Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits.
In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits.
Ahn
Chan Mug
CM
Department of Basic Sciences and Institute of Basic Medical Science, Wonju College of Medicine, Yonsei University, Wonju 220-701, Republic of Korea.
Park
Byong-Gon
BG
Woo
Ho Bum
HB
Ham
Jungyeob
J
Shin
Woon-Seob
WS
Lee
Seokjoon
S
D000818:Animals; D001488:Basilar Artery / Q000187:drug effects / Q000502:physiology*; D003474:Curcumin / Q000138:chemical synthesis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008297:Male; D018716:Molecular Mimicry / Q000502:physiology; D011817:Rabbits; D013441:Sulfinic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000494:pharmacology
D013441:Sulfinic Acids; D014665:Vasodilator Agents; D003474:Curcumin