title: A preparatively convenient ligand-free catalytic PEG 2000 Suzuki-Miyaura coupling.
abstract: A ligand-free Suzuki-Miyaura reaction for the cross-coupling of aryl and heteroaryl bromides with aryl and heteroarylboronic acids has been developed utilizing catalytic polyethylene glycol 2000 (PEG 2000). This preparatively convenient system afforded the corresponding cross-coupled products in good to excellent isolated yields after a simple aqueous workup. Transmission electron microscopy (TEM) analysis of the Pd-PEG 2000 catalyst system revealed in situ-generated palladium nanoparticles after only 1 min of reaction.
authors.affiliation: Department of Process Research and Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, USA. thomas.razler@bms.com
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Razler
authors.forename: Yi
authors.initials: Y
authors.lastname: Hsiao
authors.forename: Feng
authors.initials: F
authors.lastname: Qian
authors.forename: Ruiling
authors.initials: R
authors.lastname: Fu
authors.forename: Rana Kashif
authors.initials: RK
authors.lastname: Khan
authors.forename: Wendel
authors.initials: W
authors.lastname: Doubleday
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D001969:Bromobenzenes / Q000737:chemistry*; D002384:Catalysis; D008024:Ligands; D010165:Palladium / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D001897:Boronic Acids; D001969:Bromobenzenes; D008024:Ligands; D011092:Polyethylene Glycols; D010165:Palladium; C010686:benzeneboronic acid