title: Outcomes and utilization of kidneys from deceased donors with acute kidney injury.
abstract: Utilization and long-term outcomes of kidneys from donors with elevated terminal serum creatinine (sCr) levels have not been reported. Using data from the Scientific Registry of Transplant Recipients from 1995 to 2007, recipient outcomes of kidneys from adult donors were evaluated stratified by standard criteria (SCD; n = 82 262) and expanded criteria (ECD; n = 16 978) donor type and by sCr </=1.5, 1.6-2.0 and >2.0 mg/dL. Discard rates for SCDs were ascertained. The relative risk of graft loss was similar for recipients of SCD kidneys with sCr of 1.6-2.0 and >2.0 mg/dL, compared to </=1.5 mg/dL. For ECD recipients, the relative risk of graft failure significantly increased with increasing sCr. Of potential SCDs, the adjusted risk of discard was higher with sCr >2.0 mg/dL (adjusted odds ratio [AOR] 7.04, 95% confidence interval [CI] 6.5-7.6) and 1.6-2.0 mg/dL (AOR 2.7; CI 2.5-2.9) relative to sCr </=1.5 mg/dL. Among potential SCDs, elevated terminal creatinine is a strong independent risk factor for kidney discard; yet, when kidney transplantation is performed elevated donor terminal creatinine is not a risk factor for graft loss. Further research is needed to identify safe practices for the optimal utilization of SCD kidneys from donors with acute kidney injury.
authors.affiliation: Shands Hospital at the University of Florida, Gainesville, FL, USA. liisekayler@yahoo.com
authors.forename: L K
authors.initials: LK
authors.lastname: Kayler
authors.forename: P
authors.initials: P
authors.lastname: Garzon
authors.forename: J
authors.initials: J
authors.lastname: Magliocca
authors.forename: S
authors.initials: S
authors.lastname: Fujita
authors.forename: R D
authors.initials: RD
authors.lastname: Kim
authors.forename: A W
authors.initials: AW
authors.lastname: Hemming
authors.forename: R
authors.initials: R
authors.lastname: Howard
authors.forename: J D
authors.initials: JD
authors.lastname: Schold
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function; D046148:Donor Selection; D005260:Female; D006085:Graft Survival / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016030:Kidney Transplantation / Q000706:statistics & numerical data*; D008297:Male; D016017:Odds Ratio; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D003404:Creatinine