Transition metal catalysed reactions of alcohols using borrowing hydrogen methodology.
The reactivity of alcohols can be enhanced by the temporary removal of hydrogen using a transition metal catalyst to generate an intermediate aldehyde or ketone. The so-formed carbonyl compound has a greater reactivity towards nucleophilic addition accommodating the in situ formation of imines or alkenes. The return of hydrogen from the catalyst leads to the formation of new C-N and C-C bonds, often with water as the only reaction by-product.
Nixon
Tracy D
TD
Department of Chemistry, University of Bath, Claverton Down, Bath, UKBA2 7AY.
Whittlesey
Michael K
MK
Williams
Jonathan M J
JM
D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry; D028561:Transition Elements / Q000737:chemistry*
D000438:Alcohols; D000447:Aldehydes; D007659:Ketones; D028561:Transition Elements; D006859:Hydrogen