title: Homologous in vitro fertilization in Turner syndrome: insights from a case report.
abstract: OBJECTIVE
  To describe a bigeminal pregnancy obtained with a homologous intracytoplasmic sperm injection cycle in a patient with high-grade mosaic Turner syndrome (45,XO/47,XXX 97.5%/2.5%) with bicuspid aortic valve.
  
  
  METHODS
  Case report.
  
  
  METHODS
  Unit of Pathophysiology of Human Reproduction in a general hospital.
  
  
  METHODS
  Patient with mosaic Turner syndrome with bicuspid aortic valve.
  
  
  METHODS
  Homologous intracytoplasmic sperm injection cycle after controlled ovarian hyperstimulation with a GnRH agonist flare-up depot protocol and menotropins.
  
  
  METHODS
  Pregnancy development, echocardiographic monitoring of aortic root, karyotypes of progeny.
  
  
  RESULTS
  Ongoing bigeminal pregnancy with the delivery of two healthy infants (46,XX and 46,XY, respectively) by cesarean section without any cardiovascular complication or aortic root echocardiographic modification in the mother.
  
  
  CONCLUSIONS
  Even in patients with Turner syndrome with high-grade 45,XO mosaicism and reduced ovarian reserve, a trial of homologous reproduction should be offered after a thorough cardiologic evaluation to avoid pregnancy-related cardiovascular complications.
authors.affiliation: Maternal-Paediatric Department, Pathophysiology of Human Reproduction and Sperm Bank Unit, Pordenone Hospital, Pordenone, Italy. massimo.manno@aopn.fvg.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Manno
authors.forename: Francesco
authors.initials: F
authors.lastname: Tomei
authors.forename: Marta
authors.initials: M
authors.lastname: Cervi
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Gaspardo
authors.forename: Francesco
authors.initials: F
authors.lastname: Antonini-Canterin
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Nicolosi
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000235:genetics / Q000628:therapy*; D007621:Karyotyping; D009030:Mosaicism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics / Q000503:physiopathology; D011272:Pregnancy, Multiple; D014424:Turner Syndrome / Q000150:complications / Q000235:genetics / Q000503:physiopathology; D014427:Twins