Joint analysis of differential mobility spectrometer and mass spectrometer features for tuberculosis biomarkers.
In this article, we present results of recent efforts to identify biomarkers for tuberculosis using a differential mobility spectrometer (DMS). We focus specifically on the capability of exploiting a data collection system that employs a DMS in parallel with a mass spectrometer. This system permits previously developed algorithms for DMS to be used in conjunction with a device considered a gold-standard for chemical identification, making it a unique discovery tool for the determination of biomarkers.
Cunha
Meredith G
MG
Mission Systems Division, Draper Laboratory, Cambridge, MA 02492, USA. mgerber@draper.com
Hoenigman
Shirley
S
Kanchagar
Chitra
C
Rearden
Preshious
P
Sassetti
Christopher S
CS
Trevejo
Jose M
JM
Keshava
Nirmal
N
D000465:Algorithms; D015415:Biomarkers / Q000032:analysis*; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000175:diagnosis* / Q000378:metabolism*
D015415:Biomarkers