Total synthesis of (+)-azinothricin and (+)-kettapeptin.
Asymmetric total syntheses of (+)-azinothricin and (+)-kettapeptin have been completed through a common new pathway that exploits a highly chemoselective coupling reaction between the fully elaborated cyclodepsipeptide 5 and the glycal activated esters 3 and 4 at the final stages of both respective syntheses.
Hale
Karl J
KJ
The School of Chemistry & Chemical Engineering, and the Centre for Cancer Research and Cell Biology, Queen's University Belfast (QUB), Stranmillis Road, Belfast BT9 5AG, UK.
Manaviazar
Soraya
S
George
Jonathan H
JH
Walters
Marcus A
MA
Dalby
Stephen M
SM
D047630:Depsipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D047630:Depsipeptides; D004952:Esters; D010455:Peptides; C512876:kettapeptin; C048098:azinothricin; C056791:A 83586C