title: Chlamydia pneumoniae DNA is present in peripheral blood mononuclear cells during acute coronary syndrome and correlates with chlamydial lipopolysaccharide levels in serum.
abstract: Chlamydia pneumoniae can possibly trigger and maintain inflammation in coronary arteries. Chlamydia pneumoniae DNA and chlamydial lipopolysaccharide (cLPS) were measured 3 times during a 1-y period in 97 patients with acute coronary syndrome. Chlamydia pneumoniae DNA in peripheral blood mononuclear cells was detected in 8 (8.2%) patients at the initial hospitalization and in 9 (10.6%) patients at 3 months. One y after the acute coronary syndrome, Chlamydia pneumoniae DNA was not found in any patients. Serum cLPS levels were elevated at inclusion, and declined significantly during follow-up (1.40 microg/ml; (0.20-2.91), median; (range of 25th to 75th percentiles) at inclusion, 0.44 microg/ml; (0.00-1.39) at 1 y; ANOVA p<0.0001). cLPS levels correlated significantly to Chlamydia pneumoniae DNA positivity at 3 months (p=0.003). In conclusion, Chlamydia pneumoniae DNA is present during acute coronary syndrome and in the recovery period, but declines in stable state, suggesting a role of the bacterium in the acute phase of coronary syndrome.
authors.affiliation: Department of Medicine, Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
authors.forename: Anil
authors.initials: A
authors.lastname: Palikhe
authors.forename: Terttu
authors.initials: T
authors.lastname: Tiirola
authors.forename: Mirja
authors.initials: M
authors.lastname: Puolakkainen
authors.forename: Markku S
authors.initials: MS
authors.lastname: Nieminen
authors.forename: Pekka
authors.initials: P
authors.lastname: Saikku
authors.forename: Maija
authors.initials: M
authors.lastname: Leinonen
authors.forename: Juha
authors.initials: J
authors.lastname: Sinisalo
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000382:microbiology*; D000368:Aged; D016009:Chi-Square Distribution; D023521:Chlamydophila Infections / Q000150:complications / Q000453:epidemiology / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000097:blood*; D005260:Female; D005387:Finland; D006761:Hospitals; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000382:microbiology*; D008070:Lipopolysaccharides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D018709:Statistics, Nonparametric
chemical_list: D004269:DNA, Bacterial; D008070:Lipopolysaccharides