title: Transient reduction of spontaneous neuronal network activity by sublethal amyloid beta (1-42) peptide concentrations.
abstract: Soluble amyloid beta(1-42) (A beta(1-42)) peptide has recently been assigned a key role in early Alzheimer's disease (AD) pathophysiology accounting for synaptic dysfunction before amyloid plaque formation and neurodegeneration can occur. Following sublethal A beta(1-42) administration, we observed an acute but transient reduction of the spike and burst rate of spontaneously active cortical networks cultured on microelectrode arrays. This simple experimental system appears suitable for future long-term pharmacological and genetic studies of A beta(1-42) signaling, thus providing a valuable new tool in AD research.
authors.affiliation: Klinik für Psychiatrie und Psychotherapie, Abteilung Experimentelle Gerontopsychiatrie, Heinrich-Heine-Universität, Bergische Landstr. 2, 40629, Düsseldorf, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Görtz
authors.forename: Jessica
authors.initials: J
authors.lastname: Opatz
authors.forename: Mario
authors.initials: M
authors.lastname: Siebler
authors.forename: Susanne Aileen
authors.initials: SA
authors.lastname: Funke
authors.forename: Dieter
authors.initials: D
authors.lastname: Willbold
authors.forename: Christian
authors.initials: C
authors.lastname: Lange-Asschenfeldt
mesh_terms: D000200:Action Potentials / Q000187:drug effects* / Q000502:physiology; D016229:Amyloid beta-Peptides / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D000818:Animals; D018929:Cell Culture Techniques; D002540:Cerebral Cortex / Q000166:cytology*; D004594:Electrophysiology; D008839:Microelectrodes; D009415:Nerve Net / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010446:Peptide Fragments / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42)