title: Effects of the polysaccharide beta-glucan on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in mice.
abstract: Alterations that could lead to the cancer development may also be related to an adverse development of offspring in experimental animals. Some functional foods, which contain the polysaccharide beta-glucan, have been described as being effective in the prevention of clastogenic damage. Based on that finding, the aim of the present study was to determine the efficacy of this sugar polymer in the mutagenic and teratogenic damage control. Two sets of females, pregnant and non-pregnant, were evaluated. The results indicated that beta-glucan was effective in preventing clastogenic damage in pregnant as well as non-pregnant females. In addition, pregnant females were more susceptible to mutagenic damage. However, teratogenic effects were not prevented effectively, although there was a trend toward a reduction in level of malformations. Despite beta-glucan did not prevent malformations, it increased fetal viability and reduced number of post-implantation losses and resorption, thereby enhancing reproductive performance in females.
authors.affiliation: Department of Biology, Center of Biological Sciences, Londrina State University, Londrina, PR, Brazil.
authors.forename: Rodrigo Juliano
authors.initials: RJ
authors.lastname: Oliveira
authors.forename: Maria José Sparça
authors.initials: MJ
authors.lastname: Salles
authors.forename: Ariane Fernanda
authors.initials: AF
authors.lastname: da Silva
authors.forename: Tatiane Yumi Nakamura
authors.initials: TY
authors.lastname: Kanno
authors.forename: Ana Carolina Dos Santos
authors.initials: AC
authors.lastname: Lourenço
authors.forename: Gabriele Antico
authors.initials: GA
authors.lastname: Freiria
authors.forename: Hevenilton José
authors.initials: HJ
authors.lastname: Matiazi
authors.forename: Lúcia Regina
authors.initials: LR
authors.lastname: Ribeiro
authors.forename: Mário Sérgio
authors.initials: MS
authors.lastname: Mantovani
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D000818:Animals; D016587:Antimutagenic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000633:toxicity*; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005865:Gestational Age; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced* / Q000187:drug effects / Q000196:embryology; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000235:genetics / Q000517:prevention & control; D047071:beta-Glucans / Q000627:therapeutic use*
chemical_list: D016587:Antimutagenic Agents; D047071:beta-Glucans; D003520:Cyclophosphamide