Intermolecular antiselective and enantioselective reductive coupling of enones and aromatic aldehydes with chiral Rh(Phebox) catalysts.
The intermolecular reductive coupling reaction of cyclopent-2-enone and aromatic aldehydes was realized by chiral rhodium-(bisoxazolinyl)phenyl catalysts, Rh(Phebox-Ph)(OAc)(2)(H(2)O), with diphenymethylsilane as a hydride donor to give the corresponding beta-hydroxyketones in high anti-selectivity (up to 96%) with high enantioselectivity (up to 93%).
Shiomi
Takushi
T
Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Chikusa, Nagoya 464-8603, Japan.
Adachi
Takahiro
T
Ito
Jun-ichi
J
Nishiyama
Hisao
H