Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression.
In order to investigate whether physical exercise during development would promote changes the calcium-binding protein parvalbumin (PV) expression in the hippocampal formation, we performed an immunostaining study after an aerobic exercise program in rats during adolescent period of life. Wistar rats were submitted to daily exercise program in a treadmill between postnatal day 21 and 60. Running time and speed were gradually increased during the subsequent days until 18m/min for 60min. After the aerobic exercise program, animals of all groups were killed and PV immunostaining procedures were performed. The results showed significant increase of protein level in the hippocampal formation and PV-immunoreactive neurons in CA1 and CA2/CA3 regions of rats submitted to exercise when compared with control rats. This finding indicates that aerobic exercise program during adolescent period promotes neuroplastic changes in hippocampal formation.
Gomes da Silva
Sérgio
S
Department of Physiology, Universidade Federal de São Paulo, Brazil.
Doná
Flávia
F
da Silva Fernandes
Maria José
MJ
Scorza
Fulvio Alexandre
FA
Cavalheiro
Esper Abrão
EA
Arida
Ricardo Mario
RM
D000293:Adolescent / Q000502:physiology*; D000818:Animals; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D006801:Humans; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D010320:Parvalbumins / Q000378:metabolism*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
D010320:Parvalbumins