title: Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.
abstract: Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27.
authors.affiliation: SCYNEXIS, Inc., Discovery Chemistry, PO Box 12878, Research Triangle Park, NC 27709-2878, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Scribner
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Moore
authors.forename: Gilles
authors.initials: G
authors.lastname: Ouvry
authors.forename: Michael
authors.initials: M
authors.lastname: Fisher
authors.forename: Matthew
authors.initials: M
authors.lastname: Wyvratt
authors.forename: Penny
authors.initials: P
authors.lastname: Leavitt
authors.forename: Paul
authors.initials: P
authors.lastname: Liberator
authors.forename: Anne
authors.initials: A
authors.lastname: Gurnett
authors.forename: Chris
authors.initials: C
authors.lastname: Brown
authors.forename: John
authors.initials: J
authors.lastname: Mathew
authors.forename: Donald
authors.initials: D
authors.lastname: Thompson
authors.forename: Dennis
authors.initials: D
authors.lastname: Schmatz
authors.forename: Tesfaye
authors.initials: T
authors.lastname: Biftu
mesh_terms: D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000201:enzymology / Q000469:parasitology; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000494:pharmacology; D017869:Cyclic GMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D016786:Eimeria tenella / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011200:Poultry / Q000469:parasitology; D011725:Pyridines / Q000138:chemical synthesis
chemical_list: D003049:Coccidiostats; D007211:Indoles; D011725:Pyridines; D017869:Cyclic GMP-Dependent Protein Kinases; C023666:pyridine