title: [Real-time contrast-enhanced ultrasound in the evaluation of focal liver lesions: diagnostic efficacy and economical issues from a French multicentric study].
abstract: The recent introduction of high-end ultrasound equipment combined with recent contrast agents provides marked improvements in the characterization of focal liver lesions as previously reported by monocentric studies. The aim of the present study was to evaluate the diagnostic performance of Contrast-Enhanced Ultrasonography (CEUS) using SonoVue as well as its medico-economic value for characterization of focal liver lesions. These nodules were not characterized on previous CT or conventional sonography. This prospective multicentric study conducted in 15 French centres found diagnostic performances similar to those reported for CT and MRI, with a concordance rate of 84.5%, sensitivity greater than 80% and specificity greater than 90% for all types of lesions. Higher acceptance was found for CEUS compared to other imaging modalities. Economical assessment based on examination reimbursment and contrast agent cost showed a lower cost for contrast ultrasound versus CT and MRI. This French multicentric study confirmed the high diagnostic value of CEUS for focal liver lesion characterization and demonstrated a lower economical impact compared to other imaging modalities such as CT and MRI.
authors.affiliation: Pole Imagerie, CIC-IT Ultrasons-Radiopharmaceutiques, Hôpital Bretonneau, CHRU de Tours, UMR Inserm 930-CNRS 2448-Université François Rabelais, 37044 Tours Cedex 9, France. tranquart@med.univ-tours.fr
authors.forename: F
authors.initials: F
authors.lastname: Tranquart
authors.forename: J M
authors.initials: JM
authors.lastname: Correas
authors.forename: V
authors.initials: V
authors.lastname: Ladam Marcus
authors.forename: P
authors.initials: P
authors.lastname: Manzoni
authors.forename: V
authors.initials: V
authors.lastname: Vilgrain
authors.forename: C
authors.initials: C
authors.lastname: Aube
authors.forename: A
authors.initials: A
authors.lastname: Elmaleh
authors.forename: L
authors.initials: L
authors.lastname: Chami
authors.forename: M
authors.initials: M
authors.lastname: Claudon
authors.forename: M
authors.initials: M
authors.lastname: Cuilleron
authors.forename: B
authors.initials: B
authors.lastname: Diris
authors.forename: F
authors.initials: F
authors.lastname: Garibaldi
authors.forename: O
authors.initials: O
authors.lastname: Lucidarme
authors.forename: D
authors.initials: D
authors.lastname: Marion
authors.forename: C
authors.initials: C
authors.lastname: Beziat
authors.forename: A
authors.initials: A
authors.lastname: Rode
authors.forename: J P
authors.initials: JP
authors.lastname: Tasu
authors.forename: H
authors.initials: H
authors.lastname: Trillaud
authors.forename: A
authors.initials: A
authors.lastname: Bleuzen
authors.forename: A
authors.initials: A
authors.lastname: Le Gouge
authors.forename: B
authors.initials: B
authors.lastname: Giraudeau
authors.forename: E
authors.initials: E
authors.lastname: Rusch
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000000981:diagnostic imaging*; D016001:Confidence Intervals; D003287:Contrast Media; D003627:Data Interpretation, Statistical; D003937:Diagnosis, Differential; D020518:Focal Nodular Hyperplasia / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005602:France; D006391:Hemangioma / Q000000981:diagnostic imaging*; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology / Q000556:secondary; D008279:Magnetic Resonance Imaging / Q000191:economics / Q000379:methods; D018579:Patient Selection; D010743:Phospholipids; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D014057:Tomography, X-Ray Computed / Q000191:economics / Q000379:methods; D014463:Ultrasonography / Q000191:economics / Q000379:methods*
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride