title: Can temporal fluctuation in spatial wall shear stress gradient initiate a cerebral aneurysm? A proposed novel hemodynamic index, the gradient oscillatory number (GON).
abstract: We propose a new hemodynamic index for the initiation of a cerebral aneurysm, defined by the temporal fluctuations of tension/compression forces acting on endothelial cells. We employed a patient-specific geometry of a human internal carotid artery (ICA) with an aneurysm, and reconstructed the geometry of the ICA before aneurysm formation by artificially removing the aneurysm. We calculated the proposed hemodynamic index and five other hemodynamic indices (wall shear stress (WSS) at peak systole, time-averaged WSS, time-averaged spatial WSS gradient, oscillatory shear index (OSI), and potential aneurysm formation indicator (AFI)) for the geometry before aneurysm formation using a computational fluid dynamics technique. By comparing the distribution of each index at the location of aneurysm formation, we discussed the validity of each. The results showed that only the proposed hemodynamic index had a significant correlation with the location of aneurysm formation. Our findings suggest that the proposed index may be useful as a hemodynamic index for the initiation of cerebral aneurysms.
authors.affiliation: Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579 Sendai, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shimogonya
authors.forename: Takuji
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Imai
authors.forename: Noriaki
authors.initials: N
authors.lastname: Matsuki
authors.forename: Takami
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D006439:Hemodynamics; D006801:Humans; D002532:Intracranial Aneurysm / Q000209:etiology* / Q000503:physiopathology*; D013312:Stress, Physiological / Q000502:physiology*; D013997:Time Factors