A new compound, brefeldin A formylate, from Penicillium sp. strain HLKG-44.
A novel compound named as brefeldin A formylate (1), together with two known compounds, brefeldin A (2) and ergosterol (3), was isolated from the Penicillium sp. strain HLKG-44, which was isolated from polluted environment in Fujian Province. Their structures were identified based on the spectral and X-ray crystallographic analyses. The compound 1, brefeldin A formylate, exhibited moderate cytotoxic activity against the human lung cancer cell line A549 with IC(50) value of 18.9 microg/ml by the MTT assay protocol.
Zhang
Han-Wen
HW
Key Laboratory for Chemical Biology of Fujian Province College of Chemistry and Chemical Engineering, Department of Chemistry, Xiamen University, Xiamen, China.
Cheng
Hong-Ming
HM
Fang
Hua
H
Zhao
Yu-Fen
YF
Fang
Mei-Juan
MJ
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020126:Brefeldin A / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*
D000970:Antineoplastic Agents; C539298:brefeldin A formylate; D020126:Brefeldin A; D004875:Ergosterol