Genetic thrombophilia variants and risk for preeclampsia among American Indians.
OBJECTIVE
To determine the prevalence of thrombophilic genetic variants in an American Indian population and determine if they are associated with preeclampsia.


METHODS
A total of 87 cases, 165 controls and an additional 75 population-based controls were genotyped for two thrombophilic polymorphisms.


RESULTS
The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin variants in this population was 2.1% and 0.5% respectively. No statistically significant associations between these genetic variants and preeclampsia were found.


CONCLUSIONS
The prevalence of thrombophilic variants is of possible public health significance for other morbidity; but perhaps not in relation to preeclampsia.
Best
Lyle G
LG
Turtle Mountain Community College, Belcourt, North Dakota, USA. sbest@utma.com
Dorsam
Sheri T
ST
Nadeau
Melanie
M
Burd
Larry
L
Anderson
Cindy M
CM
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D011225:Pre-Eclampsia / Q000208:ethnology / Q000235:genetics*; D011247:Pregnancy; D011446:Prospective Studies; D011516:Prothrombin / Q000235:genetics; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000235:genetics*; D055815:Young Adult
C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin