Two cases of pollen-food allergy syndrome to soy milk diagnosed by skin prick test, specific serum immunoglobulin E and microarray analysis.
Oral allergy syndrome to soy milk is classified as a phenotype of pollen-food allergy syndrome (PFAS). As causative antigens, Gly m 4 (Bet v 1 homolog, 17 kD) and oleosin (23 kD), have been reported. In this study, we report two cases of PFAS to soy milk. Both cases showed positive reactions to soy milk in skin prick tests (SPT) and to Gly m 4 in specific serum immunoglobulin (Ig)E antibody. When we measured specific serum IgE antibody of soy-related proteins using a new laboratory testing method, microarray analysis, both cases showed a positive reaction for Bet v 1. One case was weakly positive for a soybean protein, beta-conglycinin. Other results for reactivity to soy, peanut, cross-reactive carbohydrate determinants and profilin were negative. Based on these results, we diagnosed the two cases as PFAS to Gly m 4. We also performed protein microarray analysis and found it useful as a screening test for immediate allergy, such as PFAS.
Yagami
Akiko
A
Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan. ayagami@nch.go.jp
Inaba
Yasuko
Y
Kuno
Yuki
Y
Suzuki
Kayoko
K
Tanaka
Akira
A
Sjolander
Sigrid
S
Saito
Hirohisa
H
Matsunaga
Kayoko
K
D000328:Adult; D052179:Antigens, Plant / Q000009:adverse effects / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008565:Membrane Proteins / Q000009:adverse effects / Q000276:immunology; D008875:Middle Aged; D010940:Plant Proteins / Q000009:adverse effects / Q000276:immunology; D040081:Protein Array Analysis; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications* / Q000276:immunology; D012882:Skin Tests; D041942:Soy Milk; D013025:Glycine max / Q000009:adverse effects / Q000276:immunology; D013577:Syndrome
D052179:Antigens, Plant; C530536:Gly m 4 allergen, Glycine max; D008565:Membrane Proteins; D010940:Plant Proteins; C079299:oleosin 24 protein, Glycine max; D007073:Immunoglobulin E