A preparatively convenient ligand-free catalytic PEG 2000 Suzuki-Miyaura coupling.
A ligand-free Suzuki-Miyaura reaction for the cross-coupling of aryl and heteroaryl bromides with aryl and heteroarylboronic acids has been developed utilizing catalytic polyethylene glycol 2000 (PEG 2000). This preparatively convenient system afforded the corresponding cross-coupled products in good to excellent isolated yields after a simple aqueous workup. Transmission electron microscopy (TEM) analysis of the Pd-PEG 2000 catalyst system revealed in situ-generated palladium nanoparticles after only 1 min of reaction.
Razler
Thomas M
TM
Department of Process Research and Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, USA. thomas.razler@bms.com
Hsiao
Yi
Y
Qian
Feng
F
Fu
Ruiling
R
Khan
Rana Kashif
RK
Doubleday
Wendel
W
D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D001969:Bromobenzenes / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D010165:Palladium / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*
D001713:Biphenyl Compounds; D001897:Boronic Acids; D001969:Bromobenzenes; D008024:Ligands; D011092:Polyethylene Glycols; D010165:Palladium; C010686:benzeneboronic acid