Restored cardiac conditions and left ventricular function after parathyroidectomy in a hemodialysis patient. Parathyroidectomy improves cardiac fatty acid metabolism assessed by 123I-BMIPP.
A 62 year-old female hemodialysis patient underwent parathyroidectomy to treat secondary hyperparathyroidism. On the preoperative assessment, the plasma levels of parathyroid hormone (PTH) and B-type natriuretic peptide (BNP) were elevated. Echocardiography showed reduced left ventricular (LV) contraction. Myocardial iodine-123-15-(p-iodophenyl)-3-(R,S) methylpentadecanoic acid ((123)I-BMIPP) scintigraphy showed moderately reduced tracer uptake in the postero-inferior area on single-photon emission computed tomography and decreased washout on the planar images. After parathyroidectomy, the plasma levels of PTH and BNP decreased, followed by improvement in LV contraction. Myocardial (123)I-BMIPP scintigraphy revealed that the washout on planar images had increased, which suggests that myocardial (123)I-BMIPP scintigraphy is useful for estimating the effect of parathyroidectomy on cardiac function.
Nanasato
Mamoru
M
Cardiovascular Center, Nagoya Daini Red Cross Hospital, Japan. nana@nagoya2.jrc.or.jp
Goto
Norihiko
N
Isobe
Satoshi
S
Unno
Kazumasa
K
Hirayama
Haruo
H
Sato
Tetsuhiko
T
Matsuoka
Susumu
S
Nagasaka
Takaharu
T
Tominaga
Yoshihiro
Y
Uchida
Kazuharu
K
Murohara
Toyoaki
T
D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology / Q000378:metabolism / Q000601:surgery*; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism / Q000628:therapy; D008875:Middle Aged; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D019275:Radiopharmaceuticals; D020127:Recovery of Function; D006435:Renal Dialysis; D013318:Stroke Volume; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D016277:Ventricular Function, Left
D015415:Biomarkers; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D010281:Parathyroid Hormone; D019275:Radiopharmaceuticals; C049338:iodofiltic acid; D020097:Natriuretic Peptide, Brain