Cortical complexity analysis of patients with bipolar disorder using three-dimensional gyrification index.
Bipolar disorder (BD) is a common affective disorder. In morphometric brain imaging studies, BD subjects have atrophic gray matter, especially in the prefrontal area. These structural abnormalities could involve the change of cortical shape. Gyrification index (GI) is a useful metric to measure the degree of cortical complexity. This work aims to compare the cortical development between bipolar patients and healthy controls using GI. No significant difference was detected between two groups. However, we found asymmetry pattern of cortical complexity was increased in limbic lobe on bipolar patients. Significant negative correlation was also observed between rating scores and asymmetry coefficients in frontal lobe.
Liao
Yuan-Lin
YL
Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, Taiwan. yuanlin@vision.csie.ncku.edu.tw
Sun
Yung-Nien
YN
Hsieh
Jen-Chuen
JC
Su
Tung-Ping
TP
Guo
Wan-Yuo
WY
Wu
Yu-Te
YT
D000328:Adult; D000465:Algorithms; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003198:Computer Simulation; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical