title: [Effects of H2-blockers on alcohol dehydrogenase (ADH) activity].
abstract: First-pass metabolism (FPM) of alcohol is demonstrated by lower blood alcohol concentrations after oral than intravenous administration of the same dose. FPM occurs predominantly in the stomach and has been attributed to class IV of alcohol dehydrogenase (ADH) isoenzyme localizated in the gastric mucosa. A number of factors that influence on gastric ADH activity and thereby modulate FPM have been identified. These include age, sex, ethnicity, concentrations and amounts of alcohol consumed and drugs. Several H2-receptor antagonists, including cimetidine and ranitidine, inhibit gastric ADH activity and reduce FPM, resulting in higher blood alcohol concentrations after H2-blockers administration.
authors.affiliation: Uniwersytet Medyczny w Białymstoku, Zakład Diagnostyki Biochemicznej. zdb@umwb.edu.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Jelski
authors.forename: Karolina
authors.initials: K
authors.lastname: Orywal
authors.forename: Maciej
authors.initials: M
authors.lastname: Szmitkowski
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D000431:Ethanol / Q000097:blood*; D005753:Gastric Mucosa / Q000378:metabolism; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D006801:Humans; D011899:Ranitidine / Q000494:pharmacology; D013270:Stomach / Q000201:enzymology
chemical_list: D006635:Histamine H2 Antagonists; D000431:Ethanol; D002927:Cimetidine; D011899:Ranitidine; D000426:Alcohol Dehydrogenase