title: [Fine mapping of a pure paroxysmal kinesigenic dyskinesia family].
abstract: OBJECTIVE
  To fine map the gene responsible for pure paroxysmal kinesigenic dyskinesia in a Chinese family.
  
  
  METHODS
  Six additional markers flanking the tightly linked markers were chosen in the candidate region resulting from a whole genome-wide scanning and tested by parameter and nonparameter analysis using Linkage and Genehunter softwares to fine map the candidate region.
  
  
  RESULTS
  Evidence for linkage of the pure paroxysmal kinesigenic dyskinesia to chromosome 3 was further confirmed. A maximum two-lod score of 2.82 at theta=0 was obtained with D3S3669. Critical recombinants place the PKD gene between D3S1314 and D3S1265.
  
  
  CONCLUSIONS
  A new locus of pure paroxysmal kinesigenic dyskinesia (PKD) is localized within a 10.2 cM interval on 3q28-29, between markers D3S1314 and D3S1265.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China.
authors.forename: Ding
authors.initials: D
authors.lastname: Liu
authors.forename: Guo-liang
authors.initials: GL
authors.lastname: Li
authors.forename: Chan-juan
authors.initials: CJ
authors.lastname: Chen
authors.forename: Jin-xia
authors.initials: JX
authors.lastname: Zhou
authors.forename: Bei
authors.initials: B
authors.lastname: Zhang
authors.forename: Zhi-guo
authors.initials: ZG
authors.lastname: Wu
authors.forename: Bo
authors.initials: B
authors.lastname: Xiao
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002819:Chorea / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D015894:Genome, Human / Q000235:genetics; D023281:Genomics; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers