title: [Leg ulcer in mixed connective tissue disease. Resolution during sitaxsentan therapy].
abstract: Leg ulcers may result in serious morbidity in patients with connective tissue diseases and Raynaud's phenomenon (RP). We describe a 35-year-old woman with mixed connective tissue disease who suffered from leg ulcers refractory to iloprost. When the patient was treated with the selective endothelin A receptor antagonist sitaxsentan for pulmonary arterial hypertension, the ulcers improved within 4 weeks and resolved completely thereafter. In addition, severity of RP ameliorated markedly. Further evaluation of sitaxsentan in patients with connective tissue diseases suffering from ischemic skin ulcers is required.
authors.affiliation: Medizinische Klinik und Poliklinik D, Universitätsklinikum Münster, Albert-Schweitzer-Str. 33, 48149 Münster. beckerhe@mednet.uni-muenster.de
authors.forename: H
authors.initials: H
authors.lastname: Becker
authors.forename: C
authors.initials: C
authors.lastname: Sunderkoetter
authors.forename: P
authors.initials: P
authors.lastname: Willeke
authors.forename: W
authors.initials: W
authors.lastname: Domschke
authors.forename: M
authors.initials: M
authors.lastname: Gaubitz
authors.forename: M
authors.initials: M
authors.lastname: Mohr
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage*; D007871:Leg Ulcer / Q000150:complications* / Q000188:drug therapy*; D011928:Raynaud Disease / Q000150:complications* / Q000188:drug therapy*; D012595:Scleroderma, Systemic / Q000150:complications* / Q000188:drug therapy*; D013876:Thiophenes / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D007555:Isoxazoles; D013876:Thiophenes; C106276:sitaxsentan