title: Plasma levels of matrix metalloproteinase-9 are independently associated with psychosocial factors in a middle-aged normal population.
abstract: OBJECTIVE
  To test the association between psychosocial factors and circulating levels of matrix metalloproteinase-9 (MMP-9) in a normal population sample. Psychosocial factors have been associated with inflammatory markers and are of prognostic significance for coronary artery disease (CAD). The degrading enzyme MMP-9 is upregulated in inflammatory processes and hypothesized to play a role in the rupture of atherosclerotic plaques.
  
  
  METHODS
  A total of 402 participants (50% women), aged 45 to 69 years, were drawn randomly from a normal population. Psychosocial instruments covered depression (Center for Epidemiological Studies Depression Questionnaire, CES-D), vital exhaustion, hostile affect, cynicism, mastery, self-esteem, sense of coherence (SOC), emotional support, and social integration. Plasma MMP-9 was measured by an enzyme-linked immunosorbent assay method. Linear regression models were adjusted for age, sex, known CAD, rheumatoid arthritis, cancer, cardiovascular risk factors including C-reactive protein and ongoing medication.
  
  
  RESULTS
  After full adjustment, there were independent associations of elevated MMP-9 levels with CES-D (+2.9 ng/ml per SD, p = .02), hostile affect (+3.0 ng/ml per SD, p = .02), cynicism (+3.5 ng/ml per SD, p = .006), and SOC (-2.5 ng/ml per SD, p = .046). A principal component analysis extracted three components. The first was mainly extracted from CES-D, vital exhaustion, self-esteem, mastery, and SOC; the second was mainly extracted from hostile affect and cynicism. Both were independently associated with MMP-9 (p = .02, p = .04) when run in the same model.
  
  
  CONCLUSIONS
  MMP-9 levels were associated with psychosocial factors in a middle-aged normal population sample, independently of traditional risk factors. The findings may constitute a possible link between psychosocial factors and cardiovascular risk.
authors.affiliation: Department of Medical and Health Sciences, Division of Community Medicine, Linköping University, Linköping 581 83, Sweden. peter.garvin@liu.se
authors.forename: Peter
authors.initials: P
authors.lastname: Garvin
authors.forename: Lennart
authors.initials: L
authors.lastname: Nilsson
authors.forename: John
authors.initials: J
authors.lastname: Carstensen
authors.forename: Lena
authors.initials: L
authors.lastname: Jonasson
authors.forename: Margareta
authors.initials: M
authors.lastname: Kristenson
mesh_terms: D000339:Affect; D000368:Aged; D003324:Coronary Artery Disease / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood* / Q000453:epidemiology / Q000523:psychology; D005260:Female; D006791:Hostility; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood*; D008875:Middle Aged; D011584:Psychology; D012649:Self Concept; D012944:Social Support; D011795:Surveys and Questionnaires
chemical_list: D020780:Matrix Metalloproteinase 9