Functional and biocompatibility performances of an integrated Maglev pump-oxygenator.
To provide respiratory support for patients with lung failure, a novel compact integrated pump-oxygenator is being developed. The functional and biocompatibility performances of this device are presented. The pump-oxygenator is designed by combining a magnetically levitated pump/rotor with a uniquely configured hollow fiber membrane bundle to create an assembly free, ultracompact, all-in-one system. The hemodynamics, gas transfer and biocompatibility performances of this novel device were investigated both in vitro in a circulatory flow loop and in vivo in an ovine animal model. The in vitro results showed that the device was able to pump blood flow from 2 to 8 L/min against a wide range of pressures and to deliver an oxygen transfer rate more than 300 mL/min at a blood flow of 6 L/min. Blood damage tests demonstrated low hemolysis (normalized index of hemolysis [NIH] approximately 0.04) at a flow rate of 5 L/min against a 100-mm Hg afterload. The data from five animal experiments (4 h to 7 days) demonstrated that the device could bring the venous blood to near fully oxygen-saturated condition (98.6% +/- 1.3%). The highest oxygen transfer rate reached 386 mL/min. The gas transfer performance was stable over the study duration for three 7-day animals. There was no indication of blood damage. The plasma free hemoglobin and platelet count were within the normal ranges. No gross thrombus is found on the explanted pump components and fiber surfaces. Both in vitro and in vivo results demonstrated that the newly developed pump-oxygenator can achieve sufficient blood flow and oxygen transfer with excellent biocompatibility.
Zhang
Tao
T
Artificial Organs Laboratory, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Cheng
Guangming
G
Koert
Andrew
A
Zhang
Juntao
J
Gellman
Barry
B
Yankey
G Kwame
GK
Satpute
Aditee
A
Dasse
Kurt A
KA
Gilbert
Richard J
RJ
Griffith
Bartley P
BP
Wu
Zhongjun J
ZJ
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004867:Equipment Design; D008280:Magnetics; D008422:Materials Testing; D010100:Oxygen / Q000097:blood; D010107:Oxygenators, Membrane; D012756:Sheep
D002245:Carbon Dioxide; D010100:Oxygen