title: Demographic and clinical characteristics associated with glomerular filtration rates in living kidney donors.
abstract: Due to the shortage of organs, living donor acceptance criteria are becoming less stringent. An accurate determination of the glomerular filtration rate (GFR) is critical in the evaluation of living kidney donors and a value exceeding 80 ml/min per 1.73 m(2) is usually considered suitable. To improve strategies for kidney donor screening, an understanding of factors that affect GFR is needed. Here we studied the relationships between donor GFR measured by (125)I-iothalamate clearances (mGFR) and age, gender, race, and decade of care in living kidney donors evaluated at the Cleveland Clinic from 1972 to 2005. We report the normal reference ranges for 1057 prospective donors (56% female, 11% African American). Females had slightly higher mGFR than males after adjustment for body surface area, but there were no differences due to race. The lower limit of normal for donors (5th percentile) was less than 80 ml/min per 1.73 m(2) for females over age 45 and for males over age 40. We found a significant doubling in the rate of GFR decline in donors over age 45 as compared to younger donors. The age of the donors and body mass index increased over time, but their mGFR, adjusted for body surface area, significantly declined by 1.49+/-0.61 ml/min per 1.73 m(2) per decade of testing. Our study shows that age and gender are important factors determining normal GFR in living kidney donors.
authors.affiliation: Department of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland,Ohio 44195, USA. poggioe@ccf.org
authors.forename: Emilio D
authors.initials: ED
authors.lastname: Poggio
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Rule
authors.forename: Roberto
authors.initials: R
authors.lastname: Tanchanco
authors.forename: Susana
authors.initials: S
authors.lastname: Arrigain
authors.forename: Robert S
authors.initials: RS
authors.lastname: Butler
authors.forename: Titte
authors.initials: T
authors.lastname: Srinivas
authors.forename: Brian R
authors.initials: BR
authors.lastname: Stephany
authors.forename: Kathryn H
authors.initials: KH
authors.lastname: Meyer
authors.forename: Saul
authors.initials: S
authors.lastname: Nurko
authors.forename: Richard A
authors.initials: RA
authors.lastname: Fatica
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Shoskes
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Krishnamurthi
authors.forename: David A
authors.initials: DA
authors.lastname: Goldfarb
authors.forename: Inderbir
authors.initials: I
authors.lastname: Gill
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Schreiber
mesh_terms: D000328:Adult; D001741:Black or African American; D000367:Age Factors; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation / Q000592:standards*; D019520:Living Donors / Q000600:supply & distribution; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors; D044465:White People