The emerging role of miR-200 family of microRNAs in epithelial-mesenchymal transition and cancer metastasis.
MicroRNAs (miRNAs) play essential roles in many physiological and pathological processes, including tumor development, by regulating the expression of a plethora of mRNAs. Although the importance of miRNAs in tumorigenesis is well established, only recently have reports elucidated miRNAs as promoters or suppressors of metastasis. The miR-200 family has been shown to inhibit the initiating step of metastasis, epithelial-mesenchymal transition (EMT), by maintaining the epithelial phenotype through direct targeting of transcriptional repressors of E-cadherin, ZEB1 and ZEB2. These findings shed light into a miRNA-mediated regulatory pathway that influences EMT in a developmentally and pathologically relevant setting.
Korpal
Manav
M
Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.
Kang
Yibin
Y
D000818:Animals; D004848:Epithelium / Q000473:pathology*; D006801:Humans; D008648:Mesoderm / Q000473:pathology*; D035683:MicroRNAs / Q000378:metabolism*; D009362:Neoplasm Metastasis / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism
D035683:MicroRNAs; D014157:Transcription Factors