title: [Ultrasound elastography of ethanol-induced hepatic lesions].
abstract: OBJECTIVE
  To study the value of ultrasound elastography in the evaluation of ethanol-induced lesions of liver.
  
  
  METHODS
  Alcohol with a dose of 2 ml was injected into a fresh porcine liver under ultrasound guidance to create stiff necrosis. Then freehand elastography of the lesion from the identical scan plane was obtained with Siemens SONOLINE Antares system using VF10-5 probe at about every 30 seconds till 6 minutes later. The original high-quality radio-frequency data were acquired through an ultrasound research interface provided by the ultrasound system. Corresponding elastograms were then produced offline using cross-corre-lation technique and compared with gross specimen.
  
  
  RESULTS
  A hyperechoic area with acoustic shadow below appeared immediately after alcohol injection. The hyperechoic area diffused and its boundary was illegible following injection. On the contrary, the ethanol-induced lesion in elastography appeared as a low strain hard region surrounded by high-strain soft hepatic tissues with clear but irregular boundaries. Sequential elastograms with the lesion boundaries sketched showed that the lesion area grew in the first 3 minutes after ethanol injection and then reached a plateau, which corresponded to the gross specimen.
  
  
  CONCLUSIONS
  Ultrasound elastography can be used to detect and evaluate the diffusion of ethanol-induced hepatic lesion.
authors.affiliation: Department of Diagnostic Ultrasound, Peking University Third Hospital, Beijing 100083, China.
authors.forename: Li-Gang
authors.initials: LG
authors.lastname: Cui
authors.forename: Jin-Hua
authors.initials: JH
authors.lastname: Shao
authors.forename: Jin-Rui
authors.initials: JR
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
authors.forename: Yi-Zhuo
authors.initials: YZ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D054459:Elasticity Imaging Techniques / Q000379:methods*; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000473:pathology; D013552:Swine
chemical_list: D000431:Ethanol