[The characteristic of radioprotective properties of a radioprotectant B-190 at its administration after radiation].
In experiences on mice F1 (CBAxC57B 1/6) at a gamma-irradiation in a lethal dose LD(35-70/30) the radioprotectant B-190 at administration after an exposure would rise an animal survival--on 35-55%, caused the increase of the amount of endogenic colony in a spleen and of leucocytes in blood on 11th and 30th day of an acute radiation desease accordingly. The drug has the effect in the interval of doses from 75 up to 150 mg/kg b.w. with the rise of radioprotective action on dose reduction factor from 1.1 up to 1.22. alpha(1)-adrenoblockers terasosin in a dose of 15 mg/kg b.w. partially would reduce radioprotective properties of B-190 as radioprotectant or and drug of early therapy of acute radiation desease.
Vasin
M V
MV
Ushakov
I B
IB
Kovtun
V Iu
VIu
Komarova
S N
SN
Semenova
L A
LA
Koroleva
L V
LV
Galkin
A A
AA
Afanas'ev
R V
RV
D054508:Acute Radiation Syndrome / Q000188:drug therapy* / Q000276:immunology; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays; D007274:Injections, Intraperitoneal; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000276:immunology; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D013154:Spleen / Q000276:immunology
D011837:Radiation-Protective Agents