title: Molecular mechanisms of MHC class I-antigen processing: redox considerations.
abstract: Major histocompatibility complex (MHC) class I molecules present antigenic peptides to the cell surface for screening by CD8(+) T cells. A number of ER-resident chaperones assist the assembly of peptides onto MHC class I molecules, a process that can be divided into several steps. Early folding of the MHC class I heavy chain is followed by its association with beta(2)-microglobulin (beta(2)m). The MHC class I heavy chain-beta(2)m heterodimer is incorporated into the peptide-loading complex, leading to peptide loading, release of the peptide-filled MHC class I molecules from the peptide-loading complex, and exit of the complete MHC class I complex from the ER. Because proper antigen presentation is vital for normal immune responses, the assembly of MHC class I molecules requires tight regulation. Emerging evidence indicates that thiol-based redox regulation plays critical roles in MHC class I-restricted antigen processing and presentation, establishing an unexpected link between redox biology and antigen processing. We review the influences of redox regulation on antigen processing and presentation. Because redox signaling pathways are a rich source of validated drug targets, newly discovered redox biology-mediated mechanisms of antigen processing may facilitate the development of more selective and therapeutic drugs or vaccines against immune diseases.
authors.affiliation: National Creative Research Center for Antigen Presentation, Department of Biological Sciences, Seoul National University, Seoul, South Korea.
authors.forename: Youngkyun
authors.initials: Y
authors.lastname: Kim
authors.forename: Kwonyoon
authors.initials: K
authors.lastname: Kang
authors.forename: Ilkwon
authors.initials: I
authors.lastname: Kim
authors.forename: Yoon Jeong
authors.initials: YJ
authors.lastname: Lee
authors.forename: Changhoon
authors.initials: C
authors.lastname: Oh
authors.forename: Jeongmin
authors.initials: J
authors.lastname: Ryoo
authors.forename: Eunae
authors.initials: E
authors.lastname: Jeong
authors.forename: Kwangseog
authors.initials: K
authors.lastname: Ahn
mesh_terms: D000818:Animals; D001665:Binding Sites; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D010455:Peptides / Q000378:metabolism; D017510:Protein Folding
chemical_list: D015395:Histocompatibility Antigens Class I; D010455:Peptides