Highly enantioselective hydrogenation of enamides catalyzed by chiral phosphoric acids.
A highly enantioselective hydrogenation of enamides catalyzed by a dual chiral-achiral acid system was developed. By employing a substoichiometric amount of a chiral phosphoric acid and acetic acid, catalyst loadings as low as 1 mol % of the chiral catalyst were sufficient to provide excellent yield and enantioselectivity of the reduction product.
Li
Guilong
G
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, USA.
Antilla
Jon C
JC
D000085:Acetates / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism
D000085:Acetates; D000577:Amides; D010756:Phosphoric Acids