title: Does Helicobacter pylori-induced inflammation of gastric mucosa determine the severity of symptoms in functional dyspepsia?
abstract: BACKGROUND
  Inflammation induces some structural and biochemical alterations and oxidative damage in gastric tissue. In this study, we aimed to investigate the relationship among the severity of symptoms, oxidative stress, and grading scales of Helicobacter pylori-induced gastric inflammation in functional dyspepsia.
  
  
  METHODS
  Thirty-five patients with functional dyspepsia were enrolled in the study. The severity of dyspepsia within the last 6 months was evaluated by Glasgow Dyspepsia Severity Score. In biopsy specimens of gastric mucosa, severity of gastritis was estimated by the revised Sydney Classification System, and oxidative stress parameters were studied.
  
  
  RESULTS
  Although there was no statistically significant relationship between symptom scores and degree of chronic inflammation, a tendency for symptoms to be more severe has been observed in low levels of gastritis. Levels of sulfhydryl groups were lower in subjects with high levels of chronic inflammation, and Helicobacter pylori intensity (P < 0.001 and P = 0.02, respectively). Levels of malondialdehyde were higher in subjects with high levels of chronic inflammation (P = 0.04). There was a statistically significant but a weak positive correlation between symptom scores and sulfhydryl levels (P < 0.001, r = 0.323).
  
  
  CONCLUSIONS
  In conclusion, there may be an inverse relation between severity of symptoms and level of Helicobacter pylori induced gastric inflammation or oxidative stress in patients with functional dyspepsia.
authors.affiliation: Department of Internal Medicine, School of Medicine, Afyon Kocatepe University, Afyonkarahisar, Turkey.
authors.forename: Ebru
authors.initials: E
authors.lastname: Turkkan
authors.forename: Ihsan
authors.initials: I
authors.lastname: Uslan
authors.forename: Gursel
authors.initials: G
authors.lastname: Acarturk
authors.forename: Nevin
authors.initials: N
authors.lastname: Topak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kahraman
authors.forename: Fatma Husniye
authors.initials: FH
authors.lastname: Dilek
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Akcan
authors.forename: Ozcan
authors.initials: O
authors.lastname: Karaman
authors.forename: Mehmet
authors.initials: M
authors.lastname: Colbay
authors.forename: Seref
authors.initials: S
authors.lastname: Yuksel
mesh_terms: D000328:Adult; D000368:Aged; D004415:Dyspepsia / Q000145:classification / Q000382:microbiology / Q000503:physiopathology*; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000382:microbiology / Q000503:physiopathology*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007249:Inflammation / Q000382:microbiology / Q000503:physiopathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress; D012720:Severity of Illness Index; D013438:Sulfhydryl Compounds / Q000378:metabolism; D055815:Young Adult
chemical_list: D013438:Sulfhydryl Compounds; D008315:Malondialdehyde