title: Minimum inhibitory concentration of carbapenems and tigecycline against Salmonella spp.
abstract: Antimicrobial resistance in Salmonella spp. is of grave concern, more so in quinolone-resistant and extended-spectrum beta-lactamase (ESBL)-producing isolates that cause complicated infections. The MIC of azithromycin, ciprofloxacin, cefixime, cefepime, ceftriaxone, gatifloxacin, imipenem, levofloxacin, meropenem and ofloxacin (E-test strip) and tigecycline and faropenem (agar dilution) against 210 Salmonella spp. was determined. MIC(90) (defined as the antimicrobial concentration that inhibited growth of 90 % of the strains) of the carbapenems (imipenem and meropenem) for Salmonella Typhi and Salmonella Paratyphi A was 0.064 microg ml(-1). MIC(90) of faropenem was 0.25 microg ml(-1) for S. Typhi, S. Paratyphi A and Salmonella Typhimurium. The MIC(90) of azithromycin for all Salmonella spp. ranged from 8 to 16 microg ml(-1). Tigecycline showed an MIC(90) of 2 microg ml(-1) for S. Typhi, 1 microg ml(-1) for S. Paratyphi A and 4 microg ml(-1) for S. Typhimurium. We concluded that tigecycline and the carbapenems are likely to have roles in the final stage of treatment of quinolone-resistant and ESBL-producing multidrug-resistant salmonellae.
authors.affiliation: Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Malini R
authors.initials: MR
authors.lastname: Capoor
authors.affiliation: Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Deepthi
authors.initials: D
authors.lastname: Nair
authors.affiliation: Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Jitendra
authors.initials: J
authors.lastname: Posti
authors.affiliation: New Drug Discovery, Ranbaxy Research Laboratories, Gurgaon, India.
authors.forename: Smita
authors.initials: S
authors.lastname: Singhal
authors.affiliation: Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Monorama
authors.initials: M
authors.lastname: Deb
authors.affiliation: Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.
authors.forename: Pushpa
authors.initials: P
authors.lastname: Aggarwal
authors.affiliation: Department of Microbiology, Majeedia Hospital, Hamdard University, New Delhi, India.
authors.forename: Parukutty
authors.initials: P
authors.lastname: Pillai
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000382:microbiology*; D015780:Carbapenems / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D006801:Humans; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology; D012475:Salmonella / Q000187:drug effects* / Q000302:isolation & purification; D012480:Salmonella Infections / Q000382:microbiology*; D000078304:Tigecycline; D014435:Typhoid Fever / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D015363:Quinolones; D000078304:Tigecycline; D008911:Minocycline