Targeting exofacial protein thiols with Gd(III) complexes. An efficient procedure for MRI cell labelling.
Cells display on the outer surface of the plasma membrane a large number of protein thiols that can be reversibly labelled with suitably designed Gd(III)-based contrast agents for cell tracking by MRI.
Digilio
Giuseppe
G
Department of Environmental and Life Sciences, University of Eastern Piedmont "A. Avogadro", Via Bellni 25G, 15100 Alessandria, Italy. giuseppe.digilio@mfn.unipmn.it
Catanzaro
Valeria
V
Fedeli
Franco
F
Gianolio
Eliana
E
Menchise
Valeria
V
Napolitano
Roberta
R
Gringeri
Concetta
C
Aime
Silvio
S
D002462:Cell Membrane / Q000378:metabolism*; D022082:Cellular Structures / Q000737:chemistry; D003287:Contrast Media / Q000737:chemistry* / Q000378:metabolism; D005682:Gadolinium / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D046911:Macromolecular Substances; D008279:Magnetic Resonance Imaging / Q000379:methods; D015394:Molecular Structure; D011506:Proteins; D013194:Staining and Labeling / Q000379:methods*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D003287:Contrast Media; D046911:Macromolecular Substances; D011506:Proteins; D013438:Sulfhydryl Compounds; D005682:Gadolinium