Taste-guided identification of high potency TRPA1 agonists from Perilla frutescens.
Perilla frutescens is a food plant widely used in Asian cuisine. This plant was investigated for its interesting taste and somatosensory properties. Perillaldehyde and perillaketone are among the components of the aromatic extracts from P. Frutescens. These compounds were shown here to activate the cloned TRPA1 channel when expressed in an heterologous cell system and are therefore suggested to be responsible for the chemesthetic properties of this plant.
Bassoli
Angela
A
DISMA, Dipartimento di Scienze Molecolari Agroalimentari, Università di Milano, Milano, Italy. angela.bassoli@unimi.it
Borgonovo
Gigliola
G
Caimi
Sara
S
Scaglioni
Leonardo
L
Morini
Gabriella
G
Moriello
Aniello Schiano
AS
Di Marzo
Vincenzo
V
De Petrocellis
Luciano
L
D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D039821:Monoterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D031344:Perilla frutescens / Q000737:chemistry*; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D013649:Taste; D014162:Transfection; D050051:Transient Receptor Potential Channels / Q000819:agonists*
D000975:Antioxidants; D039821:Monoterpenes; D010936:Plant Extracts; D050051:Transient Receptor Potential Channels; C033342:perillaldehyde; C015426:perilla ketone