title: "Signet-ring" cell invasive lobular carcinoma of the breast - accidental finding associated with intraductal papilloma: a case report.
abstract: BACKGROUND
  A 57-year old woman had only unilateral milky dischardge of the right breast. Clinical and mammography findings were normal.
  
  
  METHODS
  Cytological diagnosis of intraductal papilloma was established which was galactographically confitmed and patient underwent to surgery. Ductulolobular segmentectomy was made. Histopathologically beside intraductal papilloma numerous single dispread malignant "signet ring" cells in the fibrous retromammilary stroma were found. Imunohistochemically findings were: cytokeratin 8 positive, ER H-score 80, PR H-score 50, HER-2/neu negative. Diagnosis of "signet ring" cell lobular invasive carcinoma was made, followed by mastectomy, axillary limphadectomy and contra lateral breast biopsy.
  
  
  CONCLUSIONS
  Residual tumor were found only in the breast tissue, while axillary lymph nodes and contra lateral breast biopsy were negative. Patient underwent to oncology therapy.
authors.affiliation: Department of Pathology and Forensic Medicine, Clinical Hospital Osijek, Osijek, Croatia. valery@net.hr.
authors.forename: Valerija
authors.initials: V
authors.lastname: Blazicević
authors.forename: Blazenka
authors.initials: B
authors.lastname: Staklenac
authors.forename: Jozo
authors.initials: J
authors.lastname: Kristek
authors.forename: Marija
authors.initials: M
authors.lastname: Pajtler
authors.forename: Zlatko
authors.initials: Z
authors.lastname: Krajinović
authors.forename: Damir
authors.initials: D
authors.lastname: Stimac
authors.forename: Zdravko
authors.initials: Z
authors.lastname: Ivezić
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Kotromanović
authors.forename: Ilijan
authors.initials: I
authors.lastname: Tomas
authors.forename: Marta
authors.initials: M
authors.lastname: Biljan