title: Short synthesis of a novel class of salvinorin A analogs with hemiacetalic structure.
abstract: Novel semisynthetic analogs of salvinorin A, a full agonist having extraordinary affinity as well as selectivity for the κ-opioid receptor (KOR), were obtained in good yields. The derivatives are remarkable for their unusual and unique hemiacetal structure in the salvinorin series of compounds. The formation of the hemiacetal occurs with epimerization at C-12, thus preserving the original configuration of salvinorin A. The dimethyl ester derivative of the hemiacetal was found to have an affinity for both KOR and MOR (μ-opioid receptor).
authors.affiliation: Department of Phamacognosy, School of Pharmacy, University of Mississippi, University, MS 38677-1848, USA.
authors.forename: Ruslan V
authors.initials: RV
authors.lastname: Bikbulatov
authors.forename: Jeremy
authors.initials: J
authors.lastname: Stewart
authors.forename: Wentao
authors.initials: W
authors.lastname: Jin
authors.forename: Feng
authors.initials: F
authors.lastname: Yan
authors.forename: Bryan L
authors.initials: BL
authors.lastname: Roth
authors.forename: Daneel
authors.initials: D
authors.lastname: Ferreira
authors.forename: Jordan K
authors.initials: JK
authors.lastname: Zjawiony