title: [Effect of double anaesthetic Colicursi (tetracaine 0.1% and oxybuprocaine 0.4%) on central and paracentral corneal thickness].
abstract: OBJECTIVE
  To study the effect of 1 drop of combined topical anaesthesia (tetracaine 0.1% and oxybuprocaine 0.4%) on central corneal thickness (CCT) values and at 2.5 mm from the corneal centre in nasal, temporal, superior and inferior hemi meridians, monitored by Orbscan over a period of 16 minutes.
  
  
  METHODS
  The corneal thickness of 12 right eyes of 12 young healthy men was determined using the Orbscan Topography System. Values were determined at the centre and paracentral regions 2.5 mm from the centre every 2 minutes for 16 minutes before and after the administration of 1 drop of double anaesthetic Colircusi which contains tetracaine 0.1% and oxybuprocaine 0.4%.
  
  
  RESULTS
  There was no obvious trend of central and paracentral corneal thickness value change before and after administration of Colircusi (paired ANOVA, p>0.05). Although corneal thickness variation was not statistically significant, higher differences were observed at the 6 minute time-point for CCT and at 8 minutes for nasal paracentral corneal thickness.
  
  
  CONCLUSIONS
  One drop of double anaesthetic Colircusi with tetracaine 0.1% and oxibuprocaine 0.4% does not produce any significant change in central corneal thickness or in paracentral regions 2.5 mm from the centre (nasal, temporal, superior and inferior hemi meridians).
authors.affiliation: Escuela Universitaria de Optica y Optometría, Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Díaz-Rey
authors.forename: M J
authors.initials: MJ
authors.lastname: Giráldez
authors.forename: C
authors.initials: C
authors.lastname: García-Resúa
authors.forename: E
authors.initials: E
authors.lastname: Yebra-Pimentel
mesh_terms: D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects* / Q000648:ultrastructure; D019781:Corneal Topography; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D009883:Ophthalmic Solutions; D011343:Procaine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013748:Tetracaine / Q000008:administration & dosage / Q000494:pharmacology; D055815:Young Adult
chemical_list: D000779:Anesthetics, Local; C545344:Colicursi; D009883:Ophthalmic Solutions; D013748:Tetracaine; D011343:Procaine