title: Twelve-year analysis of severe cases of drug reaction with eosinophilia and systemic symptoms: a cause of unpredictable multiorgan failure.
abstract: BACKGROUND
  Factors implicated in the severity of drug reaction with eosinophilia and systemic symptoms (DRESS) have not been identified. We retrospectively describe and analyze severe cases of DRESS defined by history of intensive care unit admission and death due to DRESS.
  
  
  METHODS
  Of 15 patients retrospectively recruited in France, 14 were admitted to the intensive care unit and 3 died. The culprit drugs were already known to cause or trigger DRESS: allopurinol, minocycline hydrochloride, anticonvulsants, sulfonamides, and antibiotics. Visceral involvement with severe manifestations responsible for intensive care unit admission or death was variable and often multiple (pneumonitis, hepatitis, renal failure, encephalitis, hemophagocytosis, cardiac failure, and pancytopenia) and resulted in multiorgan failure in 11 patients. These severe complications sometimes developed late in DRESS. Human herpesvirus 6 infection was demonstrated in 6 of 7 patients. In addition, human herpesvirus 6 infection was demonstrated in involved viscera in 2 patients.
  
  
  CONCLUSIONS
  Severe DRESS is rare. Some specificities of visceral involvement were associated with allopurinol and minocycline. However, visceral involvement comprising multiorgan failure seemed to be unpredictable. Better knowledge of DRESS is necessary to propose specific and prompt treatment. Early demonstration of human herpesvirus 6 reactivation could be considered a prognostic factor for identifying patients at higher risk and, hence, needs to be evaluated.
authors.affiliation: Department of Dermatology, Bichat-Claude Bernard Hospital, Assistance Publique des Hôpitaux de Paris, 46 rue Henri Huchard, 75018 Paris, France.
authors.forename: Majed
authors.initials: M
authors.lastname: Eshki
authors.forename: Laurence
authors.initials: L
authors.lastname: Allanore
authors.forename: Philippe
authors.initials: P
authors.lastname: Musette
authors.forename: Brigitte
authors.initials: B
authors.lastname: Milpied
authors.forename: Anne
authors.initials: A
authors.lastname: Grange
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Guillaume
authors.forename: Olivier
authors.initials: O
authors.lastname: Chosidow
authors.forename: Isabelle
authors.initials: I
authors.lastname: Guillot
authors.forename: Valérie
authors.initials: V
authors.lastname: Paradis
authors.forename: Pascal
authors.initials: P
authors.lastname: Joly
authors.forename: Béatrice
authors.initials: B
authors.lastname: Crickx
authors.forename: Sylvie
authors.initials: S
authors.lastname: Ranger-Rogez
authors.forename: Vincent
authors.initials: V
authors.lastname: Descamps
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D004342:Drug Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D004802:Eosinophilia / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology*