Benzene risk estimation using radiation equivalent coefficients.
We estimated benzene risk using a novel framework of risk assessment that employed the measurement of radiation dose equivalents to benzene metabolites and a PBPK model. The highest risks for 1 microg/m(3) and 3.2 mg/m(3) life time exposure of benzene estimated with a linear regression were 5.4 x 10(-7) and 1.3 x 10(-3), respectively. Even though these estimates were based on in vitro chromosome aberration test data, they were about one-sixth to one-fourteenth that from other studies and represent a fairly good estimate by using radiation equivalent coefficient as an "internal standard."
Nakayama
Aki
A
Kyoto University, Graduate School of Engineering, Urban and Environmental Engineering, Kyoto Daigaku Katsura 4, Nishikyo, Kyoto, 615-8540, Japan. nakayama@risk.env.kyoto-u.ac.jp
Isono
Tomomi
T
Kikuchi
Takuro
T
Ohnishi
Iichiro
I
Igarashi
Junichiro
J
Yoneda
Minoru
M
Morisawa
Shinsuke
S
D000328:Adult; D001554:Benzene / Q000009:adverse effects* / Q000378:metabolism / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects / Q000528:radiation effects; D003198:Computer Simulation; D005260:Female; D006801:Humans; D019570:Inhalation Exposure; D007700:Kinetics; D007938:Leukemia / Q000139:chemically induced; D015394:Molecular Structure; D011853:Radiobiology / Q000379:methods*; D018570:Risk Assessment / Q000379:methods*
D001554:Benzene