title: Association of single-nucleotide polymorphism 3 and c.553G>T of APOA5 with hypertriglyceridemia after treatment with highly active antiretroviral therapy containing protease inhibitors in hiv-infected individuals in Taiwan.
abstract: We investigated the relationship between hypertriglyceridemia and the single-nucleotide polymorphisms (SNPs) on APOA5 in human immunodeficiency virus (HIV)-infected patients receiving highly active antiretroviral therapy (HAART) in Taiwan. Receipt of protease inhibitor-based HAART, high baseline triglyceride levels, and carriage of APOA5 SNP3 or c.553G>T variants or APOA5 SNP1T/SNP2G/SNP3C/c.553T haplotype were statistically significantly associated with development of extreme hypertriglyceridemia (triglyceride level, >500 mg/dL).
authors.affiliation: Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.
authors.forename: Sui-Yuan
authors.initials: SY
authors.lastname: Chang
authors.forename: Wei-Shin
authors.initials: WS
authors.lastname: Ko
authors.forename: Jau-Tsuen
authors.initials: JT
authors.lastname: Kao
authors.forename: Lan-Yang
authors.initials: LY
authors.lastname: Chang
authors.forename: Hsin-Yun
authors.initials: HY
authors.lastname: Sun
authors.forename: Mao-Yuan
authors.initials: MY
authors.lastname: Chen
authors.forename: Szu-Min
authors.initials: SM
authors.lastname: Hsieh
authors.forename: Wang-Huei
authors.initials: WH
authors.lastname: Sheng
authors.forename: Shu-Fang
authors.initials: SF
authors.lastname: Chang
authors.forename: Wen-Chun
authors.initials: WC
authors.lastname: Liu
authors.forename: Cheng-Hsin
authors.initials: CH
authors.lastname: Wu
authors.forename: Hui-Jen
authors.initials: HJ
authors.lastname: Hsu
authors.forename: Chuan-Liang
authors.initials: CL
authors.lastname: Kao
authors.forename: Chun-Nan
authors.initials: CN
authors.lastname: Lee
authors.forename: Chien-Ching
authors.initials: CC
authors.lastname: Hung
authors.forename: Shan-Chwen
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D017320:HIV Protease Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D006239:Haplotypes; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan; D055815:Young Adult
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D017320:HIV Protease Inhibitors