title: Insulin as an anti-inflammatory and antiatherogenic modulator.
abstract: Data demonstrate the anti-inflammatory effects of insulin and proinflammatory effects of glucose. These data provide a mechanistic justification for the benefits of maintaining euglycemia with insulin infusions in hospitalized patients. Regimens that infuse fixed doses of insulin with high rates of glucose are usually associated with hyperglycemia, which may neutralize the beneficial effects of insulin. Therefore, we propose that such regimens should be avoided and instead replaced by insulin infusions that normalize and maintain blood glucose at a reasonably low level and ensure that plasma insulin is maintained at levels high enough to provide clinically relevant anti-inflammatory and cardioprotective effects. Trials to test this hypothesis are in progress.
authors.affiliation: Kaleida Health, Buffalo, New York, USA. pdandona@kaleidahealth.org
authors.forename: Paresh
authors.initials: P
authors.lastname: Dandona
authors.forename: Ajay
authors.initials: A
authors.lastname: Chaudhuri
authors.forename: Husam
authors.initials: H
authors.lastname: Ghanim
authors.forename: Priya
authors.initials: P
authors.lastname: Mohanty
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology / Q000517:prevention & control*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects*; D048909:Diabetes Complications / Q000517:prevention & control*; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000627:therapeutic use*; D018384:Oxidative Stress
chemical_list: D000893:Anti-Inflammatory Agents; D000924:Anticholesteremic Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin