Immune response of E. cuniculi infected mice to aflatoxin B1.
The immunomodulatory effects of aflatoxin B1 (AFB1) on mice experimentally infected with Encephalitozoon cuniculi (E. cuniculi) were studied. Mice inoculated intraperitoneally with spores of E. cuniculi drank a daily solution of AFB1 (0.2 mg kg(-1) of body weight) for 27 days. Application of AFB1 to mice demonstrated a decrease of immunocompetent cells. On the other hand, the mice infected with E. cuniculi and given AFB1 showed significant increased number of both monocytes and CD8+ T cells, and tendency to a decrease in CD4+ T cells. Aflatoxin B1 revealed to merely modulate systemic immune response of E. cuniculi infected mice.
Levkutová
M
M
University of Veterinary Medicine, Kosice, Slovak Republic.
Levkut
M
M
Hipíková
V
V
Tomková
I
I
Conková
E
E
Laciaková
A
A
D000284:Administration, Oral; D016604:Aflatoxin B1 / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D009670:Encephalitozoon cuniculi / Q000472:pathogenicity*; D016890:Encephalitozoonosis / Q000276:immunology* / Q000382:microbiology; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D013997:Time Factors
D007155:Immunologic Factors; D016604:Aflatoxin B1