Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease.
OBJECTIVE
The polymorphism (rs1800587) in the 5'-flanking regulatory region at -889 of the interleukin-1alpha gene has been shown to be associated with inflammatory diseases and Alzheimer's disease (AD). The aim of the current study is to determine whether there is an association between the promoter region polymorphism of the interleukin-1alpha gene and late-onset AD in a cohort of Turkish patients.


METHODS
One hundred and four subjects with dementia of the Alzheimer type and 103 age-matched controls were genotyped according to the PCR with confronting two-pair primers method.


RESULTS
Although the distribution of genotypes did not significantly differ (p = 0.107), the difference between allelic frequency was nearly significant according to a chi(2) test (p = 0.05) when the controls and patients were compared.


CONCLUSIONS
Our results showed that there is no association between the -889 C/T transition on the interleukin-1alpha gene and late-onset AD in the Turkish population.
Dursun
Erdinç
E
Department of Medical Biology, Cerrahpasa Faculty of Medicine, Istanbul University, Istanbul, Turkey.
Gezen-Ak
Duygu
D
Ertan
Turan
T
Bilgiç
Başar
B
Gürvit
Hakan
H
Emre
Murat
M
Eker
Engin
E
Engin
Funda
F
Uysal
Omer
O
Yilmazer
Selma
S
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014421:Turkey / Q000453:epidemiology
D017931:DNA Primers; D053582:Interleukin-1alpha; D004247:DNA