Shedding light on tumors using nanoparticles.
The scaffold of nanoparticles (broadly defined as having a size range of 1-100 nm) presents a convenient platform to incorporate multiple functionalities into one single particle for cancer imaging and therapeutics. Whether hollow inside or not, a single nanoparticle can encapsulate a large payload of imaging probes, anticancer drug molecules, or both. On the surface, tumor-specific targeting molecules (e.g., receptor-binding ligands or antibodies) may be immobilized to facilitate active tumor targeting and drug delivery. This versatile nanoplatform promises more efficient delivery of payloads to tumors for improving cancer detection and treatment.
Rao
Jianghong
J
Department of Radiology & Bio-X Program, Stanford University School of Medicine, Stanford, California 94305-5484, USA. jrao@stanford.edu
D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D008856:Microscopy, Fluorescence / Q000379:methods*; D053758:Nanoparticles; D009369:Neoplasms / Q000473:pathology*; D020349:Surface Plasmon Resonance / Q000379:methods*
D003287:Contrast Media