Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population.
OBJECTIVE
Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study, we investigated whether SNPs in this gene were associated with T1D in the Han Chinese population.


METHODS
In this case-controlled association study, a total of 205 T1D patients and 422 non-diabetic subjects of the Han Chinese population were enrolled. Two SNPs, namely, rs17802927 and rs725613, in the KIAA0350 gene were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) protocol.


RESULTS
The intron SNP rs725613 was strongly associated with T1D in the Han Chinese population [P = 0.00007, odds ratio (OR) = 0.527, 95% confidence interval (CI) = 0.383-0.726], and the frequencies of its genotypes in the T1D group significantly differed from those in the control group (P = 0.0001).


CONCLUSIONS
The intron polymorphism rs725613 in the KIAA0350 gene is associated with susceptibility to T1D, and this association is not race specific.
Wu
Xiaopan
X
National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing, People's Republic of China.
Zhu
Xilin
X
Wang
Xin
X
Ma
Juan
J
Zhu
Shuying
S
Li
Jingyun
J
Liu
Ying
Y
D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D003922:Diabetes Mellitus, Type 1 / Q000208:ethnology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007438:Introns; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009004:Monosaccharide Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
C522505:CLEC16A protein, human; D037181:Lectins, C-Type; D009004:Monosaccharide Transport Proteins