title: Patching retinal breaks with Seprafilm in experimental rhegmatogenous retinal detachment of rabbit eyes.
abstract: OBJECTIVE
  To examine the short-term effect of Seprafilm for patching retinal breaks in experimental rhegmatogenous retinal detachment of rabbit eyes.
  
  
  METHODS
  Experimental retinal detachment with a break was made and repaired by fluid-gas exchange during vitreous surgery in 10 rabbit eyes. In seven eyes, Seprafilm was applied to cover iatrogenic retinal breaks entirely (study group) and in other three eyes operations were finished without Seprafilm application (control group). Funduscopic examination was carried out in both groups and in study group optical coherence tomography (OCT) was performed to observe Seprafilm on the retinal break. Eyes of study group were enucleated on 7th and 14th postoperative day for histological evaluation.
  
  
  RESULTS
  The funduscopic examination showed that the retina was reattached in all eyes of study group. Meanwhile all three eyes of control group resulted in proliferative vitreoretinopathy. OCT showed that Seprafilm adhered to the retina tightly. Funduscopic examination and OCT showed Seprafilm dissolved within 14 days. Histological examination revealed that Seprafilm adhered tightly to the retina and there was no inflammatory change at the Seprafilm application sites.
  
  
  CONCLUSIONS
  In our small number of this study, Seprafilm was found to be beneficial to patch small and posteriorly located retinal breaks in vitreous surgery for rhegmatogenous retinal detachment.
authors.affiliation: Department of Ophthalmology, Kurume University School of Medicine, Kurume, Japan. teruya_kenichi@kurume-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Teruya
authors.forename: J
authors.initials: J
authors.lastname: Sueda
authors.forename: M
authors.initials: M
authors.lastname: Arai
authors.forename: N
authors.initials: N
authors.lastname: Tsurumaru
authors.forename: R
authors.initials: R
authors.lastname: Yamakawa
authors.forename: A
authors.initials: A
authors.lastname: Hirata
authors.forename: T
authors.initials: T
authors.lastname: Hirose
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008567:Membranes, Artificial; D011817:Rabbits; D012160:Retina / Q000473:pathology; D012163:Retinal Detachment / Q000473:pathology; D012167:Retinal Perforations / Q000473:pathology / Q000601:surgery*; D041623:Tomography, Optical Coherence
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid