New directions in host modulation for the management of periodontal disease.
BACKGROUND
New strategies for periodontal disease management have been emerging as more is learned about the role of the host response. Our increasing understanding of inflammation and its resolution has opened the door to the study of new periodontal treatment strategies. This commentary examines periodontal disease in light of a new understanding of the role of inflammation in disease expression, thus setting the stage for the development of new prevention and treatment strategies of a widespread disease.


METHODS
We examined current publications and focused on articles relating to anti-inflammatory and pro-resolution mechanisms in periodontal disease.


RESULTS
Recent research has examined the inflammatory and resolution cascade in greater detail while looking at endogenous and exogenous mediators that can be utilized to achieve therapeutic end-points. The possible introduction of "resolution indices" for drug testing warrants a new look at pharmacologic agents that might have been overlooked for their beneficial effects in periodontal disease treatment.


CONCLUSIONS
The emerging awareness of inflammation and its control in periodontal disease management underscores the importance of exploring inflammatory pathways and mediators, thus exploring new ways to control inflammation. This direction of research promises a new era in drug discovery and therapeutics for periodontal disease treatment.
Bhatavadekar
Neel B
NB
Department of Periodontology, University of Texas Health Science Center, Houston, TX, USA. Neel.Bhatavadekar@uth.tmc.edu
Williams
Ray C
RC
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D018836:Inflammation Mediators; D010518:Periodontitis / Q000188:drug therapy* / Q000276:immunology*
D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators