Thermosensitive PEG-PCL-PEG hydrogel controlled drug delivery system: sol-gel-sol transition and in vitro drug release study.
In this article, biodegradable and low molecular weight poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) triblock copolymers were successfully synthesized. Aqueous solution of the obtained PECE copolymers underwent sol-gel-sol transition as temperature increased which was flowing sol at room temperature and then turned into nonflowing gel at body temperature. Sol-gel-sol phase transition behaviors of aqueous PECE solutions were studied using rheometry and test tube-inverting method, which were affected by many factors, including the heating/cooling procedure and different additives in copolymers aqueous solution. In vitro drug release behavior was studied using bovine serum albumin (BSA) and Vitamin B(12) (VB(12)) as model drugs, and the PECE hydrogel could protect BSA from acidic degradation for 1 week at least. Therefore, PECE hydrogel is believed to be promising for injectable in situ gel-forming controlled drug delivery system due to their great thermosensitivity and biodegradability.
Gong
Chang Yang
CY
State Key Laboratory of Biotherapy, West China Hospital, and School of Life Science, Sichuan University, Chengdu 610041, China.
Dong
Peng Wei
PW
Shi
Shuai
S
Fu
Shao Zhi
SZ
Yang
Jin Liang
JL
Guo
Gang
G
Zhao
Xia
X
Wei
Yu Quan
YQ
Qian
Zhi Yong
ZY
D000143:Acids / Q000737:chemistry; D002850:Chromatography, Gel; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D012212:Rheology; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000737:chemistry; D012965:Sodium Chloride / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000737:chemistry
D000143:Acids; D003692:Delayed-Action Preparations; D020100:Hydrogels; D011091:Polyesters; C502908:poly(ethylene glycol)-poly(caprolactone)-poly(ethylene glycol); D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D012965:Sodium Chloride; D014805:Vitamin B 12