title: Synthesis and in vitro activity of dicationic bis-benzimidazoles as a new class of anti-MRSA and anti-VRE agents.
abstract: A new class of novel bis-benzimidazole diamidine compounds have been synthesized and evaluated for in vitro antibacterial activities, including drug-resistant bacterial strains. Anti-MRSA and anti-VRE activities of the most potent compound 1 were more active than Vancomycin. The mechanism of action for this class of compounds appears to be different from existing antibiotics. Bis-benzimidazole diamidine compounds have potential for further investigation as a new class of potent anti-MRSA and anti-VRE agents.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, GA 30303-3083, USA.
authors.forename: Laixing
authors.initials: L
authors.lastname: Hu
authors.forename: Maureen L
authors.initials: ML
authors.lastname: Kully
authors.forename: David W
authors.initials: DW
authors.lastname: Boykin
authors.forename: Norman
authors.initials: N
authors.lastname: Abood
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000145:classification / Q000494:pharmacology; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D016984:Enterococcus faecium / Q000187:drug effects*; D016106:Methicillin Resistance / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D020713:Vancomycin Resistance / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; C009712:bis-benzimidazole