Anticoagulants and pregnancy: when are they safe?
Prescribing anticoagulants to pregnant women can be difficult and stressful. Fortunately, low-molecular-weight heparins (LMWHs) and unfractionated heparin are quite safe and efficacious when properly selected, dosed, and monitored. Maternal and fetal concerns must be considered at all times, with a careful assessment of the risks and benefits of anticoagulant therapy in each patient. Further research should help to clarify who should receive thromboprophylaxis, how to prevent adverse pregnancy outcomes in women with various thrombophilias, and how best to treat pregnant women who have a prosthetic heart valve.
Gibson
Paul S
PS
Department of Medicine and Department of Obstetrics and Gynaecology, University of Calgary, Alberta, Canada. gibsonp@ucalgary.ca
Powrie
Raymond
R
D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D018570:Risk Assessment; D020246:Venous Thrombosis / Q000188:drug therapy*
D000925:Anticoagulants