title: Inhibiting islet amyloid polypeptide fibril formation by the red wine compound resveratrol.
abstract: GRAPES FOR AMYLOIDS: The red wine compound resveratrol can effectively inhibit the formation of IAPP amyloid that is found in type II diabetes. Our in vitro inhibition results do not depend on the antioxidant activity of resveratrol. Further, the markedly enhanced cell survival in the presence of resveratrol also indicates that the small oligomeric structures that are observed during beta-sheet formation are not toxic and could be off-pathway assembly products.
authors.affiliation: Faculty of Chemistry, Physical Chemistry I, Biophysical Chemistry, TU Dortmund, Dortmund, Germany.
authors.forename: Rajesh
authors.initials: R
authors.lastname: Mishra
authors.forename: Daniel
authors.initials: D
authors.lastname: Sellin
authors.forename: Diana
authors.initials: D
authors.lastname: Radovan
authors.forename: Andrea
authors.initials: A
authors.lastname: Gohlke
authors.forename: Roland
authors.initials: R
authors.lastname: Winter
mesh_terms: D000682:Amyloid / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry*; D002460:Cell Line; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000166:cytology / Q000378:metabolism; D058228:Islet Amyloid Polypeptide; D015394:Molecular Structure; D011487:Protein Conformation; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry*; D014920:Wine
chemical_list: D000682:Amyloid; D000975:Antioxidants; D058228:Islet Amyloid Polypeptide; D013267:Stilbenes; D000077185:Resveratrol