Induction of hepatic peroxisomal beta-oxidation of fatty acids by dehydroepiandrosterone (DHEA) in male F-344 rats.
Pharmacological administration of dehydroepiandrostenone (DHEA, 300 mg/kg, p.o.) for 2 weeks significantly increased (P < 0.01) the activity of hepatic peroxisomal beta-oxidation of fatty acids in male F-344 rats. Similar effects were observed following 8 week administration of DHEA. These results are discussed in the light of oxidative stress-mediated hepatocarcinogenesis.
Khan
S A
SA
Department of Pharmaceutical Sciences, School of Pharmacy, Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA. seherkhan@lecom.edu
D000818:Animals; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D020675:Peroxisomes / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344
D005227:Fatty Acids; D003687:Dehydroepiandrosterone