Appearance of skin lesions in cattle populations vaccinated against lumpy skin disease: statutory challenge.
The ultimate goal of a vaccine is to protect vaccinated animals against re-exposure to the same pathogen and provide sterile immunity. However, a cutaneous clinical manifestation appeared, following re-exposure of cattle that had been vaccinated with the RM65 strain, to LSDV infection during an epidemic in 2006-2007. Four thousand six hundred and seven vaccinated cows entered the study after being re-exposed to LSDV infection. Of them, 513 (11%) presented lumps, and there was a marked difference between the proportions of dairy and feedlot animals that were affected: 146 out of 3517 and 367 out of 1090 (6.6 and 33.7%, respectively). This data suggests that the potency of the vaccine need to be re-assessed for beef cattle.
Brenner
J
J
Department of Virology, Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel. yakovb@moag.gov.il
Bellaiche
M
M
Gross
E
E
Elad
D
D
Oved
Z
Z
Haimovitz
M
M
Wasserman
A
A
Friedgut
O
O
Stram
Y
Y
Bumbarov
V
V
Yadin
H
H
D000818:Animals; D002417:Cattle; D005260:Female; D016679:Genome, Viral; D007557:Israel; D008166:Lumpy Skin Disease / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008167:Lumpy skin disease virus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D012867:Skin / Q000276:immunology / Q000821:virology; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects*
D014613:Vaccines, Attenuated; D014765:Viral Vaccines