Regulation of plasma membrane calcium fluxes by mitochondria.
The role of mitochondria in cell signaling is becoming increasingly apparent, to an extent that the signaling role of mitochondria appears to have stolen the spotlight from their primary function as energy producers. In this chapter, we will review the ionic basis of calcium handling by mitochondria and discuss the mechanisms that these organelles use to regulate the activity of plasma membrane calcium channels and transporters.
Demaurex
Nicolas
N
Department of Cell Physiology and Metabolism, University of Geneva, 1, rue Michel-Servet, CH-1211 Geneva 4, Switzerland.
Poburko
Damon
D
Frieden
Maud
M
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology; D002462:Cell Membrane / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008928:Mitochondria / Q000502:physiology*; D019831:Sodium-Calcium Exchanger / Q000502:physiology; D050053:TRPM Cation Channels / Q000502:physiology
D015220:Calcium Channels; D019831:Sodium-Calcium Exchanger; D050053:TRPM Cation Channels; C121934:TRPM2 protein, human; C034703:mitochondrial calcium uniporter; D002118:Calcium