title: Analysis of growth factor expression in affected and unaffected muscles of oculo-pharyngeal muscular dystrophy (OPMD) patients: a pilot study.
abstract: Oculo-pharyngeal muscular dystrophy (OPMD) is characterised by progressive eyelid drooping (ptosis) and difficulties with swallowing (dysphagia). In order to determine the role of growth factors, cytokines and chemokines in the physiopathology of muscle disease we have compared the level of expression of 174 factors in both the affected (cricopharyngeal) and non-affected (sternocleidomastoid) muscles of 8 OPMD patients by means of antibody arrays. Despite an important inter-individual variability the expression of sixty factors was found to be persistently different between affected and non-affected muscles. Many of the differentially expressed factors in our study are known to be involved in the formation of fibrosis in both the liver and the lung, indicating the possibility that treatments such as those used in hepatic fibrosis may have a beneficial effect in OPMD patients.
authors.affiliation: UPMC, Université Pierre et Marie Curie Paris VI, Institut de Myologie, 105, Bd de l'Hôpital, 75634 Paris, France.
authors.forename: Belaid
authors.initials: B
authors.lastname: Bouazza
authors.forename: Gueorgui
authors.initials: G
authors.lastname: Kratassiouk
authors.forename: Bernard
authors.initials: B
authors.lastname: Gjata
authors.forename: Sophie
authors.initials: S
authors.lastname: Perie
authors.forename: Jean
authors.initials: J
authors.lastname: Lacau St Guily
authors.forename: Gillian S
authors.initials: GS
authors.lastname: Butler-Browne
authors.forename: Fedor
authors.initials: F
authors.lastname: Svinartchouk
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000032:analysis / Q000378:metabolism; D018925:Chemokines / Q000032:analysis / Q000378:metabolism; D019295:Computational Biology / Q000379:methods; D016207:Cytokines / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005355:Fibrosis / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D039141:Muscular Dystrophy, Oculopharyngeal / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D010865:Pilot Projects; D040081:Protein Array Analysis / Q000379:methods; D040901:Proteomics / Q000379:methods; D012984:Software
chemical_list: D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D036341:Intercellular Signaling Peptides and Proteins