HS071, a new furan-type cytotoxic metabolite from Streptomyces sp. HS-HY-071.
Investigation of the bioactive metabolites from the soil-derived actinomycete, Streptomyces sp. HS-HY-071, a new furan-type antibiotic, HS071 (1), was isolated. Its structure was established as methyl 4-hydroxymethyl-2-pentylfuran-3-carboxylate on the basis of extensive 1D and 2D NMR and MS spectral analysis. It exhibited in vitro activity against HCT-116 cell with an IC50 of 18.2 microg/ml.
Wang
Jidong
J
Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou, Zhejiang, China.
Zhang
Hui
H
Yang
Xiaohu
X
Zhou
Yue
Y
Wang
Haibin
H
Bai
Hua
H
D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002681:China; D003110:Colonic Neoplasms / Q000188:drug therapy; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012988:Soil Microbiology; D013237:Stereoisomerism; D013302:Streptomyces / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D005663:Furans; C539434:methyl 4-hydroxymethyl-2-pentylfuran-3-carboxylate