title: Antagonists of the P2X(7) receptor. From lead identification to drug development.
authors.affiliation: Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK. simon.guile@astrazeneca.com
authors.forename: Simon D
authors.initials: SD
authors.lastname: Guile
authors.forename: Lilian
authors.initials: L
authors.lastname: Alcaraz
authors.forename: Timothy N
authors.initials: TN
authors.lastname: Birkinshaw
authors.forename: Keith C
authors.initials: KC
authors.lastname: Bowers
authors.forename: Mark R
authors.initials: MR
authors.lastname: Ebden
authors.forename: Mark
authors.initials: M
authors.lastname: Furber
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Stocks
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000578:Amidines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001393:Azoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery; D006801:Humans; D058919:Purinergic P2 Receptor Antagonists; D058486:Receptors, Purinergic P2X7; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000578:Amidines; D001393:Azoles; C546468:P2RX7 protein, human; D058919:Purinergic P2 Receptor Antagonists; D058486:Receptors, Purinergic P2X7