title: Imaging patterns of brain injury in term-birth asphyxia.
abstract: OBJECTIVE
  To develop an extended asphyxia-score based on cerebral ultrasound (US) and MRI in order to gain further insight into the pathophysiology of asphyxia.
  
  
  METHODS
  First week cerebral US and MRI of 80 asphyxiated term infants were scored according to a new scoring system based on separate grading of injury to deep grey matter and to (sub)cortical/white matter. Our findings were compared with published scoring systems.
  
  
  RESULTS
  Six patterns of brain injury were derived: deep grey matter injury with either limited or extensive cortical involvement, damage to deep grey matter with watershed injury, isolated watershed injury, isolated white matter injury (leukomalacia) and isolated cortical necrosis. The mortality rate was considerable in patterns with extensive cortical injury.
  
  
  CONCLUSIONS
  Six patterns of brain injury, following term-birth asphyxia were found using a new imaging score.
authors.affiliation: Department of Paediatrics, Division of Neonatology, Erasmus MC-Sophia, Rotterdam, The Netherlands. r.swarte@erasmusmc.nl
authors.forename: Renate
authors.initials: R
authors.lastname: Swarte
authors.forename: Maarten
authors.initials: M
authors.lastname: Lequin
authors.forename: Perumpillichira
authors.initials: P
authors.lastname: Cherian
authors.forename: Alexandra
authors.initials: A
authors.lastname: Zecic
authors.forename: Johannes
authors.initials: J
authors.lastname: van Goudoever
authors.forename: Paul
authors.initials: P
authors.lastname: Govaert
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D001930:Brain Injuries / Q000209:etiology / Q000473:pathology*; D054022:Cerebrum / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D004453:Echoencephalography; D006801:Humans; D007231:Infant, Newborn; D047929:Term Birth