title: Assessment of serum enzymatic markers of cardiomyocytes injury in female dogs submitted to ketamine S(+), atropin and xylazine association.
abstract: OBJECTIVE
  To assessment of the aspartate aminotransferase (AST), creatine kinase (CK) and creatine kinase isoenzyme fraction MB (CK-MB) serum activity in female dogs anesthetized with ketamine S (+), atropine and xylazine in several associations.
  
  
  METHODS
  Twenty three healthy female dogs randomly distributed in four groups named as GI (n=6), GII (n=6), GIII (n=6) and GIV (n=5) were treated respectively with atropine and ketamine S(+) (0.04 mg/kg; 10 mg/kg); ketamine S(+) (10 mg/kg); atropine, xylazine and ketamine S(+) (0.04 mg/kg; 1.1 mg/kg; 10 mg/kg) and xylazine and ketamine S(+) (1.1 mg/kg; 10 mg/kg). AST, CK and CK-MB serum activity measurement before pre-medication (M0) and one, two, three, six, 12, 24, 36 hours after.
  
  
  RESULTS
  There was no significant change in AST, CK e CK-MB serum activity among groups. However, CK serum activity in relation to moments within the groups was increased in all groups over the time in spite of treatment, except GI. In relation to CK-MB activity, in the moments within the group, it was observed an increase compared to baseline in all groups.
  
  
  CONCLUSIONS
  Creatine kinase and creatine kinase fraction MB isoenzyme showed changes in their mean values remained higher than baseline for a longer time in GIII and GIV.
authors.affiliation: Animal Science Post-Graduation Program, Veterinary College, Federal University of Goias, Goias, Brazil. lgvarjao@yahoo.com.br
authors.forename: Leandro Guimarães
authors.initials: LG
authors.lastname: Franco
authors.forename: Maria Clorinda Soares
authors.initials: MC
authors.lastname: Fioravanti
authors.forename: Adilson Donizeti
authors.initials: AD
authors.lastname: Damasceno
authors.forename: Aline Cardoso
authors.initials: AC
authors.lastname: Borges
authors.forename: Lorena Karine
authors.initials: LK
authors.lastname: Soares
authors.forename: Rogério Elias
authors.initials: RE
authors.lastname: Rabelo
authors.forename: Luiz Antônio Franco da
authors.initials: LA
authors.lastname: Silva
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D052279:Creatine Kinase, MB Form / Q000097:blood; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007649:Ketamine / Q000494:pharmacology; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000201:enzymology; D011897:Random Allocation; D014991:Xylazine / Q000494:pharmacology
chemical_list: D000316:Adrenergic alpha-Agonists; D000778:Anesthetics, Dissociative; D015415:Biomarkers; D014991:Xylazine; D007649:Ketamine; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D052279:Creatine Kinase, MB Form