Glioblastoma in multiple sclerosis: a case report.
Cerebral tumor and multiple sclerosis (MS) relapses can show overlapping clinical and magnetic resonance imaging features. In a previous study we observed in relapsing MS patients increased T-bet, pSTAT1, and pSTAT3 expressions in circulating mononuclear cells. During the data analysis we observed that T-bet, pSTAT1, and pSTAT3 expression was not increased in circulating mononuclear cells from a relapsing-remitting (RR)MS patient with recent onset of new neurological signs due to glioblastoma multiforme. In conclusion, our patient represents an exemplary case which suggests that T-bet, pSTAT1, and pSTAT3 expression in peripheral blood mononuclear cells (PBMCs) might be useful to differentiate MS relapses from other noninflammatory diseases.
Frisullo
Giovanni
G
Department of Neuroscience, Institute of Neurology, Catholic University, Largo Agostino Gemelli, 8, Rome 00168, Italy.
Patanella
Agata Katia
AK
Nociti
Viviana
V
Cianfoni
Alessandro
A
Iorio
Raffaele
R
Bianco
Assunta
A
Marti
Alessandro
A
Tonali
Pietro Attilio
PA
Batocchi
Anna Paola
AP
D001932:Brain Neoplasms / Q000150:complications* / Q000276:immunology / Q000473:pathology; D005909:Glioblastoma / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D050794:STAT1 Transcription Factor; D050796:STAT3 Transcription Factor / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory
D050794:STAT1 Transcription Factor; D050796:STAT3 Transcription Factor