Renal transplant in HIV-positive patients: long-term outcomes and risk factors for graft loss.
In the highly active antiretroviral therapy era of improved survival for patients living with human immunodeficiency virus (HIV), chronic kidney disease now accounts for more than 10% of HIV-related deaths. The role of kidney transplant among HIV-positive patients with end-stage renal disease is under consideration, but concerns remain regarding allocation of kidneys to these patients when long-term benefit has not been firmly established. We evaluated 39,501 patients undergoing a renal transplant between January 1, 2004, and June 30, 2006, identified through the United Network for Organ Sharing national registry and found that, although long-term allograft survival is lower among HIV-positive recipients, controllable risk factors may explain this disparity. With proper donor selection and transplant recipient management, including the avoidance of prolonged cold ischemic time, use of living donors, and determination of optimal immunosuppression dosing before transplant, long-term graft survival comparable to that in HIV-negative patients can be achieved.
Locke
Jayme E
JE
Division of Transplantation, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA.
Montgomery
Robert A
RA
Warren
Daniel S
DS
Subramanian
Aruna
A
Segev
Dorry L
DL
D006679:HIV Seropositivity; D006801:Humans; D016030:Kidney Transplantation; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors; D017211:Treatment Failure