Chronic CXCL10 alters neuronal properties in rat hippocampal culture.
The chemokine CXCL10 is expressed in the central nervous system (CNS) during neuroinflammatory conditions. Neurons express CXCR3, the receptor for CXCL10, and neuronal function has been shown to be altered by acute exposure to CXCL10. Little is known about the effects of chronic exposure to CXCL10 on neuronal function. Results from our studies show that chronic exposure of cultured rat hippocampal neurons to CXCL10 results in altered levels of protein for GABA and glutamate receptors and altered synaptic network activity. These effects of CXCL10 may contribute to altered CNS function that occurs in some chronic neuroinflammatory conditions.
Cho
Jungsook
J
Molecular and Integrative Neurosciences Department, The Scripps Research Institute, La Jolla, CA 92037, USA. jscho@dongguk.ac.kr
Nelson
Thomas E
TE
Bajova
Hilda
H
Gruol
Donna L
DL
D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D001418:Baclofen / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D054357:Chemokine CXCL10 / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology*; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D010721:Phosphinic Acids / Q000494:pharmacology; D011412:Propanolamines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism; D018079:Receptors, GABA / Q000276:immunology / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D016704:Synapsins / Q000378:metabolism; D013997:Time Factors
D000906:Antibodies; D054357:Chemokine CXCL10; D018755:GABA Agonists; D018756:GABA Antagonists; D005904:Glial Fibrillary Acidic Protein; D010721:Phosphinic Acids; D011412:Propanolamines; D018091:Receptors, AMPA; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D016704:Synapsins; C085075:CGP 55845A; D016202:N-Methylaspartate; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2; D001418:Baclofen; C104722:glutamate receptor ionotropic, AMPA 2; D002118:Calcium