Synthesis, characterization, and DNA-binding studies of mononuclear copper(II)-phenanthroline-tyrosine complex.
The mononuclear complex [Cu(II)(phen)(L-Tyr)(H(2)O)] was synthesized and structurally characterized by elemental analysis, magnetic susceptibility, UV/VIS, IR, and EPR spectroscopy, and ESI mass spectrometry. The electronic and EPR spectral data suggest a square-pyramidal geometry around Cu(II). Absorption spectra, thermal denaturation, and fluorescence-spectroscopic studies were conducted to assess the interaction of the Cu(II) complex with calf thymus DNA (CT DNA). The intrinsic binding constant for CT DNA/complex (K(b)=3750 M(-1)) and Stern-Volmer quenching constant (K=0.39) were determined.
Reddy
Pulimamidi R
PR
Department of Chemistry, Osmania University, Hyderabad-500007, India, (phone: +91-40-27171664; fax: +91-40-27090020).
Manjula
Pallerla
P
D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D009942:Organometallic Compounds; C539328:aqua(phenanthroline)(tyrosine)copper(II); D004247:DNA