title: Monitoring of cell cultures with LTCC microelectrode array.
abstract: Monitoring of cell cultures in microbioreactors is a crucial task in cell bioassays and toxicological tests. In this work a novel tool based on a miniaturized sensor array fabricated using low-temperature cofired ceramics (LTCC) technology is presented. The developed device is applied to the monitoring of cell-culture media change, detection of the growth of various species, and in toxicological studies performed with the use of cells. Noninvasive monitoring performed with the LTCC microelectrode array can be applied for future cell-engineering purposes.
authors.affiliation: Warsaw University of Technology, Faculty of Chemistry, Noakowskiego 3, 00-664, Warsaw, Poland. pciosek@ch.pw.edu.pl
authors.forename: P
authors.initials: P
authors.lastname: Ciosek
authors.forename: K
authors.initials: K
authors.lastname: Zawadzki
authors.forename: J
authors.initials: J
authors.lastname: Łopacińska
authors.forename: M
authors.initials: M
authors.lastname: Skolimowski
authors.forename: P
authors.initials: P
authors.lastname: Bembnowicz
authors.forename: L J
authors.initials: LJ
authors.lastname: Golonka
authors.forename: Z
authors.initials: Z
authors.lastname: Brzózka
authors.forename: W
authors.initials: W
authors.lastname: Wróblewski
mesh_terms: D000818:Animals; D019149:Bioreactors; D018929:Cell Culture Techniques / Q000379:methods*; D002522:Chlorocebus aethiops; D003080:Cold Temperature; D003470:Culture Media / Q000032:analysis* / Q000737:chemistry; D006801:Humans; D008839:Microelectrodes; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D055616:Microtechnology / Q000379:methods*; D008904:Miniaturization; D014116:Toxicology; D014407:Tumor Cells, Cultured; D014709:Vero Cells
chemical_list: D003470:Culture Media