Bilateral vocal cord paralysis following treatment with vincristine.
The neurotoxicity of the vincristine is well known, however, cranial neuropathy is not widely recognized. We describe a child with acute lymphoblastic leukemia who developed vincristine-induced bilateral vocal cord paralysis. Vocal cord paralysis resolved spontaneously upon withdrawal of the vincristine. Vinca-alkaloid-induced vocal cord paralysis is a potentially dangerous but reversible condition.
Naithani
Rahul
R
Department of Hematology, All India Institute of Medical Sciences, New Delhi 110 029, India. dr_rahul6@hotmail.com
Dolai
Tuphan Kanti
TK
Kumar
Rajat
R
D000293:Adolescent; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D014750:Vincristine / Q000009:adverse effects* / Q000627:therapeutic use; D014826:Vocal Cord Paralysis / Q000139:chemically induced*
D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine