title: Gold nanorods as contrast agents for biological imaging: optical properties, surface conjugation and photothermal effects.
abstract: Gold nanorods (NRs) have plasmon-resonant absorption and scattering in the near-infrared (NIR) region, making them attractive probes for in vitro and in vivo imaging. In the cellular environment, NRs can provide scattering contrast for darkfield microscopy, or emit a strong two-photon luminescence due to plasmon-enhanced two-photon absorption. NRs have also been employed in biomedical imaging modalities such as optical coherence tomography or photoacoustic tomography. Careful control over surface chemistry enhances the capacity of NRs as biological imaging agents by enabling cell-specific targeting, and by increasing their dispersion stability and circulation lifetimes. NRs can also efficiently convert optical energy into heat, and inflict localized damage to tumor cells. Laser-induced heating of NRs can disrupt cell membrane integrity and homeostasis, resulting in Ca(2+) influx and the depolymerization of the intracellular actin network. The combination of plasmon-resonant optical properties, intense local photothermal effects and robust surface chemistry render gold NRs as promising theragnostic agents.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, IN, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Tong
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Wei
authors.forename: Alexander
authors.initials: A
authors.lastname: Wei
authors.forename: Ji-Xin
authors.initials: JX
authors.lastname: Cheng
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D015336:Molecular Probe Techniques; D043942:Nanotubes / Q000737:chemistry*; D055668:Photochemical Processes; D013499:Surface Properties
chemical_list: D003287:Contrast Media; D006046:Gold