title: The importance of haplotype length and heritability using genomic selection in dairy cattle.
abstract: Reliabilities for genomic estimated breeding values (GEBV) were investigated by simulation for a typical dairy cattle breeding setting. Scenarios were simulated with different heritabilites (h2) and for different haplotype sizes, and seven generations with only genotypes were generated to investigate reliability of GEBV over time. A genome with 5000 single nucleotide polymorphisms (SNP) at distances of 0.1 cM and 50 quantitative trait loci (QTL) was simulated, and a Bayesian variable selection model was implemented to predict GEBV. Highest reliabilities were obtained for 10 SNP haplotypes. At optimal haplotype size, reliabilities in generation 1 without phenotypes ranged from 0.80 for h2 = 0.02 to 0.93 for h2 = 0.30, and in the seventh generation without phenotypes ranged from 0.69 for h2 = 0.02 to 0.86 for h2 = 0.30. Reliabilities of GEBV were found sufficiently high to implement dairy selection schemes without progeny testing in which case a data time-lag of two to three generations may be present. Reliabilities were also relatively high for low heritable traits, implying that genomic selection could be especially beneficial to improve the selection on, e.g. health and fertility.
authors.affiliation: Faculty of Agricultural Sciences, Department of Genetics & Biotechnology, University of Aarhus, Research Centre Foulum, Tjele, Denmark.
authors.forename: T M
authors.initials: TM
authors.lastname: Villumsen
authors.forename: L
authors.initials: L
authors.lastname: Janss
authors.forename: M S
authors.initials: MS
authors.lastname: Lund
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D001947:Breeding / Q000379:methods*; D002417:Cattle / Q000235:genetics*; D003198:Computer Simulation; D005260:Female; D023281:Genomics / Q000379:methods; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019655:Quantitative Trait, Heritable; D012641:Selection, Genetic