Structure elucidation and NMR assignments for three anthraquinone derivatives from the marine fungus Fusarium sp. (No. ZH-210).
The structure elucidations and complete (1)H and (13)C NMR assignments are reported for three new anthraquinone derivatives: Fusaquinon A (1), B (2), and C (3) isolated from the fermentation medium of the marine fungus Fusarium sp. (No. ZH-210). HREIMS, Fourier transform infrared absorption spectrometry (FT-IR), NMR experiments including gCOSY, gHMQC, gHMBC, and NOESY were used for the determination of the structures and NMR spectral assignments. Preliminary pharmacological test showed that they exhibited low cytotoxic activity towards KB, KBv200, and MCF-7 cell lines.
Chen
Yiguang
Y
School of Chemistry and Chemical Engineering, Sun Yat-Sen (Zhongshan) University, Guangzhou 510275, PR China.
Cai
Xiaoling
X
Pan
Jiahui
J
Gao
Junping
J
Li
Jing
J
Yuan
Jie
J
Fu
Liwu
L
She
Zhigang
Z
Lin
Yongcheng
Y
D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005670:Fusarium / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D015394:Molecular Structure; D012015:Reference Standards
C540512:1,4,5,6,7,9-hexahydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one; C540513:1,4,6,7,9-pentahydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one; C540511:1,4,6-trihydroxy-2-methoxy-7-methyl-5,6,8,8a,9,10a-hexahydro-7,9-epoxyanthracen-10-one; D000880:Anthraquinones