BRCTing up is hard to do.
In this issue of Molecular Cell, Usui et al. (2009) show that Mec1-phosphorylated Rad9 SCD interacts with the BRCT domain, promoting oligomerization. This sustains the DNA damage checkpoint and is suppressed by Rad53 phosphorylation in a negative feedback circuit.
Stern
David F
DF
Department of Pathology, Yale University School of Medicine, New Haven, CT 06520-8023, USA. df.stern@yale.edu
D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D008954:Models, Biological; D010766:Phosphorylation; D017434:Protein Structure, Tertiary