[Diffuse interstitial lung disease related to peribronchiolar metaplasia].
Peribronchiolar metaplasia is a histologic lesion characterized by fibrosis and bronchiolar epithelial proliferation, affecting peribronchiolar alveolar septa and terminal bronchioles. It has been considered a nonspecific tissue reaction secondary to the action of external factors, such as tobacco smoke and microbes, and is a common histologic finding in several diffuse interstitial lung diseases. Several such cases with clinical, radiologic, and lung function manifestations characteristic of idiopathic interstitial pneumonia have been described recently, all having peribronchiolar metaplasia as the only histologic abnormality. We report 2 cases of interstitial lung disease in which peribronchiolar metaplasia was the only finding of pathology.
Cano-Jiménez
Esteban
E
Servicio de Neumología, Hospital Clínic, Universitat de Barcelona, Barcelona, España. estebanmallorca@gmail.com
Molina-Molina
María
M
Ramírez
José
J
Sánchez
Marcelo
M
Aliaga
Joan Lluis
JL
Xaubet
Antoni
A
D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology*; D017563:Lung Diseases, Interstitial / Q000209:etiology*; D008297:Male; D008679:Metaplasia / Q000150:complications; D008875:Middle Aged