title: [Methemoglobin intoxication by prilocaine in EMLA. Accidental intoxication of an infant with scald injuries].
abstract: The case of an infant who had received EMLA(R) for local pain therapy after scalding to 5% of the body surface with boiling water is reported. Due to the application of EMLA(R) on the injured skin and exceeding the recommended doses of prilocaine and lidocaine the child developed symptomatic methemoglobinemia. During surgical wound dressing the boy showed cyanosis, decreased peripheral oxygen saturation and potentially suffered a general seizure. With a symptomatic therapy including mechanical ventilation and anticonvulsive drugs the methemoglobinemia normalized within 9 h. The child recovered without any neurological impairment after wound treatment was completed.
authors.affiliation: Zentrum für Anästhesie, Intensivtherapie und OP-Management, Klinikum Ernst von Bergmann, Charlottenstr.72, 14467 Potsdam, Deutschland. abook@klinikumevb.de
authors.forename: A
authors.initials: A
authors.lastname: Book
authors.forename: C
authors.initials: C
authors.lastname: Fehlandt
authors.forename: M
authors.initials: M
authors.lastname: Krija
authors.forename: M
authors.initials: M
authors.lastname: Radke
authors.forename: D
authors.initials: D
authors.lastname: Pappert
mesh_terms: D000287:Administration, Topical; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D001458:Bandages; D002056:Burns / Q000150:complications* / Q000188:drug therapy; D003490:Cyanosis / Q000097:blood / Q000139:chemically induced; D003937:Diagnosis, Differential; D006801:Humans; D007049:Iatrogenic Disease; D007223:Infant; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects*; D000077442:Lidocaine, Prilocaine Drug Combination; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000175:diagnosis; D009824:Ointments; D010100:Oxygen / Q000097:blood; D011318:Prilocaine / Q000008:administration & dosage / Q000009:adverse effects*; D012121:Respiration, Artificial; D014048:Tolonium Chloride
chemical_list: D000779:Anesthetics, Local; D000077442:Lidocaine, Prilocaine Drug Combination; D009824:Ointments; D011318:Prilocaine; D014048:Tolonium Chloride; D008012:Lidocaine; D010100:Oxygen