Mixed germ cell tumor of the pituitary-hypothalamic region presenting as craniopharyngioma: case report and review of the literature.
Craniopharyngiomas and germ cell tumors (GCT) may affect the pituitary-hypothalamic region during childhood. Although different in origin, their clinical and radiological features may be similar. In this article we present a 5-year-old girl with clinical and radiological findings (computer tomography calcification) that were initially considered as craniopharyngioma. However clinical outcome, blood and cerebral spinal fluid tumoral markers, and results from anatomopathology and immunohistochemistry disclosed a mixed GCT. This case report highlights that some clinical features and radiological findings of pituitary-hypothalamic tumors may be misdiagnosed as craniopharyngioma mainly when there is a mature teratoma with cartilaginous tissue differentiation.
Chang
Claudia Veiga
CV
Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil. chang.cv@gmail.com
Nunes
Vânia dos Santos
Vdos S
Felicio
Andre Carvalho
AC
Zanini
Marco Antonio
MA
Cunha-Neto
Malebranche B C
MB
de Castro
Ana Valeria Barros
AV
D002675:Child, Preschool; D003397:Craniopharyngioma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D013724:Teratoma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery