Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome.
OBJECTIVE
To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS).


METHODS
Case-control study.


METHODS
University Department of Obstetrics and Gynecology.


METHODS
Women with (n = 138) or without (n = 290) PCOS.


METHODS
Genotyping was performed by polymerase chain reaction-restriction fragment-length polymorphism analysis.


METHODS
Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene.


RESULTS
There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GG rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes.


CONCLUSIONS
The ER-beta gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS.
Kim
Jin Ju
JJ
Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
Choi
Young Min
YM
Choung
Seon Ha
SH
Yoon
Sang Ho
SH
Lee
Gyoung Hoon
GH
Moon
Shin Yong
SY
D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
D047629:Estrogen Receptor beta