Innate immunity and vaccines in chlamydial infection with special emphasis on Chlamydia pneumoniae.
Chlamydial infections are prevalent worldwide. Immunological events related to both innate and adaptive immunity during chlamydial infection can aid in recovery from the disease, but they can also cause harmful effects (immunopathology). The host genetic factors (variation in innate immunity and adaptive response-related genes) can predispose individuals to infection and its sequelae as well as determine the effects of intervention. No effective vaccine is available for human use. Modern technologies and data obtained using different 'omics' techniques (genomics, proteomics, transcriptomics and immunomics) might help in designing novel, more efficient vaccines, hopefully also against chlamydial infections.
Puolakkainen
Mirja
M
Department of Virology, Haartman Institute, University of Helsinki, Finland. mirja.puolakkainen@helsinki.fi
D001428:Bacterial Vaccines / Q000276:immunology*; D002690:Chlamydia Infections / Q000276:immunology* / Q000517:prevention & control*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate
D001428:Bacterial Vaccines