Effect of triterpenoid saponins from Bacopa monniera on scopolamine-induced memory impairment in mice.
Three new saponins, bacopasides IX-XI (1- 3), together with their known analogues bacopaside I (4), bacopaside II (5), bacopasaponsin C (6), and bacopasaponsin D (7), were isolated from the whole plant of Bacopa monniera. Compounds 3, 4, and 6 showed nootropic activity when tested in the Morris water maze test and step-down test of scopolamine-induced memory impairment in mice.
Zhou
Yun
Y
Zhejiang Food and Drug Administration, Hangzhou 310012, Zhejiang Province, PR China. yunzhoucn@yahoo.com.cn
Peng
Ling
L
Zhang
Wei-Dong
WD
Kong
De-Yun
DY
D000818:Animals; D034681:Bacopa / Q000737:chemistry*; D004195:Disease Models, Animal; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D018697:Nootropic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D012601:Scopolamine; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D018697:Nootropic Agents; D010936:Plant Extracts; D014315:Triterpenes; C544494:bacopaside IX; C544496:bacopaside XI; D012601:Scopolamine; C544495:bacopaside X