title: Indices of fetal development derived from heart rate patterns.
abstract: BACKGROUND
  The fetal precursors of mental and cardiovascular disease caused by adverse prenatal environmental influences and manifesting in later age are an important issue of developmental medicine. However the number of measurable functional parameters of a fetus is limited. Evaluation of key parameters involving fetal autonomic control could permit an earlier detection of developmental problems and improved therapeutic strategies. Thus far, however, even the maturation of normal autonomic control has not been sufficiently assessed.
  
  
  OBJECTIVE
  The objective of the present work is to describe normal fetal maturation based on indices of autonomic heart rate modulation.
  
  
  METHODS
  Heart beat interval series were magnetocardiographically recorded with 1 kHz sampling rate over 30 min in 78 normal fetuses, gestational age (GA) 23-40 weeks. Indices considered were: number of accelerations (AC) and decelerations (DC), RMSSD, SDNN, and short-term/long-term autonomic information flows (AIF_NN, AIF_fVLF). These were measured from the entire 30 min data sets and from activity-specific subsets (10 min).
  
  
  RESULTS
  In the 30 min recordings: the number of AC increased, number of DC decreased, rMSSD and SDNN increased and AIF_fVLF increased with GA, but AIF_NN remained constant. In the 10 min subsets: SDNN increased in the active state but remained constant in the quiet state and AIF_NN decreased with GA in the quiet state.
  
  
  CONCLUSIONS
  Heart rate patterns from 30 min biomagnetic recordings may provide new indices with which to assess the normal and abnormal maturation of fetal autonomic control and to identify risk of possible disorders in later life.
authors.affiliation: University Hospital, Biomagnetic Center, Department of Neurology, Friedrich Schiller University of Jena, Germany. Dirk.Hoyer@biomag.uni-jena.de
authors.forename: Dirk
authors.initials: D
authors.lastname: Hoyer
authors.forename: Esther
authors.initials: E
authors.lastname: Heinicke
authors.forename: Susann
authors.initials: S
authors.lastname: Jaekel
authors.forename: Florian
authors.initials: F
authors.lastname: Tetschke
authors.forename: Dania
authors.initials: D
authors.lastname: Di Pietro Paolo
authors.forename: Jens
authors.initials: J
authors.lastname: Haueisen
authors.forename: Ekkehard
authors.initials: E
authors.lastname: Schleusner
authors.forename: Uwe
authors.initials: U
authors.lastname: Schneider
mesh_terms: D047109:Fetal Development; D006340:Heart Rate, Fetal; D006801:Humans