title: Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod.
abstract: Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.
authors.affiliation: Department of Dermatology, Yeditepe University School of Medicine, Istanbul, Turkey. emelerkek@hotmail.com
authors.forename: E
authors.initials: E
authors.lastname: Erkek
authors.forename: H
authors.initials: H
authors.lastname: Basar
authors.forename: O
authors.initials: O
authors.lastname: Bozdogan
authors.forename: M C
authors.initials: MC
authors.lastname: Emeksiz
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D000284:Administration, Oral; D000287:Administration, Topical; D000634:Aminoquinolines / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004359:Drug Therapy, Combination; D006801:Humans; D000077271:Imiquimod; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*
chemical_list: D000634:Aminoquinolines; D007641:Keratolytic Agents; D017255:Acitretin; D000077271:Imiquimod