title: Published international classification of retinoblastoma (ICRB) definitions contain inconsistencies--an analysis of impact.
abstract: OBJECTIVE
  To determine the impact of subtle differences (most notably in their classification of group E eyes) in two published versions of the ICRB (Philadelphia and the Children's Hospital Los Angeles).
  
  
  METHODS
  Analysis of a series of 96 eyes with intra-ocular retinoblastoma.
  
  
  RESULTS
  The disparate criteria of the 2 published ICRB schemas affected group assignment of 5.2% of the eyes (25% of the group E eyes).
  
  
  CONCLUSIONS
  Discrepancies need to be reconciled to ensure accurate and uniform application of the ICRB.
authors.affiliation: Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Novetsky
authors.forename: David H
authors.initials: DH
authors.lastname: Abramson
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Kim
authors.forename: Ira J
authors.initials: IJ
authors.lastname: Dunkel
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016190:Carboplatin / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D038801:International Classification of Diseases / Q000592:standards*; D011642:Publications / Q000592:standards; D019572:Retinal Neoplasms / Q000145:classification* / Q000188:drug therapy / Q000401:mortality; D012175:Retinoblastoma / Q000145:classification* / Q000188:drug therapy / Q000401:mortality; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin