Use of diuretics during pregnancy.
OBJECTIVE
Several of my pregnant patients use diuretics for hypertension. I have heard that diuretics cannot be used in pregnancy because of the reduction of plasma volume and the potential for decreasing placental perfusion, as well as a possible diabetogenic effect.


CONCLUSIONS
Many studies--including a meta-analysis of almost 7000 neonates exposed to diuretics during pregnancy--did not find an increased risk of adverse effects, such as birth defects, fetal growth restriction, thrombocytopenia, or diabetes, among neonates exposed to diuretics in utero.
Al-Balas
Mosa'b
M
Bozzo
Pina
P
Einarson
Adrienne
A
D001724:Birth Weight / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D046110:Hypertension, Pregnancy-Induced / Q000188:drug therapy*; D015201:Meta-Analysis as Topic; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome; D047928:Premature Birth; D016032:Randomized Controlled Trials as Topic
D004232:Diuretics