title: Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.
abstract: Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.
authors.affiliation: Department of Hematology, Oncology, and Transfusion Medicine, Campus Benjamin Franklin, Charité Universitätsmedizin Berlin, Germany. gero.huetter@charite.de
authors.forename: Gero
authors.initials: G
authors.lastname: Hütter
authors.forename: Daniel
authors.initials: D
authors.lastname: Nowak
authors.forename: Maximilian
authors.initials: M
authors.lastname: Mossner
authors.forename: Susanne
authors.initials: S
authors.lastname: Ganepola
authors.forename: Arne
authors.initials: A
authors.lastname: Müssig
authors.forename: Kristina
authors.initials: K
authors.lastname: Allers
authors.forename: Thomas
authors.initials: T
authors.lastname: Schneider
authors.forename: Jörg
authors.initials: J
authors.lastname: Hofmann
authors.forename: Claudia
authors.initials: C
authors.lastname: Kücherer
authors.forename: Olga
authors.initials: O
authors.lastname: Blau
authors.forename: Igor W
authors.initials: IW
authors.lastname: Blau
authors.forename: Wolf K
authors.initials: WK
authors.lastname: Hofmann
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thiel
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D015704:CD4 Antigens; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004279:DNA, Viral / Q000097:blood; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics; D006720:Homozygote; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000097:blood; D019713:Receptors, CCR5 / Q000235:genetics*; D033581:Stem Cell Transplantation; D018183:Transplantation Chimera; D014184:Transplantation, Homologous; D019562:Viral Load
chemical_list: D044966:Anti-Retroviral Agents; D015704:CD4 Antigens; D004279:DNA, Viral; D012367:RNA, Viral; D019713:Receptors, CCR5