Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.
Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.
Hütter
Gero
G
Department of Hematology, Oncology, and Transfusion Medicine, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Germany. gero.huetter@charite.de
Nowak
Daniel
D
Mossner
Maximilian
M
Ganepola
Susanne
S
Müssig
Arne
A
Allers
Kristina
K
Schneider
Thomas
T
Hofmann
Jörg
J
Kücherer
Claudia
C
Blau
Olga
O
Blau
Igor W
IW
Hofmann
Wolf K
WK
Thiel
Eckhard
E
D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D015704:CD4 Antigens; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004279:DNA, Viral / Q000097:blood; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D019713:Receptors, CCR5 / Q000235:genetics*; D033581:Stem Cell Transplantation; D018183:Transplantation Chimera; D014184:Transplantation, Homologous; D019562:Viral Load
D044966:Anti-Retroviral Agents; D015704:CD4 Antigens; D004279:DNA, Viral; D012367:RNA, Viral; D019713:Receptors, CCR5