CD147 impacts angiogenesis and metastasis formation.
CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis formation and angiogenesis in this model, CD147 was stably knocked down in B16 cells. This silencing of CD147 expression resulted in a reduced capability of the tumor cells to metastasize to the draining lymph nodes. Notably, the CD147 knock down caused a decreased VEGF expression in vivo accompanied by reduced blood vessel formation. Thus, in the B16 melanoma model, CD147 promotes metastasis formation by induction of angiogenesis in an MMP independent manner.
Voigt
Heike
H
Department of Dermatology, Julius-Maximilians-University, Würzburg, Germany.
Vetter-Kauczok
Claudia S
CS
Schrama
David
D
Hofmann
Uta B
UB
Becker
Jürgen C
JC
Houben
Roland
R
D000818:Animals; D051926:Basigin / Q000502:physiology*; D045744:Cell Line, Tumor; D008546:Melanoma, Experimental / Q000098:blood supply* / Q000556:secondary*; D051379:Mice; D009389:Neovascularization, Pathologic / Q000209:etiology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis
C497887:Bsg protein, mouse; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D051926:Basigin