Fever of unknown origin in renal transplant patients with tacrolimus.
The immunosuppressive agent tacrolimus is now widely used for the prevention of acute and chronic rejection in renal allograft recipients. We here report on three patients, who developed drug-induced fever due to tacrolimus one to five months after renal transplantation. Extensive search for a focus, autoantibodies and virus infection remained inconclusive. Therefore, drug-induced fever was suggested. After discontinuing tacrolimus and switching to cyclosporine A fever completely resolved within 24 h. This report demonstrates that tacrolimus-induced drug fever should be included in the differential diagnosis of fever of unknown origin in renal transplant recipients.
Hochegger
Kathrin
K
Clinical Division of Nephrology, Innsbruck Medical University, Innsbruck, Austria.
Rudnicki
Michael
M
Auinger
Martin
M
Mark
Walter
W
Margreiter
Raimund
R
Mayer
Gert
G
Rosenkranz
Alexander R
AR
D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D016559:Tacrolimus / Q000009:adverse effects*
D007166:Immunosuppressive Agents; D002097:C-Reactive Protein; D016559:Tacrolimus