title: The risk factors and outcome of fungal peritonitis in continuous ambulatory peritoneal dialysis patients.
abstract: OBJECTIVE
  To determine the risk factors and outcome of fungal peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 7-year period.
  
  
  METHODS
  This retrospective study was conducted on 30 cases of fungal peritonitis in CAPD patients during a 7-year period (2000-2007). The diagnosis was based on elevated CAPD effluent count and isolation of fungi. Patients were evaluated for previous episode of bacterial peritonitis.
  
  
  RESULTS
  The incidence of fungal peritonitis was 16.2%. Age varied between 8 and 75 years, with a mean age of 57 years. Twenty-three were males (76.7%) and seven were females (23.3%). Seventeen patients (56.6%) had previous episodes of bacterial peritonitis that was treated with multiple antibiotics. The common fungus was Candida species (50%). CAPD catheter removal and initiation of antifungal therapy was done for all patients. Reinsertion was done for three (10%) patients. Mortality rate was 20%.
  
  
  CONCLUSIONS
  Patients with previous bacterial peritonitis and antibiotic usage are at greater risk of developing fungal peritonitis.
authors.affiliation: Department of Nephrology, Sri Ramachandra University, No. 1, Ramachandra Nagar, Porur, Chennai-600 116, Tamil Nadu, India. drindhusrmc@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Indhumathi
authors.forename: V
authors.initials: V
authors.lastname: Chandrasekaran
authors.forename: D
authors.initials: D
authors.lastname: Jagadeswaran
authors.forename: M
authors.initials: M
authors.lastname: Varadarajan
authors.forename: G
authors.initials: G
authors.lastname: Abraham
authors.forename: P
authors.initials: P
authors.lastname: Soundararajan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000935:Antifungal Agents