title: Skin necrosis during oral anticoagulant long-term treatment: an atypical side.
abstract: The effectiveness of anticoagulant therapy for venous thromboembolism, with regards to both acute phase and long term prophylaxis, in patients with recurrent deep venous thrombosis (DVT) and persistence of risk factors, has been confirmed by many studies. However, it is not free of complications such as hemorrhage or, more rarely, skin necrosis. The patient, observed by us since 1994, was treated with oral vitamin K antagonists: he was affected by post-thrombotic syndrome and deficiency of congenital procoagulant factors (factor II heterozygote and MTHFR positive heterozygote) and secondary deficiency of procoagulant factors due to the consumption of protein C, with appearance of skin necrosis that occurred after many years of oral anticoagulant treatment. The change of therapy from oral anticoagulant to low molecular weight heparin and the use of local dressing, led to the resolution of the clinical symptoms and on to healing.
authors.affiliation: Department of Angiology, S.Giovanni Hospital, Rome, Italy. antignani@mclink.it
authors.forename: P L
authors.initials: PL
authors.lastname: Antignani
authors.forename: I
authors.initials: I
authors.lastname: Schacther
authors.forename: C
authors.initials: C
authors.lastname: Allegra
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001728:Dicumarol / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D008297:Male; D009336:Necrosis / Q000139:chemically induced; D012867:Skin / Q000473:pathology*; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D001728:Dicumarol