Nanoparticle-enhanced fluorescence imaging of latent fingerprints reveals drug abuse.
No sweat! The sweat in a latent fingerprint (LFP) can contain orally ingested drugs and their metabolites. In a new method for drug detection, primary antibodies (Abs) against drug metabolites are conjugated to magnetic nanoparticles (NPs). The LFP is incubated with the NPs, excess particles removed, and the LFP treated with a fluorescently labeled secondary antibody. Fluorescence imaging then allows characterization.
Wolfbeis
Otto S
OS
Institute of Analytical Chemistry, Chemo- and Biosensors, University of Regensburg, 93040 Regensburg, Germany. Otto.Wolfbeis@chemie.uni-r.de
D000906:Antibodies / Q000737:chemistry / Q000276:immunology; D015374:Biosensing Techniques / Q000379:methods; D003878:Dermatoglyphics; D005453:Fluorescence; D019084:Fluorescent Antibody Technique, Indirect; D013287:Illicit Drugs / Q000032:analysis / Q000378:metabolism; D008280:Magnetics; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry*; D019966:Substance-Related Disorders / Q000175:diagnosis*
D000906:Antibodies; D013287:Illicit Drugs