title: Incidence of bacterial meningitis (2001-2005) in Lazio, Italy: the results of a integrated surveillance system.
abstract: BACKGROUND
  Monitoring the incidence of bacterial meningitis is important to plan and evaluate preventive policies. The study's aim was to estimate the incidence of bacterial meningitis by aetiological agent in the period 2001-2005, in Lazio Italy (5.3 mln inhabitants).
  
  
  METHODS
  Data collected from four sources--hospital surveillance of bacterial meningitis, laboratory information system, the mandatory infectious diseases notifications, and hospital information system--were combined into a single archive.
  
  
  RESULTS
  944 cases were reported, 89% were classified as community acquired. S. pneumoniae was the most frequent aetiological agent in Lazio, followed by N. meningitis. Incidence of H. influenzae decreased during the period. 17% of the cases had an unknown aetiology and 13% unspecified bacteria. The overall incidence was 3.7/100,000. Children under 1 year were most affected (50.3/100,000), followed by 1-4 year olds (12.5/100,000). The percentage of meningitis due to aetiological agents included in the vaccine targets, not considering age, is 31%. Streptococcus spp. was the primary cause of meningitis in the first three months of life. The capture-recapture model estimated underreporting at 17.2% of the overall incidence.
  
  
  CONCLUSIONS
  Vaccine policies should be planned and monitored based on these results. The integrated surveillance system allowed us to observe a drop in H. influenzae b meningitis incidence consequent to the implementation of a mass vaccination of newborns.
authors.affiliation: Agency for Public Health, Lazio Region, Rome, Italy. giorgirossi@asplazio.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Giorgi Rossi
authors.forename: Jessica
authors.initials: J
authors.lastname: Mantovani
authors.forename: Eliana
authors.initials: E
authors.lastname: Ferroni
authors.forename: Antonio
authors.initials: A
authors.lastname: Forcina
authors.forename: Elena
authors.initials: E
authors.lastname: Stanghellini
authors.forename: Filippo
authors.initials: F
authors.lastname: Curtale
authors.forename: Piero
authors.initials: P
authors.lastname: Borgia
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D017714:Community-Acquired Infections / Q000453:epidemiology / Q000382:microbiology; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology; D018563:Disease Notification; D006801:Humans; D015994:Incidence; D007223:Infant; D007558:Italy / Q000453:epidemiology; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000209:etiology; D008875:Middle Aged; D011159:Population Surveillance; D055815:Young Adult