeva
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D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage*; D003704:Dementia / Q000150:complications*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008559:Memantine / Q000008:administration & dosage*; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D011788:Quality of Life; D016896:Treatment Outcome
D000978:Antiparkinson Agents; D008559:Memantine