Vascular reactivity in the experimental, simvastatin-treated diabetes with endothelial dysfunction.
BACKGROUND
The aim of this study was to evaluate the effect of simvastatin therapy on general characteristics of diabetes and vascular reactivity in the 14 week-old streptozotosin-diabetic rats.


METHODS
Twenty-four Sprague-Dawley male rats were divided into four groups as following: control, control-statin, diabetes and diabetes-statin.


RESULTS
We observed that hyperglycemia and weight-loss observed in diabetic rats were partially treated with simvastatin, but were still different from the control group. After thapsigargin, the endothel-mediated acetylcholine releasing responses were decreased; the releasing response in diabetes-statin group differed from the diabetic group.


CONCLUSIONS
Simvastatin treatment in diabetic rats, in addition to the treatment of diabetic dislipidemia, has also partially treated the endothel-mediated releasing response in diabetes. We observed that thapsigargin reduces the response of the aortic rings to the current substance (Fig. 5, Ref. 15).
Yalcin
Samet
S
Ankara Atatürk Teaching and Research Hospital, Department of General Surgery, Ankara, Turkey.
Köksoy
Cüneyt
C
Ergül
Emre
E
Demirel
Emine
E
Yalcin
Bülent
B
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D019821:Simvastatin / Q000494:pharmacology*; D019284:Thapsigargin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D008055:Lipids; D019284:Thapsigargin; D019821:Simvastatin; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases