title: Corticotrophin-Releasing Factor Antagonist [alpha helical CRF(9-41)] Blocks Central Noradrenaline-lnduced ACTH Secretion.
abstract: Plasma ACTH increased after an intra-third ventricular administration of noradrenaline (NA). An iv corticotrophin-releasing factor (CRF) antagonist [alpha-helical CRF(9-41)] injection did not affect ACTH secretion by itself, whereas it significantly reduced NA-induced ACTH secretion. These results suggest that NA centrally stimulated ACTH secretion and that endogenous CRF is involved in this ACTH secretion.
authors.affiliation: Third Department of Internal Medicine, Okayama University Medical School, 2-5-1, Shikata-cho, Okayama 700, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takao
authors.forename: K
authors.initials: K
authors.lastname: Hashimoto
authors.forename: R
authors.initials: R
authors.lastname: Hirasawa
authors.forename: S
authors.initials: S
authors.lastname: Makino
authors.forename: M
authors.initials: M
authors.lastname: Sugawara
authors.forename: K
authors.initials: K
authors.lastname: Murakami
authors.forename: Z
authors.initials: Z
authors.lastname: Ota