title: Nanoparticles of adaptive supramolecular networks self-assembled from nucleotides and lanthanide ions.
abstract: Amorphous nanoparticles of supramolecular coordination polymer networks are spontaneously self-assembled from nucleotides and lanthanide ions in water. They show intrinsic functions such as energy transfer from nucleobase to lanthanide ions and excellent performance as contrast enhancing agents for magnetic resonance imaging (MRI). Furthermore, adaptive inclusion properties are observed in the self-assembly process: functional materials such as fluorescent dyes, metal nanoparticles, and proteins are facilely encapsulated. Dyes in these nanoparticles fluoresce in high quantum yields with a single exponential decay, indicating that guest molecules are monomerically wrapped in the network. Gold nanoparticles and ferritin were also wrapped by the supramolecular shells. In addition, these nucleotide/lanthanide nanoparticles also serve as scaffolds for immobilizing enzymes. The adaptive nature of present supramolecular nanoparticles provides a versatile platform that can be utilized in a variety of applications ranging from material to biomedical sciences. As examples, biocompatibility and liver-directing characteristics in in vivo tissue localization experiments are demonstrated.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka Nishi-ku, Fukuoka 819-0395, Japan.
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Nishiyabu
authors.forename: Nozomi
authors.initials: N
authors.lastname: Hashimoto
authors.forename: Ten
authors.initials: T
authors.lastname: Cho
authors.forename: Kazuto
authors.initials: K
authors.lastname: Watanabe
authors.forename: Takefumi
authors.initials: T
authors.lastname: Yasunaga
authors.forename: Ayataka
authors.initials: A
authors.lastname: Endo
authors.forename: Kenji
authors.initials: K
authors.lastname: Kaneko
authors.forename: Takuro
authors.initials: T
authors.lastname: Niidome
authors.forename: Masaharu
authors.initials: M
authors.lastname: Murata
authors.forename: Chihaya
authors.initials: C
authors.lastname: Adachi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Katayama
authors.forename: Makoto
authors.initials: M
authors.lastname: Hashizume
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kimizuka
mesh_terms: D000249:Adenosine Monophosphate / Q000737:chemistry; D004800:Enzymes, Immobilized / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D005682:Gadolinium / Q000737:chemistry; D019786:Gadolinium DTPA / Q000737:chemistry; D006367:HeLa Cells; D006735:Horseradish Peroxidase / Q000737:chemistry; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D004800:Enzymes, Immobilized; D028581:Lanthanoid Series Elements; D009711:Nucleotides; D014867:Water; D000249:Adenosine Monophosphate; D005682:Gadolinium; D006735:Horseradish Peroxidase; D019786:Gadolinium DTPA; C038958:gadolinium chloride