[Thyroid-induced hyperthyroidism Yin-deficiency model of rats].
OBJECTIVE
To establish a rat model of hyperthyroidism Yin-deficiency.


METHODS
SD rats separate male and female were randomly divided into four groups, a total of eight groups, each with six. The first group for the control group, 2 to 4 for the experimental drug-treated group, including thyroid-low, medium and high-dose group. In addition to the first group lavage volume of saline, the other groups were given the concentration of 2. 5, 5, 10 mg/kg-saline suspension of the thyroid. Once a day, 30 days for delivery.


RESULTS
Compared with the control group, with the exception of Group 4 female rats serum T3, T4, FT3, FT4 values were significantly higher (P < 0.01), serum TSH was significantly lower (P < 0.05), the other treatment groups had different values no significant difference (P > 0.05). Group 4 that female rats modeling was success.


CONCLUSIONS
Administration of thyroid-Suspension 10 mg/ kg for 30 d, female rats hyperthyroidism Yin-deficiency rat model is success.
Liu
Ting
T
Department of Pharmaceutical, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Hou
Lian-Bing
LB
Hou
Yi-Cheng
YC
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006980:Hyperthyroidism / Q000097:blood / Q000139:chemically induced; D008297:Male; D011863:Radioimmunoassay; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013961:Thyroid Gland / Q000187:drug effects / Q000473:pathology; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000008:administration & dosage*; D014284:Triiodothyronine / Q000097:blood; D016710:Yin Deficiency / Q000097:blood / Q000139:chemically induced
D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine