Developmental brain protein level changes in the C57BL/6J mouse.
As work on systematic searches for developmentally-regulated proteins is limited, whole brains of CL57B/6J mice were taken from day 16 of gestation, at postnatal days 7 and 54-58. Proteins were extracted, and analyzed by a gel-based proteomic method (ion trap HCT). Antioxidant, cytoskeleton, chaperone, several metabolic proteins from different pathways, proteins from the protein synthetic and degradation machinery, sirtuin and a mitochondrial inner membrane protein were developmentally regulated.
Myung
Jae-Kyung
JK
Department of Pediatrics, Medical University of Vienna, Vienna, Austria.
Shim
Ki Shuk
KS
Li
Lin
L
Höger
Harald
H
Lubec
Gert
G
D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D002853:Chromatography, Liquid; D015180:Electrophoresis, Gel, Two-Dimensional; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D055495:Neurogenesis / Q000502:physiology*; D020543:Proteome / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization
D020543:Proteome