title: Inability of healthy subjects to deposit potassium during hypokinesia and potassium supplementation.
abstract: OBJECTIVE
  To determine the effect of potassium (K+) supplementation and hypokinesia (HK; diminished movement) on muscle K+ content and K+ loss.
  
  
  METHODS
  Studies were conducted on 40 healthy male volunteers during a pre-experimental period of 30 days and an experimental-period of 364 days. Volunteers were equally divided into four groups: unsupplemented control subjects (UCS), unsupplemented experimental subjects (UES), supplemented control subjects (SCS), and supplemented experimental subjects (SES). A daily supplement of 1.17 mmol potassium-chloride (KCl) per kg body weight was given to the subjects in the SCS and SES groups.
  
  
  RESULTS
  Muscle K+ content decreased (P < 0.05), and plasma K+ concentration, and K+ loss in urine and feces increased (P < 0.05) in the SES and UES groups compared with their pre-experimental levels and the values in their respective control groups (SCS and UCS). Muscle K+ content decreased more (P < 0.05), and plasma K+ concentration and K+ loss in urine and feces increased more (P < 0.05) in the SES group than in the UES group.
  
  
  CONCLUSIONS
  Muscle K+ content is not decreased by the K+ deficient diet and K+ loss is not increased by the higher muscle K+ content in the body. Rather it is caused by the inability of the body to use K+ during HK and K+ supplementation.
authors.affiliation: Hypokinetic Biochemistry Laboratory, Sofia, Bulgaria.
authors.forename: Yan G
authors.initials: YG
authors.lastname: Zorbas
authors.forename: Kostas K
authors.initials: KK
authors.lastname: Kakuris
authors.forename: Yuri F
authors.initials: YF
authors.lastname: Federenko
authors.forename: Viktor A
authors.initials: VA
authors.lastname: Deogenov
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D005243:Feces; D006801:Humans; D018476:Hypokinesia / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000378:metabolism; D011188:Potassium / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine; D012016:Reference Values
chemical_list: D011188:Potassium