title: Anxiety disorders and rheumatic Fever: is there an association?
abstract: BACKGROUND
  Findings suggest that obsessive-compulsive disorder (OCD) and related disorders, referred to as obsessive-compulsive spectrum disorders (OCSDs), are more common in patients with rheumatic fever (RF).
  
  
  OBJECTIVE
  To determine whether RF or Sydenham's chorea increases the probability of anxiety disorders in the relatives of individuals with RF with and without SC.
  
  
  METHODS
  This was a case-control family study in which 98 probands and 389 first-degree relatives (FDRs) were assessed using structured psychiatric interviews. A Poisson regression model was used to determine whether the presence of any disorder in one family member influences the rate of disorders in the remaining family members.
  
  
  RESULTS
  Generalized anxiety disorder (GAD) occurred more frequently in the FDRs of RF probands than in those of control probands (P=.018). The presence of RF, GAD, or separation anxiety disorder in one family member significantly increased the chance of OCSDs in another member of the family.
  
  
  CONCLUSIONS
  We found familial aggregation among RF, GAD, and OCSDs. Clinicians should be aware of the possible familial relationship between GAD and OCSDs in their RF patients and their family members, which may suggest a genetic component between them. Further studies on OCD should include anxiety disorders to better define OCD spectrum.
authors.affiliation: Department of Psychiatry, University of São Paulo Medical School, Brazil. anah@protoc.com.br
authors.forename: A Augusto Anderson
authors.initials: AA
authors.lastname: Seixas
authors.forename: Ana G
authors.initials: AG
authors.lastname: Hounie
authors.forename: Victor
authors.initials: V
authors.lastname: Fossaluza
authors.forename: Mariana
authors.initials: M
authors.lastname: Curi
authors.forename: Pedro G
authors.initials: PG
authors.lastname: Alvarenga
authors.forename: Maria A
authors.initials: MA
authors.lastname: De Mathis
authors.forename: Maria E
authors.initials: ME
authors.lastname: De Mathis
authors.forename: Homero
authors.initials: H
authors.lastname: Vallada
authors.forename: David
authors.initials: D
authors.lastname: Pauls
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: de Bragança Pereira
authors.forename: Eurípedes C
authors.initials: EC
authors.lastname: Miguel
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology*; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D015897:Comorbidity; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D012044:Regression Analysis; D012213:Rheumatic Fever / Q000175:diagnosis / Q000453:epidemiology*