title: Evaluation of a compact tinnitus therapy by electrophysiological tinnitus decompensation measures.
abstract: Large-scale neural correlates of the tinnitus decompensation have been identified by using wavelet phase stability criteria of single sweep sequences of auditory late responses (ALRs). Our previous work showed that the synchronization stability in ALR sequences might be used for objective quantification of the tinnitus decompensation and attention which link to Jastreboff tinnitus model. In this study, we intend to provide an objective evaluation for quantifying the effect of music therapy in tinnitus patients. We examined neural correlates of the attentional mechanism in single sweep sequences of ALRs in chronic tinnitus patients who underwent compact therapy course by using the maximum entropy auditory paradigm. Results by our measure showed that the extent of differentiation between attended and unattended conditions improved significantly after the therapy. It is concluded that the wavelet phase synchronization stability of ALRs single sweeps can be used for the objective evaluation of tinnitus therapies, in this case the compact tinnitus music therapy.
authors.affiliation: Computational Diagnostics and Biocybernetics Unit at Saarland University Hospital and Saarland University of Applied Sciences, Homburg/Saarbruecken, Germany. yinfen@cdb-unit.de
authors.forename: Yin Fen
authors.initials: YF
authors.lastname: Low
authors.forename: Heike
authors.initials: H
authors.lastname: Argstatter
authors.forename: Hans Volker
authors.initials: HV
authors.lastname: Bolay
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Strauss
mesh_terms: D001931:Brain Mapping / Q000379:methods*; D003887:Desensitization, Psychologic / Q000379:methods*; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009147:Music Therapy / Q000379:methods*; D014012:Tinnitus / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome