Highly functional group tolerance in copper-catalyzed N-arylation of nitrogen-containing heterocycles under mild conditions.
A copper-catalyzed process has been developed for the N-arylation reaction under very mild conditions in the absence of additional ligand. This protocol could not only tolerate an array of thermally sensitive functional groups, but also achieve high chemoselectivity.
Zhu
Liangbo
L
Key Laboratory of Green Chemistry and Technology of Ministry of Education, College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, People's Republic of China.
Li
Gaocan
G
Luo
Liang
L
Guo
Peng
P
Lan
Jingbo
J
You
Jingsong
J
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006846:Hydrocarbons, Halogenated / Q000737:chemistry; D015394:Molecular Structure; D009584:Nitrogen / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature
D006571:Heterocyclic Compounds; D006846:Hydrocarbons, Halogenated; D003300:Copper; D009584:Nitrogen