In vivo anti-malarial effect of the beta-amino alcohol 1t on Plasmodium berghei.
Glycerol derivatives are a class of compounds, which are easy and inexpensive to produce with potent anti-malarial activities against blood stages of Plasmodium falciparum in vitro. In the present study, one of these compounds, termed 1t, which had the lowest IC(50) values, was assessed in a murine malarial model. Nuclear magnetic resonance imaging and Balb/c mice infected with Plasmodium berghei ANKA strain were treated in a 4-day suppressive test. Mice received a once-daily intraperitoneal administration of 50 mg/Kg of the drug for 4 days. Although no parasitaemia clearance was reached, a slower parasite proliferation and a slightly longer survival time compared with the placebo group were observed.
Bahamontes-Rosa
N
N
Department of Parasitology, Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
Bucher
K
K
Held
J
J
Robin
A
A
Hoffmann
W H
WH
Flitsch
S L
SL
Kremsner
P G
PG
Kun
J F J
JF
D000605:Amino Alcohols / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D020128:Inhibitory Concentration 50; D007274:Injections, Intraperitoneal; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018512:Parasitemia / Q000188:drug therapy; D010962:Plasmodium berghei / Q000187:drug effects*; D016019:Survival Analysis
D000605:Amino Alcohols; D000962:Antimalarials