Heterologous expression systems for polyketide synthases.
Polyketide synthases are the main biochemical machinery for the production of a structurally diverse group of natural products, polyketides. Their heterologous expression enables overproduction of target compounds, generation of novel analogs, and provides a basic understanding of their reaction programs. This Highlight outlines the current state of heterologous expression of type I, type II, and type III polyketide synthases of microbial and plant origins.
Fujii
Isao
I
School of Pharmacy, Iwate Medical University, 2-1-1 Nishitokuta, Yahaba, Iwate 028-3694, Japan. ifujii@iwate-med.ac.jp
D001419:Bacteria / Q000235:genetics / Q000378:metabolism; D001688:Biological Products / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D015394:Molecular Structure; D010944:Plants / Q000235:genetics / Q000378:metabolism; D048630:Polyketide Synthases / Q000145:classification / Q000235:genetics / Q000378:metabolism
D001688:Biological Products; D048630:Polyketide Synthases