title: Catalytic intermolecular aldehyde-ketone coupling via acyl phosphonates.
abstract: The first catalytic intermolecular aldehyde-ketone coupling via acyl phosphonate is reported. Acyl phosphonates are potent acyl anion precursors, which generate acyl anion equivalents under the influence of cyanide anion via phosphonate-phosphate rearrangement. These anions readily react with activated ketones to form acyloin type coupling in 41-95% yields.
authors.affiliation: Department of Chemistry, Middle East Technical University, 06531 Ankara, Turkey. asdemir@metu.edu.tr
authors.forename: Ayhan S
authors.initials: AS
authors.lastname: Demir
authors.forename: Lker
authors.initials: L
authors.lastname: Esiringü
authors.forename: Mehmet
authors.initials: M
authors.lastname: Göllü
authors.forename: Omer
authors.initials: O
authors.lastname: Reis
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007659:Ketones; D063065:Organophosphonates