[Beyond TGF-beta: wound healing modulation in filtering glaucoma surgery].
Conjunctival scarring remains the major problem in filtering glaucoma surgery. Antimetabolites afford a reduction of scar formation, but considerable side effects limit their application. Here, we review the mechanisms and peculiarities of wound healing following glaucoma surgery and report on new developments in the field of wound healing modulation. The growth factor TGF-beta has a central role in wound healing and scarring. Therefore, novel concepts of wound healing modulation comprise scavenging of TGF-beta and specific inhibition of disinct downstream intracellular signalling pathways. Several compounds have entered preclinical evaluation and offer new potential to modulate scarring in future combination therapies.
Meyer-Ter-Vehn
T
T
Augenklinik, Universitätsklinikum Würzburg.
Klink
T
T
Grehn
F
F
Schlunck
G
G
D002921:Cicatrix / Q000188:drug therapy* / Q000209:etiology* / Q000517:prevention & control; D003229:Conjunctival Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000517:prevention & control; D018463:Filtering Surgery / Q000009:adverse effects*; D005901:Glaucoma; D006801:Humans; D016212:Transforming Growth Factor beta / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
D016212:Transforming Growth Factor beta