Reelin, radial fibers and cortical evolution: insights from comparative analysis of the mammalian and avian telencephalon.
The mammalian cerebral cortex has a remarkable laminated structure, which is derived from the pallium, the dorsal part of the embryonic telencephalon. Recent studies indicate that the pallium is developed as a homologous structure in all vertebrate species. However, the cellular and molecular mechanism for making architectural diversity of the pallium is not fully understood. Here we introduce recent progress in comparative analysis of pallial development, and our data on the role of Reelin protein in the developing avian pallium. These experimental approaches to pallial development in non-mammalian species will provide a new insight into evolution of the cerebral cortex.
Nomura
Tadashi
T
Department of Cell and Molecular Biology, Karolinska Institute, 171-77 Sweden. Tadashi.Nomura@ki.se
Hattori
Mitsuharu
M
Osumi
Noriko
N
D000818:Animals; D005075:Biological Evolution; D001717:Birds / Q000033:anatomy & histology* / Q000196:embryology; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism / Q000502:physiology*; D002540:Cerebral Cortex / Q000033:anatomy & histology* / Q000196:embryology; D016326:Extracellular Matrix Proteins / Q000378:metabolism / Q000502:physiology*; D008322:Mammals / Q000033:anatomy & histology* / Q000196:embryology; D009419:Nerve Tissue Proteins / Q000378:metabolism / Q000502:physiology*; D000091042:Reelin Protein; D012697:Serine Endopeptidases / Q000378:metabolism / Q000502:physiology*; D013687:Telencephalon / Q000033:anatomy & histology* / Q000196:embryology
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D000091042:Reelin Protein; D012697:Serine Endopeptidases