In vivo photosensitizer tomography inside the human prostate.
Interstitial photodynamic therapy (IPDT) provides a promising means to treat large cancerous tumors and solid organs inside the human body. The treatment outcome is dependent on the distributions of light, photosensitizer, and tissue oxygenation. We present a scheme for reconstructing the spatial distribution of a fluorescent photosensitizer. The reconstruction is based on measurements performed in the human prostate, acquired during an ongoing IPDT clinical trial, as well as in optical phantoms. We show that in an experimental setup we can quantitatively reconstruct a fluorescent inclusion in a fluorescent background. We also show reconstructions from a patient showing a heterogeneous distribution of the photosensitizer mTHPC in the human prostate.
Axelsson
Johan
J
Department of Physics, Lund University, Lund, Sweden. johan.axelsson@fysik.lth.se
Swartling
Johannes
J
Andersson-Engels
Stefan
S
D000970:Antineoplastic Agents; D003287:Contrast Media; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008652:Mesoporphyrins / Q000627:therapeutic use*; D008856:Microscopy, Fluorescence / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014054:Tomography / Q000379:methods*
D000970:Antineoplastic Agents; D003287:Contrast Media; D008652:Mesoporphyrins; D017319:Photosensitizing Agents; C072269:temoporfin