title: Neural correlates of automatic and controlled auditory processing in schizophrenia.
abstract: Individuals with schizophrenia demonstrate impairments in selective attention and sensory processing. The authors assessed differences in brain function between 26 participants with schizophrenia and 17 comparison subjects engaged in automatic (unattended) and controlled (attended) auditory information processing using event-related functional MRI. Lower regional neural activation during automatic auditory processing in the schizophrenia group was not confined to just the temporal lobe, but also extended to prefrontal regions. Controlled auditory processing was associated with a distributed frontotemporal and subcortical dysfunction. Differences in activation between these two modes of auditory information processing were more pronounced in the comparison group than in the patient group.
authors.affiliation: Duke-UNC Brain Imaging and Analysis Center, Department of Psychiatry, Duke University, Box 3918, Durham, NC 27707, USA. morey@biac.duke.edu
authors.forename: Rajendra A
authors.initials: RA
authors.lastname: Morey
authors.forename: Teresa V
authors.initials: TV
authors.lastname: Mitchell
authors.forename: Seniha
authors.initials: S
authors.lastname: Inan
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Lieberman
authors.forename: Aysenil
authors.initials: A
authors.lastname: Belger
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology; D012565:Schizophrenic Psychology