Testosterone treatment in elderly men.
Testosterone has been used in testicular and hypothalamo-pituitary diseases since the 1940s. There is growing interest in the use of testosterone in aging men, and this has stimulated research into the benefits of male hormone replacement. Testosterone treatment of men with hypogonadism might have beneficial effects on body composition, muscle strength, sexual function, and cognition. There are several modes of administration of the male hormone, with injectable testosterone esters and implanted testosterone pellets being the mainstay of treatment until recently. These preparations are increasingly being replaced by transdermal patches, gels, and long-acting parenteral preparations. Testosterone patches and gels are ideally for elderly men. Treatment with the male hormone is relatively safe, if patients are selected appropriately and monitored carefully. The most important adverse effects are on the prostate. In this review, we briefly discuss the indications, contraindications, and benefits of testosterone treatment. Further, we list the adverse effects, advantages, and disadvantages of various testosterone preparations in elderly men.
Srinivas-Shankar
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Department of Diabetes and Endocrinology, The Royal Liverpool and Broadgreen University, Hospitals NHS Trust, Liverpool, L78XP, UK. usrinivas@manchester.ac.uk
Sharma
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D
D000339:Affect / Q000187:drug effects; D000368:Aged; D000375:Aging / Q000502:physiology; D000728:Androgens / Q000009:adverse effects / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D000075202:Contraindications; D004333:Drug Administration Routes; D016503:Drug Delivery Systems; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D008297:Male; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy; D013739:Testosterone / Q000009:adverse effects / Q000627:therapeutic use*
D000728:Androgens; D013739:Testosterone