title: Molecular modeling studies of ABC transporters involved in multidrug resistance.
abstract: Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.
authors.affiliation: Department of Pharmacology, Institute of Medical Biology, University of Tromsø, N-9037 Tromsø, Norway. Aina.W.Ravna@fagmed.uit.no
authors.forename: Aina Westrheim
authors.initials: AW
authors.lastname: Ravna
authors.forename: Georg
authors.initials: G
authors.lastname: Sager
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D018432:Drug Resistance, Multiple / Q000235:genetics*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data
chemical_list: D018528:ATP-Binding Cassette Transporters