Synthesis of 5-(4'-carboxyphenyl)-10,15,20-tris-(4 pyridyl)-porphyrin and its peptidyl phosphonate derivatives.
The synthesis and characterization of three new 4-pyridyl porphyrin-peptidyl-phosphonate compounds, containing a diphenyl 3-pyridylmethyl-phosphonate moiety, is described in this article. Nitrogen atoms in the pyridine rings of the obtained compounds were alkylated using methyl iodide, to give additional three, water soluble derivatives of these peptidyl-porphyrin conjugates. All the synthesized compounds could serve as potential photosensitizers for the photodynamic therapy (PDT) method of tumor therapy and displayed activity as inhibitors of aminopeptidase N.
Habdas
Jan
J
Institute of Chemistry, University of Silesia, 40-006 Katowice, Poland. jhabdas@us.edu.pl
Boduszek
Bogdan
B
D018826:CD13 Antigens / Q000037:antagonists & inhibitors; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared
D017319:Photosensitizing Agents; D011166:Porphyrins; D011480:Protease Inhibitors; D018826:CD13 Antigens