title: Lack of association between interleukin-1 alpha rs1800587 polymorphism and Alzheimer's disease in two Independent European samples.
abstract: Interleukin-1 (IL1) can contribute to pathophysiology of Alzheimer's disease (AD) by promoting deposition of amyloid-beta in the brain. The gene encoding IL1 alpha (IL1A) has a common polymorphism in its 5' regulatory region (rs1800587) with possible functional effects. IL1A T/T genotype has been associated with AD but the overall effect is modest and negative studies have been published. The aim of this study was to investigate the association of the IL1A rs1800587 polymorphism with AD in two independent case-control groups from Greece (Athens) and Italy (Faenza and Granarolo). Preliminary results from the ongoing sample (110 patients with sporadic AD and 130 nonpsychiatric controls) showed no association between IL1A variants and AD, however C/T heterozygotes had more severe depression in AD (Cornell Scale for Depression in Dementia) compared to other genotypes (F = 4.56, d.f = 1, p = 0.037) after controlling for age, illness duration and cognitive impairment (MMSE). Despite the small sample size and the possibility of a false negative finding, our preliminary data support the hypothesis the IL1A rs1800587 variants are not associated with AD. The effect of the IL1A on depressive symptomatology warrants further investigations, however the lack of a gene-dose relationship would suggest a false positive.
authors.affiliation: Institute of Psychiatry, University of Bologna, Bologna, Italy. alessandro.serretti@unibo.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Paolo
authors.initials: P
authors.lastname: Olgiati
authors.forename: Antonis
authors.initials: A
authors.lastname: Politis
authors.forename: Petros
authors.initials: P
authors.lastname: Malitas
authors.forename: Diego
authors.initials: D
authors.lastname: Albani
authors.forename: Sabrina
authors.initials: S
authors.lastname: Dusi
authors.forename: Letizia
authors.initials: L
authors.lastname: Polito
authors.forename: Stefania
authors.initials: S
authors.lastname: De Mauro
authors.forename: Aikaterini
authors.initials: A
authors.lastname: Zisaki
authors.forename: Christina
authors.initials: C
authors.lastname: Piperi
authors.forename: Ioannis
authors.initials: I
authors.lastname: Liappas
authors.forename: Evangelia
authors.initials: E
authors.lastname: Stamouli
authors.forename: Antonis
authors.initials: A
authors.lastname: Mailis
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Atti
authors.forename: Monica
authors.initials: M
authors.lastname: Morri
authors.forename: Manjola
authors.initials: M
authors.lastname: Ujkaj
authors.forename: Sara
authors.initials: S
authors.lastname: Batelli
authors.forename: Gianluigi
authors.initials: G
authors.lastname: Forloni
authors.forename: Costantine R
authors.initials: CR
authors.lastname: Soldatos
authors.forename: George N
authors.initials: GN
authors.lastname: Papadimitriou
authors.forename: Diana
authors.initials: D
authors.lastname: De Ronchi
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kalofoutis
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D004493:Education; D005260:Female; D005787:Gene Frequency; D006115:Greece / Q000453:epidemiology; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D007558:Italy / Q000453:epidemiology; D008297:Male; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D001057:Apolipoproteins E; D053582:Interleukin-1alpha; D004247:DNA