title: Efficacy of combination chemotherapy for treatment of gastrointestinal lymphoma in dogs.
abstract: BACKGROUND
  Chemotherapy for multicentric canine lymphoma has favorable results. The gastrointestinal (GI) tract is the most common extranodal site of canine lymphoma, but there have been no prospective studies to determine outcome when dogs with GI lymphoma are treated with chemotherapy.
  
  
  OBJECTIVE
  Treatment with a multiagent chemotherapy protocol is associated with a poor outcome in dogs with GI lymphoma.
  
  
  METHODS
  Eighteen dogs with histologically confirmed GI lymphoma.
  
  
  METHODS
  Prospective clinical trial in which dogs with GI lymphoma were treated with a 20-week combination chemotherapy protocol consisting of induction and consolidation phases.
  
  
  RESULTS
  Thirteen dogs had primary GI lymphoma and 5 had multicentric lymphoma with GI involvement. The majority of the lymphomas (63%) were of T-cell origin. Overall remission rate was 56%; 9 dogs achieved a complete remission for a median of 86 days (range, 22-420 days) and 1 dog achieved a partial remission for 26 days. Overall median survival time was 77 days (range, 6-700 days). Dogs that failed to achieve a remission (10 versus 117 days; P= .002) or had diarrhea at initial presentation (70 versus 700 days; P < .001) had shorter survival times.
  
  
  CONCLUSIONS
  The response and survival of dogs with GI lymphoma treated with multiagent chemotherapy is poor but long-term survival is possible.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, PO Box 31, Ithaca, NY 14853, USA. kmr32@cornell.edu
authors.forename: K M
authors.initials: KM
authors.lastname: Rassnick
authors.forename: A S
authors.initials: AS
authors.lastname: Moore
authors.forename: K E
authors.initials: KE
authors.lastname: Collister
authors.forename: N C
authors.initials: NC
authors.lastname: Northrup
authors.forename: O
authors.initials: O
authors.lastname: Kristal
authors.forename: J D
authors.initials: JD
authors.lastname: Chretin
authors.forename: D B
authors.initials: DB
authors.lastname: Bailey
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001216:Asparagine / Q000008:administration & dosage; D001772:Blood Cell Count / Q000662:veterinary; D003520:Cyclophosphamide / Q000008:administration & dosage; D004283:Dog Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008130:Lomustine / Q000008:administration & dosage; D008223:Lymphoma / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011446:Prospective Studies; D012074:Remission Induction; D015996:Survival Rate; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D001216:Asparagine; D008130:Lomustine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone