title: Adnexal skin carcinomas of the face.
abstract: Skin adnexal neoplasms are rare tumors, and knowledge on their exact histological development and pathogenesis remains fragmented. Their diagnosis and management are frequently troublesome, especially for malignant tumors. We present a retrospective case series of malignant appendageal tumors of the face. Records of patients with histologically confirmed adnexal skin carcinoma managed at a single department during the period 1995 to 2004 were reviewed. Patient biodata, surgical management, and main outcome measures such as locoregional recurrence, distant metastasis, and disease-free and overall survival were recorded.Eleven patients were identified from record analysis. Lesions were mainly located at the eyelids and the nose. All patients were managed with wide local excision and restoration with local flaps. Two patients showed regional metastasis and underwent radical neck dissection. Nine of 11 patients were alive and free of local and/or regional disease on final follow-up. Two patients died of causes unrelated to the disease. Clinical and histological features, tumor biological behavior, diagnostic difficulties, and recommended management are discussed.In conclusion, adnexal skin tumors should be considered in the differential diagnosis of skin tumors, particularly in view of their more sinister prognosis compared with other nonmelanoma skin tumors. They are acknowledged to demand a more aggressive plan of surgical treatment.
authors.affiliation: Department of Maxillofacial Surgical Oncology, General Hospital G Papanikolaou, Thessaloniki, Greece.
authors.forename: Aris
authors.initials: A
authors.lastname: Ntomouchtsis
authors.forename: Kostas
authors.initials: K
authors.lastname: Vahtsevanos
authors.forename: Anna
authors.initials: A
authors.lastname: Patrikidou
authors.forename: Charalambos
authors.initials: C
authors.lastname: Andreadis
authors.forename: Chrysoula
authors.initials: C
authors.lastname: Tsobanidou
authors.forename: Kostas
authors.initials: K
authors.lastname: Antoniades
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000175:diagnosis; D018280:Carcinoma, Skin Appendage / Q000556:secondary / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis; D015331:Cohort Studies; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005142:Eyelid Neoplasms / Q000601:surgery; D005153:Facial Neoplasms / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000473:pathology; D009669:Nose Neoplasms / Q000601:surgery; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000601:surgery*; D013524:Surgical Flaps; D015996:Survival Rate; D016896:Treatment Outcome