title: [Determination of sulfonamides in livestock products and seafoods by liquid chromatography/tandem mass spectrometry using glass bead homogenization].
abstract: A simple and rapid method using liquid chromatography coupled with tandem mass spectrometry (LC/MS/MS) was developed for the determination of 25 kinds of sulfonamides in livestock products and seafoods. The sulfonamides were extracted with acetonitrile by glass bead homogenization and cleaned up with a tandem-connected ODS and basic alumina column. The quantification limits of 25 kinds of sulfonamides were 0.0025-0.005 microg/g. When two sulfonamides of specific samples were excluded, the recoveries and relative standard deviations were 70 to 120% and less than 15%. These results show that the developed method, which minimizes the matrix effect, offers high precision and should be useful for the determination of sulfonamides in livestock products and seafoods.
authors.affiliation: Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Mizuka
authors.initials: M
authors.lastname: Fujita
authors.forename: Shuzo
authors.initials: S
authors.lastname: Taguchi
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Obana
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid; D019411:Clinical Laboratory Techniques; D004531:Eggs / Q000032:analysis*; D008460:Meat / Q000032:analysis*; D008892:Milk / Q000737:chemistry*; D017747:Seafood / Q000032:analysis*; D013449:Sulfonamides / Q000032:analysis*; D053719:Tandem Mass Spectrometry
chemical_list: D013449:Sulfonamides