title: Effect of every-other-day fasting on spontaneous chromosomal damage in rat's bone-marrow cells.
abstract: Dietary restriction in experimental rodents, either by calorie restriction (CR) or by every-other-day fasting (EODF), was shown to protect against cancer and increase lifespan. One of the suggested hypotheses to explain the beneficial effects of dietary restriction is that the diet stabilizes the integrity of the genetic information. The effects of EODF on the spontaneous frequency of sister chromatid exchanges (SCE) and chromosomal aberrations (CA) were examined in bone-marrow cells of 3-mo-old Wistar male rats. After 12 wk of EODF diet, significant reduction in the frequency of SCE and total number of CA was observed. Data indicate a protective effect of EODF diet against spontaneous mutations in rats.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Jordan University of Science andTechnology, Irbid, Jordan. azabs@just.edu.jo
authors.forename: Mohammed
authors.initials: M
authors.lastname: Azab
authors.forename: Omar F
authors.initials: OF
authors.lastname: Khabour
authors.forename: Laila
authors.initials: L
authors.lastname: Al-Omari
authors.forename: Mohammad A Y
authors.initials: MA
authors.lastname: Alzubi
authors.forename: Karem
authors.initials: K
authors.lastname: Alzoubi
mesh_terms: D000818:Animals; D000963:Antimetabolites; D001835:Body Weight / Q000502:physiology; D001854:Bone Marrow Cells / Q000473:pathology* / Q000502:physiology*; D001973:Bromodeoxyuridine; D002869:Chromosome Aberrations; D004261:DNA Replication / Q000502:physiology; D005215:Fasting / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012854:Sister Chromatid Exchange / Q000502:physiology
chemical_list: D000963:Antimetabolites; D001973:Bromodeoxyuridine