title: Post-laryngectomy stomal cancer recurrences, re-treatment decisions and outcomes: case series.
abstract: OBJECTIVE
  Post-laryngectomy stomal cancer recurrences pose management problems because aggressive therapeutic interventions have already often been employed. The purpose of this study is to describe the extent of peristomal cancer relapses, treatment decisions and patient outcomes.
  
  
  METHODS
  Of the 429 individuals who underwent total laryngectomy for laryngeal cancer between 1985 and 2005, 11 patients developed recurrent tumour in the tracheal stoma.
  
  
  RESULTS
  Using Sisson's disease classification, the lesions were assigned as type I [5 patients], II [2 patients], III [1 patient] or IV [3 patients]. Combined therapy or re-irradiation alone was administered more often to individuals with early stage disease than to patients with type III or IV recurrences. Complete resolution with local control of tumour occurred in two patients. The overall 2-year survival rate was 10%, and the median survival with and without repeated treatment was 11 months and 7 months, respectively.
  
  
  CONCLUSIONS
  Re-treatment deserves consideration in individuals with post-laryngectomy stomal cancer recurrences because salvage therapy could truly rescue patients, and progressive tracheostomal obstruction or massive hemorrhage invariably develops if the tumours are left untreated.
authors.affiliation: Division of Therapeutic Radiology, Louisiana State University Health Sciences Centre, 1501 Kings Highway, Shreveport, Louisiana 71130, USA. fampil@lsuhsc.edu
authors.forename: Federico
authors.initials: F
authors.lastname: Ampil
authors.forename: Ghali
authors.initials: G
authors.lastname: Ghali
authors.forename: Gloria
authors.initials: G
authors.lastname: Caldito
authors.forename: Roxana
authors.initials: R
authors.lastname: Baluna
mesh_terms: D000328:Adult; D000368:Aged; D003657:Decision Making; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000601:surgery*; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000628:therapy*; D009367:Neoplasm Staging; D011182:Postoperative Care; D019233:Retreatment; D012189:Retrospective Studies; D016879:Salvage Therapy; D016896:Treatment Outcome