A chemical epigenetics approach for engineering the in situ biosynthesis of a cryptic natural product from Aspergillus niger.
A new fungal metabolite, nygerone A (), featuring a unique 1-phenylpyridin-4(1H)-one core that had previously not been reported from any natural source, has been obtained from Aspergillus niger using a chemical epigenetics methodology.
Henrikson
Jon C
JC
Natural Products Discovery Group, Department of Chemistry and Biochemistry, 620 Parrington Oval, Room 208, University of Oklahoma, Norman, Oklahoma, 73019-3032, USA.
Hoover
Ashley R
AR
Joyner
P Matthew
PM
Cichewicz
Robert H
RH
D001234:Aspergillus niger / Q000235:genetics* / Q000378:metabolism*; D001593:Benzyl Compounds / Q000378:metabolism*; D001688:Biological Products / Q000096:biosynthesis*; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D044127:Epigenesis, Genetic / Q000187:drug effects*; D005818:Genetic Engineering / Q000379:methods*; D056572:Histone Deacetylase Inhibitors; D009682:Magnetic Resonance Spectroscopy; D011728:Pyridones / Q000378:metabolism*
D001593:Benzyl Compounds; D001688:Biological Products; D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D011728:Pyridones; C538955:nygerone A