[Influence of Qianlie Antong tablets on expresstion of VEGF and bFGF in protatic tissues of BHP rats].
OBJECTIVE
To evaluate the effect of Qianlie Antong tablet (QLAT) on the tissues of benign prostatic hyperplasia (BPH) of experimental rats, and seek its mechanism.


METHODS
The animal model of BPH was made with rats by subcutaneously injecting methylacetic acid testosterone after emasculated. The changes of prostatic tissues of every group are studied with morphometry combining the immunohistochemistry method, the expression of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in prostate tissue were examine.


RESULTS
QLAT can diminish the gland weight, volume and index of prostate, compared with control group, and also can decrease average area and circumference of gland, and increase the amount of total glands in equal area. Meanwhile, the expression of bFGF and VEGF in prostatic tissues were decreased in GANT groups, compared with control group.


CONCLUSIONS
QLAT can diminish the prostate gland volume, which may be attained by inhibiting the expression of VEGF and bFGF in prostatic tissue.
Xu
Bin
B
Pharmacy Dept., Ruijin Hospital, Affiliated to Medical College of Shanghai Jiaotong University, Shanghai 200025, China. ceogift@gmail.com
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D011467:Prostate / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D042461:Vascular Endothelial Growth Factor A; C532631:qianlieantong; D016222:Fibroblast Growth Factor 2