title: The 'buoy' stent: evaluation of a prototype indwelling ureteric stent in a porcine model.
abstract: OBJECTIVE To assess a prototype ureteric 'buoy' stent with a 10 F upper body tapering to a 3F tail, developed to potentially reduce stent-related irritative symptoms while providing an adequate mould for healing after endopyelotomy. MATERIALS AND METHODS Eighteen Yucatan minipigs had the stent placed either into the intact ureter (phase I) or after Acucise proximal endoureterotomy (phase II). Buoy stents were compared to 10/7 F endopyelotomy stents and to standard 7 F stents in phases I and II, respectively. The pigs were assessed for vesico-ureteric reflux, hydronephrosis and infection, before stent insertion and at harvest. Stents were weighed before and after placement and the removal force was measured. Pressure/flow studies, antegrade nephrostograms and specimens for histopathology from the renal pelvis, ureter and vesico-ureteric junction (VUJ) were obtained at harvest. RESULTS Thirteen minipigs survived the entire study. Ureteric flow with the stents in situ was better for buoy stents than for 10/7 F stents (P < 0.005). Ureteric flow after endoureterotomy and subsequent stent removal was similar for buoy stents and standard 7 F stents. None of the stents refluxed. There was no difference between stents in removal force, weight change or incidence of hydronephrosis. At 1 and 12 weeks, buoy stents tended to produce lower histopathological alteration scores than control stents, especially at the VUJ (phase I, 2.0 vs 3.9, P = 0.092; phase II, 0.6 vs 1.7, P = 0.18). CONCLUSIONS The novel buoy stents are easily placed and removed via the urethra. They can cause less VUJ inflammation than standard stents while allowing for adequate ureteric flow and healing after proximal endoureterotomy.
authors.affiliation: Department of Urology, University of California, Irvine Medical Center, Orange, CA, USA.
authors.forename: Alfred
authors.initials: A
authors.lastname: Krebs
authors.forename: Leslie A
authors.initials: LA
authors.lastname: Deane
authors.forename: James F
authors.initials: JF
authors.lastname: Borin
authors.forename: Robert A
authors.initials: RA
authors.lastname: Edwards
authors.forename: Leandro G
authors.initials: LG
authors.lastname: Sala
authors.forename: Farhan
authors.initials: F
authors.lastname: Khan
authors.forename: Corollos
authors.initials: C
authors.lastname: Abdelshehid
authors.forename: Elspeth M
authors.initials: EM
authors.lastname: McDougall
authors.forename: Ralph V
authors.initials: RV
authors.lastname: Clayman
mesh_terms: D000818:Animals; D020878:Device Removal; D004867:Equipment Design; D005260:Female; D006869:Hydronephrosis / Q000517:prevention & control*; D015607:Stents / Q000382:microbiology / Q000592:standards*; D013552:Swine; D013556:Swine, Miniature; D014513:Ureter / Q000382:microbiology / Q000473:pathology / Q000601:surgery*; D014552:Urinary Tract Infections / Q000517:prevention & control*; D014718:Vesico-Ureteral Reflux / Q000517:prevention & control*