title: Acute D-psicose administration decreases the glycemic responses to an oral maltodextrin tolerance test in normal adults.
abstract: An examination was conducted to verify D-psicose suppressed the elevation of blood glucose and insulin concentration in a dose-dependent manner under the concurrent administration of maltodextrin and D-psicose to healthy humans. Twenty subjects aged 20-39 y, 11 males and 9 females were recruited. A load test of oral maltodextrin was conducted as a randomized single blind study. The subjects took one of five test beverages (7.5 g D-psicose alone, 75 g maltodextrin alone, 75 g maltodextrin +2.5, 5 or 7.5 g D-psicose). Blood was collected before an intake and at 30, 60, 90 and 120 min after an intake. Intervals of administration were at least 1 wk. The load test with 75 g maltodextrin showed significant suppressions of the elevation of blood glucose and insulin concentration under the doses of 5 g or more D-psicose with dose dependency. An independent administration of 7.5 g D-psicose had no influence on blood glucose or insulin concentration. D-Psicose is considered efficacious in the suppression of the elevation of blood glucose concentration after eating in humans.
authors.affiliation: Research Institute, Matsutani Chemical Industry Co., Ltd., Kita-Itami, Itami, Japan. tetsuo-iida@matsutani.co.jp
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Iida
authors.forename: Yuka
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yoshikawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Hayashi
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Okuma
authors.forename: Mikiko
authors.initials: M
authors.lastname: Tohi
authors.forename: Kanako
authors.initials: K
authors.lastname: Yagi
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Matsuo
authors.forename: Ken
authors.initials: K
authors.lastname: Izumori
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000494:pharmacology*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007564:Japan; D008297:Male; D011134:Polysaccharides / Q000008:administration & dosage / Q000494:pharmacology*; D016037:Single-Blind Method; D013549:Sweetening Agents / Q000008:administration & dosage / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin; D011134:Polysaccharides; D013549:Sweetening Agents; C003243:psicose; D005632:Fructose; C008315:maltodextrin; D005947:Glucose