TgI4 lipase: a big fat target for cell-cycle entry.
In a recent issue of Molecular Cell, Kurat et al. (2009) find that when quiescent yeast re-enter the cell cycle, the cell-cycle cyclin-dependent kinase phosphorylates and activates the lipase TgI4, liquidating fat and providing fatty acids for cell-cycle entry.
Futcher
Bruce
B
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA. bfutcher@ms.cc.sunysb.edu
D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D008049:Lipase / Q000378:metabolism*; D010766:Phosphorylation; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*
D018797:Cell Cycle Proteins; D005656:Fungal Proteins; D029701:Saccharomyces cerevisiae Proteins; D018844:Cyclin-Dependent Kinases; D008049:Lipase; C506904:Tgl4 protein, S cerevisiae