[Comparison of the changes in blood glucose levels during anesthetic management using sevoflurane and propofol].
BACKGROUND
Recent studies have shown that sevoflurane impairs glucose tolerance, but the effect of propofol on glucose metabolism is not still clear.


METHODS
Two hundred and seventeen patients were enrolled in this retrospective study. Patients were classified into two groups according to anesthetic agent used for maintenance of general anesthesia; sevoflurane group (n = 154) and propofol group (n = 63). Changes in blood glucose levels were compared between the two groups in four periods during anesthetic management ; within 1 hour, 1-2 hour, 2-3 hour, 3-4 hour after the induction of general anesthesia.


RESULTS
The two groups were comparable with regard to patients' age, gender, height, weight, and American Society of Anesthesiologists physical status. In all time periods, blood glucose level in sevoflurane group was significantly higher than that in propofol group.


CONCLUSIONS
Results in this study imply that the effect on glucose metabolism of propofol is much less than that of sevoflurane.
Kitamura
Takayuki
T
Department of Anesthesiology, Faculty of Medicine, The University of Tokyo, Tokyo 113-8655.
Kawamura
Gaku
G
Ogawa
Makoto
M
Yamada
Yoshitsugu
Y
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001786:Blood Glucose; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008738:Methyl Ethers / Q000009:adverse effects; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects; D012189:Retrospective Studies; D000077149:Sevoflurane; D013997:Time Factors
D001786:Blood Glucose; D008738:Methyl Ethers; D000077149:Sevoflurane; D015742:Propofol