title: Botulinum toxin prevents radiotherapy-induced salivary gland damage.
abstract: Radiotherapy of head and neck malignancies results in severe damage to salivary glands. Irradiation-induced sialadenitis with xerostomia leads to a significant deterioration of the quality of life which lasts life-long. Here we show in a preliminary study that intraglandular application of botulinum toxin performed prior to radiation reduces significantly the radiation induced toxicity of the glandular tissue in rats.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Philipp University, Marburg, Germany. teymoort@med.uni-marburg.de
authors.forename: Afshin
authors.initials: A
authors.lastname: Teymoortash
authors.forename: Felix
authors.initials: F
authors.lastname: Müller
authors.forename: Janko
authors.initials: J
authors.lastname: Juricko
authors.forename: Michael
authors.initials: M
authors.lastname: Bieker
authors.forename: Robert
authors.initials: R
authors.lastname: Mandic
authors.forename: Damiano
authors.initials: D
authors.lastname: Librizzi
authors.forename: Helmut
authors.initials: H
authors.lastname: Höffken
authors.forename: Andeas
authors.initials: A
authors.lastname: Pfestroff
authors.forename: Jochen Alfred
authors.initials: JA
authors.lastname: Werner
mesh_terms: D000818:Animals; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D001905:Botulinum Toxins / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D012793:Sialadenitis / Q000517:prevention & control*; D013363:Submandibular Gland / Q000000981:diagnostic imaging / Q000528:radiation effects*
chemical_list: D018726:Anti-Dyskinesia Agents; D011837:Radiation-Protective Agents; D001905:Botulinum Toxins