title: Making all the children above average: ethical and regulatory concerns for pediatricians in pediatric enhancement research.
abstract: Building on the knowledge generated by the long history of disease-oriented research, the next few decades will witness an explosion of biomedical enhancements to make people faster, stronger, smarter, less forgetful, happier, prettier, and live longer. Growing interest in pediatric enhancements is likely to stimulate the conduct of enhancement research involving children. However, guidelines for the protection of human subjects were developed for investigations of therapeutic modalities. To date, virtually no attention has been paid to whether these rules would be appropriate for investigations to establish the safety and efficacy of technologies intended for enhancement rather than therapeutic uses and, if not, whether ethically acceptable rules could be designed. This article discusses whether the current guidelines for pediatric research provide appropriate protections for pediatric subjects in enhancement research and considers what additional protections might be necessary.
authors.affiliation: School of Law and Department of Bioethics, Case Western Reserve University, Cleveland, Ohio 44106, USA. jessica.berg@case.edu
authors.forename: Jessica W
authors.initials: JW
authors.lastname: Berg
authors.forename: Maxwell J
authors.initials: MJ
authors.lastname: Mehlman
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Rubin
authors.forename: Eric
authors.initials: E
authors.lastname: Kodish
mesh_terms: D024803:Biomedical Enhancement / Q000941:ethics*; D035843:Biomedical Research / Q000941:ethics* / Q000331:legislation & jurisprudence*; D002648:Child; D006801:Humans; D033281:Nontherapeutic Human Experimentation / Q000941:ethics* / Q000331:legislation & jurisprudence*; D010372:Pediatrics; D014481:United States