title: A general method for the synthesis of unsymmetrically substituted ureas via palladium-catalyzed amidation.
abstract: A general and practical method for the preparation of unsymmetrically substituted ureas has been developed utilizing palladium-catalyzed amidation. Both aryl bromides and chlorides, as well as heteroaryl chlorides, have been coupled to aryl, benzyl, and aliphatic ureas by using a novel nonproprietary bipyrazole ligand (bippyphos).
authors.affiliation: Abbott Laboratories, GPRD Process Research and Development, Dept. R450, Bldg. R8, 1401 Sheridan Road, North Chicago, Illinois 60064, USA. brian.kotecki@abbott.com
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Kotecki
authors.forename: Dilinie P
authors.initials: DP
authors.lastname: Fernando
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Haight
authors.forename: Kirill A
authors.initials: KA
authors.lastname: Lukin
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010165:Palladium; D014508:Urea