Natural product inhibitors of Hsp90: potential leads for drug discovery.
Heat shock protein 90 has emerged as a promising target for the treatment of cancer and neurodegenerative diseases. This review summarizes recent advancements towards the development of natural products as they pertain to the biological and chemical understanding of this molecular chaperone.
Amolins
M W
MW
Department of Medicinal Chemistry, The University of Kansas, 1251 Wescoe Hall Drive, Malott 4070, Lawrence, Kansas 66045-7563, USA.
Blagg
B S J
BS
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001688:Biological Products / Q000494:pharmacology*; D015195:Drug Design; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors*; D006801:Humans; D017510:Protein Folding; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D001688:Biological Products; D018841:HSP90 Heat-Shock Proteins