Antigens of Corynebacterium pseudotuberculosis and prospects for vaccine development.
Corynebacterium pseudotuberculosis continues to cause considerable economic losses in ovine and caprine herds worldwide, causing caseous lymphadenitis. Nevertheless, the immunology of this disease is relatively unknown. Novel antigens may provide vaccines that are more effective and improve diagnostic methods for better control of this disease. The available commercial vaccines are not able to fully protect susceptible animals, cannot be used in all host species and are not licensed for use in many countries. Recent studies on the genomics of C. pseudotuberculosis and on its molecular determinants of virulence should bring us new alternatives for more effective vaccine formulations.
Dorella
Fernanda A
FA
Laboratório de Genética Celular e Molecular, Departamento de Biologia Geral, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, CP: 486 CEP: 31 270-901, Belo Horizonte - MG, Brazil. dorella@icb.ufmg.br
Pacheco
Luis Gc
LG
Seyffert
Núbia
N
Portela
Ricardo W
RW
Meyer
Roberto
R
Miyoshi
Anderson
A
Azevedo
Vasco
V
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D003354:Corynebacterium Infections / Q000517:prevention & control / Q000662:veterinary*; D016925:Corynebacterium pseudotuberculosis / Q000235:genetics / Q000276:immunology*; D015511:Goat Diseases / Q000517:prevention & control*; D006041:Goats; D008199:Lymphadenitis / Q000517:prevention & control / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*
D000942:Antigens, Bacterial