Near-IR remote release from assemblies of liposomes and nanoparticles.
Set free by light: Near-IR (NIR) laser-initiated remote release of fluorescent dye from complexes of liposome-gold-nanoparticle aggregates is demonstrated (see fluorescence images). Complexes of the desired size are shown to be a viable approach to the construction of vesicle-based drug-delivery systems with light-triggered remote release characteristics. This opens up a new method to manipulate liposome-based drug-delivery systems in a biocompatible way by using the near-IR spectral range.
Volodkin
Dmitry V
DV
Department of Interfaces, Max Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14424 Golm/Potsdam, Germany. dmitry.volodkin@mpikg.mpg.de
Skirtach
Andre G
AG
Möhwald
Helmuth
H
D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods; D005456:Fluorescent Dyes / Q000737:chemistry / Q000528:radiation effects; D006046:Gold / Q000737:chemistry*; D007834:Lasers; D008081:Liposomes / Q000737:chemistry* / Q000528:radiation effects; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission
D004337:Drug Carriers; D005456:Fluorescent Dyes; D008081:Liposomes; D006046:Gold