Synthesis of pyrrolnitrin and related halogenated phenylpyrroles.
A general approach to halogenated arylpyrroles, including the antifungal natural product pyrrolnitrin, is described using newly synthesized halogenated pyrroles and 2,6-disubstituted nitrobenzenes or 2,6-disubstituted anilines.
Morrison
Matthew D
MD
Department of Chemistry, Queen's University, Kingston, Ontario, Canada K7L 3N6.
Hanthorn
Jason J
JJ
Pratt
Derek A
DA
D000814:Aniline Compounds / Q000737:chemistry; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009578:Nitrobenzenes / Q000737:chemistry; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D011764:Pyrrolnitrin / Q000138:chemical synthesis* / Q000737:chemistry
D000814:Aniline Compounds; D000935:Antifungal Agents; D006846:Hydrocarbons, Halogenated; D009578:Nitrobenzenes; D011758:Pyrroles; D011764:Pyrrolnitrin