Allantofuranone, a new antifungal antibiotic from Allantophomopsis lycopodina IBWF58B-05A.
In a screening for new bioactive compounds, the extract of Allantophomopsis lycopodina strain IBWF58B-05A, an imperfect ascomycete, was found to exhibit strong but rather selective antibiotic activity against Paecilomyces variotii. The bioactivity-guided isolation yielded allantofuranone, a new and uncommon gamma-lactone. This compound showed antifungal activity against P. variotii and Penicillium species. This paper describes the isolation, structure elucidation and biological characteristics of allantofuranone.
Schüffler
Anja
A
Department of Biotechnology, University of Kaiserslautern, Kaiserslautern, Germany.
Kautz
Daniela
D
Liermann
Johannes C
JC
Opatz
Till
T
Anke
Timm
T
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005285:Fermentation; D005658:Fungi / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared; D029799:Vaccinium macrocarpon / Q000382:microbiology
D000935:Antifungal Agents; C544237:allantofuranone; D015107:4-Butyrolactone