T-cell activation by dendritic cells in the lymph node: lessons from the movies.
Interactions between T cells and dendritic cells (DCs) in the lymph nodes are crucial for initiating cell-mediated adaptive immune responses. With the help of two-photon imaging, the complexity of these cellular contacts in vivo has recently been captured in time-lapse movies in several immunological contexts. Well beyond the satisfaction of seeing a T-cell response as it happens, these experiments provide fundamental insights into the regulation and the biological meaning of T-cell-DC contact dynamics. This Review focuses on how this emerging field is changing our perception of T-cell activation by DCs.
Bousso
Philippe
P
G5 Dynamiques des Réponses Immunea, Equipe Avenir, Inserm U668, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris 15, France. bousso@pasteur.fr
D000818:Animals; D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology*