title: [Contraception in women with special problems].
abstract: Thromboembolic, cardiovascular and cerebrovascular events are age-dependent. They are extremely rare in young women. In contrast to the progestogen-only pills, oral contraceptives (OC) increase the risk of venous thrombosis. However, decisive ist the genetic predisposition. In healthy non-smokers of less than 35 years of age, the risk to suffer from a myocardial infarction or a cerebrovascular accident is not increased by OC. Risk factors play a major role in the etiology of cardiovascular diseases. A detailed personal and family history is therefore mandatory before OC are prescribed. Very rarely, blood pressure is increased by OC. Although the incidence of such an increase is very low, blood pressure has to be measured regularly in pill users. Inspite of a current opinion, weight increase is rare in OC users. It depends mainly on the individual predisposition. An increased water retention can be reduced by a combined OC containing a progestagen with an antimineralocorticoid activity. Changes in insulin and blood sugar induced by low-dose OC are minimal so that they have no clinical relevance. OC do not increase the incidence of diabetes. Adrenal and thyroid function are not influenced by OC, there is no increased incidence of prolactinomas. Asthma is no contraindication against OC. If there is a cycle-dependent aggravation of the disease, OC might be beneficial. OC have no side-effects on the eye or the ear. In women suffering from lupus erythematodes having no renal participation, no increased antiphospholipid-antibodies and showing a stable or inactive disease, low-dose OC might be used.
authors.affiliation: Landesinstitut für Frauengesundheit Baden-Württemberg, Universitätsfrauenklinik Tübingen. endo.meno@med.uni-tuebingen.de
authors.forename: Alfred
authors.initials: A
authors.lastname: Mueck
authors.forename: Joseph
authors.initials: J
authors.lastname: Neulen
authors.forename: Christian
authors.initials: C
authors.lastname: Thaler
authors.forename: Martin
authors.initials: M
authors.lastname: Birkhäuser
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Braendle
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kiesel
authors.forename: Herbert
authors.initials: H
authors.lastname: Kuhl
mesh_terms: D000328:Adult; D001066:Appetite / Q000187:drug effects; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000235:genetics; D003276:Contraceptives, Oral / Q000008:administration & dosage / Q000009:adverse effects*; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D011372:Progestins / Q000008:administration & dosage / Q000009:adverse effects; D013923:Thromboembolism / Q000139:chemically induced* / Q000235:genetics; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D004967:Estrogens; D011372:Progestins