title: Ring-opening metathesis polymerization-based synthesis of ICG-containing amphiphilic triblock copolymers for in vivo tumor imaging.
abstract: Water-soluble triblock copolymers consisting of hydrophobic-hydrophilic-dye segments were synthesized by ring-opening metathesis polymerization (ROMP) of norbornadiene monomers, copper-catalyzed click reaction, osmium-catalyzed dihydroxylation, and the following transformations. These polymers in aqueous conditions could form spherical assemblies, whose diameters were 50-60 nm by TEM measurement. From in vivo optical imaging experiments, the spherical assemblies of these copolymers could be efficiently accumulated in tumor cells. In addition, the spherical assemblies of water-soluble polymers accumulated in a tumor cell over two weeks.
authors.affiliation: Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Miki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kuramochi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Oride
authors.forename: Satoru
authors.initials: S
authors.lastname: Inoue
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Harada
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ohe
mesh_terms: D000818:Animals; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009369:Neoplasms / Q000175:diagnosis*; D009636:Norbornanes / Q000138:chemical synthesis / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D019265:Spectroscopy, Near-Infrared / Q000379:methods
chemical_list: D009636:Norbornanes; D011108:Polymers