title: Helical-screw directions of diastereoisomeric cyclic alpha-amino acid oligomers.
abstract: Two series of homooligomers composed of diastereoisomeric cyclic alpha-amino acids having two chiral centers at the alpha-carbon and the side chain were synthesized, and their preferred secondary structures were studied in solution and in the crystal state. The oligomers are a new class of helical-foldamers possessing two kinds of chiral centers on the helical backbone and at the lateral surface of the helix.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Masanobu
authors.initials: M
authors.lastname: Nagano
authors.forename: Masakazu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Mitsunobu
authors.initials: M
authors.lastname: Doi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Demizu
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kurihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suemune
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D009842:Oligopeptides