[Pulmonary involvement in the course of cytomegalovirus infection in an immunocompetent adult].
BACKGROUND
Cytomegalovirus (CMV) infection in the immunocompetent is generally silent or it may present as a mononucleosis like syndrome but, rarely, it can lead to symptomatic manifestations.


METHODS
An immunocompetent and previously healthy 43- year-old woman presented with fever, dyspnoea, liver cell necrosis and a mononucleosis syndrome. The CT scan showed diffuse ground-glass opacity. BAL and blood cultures were sterile. Urinary antigens (Legionella pneumophila, Streptococcus pneumoniae) and serology for atypical respiratory pathogens (Mycoplasma pneumoniae and Chlamydia sp.) were negative. A diagnosis of CMV pneumonia was established on serology (presence of anti-CMV IgM) and PCR detection of viral DNA in the serum. Without antiviral therapy, there was a favourable clinical outcome 1 week later and 1 month later the CT scan was normal.


CONCLUSIONS
CMV infection can lead, exceptionally. to a hypoxic pneumonia in the immunocompetent host. Antiviral therapy should not be prescribed systematically.
Margery
J
J
Service de Pneumologie, HIA Legouest, Metz, France. j.magery@free.fr
Lefebvre
N
N
Dot
J-M
JM
Gervaise
A
A
Andriamanantena
D
D
Dieudonné
M
M
Girodeau
A
A
D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007121:Immunocompetence; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011024:Pneumonia, Viral / Q000000981:diagnostic imaging / Q000209:etiology*; D016133:Polymerase Chain Reaction; D013902:Radiography, Thoracic; D013997:Time Factors
D007074:Immunoglobulin G; D007075:Immunoglobulin M