title: In vitro activities of fluconazole and voriconazole against clinical isolates of Candida spp. determined by disk diffusion testing in Turin, Italy.
abstract: The in vitro activities of fluconazole and voriconazole against 1,024 clinical isolates of Candida spp. were determined by the agar disk diffusion test using the Clinical and Laboratory Standards Institute (CLSI) M44-A guidelines. The results of this investigation demonstrated the broad-spectrum in vitro activity of voriconazole, relative to that of fluconazole, against yeasts tested, in particular fluconazole-resistant isolates, such as Candida krusei that showed high susceptibility to voriconazole. The situation in Turin, Italy, is quite similar to that of the rest of Italy, reflecting the worldwide trend.
authors.affiliation: Department of Public Health and Microbiology, University of Turin, Turin, Italy.
authors.forename: Narcisa
authors.initials: N
authors.lastname: Mandras
authors.forename: Vivian
authors.initials: V
authors.lastname: Tullio
authors.forename: Valeria
authors.initials: V
authors.lastname: Allizond
authors.forename: Daniela
authors.initials: D
authors.lastname: Scalas
authors.forename: Giuliana
authors.initials: G
authors.lastname: Banche
authors.forename: Janira
authors.initials: J
authors.lastname: Roana
authors.forename: Francesca
authors.initials: F
authors.lastname: Robbiano
authors.forename: Giacomo
authors.initials: G
authors.lastname: Fucale
authors.forename: Aurelio
authors.initials: A
authors.lastname: Malabaila
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Cuffini
authors.forename: Nicola
authors.initials: N
authors.lastname: Carlone
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D004058:Diffusion; D015725:Fluconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods*; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D015725:Fluconazole; D065819:Voriconazole