Interpolyelectrolyte complexes between starlike and linear macromolecules: a structural model for nonviral gene vectors.
Molecular dynamics simulations are used to probe the structural organization of nonstoichiometric interpolyelectrolyte complexes (IPECs) formed by oppositely charged starlike and linear polyelectrolytes (PEs) in dilute aqueous solution. We demonstrate that undercompensated star-IPEC consists of a denser coacervate core and a charged starlike corona. Two distinctive populations of star branches completely embedded in a coacervate core and stretched in a lyophilizing corona are found. The scaling arguments support the stability of IPEC with partitioned star branches.
Larin
Sergey V
SV
Institute of Macromolecular Compounds, Russian Academy of Sciences, 199004 St. Petersburg, Russia.
Darinskii
Anatoly A
AA
Zhulina
Ekaterina B
EB
Borisov
Oleg V
OV
D003198:Computer Simulation; D004279:DNA, Viral / Q000235:genetics; D004573:Electrolytes / Q000737:chemistry*; D005822:Genetic Vectors / Q000235:genetics*; D008954:Models, Biological; D008958:Models, Molecular; D008968:Molecular Conformation
D004279:DNA, Viral; D004573:Electrolytes