[Hemolytic-uremic syndrome: what is the mechanism?].
Many data suggest that improper regulation of the alternative complement pathway is involved in the pathophysiology of atypical hemolytic-uremic syndrome. Until a few years ago, research exclusively focused on protein assays, which did not help to identify precise genetic factors predisposing to atypical hemolytic-uremic syndrome. In this context, the introduction of gene study considerably accelerated advances.
Fremeaux-Bacchi
Véronique
V
Service d'immunologie biologique, hôpital Européen Georges-Pompidou, 75908 Paris Cedex 15. veronique.fremeaux-bacchi@egp.aphp.fr
Fakhouri
Fadi
F
Loirat
Chantal
C
D020022:Genetic Predisposition to Disease; D006463:Hemolytic-Uremic Syndrome / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D051916:Membrane Cofactor Protein / Q000235:genetics
C497857:CD46 protein, human; D051916:Membrane Cofactor Protein