title: [Heparin-induced thrombocythopenia in a patient with massive pulmonary embolism and dilated cardiomyopathy, successfuly treated with fondaparinux - a case report].
abstract: Heparin-induced thrombocythopenia (HIT) is a potentially serious complication of heparin treatment, rarely observed in cardiological wards. We present a case of a 38-year-old woman with dilated cardiomyopathy and massive pulmonary embolism treated with alteplase and unfractionated heparin. On 12th day an unexpected fall in platelet count was observed, without new signs of thrombosis. The HIT type II was diagnosed. Patient was treated effectively and safely by 7.5 mg of fondaparinux given subcutaneously once daily for 10 days.
authors.affiliation: Uniwersytet Medyczny, ul. Fredry 10, 61-701 Poznań. anowicka@ump.edu.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Nowicka
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kandziora
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Szymanowska
authors.forename: Marek
authors.initials: M
authors.lastname: Michalski
authors.forename: Anna
authors.initials: A
authors.lastname: Piatkowska
authors.forename: Wojciech
authors.initials: W
authors.lastname: Biegalski
authors.forename: Rafał
authors.initials: R
authors.lastname: Dankowski
authors.forename: Kajetan
authors.initials: K
authors.lastname: Poprawski
authors.forename: Michał
authors.initials: M
authors.lastname: Wierzchowiecki
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D002311:Cardiomyopathy, Dilated / Q000150:complications*; D005260:Female; D000077425:Fondaparinux; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D007279:Injections, Subcutaneous; D011134:Polysaccharides / Q000627:therapeutic use*; D011655:Pulmonary Embolism / Q000150:complications / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D011134:Polysaccharides; D006493:Heparin; D000077425:Fondaparinux