[Progress in child epilepsy].
Child epilepsy continues to concern the researchers and the clinicians and carried out these last years of important progress as well in the genetic field, as in physiopathology, clinic and therapeutic one. The identification of new genes of epilepsy, epilepsies related to channelopathy and new phenotypes related to precise genetic mutations, constitutes a major progress of paediatric epilepsy. The debate around the role of febrile convulsions in the development of hippocampal sclerosis is started again thanks to Diffusion MRI techniques. In utero exposure to antiepileptic drugs (AED), and its effects on neurodevelopment, is a very active field of research. An exposure to a polytherapy or to valproate would increase the risk of development delay. The ketogenic diet could be an alternative therapeutic during refractory epilepsies but can have serious consequences on the growth. Temporal lobe surgery is a good therapeutic option for refractory epilepsies of the child and offers, to him, better chances of social integration.
Ben Hamouda
Ibtissem
I
Service de Neurologie, EPS Charles Nicolle, Tunis.
Mrabet
Amel
A
D017668:Age of Onset; D000927:Anticonvulsants / Q000627:therapeutic use; D002648:Child; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D055423:Diet, Ketogenic / Q000379:methods; D004827:Epilepsy / Q000175:diagnosis / Q000178:diet therapy / Q000188:drug therapy / Q000235:genetics / Q000601:surgery / Q000628:therapy*; D019317:Evidence-Based Medicine; D006801:Humans; D009154:Mutation; D010641:Phenotype; D012307:Risk Factors; D003294:Seizures, Febrile / Q000150:complications; D013702:Temporal Lobe / Q000601:surgery; D016896:Treatment Outcome
D000927:Anticonvulsants