SNAP-25 in neuropsychiatric disorders.
SNAP-25 (synaptosomal-associated protein of 25 kDa) is a plasma membrane protein that, together with syntaxin and the synaptic vesicle protein VAMP/synaptobrevin, forms the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) docking complex for regulated exocytosis. SNAP-25 also modulates different voltage-gated calcium channels, representing therefore a multifunctional protein that plays essential roles in neurotransmitter release at different steps. Recent genetic studies of human populations and of some mouse models implicate alterations in SNAP-25 gene structure, expression, and/or function in contributing directly to these distinct neuropsychiatric and neurological disorders.
Corradini
Irene
I
Department of Medical Pharmacology, University of Milan, Milano, Italy.
Verderio
Claudia
C
Sala
Mariaelvina
M
Wilson
Michael C
MC
Matteoli
Michela
M
D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000378:metabolism; D004827:Epilepsy / Q000378:metabolism; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism* / Q000523:psychology*; D012559:Schizophrenia / Q000378:metabolism; D050825:Synaptosomal-Associated Protein 25 / Q000235:genetics / Q000378:metabolism*
D050825:Synaptosomal-Associated Protein 25