title: Gene therapy for malignant pleural mesothelioma: present and future.
abstract: Malignant pleural mesothelioma is relatively rare in frequency but one of the intractable diseases linked with asbestos exposure. Clinical outcomes with the present treatment modalities are unsatisfactory and no effective prevention method has been reported. Growing numbers of the patients in the Western countries with a long latent period need development of a novel therapeutic strategy. Gene therapy is a candidate for mesothelioma treatment because of its easy accessibility of a vector-mediated gene medicine into the intrapleural cavity. Several preclinical studies demonstrated that the gene medicine produced antitumor effects, suggesting the feasibility in clinical settings. In this article, we review the current status of gene therapy and clinical trials targeting mesothelioma and address possible directions to improve the efficacy.
authors.affiliation: Department of Respirology, Graduate School of Medicine, Chiba University, Chiba 260-8670, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Tada
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Takiguchi
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Hideaki
authors.initials: H
authors.lastname: Shimada
authors.forename: Taro
authors.initials: T
authors.lastname: Ueyama
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakamura
authors.forename: Koichiro
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kuriyama
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Tagawa
mesh_terms: D002986:Clinical Trials as Topic; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D016147:Genes, Tumor Suppressor; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008654:Mesothelioma / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D010997:Pleural Neoplasms / Q000235:genetics / Q000378:metabolism / Q000628:therapy*; D013937:Thymidine Kinase / Q000235:genetics / Q000378:metabolism
chemical_list: D016207:Cytokines; D013937:Thymidine Kinase