Fatal Epstein-Barr virus primo infection in a 25-year-old man treated with azathioprine for Crohn's disease.
We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specific EBV-related clinical and virological management should be considered when treating a patient with inflammatory bowel disease with azathioprine.
N'guyen
Y
Y
Service de Médicine Interne et des Maladies Infectieuses, Hôpital Robert Debré-CHU Reims, Reims, France.
Andreoletti
L
L
Patey
M
M
Lecoq-Lafon
C
C
Cornillet
P
P
Léon
A
A
Jaussaud
R
R
Fieschi
C
C
Strady
C
C
D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
D007166:Immunosuppressive Agents; D001379:Azathioprine