title: Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
abstract: Drug delivery, magnetic resonance and fluorescence imaging, magnetic manipulation, and cell targeting are simultaneously possible using a multifunctional mesoporous silica nanoparticle. Superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation. Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts. The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
authors.forename: Monty
authors.initials: M
authors.lastname: Liong
authors.forename: Jie
authors.initials: J
authors.lastname: Lu
authors.forename: Michael
authors.initials: M
authors.lastname: Kovochich
authors.forename: Tian
authors.initials: T
authors.lastname: Xia
authors.forename: Stefan G
authors.initials: SG
authors.lastname: Ruehm
authors.forename: Andre E
authors.initials: AE
authors.lastname: Nel
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Tamanoi
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Zink
mesh_terms: D003287:Contrast Media; D003460:Crystallization / Q000639:trends; D016503:Drug Delivery Systems / Q000639:trends*; D007089:Image Enhancement / Q000379:methods*; D007287:Inorganic Chemicals / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D036103:Nanotechnology / Q000639:trends*; D010316:Particle Size
chemical_list: D003287:Contrast Media; D007287:Inorganic Chemicals