Chaetomugilins, new selectively cytotoxic metabolites, produced by a marine fish-derived Chaetomium species.
Chaetomugilins A-F have been isolated from a strain of Chaetomium globosum originally isolated from the marine fish Mugil cephalus, and their absolute stereostructures have been elucidated on the basis of spectroscopic analyses, including 1D and 2D NMR techniques, some chemical transformations and an X-ray analysis. These compounds exhibited significant growth inhibition against cultured P388 cells and HL-60 cells. In addition, chaetomugilins A, C and F showed selective cytotoxic activities against 39 human cancer cell lines.
Yasuhide
Muroga
M
Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan.
Yamada
Takeshi
T
Numata
Atsushi
A
Tanaka
Reiko
R
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002597:Chaetomium / Q000302:isolation & purification / Q000378:metabolism*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010860:Pigments, Biological / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D023701:Smegmamorpha / Q000382:microbiology*; D013237:Stereoisomerism
D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D005663:Furans; D010860:Pigments, Biological; D011753:Pyrones; C494154:azaphilone; C539431:chaetomugilin D; C539432:chaetomugilin E; C539433:chaetomugilin F