The effects of treatment for posterior fossa brain tumors on selective attention.
We sought to identify whether deficits in selective attention are present in pediatric brain tumor patients. Selective attention was assessed with covert-orienting, filtering, and visual-search tasks in 54 patients with either (1) posterior fossa (PF) tumors treated with cranial radiation and surgery (n = 22); (2) PF tumors treated with surgery alone (n = 17); or (3) non-CNS tumors (n = 15), who served as a patient control group. To account for normal development, patient performance was also compared with that of healthy age-matched controls (n = 10). We found that in PF tumor patients selective attention was impaired, regardless of whether they were treated with cranial radiation and surgery or surgery alone. However, patients treated with cranial radiation were most impaired. These patients may have greater damage to posterior brain regions know to mediate selective attention as the result of tumor location, effects of surgery, and higher doses of radiation to the posterior regions of the brain. These findings help to elucidate the potential impact of pediatric brain tumors and their treatment on discrete attentional skills.
Mabbott
Donald J
DJ
Department of Psychology, Hospital for Sick Children/University of Toronto, Ontario, Canada. donald.mabbott@sickkiids.ca
Snyder
Janice J
JJ
Penkman
Louise
L
Witol
Adrienne
A
D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D001932:Brain Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy* / Q000601:surgery*; D002648:Child; D030141:Feedback, Psychological; D005260:Female; D006801:Humans; D015192:Infratentorial Neoplasms / Q000503:physiopathology* / Q000532:radiotherapy / Q000601:surgery; D007360:Intelligence; D007361:Intelligence Tests; D008297:Male; D009483:Neuropsychological Tests; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology