[The role of Paenibacillus polymyxa lectin in the macrophages-mediated killing of bacteria].
Influence of lectin LII of Paenibacillus polymyxa 1460, specific for galactosamine, glucuronic acid, fructose-1,6-diphosphate, and glucosamine, on mechanisms of oxygen-dependent and oxygen-independent killing of bacteria was reviewed. It was shown that the lectin modulates the activity of some microbicide factors in the cytoplasm of macrophages before phagocytosis. Increased activity of myeloperoxidase and acid phosphatase, enhanced formation of active forms of oxygen in alveolar macrophages, increased level of cationic proteins and decreased activity of alkaline phosphatase in peritoneal macrophages was observed.
Abrosimova
O V
OV
Tikhomirova
E I
EI
Karpunina
L V
LV
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000378:metabolism; D001419:Bacteria / Q000737:chemistry / Q000276:immunology*; D001426:Bacterial Proteins / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology; D037102:Lectins / Q000276:immunology* / Q000302:isolation & purification / Q000494:pharmacology; D016676:Macrophages, Alveolar / Q000276:immunology* / Q000382:microbiology; D017737:Macrophages, Peritoneal / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D008297:Male; D010100:Oxygen / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000254:growth & development / Q000276:immunology
D023181:Antimicrobial Cationic Peptides; D001426:Bacterial Proteins; D037102:Lectins; D009195:Peroxidase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D010100:Oxygen