title: Acute allergic reaction due to milk proteins contaminating lactose added to corticosteroid for injection.
abstract: We encountered two patients with severe cow's milk allergy who reacted strongly to an injection of methylprednisolone sodium succinate (Sol-Medrol 40 mg Pfizer, Japan). They came to our hospital because of an asthmatic attack or urticaria and were treated with Sol-Medrol 40 mg. After the injection, the allergic reaction was immediate. Skin prick tests demonstrated that the beta-lactoglobulin contaminating the lactose of the drug preparation caused the immediate allergic reaction.
authors.affiliation: Children's Medical Center, Fujisawa City Hospital, Yokohama City, Kanagawa, Japan. asuka_milk@yahoo.co.jp
authors.forename: Asuka
authors.initials: A
authors.lastname: Eda
authors.forename: Kazuko
authors.initials: K
authors.lastname: Sugai
authors.forename: Hiromi
authors.initials: H
authors.lastname: Shioya
authors.forename: Asako
authors.initials: A
authors.lastname: Fujitsuka
authors.forename: Setsuko
authors.initials: S
authors.lastname: Ito
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Iwata
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Funabiki
mesh_terms: D000208:Acute Disease; D002648:Child; D002675:Child, Preschool; D004340:Drug Contamination; D005260:Female; D006801:Humans; D007267:Injections; D007782:Lactoglobulins / Q000276:immunology*; D007785:Lactose / Q000032:analysis; D008776:Methylprednisolone Hemisuccinate / Q000009:adverse effects*; D016269:Milk Hypersensitivity / Q000209:etiology*
chemical_list: D007782:Lactoglobulins; D008776:Methylprednisolone Hemisuccinate; D007785:Lactose