title: CORNA: testing gene lists for regulation by microRNAs.
abstract: BACKGROUND
  With the increasing use of post-genomics techniques to examine a wide variety of biological systems in laboratories throughout the world, scientists are often presented with lists of genes that they must make sense of. A consistently challenging problem is that of defining co-regulated genes within those gene lists. In recent years, microRNAs have emerged as a mechanism for regulating several cellular processes. In this article, we report on how gene lists and microRNA targets data may be integrated to test for significant associations between gene lists and microRNAs.
  
  
  RESULTS
  We discuss CORNA, a package written in R and released under the GNU GPL, which allows users to test gene lists for significant microRNA-target associations using one of three separate statistical tests, to link microRNA targets to functional annotation and to visualize quantitative data associated with those data.
  
  
  BACKGROUND
  CORNA is available as an R package from http://corna.sf.net.
authors.affiliation: Bioinformatics Group, Institute for Animal Health, Compton, RG20 7NN, UK. xikun.wu@bbsrc.ac.uk
authors.forename: X
authors.initials: X
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Watson
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D005786:Gene Expression Regulation; D023281:Genomics / Q000379:methods; D035683:MicroRNAs / Q000378:metabolism*; D012984:Software
chemical_list: D035683:MicroRNAs