[Gender differences in pharmacokinetics of anesthetics].
The gender aspect in pharmacokinetics and pharmacodynamics of anesthetics has attracted little attention. Knowledge of previous work is required to decide if gender-based differences in clinical is justified. Females have 20-30% greater sensitivity to the muscle relaxant effects of vecuronium and rocuronium. When rapid onset of or short duration of action is very important, gender-modified dosing may be considered. Males are more sensitive than females to propofol. It may therefore be necessary to decrease the propofol dose by 30-40% in males compared with females in order to achieve similar recovery times. Females are more sensitive than males to opioid receptor agonists, as shown for morphine as well as for pentazocin. On the other hand, females may experience respiratory depression and other adverse effects more easily if they are given the same doses as males. These examples illustrate that gender should be taken into account as a factor that may be predictive for the dosage of several anesthetic drugs. Moreover, there is an obvious need for more research in this area in order to further optimize drug treatment in anesthesia.
Ueno
Koichi
K
Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8677.
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000493:pharmacokinetics; D000758:Anesthesia; D000777:Anesthetics / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D019388:Cytochrome P-450 CYP1A2 / Q000502:physiology; D051544:Cytochrome P-450 CYP3A / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D012727:Sex Characteristics
D000701:Analgesics, Opioid; D000777:Anesthetics; D003473:Neuromuscular Nondepolarizing Agents; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human