Intravitreal toxicity of ketorolac tris salt and flurbiprofen.
OBJECTIVE
To determine the retinal toxicity of intravitreal ketorolac tris salt and flurbiprofen.


METHODS
Thirty-two New Zealand rabbits were injected intravitreally with 125, 250, or 500 microg or 1 mg of ketorolac tris salt or flurbiprofen in one eye and 8 fellow eyes were injected with 5% dextrose as a control. All animals underwent indirect ophthalmoscopy and slit-lamp biomicroscopy before injection and on days 1, 7, and 14 after the intravitreal injection. Electroretinography was performed on all animals before injection and on day 14 after the injection before the animals were killed. The enucleated eyes were prepared for histology.


RESULTS
Clinical examination, electroretinography results, and histological evaluation demonstrated no signs of retinal toxicity for either drug at any dose.


CONCLUSIONS
Intravitreal doses up to 1 mg of ketorolac tris salt and 1 mg of flurbiprofen did not cause retinal toxicity in the rabbit eye.
Morales
Ana Munoz
AM
Department of Ophthalmology, Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
Kivilcim
Muhamet
M
Peyman
Gholam A
GA
Main
Muhammad
M
Manzano
Roberta Pereira de Almada
RP
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D016861:Cyclooxygenase Inhibitors / Q000633:toxicity*; D004596:Electroretinography; D005480:Flurbiprofen / Q000633:toxicity*; D020911:Ketorolac Tromethamine / Q000633:toxicity*; D009887:Ophthalmoscopy; D011817:Rabbits; D012160:Retina / Q000187:drug effects* / Q000503:physiopathology; D014822:Vitreous Body / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D020911:Ketorolac Tromethamine; D005480:Flurbiprofen