title: Analysis of the association of IL1B (C+3954T) and IL1RN (intron 2) polymorphisms with dental implant loss in a Brazilian population.
abstract: BACKGROUND
  Although dental implants have a high success rate, failures occur, in spite of adequate clinical conditions. Together with the observation that multiple implant losses occur in certain groups of individuals (clusterization phenomenon), this suggests that host response may influence implant failure. Little is known about the influence of genetic susceptibility on implant loss. Interleukin (IL)-1 beta and IL-1 ra are believed to play a key role in the immune-inflammatory response, and polymorphisms IL1B (C+3954T) and IL1RN (intron 2) are shown to alter the coding proteins expression.
  
  
  OBJECTIVE
  The aim of this study was to investigate the association between dental implant loss and polymorphisms IL1B (+3954) and IL1RN (intron 2).
  
  
  METHODS
  The study population (n=266) was divided into Test group (T)- 90 subjects with implant loss, and Control group (C)- 176 subjects without any implant failure. Genotyping was performed by PCR-RFLP.
  
  
  RESULTS
  The number of present teeth was observed to influence implant loss. No differences in genotype and allele frequencies between C and T were found for IL1B (+3954) and IL1RN (intron 2) polymorphisms. However, the analysis of the whole study population (control and test groups) showed that genotype 2/2 was significantly more frequent in individuals with multiple implant losses (n=35) than in individuals that lost up to a single implant (n=231) (OR: 3.07, IC: 1.13-8.34, P=0.027).
  
  
  CONCLUSIONS
  It was observed that number of teeth and edentulism were associated with implant loss. Genotype 2/2 of IL1RN polymorphism was significantly more frequent in patients who presented multiple losses, which suggests that the clusterization phenomenon has a genetic basis.
authors.affiliation: Graduate Program at Centro de Ensino Superior dos Campos Gerais (CESCAGE), Ponta Grossa, PR, Brazil.
authors.forename: Claudia Cristina
authors.initials: CC
authors.lastname: Montes
authors.forename: Fabiano
authors.initials: F
authors.lastname: Alvim-Pereira
authors.forename: Bruno Borges
authors.initials: BB
authors.lastname: de Castilhos
authors.forename: Marcos Luciano Lopes
authors.initials: ML
authors.lastname: Sakurai
authors.forename: Marcia
authors.initials: M
authors.lastname: Olandoski
authors.forename: Paula Cristina
authors.initials: PC
authors.lastname: Trevilatto
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001938:Brazil; D016022:Case-Control Studies; D003596:Cytosine; D015921:Dental Implants; D019232:Dental Restoration Failure; D003817:Dentition; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000235:genetics*; D053583:Interleukin-1beta / Q000235:genetics*; D007438:Introns / Q000235:genetics*; D007575:Jaw, Edentulous / Q000145:classification; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D012907:Smoking; D013941:Thymine
chemical_list: D015921:Dental Implants; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D053583:Interleukin-1beta; D003596:Cytosine; D013941:Thymine