title: Mapping of T1-values and Gadolinium-concentrations in MRI as indicator of disease activity in luminal Crohn's disease: a feasibility study.
abstract: OBJECTIVE
  To determine the feasibility of T1-mapping and calculation of Gadolinium-values in luminal Crohn's Disease (CD).
  
  
  METHODS
  Nine patients with active CD were included. For each patient disease activity was determined, based on endoscopic and histopathological results. The Crohn's Disease Endoscopic Index of Severity (CDEIS), the Harvey-Bradshaw index (HBI) and C-reactive protein (CRP) were also determined as reference standards. T1-measurements were performed before and after intravenous administration of Gadodiamide in 14 slices in a single breath-hold using the Look-Locker (LL) sequence in combination with a segmented three-dimensional Turbo Field Echo sequence. A Region of Interest (ROI) was drawn around inflamed bowel loops and the mean Gadolinium-concentration within the ROI was calculated. Gadolinium-concentrations were compared between patients with mild and marked disease, as determined by the reference standards.
  
  
  RESULTS
  Mean Gadolinium-concentrations were higher in bowel loops of patients with more active disease, as defined by endoscopic and histopathological examination, CRP, and HBI.
  
  
  CONCLUSIONS
  By using a breath-hold LL sequence in the bowel quantitative assessment of contrast agent concentration is possible, thus permitting objective evaluation of physiological changes in actively inflamed tissue in an area that suffers from motion problems.
authors.affiliation: Department of Radiology, Academic Medical Center, Amsterdam, The Netherlands. k.horsthuis@amc.uva.nl
authors.forename: Karin
authors.initials: K
authors.lastname: Horsthuis
authors.forename: Aart J
authors.initials: AJ
authors.lastname: Nederveen
authors.forename: Marijn-Willem
authors.initials: MW
authors.lastname: de Feiter
authors.forename: Cristina
authors.initials: C
authors.lastname: Lavini
authors.forename: Pieter C F
authors.initials: PC
authors.lastname: Stokkers
authors.forename: Jaap
authors.initials: J
authors.lastname: Stoker
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D003287:Contrast Media / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003424:Crohn Disease / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D003287:Contrast Media; C064925:gadodiamide; D002097:C-Reactive Protein; D019786:Gadolinium DTPA