title: [Sneddon-Wilkinson's subcorneal dermatosis: an atypical case pustular].
abstract: BACKGROUND
  Sneddon-Wilkinson disease (SW) is chronic and benign disease belonging to the heterogeneous spectrum of neutrophilic diseases. It is characterised by flask, superficial, aseptic pustules, mainly involving the trunk, axilla and inguinal folds, favourably responsive to sulfones.
  
  
  OBJECTIVE
  We report an original case with an atypical clinical presentation and course.
  
  
  METHODS
  A 25-year old woman presented with an erythematous pustular eruption that had appeared one week before. Similar flare-ups were reported for 3 years. No drug intake history nor recent infection were reported. Physical examination showed superficial pustules mainly located on the face and limbs, lying on an erythematous skin and sometimes grouped in large plaques with a serpiginous disposition having a characteristic aspect of hypopyon pustule. A specimen taken from the pustules did not show bacterial or fungal infection. Histological examination of a biopsy specimen showed subcorneal pustules with a dermal peri-capillary neutrophilic infiltrate. Direct immuno-fluorescence was negative. No associated diseases were found. The patient was resistant to a 1 month treatment with dapsone (100 mg/day). Improvement was obtained with acitretin (25 mg/day) within 3 months.
  
  
  CONCLUSIONS
  Our case has some specificities: cephalic involvement, resistance to dapsone and favourable outcome to a low dose of acitretin.
authors.affiliation: Service de Dermatologie, Hôpital Habib Thameur, Tunis, Tunisie.
authors.forename: Amel
authors.initials: A
authors.lastname: Souissi
authors.forename: Samy
authors.initials: S
authors.lastname: Fenniche
authors.forename: Rym
authors.initials: R
authors.lastname: Benmously
authors.forename: Hayet
authors.initials: H
authors.lastname: Marrak
authors.forename: Olfa
authors.initials: O
authors.lastname: Khayat
authors.forename: Achraf
authors.initials: A
authors.lastname: Debbiche
authors.forename: Mohamed
authors.initials: M
authors.lastname: Ben Ayed
authors.forename: I
authors.initials: I
authors.lastname: Mokhtar
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005121:Extremities; D005145:Face; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D007641:Keratolytic Agents; D003622:Dapsone; D017255:Acitretin