Myeloid-derived suppressor cells as regulators of the immune system.
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.
Gabrilovich
Dmitry I
DI
Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA. dmitry.gabrilovich@moffitt.org
Nagaraj
Srinivas
S
D000818:Animals; D002465:Cell Movement; D003141:Communicable Diseases / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology; D008213:Lymphocyte Activation; D022423:Myeloid Cells / Q000276:immunology*; D038042:Myelopoiesis; D009369:Neoplasms / Q000276:immunology; D013234:Stem Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology