[Study on the drug resistance situation among recently infected HIV-1 patients in Dehong].
OBJECTIVE
To study the HIV-1 drug resistance (DR) situation among newly infected persons in Dehong.


METHODS
1048 HIV-1 positive blood samples from July to December in 2006 from Dehong prefecture of Yunnan, were collected. HIV drug resistance were tested using TruGene in newly infected people that were distinguished with BED-CEIA, while the subtype were determined with phylogenetic analysis using a set of reference sequences available on the Los Alamos Database.


RESULTS
Of sixty-four successfully analyzed samples, drug resistance mutations were detected in 4 samples with the resistance rate as 6.25%. Minor mutation in PR region such as M361/V, L63P and H69K appeared frequently and the rates were 81.25%, 70.31% and 65.63% respectively. The predominantly prevalent strains were seen as C/CRF07 _ BC/08 _ BC(65.63%, 42/64) in this study.


CONCLUSIONS
The prevalence of genotypic drug resistances in HIV-1 recent infections in Dehong prefecture appeared to be at moderate level. Drug-resistance surveillance program among HIV-1 infections should be continued and strengthened.
Wang
Min-Jie
MJ
Cancer Hospital & Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100027, China.
Duan
Song
S
Xiang
Li-Fen
LF
Yang
Yue-Cheng
YC
Tu
Yuan-Quan
YQ
Wang
Ji-Bao
JB
Yao
Jun
J
Qi
Jun
J
Jiang
Yan
Y
D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology; D002681:China; D024882:Drug Resistance, Viral / Q000235:genetics*; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000187:drug effects* / Q000235:genetics*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood
D019380:Anti-HIV Agents; D012367:RNA, Viral