A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery.
A novel temperature-sensitive liposomal MRI contrast agent has been developed, which allows drug carrier localization using (1)H CEST with simultaneous quantification of the drug release using (19)F MR imaging in response to a local temperature increase.
Langereis
Sander
S
Philips Research Europe, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands. sander.langereis@philips.com
Keupp
Jochen
J
van Velthoven
Juliën L J
JL
de Roos
Inge H C
IH
Burdinski
Dirk
D
Pikkemaat
Jeroen A
JA
Grüll
Holger
H
D003287:Contrast Media / Q000032:analysis* / Q000737:chemistry*; D016503:Drug Delivery Systems; D005461:Fluorine / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011522:Protons; D012680:Sensitivity and Specificity; D013053:Spectrophotometry; D013696:Temperature
D003287:Contrast Media; D008081:Liposomes; D011522:Protons; D005461:Fluorine