title: Adjuvanted seasonal influenza vaccines and perpetual viral metamorphosis: the importance of cross-protection.
abstract: Vaccination is considered the most effective means of reducing influenza burden, providing substantial benefits in terms of reduction of morbidity, complications, hospitalizations and deaths, even if vaccines have been associated with a reduced immune response and lower effectiveness in older adults, in particular when a mismatch between the vaccine and the circulating virus strains occurred. Several strategies have been proposed to enhance vaccine protection against drifted strains, including the use of adjuvants. Among oil-emulsion adjuvants, MF-59 was approved for human use more than a decade ago and it is largely used for adjuvantation of influenza vaccine. Recent studies have demonstrated that addition of the MF-59 to subunit influenza vaccine can lead to higher haemagglutination-inhibiting seroprotection rates and to higher neutralization antibody titers against drifted strains not included in the vaccine respect to non-adjuvanted vaccine. Promising results were obtained using a new generation of oil-in-water emulsion adjuvants, named AS, offering cross-protection against heterologous challenge in ferrets.
authors.affiliation: Department of Health Sciences, University of Genoa - CIRI-IV, Inter-University Research Centre on Influenza, Via Pastore 1, 16132 Genoa, Italy. filippo.ansaldi@unige.it
authors.forename: Filippo
authors.initials: F
authors.lastname: Ansaldi
authors.forename: Paola
authors.initials: P
authors.lastname: Canepa
authors.forename: Valentina
authors.initials: V
authors.lastname: Parodi
authors.forename: Sabrina
authors.initials: S
authors.lastname: Bacilieri
authors.forename: Andrea
authors.initials: A
authors.lastname: Orsi
authors.forename: Federica
authors.initials: F
authors.lastname: Compagnino
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Icardi
authors.forename: Paolo
authors.initials: P
authors.lastname: Durando
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000914:Antibodies, Viral / Q000097:blood; D006801:Humans; D007252:Influenza Vaccines / Q000276:immunology*; D009500:Neutralization Tests; D009975:Orthomyxoviridae / Q000145:classification / Q000276:immunology*; D011136:Polysorbates / Q000008:administration & dosage*; D013185:Squalene / Q000008:administration & dosage*; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007252:Influenza Vaccines; C089950:MF59 oil emulsion; D011136:Polysorbates; D013185:Squalene