A biomimetic electrocatalytic system for the atom-economical chemoselective synthesis of secondary amines.
A facile one-pot oxidation-imine formation-reduction route to secondary amines can be achieved electrolytically from primary amines. This atom-economical 1(ox)-mediated sequence, leaving ammonia as the sole byproduct, allows the rapid chemoselective synthesis of secondary amines, at both ambient temperature and pressure.
Largeron
Martine
M
UMR 8638 Synthese et Structure de Molecules d'Interet Pharmacologique, CNRS-Universite Paris Descartes, 4 avenue de l'observatoire, 75270 Paris cedex 06, France. martine.largeron@parisdescartes.fr
Fleury
Maurice-Bernard
MB
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D000641:Ammonia / Q000032:analysis; D040761:Biomimetic Materials / Q000737:chemistry*; D032701:Biomimetics; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D007097:Imines / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
D000588:Amines; D007097:Imines; D000641:Ammonia