title: Standards of care for patients with invasive fungal infections within the United Kingdom: a national audit.
abstract: OBJECTIVE
  The objective of this study was to audit the compliance and implementation of the British Society for Medical Mycology standards of care for patients with invasive infections in UK hospitals.
  
  
  METHODS
  A multidisciplinary audit questionnaire regarding the processing of microbiology and histopathology specimens, radiology imaging and clinical management of patients with invasive fungal infections was distributed to UK hospitals.
  
  
  RESULTS
  The study has shown that speciation of Candida and Aspergillus isolates from sterile sites was performed in 42-98% of hospitals. Microscopy of bronchoscopy specimens was not undertaken in 13 of 62 (21%) laboratories. Cryptococcal culture and antigen were undertaken routinely in abnormal CSF in 40-75% and 31-83% of at-risk patients but only in 12% of abnormal CSFs in patients without risk factors. Detailed fungal morphology was provided by <50% of histopathology departments. Most hospitals provided a timely HRCT or MRI on patients suspected to have an invasive fungal infection, but early treatment failed to occur in 15% of hospitals. In patients presenting with candidaemia, central venous catheters (CVC) were not changed routinely within 48h in 15%.
  
  
  CONCLUSIONS
  Improvement in microbiology and histopathology specimen processing as well as rapid interventions such as initiation of anti-fungal therapy or CVC line removal could improve diagnostic rates and clinical outcomes of invasive fungal infections.
authors.affiliation: Department of Microbiology, Norfolk and Norwich University Hospital, Norwich, United Kingdom. sschelenz@doctors.org.uk
authors.forename: S
authors.initials: S
authors.lastname: Schelenz
authors.forename: R A
authors.initials: RA
authors.lastname: Barnes
authors.forename: C C
authors.initials: CC
authors.lastname: Kibbler
authors.forename: B L
authors.initials: BL
authors.lastname: Jones
authors.forename: D W
authors.initials: DW
authors.lastname: Denning
mesh_terms: D005658:Fungi / Q000145:classification / Q000302:isolation & purification; D006302:Health Services Research; D006801:Humans; D009181:Mycoses / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D011795:Surveys and Questionnaires; D006113:United Kingdom