[Study of effects of dietary fatty acids on the serum lipids in hypercholesterolemic subjects].
OBJECTIVE
To study the effects of dietary fatty acids on the serum lipids in hypercholesterolemic subjects.


METHODS
All 297 residents with hypercholesterolemia were enrolled in Guangzhou. The dietary composition and the changes in serum lipid levels during the 6-month follow-up were analyzed.


RESULTS
(1) 297 subjects were enrolled and 281 subjects (88 male, 193 female) completed the 6-month follow-up. The serum TC concentration of the subjects was (6.09+/-0.68) mmol/L at baseline. (2) According to the percentage of energy from total fat, all of the subjects were divided into three groups, including total fat % en<25% (group I, 90 subjects), 25%-30% (group II, 97 subjects), >30% (group III, 94 subjects). The reduction of TC and LDL-C in group I and group II was greater than that in group III. (3) According to the percentage of energy from SFA, all of the subjects were divided into three groups, including SFA % en<7% (group I, 81 subjects), 7%-10% (group II, 129 subjects), >10% (group III, 71 subjects). The reduction of TC and LDL-C in group I and group II was greater than that in group III. (4) All of the subjects were divided into three groups, according to the percentage of energy from MUFA, including MUFA % en<10% (group I, 93 subjects), 10%-13% (group II, 106 subjects), >13% (group III, 82 subjects). The reduction of TC and LDL-C in group II was greater than that in group I and group III. (5) All of the subjects were divided into three groups according to the percentage of energy from PUFA, including PUFA % en<7% (88 subjects), 7%-9% (94 subjects), >9% (99 subjects). No significant difference was found among the reduction of serum lipids in the three groups.


CONCLUSIONS
Dietary total fat % en<or=30%, SFAs % en<or=10% and MUFAs % en 10%-13% should be conductive to reduce the serum lipids of patients with hyperlipidemia.
Zhou
Xiao-xing
XX
Faculty of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
Zhang
Bo
B
Huang
Li-li
LL
Xu
Ying
Y
Sun
Li-na
LN
Zhuo
Shu-yu
SY
Chen
Yu-ming
YM
Su
Yi-xiang
YX
D000328:Adult; D000368:Aged; D004041:Dietary Fats / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000209:etiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D008055:Lipids