Antiinflammatory and lipoxygenase inhibitory compounds from Vitex agnus-castus.
Several secondary metabolites, artemetin (1), casticin (2), 3,3'-dihydroxy-5,6,7,4'-tetramethoxy flavon (3), penduletin (4), methyl 4-hydroxybenzoate (5), p-hydroxybenzoic acid (6), methyl 3,4-dihydroxybenzoate (7), 5-hydroxy-2-methoxybenzoic acid (8), vanillic acid (9) and 3,4-dihydroxybenzoic acid (10) were isolated from a folkloric medicinal plant, Vitex agnus-castus. The structures of compounds 1-10 were identified with the help of spectroscopic techniques. Compounds 3-10 were isolated for the first time from this plant. These compounds were screened for their antiinflammatory and lipoxygenase inhibitory activities. Compounds 6, 7 and 10 were found to have significant antiinflammatory activity in a cell-based contemporary assay, whereas compounds 1 and 2 exhibited a potent lipoxygenase inhibition.
Choudhary
M Iqbal
MI
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. hej@cyber.net.pk
Jalil
Saima
S
Nawaz
Sarfraz Ahmad
SA
Khan
Khalid Mohammed
KM
Tareen
Rasool Bakhsh
RB
D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D020950:Vitex / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D016859:Lipoxygenase Inhibitors; D010936:Plant Extracts