The molecular programme of tumour reversion: the steps beyond malignant transformation.
How cells become malignant has preoccupied scientists for over a century. However, the converse question is also valid: are tumour cells capable of reverting from their malignant state? Askanazy's studies in 1907 indicated that teratoma cells could differentiate into normal somatic tissues and current evidence indicates that some tumour cells have acquired the molecular circuitry that results in the negation of chromosomal instability, translocations, oncogene activation and loss of tumour suppressor genes. Studying these extremely rare events of tumour reversion and deciphering these pathways, which involve SIAH1, presenilin 1, TSAP6 and translationally controlled tumour protein (TCTP), could lead to new avenues in cancer treatment.
Telerman
Adam
A
LBPA, UMR 8113, Ecole Normale Supérieure, 61 Avenue du Président Wilson, 94235 Cachan, France. adam.telerman@lbpa.ens-cachan.fr
Amson
Robert
R
D000818:Animals; D014408:Biomarkers, Tumor / Q000502:physiology; D018797:Cell Cycle Proteins; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics*; D009687:Nuclear Proteins / Q000502:physiology; D015513:Oncogene Proteins / Q000502:physiology; D010088:Oxidoreductases; D053764:Presenilin-1 / Q000502:physiology; D000090324:Tumor Protein, Translationally-Controlled 1; D044767:Ubiquitin-Protein Ligases / Q000502:physiology; D000098563:Seven in Absentia Proteins
D014408:Biomarkers, Tumor; D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D053764:Presenilin-1; C000715647:TPT1 protein, human; D000090324:Tumor Protein, Translationally-Controlled 1; D010088:Oxidoreductases; C486677:STEAP3 protein, human; D044767:Ubiquitin-Protein Ligases; D000098563:Seven in Absentia Proteins