title: Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit.
abstract: A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenylpyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds.
authors.affiliation: University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia.
authors.forename: Ivan
authors.initials: I
authors.lastname: Damljanović
authors.forename: Mirjana
authors.initials: M
authors.lastname: Vukićević
authors.forename: Niko
authors.initials: N
authors.lastname: Radulović
authors.forename: Radosav
authors.initials: R
authors.lastname: Palić
authors.forename: Ernst
authors.initials: E
authors.lastname: Ellmerer
authors.forename: Zoran
authors.initials: Z
authors.lastname: Ratković
authors.forename: Milan D
authors.initials: MD
authors.lastname: Joksović
authors.forename: Rastko D
authors.initials: RD
authors.lastname: Vukićević
mesh_terms: D000588:Amines / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002738:Chloroquine / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D004351:Drug Resistance / Q000187:drug effects; D005296:Ferrous Compounds / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007097:Imines / Q000494:pharmacology; D000075163:Metallocenes; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005296:Ferrous Compounds; D007097:Imines; D000075163:Metallocenes; D011720:Pyrazoles; D002738:Chloroquine; C004998:ferrocene