Human papillomaviruses: a growing field.
A combination of functional studies on human papillomavirus (HPV) oncoproteins and epidemiological studies on persistence of HPV infection firmly established a role for HPV in the etiology of cervical cancers. Understanding the viral life cycle of HPVs has been more difficult. In this issue of Genes & Development, Wang et al. (pp. 181 - 194) describe an efficient method to propagate infectious HPV in differentiating epithelium, providing clear evidence for temporal separation of viral and cellular replication.
Galloway
Denise A
DA
Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA. dgallowa@fhcrc.org
D046508:Culture Techniques; D004848:Epithelium / Q000821:virology; D016195:G2 Phase; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics / Q000502:physiology*; D030361:Papillomavirus Infections / Q000378:metabolism / Q000821:virology; D016196:S Phase; D014759:Viral Envelope Proteins / Q000378:metabolism; D014779:Virus Replication
D014759:Viral Envelope Proteins