title: An approach to thermodynamically controlled supramolecular assembly possessing an integral locking mechanism.
abstract: A general approach for thermodynamically controlled molecular assembly employing carbonyl addition chemistry is exemplified with a prototypical rotaxane synthesis. Recognition-driven assembly of the rotaxane proceeds under conditions of mild base catalysis, while subsequent treatment with catalytic acid triggers a dehydrative locking mechanism and fixes the evolved molecular architecture in place.
authors.affiliation: Department of Chemistry, Mount Holyoke College, South Hadley, Massachusetts 01075, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Cagulada
authors.forename: Darren G
authors.initials: DG
authors.lastname: Hamilton