Acyltransferases for secreted signalling proteins (Review).
Members of the MBOAT family of multispanning transmembrane enzymes catalyze the acylation of important secreted signalling proteins of the Hedgehog, Wg/Wnt and ghrelin families. Acylation of these substrates occurs during transport through the secretory pathway and plays key roles in their biological activity and spread from producing cells, contributing to the formation of appropriate extracellular concentration gradients. Characterization of these enzymes could lead to their identification as therapeutic targets for diverse human diseases such as cancers, obesity and diabetes.
Chang
Shu-Chun
SC
Section of Molecular Medicine, National Heart & Lung Institute, Imperial College London, London, UK.
Magee
Anthony I
AI
D000217:Acyltransferases / Q000378:metabolism*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D021381:Protein Transport
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D000217:Acyltransferases