title: Statistical evaluation of hemodynamic effects of regular use of sildenafil on the human corpora cavernosa.
abstract: BACKGROUND
  Sildenafil citrate is currently used on demand in the treatment of erectile failure, regardless of etiology. Nevertheless, recent data suggest a significant improvement in nocturnal penile erections in potent and impotent men taking a single dose at bedtime. The present study analyzes whether continuous use of sildenafil positively correlates with improvement of penile blood flow and treatment satisfaction referred by patients with erectile dysfunction (ED) of vascular origin.
  
  
  METHODS
  A total of 32 patients, mean age 54, with ED of vascular etiology, were evaluated at the beginning and at the end of our study using the International Index of Erectile Function (IIEF-5) and pharmaco-penile duplex ultrasonography during basic and dynamic phases. These patients were treated with sildenafil (50 mg) twice a week for 4 months. During pharmaco-penile duplex ultrasonography, we measured basal peak flow velocity, basal acceleration of peak flow in both cavernous arteries before intracavernous (i.c.) pharmaco-stimulation, maximum peak flow velocities and end-diastolic flow velocities after i.c. stimulation. The data observed were compared with those of 10 patients with ED who voluntarily decided not to take any treatment.
  
  
  CONCLUSIONS
  In this study, basal peak flow velocity, basal acceleration, maximum peak flow velocity and IIEF-5 scores were found to significantly increase after treatment. All differences were statistically significant (p < 0.05). Only few mild adverse effects were observed. Our data suggest that the regular use of sildenafil (50 mg) improves the blood flow in cavernous arteries increasing sexual performance in patients with ED of vascular origin.
authors.affiliation: Department of Urology, University of Florence, Florence, Italy. anatali@dada.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Natali
authors.forename: Marco
authors.initials: M
authors.lastname: Bartolini
authors.forename: Silvia
authors.initials: S
authors.lastname: Lucarini
authors.forename: Graziano
authors.initials: G
authors.lastname: Vignolini
authors.forename: Federico
authors.initials: F
authors.lastname: Nelli
authors.forename: Ilario
authors.initials: I
authors.lastname: Menchi
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D003627:Data Interpretation, Statistical; D004334:Drug Administration Schedule; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D018783:Impotence, Vasculogenic / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010413:Penis / Q000098:blood supply*; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D011687:Purines / Q000008:administration & dosage / Q000009:adverse effects; D012039:Regional Blood Flow / Q000187:drug effects; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D018616:Ultrasonography, Doppler, Duplex; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate