title: Systematic investigation of preparing biocompatible, single, and small ZnS-Capped CdSe quantum dots with amphiphilic polymers.
abstract: The successful transfer of nanoparticles between solvents is critical for many applications. We evaluated the impact of amphiphilic polymer composition on the size, transfer efficiency, and biocompatibility of tri-n-octylphosphine oxide/hexadecylamine-stabilized semiconductor ZnS-capped CdSe and CdS-capped CdTe(x)Se(1-x) quantum dots (QDs). We also investigated the adsorption of various proteins onto the surface of these QDs and studied the effect of surface chemistry on non-specific protein binding. The results from these studies will have implications in the design of QDs and other nanoparticles for biological and biomedical applications.
authors.affiliation: Institute of Biomaterials & Biomedical Engineering, Centre for Biomaterials and Biomolecular Research, University of Toronto, Toronto, ON, Canada.
authors.forename: Robin E
authors.initials: RE
authors.lastname: Anderson
authors.forename: Warren C W
authors.initials: WC
authors.lastname: Chan
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D036103:Nanotechnology / Q000379:methods; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry*; D013499:Surface Properties; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D046911:Macromolecular Substances; D011108:Polymers; D018036:Selenium Compounds; D017967:Zinc Compounds; C058667:cadmium selenide; C044696:zinc selenide