Synthesis of citrate-ciprofloxacin conjugates.
Two regioisomeric citrate-functionalized ciprofloxacin conjugates have been synthesized and their antimicrobial activities against a panel of clinically-relevant bacteria have been determined. Cellular uptake mechanisms were investigated using wild-type and ompF deletion strains of Escherichia coli K-12.
Md-Saleh
Siti R
SR
Department of Chemistry, University of York, Heslington, York, YO10 5DD, UK.
Chilvers
Emily C
EC
Kerr
Kevin G
KG
Milner
Stephen J
SJ
Snelling
Anna M
AM
Weber
Jan P
JP
Thomas
Gavin H
GH
Duhme-Klair
Anne-Kathrin
AK
Routledge
Anne
A
D002939:Ciprofloxacin / Q000138:chemical synthesis* / Q000494:pharmacology; D019343:Citric Acid / Q000138:chemical synthesis* / Q000494:pharmacology; D048168:Escherichia coli K12 / Q000187:drug effects / Q000235:genetics / Q000254:growth & development; D017353:Gene Deletion; D006801:Humans; D018272:Porins / Q000172:deficiency / Q000235:genetics; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000254:growth & development; D013211:Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000254:growth & development
C109237:OmpF protein; D018272:Porins; D019343:Citric Acid; D002939:Ciprofloxacin