title: A protein complex that regulates PtdIns(3,5)P2 levels.
abstract: Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) is needed for retrograde membrane trafficking from lysosomal and late endosomal compartments and its synthesis is tightly regulated. But how cells regulate PtdIns(3,5)P2 synthesis--for example, in response to hyperosmotic shock--remains unexplained. A paper from the Weisman group gives the most complete picture so far of a multiprotein complex that controls PtdIns(3,5)P2 synthesis and explains how a VAC14 mutation functionally impairs the scaffold protein at the heart of the complex and causes a neurodegenerative condition in mice.
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaton, Birmingham, UK. r.h.michell@bham.ac.uk
authors.forename: Robert H
authors.initials: RH
authors.lastname: Michell
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Dove
mesh_terms: D000818:Animals; D000071183:Autophagy-Related Proteins; D005420:Flavoproteins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009154:Mutation; D009997:Osmotic Pressure; D018129:Phosphatidylinositol Phosphates / Q000096:biosynthesis*; D010744:Phosphoric Monoester Hydrolases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D021381:Protein Transport; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
chemical_list: C441008:ATG18 protein, S cerevisiae; D000071183:Autophagy-Related Proteins; D005420:Flavoproteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D018129:Phosphatidylinositol Phosphates; D029701:Saccharomyces cerevisiae Proteins; C452436:VAC7 protein, S cerevisiae; C525133:Vac14 protein, mouse; C106336:phosphatidylinositol 3,5-diphosphate; C095504:FAB1 protein, S cerevisiae; D017853:Phosphotransferases (Alcohol Group Acceptor); C110669:FIG4 protein, S cerevisiae; D010744:Phosphoric Monoester Hydrolases