Coenzyme Q10 supplementation during pregnancy reduces the risk of pre-eclampsia.
OBJECTIVE
To assess whether supplementation with Coenzyme Q10 (CoQ10) during pregnancy reduces the risk of pre-eclampsia.


METHODS
Women at increased risk of pre-eclampsia were enrolled in a randomized, double-blind, placebo-controlled trial. Women were assigned to receive 200 mg of CoQ10 or placebo daily from 20 weeks of pregnancy until delivery. The primary outcome was rate of pre-eclampsia. Statistical analyses were by intention-to-treat.


RESULTS
Of the 235 women enrolled in the trial, 118 were randomized to receive CoQ10 and 117 received a placebo. A total of 197 (83.8%) women were followed-up. The overall rate of pre-eclampsia was 20% (n=47). Thirty women (25.6%) in the placebo group developed pre-eclampsia compared with 17 women (14.4%) in the CoQ10 group, and this reduction was significant (P=0.035) (relative risk [RR] 0.56; 95% confidence interval [CI], 0.33-0.96).


CONCLUSIONS
Supplementation with CoQ10 reduces the risk of developing pre-eclampsia in women at risk for the condition.
Teran
Enrique
E
Experimental Pharmacology and Cellular Metabolism Unit, Biomedical Center, Central University of Ecuador, Quito, Ecuador. eteran@cbm.uce.edu.ec
Hernandez
Isabel
I
Nieto
Belen
B
Tavara
Rosio
R
Ocampo
Juan Emilio
JE
Calle
Andres
A
D000293:Adolescent; D003627:Data Interpretation, Statistical; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D011225:Pre-Eclampsia / Q000517:prevention & control*; D011247:Pregnancy; D012307:Risk Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*; D055815:Young Adult
D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10