[Expression of adenylate kinases 2 in the brains of patients with refractory temporal epilepsy].
OBJECTIVE
To study the protein expression of adenylate kinases (AK)-2 in the brain tissues of patients with drug-refractory temporal epilepsy and the clinical value thereof.


METHODS
Specimens of brain from 40 patients with refractory temporal epilepsy, and 20 sex- and age-matched persons with brain trauma. Immunohistochemistry and immunofluorescence examination were used to test the levels of AK2.


RESULTS
AK2 was expressed in the temporal lobes and hippocampuses of all epileptics, mainly in the cell bodies, and not in the brain tissues of the controls.


CONCLUSIONS
The overexpression of AK2 may be involved in the pathogenesis of drug-refractory epilepsy and become an important symbol thereof.
Zeng
Yan
Y
Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Wang
Xue-Feng
XF
Lin
Tao
T
D000263:Adenylate Kinase / Q000378:metabolism*; D000328:Adult; D017209:Apoptosis; D001921:Brain / Q000378:metabolism*; D004351:Drug Resistance; D004827:Epilepsy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
D007527:Isoenzymes; D000263:Adenylate Kinase; C110938:adenylate kinase 2