title: Aurora kinases as prognostic biomarkers in ovarian carcinoma.
abstract: We investigated the expression of Aurora kinases A and B by immunohistochemistry in 68 ovarian carcinomas to analyze their prognostic value. The amplification of AURKA gene by fluorescence in situ hybridization was also assessed. Overall, 58.8% and 85.3% of ovarian carcinomas showed expression of Aurora A and B, respectively. Amplification of AURKA was found in 27.6% of cases examined. Tumors with Aurora A expression showed a lower rate of recurrence than those tumors without Aurora A expression (65% versus 91.7%, P = .019). In the univariate analysis, patients with Aurora A and B expression showed an increased progression-free survival (P = .023 and .06, respectively, log-rank test) and overall survival (P = .03 and .02, respectively, log-rank test). The multivariate analysis adjusted to optimal surgery by Cox proportional hazards regression showed Aurora A expression as an independent prognostic factor for progression-free survival (P = .03) and overall survival (P = .02). In conclusion, Aurora A expression seems to have a prognostic value in ovarian carcinoma.
authors.affiliation: Department of Pathology, Hospital Universitario La Paz, Universidad Autónoma de Madrid, Spain.
authors.forename: Marta
authors.initials: M
authors.lastname: Mendiola
authors.forename: Jorge
authors.initials: J
authors.lastname: Barriuso
authors.forename: Adrián
authors.initials: A
authors.lastname: Mariño-Enríquez
authors.forename: Andrés
authors.initials: A
authors.lastname: Redondo
authors.forename: Aurora
authors.initials: A
authors.lastname: Domínguez-Cáceres
authors.forename: Ginés
authors.initials: G
authors.lastname: Hernández-Cortés
authors.forename: Elia
authors.initials: E
authors.lastname: Pérez-Fernández
authors.forename: Iker
authors.initials: I
authors.lastname: Sánchez-Navarro
authors.forename: Juan Angel Fresno
authors.initials: JA
authors.lastname: Vara
authors.forename: Asunción
authors.initials: A
authors.lastname: Suárez
authors.forename: Enrique
authors.initials: E
authors.lastname: Espinosa
authors.forename: Manuel
authors.initials: M
authors.lastname: González-Barón
authors.forename: José
authors.initials: J
authors.lastname: Palacios
authors.forename: David
authors.initials: D
authors.lastname: Hardisson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D064096:Aurora Kinase A; D064127:Aurora Kinases; D014408:Biomarkers, Tumor / Q000032:analysis*; D004252:DNA Mutational Analysis; D018572:Disease-Free Survival; D005260:Female; D005784:Gene Amplification; D015870:Gene Expression; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000401:mortality; D011379:Prognosis; D017346:Protein Serine-Threonine Kinases / Q000096:biosynthesis* / Q000235:genetics; D046888:Tissue Array Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D016159:Tumor Suppressor Protein p53; C576917:AURKA protein, human; D064096:Aurora Kinase A; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases