title: Noninvasive transcutaneous bionic baroreflex system prevents severe orthostatic hypotension in patients with spinal cord injury.
abstract: Central baroreflex failure in patients with spinal cord injury results in serious orthostatic hypotension. We examined if transcutaneous electrical stimulation regulates arterial pressure in those patients. We identified skin regions capable of increasing arterial pressure and determined respective transfer function. Using the transfer function, we designed the feedback regulator (i.e., bionic baroreflex system) to control arterial pressure. Orthostatic stress decreased arterial pressure profoundly. Activation of bionic regulator restored and maintained arterial pressure at pre-specified levels. We conclude that the transcutaneous bionic system is noninvasive and capable of stabilizing arterial pressure in patients with spinal cord injury.
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Yoshida
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Murayama
authors.forename: Akiko
authors.initials: A
authors.lastname: Chishaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Sunagawa
mesh_terms: D017704:Baroreflex / Q000502:physiology*; D001698:Biomedical Engineering; D001701:Bionics; D001794:Blood Pressure / Q000502:physiology; D005246:Feedback; D006801:Humans; D007024:Hypotension, Orthostatic / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D013119:Spinal Cord Injuries / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D018667:Tilt-Table Test; D004561:Transcutaneous Electric Nerve Stimulation