title: Taste-aversion conditioning, but not immunosuppression conditioning, occurs under partial water deprivation.
abstract: The authors investigated whether conditioned taste aversion and immunosuppression took place when water was available during conditioning and test protocols. The authors elicited taste-aversion conditioning and immunosuppression in outbred CD1-strain mice by pairing a conditioned stimulus (sucrose or saccharin solution) with an unconditioned stimulus (cyclophosphamide) that causes gastrointestinal upset and is immunosuppressive. The authors introduced a new conditioning protocol: 5 pairings of a saccharin solution with a low-dose injection of cyclophosphamide. Under these conditions, the authors generated conditioned aversion to saccharin but did not generate conditioned decrease of the antibody response. The authors conclude that taste-aversion conditioning, but not immunosuppression conditioning, occurred under partial water deprivation.
authors.affiliation: Universitat de Barcelona, Facultat de Psicologia, Departament de Personalitat, Passeig de la Vall d'Hebron, 171, 08035 Barcelona, Spain. jvidal@ub.edu
authors.forename: José
authors.initials: J
authors.lastname: Vidal
authors.forename: Victoria D
authors.initials: VD
authors.lastname: Chamizo
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology; D003214:Conditioning, Classical / Q000502:physiology*; D003520:Cyclophosphamide / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D007075:Immunoglobulin M / Q000097:blood; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D012439:Saccharin; D013395:Sucrose; D013649:Taste / Q000276:immunology*; D014868:Water Deprivation / Q000502:physiology*
chemical_list: D007075:Immunoglobulin M; D013395:Sucrose; D003520:Cyclophosphamide; D006433:Hemocyanins; D012439:Saccharin; C032808:keyhole-limpet hemocyanin