The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology.
Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.
Ambrosio
Fabrisia
F
Department of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Kadi
Fawzi
F
Lexell
Jan
J
Fitzgerald
G Kelley
GK
Boninger
Michael L
ML
Huard
Johnny
J
D000375:Aging / Q000502:physiology; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D019417:Hindlimb Suspension; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D020388:Muscular Dystrophy, Duchenne / Q000503:physiopathology; D012038:Regeneration / Q000502:physiology*; D012106:Research; D032496:Satellite Cells, Skeletal Muscle / Q000166:cytology / Q000502:physiology*
D007334:Insulin-Like Growth Factor I