title: Cyclodextrins improve the antimicrobial activity of the chloride salt of Ruthenium(II) chloro-phenanthroline-trithiacyclononane.
abstract: The complex [Ru([9]aneS(3))phenCl]Cl (phen = 1,10-phenanthroline) and its synthetic precursor [Ru([9]aneS(3))dmsoCl(2)] were immobilized in permethylated beta-cyclodextrin (TRIMEB). A new crystalline structure of the precursor, obtained from a batch ethanol solution at low temperature (4 degrees C), is fully described from single-crystal X-ray diffraction data. [Ru([9]aneS(3))phenCl]Cl was also encapsulated in native beta-cyclodextrin for comparison with the TRIMEB compound. All three compounds were obtained with a 1:1 host:guest stoichiometry and were studied by powder X-ray diffraction (including synchrotron radiation data), thermogravimetric analysis (TGA), (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The bacterial growth inhibitory action of the complex [Ru([9]aneS(3))phenCl]Cl and its two cyclodextrin compounds was tested on Gram-negative (Salmonella, Escherichia) and Gram-positive strains (Bacillus, Listeria, Enterococcus and Staphilococcus) and results show a positive effect of cyclodextrin immobilization on the antimicrobial properties.
authors.affiliation: Departamento de Química, CICECO, Universidade de Aveiro, 3810-193 Aveiro, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Marques
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Braga
authors.forename: Filipe A
authors.initials: FA
authors.lastname: Almeida Paz
authors.forename: Teresa M
authors.initials: TM
authors.lastname: Santos
authors.forename: Maria
authors.initials: M
authors.lastname: de Fátima Silva Lopes
authors.forename: Susana S
authors.initials: SS
authors.lastname: Braga
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001407:Bacillus / Q000187:drug effects; D003505:Cyclodextrins / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects; D004925:Escherichia / Q000187:drug effects; D008087:Listeria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010618:Phenanthrolines / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D012475:Salmonella / Q000187:drug effects; D017550:Spectroscopy, Fourier Transform Infrared; D013210:Staphylococcus / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D000890:Anti-Infective Agents; D003505:Cyclodextrins; D010618:Phenanthrolines; D017975:Ruthenium Compounds