title: [Stresses in portal venous system of pre-hepatic portal hypertension (PHT) rabbits].
abstract: Portal hypertension is a common physiopathological change in liver cirrhosis. In this study, rabbits were used and the model of pre-hepatic portal hypertension (PHT) was induced by partial ligation of portal vein in two steps. We measured the diameters of portal vein and small mesenteric vein at different time-points. Then we detected the stress forces induced by blood flow in varicose veins and in portal vein; such forces included hydrostatic pressure, shear stress and circumferential stress. With the increase of the diameter of varicose small mesenteric vein, the hydrostatic pressure and circumferential stress gradually elevated and shear stress descended markedly in both the portal vein and the small mesenteric vein of PHT rabbits, between which there was a positive linear correlation. The findings in our study indicate that the complications of PHT are partially attributable to the environment of lower shear stress and higher circumferential stress in which the blood vessels of portal venous system live.
authors.affiliation: Department of Gastroenterology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
authors.forename: Zongqi
authors.initials: Z
authors.lastname: Zhang
authors.forename: Songwei
authors.initials: S
authors.lastname: Tang
authors.forename: Liang
authors.initials: L
authors.lastname: Zhu
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Wu
authors.forename: Zonglai
authors.initials: Z
authors.lastname: Jiang
authors.forename: Bin
authors.initials: B
authors.lastname: Shi
mesh_terms: D000818:Animals; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D008642:Mesenteric Veins / Q000473:pathology / Q000503:physiopathology*; D011169:Portal Vein / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits; D013314:Stress, Mechanical; D014655:Vascular Resistance / Q000502:physiology*; D014690:Venous Pressure