[Principle energy substrate changing as a technique of myocardium protection against ischemic damage in experimental mechanic cardiac contusion].
By changing the principal energy substrate, trimetasidine has reduced severity of ischemic myocardial damage as shown by greater integrity of membrane structures, improvement of contractile and rhythmic functions, central hemodynamics and lethality early after experimental myocardial contusion.
Korpacheva
O V
OV
Dolgikh
V T
VT
D000818:Animals; D003288:Contusions / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control*; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D014292:Trimetazidine / Q000494:pharmacology*; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D014292:Trimetazidine