Pertussis outbreak in primary and secondary schools in Ludwigslust, Germany demonstrating the role of waning immunity.
A pertussis outbreak primarily affecting school-age children in Ludwigslust, Germany, was investigated in 2006 to estimate attack rates and relative risk of pertussis according to time since last vaccination, after a complete primary course. Results suggested waning immunity beginning approximately 5 years after the last dose of pertussis vaccination. Most cases could have been prevented by earlier booster vaccination.
Sin
Muna Abu
MA
Field Epidemiology Training Program, Robert Koch Institute, Berlin, Germany.
Zenke
Rosemarie
R
Rönckendorf
Rita
R
Littmann
Martina
M
Jorgensen
Pernille
P
Hellenbrand
Wiebke
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004196:Disease Outbreaks; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007109:Immunity / Q000276:immunology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010567:Pertussis Vaccine / Q000276:immunology; D012307:Risk Factors; D012574:Schools; D014611:Vaccination / Q000706:statistics & numerical data; D014917:Whooping Cough / Q000453:epidemiology* / Q000276:immunology* / Q000382:microbiology / Q000635:transmission; D055815:Young Adult
D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine