title: Correlation between pulse wave velocity and fluid distribution in hemodialysis patients.
abstract: BACKGROUND
  In this study, we focused on whether volume overload plays a role in the development of arterial stiffness.
  
  
  METHODS
  Seventy-three prevalent hemodialysis patients were enrolled in a cross-sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV), and volume overload was assessed by bioimpedance analysis.
  
  
  RESULTS
  Patients were divided into a high PWV group and a low PWV group based on the median of PWV. Age, systolic blood pressure, pulse pressure (PP), extracellular water/total body water ratio (ECW/TBW), diabetic status (all p < 0.01), and history of cardiac events (p < 0.05) were significantly higher in the high PWV group (n = 37) than in the low PWV group. In the correlation analysis, PWV was positively associated with PP, systolic blood pressure, ECW/TBW, age, history of cardiac events, and diabetes (all p < 0.01). Multiple regression analysis showed that PWV was independently related to PP and ECW/TBW (p < 0.01).
  
  
  CONCLUSIONS
  Volume overload plays an important role in the development of arterial stiffness in hemodialysis patients.
authors.affiliation: Division of Nephrology, Peking University Third Hospital, Beijing, PR China. dxzheng@sina.com
authors.forename: Danxia
authors.initials: D
authors.lastname: Zheng
authors.forename: Li-Tao
authors.initials: LT
authors.lastname: Cheng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhuang
authors.forename: Yue
authors.initials: Y
authors.lastname: Gu
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Tang
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014655:Vascular Resistance