title: [Selective serotonin reuptake inhibitor is more likely to induce sexual dysfunction than mirtazapine in treating depression].
abstract: OBJECTIVE
  To compare the incidences of sexual dysfunction induced by mirtazapine and SSRI in the treatment of patients with depression.
  
  
  METHODS
  Using key-word retrieval from the compact disks of the Chinese biological medicine (CBM) data base, we analyzed the rates of sexual dysfunction from the published clinical control trials on depression treated with mirtazapine and SSRI by applying the fixed effects model (FEM) of evidence-based medicine (EBM).
  
  
  RESULTS
  Among 1108 cases in 14 studies, there were 5 cases of mirtazapine-induced and 106 cases of SSRI-induced sexual dysfunction, accounting for 0.90% and 19.2% respectively, OR = 0.07 (95% CI: 0.04-0.14), Z = 8.03, P < 0.01.
  
  
  CONCLUSIONS
  SSRI is far more likely to induce sexual dysfunction than mirtazapine in the treatment of depression.
authors.affiliation: Department of Psychiatry, Zhejiang Province Mental Health Center, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang 310012, China.
authors.forename: Zheng-xin
authors.initials: ZX
authors.lastname: Chen
authors.forename: He-qiu
authors.initials: HQ
authors.lastname: Wang
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Jin
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy; D007172:Erectile Dysfunction / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives*; D000078785:Mirtazapine; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D008803:Mianserin; D000078785:Mirtazapine; D017367:Selective Serotonin Reuptake Inhibitors