title: Functions and regulatory mechanisms of Gq-signaling pathways.
abstract: Gq family members of heterotrimeric G protein activate beta isoforms of phospholipase C that hydrolyzes phosphatidylinositol phosphate to diacylglycerol and inositol trisphosphate, leading to the protein kinase C activation and intracellular Ca(2+) mobilization, respectively. To understand the functions and regulatory mechanisms of Gq-signaling pathways, we first introduce the Galphaq-interacting proteins, which function as the effectors and the modulators of Gq. Next, we describe the Pasteurella multocida toxin and YM-254890, which are useful tools to investigate Gq signaling as activator and inhibitor, respectively. Finally, we discuss the physiological function of Gq in developmental brain, especially in neural progenitor cells.
authors.affiliation: Department of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan.
authors.forename: Norikazu
authors.initials: N
authors.lastname: Mizuno
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000633:toxicity; D001427:Bacterial Toxins / Q000633:toxicity; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D017173:Caenorhabditis elegans; D020555:GTP-Binding Protein Regulators / Q000378:metabolism; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000378:metabolism; D010456:Peptides, Cyclic / Q000633:toxicity; D020836:Protein Structure, Quaternary; D015398:Signal Transduction / Q000187:drug effects; D013234:Stem Cells / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D020555:GTP-Binding Protein Regulators; C062258:Pasteurella multocida toxin; D010456:Peptides, Cyclic; C475455:YM-254890; D043802:GTP-Binding Protein alpha Subunits, Gq-G11