title: Angle-dependent ultrasonic detection and imaging of two types of brachytherapy seeds using singular spectrum analysis.
abstract: Brachytherapy to treat prostate cancer uses transrectal ultrasound to guide implantation of titanium-shelled radioactive seeds. Transperitoneal implantation allows errors in placement that cause suboptimal dosimetry. Conventional ultrasound cannot reliably image implanted seeds; therefore, seed misplacements cannot be corrected in the operating room. Previously, an algorithm based on singular spectrum analysis was shown to image palladium seeds better than B-mode ultrasound could. The algorithm is now applied to imaging an iodine seed in gel and in beef tissue as a function of seed angle relative to the incident ultrasound. Results indicate that both seed types are imaged reliably by the algorithm.
authors.affiliation: Frederic L Lizzi Center for Biomedical Engineering, Riverside Research Institute, New York, NY 10038, USA. mamou@rrinyc.org
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mamou
authors.forename: Sarayu
authors.initials: S
authors.lastname: Ramachandran
authors.forename: Ernest J
authors.initials: EJ
authors.lastname: Feleppa
mesh_terms: D000465:Algorithms; D000818:Animals; D001918:Brachytherapy; D002417:Cattle; D003198:Computer Simulation; D005782:Gels; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008460:Meat; D008954:Models, Biological; D010165:Palladium / Q000627:therapeutic use; D010537:Peritoneum / Q000000981:diagnostic imaging; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011868:Radioisotopes; D011879:Radiotherapy Dosage; D012815:Signal Processing, Computer-Assisted; D014463:Ultrasonography / Q000295:instrumentation
chemical_list: D005782:Gels; D007457:Iodine Radioisotopes; D011868:Radioisotopes; D010165:Palladium