[Prediction of the B cell epitopes for the major outer membrane protein of Chlamydia trachomatis].
To predict the B cell epitopes for major outer membrane protein (MOMP) of Chlamydia trachomatis (CT), the secondary structure of CT MOMP was predicted by the methods of GOR based on the sequence of amino acids of E serotype CT MOMP. By combining the comprehensive analysis of transmembrane domain, hydrophilicity profile, surface probability, antigenic index and average flexibility, the B cell predominant epitopes of CT MOMP were further predicted. The N-terminal No. 73-81, 217-225, 377-386, 261-270 and 161-175 were the predominant B cell epitopes. Prediction of the B cell epitopes for the CT MOMP by the multi-parameters is helpful for the identification of B cell epitopes.
Zhu
Shanli
S
Department of Microbiology & Immunology, Wenzhou Medical College, Wenzhou 325000, China.
Shi
Zhaohui
Z
Wang
Pengfei
P
Li
Wenshu
W
Zhang
Lifang
L
D000595:Amino Acid Sequence; D000942:Antigens, Bacterial / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000145:classification / Q000276:immunology*; D018985:Epitopes, B-Lymphocyte / Q000276:immunology*; D008969:Molecular Sequence Data; D018272:Porins / Q000276:immunology*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D012703:Serotyping
D000942:Antigens, Bacterial; D018985:Epitopes, B-Lymphocyte; D018272:Porins; C071677:omp1 protein, Chlamydia trachomatis