title: MF101, a selective estrogen receptor beta modulator for the treatment of menopausal hot flushes: a phase II clinical trial.
abstract: OBJECTIVE
  To determine the optimal dose, safety, and efficacy of an estrogen receptor beta selective Chinese herbal extract, menopausal formula 101 (MF101), for treating hot flushes.
  
  
  METHODS
  A randomized, blinded trial in 217 postmenopausal women with hot flushes randomized to 5 or 10 g/day of MF101 or placebo for 12 weeks.
  
  
  RESULTS
  The effects of 5 g/day of MF101 did not differ from those of placebo. After 12 weeks, the mean percent decrease in frequency of hot flushes in the 10 g/day group was 12.9% greater than that in the placebo group (P = 0.15), the median percent decrease was 11.7% greater than that in the placebo group (P = 0.05), and the proportion of women with at least a 50% reduction in hot flushes was 16.2% greater than that in the placebo group (P = 0.03).
  
  
  CONCLUSIONS
  Treatment with 10 g/day of MF101 reduces the frequency of hot flushes. Trials with higher doses are planned.
authors.affiliation: University of California, San Francisco, San Francisco, CA 94115, USA. Deborah.Grady@ucsf.edu
authors.forename: Deborah
authors.initials: D
authors.lastname: Grady
authors.forename: George F
authors.initials: GF
authors.lastname: Sawaya
authors.forename: Karen C
authors.initials: KC
authors.lastname: Johnson
authors.forename: William
authors.initials: W
authors.lastname: Koltun
authors.forename: Rachel
authors.initials: R
authors.lastname: Hess
authors.forename: Eric
authors.initials: E
authors.lastname: Vittinghoff
authors.forename: Margaret
authors.initials: M
authors.lastname: Kristof
authors.forename: Mary
authors.initials: M
authors.lastname: Tagliaferri
authors.forename: Isaac
authors.initials: I
authors.lastname: Cohen
authors.forename: Kristine E
authors.initials: KE
authors.lastname: Ensrud
mesh_terms: D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000187:drug effects / Q000473:pathology; D005260:Female; D019584:Hot Flashes / Q000188:drug therapy*; D006801:Humans; D008593:Menopause; D008796:Metrorrhagia / Q000139:chemically induced; D008875:Middle Aged; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: C517398:MF101 extract; D010936:Plant Extracts; D020845:Selective Estrogen Receptor Modulators