title: [Investigation of dysbiosis developing during "dry" immersion and methods of correction].
abstract: Dysbiotic shifts in intestinal and integumentary microflora were studied in 10 test-subjectes during 7-day "dry" immersion. Essentially every test-subject reduced significantly fecal lactoflora and developed dysbiotic shifts in the microbial landscape of various types of integument. Pharyngeal microflora was analyzed in 22 normal volunteers for 7-day "dry" immersion. Two probiotic preparations were administered to prevent pharyngeal dysbiosis: peroral dry lactobacterin and topical collagen-immobilized lactobacterin. The peroral probiotic stimulated growth of pharyngeal opportunistic pathogens preventing translocations of the intestinal microflora. The topical probiotic, on the opposite, reduced the content of opportunistic pathogens in the throat; however, it provoked gastrointestinal dysbiosis. It appears that the most effective prophylaxis of pharyngeal dysbiosis can be reached by prescription of both topical and peroral probiotics.
authors.forename: V K
authors.initials: VK
authors.lastname: Il'in
authors.forename: A I
authors.initials: AI
authors.lastname: Kriukov
authors.forename: A I
authors.initials: AI
authors.lastname: Volozhin
authors.forename: L P
authors.initials: LP
authors.lastname: Istranov
authors.forename: E V
authors.initials: EV
authors.lastname: Istranova
authors.forename: N V
authors.initials: NV
authors.lastname: Kiriukhina
authors.forename: L V
authors.initials: LV
authors.lastname: Starkova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Morozova
authors.forename: N A
authors.initials: NA
authors.lastname: Usanova
mesh_terms: D000293:Adolescent; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000209:etiology / Q000517:prevention & control*; D001430:Bacteriocins / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007101:Immersion / Q000009:adverse effects*; D007422:Intestines / Q000382:microbiology*; D007778:Lactobacillus / Q000302:isolation & purification; D019936:Probiotics / Q000627:therapeutic use*; D012016:Reference Values; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D001430:Bacteriocins; C008244:lactobacterin