[Studies on the anti-tumor activity principles of a marine-derived fungus BZYT-21].
OBJECTIVE
To study the chemical constituents of a marine-derived fungus possessing anti-tumor activity.


METHODS
The compounds were isolated by various chromatographic methods and their structures were elucidated through spectroscopic analysis and chemical and physical properties.


RESULTS
Nine compounds were isolated and identified as: (S)-(-)-N-benzoylphenylalaninol, asperphnamate, cerevisterol, (22E, 24R)-6beta-methnoxyergosta-7,22-diene-3beta, 5alpha-diol, (22E, 24R)-5alpha, 6alpha-epoxy-ergosta-8, 22-diene-3beta, 7alpha-diol, (22E, 24R) -3beta, 5alpha, 9alpha-trihydroxyergosta-7, 22-diene-6-one, (22E, 24R) -3beta-hydroxy-ergosta-5, 8, 22-trien-7-one, ergosterol, ergosterol peroxide.


CONCLUSIONS
(22E, 24R)-3beta-hydroxy-ergosta-5, 8, 22-trien-7-one is isolated from microorganisms for the first time.
Gao
Zong-Hua
ZH
Department of Chemistry, Binzhou Medical Collage, Yantai 264003, China. gzh3308@163.com
Ma
Li-Ying
LY
Shen
Yun-Xiu
YX
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D004875:Ergosterol / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification*; D005658:Fungi / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D015394:Molecular Structure; D025282:Mycelium / Q000737:chemistry; D010840:Phytosterols / Q000737:chemistry / Q000302:isolation & purification
D000470:Alkaloids; D000577:Amides; D000970:Antineoplastic Agents; D010840:Phytosterols; C006954:cerevisterol; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol