Systemic correlates of angiographic coronary artery disease.
Coronary angiography allows a direct evaluation of coronary anatomy. The aim of the present investigation was to search for correlations between the magnitude of coronary artery disease, as assessed by angiography, and a number of systemic parameters. A group of 116 patients (80 male, 36 female) with coronary heart disease diagnosed by angiography, aged 62.0+/-10.5 years, was the subject of an observational study. Correlation and linear regression analysis using coronary artery disease burden (CADB - sum of the percentage of the luminal stenosis encountered in all the lesions of the coronary arterial trees) as dependent variable, and age, sex, plasma calcium, phosphorus, magnesium, glucose, HDL cholesterol, LDL cholesterol, triglycerides, uric acid, estimated glomerular filtration rate and body mass index as independent variables, were carried out. Significant correlation values versus CADB were seen with age (r 0.19, p 0.04), uric acid (r 0.18, p 0.048) and fasting plasma glucose (r 0.33, p<0.001). Linear regression analysis, yielding a global significance level of 0.002, showed a significant value for glucose (p 0.018) and for sex (0.008). In conclusion, among several systemic parameters studied, plasma glucose was found to be correlated to coronary artery atherosclerosis lesions.
Nunes
José Pedro L
JP
Faculdade de Medicina da Universidade do Porto, Porto, Portugal. jplnunes@med.up.pt
Silva
João Carlos
JC
D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D015992:Body Mass Index; D002118:Calcium / Q000097:blood; D002784:Cholesterol / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000188:drug therapy; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016014:Linear Models; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D019370:Observation; D010758:Phosphorus / Q000097:blood; D012307:Risk Factors; D012737:Sex Factors; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D014280:Triglycerides; D014527:Uric Acid; D010758:Phosphorus; D002784:Cholesterol; D008274:Magnesium; D002118:Calcium