title: Long-term effects of the oral adsorbent, AST-120, in patients with chronic renal failure.
abstract: The oral adsorbent AST-120 has been widely used in Japan to delay the initiation of dialysis therapy in patients with chronic renal failure. This study evaluated the long-term effects of AST-120 in patients with chronic renal failure who had not previously undergone dialysis. One hundred out-patients were prospectively enrolled and prescribed 6 g/day oral AST-120 for >or= 1 year. The clinical effectiveness of AST-120 was evaluated by comparing changes in the slope of the reciprocal serum creatinine-time plot (1/sCr slope) before and after AST-120 administration. The 1/sCr slope improved significantly after >or= 1 year of AST-120 treatment and greatest improvement was observed in patients with the longest AST-120 administration period (> 30 months). The results suggest that long-term treatment with AST-120 may be beneficial for chronic renal failure patients in the pre-dialysis stage.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Juntendo University Nerima Hospital, Tokyo, Japan. kuni@juntendo-nerima.jp
authors.forename: K
authors.initials: K
authors.lastname: Maeda
authors.forename: C
authors.initials: C
authors.lastname: Hamada
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: I
authors.initials: I
authors.lastname: Shou
authors.forename: M
authors.initials: M
authors.lastname: Wakabayashi
authors.forename: M
authors.initials: M
authors.lastname: Fukui
authors.forename: S
authors.initials: S
authors.lastname: Horikoshi
authors.forename: Y
authors.initials: Y
authors.lastname: Tomino
mesh_terms: D000284:Administration, Oral; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002244:Carbon / Q000008:administration & dosage* / Q000378:metabolism* / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000008:administration & dosage* / Q000378:metabolism* / Q000627:therapeutic use; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D010087:Oxides; D002244:Carbon; C040896:AST 120; D003404:Creatinine