title: Survival after massive hydroxychloroquine overdose.
abstract: Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning (20 g in each case), both of which received advanced cardiac life support and a treatment regimen consisting of sodium bicarbonate, adrenaline and potassium. Both these patients survived beyond their initial rapid deterioration and cardiovascular collapse to be discharged from hospital without sequelae. These patients had the highest reported non-lethal serum concentrations (13.8 and 26.0 mg/l). They both demonstrated rapid recovery from a pre-arrest condition, following aggressive correction of electrolyte and pH disturbance and rapid distribution of the drug to peripheral tissues.
authors.affiliation: New South Wales Poisons Information Centre, The Children's Hospital at Westmead, Sydney, New South Wales, Australia.
authors.forename: N
authors.initials: N
authors.lastname: Gunja
authors.forename: D
authors.initials: D
authors.lastname: Roberts
authors.forename: D
authors.initials: D
authors.lastname: McCoubrie
authors.forename: P
authors.initials: P
authors.lastname: Lamberth
authors.forename: A
authors.initials: A
authors.lastname: Jan
authors.forename: D C
authors.initials: DC
authors.lastname: Simes
authors.forename: P
authors.initials: P
authors.lastname: Hackett
authors.forename: N A
authors.initials: NA
authors.lastname: Buckley
mesh_terms: D000293:Adolescent; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000506:poisoning*; D062787:Drug Overdose / Q000628:therapy; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000506:poisoning*; D008875:Middle Aged; D013406:Suicide, Attempted; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D006886:Hydroxychloroquine