Intermolecular methoxycarbonylation of terminal alkynes catalyzed by palladium(II) bis(oxazoline) complexes.
Boxing clever: Direct conversion of a terminal alkyne group into a beta-methoxyacrylate is realized with the aid of the bis(oxazoline) ligand (box). Acetyl and ketal protecting groups, free hydroxy groups, and acid-sensitive glycosidic bonds are not affected under the reaction conditions. The one-pot synthesis of (+/-)-dihydrokawain from the homopropargyl alcohol is also achieved. tfa = trifluoroacetate.
Kato
Keisuke
K
Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. kkk@phar.toho-u.ac.jp
Motodate
Satoshi
S
Mochida
Tomoyuki
T
Kobayashi
Takuya
T
Akita
Hiroyuki
H
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D009944:Organoplatinum Compounds / Q000737:chemistry*
D000480:Alkynes; D009944:Organoplatinum Compounds