Insights into the cellular role of enigmatic DNA polymerase iota.
It has been a decade since the discovery of human DNA polymerase iota (poliota). Since that time, the enzyme has been characterized extensively at the biochemical level, but the cellular function of poliota remains enigmatic. Recent studies on poliota have, however, provided much needed insights into its biological role(s) and suggest that the enzyme plays important functions in protecting humans from the deleterious consequences of exposure to both oxidative- and ultraviolet light-induced DNA damage.
Vidal
Antonio E
AE
Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Armilla, Granada, Spain.
Woodgate
Roger
R
D000818:Animals; D004247:DNA / Q000378:metabolism / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair; D004259:DNA-Directed DNA Polymerase / Q000502:physiology*; D006801:Humans; D051379:Mice; D018384:Oxidative Stress / Q000235:genetics; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D012509:Sarcoma / Q000235:genetics / Q000378:metabolism; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity; D014466:Ultraviolet Rays / Q000009:adverse effects; D000094769:DNA Polymerase iota
D018809:Proliferating Cell Nuclear Antigen; D004247:DNA; D004259:DNA-Directed DNA Polymerase; D000094769:DNA Polymerase iota