Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians.
The association of cognitive impairment with abnormal levels of serum lipid/lipoprotein in the elderly, in whom there are differences between the old aged 65-84 years and the oldest old aged 85 years or above, has been confirmed by previous studies. However, there are no relevant data from a Chinese oldest old population. In the present study, we observed an association of cognitive impairment with abnormal levels of serum lipid/lipoprotein among very old people using a Chinese cohort aged 90-108 years. The population included 709 unrelated Chinese nonagenarians and centenarians (67.8% women, mean age 93.8 years). The mean score of cognitive function (measured with the 30-item Mini-Mental State Examination, MMSE) was 14.9 (SD 6.0). Comparing abnormal with normal levels of serum lipid/lipoprotein (including triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein), in both genders, the odds ratio of cognitive impairment was statistically insignificant. There were no significant differences in levels of lipid/lipoprotein between subjects with and without cognitive impairment. Pearson correlation showed that MMSE scores were not significantly correlated with levels of lipid/lipoprotein. In summary, we found that levels of serum lipid/lipoprotein were not directly correlated with cognitive impairment among Chinese nonagenarians and centenarians.
Huang
Chang-Quan
CQ
Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
Dong
Bi-Rong
BR
Wu
Hong-Mei
HM
Zhang
Yan-Ling
YL
Wu
Jin-Hui
JH
Lu
Zhen-Chan
ZC
Flaherty
Joseph H
JH
D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000097:blood* / Q000453:epidemiology / Q000523:psychology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009483:Neuropsychological Tests; D018570:Risk Assessment
D008055:Lipids; D008074:Lipoproteins