title: Extracranial radiosurgery--applications in the management of benign intradural spinal neoplasms.
abstract: Stereotactic radiosurgery has enabled the delivery of higher doses of radiation and decreased fractionation due to improved accuracy. Spinal radiosurgery has been increasingly utilized for the management of metastatic extradural spinal disease. However, surgical resection remains the primary treatment strategy for intradural spinal tumors. Preliminary evidence suggests that radiosurgical ablation with stereotactic radiation for intradural spinal lesions may be efficacious in certain clinical scenarios. Local tumor control, pain relief, and improvement in neurologic function with minimal morbidity have been reported in short-term follow-up. However, long-term efficacy of radiosurgery in the management of intradural spinal neoplasms necessitates further validation. As extracranial radiosurgery is a newly evolving modality, a continuative review of the current literature is appropriate. Until a standardized therapeutic window of safety and efficacy can be determined, the recommendation of radiosurgical applications for benign spinal tumors should be reserved for carefully selected cases.
authors.affiliation: Midwestern University, Glendale, AZ, USA.
authors.forename: Christine
authors.initials: C
authors.lastname: Saraceni
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Ashman
authors.forename: James S
authors.initials: JS
authors.lastname: Harrop
mesh_terms: D004307:Dose-Response Relationship, Radiation; D004388:Dura Mater / Q000601:surgery*; D006801:Humans; D011836:Radiation Tolerance; D016634:Radiosurgery / Q000379:methods*; D012371:Robotics; D013116:Spinal Cord / Q000528:radiation effects; D013120:Spinal Cord Neoplasms / Q000601:surgery*