Why we should put clothes on mice.
Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.
Lodhi
Irfan J
IJ
Division of Endocrinology, Metabolism, and Lipid Research, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Semenkovich
Clay F
CF
D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D003920:Diabetes Mellitus / Q000517:prevention & control; D004734:Energy Metabolism; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D024101:Mitochondrial Proteins / Q000235:genetics*; D009765:Obesity / Q000517:prevention & control; D011943:Receptors, Adrenergic, beta / Q000172:deficiency; D013696:Temperature; D022722:Thermogenesis; D000071256:Uncoupling Protein 1
D007473:Ion Channels; D024101:Mitochondrial Proteins; D011943:Receptors, Adrenergic, beta; C000604371:UCP1 protein, human; C000604372:Ucp1 protein, mouse; D000071256:Uncoupling Protein 1