title: Interest of the attenuation coefficient in multiparametric high frequency ultrasound investigation of whole blood coagulation process.
abstract: Previous studies [R. Libgot, F. Ossant, Y. Gruel, P. Lermusiaux, and F. Patat, Proc.-IEEE Utrason. Symp. 4, 2259-2262 (2005); R. Libgot-Calle, F. Ossant, Y. Gruel, P. Lermusiaux, and F. Patat, Ultrasound Med. Biol. 34, 252-264 (2008); F. Ossant, R. Libgot, P. Coupe, P. Lermusiaux, and F. Patat, Proc.-IEEE Ultrason. Symp. 2, 846-849 (2004)] showed the potential of an in vitro high frequency ultrasound (beyond 20 MHz) device to describe the blood clotting process. The parameters were simultaneously estimated in double transmission (DT) with the calculation of the velocity of longitudinal waves and in backscattering (BS) modes with the estimation of the integrated BS coefficient and the effective scatterer size. The aim of the present study was to show how the integrated attenuation coefficient (IAC) assessed in DT mode could provide additional information on this process, especially regarding the fibrin polymerization which is an important part of the coagulation process. A characteristic time t(a) of the variations in IAC that could be linked to fibrin formation was identified.
authors.affiliation: Universite Francois Rabelais, INSERM U930, CNRS 2448 FRE, Tours, France. rachel.libgot@univ-tours.fr
authors.forename: Rachel
authors.initials: R
authors.lastname: Callé
authors.forename: Camille
authors.initials: C
authors.lastname: Plag
authors.forename: Frédéric
authors.initials: F
authors.lastname: Patat
authors.forename: Frédéric
authors.initials: F
authors.lastname: Ossant
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D004867:Equipment Design; D006801:Humans; D008954:Models, Biological; D014463:Ultrasonography / Q000295:instrumentation