SAT-1 -1415T/C polymorphism and susceptibility to schizophrenia.
Patients suffering from psychosis show increased blood and fibroblast total polyamine levels. Spermidine/spermine N1-acetyltransferase (SSAT-1) and its coding gene (SAT-1) are the main factors regulating polyamine catabolism. The aim of the present study was to examine the association between the SAT-1 -1415T/C single nucleotide polymorphism (SNP) and schizophrenia. A case-control design was used in order to compare the genotypes for the SNP between schizophrenia patients (n=180, 83 females and 97 males), other non-psychotic psychiatric patients (n=413, 256 females and 157 males), and healthy controls (n=251, 101 females and 150 males). No significant differences in the distribution of the genotypes of the SAT-1 -1415T/C SNP were found groups among groups. We failed to demonstrate a significant association between the SAT-1 -1415T/C SNP and schizophrenia, but a mild association between allele C and psychopathology was found in the female group.
Bermudo-Soriano
Carlos Riaza
CR
Department of Psychiatry, Ramón y Cajal Hospital, Madrid, Spain. setebotalacanica@msn.com
Vaquero-Lorenzo
Concepcion
C
Diaz-Hernandez
Montserrat
M
Perez-Rodriguez
M Mercedes
MM
Fernandez-Piqueras
Jose
J
Saiz-Ruiz
Jeronimo
J
Baca-Garcia
Enrique
E
D000123:Acetyltransferases / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012306:Risk; D012559:Schizophrenia / Q000453:epidemiology / Q000235:genetics*; D013030:Spain / Q000453:epidemiology; D000099228:Diamine N-Acetyltransferase
D000123:Acetyltransferases; D000099228:Diamine N-Acetyltransferase