Brain lesions in cerebral venous sinus thrombosis.
OBJECTIVE
Analyze the relationship between the location and extent of sinus thrombosis and presence and severity of brain lesions.


METHODS
Retrospective chart and neuroimaging review of patients with documented CVST. A CVST score was devised to quantify the extent of cerebral venous sinus thrombosis.


RESULTS
Nineteen of 56 (34%) patients had brain lesions. The extent of sinus thrombus was associated with increased risk of brain lesions (CVST score 1.9 among patients without brain lesions versus 3.1 in those with lesions; P=0.006). Age, sex, and acquired or hereditary thrombophilias were not associated with the risk of parenchymal lesions. Functional outcomes were favorable even in patients with extensive CVST and parenchymal lesions at presentation.


CONCLUSIONS
The extent of the sinus involvement correlates with the risk of brain lesions in patients with CVST, but additional factors might also contribute to their occurrence.
Zubkov
Alexander Y
AY
Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
McBane
Robert D
RD
Brown
Robert D
RD
Rabinstein
Alejandro A
AA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020520:Brain Infarction / Q000453:epidemiology* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012851:Sinus Thrombosis, Intracranial / Q000453:epidemiology* / Q000473:pathology*; D019851:Thrombophilia / Q000453:epidemiology; D055815:Young Adult