title: Implementation of quantitative perfusion imaging using pulsed arterial spin labeling at ultra-high field.
abstract: This study compares the implementation of the STAR and FAIR pulsed arterial spin labeling (PASL) schemes to form quantitative perfusion maps at ultra-high field, 7 Tesla (T), and high field, 3 T. Phantom experiments were performed to compare the inversion efficiency and profile of the labeling pulses at 7 T and 3 T and to optimize in-plane saturation techniques. The perfusion weighted (PW) signal was measured at a range of postlabeling delay times and quantitative perfusion maps were calculated on a voxel-by-voxel basis. An increase in PW signal was found with field strength, and together with the increased signal-to-noise ratio, this led to improved image signal-to-noise and quality of fit of perfusion maps at 7 T.
authors.affiliation: Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, United Kingdom.
authors.forename: A G
authors.initials: AG
authors.lastname: Gardener
authors.forename: P A
authors.initials: PA
authors.lastname: Gowland
authors.forename: S T
authors.initials: ST
authors.lastname: Francis
mesh_terms: D001158:Arteries / Q000033:anatomy & histology* / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods*; D012680:Sensitivity and Specificity; D013113:Spin Labels; D055815:Young Adult
chemical_list: D013113:Spin Labels