title: Hepatic composite tumor in a patient with primary sclerosing cholangitis.
abstract: A focal intrahepatic enhancing lesion with associated bile duct stricture was identified in a 25-year-old woman with a history of primary sclerosing cholangitis (PSC) who was being evaluated for increasing liver enzymes. Partial hepatectomy was performed, revealing a composite tumor with neuroendocrine and cholangiocarcinomatous differentiation. Only one composite tumor of the liver has been previously reported in the literature [H. Hidaka, S. Kuwao, S. Kokubu, K. Yanagimoto, A. Satomichi, M. Takada, T. Nakazawa, K. Saigenji, Mixed carcinoid-adenocarcinoma of the liver, Intern. Med. 39 (2000) 910-913], and to our knowledge, this is the first report of such a tumor in association with PSC. We report this very unusual case and discuss the potential association of neuroendocrine carcinoma with primary sclerosing cholangitis.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Wisconsin Hospital and Clinics, Madison, WI 53792- 8550, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Koplin
authors.forename: Rashmi
authors.initials: R
authors.lastname: Agni
mesh_terms: D000328:Adult; D018278:Carcinoma, Neuroendocrine / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D015209:Cholangitis, Sclerosing / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D003092:Colitis / Q000150:complications; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000378:metabolism / Q000473:pathology*