title: Clonal diversity in the myeloproliferative neoplasms: independent origins of genetically distinct clones.
abstract: This study looked for clonal diversity in patients with a myeloproliferative neoplasm associated with more than one acquired genetic lesion. A tyrosine kinase mutation and a cytogenetic lesion were present in the same clone in six of seven patients. By contrast, the genetic lesions were present in separate clones in all six patients with two tyrosine kinase pathway mutations. Moreover, in two patients the clones were genetically unrelated by X-chromosome inactivation studies. These data demonstrated clonal diversity in a subset of patients with early stage haematopoietic malignancy and showed, for the first time, that such clones may arise independently.
authors.affiliation: Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
authors.forename: Philip A
authors.initials: PA
authors.lastname: Beer
authors.forename: Amy V
authors.initials: AV
authors.lastname: Jones
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Bench
authors.forename: Andrea
authors.initials: A
authors.lastname: Goday-Fernandez
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Boyd
authors.forename: Krishna J
authors.initials: KJ
authors.lastname: Vaghela
authors.forename: Wendy N
authors.initials: WN
authors.lastname: Erber
authors.forename: Bassam
authors.initials: B
authors.lastname: Odeh
authors.forename: Christine
authors.initials: C
authors.lastname: Wright
authors.forename: Mary Frances
authors.initials: MF
authors.lastname: McMullin
authors.forename: Jonathan
authors.initials: J
authors.lastname: Cullis
authors.forename: Brian J P
authors.initials: BJ
authors.lastname: Huntly
authors.forename: Claire N
authors.initials: CN
authors.lastname: Harrison
authors.forename: Nicholas C P
authors.initials: NC
authors.lastname: Cross
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Green
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002999:Clone Cells / Q000473:pathology; D003582:Cytogenetics; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000473:pathology; D006412:Hematopoietic Stem Cells / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D049951:X Chromosome Inactivation
chemical_list: D011505:Protein-Tyrosine Kinases