title: Cation exchange separation of 61Cu2+ from natCo targets and preparation of 61Cu-DOTA-HSA as a blood pool agent.
abstract: An improved method for isolation of (61)Cu(2+) from a (nat)Co target using cation exchange was developed. (61)Cu(2+) was eluted from a cation exchange resin column by 0.2 M HCl with 90% acetone, while Co(2+) remained on the column. The whole separation process was completed within 50 min at more than 72% yield. The Co(2+) impurity level in (61)Cu(2+) solution was reduced to less than 0.1 ppm. Highly pure (61)Cu(2+) solution was then applied to prepare (61)Cu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-human serum albumin (HSA) which showed good blood pool imaging properties.
authors.affiliation: Molecular Imaging Center, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, Japan.
authors.forename: Guiyang
authors.initials: G
authors.lastname: Hao
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Fukumura
authors.forename: Ryuji
authors.initials: R
authors.lastname: Nakao
authors.forename: Hisashi
authors.initials: H
authors.lastname: Suzuki
authors.forename: Ferenc
authors.initials: F
authors.lastname: Szelecsényi
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kovács
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D001345:Autoradiography; D002411:Cation Exchange Resins; D002851:Chromatography, High Pressure Liquid; D003035:Cobalt / Q000737:chemistry*; D003301:Copper Radioisotopes; D015637:Gated Blood-Pool Imaging; D009942:Organometallic Compounds / Q000737:chemistry; D012709:Serum Albumin / Q000737:chemistry; D014018:Tissue Distribution
chemical_list: C539909:61Cu-DOTA-HSA; D002411:Cation Exchange Resins; D003301:Copper Radioisotopes; D009942:Organometallic Compounds; D012709:Serum Albumin; D003035:Cobalt