title: SU-8 microprobe with microelectrodes for monitoring electrical impedance in living tissues.
abstract: This paper presents a minimally invasive needle-shaped probe capable of monitoring the electrical impedance of living tissues. This microprobe consists of a 160 microm thick SU-8 substrate containing four planar platinum (Pt) microelectrodes. We design the probe to minimize damage to the surrounding tissue and to be stiff enough to be inserted in living tissues. The proposed batch fabrication process is low cost and low time consuming. The microelectrodes obtained with this process are strongly adhered to the SU-8 substrate and their impedance does not depend on frequency variation. In vitro experiments are compared with previously developed Si and SiC based microprobes and results suggest that it is preferable to use the SU-8 based microprobes due to their flexibility and low cost. The microprobe is assembled on a flexible printed circuit FPC with a conductive glue, packaged with epoxy and wired to the external instrumentation. This flexible probe is inserted into a rat kidney without fracturing and succeeds in demonstrating the ischemia monitoring.
authors.affiliation: IKERLAN-IK4, Paseo J. M. Arizmendiarrieta 2, 20.500 Mondragón, Spain. mtijero@ikerlan.es
authors.forename: M
authors.initials: M
authors.lastname: Tijero
authors.forename: G
authors.initials: G
authors.lastname: Gabriel
authors.forename: J
authors.initials: J
authors.lastname: Caro
authors.forename: A
authors.initials: A
authors.lastname: Altuna
authors.forename: R
authors.initials: R
authors.lastname: Hernández
authors.forename: R
authors.initials: R
authors.lastname: Villa
authors.forename: J
authors.initials: J
authors.lastname: Berganzo
authors.forename: F J
authors.initials: FJ
authors.lastname: Blanco
authors.forename: R
authors.initials: R
authors.lastname: Salido
authors.forename: L J
authors.initials: LJ
authors.lastname: Fernández
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D004852:Epoxy Compounds / Q000737:chemistry*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D007511:Ischemia / Q000175:diagnosis* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D008839:Microelectrodes; D008904:Miniaturization; D009339:Needles; D010992:Plethysmography, Impedance / Q000295:instrumentation* / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014159:Transducers
chemical_list: D004852:Epoxy Compounds; D011108:Polymers; C520895:SU-8 compound