title: Antioxidant and anticholinesterase activity evaluation of ent-kaurane diterpenoids from Sideritis arguta.
abstract: The petroleum ether and acetone extracts of the aerial parts of Sideritis arguta afforded two new and six known diterpenoids with the ent-kaurane skeleton. The structures of the new diterpenoids were determined as ent-7alpha,18-diacetoxy-16beta-hydroxykaurane (diacetyldistanol) (1) and ent-7alpha-acetoxy,15alpha,18-dihydroxykaur-16-ene (15-epi-eubol) (2) by spectroscopic data interpretation. Antioxidant potential was investigated for the ent-kauranes and the plant extracts by three methods (beta-carotene bleaching, free-radical scavenging, and superoxide-anion scavenging activity). Acetylcholinesterase and butyrylcholinesterase inhibitory activity were also evaluated, and the ent-kauranes eubol (3), sideroxol (5), and 7-epi-candicandiol (6) exhibited moderate butyrylcholinesterase inhibitory activity.
authors.affiliation: Department of Analytical Chemistry, Istanbul University, 34116, Istanbul, Turkey.
authors.forename: Abdülselam
authors.initials: A
authors.lastname: Ertaş
authors.forename: Mehmet
authors.initials: M
authors.lastname: Oztürk
authors.forename: Mehmet
authors.initials: M
authors.lastname: Boğa
authors.forename: Gülaçti
authors.initials: G
authors.lastname: Topçu
mesh_terms: D000975:Antioxidants / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D045786:Diterpenes, Kaurane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D031365:Sideritis / Q000737:chemistry*; D013237:Stereoisomerism; D014421:Turkey
chemical_list: D000975:Antioxidants; D002800:Cholinesterase Inhibitors; D045786:Diterpenes, Kaurane; C548789:ent-7alpha,18-diacetoxy-16beta-hydroxykaurane; C548790:ent-7alpha-acetoxy,15alpha,18-dihydroxykaur-16-ene