title: Antifungal triterpene glycosides from the sea cucumber Holothuria (Microthele) axiloga.
abstract: Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B ( 4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the structures of the new compounds were elucidated. Compound 2 showed significant antifungal activities against six strains (1 < or = MIC(80) < or = 4 microg/mL). The stereochemistry of holothurin B (4) isolated from the title sea cucumber was also solved through X-ray diffraction analysis.
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
authors.forename: Wei-Hua
authors.initials: WH
authors.lastname: Yuan
authors.forename: Yang-Hua
authors.initials: YH
authors.lastname: Yi
authors.forename: Ren-Xiang
authors.initials: RX
authors.lastname: Tan
authors.forename: Zeng-Lei
authors.initials: ZL
authors.lastname: Wang
authors.forename: Guo-Quan
authors.initials: GQ
authors.lastname: Sun
authors.forename: Mei
authors.initials: M
authors.lastname: Xue
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Zhang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047332:Holothuria / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D006027:Glycosides; D014315:Triterpenes; C544500:arguside F; C544499:impatienside B; C544498:pervicoside D