title: Cortical recording with polypyrrole microwire electrodes.
abstract: The ability to record from the same neuron for extended periods of time is essential to understanding how the brain reorganizes during learning. Conventional chronic recording microelectrodes are made from metal or silicon. However, the large stiffness mismatch between the electrodes and brain tissue causes shear-induced inflammation, limiting long-term recording stability. The flexibility of polypyrrole microwire has the potential to improve the chronic recording stability by minimizing the stiffness mismatch. In this paper, we report the implantation of a conducting polymer microwire electrode in a rodent brain, and the successful recording of cortical activity using such an electrode.
authors.affiliation: Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, 02139 USA. chrisbae@mit.edu
authors.forename: Woong J
authors.initials: WJ
authors.lastname: Bae
authors.forename: Bryan P
authors.initials: BP
authors.lastname: Ruddy
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Richardson
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hunter
authors.forename: Emilio
authors.initials: E
authors.lastname: Bizzi
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D017076:Computer-Aided Design; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008839:Microelectrodes; D008904:Miniaturization; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D011108:Polymers; D011758:Pyrroles; C067635:polypyrrole