Mononuclear copper(II)-superoxo complexes that mimic the structure and reactivity of the active centers of PHM and DbetaM.
Mononuclear copper(II)-superoxo complexes 2(X)-OO(*) having triplet (S = 1) ground states were obtained via reaction of O(2) with the copper(I) starting materials 1(X) supported by tridentate ligands L(X) [1-(2-p-X-phenethyl)-5-(2-pyridin-2-ylethyl)-1,5-diazacyclooctane; X = CH(3), H, NO(2)] in various solvents. The superoxo complexes 2(X)-OO(*) mimic the structure [tetrahedral geometry with an end-on (eta(1))-bound O(2)(*-)] and the aliphatic C-H bond activation chemistry of peptidylglycine alpha-hydroxylating monooxygenase and dopamine beta-monooxygenase.
Kunishita
Atsushi
A
Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
Kubo
Minoru
M
Sugimoto
Hideki
H
Ogura
Takashi
T
Sato
Kazunobu
K
Takui
Takeji
T
Itoh
Shinobu
S
D040761:Biomimetic Materials / Q000737:chemistry*; D020134:Catalytic Domain; D003300:Copper / Q000737:chemistry*; D034242:Cyclooctanes / Q000737:chemistry; D004299:Dopamine beta-Hydroxylase / Q000737:chemistry* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D008024:Ligands; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry*
D034242:Cyclooctanes; D008024:Ligands; D009097:Multienzyme Complexes; D009942:Organometallic Compounds; D013481:Superoxides; D003300:Copper; D006899:Mixed Function Oxygenases; D004299:Dopamine beta-Hydroxylase; C035189:peptidylglycine monooxygenase