title: "Flash" solvent-free synthesis of triazoles using a supported catalyst.
abstract: A solvent-free synthesis of 1,4-disubstituted-1,2,3-triazoles using neat azides and alkynes and a copper(I) polymer supported catalyst (Amberlyst) A21*CuI) is presented herein. As it provides the products in high yields and purities within minutes, this method thus being characterized as a "flash" synthesis, and was exemplified through the synthesis of a 24-compound library on a small scale.
authors.affiliation: Laboratoire de Pharmacologie Chimique et Génétique UMR8151 CNRS, U640 INSERM, IFR2769, Ecole Nationale Supérieure de Chimie de Paris, Paris, France. ibtissemj@yahoo.fr
authors.forename: Ibtissem
authors.initials: I
authors.lastname: Jlalia
authors.forename: Faouzi
authors.initials: F
authors.lastname: Meganem
authors.forename: Jean
authors.initials: J
authors.lastname: Herscovici
authors.forename: Christian
authors.initials: C
authors.lastname: Girard
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry; D015394:Molecular Structure; D012997:Solvents; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D012997:Solvents; D014230:Triazoles; D003300:Copper