Pleiotropic effects of fenofibrate.
Fenofibrate represents the most commonly used fibric acid derivative. The drug exerts its metabolic effects by modulating the expression of several genes involved in lipoprotein metabolism. In addition, numerous studies suggest that fenofibrate may also affect the progression of the atherosclerotic process by several lipid-independent mechanisms. This review considers the clinical pharmacology of fenofibrate and the current evidence on the pleiotropic effects of this fibric acid derivative.
Tsimihodimos
V
V
Department of Internal Medicine, Medical School, University of Ioannina, Ioannina, Greece.
Liberopoulos
E
E
Elisaf
M
M
D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000503:physiopathology; D018450:Disease Progression; D011345:Fenofibrate / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008074:Lipoproteins / Q000187:drug effects / Q000378:metabolism
D000960:Hypolipidemic Agents; D008074:Lipoproteins; D011345:Fenofibrate