Health-related quality of life in adult survivors of childhood sarcoidosis.
OBJECTIVE
To describe health-related quality of life (hrQOL) in adult subjects who had sarcoidosis in childhood.


METHODS
Forty-six children (24 boys), all ethnic Danes <or=15 years of age with sarcoidosis were recorded in Denmark in 1979-1994. Three patients were deceased prior to this study. At follow-up, the 43 surviving adult subjects were invited to complete the short-form health survey questionnaire SF-36, being completed by 34 subjects (14 men). SF-36 scores were compared with the scores in the Danish reference population.


RESULTS
At follow-up, 30/34 patients had recovered from sarcoidosis and 4/34 patients had persistent chronic active disease with impaired lung function. SF-36 scores in all domains were similar to scores in the reference population; the four patients with chronic active disease had lower scores in three domains. In the entire series, physical component summary (PCS) score and mental component summary (MCS) score was similar to the reference population.


CONCLUSIONS
Childhood sarcoidosis has a favourable prognosis concerning health status in adulthood. The majority of adult subjects had a health status that was indistinguishable from a healthy reference population.
Milman
Nils
N
The Heart Centre, Division of Lung Transplantation, Rigshospitalet, University of Copenhagen, Denmark. nils.mil@dadlnet.dk
Svendsen
Claus Bo
CB
Hoffmann
Anne Lisbeth
AL
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003718:Denmark / Q000453:epidemiology; D004812:Epidemiologic Methods; D006304:Health Status; D006801:Humans; D008297:Male; D011379:Prognosis; D011788:Quality of Life; D011859:Radiography; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000150:complications / Q000000981:diagnostic imaging / Q000453:epidemiology*; D017741:Survivors; D055815:Young Adult