title: Computer-enhanced high-throughput genetic screens of C. elegans in a microfluidic system.
abstract: Most visual screens based on fluorescent markers are currently limited in throughput and accuracy. Here we present the first genetic screen of a mutagenized population of C. elegans in a microfluidic device. Animal handling streamlined by a microfluidic device and intuitive control software enabled the identification of novel mutants and a large screening speed.
authors.affiliation: Interdisciplinary Program in Bioengineering, Georgia Institute of Technology, Atlanta, GA, USA.
authors.forename: Matthew M
authors.initials: MM
authors.lastname: Crane
authors.forename: Kwanghun
authors.initials: K
authors.lastname: Chung
authors.forename: Hang
authors.initials: H
authors.lastname: Lu
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D003201:Computers; D044085:Microfluidics; D012984:Software