New principles from seeds of Nigella sativa.
A new triterpene saponin and known steroidal glucoside were isolated from the alcohol extract, and a new cycloartenol from n-hexane extract of seeds of Nigella sativa L. and were identified as 3-O-[beta-D-xylopyranosyl-(1-->2)-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranosyl]-11-methoxy-16,23-dihydroxy-28-methylolean-12-enoate (1), stigma-5,22-dien-3-beta-D-glucopyranoside (2) and cycloart-23-methyl-7,20, 22-triene-3beta,25-diol (3), respectively. They were characterised on the basis of spectral analysis and comparison with literature data. The hexane and alcohol extract of the seeds showed antimicrobial activity. The antioxidant activity of hexane extract is also described.
Mehta
B K
BK
School of Studies in Chemistry and Biochemistry, Vikram University, Ujjain, India. bkmehta@yahoo.com
Pandit
Vikas
V
Gupta
Meenal
M
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000378:metabolism; D002240:Carbohydrate Sequence; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006834:Hydrazines / Q000378:metabolism; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D031881:Nigella sativa / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009904:Optical Rotation; D010851:Picrates; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012639:Seeds / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D012503:Saponins; D014315:Triterpenes; C004931:1,1-diphenyl-2-picrylhydrazyl