title: Synthesis of a sialic acid containing complex-type N-glycan on a solid support.
abstract: A new solid-phase synthesis of N-linked glycans featuring 1) highly stereoselective beta-mannosylation and microfluidic alpha-sialylation and 2) efficient glycosylation of the N-phenyltrifluoroacetimidate units on JandaJel resin is reported. Reagent concentration effects by a fluorous solvent are effectively applied, and the use of these methods results in the first synthesis of a sialic acid containing complex-type N-glycan on a solid support.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka University, 1-1 Machikaneyama-cho, Toyonaka-shi, Osaka 560-0043, Japan.
authors.forename: Katsunori
authors.initials: K
authors.lastname: Tanaka
authors.forename: Yohei
authors.initials: Y
authors.lastname: Fujii
authors.forename: Hiroomi
authors.initials: H
authors.lastname: Tokimoto
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Mori
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Tanaka
authors.forename: Guang-ming
authors.initials: GM
authors.lastname: Bao
authors.forename: Eric R O
authors.initials: ER
authors.lastname: Siwu
authors.forename: Aiko
authors.initials: A
authors.lastname: Nakayabu
authors.forename: Koichi
authors.initials: K
authors.lastname: Fukase
mesh_terms: D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D019158:N-Acetylneuraminic Acid / Q000737:chemistry*; D011134:Polysaccharides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011134:Polysaccharides; D019158:N-Acetylneuraminic Acid