title: Physico-chemical and structural characterization of diacerhein.
abstract: The physico-chemical and structural characterization of diacerhein, an anthraquinone with antiinflammatory activity, employed in the symptomatic treatment of inflammatory osteoarthritis, is reported. The combined use of FT-IR, DSC, X-ray powder and single-crystal diffraction has provided a valuable tool to fully characterize the title compound. The X-ray diffraction study has revealed the existence of hydrogen-bond assisted tight packing of the quasi-planar molecules in the solid. The collected results are intended to implement the information required for the compilation of drug master files.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Firenze, Sesto Fiorentino (Florence), Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bambagiotti-Alberti
authors.forename: Gianluca
authors.initials: G
authors.lastname: Bartolucci
authors.forename: Bruno
authors.initials: B
authors.lastname: Bruni
authors.forename: Silvia A
authors.initials: SA
authors.lastname: Coran
authors.forename: Massimo
authors.initials: M
authors.lastname: Di Vaira
mesh_terms: D000880:Anthraquinones / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D003460:Crystallization; D018360:Crystallography, X-Ray; D004055:Differential Thermal Analysis; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D012015:Reference Standards; D017550:Spectroscopy, Fourier Transform Infrared; D013607:Tablets
chemical_list: D000880:Anthraquinones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013607:Tablets; C025292:diacerein