Electrodiagnostic and clinical aspects of Guillain-Barré syndrome: an analysis of 142 cases.
BACKGROUND
The incidence of Guillain-Barré syndrome (GBS) and its subtypes varies throughout the world.


OBJECTIVE
We present a retrospective analysis of 142 GBS cases, treated at our center, aimed at classifying GBS electrophysiologically, to study the sequential electrophysiological changes in cases with acute inflammatory demyelinating polyradiculoneuropathy (AIDP), and to look for any clinical and cerebrospinal fluid parameters that can also help in distinguishing the subtypes.


RESULTS
One hundred twenty-one (85.2%) cases had AIDP, 15 (10.6%) had acute motor axonal neuropathy, and 6 (4.2%) were unclassifiable.


CONCLUSIONS
Motor conduction blocks and temporal dispersion could be observed from days 3 and 5 onward, respectively. Progression of motor conduction slowing in AIDP was most impressive in the median nerves. Varying affection of deep tendon reflexes, cranial nerves, and cerebrospinal fluid albuminocytological dissociation can also help make a distinction between AIDP and acute motor axonal neuropathy. Sural sparing, a marker of demyelinating neuropathy, is more commonly seen in later than in early stages of AIDP.
Gupta
Deepak
D
Department of Neurology and daggerAchutha Menon Centre For Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Trivandrum, Kerala, India. dg14_9@rediffmail.com
Deepak
Gupta
G
Nair
Muraleedharan
M
Muraleedharan
Nair
N
Baheti
Neeraj N
NN
Sarma
P Sankara
PS
Sarma
Sankara P
SP
Kuruvilla
Abraham
A
Abraham
Kuruvilla
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000418:Albumins / Q000134:cerebrospinal fluid; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D004558:Electric Stimulation; D004568:Electrodiagnosis / Q000379:methods; D005260:Female; D020275:Guillain-Barre Syndrome / Q000134:cerebrospinal fluid / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D055815:Young Adult
D000418:Albumins