title: Chiral N-phosphonyl imine chemistry: asymmetric synthesis of alpha-alkyl beta-amino ketones by reacting phosphonyl imines with ketone-derived enolates.
abstract: A series of new chiral syn-alpha-branched beta-amino ketones has been synthesized by reacting chiral phosphonyl imines with ketone-derived enolates. The N-protection group on imine auxiliary was found to be crucial to the asymmetric induction. The absolute stereochemistry has been unambiguously determined by converting a product to a known sample.
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79401-1061, USA.
authors.forename: Teng
authors.initials: T
authors.lastname: Ai
authors.forename: Jianlin
authors.initials: J
authors.lastname: Han
authors.forename: Zhong-Xiu
authors.initials: ZX
authors.lastname: Chen
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D007097:Imines; D007659:Ketones