title: Relationship between serum adipocytokine levels and metabolic syndrome in menopausal women.
abstract: OBJECTIVE
  Adipocytokines are bioactive substances derived from adipose tissues, especially visceral fat, and play a crucial role in the development of metabolic syndrome. The aims of this study were to estimate serum levels of adipocytokines (adiponectin, resistin and TNF-alpha) and to examine the associations between adipocytokine levels and metabolic syndrome in menopausal women.
  
  
  METHODS
  We recruited 28 postmenopausal women with features of metabolic syndrome. For the purpose of comparing adipocytokine levels, 30 postmenopausal women without metabolic syndrome were recruited by matching age and body mass index (BMI). Serum levels of adipocytokines (adiponectin, resistin, TNF-alpha) were then determined, and any potential correlations between adipocytokine levels and metabolic syndrome were investigated.
  
  
  RESULTS
  There were no significant differences in adiponectin or resistin levels in women with metabolic syndrome when compared with the control group. Conversely, TNF-alpha levels were significantly higher in women with metabolic syndrome. Furthermore, multivariate logistic regression analysis indicated that TNF-alpha was significantly associated with metabolic syndrome.
  
  
  CONCLUSIONS
  Our results suggest that, among the adipocytokines (adiponectin, resistin and TNF-alpha), serum TNF-alpha levels may serve as a useful biomarker for diagnosing metabolic syndrome in menopausal women.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Korea University, Anam-dong, Seongbuk-gu, Seoul, Korea.
authors.forename: Hyun Tae
authors.initials: HT
authors.lastname: Park
authors.forename: Soo Hun
authors.initials: SH
authors.lastname: Cho
authors.forename: Geum Joon
authors.initials: GJ
authors.lastname: Cho
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Shin
authors.forename: Soon Cheol
authors.initials: SC
authors.lastname: Hong
authors.forename: Tak
authors.initials: T
authors.lastname: Kim
authors.forename: Jun Young
authors.initials: JY
authors.lastname: Hur
authors.forename: Young Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Sun Haeng
authors.initials: SH
authors.lastname: Kim
mesh_terms: D054392:Adipokines / Q000032:analysis / Q000097:blood*; D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008593:Menopause / Q000097:blood*; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D054392:Adipokines; D007328:Insulin; D014409:Tumor Necrosis Factor-alpha