title: [Excavated pulmonary opacity in diabetes].
abstract: Mucormycosis or zygomycosis is a group of infections caused by filamentous fungi of the mucorales order belonging to the zygomycetes family. They generally appear in patients with uncontrolled diabetes or immunodepression, especially neutropenic immunodepression. Incidence has increased with progress in immunosuppressive therapy and chemotherapy and the absence of the use of antifungal prophylactic agents effective against mucors. We report the case of a diabetic patient presenting with an excavated opacity in the right lung which failed to improve after receiving non-specific antibiotic treatment. Direct examination of the bronchial washing specimen led to the diagnosis of pulmonary mucormycosis. Prognosis depends mainly on early diagnosis, enabling appropriate treatment with amphotericin B. Mortality remains high, around 80%; diagnosis is commonly established post-mortem.
authors.affiliation: Service de pneumo-allergologie, CHU Hédi-Chaker, 3029 Sfax, Tunisie.
authors.forename: S
authors.initials: S
authors.lastname: Fouzi
authors.forename: H
authors.initials: H
authors.lastname: Ayadi
authors.forename: A
authors.initials: A
authors.lastname: Sellami
authors.forename: W K
authors.initials: WK
authors.lastname: Rekik
authors.forename: N
authors.initials: N
authors.lastname: Guermazi
authors.forename: A
authors.initials: A
authors.lastname: Ayadi
authors.forename: A
authors.initials: A
authors.lastname: Ayoub
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001980:Bronchi / Q000382:microbiology; D001999:Bronchoscopy; D048909:Diabetes Complications / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D008168:Lung / Q000473:pathology*; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D008297:Male; D009091:Mucormycosis / Q000150:complications* / Q000382:microbiology / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents