Selective activation of the sympathetic ganglia by centrally administered corticotropin-releasing factor in rats.
The sympathetic efferent pathway projects to the sympathetic ganglia and the adrenal medulla. In this study, we examined centrally administered corticotropin-releasing factor (CRF)-induced neuronal activation of noradrenergic postganglionic neurons in several kinds of the sympathetic ganglia (superior cervical, stellate and celiac ganglia) in anesthetized rats. CRF significantly increased c-Fos expression in the celiac and stellate ganglia, with more pronounced effect on the celiac ganglion. On the other hand, CRF had no effect on c-Fos expression in the superior cervical ganglion even at a higher dose. These results suggest that brain CRF selectively regulates neuronal activity of each sympathetic ganglion.
Usui
Daisuke
D
Department of Pharmacology, School of Medicine, Kochi University, Nankoku, Kochi 783-8505, Japan; Department of Pediatrics, School of Medicine, Kochi University, Nankoku, Kochi 783-8505, Japan.
Yamaguchi-Shima
Naoko
N
Okada
Shoshiro
S
Shimizu
Takahiro
T
Wakiguchi
Hiroshi
H
Yokotani
Kunihiko
K
D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D005728:Ganglia, Sympathetic / Q000187:drug effects* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D016762:Genes, fos; D007276:Injections, Intraventricular; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013233:Stellate Ganglion / Q000187:drug effects / Q000378:metabolism; D013312:Stress, Physiological / Q000502:physiology; D017783:Superior Cervical Ganglion / Q000187:drug effects / Q000378:metabolism
D009419:Nerve Tissue Proteins; D016760:Proto-Oncogene Proteins c-fos; D000324:Adrenocorticotropic Hormone