Triacylglycerol metabolism in adipose tissue.
Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem. Understanding of adipocyte-specific TAG synthesis and hydrolysis is critical to the development of strategies to treat and prevent obesity and its closely associated diseases, for example, Type 2 diabetes, hypertension and atherosclerosis. In this review, we present an overview of the major enzymes in TAG synthesis and lipolysis, including the recent discovery of a novel adipocyte TAG hydrolase.
Ahmadian
Maryam
M
University of California, Department of Nutritional Sciences & Toxicology, Berkeley, CA 94720, USA, Tel.: +1 510 642 3978; ; mahmadia@berkeley.edu.
Duncan
Robin E
RE
Jaworski
Kathy
K
Sarkadi-Nagy
Eszter
E
Sul
Hei Sook
HS