title: Curcumin, a polyphenolic antioxidant, attenuates chronic fatigue syndrome in murine water immersion stress model.
abstract: Chronic fatigue syndrome, infection and oxidative stress are interrelated in epidemiological case studies. However, data demonstrating scientific validation of epidemiological claims regarding effectiveness of nutritional supplements for chronic fatigue syndrome are lacking. This study is designed to evaluate the effect of natural polyphenol, curcumin, in a mouse model of immunologically induced fatigue, where purified lipopolysaccharide (LPS) and Brucella abortus (BA) antigens were used as immunogens. The assessment of chronic fatigue syndrome was based on chronic water-immersion stress test for 10 min daily for 19 days and the immobility time was taken as the marker of fatigue. Mice challenged with LPS or BA for 19 days showed significant increase in the immobility time and hyperalgesia on day 19, as well as marked increase in serum tumor necrosis factor-alpha (TNF-alpha) levels. Concurrent treatment with curcumin resulted in significantly decreased immobility time as well as hyperalgesia. There was significant attenuation of oxidative stress as well as TNF-alpha levels. These findings strongly suggest that during immunological activation, there is significant increase in oxidative stress and curcumin can be a valuable option in the treatment of chronic fatigue syndrome.
authors.affiliation: Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160014, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Gupta
authors.forename: Garima
authors.initials: G
authors.lastname: Vij
authors.forename: Sameer
authors.initials: S
authors.lastname: Sharma
authors.forename: Naveen
authors.initials: N
authors.lastname: Tirkey
authors.forename: Praveen
authors.initials: P
authors.lastname: Rishi
authors.forename: Kanwaljit
authors.initials: K
authors.lastname: Chopra
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D000975:Antioxidants / Q000008:administration & dosage*; D002003:Brucella abortus / Q000276:immunology; D030024:Curcuma; D003474:Curcumin / Q000008:administration & dosage*; D004195:Disease Models, Animal; D015673:Fatigue Syndrome, Chronic / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D006930:Hyperalgesia / Q000276:immunology; D007101:Immersion; D046353:Immobility Response, Tonic / Q000187:drug effects; D007114:Immunization; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects / Q000276:immunology; D013312:Stress, Physiological / Q000187:drug effects* / Q000276:immunology; D014110:Touch / Q000187:drug effects / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014867:Water
chemical_list: D000942:Antigens, Bacterial; D000975:Antioxidants; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D014867:Water; D003474:Curcumin