[Simultaneous determination of residual veterinary drugs in livestock products and fish by liquid chromatography with tandem mass spectrometry].
A rapid multiresidue method was developed for determination of 98 veterinary drugs in livestock products and fish by LC/MS/MS. The drugs were extracted with methanol, and the extracted solution was diluted with water. The methanol concentration was adjusted to 50%, and finally the diluted solution was filtered through a microfiltration membrane (0.02 microm diameter pore size) prior to LC/MS/MS. Recoveries of 87 drugs from 4 foods (milk, egg, rainbow trout and cattle muscle) fortified at 0.2 microg/g were in the range of 50-150% with a coefficient of variation (%) of less than 20%. The values obtained by this method from livestock products containing antibiotics were similar to those obtained by the official methods. This proposed method is expected to be useful as a multiresidue analysis method for screening of veterinary drugs in livestock products and fish.
Kajita
Hiroko
H
Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Morioka-shi, Iwate 0200852, Japan.
Hatakeyama
Eriko
E
D000818:Animals; D002853:Chromatography, Liquid; D004350:Drug Residues / Q000032:analysis*; D004531:Eggs / Q000032:analysis*; D005399:Fishes / Q000378:metabolism*; D008892:Milk / Q000737:chemistry*; D053719:Tandem Mass Spectrometry; D019155:Veterinary Drugs / Q000032:analysis*
D019155:Veterinary Drugs