title: [Anticytokine therapy in sepsis and why it fails].
abstract: Anticytokine therapy in sepsis belongs to a subgroup of therapeutic interventions referred to as antiinflammatory or immunomodulatory strategies in the intensive care literature. Between the mid-1980s and the late 1990s, this approach was considered very promising. Against all expectations, it proved ineffective or even harmful in many cases. However, the recent literature is suggestive of a renewed interest in the topic. Therefore, we attempted at a retrospective search for causes of the failure.
authors.affiliation: Dept. of Anaesthesiology and Resuscitation, University Hospital Ostrava, Czech Republic. Vaclav.Chylek@seznam.cz
authors.forename: Václav
authors.initials: V
authors.lastname: Chýlek
authors.forename: Roman
authors.initials: R
authors.lastname: Kula
authors.forename: Michal
authors.initials: M
authors.lastname: Holub
authors.forename: Pavel
authors.initials: P
authors.lastname: Szturz
authors.forename: Peter
authors.initials: P
authors.lastname: Sklienka
authors.forename: Jan
authors.initials: J
authors.lastname: Máca
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology* / Q000502:physiology; D006801:Humans; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology
chemical_list: D000911:Antibodies, Monoclonal; D016207:Cytokines