title: Changes in cancer mortality among HIV-infected patients: the Mortalité 2005 Survey.
abstract: BACKGROUND
  The goal of the current study was to describe the distribution and characteristics of malignancy related deaths among human immunodeficiency virus (HIV)-infected patients with use of data obtained from a national survey conducted in France in 2005 and to compare with results obtained from a similar survey conducted in 2000.
  
  
  METHODS
  The underlying cause of death was documented using a standardized questionnaire fulfilled in French hospital wards and networks that were involved in the treatment of HIV-infected patients.
  
  
  RESULTS
  Among the 1042 deaths reported in 2005 (964 were reported in 2000), 344 were cancer related (34%), which represented a significant increase from 2000 (29% of deaths were cancer related) (P=.02); 134 of the cancer-related deaths were AIDS related and 210 were not AIDS related. Among the cancer-related causes of death, the proportion of hepatitis-related cancers (6% in 2000 vs. 11% in 2005) and non-AIDS/hepatitis-related cancers (38% in 2000 vs 50% in 2005) significantly increased from 2000 to 2005 (P=.03 and P=.01, respectively), compared with the proportion of cancer that was AIDS related and adjusting for age and sex. Among cases involving AIDS, the proportion of non-Hodgkin lymphoma-associated deaths did not change statistically significantly between 2000 and 2005 (11% and 10% of deaths, respectively).
  
  
  CONCLUSIONS
  In this study, an increasing proportion of lethal non-AIDS-related cancers was demonstrated from 2000 to 2005; meanwhile, the proportion of lethal AIDS-related cancers remained stable among HIV-infected patients. Thus, cancer prophylaxis, early diagnosis, and improved management should be included in the routine long-term follow-up of HIV-infected patients.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (Inserm), U593, Bordeaux, France. fabrice.bonnet@chu-bordeaux.fr
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bonnet
authors.forename: Christine
authors.initials: C
authors.lastname: Burty
authors.forename: Charlotte
authors.initials: C
authors.lastname: Lewden
authors.forename: Dominique
authors.initials: D
authors.lastname: Costagliola
authors.forename: Thierry
authors.initials: T
authors.lastname: May
authors.forename: Vincent
authors.initials: V
authors.lastname: Bouteloup
authors.forename: Eric
authors.initials: E
authors.lastname: Rosenthal
authors.forename: Eric
authors.initials: E
authors.lastname: Jougla
authors.forename: Patrice
authors.initials: P
authors.lastname: Cacoub
authors.forename: Dominique
authors.initials: D
authors.lastname: Salmon
authors.forename: Geneviève
authors.initials: G
authors.lastname: Chêne
authors.forename: Philippe
authors.initials: P
authors.lastname: Morlat
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality*