title: Significance of screening tests in diagnosis of infectious mononucleosis.
abstract: The investigation included 91 patients in who an acute or previous EBV infection was established by ELISA test. All patients were also subjected to the Paul-Bunnell-Davidsohn test, while 20 patients were tested by the rapid screening test Clearview IM. The diagnosis of acute infective mononucleosis was in 61 patients (67%) confirmed by the Elisa test, and in 12 patients (19.67%) by the Paul-Bunnell-Davidsohn test, while the rapid screening test Clearview IM demonstrated too low a detection of heterophile antibodies. The rapid screening test was not reliable. In 25% cases, the test was invalid, at early infection stages the rapid test failed to diagnose any case of the EBV virus infection. Paul-Bunell-Davidsohn was often negative, especially with young children. Therefore, priority should be given to virology tests based on the detection of specific antibodies to EBV antigen.
authors.affiliation: Medicinski fakultet, Novi Sad, Institut za javno zdravlje Vojvodine, Novi Sad, Sektor za virusologiju.
authors.forename: Gordana
authors.initials: G
authors.lastname: Kovacević
authors.forename: Ivana
authors.initials: I
authors.lastname: Hrnjaković-Cvjetković
authors.forename: Vesna
authors.initials: V
authors.lastname: Milosević
authors.forename: Vera
authors.initials: V
authors.lastname: Jerant-Patić
authors.forename: Jelena
authors.initials: J
authors.lastname: Radovanov-Tadić
authors.forename: Gordana
authors.initials: G
authors.lastname: Kozoderović
mesh_terms: D000293:Adolescent; D000328:Adult; D015478:Antigens, Heterophile / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis*; D008297:Male; D012698:Serologic Tests; D055815:Young Adult
chemical_list: D015478:Antigens, Heterophile; D000956:Antigens, Viral