title: The hypothesis of overwork weakness in Charcot-Marie-Tooth: a critical evaluation.
abstract: OBJECTIVE
  It has been reported that the non-dominant hand of patients with Charcot-Marie-Tooth disease is stronger than the dominant hand as a result of overwork weakness. The objective of this study was to determine if this hypothesis could be verified in our population.
  
  
  METHODS
  Survey.
  
  
  METHODS
  Twenty-eight patients with Charcot-Marie-Tooth disease type I or II from a rehabilitation department of a university hospital in the Netherlands.
  
  
  METHODS
  The strength of 3 intrinsic muscle groups of the dominant and non-dominant hand were determined using the Medical Research Council scale and the Rotterdam Intrinsic Hand Myometer. Furthermore, grip strength, pinch and key grip strength were measured.
  
  
  RESULTS
  We found no differences in muscle strength for the dominant and non-dominant hand, except for a stronger key grip strength of the dominant hand in patients with Charcot-Marie-Tooth disease type II.
  
  
  CONCLUSIONS
  In our population, the dominant hand of patients with Charcot-Marie-Tooth disease type I and II was equally strong as the non-dominant hand, suggesting that there is no presence of overwork weakness in the dominant hand in our group of patients. This implies that patients with Charcot-Marie-Tooth disease do not have to limit the use of their hands in daily life in order to prevent muscle strength loss.
authors.affiliation: Department of Rehabilitation, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands. m.vanpomeren@sophiarevalidatie.nl
authors.forename: Madlenka
authors.initials: M
authors.lastname: van Pomeren
authors.forename: Ruud W
authors.initials: RW
authors.lastname: Selles
authors.forename: Berbke T J
authors.initials: BT
authors.lastname: van Ginneken
authors.forename: Ton A R
authors.initials: TA
authors.lastname: Schreuders
authors.forename: Wim G M
authors.initials: WG
authors.lastname: Janssen
authors.forename: Henk J
authors.initials: HJ
authors.lastname: Stam
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002607:Charcot-Marie-Tooth Disease / Q000503:physiopathology* / Q000534:rehabilitation; D018737:Hand Strength / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D018908:Muscle Weakness / Q000503:physiopathology*; D052581:Pinch Strength / Q000502:physiology; D055815:Young Adult