title: Atopic dermatitis and allergic reactions to individual fragrance chemicals.
abstract: BACKGROUND
  Allergic contact dermatitis prevalence is reported as equal in atopic and nonatopic dermatitis. Atopic dermatitis is under-represented in those with allergic contact dermatitis to agents having cutaneous and dietary exposure. We compared rates of atopic dermatitis between patients with allergic contact dermatitis arising out of individual fragrance chemicals with known oral/cutaneous exposure against exclusively cutaneous exposure.
  
  
  METHODS
  Between 1982 and 2007, 37 065 dermatitis patients were tested with Fragrance mix I. Those who were positive were tested for individual fragrance allergy. Chemicals were categorized according to whether their exposure pattern was solely cutaneous, oral or mixed. Current and past atopic dermatitis rates were compared between the whole population and groups allergic to individual fragrances. Age and gender were controlled.
  
  
  RESULTS
  Cinnamic alcohol and cinnamal allergy groups had reduced rates of both 'current' [24/266 (9.0%) P = 0.0008, 38/364 (10.4%) P = 0.0005] and 'past' atopic dermatitis [44/266 (16.5%) P = 0.009, 70/346 (19.2%) P = 0.037]. Atopic dermatitis rates in groups allergic to Evernia prunastri and hydroxycitronellal (cutaneous exposure only) were not reduced [120/597 (20.1%) and 41/153 (26.8%)]. Groups allergic to cinnamic alcohol (P < 0.0001, P < 0.0001) and cinnamal (P < 0.0001, P < 0.004) had reductions in 'current' and 'past' atopic dermatitis, compared with Evernia prunastri.
  
  
  CONCLUSIONS
  Patients allergic to individual fragrances with dietary exposure have reduced rates of atopic dermatitis. This suggests that patients with atopic dermatitis have heightened oral tolerance to dietary haptens, in contrast to the known close association of atopic dermatitis with food-protein allergy. Haptens may interfere with food protein tolerance by binding to soluble protein to alter its configuration and immunogenic profile.
authors.affiliation: Department of Cutaneous Allergy, St John's Institute of Dermatology, St Thomas' Hospital, London.
authors.forename: J M L
authors.initials: JM
authors.lastname: White
authors.forename: I R
authors.initials: IR
authors.lastname: White
authors.forename: I
authors.initials: I
authors.lastname: Kimber
authors.forename: D A
authors.initials: DA
authors.lastname: Basketter
authors.forename: D A
authors.initials: DA
authors.lastname: Buckley
authors.forename: J P
authors.initials: JP
authors.lastname: McFadden
mesh_terms: D000328:Adult; D000485:Allergens / Q000276:immunology; D017449:Dermatitis, Allergic Contact / Q000150:complications / Q000209:etiology*; D003876:Dermatitis, Atopic / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006241:Haptens / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010476:Perfume / Q000009:adverse effects* / Q000737:chemistry; D012189:Retrospective Studies
chemical_list: D000485:Allergens; D006241:Haptens; D010476:Perfume