Lack of association between interleukin-1 alpha rs1800587 polymorphism and Alzheimer's disease in two Independent European samples.
Interleukin-1 (IL1) can contribute to pathophysiology of Alzheimer's disease (AD) by promoting deposition of amyloid-beta in the brain. The gene encoding IL1 alpha (IL1A) has a common polymorphism in its 5' regulatory region (rs1800587) with possible functional effects. IL1A T/T genotype has been associated with AD but the overall effect is modest and negative studies have been published. The aim of this study was to investigate the association of the IL1A rs1800587 polymorphism with AD in two independent case-control groups from Greece (Athens) and Italy (Faenza and Granarolo). Preliminary results from the ongoing sample (110 patients with sporadic AD and 130 nonpsychiatric controls) showed no association between IL1A variants and AD, however C/T heterozygotes had more severe depression in AD (Cornell Scale for Depression in Dementia) compared to other genotypes (F = 4.56, d.f = 1, p = 0.037) after controlling for age, illness duration and cognitive impairment (MMSE). Despite the small sample size and the possibility of a false negative finding, our preliminary data support the hypothesis the IL1A rs1800587 variants are not associated with AD. The effect of the IL1A on depressive symptomatology warrants further investigations, however the lack of a gene-dose relationship would suggest a false positive.
Serretti
Alessandro
A
Institute of Psychiatry, University of Bologna, Bologna, Italy. alessandro.serretti@unibo.it
Olgiati
Paolo
P
Politis
Antonis
A
Malitas
Petros
P
Albani
Diego
D
Dusi
Sabrina
S
Polito
Letizia
L
De Mauro
Stefania
S
Zisaki
Aikaterini
A
Piperi
Christina
C
Liappas
Ioannis
I
Stamouli
Evangelia
E
Mailis
Antonis
A
Atti
Anna Rita
AR
Morri
Monica
M
Ujkaj
Manjola
M
Batelli
Sara
S
Forloni
Gianluigi
G
Soldatos
Costantine R
CR
Papadimitriou
George N
GN
De Ronchi
Diana
D
Kalofoutis
Anastasios
A
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D004493:Education; D005260:Female; D005787:Gene Frequency; D006115:Greece / Q000453:epidemiology; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D007558:Italy / Q000453:epidemiology; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*
D001057:Apolipoproteins E; D053582:Interleukin-1alpha; D004247:DNA