title: Development of alpha-tocopherol acetate nanoparticles: influence of preparative processes.
abstract: We studied different methods of preparing alpha-tocopherol acetate (ATA) nanoparticles, which are to be used in targeting the lungs as aerosols in order to prevent cigarette smoke toxicity. Poly-(lactide) nanoparticles were prepared using nanoprecipitation and solvent evaporation techniques, which produced, respectively, too small and too large nanoparticles to be aerosolized. The emulsification-diffusion method produced 2 months stable nanoparticles with a size between (500-700 nm). Increasing ATA concentration (1-7 mg/mL) induced a decrease in the association rate (97-93%) and in the adsorbed ATA rate (7-4.5%), which was associated with variations of Zeta potentials (-27.5 to -24.3 mV) and decrease in polymeric wall thickness and density.
authors.affiliation: Pharmacy Department, CHU Henri MONDOR, Creteil, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Anais
authors.forename: N
authors.initials: N
authors.lastname: Razzouq
authors.forename: M
authors.initials: M
authors.lastname: Carvalho
authors.forename: C
authors.initials: C
authors.lastname: Fernandez
authors.forename: A
authors.initials: A
authors.lastname: Astier
authors.forename: M
authors.initials: M
authors.lastname: Paul
authors.forename: A
authors.initials: A
authors.lastname: Astier
authors.forename: H
authors.initials: H
authors.lastname: Fessi
authors.forename: A M
authors.initials: AM
authors.lastname: Lorino
mesh_terms: D000336:Aerosols / Q000737:chemistry; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D004355:Drug Stability; D004655:Emulsions; D008168:Lung / Q000378:metabolism; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D014026:Nicotiana / Q000633:toxicity; D014028:Tobacco Smoke Pollution / Q000517:prevention & control; D024502:alpha-Tocopherol / Q000008:administration & dosage* / Q000737:chemistry* / Q000627:therapeutic use
chemical_list: D000336:Aerosols; D000975:Antioxidants; D004655:Emulsions; D014028:Tobacco Smoke Pollution; D024502:alpha-Tocopherol