Rubiacordone A: a new anthraquinone glycoside from the roots of Rubia cordifolia.
A new anthraquinone, Rubiacordone A (1) (6-acetoxy-1-hydroxy-2-methylanthraquinone-3-O-alpha-L-rhamnopyranoside), was isolated together with the known anthraquinone, 1-acetoxy-6-hydroxy-2-methylanthraquinone-3-O-[alpha-L-rhamnopyranosyl-(1-->2)-beta-D-glucopyranoside] (2), from the dried roots of Rubia cordifolia. Their structures were elucidated on the basis of extensive 1D and 2D-NMR, as well as HRESI-MS spectroscopic analysis. Metabolites 1 and 2 showed considerable antimicrobial activity against Gram-positive bacteria.
Li
Xiang
X
College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun, PR China. drxiang@hotmail.com
Liu
Zhi
Z
Chen
Yun
Y
Wang
Li-Juan
LJ
Zheng
Yi-Nan
YN
Sun
Guang-Zhi
GZ
Ruan
Chang-Chun
CC
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008516:Medicine, Chinese Traditional; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D045470:Rubia / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000880:Anthraquinones; D000890:Anti-Infective Agents; D004365:Drugs, Chinese Herbal; D006027:Glycosides; D010936:Plant Extracts