Topical application of Garcinia mangostana L. pericarp gel as an adjunct to periodontal treatment.
OBJECTIVE
To evaluate the effects of gel containing Garcinia mangostana L. pericarp extract (GM gel) applied topically as an adjunct to periodontal treatment.


METHODS
Subjects who had periodontal pockets on their single-rooted teeth were randomized into the test or control group. Subjects in the test group received periodontal treatment consisting of scaling, root planing and subgingival application of GM gel while those in the control group received scaling and root planing without GM gel application.


METHODS
Mahidol University, Faculty of Dentistry, Thailand.


METHODS
Clinical parameters included probing pocket depth (PPD), clinical attachment level (CAL), bleeding on probing (BOP), Gingival Index (GI) and Plaque Index (PI). Microbiological parameter included subgingival microbial composition as examined by phase contrast microscopy.


RESULTS
Clinical improvement compared to baseline was found in both groups (P < 0.05). The test group exhibited significantly higher reduction in mean PPD, GI and BOP than the control group at the 3rd month after treatment (P < 0.05). Subgingival microbial composition changed from diseased state to that compatible with health after treatment in both groups. However, significant differences between groups were found only in the mean percentage of cocci at the 1st and 3rd month after treatment (P < 0.05).


CONCLUSIONS
GM gel could enhance the clinical effects of periodontal treatment.
Rassameemasmaung
Supanee
S
Department of Oral Medicine, Faculty of Dentistry, Mahidol University, Ratchathewi, Bangkok 10400, Thailand. dtsrs@mahidol.ac.th
Sirikulsathean
Anongporn
A
Amornchat
Cholticha
C
Maungmingsook
Pawinee
P
Rojanapanthu
Pleumchitt
P
Gritsanaphan
Wandee
W
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant / Q000379:methods; D005260:Female; D029762:Garcinia mangostana; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D010512:Periodontal Index; D008517:Phytotherapy; D028321:Plant Preparations / Q000627:therapeutic use*
D005782:Gels; D028321:Plant Preparations