Synthesis of some N, n'-diacylhydrazine derivatives with radical-scavenging and antifungal activity.
A series of N,N'-diacylhydrazines were prepared and their structures were confirmed by 1H NMR, MS and FTICR-MS. They were tested radical-scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical-scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structure-activity relationships about the fungicidal activity, a three-dimensional quantitative structure-activity relationship analysis using the method of comparative molecular field analysis was performed.
Liu
Xing-Hai
XH
State-Key Laboratory of Elemento-Organic Chemistry, National Pesticide Engineering Research Center (Tianjin), Nankai University, Tianjin 300071, China.
Shi
Yan-Xia
YX
Ma
Yi
Y
He
Guo-Rong
GR
Dong
Wei-Li
WL
Zhang
Chuan-Yu
CY
Wang
Bao-Lei
BL
Wang
Su-Hua
SH
Li
Bao-Ju
BJ
Li
Zheng-Ming
ZM
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008956:Models, Chemical; D021281:Quantitative Structure-Activity Relationship
D000935:Antifungal Agents; D016166:Free Radical Scavengers; D006834:Hydrazines; D001205:Ascorbic Acid