Increased -1 ribosomal frameshifting efficiency by yeast prion-like phenotype [PSI+].
Programmed -1 ribosomal frameshifting (-1RF) is usually regulated by a slippery sequence and an RNA secondary structure but can be affected by the slippery sequence combined with translational perturbation. Dramatic increases of -1RF efficiencies arise from the slippery sequences in [PSI+], an epigenetic modifier of translation termination fidelity. Curing of [PSI+] abolished such increases of -1RF efficiency. Enhanced -1RF frequency at the slippery sequences could be another physiological effect induced directly or indirectly by the perturbation of the translation process in [PSI+] cells.
Park
Hee Jung
HJ
Department of Chemistry, School of Natural Sciences, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Park
So Jung
SJ
Oh
Doo-Byoung
DB
Lee
Sangho
S
Kim
Yang-Gyun
YG
D001483:Base Sequence; D018965:Frameshifting, Ribosomal / Q000235:genetics*; D017930:Genes, Reporter; D005822:Genetic Vectors; D019791:Guanidine / Q000494:pharmacology; D049409:Luciferases, Firefly / Q000235:genetics / Q000378:metabolism; D049410:Luciferases, Renilla / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D010957:Plasmids; D011328:Prions / Q000235:genetics*; D014176:Protein Biosynthesis; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics*
D011328:Prions; D011993:Recombinant Fusion Proteins; D049410:Luciferases, Renilla; D049409:Luciferases, Firefly; D019791:Guanidine