title: An immunohistochemical study of feline endometrial adenocarcinoma.
abstract: Feline endometrial adenocarcinomas are uncommon malignant neoplasms that have to date been poorly characterized. The present immunohistochemical study describes the expression of the pancytokeratins AE1 and AE3, cytokeratin-14, vimentin, alpha-actin, cyclo-oxygenase-2, E-cadherin, beta-catenin, the progesterone receptor, the oestrogen receptor and caveolin-1 within normal feline uterine tissue and tissue from six cats with endometrial adenocarcinoma. Synthesis of cyclo-oxygenase-2 and reduced expression of progesterone receptors may be involved in the neoplastic transformation of feline endometrium. The loss of cellular adhesion that occurs within these tumours does not require down-regulation of E-cadherin expression and nuclear translocation of beta-catenin is not a feature of these neoplasms.
authors.affiliation: Instituto de Ciências Biomédicas Abel Salazar - Universidade do Porto (ICBAS-UP), Pathology and Molecular Immunology, Largo Prof. Abel Salazar 2, 4099-003 Porto, Portugal.
authors.forename: R M
authors.initials: RM
authors.lastname: Gil da Costa
authors.forename: M
authors.initials: M
authors.lastname: Santos
authors.forename: I
authors.initials: I
authors.lastname: Amorim
authors.forename: C
authors.initials: C
authors.lastname: Lopes
authors.forename: P Dias
authors.initials: PD
authors.lastname: Pereira
authors.forename: A M
authors.initials: AM
authors.lastname: Faustino
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D016022:Case-Control Studies; D002371:Cat Diseases / Q000378:metabolism*; D002415:Cats; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000662:veterinary*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor