Lupus and T cells.
T-cell abnormalities and aberrant T helper cytokine profiles have been implicated in the loss of immune tolerance to nuclear and cytoplasmic antigens and linked to a variety of clinical manifestations in systemic lupus erythematosus (SLE). Here, we review the role of T cells in promoting and maintaining SLE in relation to their cellular and molecular abnormalities and provide an update on recent T cell-targeted therapeutic approaches for the restoration of T cell homeostasis in the disease.
La Cava
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Division of Rheumatology, Department of Medicine, University of California, Los Angeles, California, USA. alacava@mednet.ucla.edu
D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies