A fluorous-tagged "safety catch" linker for preparing heterocycles by ring-closing metathesis.
A fluorous-tagged "safety catch" linker is described for the synthesis of heterocycles with use of ring-closing metathesis. The linker facilitates the purification of metathesis substrates, the removal of the catalyst, the functionalization of the products, and the release of only metathesis products. The synthesis of a range of heterocycles is described.
O'Leary-Steele
Catherine
C
School of Chemistry and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds, LS2 9JT, United Kingdom.
Cordier
Christopher
C
Hayes
Jerome
J
Warriner
Stuart
S
Nelson
Adam
A
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003432:Cross-Linking Reagents / Q000737:chemistry; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D015394:Molecular Structure
D003432:Cross-Linking Reagents; D006571:Heterocyclic Compounds; D006845:Hydrocarbons, Fluorinated