title: Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.
abstract: CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type I (Valpha14i) and type II (non-Valpha14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells.
authors.affiliation: Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
authors.forename: Michael I
authors.initials: MI
authors.lastname: Zimmer
authors.forename: Hanh P
authors.initials: HP
authors.lastname: Nguyen
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Honglin
authors.initials: H
authors.lastname: Xu
authors.forename: Angela
authors.initials: A
authors.lastname: Colmone
authors.forename: Kyrie
authors.initials: K
authors.lastname: Felio
authors.forename: Hak-Jong
authors.initials: HJ
authors.lastname: Choi
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Maria-Luisa
authors.initials: ML
authors.lastname: Alegre
authors.forename: Chyung-Ru
authors.initials: CR
authors.lastname: Wang
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000235:genetics*; D055610:Antigens, CD1d / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics*; D051379:Mice; D020297:Mice, Congenic; D011110:Polymorphism, Genetic; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D055610:Antigens, CD1d