Accelerated antioxidant bioavailability of OPC-3 bioflavonoids administered as isotonic solution.
The degree of absorption of bioflavonoids, a diverse and complex group of plant derived phytonutrients, has been a frequent debate among scientists. Monomeric flavonoid species are known to be absorbed within 2 h. The kinetics of plasma reactive oxygen species, a reflection of bioactivity, of a commercial blend of flavonoids, OPC-3 was investigated. OPC-3 was selected to compare absorption of an isotonic flavonoid solution vs tablet form with the equivalent amount of fluid. In the case of isotonic OPC-3 the reactive oxygen species of the subject's plasma decreased significantly (p < 0.05), six times greater than OPC-3 tablets by 10 min post-consumption. After 20 min the isotonic formulation was approximately four times more bioavailable and after 40 min twice as bioavailable as the tablet, respectively. At time points 1 h and later, both isotonic and tablet formulations lowered oxidative stress, although the isotonic formulation values remained significantly better throughout the investigation period of 4 h. These findings point to a dramatically accelerated bioavailability of flavonoids delivered in an isotonic formulation.
Cesarone
Maria R
MR
Department of Biomedical Science, G D'Annunzio University Chieti, Pescara, Italy.
Grossi
Maria Giovanni
MG
Di Renzo
Andrea
A
Errichi
Silvia
S
Schönlau
Frank
F
Wilmer
James L
JL
Lange
Mark
M
Blumenfeld
Julian
J
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001682:Biological Availability; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D007552:Isotonic Solutions; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000097:blood; D013607:Tablets
D000975:Antioxidants; D005419:Flavonoids; D007552:Isotonic Solutions; D017382:Reactive Oxygen Species; D013607:Tablets