title: Immunotherapy with combined DNA vaccines is an effective treatment for M. bovis infection in cattle.
abstract: Mycobacterium bovis causes tuberculosis in cattle. Because current therapies inadequately prevent disease spread, new therapies for M. bovis infections are urgently needed. We treated M. bovis-infected cattle with combinations of DNA vaccines, resulting in significantly reduced pulmonary bacterial loads compared with the untreated group. Further, the pathological changes of lungs were also slight and the lesions were limited in animals treated with the combined DNA vaccines, whereas untreated animals had extensive lung fibrosis and consolidated lesions. This is the first report of DNA vaccine used to treat M. bovis. Thus, combined DNA vaccines may provide enhanced immunotherapeutic efficacy for treatment of bovine tuberculosis.
authors.affiliation: The National Laboratory of Protein Engineering and Plant Genetic Engineering, Peking University, Beijing 100871, China.
authors.forename: Xi-Dan
authors.initials: XD
authors.lastname: Hu
authors.forename: Su-Ting
authors.initials: ST
authors.lastname: Chen
authors.forename: Da-Hai
authors.initials: DH
authors.lastname: Yu
authors.forename: Shu-Xia
authors.initials: SX
authors.lastname: Li
authors.forename: Hong
authors.initials: H
authors.lastname: Cai
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D003001:Cloning, Molecular; D007167:Immunotherapy / Q000379:methods / Q000662:veterinary; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D008171:Lung Diseases / Q000276:immunology / Q000473:pathology / Q000662:veterinary; D009163:Mycobacterium bovis / Q000235:genetics / Q000276:immunology*; D014374:Tuberculin Test; D014380:Tuberculosis, Bovine / Q000276:immunology*; D019444:Vaccines, DNA / Q000627:therapeutic use*
chemical_list: D001428:Bacterial Vaccines; D019444:Vaccines, DNA