Analysis of postprandial lipemia as a Cardiovascular Disease risk factor using genetic and clinical information: an Artificial Neural Network perspective.
Clinical studies indicate that exaggerated postprandial lipemia is linked to the progression of atherosclerosis, leading cause of Cardiovascular Diseases (CVD). CVD is a multi-factorial disease with complex etiology and according to the literature postprandial Triglycerides (TG) can be used as an independent CVD risk factor. Aim of the current study is to construct an Artificial Neural Network (ANN) based system for the identification of the most important gene-gene and/or gene-environmental interactions that contribute to a fast or slow postprandial metabolism of TG in blood and consequently to investigate the causality of postprandial TG response. The design and development of the system is based on a dataset of 213 subjects who underwent a two meals fatty prandial protocol. For each of the subjects a total of 30 input variables corresponding to genetic variations, sex, age and fasting levels of clinical measurements were known. Those variables provide input to the system, which is based on the combined use of Parameter Decreasing Method (PDM) and an ANN. The system was able to identify the ten (10) most informative variables and achieve a mean accuracy equal to 85.21%.
Valavanis
Ioannis K
IK
School of Electrical and Computer Engineering, National Technical University of Athens, 9 Heroon Polytechneiou Str. 15780 Zographou, Greece. ivalavan@biosim.ntua.gr
Mougiakakou
Stavroula G
SG
Grimaldi
Keith A
KA
Nikita
Konstantina S
KS
D002318:Cardiovascular Diseases / Q000150:complications* / Q000175:diagnosis* / Q000235:genetics; D004777:Environment; D005215:Fasting; D005260:Female; D014644:Genetic Variation; D006801:Humans; D006949:Hyperlipidemias / Q000175:diagnosis* / Q000209:etiology* / Q000235:genetics; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D016571:Neural Networks, Computer; D019518:Postprandial Period; D015203:Reproducibility of Results; D012307:Risk Factors; D013997:Time Factors