title: Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature.
abstract: Mucoepidermoid carcinoma of the breast is a rare entity with specific morphologic and immunohistochemical features similar to its salivary gland counterpart. In the 28 reported cases to date, there has not been a comparison of the molecular characteristics of this tumor with salivary gland mucoepidermoid carcinomas. Herein, a case of mucoepidermoid carcinoma of the breast with a molecular alteration similar to its salivary gland counterpart is reported. A lymph node metastasis was identified despite a predominantly in situ component and foci of microinvasion. The morphologic, immunohistochemical, prognostic, and molecular features are discussed.
authors.affiliation: Department of Surgery, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA.
authors.forename: Sandra I
authors.initials: SI
authors.lastname: Camelo-Piragua
authors.forename: Claudine
authors.initials: C
authors.lastname: Habib
authors.forename: Prathima
authors.initials: P
authors.lastname: Kanumuri
authors.forename: Claudia E
authors.initials: CE
authors.lastname: Lago
authors.forename: Holly S
authors.initials: HS
authors.lastname: Mason
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Otis
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000473:pathology*; D015534:Trans-Activators; D014157:Transcription Factors / Q000032:analysis
chemical_list: D004268:DNA-Binding Proteins; C471297:MAML2 protein, human; D009687:Nuclear Proteins; D015534:Trans-Activators; D014157:Transcription Factors