Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome.
OBJECTIVE
To investigate the correlation between serum 25-hydroxyvitamin D (25-OH-VD) concentrations and metabolic parameters in obese and non-obese women with polycystic ovary syndrome (PCOS).


METHODS
One hundred women with PCOS were divided into two groups, obese and non-obese, according to their body mass index (BMI). Waist-to-hip ratio (WHR), Ferriman-Gallwey score, homeostasis model assessment of insulin resistance (HOMA-IR), total cholesterol, triglycerides, calcium, 25-OH-VD, LH/FSH, total testosterone, and DHEAS were measured.


RESULTS
The serum 25-OH-VD mean levels were 56.31% lower in the obese PCOS patients. There was an association of increased HOMA-IR, BMI, WHR, triglycerides, total testosterone, and DHEAS with decreased 25-OH-VD concentrations in the obese PCOS patients.


CONCLUSIONS
Low serum 25-OH-VD concentrations result from the presence of obesity and insulin resistance. However, the dependency between PCOS and hypovitaminosis D is questionable. Hypovitaminosis D should be kept in mind while managing obese women with PCOS.
Yildizhan
Recep
R
Department of Obstetrics and Gynecology, School of Medicine, Yuzuncu Yil University, Van, Turkey. recepyildizhan@yahoo.com
Kurdoglu
Mertihan
M
Adali
Ertan
E
Kolusari
Ali
A
Yildizhan
Begum
B
Sahin
Hanim Guler
HG
Kamaci
Mansur
M
D000328:Adult; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications; D011446:Prospective Studies; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
D014807:Vitamin D; C104450:25-hydroxyvitamin D