title: Activity of posaconazole and other antifungal agents against Mucorales strains identified by sequencing of internal transcribed spacers.
abstract: The antifungal susceptibility profiles of 77 clinical strains of Mucorales species, identified by internal transcribed spacer sequencing, were analyzed. MICs obtained at 24 and 48 h were compared. Amphotericin B was the most active agent against all isolates, except for Cunninghamella and Apophysomyces isolates. Posaconazole also showed good activity for all species but Cunninghamella bertholletiae. Voriconazole had no activity against any of the fungi tested. Terbinafine showed good activity, except for Rhizopus oryzae, Mucor circinelloides, and Rhizomucor variabilis isolates.
authors.affiliation: Servicio de Micologia, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Majadahonda, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Alastruey-Izquierdo
authors.forename: Maria Victoria
authors.initials: MV
authors.lastname: Castelli
authors.forename: Isabel
authors.initials: I
authors.lastname: Cuesta
authors.forename: Araceli
authors.initials: A
authors.lastname: Monzon
authors.forename: Manuel
authors.initials: M
authors.lastname: Cuenca-Estrella
authors.forename: Juan Luis
authors.initials: JL
authors.lastname: Rodriguez-Tudela
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D021903:DNA, Ribosomal Spacer / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009090:Mucorales / Q000187:drug effects* / Q000235:genetics; D014230:Triazoles / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D021903:DNA, Ribosomal Spacer; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B