title: Single transpulmonary thermodilution and continuous monitoring of central venous oxygen saturation during off-pump coronary surgery.
abstract: BACKGROUND
  Off-pump coronary artery bypass grafting (OPCAB) requires thorough monitoring of hemodynamics and oxygen transport. Our aim was to find out whether therapeutic guidance during and after OPCAB, using an algorithm based on advanced monitoring, influences perioperative hemodynamic and fluid management as well as the length of post-operative ICU and hospital stay.
  
  
  METHODS
  Patients were randomized into two groups of hemodynamic monitoring: the conventional monitoring (CM) group (n=20) and the advanced monitoring (AM) group (n=20). In the CM group, therapy was guided by central venous pressure, mean arterial pressure (MAP) and heart rate (HR), and in the AM group by the intrathoracic blood volume index, MAP, HR, central venous oxygen saturation (ScvO(2)) and cardiac index (CI). The measurements were performed before and during surgery, and at 2, 4 and 6 h post-operatively.
  
  
  RESULTS
  In the AM group, colloids and dobutamine were given more frequently and were accompanied by increments in ScvO(2), CI and oxygen delivery compared with baseline. The percentage of ephedrine administration was higher in the CM group. The algorithm guided by AM decreased time until achieving the status of 'fit for ICU discharge' and post-operative hospital stay by 15% and 25%, respectively.
  
  
  CONCLUSIONS
  A goal-directed algorithm based on advanced hemodynamic monitoring and continuous measurement of ScvO(2) facilitates early detection and correction of hemodynamic changes and influences the strategy for fluid therapy that can improve the course of post-operative period after coronary artery bypass grafting on the beating heart.
authors.affiliation: Department of Anaesthesiology and Intensive Care Medicine, Northern State Medical University, Troitsky avenue 51, Arkhangelsk, Russian Federation.
authors.forename: A A
authors.initials: AA
authors.lastname: Smetkin
authors.forename: M Y
authors.initials: MY
authors.lastname: Kirov
authors.forename: V V
authors.initials: VV
authors.lastname: Kuzkov
authors.forename: A I
authors.initials: AI
authors.lastname: Lenkin
authors.forename: A V
authors.initials: AV
authors.lastname: Eremeev
authors.forename: V Y
authors.initials: VY
authors.lastname: Slastilin
authors.forename: V V
authors.initials: VV
authors.lastname: Borodin
authors.forename: L J
authors.initials: LJ
authors.lastname: Bjertnaes
mesh_terms: D000368:Aged; D000465:Algorithms; D001810:Blood Volume; D047549:Coronary Artery Bypass, Off-Pump; D005260:Female; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood*; D013815:Thermodilution
chemical_list: D010100:Oxygen