Resorbable versus titanium plates for facial fractures.
BACKGROUND
Rigid internal fixation of the jaw bones is a routine procedure for the management of facial fractures. Titanium plates and screws are routinely used for this purpose. The limitations of this system has led to the development of plates manufactured from bioresorbable materials which, in some cases, omits the necessity for the second surgery. However, concerns remain about the stability of fixation and the length of time required for their degradation and the possibility of foreign body reactions.


OBJECTIVE
To compare the effectiveness of bioresorbable fixation systems with titanium systems for the management of facial fractures.


METHODS
We searched the following databases: The Cochrane Oral Health Group's Trials Register (to 20th August 2008), the Cochrane Central Register of Controlled Trials (CENTRAL) (The Cochrane Library 2008, Issue 3), MEDLINE (1950 to 20th August 2008), EMBASE (from 1980 to 20th August 2008), http://www.clinicaltrials.gov/ and http://www.controlled-trials.com (to 20th August 2008).


METHODS
Randomised controlled trials comparing resorbable versus titanium fixation systems used for facial fractures.


METHODS
Retrieved studies were independently screened by two review authors. Results were to be expressed as random-effects models using mean differences for continuous outcomes and risk ratios for dichotomous outcomes with 95% confidence intervals. Heterogeneity was to be investigated including both clinical and methodological factors.


RESULTS
The search strategy retrieved 53 potentially eligible studies. None of the retrieved studies met our inclusion criteria and all were excluded from this review. One study is awaiting classification as we failed to obtain the full text copy. Three ongoing trials were retrieved, two of which were stopped before recruiting the planned number of participants. In one study, the excess complications in the resorbable arm was declared as the reason for stopping the trial.


CONCLUSIONS
This review illustrates that there are no published randomised controlled clinical trials relevant to this review question. There is currently insufficient evidence for the effectiveness of resorbable fixation systems compared with conventional titanium systems for facial fractures. The findings of this review, based on the results of the aborted trials, do not suggest that resorbable plates are as effective as titanium plates. In future, the results of ongoing clinical trials may provide high level reliable evidence for assisting clinicians and patients for decision making. Trialists should design their studies accurately and comprehensively to meet the aims and objectives defined for the study.
Dorri
Mojtaba
M
Department of Epidemiology & Public Health, University College London (UCL), 1-19 Torrington Place, London, UK, WC1E 6BT. mojtabadorri@yahoo.com
Nasser
Mona
M
Oliver
Richard
R
D020341:Absorbable Implants; D001860:Bone Plates; D005147:Facial Bones / Q000293:injuries* / Q000601:surgery; D005593:Fracture Fixation, Internal; D006801:Humans; D012887:Skull Fractures / Q000601:surgery*; D014025:Titanium
D014025:Titanium