title: Endocrine and ingestive behavioral responses to fluid deprivation in sheep chronically exposed to ethanol.
abstract: Endocrine responses to fluid deprivation/restoration and preference for ethanol solution vs. water were assessed in sheep maintained for 5 months on a 10% ethanol solution as their sole source of fluid. Blood pressure, body weight, plasma composition and hormone levels of the alcohol maintained sheep were all within a normal range, except for high plasma concentrations of ANG II and ALDO. During fluid deprivation, AVP concentration increased and fluid-deprived sheep displayed a natriuresis and then a rehydration anti-natriuresis. Sheep did not drink the 10% ethanol solution avidly upon fluid restoration, preferring to drink steadily over the following 24 h; there was an associated increase in blood alcohol concentration (BAC). PRC, ANG II and ALDO all increased throughout the fluid restoration period, whereas plasma AVP and ANP gradually fell. In a separate experiment when water was also supplied to the sheep, they preferred water to 10% ethanol; however, alcohol intake was not eliminated. Overall, this degree of chronic consumption of 10% ethanol solution did not appear to adversely affect physiological mechanisms concerned with body fluid homeostasis after fluid deprivation conditions.
authors.affiliation: School of Psychological Science, La Trobe University, Victoria 3086, Australia. R.Weisinger@latrobe.edu.au
authors.forename: R S
authors.initials: RS
authors.lastname: Weisinger
authors.forename: D P
authors.initials: DP
authors.lastname: Begg
authors.forename: D A
authors.initials: DA
authors.lastname: Denton
authors.forename: A L R
authors.initials: AL
authors.lastname: Findlay
authors.forename: G A
authors.initials: GA
authors.lastname: Kennedy
authors.forename: B
authors.initials: B
authors.lastname: Purcell
authors.forename: L L
authors.initials: LL
authors.lastname: Walker
authors.forename: J R
authors.initials: JR
authors.lastname: Blair-West
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000428:Alcohol Drinking / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood*; D000704:Analysis of Variance; D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D002492:Central Nervous System Depressants / Q000494:pharmacology; D002755:Choice Behavior; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005518:Food Preferences / Q000187:drug effects / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects; D007018:Hypopituitarism; D014868:Water Deprivation / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
chemical_list: D002492:Central Nervous System Depressants; D000804:Angiotensin II; D001127:Arginine Vasopressin; D000431:Ethanol; D000450:Aldosterone