A review of the application of lipid-based systems in systemic, dermal/ transdermal, and ocular drug delivery.
The introduction of combinatorial chemistry and the development of high-throughput techniques has significantly increased the amount of new active lipophilic molecular entities. As a result, the need for successful delivery of these lipophilic active compounds has also increased. One such method of delivery is through the use of advanced lipid-based drug delivery systems. Traditionally, the majority of reviews of lipid-based drug delivery systems were based on the oral administration field only. This review article focuses on the use of lipids in parenteral, dermal/ transdermal, and ocular drug delivery systems. Specific needs, considerations, approaches, and limitations in lipid-based drug delivery are discussed herein on the basis of the anatomical and physiological diversity of the target organs and systems.
Gershkovich
Pavel
P
Division of Pharmaceutics and Biopharmaceutics, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3. pgershko@interchange.ubc.ca
Wasan
Kishor M
KM
Barta
Cheri A
CA
D004333:Drug Administration Routes; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry; D013678:Technology, Pharmaceutical
D004655:Emulsions; D008055:Lipids; D008081:Liposomes; D008823:Micelles