title: Studying the interactions of drugs and hydrophobic model membranes using contact angle goniometry.
abstract: This study demonstrates a method where contact angle goniometry combined with surface tension measurements is used to assess the interactions of drugs with the hydrophobic core of a biological membrane. To this end, self-assembled monolayers (SAMs) of two alkanethiol and one thiolipid on Au(111) surfaces are used as model membranes and their interaction with six beta-blockers is studied. The Gibbs equation and the Langmuir adsorption isotherm are used to determine the partition coefficients for the adsorption of the drugs, which are compared to the octanol-water partition coefficients as well as the liposome-water partition coefficients. The ability of the different SAMs to serve as model membranes in partitioning of drugs is discussed.
authors.affiliation: Helsinki University of Technology, Laboratory of Physical Chemistry and Electrochemistry, PO Box 6100, FI-02015 TKK, Finland.
authors.forename: Marjukka
authors.initials: M
authors.lastname: Ikonen
authors.forename: Lasse
authors.initials: L
authors.lastname: Murtomäki
authors.forename: Kyösti
authors.initials: K
authors.lastname: Kontturi
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008567:Membranes, Artificial; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial