title: Low dose megavoltage cone beam computed tomography with an unflattened 4 MV beam from a carbon target.
abstract: Megavoltage cone beam computed tomography (MVCBCT) is routinely used for visualizing anatomical structures and implanted fiducials for patient positioning in radiotherapy. MVCBCT using a 6 MV treatment beam with high atomic number (Z) target and flattening filter in the beamline, as done conventionally, has lower image quality than can be achieved with a MV beam due to heavy filtration of the low-energy bremsstrahlung. The unflattened beam of a low Z target has an abundance of diagnostic energy photons, detected with modern flat panel detectors with much higher efficiency given the same dose to the patient. This principle guided the development of a new megavoltage imaging beamline (IBL) for a commercial radiotherapy linear accelerator. A carbon target was placed in one of the electron primary scattering foil slots on the target-foil slide. A PROM on a function controller board was programed to put the carbon target in place for MVCBCT. A low accelerating potential of 4.2 MV was used for the IBL to restrict leakage of primary electrons through the target such that dose from x rays dominated the signal in the monitor chamber and the patient surface dose. Results from phantom and cadaver images demonstrated that the IBL had much improved image quality over the treatment beam. For similar imaging dose, the IBL improved the contrast-to-noise ratio by as much as a factor of 3 in soft tissue over that of the treatment beam. The IBL increased the spatial resolution by about a factor of 2, allowing the visualization of finer anatomical details. Images of the cadaver contained useful information with doses as low as 1 cGy. The IBL may be installed on certain models of linear accelerators without mechanical modification and results in significant improvement in the image quality with the same dose, or images of the same quality with less than one-third of the dose.
authors.affiliation: Department of Radiation Oncology, UCSF Comprehesive Cancer Center, San Francisco, California 94143-1708, USA. bfaddegon@radonc.ucsf.edu
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Faddegon
authors.forename: Vincent
authors.initials: V
authors.lastname: Wu
authors.forename: Jean
authors.initials: J
authors.lastname: Pouliot
authors.forename: Bijumon
authors.initials: B
authors.lastname: Gangadharan
authors.forename: Ali
authors.initials: A
authors.lastname: Bani-Hashemi
mesh_terms: D002244:Carbon / Q000737:chemistry*; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D003952:Diagnostic Imaging / Q000379:methods; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D004867:Equipment Design; D006801:Humans; D009010:Monte Carlo Method; D010315:Particle Accelerators; D019047:Phantoms, Imaging; D017785:Photons; D011878:Radiotherapy / Q000379:methods*; D012542:Scattering, Radiation; D013193:Stainless Steel; D014965:X-Rays
chemical_list: D013193:Stainless Steel; D002244:Carbon