title: Pars plana vitrectomy, internal limiting membrane peeling, and panretinal endophotocoagulation for macular edema secondary to central retinal vein occlusion.
abstract: OBJECTIVE
  To investigate the visual and anatomic outcomes in eyes with cystoid macular edema (CME) resulting from central retinal vein occlusion (CRVO) that underwent pars plana vitrectomy, internal limiting membrane peeling, and panretinal endolaser photocoagulation (PPV/MP/EL).
  
  
  METHODS
  Retrospective, observational case series.
  
  
  METHODS
  Consecutive, nonrandomized patients at the Duke Eye Center who underwent PPV/MP/EL for treatment of CME secondary to CRVO by a single surgeon (S.F.) over the last 5 years were identified and reviewed. Outcome measures include best-corrected visual acuity (BCVA), foveal thickness, and total macular volume (TMV).
  
  
  RESULTS
  Twelve patients were identified. Duration of CRVO before surgery ranged from 3 to 19 months (mean, 12.3 months). Preoperative perfusion status was not ischemic in 6 eyes, ischemic in 5 eyes, and indeterminate in 1 eye. Intravitreal triamcinolone had been administered in 66% and was given at least 4 months before surgical intervention. After surgery, foveal thickness and TMV improved, but BCVA demonstrated only a modest improvement that did not reach statistical significance. At the time of surgery, 50% of eyes were pseudophakic. Of the remaining eyes, visually significant cataracts developed in all 6 (100%) within 1 year after surgery, with 67% of those undergoing cataract extraction within 15 months after PPV/MP/EL.
  
  
  CONCLUSIONS
  PPV/MP/EL performed for CME secondary to CRVO reduced foveal thickness and TMV at final follow-up; however, anatomic improvement did not correlate with a statistically significant improvement in BCVA.
authors.affiliation: Duke University Eye Center, Durham, North Carolina 27710, USA.
authors.forename: Francis Char
authors.initials: FC
authors.lastname: DeCroos
authors.forename: R Keith
authors.initials: RK
authors.lastname: Shuler
authors.forename: Sandra
authors.initials: S
authors.lastname: Stinnett
authors.forename: Sharon
authors.initials: S
authors.lastname: Fekrat
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000601:surgery; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D017075:Laser Coagulation / Q000379:methods*; D008269:Macular Edema / Q000209:etiology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012170:Retinal Vein Occlusion / Q000150:complications* / Q000601:surgery; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy / Q000379:methods*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green