title: The flagellum-mitogen-activated protein kinase connection in Trypanosomatids: a key sensory role in parasite signalling and development?
abstract: Trypanosomatid parasites are the causative agents of severe human diseases such as sleeping sickness, Chagas disease and leishmaniases. These microorganisms are transmitted via different insect vectors and hence are confronted to changing environments during their infectious cycle in which they activate specific and complex patterns of differentiation. Several studies in Trypanosoma brucei and in different subspecies of Leishmania have shed light on the role of mitogen-activated protein (MAP) kinases in these processes. Surprisingly, several MAP kinases turned out to be involved in the control of flagellum length in the promastigote stage of Leishmania. Recently, a sensory function has been recognized for cilia and flagella in unicellular and multicellular eukaryotes. This review aims to stimulate discussions on the possibility that the Trypanosomatid flagellum could act as a sensory organ through the MAP kinase pathway, with the objective to encourage investigation of this new hypothesis through a series of proposed experimental approaches.
authors.affiliation: Institut Pasteur, CNRS URA 2581, Paris, France.
authors.forename: Brice
authors.initials: B
authors.lastname: Rotureau
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Morales
authors.forename: Philippe
authors.initials: P
authors.lastname: Bastin
authors.forename: Gerald F
authors.initials: GF
authors.lastname: Späth
mesh_terms: D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism / Q000502:physiology*; D005407:Flagella / Q000201:enzymology* / Q000502:physiology / Q000648:ultrastructure; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D014351:Trypanosomatina / Q000201:enzymology* / Q000472:pathogenicity / Q000502:physiology; D014774:Virulence
chemical_list: D048049:Extracellular Signal-Regulated MAP Kinases