Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.
Novel cinnamoyl and caffeoyl clusters were synthesized by multiple Cu(I)-catalyzed [1,3]-dipolar cycloadditions and their anti-5-lipoxygenase inhibitory activity was tested. Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the best 5-lipoxygenase inhibitory activity.
Doiron
Jérémie
J
Department of Chemistry and Biochemistry, Université de Moncton, Moncton, NB, Canada E1A 3E9.
Boudreau
Luc H
LH
Picot
Nadia
N
Villebonet
Benoît
B
Surette
Marc E
ME
Touaibia
Mohamed
M
D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002934:Cinnamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D002109:Caffeic Acids; D002934:Cinnamates; D016859:Lipoxygenase Inhibitors; D014230:Triazoles; C040048:caffeic acid