title: Airway humidification with a heated wire humidifier during high-frequency ventilation using Babylog 8000 plus in neonates.
abstract: OBJECTIVE
  Little data are available on airway humidity during high-frequency ventilation (HFV). Our purpose is to evaluate the airway humidification during HFV.
  
  
  METHODS
  We examined the airway humidification and temperature in a neonatal HFV system using Babylog 8000 plus. The absolute humidity (AH), relative humidity (RH), and temperature at different sites and under different HFV conditions were compared with those during conventional intermittent positive pressure ventilation (IPPV).
  
  
  RESULTS
  The mean AH and RH at the patient end of the respiratory circuit under 37 degrees C in the humidification chamber (HC) during HFV were less than 35 mg/L and 65%, respectively, while those during IPPV were 42.3 mg/L and 96.8%, respectively. The humidification at the outlet of the HC was similar results. Moreover, during HFV an increase in the bias-flow of ventilator led to a further decrease in the humidity at the patient end of respiratory circuit and the outlet of HC. It was necessary to set the temperature in the HC at >39 degrees C to maintain adequate humidity at the HC and the patient end of respiratory circuit during HFV. An increase in the incubator temperature led to an increase in the temperature at the patient end of the respiratory circuit. The temperature at the patient end of the respiratory circuit was about 39-40 degrees C when the incubator temperature was 35-37 degrees C.
  
  
  CONCLUSIONS
  The airway humidification at the patient end of respiratory circuit and the outlet of HC in HFV were poorer than those in IPPV. However, the adequacy of humidification and safety in HFV remain to be demonstrated in clinical practice.
authors.affiliation: The Center for Maternity and Infant Care, Asahikawa Medical College, Midorigaoka-higashi, Asahikawa, Hokkaido, Japan. nagaya5p@asahikawa-med.ac.jp
authors.forename: Ken
authors.initials: K
authors.lastname: Nagaya
authors.forename: Toshio
authors.initials: T
authors.lastname: Okamoto
authors.forename: Eiki
authors.initials: E
authors.lastname: Nakamura
authors.forename: Tokitsugi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Kenji
authors.initials: K
authors.lastname: Fujieda
mesh_terms: D004867:Equipment Design; D006612:High-Frequency Ventilation / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D006813:Humidity; D007231:Infant, Newborn; D015931:Intensive Care, Neonatal / Q000379:methods*; D007385:Intermittent Positive-Pressure Ventilation / Q000295:instrumentation / Q000379:methods*; D008954:Models, Biological; D013696:Temperature