Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937.
Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.
Hohmann
Claudia
C
Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
Schneider
Kathrin
K
Bruntner
Christina
C
Irran
Elisabeth
E
Nicholson
Graeme
G
Bull
Alan T
AT
Jones
Amanda L
AL
Brown
Roselyn
R
Stach
James E M
JE
Goodfellow
Michael
M
Beil
Winfried
W
Krämer
Marco
M
Imhoff
Johannes F
JF
Süssmuth
Roderich D
RD
Fiedler
Hans-Peter
HP
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001583:Benzoxazoles / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D012623:Seawater / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*; D014871:Water Microbiology
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001583:Benzoxazoles; C544384:caboxamycin