Metal-ion selectivity of chemically modified uracil pairs in DNA duplexes.
DNA duplexes containing 5-modified uracil pairs (5-bromo, 5-fluoro, and 5-cyanouracil) bind selectivity to metal ions. Their selectivity is sensitive to the pH value of the solution (see picture), as the acidities of the modified uracil bases vary according to the electron-withdrawing properties of the substituents.
Okamoto
Itaru
I
Department of Material and Life Chemistry, Faculty of Engineering, Kanagawa University, 3-27-1 Rokkakubashi, Kanagawa-ku, Yokohama, Kanagawa 221-8686, Japan.
Iwamoto
Kenji
K
Watanabe
Yuko
Y
Miyake
Yoko
Y
Ono
Akira
A
D004247:DNA / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry*; D008670:Metals / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D044366:Transition Temperature; D014498:Uracil / Q000737:chemistry*
D007477:Ions; D008670:Metals; D014498:Uracil; D004247:DNA