Alkylating ability of artemisinin after Cu(I)-induced activation.
The reductive activation of artemisinin by copper(I)-dipyrrin or copper(I)-(2-Clip-Phen) complexes generates an artemisinin derived alkylating species leading to covalent artemisinin-copper complex adducts. The reactivity of the peroxide function of artemisinin toward Cu(I) complexes is similar to that of Fe(II) analogues, even though the reaction is more sluggish and product distribution slightly different.
Bousejra-El Garah
Fatima
F
Laboratoire de Chimie de Coordination du CNRS, Toulouse cedex 4, France.
Pitié
Marguerite
M
Vendier
Laure
L
Meunier
Bernard
B
Robert
Anne
A
D000477:Alkylating Agents / Q000737:chemistry*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry*; D037621:Artemisinins / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005978:Glutathione / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012492:Salts / Q000737:chemistry
D000477:Alkylating Agents; D000890:Anti-Infective Agents; D037621:Artemisinins; D012492:Salts; D003300:Copper; C031327:artemisinin; D005978:Glutathione