title: How not to get scar(r)ed: pointers to the correct diagnosis in patients with suspected primary cicatricial alopecia.
abstract: Primary cicatricial alopecias (PCAs) are a rare, but important, group of disorders that cause irreversible damage to hair follicles resulting in scarring and permanent hair loss. They may also signify an underlying systemic disease. Thus, it is of paramount importance that clinicians who manage patients with hair loss are able to diagnose these disorders accurately. Unfortunately, PCAs are notoriously difficult conditions to diagnose and treat. The aim of this review is to present a rational and pragmatic guide to help clinicians in the professional assessment, investigation and diagnosis of patients with PCA. Illustrating typical clinical and histopathological presentations of key PCA entities we show how dermatoscopy can be profitably used for clinical diagnosis. Further, we advocate the search for loss of follicular ostia as a clinical hallmark of PCA, and suggest pragmatic strategies that allow rapid formulation of a working diagnosis.
authors.affiliation: Dermatological Sciences, The University of Manchester, Salford Royal Hospital, Manchester M6 8HD, UK. mjharries@doctors.org.uk
authors.forename: M J
authors.initials: MJ
authors.lastname: Harries
authors.forename: R M
authors.initials: RM
authors.lastname: Trueb
authors.forename: A
authors.initials: A
authors.lastname: Tosti
authors.forename: A G
authors.initials: AG
authors.lastname: Messenger
authors.forename: I
authors.initials: I
authors.lastname: Chaudhry
authors.forename: D A
authors.initials: DA
authors.lastname: Whiting
authors.forename: R
authors.initials: R
authors.lastname: Sinclair
authors.forename: C E M
authors.initials: CE
authors.lastname: Griffiths
authors.forename: R
authors.initials: R
authors.lastname: Paus
mesh_terms: D000465:Algorithms; D000505:Alopecia / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D001706:Biopsy; D002921:Cicatrix / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D003937:Diagnosis, Differential; D018859:Hair Follicle / Q000473:pathology; D006801:Humans