Essential role of SBP-1 activation in oxygen deprivation induced lipid accumulation and increase in body width/length ratio in Caenorhabditis elegans.
Epidemiological evidence suggests a link between chronic oxygen starvation and fat accumulation/obesity, however the underlying mechanism remains unclear. Using Caenorhabditis elegans we found extended oxygen deprivation resulted in activation of SBP-1, the worm homologue of SREBP1, a transcription factor important in maintaining lipid homeostasis. SBP-1 knockdown prevented hypoxia-induced fat accumulation and the associated increase in worm width/length ratio, demonstrating that SBP-1/SREBP1 plays an essential role in hypoxia-induced lipid accumulation and body shape alteration. This study provides the first evidence suggesting that activation of SREBP1 may be a critical pathogenic factor contributing to chronic hypoxia associated excessive fat accumulation/obesity in humans.
Taghibiglou
Changiz
C
Department of Medicine, UBC, Canada; Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 2B5.
Martin
Henry G S
HG
Rose
Jacqueline K
JK
Ivanova
Nadia
N
Lin
Conny H C
CH
Lau
H Lee
HL
Rai
Susan
S
Wang
Yu Tian
YT
Rankin
Catharine H
CH
D000818:Animals; D049628:Body Size; D017173:Caenorhabditis elegans / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008055:Lipids / Q000032:analysis / Q000096:biosynthesis*; D010100:Oxygen / Q000378:metabolism*; D034622:RNA Interference; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D029742:Caenorhabditis elegans Proteins; D008055:Lipids; C513283:SBP-1 protein, C elegans; D014157:Transcription Factors; D010100:Oxygen