Evaluation of three commercial latex agglutination kits and a commercial enzyme immunoassay for the detection of cryptococcal antigen.
We compared the performance of the Meridian CALAS, Wampole Crypto-LA, Murex Cryptococcus latex agglutination assay, and the Meridian Premier EIA for the detection of cryptococcal antigen in serum and CSF. The assays demonstrated similar performance characteristics based on concordance values > or = 93% but important differences were noted in endpoint titers.
Babady
Ngolela Esther
NE
Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Bestrom
Jean E
JE
Jespersen
Deborah J
DJ
Jones
Mary F
MF
Beito
Elaine M
EM
Binnicker
Matthew J
MJ
Wengenack
Nancy L
NL
D000946:Antigens, Fungal / Q000032:analysis*; D019411:Clinical Laboratory Techniques / Q000379:methods*; D003453:Cryptococcosis / Q000175:diagnosis*; D007124:Immunoenzyme Techniques / Q000379:methods; D007841:Latex Fixation Tests / Q000379:methods; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry* / Q000382:microbiology
D000946:Antigens, Fungal; D011933:Reagent Kits, Diagnostic