title: Comparison of florfenicol and tulathromycin for the treatment of undifferentiated fever in Alberta feedlot calves.
abstract: The purpose of this study was to compare the efficacy and cost-effectiveness of florfenicol versus tulathromycin for initial treatment of undifferentiated fever in fall-placed steer calves that received metaphylactic tilmicosin on arrival at the feedlot. No significant differences (P > .10) were observed in undifferentiated fever relapses or the crude case fatality rate. Calves treated with florfenicol had a lower case fatality rate (P = .04) for bovine respiratory disease and Histophilus disease than did calves treated with tulathromycin. The net economic advantage of florfenicol over tulathromycin (Can$17.70/treated animal) was based on differences in costs for the trial drug and calf replacement owing to bovine respiratory disease and Histophilus disease case fatality.
authors.affiliation: Alberta Beef Health Solutions Inc, Picture Butte, Alberta, Canada. donkersg@telus.net
authors.forename: Joyce
authors.initials: J
authors.lastname: Van Donkersgoed
authors.forename: Janice
authors.initials: J
authors.lastname: Berg
authors.forename: Steven
authors.initials: S
authors.lastname: Hendrick
mesh_terms: D000416:Alberta / Q000453:epidemiology; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000191:economics / Q000494:pharmacology*; D048090:Bovine Respiratory Disease Complex / Q000188:drug therapy* / Q000401:mortality; D002417:Cattle; D003362:Cost-Benefit Analysis; D004187:Disaccharides / Q000191:economics / Q000494:pharmacology*; D006571:Heterocyclic Compounds / Q000191:economics / Q000494:pharmacology*; D008297:Male; D011897:Random Allocation; D012307:Risk Factors; D013839:Thiamphenicol / Q000031:analogs & derivatives* / Q000191:economics / Q000494:pharmacology; D016896:Treatment Outcome; D018942:Macrolides
chemical_list: D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006571:Heterocyclic Compounds; D013839:Thiamphenicol; C035534:florfenicol; C485204:tulathromycin; D018942:Macrolides