title: Segmentation of arterial vessel wall motion to sub-pixel resolution using M-mode ultrasound.
abstract: We describe a method for segmenting arterial vessel wall motion to sub-pixel resolution, using the returns from M-mode ultrasound. The technique involves measuring the spatial offset between all pairs of scans from their cross-correlation, converting the spatial offsets to relative wall motion through a global optimization, and finally translating from relative to absolute wall motion by interpolation over the M-mode image. The resulting detailed wall distension waveform has the potential to enhance existing vascular biomarkers, such as strain and compliance, as well as enable new ones.
authors.affiliation: Merck Research Labs, Rahway, NJ, USA.
authors.forename: Craig
authors.initials: C
authors.lastname: Fancourt
authors.forename: Karim
authors.initials: K
authors.lastname: Azer
authors.forename: Sharmilee L
authors.initials: SL
authors.lastname: Ramcharan
authors.forename: Michelle
authors.initials: M
authors.lastname: Bunzel
authors.forename: Barry R
authors.initials: BR
authors.lastname: Cambell
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Sachs
authors.forename: Matthew
authors.initials: M
authors.lastname: Walker
mesh_terms: D000465:Algorithms; D000818:Animals; D001158:Arteries / Q000473:pathology*; D001499:Bayes Theorem; D015415:Biomarkers / Q000378:metabolism*; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D015233:Models, Statistical; D011846:Radio Waves; D051381:Rats; D012984:Software; D013314:Stress, Mechanical; D013997:Time Factors; D014463:Ultrasonography / Q000379:methods*
chemical_list: D015415:Biomarkers