Cumulative effects of consecutive running sessions on hemolysis, inflammation and hepcidin activity.
The effect of two running sessions completed within a 12-h period on hemolysis, inflammation, and hepcidin activity in endurance athletes was investigated. Ten males completed two experimental trials in a randomized, counterbalanced order. The two trials included (a) a one-running-session trial (T1) including 10 x 1 km interval repeats (90% peak VO2 velocity), and (b) a two-running-session trial (T2), comprising a continuous 10-km run (70% peak VO2 velocity), and a 10 x 1 km interval run (90% peak VO2 velocity) completed 12 h later. Interleukin-6 (IL-6), free hemoglobin (Hb), haptoglobin (Hp), iron, ferritin, and hepcidin were assessed post-exercise. After the T1 and T2 interval runs, free Hb was significantly increased and Hp significantly decreased (p <or= 0.05), with a cumulative effect shown in T2 after the second run (p <or= 0.05). The IL-6, serum iron, ferritin, and hepcidin activity were increased after each running session (p <or= 0.05), with no cumulative effect in T2. In conclusion, a cumulative effect of two running sessions on hemolysis was shown, but no similar effect with inflammation and hepcidin activity was evident.
Peeling
Peter
P
School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, WA, Australia. peelip01@student.uwa.edu.au
Dawson
Brian
B
Goodman
Carmel
C
Landers
Grant
G
Wiegerinck
Erwin T
ET
Swinkels
Dorine W
DW
Trinder
Debbie
D
D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism* / Q000652:urine; D018592:Cross-Over Studies; D005080:Exercise Test; D005293:Ferritins / Q000097:blood; D006242:Haptoglobins / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis / Q000502:physiology*; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000652:urine; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood; D008297:Male; D005082:Physical Exertion / Q000502:physiology; D012420:Running / Q000502:physiology*; D013997:Time Factors
D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D006242:Haptoglobins; D006454:Hemoglobins; D064451:Hepcidins; D015850:Interleukin-6; D005293:Ferritins; D007501:Iron