title: Glutathione S-transferase P1 gene polymorphism associated with gastric cancer among Caucasians.
abstract: Studies investigating the association between glutathione S-transferase P1 (GSTP1) codon 105 polymorphism and gastric cancer risk report conflicting results. The objective of this study was to quantitatively summarise the evidence for such a relationship. Two investigators independently searched the Medline and Embase databases. This meta-analysis included 10 case-control studies, which included 1161 gastric cancer cases and 2847 controls. The combined results based on all studies showed that there was no significant difference in genotype distribution [AA odds ratio (OR)=1.14, 95% confidence interval (CI)=0.91, 1.44; AG (OR=0.82, 95% CI=0.66, 1.03); GG (OR=1.11, 95% CI=0.55, 2.24)] between gastric cancer and non-cancer patients. When stratifying for race, results were similar except that patients with gastric cancer had a significantly higher frequency of AA (OR=1.53, 95% CI=1.14, 2.06) and lower frequency of AG (OR=0.70, 95% CI=0.55, 0.89) than non-cancer patients among Caucasians. When stratifying by the location and Lauren's classification of gastric cancer, we observed no statistically significant differences in genotype distribution. This meta-analysis suggests that the GSTP1 codon 105 polymorphism may be associated with gastric cancer among Caucasians.
authors.affiliation: Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, 37 Guo Xue Rd., Chengdu 610041, Sichuan Province, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ni
authors.initials: N
authors.lastname: Li
authors.forename: Wen
authors.initials: W
authors.lastname: Zhuang
authors.forename: Yi-Qiong
authors.initials: YQ
authors.lastname: Yin
authors.forename: Guan-Jian
authors.initials: GJ
authors.lastname: Liu
authors.forename: Tai-Xiang
authors.initials: TX
authors.lastname: Wu
authors.forename: Xun
authors.initials: X
authors.lastname: Yao
authors.forename: Liang
authors.initials: L
authors.lastname: Du
authors.forename: Mao-Ling
authors.initials: ML
authors.lastname: Wei
authors.forename: Xiao-Ting
authors.initials: XT
authors.lastname: Wu
mesh_terms: D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D005982:Glutathione Transferase