title: Effect of Roux-en-Y gastric bypass surgery on the sex steroids and quality of life in obese men.
abstract: BACKGROUND
  The effect of bariatric surgery on the reproductive function of obese men is not entirely elucidated.
  
  
  OBJECTIVE
  The aim of the study was to define the effect of Roux-En-Y gastric bypass surgery on the reproductive hormones and sexual function in obese men.
  
  
  METHODS
  The cohort was followed for 2 yr at a clinical research center.
  
  
  METHODS
  Sixty-four severely obese men (22 who had gastric bypass surgery and 42 controls) participated in the study.
  
  
  METHODS
  Anthropometrics [weight, body mass index (BMI), and percentage body fat] and reproductive hormones were measured. The sexual quality of life was assessed using the Impact of Weight on the Quality Of Life-Lite questionnaire.
  
  
  METHODS
  Reproductive hormones and sexual quality of life were measured.
  
  
  RESULTS
  The mean age was 48.9 +/- 1.2 yr. At baseline, mean weight was 333.0 +/- 7.1 lb, BMI was 46.2 +/- 0.9 kg/m(2), and total testosterone was 339.9 +/- 21.32 ng/dl. BMI correlated positively with estradiol and negatively with total and free testosterone. Indices of dissatisfaction with sexual quality of life correlated positively with measures of obesity. Difficult sexual performance and low sexual desire correlated negatively with free and total testosterone (r = -0.273, P = 0.038; and r = -0.267, P = 0.042, respectively). After 2 yr, the gastric bypass surgery group had a significant decrease in BMI (-16.6 +/- 1.2 vs. -0.46 +/- 0.51 kg/m(2)) and estradiol (-8.1 +/- 2.4 vs. 1.6 +/- 1.4 pg/ml) and had an increase in total testosterone (310.8 +/- 47.6 vs. 14.2 +/- 15.3 ng/dl) and free testosterone (45.2 +/- 5.1 vs. -0.4 +/- 3.0 pg/ml). Sexual quality of life was improved after gastric bypass surgery.
  
  
  CONCLUSIONS
  Hormonal alterations and diminished sexual quality of life among obese men are related to degree of obesity, and both are improved after gastric bypass surgery.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, University of Utah, Salt Lake City, Utah 84132, USA. Ahmad.hammoud@hsc.utah.edu
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hammoud
authors.forename: Mark
authors.initials: M
authors.lastname: Gibson
authors.forename: Steven C
authors.initials: SC
authors.lastname: Hunt
authors.forename: Ted D
authors.initials: TD
authors.lastname: Adams
authors.forename: Douglass T
authors.initials: DT
authors.lastname: Carrell
authors.forename: Ronette L
authors.initials: RL
authors.lastname: Kolotkin
authors.forename: A Wayne
authors.initials: AW
authors.lastname: Meikle
mesh_terms: D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000523:psychology* / Q000706:statistics & numerical data*; D006801:Humans; D007989:Libido; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000097:blood / Q000503:physiopathology / Q000523:psychology / Q000601:surgery*; D010549:Personal Satisfaction; D012725:Sexual Behavior; D013739:Testosterone / Q000097:blood; D015431:Weight Loss
chemical_list: D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002097:C-Reactive Protein