The analgesic and anti-inflammatory activities of the extract of Albizia lebbeck in animal model.
The extract of the bark of Albizia lebbeck Benth. obtained by cold extraction of mixture of equal proportions of petroleum ether, ethyl acetate and methanol was chosen for pharmacological screening. In rat paw edema model induced by carrageenan, the extract at the 400 mg/kg dose level showed 36.68% (p<0.001) inhibition of edema volume at the end of 4h. In the acetic acid-induced writhing test, the extract at the 200 and 400 mg/kg dose level showed 39.9% and 52.4 % inhibition of writhing, respectively. In radiant heat tail-flick method the crude extract produced 40.74% (p<0.001) and 61.48% (p<0.001) elongation of tail flicking time 30 minutes after oral administration at the 200 and 400 mg/kg dose level, respectively.
Saha
Achinto
A
Department of Clinical Pharmacy and Pharmacology, University of Dhaka, Dhaka-1000, Bangladesh. achintosaha@yahoo.com
Ahmed
Muniruddin
M
D019342:Acetic Acid; D000284:Administration, Oral; D031289:Albizzia; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002351:Carrageenan; D004195:Disease Models, Animal; D006358:Hot Temperature; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D020318:Rats, Long-Evans
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid