title: Use of fertility drugs and risk of ovarian cancer: Danish Population Based Cohort Study.
abstract: OBJECTIVE
  To examine the effects of fertility drugs on overall risk of ovarian cancer using data from a large cohort of infertile women.
  
  
  METHODS
  Population based cohort study.
  
  
  METHODS
  Danish hospitals and private fertility clinics.
  
  
  METHODS
  54,362 women with infertility problems referred to all Danish fertility clinics during 1963-98. The median age at first evaluation of infertility was 30 years (range 16-55 years), and the median age at the end of follow-up was 47 (range 18-81) years. Included in the analysis were 156 women with invasive epithelial ovarian cancer (cases) and 1241 subcohort members identified in the cohort during follow-up in 2006.
  
  
  METHODS
  Effect of four groups of fertility drugs (gonadotrophins, clomifene citrate, human chorionic gonadotrophin, and gonadotrophin releasing hormone) on overall risk of ovarian cancer after adjustment for potential confounding factors.
  
  
  RESULTS
  Analyses within cohort showed no overall increased risk of ovarian cancer after any use of gonadotrophins (rate ratio 0.83, 95% confidence interval 0.50 to 1.37), clomifene (1.14, 0.79 to 1.64), human chorionic gonadotrophin (0.89, 0.62 to 1.29), or gonadotrophin releasing hormone (0.80, 0.42 to 1.51). Furthermore, no associations were found between all four groups of fertility drugs and number of cycles of use, length of follow-up, or parity.
  
  
  CONCLUSIONS
  No convincing association was found between use of fertility drugs and risk of ovarian cancer.
authors.affiliation: Danish Cancer Society, Institute of Cancer Epidemiology, Strandboulevarden 49, DK-2100, Copenhagen, Denmark. allan@cancer.dk
authors.forename: Allan
authors.initials: A
authors.lastname: Jensen
authors.forename: Heidi
authors.initials: H
authors.lastname: Sharif
authors.forename: Kirsten
authors.initials: K
authors.lastname: Frederiksen
authors.forename: Susanne Krüger
authors.initials: SK
authors.lastname: Kjaer
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005299:Fertility Agents / Q000009:adverse effects*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000453:epidemiology; D008423:Maternal Age; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D010298:Parity; D011247:Pregnancy; D012307:Risk Factors; D055815:Young Adult
chemical_list: D005299:Fertility Agents