title: Short-term evaluation of sedation with sevoflurane administered by the anesthetic conserving device in critically ill patients.
abstract: OBJECTIVE
  Assessing feasibility and physiological effects of sedation with sevoflurane, administered with the anesthetic conserving device (AnaConDa), in comparison with propofol and remifentanil.
  
  
  METHODS
  Seventeen patients undergoing mechanical ventilation underwent sedation with sevoflurane delivered with AnaConDa (phase SevAn), preceded and followed by sedation with propofol and remifentanil (phases ProRe(1), ProRe(2)), with the same sedation targets.
  
  
  RESULTS
  With both strategies it was possible to achieve the sedation targets. Time required to sedate and awake patients was greater during SevAn than ProRe(1): respectively, 3.3 +/- 3.0 versus 8.9 +/- 6.1 and 7.47 +/- 5.05 versus 16.3 +/- 11.4 min. During SevAn the PaCO(2) and minute ventilation increased. Hemodynamics was stable between ProRe(1) and SevAn, except for an increase in heart rate in the SevAn phase. Environmental pollution from sevoflurane was within the safety limits.
  
  
  CONCLUSIONS
  Sevoflurane can be effectively and safely used for short-term sedation of ICU patients with stable hemodynamic conditions.
authors.affiliation: Department of Perioperative Medicine and Intensive Care, San Gerardo Hospital, Monza (MI), Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Migliari
authors.forename: Giacomo
authors.initials: G
authors.lastname: Bellani
authors.forename: Roberto
authors.initials: R
authors.lastname: Rona
authors.forename: Stefano
authors.initials: S
authors.lastname: Isgrò
authors.forename: Beatrice
authors.initials: B
authors.lastname: Vergnano
authors.forename: Tommaso
authors.initials: T
authors.lastname: Mauri
authors.forename: Nicolò
authors.initials: N
authors.lastname: Patroniti
authors.forename: Antonio
authors.initials: A
authors.lastname: Pesenti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Foti
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D000776:Anesthesiology / Q000295:instrumentation*; D018685:Anesthetics, Inhalation / Q000008:administration & dosage / Q000494:pharmacology*; D016638:Critical Illness; D018592:Cross-Over Studies; D054810:Deep Sedation / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D011446:Prospective Studies; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane