[Combination facula photodynamic therapy for circumscribed choroidal hemangioma].
OBJECTIVE
To assess the clinical effect of combination facula photodynamic therapy (PDT) on patients with circumscribed choroidal hemangioma.


METHODS
It was a retrospective case series. Ten cases of circumscribed choroidal hemangioma were diagnosed by ophthalmoscopy, fundus fluorescein angiography and B-scanning ultrasound examination. Clinical data of these cases were retrospectively analyzed. All of these patients had undergone combination facula PDT. The best corrected visual acuity before PDT was FC to 0.3. The maximum diameter of the tumor was 5.5-9.9 mm and averaged 6-8 mm. The maximum thickness of the tumor was 1.1-3.8 mm and averaged 2.7 mm. Four patients suffered from retinal detachment The intravenous injection of visudyne (6 mg/m2) was performed in 10 minutes. Five minutes later, laser irradiation (wave length 689 nm) was performed with the parameters of 50 J/cm2, 83 s, and 2 to 3 spots. The follow-up period was 3.0 to 15.0 months (mean 8.5 months).


RESULTS
The visual acuity in the last examination after treatment was FC-1.0, which was 2-line increased in 7 patients and was steady in 3 patients. B-scanning ultrasound examination showed that the hemangioma was undetectable in 2 patients, and in the other 8 patients,the hemangioma had the diameter of 4.2 to 8.3 mm (average 6.4 mm) and the thickness was 0.5 to 2.7 mm (average 1.9 mm). Retina detachment disappeared in 2 patients


CONCLUSIONS
Combination facula PDT may lead to the shrinking of choroidal hemangioma, disappearance of subretinal fluid, reattachment of retina and the increase or saving of the visual acuity. It is a effective and safe treatment for the macular circumscribed choroidal hemangioma.
Su
Zhao-An
ZA
Eye Center of Affiliated Second Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Shen
Jie
J
Yao
Ke
K
Zhang
Li-Xia
LX
Teng
Yan
Y
D000328:Adult; D002830:Choroid Neoplasms / Q000188:drug therapy*; D005260:Female; D006391:Hemangioma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects / Q000379:methods; D012189:Retrospective Studies