title: Effect of novel maize-based dietary fibers on postprandial glycemia and insulinemia.
abstract: BACKGROUND
  Postprandial hyperglycemia has been associated with increased oxidative stress and the development of diabetes, heart disease and all-cause mortality.
  
  
  OBJECTIVE
  To assess the effect of novel maize-based dietary fibers on postprandial glycemia and to assess the correlation between a rapid in vitro digestibility system and the blood glucose response.
  
  
  METHODS
  In a clinical study, 12 healthy volunteers were fed seven test beverages containing maize-based fiber ingredients (25g total carbohydrate) along with 2 control meals on separate occasions in random order. Capillary blood samples were obtained and the relative glycemic and insulinemic responses were assessed by calculating the incremental area under the 2 h blood response curves. In vitro digestibility studies of the test fibers and control were also undertaken to determine if these correlated with the clinical findings.
  
  
  RESULTS
  All test fibers resulted in significantly lower glycemic and insulinemic responses for the incremental area under the curve (iAUC) and at all time points compared with the control (P < 0.05). The in vitro digestibility curves were comparable to the cumulative in vivo iAUCs. In vitro data expressed as percent digestion correlated significantly with the in vivo iAUC for the first 30min of the test meal (P < 0.05).
  
  
  CONCLUSIONS
  These novel maize-based dietary fibers all produce lower postprandial glycemic and insulinemic responses than the control. While further assessment is necessary in beverage and foods containing these fibers, they may be effective in applications for dietary strategies to control diabetes and other chronic diseases. In addition, the in vitro digestibility assay correlated well with in vivo data and may be useful in guiding product development.
authors.affiliation: Department ofNutritional Sciences, Faculty of Medicine, University of Toronto, Glycemia Consulting, Clinical Nutrition & Risk Factor Modification Center, St Michael's Hospital, Toronto, Ontario, Canada. cyril.kendall@utoronto.ca
authors.forename: Cyril W C
authors.initials: CW
authors.lastname: Kendall
authors.forename: Amin
authors.initials: A
authors.lastname: Esfahani
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Hoffman
authors.forename: Annette
authors.initials: A
authors.lastname: Evans
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Sanders
authors.forename: Andrea R
authors.initials: AR
authors.lastname: Josse
authors.forename: Edward
authors.initials: E
authors.lastname: Vidgen
authors.forename: Susan M
authors.initials: SM
authors.lastname: Potter
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D004043:Dietary Fiber / Q000627:therapeutic use*; D004063:Digestion / Q000502:physiology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000178:diet therapy*; D007328:Insulin / Q000097:blood; D008297:Male; D019518:Postprandial Period; D003313:Zea mays
chemical_list: D001786:Blood Glucose; D004043:Dietary Fiber; D007328:Insulin