title: Catalytic asymmetric synthesis of 2,2-disubstituted oxetanes from ketones by using a one-pot sequential addition of sulfur ylide.
abstract: Better the second time around: The title compounds were synthesized by using a one-pot double methylene transfer catalyzed by a heterobimetallic La/Li complex. Chiral amplification in the second step was the key to obtaining oxetanes in high enantiomeric excess (see scheme).
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Sone
authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki
mesh_terms: D002384:Catalysis; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008674:Metals, Rare Earth / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D013237:Stereoisomerism; D013455:Sulfur / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D007659:Ketones; D008674:Metals, Rare Earth; D009943:Organophosphorus Compounds; D013455:Sulfur; C005287:oxetane