Memory with emotional content, brain amygdala and Alzheimer's disease.
OBJECTIVE
A highly adaptive aspect of human memory is the enhancement of explicit, consciously accessible memory by emotional stimuli. We studied the performance of Alzheimer's disease (AD) patients and elderly controls using a memory battery with emotional content, and we correlated these results with the amygdala and hippocampus volume.


METHODS
Twenty controls and 20 early AD patients were subjected to the International Affective Picture System (IAPS) and to magnetic resonance imaging-based volumetric measurements of the medial temporal lobe structures.


RESULTS
The results show that excluding control group subjects with 5 or more years of schooling, both groups showed improvement with pleasant or unpleasant figures for the IAPS in an immediate free recall test. Likewise, in a delayed free recall test, both the controls and the AD group showed improvement for pleasant pictures, when education factor was not controlled. The AD group showed improvement in the immediate and delayed free recall test proportional to the medial temporal lobe structures, with no significant clinical correlation between affective valence and amygdala volume.


CONCLUSIONS
AD patients can correctly identify emotions, at least at this early stage, but this does not improve their memory performance.
Schultz
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RR
Behavior Neurology Section, University of Santo Amaro, São Paulo, SP, Brazil. rodrigo@cian.med.br
de Castro
C C
CC
Bertolucci
P H F
PH
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000679:Amygdala / Q000473:pathology* / Q000503:physiopathology; D004522:Educational Status; D004644:Emotions / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D009483:Neuropsychological Tests