Role of immunogenic fetuin A on L5178Y-R lymphoma tumorigenesis.
In the present study, we report the detection of immunogenic fetuin-A on L5178Y-R (LY-R) lymphoma cells. Fetuin-A was recognized by antibodies present in the serum of LY-R tumor-bearing and immunized mice, but not by sera of mice immunized with the non-tumorigenic variant LY-S or by healthy mouse sera. However, according with Western blot analysis with commercial anti-fetuin antibodies, fetuin-A is present in both cell types which suggests that the fetuin recognized by anti-LY-R antibodies is an immunogenic form associated only with the tumorigenic LY-R cells and might be involved in tumor progression in this lymphoma.
Caballero-Hernández
Diana
D
Departamento de Microbiología e Inmunología, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, Nuevo León, México.
Gomez-Flores
Ricardo
R
Tamez-Guerra
Patricia
P
Tamez-Guerra
Reyes
R
Rodríguez-Padilla
Cristina
C
D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000276:immunology / Q000502:physiology*; D045744:Cell Line, Tumor; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D008223:Lymphoma / Q000209:etiology*; D008565:Membrane Proteins / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D053719:Tandem Mass Spectrometry; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; C556357:Ahsg protein, mouse; D001798:Blood Proteins; D008565:Membrane Proteins; D060749:alpha-2-HS-Glycoprotein