title: Sex-dependent effect of cyclooxygenase-2 inhibition on mouse spatial memory.
abstract: Cyclooxygenase (COX)-2 is constitutively expressed in neurons of the hippocampus and neocortex. Therefore, non-steroidal anti-inflammatory drugs (NSAIDs) targeting inflammation-induced COX-2 in the periphery and the central nervous system may also affect cognitive function mediated by basal COX-2 activity. We report that systemic administration of the selective COX-2 inhibitor NS-398 6h prior to behavioral assessment does not influence spatial acquisition or retention in male C57BL/6J mice. However, we observed impaired spatial retention in female mice treated with NS-398, suggesting a sex-dependent role of COX-2 in spatial memory of mice.
authors.affiliation: Department of Biology, Santa Clara University, 500 El Camino Real, Santa Clara, CA 95053, United States.
authors.forename: Cristina B
authors.initials: CB
authors.lastname: Guzmán
authors.forename: Kaylan A
authors.initials: KA
authors.lastname: Graham
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Grace
authors.forename: Amy H
authors.initials: AH
authors.lastname: Moore
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000502:physiology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D005260:Female; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D009578:Nitrobenzenes / Q000494:pharmacology*; D012727:Sex Characteristics; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D016861:Cyclooxygenase Inhibitors; D009578:Nitrobenzenes; D013449:Sulfonamides; C080955:N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide; D051546:Cyclooxygenase 2