Epithelioid osteosarcoma of the jaw.
Epithelioid osteosarcoma (OS) is a rare sub-type of OS with an aggressive behavior. An epithelioid OS was diagnosed in an 8-year-old female with painful swelling of the left jaw. After two courses of chemotherapy (cisplatin/methotrexate/doxorubicin), the patient presented a progressive disease. After hemimandibulectomy, 13 courses of post-operative chemotherapy (cisplatin/methotrexate/doxorubicin/ifosfamide) were performed. Histological and ultra-structural examination showed a high grade neoplasm consisting of sheets of epithelioid cells with focal osteoid formation. The patient is alive and in complete remission 42 months from diagnosis.
Cozza
Raffaele
R
Division of Oncology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
Devito
Rita
R
De Ioris
Maria Antonietta
MA
Zama
Mario
M
Boldrini
Renata
R
Fidani
Paola
P
Donfrancesco
Alberto
A
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007573:Jaw Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage; D012516:Osteosarcoma / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome
D004317:Doxorubicin; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate