title: Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
abstract: We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues. The NP comprises three distinct functional components: (i) a hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; (ii) a hydrophilic polymeric shell with antibiofouling properties to enhance NP stability and systemic circulation half-life; and (iii) a lipid monolayer at the interface of the core and the shell that acts as a molecular fence to promote drug retention inside the polymeric core, thereby enhancing drug encapsulation efficiency, increasing drug loading yield, and controlling drug release. The NP is prepared by self-assembly through a single-step nanoprecipitation method in a reproducible and predictable manner, making it potentially suitable for scale-up.
authors.affiliation: Department of Chemical Engineering, Division of Health Science and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Liangfang
authors.initials: L
authors.lastname: Zhang
authors.forename: Juliana M
authors.initials: JM
authors.lastname: Chan
authors.forename: Frank X
authors.initials: FX
authors.lastname: Gu
authors.forename: June-Wha
authors.initials: JW
authors.lastname: Rhee
authors.forename: Andrew Z
authors.initials: AZ
authors.lastname: Wang
authors.forename: Aleksandar F
authors.initials: AF
authors.lastname: Radovic-Moreno
authors.forename: Frank
authors.initials: F
authors.lastname: Alexis
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
mesh_terms: D003460:Crystallization / Q000379:methods; D004058:Diffusion; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry*; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D050997:Nanomedicine / Q000379:methods; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010316:Particle Size; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D008055:Lipids; D046911:Macromolecular Substances; D004364:Pharmaceutical Preparations; D011108:Polymers