title: Fever of unknown origin in renal transplant patients with tacrolimus.
abstract: The immunosuppressive agent tacrolimus is now widely used for the prevention of acute and chronic rejection in renal allograft recipients. We here report on three patients, who developed drug-induced fever due to tacrolimus one to five months after renal transplantation. Extensive search for a focus, autoantibodies and virus infection remained inconclusive. Therefore, drug-induced fever was suggested. After discontinuing tacrolimus and switching to cyclosporine A fever completely resolved within 24 h. This report demonstrates that tacrolimus-induced drug fever should be included in the differential diagnosis of fever of unknown origin in renal transplant recipients.
authors.affiliation: Clinical Division of Nephrology, Innsbruck Medical University, Innsbruck, Austria.
authors.forename: Kathrin
authors.initials: K
authors.lastname: Hochegger
authors.forename: Michael
authors.initials: M
authors.lastname: Rudnicki
authors.forename: Martin
authors.initials: M
authors.lastname: Auinger
authors.forename: Walter
authors.initials: W
authors.lastname: Mark
authors.forename: Raimund
authors.initials: R
authors.lastname: Margreiter
authors.forename: Gert
authors.initials: G
authors.lastname: Mayer
authors.forename: Alexander R
authors.initials: AR
authors.lastname: Rosenkranz
mesh_terms: D000293:Adolescent; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D016559:Tacrolimus / Q000009:adverse effects*
chemical_list: D007166:Immunosuppressive Agents; D002097:C-Reactive Protein; D016559:Tacrolimus