title: Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.
abstract: Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence of fluorotyrosine may result in an improvement of the biological properties of this lipopeptide. The fluorinated iturin might also be used as a probe for studying its interaction with biological membranes.
authors.affiliation: School of Biomolecular and Biomedical Science, Ardmore House, University College Dublin, Dublin 4, Ireland.
authors.forename: Stephen
authors.initials: S
authors.lastname: Moran
authors.forename: Dilip K
authors.initials: DK
authors.lastname: Rai
authors.forename: Benjamin R
authors.initials: BR
authors.lastname: Clark
authors.forename: Cormac D
authors.initials: CD
authors.lastname: Murphy
mesh_terms: D001412:Bacillus subtilis / Q000378:metabolism*; D005461:Fluorine / Q000737:chemistry; D055666:Lipopeptides; D010456:Peptides, Cyclic / Q000096:biosynthesis*; D014443:Tyrosine
chemical_list: D055666:Lipopeptides; D010456:Peptides, Cyclic; D005461:Fluorine; D014443:Tyrosine; C013579:iturin A