The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome.
OBJECTIVE
To investigate the serum and follicular fluid concentrations of insulin resistance parameters and homocysteine and their effect on IVF outcome in nonobese, nonhyperandrogenemic polycystic ovary syndrome patients.


METHODS
Prospective study.


METHODS
Department of Infertility of Dr. Zekai Tahir Burak Women's Health Research and Education Hospital.


METHODS
Ninty-seven women underwent IVF.


METHODS
Subjects were categorized according to IVF indications: group 1 with polycystic ovary syndrome (PCOS), group 2 with subfertile male partners, group 3 with unexplained infertiliy. Serum and follicular fluid parameters from the first follicle on the day of oocyte retrieval were analyzed.


METHODS
Serum and follicular fluid insulin resistance parameters, homocysteine, sex hormone levels, and laboratory and clinical IVF outcome were studied.


RESULTS
Serum insulin, homeostasis model assessment estimate of insulin resistance (HOMA-IR), and homocysteine levels were significantly higher in subjects having PCOS. However, these significant differences in serum insulin resistance and homocysteine levels were not seen in the follicular microenvironment. There were no differences in clinical pregnancy rates between study groups.


CONCLUSIONS
Despite elevated serum insulin, HOMA-IR, and homocysteine levels, and their effects on oocyte numbers and maturation in PCOS patients, there were no differences in follicular parameters and clinical pregnancy rates between hyperinsulinemic and hyperhomocysteinemic PCOS patients and the other two groups.
Nafiye
Yilmaz
Y
Department of Infertility, Dr. Zekai Tahir Burak Women's Health Research and Education Hospital, Ankara, Turkey. nafiyekarakas@hotmail.com
Sevtap
Kilic
K
Muammer
Dogan
D
Emre
Ozgu
O
Senol
Kalyoncu
K
Leyla
Mollamahmutoglu
M
D000328:Adult; D015415:Biomarkers / Q000097:blood* / Q000378:metabolism; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005307:Fertilization in Vitro; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood / Q000150:complications / Q000378:metabolism; D056865:Ideal Body Weight / Q000502:physiology; D007246:Infertility / Q000097:blood / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000378:metabolism; D006080:Ovarian Follicle / Q000737:chemistry / Q000378:metabolism*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D011247:Pregnancy; D011379:Prognosis; D016896:Treatment Outcome; D055815:Young Adult
D015415:Biomarkers; D006710:Homocysteine