title: Ontology driven integration platform for clinical and translational research.
abstract: Semantic Web technologies offer a promising framework for integration of disparate biomedical data. In this paper we present the semantic information integration platform under development at the Center for Clinical and Translational Sciences (CCTS) at the University of Texas Health Science Center at Houston (UTHSC-H) as part of our Clinical and Translational Science Award (CTSA) program. We utilize the Semantic Web technologies not only for integrating, repurposing and classification of multi-source clinical data, but also to construct a distributed environment for information sharing, and collaboration online. Service Oriented Architecture (SOA) is used to modularize and distribute reusable services in a dynamic and distributed environment. Components of the semantic solution and its overall architecture are described.
authors.affiliation: The University of Texas Health Science Center at Houston, Houston, Texas, USA. Parsa.Mirhaji@uth.tmc.edu
authors.forename: Parsa
authors.initials: P
authors.lastname: Mirhaji
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Mattew
authors.initials: M
authors.lastname: Vagnoni
authors.forename: Elmer V
authors.initials: EV
authors.lastname: Bernstam
authors.forename: Jiajie
authors.initials: J
authors.lastname: Zhang
authors.forename: Jack W
authors.initials: JW
authors.lastname: Smith
mesh_terms: D035843:Biomedical Research; D019295:Computational Biology / Q000379:methods*; D003628:Database Management Systems; D016247:Information Storage and Retrieval / Q000379:methods*; D020407:Internet; D008490:Medical Informatics; D012984:Software; D018511:Systems Integration; D014584:User-Computer Interface; D018875:Vocabulary, Controlled