A quinoline antibiotic from Rhodococcus erythropolis JCM 6824.
A new quinoline antibiotic, aurachin RE, was isolated and identified from a culture broth of Rhodococcus erythropolis JCM 6824. The aurachin RE structure was determined based on NMR and mass spectrometric analysis. The structure is similar to that of aurachin C antibiotics that have been identified from Stigmatella aurantiaca. Compared to aurachin C, however, aurachin RE exhibits a wide and strong antimicrobial spectrum against both high- and low-GC Gram-positive bacteria.
Kitagawa
Wataru
W
Research Institute of Genome-based Biofactory, National Institute of Advanced Industrial Science and Technology (AIST).
Tamura
Tomohiro
T
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003470:Culture Media / Q000737:chemistry*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006898:Hydroxylamines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D015363:Quinolones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D012240:Rhodococcus / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D006898:Hydroxylamines; D015363:Quinolones; C540754:aurachin RE