Novel norhumulene and xeniaphyllane-derived terpenoids from a formosan soft coral Sinularia gibberosa.
A novel skeletal norhumulene (1) and six xeniaphyllane-derived compounds, including norditerpenoids (2, 3) and diterpenoids (4-7), were isolated from the EtOAc extract of the Formosan soft coral Sinularia gibberosa. Their structures were elucidated by spectroscopic analysis. In vitro cytotoxic evaluation of the above metabolites revealed that 2 and 4 showed weak cytotoxicity toward a few cancer cell lines.
Chen
Shin-Pin
SP
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Su
Jui-Hsin
JH
Yeh
Hsiao-Chien
HC
Ahmed
Atallah Fouad
AF
Dai
Chang-Feng
CF
Wu
Yang-Chang
YC
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000032:analysis; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry*; D013778:Tetrazolium Salts; D013844:Thiazoles
D000970:Antineoplastic Agents; D004224:Diterpenes; D000081222:Monocyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C042686:humulene; C022616:thiazolyl blue