title: Model predictive control of depth of anaesthesia: guidelines for controller configuration.
abstract: The paper presents a feasibility study on the use of Model based Predictive control (MPC) to regulate the level of Depth of Anaesthesia (DoA) when measured by the BIS index. Pharmacokinetic/pharmacodynamic nonlinear models of DoA when Propofol and Remifentanil are used as hypnotic and analgesic drugs are linearized around the desired working point for DoA in order to obtain a linear state-space model coupled with an extra integrator to include integral action in the control. This state-space model is then used in a MPC algorithm. The main contribution of the paper consists in the characterization of the influence of the different design parameters in the MPC performance when controlling DoA.
authors.affiliation: INESC-ID, R. Alves Redol 9, 1000-029 Lisboa, Portugal. cardoso.nicolas@gmail.com
authors.forename: N
authors.initials: N
authors.lastname: Cardoso
authors.forename: J M
authors.initials: JM
authors.lastname: Lemos
mesh_terms: D000465:Algorithms; D000758:Anesthesia / Q000379:methods*; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004360:Drug Therapy, Computer-Assisted / Q000379:methods* / Q000592:standards*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D008954:Models, Biological; D017410:Practice Guidelines as Topic
chemical_list: D006993:Hypnotics and Sedatives