Antifungal activity of Glycyrrhiza glabra extracts and its active constituent glabridin.
Glabridin, an active constituent of Glycyrrhiza glabra roots, was found to be active against both yeast and filamentous fungi. Glabridin also showed resistance modifying activity against drug resistant mutants of Candida albicans at a minimum inhibitory concentration of 31.25-250 microg/mL. Although the compound was reported earlier to be active against Candida albicans, but this is the first report of its activity against drug resistant mutants.
Fatima
Atiya
A
Genetic Resources and Biotechnology Division, Central Institute of Medicinal and Aromatic Plants (CSIR), Kukrail Picnic Spot Road, P. O. CIMAP, Lucknow 226015, India.
Gupta
Vivek K
VK
Luqman
Suaib
S
Negi
Arvind S
AS
Kumar
J K
JK
Shanker
Karuna
K
Saikia
Dharmendra
D
Srivastava
Suchita
S
Darokar
M P
MP
Khanuja
Suman P S
SP
D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D006035:Glycyrrhiza / Q000737:chemistry*; D007529:Isoflavones / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology
D000935:Antifungal Agents; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; C107601:glabridin