Relaying the checkpoint signal from kinetochore to APC/C.
The mitotic checkpoint delays chromosome segregation until the last chromosome has correctly attached to the spindle. Exactly how this unattached chromosome can generate a checkpoint signal and inhibit the anaphase promoting complex/cyclosome (APC/C) is unknown. Two Developmental Cell papers in this issue by Kulukian et al. and Malureanu et al. now provide insight into how checkpoint components Mad2 and BubR1 relay the checkpoint signal from kinetochores to APC/C.
Medema
René H
RH
Department of Medical Oncology and Cancer Genomics Center, University Medical Center Utrecht, Utrecht, the Netherlands. r.h.medema@umcutrecht.nl
D064173:Anaphase-Promoting Complex-Cyclosome; D018797:Cell Cycle Proteins / Q000378:metabolism*; D020090:Chromosome Segregation; D002875:Chromosomes / Q000378:metabolism; D018386:Kinetochores / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
D018797:Cell Cycle Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome