Recent advances in enhancing the sensitivity of electrophoresis and electrochromatography in capillaries and microchips (2006-2008).
Poor sensitivity is still considered to be one of the major limitations of electrophoresis, which is surprising given the power, flexibility and versatility of many of the approaches to on-line concentration that have developed over the last 20 years. This is still a very active area of interest and this review will cover developments in the field over the last two years since the last review (Electrophoresis 2007, 28, 254-281) through to June 2008. It includes developments in the fields of stacking, covering all methods from field-amplified sample stacking and large volume sample stacking, through to ITP, dynamic pH junction and sweeping. Attention is also given to on-line or in-line extraction methods that have been used for electrophoresis.
Breadmore
Michael C
MC
Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia. mcb@utas.edu.au
Thabano
Jonathan R E
JR
Dawod
Mohamed
M
Kazarian
Artaches A
AA
Quirino
Joselito P
JP
Guijt
Rosanne M
RM
D053801:Capillary Electrochromatography / Q000379:methods*; D005591:Chemical Fractionation; D004586:Electrophoresis; D019075:Electrophoresis, Capillary / Q000379:methods*; D046209:Electrophoresis, Microchip / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D012680:Sensitivity and Specificity; D052616:Solid Phase Extraction