Experiment-specific models of ventricular electrical activation: construction and application.
Experimental intramural recordings of electrical activity at high resolution have been made in the in-vivo pig LV free wall. To analyze features of these recordings experiment-specific 3D computer models of tissue structures and electrical behavior around the recording sites were constructed. The construction of the models used novel tissue image registration, correction and feature extraction methods. Appropriate model conductivity parameters were deduced from measurements and used to replicate features of experimental recordings.
Trew
Mark L
ML
Auckland Bioengineering Institute, Department of Physiology, University of Auckland, New Zealand. m.trew@auckland.ac.nz
Caldwell
Bryan J
BJ
Barbarenda Gamage
Thiranja P
TP
Sands
Gregory B
GB
Smaill
Bruce H
BH
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D018780:Body Surface Potential Mapping / Q000379:methods*; D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology*; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology*; D013552:Swine; D016277:Ventricular Function, Left / Q000502:physiology*