Circadian clocks can take a few transcriptional knocks.
A thought-provoking study in this issue of The EMBO Journal shows that the circadian clock in mouse fibroblasts is surprisingly insensitive to the inhibition of total cellular mRNA production. The authors go on to show intriguing parallels between compensation of period to changes in temperature and global transcription rate.
O'Neill
John S
JS
Centre for Systems Biology at Edinburgh, The University of Edinburgh, Biological Sciences, Edinburgh, UK. john.oneill@ed.ac.uk
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D002940:Circadian Rhythm / Q000502:physiology*; D056931:Cryptochromes; D025461:Feedback, Physiological / Q000502:physiology; D005420:Flavoproteins / Q000378:metabolism*; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D056950:Period Circadian Proteins; D012319:RNA Polymerase II / Q000378:metabolism; D013696:Temperature; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D018797:Cell Cycle Proteins; D056931:Cryptochromes; D005420:Flavoproteins; D009687:Nuclear Proteins; C539023:Per1 protein, mouse; C513312:Per2 protein, mouse; D056950:Period Circadian Proteins; D014157:Transcription Factors; D012319:RNA Polymerase II