Mucor circinelloides as a cause of invasive maxillofacial zygomycosis: an emerging dimorphic pathogen with reduced susceptibility to posaconazole.
A case of maxillofacial zygomycosis caused by Mucor circinelloides, identified by phenotypic and molecular methods and treated successfully with liposomal amphotericin B (AmBisome) and surgical debridement, is described. The isolate was resistant to posaconazole. This report underscores the importance of prior susceptibility testing of zygomycetes to guide therapy with the most effective antifungal agent for an improved prognosis.
Khan
Zia U
ZU
Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait. zkhan@hsc.edu.kw
Ahmad
Suhail
S
Brazda
Arnost
A
Chandy
Rachel
R
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D025141:Drug Resistance, Fungal; D006801:Humans; D008297:Male; D008439:Maxillary Diseases / Q000188:drug therapy / Q000209:etiology*; D008969:Molecular Sequence Data; D009089:Mucor / Q000187:drug effects / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D014230:Triazoles / Q000494:pharmacology*; D020096:Zygomycosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology
D000935:Antifungal Agents; D004271:DNA, Fungal; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B