title: Invasive hydatidiform mole: immunohistochemical labelling of inhibin/activin subunits, Ki67, p53 and glycodelin A in a rare case.
abstract: Invasive trophoblastic mole is an extremely rare condition. Its early recognition is essential since it can transform into an invasive type of tumour. Immunohistochemistry was performed with monoclonal antibodies against inhibin-alpha, -betaA and -betaB, Ki67, p53 and glycodelin A in a rare case of accidentally diagnosed invasive trophoblastic mole. There was labelling of the inhibin/activin subunits, Ki67 and p53, while glycodelin A showed minimal immunopositivity. Therefore, since the pathological diagnosis of an invasive mole is difficult, the immunohistochemical detection of inhibin/activin subunits, Ki67, p53 and glycodelin A might be additional useful tumour markers.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Rostock, Rostock, Germany.
authors.forename: Josef
authors.initials: J
authors.lastname: Makovitzky
authors.forename: Anngret
authors.initials: A
authors.lastname: Radtke
authors.forename: Naim
authors.initials: N
authors.lastname: Shabani
authors.forename: Klaus
authors.initials: K
authors.lastname: Friese
authors.forename: Bernd
authors.initials: B
authors.lastname: Gerber
authors.forename: Ioannis
authors.initials: I
authors.lastname: Mylonas
mesh_terms: D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods*; D028322:Inhibin-beta Subunits / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D000071816:Glycodelin; D006023:Glycoproteins; D019394:Ki-67 Antigen; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D016159:Tumor Suppressor Protein p53; D028322:Inhibin-beta Subunits