[Protein level of transcription factors AP-1 and NF-kappaB in selected human gastrointestinal tract tumors].
Transcription factors AP-1 and NF-kappaB control important cell processes like proliferation, apoptosis and differentiation. Disturbance of this processes is often a reason of carcinogenesis. Therefore AP-1 and NF-kappaB might have an important role in arising and development of tumors.


OBJECTIVE
An evaluation of changes of AP-1 and NF-kappaB protein level in selected human alimentary tract tumors. Material and methods. Materials were obtained from patients with alimentary tract tumors (stomach, liver; colon), diagnosed by routine histopathological examination. Normal tissues were taken more than 6-7 cm away from tumor border (histologically examined). Protein level of AP-1 and NF-kappaB was detected by standard Western blotting technique.


RESULTS
In all examined alimentary tract tumors (gastric adenocarcinoma, hepatocellular carcinoma, colorectal adenocarcinoma and liver metastases) we observed changes in AP-1 and NF-kappaB protein level comparing with normal tissues.


CONCLUSIONS
Changes in AP-1 and NF-kappaB expression indicate, that they are important factors not only in initiation, but also in further development of digestive tract tumors.
Skrzycki
Michał
M
Warszawski Uniwersytet Medyczny, Katedra i Zakład Biochemii.
Scibior-Bentkowska
Dorota
D
Podsiad
Małgorzata
M
Czeczot
Hanna
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000556:secondary; D008297:Male; D008875:Middle Aged; D016328:NF-kappa B / Q000378:metabolism*; D018808:Transcription Factor AP-1 / Q000378:metabolism*
D014408:Biomarkers, Tumor; D016328:NF-kappa B; D018808:Transcription Factor AP-1