title: Management of familial hypertriglyceridemia during pregnancy with plasma exchange.
abstract: Hypertriglyceridemia-induced pancreatitis is a serious complication of familial dyslipidemias. Hormonal influences during pregnancy can compromise otherwise controlled lipid levels in women with familial hypertriglyceridemia and predispose to pancreatitis leading to increased morbidity in both mother and fetus. We report the successful use of therapeutic plasma exchange (TPE) in the management of hypertriglyceridemia during pregnancy resulting in avoidance of pancreatitis and delivery of a healthy term infant. Thirteen TPEs were performed from 19 to 36 weeks gestation to maintain tight control of triglyceride levels.
authors.affiliation: Division of Transfusion Medicine, Pathology and Lab Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. Praveen.Sivakumaran@cshs.org
authors.forename: Praveen
authors.initials: P
authors.lastname: Sivakumaran
authors.forename: Steven W
authors.initials: SW
authors.lastname: Tabak
authors.forename: Kimberly
authors.initials: K
authors.lastname: Gregory
authors.forename: Samuel H
authors.initials: SH
authors.lastname: Pepkowitz
authors.forename: Ellen B
authors.initials: EB
authors.lastname: Klapper
mesh_terms: D000328:Adult; D019468:Disease Management; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D008052:Lipid Metabolism, Inborn Errors / Q000188:drug therapy*; D010195:Pancreatitis / Q000517:prevention & control; D010951:Plasma Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy