Cerebrospinal fluid cytokine levels in migraine, tension-type headache and cervicogenic headache.
Cytokines have been measured in cerebrospinal fluid (CSF) from headache patients [infrequent episodic tension-type headache (TTH) and migraine with or without aura, all during attack, and cervicogenic headache] and compared with levels in pain-free individuals. Both proinflammatory [interleukin (IL)-1beta, tumour necrosis factor-alpha and monocyte chemoattractant protein-1 (MCP-1)] and anti-inflammatory cytokines [IL-1 receptor antagonist (IL-1ra), IL-4, IL-10 and transforming growth factor-beta1 (TGF-beta1)] were included. There were significant group differences in IL-1ra, TGF-beta1 and MCP-1 in episodic TTH and migraine compared with controls, and a significant difference in MCP-1 between cervicogenic headache and migraine with aura. Intrathecal MCP-1 correlated with IL-1ra, IL-10 and TGF-beta1 in episodic TTH, and MCP-1 with IL-10 in migraine with aura. Cytokine increases were modest compared with those often accompanying serious neurological conditions, and may represent a mild response to pain. We believe this to be the first comparative study of CSF cytokine levels in connection with headache.
Bø
S H
SH
Department of Neurology, Akershus University Hospital, Lørenskog, Norway.
Davidsen
E M
EM
Gulbrandsen
P
P
Dietrichs
E
E
Bovim
G
G
Stovner
L J
LJ
White
L R
LR
D000293:Adolescent; D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000134:cerebrospinal fluid; D016207:Cytokines / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000134:cerebrospinal fluid*; D051298:Post-Traumatic Headache / Q000134:cerebrospinal fluid*; D017472:Receptors, Interleukin-1 / Q000032:analysis; D018781:Tension-Type Headache / Q000134:cerebrospinal fluid*; D053773:Transforming Growth Factor beta1 / Q000134:cerebrospinal fluid
D018932:Chemokine CCL2; D016207:Cytokines; D017472:Receptors, Interleukin-1; D053773:Transforming Growth Factor beta1; D016753:Interleukin-10