PtCl4-catalyzed cyclization reaction of beta-allenols in the presence of indoles.
The highly regioselective PtCl4-catalyzed reaction of indoles with beta-allenols in THF at room temperature afforded indole derivatives containing a six-membered ether ring at the 3-position in moderate isolated yields. On the basis of a D-labeling experiment, a mechanistic rationale was proposed.
Kong
Wangqing
W
Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University, Hangzhou 310027, Zhejiang, People's Republic of China.
Cui
Jie
J
Yu
Yihua
Y
Chen
Guofei
G
Fu
Chunling
C
Ma
Shengming
S
D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004988:Ethers, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D017671:Platinum Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D004988:Ethers, Cyclic; D007211:Indoles; D017671:Platinum Compounds; C030173:platinum chloride