Fungal chitin-glucan from Aspergillus niger efficiently reduces aortic fatty streak accumulation in the high-fat fed hamster, an animal model of nutritionally induced atherosclerosis.
The effects of chitin-glucan (CG) on early atherosclerosis, cardiac production of superoxide anion, and hepatic antioxidant enzymes were studied in an animal model of atherosclerosis. Three groups of 12 hamsters were fed an atherogenic diet for 12 weeks. They received by gavage either water (control group) or CG in water at a dose of 21.4 mg/kg BW x d-1 of chitin-glucan (CG ld) or 42.8 mg/kg BW x d-1 (GG hd). CG did not affect plasma cholesterol but lowered triglycerides. It also strongly reduced the area of aortic fatty streak deposition by 87-97%, cardiac production of superoxide anion by 25% and liver MDA by 77-85%, and enhanced liver superoxide dismutase activity by 7-45% and glutathionne peroxidase activity by 38-120%. These findings support the view that chronic consumption of chitin-glucan has potential beneficial effects with respect to the development of atherosclerosis. The underlying mechanism is related mainly to improving the antioxidant status.
Berecochea-Lopez
Arlet
A
Université Montpellier 2, Montpellier cedex 5, France.
Decordé
Kelly
K
Ventura
Emilie
E
Godard
Marlène
M
Bornet
Aurélie
A
Teissèdre
Pierre-Louis
PL
Cristol
Jean-Paul
JP
Rouanet
Jean-Max
JM
D000818:Animals; D001011:Aorta / Q000473:pathology*; D001234:Aspergillus niger / Q000737:chemistry*; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002686:Chitin / Q000008:administration & dosage*; D006224:Cricetinae; D004032:Diet; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000008:administration & dosage; D004195:Disease Models, Animal; D005936:Glucans / Q000008:administration & dosage*; D008297:Male; D008647:Mesocricetus
D004041:Dietary Fats; D005936:Glucans; D002686:Chitin