Elongator bridges tubulin acetylation and neuronal migration.
Neuronal cell migration and maturation are crucial for the development of the mammalian cerebral cortex. In this issue, Creppe et al. (2009) now show that the multisubunit histone acetyltransferase Elongator may regulate migration and branch formation of cortical neurons in the developing mouse brain by acetylating alpha-tubulin.
Wynshaw-Boris
Anthony
A
Department of Pediatrics and Institute for Human Genetics, University of California, San Francisco, School of Medicine, San Francisco, CA 94143-0794, USA. wynshawborist@peds.ucsf.edu
D000107:Acetylation; D000818:Animals; D002465:Cell Movement; D051548:Histone Acetyltransferases / Q000378:metabolism*; D051379:Mice; D055495:Neurogenesis; D009474:Neurons / Q000378:metabolism*; D014404:Tubulin / Q000378:metabolism*
D014404:Tubulin; D051548:Histone Acetyltransferases