[The melatonin influence on the proxidant/antioxidant balance in rats during a cold exposure with subsequent rewarming].
We aimed to study the melatonin influence on the prooxidant-antioxidant balance in rats during a cold exposure with subsequent rewarming. The cold exposure lasted 120 min. in the box with a water temperature of 19 degrees C; rewarming was performed for the next 120 min. with a mean rate of 0.6 degrees C during 10 min. Melatonin was administered intraperitoneally 30 min before the cold exposure in the dose of 1 ml as a bolus (0.1, 1, or 10 mg/kg) or periodically (1 mg/kg/day, 4 days). We measured the lipid peroxidation products (conjugated dienes and Schiff bases) and antioxidant defense factors (alpha-tocopherol, catalase). Melatonin lowered the tissue lipid peroxidation activity and enhanced the better antioxidant defense may affect the severity of disorders developing during the post-hypothennic state.
Zinchuk
V V
VV
Glutkin
S V
SV
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002374:Catalase / Q000097:blood*; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D016877:Oxidants / Q000097:blood; D051381:Rats; D022722:Thermogenesis / Q000187:drug effects*; D024502:alpha-Tocopherol / Q000097:blood*
D000975:Antioxidants; D016877:Oxidants; D002374:Catalase; D024502:alpha-Tocopherol; D008550:Melatonin