In vivo tracking of cellular therapeutics using magnetic resonance imaging.
BACKGROUND
The success of many cell-based therapies is highly dependent on the accurate delivery, dosing and trafficking of the cellular therapeutic. In vivo magnetic resonance (MR) cell tracking provides a means to non-invasively and longitudinally evaluate these parameters for cellular therapy.


OBJECTIVE
To provide an overview of MR cell tracking and how cellular therapeutics might be improved by utilizing this technology.


METHODS
We focused on the technologies utilized for stem cell and immunotherapies in preclinical models of disease.


CONCLUSIONS
New technologies in MR cell tracking will soon take the field beyond preclinical studies and begin to show benefits in clinical trials of novel experimental cell-based therapies.
Long
Christoper M
CM
The Johns Hopkins University, School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, Baltimore, USA.
Bulte
Jeff W M
JW
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007167:Immunotherapy; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009369:Neoplasms / Q000628:therapy*; D013194:Staining and Labeling; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology*