title: Prospective evaluation of coagulation in critically ill neonatal foals.
abstract: BACKGROUND
  Coagulopathy is a potentially underrecognized complication of sepsis and septic shock in critically ill neonatal foals.
  
  
  OBJECTIVE
  Critically ill neonatal foals have abnormalities in coagulation that are associated with disease severity and outcome.
  
  
  METHODS
  Foals <72 hours old admitted to a neonatal intensive care unit.
  
  
  METHODS
  Prospective, observational study. Blood was collected at admission, 24, and 48 hours for platelet count, prothrombin time, activated partial thromboplastin time, antithrombin activity and concentrations of fibrin degradation products, and fibrinogen in plasma from all foals.
  
  
  RESULTS
  Sixty-three foals were enrolled and classified as Septic Shock (12), Septic (28), and Other (23). At least 1 abnormal value was found in 18/28 (64%) samples from the Septic Shock group, 66/85 (78%) from the Septic group, and 30/59 (51%) from the Other group (P= .01). Coagulopathy (3 or more abnormal values) was present in 7/28 (25%) samples in the Septic Shock group, 14/85 (16%) samples in the Septic group, and 3/59 (5%) samples in the Other group (P= .0028). Clinically detectable bleeding occurred in 8/12 (67%) Septic Shock cases, 11/28 (39%) Septic cases, and 3/23 (13%) Other cases (P= .009). Foals in Septic Shock were 12.7 times more likely to have clinical evidence of bleeding than those in the Other group (95% CI 2.3-70, P= .004). Treatment with fluids or plasma did not have a detectable effect on coagulation values.
  
  
  CONCLUSIONS
  Coagulopathy commonly occurs in critically ill neonatal foals, especially those with sepsis and septic shock.
authors.affiliation: Department of Clinical Studies, University of Pennsylvania, Philadelphia, PA, USA.
authors.forename: A I
authors.initials: AI
authors.lastname: Bentz
authors.forename: J E
authors.initials: JE
authors.lastname: Palmer
authors.forename: B L
authors.initials: BL
authors.lastname: Dallap
authors.forename: P A
authors.initials: PA
authors.lastname: Wilkins
authors.forename: R C
authors.initials: RC
authors.lastname: Boston
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001777:Blood Coagulation / Q000502:physiology*; D016638:Critical Illness; D005260:Female; D006470:Hemorrhage / Q000662:veterinary; D006734:Horse Diseases / Q000097:blood*; D006736:Horses; D008297:Male; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000097:blood / Q000662:veterinary; D012772:Shock, Septic / Q000097:blood / Q000662:veterinary