title: Efficient nucleophilic fluoromethylation and subsequent transformation of alkyl and benzyl halides using fluorobis(phenylsulfonyl)methane.
abstract: An efficient methodology for the nucleophilic fluoromethylation of alkyl and benzyl halides using alpha-fluoro-alpha-(phenylsulfonyl)methane (1) as a highly versatile reagent is reported. Using benzyl halides, stereospecific one-pot synthesis of alpha-fluorovinyl compounds such as alpha-fluorostyrylsulfones, alpha-fluorocinnamates, and alpha-fluorochalcones has been achieved. The methodology has been extended toward the synthesis of alpha-substituted fluoroalkane derivatives using selective reductive desulfonylation conditions.
authors.affiliation: Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-1661, USA. gprakash@usc.edu
authors.forename: G K Surya
authors.initials: GK
authors.lastname: Prakash
authors.forename: Sujith
authors.initials: S
authors.lastname: Chacko
authors.forename: Habiba
authors.initials: H
authors.lastname: Vaghoo
authors.forename: Nan
authors.initials: N
authors.lastname: Shao
authors.forename: Laxman
authors.initials: L
authors.lastname: Gurung
authors.forename: Thomas
authors.initials: T
authors.lastname: Mathew
authors.forename: George A
authors.initials: GA
authors.lastname: Olah