title: Genetic control of programmed cell death (apoptosis) in Drosophila.
abstract: Programmed cell death, or apoptosis, is a highly conserved cellular process that has been intensively investigated in nematodes, flies and mammals. The genetic conservation, the low redundancy, the feasibility for high-throughput genetic screens and the identification of temporally and spatially regulated apoptotic responses make Drosophila melanogaster a great model for the study of apoptosis. Here, we review the key players of the cell death pathway in Drosophila and discuss their roles in apoptotic and non-apoptotic processes.
authors.affiliation: The University of Texas MD Anderson Cancer Center, The Genes and Development Graduate Program, Department of Biochemistry and Molecular Biology, Houston, Texas 77030, USA.
authors.forename: Dongbin
authors.initials: D
authors.lastname: Xu
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Woodfield
authors.forename: Tom V
authors.initials: TV
authors.lastname: Lee
authors.forename: Yun
authors.initials: Y
authors.lastname: Fan
authors.forename: Christian
authors.initials: C
authors.lastname: Antonio
authors.forename: Andreas
authors.initials: A
authors.lastname: Bergmann
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics* / Q000502:physiology; D020169:Caspases / Q000235:genetics / Q000502:physiology; D049109:Cell Proliferation; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology; D004331:Drosophila melanogaster / Q000166:cytology* / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D005260:Female; D017344:Genes, Insect; D008957:Models, Genetic; D009154:Mutation; D009866:Oogenesis; D015398:Signal Transduction; D054875:Ubiquitination
chemical_list: D029721:Drosophila Proteins; C400550:dark protein, Drosophila; D020169:Caspases