title: Radioiodine therapy for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases.
abstract: BACKGROUND
  Differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases has been observed in follow-up studies. The management of this condition remains controversial. Most studies support blind radioactive iodine treatment while others negate this approach.
  
  
  OBJECTIVE
  To assess the effects of radioiodine therapy for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases.
  
  
  METHODS
  Studies were obtained from computerised searches of MEDLINE, EMBASE, The Cochrane Library, China National Infrastructure (CNKI) and paper collections of conferences held in Chinese.
  
  
  METHODS
  Randomised controlled clinical trials and prospective controlled clinical trials.
  
  
  METHODS
  Two authors independently extracted data and interviewed authors of all potentially relevant studies by electronic mail to verify randomisation procedures. One author entered data into a data extraction form and the second one verified the results of this procedure.
  
  
  RESULTS
  Because of the absence of any suitable randomised or prospective controlled trial in this area, results currently cannot be presented.
  
  
  CONCLUSIONS
  The currently available evidence is insufficient to reliably assess the potential of radioiodine treatment for differentiated thyroid carcinoma with thyroglobulin positive and radioactive iodine negative metastases.
authors.affiliation: Department of Nuclear Medicine, Affiliated Hospital of Medical College Qingdao University, Jiangsu Road 16, Qingdao, Shandong Province, China, 266003. machaopony@hotmail.com
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.forename: Anren
authors.initials: A
authors.lastname: Kuang
authors.forename: Jiawei
authors.initials: J
authors.lastname: Xie
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D013954:Thyroglobulin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood / Q000532:radiotherapy*
chemical_list: D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D013954:Thyroglobulin