Digoxin blocks tumor growth through HIF-1alpha inhibition.
Lewis
Jana A
JA
Departments of Pharmacology and Chemistry, Vanderbilt University, Vanderbilt University Medical Center, Nashville, TN 37232-6600, USA.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004077:Digoxin / Q000627:therapeutic use*; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D004077:Digoxin