title: Two cases of pollen-food allergy syndrome to soy milk diagnosed by skin prick test, specific serum immunoglobulin E and microarray analysis.
abstract: Oral allergy syndrome to soy milk is classified as a phenotype of pollen-food allergy syndrome (PFAS). As causative antigens, Gly m 4 (Bet v 1 homolog, 17 kD) and oleosin (23 kD), have been reported. In this study, we report two cases of PFAS to soy milk. Both cases showed positive reactions to soy milk in skin prick tests (SPT) and to Gly m 4 in specific serum immunoglobulin (Ig)E antibody. When we measured specific serum IgE antibody of soy-related proteins using a new laboratory testing method, microarray analysis, both cases showed a positive reaction for Bet v 1. One case was weakly positive for a soybean protein, beta-conglycinin. Other results for reactivity to soy, peanut, cross-reactive carbohydrate determinants and profilin were negative. Based on these results, we diagnosed the two cases as PFAS to Gly m 4. We also performed protein microarray analysis and found it useful as a screening test for immediate allergy, such as PFAS.
authors.affiliation: Department of Dermatology, Fujita Health University School of Medicine, Aichi, Japan. ayagami@nch.go.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Yagami
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Inaba
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuno
authors.forename: Kayoko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Sigrid
authors.initials: S
authors.lastname: Sjolander
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Saito
authors.forename: Kayoko
authors.initials: K
authors.lastname: Matsunaga
mesh_terms: D000328:Adult; D052179:Antigens, Plant / Q000009:adverse effects / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008565:Membrane Proteins / Q000009:adverse effects / Q000276:immunology; D008875:Middle Aged; D010940:Plant Proteins / Q000009:adverse effects / Q000276:immunology; D040081:Protein Array Analysis; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications* / Q000276:immunology; D012882:Skin Tests; D041942:Soy Milk; D013025:Glycine max / Q000009:adverse effects / Q000276:immunology; D013577:Syndrome
chemical_list: D052179:Antigens, Plant; C530536:Gly m 4 allergen, Glycine max; D008565:Membrane Proteins; D010940:Plant Proteins; C079299:oleosin 24 protein, Glycine max; D007073:Immunoglobulin E