Nonglycosidic agonists of invariant NKT cells for use as vaccine adjuvants.
Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.
Reddy
B Gopal
BG
Fachbereich Chemie, Universität Konstanz, Germany.
Silk
Jonathan D
JD
Salio
Mariolina
M
Balamurugan
Rengarajan
R
Shepherd
Dawn
D
Ritter
Gerd
G
Cerundolo
Vincenzo
V
Schmidt
Richard R
RR
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D014612:Vaccines / Q000276:immunology*
D000276:Adjuvants, Immunologic; D006027:Glycosides; D014612:Vaccines