[The prolipherative and proapoptotic activity of limfoid nodules cells in the hypertrophic pharyngeal tonsil].
The human immune system recognize and eliminate strange antigens by present of lymphoid cell clones, which to come into being in consequence of clonal proliferation inducted by contact with the antigen. The cell clones to be due to the somatic mutations and recognize antigens incorrectly are eliminate by apoptosis.


OBJECTIVE
To estimation of expression of chosen proliferative and proapoptotic proteins in lymphoid follicles and extra-follicular region of pharyngeal tonsil.


METHODS
Histochemical examination of chosen proapoptotic (p53, Bax) and proliferative (Ki-67, PCNA) proteins in adenoidectomised pharyngeal tonsil was done.


RESULTS
The most greater proliferation activity was in the germinal centers of lymphoid follicles, much less in the mantle zone and in the extrafollicular region. Similarly, maximal expression of proapoptotic proteins was in germinal centers of tonsil lymphoid follicles, the least in the mantle zone.


CONCLUSIONS
The high proliferative and proapoptotic activity of lymphoid follicles germinal centers to bear evidence of clonal selection of undistinguished lymphoid cells to come into being by somatic mutations.
Szczepański
Marek
M
Uniwersytet Medyczny w Białymstoku, Klinika Neonatologii. szczepanski5@gazeta.pl
Gryko
Anna
A
Kamianowska
Monika
M
Dziecioł
Janusz
J
D000234:Adenoids / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D017209:Apoptosis / Q000276:immunology*; D049109:Cell Proliferation; D006801:Humans; D006984:Hypertrophy / Q000276:immunology / Q000473:pathology; D019394:Ki-67 Antigen / Q000378:metabolism; D008221:Lymphoid Tissue / Q000276:immunology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism
D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein