title: [Depression and response: impact of personality and cognition].
abstract: OBJECTIVE
  Despite effective pharmacologic and therapeutic strategies some patients do not sufficiently benefit from antidepressive treatment. The influence of personality and cognition onto response in depressive inpatients shall be explored.
  
  
  METHODS
  Depressive inpatients were rated concerning depressive pathology immediately after admission as well as at discharge. In addition, prior to discharge, cognitive performance and personality traits were measured. The sample was divided into responders and nonresponders by the reduction of depressive symptoms from admission to discharge. For the assumption of response, a reduction of minimum 50 % was defined.
  
  
  RESULTS
  Preliminary results suggest an impact of personality traits onto response in depressive patients, particularly extraversion seems to have a salutary effect. Furthermore, significant differences between responders and nonresponders were shown concerning alertness.
  
  
  CONCLUSIONS
  In the treatment of non-response depression, cognitive and personality traits should be taken in account by using multimodal strategies.
authors.affiliation: Abteilung Neuropsychologie, Inn-Salzach-Klinikum, Fachkrankenhaus für Psychiatrie, Psychotherapie, Psychosomatische Medizin und Neurologie, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität München. irmgard-david@freenet.de
authors.forename: Irmgard
authors.initials: I
authors.lastname: David
authors.forename: Alexander
authors.initials: A
authors.lastname: Brunnauer
authors.forename: Gerd
authors.initials: G
authors.lastname: Laux
authors.forename: Sarah
authors.initials: S
authors.lastname: Zwick
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D001288:Attention; D002605:Character; D003071:Cognition; D003131:Combined Modality Therapy; D003866:Depressive Disorder / Q000628:therapy*; D005120:Extraversion, Psychological; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D011939:Mental Recall; D008875:Middle Aged; D009042:Motivation; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D010555:Personality Inventory / Q000706:statistics & numerical data; D011340:Problem Solving; D011594:Psychometrics; D011613:Psychotherapy; D012153:Retention, Psychology; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents