title: A new type of tripropeptin with anteiso-branched chain fatty acid from Lysobacter sp. BMK333-48F3.
abstract: Branched chain amino acids are often utilized as the precursors of many lipid-containing bacterial secondary metabolites. The effect of isoleucine on the composition of the mixture of cyclic lipopeptide antibiotics, tripropeptins from Lysobacter sp. BMK333-48F3 was evaluated. As expected, a novel tripropeptin analog with an anteiso-branched fatty acid was produced. The new compound, TPPaiC shows potent antibacterial activity against Gram-positive bacteria including MRSA and VRE. On the other hand, no increase was observed in the production of other tripropeptins by the addition of isoleucine.
authors.affiliation: Microbial Chemistry Research Center, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan. hashizumeh@bikaken.or.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Hashizume
authors.forename: Masayuki
authors.initials: M
authors.lastname: Igarashi
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Sawa
authors.forename: Hayamitsu
authors.initials: H
authors.lastname: Adachi
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nishimura
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Akamatsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047630:Depsipeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D053528:Lysobacter / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D005227:Fatty Acids; C535087:tripropeptin aiC