Exploiting the divergent reactivity of aryl-palladium intermediates for the rapid assembly of fluorene and phenanthrene derivatives.
They all fall down: The value of domino processes can be greatly enhanced when the possibility exists for one to selectively diverge from a common intermediate. In preliminary studies the dual reactivity of aryl-palladium intermediates is exploited. A diverse array of fluorene and phenanthrene derivatives were synthesized in a rapid and efficient manner (see scheme).
Zhao
Ya-Bin
YB
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.
Mariampillai
Brian
B
Candito
David A
DA
Laleu
Benoît
B
Li
Mengzhou
M
Lautens
Mark
M
D002384:Catalysis; D005449:Fluorenes / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D010616:Phenanthrenes / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D005449:Fluorenes; D010616:Phenanthrenes; D010165:Palladium