title: Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements.
abstract: Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has the potential for broad clinical application. We present a simple, compact system using off-axis integrated cavity output spectroscopy with an interband cascade laser and demonstrate its use in real-time measurements of breath ethane. We demonstrate a detection sensitivity of 0.48 ppb/Hz(1/2).
authors.affiliation: Physical Sciences Incorporated, 20 New England Business Center, Andover, Massachusetts 01810, USA. krp@psicorp.com
authors.forename: Krishnan R
authors.initials: KR
authors.lastname: Parameswaran
authors.forename: David I
authors.initials: DI
authors.lastname: Rosen
authors.forename: Mark G
authors.initials: MG
authors.lastname: Allen
authors.forename: Alan M
authors.initials: AM
authors.lastname: Ganz
authors.forename: Terence H
authors.initials: TH
authors.lastname: Risby
mesh_terms: D001944:Breath Tests / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D004980:Ethane / Q000032:analysis*; D006801:Humans; D007834:Lasers; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013055:Spectrophotometry, Infrared / Q000295:instrumentation* / Q000379:methods; D018511:Systems Integration
chemical_list: D004980:Ethane