Old nuclei spring new leaks.
The nuclear pore complex (NPC) regulates the bidirectional movement of cell components across the nuclear envelope. In this issue, D'Angelo et al. (2009) demonstrate that the NPC loses essential protein subunits as cells age, resulting in increased nuclear permeability and potentially contributing to organismal aging.
Kotwaliwale
Chitra V
CV
Howard Hughes Medical Institute, Berkeley, CA 94720, USA. chitra.kot@gmail.com
Dernburg
Abby F
AF
D000375:Aging; D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D006801:Humans; D022022:Nuclear Pore / Q000502:physiology*