T cell acute lymphoblastic leukemia: NOTCHing the way toward a better treatment outcome.
Gamma-secretase inhibitors block the activation of NOTCH1 but have limited activity against T cell acute lymphoblastic leukemia (T-ALL) and cause severe gastrointestinal toxicity. In a recent study, Real et al. show that a potent gamma-secretase inhibitor potentiates the cytotoxicity of dexamethasone against glucocorticoid-resistant T-ALL cells, while dexamethasone abrogates the gastrointestinal toxicity induced by the gamma-secretase inhibitor.
Pui
Ching-Hon
CH
Department of Oncology, St Jude Children's Research Hospital and the University of Tennessee Health Science Center, Memphis, TN 38105, USA. ching-hon.pui@stjude.org
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors; D003907:Dexamethasone / Q000627:therapeutic use*; D006801:Humans; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000503:physiopathology; D051881:Receptor, Notch1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D051881:Receptor, Notch1; D003907:Dexamethasone; D053829:Amyloid Precursor Protein Secretases