title: Dammarane-type triterpene glycosides from Oncoba manii active against methicillin-resistant Staphylococcus aureus.
abstract: Drug-resistant bacteria are becoming more prevalent both in the community and in hospitals. In a search for new antibiotic leads, we used a high-throughput natural products chemistry approach to isolate one new (1) and two known (2, 3) dammarane-type triterpenes with mass-limited material from the African plant Oncoba manii. The new compound was determined by spectroscopic methods to be 1beta,2alpha,3beta,20(R)-tetrahydroxydammar-24-ene 3-O-alpha-L-rhamnopyranosyl-(1 --> 2)-beta-D-glucopyranoside. Compounds 1 and 2 inhibited the growth of methicillin-resistant Staphylococcus aureus (MRSA).
authors.affiliation: Lead Discovery and Rapid Structure Elucidation Group, Sequoia Sciences, Inc., Saint Louis, Missouri 63114, USA.
authors.forename: Eliane
authors.initials: E
authors.lastname: Garo
authors.forename: Chia S
authors.initials: CS
authors.lastname: Hung
authors.forename: Russell B
authors.initials: RB
authors.lastname: Williams
authors.forename: Krista M
authors.initials: KM
authors.lastname: Olson
authors.forename: Jin-Feng
authors.initials: JF
authors.lastname: Hu
authors.forename: Stephanie M
authors.initials: SM
authors.lastname: Rice
authors.forename: Grayson W
authors.initials: GW
authors.lastname: Hough
authors.forename: Matt G
authors.initials: MG
authors.lastname: Goering
authors.forename: Mark
authors.initials: M
authors.lastname: O'Neil-Johnson
authors.forename: Gary R
authors.initials: GR
authors.lastname: Eldridge
authors.forename: Courtney M
authors.initials: CM
authors.lastname: Starks
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031308:Salicaceae / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology; D000097669:Dammaranes
chemical_list: D000900:Anti-Bacterial Agents; D004187:Disaccharides; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; D014640:Vancomycin; D000097669:Dammaranes; C543381:1beta,2alpha,3beta,20(R)-tetrahydroxydammar-24-ene 3-O-alpha-L-rhamnopyranosyl-(1-2)-beta-D-glucopyranoside