Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements.
Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has the potential for broad clinical application. We present a simple, compact system using off-axis integrated cavity output spectroscopy with an interband cascade laser and demonstrate its use in real-time measurements of breath ethane. We demonstrate a detection sensitivity of 0.48 ppb/Hz(1/2).
Parameswaran
Krishnan R
KR
Physical Sciences Incorporated, 20 New England Business Center, Andover, Massachusetts 01810, USA. krp@psicorp.com
Rosen
David I
DI
Allen
Mark G
MG
Ganz
Alan M
AM
Risby
Terence H
TH
D001944:Breath Tests / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D004980:Ethane / Q000032:analysis*; D006801:Humans; D007834:Lasers; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods; D018511:Systems Integration
D004980:Ethane