title: In vitro evaluation of dentifrice with low fluoride content supplemented with trimetaphosphate.
abstract: One way to reduce dental fluorosis is by reducing the fluoride (F) concentration in dentifrice, but low-F dentifrice should be as effective as a standard dentifrice. This study evaluated in vitro whether the supplementation with sodium trimetaphosphate (TMP) of a dentifrice with low F content (500 microg/g) would provide a similar effect to that of a standard dentifrice. Bovine enamel blocks were submitted to a pH cycling regime incorporating daily exposures to a slurry of dentifrice: a low-F dentifrice with or without 0.1-3.0% TMP; an F-free, phosphate-free dentifrice (negative control), or a dentifrice with 1,100 microg/g F (positive control). The addition of TMP to dentifrice with or without F was associated with higher surface hardness and decreased loss of integrated subsurface hardness after pH cycling. The combination of 1% TMP and 500 microg F/g had a greater effect than the positive control dentifrice. It is concluded that the addition of TMP to the 500-microg F/g dentifrice allowed a similar or larger effect as compared with a standard dentifrice in this in vitro model.
authors.affiliation: Araçatuba Dental School, UNESP-São Paulo State University, Araçatuba, Brazil.
authors.forename: E M
authors.initials: EM
authors.lastname: Takeshita
authors.forename: L P
authors.initials: LP
authors.lastname: Castro
authors.forename: K T
authors.initials: KT
authors.lastname: Sassaki
authors.forename: A C B
authors.initials: AC
authors.lastname: Delbem
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis; D002327:Cariostatic Agents / Q000008:administration & dosage*; D002417:Cattle; D003743:Dental Enamel / Q000737:chemistry*; D003799:Dental Stress Analysis; D003802:Dentifrices / Q000737:chemistry*; D004338:Drug Combinations; D005459:Fluorides / Q000032:analysis; D009050:Fluorosis, Dental / Q000517:prevention & control; D006244:Hardness; D010710:Phosphates / Q000032:analysis; D011122:Polyphosphates / Q000008:administration & dosage*; D012969:Sodium Fluoride / Q000008:administration & dosage*; D017001:Tooth Demineralization / Q000628:therapy; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D004338:Drug Combinations; D010710:Phosphates; D011122:Polyphosphates; D012969:Sodium Fluoride; C009293:trimetaphosphoric acid; D005459:Fluorides; D002118:Calcium