title: Biphasic pulmonary blastoma with rapid progression.
abstract: We report a rare case of biphasic pulmonary blastoma (BPB) with rapid progression in a 75-year-old man. Computed tomography (CT) of the chest revealed a well-defined tumor shadow measuring 8 x 6 cm in the right upper lobe. CT-guided lung biopsy revealed malignant cells with sarcomatous elements. Right upper lobectomy and systemic lymph node dissection with chest wall resection were performed. Histopathologically, the tumor was composed of immature embryoniclike mesenchymal and epithelial components that resembled embryonic lung tissue. The final diagnosis was BPB classified as pathological stage IIB (T3N0M0). Two months later, the tumor recurred in the right supraclavicular lymph nodes. The patient died of respiratory failure due to tumor progression 7 months after surgery.
authors.affiliation: Division of Thoracic Surgery, Matsue Red Cross Hospital, 200 Horomachi, Matsue, Shimane 690-8506, Japan. ryomaedamatsue@yahoo.co.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Maeda
authors.forename: Noritaka
authors.initials: N
authors.lastname: Isowa
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Onuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Miura
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Kazumichi
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D018450:Disease Progression; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D011013:Pneumonectomy / Q000379:methods; D018202:Pulmonary Blastoma / Q000175:diagnosis* / Q000601:surgery; D013997:Time Factors; D014057:Tomography, X-Ray Computed