Regional differences in rabbit atrial action potential properties: mechanisms, consequences and pharmacological implications.
Regional differences in electrical action potential (AP) properties can provide a substrate for atrial arrhythmias. We quantify such differences by developing detailed AP models for the left (LA) and right (RA) rabbit atrial cells in order to study the underlying electrophysiological mechanisms, as well as their impacts on vulnerable properties of the atrial tissue. The transient outward current, Ito, is identified as the major factor contributing to the AP differences between the LA and RA cells, which suggests a potential pharmacological target for reducing heterogeneity and vulnerability of the atria.
Aslanidi
Oleg V
OV
School of Physics and Astronomy, University of Manchester, Manchester, M13 9PL, United Kingdom. oleg.aslanidi@manchester.ac.uk
Dewey
Rebecca S
RS
Morgan
Alexandra R
AR
Boyett
Mark R
MR
Zhang
Henggui
H
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D016275:Atrial Function / Q000502:physiology*; D003198:Computer Simulation; D006329:Heart Conduction System / Q000502:physiology*; D015640:Ion Channel Gating / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology*; D011817:Rabbits
D007473:Ion Channels