Great expectations for PIP: phosphoinositides as regulators of signaling during development and disease.
Phosphoinositides function as signaling precursors as well as regulators and scaffolds of signaling molecules required for important cellular processes such as membrane trafficking. Although a picture of the biochemical and cell biological functions of phosphoinositides is emerging, less is known about how these functions impact signaling on a broader scale during development. This review summarizes recent work on the role of phosphoinositides in developmental signaling and in a number of diseases and developmental disorders.
Skwarek
Lara C
LC
The Hospital for Sick Children, Program in Developmental and Stem Cell Biology, ON, Canada.
Boulianne
Gabrielle L
GL
D000818:Animals; D001756:Blastoderm / Q000502:physiology; D019521:Body Patterning / Q000502:physiology; D002455:Cell Division; D016764:Cell Polarity; D004705:Endocytosis / Q000502:physiology; D054262:Gastrulation / Q000502:physiology; D006801:Humans; D015394:Molecular Structure; D009024:Morphogenesis / Q000502:physiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010716:Phosphatidylinositols / Q000737:chemistry / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D063245:Plant Development; D010937:Plant Growth Regulators / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D019869:Phosphatidylinositol 3-Kinases; D010716:Phosphatidylinositols; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010937:Plant Growth Regulators; D020794:Receptor Protein-Tyrosine Kinases; D051880:Receptors, Notch