Receptor-mediated targeting of cathepsins in professional antigen presenting cells.
Tag for professionals: A fluorescently tagged clustered mannoside DCG-04 analogue (see structure) is designed and synthesized using a modular approach. Uptake of the probe in professional antigen presenting cells and subsequent labeling of cathepsins proceeded in a mannose-receptor dependent manner.
Hillaert
Ulrik
U
Leiden Institute of Chemistry, Leiden University, P.O. Box 9052, 2300 RA Leiden, The Netherlands.
Verdoes
Martijn
M
Florea
Bogdan I
BI
Saragliadis
Athanasios
A
Saragliadis
Anastasios
A
Habets
Kim L L
KL
Kuiper
Johan
J
Van Calenbergh
Serge
S
Ossendorp
Ferry
F
van der Marel
Gijsbert A
GA
Driessen
Christoph
C
Overkleeft
Hermen S
HS
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002403:Cathepsins / Q000378:metabolism*; D002478:Cells, Cultured; D037181:Lectins, C-Type / Q000378:metabolism; D007930:Leucine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism; D051381:Rats; D011956:Receptors, Cell Surface / Q000378:metabolism
C419228:DCG 04; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D011956:Receptors, Cell Surface; D002403:Cathepsins; D007930:Leucine