title: Vascular reactivity in the experimental, simvastatin-treated diabetes with endothelial dysfunction.
abstract: BACKGROUND
  The aim of this study was to evaluate the effect of simvastatin therapy on general characteristics of diabetes and vascular reactivity in the 14 week-old streptozotosin-diabetic rats.
  
  
  METHODS
  Twenty-four Sprague-Dawley male rats were divided into four groups as following: control, control-statin, diabetes and diabetes-statin.
  
  
  RESULTS
  We observed that hyperglycemia and weight-loss observed in diabetic rats were partially treated with simvastatin, but were still different from the control group. After thapsigargin, the endothel-mediated acetylcholine releasing responses were decreased; the releasing response in diabetes-statin group differed from the diabetic group.
  
  
  CONCLUSIONS
  Simvastatin treatment in diabetic rats, in addition to the treatment of diabetic dislipidemia, has also partially treated the endothel-mediated releasing response in diabetes. We observed that thapsigargin reduces the response of the aortic rings to the current substance (Fig. 5, Ref. 15).
authors.affiliation: Ankara Atatürk Teaching and Research Hospital, Department of General Surgery, Ankara, Turkey.
authors.forename: Samet
authors.initials: S
authors.lastname: Yalcin
authors.forename: Cüneyt
authors.initials: C
authors.lastname: Köksoy
authors.forename: Emre
authors.initials: E
authors.lastname: Ergül
authors.forename: Emine
authors.initials: E
authors.lastname: Demirel
authors.forename: Bülent
authors.initials: B
authors.lastname: Yalcin
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D019821:Simvastatin / Q000494:pharmacology*; D019284:Thapsigargin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D008055:Lipids; D019284:Thapsigargin; D019821:Simvastatin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases