Spatial signaling networks converge at the adaptor protein Shc.
Endothelial cells, which are located at the interface between the blood and the vessel wall, respond dynamically to a variety of stimuli initiating signaling cascades that regulate cardiovascular development, physiology and pathology. These inputs include soluble factors that bind to their receptors, integrin-matrix interactions, cell-cell contacts and mechanical forces due to the flowing blood. While these stimuli can mediate unique downstream signals, it is well-accepted that signaling pathways are highly interwoven into complex signaling networks with several levels of cross-talk, integration and coordination. Recent studies suggest that several signaling networks coalesce at the adaptor protein Shc.
Sweet
Daniel Timothy
DT
Department of Cell and Molecular Physiology and Program in Genetics and Molecular Biology, Chapel Hill, North Carolina 27599, USA. etzima@med.unc.edu
Tzima
Ellie
E
D000818:Animals; D002448:Cell Adhesion; D021982:Cell-Matrix Junctions / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D055765:Shc Signaling Adaptor Proteins / Q000378:metabolism*; D015398:Signal Transduction
D055765:Shc Signaling Adaptor Proteins; D011505:Protein-Tyrosine Kinases