title: Carotid intima-media thickness and distensibility measured by MRI at 3 T versus high-resolution ultrasound.
abstract: We evaluated an MRI protocol at 3 T for the assessment of morphological and functional properties of the common carotid artery (CCA) in 32 healthy volunteers and 20 patients with high-grade internal carotid artery stenosis. Wall thickness of the CCA was measured by using multislice 2D T2 dark blood fast spin echo sequences and compared with intima-media thickness (IMT) determined by ultrasound. Carotid distensibility coefficient (DC) quantified by blood pressure and CCA diameter change during the cardiac cycle was measured by ECG gated 3D T1 CINE MRI and M-mode ultrasound. Apart from generally higher values in MRI high agreement was found for wall thickness and compliance in volunteers and patients. Remaining differences between both methods may be attributed to slightly different methods for measuring IMT and DC. Our findings indicate that MRI at 3 T is a feasible and promising tool for the comprehensive assessment of normal carotid geometry and function.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, University of Freiburg, Freiburg, Germany. andreas.harloff@uniklinik-freiburg.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Harloff
authors.forename: Timo
authors.initials: T
authors.lastname: Zech
authors.forename: Alex
authors.initials: A
authors.lastname: Frydrychowicz
authors.forename: Martin
authors.initials: M
authors.lastname: Schumacher
authors.forename: Joachim
authors.initials: J
authors.lastname: Schöllhorn
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hennig
authors.forename: Cornelius
authors.initials: C
authors.lastname: Weiller
authors.forename: Michael
authors.initials: M
authors.lastname: Markl
mesh_terms: D000368:Aged; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging* / Q000473:pathology*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D005260:Female; D049690:History, Ancient; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017539:Tunica Intima / Q000000981:diagnostic imaging / Q000473:pathology; D017540:Tunica Media / Q000000981:diagnostic imaging / Q000473:pathology; D014463:Ultrasonography / Q000379:methods*