Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.
We report the first large genome-wide association study (GWAS) in a Chinese population to identify susceptibility variants for psoriasis using a two-stage case-control design. In the first stage, we carried out a genome-wide association analysis in 1,139 cases and 1,132 controls of Chinese Han ancestry using Illumina Human 610-Quad BeadChips. In the second stage, we took top SNPs forward for replication in two independent samples of 5,182 cases and 6,516 controls of Chinese Han ancestry, and 539 cases and 824 controls of Chinese Uygur ancestry. In addition to the strong replication for two known susceptibility loci MHC (rs1265181, P = 1.93 x 10(-208), OR = 22.62) and IL12B (rs3213094, P(combined) = 2.58 x 10(-26), OR = 0.78), we identified a new susceptibility locus within the LCE gene cluster on 1q21 (rs4085613, P(combined) = 6.69 x 10(-30), OR = 0.76).
Zhang
Xue-Jun
XJ
Institute of Dermatology and Department of Dermatology at No.1 Hospital, Anhui Medical University, Hefei, Anhui 230022, China.
Huang
Wei
W
Yang
Sen
S
Sun
Liang-Dan
LD
Zhang
Feng-Yu
FY
Zhu
Qi-Xing
QX
Zhang
Fu-Ren
FR
Zhang
Chi
C
Du
Wen-Hui
WH
Pu
Xiong-Ming
XM
Li
Hui
H
Xiao
Feng-Li
FL
Wang
Zai-Xing
ZX
Cui
Yong
Y
Hao
Fei
F
Zheng
Jie
J
Yang
Xue-Qin
XQ
Cheng
Hui
H
He
Chun-Di
CD
Liu
Xiao-Ming
XM
Xu
Li-Min
LM
Zheng
Hou-Feng
HF
Zhang
Shu-Mei
SM
Zhang
Jian-Zhong
JZ
Wang
Hong-Yan
HY
Cheng
Yi-Lin
YL
Ji
Bi-Hua
BH
Fang
Qiao-Yun
QY
Li
Yu-Zhen
YZ
Zhou
Fu-Sheng
FS
Han
Jian-Wen
JW
Quan
Cheng
C
Chen
Bin
B
Liu
Jun-Lin
JL
Lin
Da
D
Fan
Li
L
Zhang
An-Ping
AP
Liu
Sheng-Xiu
SX
Yang
Chun-Jun
CJ
Wang
Pei-Guang
PG
Zhou
Wen-Ming
WM
Lin
Guo-Shu
GS
Wu
Wei-Dong
WD
Fan
Xing
X
Gao
Min
M
Yang
Bao-Qi
BQ
Lu
Wen-Sheng
WS
Zhang
Zheng
Z
Zhu
Kun-Ju
KJ
Shen
Song-Ke
SK
Li
Min
M
Zhang
Xiao-Yan
XY
Cao
Ting-Ting
TT
Ren
Wei
W
Zhang
Xin
X
He
Jun
J
Tang
Xian-Fa
XF
Lu
Shun
S
Yang
Jian-Qiang
JQ
Zhang
Lin
L
Wang
Dan-Ni
DN
Yuan
Feng
F
Yin
Xian-Yong
XY
Huang
Hong-Jie
HJ
Wang
Hai-Feng
HF
Lin
Xin-Yi
XY
Liu
Jian-Jun
JJ
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002878:Chromosomes, Human, Pair 1; D055233:Cornified Envelope Proline-Rich Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D053762:Interleukin-12 Subunit p40 / Q000235:genetics; D015810:Linkage Disequilibrium; D008285:Major Histocompatibility Complex / Q000235:genetics; D008297:Male; D008875:Middle Aged; D005810:Multigene Family; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000235:genetics*; D055815:Young Adult
D055233:Cornified Envelope Proline-Rich Proteins; C500879:IL12B protein, human; D053762:Interleukin-12 Subunit p40