title: Peritoneal B-cell subsets in the genus Mus: their role in innate immunity.
abstract: In this review, we demonstrate that wild-derived mouse strains (wild-DMS) represent a useful tool for dissecting the immune system. We confirm and extend the notion that we and others have previously advanced, which is that common laboratory mice are not fully representative of the whole genus Mus. We illustrate how wild-DMS helped us to unveil a novel B-cell population that, in contrast to the B-1 cell population, is present in the entire genus Mus, including common laboratory mice. Moreover, we suggest that Bw cells belong to the "natural memory" B-cell population that comprises B-1 and MZ B cells.
authors.affiliation: Unité de Biologie des Populations Lymphocytaires, Institut Pasteur, Dept. d'Immunologie, CNRS : URA 1961, Paris 75724 Cedex 15, France.
authors.forename: Aude
authors.initials: A
authors.lastname: Thiriot
authors.forename: Antonio A
authors.initials: AA
authors.lastname: Freitas
authors.forename: Dominique
authors.initials: D
authors.lastname: Rueff-Juy
mesh_terms: D000818:Animals; D018941:Antigens, CD19 / Q000032:analysis; D001323:Autoantibodies / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000502:physiology*; D018956:CD5 Antigens / Q000032:analysis; D007113:Immunity, Innate; D016130:Immunophenotyping; D017493:Leukocyte Common Antigens / Q000032:analysis; D051379:Mice / Q000276:immunology*; D010529:Peritoneal Cavity / Q000166:cytology*; D013045:Species Specificity
chemical_list: D018941:Antigens, CD19; D001323:Autoantibodies; D018956:CD5 Antigens; D017493:Leukocyte Common Antigens; C516770:Ptprc protein, mouse