title: Association of cognitive impairment with serum lipid/lipoprotein among Chinese nonagenarians and centenarians.
abstract: The association of cognitive impairment with abnormal levels of serum lipid/lipoprotein in the elderly, in whom there are differences between the old aged 65-84 years and the oldest old aged 85 years or above, has been confirmed by previous studies. However, there are no relevant data from a Chinese oldest old population. In the present study, we observed an association of cognitive impairment with abnormal levels of serum lipid/lipoprotein among very old people using a Chinese cohort aged 90-108 years. The population included 709 unrelated Chinese nonagenarians and centenarians (67.8% women, mean age 93.8 years). The mean score of cognitive function (measured with the 30-item Mini-Mental State Examination, MMSE) was 14.9 (SD 6.0). Comparing abnormal with normal levels of serum lipid/lipoprotein (including triglycerides, total cholesterol, high-density lipoprotein and low-density lipoprotein), in both genders, the odds ratio of cognitive impairment was statistically insignificant. There were no significant differences in levels of lipid/lipoprotein between subjects with and without cognitive impairment. Pearson correlation showed that MMSE scores were not significantly correlated with levels of lipid/lipoprotein. In summary, we found that levels of serum lipid/lipoprotein were not directly correlated with cognitive impairment among Chinese nonagenarians and centenarians.
authors.affiliation: Department of Geriatrics, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Chang-Quan
authors.initials: CQ
authors.lastname: Huang
authors.forename: Bi-Rong
authors.initials: BR
authors.lastname: Dong
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Wu
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zhang
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Wu
authors.forename: Zhen-Chan
authors.initials: ZC
authors.lastname: Lu
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Flaherty
mesh_terms: D000369:Aged, 80 and over; D002681:China / Q000453:epidemiology; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000097:blood* / Q000453:epidemiology / Q000523:psychology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D009483:Neuropsychological Tests; D018570:Risk Assessment
chemical_list: D008055:Lipids; D008074:Lipoproteins