title: [Effects of Xiaoyao Wan on the behavioral despair and stress depression mice].
abstract: OBJECTIVE
  To investigate the anti-depressant effect and the possible mechanism of Xiaoyao Wan in animal models.
  
  
  METHODS
  The open-field test and the forced swimming test were applied to study the anti-depressant effect of Xiaoyao Wan in mice, and HPLC-ECD was carried out to assay the contents of 5-HT and 5-HIAA, and the mechanism of Xiaoyao Wan on anti-depressant effect was discussed.
  
  
  RESULTS
  Xiaoyao Wan at the dose of 200, 400 and 600 mg/kg significantly increased the revolutions in force swimming test, and ameliorated brain cortex 5-HT and 5-HIAA content of restraint mice. But there was no effect on brain cortex 5-HT and 5-HIAA content of non-restraint mice.
  
  
  CONCLUSIONS
  Xiaoyao Wan has significant anti-depressant effect which may be related to the potentiation of brain serotonergic function.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China. libao0133@163.com
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Lin
authors.initials: L
authors.lastname: Huang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Lin
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
authors.forename: Kurihara
authors.initials: K
authors.lastname: Hiroshi
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005473:Fluoxetine / Q000494:pharmacology / Q000627:therapeutic use; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D012701:Serotonin / Q000378:metabolism; D013550:Swimming
chemical_list: D000928:Antidepressive Agents; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005473:Fluoxetine; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid