[Research advancement of optic nerve injury therapy by transgenic expression neurotrophic factors].
Optic nerve injury is one of factors leading to blindness, and the effective therapy is still not available in clinic. The neurotrophic factors (NTF) can significantly enhance the survival of retinal ganglion cells (RGC) and the regeneration of axonal but showed a short-term effect in vivo. The continue expression of NTF by transgenic technology could overcome this disadvantage, which may provide a new therapeutic approach for the optic nerve injury. We reviewed the articles regarding the research progress of transgenic technology in the treatment of optic nerve injure by NTF recently.
Song
De-Lu
DL
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Zhong
Yong
Y
D015316:Genetic Therapy; D006801:Humans; D009414:Nerve Growth Factors / Q000235:genetics* / Q000627:therapeutic use*; D020221:Optic Nerve Injuries / Q000628:therapy*; D019076:Transgenes
D009414:Nerve Growth Factors