title: Novel norhumulene and xeniaphyllane-derived terpenoids from a formosan soft coral Sinularia gibberosa.
abstract: A novel skeletal norhumulene (1) and six xeniaphyllane-derived compounds, including norditerpenoids (2, 3) and diterpenoids (4-7), were isolated from the EtOAc extract of the Formosan soft coral Sinularia gibberosa. Their structures were elucidated by spectroscopic analysis. In vitro cytotoxic evaluation of the above metabolites revealed that 2 and 4 showed weak cytotoxicity toward a few cancer cell lines.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: Shin-Pin
authors.initials: SP
authors.lastname: Chen
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Hsiao-Chien
authors.initials: HC
authors.lastname: Yeh
authors.forename: Atallah Fouad
authors.initials: AF
authors.lastname: Ahmed
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000032:analysis; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C042686:humulene; C022616:thiazolyl blue