title: Pneumococcal antibodies in a child with type 14 pneumococcal conjugate vaccine failure.
abstract: We measured the concentration, opsonic activity, and avidity of serotype-specific serum antibodies in a pneumococcal conjugate vaccine (PnCRM7) efficacy trial participant who contracted serotype 14 pneumococcal bacteremia following dose 3 of PnCRM7. Controls included 18 PnCRM7- and 10 MnCC-vaccinated children without invasive pneumococcal disease (IPD). The child with vaccine failure had 4.98mcg/mL of serotype 14 antibodies 10 days before disease onset; these antibodies had greater opsonic activity and lower avidity than those of control PnCRM7 recipients. The child had no booster response to a fourth dose of PnCRM7 for most vaccine serotypes. We conclude that antibody concentration, functional activity and avidity do not predict individual protection against IPD, and immunological correlates of protection are only useful at the population level.
authors.affiliation: Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, 621 N, Washington St., Baltimore, MD, United States. klobrien@jhsph.edu
authors.forename: Katherine L
authors.initials: KL
authors.lastname: O'Brien
authors.forename: Jennifer
authors.initials: J
authors.lastname: Moïsi
authors.forename: Sandra
authors.initials: S
authors.lastname: Romero-Steiner
authors.forename: Patricia
authors.initials: P
authors.lastname: Holder
authors.forename: George M
authors.initials: GM
authors.lastname: Carlone
authors.forename: Raymond
authors.initials: R
authors.lastname: Reid
authors.forename: Mathuram
authors.initials: M
authors.lastname: Santosham
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis*; D000915:Antibody Affinity; D004306:Dose-Response Relationship, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007223:Infant; D008297:Male; D010587:Phagocytosis / Q000276:immunology; D022242:Pneumococcal Vaccines / Q000276:immunology* / Q000627:therapeutic use*; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000276:immunology*; D017211:Treatment Failure; D018074:Vaccines, Conjugate
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D022242:Pneumococcal Vaccines; D018074:Vaccines, Conjugate