title: Small dense low-density lipoprotein concentration and oxidative susceptibility changes after consumption of soybean oil, rice bran oil, palm oil and mixed rice bran/palm oil in hypercholesterolaemic women.
abstract: The effects of a diet containing soybean oil (SBO), rice bran oil (RBO), palm oil (PO) or a RBO/PO (3:1) mixture on the composition and oxidation of small dense low-density lipoproteins (sdLDL) in 16 hypercholesterolaemic women were investigated. During the 8-week control period, participants consumed a free-choice weight-maintaining diet comprising carbohydrate (55% energy), protein (15% energy) and fat (30% energy) with < 300 mg/day of cholesterol. During each 10-week study period, participants consumed this same diet but with the addition of one of the three test oils or the RBO/PO mixture. Total cholesterol and low-density lipoprotein (LDL)-cholesterol levels were significantly reduced during SBO, RBO and RBO/PO consumption, while high-density lipoprotein cholesterol was significantly decreased by SBO consumption. There was a significant reduction in sdLDL-cholesterol levels only after using SBO and it tended to be reduced during RBO/PO consumption, whereas it was significantly increased following PO consumption. The sdLDL oxidation lag time was significantly increased during PO, RBO/PO and RBO consumption, but significantly reduced following SBO. The results for the RBO/PO mixture suggest that this oil mixture might further reduce the risk of atherosclerosis.
authors.affiliation: Graduate Programme of Nutrition, Institute of Nutrition, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Utarwuthipong
authors.forename: S
authors.initials: S
authors.lastname: Komindr
authors.forename: V
authors.initials: V
authors.lastname: Pakpeankitvatana
authors.forename: S
authors.initials: S
authors.lastname: Songchitsomboon
authors.forename: N
authors.initials: N
authors.lastname: Thongmuang
mesh_terms: D000328:Adult; D000368:Aged; D004198:Disease Susceptibility / Q000097:blood / Q000178:diet therapy; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000178:diet therapy; D008077:Lipoproteins, LDL / Q000097:blood*; D008875:Middle Aged; D010084:Oxidation-Reduction / Q000187:drug effects; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D000073879:Rice Bran Oil; D013024:Soybean Oil / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D008077:Lipoproteins, LDL; D010938:Plant Oils; D013024:Soybean Oil; D000073879:Rice Bran Oil