Prognostic value of infection and inflammation markers for late cardiac events in an Iranian sample.
We evaluated the serum levels of IgG antibodies to Helicobacter pylori, Chlamydia pneumoniae and cytomegalovirus and the level of the inflammatory markers C-reactive protein and fibrinogen in 57 patients with acute coronary syndrome, 65 with unstable angina, 60 with stable angina and 44 healthy controls, and whether these markers were associated with cardiac instability 6 months after admission. acute There was a significant increased risk of late coronary events (cardiac death or readmission with coronary events) associated with seropositivity to C. pneumoniae (adjusted odds ratio 2.12; 95% confidence interval: 1.16-4.08). Other parameters were not significantly associated with late cardiac events after adjustment for age, sex, diabetes mellitus, hypertension, hyperlipidaemia and smoking behaviour.
Sarrafzadegan
N
N
Isfahan Cardiovascular Research Centre, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran. nizal.sarrafzadegan@gmail.com
Rezaporian
P
P
Kaypour
M
M
Mohseni
M
M
Sadeghi
M
M
Asgary
S
S
Sabet
B
B
D000328:Adult; D000704:Analysis of Variance; D000907:Antibodies, Bacterial / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000276:immunology / Q000378:metabolism; D016022:Case-Control Studies; D023521:Chlamydophila Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D016993:Chlamydophila pneumoniae / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D005260:Female; D005340:Fibrinogen / Q000276:immunology / Q000378:metabolism; D016481:Helicobacter Infections / Q000097:blood / Q000150:complications* / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007249:Inflammation; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology* / Q000401:mortality; D011237:Predictive Value of Tests; D011379:Prognosis
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D015415:Biomarkers; D007074:Immunoglobulin G; D005340:Fibrinogen; D002097:C-Reactive Protein