title: SNPs in BRAP associated with risk of myocardial infarction in Asian populations.
abstract: Myocardial infarction is a common disease and among the leading causes of death in the world. We previously reported association of variants in LGALS2, encoding galectin-2, with myocardial infarction susceptibility in a case-control association study in a Japanese population. Here we identify BRAP (BRCA1-associated protein) as a galectin-2-binding protein. We report an association of SNPs in BRAP with myocardial infarction risk in a large Japanese cohort (P = 3.0 x 10(-18), OR = 1.48, 2,475 cases and 2,778 controls), with replication in additional Japanese and Taiwanese cohorts (P = 4.4 x 10(-6), 862 cases and 1,113 controls and P = 4.7 x 10(-3), 349 cases and 994 controls, respectively). BRAP expression was observed in smooth muscle cells (SMCs) and macrophages in human atherosclerotic lesions. BRAP knockdown by siRNA using cultured coronary endothelial cells suppressed activation of NF-kappaB, a central mediator of inflammation.
authors.affiliation: Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama 230-0045, Japan.
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ozaki
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sato
authors.forename: Katsumi
authors.initials: K
authors.lastname: Inoue
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sakata
authors.forename: Hiroya
authors.initials: H
authors.lastname: Mizuno
authors.forename: Tsung-Hsien
authors.initials: TH
authors.lastname: Lin
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Asako
authors.initials: A
authors.lastname: Aoki
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Onouchi
authors.forename: Sheng-Hsiung
authors.initials: SH
authors.lastname: Sheu
authors.forename: Shiro
authors.initials: S
authors.lastname: Ikegawa
authors.forename: Keita
authors.initials: K
authors.lastname: Odashiro
authors.forename: Masakiyo
authors.initials: M
authors.lastname: Nobuyoshi
authors.forename: Suh-Hang H
authors.initials: SH
authors.lastname: Juo
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D001208:Asia; D050197:Atherosclerosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D019556:COS Cells; D016022:Case-Control Studies; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000378:metabolism; D009203:Myocardial Infarction / Q000235:genetics*; D032389:Myocytes, Smooth Muscle / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000502:physiology*; D011485:Protein Binding; D034741:RNA, Small Interfering / Q000494:pharmacology; D012307:Risk Factors; D044767:Ubiquitin-Protein Ligases / Q000235:genetics* / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D034741:RNA, Small Interfering; C111164:BRAP protein, human; D044767:Ubiquitin-Protein Ligases