Muscle Research and Gene Ontology: New standards for improved data integration.
BACKGROUND
The Gene Ontology Project provides structured controlled vocabularies for molecular biology that can be used for the functional annotation of genes and gene products. In a collaboration between the Gene Ontology (GO) Consortium and the muscle biology community, we have made large-scale additions to the GO biological process and cellular component ontologies. The main focus of this ontology development work concerns skeletal muscle, with specific consideration given to the processes of muscle contraction, plasticity, development, and regeneration, and to the sarcomere and membrane-delimited compartments. Our aims were to update the existing structure to reflect current knowledge, and to resolve, in an accommodating manner, the ambiguity in the language used by the community.


RESULTS
The updated muscle terminologies have been incorporated into the GO. There are now 159 new terms covering critical research areas, and 57 existing terms have been improved and reorganized to follow their usage in muscle literature.


CONCLUSIONS
The revised GO structure should improve the interpretation of data from high-throughput (e.g. microarray and proteomic) experiments in the area of muscle science and muscle disease. We actively encourage community feedback on, and gene product annotation with these new terms. Please visit the Muscle Community Annotation Wiki http://wiki.geneontology.org/index.php/Muscle_Biology.
Feltrin
Erika
E
CRIBI- Interdepartmental Biotechnology Center, University of Padua, Padua, Italy. erika@cribi.unipd.it
Campanaro
Stefano
S
Diehl
Alexander D
AD
Ehler
Elisabeth
E
Faulkner
Georgine
G
Fordham
Jennifer
J
Gardin
Chiara
C
Harris
Midori
M
Hill
David
D
Knoell
Ralph
R
Laveder
Paolo
P
Mittempergher
Lorenza
L
Nori
Alessandra
A
Reggiani
Carlo
C
Sorrentino
Vincenzo
V
Volpe
Pompeo
P
Zara
Ivano
I
Valle
Giorgio
G
Deegan
Jennifer
J