Levels of Transcripts Encoding a Member of the Protein Kinase C Family in the Paraventricular and Supraoptic Nuclei are Increased by Hyperosmolality.
The distribution of mRNA transcripts for the six known protein kinase C (PKC) genes has been investigated by quantitative in situ hybridization histochemistry. PKC-delta transcripts were detected only in the thalamus and PKC-zeta was found in several areas including the supraoptic (SON) and paraventricular (PVN) nuclei. Activation of magnocellular cells in the SON and PVN following 7 days of saline-loading resulted in increased levels of PKC-zeta transcripts in both of these nuclei.
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