title: [Recent developments in biopsy diagnosis of early and undefined liver tumors].
abstract: Biopsy diagnosis of early and highly differentiated liver tumors is difficult and complex. Modern pathology has met this challenge by several different means; elaborate morphological algorithms and novel immunohistological markers support the differential diagnosis of highly differentiated HCC and a new, predictive molecular pathological and histological classification of liver cell adenoma was developed. By these new diagnostic tools together with the so-called 'matrix diagnosis' a reliable diagnostic classification is now feasible in the vast majority of these difficult cases.
authors.affiliation: Pathologisches Institut, Universität Heidelberg, Heidelberg.
authors.forename: T
authors.initials: T
authors.lastname: Longerich
authors.forename: P
authors.initials: P
authors.lastname: Schirmacher
mesh_terms: D018248:Adenoma, Liver Cell / Q000145:classification / Q000473:pathology*; D000465:Algorithms; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000145:classification / Q000473:pathology*; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D020518:Focal Nodular Hyperplasia / Q000145:classification / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000145:classification / Q000473:pathology*; D011230:Precancerous Conditions / Q000145:classification / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor