title: [Molecular biology of preinvasive and invasive breast tumors].
abstract: OBJECTIVE
  To present an overview of molecular characteristics and differences of and between preinvasive and invasive breast tumors.
  
  
  METHODS
  Review.
  
  
  METHODS
  Oncogynecologic center, Clinic of Obstetrics and Gynecology, First Faculty of Medicine, Charles University in Prague and General Teaching Hospital, Prague.
  
  
  METHODS
  Review of literature.
  
  
  CONCLUSIONS
  Identification of genetic and epigenetic changes in preinvasive and invasive breast tumors can help to better classify these lesions and improve and tailor their clinical management. Due to completely different biological behavior of morphologically identical lesions, it is clear that the matter of classification and clarification of their clinical behavior is hidden inside the entire genome or proteome.
authors.affiliation: Onkogynekologické centrum, Gynekologicko-porodnická klinika 1. LF UK a VFN, Praha. michal.zikan@lf1.cuni.cz
authors.forename: M
authors.initials: M
authors.lastname: Zikán
authors.forename: D
authors.initials: D
authors.lastname: Pavlista
authors.forename: Z
authors.initials: Z
authors.lastname: Velenská
authors.forename: D
authors.initials: D
authors.lastname: Cibula
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000235:genetics; D002278:Carcinoma in Situ / Q000737:chemistry* / Q000235:genetics; D018270:Carcinoma, Ductal, Breast / Q000737:chemistry* / Q000235:genetics; D018275:Carcinoma, Lobular / Q000737:chemistry* / Q000235:genetics; D005260:Female; D006801:Humans