title: Tissue Doppler echocardiography for predicting arterial stiffness assessed by cardio-ankle vascular index.
abstract: It has been reported that left ventricular (LV) diastolic functional parameters assessed by conventional Doppler echocardiography, which measures blood flow velocities in cardiac cavity, correlate with arterial stiffness assessed by the cardio-ankle vascular index (CAVI) and are markers for increased risk of cardiovascular events. Recently, tissue Doppler echocardiography, which measures velocities of regional cardiac wall, has been widely used for assessment of LV diastolic function because of more accuracy than conventional Doppler echocardiography. However, there are no data regarding the ability of tissue Doppler echocardiography for predicting increased arterial stiffness. We investigated the correlation of LV diastolic functional parameters from tissue Doppler echocardiography to CAVI in order to clarify the ability of tissue Doppler echocardiography for predicting increased arterial stiffness in patients with cardiovascular risk factors. Enrolled in the study were 70 patients (69 +/- 8 years) who had no overt heart disease, but had at least one of hypertension, diabetes, and dyslipidemia. The peak early diastolic mitral annular velocity (E') was measured as an index of LV diastolic function using tissue Doppler echocardiography. The E' was correlated with CAVI (r = -0.518, p < 0.001). The optimal cut-off point for the detection of abnormal CAVI (> or = 8.81) was 5.6 cm/s for E' (sensitivity 71%, specificity 71%). The decrease in E' correlated with both LV diastolic dysfunction and increased arterial stiffness. Therefore, the LV diastolic dysfunction assessed by tissue Doppler echocardiography may be useful for predicting increased arterial stiffness and cardiovascular events in the patients with risk factors.
authors.affiliation: Department of Integrated Medicine, Kagawa University, 1750-1 Miki-cho, Kagawa, Japan. masugata@med.kagawa-u.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Masugata
authors.forename: Shoichi
authors.initials: S
authors.lastname: Senda
authors.forename: Fuminori
authors.initials: F
authors.lastname: Goda
authors.forename: Ayumu
authors.initials: A
authors.lastname: Yamagami
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okuyama
authors.forename: Takeaki
authors.initials: T
authors.lastname: Kohno
authors.forename: Naohisa
authors.initials: N
authors.lastname: Hosomi
authors.forename: Kazushi
authors.initials: K
authors.lastname: Yukiiri
authors.forename: Takahisa
authors.initials: T
authors.lastname: Noma
authors.forename: Hideyasu
authors.initials: H
authors.lastname: Kiyomoto
authors.forename: Koji
authors.initials: K
authors.lastname: Murao
authors.forename: Akira
authors.initials: A
authors.lastname: Nishiyama
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kohno
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000843:Ankle Joint / Q000098:blood supply*; D001158:Arteries / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology*; D001783:Blood Flow Velocity; D015150:Echocardiography, Doppler; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis