title: Effect of bromfenac ophthalmic solution on ocular inflammation following cataract surgery.
abstract: OBJECTIVE
  This study compared the post-cataract surgery anti-inflammatory effects of topical treatment with 0.1% bromfenac, 0.1% betamethasone or both on postoperative anterior chamber inflammation and corneal swelling.
  
  
  METHODS
  Seventy-two patients with no eye disease other than cataract were enrolled in a prospective, randomized study to undergo phacoemulsification combined with intraocular lens implantation. After cataract surgery, patients were randomized to treatment with bromfenac, betamethasone or both agents. Twenty-five eyes were assigned to bromfenac, 23 to betamethasone and 24 to the combined treatment group. Inflammatory reactions in the anterior chamber were measured with laser flare photometry preoperatively and at 1 and 3 days, 1 and 2 weeks, and 1 and 2 months postoperatively. Intraocular pressure (IOP) and corneal thickness were measured at the same time-points. Best corrected visual acuity (BCVA) was measured preoperatively and at 2 days, 1 and 2 weeks, and 1 and 2 months postoperatively. Specular microscope endothelial photography of the central region of the cornea was performed preoperatively and at 3 months after surgery.
  
  
  RESULTS
  There were no significant differences among the bromfenac, betamethasone and combined treatment groups in BCVA, IOP, aqueous flare or corneal thickness. Cystoid macular oedema was present in one eye treated with betamethasone.
  
  
  CONCLUSIONS
  There were no significant differences in anti-inflammatory effects among the three treatments. These findings suggest that bromfenac is as effective as betamethasone in minimizing inflammatory reactions after cataract surgery.
authors.affiliation: Department of Ophthalmology, Miyata Eye Hospital, Miyakonojo, Miyazaki, Japan. miyanaga@miyata-med.ne.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Miyanaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyai
authors.forename: Ryohei
authors.initials: R
authors.lastname: Nejima
authors.forename: Yoko
authors.initials: Y
authors.lastname: Maruyama
authors.forename: Kazunori
authors.initials: K
authors.lastname: Miyata
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kato
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects; D001082:Aqueous Humor / Q000187:drug effects; D001577:Benzophenones / Q000008:administration & dosage* / Q000009:adverse effects; D001623:Betamethasone / Q000008:administration & dosage / Q000009:adverse effects; D001969:Bromobenzenes / Q000008:administration & dosage* / Q000009:adverse effects; D002387:Cataract Extraction / Q000009:adverse effects*; D003315:Cornea / Q000473:pathology; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D004728:Endothelium, Corneal / Q000473:pathology; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D019654:Lens Implantation, Intraocular; D008269:Macular Edema / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011184:Postoperative Period; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001577:Benzophenones; D001969:Bromobenzenes; D009883:Ophthalmic Solutions; C053083:bromfenac; D001623:Betamethasone