mRNA stability and the unfolding of gene expression in the long-period yeast metabolic cycle.
BACKGROUND
In yeast, genome-wide periodic patterns associated with energy-metabolic oscillations have been shown recently for both short (approx. 40 min) and long (approx. 300 min) periods.


RESULTS
The dynamical regulation due to mRNA stability is found to be an important aspect of the genome-wide coordination of the long-period yeast metabolic cycle. It is shown that for periodic genes, arranged in classes according either to expression profile or to function, the pulses of mRNA abundance have phase and width which are directly proportional to the corresponding turnover rates.


CONCLUSIONS
The cascade of events occurring during the yeast metabolic cycle (and their correlation with mRNA turnover) reflects to a large extent the gene expression program observable in other dynamical contexts such as the response to stresses/stimuli.
Soranzo
Nicola
N
SISSA, via Beirut 4, 34014 Trieste, Italy. soranzo@sissa.it
Zampieri
Mattia
M
Farina
Lorenzo
L
Altafini
Claudio
C
D019295:Computational Biology; D004734:Energy Metabolism / Q000235:genetics* / Q000502:physiology; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D008954:Models, Biological; D020871:RNA Stability / Q000502:physiology*; D012044:Regression Analysis; D013997:Time Factors; D015003:Yeasts