title: Hemophilia and cancer: a new challenge for hemophilia centers.
abstract: The improved life expectancy of hemophilia patients due to the advances in hemophilia care and factor replacement therapy has permitted to hemophiliacs to reach an older age. As a consequence, age-related diseases, such as cardiovascular disorders and cancer, have been increasingly recognized in such patients. In particular, the management of cancer in people with inherited hemorrhagic disorders represents a new challenge for physicians working in hemophilia centers. The few published literature data document that there is a close relationship between hemophilia and neoplasia. Indeed, the congenital bleeding tendency may influence the cancer in different ways, by interfering with its clinical presentation, diagnosis and treatment. These aspects, along with the epidemiology of cancer in hemophiliacs will be discussed in this review.
authors.affiliation: Immunohematology and Transfusion Center - Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy. massimo.franchini@azosp.vr.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.forename: Giovanni
authors.initials: G
authors.lastname: Targher
authors.forename: Marco
authors.initials: M
authors.lastname: Zaffanello
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Salvagno
authors.forename: Gianna Franca
authors.initials: GF
authors.lastname: Rivolta
authors.forename: Caterina Di
authors.initials: CD
authors.lastname: Perna
authors.forename: Annarita
authors.initials: A
authors.lastname: Tagliaferri
mesh_terms: D000328:Adult; D017677:Age Distribution; D015897:Comorbidity; D004359:Drug Therapy, Combination; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D006782:Hospitals, Special; D006801:Humans; D015994:Incidence; D008136:Longevity; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis