Phenylpropanoid and lignan derivatives from Antiaris toxicaria and their effects on proliferation and differentiation of an osteoblast-like cell line.
Antiarisin A and B (1 and 2), together with seventeen known compounds (3-19), were isolated from the EtOAc extract of the stem of Antiaris toxicaria Lesch. Their structures were determined on the basis of spectroscopic analyses and chemical methods. Most of the compounds were reported for the first time from the Antiaris genus and firstly studied for their proliferative and differentiative activity on osteoblast-like cells. Screening results indicated that, at the concentration of 10(-8) M, benzofuran lignans 5, 6, 11 and 13 could significantly stimulate the proliferation of UMR106 cells, while 8, 9, 11, 14, 15 and 17 could enhance ALP (alkaline phosphatase) activity.
Jiang
Miao-Miao
MM
Central Laboratory of Guangdong Pharmaceutical University, Guangzhou, PR China.
Gao
Hao
H
Dai
Yi
Y
Zhang
Xue
X
Wang
Nai-Li
NL
Yao
Xin-Sheng
XS
D000818:Animals; D031621:Antiaris / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004958:Estradiol; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010006:Osteoblasts; D020005:Propanols / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D020005:Propanols; D004958:Estradiol