title: HCV treatment with pegylated interferon and ribavirin in patients with haemophilia and HIV/HCV co-infection.
abstract: Individuals with haemophilia are frequently infected with both human immunodeficiency virus (HIV) and hepatitis C virus (HCV); however, limited evidence is currently available regarding the efficacy of HCV treatment with pegylated interferon and ribavirin in this patient population. The aim of this study was to review HCV treatment outcomes in a cohort of patients with haemophilia and HIV/HCV co-infection. A retrospective, single centre review of 13 consecutive patients treated with pegylated interferon and ribavirin was performed. All patients were male with haemophilia A and a median age of 43 (range 27-62) at initiation of HCV therapy. Nine of 13 (69%) patients had genotype (gt1) 1 HCV (3 x gt3, 1 x gt4). Twelve of 13 (92%) were receiving ART, with a mean CD4+ count of 428 cells microL(-1) (range 175-928 cells microL(-1)) at initiation of HCV therapy. Six of 11 (55%) patients achieved EVR (3 x gt1, 2 x gt3, 1 x gt4) at 12 weeks, 4/13 (31%) had EOTR (2 x gt1, 2 x gt3) and 1/13 (8%) achieved sustained virological response (1 x gt1). Seven of 11 (64%) patients normalized ALT during therapy wherein mean ALT fell from 101 to 76 U L(-1). Only 1/13 (8%) patients discontinued therapy prematurely due to side effects. CD4+ cell counts and HIV viral load remained stable during HCV treatment, with a mean 437 cells microL(-1) and <50 copies mL(-1) at 48 weeks respectively. Patients in our cohort with haemophilia and HCV/HIV co-infection responded poorly to HCV treatment. Alternative HCV treatment strategies need to be considered in patients with haemophilia and HIV/HCV co-infection.
authors.affiliation: Infectious Diseases Unit, The Alfred Hospital, Melbourne, FL, Australia. j.denholm@alfred.org.au
authors.forename: J T
authors.initials: JT
authors.lastname: Denholm
authors.forename: E J
authors.initials: EJ
authors.lastname: Wright
authors.forename: A
authors.initials: A
authors.lastname: Street
authors.forename: J J
authors.initials: JJ
authors.lastname: Sasadeusz
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D000328:Adult; D001315:Australia; D005838:Genotype; D015497:HIV-1 / Q000276:immunology*; D006467:Hemophilia A / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012254:Ribavirin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D012254:Ribavirin; D007372:Interferons