Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies.
We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole.
Valentini
C G
CG
Candoni
A
A
Fianchi
L
L
Posteraro
B
B
Simeone
E
E
Costa
F
F
Sanguinetti
M
M
Voso
M T
MT
Caira
M
M
Fanin
R
R
Pagano
L
L
D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D020096:Zygomycosis / Q000188:drug therapy* / Q000601:surgery*
D000935:Antifungal Agents; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B