title: Autologous platelet concentrates for bone graft enhancement in sinus lift procedure.
abstract: BACKGROUND
  Autologous platelet (PLT)-rich plasma has been reported in some studies to promote osteogenesis. The goal of this study was to demonstrate that osteogenesis gained by mixing autologous PLT concentrates (APCs) with a small quantity of autologous bone graft could give a sufficient quality to lead to dental implant placement. The second goal was to compare this osteogenesis with that obtained by a traditional method (iliac bone graft), through clinical, radiologic, and histologic methods.
  
  
  METHODS
  Eighteen patients needing bilateral sinus floor augmentation were enrolled. One sinus was grafted with iliac crest bone alone, and the other sinus with a small quantity of bone and APC. Panoramic view, computed tomography scan, and biopsies were performed 6 months after the initial surgery to compare ossification.
  
  
  RESULTS
  The adjunction of APCs permitted a 60 percent reduction of bone graft required for sinus floor elevation. The bone obtained with APCs had the same histologic and mechanical characteristics as the bone obtained by traditional graft.
  
  
  CONCLUSIONS
  Topical use of APCs might be helpful in bone reconstruction. No clinical, radiologic, or histologic osteogenesis inhibition of high PLT concentration was observed. The resulting osteogenesis was adapted to dental implant placements.
authors.affiliation: Service de Chirurgie Plastique et Maxillo-Faciale, Unité Médicale de Cytologie, and Centre d'Investigation Clinique de Grenoble-INSERM CIC3, CHU A. Michallon, Grenoble Cedex 09, France. GBettega@chu-grenoble.fr
authors.forename: Georges
authors.initials: G
authors.lastname: Bettega
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Brun
authors.forename: Jean
authors.initials: J
authors.lastname: Boutonnat
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Cracowski
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Quesada
authors.forename: Harald
authors.initials: H
authors.lastname: Hegelhofer
authors.forename: Philippe
authors.initials: P
authors.lastname: Drillat
authors.forename: Marie Jeanne
authors.initials: MJ
authors.lastname: Richard
mesh_terms: D000328:Adult; D000540:Alveolar Ridge Augmentation / Q000379:methods; D001792:Blood Platelets / Q000502:physiology; D001804:Blood Transfusion, Autologous; D016025:Bone Transplantation / Q000379:methods*; D003758:Dental Implantation, Endosseous / Q000379:methods; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D017713:Platelet Transfusion / Q000379:methods*; D013515:Surgery, Oral / Q000379:methods*