Persistent delirium predicts greater mortality.
OBJECTIVE
To examine the association between persistent delirium and 1-year mortality in newly admitted postacute care (PAC) facility patients with delirium who were followed regardless of residence.


METHODS
Observational cohort study.


METHODS
Eight greater-Boston skilled nursing facilities specializing in PAC.


METHODS
Four hundred twelve PAC patients with delirium at admission after an acute hospitalization.


METHODS
Assessments were done at baseline and four follow-up times: 2, 4, 12, and 26 weeks. Delirium, defined using the Confusion Assessment Method, was assessed, as were factors used as covariates in analyses: age, sex, comorbidity, functional status, and dementia. The outcome was 1-year mortality determined according to the National Death Index and corroborated using medical record and proxy telephone interview.


RESULTS
Nearly one-third of subjects remained delirious at 6 months. Cumulative 1-year mortality was 39%. Independent of age, sex, comorbidity, functional status, and dementia, subjects with persistent delirium were 2.9 (95% confidence interval 51.9-4.4) times as likely to die during the 1-year follow-up as subjects whose delirium resolved. This association remained strong and significant in groups with and without dementia. Additionally, when delirium resolved, the risk of death diminished thereafter.


CONCLUSIONS
In patients who were delirious at the time of PAC admission, persistent delirium was a significant independent predictor of 1-year mortality.
Kiely
Dan K
DK
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131-1097, USA. kiely@hrca.harvard.edu
Marcantonio
Edward R
ER
Inouye
Sharon K
SK
Shaffer
Michele L
ML
Bergmann
Margaret A
MA
Yang
Frances M
FM
Fearing
Michael A
MA
Jones
Richard N
RN
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003693:Delirium / Q000209:etiology / Q000401:mortality*; D005260:Female; D006707:Homes for the Aged; D006760:Hospitalization; D006801:Humans; D008297:Male; D009735:Nursing Homes