An emissive C analog distinguishes between G, 8-oxoG, and T.
A minimally disruptive fluorescent dC analog provides a rapid and non-destructive method for in vitro detection of G, 8-oxoG, and T, the downstream transverse mutation product.
Greco
Nicholas J
NJ
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, USA.
Sinkeldam
Renatus W
RW
Tor
Yitzhak
Y
D004249:DNA Damage; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006147:Guanine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry; D015394:Molecular Structure; D009154:Mutation; D010084:Oxidation-Reduction; D018384:Oxidative Stress
D005456:Fluorescent Dyes; C024829:8-hydroxyguanine; D006147:Guanine