Synthetic medicinal chemistry of selected antimalarial natural products.
Natural products remain a rich source of novel molecular scaffolds for novel antimalarial agents in the fight against malaria. This has been well demonstrated in the case of quinine and artemisinin both of which have served as templates for the development of structurally simpler analogues that either served or continue to serve as effective antimalarials. This review will expound on these two natural products as well as other selected natural products that have served either as antimalarial agents or as potential lead compounds in the development of antimalarial drugs.
Kumar
Vipan
V
Department of Chemistry, University of Cape Town, Private Bag, Rondebosh 7701, South Africa.
Mahajan
Aman
A
Chibale
Kelly
K
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D006801:Humans
D000962:Antimalarials; D001688:Biological Products