title: [Expression of adenylate kinases 2 in the brains of patients with refractory temporal epilepsy].
abstract: OBJECTIVE
  To study the protein expression of adenylate kinases (AK)-2 in the brain tissues of patients with drug-refractory temporal epilepsy and the clinical value thereof.
  
  
  METHODS
  Specimens of brain from 40 patients with refractory temporal epilepsy, and 20 sex- and age-matched persons with brain trauma. Immunohistochemistry and immunofluorescence examination were used to test the levels of AK2.
  
  
  RESULTS
  AK2 was expressed in the temporal lobes and hippocampuses of all epileptics, mainly in the cell bodies, and not in the brain tissues of the controls.
  
  
  CONCLUSIONS
  The overexpression of AK2 may be involved in the pathogenesis of drug-refractory epilepsy and become an important symbol thereof.
authors.affiliation: Department of Neurology, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zeng
authors.forename: Xue-Feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
mesh_terms: D000263:Adenylate Kinase / Q000378:metabolism*; D000328:Adult; D017209:Apoptosis; D001921:Brain / Q000378:metabolism*; D004351:Drug Resistance; D004827:Epilepsy / Q000378:metabolism*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D007527:Isoenzymes; D000263:Adenylate Kinase; C110938:adenylate kinase 2