The new analogues of nitrogen mustard with one, two or three 2-chloroethylamino fragments. Reactions with nucleophiles.
1,3,5-Triazines substituted with mono-, di, and tri-[4-(2-chloroethyl)piperazin-l-yl] groups gave products of substitution of chlorine atom when treated with ethanol, phenol, butylamine, toluidine,or thiophenol under mild reaction conditions.
Kolesińska
Beata
B
Institute of Organic Chemistry, Technical University of Łódź, 116 Zeromskiego St., 90-924 Łódź, Poland. beata.kolesinska@p.lodz.pl
Drozdowska
Danuta
D
Kamiński
Zbigniew J
ZJ
D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis*; D008466:Mechlorethamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D014227:Triazines / Q000138:chemical synthesis* / Q000737:chemistry
D018906:Antineoplastic Agents, Alkylating; D014227:Triazines; D008466:Mechlorethamine