title: Citrinamides, new potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938.
abstract: Two new aromatic alkaloids, designated citrinamides A and B, were isolated from the culture broth of Penicillium sp. FKI-1938 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analysis, including NMR and amino acid analysis. Citrinamides A and B showed moderate potentiation of miconazole activity against Candida albicans.
authors.affiliation: Kitasato Institute for Life Sciences & Graduate School of Infection Control Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Sakabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D000813:Anilides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D004357:Drug Synergism; D005285:Fermentation; D005973:Glutamine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology*; D010407:Penicillium / Q000378:metabolism*
chemical_list: D000813:Anilides; D000935:Antifungal Agents; C535079:citrinamide A; C535080:citrinamide B; D005973:Glutamine; D008825:Miconazole