[Effect of fenghuaqianqingcha on experimentally induced prostatic hyperplasia in mice].
OBJECTIVE
To investigate the improvement of fenghuaqianqingcha (FQC) on Benign prostatic hyperplasia (BPH) in mice and the related mechanism.


METHODS
The BPH model was established by subcutaneous injection of testosterone propionate in mice. At the same time, mice were infused into the stomach with FQC in different dosages for three weeks. The mice were sacrificed later, and the prostate index, prostatic wet weight, testosterone levels in plasma and MDA contents, NO levels, GSH levels, as well as oxygen radical absorbance capacity (ORAC) values in prostate were measured and the morphological change of prostatic gland was observed by light microscope to observe the effects of FQC on BPH in mice. And the effect of FQC on 5 alpha-reductase was determinated in vitro by HPLC.


RESULTS
Compared with the BPH model group, all parameters including prostatic index, prostatic wet weight, T levels, MDA contents, ORAC values et. in different experimental groups showed significantly improvement after treatment with FQC. And FQC could inhibit the activity of 5alpha-reductase in vitro significantly.


CONCLUSIONS
FQC has antagonistic effect on BPH induced by testosterone propionate in mice, which may involve its inhibition of the activity of 5 alpha-reductase and accommodate the peroxidation condition.
Rao
Xiang
X
Institute of Traditional Chinese Medicine and Natural products, Jinan University, Guangzhou 510632, China. raoxiang@yeah.net
Bao
Li
L
Feng
Xia
X
Yao
Nan
N
Xie
Guo
G
Hiroshi
Kurihara
K
D000818:Animals; D042944:Cholestenone 5 alpha-Reductase / Q000378:metabolism*; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D011058:Pollen; D011467:Prostate / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D043343:Testosterone Propionate
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013739:Testosterone; D008315:Malondialdehyde; D042944:Cholestenone 5 alpha-Reductase; D005978:Glutathione; D043343:Testosterone Propionate