Sensory detection thresholds are modulated across the cardiac cycle: evidence that cutaneous sensibility is greatest for systolic stimulation.
The visceral afferent feedback hypothesis proposes that sensorimotor function is impaired by cortical inhibition associated with increased baroreceptor activation. This study is the first to examine the effects of naturally occurring variations in baroreceptor activity across the cardiac cycle on cutaneous sensory detection thresholds. In each trial, an electrocutaneous stimulus was delivered to the index finger at one of three intervals (0, 300, 600 ms) after the R-wave of the electrocardiogram. Separate interleaving up-down staircases were used to determine the 50% detection threshold for each R-wave to stimulation interval. Cutaneous sensory detection thresholds were lower for stimuli presented at R+300 ms than R+0 ms or R+600 ms. The finding that cutaneous sensibility was greater when stimulated during systole than diastole may be accounted for by a modified afferent feedback hypothesis.
Edwards
L
L
Department of Human Sciences, Loughborough University, Leicestershire, UK. L.Edwards@lboro.ac.uk
Ring
C
C
McIntyre
D
D
Winer
J B
JB
Martin
U
U
D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D005712:Galvanic Skin Response; D006321:Heart / Q000502:physiology*; D006801:Humans; D008297:Male; D011311:Pressoreceptors / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology*; D012867:Skin / Q000294:innervation; D012879:Skin Physiological Phenomena; D013599:Systole / Q000502:physiology