title: Cranial mediastinal carcinomas in nine dogs.
abstract: Nine dogs were diagnosed with cranial mediastinal carcinomas. Based on histological and immunohistochemical analysis, four dogs were diagnosed with ectopic follicular cell thyroid carcinomas, one dog with ectopic medullary cell thyroid carcinoma, two dogs with neuroendocrine carcinomas and two dogs with anaplastic carcinomas. Clinical signs and physical examination findings were associated with a space-occupying mass, although one dog was diagnosed with functional hyperthyroidism. Surgical resection was attempted in eight dogs. The cranial mediastinal mass was invasive either into the heart or into the cranial vena cava in three dogs. Resection was complete in six dogs and unresectable in two dogs. All dogs survived surgery, but four dogs developed pulmonary thromboembolism and two dogs died of respiratory complications postoperatively. Adjunctive therapies included pre-operative radiation therapy (n=1) and postoperative chemotherapy (n=3). Three dogs had metastasis at the time of diagnosis, but none developed metastasis following surgery. The overall median survival time was 243 days. Local invasion, pleural effusion and metastasis did not have a negative impact on survival time in this small case series.
authors.affiliation: Animal Cancer Center College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, USA. jliptak@uoguelph.ca
authors.forename: J M
authors.initials: JM
authors.lastname: Liptak
authors.forename: D A
authors.initials: DA
authors.lastname: Kamstock
authors.forename: W S
authors.initials: WS
authors.lastname: Dernell
authors.forename: E J
authors.initials: EJ
authors.lastname: Ehrhart
authors.forename: S A
authors.initials: SA
authors.lastname: Rizzo
authors.forename: S J
authors.initials: SJ
authors.lastname: Withrow
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000662:veterinary; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis* / Q000401:mortality / Q000601:surgery*; D004285:Dogs; D005260:Female; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D011379:Prognosis; D016019:Survival Analysis; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery / Q000662:veterinary; D016896:Treatment Outcome