title: Soy consumption and prostate cancer risk in men: a revisit of a meta-analysis.
abstract: BACKGROUND
  Epidemiologic studies have shown that the consumption of soy foods may be associated with a reduction in cancer risk in humans.
  
  
  OBJECTIVE
  The purpose of this study was to conduct a meta-analysis on the association between soy consumption and prostate cancer risk in men.
  
  
  METHODS
  We systematically reviewed studies obtained through a thorough Medline literature search and identified 15 epidemiologic publications on soy consumption and 9 on isoflavones in association with prostate cancer risk. We extracted the most adjusted relative risks (RRs) and odds ratios (ORs) of the highest and the lowest reported categories of intake from each study and conducted this analysis using a random-effects model in which studies with smaller SEEs are given greater weight in the summary measure.
  
  
  RESULTS
  Our analysis of studies on soy intake yielded a combined RR/OR of 0.74 (95% CI: 0.63, 0.89; P = 0.01). When separately analyzed, studies on nonfermented soy foods yielded a combined RR/OR of 0.70 (95% CI: 0.56, 0.88; P = 0.01) and those on fermented soy foods yielded a combined RR/OR of 1.02 (95% CI: 0.73, 1.42; P = 0.92). The analysis of studies on isoflavones yielded a combined RR/OR of 0.88 (95% CI: 0.76, 1.02; P = 0.09). Further separate analyses showed a combined RR/OR of 0.52 (95% CI: 0.34, 0.81; P = 0.01) from studies with Asian populations and 0.99 (95% CI: 0.85, 1.16; P = 0.91) from studies with Western populations.
  
  
  CONCLUSIONS
  The results of this analysis suggest that consumption of soy foods is associated with a reduction in prostate cancer risk in men. This protection may be associated with the type and quantity of soy foods consumed.
authors.affiliation: Grand Forks Human Nutrition Research Center, ARS, USDA, Grand Forks, ND 58202-9034, USA. lin.yan@ars.usda.gov
authors.forename: Lin
authors.initials: L
authors.lastname: Yan
authors.forename: Edward L
authors.initials: EL
authors.lastname: Spitznagel
mesh_terms: D001208:Asia / Q000208:ethnology; D001213:Asian; D016022:Case-Control Studies; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000208:ethnology*; D005285:Fermentation; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage* / Q000032:analysis; D008297:Male; D016017:Odds Ratio; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000208:ethnology* / Q000209:etiology; D012307:Risk Factors; D045730:Soy Foods / Q000032:analysis
chemical_list: D007529:Isoflavones