title: Magnolol enhances pentobarbital-induced sleeping behaviors: possible involvement of GABAergic systems.
abstract: This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABA(A) receptor alpha-subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of beta- or gamma-subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital-induced sleeping behaviors through the activation of GABAergic systems.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea.
authors.forename: Hong
authors.initials: H
authors.lastname: Ma
authors.forename: Chung-Soo
authors.initials: CS
authors.lastname: Kim
authors.forename: Yuan
authors.initials: Y
authors.lastname: Ma
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Nam
authors.forename: Dong-Seon
authors.initials: DS
authors.lastname: Kim
authors.forename: Sung-Sick
authors.initials: SS
authors.lastname: Woo
authors.forename: Jin-Tae
authors.initials: JT
authors.lastname: Hong
authors.forename: Ki-Wan
authors.initials: KW
authors.lastname: Oh
mesh_terms: D000818:Animals; D001713:Biphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology; D002712:Chlorides / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism; D012890:Sleep / Q000187:drug effects*
chemical_list: D001713:Biphenyl Compounds; D002712:Chlorides; D017705:Lignans; D011963:Receptors, GABA-A; C005498:magnolol; D005968:Glutamate Decarboxylase; D010424:Pentobarbital