title: Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis.
abstract: BACKGROUND
  The neuroselective transcutaneous electrical stimulator (NTES) can provoke itch and/or pain by the application of a 5-Hz alternating current.
  
  
  OBJECTIVE
  We sought to examine whether there is any difference in the perception of the stimulus evoked by the NTES between patients with atopic dermatitis (AD) and healthy control subjects.
  
  
  METHODS
  In all, 24 healthy control subjects and 24 patients with AD (nonlesional skin) were stimulated on 7 body sites using the NTES. Qualitative differences in the evoked perceptions and quantitative differences in the current intensity required to evoke perception were statistically analyzed.
  
  
  RESULTS
  The NTES preferentially evoked itch in patients with AD. The current perception threshold was statistically lower in AD than in healthy control subjects on 3 body sites.
  
  
  CONCLUSIONS
  Tests were performed on limited body areas.
  
  
  CONCLUSIONS
  We demonstrated that the NTES can reveal neuronal sensitization to itch in nonlesional atopic skin.
authors.affiliation: Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Tsuchiyama
authors.forename: Rumiko
authors.initials: R
authors.lastname: Gomi
authors.forename: Fumio
authors.initials: F
authors.lastname: Kurosaki
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kawamoto
authors.forename: Setsuya
authors.initials: S
authors.lastname: Aiba
mesh_terms: D003876:Dermatitis, Atopic / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D009420:Nervous System / Q000503:physiopathology; D009474:Neurons; D010146:Pain / Q000503:physiopathology; D011537:Pruritus / Q000503:physiopathology; D004561:Transcutaneous Electric Nerve Stimulation / Q000379:methods; D055815:Young Adult