[Cerebral sinovenous thrombosis and acquired antithrombin, protein C and S deficiency during chemotherapy in a young man: report of a case].
L-asparaginase is commonly used in the chemotherapy regimens for acute lymphoblastic leukaemia. Its use is associated with thrombotic complications in 1 to 14 % of the cases. The pathogenesis of this complication is still unclear. However, the decrease of antithrombin seems to play an important role. We report a case of a 17-year old man with a acute lymphoblastic leukaemia, who developed a cerebral sinovenous thrombosis due to an acquired deficiency of antithrombin and protein C and S following L-asparaginase chemotherapy. We discuss the use of prophylactic supplements of antithrombin and the value of screening of thrombophilia based on the recent medical literature.
Munoz
V Terrones
VT
Service d'Oncologie, C.H.U. de Charleroi, Site André Vésale, Montigny-le-Tilleul. vterrone@ulb.ac.be
Triffet
A
A
Cauchie
P
P
Brohée
D
D
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020152:Antithrombin III Deficiency / Q000235:genetics*; D000991:Antithrombins / Q000172:deficiency* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects*; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000235:genetics*; D020151:Protein C Deficiency / Q000235:genetics*; D018455:Protein S Deficiency / Q000235:genetics*; D019851:Thrombophilia / Q000175:diagnosis
D000970:Antineoplastic Agents; D000991:Antithrombins; D001215:Asparaginase