Mutational analysis of the WNT gene family in women with Mayer-Rokitansky-Kuster-Hauser syndrome.
The aim of this study is to determine if Müllerian agenesis has a genetic basis linked to the WNT genes. Genomic DNA analyses for mutations in the coding sequences of four members of this family in a series of 11 women with Mayer-Rokitansky-Kuster-Hauser syndrome found four variants in the coding sequence of these genes, but causal mutations were not observed. This supports the hypothesis that mutations in the coding sequence of WNT4, WNT5A, WNT7A, and WNT9B are not responsible for the Mayer-Rokitansky-Kuster-Hauser syndrome.
Ravel
Celia
C
Human Developmental Genetics, Institut Pasteur, Paris, France.
Lorenço
Diana
D
Dessolle
Lionel
L
Mandelbaum
Jacqueline
J
McElreavey
Ken
K
Darai
Emile
E
Siffroi
Jean Pierre
JP
D000568:Amenorrhea / Q000235:genetics*; D004252:DNA Mutational Analysis; D005187:Fallopian Tubes / Q000002:abnormalities*; D005260:Female; D006801:Humans; D009095:Mullerian Ducts / Q000002:abnormalities*; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D013577:Syndrome; D014599:Uterus / Q000002:abnormalities*; D014621:Vagina / Q000002:abnormalities*; D051153:Wnt Proteins / Q000235:genetics*; D000071818:Wnt-5a Protein; D060528:Wnt4 Protein
D011518:Proto-Oncogene Proteins; C555581:WNT4 protein, human; C085389:WNT5A protein, human; C092778:WNT7A protein, human; C449090:WNT9B protein, human; D051153:Wnt Proteins; D000071818:Wnt-5a Protein; D060528:Wnt4 Protein