title: Pseurotin A and its analogues as inhibitors of immunoglobulin E [correction of immunoglobuline E] production.
abstract: A natural product, pseurotin A inhibits IgE production in vitro. Wide variety of chemical modification of pseurotin A was performed. Structure-activity relationship studies of pseurotin analogues elucidated that 10-deoxypseurotin A strongly inhibits IgE production with IC(50) of 0.066 microM. An immunosuppressive activity of another natural product, synerazol was also found.
authors.affiliation: Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan.
authors.forename: Minoru
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Ninomiya
authors.forename: Hirotomo
authors.initials: H
authors.lastname: Akabane
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kushida
authors.forename: Go
authors.initials: G
authors.lastname: Tsujiuchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohyama
authors.forename: Shuichi
authors.initials: S
authors.lastname: Gomi
authors.forename: Keiko
authors.initials: K
authors.lastname: Shito
authors.forename: Takashi
authors.initials: T
authors.lastname: Murata
mesh_terms: D000818:Animals; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D011760:Pyrrolidinones / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D007166:Immunosuppressive Agents; D011760:Pyrrolidinones; C068886:synerazol; D007073:Immunoglobulin E; C012013:pseurotin