title: Resuscitation of preterm infants with reduced oxygen results in less oxidative stress than resuscitation with 100% oxygen.
abstract: The objective of this study was to determine the effects of the level of inhaled oxygen during resuscitation on the levels of free radicals and anti-oxidative capacity in the heparinized venous blood of preterm infants. Forty four preterm infants <35 weeks of gestation with mild to moderate neonatal asphyxia were randomized into two groups. The first group of infants were resuscitated with 100% oxygen (100% O(2) group), while in the other group (reduced O(2) group), the oxygen concentration was titrated according to pulse oximeter readings. We measured total hydroperoxide (TH) and redox potential (RP) in the plasma within 60 min of birth. The integrated excessive oxygen ( summation operator(FiO(2)-0.21) x Time(min)) was higher in the 100% O(2) group than in the reduced O(2) group (p<0.0001). TH was higher in the 100% O(2) group than in the reduced O(2) group (p<0.0001). RP was not different between the 100% O(2) and reduced O(2) groups (p = 0.399). RP/TH ratio was lower in the 100% O(2) group than in the reduced O(2) group (p<0.01). We conclude that in the resuscitation of preterm infants with mild to moderate asphyxia, oxidative stress can be reduced by lowering the inspired oxygen concentration using a pulse oximeter.
authors.affiliation: Division of Neonatal Medicine, Center for Maternal, Fetal and Neonatal Medicine, Saitama Medical Center, Saitama Medical University, 1981 Kamoda-Tujido, Kawagoe, Saitama 350-8550, Japan.
authors.forename: Shoichi
authors.initials: S
authors.lastname: Ezaki
authors.forename: Keiji
authors.initials: K
authors.lastname: Suzuki
authors.forename: Clara
authors.initials: C
authors.lastname: Kurishima
authors.forename: Masumi
authors.initials: M
authors.lastname: Miura
authors.forename: Wan
authors.initials: W
authors.lastname: Weilin
authors.forename: Reiichi
authors.initials: R
authors.lastname: Hoshi
authors.forename: Shizue
authors.initials: S
authors.lastname: Tanitsu
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Tomita
authors.forename: Chikako
authors.initials: C
authors.lastname: Takayama
authors.forename: Masaki
authors.initials: M
authors.lastname: Wada
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Kondo
authors.forename: Masanori
authors.initials: M
authors.lastname: Tamura