title: [Medicamentous test for the screening of pharmacogenic risk of aminoglycoside ototoxicity].
abstract: The primary objective of this work was to assess the informative value (sensitivity and specificity) of the diagnostic screening of subjects at high risk of aminoglycoside ototoxicity. The method is based on the vegetative resonance test. It is argued that this test meets the requirements to diagnostic screening procedures and allows for the evaluation of susceptibility to aminoglycosides from such phenotypic trait as responsiveness to resonance between oscillations of aminoglycosides and elongated cells in neuroepithelium of the acoustic analyzer. Sensitivity and specificity of the test was estimated to be 87 and 94% respectively using the "nerve and cochlear duct" organopreparation and the parameter of "acquired toxic information".
authors.forename: M G
authors.initials: MG
authors.lastname: Abakarov
authors.forename: M M
authors.initials: MM
authors.lastname: Magomedov
authors.forename: Iu B
authors.initials: IuB
authors.lastname: Belousov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Gotovskiĭ
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000617:Aminoglycosides / Q000009:adverse effects*; D001301:Audiometry, Pure-Tone; D004252:DNA Mutational Analysis; D003937:Diagnosis, Differential; D015870:Gene Expression / Q000235:genetics; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D017354:Point Mutation / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000617:Aminoglycosides