Toxicogenomics: transcription profiling for toxicology assessment.
Toxicogenomics, the application of transcription profiling to toxicology, has been widely used for elucidating the molecular and cellular actions of chemicals and other environmental stressors on biological systems, predicting toxicity before any functional damages, and classification of known or new toxicants based on signatures of gene expression. The success of a toxicogenomics study depends upon close collaboration among experts in different fields, including a toxicologist or biologist, a bioinformatician, statistician, physician and, sometimes, mathematician. This review is focused on toxicogenomics studies, including transcription profiling technology, experimental design, significant gene extraction, toxicological results interpretation, potential pathway identification, database input and the applications of toxicogenomics in various fields of toxicological study.
Zhou
Tong
T
Center for Drug Safety Sciences, The Hamner Institutes for Health Sciences, University of North Carolina at Chapel Hill, Research Triangle Park, NC, USA. TZhou@thehamner.org
Chou
Jeff
J
Watkins
Paul B
PB
Kaufmann
William K
WK
D000818:Animals; D020869:Gene Expression Profiling / Q000379:methods*; D006801:Humans; D018570:Risk Assessment / Q000379:methods; D015398:Signal Transduction; D043922:Toxicogenetics / Q000379:methods*