[Serologic screening for preneoplastic pathology and early stomach cancer].
Cancer of stomach is currently regarded as the final result of a staged multifactor process during which the microenvironment affects cells and causes their changes. One of the main triggering factors is Hp infection. Adenocarcinoma of stomach develops via stages of gastritis, precancerous changes, and cancer. The possibility to prevent cancer ensues from the potential irreversibility of premalignant processes in gastric mucosa, in the first place its atrophy; hence, the importance of its early diagnosis. The state of the endoscopic service in this country is inadequate for mass screening of patients with symptoms of dyspepsia. "GastroPanel", a new serological test for the diagnosis of gastric pathology provides information about histological and functional characteristics of gastric mucosa in the antral and fundal regions of the stomach. The method determines serum gastrin-17, pepsinogen-1, and IgG expressed in response to Hp infection. Our results demonstrate high diagnostic efficiency of "GastroPanel" as a screening technique for atrophic gastritis and assessment of stomach cancer risk.
Maev
I V
IV
Mel'nikova
E V
EV
Kashin
S V
SV
Nadezhin
A S
AS
Kriukova
T V
TV
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000097:blood / Q000453:epidemiology / Q000473:pathology; D016481:Helicobacter Infections / Q000276:immunology* / Q000382:microbiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009367:Neoplasm Staging; D020116:Pepsinogen A / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D013274:Stomach Neoplasms / Q000097:blood* / Q000453:epidemiology / Q000473:pathology*; D055815:Young Adult
D005755:Gastrins; D010446:Peptide Fragments; C013550:gastrin 17; C037980:pepsinogen (1-12); D020116:Pepsinogen A