title: Treatment of basal cell carcinomas in patients with nevoid basal cell carcinoma syndrome.
abstract: BACKGROUND
  Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by the development of multiple basal cell carcinomas (BCCs). A major problem for these patients is the enormous amount of BCCs which can invade in the deep underlying structures, especially in the face. Different treatment modalities are used in these patients; surgical excision, Mohs micrographic surgery, cryotherapy, photodynamic therapy, ablative laser therapy and topical 5% imiquimod. There is no evidence based advice how to treat a NBCCS patient.
  
  
  OBJECTIVE
  To give a review of the literature about the possible treatment modalities for the multiple BCCs in NBCCS patients.
  
  
  RESULTS
  Literature consists mainly of case reports; no evidence based advice how to treat a NBCCS patient exists. Multiple treatments are available (surgical and non-surgical), and a lot of them can be combined. Treatment in a megasession is an option to diminish the medical and social inconvenience for the patient.
authors.affiliation: Department of Dermatology, Erasmus MC Rotterdam, Rotterdam, The Netherlands. s.vandergeer@erasmusmc.nl
authors.forename: S
authors.initials: S
authors.lastname: van der Geer
authors.forename: J U
authors.initials: JU
authors.lastname: Ostertag
authors.forename: G A M
authors.initials: GA
authors.lastname: Krekels
mesh_terms: D000634:Aminoquinolines / Q000627:therapeutic use; D001478:Basal Cell Nevus Syndrome / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D000077271:Imiquimod; D053685:Laser Therapy; D010778:Photochemotherapy; D012878:Skin Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*
chemical_list: D000634:Aminoquinolines; D000077271:Imiquimod