The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions.
The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet cross-talk.
Del Principe
Domenico
D
Department of Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. delprin@uniroma2.it
Frega
Gianluca
G
Savini
Isabella
I
Catani
M Valeria
MV
Rossi
Antonello
A
Avigliano
Luciana
L
D000975:Antioxidants / Q000378:metabolism; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004579:Electron Transport; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D010084:Oxidation-Reduction; D015539:Platelet Activation; D017382:Reactive Oxygen Species / Q000097:blood; D015398:Signal Transduction; D013927:Thrombosis / Q000097:blood
D000975:Antioxidants; D017382:Reactive Oxygen Species