title: Acute haemodynamic response to sleeping head-up at 6 inches in older inpatients.
abstract: OBJECTIVE
  Our aim was to investigate the effect of monotherapy of sleeping head-up (SHU) at 6 in. in a group of older inpatients with OH from all causes.
  
  
  METHODS
  We recruited nine consecutive inpatients (mean age (SD) 76(5) years) with persistent, symptomatic OH with a mean systolic blood pressure (SBP) drop on standing and nadir SBP of 68 (27.8) and 94 (19.2) mmHg respectively. All patients underwent SHU for 1 week. Beat-to-beat haemodynamics during lying and standing, 24-hour ambulatory blood pressure, supine haematocrit, urea/electrolytes, plasma renin activity and aldosterone were measured before and after intervention.
  
  
  RESULTS
  One week after SHU, SBP, stroke volume and cardiac output increased significantly (all P < 0.05) by 12 mmHg, 15 ml and 1.3 l/minutes respectively while heart rate and total peripheral resistance were significantly reduced by 3.6 bpm and 0.355 dynes/s/cm(5) respectively during 2 minute of standing. Serum creatinine was also significantly lower. Five patients improved in their mobility following SHU.
  
  
  CONCLUSIONS
  SHU for 1 week at 6 in. was well tolerated by older in-patients with OH, associated with improved orthostatic tolerance, and with haemodynamic changes in keeping with increased extracellular volume. SHU at 6 in. has a role in the acute treatment of OH for patients in hospital, but its longer-term effects and in the out-patient setting require further study.
authors.affiliation: Mercer's Institute for Research on Ageing, St James's Hospital, Dublin 8, Ireland. cfan@stjames.ie
authors.forename: Chie-Wei
authors.initials: CW
authors.lastname: Fan
authors.forename: Declan
authors.initials: D
authors.lastname: Gasparro
authors.forename: Vivion
authors.initials: V
authors.lastname: Crowley
authors.forename: Conal J
authors.initials: CJ
authors.lastname: Cunningham
mesh_terms: D000368:Aged; D005260:Female; D006257:Head; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007024:Hypotension, Orthostatic / Q000628:therapy*; D007297:Inpatients; D008297:Male; D011187:Posture / Q000502:physiology*; D012890:Sleep