title: Pertussis vaccine: a critique.
abstract: A critical level of serum IgG pertussis toxin antibody is both essential and sufficient to confer individual and herd immunity to pertussis. Monocomponent pertussis toxoid conferred such immunity in Sweden and in Denmark. We refute the notion that filamentous hemagglutinin, pertactin, and fimbriae add to the immunity conferred by pertussis toxoid and describe the artifact created when efficacy is estimated for multicomponent pertussis vaccines. Lastly, the genetically-inactivated mutant pertussis toxoid is safer, more immunogenic, and should be more effective than the current chemically-inactivated pertussis toxin.
authors.affiliation: Fogarty International Center, National Institute of Health, Bethesda, MD 20892-2423, USA. robbinsJo@mail.nih.gov
authors.forename: John B
authors.initials: JB
authors.lastname: Robbins
authors.forename: Rachel
authors.initials: R
authors.lastname: Schneerson
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Keith
authors.forename: Mark A
authors.initials: MA
authors.lastname: Miller
authors.forename: Joanna
authors.initials: J
authors.lastname: Kubler-Kielb
authors.forename: Birger
authors.initials: B
authors.lastname: Trollfors
mesh_terms: D018829:Adhesins, Bacterial / Q000276:immunology; D000328:Adult; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D006801:Humans; D032521:Immunity, Herd; D007074:Immunoglobulin G / Q000097:blood; D051379:Mice; D037342:Pertussis Toxin / Q000276:immunology; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000276:immunology*; D014121:Toxoids / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology; D010566:Virulence Factors, Bordetella / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control*
chemical_list: D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D007074:Immunoglobulin G; D010567:Pertussis Vaccine; D014121:Toxoids; D015164:Vaccines, Inactivated; D010566:Virulence Factors, Bordetella; C065273:filamentous hemagglutinin adhesin, Bordetella pertussis; C051093:pertussis toxoid; C068929:pertactin; D037342:Pertussis Toxin