title: [Pulmonary hypertension in a patient on chronic hemodialysis].
abstract: A 52-year-old woman with end-stage renal disease and long-term hemodialysis complained of worsening exertional dyspnea. A chest X-ray showed cardiomegaly. She was admitted to our hospital because an echocardiogram suggested pulmonary hypertension. Right heart catheterization revealed pulmonary hypertension, but pulmonary perfusion scintigraphy with Tc-99m-MAA showed no evidence of pulmonary thromboembolism. We gave her a diagnosis of pulmonary arterial hypertension associated with Sjögren syndrome on the basis of a positive serological test (SS-A. SS-B) and the findings of lip biopsy. After four months of therapy with bosentan, her 6-minute walk distance, estimated pulmonary arterial pressure and brain natriuretic peptide (BNP) improved. Bosentan is mainly cleared by hepatic elimination and its dialysis clearance is low. Bosentan for the treatment of pulmonary hypertension was safe as well as effective in this patient with end-stage renal disease and hemodialysis. In consideration of the relationship between pulmonary hypertension and end-stage renal disease, and hemodialysis, bosentan was considered to be a reasonable and effective treatment.
authors.affiliation: Department of Respirology, Graduate School of Medicine, Chiba University.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yasuda
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Tanabe
authors.forename: Kenji
authors.initials: K
authors.lastname: Konishi
authors.forename: Ayako
authors.initials: A
authors.lastname: Shigeta
authors.forename: Masao
authors.initials: M
authors.lastname: Shinohara
authors.forename: Shinichi
authors.initials: S
authors.lastname: Toyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Miki
authors.initials: M
authors.lastname: Maruoka
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kuriyama
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000077300:Bosentan; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000628:therapy; D008875:Middle Aged; D006435:Renal Dialysis; D012859:Sjogren's Syndrome / Q000150:complications; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D013449:Sulfonamides; D000077300:Bosentan