title: A total synthesis of norhalichondrin B.
abstract: Four corners: The syntheses of four key building blocks for the total synthesis of norhalichondrin B (see structure) are described. The assembly of these subunits into the natural product is also reported. Key features of the synthesis are the use of the Achmatowicz oxidation/ionic hydrogenation for the synthesis of pyrans and pyranopyrans, and the application of tandem metathesis for the synthesis of pyranopyrans.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309-0215, USA.
authors.forename: Katrina L
authors.initials: KL
authors.lastname: Jackson
authors.forename: James A
authors.initials: JA
authors.lastname: Henderson
authors.forename: Hajime
authors.initials: H
authors.lastname: Motoyoshi
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Phillips
mesh_terms: D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D006865:Hydrogenation; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005663:Furans; D011714:Pyrans; C526099:norhalichondrin B