title: Immune response of E. cuniculi infected mice to aflatoxin B1.
abstract: The immunomodulatory effects of aflatoxin B1 (AFB1) on mice experimentally infected with Encephalitozoon cuniculi (E. cuniculi) were studied. Mice inoculated intraperitoneally with spores of E. cuniculi drank a daily solution of AFB1 (0.2 mg kg(-1) of body weight) for 27 days. Application of AFB1 to mice demonstrated a decrease of immunocompetent cells. On the other hand, the mice infected with E. cuniculi and given AFB1 showed significant increased number of both monocytes and CD8+ T cells, and tendency to a decrease in CD4+ T cells. Aflatoxin B1 revealed to merely modulate systemic immune response of E. cuniculi infected mice.
authors.affiliation: University of Veterinary Medicine, Kosice, Slovak Republic.
authors.forename: M
authors.initials: M
authors.lastname: Levkutová
authors.forename: M
authors.initials: M
authors.lastname: Levkut
authors.forename: V
authors.initials: V
authors.lastname: Hipíková
authors.forename: I
authors.initials: I
authors.lastname: Tomková
authors.forename: E
authors.initials: E
authors.lastname: Conková
authors.forename: A
authors.initials: A
authors.lastname: Laciaková
mesh_terms: D000284:Administration, Oral; D016604:Aflatoxin B1 / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D009670:Encephalitozoon cuniculi / Q000472:pathogenicity*; D016890:Encephalitozoonosis / Q000276:immunology* / Q000382:microbiology; D005260:Female; D007155:Immunologic Factors / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology / Q000382:microbiology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D013997:Time Factors
chemical_list: D007155:Immunologic Factors; D016604:Aflatoxin B1