title: Sentinel lymphadenectomy for the staging of clinical axillary node-negative breast cancer before neoadjuvant chemotherapy.
abstract: BACKGROUND
  Several authors reported sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NC). Nevertheless, the ideal time of SLNB is still a matter of debate.
  
  
  METHODS
  We evaluated the feasibility and the accuracy of SLNB before NC using a combined procedure (blue dye and radio-labelled detection) before NC. Axillary lymph node dissection (ALND) was performed after completion of NC in a homogeneous cohort study with clinically axillary node-negative breast cancer.
  
  
  RESULTS
  Among the 20 women who had metastatic SLNB (65%), 4 (20%) had additional metastatic node on ALND. By contrast, all the 11 women who had no metastatic SLNB had no involved nodes in the ALND. The SLN identification rate before NC was 100% with any false negative.
  
  
  CONCLUSIONS
  SLNB before NC is a feasible and an accurate diagnostic tool to predict the pre-therapeutic axilla status. These findings suggest that ALND may be avoided in patients with a negative SLNB performed before NC.
authors.affiliation: Department of Surgery, Institut Paoli-Calmettes, Regional Cancer Center, 232 Bvd, Sainte Margueritte, 13273 Marseille Cedex 9, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Menard
authors.forename: J-M
authors.initials: JM
authors.lastname: Extra
authors.forename: J
authors.initials: J
authors.lastname: Jacquemier
authors.forename: M
authors.initials: M
authors.lastname: Buttarelli
authors.forename: E
authors.initials: E
authors.lastname: Lambaudie
authors.forename: M
authors.initials: M
authors.lastname: Bannier
authors.forename: I
authors.initials: I
authors.lastname: Brenot Rossi
authors.forename: G
authors.initials: G
authors.lastname: Houvenaeghel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005240:Feasibility Studies; D005260:Female; D005602:France; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D012680:Sensitivity and Specificity; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D013997:Time Factors