Renal manifestations of the antiphospholipid syndrome.
The antiphospholipid syndrome is characterized by recurrent arterial and venous thromboses and pregnancy morbidity in association with antiphospholipid antibodies. Recurrent thrombotic events are associated with significant morbidity and mortality. Renal involvement encompasses the whole renal vasculature and may lead to proteinuria, renal impairment, hypertension, and end-stage renal failure. Renal involvement is especially difficult to distinguish from glomerulonephritis when the antiphospholipid syndrome develops in patients with systemic lupus erythematosus. This article reviews the diagnosis and treatment of the major features of this syndrome, with particular reference to the kidney.
D'Cruz
David
D
The Lupus Research Unit, The Rayne Institute, St Thomas' Hospital, London, United Kingdom. david.d'cruz@kcl.ac.uk
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000098:blood supply / Q000473:pathology*; D007674:Kidney Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000473:pathology; D016030:Kidney Transplantation; D011247:Pregnancy; D013927:Thrombosis / Q000473:pathology*; D055815:Young Adult
D000925:Anticoagulants; D007166:Immunosuppressive Agents