title: [Study on stability of curcumine, demethoxycurcumin and bisdemethoxycurcumin].
abstract: OBJECTIVE
  To investigate the stability of curcumin, demethoxycurcumin and bisdemethoxycurcumin in different buffer solution.
  
  
  METHODS
  To determine concentration of curcumin by HPLC when added curcumin, demethoxycurcumin and bisdemethoxycurcumin into the buffer solution the equation of degradation was established.
  
  
  RESULTS
  The sequence of stability are bisdemethoxycurcumin > or = demethoxycurcumin > or =curcumin at the same condition.
  
  
  CONCLUSIONS
  The demethoxycurcumin can stabilize curcumin more strong than the others. The demethoxycurcumin is a nature stabilizing agent for curcumin.
authors.affiliation: Pharmaceutical Department, North China Coal Medical University, Tangshan 063000, China. tsyxhg@163.com
authors.forename: Gang
authors.initials: G
authors.lastname: Han
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Cui
authors.forename: Rui
authors.initials: R
authors.lastname: Bi
authors.forename: Lin-lin
authors.initials: LL
authors.lastname: Zhao
authors.forename: Wei-guo
authors.initials: WG
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry*; D036381:Diarylheptanoids; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration
chemical_list: D036381:Diarylheptanoids; C034786:bisdemethoxycurcumin; D003474:Curcumin; C050229:demethoxycurcumin