[Acute necrotizing tubulointerstitial nephritis due to adenoviral infection following hematopoietic stem cell transplantation: clinical findings obtained from 4 autopsy cases].
Once adenovirus infection extends to the kidney from the bladder in the immunosuppressive state after hematopoietic stem cell transplantation, most patients develop acute renal failure due to adenovirus-associated necrotizing tubulointerstitial nephritis. In the 6 years from 2000 to 2006, we retrospectively investigated the characteristics of adenovirus infection in 402 patients who had received a hematopoietic stem cell transplantation in our hospital. The incidence of adenovirus-associated hemorrhagic cystitis in patients who had received a hematopoietic stem cell transplantation was 3.5% (14/402). Among these 14 patients, 4 developed acute necrotizing tubulointerstitial nephritis all of whom died, which yielded the incidence and mortality rates of the disease of 1.0% and 100%, respectively. Once adenovirus infection extends to major organs in a rapid manner, the patient's general condition becomes fatal. Further study is necessary to establish the diagnosis and treatment of adenoviral infections in a compromised host.
Nakamura
Yuya
Y
Department of Nephrology, Tokyo Metropolitan Komagome General Hospital, Tokyo, Japan.
Ohashi
Kazuteru
K
Nakano
Natsuko
N
Nemoto
Tetsuo
T
Funada
Nobuaki
N
Ando
Minoru
M
D000208:Acute Disease; D000257:Adenoviridae Infections; D000328:Adult; D000368:Aged; D001344:Autopsy; D003556:Cystitis / Q000821:virology; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007673:Kidney Cortex Necrosis / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000473:pathology / Q000821:virology*