title: The prevalence of cervical cytology abnormalities and human papillomavirus in women infected with the human immunodeficiency virus.
abstract: BACKGROUND
  The human papillomavirus (HPV) is the major etiologic agent in the development of cervical cancer and its natural history of infection is altered in persons infected with the human immunodeficiency virus (HIV). The prevalence of HPV infection and cervical dysplasia in the HIV sero-positive females in the Bahamas is not known. Finding out the prevalence would allow for the establishment of protocols to optimize total care of this population and help prevent morbidity and mortality related to cervical cancer.
  
  
  OBJECTIVE
  The Objective of this study is to determine the prevalence of high risk HPV genotypes and the prevalence of cervical dysplasia in the HIV sero-positive females attending the Infectious Disease Clinic at the Princess Margaret Hospital, Nassau, Bahamas.
  
  
  METHODS
  One hundred consecutive, consenting, non-pregnant, HIV-sero-positive females from the Infectious Disease Clinic at the Princess Margaret Hospital in Nassau, Bahamas were screened for high-risk HPV infections and cervical cytology abnormalities using liquid-based pap smear and signal amplification nucleic acid method for HPV detection. A questionnaire was also utilized to gather demographic information and obtain information on known risk factors associated with HPV infections such numbers of partners.
  
  
  RESULTS
  The prevalence of high-risk HPV was 67% and cervical abnormalities were noted in 44% of the study population. High-risk HPV types were more likely to be present in women with CD4+ cell counts less than 400 microl-1 and in women with cervical cytology abnormalities (97%). The most common cervical abnormality was low-grade squamous intraepithelial lesions.
  
  
  CONCLUSIONS
  Findings suggest that HIV-sero positive females should have HPV testing done as part of their normal gynecology evaluation and these patients should be encouraged and provisions be made for ease of access having regular PAP smears and HPV testing.
authors.affiliation: Department of Medicine, Princess Margaret Hospital, Nassau, Bahamas. dionne1125@hotmail.com
authors.forename: Dionne N
authors.initials: DN
authors.lastname: Dames
authors.forename: Camille
authors.initials: C
authors.lastname: Ragin
authors.forename: Andrea
authors.initials: A
authors.lastname: Griffith-Bowe
authors.forename: Perry
authors.initials: P
authors.lastname: Gomez
authors.forename: Raleigh
authors.initials: R
authors.lastname: Butler