title: Capsaicin and arterial hypertensive crisis.
abstract: Chili peppers are rich in capsaicin. The potent vasodilator calcitonin gene-related peptide (CGRP) is stored in a population of C-fiber afferents that are sensitive to capsaicin. CGRP and peptides released from cardiac C fibers have a beneficial effect in myocardial ischemia and reperfusion. It has been reported that capsaicin pretreatment can deplete cardiac C-fiber peptide stores. Furthermore, it has also been reported that capsaicin-treated pigs have significantly increased mean arterial blood pressure compared with controls, and that the decrease in CGRP synthesis and release contributes to the elevated blood pressure. A case has also been reported of an arterial hypertensive crisis in a patient with a large ingestion of peppers and chili peppers the day before. We present a case of an arterial hypertensive crisis in a 19-year-old Italian man with an abundant ingestion of peppers and of chili peppers the preceding day. This case describes an unusual pattern of arterial hypertensive crisis due to capsaicin.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Patanè
authors.forename: Filippo
authors.initials: F
authors.lastname: Marte
authors.forename: Felice Carmelo
authors.initials: FC
authors.lastname: La Rosa
authors.forename: Roberto
authors.initials: R
authors.lastname: La Rocca
mesh_terms: D002211:Capsaicin / Q000506:poisoning*; D002212:Capsicum / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D008297:Male; D055815:Young Adult
chemical_list: D002211:Capsaicin