title: Laryngeal histoplasmosis in an immunocompetent patient from a non-endemic region: case report.
abstract: Histoplasma capsulatum infection involving the larynx is a rare manifestation, especially in immunocompetent individuals and a high index of suspicion is needed to establish the diagnosis correctly. We report a case of a 50-year-old Brazilian man who presented with progressive hoarseness and throat pain for 4 months. Laryngoscopy showed a supraglottic vegetant lesion, and the biopsies chronic granulomatous inflammation without any specific agent. A second laryngoscopy with biopsies was performed and after 17 days of incubation in specific medium, H. capsulatum was isolated. The patient was successfully treated with amphotericin B.
authors.forename: Teresa C A
authors.initials: TC
authors.lastname: Ferrari
authors.forename: João Marcos A
authors.initials: JM
authors.lastname: Soares
authors.forename: José Maria P
authors.initials: JM
authors.lastname: Salles
authors.forename: Júnia S
authors.initials: JS
authors.lastname: Handam
authors.forename: Rosana C S
authors.initials: RC
authors.lastname: Azevedo
authors.forename: Marcelo A P
authors.initials: MA
authors.lastname: Xavier
authors.forename: Luciana C
authors.initials: LC
authors.lastname: Faria
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D001938:Brazil; D006651:Histocytochemistry; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D007828:Laryngoscopy; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B