title: Causes of death in HIV-infected persons who have tuberculosis, Thailand.
abstract: Up to 50% of persons with HIV and a diagnosis of tuberculosis (TB) in Thailand die during TB treatment. In a prospective observational study, a team of physicians ascribed the cause of death after reviewing verbal autopsies (interviews of family members about events preceding death), laboratory data, and medical records. Of 849 HIV-infected TB patients enrolled, 142 (17%) died. The cause of death was TB for 38 (27%), including 6 with multidrug-resistant TB and 20 with disseminated TB; an HIV-associated condition other than TB for 50 (35%); and a condition unrelated to TB or HIV for 22 (15%). Twenty-three patients (16%) were judged not to have had TB at all. Death from all causes except those unrelated to TB or HIV was less common in persons receiving antiretroviral therapy (ART). In addition to increasing the use of ART, death rates may be reduced through expanded use of modern TB diagnostic techniques.
authors.affiliation: Centers for Disease Control and Prevention, Atlanta, Georgia, USA. kcain@cdc.gov
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Cain
authors.forename: Thanomsak
authors.initials: T
authors.lastname: Anekthananon
authors.forename: Channawong
authors.initials: C
authors.lastname: Burapat
authors.forename: Somsak
authors.initials: S
authors.lastname: Akksilp
authors.forename: Wiroj
authors.initials: W
authors.lastname: Mankhatitham
authors.forename: Chawin
authors.initials: C
authors.lastname: Srinak
authors.forename: Sriprapa
authors.initials: S
authors.lastname: Nateniyom
authors.forename: Wanchai
authors.initials: W
authors.lastname: Sattayawuthipong
authors.forename: Theerawit
authors.initials: T
authors.lastname: Tasaneeyapan
authors.forename: Jay K
authors.initials: JK
authors.lastname: Varma
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D002423:Cause of Death; D015658:HIV Infections / Q000150:complications* / Q000401:mortality; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D013785:Thailand / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000401:mortality; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents