title: Synthesis, radiosynthesis, and in vitro evaluation of [131I]-5-iodo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-yl)-ethyl]-2-methoxy-benzamide as a potential tumor imaging agent.
abstract: This work reports the synthesis, radiolabeling and preliminary in vitro evaluation of [(131)I]-5-iodo-N-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-yl)-ethyl]-2-methoxy-benzamide. The tributylstannylprecursor was synthesized with a yield of 38%. Radiolabeling was performed using an electrophilic iododestannylation. Tracer yield was 94%, radiochemical purity was >95%. The tracer showed high uptake in MCF-7 breast cancer cell line and therefore will be evaluated further.
authors.affiliation: The Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Ministry of Health, 20 Qianrong Road, Wuxi 214063, China.
authors.forename: Yu Ping
authors.initials: YP
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Dong Hui
authors.initials: DH
authors.lastname: Pan
mesh_terms: D001549:Benzamides / Q000138:chemical synthesis*; D045744:Cell Line, Tumor; D006801:Humans; D007457:Iodine Radioisotopes; D007546:Isoquinolines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: C539911:5-iodo-N-(2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl)-2-methoxybenzamide; D001549:Benzamides; D007457:Iodine Radioisotopes; D007546:Isoquinolines; D019275:Radiopharmaceuticals