Catalytic formal Homo-Nazarov cyclization.
The first catalytic method for the cyclization of vinyl-cyclopropyl ketones (formal homo-Nazarov reaction) is reported. Starting from activated cyclopropanes, heterocyclic, and carbocyclic compounds were obtained under mild conditions using Brønsted acid catalysts. Preliminary investigation of the reaction mechanism indicated a stepwise process.
De Simone
Filippo
F
Laboratory of Catalysis and Organic Synthesis Ecole Polytechnique Fédérale de Lausanne EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.
Andrès
Julien
J
Torosantucci
Riccardo
R
Waser
Jérôme
J
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D014753:Vinyl Compounds / Q000737:chemistry*
D003512:Cyclohexanones; D003521:Cyclopropanes; D007659:Ketones; D014753:Vinyl Compounds