Sublethal effects of subacute exposure to RDX (1,3,5-trinitro-1,3,5-triazine) in the northern bobwhite (Colinus virginianus).
Northern bobwhite (Colinus virginianus) were orally exposed via gavage to 0, 0.5, 3, 8, 12, or 17 mg/kg of RDX (1,3,5-trinitro-1,3,5-triazine) in corn oil daily for 14 d to evaluate sublethal effects of this explosive in birds. Mortality occurred at a rates of 100, 67, and 25% for the 17, 12, and 8 mg/kg/d dose groups, respectively. Death was preceded by clonic and tonic convulsions and weight loss caused by gastrointestinal effects. Increases in serum globulin and total leukocytes were observed in the two highest-dose groups. Degeneration of testicular and splenic tissue also was observed. The no-observed-adverse-effects and lowest-observed-adverse-effects levels were determined as 3.0 and 8.0 mg/kg/d, respectively.
Quinn
Michael J
MJ
U.S. Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010, USA. michael.james.quinn@us.army.mil
Bazar
Matthew A
MA
McFarland
Craig A
CA
Perkins
Edward J
EJ
Gust
Kurt A
KA
Johnson
Mark S
MS
D000818:Animals; D003088:Colinus; D004305:Dose-Response Relationship, Drug; D053834:Explosive Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D019055:No-Observed-Adverse-Effect Level; D012989:Soil Pollutants / Q000493:pharmacokinetics / Q000633:toxicity*; D014018:Tissue Distribution; D014227:Triazines / Q000493:pharmacokinetics / Q000633:toxicity*; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics / Q000633:toxicity*
D053834:Explosive Agents; D012989:Soil Pollutants; D014227:Triazines; D014874:Water Pollutants, Chemical; C009160:cyclonite