title: Diffusion of macromolecules in model oral biofilms.
abstract: The diffusive penetration of fluorescently tagged macromolecular solutes into model oral biofilms was visualized by time-lapse microscopy. All of the solutes tested, including dextrans, proteases, green fluorescent protein, and immunoglobulin G, accessed the interior of cell clusters 100 to 200 microm in diameter within 3 min or less.
authors.affiliation: Division of Cariology, Niigata University, Niigata, Japan.
authors.forename: Shoji
authors.initials: S
authors.lastname: Takenaka
authors.forename: Betsey
authors.initials: B
authors.lastname: Pitts
authors.forename: Harsh M
authors.initials: HM
authors.lastname: Trivedi
authors.forename: Philip S
authors.initials: PS
authors.lastname: Stewart
mesh_terms: D018441:Biofilms; D004058:Diffusion; D005453:Fluorescence; D046911:Macromolecular Substances / Q000378:metabolism*; D018715:Microscopy, Video
chemical_list: D046911:Macromolecular Substances