title: Neural functional organization of hallucinations in schizophrenia: multisensory dissolution of pathological emergence in consciousness.
abstract: Although complex hallucinations are extremely vivid, painful symptoms in schizophrenia, little is known about the underlying mechanisms of multisensory integration in such a phenomenon. We investigated the neural basis of these altered states of consciousness in a patient with schizophrenia, by combining state of the art neuroscientific exploratory methods like functional MRI, diffusion tensor imaging, cortical thickness analysis, electrical source reconstruction and trans-cranial magnetic stimulation. The results shed light on the functional architecture of the hallucinatory processes, in which unimodal information from different modalities is strongly functionally connected to higher-order integrative areas.
authors.affiliation: Laboratoire de Neurosciences Fonctionnelles et Pathologies, CNRS UMR-8160, Hôpital Roger Salengro, Université Lille Nord de France, Centre Hospitalier Universitaire de Lille, 59037 Lille cedex, France. r-jardri@chru-lille.fr
authors.forename: Renaud
authors.initials: R
authors.lastname: Jardri
authors.forename: Delphine
authors.initials: D
authors.lastname: Pins
authors.forename: Maxime
authors.initials: M
authors.lastname: Bubrovszky
authors.forename: Bernard
authors.initials: B
authors.lastname: Lucas
authors.forename: Vianney
authors.initials: V
authors.lastname: Lethuc
authors.forename: Christine
authors.initials: C
authors.lastname: Delmaire
authors.forename: Vincent
authors.initials: V
authors.lastname: Vantyghem
authors.forename: Pascal
authors.initials: P
authors.lastname: Despretz
authors.forename: Pierre
authors.initials: P
authors.lastname: Thomas
mesh_terms: D000328:Adult; D000465:Algorithms; D001284:Atrophy; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D003243:Consciousness / Q000502:physiology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004292:Dominance, Cerebral / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D005625:Frontal Lobe / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000503:physiopathology; D006212:Hallucinations / Q000503:physiopathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009415:Nerve Net / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D009778:Occipital Lobe / Q000503:physiopathology; D009929:Organ Size / Q000502:physiology; D010465:Perception / Q000502:physiology*; D011569:Psychiatric Status Rating Scales; D012563:Schizophrenia, Paranoid / Q000503:physiopathology* / Q000523:psychology; D012815:Signal Processing, Computer-Assisted; D012984:Software; D013702:Temporal Lobe / Q000503:physiopathology; D050781:Transcranial Magnetic Stimulation / Q000379:methods