Papillary dermal elastosis: a unique elastic tissue disorder or an unusual manifestation of pseudoxanthoma elasticum-like papillary dermal elastolysis?
There are numerous acquired elastic tissue disorders, several of which present cutaneously with small yellow-to-white papules resembling plucked chicken skin. Differential diagnoses depend on the abnormalities within the network of elastic tissues. We report a case with distinct histologic features, which may represent a unique elastic tissue disorder or a variant of pseudoxanthoma elasticum-like papillary dermal elastolysis. Our patient's clinical presentation includes scattered 1-2 mm white-to-yellow papules without surface change on the upper back and neck region. Histology is characterized by foci of clumped, granular elastic tissue, which have replaced the oxytalan and elaunin fibers, alternating with foci of decreased concentrations of normal-appearing elastic fibers within the papillary dermis. Given its characteristics, we have termed this novel entity 'papillary dermal elastosis'.
Wang
Annie R
AR
Department of Dermatology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
Lewis
Kevan
K
Lewis
Michelle
M
Robinson-Bostom
Leslie
L
D000328:Adult; D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D011561:Pseudoxanthoma Elasticum / Q000188:drug therapy / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D014212:Tretinoin / Q000627:therapeutic use
D007641:Keratolytic Agents; D014212:Tretinoin