Efficacy of etravirine for treatment of acute HIV meningoencephalitis.
We describe a patient with human immunodeficiency virus (HIV) and hepatitis C virus coinfection who experienced recurrent episodes of acute HIV meningoencephalitis. The addition of etravirine to the therapeutic regimen completely resolved symptoms, and HIV was no longer detected in cerebrospinal spinal fluid specimens. Etravirine has a satisfactory safety profile and, in this case, was a durable alternative therapy for HIV meningoencephalitis.
Couzigou
Carine
C
Services des Maladies Infectieuses et Tropicales and Virologie, Assistance Publique-Hôpital de Paris, Hôpital Paul Brousse, Villejuif, France. couzigou@yahoo.fr)
Seang
Sophie
S
Morand-Joubert
Laurence
L
Roque-Afonso
Anne-Marie
AM
Escaut
Lélia
L
Vittecoq
Daniel
D
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008590:Meningoencephalitis / Q000188:drug therapy*; D009570:Nitriles; D011724:Pyridazines / Q000627:therapeutic use*; D011743:Pyrimidines; D016896:Treatment Outcome
D019380:Anti-HIV Agents; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; C451734:etravirine