Candidaemia: incidence, risk factors, characteristics and outcomes in immunocompetent critically ill patients.
A matched case-control study was conducted to determine the risk factors for development of candidaemia in patients requiring intensive-care unit (ICU) treatment for more than 48 h. Patients were matched according to length of ICU stay, age, department of admission, year of admission and sex. Forty-five patients with candidaemia were identified (0.6 cases/1000 patient-days). Candidaemia developed mainly in critically ill patients with multiple organ failure and end-stage disease. Candida colonization and gastrointestinal surgery were independently associated with candidaemia. ICU and total in-hospital mortality were 40% and 66.7%, respectively. Candidaemia-related mortality was 20%. Candidaemia treatment failure was the only variable associated with in-hospital mortality (p 0.008).
Vardakas
K Z
KZ
Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
Michalopoulos
A
A
Kiriakidou
K G
KG
Siampli
E P
EP
Samonis
G
G
Falagas
M E
ME
D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000188:drug therapy* / Q000453:epidemiology* / Q000401:mortality; D016022:Case-Control Studies; D016638:Critical Illness; D005260:Female; D016469:Fungemia / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D006801:Humans; D015994:Incidence; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016896:Treatment Outcome