title: A simple, versatile, low-cost and remotely operated apparatus for [11C]acetate, [11C]choline, [11C]methionine and [11C]PIB synthesis.
abstract: A simple, efficient and remotely operated synthesis apparatus for carrying out routine [(11)C]carboxylation, on-column and bubbling [(11)C]methylation was essential for reliable, day-to-day production of [(11)C]-labelled PET radiopharmaceuticals. We developed an in-house apparatus specifically applied to the synthesis of [(11)C]acetate, [(11)C]choline, [(11)C]methionine and 2-(4'-N-[(11)C]methylaminophenyl)-6-hydroxybenzothiazole ([(11)C]PIB), where high radiochemical purity (>or= 97%) and moderate radiochemical yields (18% for [(11)C]PIB, 41-55% for the others) could be achieved. These findings provided evidence that this was a fast, versatile and reliable apparatus suitable for a PET/CT centre with limited financial budget and hot cell space for synthesis of [(11)C]-labelled radiopharmaceuticals.
authors.affiliation: Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2-4 Village Road, Happy Valley, Hong Kong. jackycheung@hksh.com
authors.forename: Man-ki
authors.initials: MK
authors.lastname: Cheung
authors.forename: Chi-lai
authors.initials: CL
authors.lastname: Ho
mesh_terms: D000085:Acetates / Q000138:chemical synthesis*; D000814:Aniline Compounds; D052160:Benzothiazoles / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes / Q000737:chemistry*; D002794:Choline / Q000138:chemical synthesis*; D008715:Methionine / Q000138:chemical synthesis*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000085:Acetates; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D019275:Radiopharmaceuticals; D013844:Thiazoles; D008715:Methionine; D002794:Choline