title: From sextant to GPS: twenty-five years of mapping the genome with ChIP.
abstract: Since its inception, ChIP technology has evolved immensely. Technological advances have improved its specificity and sensitivity, its scale has expanded to a genome-wide level, and its relative ease of use has made it a virtually ubiquitous tool. This year marks the 25th anniversary of the development of ChIP. In honor of this milestone, we briefly revisit its history, offer a review of recent articles employing ChIP on a genome-wide scale, and lay out our views for the future of ChIP.
authors.affiliation: School of Medicine, Yale University, New Haven, Connecticut 06510, USA.
authors.forename: David A
authors.initials: DA
authors.lastname: Wacker
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
mesh_terms: D002874:Chromosome Mapping; D020869:Gene Expression Profiling; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis