title: Comparison of a pulsed dye laser and a combined 585/1,064-nm laser in the treatment of acne vulgaris.
abstract: BACKGROUND
  The effect of combined 585/1,064-nm (sequential dual-wavelength pulsed dye laser (PDL) and neodymium-doped yttrium aluminium garnet) laser therapy for acne vulgaris has not been evaluated.
  
  
  OBJECTIVE
  To compare the efficacy and safety of PDL and of combined 585/1,064-nm laser treatment for mild to moderate facial acne.
  
  
  METHODS
  A 12-week, randomized, prospective, split-face, double-blind study was performed. Sixteen participants with mild to moderate acne were treated with a single pass of a combined 585/1,064-nm laser on half of the face and PDL on the other half during each treatment session. Patients underwent three treatment sessions at 2-week intervals and were followed up at 8 and 12 weeks after treatment commencement.
  
  
  RESULTS
  At the final visit, inflammatory acne lesions were reduced by 86% on the PDL sides and by 89% on the 585/1,064-nm laser sides. Noninflammatory acne lesions showed corresponding reductions of 69% and 64%, respectively. A significant difference between the two treatments was observed for noninflammatory acne lesions at the eighth week. Histopathologic examinations showed that both treatments decreased inflammation and interleukin-8 expression and increased transforming growth factor beta expression.
  
  
  CONCLUSIONS
  PDL and combined 585/1,064 nm laser were safe and effective for the treatment of inflammatory and noninflammatory acne lesions.
authors.affiliation: Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Jung
authors.forename: Yu Sung
authors.initials: YS
authors.lastname: Choi
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Yoon
authors.forename: Seong Uk
authors.initials: SU
authors.lastname: Min
authors.forename: Dae Hun
authors.initials: DH
authors.lastname: Suh
mesh_terms: D000152:Acne Vulgaris / Q000473:pathology / Q000601:surgery*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D054025:Lasers, Dye; D053844:Lasers, Solid-State / Q000627:therapeutic use; D008297:Male; D017060:Patient Satisfaction; D011446:Prospective Studies; D016896:Treatment Outcome