[Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis].
The cytotoxic activity of L-asparaginases from Yersinia pseudotuberculosis and from Erwinia carotovora were investigated in vitro using several tumor cells lines: Jurkat and Molt-4 (human T-lymphoblastic leukemia), MCF-7 (human breast adenocarcinoma), LnCap (human prostate carcinoma), NGUK1 (rat Gasser node neurinoma). E. coli L-asparaginase produced by "Medak" (Germany) was used as a reference. The cell growth inhibition data indicate that Y. pseudotuberculosis L-asparaginase significantly inhibits growth of leukemic and solid tumor cells. These results allow us to conclude that this L-asparaginase can be used for the development of new preparations for the therapy of different types of tumors.
Abakumova
O Iu
OIu
Podobed
O V
OV
Borisova
A A
AA
Sidoruk
K V
KV
Aleksandrova
S S
SS
Omel'ianiuk
N M
NM
Pokrovskaia
M V
MV
Kondakova
L I
LI
Sokolov
N N
NN
D000970:Antineoplastic Agents / Q000494:pharmacology*; D001215:Asparaginase / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D016973:Pectobacterium carotovorum / Q000201:enzymology; D015011:Yersinia pseudotuberculosis / Q000201:enzymology*
D000970:Antineoplastic Agents; D001215:Asparaginase