title: blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures.
abstract: CTX-M-producing Escherichia coli isolates from three Croatian hospitals were analyzed. All bla(CTX-M-15) genes and one bla(CTX-M-3a) gene resided in widely spread ISEcp1 transposition modules, but other bla(CTX-M-3a) genes were in a new configuration with two IS26 copies, indicating a new event of gene mobilization from a Kluyvera ascorbata genome. The study confirmed the role of the E. coli ST131 clonal group with IncFII-type plasmids in the spread of bla(CTX-M-15) and of IncL/M pCTX-M3-type plasmids in the dissemination of bla(CTX-M-3a).
authors.affiliation: National Medicines Institute, Warsaw, Poland.
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Literacka
authors.forename: Branka
authors.initials: B
authors.lastname: Bedenic
authors.forename: Anna
authors.initials: A
authors.lastname: Baraniak
authors.forename: Janusz
authors.initials: J
authors.lastname: Fiett
authors.forename: Marija
authors.initials: M
authors.lastname: Tonkic
authors.forename: Ines
authors.initials: I
authors.lastname: Jajic-Bencic
authors.forename: Marek
authors.initials: M
authors.lastname: Gniadkowski
mesh_terms: D001483:Base Sequence; D004251:DNA Transposable Elements; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; C473109:beta-lactamase CTX-M-15; C417271:beta-lactamase CTX-M-3; D001618:beta-Lactamases