title: Outcome of treated anogenital intraepithelial neoplasia among human immunodeficiency virus-infected women.
abstract: OBJECTIVE
  To determine characteristics and clinical course of high-grade anogenital intraepithelial neoplasia (AIN) in human immunodeficiency virus (HIV)-infected women.
  
  
  METHODS
  HIV-positive women with biopsy-proven high-grade (II and III) vulvar (VIN), vaginal (VAIN) or perianal intraepithelial neoplasia (PAIN) were identified in the electronic databases of 2 colposcopy clinics.
  
  
  RESULTS
  A total of 31 patients were identified from 1992 to 2007, of which 30 had a mean follow-up of 47.7 months (SD = 46.0; range, 2.6-166.2). Of the patients, 77.4% had VIN, 12.9% VAIN and 9.7% PAIN at first diagnosis. Age at diagnosis of IN was 36.2 years (SD +/- 5.2; range, 23.5-47.0). Ninety percent of patients received antiretroviral therapy at first diagnosis of IN; 65% (13 of 20) of patients with a follow-up of > 2 years required a second treatment, and 2 developed invasive vulvar cancer (10%).
  
  
  CONCLUSIONS
  AIN among HIV-positive women shows a high relapse rate despite treatment modality used and a substantial invasive potential.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital of Zurich, Zurich, Switzerland. konstantin.dedes@usz.ch
authors.forename: Konstantin J
authors.initials: KJ
authors.lastname: Dedes
authors.forename: Christine
authors.initials: C
authors.lastname: Beneder
authors.forename: Nicolas
authors.initials: N
authors.lastname: Samartzis
authors.forename: Michael D
authors.initials: MD
authors.lastname: Muller
authors.forename: Daniel
authors.initials: D
authors.lastname: Fink
authors.forename: Mathias K
authors.initials: MK
authors.lastname: Fehr
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000150:complications / Q000628:therapy*; D002278:Carcinoma in Situ / Q000150:complications / Q000628:therapy*; D015331:Cohort Studies; D018572:Disease-Free Survival; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D014625:Vaginal Neoplasms / Q000150:complications / Q000628:therapy*; D014846:Vulvar Neoplasms / Q000150:complications / Q000628:therapy*; D055815:Young Adult