Comparison of multislice computed tomography angiography and digital subtraction angiography in the detection of residual or recurrent aneurysm after surgical clipping with titanium clips.
OBJECTIVE
To determine the diagnostic accuracy of 3D-CTA using volume rendering (VR) in the detection of residual or recurrent cerebral aneurysms after clipping.


METHODS
Between January 2006 and November 2007, 45 patients (20 female, 25 male) with 50 intracranial aneurysms treated using titanium clips were enrolled in this study. IADSA and 3D-CTA were performed within 1 month after surgery in 27 (60%) patients, after 1 year in 12 (26%) patients and after 5 years in six (13%) patients. In blinded fashion, CTA and DSA images were independently interpreted by two senior neuroradiologists with 7 years of experience in vascular diagnostic neuroradiology. The diagnostic performance of MDCTA compared with DSA for the detection of aneurysm remnants was measured by receiver operating characteristic (ROC) analysis. The area under the ROC curve, 95% confidence interval (CI), sensitivity, and specificity were calculated.


RESULTS
For the detection of residue-recurrent aneurysm; the sensitivity and specificity of MDCTA were 87.5% (95% CI = 52.9-97.8%) and 97.4% (95% CI = 86.5-99.5%) for the first reader and 87.5% (95% CI = 52.9-97.8%) and 100% (95% CI = 90.8-100%) for the second reader respectively. Receiver operating characteristic (ROC) analysis revealed good diagnostic performance for 3D-CTA (mean area under ROC curve (Az) = 0.98 and 0.99 for the first and the second observer, respectively) The kappa values extracted from the interobserver concordance analysis for agreement observers regarding the use of MDCTA for assessment of a remnant neck was 0.62.


CONCLUSIONS
Using MDCTA, it is possible to demonstrate the status of intracranial aneurysms after surgical clipping in the immediate postoperative period as well as long-term follow-up with an high sensitivity and specificity when comparing with the findings of DSA.
Uysal
Ender
E
Department of Radiology, Sisli Etfal Training and Research Hospital, Sisli, Istanbul, Turkey. enderuysaltr@yahoo.com
Ozel
Alper
A
Erturk
Sukru Mehmet
SM
Kirdar
Onder
O
Basak
Muzaffer
M
D000328:Adult; D015901:Angiography, Digital Subtraction / Q000379:methods* / Q000706:statistics & numerical data; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000517:prevention & control / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control; D011237:Predictive Value of Tests; D055502:Secondary Prevention; D013525:Surgical Instruments / Q000706:statistics & numerical data; D014025:Titanium / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000706:statistics & numerical data; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures / Q000295:instrumentation / Q000379:methods
D014025:Titanium