title: Low rates of loco-regional recurrence following extended lymph node dissection for gastric cancer.
abstract: OBJECTIVE
  The study by MacDonald et al. [Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001;345:725-30] has reported low loco-regional recurrence rates (19%) after gastric cancer resection and adjuvant radiotherapy. However, the lymph node dissection was often "inadequate". The aim of this retrospective study is to analyse if an extended lymph node dissection (D2) without adjuvant radiotherapy may achieve comparable loco-regional recurrence rates.
  
  
  METHODS
  A prospective database of 200 patients who underwent a curative resection for gastric carcinoma from January 2000 to December 2006 was analysed. D2 lymph node dissection was standard. Recurrences were categorized as loco-regional, peritoneal, or distant. No patients received neoadjuvant or adjuvant radiotherapy.
  
  
  RESULTS
  The in-hospital mortality rate was 1% (2 patients). The mean number of dissected lymph nodes was 25.9. Overall and disease-free survival at 5years were 60.7% and 61.2% respectively. During the follow-up, 60 patients (30%) have recurred at 76 sites: 38 (50%) distant metastases, 25 (32.9%) peritoneal metastases, and 13 (17.1%) loco-regional recurrences. The loco-regional recurrence was isolated in 6 patients and associated with peritoneal or distant metastases in 7 patients. The mean time to the first recurrence was 18.9 (95% confidence interval: 15.0-21.9) months.
  
  
  CONCLUSIONS
  Extended lymph node dissection is safe and warrants low loco-regional recurrence rates.
authors.affiliation: Division of Surgical Oncology, Istituto per la Ricerca e la Cura del Cancro, Strada Provinciale, Candiolo (TO), Italy. andrea.muratore@ircc.it
authors.forename: A
authors.initials: A
authors.lastname: Muratore
authors.forename: G
authors.initials: G
authors.lastname: Zimmitti
authors.forename: R
authors.initials: R
authors.lastname: Lo Tesoriere
authors.forename: A
authors.initials: A
authors.lastname: Mellano
authors.forename: P
authors.initials: P
authors.lastname: Massucco
authors.forename: L
authors.initials: L
authors.lastname: Capussotti
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D019992:Databases as Topic; D005743:Gastrectomy; D006801:Humans; D008197:Lymph Node Excision / Q000379:methods; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D016019:Survival Analysis