title: In situ fluoride retention and remineralization of incipient carious lesions after the application of different concentrations of fluoride.
abstract: Limited information is available on the time-dependent or dosage-dependent cariostatic efficacy of highly concentrated fluoride compounds. This good clinical practice-conforming, double-blind, placebo-controlled, crossover in situ study tested the hypothesis that a 1.0% amine fluoride fluid is superior to a 0.5% amine fluoride fluid regarding fluoride retention and mineral change in initial caries enamel lesions over a period of 28 d. Fluoride retention was significantly higher after application of the two fluoride fluids compared with placebo but had decreased in both groups to similar levels after only 1 wk. Mineral gain was significantly higher for both verum groups compared with placebo. The use of 1% fluoride fluid resulted in significantly higher remineralization compared with the use of 0.5% fluoride fluid. For both fluoride fluids mineral gain followed a linear relationship with time during the experimental period, indicating a possible further uptake of mineral, even after 4 wk.
authors.affiliation: Department of Operative Dentistry and Periodontology, University Hospital and Dental School, University of Freiburg, Freiburg, Germany. markus.altenburger@uniklinikfreiburg.de
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Altenburger
authors.forename: Jörg F
authors.initials: JF
authors.lastname: Schirrmeister
authors.forename: Adrian
authors.initials: A
authors.lastname: Lussi
authors.forename: Manfred
authors.initials: M
authors.lastname: Klasser
authors.forename: Elmar
authors.initials: E
authors.lastname: Hellwig
mesh_terms: D000328:Adult; D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage*; D002417:Cattle; D018592:Cross-Over Studies; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005460:Fluorides, Topical / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D014089:Tooth Remineralization / Q000379:methods*; D014093:Tooth, Artificial; D055815:Young Adult
chemical_list: D002327:Cariostatic Agents; D005460:Fluorides, Topical; C094808:amine fluoride solution