title: Risk for depression and neural responses to fearful facial expressions of emotion.
abstract: BACKGROUND
  Depression is associated with neural abnormalities in emotional processing.
  
  
  OBJECTIVE
  This study explored whether these abnormalities underlie risk for depression.
  
  
  METHODS
  We compared the neural responses of volunteers who were at high and low-risk for the development of depression (by virtue of high and low neuroticism scores; high-N group and low-N group respectively) during the presentation of fearful and happy faces using functional magnetic resonance imaging (fMRI).
  
  
  RESULTS
  The high-N group demonstrated linear increases in response in the right fusiform gyrus and left middle temporal gyrus to expressions of increasing fear, whereas the low-N group demonstrated the opposite effect. The high-N group also displayed greater responses in the right amygdala, cerebellum, left middle frontal and bilateral parietal gyri to medium levels of fearful v. happy expressions.
  
  
  CONCLUSIONS
  Risk for depression is associated with enhanced neural responses to fearful facial expressions similar to those observed in acute depression.
authors.affiliation: Department of Experimental Psychology, University of Oxford, Oxford, UK.
authors.forename: Stella W Y
authors.initials: SW
authors.lastname: Chan
authors.forename: Ray
authors.initials: R
authors.lastname: Norbury
authors.forename: Guy M
authors.initials: GM
authors.lastname: Goodwin
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Harmer
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D003866:Depressive Disorder / Q000453:epidemiology* / Q000503:physiopathology; D004644:Emotions / Q000502:physiology*; D005149:Facial Expression; D005239:Fear / Q000523:psychology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D010552:Personality Assessment; D012307:Risk Factors; D055815:Young Adult