Isolation and structure of hematoside-type ganglioside from the starfish Linckia laevigata.
A hematoside-type ganglioside, LLG-1 (1), has been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Linckia laevigata. The structure of the ganglioside has been determined on the basis of chemical and spectroscopic evidence as 1-O-[N-glycolyl-alpha-D-neuraminosyl-(2-->3)-beta-D-galactopyranosyl-(1-->4)-beta-D-glucopyranosyl]-ceramide. The ceramide moiety was composed of heterogeneous 2-hydroxy fatty acid and phytosphingosine units. This is the first report on the isolation and structure elucidation of naked hematoside-type ganglioside from echinoderms.
Inagaki
Masanori
M
Faculty of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
Saito
Takeshi
T
Miyamoto
Tomofumi
T
Higuchi
Ryuichi
R
D000818:Animals; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification; D002855:Chromatography, Thin Layer; D005679:G(M3) Ganglioside / Q000737:chemistry* / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D008745:Methylation; D020383:Neutral Glycosphingolipids / Q000737:chemistry* / Q000302:isolation & purification; D013215:Starfish / Q000737:chemistry*; D014020:Tissue Extracts / Q000737:chemistry
D002518:Ceramides; D005679:G(M3) Ganglioside; D020383:Neutral Glycosphingolipids; D014020:Tissue Extracts; C539048:ganglioside LLG-1; D000432:Methanol