title: A novel class of allosteric modulators of AMPA/Kainate receptors.
abstract: The rapid hydrolysis in vivo of IDRA21 to 2-amino-5-chlorobenzensulfonamide has been demonstrated by microdialysis experiments. The IDRA21 metabolite possess in vitro a biological activity similar to that of IDRA21 itself. Taking 2-amino-5-chlorobenzensulfonamide as lead compound, a novel class of AMPAR positive allosteric modulators has been prepared.
authors.affiliation: Department of Pharmaceutical Science, University of Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy. giuseppe.cannazza@unimo.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cannazza
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Jozwiak
authors.forename: Carlo
authors.initials: C
authors.lastname: Parenti
authors.forename: Daniela
authors.initials: D
authors.lastname: Braghiroli
authors.forename: Marina M
authors.initials: MM
authors.lastname: Carrozzo
authors.forename: Giulia
authors.initials: G
authors.lastname: Puia
authors.forename: Gabriele
authors.initials: G
authors.lastname: Losi
authors.forename: Mario
authors.initials: M
authors.lastname: Baraldi
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lindner
authors.forename: Irving W
authors.initials: IW
authors.lastname: Wainer
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001581:Benzothiadiazines / Q000737:chemistry / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D006624:Hippocampus / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats; D018091:Receptors, AMPA / Q000187:drug effects*; D018092:Kainic Acid Receptors / Q000187:drug effects*; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000096926:Benzenesulfonamides
chemical_list: D001581:Benzothiadiazines; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D013449:Sulfonamides; D000096926:Benzenesulfonamides; C538710:2-amino-5-chlobenzensulfonamide; C091420:IDRA 21