Porous biodegradable scaffold: predetermined porosity by dissolution of poly(ester-anhydride) fibers from polyester matrix.
A novel selective leaching method for the porogenization of the biodegradable scaffolds was developed. Continuous, predetermined pore structure was prepared by dissolving fast eroding poly(epsilon-caprolactone)-based poly(ester-anhydride) fibers from the photo-crosslinked poly(epsilon-caprolactone) matrix. The porogen fibers dissolved in the phosphate buffer (pH 7.4, 37 degrees C) within a week, resulting in the porosity that replicated exactly the single fiber dimensions and the overall arrangement of the fibers. The amount of the porosity, estimated with micro-CT, corresponded with the initial amount of the fibers. The potential to include bioactive agents in the porogen fibers was demonstrated with the bioactive glass.
Rich
Jaana
J
Polymer Technology, Department of Biotechnology and Chemical Technology, Helsinki University of Technology, P.O. Box 6100, 02015 TKK, Espoo, Finland. jaana.rich@tkk.fi
Korhonen
Harri
H
Hakala
Risto
R
Korventausta
Joni
J
Elomaa
Laura
L
Seppälä
Jukka
J
D020341:Absorbable Implants; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*
D011091:Polyesters