title: Atypical carcinoid of the larynx and potential complications of the carcinoid syndrome: a case report.
abstract: A 47-year-old man with a history of allergic rhinitis presented with a several-month history of nasal symptoms and gastroesophageal reflux disease. He also had clinical depression, for which he had been taking a selective serotonin reuptake inhibitor (SSRI). During evaluation, flexible laryngoscopy incidentally detected a left interarytenoid polyp. Biopsy identified the lesion as a moderately differentiated neuroendocrine carcinoma. In addition to conducting a metastatic workup, we determined that it was necessary to evaluate the functional status of the tumor prior to excision because the SSRI could precipitate a carcinoid syndrome. We discuss the characteristics and management of different neuroendocrine carcinomas of the larynx, and we review the potential complications of the carcinoid syndrome.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, JHOC 6210, 601 N. Caroline St., Baltimore, MD 21287-0910, USA. meena.seshamani@gmail.com
authors.forename: Meena
authors.initials: M
authors.lastname: Seshamani
authors.forename: Eugene
authors.initials: E
authors.lastname: Einhorn
authors.forename: Natasha
authors.initials: N
authors.lastname: Mirza
mesh_terms: D001707:Biopsy, Needle; D002276:Carcinoid Tumor / Q000150:complications / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D007828:Laryngoscopy / Q000379:methods*; D008297:Male; D008303:Malignant Carcinoid Syndrome / Q000209:etiology* / Q000517:prevention & control; D008875:Middle Aged; D009367:Neoplasm Staging; D018570:Risk Assessment; D016896:Treatment Outcome