[The hydrophilicity and cell affinity of polylactic acid containg bionic function group of phosphorylcholine].
A series of novel biodegradable and bionic functional polymers, PLLA-PC-PLLA, were synthesized using L-lactide ring-opening polymerization by L-a-Glycerophosphorylcholine (PC) from nature source. The hydrophilicity of the polymers was investigated. The results made known that, as PC group was brought into the backbone of PLLA, PLLA-PC-PLLA gained much better hydrophilicity than did PLLA, and polar phosphatidylcholines probably transferred to the sample surface in aqueous environment. The relative growth ratios of ECV304 cells to the lixivium of all PLLA-PC-PLLA were higher than 84% in 5 d culture. The cells adhesion of ECV304 on the films of PLLA-PC-PLLA lagged as compared to that on PLLA, but they could proliferate and cover the films in total. The difference between PLLA-PC-PLLA and PLLA was due to the existence of PC group. Thus, PLLA-PC-PLLA, the same as PLLA, are not cytotoxic, and ECV304 can attach and proliferate on them. PLLA-PC-PLLA have potential applications in the fields of tissue engineering and drug delivery system.
Luo
Juan
J
College of Chemistry, Sichuan University, Chengdu, China.
Wang
Lijian
L
Chen
Yuanwei
Y
Luo
Xianglin
X
Chen
Nianchao
N
Wan
Changxiu
C
Zhang
Xiaohua
X
D002448:Cell Adhesion / Q000502:physiology; D004337:Drug Carriers; D042783:Endothelial Cells / Q000166:cytology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D019344:Lactic Acid / Q000737:chemistry* / Q000494:pharmacology; D010767:Phosphorylcholine / Q000737:chemistry / Q000494:pharmacology*; D011091:Polyesters; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D054457:Tissue Scaffolds; D014471:Umbilical Veins / Q000166:cytology
D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D010767:Phosphorylcholine; D019344:Lactic Acid; C033616:poly(lactide)