A convenient synthesis of (S)-H4-BINOL and its derivatives via hydrogenation of monoesters of BINOL.
A new multigram synthesis of chiral (S)-H(4)-BINOL and its derivatives in moderate to high yield (up to 83% total yield) via monoesterification of (S)-BINOL, hydrogenation, and saponification reaction was described. The two new monomethylated (S)-H(4)-BINOL obtained may be useful materials in asymmetric catalysis.
Li
Xinsheng
X
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Zhejiang Normal University, Jinhua 321004, China. sky33@zjnu.cn
Ding
Qianchang
Q
Ge
Jianfeng
J
Xie
Jianwu
J
Xu
Dongcheng
D