title: Synthesis and promotion angiogenesis effect of chrysin derivatives coupled to NO donors.
abstract: Two types of new chrysin derivatives were prepared by coupling NO donors of alkyl nitrate and furazan derivatives and were fully characterized by (1)H NMR and other techniques. These compounds were tested in human umbilical vein endothelial cells (HUVECs-12) and all the compounds exhibited cell proliferation. Notable effects of promoting angiogenesis were observed for all the modified compounds using chick chorioallantoic membrane (CAM) assay.
authors.affiliation: Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan, Hunan 411105, PR China.
authors.forename: Sheng-Ming
authors.initials: SM
authors.lastname: Peng
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Zou
authors.forename: Hua-Lan
authors.initials: HL
authors.lastname: Ding
authors.forename: Yong-Lan
authors.initials: YL
authors.lastname: Ding
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Lin
mesh_terms: D043925:Angiogenesis Inducing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply* / Q000378:metabolism; D042783:Endothelial Cells / Q000187:drug effects*; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D009566:Nitrates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020030:Nitric Oxide Donors / Q000737:chemistry / Q000378:metabolism; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014471:Umbilical Veins / Q000166:cytology
chemical_list: D043925:Angiogenesis Inducing Agents; D005419:Flavonoids; D009566:Nitrates; D020030:Nitric Oxide Donors; D010069:Oxadiazoles; C043561:chrysin