New chiral derivatizing agents: convenient determination of absolute configurations of free amino acids by 1H NMR.
The chiral carbonate reagents 5 allow for the direct and unambiguous determination of the absolute configurations of a wide range of free amino acids using (1)H NMR. By using a approximately 3:1 mixture of (S)-5 and (R)-5, absolute configurations of the corresponding carbamates are determined by only analyzing the nitrogen protons.
Kurosu
Michio
M
Department of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523-1682, USA. michio.kurosu@colostate.edu
Li
Kai
K
D000588:Amines / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013237:Stereoisomerism
D000588:Amines; D000596:Amino Acids; D002219:Carbamates