Development of carcinoid tumour in hormonally treated adenocarcinoma of the prostate.
We present the case of an 81-yr-old man with a prostatic adenocarcinoma and a metastatic carcinoid. Simultaneous occurrence of hormonally treated adenocarcinoma of the prostate and a carcinoid has been described before. The pathogenesis of this coincidence is largely unclear; however, androgen deprivation therapy might play a key role in neuroendocrine differentiation of adenocarcinoma cells. Early recognition of the carcinoid syndrome is crucial, as surgical cure is not possible after metastasis. We provide a brief review of recent literature.
Molenaar
Joery P F
JP
Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. joerymolenaar@student.ru.nl
Baten
Anique
A
Blokx
Willeke A M
WA
Hoogendam
Arjen
A
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000369:Aged, 80 and over; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000813:Anilides / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001706:Biopsy; D002276:Carcinoid Tumor / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008303:Malignant Carcinoid Syndrome / Q000188:drug therapy; D009378:Neoplasms, Multiple Primary; D009570:Nitriles / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013004:Somatostatin / Q000031:analogs & derivatives / Q000627:therapeutic use; D014105:Tosyl Compounds / Q000627:therapeutic use*
D000726:Androgen Antagonists; D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D009570:Nitriles; D014105:Tosyl Compounds; D013004:Somatostatin; C053541:bicalutamide