title: [Vaccination in patients with cirrhosis].
abstract: Patients with cirrhosis are immunocompromised and have an increased risk of infection, with a worse outcome. Some of those infections may be prevented by vaccination. Immunization can reduce the morbidity and mortality associated with cirrhosis. Immunizations against hepatitis A and B viruses, influenza and pneumococcus are recommended by the French Haute Autorité de Santé since 2007. Vaccination against hepatitis A is recommended in non-immunized cirrhotic patients. Vaccination against hepatitis B is recommended in every cirrhotic patient with no serological markers, and post-vaccinal antibodies titer should be checked. Annual influenza immunization can be done in cirrhotic patients, and pneumococcal polysaccharide vaccination should be repeated after 5 years. Few data regarding vaccination coverage are available, but studies suggest that immunization rates are too low in this population.
authors.affiliation: Université Paris Descartes, Faculté de Médecine, INSERM CIC BT 505, AP-HP, Groupe Hospitalier Cochin-Saint Vincent de Paul, CIC de Vaccinologie Cochin Pasteur, Pôle de Médecine, F-75679, Paris Cedex 14, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Loulergue
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
mesh_terms: D005355:Fibrosis / Q000453:epidemiology*; D006506:Hepatitis A / Q000453:epidemiology / Q000517:prevention & control; D022362:Hepatitis A Vaccines / Q000008:administration & dosage; D006509:Hepatitis B / Q000517:prevention & control; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006801:Humans; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D022362:Hepatitis A Vaccines; D017325:Hepatitis B Vaccines