A one-pot synthesis of functionalized thiazoles from acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate.
An efficient one-pot synthesis of ethyl 2-(4-aryl-2-dialkylamino-1,3-thiazole-5-yl)-2-oxoacetates using acid chlorides, secondary amines, ethyl bromopyruvate, and ammonium thiocyanate is described.
Yavari
Issa
I
Chemistry Department, Tarbiat Modares University, Tehran, Iran. yavarisa@modares.ac.ir
Hossaini
Zinatossadat
Z
Sabbaghan
Maryam
M
Ghazanfarpour-Darjani
Majid
M
D000588:Amines / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D008958:Models, Molecular; D011773:Pyruvates / Q000737:chemistry*; D013844:Thiazoles / Q000138:chemical synthesis*; D013861:Thiocyanates / Q000737:chemistry*
D000588:Amines; D002712:Chlorides; D011773:Pyruvates; D013844:Thiazoles; D013861:Thiocyanates; C017092:bromopyruvate; C026976:thiocyanic acid