Venous haemodynamics: what we know and don't know.
The presence of haemodynamic abnormalities in chronic venous disease (CVD) has been well established. The relationships between these abnormalities and clinical manifestations, or natural history of CVD, are complex and remain to be investigated. Flow-mediated processes and mechanisms unrelated to blood flow may play an important role in the pathophysiology of CVD. Current state of knowledge makes questionable a possibility of building treatment strategies based on a single simplified model of the disease. As an example of such simplified approach, CHIVA introduces an opportunity to critically assess the gaps in knowledge in venous pathophysiology.
Lurie
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Department of Surgery, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. flurie@kistnerveinclinic.com
D002908:Chronic Disease; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D014680:Veins / Q000502:physiology*; D014689:Venous Insufficiency / Q000503:physiopathology* / Q000628:therapy