title: Tau aggregation in Alzheimer's disease: what role for phosphorylation?
abstract: The crucial role of the neuronal Tau protein in microtubule stabilization and axonal transport suggests that too little or too much Tau might lead to neuronal dysfunction. The presence of a hyper phosphorylated but non aggregated molecule as a toxic species that might sequester normal Tau is discussed. We present recent in vitro results that might allow us to dissect the role of individual phosphorylation sites on its structure and function. We also discuss in this review the role of phosphorylation for the aggregation of the neuronal Tau protein, and compare it to the aggregation induced by external poly anions.
authors.affiliation: CNRS UMR 8576, Unité de Glycobiologie Structurale et Fonctionnelle, Université des Sciences et Technologies de Lille 1, Villeneuve d'Ascq, France. Guy.Lippens@univ-lille1.fr
authors.forename: Guy
authors.initials: G
authors.lastname: Lippens
authors.forename: Alain
authors.initials: A
authors.lastname: Sillen
authors.forename: Isabelle
authors.initials: I
authors.lastname: Landrieu
authors.forename: Laziza
authors.initials: L
authors.lastname: Amniai
authors.forename: Nathalie
authors.initials: N
authors.lastname: Sibille
authors.forename: Pascale
authors.initials: P
authors.lastname: Barbier
authors.forename: Arnaud
authors.initials: A
authors.lastname: Leroy
authors.forename: Xavier
authors.initials: X
authors.lastname: Hanoulle
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Wieruszeski
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D020836:Protein Structure, Quaternary; D021381:Protein Transport; D013329:Structure-Activity Relationship; D016875:tau Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins