title: Variant in RGS2 moderates posttraumatic stress symptoms following potentially traumatic event exposure.
abstract: Polymorphisms in the RGS2 (regulator of G-protein signaling 2) gene were found to be associated with anxious behavior in mice and anxiety in humans. We examined whether rs4606, a single nucleotide polymorphism (SNP) of RGS2, and social support moderated risk for PTSD in an epidemiologic sample. The study examines 607 adults from the 2004 Florida Hurricanes study who returned buccal DNA samples via mail. rs4606 was associated with increased symptoms of posthurricane PTSD symptoms under conditions of high hurricane exposure and low social support (P<.05). Further, this polymorphism was associated with lifetime PTSD symptoms under conditions of lifetime exposure to a potentially traumatic event, and low social support (P<.001). These gene by environment interactions remained significant after adjustment for sex, ancestry, and age. RGS2 rs4606 modifies risk of postdisaster and lifetime PTSD symptoms under conditions of high stressor exposure. This is the first demonstration of gene-environment interaction for this locus.
authors.affiliation: Department of Psychiatry, Medical University of South Carolina, Charleston, SC, USA. amstadt@musc.edu
authors.forename: Ananda B
authors.initials: AB
authors.lastname: Amstadter
authors.forename: Karestan C
authors.initials: KC
authors.lastname: Koenen
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Ruggiero
authors.forename: Ron
authors.initials: R
authors.lastname: Acierno
authors.forename: Sandro
authors.initials: S
authors.lastname: Galea
authors.forename: Dean G
authors.initials: DG
authors.lastname: Kilpatrick
authors.forename: Joel
authors.initials: J
authors.lastname: Gelernter
mesh_terms: D055867:Cyclonic Storms; D005260:Female; D005838:Genotype; D006801:Humans; D008016:Life Change Events; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D015995:Prevalence; D020710:RGS Proteins / Q000235:genetics*; D012307:Risk Factors; D012944:Social Support; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology*
chemical_list: D020710:RGS Proteins; C087182:RGS2 protein, human