title: Appearance of skin lesions in cattle populations vaccinated against lumpy skin disease: statutory challenge.
abstract: The ultimate goal of a vaccine is to protect vaccinated animals against re-exposure to the same pathogen and provide sterile immunity. However, a cutaneous clinical manifestation appeared, following re-exposure of cattle that had been vaccinated with the RM65 strain, to LSDV infection during an epidemic in 2006-2007. Four thousand six hundred and seven vaccinated cows entered the study after being re-exposed to LSDV infection. Of them, 513 (11%) presented lumps, and there was a marked difference between the proportions of dairy and feedlot animals that were affected: 146 out of 3517 and 367 out of 1090 (6.6 and 33.7%, respectively). This data suggests that the potency of the vaccine need to be re-assessed for beef cattle.
authors.affiliation: Department of Virology, Kimron Veterinary Institute, P.O. Box 12, Bet Dagan 50250, Israel. yakovb@moag.gov.il
authors.forename: J
authors.initials: J
authors.lastname: Brenner
authors.forename: M
authors.initials: M
authors.lastname: Bellaiche
authors.forename: E
authors.initials: E
authors.lastname: Gross
authors.forename: D
authors.initials: D
authors.lastname: Elad
authors.forename: Z
authors.initials: Z
authors.lastname: Oved
authors.forename: M
authors.initials: M
authors.lastname: Haimovitz
authors.forename: A
authors.initials: A
authors.lastname: Wasserman
authors.forename: O
authors.initials: O
authors.lastname: Friedgut
authors.forename: Y
authors.initials: Y
authors.lastname: Stram
authors.forename: V
authors.initials: V
authors.lastname: Bumbarov
authors.forename: H
authors.initials: H
authors.lastname: Yadin
mesh_terms: D000818:Animals; D002417:Cattle; D005260:Female; D016679:Genome, Viral; D007557:Israel; D008166:Lumpy Skin Disease / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008167:Lumpy skin disease virus / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D008297:Male; D012867:Skin / Q000276:immunology / Q000821:virology; D014613:Vaccines, Attenuated / Q000009:adverse effects; D014765:Viral Vaccines / Q000009:adverse effects*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines