title: Unison: an integrated platform for computational biology discovery.
abstract: This paper describes the design and applications of Unison, a comprehensive and integrated warehouse of protein sequences, diverse precomputed predictions, and other biological data. Unison provides a practical solution to the burden of preparing data for computational discovery projects, enables holistic feature-based mining queries regarding protein composition and functions, and provides a foundation for the development of new tools. Unison is available for immediate use online via direct database connections and a web interface. In addition, the database schema, command line tools, web interface, and non-proprietary precomputed predictions are released under the Academic Free License and available for download at http://unison-db.org/. This project has resulted in a system that significantly reduces several practical impediments to the initiation of computational biology discovery projects.
authors.affiliation: Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA. rkh@gene.com
authors.forename: Reece K
authors.initials: RK
authors.lastname: Hart
authors.forename: Kiran
authors.initials: K
authors.lastname: Mukhyala
mesh_terms: D020816:Amino Acid Motifs; D001699:Biometry / Q000379:methods*; D016208:Databases, Factual; D030562:Databases, Protein; D020407:Internet; D011971:Receptors, Immunologic / Q000737:chemistry / Q000235:genetics; D012984:Software; D014584:User-Computer Interface
chemical_list: D011971:Receptors, Immunologic