title: [Clinical investigation of the Heidelberg retina tomograph II in assessment of macular edema].
abstract: OBJECTIVE
  To evaluate the significance of detecting macular edema by the Retina Module of the Heidelberg retina tomograph II (HRTII).
  
  
  METHODS
  Comparative clinical study, One hundred and twenty-six eyes were divided into two groups according to FFA results, one with macular edema and the other without macular edema. Morphological changes in macular edema were observed by HRTII and e (edema index) in two areas of each eye were determined. E value in these two groups and the correlation of e with retinal thickness, BCVA, amplitude and latency of N1 and P1 by multifocal electroretinogram were analyzed.
  
  
  RESULTS
  HRTII-RM scan could distinguish different kinds of macular edema (cystoid, local and diffused) and the difference of e between these two groups was significant (e1: t = -19.238, e2: t = -12.436; P < 0.01). The best critical value of e was 1.475 and 1.411 (e1 = 1.475, e2 = 1.411). The sensitivity of e was 92.9% and 91.8% (e1 = 92.9%, e2 = 91.8%). The specificity of e was 97.6% and 95.1% (e1 = 97.6%, e2 = 95.1%). The correlation coefficient between e and retinal thickness was 0.816 and 0.587 (e1: r = 0.816, e2: r = 0.587; P < 0.01); was -0.658 and -0.640 (e1: r = -0.658, e2: r = -0.640; P < 0.01) between e and BCVA; was 0.266 and 0.312 (e1: r = 0.266, e2: r = 0.312; P < 0.01) between e and latency of N1; was -0.609 and -0.586 (e1: r = -0.609, e2: r = -0.586; P < 0.01) between e and amplitude of N1; was 0.529 and 0.431 (e1: r = 0.529, e2: r = 0.431; P < 0.01) between e and latency of P1 and was -0.783 and -0.714 (e1: r = -0.783, e2: r = -0.714; P < 0.01) between e and amplitude of P1, respectively.
  
  
  CONCLUSIONS
  There are characteristic changes in the appearance of macular edema as examined by HRT II-RM. The quantitative index e value also shows remarkable changes. HRT II-RM not only detects morphological changes, but also relates to functional changes. This method is capable for evaluating the macular edema.
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital University of Medical Sciences, Beijing 100730, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhou
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Bei
authors.initials: B
authors.lastname: Tian
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D003930:Diabetic Retinopathy / Q000000981:diagnostic imaging; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008269:Macular Edema / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012160:Retina / Q000000981:diagnostic imaging*; D014054:Tomography / Q000379:methods*; D041623:Tomography, Optical Coherence