Endocrine and ingestive behavioral responses to fluid deprivation in sheep chronically exposed to ethanol.
Endocrine responses to fluid deprivation/restoration and preference for ethanol solution vs. water were assessed in sheep maintained for 5 months on a 10% ethanol solution as their sole source of fluid. Blood pressure, body weight, plasma composition and hormone levels of the alcohol maintained sheep were all within a normal range, except for high plasma concentrations of ANG II and ALDO. During fluid deprivation, AVP concentration increased and fluid-deprived sheep displayed a natriuresis and then a rehydration anti-natriuresis. Sheep did not drink the 10% ethanol solution avidly upon fluid restoration, preferring to drink steadily over the following 24 h; there was an associated increase in blood alcohol concentration (BAC). PRC, ANG II and ALDO all increased throughout the fluid restoration period, whereas plasma AVP and ANP gradually fell. In a separate experiment when water was also supplied to the sheep, they preferred water to 10% ethanol; however, alcohol intake was not eliminated. Overall, this degree of chronic consumption of 10% ethanol solution did not appear to adversely affect physiological mechanisms concerned with body fluid homeostasis after fluid deprivation conditions.
Weisinger
R S
RS
School of Psychological Science, La Trobe University, Victoria 3086, Australia. R.Weisinger@latrobe.edu.au
Begg
D P
DP
Denton
D A
DA
Findlay
A L R
AL
Kennedy
G A
GA
Purcell
B
B
Walker
L L
LL
Blair-West
J R
JR
D000222:Adaptation, Physiological / Q000187:drug effects; D000428:Alcohol Drinking / Q000378:metabolism*; D000450:Aldosterone / Q000097:blood*; D000704:Analysis of Variance; D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D002492:Central Nervous System Depressants / Q000494:pharmacology; D002755:Choice Behavior; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005518:Food Preferences / Q000187:drug effects / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects; D007018:Hypopituitarism; D014868:Water Deprivation / Q000502:physiology*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D002492:Central Nervous System Depressants; D000804:Angiotensin II; D001127:Arginine Vasopressin; D000431:Ethanol; D000450:Aldosterone