title: Albendazole and mebendazole have low efficacy against Trichuristrichiura in school-age children in Kabale District, Uganda.
abstract: Three groups of Trichuris trichiura-infected school-age children were treated with one dose 400mg albendazole, 100mg mebendazole twice daily for 3 d, or 100mg mebendazole twice daily for 5 d. The albendazole study investigated cure and egg reduction rates and found that only 5 of 66 infected children were egg-negative 7 d post-treatment, giving a cure rate of 8% and a geometric mean egg reduction rate of 89%. However, at day 14 post-treatment, all children were again egg-positive with significantly higher egg counts than at day 7 (P<0.001). The two mebendazole studies aimed for the recovery of adult T. trichiura worms. After the 3 d course of mebendazole treatment, only four worms were recovered on days 3-5 after start of treatment from 2 of 34 infected children. With the 5 d course of mebendazole treatment, 10 of 21 infected children expelled a total of 27 worms. In the last case the first worm appeared on day 4 post-treatment, and the highest number of worms was recovered when the study ended at day 7. In conclusion, even with the longest treatment regimen and collecting stool samples over seven consecutive days, only very few worms were recovered. The results of this study suggest that alternative drugs and/or alternative regimens in current control programmes against T. trichiura need renewed attention.
authors.affiliation: DBL-Centre for Health Research and Development, Department of Disease Biology, Faculty of Life Sciences, University of Copenhagen, Thorvaldsensvej 57, DK-1871 Frederiksberg C, Denmark. aol@life.ku.dk
authors.forename: Annette
authors.initials: A
authors.lastname: Olsen
authors.forename: Harriet
authors.initials: H
authors.lastname: Namwanje
authors.forename: Peter
authors.initials: P
authors.lastname: Nejsum
authors.forename: Allan
authors.initials: A
authors.lastname: Roepstorff
authors.forename: Stig M
authors.initials: SM
authors.lastname: Thamsborg
mesh_terms: D000284:Administration, Oral; D015766:Albendazole / Q000008:administration & dosage*; D000818:Animals; D002648:Child; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005243:Feces / Q000469:parasitology*; D005260:Female; D006801:Humans; D008297:Male; D008463:Mebendazole / Q000008:administration & dosage*; D010270:Parasite Egg Count; D016896:Treatment Outcome; D014257:Trichuriasis / Q000188:drug therapy*; D014454:Uganda
chemical_list: D008463:Mebendazole; D015766:Albendazole