title: Bioelectrical impedance phase angle changes during hydration and prognosis in advanced cancer.
abstract: BACKGROUND
  We wished to determine bioelectrical impedance (BIA) correlates before hydration or changes during hydration and determine if these changes were prognostically important.
  
  
  METHODS
  Fifty eligible patients underwent BIA measurements 3 consecutive days. Laboratory studies (electrolytes, creatinine, and hemoglobin) on day 1; weights and vital signs were recorded. Kaplan-Meier survival estimates were made at 30 and 60 days. Hazard ratios (HRs) based on Cox proportional hazards model were calculated.
  
  
  RESULTS
  Weight loss was associated with shorter survival. A higher phase angle (PA) on day 1 predicted longer survival. Increased PA during hydration predicted shorter survival: increased weight during hydration predicted longer survival.
  
  
  CONCLUSIONS
  Higher phase angle before hydration predicts poorer survival and, paradoxically, an increase in phase angle during hydration predicted poorer survival and preexisting intracellular dehydration, cachexia, or poor membrane function.
  
  
  CONCLUSIONS
  Phase angle and weight during hydration predict survival in cancer.
authors.affiliation: Harry R. Horvitz Center for Palliative Medicine, Taussig Cancer Center, Cleveland Clinic, Ohio 44195, USA. davism6@ccf.org
authors.forename: Mellar P
authors.initials: MP
authors.lastname: Davis
authors.forename: Tugba
authors.initials: T
authors.lastname: Yavuzsen
authors.forename: Dilara
authors.initials: D
authors.lastname: Khoshknabi
authors.forename: Jordanka
authors.initials: J
authors.lastname: Kirkova
authors.forename: Declan
authors.initials: D
authors.lastname: Walsh
authors.forename: Wael
authors.initials: W
authors.lastname: Lasheen
authors.forename: Ruth
authors.initials: R
authors.lastname: Lagman
authors.forename: Matthew T
authors.initials: MT
authors.lastname: Karafa
mesh_terms: D001823:Body Composition; D003681:Dehydration / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D017097:Electric Impedance; D045604:Extracellular Fluid; D005260:Female; D006801:Humans; D055103:Hypodermoclysis; D007424:Intracellular Fluid; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009369:Neoplasms / Q000150:complications / Q000175:diagnosis*; D019370:Observation; D011379:Prognosis; D016016:Proportional Hazards Models; D012964:Sodium / Q000378:metabolism; D016019:Survival Analysis; D015431:Weight Loss
chemical_list: D012964:Sodium