title: Effect of a single bout of moderate exercise on glucose uptake in type 2 diabetes mellitus.
abstract: OBJECTIVE
  Hypoglycemia during exercise is a serious problem in diabetic patients during cardiac rehabilitation, whereas normal subjects rarely experience hypoglycemia. Inappropriate glucose uptake by working muscles may be responsible. However, the precise characteristics of glucose uptake during exercise have not been fully studied. We have investigated the effect of acute exercise on glucose uptake in diabetic patients.
  
  
  METHODS
  Nine type 2 diabetic patients (age, 57 ± 6 years; HbA1c, 7.7 ± 1.3%) performed exercise at an intensity of anaerobic threshold for 15 min. Glucose utility was determined using euglycemic hyperinsulinemic clamp technique. Glucose infusion rate (GIR) was calculated throughout the exercise and recovery session.
  
  
  RESULTS
  Average GIR at rest was 3.4 ± 1.6 mg/(kg(BW)min). Fifteen minutes after starting exercise, it increased significantly (6.6 ± 2.4, p < 0.001). Thirty minutes after cessation of exercise, GIR decreased significantly (4.8 ± 1.9, p < 0.05) compared with peak value. Increase in GIR was greater as BMI or body fat ratio became greater (r=0.608 and 0.475). There was a weak correlation (r=0.344) between HbA1c and GIR improving ratio (GIR during exercise x 100/GIR at rest).
  
  
  CONCLUSIONS
  Glucose uptake was revealed to augment significantly within 15 min after the commencement of exercise. This improvement was more obvious in patients with greater body weight, fat accumulation, and poorer diabetic control.
authors.affiliation: Department of Medicine and Biological Science, Graduate School of Medicine, Gunma University, Gunma, Japan.
authors.forename: Masato
authors.initials: M
authors.lastname: Oguri
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Adachi
authors.forename: Tomio
authors.initials: T
authors.lastname: Ohno
authors.forename: Shigeru
authors.initials: S
authors.lastname: Oshima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
mesh_terms: D000693:Anaerobiosis; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged
chemical_list: D005947:Glucose