Less is more for leaderless mRNA translation.
In this issue of Molecular Cell, Kaberdina et al. (2009) show that prolonged exposure of ribosomes to the antibiotic kasugamycin triggers the spontaneous loss of small subunit proteins and produces a reduced ribosomal particle that exclusively translates leaderless mRNAs.
Wilson
Daniel N
DN
Gene Center, Department for Chemistry and Biochemistry, University of Munich, Munich, Germany. wilson@lmb.uni-muenchen.de
D000617:Aminoglycosides / Q000494:pharmacology; D008954:Models, Biological; D008958:Models, Molecular; D014176:Protein Biosynthesis / Q000502:physiology*; D011487:Protein Conformation; D012333:RNA, Messenger / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism
D000617:Aminoglycosides; D012333:RNA, Messenger; C100305:kasugamycin