title: Maintaining reduced viral fitness and CD4 response in HIV-infected patients with viremia receiving a boosted protease inhibitor.
abstract: When fully suppressive regimens are not available, incompletely suppressive regimens also provide immunologic benefits. In this study, with stable background therapy, human immunodeficiency virus (HIV)-infected patients who were randomized to receive atazanavir or boosted atazanavir, compared with those who continued boosted protease inhibitor therapy, maintained similar virologic and immunologic control, resistance-mutation patterns, and replication capacities with reduced use of lipid-lowering medication.
authors.affiliation: Division of Infectious Diseases and Geographic Medicine, Stanford University, Palo Alto, California 94305-5107, USA. pmgrant@stanford.edu
authors.forename: Philip
authors.initials: P
authors.lastname: Grant
authors.forename: Jonathan
authors.initials: J
authors.lastname: Taylor
authors.forename: Pat
authors.initials: P
authors.lastname: Cain
authors.forename: William
authors.initials: W
authors.lastname: Short
authors.forename: Joel
authors.initials: J
authors.lastname: Gallant
authors.forename: Charles
authors.initials: C
authors.lastname: Farthing
authors.forename: Gary
authors.initials: G
authors.lastname: Thal
authors.forename: Eoin
authors.initials: E
authors.lastname: Coakley
authors.forename: Andrew
authors.initials: A
authors.lastname: Zolopa
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000069446:Atazanavir Sulfate; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D024882:Drug Resistance, Viral; D005260:Female; D006678:HIV / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009842:Oligopeptides / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use; D014766:Viremia; D014779:Virus Replication
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D009842:Oligopeptides; D011725:Pyridines; D000069446:Atazanavir Sulfate