title: [Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample].
abstract: OBJECTIVE
  To establish the association of the vitamin D receptor gene TaqI polymorphism with lepromatous leprosy (LL) in individuals from Sinaloa, Mexico.
  
  
  METHODS
  A 740 bp fragment was amplified from the VDR gene in DNA samples of 71 patients with LL and 144 controls in the Hospital General de Culiacán during 2004-2007. Polymorphism was identified through TaqI endonuclease.
  
  
  RESULTS
  A significant increase in the genotype TT of the VDR gene was observed in patients when compared to controls (p = 0.040; OR = 1.82).
  
  
  CONCLUSIONS
  Our data support the association between the TT genotype and susceptibility to LL in this Mexican population.
authors.affiliation: Centro de Medicina Genómica, Hospital General de Culiacán Dr. Bernardo J. Gastélum, Culiacán, Sinaloa, México.
authors.forename: Jesús Salvador
authors.initials: JS
authors.lastname: Velarde Félix
authors.forename: Silvestre Guadalupe
authors.initials: SG
authors.lastname: Cázarez Salazar
authors.forename: Rafael
authors.initials: R
authors.lastname: Castro Velázquez
authors.forename: José Guadalupe
authors.initials: JG
authors.lastname: Rendón Maldonado
authors.forename: Héctor
authors.initials: H
authors.lastname: Rangel Villalobos
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015440:Leprosy, Lepromatous / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D019914:Taq Polymerase; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol; D019914:Taq Polymerase