[The denydroepiandrosterone sulfate thyroid activation through the mu-opioid receptors under cold influences].
Denydroepiandrosterone-sulfate (DHEAS) effects on total thyroxine (tT4), total triiodothyronine (tT3), and free thyroxine (tT4) levels were studied in male rats under single or repeated (for 19 days, 1 hr a day) cold influences, as well as participation of mu-opioid receptor effects in DHEAS (30 mg/kg). It was shown that the increased tT4 and tT3 levels under repeated cold influences were more obvious after DHEAS injections. The opioid antagonist naltrexone in the dose 0.1 mg/kg reversed the DHEAS effect. These data suggest involvement of mu-opioid receptors in that thyroid activation. Under a single cold influence DHEAS did not produce the effects at tT4, or tT3 levels, and the action of mu-opioid receptor blocker in this situation was not manifested. The fT4 levels were obviously increased both under repeated or single cold influences, but the DHEAS and naltrexone actions were absent.
Obut
T A
TA
Saryg
S K
SK
Grigor'eva
T A
TA
Dement'eva
T Iu
TIu
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003080:Cold Temperature; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D013961:Thyroid Gland / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*
D000276:Adjuvants, Immunologic; D009292:Narcotic Antagonists; D017450:Receptors, Opioid, mu; D014284:Triiodothyronine; D003687:Dehydroepiandrosterone; D009271:Naltrexone; D013974:Thyroxine