title: Prolonged remission of disseminated atypical adenomatous hyperplasia under gefitinib.
abstract: Atypical adenomatous hyperplasia (AAH) is a putative precursor of bronchioloalveolar carcinoma (BAC) and adenocarcinoma of the lung, developing from terminal respiratory unit cells. AAH and BAC lesions typically present as ground-glass opacities at spiral chest computed tomography. Epidermal growth factor receptor polysomy/mutations, conferring higher sensitivity to Gefitinib, are frequent in BAC but less common in AAH. We describe an interesting case of disseminated AAH showing a sustained remission under Gefitinib therapy.
authors.affiliation: Department of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy. ugo.pastorino@istitutotumori.mi.it
authors.forename: Ugo
authors.initials: U
authors.lastname: Pastorino
authors.forename: Elisa
authors.initials: E
authors.lastname: Calabrò
authors.forename: Elena
authors.initials: E
authors.lastname: Tamborini
authors.forename: Alfonso
authors.initials: A
authors.lastname: Marchianò
authors.forename: Marta
authors.initials: M
authors.lastname: Orsenigo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Fabbri
authors.forename: Gabriella
authors.initials: G
authors.lastname: Sozzi
authors.forename: Silvia
authors.initials: S
authors.lastname: Novello
authors.forename: Filippo
authors.initials: F
authors.lastname: De Marinis
mesh_terms: D002282:Adenocarcinoma, Bronchiolo-Alveolar / Q000188:drug therapy* / Q000235:genetics / Q000556:secondary; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000235:genetics; D005260:Female; D000077156:Gefitinib; D006801:Humans; D006965:Hyperplasia; D008168:Lung / Q000473:pathology*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D016133:Polymerase Chain Reaction; D011799:Quinazolines / Q000627:therapeutic use*; D012074:Remission Induction; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D066246:ErbB Receptors; D000077156:Gefitinib