Kounis syndrome: two extraordinary cases.
Acute myocardial infarction occurring during the course of an allergic reaction constitutes the Kounis syndrome. This syndrome is caused by inflammatory mediators released mainly from activated mast cells and the interrelated via bidirectional stimuli macrophages and T-lymphocytes. Since activated mast cells abound at the areas of plaque erosion or rupture in patients suffering from acute myocardial infarction a common pathway between allergic and non allergic coronary events seems to exist. Two cases of this syndrome are described, the first following nicorette transdermal application and subsequent finger pricking by fish bone and the second after ciprofloxacin administration.
Almpanis
George
G
Siahos
Simos
S
Karogiannis
Nicholas C
NC
Mazarakis
Andreas
A
Niarchos
Constantinos
C
Kounis
George N
GN
Kounis
Nicholas G
NG
D000369:Aged, 80 and over; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects; D002939:Ciprofloxacin / Q000009:adverse effects; D003329:Coronary Vasospasm / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005399:Fishes; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology*
D000890:Anti-Infective Agents; D002939:Ciprofloxacin