title: Dendritic cell sarcomas/tumours of the breast: report of two cases.
abstract: Extranodal follicular dendritic cell sarcoma/tumours (FDCS/Ts) and interdigitating dendritic cell sarcoma/tumours (IDCS/Ts) are rare neoplasms. We present two cases of FDCS/T and IDCS/T of the breast. The FDCS/T case (case 1) presented in a 31-year-old woman and the IDCS/T case (case 2) in a 67-year-old woman who both showed a firm lump in the left breast. The FDCS/T lesion superficially appeared as an anaplastic carcinoma and the IDCS/T was reminiscent of a spindle cell sarcomatoid carcinoma. Nevertheless both lesions were negative for keratins while case 1 displayed neoplastic cells strongly positive for CD21, vimentin and focally for CD68 and S-100 protein. The tumour cells of case 2 were positive for S-100, CD68 and CD45. In breast, an unusual keratin negative tumour composed predominantly of spindle cells arranged in fascicles, storiform pattern or whorls with a lymphoid rich stroma should raise suspicion for FDCS/Ts or IDCS/Ts. The distinction from malignant tumours with similar features is discussed.
authors.affiliation: Department of Pathology, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Nilgun
authors.initials: N
authors.lastname: Kapucuoglu
authors.forename: Sibel
authors.initials: S
authors.lastname: Percinel
authors.forename: Terenzio
authors.initials: T
authors.lastname: Ventura
authors.forename: RongGang
authors.initials: R
authors.lastname: Lang
authors.forename: Wael
authors.initials: W
authors.lastname: Al-Daraji
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Eusebi
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000096:biosynthesis; D015214:Antigens, Differentiation, Myelomonocytic / Q000096:biosynthesis; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D054740:Dendritic Cell Sarcoma, Follicular / Q000378:metabolism* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D017493:Leukocyte Common Antigens / Q000096:biosynthesis; D008408:Mastectomy; D017464:Receptors, Complement 3d / Q000096:biosynthesis; D009418:S100 Proteins / Q000096:biosynthesis; D014746:Vimentin / Q000096:biosynthesis; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D017493:Leukocyte Common Antigens; D017464:Receptors, Complement 3d; D009418:S100 Proteins; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule