title: IFIH1-GCA-KCNH7 locus is not associated with genetic susceptibility to multiple sclerosis in French patients.
abstract: A recent investigation reported, for the first time, an association between variants in the IFIH1-GCA-KCNH7 locus and multiple sclerosis (MS). We sought to replicate this genetic association in MS with a new independent MS cohort composed of French Caucasian MS trio families. The two most significant IFIH1 single nucleotide polymorphisms, rs1990760 and rs2068330, reported as involved in MS susceptibility, were genotyped in 591 French Caucasian MS trio families, and analyzed using the transmission/disequilibrium test. No association with MS was found (rs1990760, P=0.45 and rs2068330, P=0.27). Similarly, no significant association was detected after stratification for HLA-DRB1*1501 carriers. Reasons that may explain this discrepancy between the original report and our study are discussed.
authors.affiliation: INSERM U563, and Pôle des neurosciences, Université Toulouse 3, Toulouse, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Couturier
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Gourraud
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cournu-Rebeix
authors.forename: Claire
authors.initials: C
authors.lastname: Gout
authors.forename: Florence
authors.initials: F
authors.lastname: Bucciarelli
authors.forename: Gilles
authors.initials: G
authors.lastname: Edan
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Babron
authors.forename: Françoise
authors.initials: F
authors.lastname: Clerget-Darpoux
authors.forename: Michel
authors.initials: M
authors.lastname: Clanet
authors.forename: Bertrand
authors.initials: B
authors.lastname: Fontaine
authors.forename: David
authors.initials: D
authors.lastname: Brassat
mesh_terms: D002135:Calcium-Binding Proteins / Q000235:genetics*; D015331:Cohort Studies; D053487:DEAD-box RNA Helicases / Q000235:genetics*; D051638:Ether-A-Go-Go Potassium Channels / Q000235:genetics*; D005602:France; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D000072640:Interferon-Induced Helicase, IFIH1; D009103:Multiple Sclerosis / Q000235:genetics*
chemical_list: D002135:Calcium-Binding Proteins; D051638:Ether-A-Go-Go Potassium Channels; C503121:GCA protein, human; C486376:KCNH7 protein, human; C452815:IFIH1 protein, human; D053487:DEAD-box RNA Helicases; D000072640:Interferon-Induced Helicase, IFIH1