Sarcoidosis presenting with severe hypocalcaemia.
Disorders of calcium metabolism, especially hypercalcemia and hypercalceuria, are common in sarcoidosis. They are caused by extra renal unsuppressed production of 1,25 dihydroxy vitamin D at the level of the sarcoid granuloma. Hormonal changes during pregnancy have a physiological synergistic effect on this mechanism, which is primarily parathyroid hormone (PTH) dependant. However, the combination of primary hypoparathyroidism with hypocalcemia and sarcoidosis is rare. Di George syndrome, is a dysmorphic disorder characterised by aplasia/hypoplasia of thymus and parathyroid glands in addition to aortic arch anamolies and facial dysmorphia. After commencing appropriate treatment this lady made excellent recovary.
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Department of Rheumatology, Mid Western Regional Hospital, Dooradoyle, Limerick, Ireland. modelian@gmail.com
Khan
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Irwin
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Fraser
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D000328:Adult; D002118:Calcium / Q000627:therapeutic use; D004062:DiGeorge Syndrome / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology; D008206:Lymphatic Diseases / Q000150:complications*; D049590:Postpartum Period; D012507:Sarcoidosis / Q000150:complications* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use
D013256:Steroids; D014807:Vitamin D; D002118:Calcium