[Retinoic acid-inducible gene-I-like receptors and RNA virus recognition--a review].
Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) have recently been identified as cytoplasmic sensors for RNA viruses. The RLR signaling cascades induce the production of type I interferons and pro-inflammatory cytokines, which are rigorously regulated by the host. On other side, RNA viruses have evolved strategies to evade RLR signaling. In this review, we present our current understanding of RLR signaling in RNA virus recognition and antiviral innate immunity.
Qin
Chengfeng
C
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing 100071, China. cfqin@hotmail.com
Qin
Ede
E
D000818:Animals; D006801:Humans; D012327:RNA Virus Infections / Q000276:immunology / Q000821:virology*; D012328:RNA Viruses / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014212:Tretinoin / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
D014764:Viral Proteins; D014212:Tretinoin