title: Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens.
abstract: Perilla frutescens is a food plant widely used in Asian cuisine. This plant was investigated for its interesting taste and somatosensory properties. Perillaldehyde and perillaketone are among the components of the aromatic extracts from P. Frutescens. These compounds were shown here to activate the cloned TRPA1 channel when expressed in an heterologous cell system and are therefore suggested to be responsible for the chemesthetic properties of this plant.
authors.affiliation: DISMA, Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Milano, Italy. angela.bassoli@unimi.it
authors.forename: Angela
authors.initials: A
authors.lastname: Bassoli
authors.forename: Gigliola
authors.initials: G
authors.lastname: Borgonovo
authors.forename: Sara
authors.initials: S
authors.lastname: Caimi
authors.forename: Leonardo
authors.initials: L
authors.lastname: Scaglioni
authors.forename: Gabriella
authors.initials: G
authors.lastname: Morini
authors.forename: Aniello Schiano
authors.initials: AS
authors.lastname: Moriello
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Di Marzo
authors.forename: Luciano
authors.initials: L
authors.lastname: De Petrocellis
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D039821:Monoterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D031344:Perilla frutescens / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013649:Taste; D014162:Transfection; D050051:Transient Receptor Potential Channels / Q000819:agonists*
chemical_list: D000975:Antioxidants; D039821:Monoterpenes; D010936:Plant Extracts; D050051:Transient Receptor Potential Channels; C033342:perillaldehyde; C015426:perilla ketone