TiO(2)-modified macroporous silica foams for advanced enrichment of multi-phosphorylated peptides.
Enriching peptides: Novel TiO(2)-modified macroporous materials (Ti-MOSF, see figure) have been synthesized with high surface area, large pore volume, and functional surfaces that are rich in coordinatively unsaturated Ti(IV) species, which can be applied in the specific extraction of phosphopeptides and which show a preferential capture of multi-phosphorylated peptides with low detection limits and high selectivity.
Wan
Jingjing
J
Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and Institute of Biomedical Sciences, Fudan University, Shanghai 200433, PR China.
Qian
Kun
K
Qiao
Liang
L
Wang
Yunhua
Y
Kong
Jilie
J
Yang
Pengyuan
P
Liu
Baohong
B
Yu
Chengzhong
C
D015394:Molecular Structure; D010748:Phosphopeptides / Q000737:chemistry*; D010766:Phosphorylation; D040901:Proteomics / Q000379:methods; D012822:Silicon Dioxide / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D014025:Titanium / Q000737:chemistry*
D010748:Phosphopeptides; C009495:titanium dioxide; D012822:Silicon Dioxide; D014025:Titanium