title: [First generation antidepressants in the current treatment of depression].
abstract: An aim of the present retrospective (based on medical hystories) study, was to specify the choice of different antidepressants of first generations (AFG) by practical physicians for treatment of different types of depressions. Three hundreds and thirty-four cases (201 female, 133 male) have been studied. The sample included the following types of depression: vital (16 patients), anxious (64), hypochondriac (74), apathic (71), asthenic (13), anesthetic (17), anankastic (19), hysteric (51) and with somatic equivalents (9). It has been found that amitryptiline and imipramine are prescribed in the various depressive states, clomipramine is more often used in anankastic depressions and maprotiline - in anesthetic depressions. When choosing an antidepressant, practical physicians follow the current empiric scheme corresponding to general ideas on the correlation between psychopathological presentations and action of psychotropic drugs on the level of cell metabolism (deficit) of monoamines (dopamine, serotonin, noradrenalin). Moreover, physicians consider clomipramine and maprotiline as more selective antidepressants as they really are; the use of maprotiline is not enough. In conclusion, the author emphasizes the necessity of increasing the knowledge of physicians about possibilities of using AFG taking into account mechanisms of their action.
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Drobizhev
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D003863:Depression / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011594:Psychometrics / Q000379:methods; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents