title: [Remifentanil and fentanyl combined with propofol administered by target controlled infusion in neurosurgery].
abstract: OBJECTIVE
  To compare the hemodynamics and post-anesthetic recovery of total intravenous anesthesia (TIVA) with remifentanil or fentanyl combined with propofol administered by target controlled infusion (TCI) in neurosurgery.
  
  
  METHODS
  A total of 80 patients undergoing selective neurosurgery were randomly divided into a remifentanil group (Group R, n=40) and a fentanyl group (Group F, n=40). In Group R,remifentanil and propofol was administered by TCI and the blood concentration were 3 approximately 5 microg/L and 3 approximately 5 mg/L each. In Group F, fentanyl was continuously infused at 2 approximately 3 microg/(kg.h) and propofol was administered by TCI with the same blood concentration as that in Group R.Vecuronium was injected at intervals to maintain muscle relaxant.Mean arterial pressure and heart rate during the anesthesia and post-anesthetic recovery were recorded.
  
  
  RESULTS
  Mean arterial pressure of all the patients was decreased significantly from induction of anesthesia to termination of operation compared with that before the induction( P<0.01). The heart rate of Group R was increased obviously from recovery of respiration to extubation and heart rate of Group F was decreased obviously from fixed headframe to termination of operation compared with that before the induction (P<0.01). But there was no significant difference between the 2 groups (P>0.05). The eyes opened and extubed time of Group R were decurtated obviously and the scores of pain were increased significantly (P<0.01).
  
  
  CONCLUSIONS
  TIVA with remifentanil or fentanyl combined with propofol administered by TCI in neurosurgical operation can provided steadible hemodynamics. Resuscitation of remifentanil with propofol administered by target controlled infusion were more quickly but the scores of pain were more higher than that of fentanyl.
authors.affiliation: Department of Anesthesiology, Xiangya Hospital, Central South University,Changsha 410008, China.
authors.forename: Nianyue
authors.initials: N
authors.lastname: Bai
authors.forename: Qulian
authors.initials: Q
authors.lastname: Guo
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Cheng
authors.forename: Yueling
authors.initials: Y
authors.lastname: Wang
authors.forename: Shenghui
authors.initials: S
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous / Q000379:methods; D018686:Anesthetics, Intravenous / Q000008:administration & dosage; D003399:Craniotomy; D005260:Female; D005283:Fentanyl; D006801:Humans; D007260:Infusion Pumps; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010880:Piperidines; D015742:Propofol; D000077208:Remifentanil; D014673:Vecuronium Bromide / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D018686:Anesthetics, Intravenous; D010880:Piperidines; D014673:Vecuronium Bromide; D000077208:Remifentanil; D005283:Fentanyl; D015742:Propofol