title: Inhibition of selectin binding by colloidal gold with functionalized shells.
abstract: Gold colloids with terminally functionalized sulfated thiol shells were found to bind to P- and L-selectins with IC(50) values in the picomolar range; branched acyclic epitopes show the highest affinity, whereas a sulfated carbohydrate mimetic provides the best selectivity.
authors.affiliation: Charité-Universitätsmedizin Berlin, CBF, Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, Hindenburgdamm 30, 12203 Berlin, Germany. jens.dernedde@charite.de
authors.forename: Jens
authors.initials: J
authors.lastname: Dernedde
authors.forename: Sven
authors.initials: S
authors.lastname: Enders
authors.forename: Hans-Ulrich
authors.initials: HU
authors.lastname: Reissig
authors.forename: Meike
authors.initials: M
authors.lastname: Roskamp
authors.forename: Sabine
authors.initials: S
authors.lastname: Schlecht
authors.forename: Shahla
authors.initials: S
authors.lastname: Yekta
mesh_terms: D000818:Animals; D001665:Binding Sites; D003260:Contact Inhibition; D004587:Electrophoresis, Agar Gel; D017979:Gold Colloid / Q000737:chemistry* / Q000378:metabolism; D020128:Inhibitory Concentration 50; D019041:L-Selectin / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism; D008024:Ligands; D019007:P-Selectin / Q000378:metabolism*
chemical_list: D017979:Gold Colloid; D008024:Ligands; D019007:P-Selectin; D019041:L-Selectin