title: Synthesis of (E)- and (Z)-alpha,beta-Difluorourocanic Acid.
abstract: Horner-Emmons fluoroolefination of an aryl aldehyde followed by introduction of a second fluorine via "FBr" addition provides an original approach to the preparation of 1-alkyl-2-aryl-1,2-difluoroethenes. The utility of this procedure is demonstrated by the preparation of (E and Z)-alpha,beta-difluorourocanic acid.
authors.affiliation: Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
authors.forename: Jan
authors.initials: J
authors.lastname: Hajduch
authors.forename: Bohumil
authors.initials: B
authors.lastname: Dolenský
authors.forename: Shinichi
authors.initials: S
authors.lastname: Yoshida
authors.forename: Junfa
authors.initials: J
authors.lastname: Fan
authors.forename: Kenneth L
authors.initials: KL
authors.lastname: Kirk