title: Multifunctional nanoparticles for prostate cancer therapy.
abstract: Multifunctional nanoparticles promise significantly better treatment for prostate cancer. This review begins with a molecular and physiological overview of prostate cancer, including current treatments in various stages of disease development. Emerging nanoparticle technology in chemotherapy, hyperthermia therapy and gene therapy will be discussed. We highlight novel advances in nanoparticle technology for prostate cancer and indicate future challenges in the rational design of multifunctional nanoparticles, such as understanding tumor characteristics and the activation of the complement system.
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anaesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Carolina
authors.initials: C
authors.lastname: Salvador-Morales
authors.forename: Weiwei
authors.initials: W
authors.lastname: Gao
authors.forename: Pooja
authors.initials: P
authors.lastname: Ghatalia
authors.forename: Farhan
authors.initials: F
authors.lastname: Murshed
authors.forename: Wataru
authors.initials: W
authors.lastname: Aizu
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods; D008297:Male; D053758:Nanoparticles; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000503:physiopathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents