title: Subtraction elastography for the evaluation of ablation-induced lesions: a feasibility study.
abstract: Different noninvasive or minimally invasive therapeutic ablation procedures can produce tissue necrosis associated with local-stiffness increase. Although elastography has been proved as a potential evaluation tool for many kinds of ablation-induced lesions, the application of subtraction technique in elastography to enhance the visualization of the ablation lesions has rarely been reported. In this paper, subtraction elastography is proposed to evaluate the ablation-induced lesions. Three models are constructed to simulate different kinds of ablated inclusions. The simulation results showed that subtraction elastography is superior to conventional elastography in detecting the ablation-induced lesions with higher signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR). The artifacts induced by elastographic signal processing algorithms can be largely reduced in subtraction elastography. In addition, subtraction elastography is less influenced by the stiff background and can provide more reliable boundary information about the lesion than conventional elastography. Furthermore, the feasibility of subtraction elastography is validated by an in vitro experiment of ethanol-induced hepatic lesions. The preliminary results of this work suggest that subtraction elastography may be a good option for the evaluation of ablationinduced lesions.
authors.affiliation: Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, PR China. deabj@tsinghua.edu.cn
authors.forename: Jinhua
authors.initials: J
authors.lastname: Shao
authors.forename: Jinrui
authors.initials: J
authors.lastname: Wang
authors.forename: Yizhuo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ligang
authors.initials: L
authors.lastname: Cui
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Bai
mesh_terms: D055011:Ablation Techniques / Q000009:adverse effects*; D000465:Algorithms; D016477:Artifacts; D003198:Computer Simulation; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005240:Feasibility Studies; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D009336:Necrosis / Q000000981:diagnostic imaging; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D013382:Subtraction Technique; D014159:Transducers