title: Bayesian hierarchical functional data analysis via contaminated informative priors.
abstract: A variety of flexible approaches have been proposed for functional data analysis, allowing both the mean curve and the distribution about the mean to be unknown. Such methods are most useful when there is limited prior information. Motivated by applications to modeling of temperature curves in the menstrual cycle, this article proposes a flexible approach for incorporating prior information in semiparametric Bayesian analyses of hierarchical functional data. The proposed approach is based on specifying the distribution of functions as a mixture of a parametric hierarchical model and a nonparametric contamination. The parametric component is chosen based on prior knowledge, while the contamination is characterized as a functional Dirichlet process. In the motivating application, the contamination component allows unanticipated curve shapes in unhealthy menstrual cycles. Methods are developed for posterior computation, and the approach is applied to data from a European fecundability study.
authors.affiliation: Department of Statistical Sciences, University of Padua, 241 Padua, Italy. scarpa@stat.unipd.it
authors.forename: Bruno
authors.initials: B
authors.lastname: Scarpa
authors.forename: David B
authors.initials: DB
authors.lastname: Dunson
mesh_terms: D016477:Artifacts; D001499:Bayes Theorem; D001699:Biometry / Q000379:methods*; D002986:Clinical Trials as Topic; D016000:Cluster Analysis; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D015987:Effect Modifier, Epidemiologic; D015233:Models, Statistical; D016016:Proportional Hazards Models