Cortical PIB binding in Lewy body disease is associated with Alzheimer-like characteristics.
About one fourth of Lewy body disease (LBD) patients show cortical beta-amyloid load, basically a hallmark of Alzheimer disease (AD). Using [11C]PIB-PET, we tested whether LBD patients with beta-amyloid burden differ from those without with respect to demographic, clinical, biochemical and genetic parameters. Thirty-five LBD subjects (9 patients with Lewy body dementia, DLB; 12 demented Parkinson patients, PDD; 14 non-demented PD, PDND) underwent [11C]PIB-PET, and were classified as either PIB(+) or PIB(-) according to cortical PIB uptake. PIB+ and PIB(-) patients were then compared according to demographic, clinical, biochemical and genetic parameters. None of the PDND, but four PDD and four DLB subjects were PIB+. In PIB+ subjects, ApoE4 prevalence was higher, CSF Abeta42 levels were lower and, among demented patients, PIB-binding was associated with a lower MMSE score. Motor symptoms were not associated with PIB binding. Thus, LBD patients with cortical beta-amyloid show characteristics usually observed in AD.
Maetzler
Walter
W
Center of Neurology, Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany.
Liepelt
Inga
I
Reimold
Matthias
M
Reischl
Gerald
G
Solbach
Christoph
C
Becker
Clemens
C
Schulte
Claudia
C
Leyhe
Thomas
T
Keller
Stefanie
S
Melms
Arthur
A
Gasser
Thomas
T
Berg
Daniela
D
D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism*; D053327:Apolipoprotein E4 / Q000378:metabolism; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D049268:Positron-Emission Tomography; D012044:Regression Analysis; D017422:Sequence Analysis, DNA; D013844:Thiazoles / Q000378:metabolism*
C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D016229:Amyloid beta-Peptides; D000814:Aniline Compounds; D053327:Apolipoprotein E4; D002250:Carbon Radioisotopes; D010446:Peptide Fragments; D013844:Thiazoles; C075222:amyloid beta-protein (1-42)