[Surgical site infection in pancreas surgery and the use of perioperative antibiotics].
OBJECTIVE
To analyze the pathogen profiles and the use of perioperative antibiotics after surgical site infection (SSI) in pancreas operation.


METHODS
We retrospectively analyzed the pathogen profiles and the use of perioperative antibiotics in 48 SSI patients who received pancreas operations from Jan 2001 to Dec 2005.


RESULTS
Totally 79 strains of pathogens (74 strains of bacteria) were isolated, including 17 strains of methicillin-resistant Staphylococcus aureus (MRSA), 17 strains of enterococcus species, 12 strains of Escherichia species, and 5 strains of enterobacteriaceae. Combination of the third generation of cephalosporins and antianaerobic agents were the main prophylactic therapies, with an average duration of (4.7 +/- 1.2) days. Most SSI episodes happened 6-14 days postoperatively (median 9 days). Celiac infections were most common (n=39). Therapeutic antibiotics gave priority to combined-antibiotics of the third cephalosporins and antianaerobic antibiotics, glycopeptides and carbapenems.


CONCLUSIONS
SSI commonly occurs on the 6-14 postoperative day, with MRSA and enterococci as the common pathogens of SSI after pancreas surgery. Antibiotic resistance should be considered when applying prophylactic therapies.
Wang
Ai
A
Hospital-acquired Infection Control Office, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhou
Jiong
J
Ma
Xiao-Jun
XJ
Dong
Li-li
LL
Li
Gui-ping
GP
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D004352:Drug Resistance, Microbial; D006801:Humans; D019990:Perioperative Care; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*; D013997:Time Factors
D000900:Anti-Bacterial Agents