title: Determination of absorbed dose in water at the reference point d(r0, theta0) for an 192Ir HDR brachytherapy source using a Fricke system.
abstract: A ring-shaped Fricke device was developed to measure the absolute dose on the transverse bisector of a 192Ir high dose rate (HDR) source at 1 cm from its center in water, D(r0, theta0). It consists of a polymethylmethacrylate (PMMA) rod (axial axis) with a cylindrical cavity at its center to insert the 192Ir radioactive source. A ring cavity around the source with 1.5 mm thickness and 5 mm height is centered at 1 cm from the central axis of the source. This ring cavity is etched in a disk shaped base with 2.65 cm diameter and 0.90 cm thickness. The cavity has a wall around it 0.25 cm thick. This ring is filled with Fricke solution, sealed, and the whole assembly is immersed in water during irradiations. The device takes advantage of the cylindrical geometry to measure D(r0, theta0). Irradiations were performed with a Nucletron microselectron HDR unit loaded with an 192Ir Alpha Omega radioactive source. A Spectronic 1001 spectrophotometer was used to measure the optical absorbance using a 1 mL quartz cuvette with 1.00 cm light pathlength. The PENELOPE Monte Carlo code (MC) was utilized to simulate the Fricke device and the 192Ir Alpha Omega source in detail to calculate the perturbation introduced by the PMMA material. A NIST traceable calibrated well type ionization chamber was used to determine the air-kerma strength, and a published dose-rate constant was used to determine the dose rate at the reference point. The time to deliver 30.00 Gy to the reference point was calculated. This absorbed dose was then compared to the absorbed dose measured by the Fricke solution. Based on MC simulation, the PMMA of the Fricke device increases the D(r0, theta0) by 2.0%. Applying the corresponding correction factor, the D(r0, theta0) value assessed with the Fricke device agrees within 2.0% with the expected value with a total combined uncertainty of 3.43% (k=1). The Fricke device provides a promising method towards calibration of brachytherapy radiation sources in terms of D(r0, theta0) and audit HDR source calibrations.
authors.affiliation: Department of Radiation Oncology, East Carolina University, Greenville, North Carolina 27834, USA. camposc@ecu.edu
authors.forename: C
authors.initials: C
authors.lastname: Austerlitz
authors.forename: H C
authors.initials: HC
authors.lastname: Mota
authors.forename: J
authors.initials: J
authors.lastname: Sempau
authors.forename: S M
authors.initials: SM
authors.lastname: Benhabib
authors.forename: D
authors.initials: D
authors.lastname: Campos
authors.forename: R
authors.initials: R
authors.lastname: Allison
authors.forename: C E
authors.initials: CE
authors.lastname: DeAlmeida
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: C H
authors.initials: CH
authors.lastname: Sibata
mesh_terms: D001918:Brachytherapy / Q000379:methods*; D002138:Calibration; D003198:Computer Simulation; D004867:Equipment Design; D005296:Ferrous Compounds; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D009010:Monte Carlo Method; D018787:Radiation Oncology / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation / Q000379:methods; D012542:Scattering, Radiation; D012996:Solutions; D013053:Spectrophotometry / Q000379:methods; D014867:Water
chemical_list: D005296:Ferrous Compounds; C075364:Fricke solution; D007496:Iridium Radioisotopes; D012996:Solutions; D014867:Water