title: Genetic variation and association of insulin-like growth factor binding protein-3 with performance in Swine.
abstract: Genetic variation of insulin-like growth factor binding protein-3 was analyzed in 17 pig breeds (14 native Chinese and 3 European). Using PCR-single strand conformation polymorphism, we found a polymorphism in intron 2, and this SNP was the combined mutation of G897T-G903A-C911T. The Chinese breeds carried a higher TAT/TAT genotype frequency (over 50%), except for Bamei (22%), Yujiang Black (0.0%), and Erhualian (10.0%); the European breeds had a higher GGC/GGC genotype frequency (Large White 1.67%, Landrace 13.89%, Duroc 0.0%). The allelic frequency of TAT in Chinese breeds was over 50%, except for Yujiang Black (12.5%); the allelic frequency of GGC was over 50% in all European breeds. The effect of genotype on 43 performance traits was investigated in one population (Lantang x Landrace). Pigs with the TAT/TAT genotype had higher B-point and C-point back-fat thickness than pigs with the GGC/GGC genotype. The TAT/TAT pigs also scored higher in meat color than the GGC/GGC pigs. These results implied that IGFBP-3 may affect meat quality and carcass traits.
authors.affiliation: College of Food Science and Engineering, Jiangxi Agricultural University, Nanchang, Jiangxi, People's Republic of China. wwjun9999@sina.com
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wang
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Meng
authors.forename: Xiaoxiang
authors.initials: X
authors.lastname: Hu
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D001483:Base Sequence; D001947:Breeding; D005787:Gene Frequency; D005838:Genotype; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D034421:Sus scrofa / Q000235:genetics*
chemical_list: D018972:Insulin-Like Growth Factor Binding Protein 3