title: Reinnervation cannot be interpreted as an indicator of electrophysiologic improvement in amyothrophic lateral sclerosis.
abstract: Denervation and reinnervation comprise a dynamic process that begins in the early periods of amyothrophic lateral sclerosis and lasts until the final individual motor neuron dies. A dynamic process like denervation-reinnervation that is found in the natural course of the disease can not be presented as a neurophysiologic measure. Other parameters, such as motor unit number estimation, compound muscle action potential amplitude and neurophysiologic index, seem more appropriate for therapeutic trials.
authors.forename: Semai
authors.initials: S
authors.lastname: Bek
authors.forename: Tayfun
authors.initials: T
authors.lastname: Kasikci
authors.forename: Zeki
authors.initials: Z
authors.lastname: Odabasi
mesh_terms: D000200:Action Potentials / Q000502:physiology; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology / Q000628:therapy*; D015415:Biomarkers; D004576:Electromyography / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008168:Lung / Q000294:innervation; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation; D011999:Recruitment, Neurophysiological / Q000502:physiology; D012129:Respiratory Function Tests / Q000379:methods; D013223:Statistics as Topic; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers