title: Cytotoxic guanidine alkaloids from Pterogyne nitens.
abstract: As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.
authors.affiliation: Institute of Chemistry, Nucley of Bioassay, Biosynthesis and Ecophysiology of Natural Products, NuBBE, Sao Paulo State University, UNESP, Araraquara, SP, Brazil.
authors.forename: Luis Octávio
authors.initials: LO
authors.lastname: Regasini
authors.forename: Ian
authors.initials: I
authors.lastname: Castro-Gamboa
authors.forename: Dulce Helena Siqueira
authors.initials: DH
authors.lastname: Silva
authors.forename: Maysa
authors.initials: M
authors.lastname: Furlan
authors.forename: Eliezer Jesus
authors.initials: EJ
authors.lastname: Barreiro
authors.forename: Paulo Michel Pinheiro
authors.initials: PM
authors.lastname: Ferreira
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Letícia Veras Costa
authors.initials: LV
authors.lastname: Lotufo
authors.forename: Manoel Odorico
authors.initials: MO
authors.lastname: de Moraes
authors.forename: Maria Claudia Marx
authors.initials: MC
authors.lastname: Young
authors.forename: Vanderlan da Silva
authors.initials: Vda S
authors.lastname: Bolzani
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D007887:Fabaceae / Q000737:chemistry*; D006146:Guanidines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006146:Guanidines; C548768:nitensidine D; C548769:nitensidine E