title: Maxillary sinus grafting with a nano-structured biomaterial: preliminary clinical and histological results.
abstract: BACKGROUND
  In this study the potential of a new and entirely synthetic, nano-structured hydroxyapatite-based biomaterial for sinus floor augmentation is evaluated.
  
  
  METHODS
  20 sinus floor elevations were carried out in a total of 20 patients. After a healing period of 6 months, in 10 cases cylinder-shaped bone biopsies were taken from the augmented maxillary region using trephine burs.
  
  
  RESULTS
  The healing period progressed without any complications. General and specific histological analysis of the bone biopsies showed a high osteoclast activity at the margin of the biomaterial which was well integrated into the newly formed bone.
  
  
  CONCLUSIONS
  This study demonstrates that new trabecular bone is formed after grafting with the nanocrystalline bone substitute after 6 months. Ongoing histomorphological studies are necessary to quantify the biomaterial-bone ratio and the exact amount of newly built bone in the augmented cavity after 6 months.
authors.affiliation: Department for Oral, Cranio-Maxillofacial and Facial Plastic Surgery, Medical Center of Johann Wolfgang Goethe University Frankfurt, Frankfurt am Main, Germany. sstuebinger@uhbs.ch
authors.forename: S
authors.initials: S
authors.lastname: Stübinger
authors.forename: S
authors.initials: S
authors.lastname: Ghanaati
authors.forename: C
authors.initials: C
authors.lastname: Orth
authors.forename: U
authors.initials: U
authors.lastname: Hilbig
authors.forename: B
authors.initials: B
authors.lastname: Saldamli
authors.forename: S
authors.initials: S
authors.lastname: Biesterfeld
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirkpatrick
authors.forename: R A
authors.initials: RA
authors.lastname: Sader
mesh_terms: D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods; D018786:Bone Substitutes / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008443:Maxillary Sinus / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D049329:Nanostructures / Q000627:therapeutic use*; D016348:Osseointegration; D019736:Prostheses and Implants; D055815:Young Adult
chemical_list: D018786:Bone Substitutes; D015921:Dental Implants; D017886:Durapatite