Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: report of a case.
Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.
Miyagawa
Shigeru
S
Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
Matsumiya
Goro
G
Funatsu
Toshihiro
T
Yoshitatsu
Masao
M
Sekiya
Naozumi
N
Fukui
Shinya
S
Hoashi
Takaya
T
Hori
Masatsugu
M
Yoshikawa
Hideki
H
Kanakura
Yuzuru
Y
Ishikawa
Jun
J
Aozasa
Katsuyuki
K
Kawaguchi
Naomasa
N
Matsuura
Nariaki
N
Myoui
Akira
A
Matsuyama
Akifumi
A
Ezoe
Sachiko
S
Iida
Hidehiro
H
Matsuda
Hikaru
H
Sawa
Yoshiki
Y
D016026:Bone Marrow Transplantation; D009202:Cardiomyopathies / Q000601:surgery*; D018421:Cardiomyoplasty / Q000379:methods*; D017809:Fatal Outcome; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D032448:Myoblasts, Skeletal / Q000637:transplantation*; D017202:Myocardial Ischemia / Q000601:surgery*; D014182:Transplantation, Autologous