title: Multi-slice CT contrast-enhanced presentations of advanced gastric cancer: associations with histo-differentiation and expression of p53 and P-glycoprotein.
abstract: BACKGROUND
  This study aimed to investigate multi-slice CT contrast-enhanced presentation of gastric cancer and its correlation with histo-differentiation and p53 and P-glycoprotein (P-gp) expression.
  
  
  METHODS
  Sixty-six patients with gastric cancer in the present study underwent a multi-slice CT preoperative routine and dual-phase contrast-enhanced examination of the upper abdomen; postoperative specimens were used to determine histo-differentiation and the expression of p53 and P-gp. The correlation of multi-slice CT contrast-enhanced presentation with histo-differentiation and expression of p53 and P-gp was analyzed.
  
  
  RESULTS
  The dual-phase contrast-enhanced ratio (CER) was not correlated with the histo-differentiation of gastric cancer (P > 0.05). Positive expression of p53 and P-gp was significantly higher in the cases of layered or heterogeneous enhancement than in the cases of homogenous enhancement (P < 0.05). Positive expression of p53 was also correlated with the arterial phase CER, tumor size and lymph node metastasis (P < 0.05), but not with infiltration thickness of the gastric wall, nor was it correlated with the portal phase CER (P > 0.05). Positive expression of P-gp was only correlated with the portal phase CER (P = 0.005).
  
  
  CONCLUSIONS
  Differently enhanced pattern and CER of the arterial and portal phase in gastric cancer correlate with its different histo-differentiation and expression of p53 and P-gp respectively. In addition, tumor size and lymph node metastasis of gastric cancer relate to the expression of p53.
authors.affiliation: Department of Radiology, Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing, Jiangsu, China. yinxindao1965152@sohu.com
authors.forename: Xin-dao
authors.initials: XD
authors.lastname: Yin
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Wang
authors.forename: Ling-quan
authors.initials: LQ
authors.lastname: Lu
authors.forename: Li-wei
authors.initials: LW
authors.lastname: Wang
authors.forename: Guang-hui
authors.initials: GH
authors.lastname: Xie
authors.forename: Qian-zhi
authors.initials: QZ
authors.lastname: Wu
authors.forename: Shu-zhi
authors.initials: SZ
authors.lastname: Wang
authors.forename: Jian-ping
authors.initials: JP
authors.lastname: Gu
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism* / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D016159:Tumor Suppressor Protein p53