title: Animal studies supporting the inhibition of mast cell activation by Eriobotrya japonica seed extract.
abstract: OBJECTIVE
  The potent antioxidant activity of Eriobotrya japonica seed extract (ESE) and its usefulness in the prevention and treatment of various disorders has been reported previously. Its antioxidant activity associated with beta-sitosterol and polyphenols contained in the extract was also validated. In this study, anti-allergic activity of Eriobotrya japonica seed extract was investigated.
  
  
  METHODS
  The inhibition of histamine release-mediated type 1 allergy by Eriobotrya japonica seed extract was used as an index.
  
  
  RESULTS
  The administration of this extract inhibited histamine release from rat mast cells, suggesting its usefulness in allergic disease treatment. In an experiment using a guinea-pig allergic rhinitis model, this extract reduced the frequency of sneezing and nose-scratching.
  
  
  CONCLUSIONS
  These results suggest that Eriobotrya japonica seed extract may contribute to the relief of allergic disease-related symptoms.
authors.affiliation: Department of Biomedical Science, Kochi Medical Graduate School, Kochi, Japan. jm-ma_ono@kochi-u.ac.jp
authors.forename: Masahide
authors.initials: M
authors.lastname: Onogawa
authors.forename: Guangchen
authors.initials: G
authors.lastname: Sun
authors.forename: Daisuke
authors.initials: D
authors.lastname: Takuma
authors.forename: Atsuhide
authors.initials: A
authors.lastname: Hamada
authors.forename: Junko
authors.initials: J
authors.lastname: Yokota
authors.forename: Saburo
authors.initials: S
authors.lastname: Yoshioka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kusunose
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Miyamura
authors.forename: Shojiro
authors.initials: S
authors.lastname: Kyotani
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishioka
mesh_terms: D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D031983:Eriobotrya / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D010529:Peritoneal Cavity / Q000166:cytology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012221:Rhinitis, Allergic, Perennial / Q000517:prevention & control; D006255:Rhinitis, Allergic, Seasonal / Q000517:prevention & control; D012639:Seeds / Q000737:chemistry; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D012912:Sneezing / Q000187:drug effects
chemical_list: D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase