title: Microsubthalamotomy effect at day 3: screening for determinants.
abstract: A microsubthalamotomy (mSTN) effect has been frequently reported after implantation that improves Parkinson's motor disability. It is usually believed that mSTN effect reflects the post-traumatic tissue reaction within the STN. However, it has never, to our knowledge, been reported whether pre and intraoperative factors could predict this mSTN effect. Preoperative clinical characteristics, that is, age, disease duration, Mattis Dementia Rating Scale score, levodopa responsiveness, severity of motor fluctuations and dyskinesia, and intraoperative parameters, that is, the number of tracks, distance of typical STN neuronal activity recorded along all microelectrodes, and along the definitive electrodes, were assessed in 40 consecutive PD patients submitted for STN stimulation. Multiple stepwise regression analysis showed that only the number of tracks used for microelectrodes recordings was predictor of the contralateral mSTN effect (F (4,73) = 1.83, P = 0.02). This result suggests that the contralateral mSTN depends on the tissue changes along the entirety of surgical trajectories affecting both STN and its adjacent structures.
authors.affiliation: Department of Neurology, Rouen University Hospital, Rouen, France. david.maltete@chu-rouen.fr
authors.forename: David
authors.initials: D
authors.lastname: Maltête
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chastan
authors.forename: Stéphane
authors.initials: S
authors.lastname: Derrey
authors.forename: Bertrand
authors.initials: B
authors.lastname: Debono
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gérardin
authors.forename: Romain
authors.initials: R
authors.lastname: Lefaucheur
authors.forename: Bruno
authors.initials: B
authors.lastname: Mihout
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000978:Antiparkinson Agents / Q000627:therapeutic use; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery; D003131:Combined Modality Therapy; D003287:Contrast Media; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000379:methods*; D020820:Dyskinesias / Q000209:etiology; D005260:Female; D006801:Humans; D018476:Hypokinesia / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009127:Muscle Rigidity / Q000209:etiology; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D011184:Postoperative Period; D015641:Radiography, Interventional; D012720:Severity of Illness Index; D013238:Stereotaxic Techniques; D013788:Thalamus / Q000601:surgery*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014202:Tremor / Q000209:etiology
chemical_list: D000978:Antiparkinson Agents; D003287:Contrast Media