title: The macrophage migration inhibitory factor (MIF) gene polymorphism in Czech and Russian patients with myocardial infarction.
abstract: BACKGROUND
  Macrophage migration inhibitory factor (MIF) is a cytokine implicated in early and advanced atherosclerosis. The aim of this study was to investigate whether polymorphism of MIF gene is associated with myocardial infarction (MI).
  
  
  METHODS
  Single nucleotide polymorphism (SNP) in MIF gene (-173G/C, rs755622) was investigated in Czech (n=219) and Russian (n=240) MI patients and population control from the same geographical areas (Czech, n=137; Russian, n=174). Further, another SNP (rs1007888) located within the 3' flanking region of the MIF gene was investigated in Czech MI patients and control subjects.
  
  
  RESULTS
  There were no significant differences in the distribution of MIF -173G/C genotypes, alleles or carriage rates between case and control groups in either populations. However, the GG genotype of the MIF SNP rs1007888 was associated with MI in Czech female patients (p=0.027).
  
  
  CONCLUSIONS
  Taken together with previous reports, our study suggests that particular MIF gene polymorphisms may contribute to MI susceptibility in females.
authors.affiliation: Russian Acad. Medical Science-Siberian branch, Novosibirsk, Russian Federation.
authors.forename: Irina P
authors.initials: IP
authors.lastname: Tereshchenko
authors.forename: Jana
authors.initials: J
authors.lastname: Petrkova
authors.forename: Frantisek
authors.initials: F
authors.lastname: Mrazek
authors.forename: Jan
authors.initials: J
authors.lastname: Lukl
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Maksimov
authors.forename: Aida G
authors.initials: AG
authors.lastname: Romaschenko
authors.forename: Mikhail I
authors.initials: MI
authors.lastname: Voevoda
authors.forename: Martin
authors.initials: M
authors.lastname: Petrek
mesh_terms: D000328:Adult; D000483:Alleles; D018153:Czech Republic / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000235:genetics*; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D012426:Russia / Q000453:epidemiology; D012737:Sex Factors
chemical_list: D008263:Macrophage Migration-Inhibitory Factors; D019746:Intramolecular Oxidoreductases; C515598:MIF protein, human