Effects of grape seed extract and its ethylacetate/ethanol fraction on blood glucose levels in a model of type 2 diabetes.
The present study observed the effects of grape seed extract (GSE) and its ethylacetate (E) and ethylacetate/ethanol (EE) fractions on blood glucose levels in C57BL/KsJ-lepr(db)/lepr(db) (db/db) mice at 4-12 weeks of age. In the GSE- and EE fraction-treated db/db group, the blood glucose concentration began to be lower than that in the vehicle-treated db/db group at 6 weeks after treatment, while the blood glucose concentration in the E fraction-treated db/db group was similar to that in the vehicle-treated db/db group. The glycosylated hemoglobin (HbA1c) level in the vehicle-treated db/db groups was 9.3%, whereas HbA1c levels in the GSE- and EE fraction-treated db/db group decreased significantly to 5.7% and 6.1%, respectively, at 8 weeks after treatment. However, administration of GSE and its EE fraction did not show any significant effects on body weights and food consumption in db/db mice. These results suggest that GSE and its EE fraction have a potential to decrease the blood glucose and HbA1c level, which is applicable to good healthy foods for reducing blood glucose levels.
Hwang
In Koo
IK
Department of Anatomy and Cell Biology, College of Veterinary Medicine and BK21 Program for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
Kim
Dae Won
DW
Park
Jun Hong
JH
Lim
Soon Sung
SS
Yoo
Ki-Yeon
KY
Kwon
Dae Young
DY
Kim
Dong-Woo
DW
Moon
Won-Kook
WK
Won
Moo-Ho
MH
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D004435:Eating / Q000187:drug effects; D005260:Female; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012639:Seeds / Q000737:chemistry; D027843:Vitis / Q000737:chemistry*
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D010936:Plant Extracts