title: Influence of the site of lobectomy and chronic obstructive pulmonary disease on pulmonary function: a follow-up analysis.
abstract: The aim of this retrospective study was to evaluate the influence of the site of lobectomy and the presence of chronic obstructive pulmonary disease (COPD) on pulmonary function at different postoperative periods. The patients were divided into groups of COPD and non-COPD patients, and the differences between observed and predicted postoperative values of pulmonary function at different evaluation times according to the resected lobe were assessed. The observed postoperative percentage change in FEV(1) (opo%DeltaFEV(1)) - predicted postoperative percentage change in FEV(1) (ppo%DeltaFEV(1)) one month and six months after right upper lobectomy or left upper lobectomy in COPD patients was of significantly higher positive value than in non-COPD patients. In non-COPD patients, opo%DeltaFEV(1) - ppo%DeltaFEV(1) one month and six months after surgery was of significantly higher negative value in those who had right upper lobectomy than in those who had right lower lobectomy or left lower lobectomy (P<0.05). COPD may strongly influence pulmonary function at early- and late-terms after upper lobectomy. In non-COPD patients, the site of lobectomy may strongly influence pulmonary function at early- and late-terms after surgery.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Nara Medical University School of Medicine, Kashihara, Nara, 634-8522, Japan. mdkeiji@m3.kcn.ne.jp
authors.forename: Keiji
authors.initials: K
authors.lastname: Kushibe
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: Michitaka
authors.initials: M
authors.lastname: Kimura
authors.forename: Makoto
authors.initials: M
authors.lastname: Takahama
authors.forename: Takashi
authors.initials: T
authors.lastname: Tojo
authors.forename: Shigeki
authors.initials: S
authors.lastname: Taniguchi
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000009:adverse effects; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D020127:Recovery of Function; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014797:Vital Capacity