[Qualitative assessment of a noncarcinogenic risk to human health].
The existing methodic approaches to analyzing a noncarcinogenic risk fail to fully solve the tasks set within the basic lines of the activities of the Russian Agency for Consumer Surveillance since there are limited capacities of the quantitative assessment of a noncarcinogenic risk to human health. An algorithm is proposed for basing the indicators assessing a noncarcinogenic risk to human health, which assumes to determine exposure or an exposure marker for a cohort to be examined, to define a response to human health exposure, to construct mathematical "exposure (an exposure marker)-response" models, to determine the ineffective levels exposure for each type of a response, to make the piecewise-linear approximation of a model, and to calculate a slope factor for each linearized interval of an exposure-response model. Application of the proposed methodic approaches makes it possible, provided that the estimation of the cost of risk units, to assess the economic loss risk associated with the pollution of environmental objects, including a preventable risk, and to calculate the indicators of the effectiveness and efficiency of the activities of the bodies and organizations of the Russian Agency for Consumer Surveillance in reducing the risk to the population's health.
Zaĭtseva
N V
NV
Shur
P Z
PZ
Kir'ianov
D A
DA
Alekseev
V B
VB
Sboev
A S
AS
Voiak-Leonovich
O P
OP
D000465:Algorithms; D002391:Catchment Area, Health; D018876:Environmental Illness / Q000453:epidemiology* / Q000517:prevention & control*; D006293:Health Promotion; D006305:Health Status Indicators; D006801:Humans; D008954:Models, Biological; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology