title: Silent recovery of native kidney function after transplantation in a patient with membranous nephropathy.
abstract: Recurrence of membranous nephropathy (MN) is frequently seen after transplantation. However, there are no published data about the course of MN in the native kidneys after transplantation. Disease progression in almost all cases is assumed to be the 'natural' course after transplantation. We report on a patient suffering from end-stage renal disease due to MN. Eight years after transplantation, nephrectomy was performed due to chronic rejection and unexpectedly, partial recovery of native kidney function was noted. As far as we know, there is no other similar case reported in the literature. The potential impact of the immunosuppression, especially of calcineurin inhibitors, is discussed.
authors.affiliation: Clinic for Transplantation Immunology and Nephrology, University Hospital, Petersgraben 4, 4031 Basel, Switzerland.
authors.forename: Bernard
authors.initials: B
authors.lastname: Descoeudres
authors.forename: Olivier
authors.initials: O
authors.lastname: Giannini
authors.forename: Markus
authors.initials: M
authors.lastname: Aschwanden
authors.forename: Thomas
authors.initials: T
authors.lastname: Eugster
authors.forename: Helmut
authors.initials: H
authors.lastname: Hopfer
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mihatsch
authors.forename: Juerg
authors.initials: J
authors.lastname: Steiger
authors.forename: Michael
authors.initials: M
authors.lastname: Mayr
mesh_terms: D002648:Child; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000601:surgery*; D006084:Graft Rejection / Q000601:surgery; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000601:surgery; D016030:Kidney Transplantation; D009392:Nephrectomy; D011184:Postoperative Period; D020127:Recovery of Function
chemical_list: D007166:Immunosuppressive Agents