A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation.
In our screening for translocase I inhibitors, we found the novel nucleoside antibiotic, A-94964 in the culture broth of Streptomyces sp. SANK 60404. The structure of A-94964 was elucidated primarily by various NMR studies, including a 1H-31P HMBC experiment. A-94964 has a unique structure which possesses a nucleoside moiety and an N-acylglucosamine moiety connected via a phosphate.
Fujita
Yoko
Y
Exploratory Research Laboratories I, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. fujita.yoko.x8@daiichisankyo.co.jp
Murakami
Ryo
R
Muramatsu
Yasunori
Y
Miyakoshi
Shunichi
S
Takatsu
Toshio
T
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001419:Bacteria / Q000201:enzymology*; D004187:Disaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011742:Pyrimidine Nucleotides / Q000737:chemistry*; D013302:Streptomyces / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000037:antagonists & inhibitors*
C535078:A 94964; D000900:Anti-Bacterial Agents; D004187:Disaccharides; D011742:Pyrimidine Nucleotides; D017855:Transferases (Other Substituted Phosphate Groups); C100130:phospho-N-acetylmuramoyl pentapeptide transferase