title: Lifetime substance abuse, family history of alcohol abuse/dependence and novelty seeking in eating disorders: comparison study of eating disorder subgroups.
abstract: OBJECTIVE
  To assess lifetime substance abuse, family history of alcohol abuse/dependence, and novelty seeking in three different eating disorder groups (anorexia nervosa-restrictive; anorexia nervosa-binge eating/purging; anorexia nervosa to bulimia nervosa).
  
  
  METHODS
  A total sample of 371 eating disorder patients participated in the current study. Assessment measures included the prevalence of substance abuse and family history of alcohol abuse/dependence as well as the novelty-seeking subscale of the Temperament and Character Inventory-Revised.
  
  
  RESULTS
  Significant differences across groups were detected for lifetime substance abuse, with anorexia nervosa-restrictive individuals exhibiting a significant lower prevalence than the anorexia nervosa to bulimia nervosa and anorexia nervosa-binge eating/ purging patients (P < 0.01). For family history of alcohol abuse/dependence the same pattern was observed (P = 0.04). Novelty seeking was associated with substance abuse (P = 0.002), with the anorexia nervosa to bulimia nervosa group exhibiting significantly higher scores on the novelty-seeking scale than the other two groups (P < 0.001). But family history of alcohol abuse/dependence was not related to novelty seeking (P = 0.092).
  
  
  CONCLUSIONS
  Lifetime substance abuse appears to be more prevalent in anorexia nervosa patients with bulimic features. Higher novelty-seeking scores may be associated with diagnosis cross-over.
authors.affiliation: Department of Psychiatry, University Hospital of Bellvitge and Ciber Fisiopatologia Obesidad y Nutricion (CIBERobn), Instituto Salud Carlos III, Barcelona, Spain.
authors.forename: Isabel
authors.initials: I
authors.lastname: Krug
authors.forename: Andrea Poyastro
authors.initials: AP
authors.lastname: Pinheiro
authors.forename: Cynthia
authors.initials: C
authors.lastname: Bulik
authors.forename: Susana
authors.initials: S
authors.lastname: Jiménez-Murcia
authors.forename: Roser
authors.initials: R
authors.lastname: Granero
authors.forename: Eva
authors.initials: E
authors.lastname: Penelo
authors.forename: Cristina
authors.initials: C
authors.lastname: Masuet
authors.forename: Zaida
authors.initials: Z
authors.lastname: Agüera
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernández-Aranda
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000453:epidemiology* / Q000523:psychology*; D000855:Anorexia / Q000523:psychology; D015992:Body Mass Index; D002032:Bulimia / Q000523:psychology; D005106:Exploratory Behavior; D005190:Family; D001068:Feeding and Eating Disorders / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D010551:Personality / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D012959:Socioeconomic Factors; D019966:Substance-Related Disorders / Q000453:epidemiology* / Q000523:psychology*; D055815:Young Adult