Effect of Tectona grandis Linn. on dexamethasone-induced insulin resistance in mice.
BACKGROUND
The bark of Tectona grandis Linn. is traditionally used in the treatment of diabetes.


OBJECTIVE
The present study was undertaken to investigate the effect of ethanolic extract of bark of Tectona grandis Linn. (TG) in dexamethasone-induced insulin resistance in mice.


METHODS
Mice were treated with prestandardised dose of dexamethasone for 22 days and effect of TG at the doses of 50, 100 and 200 mg/kg, p.o. on plasma blood glucose level, serum triglyceride level, glucose uptake in skeletal muscle, levels of hepatic antioxidant enzymes (GSH, SOD, catalase and LPO), and body weight were observed.


RESULTS
TG showed significant decrease in plasma glucose and serum triglyceride levels (p<0.01) at the dose of 100 and 200 mg/kg, p.o. and also stimulated glucose uptake in skeletal muscle. The levels of antioxidant enzymes GSH, SOD, and catalase were significantly increased (p<0.01) and there was significant decrease (p<0.01) in level of LPO.


CONCLUSIONS
Hence it can be concluded that Tectona grandis may prove to be effective in the treatment of Type-II Diabetes mellitus owing to its ability to decrease insulin resistance.
Ghaisas
Mahesh
M
Department of Pharmacology, Padm. Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune 411018, India. ghaisasmm@yahoo.com
Navghare
Vijay
V
Takawale
Abhijit
A
Zope
Vinit
V
Tanwar
Mukesh
M
Deshpande
Avinash
A
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D003907:Dexamethasone; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control*; D003964:Diaphragm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007333:Insulin Resistance; D008099:Liver / Q000201:enzymology; D051379:Mice; D008517:Phytotherapy; D000077205:Pioglitazone; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D045162:Thiazolidinediones / Q000494:pharmacology / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood; D029648:Verbenaceae
D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D045162:Thiazolidinediones; D014280:Triglycerides; D003907:Dexamethasone; D000077205:Pioglitazone