title: Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
abstract: We identified a marker in LINGO1 showing genome-wide significant association (P = 1.2 x 10(-9), odds ratio = 1.55) with essential tremor. LINGO1 has potent, negative regulatory influences on neuronal survival and is also important in regulating both central-nervous-system axon regeneration and oligodendrocyte maturation. Increased axon integrity observed in Lingo1 mouse [corrected] knockout models highlights the potential role of LINGO1 in the pathophysiology of ET [corrected]
authors.affiliation: deCODE genetics, Sturlugata 8, IS-101 Reykjavík, Iceland.
authors.forename: Hreinn
authors.initials: H
authors.lastname: Stefansson
authors.forename: Stacy
authors.initials: S
authors.lastname: Steinberg
authors.forename: Hjorvar
authors.initials: H
authors.lastname: Petursson
authors.forename: Omar
authors.initials: O
authors.lastname: Gustafsson
authors.forename: Iris H
authors.initials: IH
authors.lastname: Gudjonsdottir
authors.forename: Gudrun A
authors.initials: GA
authors.lastname: Jonsdottir
authors.forename: Stefan T
authors.initials: ST
authors.lastname: Palsson
authors.forename: Thorlakur
authors.initials: T
authors.lastname: Jonsson
authors.forename: Jona
authors.initials: J
authors.lastname: Saemundsdottir
authors.forename: Gyda
authors.initials: G
authors.lastname: Bjornsdottir
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Böttcher
authors.forename: Theodora
authors.initials: T
authors.lastname: Thorlacius
authors.forename: Dietrich
authors.initials: D
authors.lastname: Haubenberger
authors.forename: Alexander
authors.initials: A
authors.lastname: Zimprich
authors.forename: Eduard
authors.initials: E
authors.lastname: Auff
authors.forename: Christoph
authors.initials: C
authors.lastname: Hotzy
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Testa
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Miyatake
authors.forename: Ami R
authors.initials: AR
authors.lastname: Rosen
authors.forename: Kristleifur
authors.initials: K
authors.lastname: Kristleifsson
authors.forename: David
authors.initials: D
authors.lastname: Rye
authors.forename: Friedrich
authors.initials: F
authors.lastname: Asmus
authors.forename: Ludger
authors.initials: L
authors.lastname: Schöls
authors.forename: Martin
authors.initials: M
authors.lastname: Dichgans
authors.forename: Finnbogi
authors.initials: F
authors.lastname: Jakobsson
authors.forename: John
authors.initials: J
authors.lastname: Benedikz
authors.forename: Unnur
authors.initials: U
authors.lastname: Thorsteinsdottir
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gulcher
authors.forename: Augustine
authors.initials: A
authors.lastname: Kong
authors.forename: Kari
authors.initials: K
authors.lastname: Stefansson
mesh_terms: D000818:Animals; D001317:Austria; D020329:Essential Tremor / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D055106:Genome-Wide Association Study; D005858:Germany; D006801:Humans; D007055:Iceland; D015810:Linkage Disequilibrium; D008565:Membrane Proteins / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D012307:Risk Factors; D014481:United States
chemical_list: C482293:LINGO1 protein, human; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins