Controlled release of matrix metalloproteinase 1 with or without skeletal myoblasts transplantation improves cardiac function of rat hearts with chronic myocardial infarction.
Skeletal myoblast transplantation has been applied clinically for severe ischemic cardiomyopathy. Matrix metalloproteinase 1 (MMP-1) reduces fibrosis and prevents the progress of heart failure. We hypothesized that MMP-1 administration to the infarct area enhances the efficacy of skeletal myoblast transplantation. The controlled release of MMP-1 improved cardiac functions of rats with chronic myocardiac infarction with or without transplantation of skeletal myoblasts. Improvement in cardiac function and small fibrotic area inside the infarcted area were observed compared with those of myoblast transplantation. In conclusion, controlled release of MMP-1 was effective in cardioprotection in postmyocardial infarction although the combination with cell transplantation showed the similar effect.
Lin
Xue
X
Department of Biomaterials, Field of Tissue Engineering, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, Japan.
Tammbara
Keiichi
K
Fu
Michael
M
Yamamoto
Masaya
M
Premaratne
Goditha U
GU
Sakakibara
Yutaka
Y
Marui
Akira
A
Ikeda
Tadashi
T
Komeda
Masashi
M
Tabata
Yasuhiko
Y
D000818:Animals; D006328:Cardiac Catheterization; D002908:Chronic Disease; D004247:DNA / Q000008:administration & dosage; D003692:Delayed-Action Preparations; D005355:Fibrosis; D005455:Fluorescent Antibody Technique; D006334:Heart Function Tests; D006801:Humans; D020781:Matrix Metalloproteinase 1 / Q000008:administration & dosage*; D032448:Myoblasts, Skeletal / Q000637:transplantation*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy*; D009206:Myocardium / Q000473:pathology; D009929:Organ Size; D010957:Plasmids / Q000008:administration & dosage; D051381:Rats; D011917:Rats, Inbred Lew; D014019:Tissue Donors; D014463:Ultrasonography
D003692:Delayed-Action Preparations; D004247:DNA; D020781:Matrix Metalloproteinase 1