Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938.
Two new aromatic alkaloids, designated citrinamides A and B, were isolated from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis, including NMR and amino acid analysis. Citrinamides A and B showed moderate potentiation of miconazole activity against Candida albicans.
Fukuda
Takashi
T
Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
Hasegawa
Yoko
Y
Sakabe
Yasunari
Y
Tomoda
Hiroshi
H
Omura
Satoshi
S
D000813:Anilides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D004357:Drug Synergism; D005285:Fermentation; D005973:Glutamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology*; D010407:Penicillium / Q000378:metabolism*
D000813:Anilides; D000935:Antifungal Agents; C535079:citrinamide A; C535080:citrinamide B; D005973:Glutamine; D008825:Miconazole