title: Pharmacodynamics and pharmacokinetics studies of phenoxazinium derivatives for antimalarial agent.
abstract: In vivo antimalarial drug candidates screening test was carried out on a series of water-soluble 3,7-bis(dialkylamino)phenoxazin-5-ium derivatives. Among them, 3-(diethylamino)-7-(piperidin-1-yl)phenoxazin-5-ium chloride (SSJ-206) showing highest efficacy was chosen for further pharmcodynamics and pharmacokinetics study. It was supported from these data that the phenoxazinium salts, SSJ-206, would be one of hopeful candidates as an oral antimalarial drug.
authors.affiliation: Research Centre of Medicinal Sciences, Hoshi University, Shinagawa, Tokyo, Japan.
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Ge
authors.forename: Chika
authors.initials: C
authors.lastname: Arai
authors.forename: Isamu
authors.initials: I
authors.lastname: Itoh
authors.forename: Qiang
authors.initials: Q
authors.lastname: Fu
authors.forename: Masataka
authors.initials: M
authors.lastname: Ihara
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology*; D005260:Female; D008288:Malaria / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010078:Oxazines / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics* / Q000494:pharmacology*; D021261:Parasitic Sensitivity Tests; D010962:Plasmodium berghei / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D010078:Oxazines