title: [Initial care of the severely burned patient].
abstract: The care of severely burned patient is still an interdisciplinary challenge. Despite improvements in the understanding of the pathophysiology of burn disease, mortality is high if more than 25 % of body surface area is burned. Mortality increases in the presence of inhalation injury. Initially, the burn trauma leads to a capillary leakage syndrome, resulting in severe hypovolemia. Therefore, adequate volume substitution is the primary therapy to prevent potential life-threatening hypovolemic shock.
authors.affiliation: Division of Perioperative Care and Emergency Medicine, University Medical Center Utrecht. w.f.buhre@umcutrecht.nl
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Buhre
authors.forename: Frank
authors.initials: F
authors.lastname: Wappler
mesh_terms: D000368:Aged; D001830:Body Surface Area; D002056:Burns / Q000150:complications / Q000453:epidemiology / Q000401:mortality / Q000628:therapy*; D002059:Burns, Inhalation / Q000628:therapy; D002196:Capillaries / Q000473:pathology / Q000503:physiopathology; D002648:Child; D005858:Germany / Q000453:epidemiology; D006801:Humans; D020896:Hypovolemia / Q000209:etiology; D017410:Practice Guidelines as Topic; D012769:Shock / Q000209:etiology / Q000517:prevention & control*; D012955:Societies, Medical; D016896:Treatment Outcome