High ortho preference in Ni-catalyzed cross-coupling of halophenols with alkyl grignard reagents.
High preference of substitution at the position ortho to the hydroxy group was observed for Ni-catalyzed cross-coupling reactions of dihalophenols with alkyl Grignard reagents. Reactions of 2,4-dihalophenols, with various combinations of F, Cl, and Br, were shown to afford ortho-cross-coupled products selectively. In addition, high ortho preference was also observed in competitive cross-coupling reactions between 2-halophenols and other halophenols.
Wang
Jia-Rui
JR
Manabe Initiative Research Unit, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako 351-0198, Japan.
Manabe
Kei
K