A Feedforward-Feedback Glucose Control Strategy for Type 1 Diabetes Mellitus.
As the "artificial pancreas" becomes closer to reality, automated insulin delivery based on real-time glucose measurements becomes feasible for people with diabetes. This paper is concerned with the development of novel feedforward-feedback control strategies for real-time glucose control and type 1 diabetes. Improved post-meal responses can be achieved by a pre-prandial snack or bolus, or by reducing the glucose setpoint prior to the meal. Several feedforward-feedback control strategies provide attractive alternatives to the standard meal insulin bolus and are evaluated in simulations using a physiological model.
Marchetti
Gianni
G
DIPIC-Department of Chemical Engineering Principles and Practice, Università di Padova, via Marzolo 9, 35131 Padova (Italy).
Barolo
Massimiliano
M
Jovanovič
Lois
L
Zisser
Howard
H
Seborg
Dale E
DE