[Effects of urinary function and erectile function on the use of mecobalamin after nerve sparing radical prostatectomy].
OBJECTIVE
Mecobalamin has been reported to be useful for peripheral nerve disorder. There have been no previous reports of the effects of mecobalamin on urinary and sexual function after nerve sparing radical prostatectomy. We examined the effects of the use of mecobalamin on urinary and erectile functions after nerve sparing radical prostatectomy.


METHODS
A total of 54 patients with localized prostatic cancer were prospectively randomized into 2 groups. The 27 patients in group A were treated with nerve sparing prostatectomy and mecobalamin 1,500 microg/day for 6 months. The 27 patients in group B were treated with nerve sparing prostatectomy alone. Urinary function (URF), urinary bother (URB), sexual function (SXF) and sexual bother (SXB) were evaluated using the University of California at Los Angeles Prostate Cancer Index (UCLA-PCI) before surgery, and 3, 6 and 12 months after surgery.


RESULTS
There were no significant differences in URF, URB, SXF or SXB between the two groups at any postoperative period. At 3 months after surgery, however, group A tended to have a better URF than group B (85.7 +/- 4.7 (mean +/- standard error) vs. 66.9 +/- 10.2) and URB (85.7 +/- 7.4 vs. 63.9 +/- 11.8) (p = 0.121, p = 0.168). At 12 months after surgery, both groups showed similar URF (86.4 +/- 7.4 vs. 81.8 +/- 4.2) and URB (86.5 +/- 8.3 vs. 84.5 +/- 4.7). Although the two groups had similar recovery phase of SXF, group A tended to report better SXB throughout the postoperative period.


CONCLUSIONS
This study did not demonstrate any significant effect of the use of mecobalamin on the recovery of urinary or sexual function after nerve sparing prostatectomy, although an early recovery effect on urinary function was suggested. A randomized controlled study with a larger population is warranted to fully elucidate the role of mecobalamin in the improvement of functional outcome after radical prostatectomy.
Matsushita
Mabumi
M
Department of Urology, Tohoku University Graduate School of Medicine.
Nakagawa
Haruo
H
Namiki
Shunichi
S
Ikeda
Yoshihiro
Y
Kaiho
Yasuhiro
Y
Kawamorita
Naoki
N
Ito
Akihiro
A
Ishidoya
Shigeto
S
Saito
Seiichi
S
Arai
Yoichi
Y
D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D010410:Penile Erection; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D013997:Time Factors; D014554:Urination; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000031:analogs & derivatives*
C019476:mecobalamin; D014805:Vitamin B 12