[Changes of immunologically-mediated resistance factors after low-intensity longitudinal immunosuppressive effect].
The aim of the article was to determine the effect of intra peritoneal injections of cyclophosphamide on non-specific immunologically mediated resistance. The experiment was conducted on mice. Alternate-day cyclophosphamide was administrated in three dosage schedules: "high" (200 mg/kg), "middle" (20 mg/kg) and "low" (2 mg/kg) for 20 days. The investigation showed that administration of "high" dose cyclophosphamide caused the development of severe depression of non-specific immunologically mediated resistance. Administration of "low" dose cyclophosphamide did not promote non-specific immunologically mediated resistance depression. Moreover administration of "low" dose of CP expressed ability to moderately stimulate non-specific immunologically mediated resistance. However further investigation is needed to study depressive effect of "low" dose cyclophosphamide.
Mamedov
R M
RM
Gamidova
N A
NA
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D007108:Immune Tolerance / Q000187:drug effects* / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D012307:Risk Factors
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide