Rapid prototyping of scaphoid and lunate bones.
In this study, a novel rapid prototyping technology was used to fabricate scaphoid and lunate bone prostheses, two carpal bones that are prone to avascular necrosis. Carpal prostheses were fabricated with an Envisiontec Perfactory SXGA stereolithography system using Envisiontec eShell 200 photocurable polymer. Fabrication was guided using 3-D models, which were generated using Mimics software (Materialise NV, Leuven, Belgium) from patient computer tomography data. The prostheses were fabricated in a layer-by-layer manner; approximately 50-microm thick layers were observed in the prostheses. Hardness and Young's modulus values of polymerized eShell 200 material were 93.8 +/- 7.25 MPa and 3050 +/- 90 MPa, respectively. The minimum compressive force required for fracture was 1360 N for the scaphoid prosthesis and 1248 N for the lunate prosthesis. Polymerized Envisiontec eShell material exhibited high human neonatal epidermal keratinocyte cell viability rate in an MTT assay. The results of this study indicate that small bone prostheses fabricated by stereolithography using eShell 200 polymer may have suitable geometry, mechanical properties, and cytocompatibility properties for in vivo use.
Gittard
Shaun D
SD
Joint Department of Biomedical Engineering, University of North Carolina/North Carolina State University, Raleigh, NC 27599-7575, USA.
Narayan
Roger J
RJ
Lusk
Jason
J
Morel
Pierre
P
Stockmans
Filip
F
Ramsey
Michael
M
Laverde
Claire
C
Phillips
Jack
J
Monteiro-Riviere
Nancy A
NA
Ovsianikov
Aleksandr
A
Chichkov
Boris N
BN
D000704:Analysis of Variance; D002470:Cell Survival; D019245:Compressive Strength; D017076:Computer-Aided Design; D055119:Elastic Modulus; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D012667:Lunate Bone / Q000033:anatomy & histology*; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry; D019736:Prostheses and Implants; D011474:Prosthesis Design / Q000379:methods*; D012117:Resins, Synthetic / Q000737:chemistry; D021361:Scaphoid Bone / Q000033:anatomy & histology*; D014057:Tomography, X-Ray Computed
D011108:Polymers; D012117:Resins, Synthetic