title: Ghrelin does not predict adaptive hyperphagia in patients with short bowel syndrome.
abstract: BACKGROUND
  Adaptive hyperphagia is associated with reduced dependence on parenteral nutrition in patients with short bowel syndrome, but mechanisms have not been described. Ghrelin (GHR) has orexigenic effects, whereas peptide YY (PYY) reduces intake. GHR also acts as a hormone to control body fat stores. The authors evaluated whether GHR or PYY was related to caloric intake or absorption in patients with short bowel syndrome and whether GHR was associated with body mass index.
  
  
  METHODS
  Patients were admitted twice for nutrient balance. Height and body weight were obtained using standardized protocols. Energy intake > 40 kcal/kg/day was defined as adaptive hyperphagia. Fasting plasma PYY and GHR were assayed in duplicate with Linco enzyme-linked immunosorbent assay kits.
  
  
  RESULTS
  The median age of the 7 study participants was 62 (range, 45-66) years, time with short bowel syndrome was 6.6 (range, 2-29) years, and body mass index was 21.2 kg/m(2) (range, 19-27.7). Five patients had adaptive hyperphagia. Neither GHR nor PYY was significantly related to energy intake or absorption (GHR: R = 0.22 and R = -0.233, PYY: R = 0.10 and R = -0.13). Body mass index trended toward an inverse association with GHR (GHR: R = -0.540, P = .211).
  
  
  CONCLUSIONS
  The rigorous adaptive hyperphagia seen in these patients with short bowel syndrome was not related to fasting GHR or PYY, suggesting the need to explore other mechanisms.
authors.affiliation: University of Pennsylvania School of Nursing, Philadelphia 19104-6096, USA. compherc@nursing.upenn.edu
authors.forename: Charlene W
authors.initials: CW
authors.lastname: Compher
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Kinosian
authors.forename: David C
authors.initials: DC
authors.lastname: Metz
mesh_terms: D000328:Adult; D000368:Aged; D050218:Body Fat Distribution; D015992:Body Mass Index; D004311:Double-Blind Method; D002149:Energy Intake / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005215:Fasting; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D006963:Hyperphagia / Q000097:blood / Q000209:etiology; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000627:therapeutic use; D010288:Parenteral Nutrition; D019894:Peptide YY / Q000097:blood; D010865:Pilot Projects; D012778:Short Bowel Syndrome / Q000097:blood* / Q000150:complications / Q000503:physiopathology
chemical_list: D054439:Ghrelin; D019894:Peptide YY; D019301:Oleic Acid