title: Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease.
abstract: OBJECTIVE
  The polymorphism (rs1800587) in the 5'-flanking regulatory region at -889 of the interleukin-1alpha gene has been shown to be associated with inflammatory diseases and Alzheimer's disease (AD). The aim of the current study is to determine whether there is an association between the promoter region polymorphism of the interleukin-1alpha gene and late-onset AD in a cohort of Turkish patients.
  
  
  METHODS
  One hundred and four subjects with dementia of the Alzheimer type and 103 age-matched controls were genotyped according to the PCR with confronting two-pair primers method.
  
  
  RESULTS
  Although the distribution of genotypes did not significantly differ (p = 0.107), the difference between allelic frequency was nearly significant according to a chi(2) test (p = 0.05) when the controls and patients were compared.
  
  
  CONCLUSIONS
  Our results showed that there is no association between the -889 C/T transition on the interleukin-1alpha gene and late-onset AD in the Turkish population.
authors.affiliation: Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: Erdinç
authors.initials: E
authors.lastname: Dursun
authors.forename: Duygu
authors.initials: D
authors.lastname: Gezen-Ak
authors.forename: Turan
authors.initials: T
authors.lastname: Ertan
authors.forename: Başar
authors.initials: B
authors.lastname: Bilgiç
authors.forename: Hakan
authors.initials: H
authors.lastname: Gürvit
authors.forename: Murat
authors.initials: M
authors.lastname: Emre
authors.forename: Engin
authors.initials: E
authors.lastname: Eker
authors.forename: Funda
authors.initials: F
authors.lastname: Engin
authors.forename: Omer
authors.initials: O
authors.lastname: Uysal
authors.forename: Selma
authors.initials: S
authors.lastname: Yilmazer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014421:Turkey / Q000453:epidemiology
chemical_list: D017931:DNA Primers; D053582:Interleukin-1alpha; D004247:DNA