Animal studies supporting the inhibition of mast cell activation by Eriobotrya japonica seed extract.
OBJECTIVE
The potent antioxidant activity of Eriobotrya japonica seed extract (ESE) and its usefulness in the prevention and treatment of various disorders has been reported previously. Its antioxidant activity associated with beta-sitosterol and polyphenols contained in the extract was also validated. In this study, anti-allergic activity of Eriobotrya japonica seed extract was investigated.


METHODS
The inhibition of histamine release-mediated type 1 allergy by Eriobotrya japonica seed extract was used as an index.


RESULTS
The administration of this extract inhibited histamine release from rat mast cells, suggesting its usefulness in allergic disease treatment. In an experiment using a guinea-pig allergic rhinitis model, this extract reduced the frequency of sneezing and nose-scratching.


CONCLUSIONS
These results suggest that Eriobotrya japonica seed extract may contribute to the relief of allergic disease-related symptoms.
Onogawa
Masahide
M
Department of Biomedical Science, Kochi Medical Graduate School, Kochi, Japan. jm-ma_ono@kochi-u.ac.jp
Sun
Guangchen
G
Takuma
Daisuke
D
Hamada
Atsuhide
A
Yokota
Junko
J
Yoshioka
Saburo
S
Kusunose
Masahiko
M
Miyamura
Mitsuhiko
M
Kyotani
Shojiro
S
Nishioka
Yutaka
Y
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D031983:Eriobotrya / Q000737:chemistry*; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000032:analysis / Q000378:metabolism; D008297:Male; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D010529:Peritoneal Cavity / Q000166:cytology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D012221:Rhinitis, Allergic, Perennial / Q000517:prevention & control; D006255:Rhinitis, Allergic, Seasonal / Q000517:prevention & control; D012639:Seeds / Q000737:chemistry; D012867:Skin / Q000098:blood supply / Q000187:drug effects; D012912:Sneezing / Q000187:drug effects
D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase