title: Difference in tracer delay-induced effect among deconvolution algorithms in CT perfusion analysis: quantitative evaluation with digital phantoms.
abstract: Institutional review board approval and informed consent were obtained. The purpose was to evaluate the differences in tracer delay-induced effects of various deconvolution algorithms for computed tomographic (CT) perfusion imaging by using digital phantoms created from actual source data. Three methods of singular value decomposition (SVD) were evaluated. For standard SVD (sSVD), the delays induced significant errors in cerebral blood flow and mean transit time. In contrast, for block-circulant SVD (bSVD), these values remained virtually unchanged, whereas for delay-corrected SVD (dSVD), mild changes were observed. bSVD was superior to sSVD and dSVD for avoiding the tracer delay-induced effects in CT perfusion imaging.
authors.affiliation: Advanced Medical Research Center, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. kokudo@iwate-med.ac.jp
authors.forename: Kohsuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
authors.forename: Kuniaki
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Terae
authors.forename: Shigeru
authors.initials: S
authors.lastname: Ehara
authors.forename: Hiroki
authors.initials: H
authors.lastname: Shirato
mesh_terms: D000328:Adult; D000465:Algorithms; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism*; D002533:Cerebral Angiography / Q000295:instrumentation / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D019047:Phantoms, Imaging; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*
chemical_list: D003287:Contrast Media