title: Chronologic change of the maximum dimension of Bacillus Calmette-Guerin-induced keloids.
abstract: BACKGROUND
  Because keloids grow gradually, there is a long time lag until the patients visit the hospital.
  
  
  OBJECTIVE
  To investigate the chronologic change of the maximum dimension of Bacillus Calmette-Guerin (BCG)-induced keloids to provide information on their nature and facilitate early treatment intervention.
  
  
  METHODS
  Clinical records of patients with keloid treated between 1998 and 2005 were reviewed, and patients with BCG-induced keloids were assessed with reference to age at onset of keloid, age at first hospital visit, length of the major axis of keloid at first visit, growth rate, and histopathologic features.
  
  
  RESULTS
  Of 716 patients with keloid, 60 (8.4%) had BCG-induced keloid. A significant difference was found between mean age at onset and at first visit. The mean length of maximum dimension was 42.4 mm and increased proportionally to age at first visit. Keloids grew rapidly between the ages of 20 and 40, during which time many patients did not seek therapy. Histopathologically, no significant differences were noted between BCG-induced keloid and non-BCG keloid.
  
  
  CONCLUSIONS
  Early therapeutic intervention might prevent keloids from growing larger, emphasizing a need to provide adequate information on keloid behavior to patients and physicians involved in BCG vaccination.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Musashi-kosugi Hospital, Nippon Medical School, Kawasaki, Japan. tosa-m@nms.ac.jp
authors.forename: Mamiko
authors.initials: M
authors.lastname: Tosa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Murakami
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ghazizadeh
authors.forename: Hiko
authors.initials: H
authors.lastname: Hyakusoku
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001500:BCG Vaccine / Q000009:adverse effects*; D002648:Child; D018450:Disease Progression; D005260:Female; D006801:Humans; D007627:Keloid / Q000139:chemically induced* / Q000453:epidemiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D001500:BCG Vaccine