title: Human respiratory syncytial virus infects and induces activation markers in mouse B lymphocytes.
abstract: Human respiratory syncytial virus (HRSV) is the most common cause of severe respiratory infections in infants and young children, often leading to hospitalization. Although human airway epithelial cells are the main target of HRSV, it has been reported that this virus can also infect professional antigen-presenting cells such as macrophages and dendritic cells, promoting upregulation of maturation markers. Here, we report that mouse spleen B220(+) B lymphocytes were susceptible to HRSV infection in vitro, probably involving a glycosaminoglycan-dependent mechanism. In contrast, neither CD4(+) nor CD8(+) T lymphocytes were infected. In B lymphocytes, HRSV infection upregulated major histocompatibility complex (MHC) class II but not MHC class I molecules and induced the expression of the activation marker CD86.
authors.affiliation: Unidad de Proteómica, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Angel Rico
authors.forename: Alfonsina
authors.initials: A
authors.lastname: Trento
authors.forename: Manuel
authors.initials: M
authors.lastname: Ramos
authors.forename: Carolina
authors.initials: C
authors.lastname: Johnstone
authors.forename: Margarita
authors.initials: M
authors.lastname: Del Val
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Melero
authors.forename: Daniel
authors.initials: D
authors.lastname: López
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000821:virology; D015415:Biomarkers / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D006025:Glycosaminoglycans / Q000276:immunology / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D000949:Histocompatibility Antigens Class II / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000821:virology; D018113:Respiratory Syncytial Virus, Human / Q000502:physiology*
chemical_list: D015415:Biomarkers; D006025:Glycosaminoglycans; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II