title: The prevalence of colonic amyloidosis in baboons. A 22-year survey at a large primate facility.
abstract: BACKGROUND
  Colonic amyloidosis has been previously reported in animals, however its prevalence rate has not yet been explored. The aim of the present work was to assess the prevalence of colonic amyloidosis at the Southwest National Primate Research Center since 1986.
  
  
  METHODS
  Colonic amyloidosis was sought in autopsy material from baboons collected under the diagnosis of systemic amyloidosis.
  
  
  RESULTS
  Between 1986 and 2007, a mean of 3315 baboons per year (range 2578-3931) were housed at the Southwest National Primate Research Center. After examination, colonic amyloidosis was detected in 6 (6.8%) of the 88 baboons with systemic amyloidosis, yielding a prevalence rate of 0.27 cases per year since 1986. Colonic amyloid deposits were found in the interstitial aspect of the lamina propria, often replacing normal mucosal crypts of Lieberkuhn.
  
  
  CONCLUSIONS
  It was observed that only 6.8% of animals with systemic amyloidosis examined between 1986 and 2007 developed colonic amyloidosis. The apparent natural resistance to colonic amyloidosis in baboons presenting systemic amyloidosis deserves to be further investigated.
authors.affiliation: Southwest National Primate Research Center, Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA. Carlos.Rubio@ki.se
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Rubio
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Dick
authors.forename: Gene B
authors.initials: GB
authors.lastname: Hubbard
mesh_terms: D000047:Academies and Institutes / Q000706:statistics & numerical data*; D000686:Amyloidosis / Q000453:epidemiology* / Q000473:pathology; D000818:Animals; D003106:Colon / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology; D010215:Papio; D015995:Prevalence; D011323:Primates