[Association between the TaqI polymorphism of the vitamin D receptor gene and lepromatous leprosy in a Mexican population sample].
OBJECTIVE
To establish the association of the vitamin D receptor gene TaqI polymorphism with lepromatous leprosy (LL) in individuals from Sinaloa, Mexico.


METHODS
A 740 bp fragment was amplified from the VDR gene in DNA samples of 71 patients with LL and 144 controls in the Hospital General de Culiacán during 2004-2007. Polymorphism was identified through TaqI endonuclease.


RESULTS
A significant increase in the genotype TT of the VDR gene was observed in patients when compared to controls (p = 0.040; OR = 1.82).


CONCLUSIONS
Our data support the association between the TT genotype and susceptibility to LL in this Mexican population.
Velarde Félix
Jesús Salvador
JS
Centro de Medicina Genómica, Hospital General de Culiacán Dr. Bernardo J. Gastélum, Culiacán, Sinaloa, México.
Cázarez Salazar
Silvestre Guadalupe
SG
Castro Velázquez
Rafael
R
Rendón Maldonado
José Guadalupe
JG
Rangel Villalobos
Héctor
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015440:Leprosy, Lepromatous / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008800:Mexico / Q000453:epidemiology; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D019914:Taq Polymerase; D055815:Young Adult
D018167:Receptors, Calcitriol; D019914:Taq Polymerase