Collapsing glomerulopathy: beyond serendipity in mouse genetics.
Clinical correlates suggest that collapsing glomerulopathy results from the pathogenic interaction between patients' intractable genetic susceptibilities and environmental insults. When the environmental insults include a virus that introduces its own pathogenic genes, the interactions become more complex. Chan et al. combine reverse and forward genetic techniques in mice toward understanding this complexity with HIV and identify candidate genetic modifiers of collapsing glomerulopathy.
Nelson
Peter J
PJ
Division of Nephrology, Smilow Research Center, New York University School of Medicine, New York, NY 10016, USA. peter.nelson2@nyumc.org
Bruggeman
Leslie A
LA
D000818:Animals; D004777:Environment; D020022:Genetic Predisposition to Disease; D005921:Glomerulonephritis / Q000235:genetics*; D015658:HIV Infections; D006801:Humans; D051379:Mice