title: IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn's disease in Hungarian patients.
abstract: OBJECTIVE
  We investigated the possible association of IBD with C1672T of SLC22A4 and G-207C of SLC22A5 alleles, and with the novel IGR2096a_1 (rs12521868) and IGR2198a_1 (rs11739135) susceptibility loci, all located on IBD5 locus of chromosome 5q31.
  
  
  METHODS
  DNA of 217 Crohn's disease, 252 ulcerative colitis, and 290 control patients were analyzed by polymerase chain reaction/restriction fragment length polymorphism methods.
  
  
  RESULTS
  Neither the C1672T and G-207C alleles, nor the TC haplotype were found to be risk factors. By contrast, the minor allele frequencies of IGR2096a_1 T (47.2%) and IGR2198a_1 C (45.9%) were increased in Crohn's disease compared with the controls (38.2% and 37.7%, respectively; p < 0.05); multivariate regression analysis revealed a risk nature for Crohn's disease (OR = 1.748, 95% CI 1.186-2.574; p = 0.007 for T allele, OR = 1.646, 95% CI 1.119-2.423, p = 0.011 for C allele of IGRs).
  
  
  CONCLUSIONS
  The data suggest a special haplotype arrangement of susceptibility genes at the IBD5 locus in Hungarians, which nation differs historically from the surrounding Caucasian ethnicities in its origin.
authors.affiliation: Department of Medicine and Gastroenterology, Markusovszky Hospital, Szombathely, Hungary.
authors.forename: Lilla
authors.initials: L
authors.lastname: Lakner
authors.forename: Veronika
authors.initials: V
authors.lastname: Csöngei
authors.forename: Patrícia
authors.initials: P
authors.lastname: Sarlós
authors.forename: Luca
authors.initials: L
authors.lastname: Járomi
authors.forename: Eniko
authors.initials: E
authors.lastname: Sáfrány
authors.forename: Márta
authors.initials: M
authors.lastname: Varga
authors.forename: Péter
authors.initials: P
authors.lastname: Orosz
authors.forename: Lili
authors.initials: L
authors.lastname: Magyari
authors.forename: Judit
authors.initials: J
authors.lastname: Bene
authors.forename: Pál
authors.initials: P
authors.lastname: Miheller
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Tulassay
authors.forename: Béla
authors.initials: B
authors.lastname: Melegh
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D003093:Colitis, Ulcerative / Q000235:genetics; D003424:Crohn Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006814:Hungary; D008297:Male; D044465:White People / Q000235:genetics*