Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system.
Most visual screens based on fluorescent markers are currently limited in throughput and accuracy. Here we present the first genetic screen of a mutagenized population of C. elegans in a microfluidic device. Animal handling streamlined by a microfluidic device and intuitive control software enabled the identification of novel mutants and a large screening speed.
Crane
Matthew M
MM
Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, GA, USA.
Chung
Kwanghun
K
Lu
Hang
H
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D003201:Computers; D044085:Microfluidics; D012984:Software