Synthesis and antimicrobial activity of some new pyrazole derivatives containing a ferrocene unit.
A series of new imines and amines have been synthesized by condensation of 1H-3-ferrocenyl-1-phenylpyrazole-4-carboxaldehyde with the corresponding amines, followed by reduction with sodium borohydride. The synthesized compounds have been screened for their in vitro antimicrobial activity against 11 bacteria and three fungal/yeast strains, using disc diffusion and broth microdilution susceptibility assays. They have shown a wide range of activities, from completely inactive to the highly active compounds.
Damljanović
Ivan
I
University of Kragujevac, Faculty of Science, Department of Chemistry, R. Domanovića 12, 34000 Kragujevac, Serbia.
Vukićević
Mirjana
M
Radulović
Niko
N
Palić
Radosav
R
Ellmerer
Ernst
E
Ratković
Zoran
Z
Joksović
Milan D
MD
Vukićević
Rastko D
RD
D000588:Amines / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002738:Chloroquine / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D004351:Drug Resistance / Q000187:drug effects; D005296:Ferrous Compounds / Q000737:chemistry*; D005658:Fungi / Q000187:drug effects; D007097:Imines / Q000494:pharmacology; D000075163:Metallocenes; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000588:Amines; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005296:Ferrous Compounds; D007097:Imines; D000075163:Metallocenes; D011720:Pyrazoles; D002738:Chloroquine; C004998:ferrocene