Interpretation of the Humphrey Matrix 24-2 test in the diagnosis of preperimetric glaucoma.
OBJECTIVE
To define the diagnostic precision of the Humphrey Matrix 24-2 test and to determine a clinically applicable cutoff criterion for the inclusion of preperimetric glaucoma.


METHODS
Eyes with preperimetric glaucoma (99 eyes) were defined as having normal standard automated perimetry (SAP) results and a glaucomatous optic nerve head, along with one or more optical coherence tomography (OCT) parameters flagged as <0.05 or a retinal nerve fiber layer (RNFL) defect on red-free fundus photographs. Normal controls (122 eyes) were defined as having a normal optic disc and RNFL with normal SAP. Receiver-operating characteristic (ROC) curves were constructed to determine the best-discriminating parameter of the frequency-doubling technology (FDT) Matrix. The sensitivity, specificity, and hit ratio of all available criteria were calculated from the FDT Matrix.


RESULTS
Pattern standard deviation (PSD) showed a larger area under the ROC curve (AUC) (0.767) than mean deviation (MD) (0.619). A pattern deviation plot (PDP) analysis by modified Anderson criteria showed the highest discriminating power, with a sensitivity of 75.76%, followed by a PSD cutoff value of 3.14 dB (sensitivity, 73.74%).


CONCLUSIONS
FDT Matrix seems to be a valuable clinical tool in the detection of preperimetric glaucoma. Among the parameters of the FDT Matrix, PDP analysis by modified Anderson criteria may provide a reliable cutoff criterion.
Choi
Jin A
JA
Department of Ophthalmology and Visual Sciences, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Lee
Na Young
NY
Department of Ophthalmology and Visual Sciences, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Park
Chan Kee
CK
Department of Ophthalmology and Visual Sciences, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. ckpark@catholic.ac.kr.|Department of Ophthalmology and Visual Science, Kangnam St. Mary's Hospital, College of Medicine, The Catholic University of Korea, #505 Banpo-dong, Seocho-gu, Seoul, 137-701, Korea. ckpark@catholic.ac.kr.
D001369:Axons / Q000473:pathology; D003627:Data Interpretation, Statistical; D005189:False Positive Reactions; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence; D014786:Vision Disorders / Q000175:diagnosis*; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields