Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus.
Drug-resistant bacteria are becoming more prevalent both in the community and in hospitals. In a search for new antibiotic leads, we used a high-throughput natural products chemistry approach to isolate one new (1) and two known (2, 3) dammarane-type triterpenes with mass-limited material from the African plant Oncoba manii. The new compound was determined by spectroscopic methods to be 1beta,2alpha,3beta,20(R)-tetrahydroxydammar-24-ene 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranoside. Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA).
Garo
Eliane
E
Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., Saint Louis, Missouri 63114, USA.
Hung
Chia S
CS
Williams
Russell B
RB
Olson
Krista M
KM
Hu
Jin-Feng
JF
Rice
Stephanie M
SM
Hough
Grayson W
GW
Goering
Matt G
MG
O'Neil-Johnson
Mark
M
Eldridge
Gary R
GR
Starks
Courtney M
CM
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031308:Salicaceae / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology; D000097669:Dammaranes
D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; D014640:Vancomycin; D000097669:Dammaranes; C543381:1beta,2alpha,3beta,20(R)-tetrahydroxydammar-24-ene 3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranoside