title: [Development of the role of micrornas regulation in osteogenesis].
abstract: OBJECTIVE
  To review the progress, controversy and trend in the regulation and mechanism of the microRNAs (miRNAs) during the osteogenesis.
  
  
  METHODS
  Recent literature concerning regulation and mechanism of the miRNAs during the osteogenesis was extensively reviewed, summarized and analyzed.
  
  
  RESULTS
  Recently miRNAs was a hot topic for osteogenesis. More and more materials showed its important role in ossification, but its definite mechanism was not clear.
  
  
  CONCLUSIONS
  Osteogenesis can be strengthened by miRNAs technology, which has a bright future and may also provide the molecular mechanism. The study on miRNAs of osteogenesis can provide a model to analyze and compare the osteogenetic effects of novel drugs.
authors.affiliation: Department of Joint Surgery, First Affiliated Hospital of Zhongshan University, Guangzhou Guangdong, 510080, P.R. China.
authors.forename: Zihong
authors.initials: Z
authors.lastname: Lin
authors.forename: Senhao
authors.initials: S
authors.lastname: Lin
authors.forename: Yingxiong
authors.initials: Y
authors.lastname: Huang
authors.forename: Junlong
authors.initials: J
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Fu
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D035683:MicroRNAs; D010006:Osteoblasts / Q000166:cytology*; D010012:Osteogenesis / Q000235:genetics*
chemical_list: D035683:MicroRNAs