title: A new atisane-type diterpene from the bark of the mangrove plant Excoecaria agallocha.
abstract: A new atisane-type diterpene, ent-16alpha-hydroxy-atisane-3,4-lactone (4) and three known diterpenes, ent-16alpha-hydroxy-atisane-3-one (1), ent-atisane-3beta,16alpha-diol (2), ent-3,4-seco-16alpha-hydroxyatis- 4(19)-en -3-oic acid (3) were isolated from the bark of the mangrove plant Excoecaria agallocha. Their structures and relative stereochemistry were elucidated by means of extensive NMR and MS analysis. Compound 3 exhibited significant anti-microfouling activity against the adherence of Pseudomonas pseudoalcaligenes, with an EC(50) value of 0.54+/-0.01 ppm.
authors.affiliation: Key Laboratory of Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, China.
authors.forename: Zhan Chang
authors.initials: ZC
authors.lastname: Wang
authors.forename: Yi Ming
authors.initials: YM
authors.lastname: Lin
authors.forename: Dan Qin
authors.initials: DQ
authors.lastname: Feng
authors.forename: Cai Huan
authors.initials: CH
authors.lastname: Ke
authors.forename: Peng
authors.initials: P
authors.lastname: Lin
authors.forename: Chong Ling
authors.initials: CL
authors.lastname: Yan
authors.forename: Jun De
authors.initials: JD
authors.lastname: Chen
mesh_terms: D000818:Animals; D018441:Biofilms; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry*
chemical_list: D004224:Diterpenes