title: Deadly splicing: Bax becomes Almighty.
abstract: Activation of Bax and Bak by BH3-only molecules triggers mitochondrial apoptosis. In a recent issue of Molecular Cell, Fu et al. (2009) identify a constitutively active isoform of Bax, Baxbeta, whose activity is tightly controlled by the ubiquitin-proteasome system.
authors.affiliation: Molecular Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Hyungjin
authors.initials: H
authors.lastname: Kim
authors.forename: James J-D
authors.initials: JJ
authors.lastname: Hsieh
authors.forename: Emily H-Y
authors.initials: EH
authors.lastname: Cheng
mesh_terms: D017398:Alternative Splicing / Q000502:physiology*; D017209:Apoptosis; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
chemical_list: D020033:Protein Isoforms; D014452:Ubiquitins; D051028:bcl-2-Associated X Protein; D046988:Proteasome Endopeptidase Complex