title: Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats.
abstract: Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. beta-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations.
authors.affiliation: Laboratory of Evaluation of Psychobioactive Drugs and its Toxicology, Federal University of Pernambuco, 50670-901 Recife PE, Brazil. Edvaldo.ra@gmail.com
authors.forename: Edvaldo Rodrigues
authors.initials: ER
authors.lastname: de Almeida
authors.forename: Flávia Raquel Santos
authors.initials: FR
authors.lastname: Lucena
authors.forename: Camilla Vila Nova Soares
authors.initials: CV
authors.lastname: Silva
authors.forename: Wilson
authors.initials: W
authors.lastname: da Silva Costa-Junior
authors.forename: Jouse Bezerra
authors.initials: JB
authors.lastname: Cavalcanti
authors.forename: Gerald Bosco Lindoso
authors.initials: GB
authors.lastname: Couto
authors.forename: Luiz Lúcio Soares
authors.initials: LL
authors.lastname: da Silva
authors.forename: Diógenes Luís
authors.initials: DL
authors.lastname: da Mota
authors.forename: Alex Benício
authors.initials: AB
authors.lastname: da Silveira
authors.forename: Samuel Daniel
authors.initials: SD
authors.lastname: de Sousa Filho
authors.forename: Aldo Cezar Passilongo
authors.initials: AC
authors.lastname: da Silva
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D005260:Female; D007962:Leukocytes / Q000473:pathology; D008297:Male; D009285:Naphthoquinones / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000473:pathology; D013723:Teratogens / Q000633:toxicity*; D036401:Toxicity Tests, Chronic; D000637:Transaminases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D009285:Naphthoquinones; D013723:Teratogens; C014638:beta-lapachone; D005723:gamma-Glutamyltransferase; D000637:Transaminases; D000469:Alkaline Phosphatase