title: Zinc therapy for diarrhoea improves growth among Bangladeshi infants 6 to 11 months of age.
abstract: OBJECTIVE
  We assessed the effect of zinc for the treatment of diarrhoea implemented at the community level on physical growth among children 6 to 35 months of age.
  
  
  METHODS
  The service areas of 30 community health workers in the Matlab field site of International Centre for Diarrhoeal Disease Research, Bangladesh, were randomly allocated to the intervention or comparison study arm. Between November 1998 and October 2000, caretakers of 3- to 59-month-old children with diarrhoea in both intervention and comparison areas were offered oral rehydration solution and feeding advice, and severe episodes were referred for facility-based care. The caretakers of the children in the intervention area were additionally offered 20 mg/day elemental zinc for 14 days as adjunct treatment for each diarrhoea episode. Weight and length of children who were 6 to 11 months of age at the beginning of the study were measured every 2 months for 2 years. Rates of length and weight gains were compared between children living in intervention and control arms using a latent growth model.
  
  
  RESULTS
  Characteristics of children living in control and intervention areas were similar, except that more children living in intervention areas were underweight at baseline (44 vs 35%; P = 0.02). Children living in intervention clusters gained slightly more weight and length than children in the control clusters (86.4 g/year and 2.8 mm/year, respectively).
  
  
  CONCLUSIONS
  The therapeutic use of zinc along with oral rehydration solution for community-based diarrhoea management may have a small positive benefit on the rates of growth among children younger than 3 years of age.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Mohakhali, Bangladesh.
authors.forename: Aliya
authors.initials: A
authors.lastname: Naheed
authors.forename: Christa L
authors.initials: CL
authors.lastname: Walker Fischer
authors.forename: Dinesh
authors.initials: D
authors.lastname: Mondal
authors.forename: Saifuddin
authors.initials: S
authors.lastname: Ahmed
authors.forename: Shams El
authors.initials: SE
authors.lastname: Arifeen
authors.forename: Mohammad
authors.initials: M
authors.lastname: Yunus
authors.forename: Robert E
authors.initials: RE
authors.lastname: Black
authors.forename: Abdullah H
authors.initials: AH
authors.lastname: Baqui
mesh_terms: D001459:Bangladesh; D001827:Body Height; D003153:Community Health Services; D003967:Diarrhea / Q000188:drug therapy*; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007223:Infant; D008297:Male; D011446:Prospective Studies; D015430:Weight Gain; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D015032:Zinc