title: Dopamine D1 receptor gene polymorphism is associated with prophylactic lithium response in bipolar disorder.
abstract: BACKGROUND
  Previously, we have found an association between the -48 A/G polymorphism of the dopamine receptor D1 (DRD1) gene and bipolar disorder. The aim of the present study was to investigate a possible association of this polymorphism with the quality of the prophylactic lithium response in bipolar patients.
  
  
  METHODS
  Ninety-two patients (39 male, 53 female), aged 30-77 (mean: 54 years) were studied. They have received lithium for prophylactic purposes for 5-27 years (mean: 15 years). Twenty-four patients were identified as excellent lithium responders (ER), 48 patients as partial responders (PR), and 20 patients were non-responders (NR). They all were genotyped for -48 A/G polymorphism of the DRD1 gene.
  
  
  RESULTS
  The frequency of G/G genotype in ER, PR, and NR patients was 21%, 48%, and 60%, respectively, and the frequency of G allele was 58%, 76%, and 80%, respectively.
  
  
  CONCLUSIONS
  The results obtained suggest that the higher frequency of G allele, and G/G genotype, which has been associated with a predisposition to bipolar illness, is also connected with a poorer prophylactic effect of lithium.
authors.affiliation: Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. rybakows@wlkp.top.pl
authors.forename: J K
authors.initials: JK
authors.lastname: Rybakowski
authors.forename: M
authors.initials: M
authors.lastname: Dmitrzak-Weglarz
authors.forename: A
authors.initials: A
authors.lastname: Suwalska
authors.forename: A
authors.initials: A
authors.lastname: Leszczynska-Rodziewicz
authors.forename: J
authors.initials: J
authors.lastname: Hauser
mesh_terms: D000328:Adult; D000368:Aged; D018692:Antimanic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000235:genetics* / Q000517:prevention & control*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D018021:Lithium Chloride / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic / Q000235:genetics*; D017447:Receptors, Dopamine D1 / Q000235:genetics*
chemical_list: D018692:Antimanic Agents; D017447:Receptors, Dopamine D1; D018021:Lithium Chloride