Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.
CD1 proteins constitute a distinct lineage of antigen-presenting molecules specialized for the presentation of lipid antigens to T cells. In contrast to the extensive sequence polymorphism characteristic of classical MHC molecules, CD1 proteins exhibit limited sequence diversity. Here, we describe the identification and characterization of CD1d alleles in wild-derived mouse strains. We demonstrate that polymorphisms in CD1d affect the presentation of endogenous and exogenous ligands to CD1d-restricted T cells, including type I (Valpha14i) and type II (non-Valpha14i) natural killer T (NKT) cells. Using congenic mice, we found CD1d polymorphisms affect the thymic selection of type I NKT cells and induce allogeneic T cell responses. Collectively, results from these studies demonstrate a role for polymorphisms in influencing the development and function of CD1d-restricted T cells.
Zimmer
Michael I
MI
Department of Pathology, University of Chicago, Chicago, IL 60637, USA.
Nguyen
Hanh P
HP
Wang
Bin
B
Xu
Honglin
H
Colmone
Angela
A
Felio
Kyrie
K
Choi
Hak-Jong
HJ
Zhou
Ping
P
Alegre
Maria-Luisa
ML
Wang
Chyung-Ru
CR
D000818:Animals; D017951:Antigen Presentation / Q000235:genetics*; D055610:Antigens, CD1d / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics*; D051379:Mice; D020297:Mice, Congenic; D011110:Polymorphism, Genetic; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D055610:Antigens, CD1d