title: Diarrhea as a minor adverse effect due to oral polio vaccine.
abstract: Using the adverse events monitoring system of Japan, we observed diarrhea cases in approximately 10% of patients who received oral poliovirus vaccine (OPV). This study was conducted to investigate whether diarrhea among children aged 0 to 1 is caused by OPV or by other factors such contact at the doctor's office and/or with others outside the home. We conducted a survey of the health of children after regular health check-ups and after the administration of the OPV. The data from the health check-ups were used as a control for the OPV case group. We compared the first-OPV dose vaccination group as well as the second-OPV dose vaccination group to the health check-up group. For cases of diarrhea, the odds ratio of the OPV group to the health check-up group was 1.776. Our findings strongly suggest that post-OPV cases of mild diarrhea are closely related to the administration of the OPV.
authors.affiliation: National Institute of Infectious Diseases, Tokyo 162-8640, Japan. tammy@nih.go.jp
authors.forename: Tamie
authors.initials: T
authors.lastname: Sugawara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Ohsuka
authors.forename: Keiko
authors.initials: K
authors.lastname: Taya
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Yasui
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Wada
authors.forename: Masasi
authors.initials: M
authors.lastname: Sakano
authors.forename: Rie
authors.initials: R
authors.lastname: Koshida
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Fujii
authors.forename: Senko
authors.initials: S
authors.lastname: Shibata
authors.forename: Goutaro
authors.initials: G
authors.lastname: Hashimoto
authors.forename: Hiromi
authors.initials: H
authors.lastname: Utsumi
authors.forename: Masami
authors.initials: M
authors.lastname: Sumitomo
authors.forename: Michiyo
authors.initials: M
authors.lastname: Ishihara
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kondo
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Kumi
authors.initials: K
authors.lastname: Ueno
authors.forename: Kazuko
authors.initials: K
authors.lastname: Araki
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Okabe
mesh_terms: D016907:Adverse Drug Reaction Reporting Systems; D016022:Case-Control Studies; D002675:Child, Preschool; D003967:Diarrhea / Q000139:chemically induced* / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D015994:Incidence; D007223:Infant; D007564:Japan / Q000453:epidemiology; D008297:Male; D011055:Poliovirus Vaccine, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D011159:Population Surveillance; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires
chemical_list: D011055:Poliovirus Vaccine, Oral