title: Thermosensitive PEG-PCL-PEG hydrogel controlled drug delivery system: sol-gel-sol transition and in vitro drug release study.
abstract: In this article, biodegradable and low molecular weight poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) triblock copolymers were successfully synthesized. Aqueous solution of the obtained PECE copolymers underwent sol-gel-sol transition as temperature increased which was flowing sol at room temperature and then turned into nonflowing gel at body temperature. Sol-gel-sol phase transition behaviors of aqueous PECE solutions were studied using rheometry and test tube-inverting method, which were affected by many factors, including the heating/cooling procedure and different additives in copolymers aqueous solution. In vitro drug release behavior was studied using bovine serum albumin (BSA) and Vitamin B(12) (VB(12)) as model drugs, and the PECE hydrogel could protect BSA from acidic degradation for 1 week at least. Therefore, PECE hydrogel is believed to be promising for injectable in situ gel-forming controlled drug delivery system due to their great thermosensitivity and biodegradability.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, and School of Life Science, Sichuan University, Chengdu 610041, China.
authors.forename: Chang Yang
authors.initials: CY
authors.lastname: Gong
authors.forename: Peng Wei
authors.initials: PW
authors.lastname: Dong
authors.forename: Shuai
authors.initials: S
authors.lastname: Shi
authors.forename: Shao Zhi
authors.initials: SZ
authors.lastname: Fu
authors.forename: Jin Liang
authors.initials: JL
authors.lastname: Yang
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: Yu Quan
authors.initials: YQ
authors.lastname: Wei
authors.forename: Zhi Yong
authors.initials: ZY
authors.lastname: Qian
mesh_terms: D000143:Acids / Q000737:chemistry; D002850:Chromatography, Gel; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012212:Rheology; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000737:chemistry
chemical_list: D000143:Acids; D003692:Delayed-Action Preparations; D020100:Hydrogels; D011091:Polyesters; C502908:poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol); D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D014805:Vitamin B 12