title: Seoul virus and hantavirus disease, Shenyang, People's Republic of China.
abstract: An outbreak of hemorrhagic fever with renal syndrome (HFRS) occurred among students in Shenyang Pharmaceutical University in 2006. We conducted a study to characterize etiologic agents of the outbreaks and clarify the origin of hantaviruses causing infections in humans and laboratory animals. Immunoglobulin (Ig) M or IgG antibodies against Seoul virus (SEOV) were detected in the serum samples of all 8 patients. IgG antibodies against hantavirus were also identified in laboratory rats, which were used by these students for their scientific research. Phylogenetic analysis showed that partial small segment sequences recovered from humans, laboratory rats, and local wild rats belonged to SEOV. Hantavirus sequences recovered from humans and laboratory rats clustered within 1 of 3 lineages of SEOV circulating among local wild rats in Shenyang. These results suggest that the HFRS outbreak in Shenyang was caused by SEOV that was circulating among local wild rats and had also infected the laboratory rats.
authors.affiliation: Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. yongzhenzhang@sohu.com
authors.forename: Yong-Zhen
authors.initials: YZ
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Dong
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.forename: Hai-Ping
authors.initials: HP
authors.lastname: Xiong
authors.forename: Guang-Jie
authors.initials: GJ
authors.lastname: Yan
authors.forename: Na
authors.initials: N
authors.lastname: Gao
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Jiang
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Li
authors.forename: Lu-Ping
authors.initials: LP
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Zou
authors.forename: Alexander
authors.initials: A
authors.lastname: Plyusnin
mesh_terms: D000328:Adult; D000818:Animals; D000830:Animals, Laboratory / Q000821:virology; D000835:Animals, Wild / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051189:Murinae / Q000821:virology; D010802:Phylogeny; D051381:Rats; D017208:Rats, Wistar; D012376:Rodent Diseases / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D029263:Seoul virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D013334:Students; D014495:Universities; D055815:Young Adult; D015047:Zoonoses / Q000453:epidemiology / Q000635:transmission / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M