title: Cortisol exerts site-, context- and dose-dependent effects on agonistic responding in hamsters.
abstract: Abstract Site-, context- and dose-dependent actions of intrahypothalamic cortisol administration on the agonistic behaviors of adult male golden hamsters (n = 128 dyads) were examined. When cortisol-treated animals were tested in paired encounters with aggressive cholesterol-treated opponents, chronic (>/= 24 h) cortisol treatment (1 mm implants) induced significant (P < 0.05) submission in three medial hypothalamic areas (anterior hypothalamic area > medial preoptic area > ventromedial hypothalamus), but aggression in the paraventricular nucleus or third ventricle. In contrast, chronic cortisol treatment in the anterior hypothalamic area resulted in high levels of aggression during paired encounters with submissive opponents, and during territorial aggression tests with juvenile male intruders. Acute (>/= 20 min) cortisol treatment in the anterior hypothalamic area (100 nl injections) induced significant submission after 10(-2) M, but significant aggression after 10(-6) M microinjections in paired encounters with aggressive vehicle-injected opponents. These findings suggest glucocorticoid-sensitive mechanisms within the anterior hypothalamus modulate aggressive responding during intrasexual social encounters.
authors.affiliation: Department of Physiology, University of Massachusetts Medical Center, Worcester, Massachusetts, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Hayden-Hixson
authors.forename: C F
authors.initials: CF
authors.lastname: Ferris