Somatic and psychological factors related to the body mass index of patients with anorexia nervosa.
OBJECTIVE
The aim of this study was to examine somatic and psychological factors related to the body mass index (BMI) of anorexia nervosa (AN) patients.


METHODS
The analysis was of 24 hospitalized AN patients from the day after admission to the 4th day. The somatic factors analyzed were duration of AN, daily food intake, eating regulatory substances in blood (acylated ghrelin, desacyl ghrelin, leptin), serum cortisol, insulin and estimated creatinine clearance (CCr). The psychological factors analyzed were depression, anxiety, Eating Disorder Inventory (EDI), and hunger/fullness feeling. Measurement of BMI and collection of blood samples were done on the morning after hospitalization. Statistical analysis was by multiple linear regression analysis.


RESULTS
BMI showed a reverse correlation with desacyl ghrelin (beta=-0.486, p=0.015) and maturity fears (beta=-0.375, p=0.046), but was not associated with any other factor by multiple regression analysis.


CONCLUSIONS
The results suggest that desacyl ghrelin and maturity fears play important roles in the prolonged malnutrition state seen in AN patients.
Kawai
K
K
Department of Psychosomatic Medicine, Graduate School of Medical Science, Kyushu University, Higashi-ku, Fukuoka, Japan. kawai@cephal.med.kyushu-u.ac.jp
Yamanaka
T
T
Yamashita
S
S
Gondo
M
M
Morita
C
C
Arimura
C
C
Nozaki
T
T
Takii
M
M
Kubo
C
C
D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000523:psychology*; D001007:Anxiety / Q000150:complications; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D003863:Depression / Q000150:complications; D004435:Eating; D005239:Fear; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D006815:Hunger; D006854:Hydrocortisone / Q000097:blood; D007297:Inpatients; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood; D016014:Linear Models; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012528:Satiety Response; D013997:Time Factors; D055815:Young Adult
D015415:Biomarkers; D054439:Ghrelin; D007328:Insulin; D020738:Leptin; D003404:Creatinine; D006854:Hydrocortisone