Cytotoxic terpenoids from the fruits of Vitex trifolia L.
Two new labdane-type diterpenoids vitetrifolin H (1) and vitetrifolin I (2), and one new monoterpenoid vitexoid (3), were isolated from the fruits of Vitex trifolia L., together with seven known diterpenoids. Structures of all compounds were elucidated by extensive spectroscopic methods. All these compounds exhibited inhibition of Hela cell proliferation, with IC50 values in the range of 4-28 microM. In addition, vitetrifolin I (2) induced cell cycle G0/G1 phase arrest and apoptosis of Hela cells.
Wu
Jun
J
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China.
Zhou
Tong
T
Zhang
Shu-wei
SW
Zhang
Xiao-hui
XH
Xuan
Li-jiang
LJ
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*; D020950:Vitex / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes