title: Effects of grape seed extract and its ethylacetate/ethanol fraction on blood glucose levels in a model of type 2 diabetes.
abstract: The present study observed the effects of grape seed extract (GSE) and its ethylacetate (E) and ethylacetate/ethanol (EE) fractions on blood glucose levels in C57BL/KsJ-lepr(db)/lepr(db) (db/db) mice at 4-12 weeks of age. In the GSE- and EE fraction-treated db/db group, the blood glucose concentration began to be lower than that in the vehicle-treated db/db group at 6 weeks after treatment, while the blood glucose concentration in the E fraction-treated db/db group was similar to that in the vehicle-treated db/db group. The glycosylated hemoglobin (HbA1c) level in the vehicle-treated db/db groups was 9.3%, whereas HbA1c levels in the GSE- and EE fraction-treated db/db group decreased significantly to 5.7% and 6.1%, respectively, at 8 weeks after treatment. However, administration of GSE and its EE fraction did not show any significant effects on body weights and food consumption in db/db mice. These results suggest that GSE and its EE fraction have a potential to decrease the blood glucose and HbA1c level, which is applicable to good healthy foods for reducing blood glucose levels.
authors.affiliation: Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Dae Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Jun Hong
authors.initials: JH
authors.lastname: Park
authors.forename: Soon Sung
authors.initials: SS
authors.lastname: Lim
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kwon
authors.forename: Dong-Woo
authors.initials: DW
authors.lastname: Kim
authors.forename: Won-Kook
authors.initials: WK
authors.lastname: Moon
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004435:Eating / Q000187:drug effects; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry; D027843:Vitis / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D010936:Plant Extracts