title: Antibacterial alkaloids from chelidonium majus linn (papaveraceae) against clinical isolates of methicillin-resistant Staphylococcus aureus.
abstract: OBJECTIVE
  This study describes the antibacterial effect of extracts and compounds isolated from the aerial part of Chelidonium majus Linn. (Papaveraceae) acting against clinical strains of methicillin-resistant Staphylococcus aureus (MRSA).
  
  
  METHODS
  The activities were evaluated by using the macrobroth dilution method and reported as the MICs/MBCs.
  
  
  RESULTS
  Bioassay-guided fractionation of the most active extract from the aerial parts (EtOAc) led to the isolation of benzo[c]phenanthridine-type alkaloids 8-hydroxydihydrosanguinarine (hhS), 8-hydroxydihydrochelerythrine (hhC), which were potently active against MRSA strains.
  
  
  CONCLUSIONS
  The selective antibacterial activity reported in this paper for 8-hydroxylated benzo[c]phenanthridine-type alkaloids isolated from C.majus opens the possibility that they could be helpful for the developing of new antibacterial agents for treating the infection of MRSA which has created nosocomial problem worldwide.
authors.affiliation: Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming, China. zuoguoying@263.net
authors.forename: Guo Ying
authors.initials: GY
authors.lastname: Zuo
authors.forename: Fan Yan
authors.initials: FY
authors.lastname: Meng
authors.forename: Xiao Yan
authors.initials: XY
authors.lastname: Hao
authors.forename: Yun Ling
authors.initials: YL
authors.lastname: Zhang
authors.forename: Gen Chun
authors.initials: GC
authors.lastname: Wang
authors.forename: Gui Li
authors.initials: GL
authors.lastname: Xu
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D028101:Papaveraceae / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D010936:Plant Extracts