title: Empirical model of the photon path length for a single fiber reflectance spectroscopy device.
abstract: A reflectance spectroscopic device that utilizes a single fiber for both light delivery and collection has advantages over classical multi-fiber probes. This study presents a novel empirical relationship between the single fiber path length and the combined effect of both the absorption coefficient, mua (range: 0.1-6 mm-1), and the reduced scattering coefficient, micro's (range: 0.3 - 10 mm-1), for different anisotropy values (0.75 and 0.92), and is applicable to probes containing a wide range of fiber diameters (range: 200-2000 microm). The results indicate that the model is capable of accurately predicting the single fiber path length over a wide range (r = 0.995; range: 180-3940 microm) and predictions do not show bias as a function of either microa or micro's .
authors.affiliation: Center for Optical Diagnostics and Therapy, Department of Radiation Oncology, Erasmus Medical Center, PO Box 2040, 3000 CA Rotterdam, The Netherlands. s.kanick@erasmusmc.nl
authors.forename: S C
authors.initials: SC
authors.lastname: Kanick
authors.forename: H J C M
authors.initials: HJ
authors.lastname: Sterenborg
authors.forename: A
authors.initials: A
authors.lastname: Amelink