Alterations in L-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria.
Low-grade inflammation is closely involved in the pathogenesis of type 2 diabetes and associated micro- and macrovascular complications. The nitric oxide (NO) precursor L-arginine, is relevant to diverse pathological conditions including type 2 diabetes and its complications. High sensitive-CRP (hs-CRP), neopterin and arginine levels were measured in 46 normoalbuminuric, 45 microalbuminuric type 2 diabetics and in 32 healthy controls in order to assess the relationship between markers of inflammation and L: -arginine. Hs-CRP concentrations were higher in microalbuminuric diabetic patients compared to normoalbuminuric patients and controls. Diabetics had higher serum and urine neopterin levels than controls. Urine neopterin and L-arginine levels differed significantly among diabetic patients with and without microalbuminuria. There were significant positive correlations between hs-CRP and BMI in healthy controls and diabetics with and without microalbuminuria. In microalbuminuric diabetics, hs-CRP correlated with microalbuminuria (MAU). Significant predictors for the development of microalbuminuria were higher postprandial glucose levels, lower creatinine clearance and lower serum L-arginine levels. Assessment of early markers of inflammation and endothelial function, such as neopterin and NO precursor L-arginine, may help to predict incipient nephropathy more accurately in type 2 diabetic patients.
Bariş
Necla
N
Department of Biochemistry, Ege University School of Medicine, Bornova, Izmir, Turkey.
Erdoğan
Mehmet
M
Sezer
Ebru
E
Saygili
Füsun
F
Mert Ozgönül
A
A
Turgan
Nevbahar
N
Ersöz
Biltan
B
D000419:Albuminuria / Q000097:blood / Q000209:etiology / Q000276:immunology* / Q000652:urine; D001120:Arginine / Q000097:blood*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001786:Blood Glucose; D002097:C-Reactive Protein / Q000032:analysis* / Q000652:urine; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000276:immunology / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019798:Neopterin / Q000032:analysis* / Q000097:blood / Q000652:urine
D015415:Biomarkers; D001786:Blood Glucose; D019798:Neopterin; D002097:C-Reactive Protein; D001120:Arginine