[When an enterovirus emerges].
Most of enterovirus infections are benign and the rate of mortality is low in countries with temperate climates. But since the late 1990s, Enterovirus 71 (EV-71) has become much more aggressive in Asian countries, with the outcome of a neurogenic pulmonary oedema syndrome and it is responsible for huge epidemics. The virological diagnosis rely upon viral isolation and identification by sero-neutralization, and upon the detection of specific IgM by ELISA and viral RNA by RT-PCR. There is no specific treatment to fight this virus, but innovative strategies, especially based on interfering RNA, are under investigation.
Kairis
B
B
Laboratoire de Virologie/UPRES EA3610, Faculté de Médecine, Centre de Biologie Pathologie, Université Lille-2, CHRU de Lille, Bâtiment P.- Boulanger, Boulevard du Pr-Jules-Leclercq, 59037 Lille, France.
Sauter
P
P
Goffard
A
A
Fronval
S
S
Sane
F
F
Hober
D
D
D001208:Asia / Q000453:epidemiology; D004770:Enterovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000453:epidemiology* / Q000401:mortality / Q000517:prevention & control; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D011654:Pulmonary Edema / Q000453:epidemiology / Q000821:virology; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction
D007075:Immunoglobulin M; D012367:RNA, Viral