title: Oxethazaine as the source of mephentermine and phentermine in athlete's urine.
abstract: The urine specimens of numerous athletes were found to be positive for mephentermine both in-competition and out-of-competition in Taiwan. The donor of one specimen claimed she had only taken Mucaine (contains oxethazaine) for relieving symptomatic peptic ulcer and gastritis. Oxethazaine is not included in the prohibited list of the World Anti-Doping Agency; however, its metabolized compounds, mephentermine and phentermine, are included in that list. This study applied LC-MS-MS to analyze the excretions of three volunteers who ingested oxethazaine and presented positive results for mephentermine and/or phentermine. Thus, oxethazaine is the source of mephentermine and phentermine. Moreover, the results showed that 48 brands of gastric medicines containing oxethazaine were legally imported or locally manufactured in Taiwan, information which could be useful for limiting the misuse of oxethazaine by athletes. The data suggested that the sports associations should warn athletes about the risks of taking oxethazaine.
authors.affiliation: Graduate Institute of Sports Science, National Taiwan Sport University, 250, Wen-Hua 1st Rd., Kweishan, Taoyuan County 333, Taiwan, ROC. meichich1224@mail2000.com.tw
authors.forename: Mei-Chich
authors.initials: MC
authors.lastname: Hsu
authors.forename: Su-Fan
authors.initials: SF
authors.lastname: Lin
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Kuan
authors.forename: Wei-Lan
authors.initials: WL
authors.lastname: Chu
authors.forename: Kuei-Hui
authors.initials: KH
authors.lastname: Chan
authors.forename: Guo-Ping
authors.initials: GP
authors.lastname: Chang-Chien
mesh_terms: D000863:Antacids / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D000697:Central Nervous System Stimulants / Q000737:chemistry / Q000652:urine; D002853:Chromatography, Liquid; D004300:Doping in Sports; D004983:Ethanolamines / Q000737:chemistry* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D013058:Mass Spectrometry; D008616:Mephentermine / Q000737:chemistry / Q000652:urine*; D015394:Molecular Structure; D010645:Phentermine / Q000737:chemistry / Q000652:urine*; D013566:Sympathomimetics / Q000737:chemistry / Q000652:urine; D013624:Taiwan
chemical_list: D000863:Antacids; D000697:Central Nervous System Stimulants; D004983:Ethanolamines; D013566:Sympathomimetics; D010645:Phentermine; C100289:oxethazaine; D008616:Mephentermine