title: The impact of sleep deprivation on the coronary circulation.
abstract: Epidemiologic studies have reported that sleep deprivation is associated with cardiovascular events. However, it remains unknown how sleep deprivation affects the coronary circulation. We assessed the impact of sleep deprivation on the coronary circulation using coronary flow velocity reserve (CFVR) measurements with transthoracic Doppler echocardiography. We studied 26 healthy male volunteers. Each subject's CFVR was measured in the morning after sleep deprivation (less than 4 h) or normal sleep (more than 7 h) on different days. Sleep durations were 3.7 ± 0.9 h (sleep deprivation) and 7.1 ± 0.2 h (normal sleep). CFVR after sleep deprivation was significantly lower than that after normal sleep (3.3 ± 0.6 versus 4.2 ± 0.9, p<0.001). Short sleep duration attenuated CFVR compared with normal sleep duration. This finding suggests that sleep deprivation might serve as a trigger for cardiovascular events.
authors.forename: Tai
authors.initials: T
authors.lastname: Sekine
authors.forename: Masao
authors.initials: M
authors.lastname: Daimon
authors.forename: Rei
authors.initials: R
authors.lastname: Hasegawa
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Toyoda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kawata
authors.forename: Nobusada
authors.initials: N
authors.lastname: Funabashi
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000328:Adult; D003326:Coronary Circulation / Q000502:physiology*; D006801:Humans; D008297:Male; D012892:Sleep Deprivation / Q000503:physiopathology*