title: Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-beta.
abstract: Bone marrow stromal cells (BMSCs) are strong candidates for cell therapy against human autoimmune diseases. Intravenous administration of syngenic BMSCs to EAMG-model rats effectively ameliorated the disease, partially through a TGF-beta-dependent mechanism. The proliferative ability of T or B cells from EAMG rats was inhibited by BMSCs at proper cocultured ratios. And the imbalance of Th1, Th2, Th17 and Treg cell subsets accompanied with the development of EAMG was corrected by the administration of BMSCs. These results provide further insights into the pathogenesis of MG, EAMG, and other immune-mediated diseases, and support a potential role for BMSCs in their treatment.
authors.affiliation: Department of Neurobiology, Harbin Medical University, Heilongjiang Provincial Key Laboratory of Neurobiology, 157 Bao Jian Road, Harbin 150081, China.
authors.forename: Qing-Fei
authors.initials: QF
authors.lastname: Kong
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Sha-Sha
authors.initials: SS
authors.lastname: Bai
authors.forename: Dong-Xu
authors.initials: DX
authors.lastname: Zhai
authors.forename: Guang-You
authors.initials: GY
authors.lastname: Wang
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Liu
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Sun
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Hai-Sheng
authors.initials: HS
authors.lastname: Peng
authors.forename: Lian-Hong
authors.initials: LH
authors.lastname: Jin
authors.forename: Hu-Lun
authors.initials: HL
authors.lastname: Li
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D001835:Body Weight; D016026:Bone Marrow Transplantation / Q000379:methods*; D049109:Cell Proliferation; D018920:Coculture Techniques / Q000379:methods; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D007136:Immunoglobulins / Q000378:metabolism; D020720:Myasthenia Gravis, Autoimmune, Experimental / Q000276:immunology / Q000601:surgery*; D010455:Peptides / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D011950:Receptors, Cholinergic / Q000276:immunology; D017154:Stromal Cells / Q000276:immunology / Q000637:transplantation*; D006377:T-Lymphocytes, Helper-Inducer / Q000145:classification / Q000276:immunology / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism*; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000276:immunology / Q000378:metabolism*
chemical_list: D016207:Cytokines; D007136:Immunoglobulins; D010455:Peptides; D011950:Receptors, Cholinergic; D016212:Transforming Growth Factor beta