title: Tumour necrosis factor alpha gene (TNF-alpha) -376 polymorphism in Hungarian patients with primary progressive multiple sclerosis.
abstract: Tumour necrosis factor alpha (TNF-alpha) is associated with clinical activity in relapsing-remitting multiple sclerosis (RRMS) and the development of progressive disease. Our aim was to investigate the TNF-alpha -376 polymorphism in primary progressive MS (PPMS) patients. Polymerase chain reaction and restriction fragment length polymorphism were carried out on 45 PPMS patients, 45 age and sex-matched RRMS patients and 45 healthy controls (HC). The GG genotype and the guanine allele (G) were detected significantly more often in the PPMS group as compared with the HC group (p=0.027; p=0.032). The G allele may be one of the factors responsible for progression in PPMS.
authors.affiliation: Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Szeged, Hungary.
authors.forename: Erika
authors.initials: E
authors.lastname: Losonczi
authors.forename: Krisztina
authors.initials: K
authors.lastname: Bencsik
authors.forename: Zsanett Fricska
authors.initials: ZF
authors.lastname: Nagy
authors.forename: Viktor
authors.initials: V
authors.lastname: Honti
authors.forename: Estilla
authors.initials: E
authors.lastname: Szalczer
authors.forename: Cecília
authors.initials: C
authors.lastname: Rajda
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Illés
authors.forename: Klotild
authors.initials: K
authors.lastname: Mátyás
authors.forename: Csilla
authors.initials: C
authors.lastname: Rózsa
authors.forename: Tünde
authors.initials: T
authors.lastname: Csépány
authors.forename: Judit
authors.initials: J
authors.lastname: Füvesi
authors.forename: László
authors.initials: L
authors.lastname: Vécsei
mesh_terms: D000225:Adenine; D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006147:Guanine; D006801:Humans; D006814:Hungary; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D006147:Guanine; D000225:Adenine