title: [Disease gene screening of known loci in a Chinese family with autosomal dominant retinitis pigmentosa].
abstract: OBJECTIVE
  To map the disease-causing gene in a Chinese family with autosomal dominant retinitis pigmentosa.
  
  
  METHODS
  Twenty-seven micro-satellite markers were randomly selected from the region around the known loci of causative genes, and haplotypes were determined by ABI3100 genetic analyzer. Two-point linkage analysis was performed using MLINK.
  
  
  RESULTS
  The Lod score of each marker vs adRP was below 1.
  
  
  CONCLUSIONS
  The phenotype of this family may not be caused by mutation of the known disease-causing genes.
authors.affiliation: Department of Pathobiology, Chongqing Medical University, Chongqing, 400016 PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Lu
authors.forename: Li-feng
authors.initials: LF
authors.lastname: Qia
authors.forename: Zhi-quan
authors.initials: ZQ
authors.lastname: Sha
authors.forename: Xia-oqi
authors.initials: XO
authors.lastname: Liu
authors.forename: Shi
authors.initials: S
authors.lastname: Ma
authors.forename: Xin
authors.initials: X
authors.lastname: Tang
authors.forename: Jin-xia
authors.initials: JX
authors.lastname: Chang
authors.forename: Zheng-lin
authors.initials: ZL
authors.lastname: Yang
authors.forename: Bin
authors.initials: B
authors.lastname: Ye
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D012174:Retinitis Pigmentosa / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology