[Expression of apoptosis and proliferation markers in progression of ovarian cancer].
Immunohistochemical investigation of intraoperative biopsy specimens of ovarian cancer at different clinical stages of the disease has revealed enhanced proliferation of the index Ki-67 and PCNA expression as well as Mt p53 and Bcl-2 expression correlating with the disease stage. Cancer progression may be accompanied with a selection of p53+ cells with hyperexpression of Bcl-2 and high proliferative activity.
Antoneeva
I I
II
Petrov
S B
SB
D017209:Apoptosis; D014408:Biomarkers, Tumor / Q000096:biosynthesis*; D049109:Cell Proliferation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53