title: New and selective ryanodine receptor activators for insect control.
abstract: Diamide insecticides have emerged as one of the most promising new classes of insecticide chemistry owing to their excellent insecticidal efficacy and high margins of mammalian safety. Chlorantraniliprole and flubendiamide, the first two insecticides from this class, demonstrate exceptional activity across a broad range of pests in the order Lepidoptera. This chemistry has been confirmed to control insects via activation of ryanodine receptors which leads to uncontrolled calcium release in muscle. The high levels of mammalian safety are attributed to a strong selectivity for insect over mammalian receptors.
authors.affiliation: DuPont Crop Protection, Stine-Haskell Research Center, 1090 Elkton Road, Newark, DE 19711, USA. george.p.lahm@usa.dupont.com
authors.forename: George P
authors.initials: GP
authors.lastname: Lahm
authors.forename: Daniel
authors.initials: D
authors.lastname: Cordova
authors.forename: James D
authors.initials: JD
authors.lastname: Barry
mesh_terms: D000818:Animals; D001549:Benzamides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D007300:Insect Control; D007306:Insecticides / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D007915:Lepidoptera / Q000187:drug effects; D012433:Ryanodine / Q000737:chemistry; D019837:Ryanodine Receptor Calcium Release Channel / Q000737:chemistry* / Q000378:metabolism; D013450:Sulfones / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D062367:ortho-Aminobenzoates / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D005466:Fluorocarbons; D010797:Phthalimides
chemical_list: D001549:Benzamides; D007306:Insecticides; D012433:Ryanodine; D019837:Ryanodine Receptor Calcium Release Channel; D013450:Sulfones; D062367:ortho-Aminobenzoates; C517733:chlorantranilipole; C508762:flubendiamide; D005466:Fluorocarbons; D010797:Phthalimides