title: Massive aneurysmal dilatation of a depopulated ureteric hemodialysis xenograft.
abstract: Use of depopulated bovine ureteric xenografts for hemodialysis vascular access has recently been described. Cellular components have been removed, giving a connective tissue matrix which can be neocellularized, retaining native biomechanics. A 24-year-old male with end-stage renal disease from focal segmental glomerulosclerosis presented with particularly difficult vascular access. A depopulated bovine ureteric xenograft was implanted from the left subclavian artery to innominate vein. It became massively aneurysmal, requiring emergency embolization. Biopsy of the graft stained positive for alpha-gal. We believe this is the first reported case of massive aneurysmal dilatation of a depopulated bovine ureteric xenograft.
authors.affiliation: Department of Renal Medicine, The Leeds Teaching Hoispitals NHS Trust, UK. mattws1@googlemail.com
authors.forename: Matthew P Welberry
authors.initials: MP
authors.lastname: Smith
authors.forename: James Ian
authors.initials: JI
authors.lastname: Spark
authors.forename: Jai V
authors.initials: JV
authors.lastname: Patel
authors.forename: David J
authors.initials: DJ
authors.lastname: Border
authors.forename: Dilip
authors.initials: D
authors.lastname: Oswal
authors.forename: Andrew J P
authors.initials: AJ
authors.lastname: Lewington
mesh_terms: D000328:Adult; D000783:Aneurysm / Q000209:etiology*; D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000379:methods*; D001705:Bioprosthesis / Q000009:adverse effects*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D016121:Brachiocephalic Veins / Q000601:surgery; D002417:Cattle; D006801:Humans; D008297:Male; D006435:Renal Dialysis / Q000009:adverse effects* / Q000379:methods; D013348:Subclavian Artery / Q000601:surgery; D014183:Transplantation, Heterologous; D014513:Ureter / Q000637:transplantation*