Antimicrobial and immunomodulatory attributes of statins: relevance in solid-organ transplant recipients.
Statins are increasingly being used to treat solid-organ transplant recipients for posttransplantation metabolic complications. In addition to improving dyslipidemia, statins also have manifold non-lipid-lowering effects. With regard to sepsis or infection, these agents modify the inflammatory cascades by pleiotropic actions at multiple levels and exhibit activities against opportunistic bacteria, fungi, and viruses that can cause serious infections in solid-organ transplant recipients. They also have synergistic interactions with antimicrobial agents. Statins with antimicrobial and immunomodulatory attributes might improve morbidity and mortality attributable to sepsis or infection in solid-organ transplant recipients.
Sun
Hsin-Yun
HY
Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Singh
Nina
N
D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D018797:Cell Cycle Proteins / Q000494:pharmacology* / Q000627:therapeutic use; D005658:Fungi / Q000187:drug effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D020648:Peptide Elongation Factor 1; D018805:Sepsis / Q000188:drug therapy / Q000517:prevention & control; D014180:Transplantation; D014780:Viruses / Q000187:drug effects
D000890:Anti-Infective Agents; D018797:Cell Cycle Proteins; C503234:EEF1A2 protein, human; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007155:Immunologic Factors; D020648:Peptide Elongation Factor 1