Immune reconstitution inflammatory syndrome.
BACKGROUND
Immune reconstitution inflammatory syndrome (IRIS) is a paradoxical deterioration in clinical status in a patient on antiretroviral treatment (ART) despite satisfactory control of viral replication and improvement of CD4 count.


OBJECTIVE
To study development of IRIS as a part of ART.


METHODS
Hundred patients on antiretroviral treatment were studied prospectively in the Department of Skin and VD over a period of 2 years. Patients were asked to come if they developed any symptoms or on a monthly basis. They were screened clinically and investigated suitably for evidence of opportunistic infections.


RESULTS
Out of 100 patients, 10 patients did not come for follow-up. Twenty (22.2%) out of the 90 patients developed IRIS. Herpes zoster (HZ), herpes simplex virus (HSV), and tuberculosis (TB) were the cases of IRIS seen in the present study.


CONCLUSIONS
IRIS in terms of HSV/TB is known to accelerate HIV disease progression. Hence early detection and prompt treatment, along with continuation of highly active ART, are of utmost importance.
Sharma
Ajay
A
Department of Skin and V.D., Medical College and SSG Hospital, Vadodara, India.
Makrandi
Smita
S
Modi
Megha
M
Sharma
Archana
A
Marfatia
Yogesh
Y
D044966:Anti-Retroviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count / Q000379:methods; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis* / Q000473:pathology*; D011446:Prospective Studies
D044966:Anti-Retroviral Agents