title: A new entry of copper-catalyzed four-component reaction: facile access to alpha-aryl beta-hydroxy imidates.
abstract: Alpha-aryl beta-hydroxy imidates are efficiently obtained by the four-component reaction of ethyl glyoxylates, aryl acetylenes, sulfonyl azides, and alcohols using a copper catalyst. The developed procedure is characterized by high selectivity, mild reaction conditions, a wide substrate scope, and an excellent functional group tolerance. Facile transformations of the obtained sulfonylimidate moiety to other carbonyl groups such as sulfonamides or esters were also demonstrated.
authors.affiliation: Department of Chemistry and School of Molecular Science (BK21), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea.
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Yoo
authors.forename: Sae Hume
authors.initials: SH
authors.lastname: Park
authors.forename: Sang Hyup
authors.initials: SH
authors.lastname: Lee
authors.forename: Sukbok
authors.initials: S
authors.lastname: Chang
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D007096:Imidoesters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000438:Alcohols; D000480:Alkynes; D007096:Imidoesters; D013449:Sulfonamides; D003300:Copper