title: Alkylating ability of artemisinin after Cu(I)-induced activation.
abstract: The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin-copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is similar to that of Fe(II) analogues, even though the reaction is more sluggish and product distribution slightly different.
authors.affiliation: Laboratoire de Chimie de Coordination du CNRS, Toulouse cedex 4, France.
authors.forename: Fatima
authors.initials: F
authors.lastname: Bousejra-El Garah
authors.forename: Marguerite
authors.initials: M
authors.lastname: Pitié
authors.forename: Laure
authors.initials: L
authors.lastname: Vendier
authors.forename: Bernard
authors.initials: B
authors.lastname: Meunier
authors.forename: Anne
authors.initials: A
authors.lastname: Robert
mesh_terms: D000477:Alkylating Agents / Q000737:chemistry*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry*; D037621:Artemisinins / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005978:Glutathione / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012492:Salts / Q000737:chemistry
chemical_list: D000477:Alkylating Agents; D000890:Anti-Infective Agents; D037621:Artemisinins; D012492:Salts; D003300:Copper; C031327:artemisinin; D005978:Glutathione