title: Expression and significance of FRA-1 in non-small-cell lung cancer.
abstract: Fra-1 is thought to play an important role in tumorigenesis and progression. This study aimed to investigate the expression and significance of Fra-1 in non-small-cell lung cancer (NSCLC). By analyzing with Western blot and immunohistochemistry, we found that Fra-1 is downregulated in NSCLC, compared with normal bronchial epithelium. Further, the low expression of Fra-1 correlates with advanced tumor stage and poor survival. Meanwhile, the distinct cytoplasmic location of Fra-1 was found in almost all immunoreactive cells. These findings reveal a potential nontranscriptional function of Fra-1, and indicate that Fra-1 might play a role in the progression and prognosis of NSCLC.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Ma
authors.forename: Dong
authors.initials: D
authors.lastname: Chang
authors.forename: Min
authors.initials: M
authors.lastname: Gong
authors.forename: Fang
authors.initials: F
authors.lastname: Ding
authors.forename: Aiping
authors.initials: A
authors.lastname: Luo
authors.forename: Feng
authors.initials: F
authors.lastname: Tian
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Liu
authors.forename: Tianyou
authors.initials: T
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015153:Blotting, Western; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis* / Q000502:physiology; D046888:Tissue Array Analysis; D000099169:Fos-Related Antigen 1
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D000099169:Fos-Related Antigen 1