title: Genetic mapping of the belt pattern in Brown Swiss cattle to BTA3.
abstract: The white belt pattern of Brown Swiss cattle is characterized by a lack of melanocytes in a stretch of skin around the midsection. This pattern is of variable width and sometimes the belt does not fully circle the body. To identify the gene responsible for this colour variation, we performed linkage mapping of the belted locus using six segregating half-sib families including 104 informative meioses for the belted character. The pedigree confirmed a monogenic autosomal dominant inheritance of the belted phenotype in Brown Swiss cattle. We performed a genome scan using 186 microsatellite markers in a subset of 88 animals of the six families. Linkage with the belt phenotype was detected at the telomeric region of BTA3. Fine-mapping and haplotype analysis using 19 additional markers in this region refined the critical region of the belted locus to a 922-kb interval on BTA3. As the corresponding human and mouse chromosome segments contain no obvious candidate gene for this coat colour trait, the mutation causing the belt pattern in the Brown Swiss cattle might help to identify an unknown gene influencing skin pigmentation.
authors.affiliation: Institute of Genetics, Vetsuisse Faculty, University of Berne, Berne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Drögemüller
authors.forename: M
authors.initials: M
authors.lastname: Engensteiner
authors.forename: S
authors.initials: S
authors.lastname: Moser
authors.forename: S
authors.initials: S
authors.lastname: Rieder
authors.forename: T
authors.initials: T
authors.lastname: Leeb
mesh_terms: D000818:Animals; D002417:Cattle / Q000033:anatomy & histology* / Q000235:genetics*; D002874:Chromosome Mapping / Q000662:veterinary; D005260:Female; D005799:Genes, Dominant; D006239:Haplotypes; D006801:Humans; D008297:Male; D051379:Mice; D018895:Microsatellite Repeats; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D012880:Skin Pigmentation / Q000235:genetics*; D013045:Species Specificity