title: Antibacterial effect of octylcyanoacrylate against methicillin-resistant Staphylococcus aureus isolates from patients with chronic suppurative otitis media.
abstract: There has been a steady increase in the number of cases of methicillin-resistant Staphylococcus aureus (MRSA) otorrhea; this is a growing medical concern. For otological surgery in children, octylcyanoacrylate can be an alternative method of closure for surgical incisions. Recent in vitro studies have shown that octylcyanoacrylate is effective as an antimicrobical barrier. To date, there have been only rare reports on the antibacterial effect of octylcyanoacrylate against MRSA. The purpose of this study is to determine the antimicrobial effects of octylcyanoacrylate against the MRSA that was isolated from patients with chronic suppurative otitis media.
  
  
  METHODS
  Clinical MRSA (n=20) bacteria and methicillin-sensitive SA (MSSA) (n=20) were obtained from patients. The susceptibilities to various antibiotics were determined by disk diffusion method.
  
  
  RESULTS
  MSSA was sensitive to octylcyanoacrylate. The antibacterial activity of octylcyanoacrylate was weak against MRSA.
  
  
  CONCLUSIONS
  Our results demonstrated that octylcyanoacrylate has slight antibacterial activity against MRSA.
authors.affiliation: Department of Otolaryngology, Chonnam National University Medical School, Gwangju, South Korea. chulsavio@hanmail.net
authors.forename: Chul Ho
authors.initials: CH
authors.lastname: Jang
authors.forename: Haekyun
authors.initials: H
authors.lastname: Park
authors.forename: Cheol Hee
authors.initials: CH
authors.lastname: Choi
authors.forename: Yong Bum
authors.initials: YB
authors.lastname: Cho
authors.forename: Il Yong
authors.initials: IY
authors.lastname: Park
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D003487:Cyanoacrylates / Q000627:therapeutic use*; D006801:Humans; D016106:Methicillin Resistance; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010034:Otitis Media with Effusion / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D003487:Cyanoacrylates; C119247:octylcyanoacrylate