Mucoepidermoid carcinoma of the breast shares cytogenetic abnormality with mucoepidermoid carcinoma of the salivary gland: a case report with molecular analysis and review of the literature.
Mucoepidermoid carcinoma of the breast is a rare entity with specific morphologic and immunohistochemical features similar to its salivary gland counterpart. In the 28 reported cases to date, there has not been a comparison of the molecular characteristics of this tumor with salivary gland mucoepidermoid carcinomas. Herein, a case of mucoepidermoid carcinoma of the breast with a molecular alteration similar to its salivary gland counterpart is reported. A lymph node metastasis was identified despite a predominantly in situ component and foci of microinvasion. The morphologic, immunohistochemical, prognostic, and molecular features are discussed.
Camelo-Piragua
Sandra I
SI
Department of Surgery, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA 01199, USA.
Habib
Claudine
C
Kanumuri
Prathima
P
Lago
Claudia E
CE
Mason
Holly S
HS
Otis
Christopher N
CN
D001943:Breast Neoplasms / Q000235:genetics / Q000473:pathology*; D018277:Carcinoma, Mucoepidermoid / Q000235:genetics / Q000473:pathology*; D004268:DNA-Binding Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008875:Middle Aged; D009687:Nuclear Proteins / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000235:genetics / Q000473:pathology*; D015534:Trans-Activators; D014157:Transcription Factors / Q000032:analysis
D004268:DNA-Binding Proteins; C471297:MAML2 protein, human; D009687:Nuclear Proteins; D015534:Trans-Activators; D014157:Transcription Factors