[The role of inflammatory factors in pathogenesis of ischemic heart disease].
OBJECTIVE
To study mechanisms of immune derangements in coronary heart disease (CHD).


METHODS
We measured basic markers of immune activation in 43 patients with CHD and NYHA I-IV class heart failure (HF). There were 41 men and 2 women aged 33 - 64 years (mean 48 +/- 8 years). Concentrations of hsCRP, IgA, IgM, IgG were measured using commercially available kits. IL-8, sIL-2R, IL-6, IL-18, IL-10, IFN-gamma endothelin levels were measured using enzyme-linked immunosorbent assay method.


RESULTS
We found evidence of participation of proinflammatory factors in pathogenesis of HF and established associations of mediators of inflammation (CRP, IL-8) with severity of HF, endothelial dysfunction, and impairment of cardiac function.
Tatenkulova
S N
SN
Mareev
V Iu
VIu
Zykov
K A
KA
Belenkov
Iu N
IuN
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D003331:Coronary Vessels / Q000503:physiopathology; D016207:Cytokines / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007136:Immunoglobulins / Q000097:blood*; D007249:Inflammation / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000276:immunology* / Q000503:physiopathology; D014661:Vasoconstriction / Q000502:physiology
D015415:Biomarkers; D016207:Cytokines; D007136:Immunoglobulins; D002097:C-Reactive Protein