A tandem triplication, trp(1)(q21q32), in a patient with follicular lymphoma: a case study and review of the literature.
A 1q triplication is a rare karyotypic event in hematologic malignancies, with 26 cases of 1q triplication reported in the literature. Although 1q duplication or triplication is present with a high incidence in Burkitt lymphoma and Fanconi anemia, there have been no detailed reports of an association between non-Burkitt type lymphomas and 1q triplication. Presented here is the case of a 69-year-old man with follicular lymphoma (FL) and 1q triplication, with a review of the pertinent literature. The patient was diagnosed with FL with bone marrow involvement; his bone marrow chromosome study revealed 50,XY,trp(1)(q21q32),+3,+add(3)(q21),+7,+9,add(13)(p11.2)[11]/51 approximately 52,idem,+19,+22[8]/46,XY[3]. Review of the Mitelman Database of Chromosome Aberrations in Cancer revealed 7 previous cases of non-Burkitt type lymphoma (including FL) with 1q triplication. On the basis of these eight cases, we conclude that 1q triplication represents a rare secondary genetic event with prognostic significance in patients with FL or other non-Burkitt types of lymphoma. Further studies are needed to investigate these rare 1q triplication in hematologic malignancies.
Park
Tae Sung
TS
Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, Korea.
Lee
Seung Tae
ST
Song
Jaewoo
J
Lee
Kyung-A
KA
Kim
Juwon
J
Kim
Sue Jung
SJ
Lee
Jung-Hoon
JH
Song
Sungwook
S
Choi
Jong Rak
JR
D000368:Aged; D002878:Chromosomes, Human, Pair 1; D020732:Cytogenetic Analysis; D020440:Gene Duplication; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D008297:Male; D020080:Tandem Repeat Sequences; D014314:Trisomy