[Levels of transition on maternal transferred measles antibody in infants in 3 cities in China].
OBJECTIVE
To understand the epidemiological characteristics of age distribution of measles and related policies on measles vaccines (live; MV) in infants through analyzing the antibody levels of comparison in maternal-infant pairs. Transition of immunity in infants was also studied to provide theoretic basis for measles immunization strategy and to reduce the incidence of month-old infants.


METHODS
In cities of Ningbo, Harbin, and Jinan from Zhejiang, Heilongjiang and Shandong provinces, data was collected from 2004 to 2007 and analyzed regarding the epidemic situation of measles. Studies on maternal-transferred measles antibody were carried our sero-epidemiologically.


RESULTS
Most of the measles cases were found among babies younger than 12 months, and the incidence of < 1 year olds had been increasing. The distribution was dominated by 5 - 8 month olds in infant measles cases. The positive rate and GRMT of measles antibody in newborns were 89.3 percent and 738.93. The positive rate of the measles antibody and GMRT of the 6-month infant were 6.9% and 6.89, while 6.7% and 3.69 in 8-month infant. There was a declining trend of the positive rate of the measles antibody during the newborns to 8-month infant. The positive rate and GRMT of measles antibody in mothers were 84.3 percent and 516.94. Mother's measles antibodies mainly to be at low and moderate level, which accounted for 50.4 percent and 30.3 percent respectively, the correlation coefficient between mother and infant was 0.840.


CONCLUSIONS
Maternal-transferred measles antibody decreased as the growth of infants. The positive rates of measles antibody were quite low in 6-month and 8-month olds which were the age range that needs most attention.
Xu
Guo-zhang
GZ
Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, China.
Ma
Rui
R
Xu
Hong-jie
HJ
Ma
Yan-hui
YH
Dong
Hong-jun
HJ
Li
Yan
Y
Hu
Feng-xia
FX
Ni
Hong-xia
HX
Bian
Guo-lin
GL
Liang
Ying
Y
Liu
Lan-zheng
LZ
Zhou
Shao-ying
SY
Huai
Qing-jie
QJ
Han
Xiu-yun
XY
D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D008457:Measles / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control; D011247:Pregnancy; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires
D000914:Antibodies, Viral; D007074:Immunoglobulin G