title: Acetylcholinesterase inhibitor treatment is associated with relatively slow cognitive decline in patients with Alzheimer's disease and AD + DLB.
abstract: Dementia can be caused by different diseases including Alzheimer's disease (AD), dementia with Lewy bodies (DLB), or both (AD + DLB). University of Kentucky AD Center pathologically-diagnosed AD and AD + DLB cases were evaluated who had three or more longitudinal antemortem mental status examinations (n = 156). Patients with important concomitant pathology (n = 5) or patients that were profoundly demented at recruitment (intake MMSE < 20; n = 86) were excluded to strengthen our ability to test the association of specific clinical and pathological indices. Patients with pathologically-diagnosed AD + DLB (n = 25) lost cognitive capacity faster than patients with AD alone (n = 40). In both diseases, treatment with acetylcholinesterase inhibitors was associated with a slower rate of cognitive decline.
authors.affiliation: Department of Pathology, University of Kentucky Medical Center, University of Kentucky, Lexington, KY, USA. pnels2@email.uky.edu
authors.forename: Peter T
authors.initials: PT
authors.lastname: Nelson
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kryscio
authors.forename: Erin L
authors.initials: EL
authors.lastname: Abner
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Schmitt
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Jicha
authors.forename: Marta S
authors.initials: MS
authors.lastname: Mendiondo
authors.forename: Greg
authors.initials: G
authors.lastname: Cooper
authors.forename: Charles B
authors.initials: CB
authors.lastname: Smith
authors.forename: William R
authors.initials: WR
authors.lastname: Markesbery
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000523:psychology*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000523:psychology*; D016208:Databases, Factual; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D008297:Male; D015233:Models, Statistical; D009483:Neuropsychological Tests
chemical_list: D002800:Cholinesterase Inhibitors