Tetra-arsenic oxide (Tetras) enhances radiation sensitivity of solid tumors by anti-vascular effect.
Tetras (tetra-arsenic oxide, As(4)O(6)) is a derivative of arsenic used in Korean traditional medicine for the treatment of cancer, but its mechanism remains largely undefined. Recently, a similar arsenic derivative, diarsenic trioxide (As(2)O(3), ATO), has been shown to mediate anti-tumor activity, therefore reigniting interest in the therapeutic effect of arsenic compounds. Here we report that Tetras can effectively mediate an anti-vascular effect on tumors, leading to delay in tumor growth and increased survival. Our study demonstrates for the first time the potential use of Tetras as a radiation therapy enhancement agent for solid tumors. These findings reveal an unappreciated role of Tetras in cancer therapy and its potential application to radiotherapy in achieving local tumor control.
Park
Sae-Gwang
SG
Department of Microbiology, Busanpaik Hospital, Inje University College of Medicine, 633-165 Gaegum-Dong, Jin-Gu, Busan, Republic of Korea. micpsg@inje.ac.kr
Jung
Jeong-Joo
JJ
Won
Hae Jeong
HJ
Kang
Mi Seon
MS
Seo
Su-Kil
SK
Choi
Il-Whan
IW
Eun
Choong Ki
CK
Ahn
Ki Jung
KJ
Park
Cheol Woo
CW
Lee
Soo-Woong
SW
Lew
Young S
YS
Bae
Ill-Ju
IJ
Choi
In-Hak
IH
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009303:Nasopharyngeal Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000532:radiotherapy*; D009368:Neoplasm Transplantation; D018307:Neoplasms, Squamous Cell / Q000098:blood supply / Q000188:drug therapy* / Q000532:radiotherapy*; D010087:Oxides / Q000627:therapeutic use*; D011836:Radiation Tolerance / Q000187:drug effects*; D014183:Transplantation, Heterologous
D020533:Angiogenesis Inhibitors; D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide