Investigation of T cell receptors in the peripheral blood of patients with active pulmonary tuberculosis.
T cells have the capability of recognizing target cells through their T cell receptors (TCRs). Thus, the percentages of CD3+/gamma-delta (gammadelta) TCR+ and CD3+/alpha-beta (alphabeta) TCR+ T lymphocytes were investigated in active and inactive pulmonary tuberculosis (PT) patients and in healthy individuals. CD3+ and CD3+/alphabeta TCR+ cell percentages were significantly lower in all PT patients than in healthy subjects. Percentages of CD3+/gammadelta and CD3+/alphabeta TCR+ were not statistically different between active and inactive PT patients. It was concluded that alphabeta TCR+ T cells might have a protective role in tuberculosis infection.
Akbulut
H H
HH
Department of Immunology, Faculty of Medicine, Firat University, Elazig 23119, Turkey. handanakbulut@yahoo.com
Deveci
F
F
Celik
I
I
Ilhan
F
F
Turgut
T
T
D000328:Adult; D001769:Blood / Q000276:immunology* / Q000382:microbiology*; D017252:CD3 Complex / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D055815:Young Adult
D017252:CD3 Complex; D011948:Receptors, Antigen, T-Cell