title: The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments.
abstract: An unexpectedly prominent aspect of murine experimental autoimmune encephalomyelitis is pre-onset astrocyte reactivity. Further examination of this phenomenon in the spinal cord demonstrates that grey matter, as well as white matter astrocytes, change their morphology and cell density from the earliest disease manifestation. Comparison of the two compartments reveals that, whereas white matter changes are rostro-caudally consistent, grey matter reactivity is spatially restricted and of varying amplitude between spinal cord levels. These data strongly suggest that in neuroinflammation early, cross-compartmental recruitment of astrocytes occurs, but with different expression patterns.
authors.affiliation: Department of Biochemistry, La Trobe University, Bundoora 3086, Victoria, Australia.
authors.forename: Hong
authors.initials: H
authors.lastname: Pham
authors.forename: Anton A
authors.initials: AA
authors.lastname: Ramp
authors.forename: Nectarios
authors.initials: N
authors.lastname: Klonis
authors.forename: Sze Woei
authors.initials: SW
authors.lastname: Ng
authors.forename: Armelle
authors.initials: A
authors.lastname: Klopstein
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Ayers
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Orian
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*; D001923:Brain Chemistry / Q000276:immunology; D002417:Cattle; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein; D006801:Humans; D006984:Hypertrophy; D051379:Mice; D016688:Mice, Inbred NOD; D009413:Nerve Fibers, Myelinated / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000276:immunology; D013116:Spinal Cord / Q000737:chemistry / Q000166:cytology / Q000276:immunology / Q000473:pathology; D013552:Swine; D013997:Time Factors
chemical_list: D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; C528900:glial fibrillary astrocytic protein, mouse