Importance of the backbone conformation of (-)-ternatin in its fat-accumulation inhibitory activity against 3T3-L1 adipocytes.
Key relationships between the intramolecular H-bond-derived backbone conformation and the bioactivity of the novel fat-accumulation inhibitor (-)-ternatin are examined by analyses of the NMR spectroscopic data and CD spectra of designed analogues. The results reveal that the beta-turn structure of (-)-ternatin is responsible for its potent fat-accumulation inhibitory effect against 3T3-L1 murine adipocytes.
Shimokawa
Kenichiro
K
Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa, Nagoya 464-8602, Japan.
Miwa
Ryoka
R
Yamada
Kaoru
K
Uemura
Daisuke
D
D041721:3T3-L1 Cells; D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D004041:Dietary Fats / Q000037:antagonists & inhibitors*; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009765:Obesity / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D004041:Dietary Fats; D005419:Flavonoids; C051080:ternatin (flavonoid)