Assessment of the toxicological interaction of sertraline with cholinesterase inhibiting insecticides in aquatic insects using the black fly, Simulium vittatum IS-7.
Sertraline is a selective serotonin reuptake inhibitor (SSRI) prescribed as an antidepressant. Although SSRIs are known to block serotonin reuptake sites on cell membranes, they also have been shown to inhibit acetylcholinesterase (AChE) activity. Thus, the interaction of these chemicals with other AChE inhibitors, namely, organophosphate and carbamate insecticides, is of interest. In addition, these insecticides have been shown to interact with serotonergic neuronal pathways creating questions as to how these chemicals might interact. In this study, the interactive effect of sertraline (SSRI) in binary combinations with carbaryl (carbamate insecticide) and diazinon (organophosphate insecticide) was assessed using a 48-h acute toxicity test with black fly larvae, Simulium vittatum IS-7. Results showed that observed mortality was bracketed by the independent action model and concentration addition model with the independent action model slightly underestimating mortality and the concentration addition model slightly overestimating mortality. Varying the concentration of the chemicals in the mixture did not indicate that sertraline was interacting with the insecticides to make them more toxic or vice versa. These results indicate that sertraline and the insecticides are likely eliciting toxicity at separate neuronal pathways since no interaction was observed.
Overmyer
Jay P
JP
Department of Entomology, University of Georgia, 413 Biological Sciences Building, Athens, Georgia 30602, USA. jay.overmyer@syngenta.com
Smith
Paul F
PF
Kellock
Kristen A
KA
Kwon
Jeong-Wook
JW
Armbrust
Kevin L
KL
D000818:Animals; D012721:Carbaryl / Q000008:administration & dosage / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D003976:Diazinon / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D007306:Insecticides / Q000008:administration & dosage / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D020280:Sertraline / Q000008:administration & dosage / Q000494:pharmacology*; D012843:Simuliidae / Q000187:drug effects*; D014867:Water / Q000737:chemistry
D012721:Carbaryl; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases; D003976:Diazinon; D007306:Insecticides; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D014867:Water