title: No association of lipase C polymorphisms with Alzheimer's disease.
abstract: Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer's disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism. As such this link makes LIPC a potential functional candidate for AD risk. Previously, three single nucleotide polymorphisms (SNPs) have been investigated in AD with a lack of association reported. To rule out a possible contribution of other variants in LIPC, located at 15q21-q23, we used a detailed fine mapping approach in a German case-control sample. Genotyping of 25 single nucleotide polymorphisms covering the complete LIPC gene and haplotypic analysis revealed no association with AD. Thus, we conclude that LIPC can be excluded as a major functional candidate gene conferring risk to AD.
authors.affiliation: Laboratory of Neurochemistry and Neurogenetics, Department of Psychiatry and Psychotherapy, TU-München, Munich, Germany. simon.laws@lrz.tu-muenchen.de
authors.forename: S M
authors.initials: SM
authors.lastname: Laws
authors.forename: K
authors.initials: K
authors.lastname: Eckart
authors.forename: P
authors.initials: P
authors.lastname: Friedrich
authors.forename: T
authors.initials: T
authors.lastname: Eisele
authors.forename: A
authors.initials: A
authors.lastname: Kurz
authors.forename: H
authors.initials: H
authors.lastname: Förstl
authors.forename: M
authors.initials: M
authors.lastname: Riemenschneider
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008049:Lipase / Q000235:genetics*; D050356:Lipid Metabolism / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D005819:Genetic Markers; C504173:LIPC protein, human; D008049:Lipase