title: Assist control volume guarantee ventilation during surfactant administration.
abstract: OBJECTIVE
  To measure changes in ventilator parameters in preterm infants receiving surfactant during assist control volume guarantee (AC/VG) ventilation.
  
  
  METHODS
  22 preterm infants (up to 32 weeks' gestation) receiving surfactant for respiratory distress syndrome were enrolled in a prospective study of ventilator parameters during AC/VG ventilation at a tertiary neonatal intensive care unit. Ventilator pressures, flow and tidal volume waveforms were recorded from the Dräger Babylog 8000 plus in real time, and compared to pre-surfactant measurements.
  
  
  RESULTS
  Following surfactant administration, 21 of 22 babies experienced completely obstructed endotracheal gas flow. Peak inflation pressure (PIP) increased by a median (IQR) of 8 (4-10) cm H2O, and took 30-60 min to return to baseline. Inspired oxygen concentration was reduced from a median (IQR) of 39% (26%-44%) to 26% (21%-30%) in the first 5 min. The set maximum PIP (Pmax) limited the delivered PIP such that most babies received tidal volumes less than the target value (V(Ttarget)) immediately following surfactant delivery. Four infants, in a subgroup of 11 infants where Pmax was set to less than 10 cm H2O above baseline PIP, were still receiving <90% of V(Ttarget) 20 min post surfactant.
  
  
  CONCLUSIONS
  When giving surfactant during AC/VG ventilation, complete obstruction is common. PIPs increased and remain elevated for 30-60 min. The Pmax setting may restrict tidal volume delivery.
authors.affiliation: Neonatal Services, The Royal Women's Hospital (RWH), Melbourne, Australia. kevin.wheeler@thewomens.org.au
authors.forename: K I
authors.initials: KI
authors.lastname: Wheeler
authors.forename: P G
authors.initials: PG
authors.lastname: Davis
authors.forename: C O F
authors.initials: CO
authors.lastname: Kamlin
authors.forename: C J
authors.initials: CJ
authors.lastname: Morley
mesh_terms: D001315:Australia; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D015931:Intensive Care, Neonatal; D008297:Male; D011175:Positive-Pressure Respiration / Q000379:methods*; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology / Q000628:therapy*; D013501:Surface-Active Agents / Q000627:therapeutic use*; D013990:Tidal Volume / Q000502:physiology*; D015300:Ventilator Weaning / Q000379:methods
chemical_list: D013501:Surface-Active Agents