title: [Pharmacotherapy of smoking cessation with application of nicotine and nicotine free drugs].
abstract: The article summarise the current knowledge about medicaments used in smoking cessation. In detail are discussed drugs, which are the first choice in treatment of nicotine dependence. The basic preparations of Nicotine Replacement Therapy (NRT) are: chewing gum with nicotine which allowed for instantaneous reaction on craving for nicotine, and nicotine patches which supplement organism with this alkaloid with constant rate. The efficacy of other NRT preparations (vapour inhaler, nasal spray, sublingual tablet, lozenge) are on the some level as nicotine chewing gums and nicotine patches. Alternatives for NRT are two drugs bupropion and varenicline. Both drugs are effective in treatment the nicotine dependence and as well as nicotine containing medicaments can be us as a first line drugs. The efficacy of other drugs (nortryptyline, mecalamine, clonidine) have not been proved in randomized controlled studies.
authors.affiliation: Laboratorium Badań Srodowiskowych, Katedra i Zakład Toksykologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu. eflorek@ump.edu.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Florek
authors.forename: Wojciech
authors.initials: W
authors.lastname: Piekoszewski
mesh_terms: D001552:Benzazepines / Q000627:therapeutic use; D016642:Bupropion / Q000627:therapeutic use; D006801:Humans; D009538:Nicotine / Q000008:administration & dosage*; D011810:Quinoxalines / Q000627:therapeutic use; D011978:Receptors, Nicotinic / Q000187:drug effects; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000379:methods*; D014029:Tobacco Use Disorder / Q000188:drug therapy*; D000068580:Varenicline
chemical_list: D001552:Benzazepines; D011810:Quinoxalines; D011978:Receptors, Nicotinic; D016642:Bupropion; D009538:Nicotine; D000068580:Varenicline