Nanoparticles of adaptive supramolecular networks self-assembled from nucleotides and lanthanide ions.
Amorphous nanoparticles of supramolecular coordination polymer networks are spontaneously self-assembled from nucleotides and lanthanide ions in water. They show intrinsic functions such as energy transfer from nucleobase to lanthanide ions and excellent performance as contrast enhancing agents for magnetic resonance imaging (MRI). Furthermore, adaptive inclusion properties are observed in the self-assembly process: functional materials such as fluorescent dyes, metal nanoparticles, and proteins are facilely encapsulated. Dyes in these nanoparticles fluoresce in high quantum yields with a single exponential decay, indicating that guest molecules are monomerically wrapped in the network. Gold nanoparticles and ferritin were also wrapped by the supramolecular shells. In addition, these nucleotide/lanthanide nanoparticles also serve as scaffolds for immobilizing enzymes. The adaptive nature of present supramolecular nanoparticles provides a versatile platform that can be utilized in a variety of applications ranging from material to biomedical sciences. As examples, biocompatibility and liver-directing characteristics in in vivo tissue localization experiments are demonstrated.
Nishiyabu
Ryuhei
R
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka Nishi-ku, Fukuoka 819-0395, Japan.
Hashimoto
Nozomi
N
Cho
Ten
T
Watanabe
Kazuto
K
Yasunaga
Takefumi
T
Endo
Ayataka
A
Kaneko
Kenji
K
Niidome
Takuro
T
Murata
Masaharu
M
Adachi
Chihaya
C
Katayama
Yoshiki
Y
Hashizume
Makoto
M
Kimizuka
Nobuo
N
D000249:Adenosine Monophosphate / Q000737:chemistry; D004800:Enzymes, Immobilized / Q000737:chemistry; D031541:Fluorescence Resonance Energy Transfer; D005682:Gadolinium / Q000737:chemistry; D019786:Gadolinium DTPA / Q000737:chemistry; D006367:HeLa Cells; D006735:Horseradish Peroxidase / Q000737:chemistry; D006801:Humans; D028581:Lanthanoid Series Elements / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D053758:Nanoparticles / Q000737:chemistry*; D009711:Nucleotides / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D004800:Enzymes, Immobilized; D028581:Lanthanoid Series Elements; D009711:Nucleotides; D014867:Water; D000249:Adenosine Monophosphate; D005682:Gadolinium; D006735:Horseradish Peroxidase; D019786:Gadolinium DTPA; C038958:gadolinium chloride