title: Comparison of spectral- and time-domain optical coherence tomography for retinal thickness measurements in healthy and diseased eyes.
abstract: OBJECTIVE
  To compare retinal thickness (RT) measurements obtained by spectral-domain optical coherence tomography (SD-OCT) and time-domain OCT (TD-OCT) in eyes with and without posterior segment disease diagnoses.
  
  
  METHODS
  Retrospective, observational chart review.
  
  
  METHODS
  Scans of 184 healthy and diseased eyes from 106 patients were included in the study. Pair-wise comparisons of RT measurements from SD-OCT machines from 2 different manufacturers and TD-OCT were performed for all scans and with eyes stratified by disease diagnosis.
  
  
  RESULTS
  Foveal thickness measurements obtained from both SD-OCT machines were greater than those measured by TD-OCT, by 51.0 +/- 23.8 microm and 72.5 +/- 30.4 microm, respectively. The foveal thickness difference between the 2 SD-OCT models was 24.3 +/- 19.1 microm. Foveal thickness differences varied by disease diagnosis.
  
  
  CONCLUSIONS
  RT measurements obtained by SD-OCT are consistently greater than those obtained by TD-OCT. RT measurement differences may vary by disease diagnosis or by SD-OCT model. Consideration of these measurement differences is essential when OCT-determined RT measurement data are used in clinical settings.
authors.affiliation: Duke Eye Center, Durham, North Carolina 27701, USA.
authors.forename: Ian C
authors.initials: IC
authors.lastname: Han
authors.forename: Glenn J
authors.initials: GJ
authors.lastname: Jaffe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012160:Retina / Q000033:anatomy & histology* / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D055815:Young Adult