title: Frequency distribution effects of anchored mother rotors--a computer model study.
abstract: Recent findings indicate that major organized centers (mother rotors) can maintain ventricular fibrillation (VF). In computer models the mother rotors can be induced by local shortening of the action potential duration (APD) in the cardiac tissue. Because of the fact that these rotors tend to drift away towards regions with longer APD, an additional heterogeneity (e.g. bundle) has to be included in the model for stabilizing the activation. Thus, the rotor anchors on this bundle and yields to interesting frequency distribution effects. In the dominant frequency (DF) map of a simplified computer model of the left ventricle it can be observed that the anchoring site of the rotor produces a slightly lower DF than in the surrounding cardiac tissue. That means that due to the load effect of the bundle the frequency is decreased. Furthermore the meandering of the mother rotor around this anchor site is reflected in the spectra of signals taken randomly in the organized region. These effects are both detected with two different independent spectral estimators with different resolutions.
authors.affiliation: Institute of Biomedical Engineering, University for Health Sciences, Medical Informatics and Technology (UMIT), Hall i.T., Austria. claudia.nowak@umit.at
authors.forename: Claudia-Nike
authors.initials: CN
authors.lastname: Nowak
authors.forename: Gerald
authors.initials: G
authors.lastname: Fischer
authors.forename: Leonhard
authors.initials: L
authors.lastname: Wieser
authors.forename: Hans U
authors.initials: HU
authors.lastname: Strohmenger
authors.forename: Bernhard
authors.initials: B
authors.lastname: Tilg
mesh_terms: D000200:Action Potentials; D001683:Biological Clocks; D018780:Body Surface Potential Mapping / Q000379:methods*; D003198:Computer Simulation; D006329:Heart Conduction System / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D014693:Ventricular Fibrillation / Q000503:physiopathology*