Duration of untreated prodromal symptoms and 12-month functional outcome of individuals at risk of psychosis.
Individuals seeking help from prodromal services may have been experiencing attenuated psychotic features and psychosocial impairments for a long period prior to referral. The effect of an extended duration of these untreated ;at risk' symptoms on patients' long-term functional outcome was assessed in a 12-month longitudinal observational study (n=49). A longer duration of untreated ;at risk' symptoms was correlated with a reduced improvement in Global Assessment of Functioning scores after 12 months (beta=-0.375, P=0.008). This effect was independent of age and gender and may have implications for the improvement of treatment strategies in pre-psychotic phases.
Fusar-Poli
P
P
OASIS, South London and Maudsley NHS Trust, and Institute of Psychiatry, King's College London, UK. p.fusar@libero.it
Meneghelli
A
A
Valmaggia
L
L
Allen
P
P
Galvan
F
F
McGuire
P
P
Cocchi
A
A
D000293:Adolescent; D000328:Adult; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000517:prevention & control / Q000523:psychology; D012017:Referral and Consultation / Q000706:statistics & numerical data*; D012569:Schizotypal Personality Disorder / Q000453:epidemiology*; D055815:Young Adult