title: [Hyponatraemia as a clinical manifestation of hypopituitarism caused by neurosarcoidosis].
abstract: Severe hyponatraemia was observed in a 35-year-old man with progressive malaise; this was caused by hypopituitarism and secondary hypocortisolism as a result ofneurosarcoidosis. Sarcoidosis is a multisystem granulomatous disorder of unknown aetiology which can develop in any of the body's organs or tissues. The central nervous system is affected in only 5-15% of patients with sarcoidosis. Neurosarcoidosis is a rare disorder with clinical heterogeneity. Extensive diagnostic procedures, including MRI of the cerebrum and histological investigation, and structural outpatient follow-up are mandatory in patients in whom neurosarcoidosis is suspected. Treatment consists mainly of high-dose corticosteroids, which usually have to be taken long-term. Clinical course and prognosis are variable, and depend on the accompanying symptoms.
authors.affiliation: Afd. Interne Geneeskunde, Albert Schweitzer Ziekenhuis, locatie Dordwijk, Postbus 444, 3300 AK Dordrecht. php-de-jong@hotmail.com
authors.forename: P H P
authors.initials: PH
authors.lastname: de Jong
authors.forename: R J M
authors.initials: RJ
authors.lastname: van Leendert
authors.forename: M
authors.initials: M
authors.lastname: de Waal
authors.forename: E F H
authors.initials: EF
authors.lastname: van Bommel
mesh_terms: D000328:Adult; D006801:Humans; D007010:Hyponatremia / Q000175:diagnosis / Q000209:etiology*; D007018:Hypopituitarism / Q000209:etiology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009422:Nervous System Diseases / Q000503:physiopathology*; D010902:Pituitary Gland / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D012507:Sarcoidosis / Q000503:physiopathology*