Management of familial hypertriglyceridemia during pregnancy with plasma exchange.
Hypertriglyceridemia-induced pancreatitis is a serious complication of familial dyslipidemias. Hormonal influences during pregnancy can compromise otherwise controlled lipid levels in women with familial hypertriglyceridemia and predispose to pancreatitis leading to increased morbidity in both mother and fetus. We report the successful use of therapeutic plasma exchange (TPE) in the management of hypertriglyceridemia during pregnancy resulting in avoidance of pancreatitis and delivery of a healthy term infant. Thirteen TPEs were performed from 19 to 36 weeks gestation to maintain tight control of triglyceride levels.
Sivakumaran
Praveen
P
Division of Transfusion Medicine, Pathology and Lab Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA. Praveen.Sivakumaran@cshs.org
Tabak
Steven W
SW
Gregory
Kimberly
K
Pepkowitz
Samuel H
SH
Klapper
Ellen B
EB
D000328:Adult; D019468:Disease Management; D005260:Female; D006801:Humans; D015228:Hypertriglyceridemia / Q000188:drug therapy*; D008052:Lipid Metabolism, Inborn Errors / Q000188:drug therapy*; D010195:Pancreatitis / Q000517:prevention & control; D010951:Plasma Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy