Extramedullary myeloma in an HIV-seropositive subject. Literature review and report of an unusual case.
Myeloma is characterized by monoclonal bone marrow plasmacytosis, the presence of M-protein in serum and/or in urine and osteolytic bone lesions. HIV-seropositive subjects with myeloma are younger at the time of diagnosis of the tumour and usually the myeloma has a more aggressive clinical course than it does in HIV-seronegative subjects. A case of an HIV-seropositive woman in whom myeloma was diagnosed following progressive swelling of the face, is reported. In addition to bone marrow plasmacytosis and the presence of M-protein in the serum, the patient had an extramedullary lesion affecting the oral cavity, maxilla, parotid gland and paranasal sinuses, and extending intracranially and intraorbitally.
Feller
Liviu
L
Department of Periodontology and Oral Medicine, School of Dentistry, University of Limpopo, Pretoria, South Africa. lfeller@ul.ac.za
White
Jason
J
Wood
Neil H
NH
Bouckaert
Michael
M
Lemmer
Johan
J
Raubenheimer
Erich J
EJ
D005153:Facial Neoplasms / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis