iDQC anisotropy map imaging for tumor tissue characterization in vivo.
Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue.
Branca
Rosa T
RT
Center for Molecular and Biomolecular Imaging, Duke University, Durham, North Carolina 27710, USA. rtb9@duke.edu
Chen
Yuming M
YM
Mouraviev
Vladimir
V
Galiana
Gigi
G
Jenista
Elizabeth R
ER
Kumar
Challa
C
Leuschner
Carola
C
Warren
Warren S
WS
D000465:Algorithms; D000818:Animals; D016880:Anisotropy; D001943:Breast Neoplasms / Q000175:diagnosis*; D045744:Cell Line, Tumor; D003287:Contrast Media; D005260:Female; D005290:Ferric Compounds; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide