Disease confined within the ovary and smaller amount of ascites are good prognostic factors for survival of patients with squamous cell carcinoma arising from mature cystic teratoma of the ovary: a case series in Korea and review of the published reports.
OBJECTIVE
To identify clinical prognostic factors for survival of patients with squamous cell carcinoma (SqCC) arising from mature cystic teratoma (MCT) of the ovary with review of the published reports.


METHODS
Clinical data of 55 patients with SqCC arising from MCT of the ovary who were reported in the Korean Journal of Obstetrics and Gynecology and the Korean Journal of Gynecologic Oncology and Colposcopy between 1992 and 2006 were reviewed. Clinical factors were analyzed to identify their association with disease-free survival and overall survival (OS), which were evaluated using the Kaplan-Meier analysis with the log-rank test. Clinical prognostic factors were identified using Cox's proportional hazard analysis.


RESULTS
Patients with disease confined within the ovary (n = 31) or ascites <500 mL (n = 15) had the benefit of a higher mean OS than those with advanced disease (n = 8) (116 vs 21 months, P = 0.004) and ascites > or =500 mL (n = 7) (106 vs 8 months, P = 0.005), respectively. Disease confined within the ovary and ascites <500 mL were good prognostic factors by univariate but not multivariate Cox's proportional hazard analyses (HR = 0.123 and 0.139, 95% confidence interval = 0.022-0.670 and 0.027-0.722, respectively).


CONCLUSIONS
Disease confined within the ovary and a smaller amount of ascites may be good prognostic factors for the OS of patients with SqCC arising from MCT of the ovary.
Kim
Hee Seung
HS
Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
Kim
Jae Weon
JW
Chung
Hyun Hoon
HH
Park
Noh-Hyun
NH
Song
Yong-Sang
YS
Kang
Soon-Beom
SB
D001201:Ascites / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D013724:Teratoma / Q000473:pathology*