title: Structure of the thioredoxin-fold domain of human phosducin-like protein 2.
abstract: Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.
authors.affiliation: Institute of Protein Research, Tongji University, Shanghai 200092, People's Republic of China.
authors.forename: Xiaochu
authors.initials: X
authors.lastname: Lou
authors.forename: Rui
authors.initials: R
authors.lastname: Bao
authors.forename: Cong Zhao
authors.initials: CZ
authors.lastname: Zhou
authors.forename: Yuxing
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D051381:Rats; D013879:Thioredoxins / Q000737:chemistry*
chemical_list: D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; C498321:PDCL2 protein, human; D013879:Thioredoxins