title: Metal-ion selectivity of chemically modified uracil pairs in DNA duplexes.
abstract: DNA duplexes containing 5-modified uracil pairs (5-bromo, 5-fluoro, and 5-cyanouracil) bind selectivity to metal ions. Their selectivity is sensitive to the pH value of the solution (see picture), as the acidities of the modified uracil bases vary according to the electron-withdrawing properties of the substituents.
authors.affiliation: Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama, Kanagawa 221-8686, Japan.
authors.forename: Itaru
authors.initials: I
authors.lastname: Okamoto
authors.forename: Kenji
authors.initials: K
authors.lastname: Iwamoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yoko
authors.initials: Y
authors.lastname: Miyake
authors.forename: Akira
authors.initials: A
authors.lastname: Ono
mesh_terms: D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D044366:Transition Temperature; D014498:Uracil / Q000737:chemistry*
chemical_list: D007477:Ions; D008670:Metals; D014498:Uracil; D004247:DNA