title: Intraosseous schwannoma of rib.
abstract: A case of intraosseous schwannoma of rib is presented. A 22-year-old woman was admitted with paroxysmal thoracic pain, unproductive cough and a hard mass of the thorax. CT scan showed a unilocular osteolystic lesion in the rib. A needle biopsy was performed, and a diagnosis of intraosseous schwannoma was made. The patient underwent a partial excision of rib and the tumour was removed. Macroscopic examination revealed a 4 x 2 x 1.5 cm solid lesion with destruction of bone. Microscopically, the tumour showed typical features of schwannoma characterised by Antoni A and Antoni B tissues and Verocay bodies. Immunohistochemically, the tumour was positive for S-100 protein, vimentin, neuron specific enolase (NSE) and glial fibrillary acidic protein (GFAP). The patient is well without local recurrence or metastasis after a 1-year follow-up. This is believed to be the second case report of primary schwannoma of rib.
authors.affiliation: Institute of Pathology, Southwest Hospital, The Third Military Medical University, Chongqing, China.
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: Q N
authors.initials: QN
authors.lastname: Guo
authors.forename: R
authors.initials: R
authors.lastname: Zhang
authors.forename: P
authors.initials: P
authors.lastname: Cai
authors.forename: X C
authors.initials: XC
authors.lastname: Yan
mesh_terms: D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009442:Neurilemmoma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012272:Ribs / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed; D055815:Young Adult