[The clinicopathological study of infantile cytomegalovirus hepatitis].
OBJECTIVE
To investigate the clinicopathological features of infantile cytomegalovirus hepatitis.


METHODS
Liver biopsies from 30 cases of infantile cytomegalovirus hepatitis were observed under optical microscope and electronic microscope.


RESULTS
The main clinical manifestations were jaundice, splenohepatomegaly and hypohepatia. Laboratory test showed dysfunction of liver, high level of CMV DNA, and high titer of anti-CMV antibody. Imaging examination demonstrated hepatomegaly. The histological changes were hepatocellular degeneration, necrosis, apoptosis, and fibrosis. The histological characteristics of cytomegalovirus hepatitis, including intranuclear inclusions in multinucleated giant cells and pseudo-lumens, were also observed under optical microscope. In addition, virion was observed in the nuclei and cytoplasm of hepatocytes under electronic microscope.


CONCLUSIONS
The viral DNA and serological tests have limited utility for the diagnosis of infantile cytomegalovirus hepatitis, and the final diagnosis depends on histopathology.
Tang
Yuan-Ting
YT
Department of Pathology, Chongqing Medical University, Chongqing 400016, China.
Guan
Xiao-Qin
XQ
Zhao
Rui-Qiu
RQ
D001707:Biopsy, Needle; D003586:Cytomegalovirus Infections / Q000473:pathology*; D005260:Female; D006525:Hepatitis, Viral, Human / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000473:pathology; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000473:pathology*; D008297:Male; D008930:Mitochondria, Liver / Q000473:pathology / Q000648:ultrastructure