Treatment of primary liver tumors with Yttrium-90 microspheres (TheraSphere) in high risk patients: analysis of survival and toxicities.
This retrospective study was undertaken to obtain information regarding the survival and toxicities after Yttrium-90 microspheres treatment in patients with primary liver malignancies. Baseline, treatment, and follow-up data were collected and analyzed for 21 patients treated with Yttrium-90 microspheres. Survival analysis was then performed. The results of this study showed that median survival for all the patients was 120 days. Twenty of 21 patients were categorized as high-risk with a median survival of 114 days. It was also found that one high-risk patient has survived 858 days with no recurrence of disease. Acute grade 3-5 toxicities were recorded for nine patients and consisted of elevations in AST and bilirubin, thrombocytopenia, abdominal pain, ascites, nausea, fatigue, and death. This study concluded that Yttrium-90 is a low-toxicity, outpatient alternative for individuals with liver cancer and without many options. The maximal value, however, may lie in the treatment of low-risk patients.
Reardon
Kelli A
KA
Department of Radiation Oncology, University of Virginia, Charlottesville, VA 22908-0383, USA.
McIntosh
Alyson F
AF
Shilling
A Tanner
AT
Hagspiel
Klaus D
KD
Al-Osaimi
Abdullah
A
Berg
Carl
C
Caldwell
Stephen H
SH
Northup
Patrick G
PG
Angle
Fritz
F
Mulder
Robert
R
Rich
Tyvin A
TA
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006760:Hospitalization; D006801:Humans; D008113:Liver Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D012189:Retrospective Studies; D015021:Yttrium Radioisotopes / Q000008:administration & dosage* / Q000009:adverse effects
D015021:Yttrium Radioisotopes