title: Enzyme- and ruthenium-catalyzed dynamic kinetic asymmetric transformation of 1,5-diols. Application to the synthesis of (+)-Solenopsin A.
abstract: Dynamic kinetic asymmetric transformation (DYKAT) of 1,5-diols via combined lipase and ruthenium catalysis provides enantiomerically pure diacetates in high diastereoselectivity, which can serve as intermediates in natural product synthesis. This is demonstrated by the synthesis of (+)-Solenopsin A.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: Karin
authors.initials: K
authors.lastname: Leijondahl
authors.forename: Linnéa
authors.initials: L
authors.lastname: Borén
authors.forename: Roland
authors.initials: R
authors.lastname: Braun
authors.forename: Jan-E
authors.initials: JE
authors.lastname: Bäckvall
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007700:Kinetics; D008049:Lipase / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000470:Alkaloids; C002351:Solenopsin A; D012428:Ruthenium; D008049:Lipase