title: Novel homo-bimetallic complexes of [N(10)] macrocyclic ligand modified with tetrapeptide function: biological activities, spectral and cyclic voltammetric studies.
abstract: The bimetallic complexes [M(2)LCl(4)] (M=Cr, Co, Ni, Cu) prepared via metal template cyclization reactions were characterized by physico-chemical and spectroscopic methods. L is a 30-membered [N(10)] macrocycle with tetraamide functions bind metal ions through aza donors forming hexa-coordinate geometry. The perspective view and important structural parameters have been computed from the molecular model (MOPAC) method. The electrochemical studies indicate existence of quasi-reversible redox couples in solution. The metal complexes were screened (in vitro) against a few pathogenic fungi and bacteria to assess their growth inhibiting potential.
authors.affiliation: Coordination Chemistry Research Group, Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. zafarsiddiqi@yahoo.co.in
authors.forename: Zafar A
authors.initials: ZA
authors.lastname: Siddiqi
authors.forename: Sarvendra
authors.initials: S
authors.lastname: Kumar
authors.forename: Mohd
authors.initials: M
authors.lastname: Khalid
authors.forename: M
authors.initials: M
authors.lastname: Shahid
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D003500:Cyclization; D004563:Electrochemistry; D008024:Ligands; D008670:Metals / Q000737:chemistry / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D008024:Ligands; D008670:Metals; D010455:Peptides