Airway malacia in chronic obstructive pulmonary disease: prevalence, morphology and relationship with emphysema, bronchiectasis and bronchial wall thickening.
The aim of this study was to determine the prevalence of airway malacia and its relationship with ancillary morphologic features in patients with chronic obstructive pulmonary disease (COPD). A retrospective review was performed of a consecutive series of patients with COPD who were imaged with inspiratory and dynamic expiratory multidetector computed tomography (MDCT). Airway malacia was defined as > or =50% expiratory reduction of the airway lumen. Both distribution and morphology of airway malacia were assessed. The extent of emphysema, extent of bronchiectasis and severity of bronchial wall thickness were quantified. The final study cohort was comprised of 71 patients. Airway malacia was seen in 38 of 71 patients (53%), and such proportion was roughly maintained in each stage of COPD severity. Almost all tracheomalacia cases (23/25, 92%) were characterised by an expiratory anterior bowing of the posterior membranous wall. Both emphysema and bronchiectasis extent did not differ between patients with and without airway malacia (p > 0.05). Bronchial wall thickness severity was significantly higher in patients with airway malacia and correlated with the degree of maximal bronchial collapse (p < 0.05). In conclusion, we demonstrated a strong association between airway malacia and COPD, disclosing a significant relationship with bronchial wall thickening.
Sverzellati
Nicola
N
Department of Clinical Sciences, Section of Radiology, University of Parma, Ospedale Maggiore di Parma, Padiglione Barbieri, V. Gramsci 14, 43100, Parma, Italy. nicolasve@tiscali.it
Rastelli
Andrea
A
Chetta
Alfredo
A
Schembri
Valentina
V
Fasano
Luca
L
Pacilli
Angela Maria
AM
Di Scioscio
Valerio
V
Bartalena
Tommaso
T
De Filippo
Massimo
M
Zompatori
Maurizio
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001317:Austria / Q000453:epidemiology; D001987:Bronchiectasis / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D001995:Bronchography; D015897:Comorbidity; D004646:Emphysema / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive; D014133:Tracheal Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology*