Comparative effects of different cosurfactants on sterile prednisolone acetate ocular submicron emulsions stability and release.
Pluronic F68 is a nonionic, thermogelling block copolymer showing a high dehydration resistance during autoclaving due to its high cloud point (>100 degrees C). Tween 80 (with cloud point of 72.5 degrees C), is a polyoxyethylene-based cosurfactant, susceptible to temperature because of a decrease in its solubility by temperature increase. This study was done to explore whether or not, when compared with Tween 80, Pluronic F68 could be used blindly as a suitable cosurfactant for the preparation of terminally sterilized ocular submicron emulsions containing a lipid soluble drug, prednisolone acetate (PA). Various oils of variable viscosities were also tried. The results proved that no prediction can be made based on previously known physico-chemical properties alone and that emulsion stability depends on the contribution of the various emulsion components including: oil, surfactant and cosurfactant, in addition to the drug properties.
Ibrahim
Shaimaa S
SS
Ain Shams University, Department of Pharmaceutics, Cairo, Egypt. sheema_sayed@yahoo.com
Awad
Gehanne A S
GA
Geneidi
Ahmed
A
Mortada
Nahed D
ND
D000818:Animals; D002368:Castor Oil / Q000737:chemistry; D055598:Chemical Phenomena; D004355:Drug Stability; D004655:Emulsions; D005123:Eye; D005260:Female; D008070:Lipopolysaccharides; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013024:Soybean Oil / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D014605:Uveitis / Q000139:chemically induced / Q000188:drug therapy; D014783:Viscosity
D004655:Emulsions; D008070:Lipopolysaccharides; D011136:Polysorbates; D013501:Surface-Active Agents; D020442:Poloxamer; D013024:Soybean Oil; D002368:Castor Oil; C009935:prednisolone acetate; D011239:Prednisolone