The effect of transarterial prostate embolization in hormone-induced benign prostatic hyperplasia in dogs: a pilot study.
OBJECTIVE
To evaluate the feasibility of transarterial prostate embolization for reducing the volume in hormone-induced canine prostate hyperplasia.


METHODS
Nine beagle dogs were included in this study. Prostate hyperplasia was induced by administering dihydrotestosterone and beta-estradiol. The hormones were given for 12 weeks in group A (n = 4) and 24 weeks in group B (n = 5). Twelve weeks after initiating the hormone treatment, two animals in group A and three in group B underwent prostate embolization with polyvinyl alcohol (PVA) particles. The volume of each prostate was measured three times with magnetic resonance (MR) imaging: once before hormone treatment and at 12 and 24 weeks after initiation of hormone administration. The prostates and bladders were harvested after the third MR study and were grossly and microscopically evaluated.


RESULTS
The mean volume of the prostate increased by 156.13% +/- 110.01% in the nine dogs after 12 weeks of hormone administration. In group A (n = 4), the third MR study showed a 67.74% mean decrease in prostate volume in nonembolized dogs and an 81.04% mean decrease in embolized dogs compared with the second MR study. In group B (n = 5), the mean increases in prostate volume between the second and third MR studies were 40.79% in embolized dogs (n = 3) and 75.15% in nonembolized dogs. There was no gross or microscopic change in the bladders except for a focal hemorrhage in one specimen.


CONCLUSIONS
Transcatheter arterial embolization is feasible for reducing prostate volume without serious complications in hormone-induced canine prostate hyperplasia.
Jeon
Gyeong Sik
GS
Department of Radiology, Ajou University Hospital, School of Medicine, Suwon, Republic of Korea.
Won
Je Hwan
JH
Lee
Byung Mo
BM
Kim
Jang Hee
JH
Ahn
Hyun Soo
HS
Lee
Eun Ju
EJ
Park
Sung Il
SI
Park
Sang Woo
SW
D000818:Animals; D013196:Dihydrotestosterone; D004195:Disease Models, Animal; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D004958:Estradiol; D005240:Feasibility Studies; D006728:Hormones; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced / Q000628:therapy; D008297:Male; D010865:Pilot Projects; D011142:Polyvinyl Alcohol / Q000008:administration & dosage*; D011467:Prostate / Q000187:drug effects* / Q000473:pathology*; D016896:Treatment Outcome
D006728:Hormones; D013196:Dihydrotestosterone; D004958:Estradiol; D011142:Polyvinyl Alcohol