title: Is nuclear magnetic resonance lipoprotein subclass related to diabetic retinopathy? The multi-ethnic study of atherosclerosis (MESA).
abstract: OBJECTIVE
  To examine the associations between nuclear magnetic resonance (NMR) defined lipoproteins and diabetic retinopathy (DR) in a population-based sample of adults with type 2 diabetes.
  
  
  METHODS
  In all, 921 persons with diabetes in the Multi-Ethnic Study of Atherosclerosis (MESA) were included. DR was assessed from retinal photographs. Lipoproteins were measured by NMR spectroscopy.
  
  
  RESULTS
  After controlling for age, race/ethnicity, study centre and diabetes and vascular risk factors, no consistent patterns of associations between NMR-defined lipoprotein particle concentrations and subclass with DR were evident.
  
  
  CONCLUSIONS
  The lack of association between NMR-defined lipoproteins and DR does not support clinical use of NMR spectroscopy for management of patients with DR.
authors.affiliation: Centre for Eye Research Australia, University of Melbourne, 32 Gisborne Street, East Melbourne, Victoria 3002, Australia.
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Kreis
authors.forename: Tien Yin
authors.initials: TY
authors.lastname: Wong
authors.forename: F M Amirul
authors.initials: FM
authors.lastname: Islam
authors.forename: Ronald
authors.initials: R
authors.lastname: Klein
authors.forename: Barbara E K
authors.initials: BE
authors.lastname: Klein
authors.forename: Mary Frances
authors.initials: MF
authors.lastname: Cotch
authors.forename: Alicia J
authors.initials: AJ
authors.lastname: Jenkins
authors.forename: Steven
authors.initials: S
authors.lastname: Shea
authors.forename: Jie Jin
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005006:Ethnicity; D006801:Humans; D008074:Lipoproteins / Q000097:blood* / Q000145:classification; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D015203:Reproducibility of Results; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides