Modelling the early phases of bone regeneration around an endosseous oral implant.
The objective of this study was to see whether a mathematical model of fracture healing was able to mimic bone formation around an unloaded screw-shaped titanium implant as it is well-believed that both processes exhibit many biological similarities. This model describes the spatio-temporal evolution of cellular activities, ranging from mesenchymal stem cell migration, proliferation, differentiation to bone formation, which are initiated and regulated by the growth factors present at the peri-implant site. For the simulations, a finite volume code was used and adequate initial and boundary conditions were applied. Two sets of analyses have been performed, in which either initial and boundary condition or model parameter values were changed with respect to the fracture healing model parameter values. For a number of combinations, the spatio-temporal evolution of bone density was well-predicted. However reducing cell proliferation rate and increasing osteoblast differentiation and osteogenic growth factor synthesis rates, the simulation results were in agreement with the experimental data.
Amor
N
N
Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, Katholieke Universiteit Leuven (K.U.L.), Leuven, Belgium. nadia.amor@mech.kuleuven.be
Geris
L
L
Vander Sloten
J
J
Van Oosterwyck
H
H
D000818:Animals; D001698:Biomedical Engineering; D015519:Bone Density / Q000502:physiology; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001863:Bone Screws; D002454:Cell Differentiation; D002465:Cell Movement; D003198:Computer Simulation; D017102:Fracture Healing / Q000502:physiology; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D051379:Mice; D008954:Models, Biological; D016348:Osseointegration / Q000502:physiology*; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D019736:Prostheses and Implants; D014025:Titanium
D019485:Bone Morphogenetic Proteins; D014025:Titanium