title: Regulation of airway innate and adaptive immune responses: the IL-17 paradigm.
abstract: IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along with the well-established Th1/Th2 model, new discoveries regarding the Th17 lineage and IL-17 functions have added an extra twist to the already complicated cytokine network that regulates airway immunity. The IL-17 receptor is expressed on blood cells, as well as on structural cells such as the epithelial cells in the airway. Therefore, the effect of IL-17 on airway immunity is very broad, covering both the innate and the adaptive aspects. In this review, we summarize the findings of recent studies on IL-17 signaling and function in pulmonary immune response, and the implications of IL-17 in disease pathogenesis.
authors.affiliation: Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USA.
authors.forename: Li-Yin
authors.initials: LY
authors.lastname: Hung
authors.forename: Sharlene
authors.initials: S
authors.lastname: Velichko
authors.forename: Fei
authors.initials: F
authors.lastname: Huang
authors.forename: Philip
authors.initials: P
authors.lastname: Thai
authors.forename: Reen
authors.initials: R
authors.lastname: Wu
mesh_terms: D000818:Animals; D001249:Asthma / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D020381:Interleukin-17 / Q000502:physiology*; D008168:Lung / Q000276:immunology*; D053722:Receptors, Interleukin-17 / Q000032:analysis / Q000502:physiology; D015398:Signal Transduction
chemical_list: D020381:Interleukin-17; D053722:Receptors, Interleukin-17