Feasibility and accuracy of second-look laparoscopy after gastrectomy for gastric cancer.
BACKGROUND
A better method for detecting early peritoneal progression is needed. This study evaluated the feasibility and accuracy of second-look laparoscopy for patients with gastric cancer treated using systemic chemotherapy after gastrectomy.


METHODS
Second-look laparoscopy was conducted for patients who had no clinical evidence of distant metastases but had peritoneal metastases or positive peritoneal cytology results without visible metastatic disease at initial surgery, patients who underwent systemic chemotherapy over a 6-month period after surgery, and patients who had no clinical evidence of disease based on imaging study after completion of primary chemotherapy.


RESULTS
Between November 2004 and April 2008, 21 patients underwent second-look laparoscopy. At the initial surgery, 13 of these patients underwent total gastrectomy and 8 patients underwent distal gastrectomy. One or two sheets of adhesion barrier were received by 18 patients. The median interval between initial surgery and second-look laparoscopy was 9.8 months (range, 6.6-17.5 months). All second-look procedures were completed laparoscopically, and no patients required conversion to laparotomy. None of the 21 patients experienced postlaparoscopy complications. Whereas 12 patients showed no pathologic evidence of disease, 9 patients showed disease at second-look laparoscopy. There was a significant difference in median survival between the groups with negative and positive results (p = 0.017). The median survival for the negative group has not been determined. All the patients in the positive group received further chemotherapy while showing a good performance status (PS). Six patients were PS 0, and 3 patients were PS 1. The median survival time for this group was 10.1 months.


CONCLUSIONS
Second-look laparoscopy was a safe and promising approach to reassessment of peritoneal disease for patients with gastric cancer. The incidence of complications was low, particularly in this group of patients, all of whom had undergone prior gastrectomy.
Inoue
Kentaro
K
Department of Surgery, Kansai Medical University, 2-3-1 Sinmachi, Hirakata, Osaka, 573-1191, Japan. inoueke@hirakata.kmu.ac.jp
Nakane
Yasushi
Y
Michiura
Taku
T
Yamaki
Sou
S
Yui
Rintaro
R
Sakuramoto
Kazuhito
K
Iwai
Aiko
A
Tokuhara
Katsuji
K
Araki
Yoshiro
Y
Kim
Songtae
S
Nakai
Koji
K
Sato
Mutsuya
M
Yamamichi
Keigo
K
Kwon
A-Hon
AH
D000328:Adult; D000368:Aged; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000601:surgery*; D024162:Second-Look Surgery; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate