[Diabetes and autoimmune diseases: prevalence of celiac disease in children and adolescents with type 1 diabetes].
OBJECTIVE
Determine the prevalence of celiac disease in children and adolescents with type 1 diabetes mellitus (DM1) in attendance in Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione (IEDE).


METHODS
Blood samples were analyzed in 120 children and adolescents with DM1 from IEDE Diabetes Clinic for the IgA antitissue-transglutaminase antibody and dosage of the seric IgA. Those with positive serology were guided for upper endoscopy with small-bowel biopsy to confirm the celiac disease.


RESULTS
The antibody was positive in 3 of the 120 patients. The small-bowel biopsy was confirmatory in all of the positive patients, leading to a prevalence of celiac disease of 2.5% in the studied group.


CONCLUSIONS
The prevalence of celiac disease is increased in children and adolescents with DM1 when compared with normality. As most are asymptomatic, it is recommended periodical screening of celiac disease in children with DM1.
Mont-Serrat
Camila
C
Departamento de Diabetes, Instituto Estadual de Diabetes e Endocrinologia Luiz Capriglione, Rio de Janeiro, RJ, Brazil. camserrat@yahoo.com.br
Hoineff
Claudio
C
Meirelles
Ricardo M R
RM
Kupfer
Rosane
R
D000293:Adolescent; D000553:Ambulatory Care; D015415:Biomarkers / Q000097:blood; D001938:Brazil / Q000453:epidemiology; D002446:Celiac Disease / Q000175:diagnosis / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D008403:Mass Screening; D015995:Prevalence; D011503:Transglutaminases / Q000097:blood
D015415:Biomarkers; D007070:Immunoglobulin A; D011503:Transglutaminases