title: Childhood brain insult: can age at insult help us predict outcome?
abstract: Until recently, the impact of early brain insult (EBI) has been considered to be less significant than for later brain injuries, consistent with the notion that the young brain is more flexible and able to reorganize in the context of brain insult. This study aimed to evaluate this notion by comparing cognitive and behavioural outcomes for children sustaining EBI at different times from gestation to late childhood. Children with focal brain insults were categorized according to timing of brain insult, represented by six developmental periods: (i) Congenital (n = 38): EBI: first-second trimester; (ii) Perinatal (n = 33); EBI: third trimester to 1 month post-natal; (iii) Infancy (n = 23): EBI: 2 months-2 years post-birth; (iv) Preschool (n = 19): EBI: 3-6 years; (v) Middle Childhood (n = 31): EBI: 7-9 years; and (vi) Late Childhood (n = 19): EBI: after age 10. Groups were similar with respect to injury and demographic factors. Children were assessed for intelligence, academic ability, everyday executive function and behaviour. Results showed that children with EBI were at increased risk for impairment in all domains assessed. Furthermore, children sustaining EBI before age 2 years recorded global and significant cognitive deficits, while children with later EBI performed closer to normal expectations, suggesting a linear association between age at insult and outcome. In contrast, for behaviour, children with EBI from 7 to 9 years performed worse than those with EBI from 3 to 6 years, and more like those with younger insults, suggesting that not all functions share the same pattern of vulnerability with respect to age at insult.
authors.affiliation: Department of Psychology, Royal Children's Hospital, Flemington Road, Parkville, Victoria, Australia. vicki.anderson@rch.org.au
authors.forename: Vicki
authors.initials: V
authors.lastname: Anderson
authors.forename: Megan
authors.initials: M
authors.lastname: Spencer-Smith
authors.forename: Rick
authors.initials: R
authors.lastname: Leventer
authors.forename: Lee
authors.initials: L
authors.lastname: Coleman
authors.forename: Peter
authors.initials: P
authors.lastname: Anderson
authors.forename: Jackie
authors.initials: J
authors.lastname: Williams
authors.forename: Mardee
authors.initials: M
authors.lastname: Greenham
authors.forename: Rani
authors.initials: R
authors.lastname: Jacobs
mesh_terms: D000293:Adolescent; D000367:Age Factors; D017668:Age of Onset; D001921:Brain / Q000503:physiopathology; D001930:Brain Injuries / Q000151:congenital / Q000503:physiopathology / Q000523:psychology*; D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology; D003072:Cognition Disorders / Q000209:etiology; D002658:Developmental Disabilities / Q000209:etiology*; D005260:Female; D006801:Humans; D007360:Intelligence; D008279:Magnetic Resonance Imaging; D008297:Male; D009473:Neuronal Plasticity; D009483:Neuropsychological Tests; D011379:Prognosis