Synthesis of epoxides by palladium-catalyzed reactions of tertiary allyl alcohols with aryl or alkenyl halides.
A novel synthetic method for the preparation of tri- or tetrasubstituted epoxides is reported. Treatment of readily available tertiary allyl alcohol with aryl or alkenyl halide under palladium catalysis resulted in arylative cyclization to form the epoxide. The reaction includes intramolecular C-O bond and intermolecular C-C bond construction.
Hayashi
Sayuri
S
Department of Material Chemistry, Graduate School of Engineering, Kyoto University, Kyoto-daigaku Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.
Yorimitsu
Hideki
H
Oshima
Koichiro
K
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D004852:Epoxy Compounds / Q000138:chemical synthesis*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D010165:Palladium; D020005:Propanols / Q000737:chemistry*
D000475:Alkenes; D004852:Epoxy Compounds; D006846:Hydrocarbons, Halogenated; D020005:Propanols; C006463:allyl alcohol; D010165:Palladium