Iron-catalyzed ligand-free three-component coupling reactions of aldehydes, terminal alkynes, and amines.
A tri-umph in many respects: The iron-catalyzed ligand-free, one-pot three-component coupling reactions of aldehydes, terminal alkynes, and amines in the presence of 4 A molecular sieves yields the corresponding propargylamines in good to excellent yields, displays a broad substrate scope, and is economical and environmentally friendly (see scheme).
Li
Pinhua
P
Department of Chemistry, Huaibei Coal Teachers College, Huaibei, Anhui 235000, China.
Zhang
Yicheng
Y
Wang
Lei
L