title: Efalizumab for severe palmo-plantar psoriasis: an open-label pilot trial in five patients.
abstract: BACKGROUND
  Palmo-plantar psoriasis (PPP) is a disabling condition that significantly impairs quality of life. PPP tends to be resistant to conventional therapies and may last for several years. Topical treatments are usually ineffective. Systemic therapy with oral retinoids and psoralen plus ultraviolet A is frequently required, although it rarely leads to remission.
  
  
  METHODS
  We conducted an open-label, pilot study to evaluate treatment of PPP with efalizumab, an anti-CD11a monoclonal antibody approved for the treatment of chronic, refractory moderate to severe plaque psoriasis in adults.
  
  
  METHODS
  Five patients with severe PPP received efalizumab treatment for 24 weeks.
  
  
  RESULTS
  All five patients responded favourably by week 12 and showed further improvement at week 24 of uninterrupted therapy. Mean physician-assessed severity scores and patient-reported outcome scores improved almost 75% after 12 weeks and 90% after 24 weeks. At week 32, three patients maintained the response seen at week 24, while two patients suspended efalizumab.
  
  
  CONCLUSIONS
  Efalizumab therapy was well tolerated and effective in five patients with severe PPP, allowing a significant improvement in quality of life.
authors.affiliation: Department of Dermatology, Galliera Hospital, Genoa, Italy.
authors.forename: A M G
authors.initials: AM
authors.lastname: Brunasso
authors.forename: C
authors.initials: C
authors.lastname: Salvini
authors.forename: C
authors.initials: C
authors.lastname: Massone
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D002464:Cell Migration Inhibition; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011565:Psoriasis / Q000188:drug therapy*
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; C472181:efalizumab