title: Correlation of tissue Doppler and two-dimensional speckle myocardial velocities and comparison of derived ratios with invasively measured left ventricular filling pressures.
abstract: BACKGROUND
  There are a paucity of data comparing spectral and color tissue Doppler (TD) with non-Doppler, speckle-based myocardial velocities, and it is unknown how early transmitral diastolic velocity/mitral annular velocity (E/Ea) calculated using speckle velocities compares with TD-derived E/Ea.
  
  
  METHODS
  We measured systolic (Sa), Ea, and late diastolic (Aa) myocardial velocities using these 3 methods and compared calculated E/Ea with invasively measured left ventricular (LV) hemodynamics. Consecutive patients referred for cardiac catheterization were imaged, and LV pre-A contraction pressure was measured by retrograde aortic cardiac catheterization.
  
  
  RESULTS
  Fifty patients (22 women, 44%) were studied with a mean age of 54 +/- 10 years and a mean LV ejection fraction of 48% +/- 19%. Speckle and color TD Sa, Ea, and Aa were significantly lower than spectral TD velocities, resulting in higher E/Ea values compared with spectral TD E/Ea. Spectral TD E/Ea (R = 0.65, P < .001), color TD E/Ea (R = 0.69, P < .001), and speckle E/Ea (R = 0.76, P < .001) all correlated with LV pre-A pressure. Different cutoff values were needed for spectral TD, color TD, and speckle E/Ea to predict LV pre-A pressure >or= 15 mm Hg; spectral E/Ea > 14 (area under the curve [AUC] = 0.87, P < .001, sensitivity = 83%, specificity = 77%), color E/Ea > 16 (AUC = 0.89, P < .0001, sensitivity = 79%, specificity = 81%), and speckle E/Ea > 18 (AUC = 0.87, P < .0001, sensitivity = 88%, specificity = 74%; P = not significant for comparisons between the groups).
  
  
  CONCLUSIONS
  Spectral TD, color TD, and speckle imaging measure different velocities, and consequently different cutoff values are needed for E/Ea to predict invasively measured LV filling pressure.
authors.affiliation: Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Texas 77030, USA. hishamd@bcm.edu
authors.forename: Hisham
authors.initials: H
authors.lastname: Dokainish
authors.forename: Ranjita
authors.initials: R
authors.lastname: Sengupta
authors.forename: Manu
authors.initials: M
authors.lastname: Pillai
authors.forename: Jaromir
authors.initials: J
authors.lastname: Bobek
authors.forename: Nasser
authors.initials: N
authors.lastname: Lakkis
mesh_terms: D000465:Algorithms; D018618:Echocardiography, Doppler, Color / Q000379:methods*; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*