title: Effect of cardiac resynchronization therapy on mean platelet volume.
abstract: OBJECTIVE
  Cardiac resynchronization therapy (CRT) increases cardiac performance and decreases morbidity and mortality in patients with heart failure. Mean platelet volume (MPV), a marker of platelet hyperreactivity, was found to be increased in both chronic heart failure and thromboembolic events. Systemic and pulmonary thromboembolism is a frequent complication of heart failure.The aim of this study is to determine the effects of cardiac resynchronization therapy on MPV values.
  
  
  RESULTS
  Fifty-six heart failure patients with increased QRS duration underwent biventricular pacemaker implantation. Blood samples were collected the morning before implantation and at six months follow-up. Response criteria were: an increase in ejection fraction of more than 10% from baseline at six months or no hospitalization for major cardiac events during the first six months.The mean MPV values were decreased from 9.3 +/- 0.5 fl to 8.3 +/- 0.5 fl. Patients with recorded major cardiac events in the follow-up period had no statistically significant decrease in MPV values.
  
  
  CONCLUSIONS
  In our study we found that cardiac resynchronization therapy leads to a decreased MPV and clinical improvement in patients with heart failure that is accompanied with a decrease in MPV.
authors.affiliation: Dr. Siyami Ersek Cardiovascular and Thoracic Surgery Training and Research Hospital, Department of Cardiology, Istanbul, Turkey. 1-draalper@gmail.com
authors.forename: Ahmet Taha
authors.initials: AT
authors.lastname: Alper
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akyol
authors.forename: Hakan
authors.initials: H
authors.lastname: Hasdemir
authors.forename: Aydin
authors.initials: A
authors.lastname: Yildirim
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Nurkalem
authors.forename: Tolga Sinan
authors.initials: TS
authors.lastname: Güvenç
authors.forename: Nazmiye
authors.initials: N
authors.lastname: Cakmak
authors.forename: Enis
authors.initials: E
authors.lastname: Oğuz
authors.forename: Izzet Celal
authors.initials: IC
authors.lastname: Erdinler
authors.forename: Kadir
authors.initials: K
authors.lastname: Gürkan
mesh_terms: D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D009202:Cardiomyopathies / Q000503:physiopathology; D004562:Electrocardiography; D005260:Female; D006333:Heart Failure / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D011446:Prospective Studies