title: Adjuvant carboplatin for the treatment of intestinal carcinoid in a dog.
abstract: A ten-year-old castrated male dog was presented due to a two-day history of constipation and tenesmus. At physical examination, the dog was depressed and unresponsive. Aggressive behavior was elicited by deep abdominal palpation and a mass was detected during the examination. Imaging studies evidenced a large jejunal mass. The lesion (6 cm in diameter) was surgically removed. The histopathology report gave a diagnosis of completely excised intestinal carcinoid. The patient recovered well from the procedure and was scheduled for adjuvant chemotherapy. The dog received four doses of carboplatin (300 mg/m2) every three weeks without showing signs of toxicity. The dog is still in remission after 18 months and is reassessed on a three-month schedule. This report represents the first description of long-term control of intestinal carcinoid in the dog and the first of adjuvant chemotherapy for this rare and aggressive neoplasm.
authors.affiliation: S.A.F.U. Department, Regina Elena Cancer Institute, Rome, Italy. info@enricospugnini.net
authors.forename: Enrico P
authors.initials: EP
authors.lastname: Spugnini
authors.forename: Marzio
authors.initials: M
authors.lastname: Gargiulo
authors.forename: Renato
authors.initials: R
authors.lastname: Assin
authors.forename: Alfredo
authors.initials: A
authors.lastname: D'Avino
authors.forename: Pasquale
authors.initials: P
authors.lastname: Mellone
authors.forename: Gennaro
authors.initials: G
authors.lastname: Citro
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Cardelli
authors.forename: Alfonso
authors.initials: A
authors.lastname: Baldi
mesh_terms: D000374:Aggression; D000818:Animals; D016190:Carboplatin / Q000627:therapeutic use*; D002276:Carcinoid Tumor / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D003248:Constipation / Q000209:etiology / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007414:Intestinal Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D007583:Jejunum / Q000473:pathology; D008297:Male; D009919:Orchiectomy
chemical_list: D016190:Carboplatin