title: Gamma-oryzanol-loaded calcium pectinate microparticles reinforced with chitosan: optimization and release characteristics.
abstract: Response surface methodology was used to optimize microparticle preparation conditions, including the ratio of pectin:gamma-oryzanol (OZ) (X(1)), agitation speed (X(2)), and the concentration of emulsifier (X(3)), for maximal entrapment efficiency (EE) of OZ-loaded Ca pectinate microparticles. The optimized values of X(1), X(2), and X(3) were found to be 2.72:5.28, 1143.5 rpm, and 2.61%, respectively. Experimental results obtained for the optimum formulation agreed favorably with the predicted results, indicating the usefulness of predicting models for EE. In order to evaluate the effect of chitosan-coating and blending on the release pattern of the entrapped OZ from microparticles, chitosan-coated and blended Ca pectinate microparticles were prepared. Release studies revealed that the chitosan treatments, especially the chitosan-coating, were effective in suppressing the release in both simulated gastric fluid (SGF) and intestinal fluid (SIF).
authors.affiliation: Department of Food and Nutrition, Hanyang University, Seongdong-gu, Seoul, Republic of Korea.
authors.forename: Ji-Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyeon Gyu
authors.initials: HG
authors.lastname: Lee
mesh_terms: D002118:Calcium / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D016503:Drug Delivery Systems; D005753:Gastric Mucosa / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D015233:Models, Statistical; D010316:Particle Size; D010368:Pectins / Q000737:chemistry*; D010666:Phenylpropionates / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D010666:Phenylpropionates; D010368:Pectins; D048271:Chitosan; C013172:gamma-oryzanol; D002118:Calcium