CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses.
Previous studies have implicated CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers. A number of studies have been devoted to the association of CYP1A1 or GSTM1 polymorphism with susceptibility to oral carcinoma and have yielded conflicting results. The aim of the present study was to assess the possible associations of oral cancer risk with CYP1A1 genetic variation and GSTM1 null genotype respectively via systematic meta-analyses. The data suggest that variant genotypes of CYP1A1 might not be risk factors for oral cancer, whereas GSTM1 null genotype significantly increases susceptibility to oral cancer in Asians but not Caucasians.
Zhuo
Wenlei
W
Institute of Cancer, Chongqing, China.
Wang
Yan
Y
Zhuo
Xianlu
X
Zhu
Yi
Y
Wang
Weidong
W
Zhu
Bo
B
Li
Dezhi
D
Chen
Zhengtang
Z
D044466:Asian People; D016022:Case-Control Studies; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D019317:Evidence-Based Medicine; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics* / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase