A case of pulmonary cryptococcosis followed by pleuritis in an apparently immunocompetent patient during fluconazole treatment.
Cryptococcal pleuritis is rare in individuals with no underlying disease. We report a case of pulmonary cryptococcosis followed by pleuritis in a patient on fluconazole treatment. Biopsy of the pleura revealed a granuloma and a cryptococcal body, while PCR and sequence analysis of extracted DNA from the pleura proved the presence of Cryptococcus species, most likely C. neoformans. Voriconazole with flucytosine and drainage of the pleural effusion were effective in treating the patient.
Izumikawa
Koichi
K
Second Department of Internal Medicine, Nagasaki University School of Medicine, Nagasaki, Japan. koizumik@nagasaki-u.ac.jp
Zhao
Yong
Y
Motoshima
Kohei
K
Takazono
Takahiro
T
Saijo
Tomomi
T
Kurihara
Sintaro
S
Nakamura
Shigeki
S
Miyazaki
Taiga
T
Seki
Masafumi
M
Kakeya
Hiroshi
H
Yamamoto
Yoshihiro
Y
Yanagihara
Katsunori
K
Miyazaki
Yoshitsugu
Y
Hayashi
Tomayoshi
T
Kohno
Shigeru
S
D000328:Adult; D001483:Base Sequence; D003453:Cryptococcosis / Q000188:drug therapy / Q000382:microbiology*; D003455:Cryptococcus neoformans / Q000235:genetics / Q000302:isolation & purification*; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects*; D008172:Lung Diseases, Fungal / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008969:Molecular Sequence Data; D010998:Pleurisy / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D016415:Sequence Alignment
D015725:Fluconazole