title: Total synthesis of (+/-)-neovibsanin B.
abstract: (+/-)-Neovibsanin B was synthesized based on a DMI-accelerated intramolecular Diels-Alder reaction followed by oxy-Michael addition-lactonization. The synthetic (+/-)-neovibsanin B induced similar morphological changes in NGF-mediated PC12 cells compared with natural (+)-neovibsanin B.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cyo, Tokushima 770. imagawa@ph.bunri-u.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imagawa
authors.forename: Hayato
authors.initials: H
authors.lastname: Saijo
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kurisaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Miwa
authors.initials: M
authors.lastname: Kubo
authors.forename: Yoshiyasu
authors.initials: Y
authors.lastname: Fukuyama
authors.forename: Mugio
authors.initials: M
authors.lastname: Nishizawa
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D013237:Stereoisomerism
chemical_list: D004224:Diterpenes; C539540:neovibsanin A; D020932:Nerve Growth Factor