[Development of the role of micrornas regulation in osteogenesis].
OBJECTIVE
To review the progress, controversy and trend in the regulation and mechanism of the microRNAs (miRNAs) during the osteogenesis.


METHODS
Recent literature concerning regulation and mechanism of the miRNAs during the osteogenesis was extensively reviewed, summarized and analyzed.


RESULTS
Recently miRNAs was a hot topic for osteogenesis. More and more materials showed its important role in ossification, but its definite mechanism was not clear.


CONCLUSIONS
Osteogenesis can be strengthened by miRNAs technology, which has a bright future and may also provide the molecular mechanism. The study on miRNAs of osteogenesis can provide a model to analyze and compare the osteogenetic effects of novel drugs.
Lin
Zihong
Z
Department of Joint Surgery, First Affiliated Hospital of Zhongshan University, Guangzhou Guangdong, 510080, P.R. China.
Lin
Senhao
S
Huang
Yingxiong
Y
Zhang
Junlong
J
Fu
Ming
M
D000818:Animals; D002454:Cell Differentiation; D006801:Humans; D035683:MicroRNAs; D010006:Osteoblasts / Q000166:cytology*; D010012:Osteogenesis / Q000235:genetics*
D035683:MicroRNAs