title: Polymorphism in MRL and AKR mice Sry: a candidate gene for the appearance of testicular oocyte.
abstract: Although mammals produce either sperm or eggs depending on their sex, newborn MRL/MpJ male mice contain oocytes within their testes. In our previous study, the testicular oocyte appears as early as day 0 afterbirth and has morphological characteristics as an oocyte such as zona pellucida and follicular epithelial cells. Based on the observation of F1 between MRL/MpJ and C57BL/6, one of the genes causing the appearance of testicular oocyte exists on the Y chromosome. In the present study, we found testicular oocytes within newborn AKR mice. Wehave also analyzed the Sry genes from several inbred mouse strains and identified a shortened glutamine repeat near the C-terminal region that is unique to MRL and AKR. These results suggest that polymorphism of glutamine repeat within SRY correlates with the appearance of testicular oocyte and this phenotype is derived from AKR, one of the original strains of MRL mice.
authors.affiliation: Laboratory of Anatomy, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060-0818, Japan.
authors.forename: Saori
authors.initials: S
authors.lastname: Otsuka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Konno
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Nobuya
authors.initials: N
authors.lastname: Sasaki
authors.forename: Daiji
authors.initials: D
authors.lastname: Endoh
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kon
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D001483:Base Sequence; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D009865:Oocytes / Q000502:physiology* / Q000648:ultrastructure; D011110:Polymorphism, Genetic; D051876:Sex-Determining Region Y Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D013737:Testis / Q000166:cytology*
chemical_list: D051876:Sex-Determining Region Y Protein; C497746:Sry protein, mouse