title: Health-related quality of life for patients with vasculitis and their spouses.
abstract: OBJECTIVE
  Chronic disease affects both patients and spouses, yet the effect of vasculitis on the spouses of patients has not been systematically examined. We addressed this research gap by describing 8 dimensions of health-related quality of life (HRQOL) for antineutrophil cytoplasmic antibody-associated vasculitis (AAV) patients and their spouses and compared patients and spouses with norms for the general US population. We also determined whether the impact of AAV on HRQOL differs by sex for patients or their spouses.
  
  
  METHODS
  Ninety-seven patients with AAV and their spouses completed a mailed questionnaire that included demographic information and a measure of HRQOL (Medical Outcomes Study Short Form 36.) Using the RAND method, we calculated 8 HRQOL dimensions: general health, physical functioning, emotional role limitations, physical role limitations, social functioning, mental health, bodily pain, and energy/vitality. Using norm-based scores, we compared the HRQOL of patients and spouses with the general US population. We then used multivariate analysis of covariance (MANCOVA) test for sex differences in HRQOL for patients and spouses.
  
  
  RESULTS
  Patients with AAV scored lower than the US norm on all HRQOL subscales with the exception of bodily pain. In contrast, spouses scored similarly to national norms. When age, education, race, illness duration, and disease severity were controlled, there were no significant sex differences in HRQOL for patients or spouses.
  
  
  CONCLUSIONS
  AAV negatively impacts HRQOL for patients; whereas, spouses do not appear to be as negatively impacted. Long-term marriages may attenuate the effect of sex on HRQOL. Quality of life should be assessed throughout the disease course for both patients and spouses.
authors.affiliation: University of North Carolina, Chapel Hill, NC 27599, USA. dlmiller@email.unc.edu
authors.forename: Delesha M
authors.initials: DM
authors.lastname: Carpenter
authors.forename: Carolyn T
authors.initials: CT
authors.lastname: Thorpe
authors.forename: Megan
authors.initials: M
authors.lastname: Lewis
authors.forename: Robert F
authors.initials: RF
authors.lastname: Devellis
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hogan
mesh_terms: D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic; D015267:Churg-Strauss Syndrome / Q000523:psychology; D015331:Cohort Studies; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012737:Sex Factors; D018454:Spouses / Q000523:psychology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic