Association between cytokines and cerebral MRI changes in the aging brain.
The association between cytokines (IL-1 beta, sIL-4R, IL-6, IL-8, IL-10, IL-12, TNF-alpha) and subcortical white matter lesions, cortical atrophy and lacunar infarctions of the aging brain was investigated among 268 elderly community participants. Single pro- and anti-inflammatory cytokines were neither associated with WML nor with atrophy and lacunar infarction. An association between atrophy and the chemokine-cytokine factor (containing sIL-4R, IL-6, IL-8) remained significant after adjustment for age, gender, education, depressive symptoms, diabetes mellitus, cardiovascular diseases (stroke, TIA, myocardial infarction, myocardial insufficiency, arrhythmic heart), hypertension, body-mass index, smoking status and aggregation inhibitors as opposed to single cytokines. Atrophy of the parietal, temporal and occipital lobes was associated with the same cytokine-chemokine factor for both the whole sample or restricted to those without history of stroke/TIA. The results indicate that a combination of chemokine-cytokines rather than single cytokines may contribute to inflammatory processes associated with cortical atrophy in the aging brain.
Baune
Bernhard T
BT
Department of Psychiatry, School of Medicine, James Cook University, Queensland, Australia. Bernhard.Baune@jcu.edu.au
Ponath
Gerald
G
Rothermundt
Matthias
M
Roesler
Andreas
A
Berger
Klaus
K
D017677:Age Distribution; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001284:Atrophy / Q000175:diagnosis / Q000453:epidemiology; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D020520:Brain Infarction / Q000175:diagnosis / Q000453:epidemiology; D015897:Comorbidity; D003430:Cross-Sectional Studies; D016207:Cytokines / Q000097:blood*; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000453:epidemiology; D007378:Interleukins / Q000097:blood; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology; D016017:Odds Ratio; D025341:Principal Component Analysis; D017678:Sex Distribution; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology
D016207:Cytokines; D007378:Interleukins