title: Direct comparison of the short-term clinical performance of Z Guidant and Taxus stents.
abstract: The recent introduction of drug-eluting stents in angioplasty of atherosclerotic blood vessels has significantly reduced the risks of in-stent restenosis (ISR) [1]. Indeed, it is known that in conventional stents ISR takes place in over 20% of the cases and up to 60% when implanted in diabetic patients. Conversely, clinical trials have shown that drug-eluting stents have significantly reduced ISR. Among the drug-eluting stents available on the market, Taxus stents (Tax, Boston Scientific, USA) are among the most used devices [2]. Tax are stainless-steel stents coated with Translute, a poly(styrene-b-isobutylene-b-styrene) polymer (PSIBS) eluting Placlitaxel, an anti-mitotic drug. Clinical trials on this type of drug-eluting stents have shown an incidence of restenosis of approximately 4%. The majority of these trials were randomized studies where conventional stents and drug-eluting devices have been implanted in separate patients' cohorts. Such a randomized design, although fundamental to collect statistically-relevant data, does not allow a direct histological comparison of different stent types when implanted in the same patient and do not show the individual susceptibility to the host response especially at short-term implantation times. Here, an interesting case study is presented where two chrome-cobalt stents (Z Guidant, ZG, Guidant Corp.) and a Tax have been simultaneously implanted in the same patient in three separate coronary arteries, retrieved after only 8 weeks and histologically analysed.
authors.forename: Anna
authors.initials: A
authors.lastname: Guildford
authors.forename: Paola
authors.initials: P
authors.lastname: Colombo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Bruschi
authors.forename: Edgardo
authors.initials: E
authors.lastname: Bonacina
authors.forename: Silvio
authors.initials: S
authors.lastname: Klugmann
authors.forename: Matteo
authors.initials: M
authors.lastname: Santin
mesh_terms: D017130:Angioplasty; D000972:Antineoplastic Agents, Phytogenic; D002858:Chromium Alloys; D003324:Coronary Artery Disease / Q000628:therapy*; D023903:Coronary Restenosis / Q000517:prevention & control*; D054855:Drug-Eluting Stents; D006801:Humans; D017239:Paclitaxel
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002858:Chromium Alloys; D017239:Paclitaxel