Synthesis of thiazolo- and 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles.
The first examples of thiazolo[4,5-e]benzoisoxazoles are obtained from bromination of dihydrobenzo[d]isoxazol-4(5H)-one followed by cyclocondensation with thiourea, in the presence of DDQ. Analogously, cyclocondensation with thioamides provided 7,8-dihydrothiazolo[4,5-e]benzoisoxazoles. A 55-member library of these heterocycles is reported.
El-Badri
M H
MH
Department of Chemistry, One Shields Avenue, University of California, Davis, California 95616, USA.
Kurth
Mark J
MJ
D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D054879:Halogenation; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry
D001555:Benzene Derivatives; D007555:Isoxazoles; D013844:Thiazoles