title: Effect of dietary soy protein on tumor necrosis factor productivity in macrophages from nephritic and hepatoma-bearing rats.
abstract: The present study investigated the effect of dietary soy protein isolate (SPI) on tumor necrosis factor-alpha (TNF) productivity in peritoneal macrophages from nephritic and hepatoma-bearing rats. Dietary SPI significantly inhibited the elevated production of TNF by lipopolysaccharide-stimulated macrophages in nephritic and hepatoma-bearing rats compared with dietary casein, while it exerted no influence on the TNF productivity in normal rats. Removal of the minor components contained in SPI by ethanol extraction could significantly or partially restore the reduced TNF production caused by SPI in nephritic and hepatoma-bearing rats, respectively. These results suggest that dietary SPI could suppress the enhanced productivity of TNF associated with the progression of nephritis and hepatoma, and some factors existing in the ethanol extract of SPI are suggested to be involved in suppressing TNF productivity by macrophages.
authors.affiliation: Department of Applied Biological Science, Tokyo Noko University, Fuchu, Tokyo, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Komatsu
authors.forename: Junko
authors.initials: J
authors.lastname: Nagata
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kaneko
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Yamada
authors.forename: Daisuke
authors.initials: D
authors.lastname: Moriya
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Miura
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yagasaki
mesh_terms: D000818:Animals; D002364:Caseins / Q000494:pharmacology* / Q000627:therapeutic use; D005983:Glutens / Q000494:pharmacology* / Q000627:therapeutic use; D008070:Lipopolysaccharides; D008114:Liver Neoplasms, Experimental / Q000178:diet therapy*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009393:Nephritis / Q000178:diet therapy*; D051381:Rats; D017208:Rats, Wistar; D030262:Soybean Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D013025:Glycine max; D014908:Triticum; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
chemical_list: D002364:Caseins; D008070:Lipopolysaccharides; D030262:Soybean Proteins; D014409:Tumor Necrosis Factor-alpha; D005983:Glutens