Cycloadditions of 1,1-disubstituted benzocyclobutenes obtained by C(sp3)-H activation.
An efficient synthesis of polycyclic molecules has been performed by a sequence involving palladium-catalyzed C-H activation and [4 + 2] cycloaddition. The intermediate benzocyclobutenes underwent a microwave-enhanced electrocyclic ring-opening/cycloaddition process with complete torquoselectivity and diastereoselectivity.
Chaumontet
Manon
M
Institut de Chimie des Substances Naturelles, CNRS UPR2301, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Retailleau
Pascal
P
Baudoin
Olivier
O