title: Evaluation of the antifungal potential of Brazilian Cerrado medicinal plants.
abstract: Therapeutic limitations, development of fungal drug resistance, drug-related toxicity, drug interactions and insufficient bioavailability of the currently available antifungal drugs have made the development of drugs necessary that would be able to treat the emerging fungal infections. The Cerrado is the second greater biome of Brazil and it was identified as one of the most distinguished biomes of South America, becoming an important source of innovative vegetal molecules to treat several conditions. Thus, the objective of this study was to evaluate the antifungal potential of Cerrado plants, mainly those used to treat infections and wounds. A total of 57 extracts were screened by the agar-well diffusion technique against Candida albicans and Trichophyton rubrum. The most promising extracts were tested in smaller concentrations and their minimal inhibitory concentrations (MIC) were determined by microdilution method. Results were analysed statistically by anova tests. Extracts of Kielmeyera coriacea, Renealmia alpinia, Stryphnodendron adstringens and Tabebuia caraiba were very active against T. rubrum, presented geometric means of the MIC values between 170.39 and 23.23 microg ml(-1). Extracts of Cerrado plants are of particular interest as source of new agents for the treatment of dermatophytic infections.
authors.affiliation: Laboratório de Farmacognosia, Universidade de Brasília, Brasília, DF, Brazil.
authors.forename: Fernanda
authors.initials: F
authors.lastname: Melo e Silva
authors.forename: José Elias
authors.initials: JE
authors.lastname: de Paula
authors.forename: Laila Salmen
authors.initials: LS
authors.lastname: Espindola
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001938:Brazil; D002176:Candida albicans / Q000187:drug effects*; D028084:Clusiaceae / Q000737:chemistry; D007887:Fabaceae / Q000737:chemistry; D006801:Humans; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal / Q000737:chemistry*; D029663:Tabebuia / Q000737:chemistry; D014249:Trichophyton / Q000187:drug effects*; D030521:Zingiberaceae / Q000737:chemistry
chemical_list: D000935:Antifungal Agents