title: A facile synthesis and fungicidal activities of 2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-ones.
abstract: The aza-Wittig reactions of iminophosphorane 3 with aromatic isocyanates generated carbodiimides 4, which were reacted with alkylamines under mild conditions to give a series of 2-(alkylamino)-5,6-dimethylthieno[2,3-d]pyrimidin-4(3H)-ones 6 and 8 in satisfactory yield. Their structures were confirmed by (1)H NMR, EI-MS, IR and elementary analysis, and compound 8c was further analyzed by single-crystal X-ray diffraction. The preliminary bioassays indicated that these compounds showed excellent fungicidal activities against six kinds of fungi.
authors.affiliation: Department of Medicinal Chemistry, Yunyang Medical College, Shiyan 442000, China. huyangg111@yahoo.com.cn
authors.forename: Yang-Gen
authors.initials: YG
authors.lastname: Hu
authors.forename: Ai-Hua
authors.initials: AH
authors.lastname: Zheng
authors.forename: Xu-Zhi
authors.initials: XZ
authors.lastname: Ruan
authors.forename: Ming-Wu
authors.initials: MW
authors.lastname: Ding