Nataxazole, a new benzoxazole derivative with antitumor activity produced by Streptomyces sp. Tü 6176.
The new benzoxazole derivative nataxazole was isolated from Streptomyces sp. (strain Tü 6176). Nataxazole is related in structure to the potent antitumor compounds UK-1 and AJI9561 and showed similar strong growth inhibitory activity against various human tumor cell lines.
Sommer
Patricia S M
PS
Centro de Biociencias, Universidade Federal do Rio Grande do Norte, Natal, Brasil.
Almeida
Rosemary C
RC
Schneider
Kathrin
K
Beil
Winfried
W
Süssmuth
Roderich D
RD
Fiedler
Hans-Peter
HP
D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001583:Benzoxazoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*
D000970:Antineoplastic Agents; D001583:Benzoxazoles; C540755:nataxazole