title: Photogenerated quinone methides as protein affinity labeling reagents.
abstract: Photogenerated quinine methides (QMs) can act as highly specific light-controllable protein affinity labeling reagents, broadening their applications to the study of protein-ligand and protein-protein interactions. The reactions between QMs and nucleophiles are less heterogeneous than those of other photogenerated active intermediates such as carbenes and nitrenes, making it easier to identify labeled species.
authors.affiliation: Department of Cell Biology and Molecular Genetics, University of Maryland College Park, College Park, MD 20742, USA.
authors.forename: Jiangsong
authors.initials: J
authors.lastname: Jiang
authors.forename: Dexing
authors.initials: D
authors.lastname: Zeng
authors.forename: Shuwei
authors.initials: S
authors.lastname: Li
mesh_terms: D000345:Affinity Labels; D000595:Amino Acid Sequence; D045563:Indolequinones / Q000737:chemistry*; D008958:Models, Molecular; D010782:Photolysis; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
chemical_list: D000345:Affinity Labels; D045563:Indolequinones; D011506:Proteins; C068040:quinone methide