title: A-94964, novel inhibitor of bacterial translocase I, produced by Streptomyces sp. SANK 60404. II. Physico-chemical properties and structure elucidation.
abstract: In our screening for translocase I inhibitors, we found the novel nucleoside antibiotic, A-94964 in the culture broth of Streptomyces sp. SANK 60404. The structure of A-94964 was elucidated primarily by various NMR studies, including a 1H-31P HMBC experiment. A-94964 has a unique structure which possesses a nucleoside moiety and an N-acylglucosamine moiety connected via a phosphate.
authors.affiliation: Exploratory Research Laboratories I, Daiichi-Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. fujita.yoko.x8@daiichisankyo.co.jp
authors.forename: Yoko
authors.initials: Y
authors.lastname: Fujita
authors.forename: Ryo
authors.initials: R
authors.lastname: Murakami
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Muramatsu
authors.forename: Shunichi
authors.initials: S
authors.lastname: Miyakoshi
authors.forename: Toshio
authors.initials: T
authors.lastname: Takatsu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001419:Bacteria / Q000201:enzymology*; D004187:Disaccharides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D011742:Pyrimidine Nucleotides / Q000737:chemistry*; D013302:Streptomyces / Q000378:metabolism*; D017855:Transferases (Other Substituted Phosphate Groups) / Q000037:antagonists & inhibitors*
chemical_list: C535078:A 94964; D000900:Anti-Bacterial Agents; D004187:Disaccharides; D011742:Pyrimidine Nucleotides; D017855:Transferases (Other Substituted Phosphate Groups); C100130:phospho-N-acetylmuramoyl pentapeptide transferase