title: Synchronous diagnosis of multiple tumours in a postmenopausal woman.
abstract: We report an unusual case of a postmenopausal woman that was diagnosed with multiple tumours derived from different embryogenic tissues. She presented with postmenopausal vaginal bleeding. Clinical examination revealed a large pelvic mass, tender on palpation. Serum CA-125 level was elevated at 8,985 kU/l (normal range 0-35). A CT scan showed a malignant-appearing right ovarian mass with a peritoneal nodule, small amount of free fluid in the pelvis and evidence of a colonic intussusception. The patient underwent total abdominal hysterectomy, bilateral salpingo-ophorectomy, partial omentectomy and right hemicolectomy with side-to-side anastomosis. Histopathology showed a Grade 3 endometrial adenocarcinoma. Both ovaries were completely replaced by partially necrotic poorly differentiated endometrioid adenocarcinoma. Small deposits of metastatic adenocarcinoma were seen within the omentum. Sections from the retroperitoneal mass showed a low-grade liposarcoma. A large polypoid tumour within the right colon was a tubulo-villous adenoma.
authors.affiliation: Department of Obstetrics and Gynaecology, Ipswich Hospital, Ipswich, IP4 5PD, UK. nikosburbos@hotmail.com
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Burbos
authors.forename: Ilias
authors.initials: I
authors.lastname: Giarenis
authors.forename: Joe
authors.initials: J
authors.lastname: Ostrowski
authors.forename: Ray
authors.initials: R
authors.lastname: Lonsdale
authors.forename: Joaquin J
authors.initials: JJ
authors.lastname: Nieto
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis*; D000236:Adenoma / Q000175:diagnosis*; D000368:Aged; D003110:Colonic Neoplasms / Q000175:diagnosis*; D005260:Female; D005833:Genital Neoplasms, Female / Q000175:diagnosis*; D006801:Humans; D008080:Liposarcoma / Q000175:diagnosis*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D017698:Postmenopause; D012186:Retroperitoneal Neoplasms / Q000175:diagnosis*