title: Combined EEG/fMRI recording in musicogenic epilepsy.
abstract: Seizures induced by musical stimulation are usually correlated to temporal epilepsy, although the precise localization of their epileptogenic networks are not well characterized. Brain imaging studies show that regional cerebral blood flow (rCBF) recorded during musicogenic seizures is increased in putative epileptogenic foci, as well as in other brain regions not directly related to seizure activity. These studies, however, afford only a virtual temporal relation between ictal discharges and rCBF changes, given that brain images are correlated with off-line EEG recordings. To obviate this problem, the simultaneous multimodal recording of the episode of musicogenic epilepsy is mandatory. The present study describes the EEG-fMRI co-recording of musicogenic elicited seizures in a case of simple partial epilepsy. Our results show that EEG features recorded in epileptogenic areas are largely coupled with rCBF increase. Furthermore, rCBF modifications in other regions suggest that additional aspects of musical processing are also elicited during musicogenic seizures.
authors.affiliation: Dipartimento di Scienze Neurologiche e Cardiovascolari, Università degli Studi di Cagliari, Cagliari, Italy. marrosu@unica.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Marrosu
authors.forename: Luigi
authors.initials: L
authors.lastname: Barberini
authors.forename: Monica
authors.initials: M
authors.lastname: Puligheddu
authors.forename: Marco
authors.initials: M
authors.lastname: Bortolato
authors.forename: Marcello
authors.initials: M
authors.lastname: Mascia
authors.forename: Antonella
authors.initials: A
authors.lastname: Tuveri
authors.forename: Antonella
authors.initials: A
authors.lastname: Muroni
authors.forename: Giorgio
authors.initials: G
authors.lastname: Mallarini
authors.forename: Giuliano
authors.initials: G
authors.lastname: Avanzini
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000098:blood supply* / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D002220:Carbamazepine / Q000627:therapeutic use; D004569:Electroencephalography / Q000379:methods*; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009146:Music; D010100:Oxygen / Q000097:blood
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D010100:Oxygen