title: Transcriptional signature following inhibition of early-stage cell wall biosynthesis in Staphylococcus aureus.
abstract: To facilitate mode of action studies on antibacterial inhibitors of early-stage cell wall biosynthesis (CWB), we determined the transcriptional response of Staphylococcus aureus to depletion/inhibition of enzymes in this pathway by DNA microarray analysis. We identified a transcriptional signature distinct from that previously observed following exposure to inhibitors of late-stage CWB.
authors.affiliation: Antimicrobial Research Centre and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom.
authors.forename: A J
authors.initials: AJ
authors.lastname: O'Neill
authors.forename: J A
authors.initials: JA
authors.lastname: Lindsay
authors.forename: K
authors.initials: K
authors.lastname: Gould
authors.forename: J
authors.initials: J
authors.lastname: Hinds
authors.forename: I
authors.initials: I
authors.lastname: Chopra
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002473:Cell Wall / Q000187:drug effects* / Q000378:metabolism; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents