Effects of the polysaccharide beta-glucan on clastogenicity and teratogenicity caused by acute exposure to cyclophosphamide in mice.
Alterations that could lead to the cancer development may also be related to an adverse development of offspring in experimental animals. Some functional foods, which contain the polysaccharide beta-glucan, have been described as being effective in the prevention of clastogenic damage. Based on that finding, the aim of the present study was to determine the efficacy of this sugar polymer in the mutagenic and teratogenic damage control. Two sets of females, pregnant and non-pregnant, were evaluated. The results indicated that beta-glucan was effective in preventing clastogenic damage in pregnant as well as non-pregnant females. In addition, pregnant females were more susceptible to mutagenic damage. However, teratogenic effects were not prevented effectively, although there was a trend toward a reduction in level of malformations. Despite beta-glucan did not prevent malformations, it increased fetal viability and reduced number of post-implantation losses and resorption, thereby enhancing reproductive performance in females.
Oliveira
Rodrigo Juliano
RJ
Department of Biology, Center of Biological Sciences, Londrina State University, Londrina, PR, Brazil.
Salles
Maria José Sparça
MJ
da Silva
Ariane Fernanda
AF
Kanno
Tatiane Yumi Nakamura
TY
Lourenço
Ana Carolina Dos Santos
AC
Freiria
Gabriele Antico
GA
Matiazi
Hevenilton José
HJ
Ribeiro
Lúcia Regina
LR
Mantovani
Mário Sérgio
MS
D000014:Abnormalities, Drug-Induced / Q000196:embryology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*; D000818:Animals; D016587:Antimutagenic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000633:toxicity*; D005260:Female; D047109:Fetal Development / Q000187:drug effects; D005865:Gestational Age; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced* / Q000187:drug effects / Q000196:embryology; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000235:genetics / Q000517:prevention & control; D047071:beta-Glucans / Q000627:therapeutic use*
D016587:Antimutagenic Agents; D047071:beta-Glucans; D003520:Cyclophosphamide