title: Sarcoidosis presenting with severe hypocalcaemia.
abstract: Disorders of calcium metabolism, especially hypercalcemia and hypercalceuria, are common in sarcoidosis. They are caused by extra renal unsuppressed production of 1,25 dihydroxy vitamin D at the level of the sarcoid granuloma. Hormonal changes during pregnancy have a physiological synergistic effect on this mechanism, which is primarily parathyroid hormone (PTH) dependant. However, the combination of primary hypoparathyroidism with hypocalcemia and sarcoidosis is rare. Di George syndrome, is a dysmorphic disorder characterised by aplasia/hypoplasia of thymus and parathyroid glands in addition to aortic arch anamolies and facial dysmorphia. After commencing appropriate treatment this lady made excellent recovary.
authors.affiliation: Department of Rheumatology, Mid Western Regional Hospital, Dooradoyle, Limerick, Ireland. modelian@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Saeed
authors.forename: M
authors.initials: M
authors.lastname: Khan
authors.forename: S
authors.initials: S
authors.lastname: Irwin
authors.forename: A
authors.initials: A
authors.lastname: Fraser
mesh_terms: D000328:Adult; D002118:Calcium / Q000627:therapeutic use; D004062:DiGeorge Syndrome / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D005260:Female; D006801:Humans; D006996:Hypocalcemia / Q000188:drug therapy / Q000209:etiology; D008206:Lymphatic Diseases / Q000150:complications*; D049590:Postpartum Period; D012507:Sarcoidosis / Q000150:complications* / Q000188:drug therapy; D013256:Steroids / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D013256:Steroids; D014807:Vitamin D; D002118:Calcium