title: Surgery for pharmacoresistant epilepsy in the developing world: A pilot study.
abstract: Epilepsy prevalence in the developing world is many fold that found in developed countries. For individuals whose conditions failed to respond to pharmacotherapy, surgery is the only opportunity for cure. In Uganda, we developed a center for treatment of intractable temporal lobe epilepsy (iTLE) that functions within the technologic and expertise constraints of a severely low resource area. Our model relies on partnership with epilepsy professionals and training of local staff. Patients were prescreened at regional clinics for iTLE. Individuals meeting inclusion criteria were referred to the treating Ugandan hospital (CURE Children's' Hospital of Uganda, CCHU) for video-EEG (electroencephalography), computed tomography (CT) imaging, and neuropsychological evaluation. Data were transferred to epilepsy experts for analysis and treatment recommendations. Ten patients were diagnosed with iTLE and surgically treated at CCHU. Six (60%) were seizure free, and there was no neurologic morbidity or mortality. Our model for surgical treatment of pharmacoresistant TLE has functioned successfully in a true developing world low resource setting.
authors.affiliation: Department of Neurosurgery, West Virginia University, Morgantown, West Virginia 26506-9183, USA. wboling@hsc.wvu.edu
authors.forename: Warren
authors.initials: W
authors.lastname: Boling
authors.forename: Adriana
authors.initials: A
authors.lastname: Palade
authors.forename: Angela
authors.initials: A
authors.lastname: Wabulya
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Longoni
authors.forename: Benjamin
authors.initials: B
authors.lastname: Warf
authors.forename: Scott
authors.initials: S
authors.lastname: Nestor
authors.forename: Rubina
authors.initials: R
authors.lastname: Alpitsis
authors.forename: Richard
authors.initials: R
authors.lastname: Bittar
authors.forename: Charles
authors.initials: C
authors.lastname: Howard
authors.forename: Frederick
authors.initials: F
authors.lastname: Andermann
mesh_terms: D000293:Adolescent; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000379:methods*; D010865:Pilot Projects; D014057:Tomography, X-Ray Computed; D014454:Uganda / Q000453:epidemiology; D055815:Young Adult