The relationship between leptin level and oxidative status parameters in hemodialysis patients.
Both serum leptin level and oxidative stress are increased in hemodialysis (HD) patients. In the present study, we aimed to investigate whether there is association between oxidative status and leptin level in HD patients. Thirty-five HD patients and 25 healthy controls were enrolled in the present study. Serum leptin level, total peroxide (TP) level, total antioxidant capacity (TAC), and oxidative stress index (OSI) were determined. Serum leptin level, TP level, and OSI were significantly higher in HD patients than controls (all P < 0.001) while TAC was lower (P < 0.001). In HD patients, serum leptin level was significantly correlated with TP level and OSI (r = 0.372, P < 0.001 and r = 0.409, P < 0.001, respectively). The correlation of serum leptin level with TP level and OSI remained statistically significant after adjusting for age, gender, and body-fat percentage (r = 0.446, P < 0.001 and r = 0.463, P < 0.001, respectively). Hyperleptinemia seems to be associated with increased oxidative stress in HD patients, and this association may provide better understanding about the disorders related to either elevated serum leptin levels and/or increased oxidative stress in HD patients.
Horoz
Mehmet
M
Department of Internal Medicine, School of Medicine, Harran University, Sanliurfa, Turkey. mehmethoroz@yahoo.com
Aslan
Mehmet
M
Koylu
Ahmet O
AO
Bolukbas
Cengiz
C
Bolukbas
Filiz F
FF
Selek
Sahbettin
S
Erel
Ozcan
O
D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D010545:Peroxides / Q000097:blood; D006435:Renal Dialysis
D000975:Antioxidants; D020738:Leptin; D010545:Peroxides