Magnolol enhances pentobarbital-induced sleeping behaviors: possible involvement of GABAergic systems.
This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABA(A) receptor alpha-subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of beta- or gamma-subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital-induced sleeping behaviors through the activation of GABAergic systems.
Ma
Hong
H
College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea.
Kim
Chung-Soo
CS
Ma
Yuan
Y
Nam
Sang-Yoon
SY
Kim
Dong-Seon
DS
Woo
Sung-Sick
SS
Hong
Jin-Tae
JT
Oh
Ki-Wan
KW
D000818:Animals; D001713:Biphenyl Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology; D002712:Chlorides / Q000378:metabolism; D005968:Glutamate Decarboxylase / Q000378:metabolism; D017705:Lignans / Q000302:isolation & purification / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015394:Molecular Structure; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism; D012890:Sleep / Q000187:drug effects*
D001713:Biphenyl Compounds; D002712:Chlorides; D017705:Lignans; D011963:Receptors, GABA-A; C005498:magnolol; D005968:Glutamate Decarboxylase; D010424:Pentobarbital