title: Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation protocol for the synthesis of indenoisoquinolines.
abstract: Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries.
authors.affiliation: Department of Chemistry, University of Kansas, 1251 Wescoe Hall Drive, Lawrence, Kansas 66045, USA.
authors.forename: Thiruvellore Thatai
authors.initials: TT
authors.lastname: Jayanth
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Johnson
authors.forename: Helena C
authors.initials: HC
authors.lastname: Malinakova
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D006846:Hydrocarbons, Halogenated; D007097:Imines; D007192:Indenes; D007546:Isoquinolines; D017971:Tin Compounds; D014753:Vinyl Compounds; C031525:stannane; D010165:Palladium; D003300:Copper