The MLLgnant consequences of reverting to an embryonic transcriptional program.
In this issue of Cell Stem Cell, Somervaille et al. (2009) have demonstrated convincingly that reversion to an embryonic transcriptional program through defective MLL gene expression contributes to the generation of myeloid leukemia stem cells.
Jamieson
Catriona
C
Stem Cell Research Program, Division of Hematology/Oncology, Moores UCSD Cancer Center, University of California-San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA. cjamieson@ucsd.edu
D000818:Animals; D065150:Cellular Reprogramming; D018507:Gene Expression Regulation, Developmental; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology / Q000503:physiopathology; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000502:physiology*; D014158:Transcription, Genetic
C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase