title: Efficient, regioselective palladium-catalyzed tandem Heck-isomerization reaction of aryl bromides and non-allylic benzyl alcohols.
abstract: An efficient and mild method to couple aryl bromides and activated non-allylic alcohols in a Heck reaction with tandem isomerization to selectively afford high yields of 1,5-diarylalkan-1-ones has been developed. Mechanistic insight was gained through NMR studies of products derived from deuterium-labeled intermediates.
authors.affiliation: Discovery Medicinal Chemistry, Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA. crawlem@wyeth.com
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Crawley
authors.forename: Kristin M
authors.initials: KM
authors.lastname: Phipps
authors.forename: Igor
authors.initials: I
authors.lastname: Goljer
authors.forename: John F
authors.initials: JF
authors.lastname: Mehlmann
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Lundquist
authors.forename: John W
authors.initials: JW
authors.lastname: Ullrich
authors.forename: Cuijian
authors.initials: C
authors.lastname: Yang
authors.forename: Paige E
authors.initials: PE
authors.lastname: Mahaney
mesh_terms: D001592:Benzyl Alcohols / Q000737:chemistry*; D001965:Bromides / Q000737:chemistry*; D002384:Catalysis; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001592:Benzyl Alcohols; D001965:Bromides; D010165:Palladium