Nanoscale oxidative patterning of metallic surfaces to modulate cell activity and fate.
In the field of regenerative medicine, nanoscale physical cuing is clearly becoming a compelling determinant of cell behavior. Developing effective methods for making nanostructured surfaces with well-defined physicochemical properties is thus mandatory for the rational design of functional biomaterials. Here, we demonstrate the versatility of simple chemical oxidative patterning to create unique nanotopographical surfaces that influence the behavior of various cell types, modulate the expression of key determinants of cell activity, and offer the potential of harnessing the power of stem cells. These findings promise to lead to a new generation of improved metal implants with intelligent surfaces that can control biological response at the site of healing.
Vetrone
Fiorenzo
F
Universite de Montreal, Montreal, Quebec H3C 3J7, Canada.
Variola
Fabio
F
Tambasco de Oliveira
Paulo
P
Zalzal
Sylvia Francis
SF
Yi
Ji-Hyun
JH
Sam
Johannes
J
Bombonato-Prado
Karina F
KF
Sarkissian
Andranik
A
Perepichka
Dmitrii F
DF
Wuest
James D
JD
Rosei
Federico
F
Nanci
Antonio
A
D000818:Animals; D002448:Cell Adhesion; D049109:Cell Proliferation; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006801:Humans; D008670:Metals / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010084:Oxidation-Reduction; D013499:Surface Properties
D008670:Metals