Netilmicin in the neonate: pharmacokinetic analysis and influence of parenteral nutrition.
OBJECTIVE
The aim of this study was to investigate the impact of parenteral nutrition on netilmicin pharmacokinetics in critically ill neonates during the first week of life.


METHODS
A total of 200 neonates (gestational ages 26.4-41 weeks) treated with netilmicin (4-5 mg/kg in extended dosing intervals) for postnatal sepsis in the first week of life received either fluid therapy or parenteral nutrition. Netilmicin peak and trough serum concentrations were monitored and netilmicin pharmacokinetic parameters were compared with and without parenteral nutrition.


RESULTS
There were no statistically significant differences between the pharmacokinetic parameters of netilmicin (volume of distribution, elimination half-life, clearance) in critically ill neonates >32 weeks during the first week of life that received either fluid therapy or parenteral nutrition. For neonates <32 weeks this comparison was not feasible as the majority were parenterally fed.


CONCLUSIONS
Provision of parenteral nutrition (versus fluid therapy) in critically ill neonates >32 weeks did not significantly affect netilmicin pharmacokinetics and therefore does not require modification of recommended netilmicin dosage regimens.
Bacopoulou
Flora
F
Faculty of Pharmacy, Laboratory of Biopharmaceutics and Pharmacokinetics, University of Athens, Panepistimiopolis, Athens, 157 71, Greece. bacopouf@hotmail.com
Skouroliakou
Maria
M
Markantonis
Sophia L
SL
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D016638:Critical Illness; D005260:Female; D018565:Food-Drug Interactions; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009428:Netilmicin / Q000493:pharmacokinetics* / Q000627:therapeutic use; D010288:Parenteral Nutrition; D011446:Prospective Studies; D018805:Sepsis / Q000188:drug therapy; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D009428:Netilmicin