title: Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia.
abstract: OBJECTIVE
  To assess whether supplementation with Coenzyme Q10 (CoQ10) during pregnancy reduces the risk of pre-eclampsia.
  
  
  METHODS
  Women at increased risk of pre-eclampsia were enrolled in a randomized, double-blind, placebo-controlled trial. Women were assigned to receive 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. The primary outcome was rate of pre-eclampsia. Statistical analyses were by intention-to-treat.
  
  
  RESULTS
  Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed-up. The overall rate of pre-eclampsia was 20% (n=47). Thirty women (25.6%) in the placebo group developed pre-eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant (P=0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33-0.96).
  
  
  CONCLUSIONS
  Supplementation with CoQ10 reduces the risk of developing pre-eclampsia in women at risk for the condition.
authors.affiliation: Experimental Pharmacology and Cellular Metabolism Unit, Biomedical Center, Central University of Ecuador, Quito, Ecuador. eteran@cbm.uce.edu.ec
authors.forename: Enrique
authors.initials: E
authors.lastname: Teran
authors.forename: Isabel
authors.initials: I
authors.lastname: Hernandez
authors.forename: Belen
authors.initials: B
authors.lastname: Nieto
authors.forename: Rosio
authors.initials: R
authors.lastname: Tavara
authors.forename: Juan Emilio
authors.initials: JE
authors.lastname: Ocampo
authors.forename: Andres
authors.initials: A
authors.lastname: Calle
mesh_terms: D000293:Adolescent; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D012307:Risk Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10