Provocation of silence.
We describe the development of a Brugada ECG together with sinus- and ventricular arrest after intravenous flecainide for atrial fibrillation in a patient in whom eventually a SCN5a mutation was identified. Unrecognized SCN5A mutations could underlie class IC-induced sinus arrest and conduction defects in some patients.
van Opstal
Jurren M
JM
Department of Cardiology, Maastricht University Medical Centre, P. Debyelaan 25, PO Box 5800, 6202 AZ Maastricht, The Netherlands. jmvanopstal@yahoo.com
Volders
Paul G A
PG
Crijns
Harry J G M
HJ
D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000235:genetics*; D053840:Brugada Syndrome / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics*; D062554:NAV1.5 Voltage-Gated Sodium Channel; D015222:Sodium Channels / Q000235:genetics*
D009124:Muscle Proteins; D062554:NAV1.5 Voltage-Gated Sodium Channel; C568320:SCN5A protein, human; D015222:Sodium Channels