title: Unprecedented hemiketal cembranolides with anti-inflammatory activity from the soft coral Lobophytum durum.
abstract: Chemical investigations of the soft coral Lobophytum durum have led to the isolation of three unprecedented hemiketal cembranolides, durumhemiketalolides A-C (1-3). Full NMR spectroscopic assignments are provided for all isolated metabolites. The anti-inflammatory activities of 1-3 were evaluated in vitro.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen UniVersity, Kaohsiung 804, Taiwan, Republic of China.
authors.forename: Shi-Yie
authors.initials: SY
authors.lastname: Cheng
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Shang-Kwei
authors.initials: SK
authors.lastname: Wang
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Chiou
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Chang-Feng
authors.initials: CF
authors.lastname: Dai
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Chiang
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects / Q000201:enzymology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D012477:Salmonella enteritidis / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004224:Diterpenes; C535129:durumhemiketalolide A; C535130:durumhemiketalolide B; C535131:durumhemiketalolide C