title: A rapid approach to the synthesis of highly functionalized tetrahydroisoquinolines.
abstract: A palladium-catalyzed domino ortho-alkylation/alkenylation forming up to three new C-C bonds furnishes functionalized tetrahydroisoquinolines in up to 87% yield. Extension to the formation of tetrahydrobenzoazepines and tetrahydroisoquinolinones is presented.
authors.affiliation: Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Canada M5S3H6.
authors.forename: Praew
authors.initials: P
authors.lastname: Thansandote
authors.forename: Christina
authors.initials: C
authors.lastname: Gouliaras
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Turcotte-Savard
authors.forename: Mark
authors.initials: M
authors.lastname: Lautens
mesh_terms: D001381:Azepines / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D007700:Kinetics; D010165:Palladium / Q000737:chemistry; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001381:Azepines; D044005:Tetrahydroisoquinolines; D010165:Palladium