Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients.
OBJECTIVE
Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil.


METHODS
Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe(1), ProRe(2)), with the same sedation targets.


RESULTS
With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe(1): respectively, 3.3 +/- 3.0 versus 8.9 +/- 6.1 and 7.47 +/- 5.05 versus 16.3 +/- 11.4 min. During SevAn the PaCO(2) and minute ventilation increased. Hemodynamics was stable between ProRe(1) and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits.


CONCLUSIONS
Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions.
Migliari
Maurizio
M
Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza (MI), Italy.
Bellani
Giacomo
G
Rona
Roberto
R
Isgrò
Stefano
S
Vergnano
Beatrice
B
Mauri
Tommaso
T
Patroniti
Nicolò
N
Pesenti
Antonio
A
Foti
Giuseppe
G
D000280:Administration, Inhalation; D000368:Aged; D000776:Anesthesiology / Q000295:instrumentation*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D016638:Critical Illness; D018592:Cross-Over Studies; D054810:Deep Sedation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D011446:Prospective Studies; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane