Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones.
This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.
Beer
Philip A
PA
Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Jones
Amy V
AV
Bench
Anthony J
AJ
Goday-Fernandez
Andrea
A
Boyd
Elaine M
EM
Vaghela
Krishna J
KJ
Erber
Wendy N
WN
Odeh
Bassam
B
Wright
Christine
C
McMullin
Mary Frances
MF
Cullis
Jonathan
J
Huntly
Brian J P
BJ
Harrison
Claire N
CN
Cross
Nicholas C P
NC
Green
Anthony R
AR
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002999:Clone Cells / Q000473:pathology; D003582:Cytogenetics; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D049951:X Chromosome Inactivation
D011505:Protein-Tyrosine Kinases