Development of alpha-tocopherol acetate nanoparticles: influence of preparative processes.
We studied different methods of preparing alpha-tocopherol acetate (ATA) nanoparticles, which are to be used in targeting the lungs as aerosols in order to prevent cigarette smoke toxicity. Poly-(lactide) nanoparticles were prepared using nanoprecipitation and solvent evaporation techniques, which produced, respectively, too small and too large nanoparticles to be aerosolized. The emulsification-diffusion method produced 2 months stable nanoparticles with a size between (500-700 nm). Increasing ATA concentration (1-7 mg/mL) induced a decrease in the association rate (97-93%) and in the adsorbed ATA rate (7-4.5%), which was associated with variations of Zeta potentials (-27.5 to -24.3 mV) and decrease in polymeric wall thickness and density.
Anais
J P
JP
Pharmacy Department, CHU Henri MONDOR, Creteil, France.
Razzouq
N
N
Carvalho
M
M
Fernandez
C
C
Astier
A
A
Paul
M
M
Astier
A
A
Fessi
H
H
Lorino
A M
AM
D000336:Aerosols / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D008168:Lung / Q000378:metabolism; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D014026:Nicotiana / Q000633:toxicity; D014028:Tobacco Smoke Pollution / Q000517:prevention & control; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use
D000336:Aerosols; D000975:Antioxidants; D004655:Emulsions; D014028:Tobacco Smoke Pollution; D024502:alpha-Tocopherol