title: A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment.
abstract: Cryptococcal pleuritis is rare in individuals with no underlying disease. We report a case of pulmonary cryptococcosis followed by pleuritis in a patient on fluconazole treatment. Biopsy of the pleura revealed a granuloma and a cryptococcal body, while PCR and sequence analysis of extracted DNA from the pleura proved the presence of Cryptococcus species, most likely C. neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. koizumik@nagasaki-u.ac.jp
authors.forename: Koichi
authors.initials: K
authors.lastname: Izumikawa
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Kohei
authors.initials: K
authors.lastname: Motoshima
authors.forename: Takahiro
authors.initials: T
authors.lastname: Takazono
authors.forename: Tomomi
authors.initials: T
authors.lastname: Saijo
authors.forename: Sintaro
authors.initials: S
authors.lastname: Kurihara
authors.forename: Shigeki
authors.initials: S
authors.lastname: Nakamura
authors.forename: Taiga
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Seki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kakeya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yanagihara
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Miyazaki
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D000328:Adult; D001483:Base Sequence; D003453:Cryptococcosis / Q000188:drug therapy / Q000382:microbiology*; D003455:Cryptococcus neoformans / Q000235:genetics / Q000302:isolation & purification*; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects*; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008969:Molecular Sequence Data; D010998:Pleurisy / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D016415:Sequence Alignment
chemical_list: D015725:Fluconazole