title: A mineral trioxide aggregate sealer stimulated mineralization.
abstract: The aim of this study was to evaluate the rat subcutaneous tissue response to implanted polyethylene tubes filled with Endo-CPM-Sealer (Portland Cement Modified Sealer) (EGEO S.R.L., Buenos Aires, Argentina) compared with Sealapex (SybronEndo, Glendora, CA) and Angelus MTA (Angelus, Londrina, Brazil). These materials were placed in polyethylene and dentin tubes and implanted into dorsal connective tissue of Wistar rats for 7, 15, 30, 60, and 90 days. The specimens were prepared to be stained with hematoxylin and eosin or Von Kossa or not stained for polarized light. Qualitative and quantitative evaluations of the reaction were performed. Both materials caused mild to moderate reactions at 7 days that decreased with time. The response was similar to the control on the 30th day with Endo-CPM-Sealer and Angelus MTA and on the 60th day with Sealapex. Mineralization and granulations birefringent to the polarized light were observed with all materials. It was possible to conclude that Endo-CPM-Sealer was biocompatible and stimulated mineralization.
authors.affiliation: Department of Endodontics, Araçatuba School of Dentistry, São Paulo State University, São Paulo, Brazil. joao@foa.unesp.br
authors.forename: João Eduardo
authors.initials: JE
authors.lastname: Gomes-Filho
authors.forename: Simone
authors.initials: S
authors.lastname: Watanabe
authors.forename: Pedro Felício Estrada
authors.initials: PF
authors.lastname: Bernabé
authors.forename: Mariana Teixeira
authors.initials: MT
authors.lastname: de Moraes Costa
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry / Q000633:toxicity*; D000818:Animals; D002119:Calcium Carbonate; D017610:Calcium Compounds / Q000737:chemistry / Q000633:toxicity*; D002126:Calcium Hydroxide / Q000633:toxicity; D003809:Dentin, Secondary / Q000378:metabolism*; D004338:Drug Combinations; D007249:Inflammation / Q000139:chemically induced; D008297:Male; D008422:Materials Testing; D010087:Oxides / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000737:chemistry / Q000633:toxicity*; D012459:Salicylates / Q000633:toxicity; D017640:Silicates / Q000737:chemistry / Q000633:toxicity*; D040521:Subcutaneous Tissue / Q000187:drug effects; D013997:Time Factors
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; C540763:Endo-CPM-Sealer; D010087:Oxides; D012387:Root Canal Filling Materials; D012459:Salicylates; D017640:Silicates; C086631:mineral trioxide aggregate; C055601:Sealapex; D002119:Calcium Carbonate; D002126:Calcium Hydroxide