A comparative analysis of the products of GROEL-1 gene from Chlamydia trachomatis serovar D and the HSP60 var1 transcript from Homo sapiens suggests a possible autoimmune response.
Chlamydia trachomatis serovar D produces large quantities of HSP60-1 during infections, which accumulate inside the host cell inducing autoimmunity. We compare the aminoacid sequences of the human HSP60 with the bacterial counterpart to better elucidate how CTHSP60 may simulate HSP60 from human origin during infection and may induce an autoimmune response. As a result of the comparison we suggest several possible epitopes of the CTHSP60, which may induce autoimmunity.
Campanella
C
C
Sezione di Anatomia Umana 'E. Luna', Dipartimento di Medicina Sperimentale, Università di Palermo, Palermo, Italy.
Marino Gammazza
A
A
Mularoni
L
L
Cappello
F
F
Zummo
G
G
Di Felice
V
V
D000595:Amino Acid Sequence; D015551:Autoimmunity; D001483:Base Sequence; D018834:Chaperonin 60 / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D002690:Chlamydia Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D014158:Transcription, Genetic
D018834:Chaperonin 60