title: Beneficial effect of insulin-like growth factor-1 on hypoxemic renal dysfunction in the newborn rabbit.
abstract: Acute normocapnic hypoxemia can cause functional renal insufficiency by increasing renal vascular resistance (RVR), leading to renal hypoperfusion and decreased glomerular filtration rate (GFR). Insulin-like growth factor 1 (IGF-1) activity is low in fetuses and newborns and further decreases during hypoxia. IGF-1 administration to humans and adult animals induces pre- and postglomerular vasodilation, thereby increasing GFR and renal blood flow (RBF). A potential protective effect of IGF-1 on renal function was evaluated in newborn rabbits with hypoxemia-induced renal insufficiency. Renal function and hemodynamic parameters were assessed in 17 anesthetized and mechanically ventilated newborn rabbits. After hypoxemia stabilization, saline solution (time control) or IGF-1 (1 mg/kg) was given as an intravenous (i.v.) bolus, and renal function was determined for six 30-min periods. Normocapnic hypoxemia significantly increased RVR (+16%), leading to decreased GFR (-14%), RBF (-19%) and diuresis (-12%), with an increased filtration fraction (FF). Saline solution resulted in a worsening of parameters affected by hypoxemia. Contrarily, although mean blood pressure decreased slightly but significantly, IGF-1 prevented a further increase in RVR, with subsequent improvement of GFR, RBF and diuresis. FF indicated relative postglomerular vasodilation. Although hypoxemia-induced acute renal failure was not completely prevented, IGF-1 elicited efferent vasodilation, thereby precluding a further decline in renal function.
authors.affiliation: Nephrology Unit, Department of Pediatrics, Lausanne University Medical Center (CHUV), Lausanne, Switzerland. prevotanne@hotmail.com
authors.forename: Anne
authors.initials: A
authors.lastname: Prévot
authors.forename: Monique
authors.initials: M
authors.lastname: Julita
authors.forename: David K
authors.initials: DK
authors.lastname: Tung
authors.forename: Dolores
authors.initials: D
authors.lastname: Mosig
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000150:complications* / Q000188:drug therapy; D007275:Injections, Intravenous; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage / Q000494:pharmacology*; D007674:Kidney Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D007677:Kidney Function Tests; D008136:Longevity / Q000187:drug effects; D011817:Rabbits; D012079:Renal Circulation / Q000187:drug effects; D015996:Survival Rate; D016482:Urinalysis; D014664:Vasodilation / Q000187:drug effects
chemical_list: D007334:Insulin-Like Growth Factor I