Dose related effect of systemic antibiotics in prevention of postoperative intra-abdominal adhesion formation in experimental animals.
Sixty hamsters weighing 100-120 g were randomly assigned to 2 equal groups. GI was injected intramuscularly with saline, half an hour preoperatively as control, and GII was injected with 50 mg/kg Cefepime HCI & 7.5 mg/kg Metronidazole. After a midline lapparotomy, abdominal adhesions were induced in GI & GII. Post-operration, animals in GI was divided according to the numbers of intramuscular saline injections into 2 subgroups. GIa (15) in which animals were injected every 12 hours for 2 doses and GIb (15) where animals were injected every 12 hours for 5 days. Similarly, the antibiotic group was subdivided into GIIa (15) and GIIb (15). On the 14th day, the hamsters were sacrificed and the adhesion score was determined. The 5 day antibiotics course revealed significant reduction in incidence (P < 0.01), extent (P < 0.001) and severity (P < 0.01) of the postoperative peritoneal adhesions, while the short course failed.
Abbas
Mohamad
M
Department of General Surgery, Theodor Bilharz Research Institute, Imbaba 12411, PO Box 30, Giza, Egypt.
Nafeh
Ayman E
AE
Elsebae
Magdy
M
Farouk
Youssef
Y
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000077723:Cefepime; D002511:Cephalosporins / Q000494:pharmacology*; D006224:Cricetinae; D004195:Disease Models, Animal; D007273:Injections, Intramuscular; D007813:Laparotomy / Q000009:adverse effects / Q000379:methods; D008647:Mesocricetus; D008795:Metronidazole / Q000494:pharmacology*; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D011897:Random Allocation; D013997:Time Factors; D000267:Tissue Adhesions / Q000453:epidemiology / Q000517:prevention & control*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D008795:Metronidazole; D000077723:Cefepime