Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod.
Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.
Erkek
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Department of Dermatology, Yeditepe University School of Medicine, Istanbul, Turkey. emelerkek@hotmail.com
Basar
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H
Bozdogan
O
O
Emeksiz
M C
MC
D017255:Acitretin / Q000627:therapeutic use*; D000284:Administration, Oral; D000287:Administration, Topical; D000634:Aminoquinolines / Q000627:therapeutic use*; D003131:Combined Modality Therapy / Q000379:methods; D003218:Condylomata Acuminata / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D004359:Drug Therapy, Combination; D006801:Humans; D000077271:Imiquimod; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010409:Penile Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*
D000634:Aminoquinolines; D007641:Keratolytic Agents; D017255:Acitretin; D000077271:Imiquimod