title: On the synthesis of multiple frequency tone burst stimuli for efficient high frequency auditory brainstem response.
abstract: The development and digital waveform synthesis of a multiple-frequency tone-burst (MFTB) stimulus is presented. The stimulus is designed to improve the efficiency of monitoring high-frequency auditory-brainstem-response (ABR) hearing thresholds. The pure-tone-based, fractional-octave-bandwidth MFTB supports frequency selective ABR audiometry with a bandwidth that falls between the conventional click and single-frequency tone-burst stimuli. The MFTB is being used to identify high frequency hearing threshold change due to ototoxic medication which most generally starts at the ultra-highest hearing frequencies and progresses downwards but could be useful in general limited-bandwidth testing applications. Included is a Mathcad implementation and analysis of our MFTB synthesis technique and sample performance measurements of the MFTB stimulus configuration used in a clinical research ABR system.
authors.affiliation: National Center for Rehabilitative Auditory Research (NCRAR), VA Medical Center, 3710 SW US Veterans Hospital Road, Portland, OR 97207, USA. Roger.Ellingson@med.va.gov
authors.forename: Roger M
authors.initials: RM
authors.lastname: Ellingson
authors.forename: Marilyn L
authors.initials: ML
authors.lastname: Dille
authors.forename: Marjorie R
authors.initials: MR
authors.lastname: Leek
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Fausti
mesh_terms: D000465:Algorithms; D001300:Audiometry, Evoked Response / Q000379:methods*; D001301:Audiometry, Pure-Tone / Q000379:methods*; D001309:Auditory Threshold / Q000502:physiology*; D002138:Calibration; D003201:Computers; D001330:Electronic Data Processing; D004867:Equipment Design; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D006801:Humans; D015233:Models, Statistical; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D012984:Software; D013997:Time Factors