Effects of yokukansan, a traditional Japanese medicine, on aggressiveness induced by intracerebroventricular injection of amyloid beta protein into mice.
The effects of yokukansan, a traditional Japanese medicine, on aggressiveness and motor activities were examined in mice after injection of amyloid beta protein (Abeta) into the lateral ventricle of the brain. The results were compared with those of conventional (haloperidol) and atypical (risperidone) antipsychotic medicines. A significant increase in aggressiveness was observed on day 7 after injection of Abeta, and it lasted until day 28. A single oral administration of yokukansan (1.0 g/kg) did not ameliorate the aggressiveness observed on day 7. However, a tendency toward amelioration of the aggressiveness was observed after the administration of yokukansan (0.5 and 1.0 g/kg) for 1 week (days 7-14). The 3 week administration (days 7-28) of yokukansan significantly ameliorated the aggressiveness in a dose-dependent manner without inhibition of motor activity. In contrast, a single administration of intraperitoneal haloperidol (0.03-0.1 mg/kg) or oral risperidone (0.1-0.3 mg/kg) on day 28 significantly reduced aggressiveness in a dose-dependent manner. However, motor activities were significantly suppressed. These results suggest yokukansan reduces aggressiveness without suppressing physical activity.
Sekiguchi
Kyoji
K
Tsumura Research Laboratories, Tsumura & Co. 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300-1192, Japan. sekiguchi_kyouji@mail.tsumura.co.jp
Yamaguchi
Takuji
T
Tabuchi
Masahiro
M
Ikarashi
Yasushi
Y
Kase
Yoshio
Y
D000374:Aggression / Q000187:drug effects*; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018967:Risperidone / Q000494:pharmacology
D016229:Amyloid beta-Peptides; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C524644:Yi-Gan San; D006220:Haloperidol; D018967:Risperidone