title: Isolation and structure of hematoside-type ganglioside from the starfish Linckia laevigata.
abstract: A hematoside-type ganglioside, LLG-1 (1), has been obtained from the polar lipid fraction of the chloroform/methanol extract of the starfish Linckia laevigata. The structure of the ganglioside has been determined on the basis of chemical and spectroscopic evidence as 1-O-[N-glycolyl-alpha-D-neuraminosyl-(2-->3)-beta-D-galactopyranosyl-(1-->4)-beta-D-glucopyranosyl]-ceramide. The ceramide moiety was composed of heterogeneous 2-hydroxy fatty acid and phytosphingosine units. This is the first report on the isolation and structure elucidation of naked hematoside-type ganglioside from echinoderms.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Inagaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Saito
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Higuchi
mesh_terms: D000818:Animals; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification; D002855:Chromatography, Thin Layer; D005679:G(M3) Ganglioside / Q000737:chemistry* / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D008745:Methylation; D020383:Neutral Glycosphingolipids / Q000737:chemistry* / Q000302:isolation & purification; D013215:Starfish / Q000737:chemistry*; D014020:Tissue Extracts / Q000737:chemistry
chemical_list: D002518:Ceramides; D005679:G(M3) Ganglioside; D020383:Neutral Glycosphingolipids; D014020:Tissue Extracts; C539048:ganglioside LLG-1; D000432:Methanol