The importance of steroidomics in the study of neurodegenerative disease and ageing.
In this mini review, the importance of experimental steroidomics in the study of neurodegenerative disease and aging is discussed. Attention is focused on just one class of lipid which is based on the cyclopentanoperhydro-phenanthrene ring system. Experimental methods for steroidomic analysis are reviewed, and the potential to use these methods to diagnose disease and to gain a better understanding of neurodegenerative disorders is examined.
Griffiths
William J
WJ
Institute of Mass Spectrometry, School of Medicine, Grove Building, Swansea University, Singleton Park, Swansea SA28PP, UK. w.j.griffiths@swansea.ac.uk
Wang
Yuqin
Y
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D006801:Humans; D006888:Hydroxycholesterols / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D007653:Ketocholesterols / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D013058:Mass Spectrometry / Q000379:methods*; D015394:Molecular Structure; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D013256:Steroids / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D006888:Hydroxycholesterols; D007653:Ketocholesterols; D013256:Steroids