title: Contact lens wear is associated with decrease of meibomian glands.
abstract: OBJECTIVE
  Approximately 30% to 50% of contact lens (CL) wearers report dry eye symptoms. Meibomian gland dysfunction has been recognized as a possible cause of CL-related dry eye. This study investigated the influence of CL wear on the meibomian glands using a newly developed meibographic technique.
  
  
  METHODS
  Cross-sectional observational case series.
  
  
  METHODS
  Contact lens wearers (n=121; 47 men, 74 women; mean age+/-standard deviation, 31.8+/-8.0 years) and healthy volunteers (n=137; 71 men, 66 women; mean age+/-standard deviation, 31.4+/-15.1 years).
  
  
  METHODS
  The following tests were performed: slit-lamp examinations of the eyelids, corneal and conjunctival staining using fluorescein, measurement of the tear film breakup time, evaluation of the meibomian glands using noncontact meibography, and measurement of tear production using the Schirmer I test. Partial or complete loss of the meibomian glands was scored for each eyelid using 4 grades (meiboscores): grade 0 (no loss of meibomian glands) through grade 3 (the area characterized by gland dropout was more than 66% of the total area containing the meibomian glands). The meiboscores for the upper and lower eyelids were summed for each subject.
  
  
  METHODS
  Score of meibomian gland changes (meiboscore), tear film breakup time, and Schirmer test value.
  
  
  RESULTS
  The meiboscore was significantly higher (P<0.0001) in CL wearers (mean, 1.72; 95% confidence interval, 1.47-1.96) than in the control group (mean, 0.96; 95% confidence interval, 0.73-1.19). The average meiboscore of CL wearers was similar to that of a 60- to 69-year-old age group from the normal population. A significant positive correlation was observed between the duration of CL wear and the meiboscore.
  
  
  CONCLUSIONS
  Contact lens wear is associated with a decrease in the number of functional meibomian glands. This decrease is proportional to the duration of CL wear.
authors.affiliation: Itoh Clinic, Saitama, Japan. ritoh@za2.so-net.ne.jp
authors.forename: Reiko
authors.initials: R
authors.lastname: Arita
authors.forename: Kouzo
authors.initials: K
authors.lastname: Itoh
authors.forename: Kenji
authors.initials: K
authors.lastname: Inoue
authors.forename: Aya
authors.initials: A
authors.lastname: Kuchiba
authors.forename: Takuhiro
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Shiro
authors.initials: S
authors.lastname: Amano
mesh_terms: D000328:Adult; D003261:Contact Lenses / Q000706:statistics & numerical data*; D003430:Cross-Sectional Studies; D003941:Diagnostic Techniques, Ophthalmological; D015352:Dry Eye Syndromes / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008537:Meibomian Glands / Q000503:physiopathology*; D013666:Tears / Q000737:chemistry / Q000502:physiology