title: The impact of wall shear stress and pressure drop on the stability of the atherosclerotic plaque.
abstract: Rupture of vulnerable atheromatous plaque in the carotid and coronary arteries often leads to stroke and heart attack respectively. The mechanism of blood flow and plaque rupture in stenotic arteries is still not fully understood. A three dimensional rigid wall model was solved under steady state conditions and unsteady conditions by assuming a time-varying inlet velocity profile to investigate the relative importance of axial forces and pressure drops in arteries with asymmetric stenosis. Flow-structure interactions were investigated for the same geometry and the results were compared with those retrieved with the corresponding 2D cross-section structural models. The Navier-Stokes equations were used as the governing equations for the fluid. The tube wall was assumed hyperelastic, homogeneous, isotropic and incompressible. The analysis showed that the three dimensional behavior of velocity, pressure and wall shear stress is in general very different from that predicted by cross-section models. Pressure drop across the stenosis was found to be much higher than shear stress. Therefore, pressure may be the more important mechanical trigger for plaque rupture other than shear stress, although shear stress is closely related to plaque formation and progression.
authors.affiliation: Departments of Radiology and Engineering, University of Cambridge and Addenbrooke¿s Hospital, CB2 0QQ, UK.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Li
authors.forename: Valentina
authors.initials: V
authors.lastname: Taviani
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: Gillard
mesh_terms: D050197:Atherosclerosis / Q000473:pathology*; D001783:Blood Flow Velocity; D002339:Carotid Arteries / Q000473:pathology; D016893:Carotid Stenosis / Q000473:pathology; D003198:Computer Simulation; D004548:Elasticity; D008955:Models, Cardiovascular; D033081:Shear Strength; D013314:Stress, Mechanical