title: Spatial signaling networks converge at the adaptor protein Shc.
abstract: Endothelial cells, which are located at the interface between the blood and the vessel wall, respond dynamically to a variety of stimuli initiating signaling cascades that regulate cardiovascular development, physiology and pathology. These inputs include soluble factors that bind to their receptors, integrin-matrix interactions, cell-cell contacts and mechanical forces due to the flowing blood. While these stimuli can mediate unique downstream signals, it is well-accepted that signaling pathways are highly interwoven into complex signaling networks with several levels of cross-talk, integration and coordination. Recent studies suggest that several signaling networks coalesce at the adaptor protein Shc.
authors.affiliation: Department of Cell and Molecular Physiology and Program in Genetics and Molecular Biology, Chapel Hill, North Carolina 27599, USA. etzima@med.unc.edu
authors.forename: Daniel Timothy
authors.initials: DT
authors.lastname: Sweet
authors.forename: Ellie
authors.initials: E
authors.lastname: Tzima
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D021982:Cell-Matrix Junctions / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D055765:Shc Signaling Adaptor Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D055765:Shc Signaling Adaptor Proteins; D011505:Protein-Tyrosine Kinases