Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men.
BACKGROUND
The effect of bariatric surgery on the reproductive function of obese men is not entirely elucidated.


OBJECTIVE
The aim of the study was to define the effect of Roux-En-Y gastric bypass surgery on the reproductive hormones and sexual function in obese men.


METHODS
The cohort was followed for 2 yr at a clinical research center.


METHODS
Sixty-four severely obese men (22 who had gastric bypass surgery and 42 controls) participated in the study.


METHODS
Anthropometrics [weight, body mass index (BMI), and percentage body fat] and reproductive hormones were measured. The sexual quality of life was assessed using the Impact of Weight on the Quality Of Life-Lite questionnaire.


METHODS
Reproductive hormones and sexual quality of life were measured.


RESULTS
The mean age was 48.9 +/- 1.2 yr. At baseline, mean weight was 333.0 +/- 7.1 lb, BMI was 46.2 +/- 0.9 kg/m(2), and total testosterone was 339.9 +/- 21.32 ng/dl. BMI correlated positively with estradiol and negatively with total and free testosterone. Indices of dissatisfaction with sexual quality of life correlated positively with measures of obesity. Difficult sexual performance and low sexual desire correlated negatively with free and total testosterone (r = -0.273, P = 0.038; and r = -0.267, P = 0.042, respectively). After 2 yr, the gastric bypass surgery group had a significant decrease in BMI (-16.6 +/- 1.2 vs. -0.46 +/- 0.51 kg/m(2)) and estradiol (-8.1 +/- 2.4 vs. 1.6 +/- 1.4 pg/ml) and had an increase in total testosterone (310.8 +/- 47.6 vs. 14.2 +/- 15.3 ng/dl) and free testosterone (45.2 +/- 5.1 vs. -0.4 +/- 3.0 pg/ml). Sexual quality of life was improved after gastric bypass surgery.


CONCLUSIONS
Hormonal alterations and diminished sexual quality of life among obese men are related to degree of obesity, and both are improved after gastric bypass surgery.
Hammoud
Ahmad
A
Division of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, Utah 84132, USA. Ahmad.hammoud@hsc.utah.edu
Gibson
Mark
M
Hunt
Steven C
SC
Adams
Ted D
TD
Carrell
Douglass T
DT
Kolotkin
Ronette L
RL
Meikle
A Wayne
AW
D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000523:psychology* / Q000706:statistics & numerical data*; D006801:Humans; D007989:Libido; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D010549:Personal Satisfaction; D012725:Sexual Behavior; D013739:Testosterone / Q000097:blood; D015431:Weight Loss
D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002097:C-Reactive Protein