Glycolic acid modulates the mechanical property and degradation of poly(glycerol, sebacate, glycolic acid).
The development of biodegradable materials with controllable degradation properties is beneficial for a variety of applications. Poly(glycerol-sebacate) (PGS) is a promising candidate of biomaterials; so we synthesize a series of poly(glycerol, sebacate, glycolic acid) (PGSG) with 1:2:0, 1:2:0.2, 1:2:0.4, 1:2:0.6, 1:2:1 mole ratio of glycerol, sebacate, and glycolic acid to elucidate the relation of doped glycolic acid to the degradation rate and mechanical properties. The microstructures of the polymers with different doping of glycolic acid were dissimilar. PGSG with glycolic acid in the ratio of 0.2 displayed an integral degree of ordering, different to those with glycolic acid in the ratio of 0, 0.4, 0.6, and 1, which showed mild phase separation structure. The number, DeltaH(m), and temperature of the PGSG melting peaks tended to decrease with the increasing ratio of doped glycolic acid. In vitro and in vivo degradation tests showed that the degradation rate of PGSG with glycolic acid in the ratio of 0.2 was slowest, but in the ratio range of 0, 0.4, and 0.6, the degradation rate increased with the increase of glycolic acid. All PGSG samples displayed good tissue response and anticoagulant effects. Our data suggest that doping glycolic acid can modulate the microstructure and degree of crosslinking of PGS, thereby control the degradation rate of PGS.
Sun
Zhi-Jie
ZJ
Center for Biomedical Materials and Engineering, Harbin Engineering University, Harbin 150001, People's Republic of China. zhijiesun2005@yahoo.com.cn
Wu
Lan
L
Huang
Wei
W
Chen
Chang
C
Chen
Yan
Y
Lu
Xi-Li
XL
Zhang
Xiao-Lan
XL
Yang
Bao-Feng
BF
Dong
De-Li
DL
D000818:Animals; D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D003651:Decanoates / Q000737:chemistry*; D055119:Elastic Modulus / Q000187:drug effects; D005898:Glass; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry; D006016:Glycolates / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D020007:Implants, Experimental; D008422:Materials Testing; D055595:Mechanical Phenomena / Q000187:drug effects*; D008970:Molecular Weight; D010973:Platelet Adhesiveness / Q000187:drug effects; D011091:Polyesters / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013927:Thrombosis / Q000473:pathology; D014914:Whole Blood Coagulation Time; D014961:X-Ray Diffraction
D003651:Decanoates; D006016:Glycolates; D011091:Polyesters; D011108:Polymers; C469892:poly(glycerol-sebacate); C547083:poly(glycerol-sebacate-glycolic acid); C031149:glycolic acid; D005990:Glycerol