title: Synthesis of the positron-emitting radiotracer [(18)F]-2-fluoro-2-deoxy-D-glucose from resin-bound perfluoroalkylsulfonates.
abstract: A new approach to the synthesis of 2-fluoro-2-deoxy-d-glucose (FDG, [(19/18)F]-) is described, which employs supported perfluoroalkylsulfonate precursors , where the support consists of insoluble polystyrene resin beads. Treatment of these resins with [(19)F]fluoride ion afforded protected FDG [(19)F]- as the major product, and the identities of the main byproducts were determined. Acidic removal of the acetal protecting groups from [(19)F]- was shown to produce [(19)F]FDG. The method has been applied to the efficient radiosynthesis of the imaging agent [(18)F]FDG, and was shown to produce the radiochemical tracer in good radiochemical yield (average 73%, decay corrected).
authors.affiliation: School of Chemistry, University of Southampton, Highfield, Southampton, UKSO17 1BJ.
authors.forename: Lynda J
authors.initials: LJ
authors.lastname: Brown
authors.forename: Nianchun
authors.initials: N
authors.lastname: Ma
authors.forename: Denis R
authors.initials: DR
authors.lastname: Bouvet
authors.forename: Sue
authors.initials: S
authors.lastname: Champion
authors.forename: Alex M
authors.initials: AM
authors.lastname: Gibson
authors.forename: Yulai
authors.initials: Y
authors.lastname: Hu
authors.forename: Alex
authors.initials: A
authors.lastname: Jackson
authors.forename: Imtiaz
authors.initials: I
authors.lastname: Khan
authors.forename: Nicolas
authors.initials: N
authors.lastname: Millot
authors.forename: Amy C
authors.initials: AC
authors.lastname: Topley
authors.forename: Harry
authors.initials: H
authors.lastname: Wadsworth
authors.forename: Duncan
authors.initials: D
authors.lastname: Wynn
authors.forename: Richard C D
authors.initials: RC
authors.lastname: Brown
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D017738:Alkanesulfonic Acids / Q000737:chemistry*; D005459:Fluorides / Q000737:chemistry; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis*; D011854:Radiochemistry
chemical_list: D000180:Acrylic Resins; D017738:Alkanesulfonic Acids; D019788:Fluorodeoxyglucose F18; D005459:Fluorides