Autophagy SEPArates germline and somatic cells.
Cellular determinants of the germline selectively accumulate in germ cell precursors and influence cell fate during early development in many organisms. Zhang et al. (2009) now report that targeted autophagy mediated by the SEPA-1 protein depletes germplasm proteins from somatic cells during early development of the nematode.
Baehrecke
Eric H
EH
Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. eric.baehrecke@umassmed.edu
D000818:Animals; D001343:Autophagy; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000196:embryology* / Q000378:metabolism; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D003594:Cytoplasmic Granules / Q000378:metabolism; D005854:Germ Cells / Q000378:metabolism
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; C534958:SEPA-1 protein, C elegans