The effect of parecoxib and indometacin on tendon-to-bone healing in a bone tunnel: an experimental study in rats.
Conventional non-steroidal anti-inflammatory drugs (NSAIDs) and newer specific cyclo-oxygenase-2 (cox-2) inhibitors are commonly used in musculoskeletal trauma and orthopaedic surgery to reduce the inflammatory response and pain. These drugs have been reported to impair bone metabolism. In reconstruction of the anterior cruciate ligament the hamstring tendons are mainly used as the graft of choice, and a prerequisite for good results is healing of the tendons in the bone tunnel. Many of these patients are routinely given NSAIDs or cox-2 inhibitors, although no studies have elucidated the effects of these drugs on tendon healing in the bone tunnel. In our study 60 female Wistar rats were randomly allocated into three groups of 20. One received parecoxib, one indometacin and one acted as a control. In all the rats the tendo-Achillis was released proximally from the calf muscles. It was then pulled through a drill hole in the distal tibia and sutured anteriorly. The rats were given parecoxib, indometacin or saline intraperitoneally twice daily for seven days. After 14 days the tendon/bone-tunnel interface was subjected to mechanical testing. Significantly lower maximum pull-out strength (p < 0.001), energy absorption (p < 0.001) and stiffness (p = 0.035) were found in rats given parecoxib and indometacin compared with the control group, most pronounced with parecoxib.
Dimmen
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Orthopaedic Centre, Ullevaal University Hospital and Faculty of Medicine, University of Oslo, N-0407 Oslo, Norway. sidimmen@online.no
Nordsletten
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Engebretsen
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Steen
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Madsen
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D000818:Animals; D016118:Anterior Cruciate Ligament / Q000187:drug effects* / Q000601:surgery; D001696:Biomechanical Phenomena; D015519:Bone Density / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D013710:Tendons / Q000187:drug effects*; D014945:Wound Healing / Q000187:drug effects*
D016861:Cyclooxygenase Inhibitors; D007555:Isoxazoles; C409945:parecoxib; D007213:Indomethacin