title: Role of estrogen receptor alpha in membrane-initiated signaling in neural cells: interaction with IGF-1 receptor.
abstract: The mechanisms of action of estradiol in the nervous system involve nuclear-initiated steroid signaling and membrane-initiated steroid signaling. Estrogen receptors (ERs) are involved in both mechanisms. ERalpha interacts with the signaling of IGF-1 receptor in neural cells: ERalpha transcriptional activity is regulated by IGF-1 receptor signaling and estradiol regulates IGF-1 receptor signaling. The interaction between ERalpha and the IGF-1 receptor in the brain may occur at the plasma membrane of neurons and glial cells. Caveolin-1 may provide the scaffolding for the interaction of different membrane-associated molecules, including voltage-dependent anion channel, ERalpha and IGF-I receptor.
authors.affiliation: Laboratory of Cellular Neurobiology, Department of Physiology & Institute of Biomedical Technologies, University of La Laguna, School of Medicine, Santa Cruz de Tenerife, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Marin
authors.forename: Mario
authors.initials: M
authors.lastname: Díaz
authors.forename: Rafael
authors.initials: R
authors.lastname: Alonso
authors.forename: Amaya
authors.initials: A
authors.lastname: Sanz
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Arévalo
authors.forename: Luis M
authors.initials: LM
authors.lastname: Garcia-Segura
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D047628:Estrogen Receptor alpha; D017526:Receptor, IGF Type 1