Circulating CD34+/KDR+ endothelial progenitor cells are reduced in chronic heart failure patients as a function of Type D personality.
The aim of the present study was to assess whether EPC (endothelial progenitor cell) number/function might be an explanatory factor for the observed relationship between Type D personality (a joint tendency towards negative affectivity and social inhibition) and poor cardiovascular prognosis. We also assessed whether the effect of a single exercise bout on EPC number/function was affected by Type D personality. A total of 35 sedentary men with CHF (chronic heart failure; left ventricular ejection fraction <or=45%) underwent CPET (cardiopulmonary exercise testing) and personality assessment with the 14-item Type D scale. CD34+/KDR (kinase insert domain-containing receptor)+ cells were quantified by flow cytometry before and immediately after CPET. Migration of early EPC towards VEGF (vascular endothelial growth factor) and SDF-1alpha (stromal-cell-derived factor-1alpha) was investigated. Type D (n=10) and non-Type D (n=25) patients were comparable with regards to demographics, disease severity and Framingham risk factor score. Circulating EPC numbers were reduced by 54% in Type D compared with non-Type D patients (0.084+/-0.055 and 0.183+/-0.029% of lymphocytes respectively; P=0.006). Exercise led to a 60% increase in EPC in Type D patients, whereas the EPC number remained unchanged in the non-Type D group (P=0.049). Baseline migratory capacity was related to disease severity, but was not different between Type D and non-Type D patients. Exercise induced a highly significant enhancement of migratory capacity in both groups. In conclusion, reduced EPC numbers might explain the impaired cardiovascular outcome in Type D patients. The larger increase in circulating EPCs observed in these patients suggests that acute exercise elicits a more pronounced stimulus for endothelial repair.
Van Craenenbroeck
Emeline M
EM
Department of Cardiology, Antwerp University Hospital, Edegem, Belgium. emeline.vancraenenbroeck@ua.ac.be
Denollet
Johan
J
Paelinck
Bernard P
BP
Beckers
Paul
P
Possemiers
Nadine
N
Hoymans
Vicky Y
VY
Vrints
Christiaan J
CJ
Conraads
Viviane M
VM
D000368:Aged; D018952:Antigens, CD34 / Q000097:blood; D002452:Cell Count; D042783:Endothelial Cells / Q000473:pathology / Q000502:physiology; D004730:Endothelium, Vascular / Q000473:pathology* / Q000503:physiopathology; D015444:Exercise / Q000502:physiology; D005080:Exercise Test / Q000379:methods; D006333:Heart Failure / Q000097:blood / Q000503:physiopathology / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009341:Negativism; D010552:Personality Assessment; D013234:Stem Cells / Q000473:pathology* / Q000502:physiology; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000097:blood
D018952:Antigens, CD34; D040301:Vascular Endothelial Growth Factor Receptor-2