title: Factors related to the presentation of thin and thick nodular melanoma from a population-based cancer registry in Queensland Australia.
abstract: BACKGROUND
  Worldwide, the incidence of thick melanoma has not declined, and the nodular melanoma (NM) subtype accounts for nearly 40% of newly diagnosed thick melanoma. To assess differences between patients with thin (<or=2.00 mm) and thick (>or=2.01 mm) nodular melanoma, the authors evaluated factors such as demographics, melanoma detection patterns, tumor visibility, and physician screening for NM alone and compared clinical presentation and anatomic location of NM with superficial spreading melanoma (SSM).
  
  
  METHODS
  The authors used data from a large population-based study of Queensland (Australia) residents diagnosed with melanoma. Queensland residents aged 20 to 75 years with histologically confirmed first primary invasive cutaneous melanoma were eligible for the study, and all questionnaires were conducted by telephone (response rate, 77.9%).
  
  
  RESULTS
  During this 4-year period, 369 patients with nodular melanoma were interviewed, of whom 56.7% were diagnosed with tumors <or=2.00 mm. Men, older individuals, and those who had not been screened by a physician in the past 3 years were more likely to have nodular tumors of greater thickness. Thickest nodular melanoma (4 mm+) was also most common in persons who had not been screened by a physician within the past 3 years (odds ratio, 3.75; 95% confidence interval, 1.47-9.59). Forty-six percent of patients with thin nodular melanoma (<or=2.00 mm) reported a change in color, compared with 64% of patients with thin SSM and 26% of patients with thick nodular melanoma (>2.00 mm).
  
  
  CONCLUSIONS
  Awareness of factors related to earlier detection of potentially fatal nodular melanomas, including the benefits of a physician examination, should be useful in enhancing public and professional education strategies. Particular awareness of clinical warning signs associated with thin nodular melanoma should allow for more prompt diagnosis and treatment of this subtype.
authors.affiliation: Division of Public Health Practice, Harvard School of Public Health, Boston, Massachusetts 02215, USA. ageller@hsph.harvard.edu
authors.forename: Alan C
authors.initials: AC
authors.lastname: Geller
authors.forename: Mark
authors.initials: M
authors.lastname: Elwood
authors.forename: Susan M
authors.initials: SM
authors.lastname: Swetter
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Brooks
authors.forename: Joanne
authors.initials: J
authors.lastname: Aitken
authors.forename: Philippa H
authors.initials: PH
authors.lastname: Youl
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Demierre
authors.forename: Peter D
authors.initials: PD
authors.lastname: Baade
mesh_terms: D000328:Adult; D000368:Aged; D055088:Early Detection of Cancer; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000473:pathology*; D008875:Middle Aged; D010808:Physical Examination; D011793:Queensland / Q000453:epidemiology; D012042:Registries; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology*; D011795:Surveys and Questionnaires