[Studies on cyclodextrin inclusion complexes of Dragon's blood and its tablets preparation].
OBJECTIVE
To study the cyclodextrin inclusion complexes of Dragon's blood for improving the drug solubility and the preparation.


METHODS
The inclusion complexes were prepared with beta-cyclodextrin, HP-beta-cyclodextrin, SBE-beta-cyclodextrin and confirmed by DTA. The activity of the inclusion complex was tested by animal experiments. Inclusion complexes tablets were prepared and the dissolution test was performed.


RESULTS
The solubility of inclusion complexes was increased to 13. 75-168. 39 times. The activity of the inclusion complex was markedly improved, and dissolution rate was 78.69%.


CONCLUSIONS
The cyclodextrin inclusion complexes of Dragon's blood have a good solubility, dissolution rate and pharmacological activity.
Han
Bin-Bin
BB
Jiangsu Key Laboratory for Supramolecular Medicinal Materials and Applications, Nanjing 210046, China.
Pei
Hui-Na
HN
Sun
Hai-Song
HS
Ning
Quan-Kui
QK
Ren
Yong
Y
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D003505:Cyclodextrins / Q000737:chemistry*; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D012995:Solubility; D013607:Tablets / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry
D003505:Cyclodextrins; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D013607:Tablets; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; C093196:SBE4-beta-cyclodextrin; C031215:betadex; C525191:dragon's blood