title: In vitro activity of tigecycline and 10 other antimicrobials against clinical isolates of the genus Corynebacterium.
abstract: We studied the in vitro activity of tigecycline and 10 other commonly used antibiotics against 135 clinical isolates of non-diphtheria Corynebacterium spp. using the Etest system. Tigecycline minimum inhibitory concentrations for 50% and 90% of the organisms (MIC(50) and MIC(90) values, respectively, in mg/L) were: Corynebacterium urealyticum, 0.094 and 0.125; Corynebacterium amycolatum, 0.125 and 2; Corynebacterium jeikeium, 0.094 and 0.75; Corynebacterium coyleae, 0.064 and 0.064; Corynebacterium striatum, 0.064 and 1; Corynebacterium aurimucosum, 0.094 and 0.125; and Corynebacterium afermentans, 0.064 and 0.094. The activities of all other antimicrobials were variable, with good activity of glycopeptides, linezolid, quinupristin/dalfopristin and daptomycin and with resistance to macrolides in a high number of isolates. Tigecycline is a good alternative for the therapy of infections caused by non-diphtheria corynebacteria.
authors.affiliation: Department of Clinical Microbiology, Fundación Jiménez Díaz, Av. Reyes Católicos 2, 28040 Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Fernandez-Roblas
authors.forename: H
authors.initials: H
authors.lastname: Adames
authors.forename: N Z
authors.initials: NZ
authors.lastname: Martín-de-Hijas
authors.forename: D García
authors.initials: DG
authors.lastname: Almeida
authors.forename: I
authors.initials: I
authors.lastname: Gadea
authors.forename: J
authors.initials: J
authors.lastname: Esteban
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003352:Corynebacterium / Q000187:drug effects*; D003354:Corynebacterium Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D008911:Minocycline