[The new diagnostic methods of latent tuberculosis infection].
So far the only method of diagnostic assessment of tubercle bacillus infection was a skin tuberculin reaction - but it has low specificity and sensitivity. The article discusses the new tests in the diagnosis of a latent phase of tuberculosis infection and the active form of the disease based on the measurement of interferon gamma (IFN-gamma) released by lymphocyte T after the stimulation by antigens which are specific for M. tuberculosis: ESAT-6, CFP-10. The sensitivity and specificity of QuantiFERON-TB Gold and T-SPOT.TB tests in diagnosis of infection as well as in active form of disease, comparison between the results of tuberculin skin test and the results obtained by the new tests, and problem of incompatibility of results obtained thanks to those tests are discussed.
Kruczak
Katarzyna
K
Klinika Pulmonologii, II Katedra Chorób Wewnetrznych Collegium Medicum Uniwersytetu Jagiellonskiego w Krakowie Kierownik Klinik.
Nizankowska-Mogilnicka
Ewa
E
D000942:Antigens, Bacterial / Q000097:blood* / Q000276:immunology; D001426:Bacterial Proteins / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D012882:Skin Tests; D014374:Tuberculin Test; D014376:Tuberculosis / Q000097:blood* / Q000175:diagnosis*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D015415:Biomarkers; C117940:CFP-10 protein, Mycobacterium tuberculosis; C093276:ESAT-6 protein, Mycobacterium tuberculosis; D007371:Interferon-gamma