Tunicyclin A, the first plant tricyclic ring cycloheptapeptide from Psammosilene tunicoides.
A novel cycloheptapeptide, tunicyclin A, with a unique tricyclic ring cyclopeptide skeleton, was isolated from Psammosilene tunicoides. Its structure was elucidated by extensive NMR and MS analysis. Biogenetically, tunicyclin A might be derived from cyclo-(Pro(1)-Ser(2)-(gamma-keto-delta-aldehedyl-Glu(3))-Leu(4)-Val(5)-Gly(6)-Ser(7)) via two steps of nucleophilic addition.
Tian
Jun-Mian
JM
Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, P. R. China.
Shen
Yun-Heng
YH
Yang
Xian-Wen
XW
Liang
Shuang
S
Tang
Jian
J
Shan
Lei
L
Zhang
Wei-Dong
WD
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D029748:Caryophyllaceae / Q000737:chemistry*; D004317:Doxorubicin / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D010456:Peptides, Cyclic; C551511:tunicyclin A; D004317:Doxorubicin