[Cox proportional hazard model analysis of prognosis in patients with carcinoma of esophagus and gastric cardia after radical resection].
OBJECTIVE
To investigate the factors affecting the long-term survival of patients with carcinoma of esophagus and gastric cardia after curative resection.


METHODS
The clinical data of 906 patients with carcinoma of esophagus and gastric cardia treated by radical resection in 1996 - 2004 were analyzed retrospectively. Twelve clinicopathological factors possibly influencing survival were encoded and assessed by Cox regression analysis.


RESULTS
The 1-, 3- and 5-year cumulative survival rates were 89.8%, 75.4% and 71.7%, respectively. The univariate analysis showed that age, length of tumor, pathological differentiation, number of metastatic lymph nodes, depth of invasion, involvement of adjacent organs and the TNM stage influenced the prognosis significantly (P < 0.01). However, multivariate analysis showed that pathologic differentiation, number of metastatic lymph nodes, involvement of adjacent organs and TNM stage were independent prognostic factors (P < 0.05).


CONCLUSIONS
The independent prognostic factors of the patients with carcinoma of esophagus and gastric cardia are pathologic differentiation, TNM stage, number of metastatic lymph nodes, and involvement of adjacent organs. The other factors influencing survival are age, length of tumor and depth of invasion. Furthermore, invasion of adjacent organs suggests worse prognosis, and should be followed-up closely.
Liu
Wei
W
Department of Medical Oncology, the Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China.
Hao
Xi-Shan
XS
Fan
Qian
Q
Li
Hai-Xin
HX
Song
Li-Nan
LN
Wang
Shi-Jie
SJ
Wang
Pei-Zhong
PZ
Jin
Ying
Y
Chen
Yong
Y
Guan
Li-Yun
LY
Ping
Yu-Min
YM
Meng
Xian-Li
XL
Wang
Rui
R
Liu
Jun-Feng
JF
Wang
Xiao-Ling
XL
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery; D018288:Carcinoma, Small Cell / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002299:Cardia; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000601:surgery; D016629:Esophagectomy / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate