Silver-mediated fluorination of functionalized aryl stannanes.
We report a regiospecific silver-mediated fluorination of aryl stannanes. The presented reaction can afford complex fluoroarenes from readily available phenols in three steps. The operational simplicity and the broad substrate scope of the fluorination should render this reaction a useful tool for the synthesis of milligram to gram quantities of functionalized aryl fluorides. Silver-mediated oxidative transformations of aryl nucleophiles that proceed via bimetallic redox processes are a new avenue to develop carbon-heteroatom bond formations.
Furuya
Takeru
T
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts, USA.
Strom
Alexandra E
AE
Ritter
Tobias
T
D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D017971:Tin Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D001555:Benzene Derivatives; D006845:Hydrocarbons, Fluorinated; D010636:Phenols; D017971:Tin Compounds; C031525:stannane; D012834:Silver