title: Acute effects of low insulinemic sweeteners on postprandial insulin and glucose concentrations in obese men.
abstract: OBJECTIVE
  This randomized, double-blind, crossover study was designed to assess the effects of trehalose, a non-reducing disaccharide, alone and in combination with fructose, on postprandial serum insulin and glucose levels in obese men compared with a glucose control.
  
  
  METHODS
  Participants (n=21) ingested one of three study beverages, providing 75 g total carbohydrate, at each test visit, and venous blood samples were collected immediately prior to consumption (0 min) and at 30 min, 45 min, 60 min, 90 min, and 120 min post-consumption for assessment of serum insulin and plasma glucose levels.
  
  
  RESULTS
  Consumption of beverages containing trehalose and the trehalose/fructose combination blunted glycemic and insulinemic incremental areas under the curve by 20-35%, as compared with the glucose control.
  
  
  CONCLUSIONS
  Trehalose, alone or in combination with fructose, elicited lower glycemic and insulinemic responses in obese men as compared with glucose alone, and may have advantages in the development of food products.
authors.affiliation: Provident Clinical Research, Glen Ellyn, Illinois, USA.
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Maki
authors.forename: Mitchell
authors.initials: M
authors.lastname: Kanter
authors.forename: Tia M
authors.initials: TM
authors.lastname: Rains
authors.forename: Serena P
authors.initials: SP
authors.lastname: Hess
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Geohas
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005632:Fructose / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology; D038321:Glycemic Index; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D019518:Postprandial Period; D013549:Sweetening Agents / Q000494:pharmacology*; D014199:Trehalose / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D013549:Sweetening Agents; D005632:Fructose; D014199:Trehalose; D005947:Glucose