CoCAS: a ChIP-on-chip analysis suite.
BACKGROUND
High-density tiling microarrays are increasingly used in combination with ChIP assays to study transcriptional regulation. To ease the analysis of the large amounts of data generated by this approach, we have developed ChIP-on-chip Analysis Suite (CoCAS), a standalone software suite which implements optimized ChIP-on-chip data normalization, improved peak detection, as well as quality control reports. Our software allows dye swap, replicate correlation and connects easily with genome browsers and other peak detection algorithms. CoCAS can readily be used on the latest generation of Agilent high-density arrays. Also, the implemented peak detection methods are suitable for other datasets, including ChIP-Seq output.


BACKGROUND
The software is available for download along with a sample dataset at http://www.ciml.univ-mrs.fr/software/ferrier.htm.


BACKGROUND
Supplementary data are available at Bioinformatics online.
Benoukraf
Touati
T
Centre d'Immunologie de Marseille-Luminy, CNRS, UMR6102, Inserm, U631, Université de la Méditerranée and Inserm, U928, TAGC, Marseille, France.
Cauchy
Pierre
P
Fenouil
Romain
R
Jeanniard
Adrien
A
Koch
Frederic
F
Jaeger
Sébastien
S
Thieffry
Denis
D
Imbert
Jean
J
Andrau
Jean-Christophe
JC
Spicuglia
Salvatore
S
Ferrier
Pierre
P
D047369:Chromatin Immunoprecipitation / Q000379:methods*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D012984:Software