Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung.
We present a case featuring a unique overlap between the body areas involved by lung adenocarcinoma and the cutaneous paraneoplastic sign of Leser-Trélat. In our patient, the Leser-Trélat sign consisted of explosive multiple seborrheic keratoses in combination with acanthosis nigricans, representing a remarkable geometric skin projection of lung cancer which involved both the upper lobes. Our case suggests a unique interrelation between the paraneoplastic sign of Leser-Trélat and the tumor itself. The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers.
Dasanu
Constantin A
CA
Georgetown University, Washington, DC, USA. c_dasanu@yahoo.com
Alexandrescu
Doru T
DT
D000052:Acanthosis Nigricans / Q000175:diagnosis / Q000473:pathology*; D000230:Adenocarcinoma / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D009362:Neoplasm Metastasis; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000473:pathology*