title: Effect of antimicrobial periodontal treatment and maintenance on serum adiponectin in type 2 diabetes mellitus.
abstract: OBJECTIVE
  The aims of this study were to evaluate the effect of mechanical periodontal treatment with local application of minocycline (APT) on serum adiponectin as a marker of insulin resistance improvement in type 2 diabetes mellitus (T2DM) patients and to investigate if effect of APT on serum adiponectin level was sustained by periodontal maintenance (PM).
  
  
  METHODS
  Twenty-seven T2DM patients were randomly assigned into test or control groups. Test received scaling with ultrasonic devices at baseline and APT biweekly for 2 months while control received scaling at baseline and mechanical tooth cleaning (MPT) at the same interval. At 6 months, all patients received mechanical tooth cleaning as PM. Periodontal examination and blood measurements were performed at baseline, 4 and 9 months.
  
  
  RESULTS
  Adiponectin concentrations in test had significantly increased by 31.4% after APT (p=0.024) and by 30.4% after PM (p=0.002) compared with baseline. The percentage of >or=4 mm probing depths (PD) had shown 8.3% and 9.3% reduction after APT and PM (p=0.046, 0.02) in test while 5.0% reduction after MPT in control group (p=0.031).
  
  
  CONCLUSIONS
  Our results suggested that APT and PM not only improve periodontal disease but also increase serum adiponectin in T2DM patients.
authors.affiliation: Divison of Preventive Dentistry, Department of Oral Health Science, Graduate School of Medical and Dental Sciences, Niigata University, Gakkocho-Dori Niigata, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Soda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirayama
authors.forename: Najith
authors.initials: N
authors.lastname: Amarasena
authors.forename: Yoshifusa
authors.initials: Y
authors.lastname: Aizawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Miyazaki
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000287:Administration, Topical; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D012534:Dental Scaling / Q000295:instrumentation*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D008911:Minocycline / Q000008:administration & dosage*; D010518:Periodontitis / Q000150:complications / Q000188:drug therapy / Q000628:therapy*; D014464:Ultrasonic Therapy / Q000295:instrumentation
chemical_list: D052242:Adiponectin; D000900:Anti-Bacterial Agents; D008911:Minocycline