title: [Diagnostics of microcalcifications from minimally invasive biopsies in mammography screening: results from the prevalence phase].
abstract: BACKGROUND
  In mammography screening programmes carried out according to European guidelines, minimally invasive biopsies (MIB) are performed on up to 3% of participants. The aim of this study was to analyse the spectrum of histopathological findings including B categories in MIBs with microcalcifications compared to MIBs without microcalcifications.
  
  
  METHODS
  Prospectively collected histological findings of MIBs taken during the period July 2006 to June 2007 were analysed using the Breast Screening Pathology Database of the Reference Centre in Münster.
  
  
  RESULTS
  Of the 4,326 MIBs investigated, 2,161 were benign (B1-B3) whereas 2,165 were malignant (B4-B5) resulting in an overall malignancy rate of 50.04%. Of the MIBs 1,809 contained microcalcifications and 2,517 did not. Cases with microcalcifications showed a different distribution of B categories: B2 was found in 44.5% versus 24.2%, B3 in 18.2% versus 5.5% and the malignancy rate of cases with microcalcifications was 36.8% versus 59.5%. Of all cases of ductal carcinoma in situ (DCIS) detected in the screening programme, 83.35% were diagnosed in MIBs containing microcalcifications.
  
  
  CONCLUSIONS
  MIBs containing microcalcifications showed a different spectrum of diagnoses, especially higher rates of B3 lesions. Even though MIBs without microcalcifications showed a higher overall malignancy rate, most cases of DCIS were diagnosed in MIB containing microcalcifications.
authors.affiliation: Brust-Screening-Pathologie Gerhard Domagk-Institut für Pathologie, Universitätsklinikum Münster, Domagkstr 17, 48149, Münster, Deutschland.
authors.forename: D
authors.initials: D
authors.lastname: Hungermann
authors.forename: S
authors.initials: S
authors.lastname: Weigel
authors.forename: E
authors.initials: E
authors.lastname: Korsching
authors.forename: W
authors.initials: W
authors.lastname: Heindel
authors.forename: W
authors.initials: W
authors.lastname: Böcker
authors.forename: T
authors.initials: T
authors.lastname: Decker
mesh_terms: D001706:Biopsy; D001941:Breast Diseases / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D005858:Germany; D006801:Humans; D008327:Mammography; D008403:Mass Screening