The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction.
BACKGROUND
Macrophage migration inhibitory factor (MIF) is a cytokine implicated in early and advanced atherosclerosis. The aim of this study was to investigate whether polymorphism of MIF gene is associated with myocardial infarction (MI).


METHODS
Single nucleotide polymorphism (SNP) in MIF gene (-173G/C, rs755622) was investigated in Czech (n=219) and Russian (n=240) MI patients and population control from the same geographical areas (Czech, n=137; Russian, n=174). Further, another SNP (rs1007888) located within the 3' flanking region of the MIF gene was investigated in Czech MI patients and control subjects.


RESULTS
There were no significant differences in the distribution of MIF -173G/C genotypes, alleles or carriage rates between case and control groups in either populations. However, the GG genotype of the MIF SNP rs1007888 was associated with MI in Czech female patients (p=0.027).


CONCLUSIONS
Taken together with previous reports, our study suggests that particular MIF gene polymorphisms may contribute to MI susceptibility in females.
Tereshchenko
Irina P
IP
Russian Acad. Medical Science-Siberian branch, Novosibirsk, Russian Federation.
Petrkova
Jana
J
Mrazek
Frantisek
F
Lukl
Jan
J
Maksimov
Vladimir N
VN
Romaschenko
Aida G
AG
Voevoda
Mikhail I
MI
Petrek
Martin
M
D000328:Adult; D000483:Alleles; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors
D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human