title: The International Testicular Cancer Linkage Consortium: a clinicopathologic descriptive analysis of 461 familial malignant testicular germ cell tumor kindred.
abstract: OBJECTIVE
  Familial aggregation of testicular germ cell tumor (TGCT) has been reported, but it is unclear if familial TGCT represents a unique entity with distinct clinicopathologic characteristics. Here we describe a collection of familial TGCT cases from an international consortium, in an effort to elucidate any clinical characteristics that are specific to this population.
  
  
  METHODS
  Families with >or=2 cases of TGCT enrolled at 18 of the sites participating in the International Testicular Cancer Linkage Consortium were included. We analyzed clinicopathologic characteristics of 985 cases from 461 families.
  
  
  RESULTS
  A majority (88.5%) of families had only 2 cases of TGCT. Men with seminoma (50% of cases) had an older mean age at diagnosis than nonseminoma cases (P = 0.001). Among individuals with a history of cryptorchidism, TGCT was more likely to occur in the ipsilateral testis (kappa = 0.65). Cousin pairs appeared to represent a unique group, with younger age at diagnosis and a higher prevalence of cryptorchidism than other families.
  
  
  CONCLUSIONS
  Clinicopathologic characteristics in these familial TGCT cases were similar to those generally described for nonfamilial cases. However, we observed a unique presentation of familial TGCT among cousin pairs. Additional studies are needed to further explore this observation.
authors.affiliation: Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA. maip@mail.nih.gov
authors.forename: Phuong L
authors.initials: PL
authors.lastname: Mai
authors.forename: Michael
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authors.lastname: Friedlander
authors.forename: Kathy
authors.initials: K
authors.lastname: Tucker
authors.forename: Kelly-Anne
authors.initials: KA
authors.lastname: Phillips
authors.forename: David
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authors.lastname: Hogg
authors.forename: Michael A S
authors.initials: MA
authors.lastname: Jewett
authors.forename: Radka
authors.initials: R
authors.lastname: Lohynska
authors.forename: Gedske
authors.initials: G
authors.lastname: Daugaard
authors.forename: Stéphane
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authors.lastname: Richard
authors.forename: Catherine
authors.initials: C
authors.lastname: Bonaïti-Pellié
authors.forename: Axel
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authors.lastname: Heidenreich
authors.forename: Peter
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authors.lastname: Albers
authors.forename: Istvan
authors.initials: I
authors.lastname: Bodrogi
authors.forename: Lajos
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authors.lastname: Geczi
authors.forename: Edith
authors.initials: E
authors.lastname: Olah
authors.forename: Peter A
authors.initials: PA
authors.lastname: Daly
authors.forename: Parry
authors.initials: P
authors.lastname: Guilford
authors.forename: Sophie D
authors.initials: SD
authors.lastname: Fosså
authors.forename: Ketil
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authors.lastname: Heimdal
authors.forename: Ludmila
authors.initials: L
authors.lastname: Liubchenko
authors.forename: Sergei A
authors.initials: SA
authors.lastname: Tjulandin
authors.forename: Hans
authors.initials: H
authors.lastname: Stoll
authors.forename: Walter
authors.initials: W
authors.lastname: Weber
authors.forename: Douglas F
authors.initials: DF
authors.lastname: Easton
authors.forename: Darshna
authors.initials: D
authors.lastname: Dudakia
authors.forename: Robert
authors.initials: R
authors.lastname: Huddart
authors.forename: Michael R
authors.initials: MR
authors.lastname: Stratton
authors.forename: Lawrence
authors.initials: L
authors.lastname: Einhorn
authors.forename: Larissa
authors.initials: L
authors.lastname: Korde
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Nathanson
authors.forename: D Timothy
authors.initials: DT
authors.lastname: Bishop
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rapley
authors.forename: Mark H
authors.initials: MH
authors.lastname: Greene
mesh_terms: D000328:Adult; D003456:Cryptorchidism / Q000235:genetics; D006552:Hernia, Inguinal / Q000235:genetics; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics* / Q000473:pathology*; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology*