title: Easy to diagnose, difficult to treat: keratosis lichenoides chronica.
abstract: Keratosis lichenoides chronica (KLC) is a rare disease, with approximately 70 cases reported in the literature. The problem in this long-lasting disease is generally the treatment, not the diagnosis. In the literature, many treatments failed to show any beneficial effect. We present a 20-year-old man with KLC that was successfully treated with a combination of phototherapy, acitretin and calcipotriol ointment. The patient's lesions showed a marked improvement with this combination. To our knowledge, this is the first report of this type of combination treatment being used successfully in KLC. This approach might help reduce doses of retinoids or psoralen ultraviolet A required when these are used separately, and limit the potential toxicity of these treatments.
authors.affiliation: Departments of Dermatology, Gazi University Faculty of Medicine, Ankara, Turkey. eozsoy@gazi.edu.tr
authors.forename: E
authors.initials: E
authors.lastname: Adişen
authors.forename: O
authors.initials: O
authors.lastname: Erdem
authors.forename: S
authors.initials: S
authors.lastname: Celepçi
authors.forename: M A
authors.initials: MA
authors.lastname: Gürer
mesh_terms: D017255:Acitretin / Q000627:therapeutic use*; D000279:Administration, Cutaneous; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002908:Chronic Disease; D003131:Combined Modality Therapy / Q000379:methods; D003879:Dermatologic Agents / Q000627:therapeutic use*; D006801:Humans; D007642:Keratosis / Q000188:drug therapy / Q000473:pathology*; D017512:Lichenoid Eruptions / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D010789:Phototherapy / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol; D017255:Acitretin