title: Sodium valproate as a cause of recurrent transudative pleural effusion: a case report.
abstract: BACKGROUND
  There are few reported cases of neutrophilic pleural effusions associated with valproic acid therapy. Most of them are of eosinophilic exudates with or without blood eosinophilia.
  
  
  METHODS
  This case study describes a 70-year-old man with recurrent episodes of eosinophilic transudative pleural effusions associated with sodium valproate treatment. The recurrence of effusion after re-administration of the drug is strongly suggestive of an association between them. To the best of our knowledge, this is the first reported case with a pleural effusion with these characteristics caused by sodium valproate.
  
  
  CONCLUSIONS
  This is the first report in the literature, with a full understanding of the etiology but with an unknown drug mechanism. This case report is of interest to different medical specialists (such as pulmonologists, neurologists, cardiologists) and pharmacologists.
authors.affiliation: 1st Pulmonary Clinic, G,H, "G, Papanikolaou", Thessaloniki, Greece. strifon@med.auth.gr.
authors.forename: Stavros
authors.initials: S
authors.lastname: Tryfon
authors.forename: Maria
authors.initials: M
authors.lastname: Saroglou
authors.forename: Kosmas
authors.initials: K
authors.lastname: Kazanas
authors.forename: Charalambos
authors.initials: C
authors.lastname: Mermigkis
authors.forename: Kostas
authors.initials: K
authors.lastname: Psathakis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Galanis