title: Blastocyst environment and its influence on offspring cardiovascular health: the heart of the matter.
abstract: The development of adult-onset diseases such as type II diabetes, obesity and cardiovascular disease is traditionally attributed to adult lifestyle characteristics such as a lack of physical exercise, poor diet and smoking. However, evidence from both human and animal model studies has demonstrated that environmental factors such as an imbalance or reduction in maternal nutrition during gestation can have adverse effects on offspring metabolism and cardiovascular health. The severity and nature of the phenotypic changes induced in offspring is influenced by the period of gestation manipulated. In particular, the mammalian preimplantation embryo in different animal models displays particular sensitivity to environmental factors, either in vivo (maternal diet) or in vitro (embryo culture) that is associated with the onset of cardiovascular dysfunction in adult life. The detailed mechanisms by which environmental conditions can alter postnatal cardiovascular physiology are poorly understood. However, various factors including endothelial function, vascular responsiveness, the renin-angiotensin system, kidney structure and early postnatal growth dynamics have all been recognize as potential contributors. Here, we review the relationship between preimplantation embryo environment and postnatal cardiovascular disease risk, and consider biochemical, molecular, genetic and physiological pathways implicated in this association.
authors.affiliation: School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, UK.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Watkins
authors.forename: Tom P
authors.initials: TP
authors.lastname: Fleming
mesh_terms: D001755:Blastocyst / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000196:embryology*; D004777:Environment; D005260:Female; D047109:Fetal Development / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000196:embryology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D039401:Prenatal Nutritional Physiological Phenomena / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D046509:Tissue Culture Techniques