title: Regulation of p53 family members by the ubiquitin-like SUMO system.
abstract: p53 and its cousins p63 and p73 are critical regulators of the genotoxic stress response in mammalian cells. Their activity is controlled by an intricate network of post-translational modifications. The ubiquitin-like SUMO system targets all three family members and modulates their transcriptional activity, stability or subcellular trafficking. While the SUMO system appears to primarily exert a negative regulatory function on p73 and p63, both activating and repressing activities have been reported on p53. Here we will give a synopsis of the multifaceted effects of SUMO on p53 family members.
authors.affiliation: Department of Molecular Cell Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18, D-82152 Martinsried, Germany.
authors.forename: Per
authors.initials: P
authors.lastname: Stehmeier
authors.forename: Stefan
authors.initials: S
authors.lastname: Muller
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D055550:Protein Stability; D021381:Protein Transport; D025841:Small Ubiquitin-Related Modifier Proteins / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors; D015533:Transcriptional Activation; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D025841:Small Ubiquitin-Related Modifier Proteins; C115051:TP63 protein, human; C000606460:TP73 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins