Treatment-refractory schizoaffective disorder in a patient with dyke-davidoff-masson syndrome.
Dyke-Davidoff-Masson syndrome, or cerebral hemiatrophy, is a pre- or perinatally acquired entity characterized by predominantly neurologic symptoms, such as seizures, facial asymmetry, contralateral hemiplegia, and mental retardation. Psychiatric symptoms are rarely reported. We report the first case of left cerebral hemiatrophy and a late onset of treatment-resistant schizoaffective disorder after a stressful life event. The patient finally responded well to clozapine. The clinical history and results from structural neuroimaging are highlighted to discuss the possible developmental bias for psychotic disorders.
Amann
Benedikt
B
Benito Menni Complex Assistencial en Salut Mental, Barcelona, Spain. benedikt.amann@med.uni-muenchen.de
García de la Iglesia
Celia
C
McKenna
Peter
P
Pomarol-Clotet
Edith
E
Sanchez-Guerra
Marisa
M
Orth
Michael
M
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001284:Atrophy; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications* / Q000473:pathology; D003024:Clozapine / Q000627:therapeutic use*; D005146:Facial Asymmetry / Q000473:pathology / Q000503:physiopathology; D006429:Hemiplegia / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013577:Syndrome; D016896:Treatment Outcome
D014150:Antipsychotic Agents; D003024:Clozapine