title: [Basic mechanisms of hepatocellular injury. Role of inflammatory lipid mediators].
abstract: The presence of a lesion in the cellular parenchyma is common to a large number of chronic liver diseases, such as viral hepatitides, alcoholic hepatitis, chronic cholestasis and steatohepatitis. Although the pathogenesis may vary according to the etiological agent, a series of mechanisms is common to all. Notable among these mechanisms are Kupffer cell activation and inflammatory cell recruitment, free oxygen radical formation and the development of oxidative stress, cytokine production, mainly TNFa and TGFb, and inflammatory mediator release due to arachidonic acid oxidation through the COX-2 and 5-LO pathways.
authors.affiliation: Servicio de Bioquímica y Genética Molecular, Hospital Clínic, Centro de Investigación Biomédica Esther Koplowitz (CIBEK) y CIBER de Enfermedades Hepáticas y Digestivas (CIBEREHD), IDIBAPS, Universitat de Barcelona, Barcelona, Spain. jclaria@clinic.ub.es
authors.forename: Juan
authors.initials: J
authors.lastname: Clària
authors.forename: Raquel
authors.initials: R
authors.lastname: Horrillo
authors.forename: Marcos
authors.initials: M
authors.lastname: Martínez-Clemente
authors.forename: Eva
authors.initials: E
authors.lastname: Morán-Salvador
authors.forename: Esther
authors.initials: E
authors.lastname: Titos
authors.forename: Ana
authors.initials: A
authors.lastname: González-Périz
authors.forename: Natàlia
authors.initials: N
authors.lastname: Ferré
mesh_terms: D000818:Animals; D016207:Cytokines / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000150:complications; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D007728:Kupffer Cells / Q000502:physiology; D008084:Lipoxygenase / Q000502:physiology; D008107:Liver Diseases / Q000201:enzymology / Q000209:etiology* / Q000276:immunology; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology
chemical_list: D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases