Kikuchi-Fujimoto disease.
A 14 year-old Bangladeshi girl presented with high fever, painful swellings in the neck, anorexia, weight loss and night sweating. On examination she had multiple enlarged and tender cervical lymph nodes. Other systems were normal. Laboratory investigations for sepsis and autoimmune diseases were negative. Initial fine needle aspiration and cytology of affected lymph node was suggestive of tubercular lymphdenitis. But she did not respond to anti-tubercular treatment. Kikuchi-Fujimoto disease was diagnosed from the histopathological appearance of excised lymph node. She completely recovered with symptomatic treatment. Kikuchi-Fujimoto disease, also called Kikuchi's disease or histiocytic necrotizing lymphadenitis is a rare, benign but enigmatic disease of unknown aetiology. The disease is self-limited and has an excellent prognosis. Its recognition is crucial because it can be mistaken for systemic lupus erythematosus, malignant lymphoma, tubercular lymphadenitis or even, for metastatic adenocarcinoma. Clinicians' and pathologists' awareness of this disease may help prevent misdiagnosis and inappropriate treatment.
Parveen
R
R
Dhaka Medical College, and Department of Immunology & Molecular Biology, National Institute of Cancer Research & Hospital, Dhaka, Bangladesh.
Rahman
S H
SH
Yasmin
R
R
Quadir
M S
MS
Muazzam
N
N
Alam
M N
MN
D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D011379:Prognosis