Suppressor of cytokine signaling 3 promotes bone marrow cells to differentiate into CD8+ T lymphocytes in lung tissue via up-regulating Notch1 expression.
Suppressor of cytokine signaling 3 (SOCS3) expression in bone marrow cells (BMC) was up-regulated upon exposure to interleukin 6, lipopolysaccharide, or tumor-associated factors. But, how the up-regulated SOCS3 affects differentiation of BMCs is incompletely characterized. Here, we showed that SOCS3 promoted BMCs to intently differentiate into CD8 T cells. Importantly, lung can be as one athymus tissue for the BMCs to differentiate into CD8(+) T cells. Notch1 plays a critical role in the differentiation from SOCS3-transfected BMCs to CD8(+) T cells. We conclude that the up-regulated SOCS3 in some pathologic conditions, such as tumor and inflammation, might promote BMCs to differentiate into CD8(+) T lymphocytes in lung tissue via up-regulating Notch1 expression. This may represent a new mechanism against diseases such as tumor.
Zhang
Zhuohan
Z
Departments of Immunology and Pathology, Nankai University School of Medicine.
Zeng
Bin
B
Zhang
Zhiqian
Z
Jiao
Guohui
G
Li
Haijie
H
Jing
Zhizi
Z
Ouyang
Jiangbo
J
Yuan
Xin
X
Chai
Limin
L
Che
Yongzhe
Y
Zhang
Yuan
Y
Yang
Rongcun
R
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000187:drug effects / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D002460:Cell Line; D018920:Coculture Techniques; D005260:Female; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000276:immunology; D015850:Interleukin-6 / Q000494:pharmacology; D008168:Lung / Q000276:immunology*; D008175:Lung Neoplasms / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008819:Mice, Nude; D010053:Ovary; D051881:Receptor, Notch1 / Q000235:genetics*; D017154:Stromal Cells / Q000276:immunology; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins / Q000502:physiology*
D015850:Interleukin-6; C497762:Notch1 protein, mouse; D051881:Receptor, Notch1; C491411:Socs3 protein, mouse; D000071223:Suppressor of Cytokine Signaling 3 Protein; D050826:Suppressor of Cytokine Signaling Proteins