Palliative effect of lafutidine on oral burning sensation.
Lafutidine is a unique histamine H(2)-receptor antagonist (H2RA) that has a sensitizing effect on capsaicin-sensitive afferent neurons (CSAN). This effect may make lafutidine useful for the treatment of burning mouth syndrome (BMS).


METHODS
To evaluate the efficacy and safety of lafutidine in patients with oral burning sensation, a randomized controlled trial was performed. Patients who had been receiving other H2RAs with no sensitizing effect on CSAN were randomly assigned to receive lafutidine 10 mg twice daily for 12 weeks, instead of the previous H2RAs, plus gargling with azulene sulfonate sodium (ASS) (lafutidine group, n = 36) or to continue to receive the previous H2RAs plus ASS gargling (control group, n = 35). The intensity of burning sensation was scored by means of a visual analog scale (VAS).


RESULTS
Thirty-four patients in the lafutidine group and 30 in the control group completed the study. In the lafutidine group, the rate of improvement in the VAS score as compared with the baseline value was significant after 4, 8, and 12 weeks of treatment (P < 0.05). The improvement rate was consistently higher in the lafutidine group than in the control group; the differences between the groups were significant (P < 0.05) after 4, 8, and 12 weeks of treatment. Only two mild abdominal adverse events occurred in the lafutidine group, but neither required the termination of treatment.


CONCLUSIONS
Oral lafutidine is very safe and effective for reducing the intensity of oral burning sensation and may therefore be a viable option for the treatment of BMS.
Toida
M
M
Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan. toida@gifu-u.ac.jp
Kato
K
K
Makita
H
H
Long
N K
NK
Takeda
T
T
Hatakeyama
D
D
Yamashita
T
T
Shibata
T
T
D000081:Acetamides / Q000494:pharmacology / Q000627:therapeutic use*; D000368:Aged; D002054:Burning Mouth Syndrome / Q000188:drug therapy*; D002211:Capsaicin / Q000494:pharmacology; D005260:Female; D006635:Histamine H2 Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009475:Neurons, Afferent / Q000187:drug effects; D010147:Pain Measurement; D010166:Palliative Care; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use*; D011725:Pyridines / Q000494:pharmacology / Q000627:therapeutic use*; D018689:Sensory System Agents / Q000494:pharmacology; D016896:Treatment Outcome
D000081:Acetamides; D006635:Histamine H2 Antagonists; D010880:Piperidines; D011725:Pyridines; D018689:Sensory System Agents; C076948:lafutidine; D002211:Capsaicin