Constraints to progress in embryonic stem cells from domestic species.
Domestic animal embryonic stem cells are of potentially big value in transgenic research and studies of lineage commitment and development. Unfortunately, despite many efforts, validated embryonic stem cell lines in species other than mice and primates are yet to be isolated. Here we review some factors that might help to explain why derivation of domestic animal embryonic stem cells is still unsuccessful.
Muñoz
M
M
Area de Genética y Reproducción, SERIDA, Asturias, Spain. mmunoz@serida.org
Trigal
B
B
Molina
I
I
Díez
C
C
Caamaño
J N
JN
Gómez
E
E
D000818:Animals; D000829:Animals, Domestic; D001755:Blastocyst / Q000166:cytology; D002417:Cattle; D053595:Embryonic Stem Cells / Q000166:cytology*; D006801:Humans; D051379:Mice; D008954:Models, Biological; D013045:Species Specificity; D013552:Swine; D014158:Transcription, Genetic