Oral formulations of budesonide: a novel treatment for inflammatory bowel disease.
Budesonide is a promising drug for a variety of documented applications and has potential in gastroenterology. Its unique local mechanism of delivery and efficient first-pass metabolism, resulting in fewer systemic adverse effects than with conventional glucocorticoids, makes this a desirable drug for clinical practice. This drug has shown promise in treating a wide spectrum of inflammatory diseases from inflammatory bowel disease and other colitides to autoimmune liver diseases. Future research should focus on ways to increase delivery methods to promote long-term usage for maintenance therapy for the disease entities listed above, as well as for other potential nongastrointestinal conditions.
Svoboda
R Paul
RP
Division of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Patel
Dhaval H
DH
Olden
Kevin W
KW
D000284:Administration, Oral; D019819:Budesonide / Q000008:administration & dosage* / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000737:chemistry; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000737:chemistry; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000503:physiopathology; D015394:Molecular Structure
D003692:Delayed-Action Preparations; D005938:Glucocorticoids; D019819:Budesonide