title: H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): a prospective cohort study.
abstract: Monoclonal gammopathy of unknown significance (MGUS) is a chronic haematological alteration that carries a 1% risk per year of malignant evolution. The origin of this disturbance remains unknown. Previous reports have suggested that a subgroup of patients presenting MGUS might cure after Helicobacter pylori eradication. This study evaluates the effect of H. pylori eradication in a cohort of 30 patients with MGUS. A 7-day clarithromycin-based triple treatment was prescribed to patients with MGUS infected with H. pylori. Quantification of the monoclonal component was performed at inclusion and at least 12 months after treatment. The monoclonal component persisted unchanged in all patients who cured the H. pylori infection.
authors.affiliation: Servei d'Hematologia, Hospital de Sabadell, Institut Universitari Parc Taulí, Universitat Autónoma de Barcelona, Sabadell, Barcelona, Spain. jsoler@tauli.cat
authors.forename: Juan-Alfonso
authors.initials: JA
authors.lastname: Soler
authors.forename: Mercé
authors.initials: M
authors.lastname: Güell
authors.forename: Meritxell
authors.initials: M
authors.lastname: Bricullé
authors.forename: Antoni
authors.initials: A
authors.lastname: Gavarró
authors.forename: Imma
authors.initials: I
authors.lastname: Roig
authors.forename: Jordi
authors.initials: J
authors.lastname: Sanchez
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
authors.forename: Pilar
authors.initials: P
authors.lastname: García
authors.forename: Albert
authors.initials: A
authors.lastname: Villoria
authors.forename: Xavier
authors.initials: X
authors.lastname: Calvet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017291:Clarithromycin / Q000008:administration & dosage*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000188:drug therapy / Q000276:immunology* / Q000821:virology*; D010266:Paraproteins / Q000032:analysis*; D011446:Prospective Studies; D015203:Reproducibility of Results; D016896:Treatment Outcome
chemical_list: D010266:Paraproteins; D017291:Clarithromycin