title: A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery.
abstract: A novel temperature-sensitive liposomal MRI contrast agent has been developed, which allows drug carrier localization using (1)H CEST with simultaneous quantification of the drug release using (19)F MR imaging in response to a local temperature increase.
authors.affiliation: Philips Research Europe, High Tech Campus 11, 5656 AE Eindhoven, The Netherlands. sander.langereis@philips.com
authors.forename: Sander
authors.initials: S
authors.lastname: Langereis
authors.forename: Jochen
authors.initials: J
authors.lastname: Keupp
authors.forename: Juliën L J
authors.initials: JL
authors.lastname: van Velthoven
authors.forename: Inge H C
authors.initials: IH
authors.lastname: de Roos
authors.forename: Dirk
authors.initials: D
authors.lastname: Burdinski
authors.forename: Jeroen A
authors.initials: JA
authors.lastname: Pikkemaat
authors.forename: Holger
authors.initials: H
authors.lastname: Grüll
mesh_terms: D003287:Contrast Media / Q000032:analysis* / Q000737:chemistry*; D016503:Drug Delivery Systems; D005461:Fluorine / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D011522:Protons; D012680:Sensitivity and Specificity; D013053:Spectrophotometry; D013696:Temperature
chemical_list: D003287:Contrast Media; D008081:Liposomes; D011522:Protons; D005461:Fluorine