title: Aliskiren: a novel renin inhibitor for hypertension.
abstract: Hypertension is one of the major causes of cardiovascular morbidity. Most patients who are on treatment for hypertension fail to achieve adequate control with the existing therapy and rates of cardiovascular morbidity remain high. As the renin-angiotensin-aldosterone system is strongly implicated in the development of hypertension-related target organ damage, intensive efforts have been devoted towards the development of drugs targeting this system. In addition to angiotensin converting enzyme inhibitors and angiotensin receptor blockers, inhibition of renin has also become a clinical reality. Aliskiren, a novel renin inhibitor, has overcome a number of shortcomings of existing drugs and is now available to address angiotensin production directly at its rate-limiting step.
authors.affiliation: Department of Pharmacology, Maulana Azad Medical College, Bahadur Shah Zafar Marg, Delhi, India. vandana_muskan@rediffmail.com
authors.forename: Vandana
authors.initials: V
authors.lastname: Tayal
authors.forename: Bhupinder Singh
authors.initials: BS
authors.lastname: Kalra
mesh_terms: D000577:Amides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005650:Fumarates / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D000092502:Renin Inhibitors
chemical_list: D000577:Amides; D005650:Fumarates; D000092502:Renin Inhibitors; C446481:aliskiren