title: Clinical and serological correlates of anti-Sm autoantibodies in Chinese patients with systemic lupus erythematosus: 1,584 cases.
abstract: To investigate the association of anti-Sm antibodies with clinical and serological features in systemic lupus erythematosus. A group of 1,584 patients with SLE was recruited. Clinical and laboratory data were compared between patients with and without anti-Sm antibodies. There were 1,424 females and 160 males, the mean age of the patients was 33.2 +/- 12.3 years, and the mean duration of disease was 32.5 +/- 59.4 months. A total of 469 (29.6%) were anti-Sm antibodies positive. The presence of anti-Sm antibodies was associated with arthritis, renal involvement, malar rash, vasculitis and low serum complement C3. The positive rate of anti-nuclear, anti-dsDNA, anti-La/SSB and anti-U1RNP antibodies were significant higher in anti-Sm positive group when compared with anti-Sm negative group. A trend towards a higher presence of anti-Sm antibodies related to an early disease onset was observed. In conclusion, Anti-Sm antibodies are associated with lupus related clinical and laboratory profiles and correlated significantly with disease activity.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Guangdong Medical College, Dongguan, China.
authors.forename: Jin Dong
authors.initials: JD
authors.lastname: Ni
authors.forename: Xi
authors.initials: X
authors.lastname: Yao
authors.forename: Hai Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Xiang Pei
authors.initials: XP
authors.lastname: Li
authors.forename: Jian Hua
authors.initials: JH
authors.lastname: Xu
authors.forename: Dong Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055517:snRNP Core Proteins / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D055517:snRNP Core Proteins