Common variants of hepatocyte nuclear factor 1beta are associated with type 2 diabetes in a Chinese population.
OBJECTIVE
Hepatocyte nuclear factor 1beta (HNF1beta) is a transcription factor that is critical for pancreatic cell formation and glucose homeostasis. Previous studies have reported that common variants of HNF1beta were associated with type 2 diabetes in Caucasians and West Africans. However, analysis in the subjects from the Botnia study and Malmö Preventive Project produced conflicting results, and the role for HNF1beta in type 2 diabetes susceptibility remains unclear. We therefore investigated common variants across the HNF1beta gene in a Chinese population.


METHODS
Fifteen tagging single nucleotide polymorphisms (SNPs) were analyzed for association with type 2 diabetes in subjects with type 2 diabetes (n = 1,859) and normal glucose regulation (n = 1,785).


RESULTS
Consistent with the initial study, we observed evidence that the risk G allele of rs4430796 in intron 2 was significantly associated with type 2 diabetes (odds ratio 1.16 [95% CI 1.05-1.29], P = 0.0035, empirical P = 0.0475). Furthermore, the at-risk G allele was associated with earlier age at diagnosis in the type 2 diabetic subjects (P = 0.0228).


CONCLUSIONS
The result of this study provides evidence that variants in the HNF1beta region contribute to susceptibility to type 2 diabetes in the Chinese population.
Wang
Congrong
C
Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China.
Hu
Cheng
C
Zhang
Rong
R
Bao
Yuqian
Y
Ma
Xiaojing
X
Lu
Jingyi
J
Qin
Wen
W
Shao
Xinyu
X
Lu
Junxi
J
Xu
Jing
J
Lu
Huijuan
H
Xiang
Kunsan
K
Jia
Weiping
W
D017668:Age of Onset; D000368:Aged; D044466:Asian People / Q000235:genetics*; D044383:Black People / Q000235:genetics; D001786:Blood Glucose; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D051539:Hepatocyte Nuclear Factor 1-beta / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
D001786:Blood Glucose; D051539:Hepatocyte Nuclear Factor 1-beta