Bicyclononane aldehydes and antiproliferative constituents from Amomum tsao-ko.
A racemic mixture of a new bicyclononane aldehyde, (1 RS,5 SR,6 RS)-5-hydroxybicyclo[4.3.0]non-2-ene-2-carbaldehyde (1) was isolated from the fruits of Amomum tsao-ko, together with 12 known compounds (2-13). The structure of 1 was determined on the basis of extensive spectroscopic analysis, including 1D and 2D NMR data. The antiproliferative activity of compounds 1-13 was assessed in the murine neuroblastoma cell line N2a.
Yang
Xinzhou
X
Institute of Pharmaceutical Biology, University of Basel, Basel, Switzerland.
Küenzi
Peter
P
Plitzko
Inken
I
Potterat
Olivier
O
Hamburger
Matthias
M
D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035801:Amomum / Q000737:chemistry*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D005638:Fruit; D051379:Mice; D015394:Molecular Structure; D009447:Neuroblastoma; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C543382:(1RS,5SR,6RS)-5-hydroxybicyclo(4.3.0)non-2-ene-2-carbaldehyde; D000447:Aldehydes; D000972:Antineoplastic Agents, Phytogenic; D001643:Bridged Bicyclo Compounds; D010936:Plant Extracts