[Study on biligustilides from Angelica sinensis].
OBJECTIVE
To study the chemical constituents of Angelica sinensis.


METHODS
The constituents were separated by chromatographic methods, and their structures were identified on the basis of spectroscopic analysis.


RESULTS
Eight compounds were isolated and identified as levistolide A (1), senkyunolide O (2), (3Z, 3Z')-6.8', 7.3'-diligustilide (3), tokinolide B (4), isotokinolide B (5), (3'Z)-(3R, 8S, 3a'R, 6'S)-3, 3a': 8, 6'-biligustilide (6), E, E'-3. 3', 8. 8'-diligustilide (7) and E, E'-3. 3', 8. 8'-isodiligustilide (8), which are all diligustilides.


CONCLUSIONS
Compound 7 was obtained from the plant for the first time; compounds 6 and 8 are new compounds.
Lu
Xin-Hua
XH
Department of Natural Medicines, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100083, China.
Zhang
Jin-Juan
JJ
Zhang
Xue-Xia
XX
Liang
Hong
H
Zhao
Yu-Ying
YY
D029971:Angelica sinensis / Q000737:chemistry*; D001572:Benzofurans / Q000737:chemistry; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015394:Molecular Structure
D001572:Benzofurans; D004365:Drugs, Chinese Herbal; C523615:levistolide A; C045855:3-N-butyl-4,5-dihydrophthalide