title: [A case-crossover study on air pollutants and the mortality of stroke].
abstract: OBJECTIVE
  To investigate the short-term effect of particulate matter in air on the mortality of stroke.
  
  
  METHODS
  Using time-stratified case-crossover study design, an association was examined between stroke mortality and particulate matter with aerodynamic diameter of < 10 microm (PM10) of 2002 - 2004 in Hangzhou city. Meanwhile, the acute health effect of other gaseous pollutants (sulfur dioxide, SO2 and nitrogen dioxide, NO2) was also analyzed.
  
  
  RESULTS
  A total of 9906 deaths of stroke were included. The crude stroke mortality was 83.54 per 100 000. After being adjusted for meteorological factors, when an increase of 10 microg/m3 in PM10, SO2 and NO2 in three days was noticed, it appeared that the increases of mortality of stroke were 0.56% (95% CI: 0.14%-0.99%), 1.62% (95% CI: 0.26% - 3.01%) and 2.07% (95% CI: 0.54% - 3.62%) respectively. There was no distinct association in multi-pollutant models. In sensitivity analysis, the associations were found in all single-pollutant models but not statistically significant in multi-pollutant models after replacing the missing values.
  
  
  CONCLUSIONS
  It is suggested that the short-term elevation in PM10 as well as SO2 and NO2 daily concentrations were related to the increase of stroke mortality in Hangzhou city.
authors.affiliation: Hangzhou Center for Disease Control and Prevention, Hangzhou 310006, China.
authors.forename: Yan-Jun
authors.initials: YJ
authors.lastname: Ren
authors.forename: Xiu-Yang
authors.initials: XY
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Chen
authors.forename: Qing-Min
authors.initials: QM
authors.lastname: Liu
authors.forename: Hai-Qing
authors.initials: HQ
authors.lastname: Xiang
authors.forename: Da-Feng
authors.initials: DF
authors.lastname: Jin
authors.forename: Ren-Hua
authors.initials: RH
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000032:analysis*; D002423:Cause of Death; D002681:China / Q000453:epidemiology; D018592:Cross-Over Studies; D004784:Environmental Monitoring; D062665:Epidemiological Monitoring; D005260:Female; D006801:Humans; D008962:Models, Theoretical; D009585:Nitrogen Dioxide / Q000032:analysis; D052638:Particulate Matter / Q000032:analysis*; D020521:Stroke / Q000453:epidemiology / Q000401:mortality*; D013458:Sulfur Dioxide / Q000032:analysis; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D052638:Particulate Matter; D013458:Sulfur Dioxide; D009585:Nitrogen Dioxide