Current approaches to the evaluation and management of the fetus and neonate with immune thrombocytopenia.
Fetal and neonatal alloimmune thrombocytopenia is not a well-known disease, except among specialists in maternal-fetal medicine, neonatologists, and certain pediatricians (ie, hematologists). However, this is by far the most common cause of early severe thrombocytopenia in neonates and of intracranial hemorrhage in term neonates. In addition, if a newborn is affected with alloimmune thrombocytopenia, the next child in the family will likely be more severely affected. Thus, the accurate diagnosis and appropriate management of this disorder are of extreme importance in perinatal medicine and will constitute the focus of this review.
Bussel
James B
JB
Division of Pediatric Hematology Oncology, Weill Cornell Medical College/New York-Presbyterian Hospital, New York, NY 10065, USA. Jbussel@med.cornell.edu
Sola-Visner
Martha
M
D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*; D005333:Fetus; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007231:Infant, Newborn; D010976:Platelet Count; D017713:Platelet Transfusion; D011247:Pregnancy; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*
D016756:Immunoglobulins, Intravenous