title: Complications due to transfusion-related acute lung injury.
abstract: BACKGROUND
  Transfusion-related acute lung injury is an underdiagnosed and potentially lethal complication of blood transfusion.
  
  
  METHODS
  A patient underwent surgery because of an ectopic pregnancy. During surgery, blood products were administered and within minutes she developed pulmonary edema and hypotension. Treatment included mechanical ventilation, intravenous fluids, antihistamines, inotropic agents, cortisol, and diuretics. It took 4 days for the pulmonary edema to resolve and the patient to recover. Analysis of the donor plasma revealed human leukocyte antigen antibodies against an antigen of the patient.
  
  
  CONCLUSIONS
  Although transfusion-related acute lung injury is usually self-limiting and most patients will recover spontaneously, the estimated mortality rate of 5-25% warrants prompt identification and adequate action.
authors.affiliation: From the Department of Gynecology, Bronovo Hospital, The Hague, The Netherlands; the Department of Internal Medicine, LUMC, Hospital, Leiden, The Netherlands; and the Department of Intensive Care, Reinier de Graaf Hospital, Delft, the Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Droog
authors.forename: S W
authors.initials: SW
authors.lastname: van Thiel
authors.forename: S J Sleeswijk
authors.initials: SJS
authors.lastname: Visser
authors.forename: J P T
authors.initials: JPT
authors.lastname: Rhemrev
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology*; D000328:Adult; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006465:Hemoperitoneum / Q000601:surgery / Q000628:therapy*; D006801:Humans; D007518:Isoantibodies / Q000009:adverse effects / Q000276:immunology; D010535:Laparoscopy; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000601:surgery*; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies