title: Genome-based approaches to develop vaccines against bacterial pathogens.
abstract: Bacterial infectious diseases remain the single most important threat to health worldwide. Although conventional vaccinology approaches were successful in conferring protection against several diseases, they failed to provide efficacious solutions against many others. The advent of whole-genome sequencing changed the way to think about vaccine development, enabling the targeting of possible vaccine candidates starting from the genomic information of a single bacterial isolate, with a process named reverse vaccinology. As the genomic era progressed, reverse vaccinology has evolved with a pan-genome approach and multi-strain genome analysis became fundamental for the design of universal vaccines. This review describes the applications of genome-based approaches in the development of new vaccines against bacterial pathogens.
authors.affiliation: Novartis Vaccines and Diagnostics, Via Fiorentina 1, 53100 Siena, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Serruto
authors.forename: Laura
authors.initials: L
authors.lastname: Serino
authors.forename: Vega
authors.initials: V
authors.lastname: Masignani
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Pizza
mesh_terms: D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology*; D015195:Drug Design; D010861:Fimbriae, Bacterial / Q000276:immunology; D016680:Genome, Bacterial; D022401:Meningococcal Vaccines / Q000276:immunology; D038541:Neisseria meningitidis, Serogroup B / Q000276:immunology; D022242:Pneumococcal Vaccines / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology
chemical_list: D001428:Bacterial Vaccines; D022401:Meningococcal Vaccines; D022242:Pneumococcal Vaccines