[Results of using biocoating by means of the amniotic sac. Communication 1. Keratoplasty with graft biocoating].
To protect a corneal graft at keratoplasty from tear moisture hyperhydration of the de-epithelized surface and from the negative exposure to contact with the eyelid mucosa in order to enhance surgical efficiency, the authors have developed a few biocoating technologies that involve amnionic sac placement on the graft, with its fixation on the eye of a recipient, by applying a full-thickness and layered corneal disc autologous flap or a ring-shaped allogenic corneoscleral one. Fifty-two patients (55 eyes) with primary (n=5) and secondary (n=33) corneal dystrophy and leukomas (n=14) were operated on. Penetrating keratoplasty and layer-by-layer grafting were performed in 38 (40 eyes) and 14 (15 eyes) patients, respectively. The biocoat was removed from the graft following 5-7 days; by that time complete epithelization of its anterior surface occurred in the majority of patients. After penetrating keratoplasty and layer-by-layer grafting, there was a transparent engraftment in 92.5 and 93.3% of patients, respectively. Visual acuity up to 0.2-0.6 restored in 74.5% of patients.
Ivanova
O V
OV
Stepanov
V K
VK
Malov
I V
IV
Malov
V M
VM
Masaud
Iu
Iu
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000650:Amnion / Q000637:transplantation*; D003317:Corneal Dystrophies, Hereditary / Q000601:surgery*; D003318:Corneal Opacity / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000379:methods*; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D013524:Surgical Flaps; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity