title: Transapical transcatheter aortic valve implantation: 1-year outcome in 26 patients.
abstract: BACKGROUND
  We reported the first case of successful transapical transcatheter aortic valve implantation in a human subject in 2005 and have now completed a 12-month follow-up on our first 26 patients. This is, to date, the longest follow-up of patients undergoing transapical aortic valve implantation.
  
  
  METHODS
  Between October 2005 and January 2007, 26 patients (13 female) underwent transcatheter transapical aortic valve implantation with either 23- or 26-mm Edwards Lifesciences transcatheter bioprostheses. All patients with symptomatic aortic stenosis were declined for conventional aortic valve replacement because of unacceptable operative risks and were not candidates for transfemoral aortic valve implantation because of poor arterial access. Clinical and echocardiographic follow-up was performed before discharge and at 1, 6, and 12 months. Data from the 17 patients who survived over 12 months were used for comparisons of the baseline and follow-up results.
  
  
  RESULTS
  The mean age was 80 +/- 9 years, and the predicted operative mortality was 37% +/- 20% by using logistic EuroSCORE and 11% +/- 6% by using the Society of Thoracic Surgeons Risk Calculator. Valves were successfully implanted in all patients. Six patients died within 30 days (30-day mortality, 23%), and 3 patients died from noncardiovascular causes after 30 days (late mortality, 12%). Among patients who survived at least 30 days, 12-month survival was 85%. There were no late valve-related complications. New York Heart Association functional class improved significantly. The aortic valve area and mean gradient remained stable at 12 months (1.6 +/- 0.3 cm(2) and 9.6 +/- 4.8 mm Hg, respectively).
  
  
  CONCLUSIONS
  Our 1-year clinical and echocardiographic outcomes suggest that transapical transcatheter aortic valve implantation is a viable alternative to conventional aortic valve replacement in selected high-risk patients.
authors.affiliation: Division of Cardiac Surgery, St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. jye@providencehealth.bc.ca
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.forename: Anson
authors.initials: A
authors.lastname: Cheung
authors.forename: Samuel V
authors.initials: SV
authors.lastname: Lichtenstein
authors.forename: Lukas A
authors.initials: LA
authors.lastname: Altwegg
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Wong
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Carere
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Thompson
authors.forename: Robert R
authors.initials: RR
authors.lastname: Moss
authors.forename: Brad
authors.initials: B
authors.lastname: Munt
authors.forename: Sanjeevan
authors.initials: S
authors.lastname: Pasupati
authors.forename: Robert H
authors.initials: RH
authors.lastname: Boone
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Masson
authors.forename: Abdullah
authors.initials: A
authors.lastname: Al Ali
authors.forename: John G
authors.initials: JG
authors.lastname: Webb
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D006328:Cardiac Catheterization; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography