title: Myocardial and aortal involvement in a case of disseminated infection with Fusarium solani after allogeneic stem cell transplantation: report of a case.
abstract: We describe a 57-year-old woman suffering from acute erythroblastic leukaemia. After the first course of high-dose Ara-C containing consolidation therapy, the patient developed multiple skin lesions on the left foot. A skin biopsy revealed a Fusarium infection. The lesions regressed under therapy with caspofungin and voriconazole. Leukaemia relapsed after 1 year and an allogeneic stem cell transplantation was performed for consolidation of leukaemia in second remission. Again, the patient developed macular skin lesions located on the trunk and the extremities with central pallor. Clinical examination showed fever, tachyarrhythmia and a systolic murmur. Fusarium spp. was cultured from blood samples. An antimycotic therapy with amphotericin B, voriconazole and posaconazole failed completely. The patient died in a septic shock with consecutive multiple organ failure. The autopsy (SN 1/06, Institute of Pathology, University of Greifswald) revealed a disseminated infiltration with Fusarium solani including myocardial, endocardial and aortal infection. The involvement of the cardiovascular system is uncommon in fusariosis and has not been described so far. This case confirms other reports describing the high mortality of fusariosis after allogeneic stem cell transplantation. A rapid diagnosis and antimycotics with higher activity against Fusarium spp. are necessary for successful therapy of this severe mould infection in the immunocompromised host.
authors.affiliation: Department of Hematology and Oncology, University Medical Center, Ernst-Moritz-Arndt-University, Greifswald, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Busemann
authors.forename: William
authors.initials: W
authors.lastname: Krüger
authors.forename: Günther
authors.initials: G
authors.lastname: Schwesinger
authors.forename: Bianca
authors.initials: B
authors.lastname: Kallinich
authors.forename: Gudrun
authors.initials: G
authors.lastname: Schröder
authors.forename: Peter
authors.initials: P
authors.lastname: Abel
authors.forename: Thomas
authors.initials: T
authors.lastname: Kiefer
authors.forename: Thomas
authors.initials: T
authors.lastname: Neumann
authors.forename: Gottfried
authors.initials: G
authors.lastname: Dölken
mesh_terms: D001011:Aorta / Q000382:microbiology; D053821:Cardiovascular Infections / Q000209:etiology / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D060585:Fusariosis / Q000209:etiology / Q000382:microbiology*; D005670:Fusarium / Q000302:isolation & purification* / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D014184:Transplantation, Homologous / Q000009:adverse effects*