Glia, adenosine, and sleep.
Sleep is regulated by a homeostatic process that has long been thought to involve adenosine (AD) originating from neurons. In this issue of Neuron, Halassa et al. present evidence that sleep homeostasis depends upon gliotransmission and associated accumulation of AD that dampens neuronal excitability.
Jones
Barbara E
BE
Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC, H3A 2B4, Canada. barbara.jones@mcgill.ca
D000241:Adenosine / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002450:Cell Communication / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D009457:Neuroglia / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism; D012890:Sleep / Q000502:physiology*
D018047:Receptors, Purinergic P1; D000255:Adenosine Triphosphate; D000241:Adenosine