Influence of the hOCT2 inhibitor cimetidine on the cellular accumulation and cytotoxicity of oxaliplatin.
Buss
I
I
Department of Clinical Pharmacy, University of Bonn, Germany.
Kalayda
G V
GV
Marques-Gallego
P
P
Reedijk
J
J
Jaehde
U
U
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002927:Cimetidine / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004354:Drug Screening Assays, Antitumor; D005544:Forecasting; D006635:Histamine H2 Antagonists / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D015394:Molecular Structure; D027701:Organic Cation Transport Proteins / Q000037:antagonists & inhibitors*; D000075102:Organic Cation Transporter 2; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D000077150:Oxaliplatin; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D006635:Histamine H2 Antagonists; D027701:Organic Cation Transport Proteins; D000075102:Organic Cation Transporter 2; D009944:Organoplatinum Compounds; C491013:SLC22A2 protein, human; D000077150:Oxaliplatin; D002927:Cimetidine