Strategies to prevent bacterial and fungal infection in the neonatal intensive care unit.
Hospital-acquired infections are one of the leading causes of preventable morbidity and mortality in neonatal intensive care units (NICUs). Device-related infections, such as catheter-associated blood stream infections (CABSIs) and ventilator-associated pneumonia (VAP), are the most common nosocomial infections. This review examines the pathogenesis of CABSIs and methods, widely accepted and novel, that can be used to help prevent them. Strategies to prevent fungal infections, which are often associated with the presence of a central venous catheter, are also reviewed. Finally, the dilemmas in the diagnosis and prevention of VAP in the NICU are discussed.
Garland
Jeffery S
JS
Wheaton Franciscan Health Care, St. Joseph Hospital, 3070 North 51st Street, Suite 309 Milwaukee, WI 53210, USA. 53210.jsgarland@hotmail.com
Uhing
Michael R
MR
D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D002404:Catheterization / Q000009:adverse effects; D002408:Catheters, Indwelling / Q000009:adverse effects; D003428:Cross Infection / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D009181:Mycoses / Q000209:etiology / Q000517:prevention & control*; D053717:Pneumonia, Ventilator-Associated / Q000517:prevention & control