A new approach to reconstruction of central aortic blood pressure using 'adaptive' transfer function.
This paper presents a new system identification approach to the reconstruction of central aortic blood pressure signal by exploiting a non-invasive peripheral blood pressure measurement. This technique, which is called the 'adaptive' transfer function, is able to reconstruct the aortic blood pressure signal by characterizing the aortic-to-peripheral cardiovascular dynamics solely based on the peripheral measurement. In contrast to the previous related efforts, it does not require any a priori knowledge on the empirical and/or population-based relationship, e.g. the predetermined or generalized transfer function, as well as multiple peripheral measurements. The initial proof-of-principle on the efficacy of the adaptive transfer function is demonstrated by the experimental results from human and animal subjects.
Hahn
Jin-Oh
JO
Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. stardust@mit.edu
Asada
H Harry
HH
Reisner
Andrew T
AT
Jaffer
Farouc A
FA
D000465:Algorithms; D000818:Animals; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D001795:Blood Pressure Determination / Q000379:methods*; D003198:Computer Simulation; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008955:Models, Cardiovascular; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine