Neuro2A differentiation by Galphai/o pathway.
Signaling from G(i/o)-coupled G protein-coupled receptors (GPCRs), such as the serotonin 1B, cannabinoid 1, and dopamine D2 receptors, inhibits cAMP production by adenylyl cyclases and activates protein kinases, such as Src, mitogen-activated protein kinases 1 and 2, and Akt. Activation of these protein kinases results in stimulation of neurite outgrowth in the central nervous system (CNS) and in neuronal cell lines. This Connections Map traces downstream signaling pathways from G(i/o)-coupled GPCRs to key protein kinases and key transcription factors involved in neuronal differentiation. Components in the Science Signaling Connections Map are linked to Nature Molecule Pages. This interoperability provides ready access to detail that includes information about specific states for the nodes.
Ma'ayan
Avi
A
Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA. avi.maayan@mssm.edu
Jenkins
Sherry L
SL
Barash
Alexander
A
Iyengar
Ravi
R
D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D020558:GTP Phosphohydrolases / Q000737:chemistry; D019206:GTP-Binding Protein alpha Subunits, Gi-Go / Q000378:metabolism*; D020935:MAP Kinase Signaling System; D051379:Mice; D008954:Models, Biological; D008959:Models, Neurological; D016501:Neurites / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D015398:Signal Transduction; D018631:ras Proteins / Q000378:metabolism
D043562:Receptors, G-Protein-Coupled; D020558:GTP Phosphohydrolases; D019206:GTP-Binding Protein alpha Subunits, Gi-Go; D018631:ras Proteins