[Modulating effect of serotonin on the development of human leukocytes apoptosis induced by Yersinia].
Effect of biogenic amine serotonin on the development of human blood leukocytes during interaction with species from Yersinia genus (Y. pestis EV, Y. pseudotuberculosis serovars I and IV, Y. enterocolitica serovars 09 and 03) was studied in model system in vitro using flow cytofluorometry. Serotonin in concentration 10(-5) M had differently marked effects on Yersinia spp.-induced apoptosis of leukocytes. Pattern of the observed changes depended from species and serovar of Yersinia. Serotonin inhibited development of early (after 6 hours) apoptosis of leukocytes induced by Y. pestis and Y. pseudotuberculosis serovar I.
Shchukovskaia
T N
TN
Kliueva
S N
SN
Kravtsov
A L
AL
Kozlova
E A
EA
Kutyrev
V V
VV
D017209:Apoptosis / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007962:Leukocytes / Q000276:immunology* / Q000382:microbiology; D012701:Serotonin / Q000276:immunology* / Q000494:pharmacology; D013045:Species Specificity; D015008:Yersinia enterocolitica / Q000276:immunology*; D015010:Yersinia pestis / Q000276:immunology*; D015011:Yersinia pseudotuberculosis / Q000276:immunology*
D012701:Serotonin