title: Tissue microarray assessment of selenoprotein P expression in gastric adenocarcinoma.
abstract: This study investigated selenoprotein P expression, using immunohistochemistry, in gastric adenocarcinoma tissue microarrays constructed from 30 gastric adenocarcinoma specimens and 30 normal gastric tissues (controls). Selenoprotein P expression scores were significantly lower in gastric adenocarcinoma (17/30, 56.7%) than in control tissues (25/30, 83.3%). Selenoprotein P was significantly more likely to be expressed in well-to-moderately differentiated cases (13/17, 76.5%) than in cases with low differentiation (4/13, 30.8%) and there was no significant difference in selenoprotein P expression between tumour node metastasis (TNM) stage I - II (11/19, 57.9%) and TNM stage III (6/11, 54.5%). In conclusion, selenoprotein P expression was low in gastric adenocarcinoma tissues compared with control tissues and was related to the degree of gastric adenocarcinoma differentiation but not to TNM stage.
authors.affiliation: Department of General Surgery, Tangdu Hospital, The Fourth Military Medical University, X'an, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Gong
authors.forename: R
authors.initials: R
authors.lastname: Dong
authors.forename: Q
authors.initials: Q
authors.lastname: Qiao
authors.forename: X-L
authors.initials: XL
authors.lastname: He
authors.forename: Y-K
authors.initials: YK
authors.lastname: Chu
authors.forename: X-L
authors.initials: XL
authors.lastname: Du
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Zang
authors.forename: J
authors.initials: J
authors.lastname: Nan
authors.forename: C
authors.initials: C
authors.lastname: Lin
authors.forename: J-G
authors.initials: JG
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D051149:Selenoprotein P / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D046888:Tissue Array Analysis
chemical_list: D051149:Selenoprotein P