The role of genomics in the neonatal ICU.
Results of both the Human Genome and International HapMap Projects have provided the technology and resources necessary to enable fundamental advances through the study of DNA sequence variation in almost all fields of medicine, including neonatology. Genome-wide association studies are now practical, and the first of these studies are appearing in the literature. This article provides the reader with an overview of the issues in technology and study design relating to genome-wide association studies and summarizes the current state of association studies in neonatal ICU populations with a brief review of the relevant literature. Future recommendations for genomic association studies in neonatal ICU populations are also provided.
Maresso
Karen
K
Section of Genomic Pediatrics, Children's Research Institute, Medical College of Wisconsin, TBRC/CRI, 2nd floor, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA. kmaresso@mcw.edu
Broeckel
Ulrich
U
D015894:Genome, Human; D023281:Genomics; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics*; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000235:genetics; D007363:Intensive Care Units, Neonatal