title: Hybrid microprobes for chronic implantation in the cerebral cortex.
abstract: This paper reports on a neural device for chronic implantation into the cerebral cortex. Silicon microprobes with 36 electrodes arranged on four shafts are fabricated using MEMS technology. The hybrid integration of a ribbon cable with high flexibility provides the connection of the electrodes to external instrumentation. Crosstalk between the channels is investigated, as well as the electrode stability for a time period of one month in vitro. Due to the geometry and the mechanical stability of these microprobes, insertions are possible without the need for prior opening of the dura mater. A dedicated insertion tool has been fabricated to achieve a precise insertion of the microprobes and their subsequent mechanical decoupling. Additionally, a protection chamber allowing the secure attachment of two connector units on the skull is introduced. The short-time chronic implantation of microprobes showed that neural activity can be recorded, including single unit activity, which was present after four days.
authors.affiliation: Department of Microsystems Engineering, University of Freiburg, Georges-Koehler-Allee 103, D-79110, Germany. kisban@imtek.de
authors.forename: S
authors.initials: S
authors.lastname: Kisban
authors.forename: P
authors.initials: P
authors.lastname: Janssen
authors.forename: S
authors.initials: S
authors.lastname: Herwik
authors.forename: T
authors.initials: T
authors.lastname: Stieglitz
authors.forename: O
authors.initials: O
authors.lastname: Paul
authors.forename: P
authors.initials: P
authors.lastname: Ruther
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation; D004867:Equipment Design; D008253:Macaca mulatta; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D019736:Prostheses and Implants; D019919:Prosthesis Implantation / Q000295:instrumentation* / Q000379:methods; D012825:Silicon
chemical_list: D012825:Silicon