title: Alopecia in congenital hidrotic ectodermal dysplasia responding to treatment with a combination of topical minoxidil and tretinoin.
abstract: Clouston's syndrome is an ectodermal dysplasia characterized by dystrophic nails, alopecia, and palmoplantar hyperkeratosis. Alopecia is due to decrease in number and degree of maturation of the hair follicles. Tretinoin is a mitogen by itself and also enhances the absorption of minoxidil which acts by enlarging the miniaturized hair follicles. We report a case of alopecia in Clouston's syndrome who responded to treatment with topical minoxidil and tretinoin.
authors.affiliation: Department of Dermatology, LTM Medical College and General Hospital, Sion, Mumbai, India. shubha_melkote@yahoo.com
authors.forename: Shubha
authors.initials: S
authors.lastname: Melkote
authors.forename: Rachita S
authors.initials: RS
authors.lastname: Dhurat
authors.forename: Anjali
authors.initials: A
authors.lastname: Palav
authors.forename: Hemangi R
authors.initials: HR
authors.lastname: Jerajani
mesh_terms: D000287:Administration, Topical; D000505:Alopecia / Q000188:drug therapy* / Q000209:etiology*; D002648:Child; D003879:Dermatologic Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004476:Ectodermal Dysplasia / Q000150:complications*; D006197:Hair / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008297:Male; D008914:Minoxidil / Q000008:administration & dosage*; D014212:Tretinoin / Q000008:administration & dosage*
chemical_list: D003879:Dermatologic Agents; D014212:Tretinoin; D008914:Minoxidil