title: Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice.
abstract: BACKGROUND
  The bark of Tectona grandis Linn. is traditionally used in the treatment of diabetes.
  
  
  OBJECTIVE
  The present study was undertaken to investigate the effect of ethanolic extract of bark of Tectona grandis Linn. (TG) in dexamethasone-induced insulin resistance in mice.
  
  
  METHODS
  Mice were treated with prestandardised dose of dexamethasone for 22 days and effect of TG at the doses of 50, 100 and 200 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD, catalase and LPO), and body weight were observed.
  
  
  RESULTS
  TG showed significant decrease in plasma glucose and serum triglyceride levels (p<0.01) at the dose of 100 and 200 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and catalase were significantly increased (p<0.01) and there was significant decrease (p<0.01) in level of LPO.
  
  
  CONCLUSIONS
  Hence it can be concluded that Tectona grandis may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.
authors.affiliation: Department of Pharmacology, Padm. Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune 411018, India. ghaisasmm@yahoo.com
authors.forename: Mahesh
authors.initials: M
authors.lastname: Ghaisas
authors.forename: Vijay
authors.initials: V
authors.lastname: Navghare
authors.forename: Abhijit
authors.initials: A
authors.lastname: Takawale
authors.forename: Vinit
authors.initials: V
authors.lastname: Zope
authors.forename: Mukesh
authors.initials: M
authors.lastname: Tanwar
authors.forename: Avinash
authors.initials: A
authors.lastname: Deshpande
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D003907:Dexamethasone; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D003964:Diaphragm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007333:Insulin Resistance; D008099:Liver / Q000201:enzymology; D051379:Mice; D008517:Phytotherapy; D000077205:Pioglitazone; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood; D029648:Verbenaceae
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D045162:Thiazolidinediones; D014280:Triglycerides; D003907:Dexamethasone; D000077205:Pioglitazone