title: [Non-cardiac chest pain and gastroesophageal reflux disease: pathophysiology, diagnostic methods and therapeutic approach].
abstract: BACKGROUND
  Non cardiac chest pain is a frequent symptom in general population. Gastroesophageal reflux disease is the first cause of chest pain without cardiac etiology.
  
  
  OBJECTIVE
  This review aimed to determine the specific mechanisms for esophageal-induced chest pain, to evaluate the results of the available methods of diagnosis, and to precise the therapeutic options in these patients.
  
  
  METHODS
  Literature Review
  
  
  RESULTS
  Gastroesophageal reflux disease is the most frequent etiology of "DTPA".The mechanism of pathogeny is complex. After eliminating coronary disease, diagnosis is based on esophagus ph-metry and markers. Therapeutic test with PPI would be an alternative option to ph-metry. Treatment is based on PPI with appropriate dose and duration. Surgical treatment is indicated only for selected patients.
authors.affiliation: Service de Gastro-entérologie A, Hôpital la Rabta, Tunis.
authors.forename: Sami
authors.initials: S
authors.lastname: Karoui
authors.forename: Jalel
authors.initials: J
authors.lastname: Boubaker
authors.forename: Azza
authors.initials: A
authors.lastname: Filali
mesh_terms: D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D003327:Coronary Disease / Q000175:diagnosis; D003937:Diagnosis, Differential; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018670:Monitoring, Ambulatory; D017410:Practice Guidelines as Topic; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D054328:Proton Pump Inhibitors