[Neuronal plasticity of otolith-related vestibular system].
This review focuses on our effort in addressing the development and lesion-induced plasticity of the gravity sensing system. After severance of sensory input from one inner ear, there is a bilateral imbalance in response dynamics and spatial coding behavior between neuronal subpopulations on the two sides. These data provide the basis for deranged spatial coding and motor deficits accompanying unilateral labyrinthectomy. Recent studies have also confirmed that both glutamate receptors and neurotrophin receptors within the bilateral vestibular nuclei are implicated in the plasticity during vestibular compensation and development. Changes in plasticity not only provide insight into the formation of a spatial map and recovery of vestibular function but also on the design of drugs for therapeutic strategies applicable to infants or vestibular disorders such as vertigo and dizziness.
Lai
Suk-King
SK
Department of Physiology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Lai
Chun-Hong
CH
Zhang
Fu-Xing
FX
Ma
Chun-Wai
CW
Shum
Daisy K Y
DK
Chan
Ying-Shing
YS
D000818:Animals; D006801:Humans; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D010037:Otolithic Membrane / Q000294:innervation* / Q000502:physiology; D014722:Vestibule, Labyrinth / Q000294:innervation / Q000502:physiology*