title: Complex chromosomal rearrangement involving chromosomes 1, 4 and 22 in an infertile male: case report and literature review.
abstract: Here we describe a rare case of an apparently balanced karyotype of 46, XY, t(1;22;4)(p22.3;q11.1;q31.1) in a infertile male with oligoastenoteratozoospermia (OAT). He was the second patient with complex chromosomal rearrangement (CCR) referred to our center because of infertility. We also review reports on 24 males carrying CCRs with spermatogenesis failure or a malformed child, to provide information on the reproductive outcome of male CCR carriers.
authors.affiliation: Reproductive Genetics Department, Reproductive Medicine Research Center, Royan Institute, ACECR, Tehran, Iran.
authors.forename: I
authors.initials: I
authors.lastname: Salahshourifar
authors.forename: N
authors.initials: N
authors.lastname: Shahrokhshahi
authors.forename: T
authors.initials: T
authors.lastname: Tavakolzadeh
authors.forename: Z
authors.initials: Z
authors.lastname: Beheshti
authors.forename: H
authors.initials: H
authors.lastname: Gourabi
mesh_terms: D053713:Azoospermia / Q000235:genetics; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002875:Chromosomes / Q000648:ultrastructure*; D002878:Chromosomes, Human, Pair 1; D002892:Chromosomes, Human, Pair 22; D002894:Chromosomes, Human, Pair 4; D003582:Cytogenetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D009845:Oligospermia / Q000235:genetics; D013091:Spermatogenesis