[Fine mapping of a pure paroxysmal kinesigenic dyskinesia family].
OBJECTIVE
To fine map the gene responsible for pure paroxysmal kinesigenic dyskinesia in a Chinese family.


METHODS
Six additional markers flanking the tightly linked markers were chosen in the candidate region resulting from a whole genome-wide scanning and tested by parameter and nonparameter analysis using Linkage and Genehunter softwares to fine map the candidate region.


RESULTS
Evidence for linkage of the pure paroxysmal kinesigenic dyskinesia to chromosome 3 was further confirmed. A maximum two-lod score of 2.82 at theta=0 was obtained with D3S3669. Critical recombinants place the PKD gene between D3S1314 and D3S1265.


CONCLUSIONS
A new locus of pure paroxysmal kinesigenic dyskinesia (PKD) is localized within a 10.2 cM interval on 3q28-29, between markers D3S1314 and D3S1265.
Liu
Ding
D
Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008 PR China.
Li
Guo-liang
GL
Chen
Chan-juan
CJ
Zhou
Jin-xia
JX
Zhang
Bei
B
Wu
Zhi-guo
ZG
Xiao
Bo
B
D000293:Adolescent; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002819:Chorea / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D015894:Genome, Human / Q000235:genetics; D023281:Genomics; D006239:Haplotypes; D006801:Humans; D008297:Male; D010375:Pedigree
D005819:Genetic Markers