Selective determination of ertapenem in the presence of its degradation product.
Stability-indicative determination of ertapenem (ERTM) in the presence of its beta-lactam open-ring degradation product, which is also the metabolite, is investigated. The degradation product has been isolated, via acid-degradation, characterized and elucidated. Selective quantification of ERTM, singly in bulk form, pharmaceutical formulations and/or in the presence of its major degradant is demonstrated. The indication of stability has been undertaken under conditions likely to be expected at normal storage conditions. Among the spectrophotometric methods adopted for quantification are first derivative ((1)D), first derivative of ratio spectra ((1)DD) and bivariate analysis.
Hassan
Nagiba Y
NY
Analytical Chemistry Department, Faculty of Pharmacy, Cairo University, Kasr El-Aini St, ET-11562 Cairo, Egypt.
Abdel-Moety
Ezzat M
EM
Elragehy
Nariman A
NA
Rezk
Mamdouh R
MR
D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D000077727:Ertapenem; D015394:Molecular Structure; D015203:Reproducibility of Results; D013050:Spectrometry, Fluorescence / Q000295:instrumentation / Q000379:methods*; D047090:beta-Lactams / Q000737:chemistry / Q000378:metabolism
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D000077727:Ertapenem