title: Metastasis to the nasal cavity from primary rectal adenocarcinoma.
abstract: We describe a rare case of metastasis to the pa ra - na sal sinuses. The lesion had an immunohistochemical (positivity for cytokeratin 20, negativity for cytokeratin 7, overexpression of p53) and in situ hybridisation profile (neither lesions showed deletion for p53) consistent with metastasis from the earlier rectal adenocarcinoma. The correct typification of intestinal-type neoplasms requires a combination of morphological, immunohistochemical and, sometimes, molecular analysis.
authors.affiliation: Institute of Haematology and Oncology, Department of Radiation Oncology, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. cconill@clinic.ub.es
authors.forename: C
authors.initials: C
authors.lastname: Conill
authors.forename: M
authors.initials: M
authors.lastname: Vargas
authors.forename: I
authors.initials: I
authors.lastname: Valduvieco
authors.forename: P L
authors.initials: PL
authors.lastname: Fernández
authors.forename: A
authors.initials: A
authors.lastname: Cardesa
authors.forename: S
authors.initials: S
authors.lastname: Capurro
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009296:Nasal Cavity / Q000473:pathology*; D009361:Neoplasm Invasiveness / Q000473:pathology; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000556:secondary*; D012004:Rectal Neoplasms / Q000473:pathology*