title: Hemodynamic analysis of microcirculation in malaria infection.
abstract: Malaria-infected red blood cells (IRBCs) show various changes in mechanical properties. IRBCs lose their deformability and develop properties of cytoadherence and rosetting. To clarify how these changes advance microvascular occlusion, we need qualitative and quantitative information on hemodynamics in malaria infection, including the interaction among IRBCs, healthy RBCs, and endothelial cells. We developed a numerical model of blood flow with IRBCs based on conservation laws of fluid dynamics. The deformability and adhesive property of IRBCs were simply modeled using springs governed by Hook's law. Our model could express the basic behavior of IRBCs, including the rolling motion due to cytoadhesive interaction with endothelial cells and complex interaction with healthy RBCs. We confirmed that these types of interactions significantly increase the flow resistance, particularly when knobs develop.
authors.affiliation: Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki Aza Aoba, Sendai 980-8579, Japan.
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kondo
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Imai
authors.forename: Takuji
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Tsubota
authors.forename: Takami
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002448:Cell Adhesion; D042783:Endothelial Cells / Q000378:metabolism / Q000469:parasitology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000469:parasitology; D004912:Erythrocytes / Q000378:metabolism / Q000469:parasitology; D006439:Hemodynamics; D016778:Malaria, Falciparum / Q000097:blood*; D008833:Microcirculation; D008954:Models, Biological; D009038:Motion; D012212:Rheology; D052939:Schizonts / Q000469:parasitology; D053058:Trophozoites / Q000469:parasitology