title: Duration of untreated prodromal symptoms and 12-month functional outcome of individuals at risk of psychosis.
abstract: Individuals seeking help from prodromal services may have been experiencing attenuated psychotic features and psychosocial impairments for a long period prior to referral. The effect of an extended duration of these untreated ;at risk' symptoms on patients' long-term functional outcome was assessed in a 12-month longitudinal observational study (n=49). A longer duration of untreated ;at risk' symptoms was correlated with a reduced improvement in Global Assessment of Functioning scores after 12 months (beta=-0.375, P=0.008). This effect was independent of age and gender and may have implications for the improvement of treatment strategies in pre-psychotic phases.
authors.affiliation: OASIS, South London and Maudsley NHS Trust, and Institute of Psychiatry, King's College London, UK. p.fusar@libero.it
authors.forename: P
authors.initials: P
authors.lastname: Fusar-Poli
authors.forename: A
authors.initials: A
authors.lastname: Meneghelli
authors.forename: L
authors.initials: L
authors.lastname: Valmaggia
authors.forename: P
authors.initials: P
authors.lastname: Allen
authors.forename: F
authors.initials: F
authors.lastname: Galvan
authors.forename: P
authors.initials: P
authors.lastname: McGuire
authors.forename: A
authors.initials: A
authors.lastname: Cocchi
mesh_terms: D000293:Adolescent; D000328:Adult; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000517:prevention & control / Q000523:psychology; D012017:Referral and Consultation / Q000706:statistics & numerical data*; D012569:Schizotypal Personality Disorder / Q000453:epidemiology*; D055815:Young Adult