title: The association of red blood cell counts with endothelin-1 in African and Caucasian women.
abstract: The literature shows an increase in endothelin-1 with increased levels of erythrocytes. There are also indications that inflammation and elevated endothelin-1 levels interact with erythropoiesis. In this study, the association of erythrocytes and endothelin-1 in women of different ethnicities was investigated. Blood pressure, vascular resistance, and C-reactive protein (P = 0.09) were significantly higher in the African women (n = 102) compared to the Caucasian women (n = 115), while arterial compliance was significantly lower in the African women with no significant differences for endothelin-1. In single, partial, and multiple regression analyses, there was a significant positive correlation between the red blood cell count and log endothelin-1 in the Caucasians while in the Africans there was a weak negative correlation. This is an indication that endothelin-1 might interfere with erythrocyte production in Africans with higher levels of inflammation.
authors.affiliation: Subject Group Physiology, North-West University, Private Bag, Potchefstroom, South Africa. Hugo.Huisman@nwu.ac.za
authors.forename: Hugo W
authors.initials: HW
authors.lastname: Huisman
authors.forename: Aletta E
authors.initials: AE
authors.lastname: Schutte
authors.forename: Johannes M
authors.initials: JM
authors.lastname: van Rooyen
authors.forename: Rudolph
authors.initials: R
authors.lastname: Schutte
authors.forename: Leoné
authors.initials: L
authors.lastname: Malan
authors.forename: Catatharina M T
authors.initials: CM
authors.lastname: Fourie
authors.forename: Nicolass T
authors.initials: NT
authors.lastname: Malan
mesh_terms: D000328:Adult; D044383:Black People; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D019332:Endothelin-1 / Q000097:blood*; D004906:Erythrocyte Count; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D013019:South Africa; D014655:Vascular Resistance; D044465:White People
chemical_list: D019332:Endothelin-1; D002097:C-Reactive Protein