title: Would self-expanding stent occlude middle cerebral artery perforators?
abstract: OBJECTIVE
  A major concern of intracranial stenting is perforator infarction. It is unclear whether the sustained radial force of a self-expanding stent or subsequent stent restenosis would cause late occlusion of perforators.
  
  
  METHODS
  We compared the baseline and poststent (>or=4 months) MRI scans of patients who underwent self-expanding stenting for recurrent ischemic symptoms attributed to a MCA stenosis >or=60%. New infarcts in the ipsilateral striatocapsular region were recorded.
  
  
  RESULTS
  MCA stenting was technically successful in 23 of 24 recruited patients. No new perforator territory infarct was found in follow-up MRI scans of all recruited patients. Postoperatively, all patients reported no further TIA or stroke over a median follow-up of 15 months.
  
  
  CONCLUSIONS
  The use of a self-expanding stent in patients with high-grade MCA stenosis may not pose a major risk to the perforators.
authors.affiliation: Department of Medicine and Therapeutics, Division of Neurology, Prince of Wales Hospital, The Chinese University of Hong Kong. drtleung@cuhk.edu.hk
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Leung
authors.forename: Simon C H
authors.initials: SC
authors.lastname: Yu
authors.forename: Wynnie W M
authors.initials: WW
authors.lastname: Lam
authors.forename: Anne Y Y
authors.initials: AY
authors.lastname: Chan
authors.forename: Alexander Y L
authors.initials: AY
authors.lastname: Lau
authors.forename: Lawrence K S
authors.initials: LK
authors.lastname: Wong
mesh_terms: D000328:Adult; D000368:Aged; D017130:Angioplasty; D001241:Aspirin / Q000627:therapeutic use; D000077144:Clopidogrel; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000209:etiology*; D002546:Ischemic Attack, Transient / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011446:Prospective Studies; D015607:Stents / Q000009:adverse effects*; D020521:Stroke / Q000601:surgery*; D013988:Ticlopidine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine; D001241:Aspirin