title: The effect of scaffold architecture on properties of direct 3D fiber deposition of porous Ti6Al4V for orthopedic implants.
abstract: 3D porous Ti6Al4V scaffolds were directly fabricated by a rapid prototyping technology, 3D fiber deposition (3DF). In this study, scaffolds with different structures were fabricated by changing fiber spacing and fiber orientation. The influence of different architectures on mechanical properties and permeability of the scaffold were investigated. Mechanical analysis revealed that compressive strength and E-modulus increase with decreasing the porosity. Permeability measurements showed that not only the total porosity but also the porous structure can influence the permeability. 3DF was found to provide good control and reproducibility of the desired degree of porosity and the 3D structure. Results of this study demonstrate that the 3DF of Ti6Al4V give us flexibility and versatility to fabricate and improve scaffolds to better mimic the architecture and properties of natural bone and meet the requirements of bone graft substitutes and orthopedic and dental implants.
authors.affiliation: Institute for Biomedical Technology, University of Twente, 7500 AE, Enschede, The Netherlands. pingzi@excite.com
authors.forename: J P
authors.initials: JP
authors.lastname: Li
authors.forename: J R
authors.initials: JR
authors.lastname: de Wijn
authors.forename: C A
authors.initials: CA
authors.lastname: van Blitterswijk
authors.forename: K
authors.initials: K
authors.lastname: de Groot
mesh_terms: D000077:Acetabulum; D000497:Alloys; D018786:Bone Substitutes / Q000737:chemistry*; D019245:Compressive Strength; D055119:Elastic Modulus; D010539:Permeability; D016062:Porosity; D019736:Prostheses and Implants; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D000497:Alloys; D018786:Bone Substitutes; C031462:titanium alloy (TiAl6V4); D014025:Titanium