title: I405V and TaqIB polymorphisms of the cholesteryl ester transfer protein and their relation to serum lipid and lipoprotein levels in a Turkish population.
abstract: Cholesteryl ester transfer protein (CETP) plays a central role in high-density lipoprotein (HDL) metabolism. Genetic polymorphisms of the CETP gene can influence levels of serum lipoproteins. It has been reported that mean HDL-cholesterol (HDL-C) concentrations are low in Turkish population. Thus, we investigated the frequencies of the common I405V and TaqIB polymorphisms of the CETP gene and their relation to serum lipid and lipoprotein levels in a Turkish population. The variant allele frequencies of I405V and TaqIB polymorphisms of the CETP gene were found to be 0.38 and 0.46, respectively and similar to some of the European populations. Subjects for the VV genotype of I405V polymorphism had higher HDL-C levels than did II subjects. The covariance analysis showed that gender and triglyceride (TG) levels have an effect on the association of HDL-C and I405V polymorphism. In conclusion, our results indicate that I405V polymorphism may affect the HDL-C levels in Turkish population. The association of this polymorphism and HDL-C levels could be modified by other factors, such as gender and TG levels.
authors.affiliation: Department of Biochemistry, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey. sdabbasoglu@yahoo.com
authors.forename: Semra
authors.initials: S
authors.lastname: Doğru-Abbasoğlu
authors.forename: Hande
authors.initials: H
authors.lastname: Parildar-Karpuzoğlu
authors.forename: Bilge
authors.initials: B
authors.lastname: Depboylu
authors.forename: Naci
authors.initials: N
authors.lastname: Cine
authors.forename: Müjdat
authors.initials: M
authors.lastname: Uysal
authors.forename: Gülçin
authors.initials: G
authors.lastname: Aykaç-Toker
mesh_terms: D000328:Adult; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood / Q000235:genetics; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014421:Turkey; D055815:Young Adult
chemical_list: D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D008055:Lipids