title: Successful co-administration of a human rotavirus and oral poliovirus vaccines in Bangladeshi infants in a 2-dose schedule at 12 and 16 weeks of age.
abstract: Co-administration of oral live-attenuated human rotavirus vaccine RIX4414 (Rotarix) and oral polio vaccine (OPV) was assessed. Healthy infants were randomised to receive 2-doses of either: RIX4414 or placebo co-administered with OPV (12 and 16 weeks of age); or RIX4414 or placebo given 15 days after OPV. After vaccination, 56.5-66.7% of RIX4414 and 18.6% of placebo recipients had seroconverted for rotavirus IgA. No significant differences between RIX4414 groups with or without OPV co-administration were observed. No statistically significant differences were observed between groups for polio seroprotection rates. RIX4414 vaccine was immunogenic when co-administered with OPV and did not interfere with OPV seroprotection rates.
authors.affiliation: International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR, B), GPO Box-128, Mohakhali, Dhaka 1000, Bangladesh.
authors.forename: K
authors.initials: K
authors.lastname: Zaman
authors.forename: D A
authors.initials: DA
authors.lastname: Sack
authors.forename: M
authors.initials: M
authors.lastname: Yunus
authors.forename: S E
authors.initials: SE
authors.lastname: Arifeen
authors.forename: G
authors.initials: G
authors.lastname: Podder
authors.forename: T
authors.initials: T
authors.lastname: Azim
authors.forename: S
authors.initials: S
authors.lastname: Luby
authors.forename: R F
authors.initials: RF
authors.lastname: Breiman
authors.forename: K
authors.initials: K
authors.lastname: Neuzil
authors.forename: S K
authors.initials: SK
authors.lastname: Datta
authors.forename: A
authors.initials: A
authors.lastname: Delem
authors.forename: P V
authors.initials: PV
authors.lastname: Suryakiran
authors.forename: H L
authors.initials: HL
authors.lastname: Bock
mesh_terms: D000284:Administration, Oral; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D001459:Bangladesh / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005759:Gastroenteritis / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D011051:Poliomyelitis / Q000276:immunology; D023321:Poliovirus Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D012400:Rotavirus Infections / Q000453:epidemiology / Q000276:immunology*; D022243:Rotavirus Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000914:Antibodies, Viral; D023321:Poliovirus Vaccines; D022243:Rotavirus Vaccines