D-amino acid oxidase: physiological role and applications.
D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.
Khoronenkova
S V
SV
Chemistry Faculty, Lomonosov Moscow State University, Moscow, 119992, Russia.
Tishkov
V I
VI
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D003605:D-Amino-Acid Oxidase / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D004718:Saccharomycetales / Q000201:enzymology
D000596:Amino Acids; D003605:D-Amino-Acid Oxidase