Rapid left ventricular recovery after cabergoline treatment in a patient with peripartum cardiomyopathy.
The aetiology of peripartum cardiomyopathy (PPCM) is still largely unknown. Recent evidence suggests that the breakdown products from prolactin can induce cardiomyopathy. Prolactin secretion can be reduced with bromocriptine which had beneficial effects in a small study. We present a case of a patient with PPCM who received cabergoline, a strong and long lasting antagonist of prolactin secretion. Following treatment, her prolactin levels dropped swiftly. N-terminal pro-BNP levels, which had remained high up to that point, dropped within 1 day (7006 to 4408 pg/mL). Echocardiographic left ventricular ejection fraction recovered from 26% on day 4 postpartum to 32% and later 47% on days 2 and 5 after cabergoline treatment. To our knowledge, this is the first description of a case of PPCM in which cabergoline was administered.
de Jong
Jonas S S G
JS
Department of Cardiology, Academic Medical Center, Room B2-238, PO Box 22660, 1100 DD Amsterdam, The Netherlands. j.s.s.g.dejong@amc.nl
Rietveld
Kirsten
K
van Lochem
Laura T
LT
Bouma
Berto J
BJ
D000328:Adult; D000077465:Cabergoline; D009202:Cardiomyopathies / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D004452:Echocardiography; D004873:Ergolines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011247:Pregnancy; D011388:Prolactin; D011644:Puerperal Disorders / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000188:drug therapy*
D004873:Ergolines; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D011388:Prolactin; D000077465:Cabergoline