title: Successful ABO-incompatible heart transplantation in a child despite blood-group sensitization after ventricular assist device support.
abstract: In the first two yr of life blood-group incompatible (ABO-incompatible) heart transplantation can be performed leading to immune tolerance to donor blood group. Antibody titers should be below 1:4. VAD use is correlated with sensitization toward blood-group antigens. A boy was diagnosed with dilated cardiomyopathy at nine months of age and listed for 0-compatible transplantation. Progressive heart failure required implantation of a left VAD. His listing was extended for ABO-incompatible transplantation despite antibody titers of 1:32 anti-A and 1:8 anti-B. After 26 days on VAD, he was transplanted with a B donor heart. No hyperacute or acute rejection occurred in 12 months post-transplant. Anti-B antibodies rose to a maximum of 1:2. No use of rituximab or plasmapheresis was required. There are no signs of graft vasculopathy. This indicates that inclusion criteria for ABO-incompatible transplantation may be extended to immediate cases. This is the first case with a healthy immune system to show signs of tolerance development after ABO-incompatible heart transplantation with increased prior antibody titers and without specific treatment.
authors.affiliation: Pediatric Cardiology and Intensive Care, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany. simon.urschel@med.uni-muenchen.de
authors.forename: S
authors.initials: S
authors.lastname: Urschel
authors.forename: R
authors.initials: R
authors.lastname: Dalla Pozza
authors.forename: M
authors.initials: M
authors.lastname: Loeff
authors.forename: C
authors.initials: C
authors.lastname: Schmitz
authors.forename: R
authors.initials: R
authors.lastname: Sodian
authors.forename: M
authors.initials: M
authors.lastname: Schmoeckel
authors.forename: C
authors.initials: C
authors.lastname: Kowalski
authors.forename: H
authors.initials: H
authors.lastname: Netz
mesh_terms: D000017:ABO Blood-Group System / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000276:immunology; D006084:Graft Rejection; D006333:Heart Failure / Q000628:therapy; D016027:Heart Transplantation / Q000379:methods*; D006353:Heart-Assist Devices; D006801:Humans; D007107:Immune System; D007223:Infant; D008297:Male; D013997:Time Factors; D023001:Transplantation Tolerance; D016896:Treatment Outcome
chemical_list: D000017:ABO Blood-Group System