title: Dentin enhances the antibacterial effect of mineral trioxide aggregate and bioaggregate.
abstract: The antimicrobial effectiveness of bioaggregate (BA) and mineral trioxide aggregate (MTA) against Enterococcus faecalis was evaluated in vitro. Fresh BA and MTA powders, powder from crushed set materials, and pieces of uncrushed set cements were suspended in autoclaved water at concentrations of 10-100 mg/mL for direct exposure testing. The antimicrobial effect of the cements mixed with equal amounts of human dentin powder was also tested. BA and MTA powder were equally effective in bacterial elimination and caused a significant decrease in bacterial viability within 6 minutes. Powder from crushed set cements was either equally or more effective than fresh powders in killing the bacteria. The addition of equal amounts of dentin powder to the suspension of either BA or MTA powder (both fresh and set) resulted in faster elimination of the bacteria (P < 0.05).
authors.affiliation: Division of Endodontics, Department of Oral Biological & Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Fernanda Geraldes
authors.initials: FG
authors.lastname: Pappen
authors.forename: Markus
authors.initials: M
authors.lastname: Haapasalo
mesh_terms: D017607:Aluminum Compounds / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D017610:Calcium Compounds / Q000494:pharmacology*; D003738:Dental Cements / Q000494:pharmacology; D003804:Dentin / Q000502:physiology*; D004338:Drug Combinations; D013293:Enterococcus faecalis / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D050296:Microbial Viability / Q000187:drug effects; D010087:Oxides / Q000494:pharmacology*; D011208:Powders / Q000494:pharmacology; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates / Q000494:pharmacology*
chemical_list: D017607:Aluminum Compounds; D000891:Anti-Infective Agents, Local; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D010087:Oxides; D011208:Powders; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate