title: Outcomes of surgical intervention for isolated active mitral valve endocarditis.
abstract: OBJECTIVE
  Although several studies have examined the outcomes of mitral valve repair for infective endocarditis, no studies have documented the long-term outcomes of surgical intervention for active endocarditis confined to the mitral valve.
  
  
  METHODS
  One hundred four patients underwent surgical intervention for active infective endocarditis confined to the mitral valve over a 27-year period (mean age, 50 +/- 18 years; 52% female). The infected valve was native in 81 patients, previously repaired 6 patients, and prosthetic in 17 patients. Staphylococcus aureus was the most commonly isolated (32%) source of infection. Twenty-eight (27%) patients had annular abscesses. Surgical intervention consisted of valve repair or replacement for limited infection and radical resection, annular patch reconstruction, and valve replacement for annular abscess. Mean follow-up was 5.6 +/- 4.4 years (range, 0-20 years) and was complete.
  
  
  RESULTS
  There were 9 (8.7%) in-hospital deaths and 28 (27%) late deaths. Overall survival at 5, 7, and 10 years was 73% +/- 5%, 68% +/- 5%, and 58% +/- 6%, respectively. At 7 years, freedom from recurrent endocarditis was 89% +/- 4% and freedom from reoperation was 94% +/- 3%. Event-free survival at 7 and 10 years was 60% +/- 6% and 46% +/- 7%, respectively, and was significantly higher in patients with native endocarditis versus those with nonnative endocarditis (ie, prosthetic or previously repaired; 7 years: 63% +/- 7% vs 50% +/- 12%, P < .005). Preoperative shock, S aureus infection, and bioprosthesis insertion were independent predictors of death from all causes. The patients in the bioprosthesis group were older (57 +/- 20 years vs 44 +/- 15 years in the mechanical group and 46 +/- 12 years in the repair group, P = .003).
  
  
  CONCLUSIONS
  Surgical intervention for isolated active mitral valve endocarditis remains difficult, with high morbidity and mortality in the long term. Event-free survival is worse in those who have nonnative mitral valve endocarditis.
authors.affiliation: Peter Munk Cardiac Centre, Toronto General Hospital, Toronto, Ontario, Canada.
authors.forename: Amir M
authors.initials: AM
authors.lastname: Sheikh
authors.forename: Abdelsalam M
authors.initials: AM
authors.lastname: Elhenawy
authors.forename: Manjula
authors.initials: M
authors.lastname: Maganti
authors.forename: Susan
authors.initials: S
authors.lastname: Armstrong
authors.forename: Tirone E
authors.initials: TE
authors.lastname: David
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Feindel
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D004697:Endocarditis, Bacterial / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011183:Postoperative Complications / Q000453:epidemiology; D016896:Treatment Outcome