[Preparation of microparticles of SCF-CO2 extraction of Salvia miltiorrhiza by RESS].
OBJECTIVE
Application of rapid expansion of supercritical solution (RESS) in preparing micropaticles of SCF-CO2 extraction of Salvia miltiorrhiza.


METHODS
The mixture which was composed of beta-cyclodextrin and SCF-CO2 extraction of S. miltiorrhiza with proportion 8:1 by weight, was granulated by RESS. The characteristics of the resululting particles were studied by scanning electron microscopy (SEM) and the assay of salviol IIA in particles which was determinated by HPLC.


RESULTS
The resulting particles were jacinth and photomicrograph produced by SEM showed that the morphology were silkiness and rugosity globular, the size distribution between 2 and 80 microm, and the contents of salviol IIA was 0.54%.


CONCLUSIONS
The RESS method is applicable for preparing microparticles of SCF-CO2 extraction of S. miltiorrhiza and low operating temperature, simple processing, and no environmental pollution, and no residual solvent.
He
Shuai
S
Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China.
Lei
Zheng-Jie
ZJ
Huang
Dong-Yi
DY
Zhang
Zhong-Yi
ZY
D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D027561:Salvia miltiorrhiza / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D004365:Drugs, Chinese Herbal