title: Osteosarcoma treatment: state of the art.
abstract: Osteosarcoma (OS) is a class of cancer originating from bone, mainly afflicting children or young adults. It is the second highest cause of cancer-related death in these age groups, mainly due to development of often fatal metastasis, usually in the lungs. Survival for these patients is poor despite the aggressive use of surgery, chemotherapy, and/or radiotherapy. Thus, new effective drugs and other forms of therapy are needed. This article reviews the biology and the state of the art management of OS. New experimental drugs and potential therapies targeting molecular pathways of OS are also discussed.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Melbourne, Melbourne, VIC, 3010, Australia.
authors.forename: Hang T
authors.initials: HT
authors.lastname: Ta
authors.forename: Crispin R
authors.initials: CR
authors.lastname: Dass
authors.forename: Peter F M
authors.initials: PF
authors.lastname: Choong
authors.forename: Dave E
authors.initials: DE
authors.lastname: Dunstan
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy*; D001842:Bone and Bones / Q000187:drug effects; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008495:Medical Oncology / Q000379:methods* / Q000639:trends; D008954:Models, Biological; D009367:Neoplasm Staging; D012516:Osteosarcoma / Q000453:epidemiology* / Q000473:pathology / Q000628:therapy*; D011878:Radiotherapy / Q000379:methods; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents