title: High-resolution computed tomographic imaging of airways in sarcoidosis patients with airflow obstruction.
abstract: OBJECTIVE
  To investigate airway involvement in patients with pulmonary sarcoidosis and airflow obstruction (AO) using high-resolution computed tomography.
  
  
  METHODS
  Forty-two sarcoidosis patients with AO and 42 matched sarcoidosis patients without AO were retrospectively analyzed. High-resolution computed tomographic patterns of airway involvement were bronchial distortion, peribronchovascular thickening, small airway obstruction, and bronchial compression by enlarged lymph nodes.
  
  
  RESULTS
  Interobserver agreement was good (kappa > 0.8). High-resolution computed tomographic patterns of airway involvement were found more frequently, scored higher, and were more often multiple (P < 0.05) in patients with AO than those without. Functional improvement under treatment was observed more frequently in patients with predominant peribronchovascular thickening compared with patients with predominant bronchial distortion (P < 0.03).
  
  
  CONCLUSIONS
  In pulmonary sarcoidosis patients with AO, high-resolution computed tomography is a reliable tool to identify underlying airways involvements, which are often multiple, and enables prediction of the therapeutic response.
authors.affiliation: Université Paris 13, Service de Pneumologie, Hôpital Avicenne, Bobigny Cedex, France. jean-marc.naccache@avc.aphp.fr
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Naccache
authors.forename: Armelle
authors.initials: A
authors.lastname: Lavolé
authors.forename: Hilario
authors.initials: H
authors.lastname: Nunes
authors.forename: Christine
authors.initials: C
authors.lastname: Lamberto
authors.forename: Philippe
authors.initials: P
authors.lastname: Letoumelin
authors.forename: Michel
authors.initials: M
authors.lastname: Brauner
authors.forename: Dominique
authors.initials: D
authors.lastname: Valeyre
authors.forename: Pierre Yves
authors.initials: PY
authors.lastname: Brillet
mesh_terms: D000402:Airway Obstruction / Q000150:complications* / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement / Q000379:methods*; D015203:Reproducibility of Results; D017565:Sarcoidosis, Pulmonary / Q000150:complications* / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*