Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy.
We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.
Mignatti
Andrea
A
Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA.
Sims
Daniel B
DB
Colombo
Paolo C
PC
Garcia
Luis I
LI
Bijou
Rachel
R
Deng
Mario C
MC
Jorde
Ulrich P
UP
D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005080:Exercise Test; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D015415:Biomarkers; D009638:Norepinephrine