title: Haemostatic markers are associated with measures of vascular disease in adults with hypertension.
abstract: Haemostatic markers have been implicated in the development and progression of vascular disease. We investigated the associations of several haemostatic markers (fibrinogen, D-dimer, FV, FVII, FVIII, von Willebrand factor (vWF) and antithrombin III) with two quantitative measures of vascular disease in adults with hypertension. Participants included 1051 African Americans (65+/-9 years, 72% women) and 894 non-Hispanic whites (61+/-9 years, 55% women) belonging to hypertensive sibships. Phenotypes of vascular disease included the ankle-brachial index (ABI), a measure of peripheral arterial disease, and urinary albumin/creatinine ratio (UACR), a surrogate of glomerular endothelial function. Generalized estimating equations were used to assess whether plasma levels of haemostatic markers were associated with measures of arteriosclerosis, after adjustment for conventional risk factors and medication (statin, aspirin and oestrogen) use. Higher fibrinogen and D-dimer were significantly associated with lower ABI in African Americans (P<0.001 and 0.004 respectively) and in non-Hispanic whites (P<0.001 and 0.010 respectively). Higher fibrinogen (P<0.001), D-dimer (P=0.003), FVIII (P<0.001) and vWF (P<0.001) were significantly associated with higher UACR in African Americans, whereas, in non-Hispanic whites, higher fibrinogen (P=0.020) and FVII (P=0.006) were significantly associated with higher UACR. Our findings indicate that in adults with essential hypertension, several markers in the haemostatic pathway are independently associated with ABI and UACR, two measures of vascular disease..
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: M
authors.initials: M
authors.lastname: Khaleghi
authors.forename: L A
authors.initials: LA
authors.lastname: Singletary
authors.forename: V
authors.initials: V
authors.lastname: Kondragunta
authors.forename: K R
authors.initials: KR
authors.lastname: Bailey
authors.forename: S T
authors.initials: ST
authors.lastname: Turner
authors.forename: T H
authors.initials: TH
authors.lastname: Mosley
authors.forename: I J
authors.initials: IJ
authors.lastname: Kullo
mesh_terms: D001741:Black or African American; D000368:Aged; D000419:Albuminuria / Q000652:urine; D055109:Ankle Brachial Index; D000990:Antithrombin III / Q000378:metabolism; D001161:Arteriosclerosis / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D015415:Biomarkers / Q000097:blood*; D003404:Creatinine / Q000652:urine; D005165:Factor V / Q000378:metabolism; D005167:Factor VII / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D044465:White People; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; C036309:fibrin fragment D; D014841:von Willebrand Factor; D000990:Antithrombin III; D005165:Factor V; D005167:Factor VII; D005169:Factor VIII; D005340:Fibrinogen; D003404:Creatinine