title: Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease.
abstract: Profound neuronal dysfunction in the entorhinal cortex contributes to early loss of short-term memory in Alzheimer's disease. Here we show broad neuroprotective effects of entorhinal brain-derived neurotrophic factor (BDNF) administration in several animal models of Alzheimer's disease, with extension of therapeutic benefits into the degenerating hippocampus. In amyloid-transgenic mice, BDNF gene delivery, when administered after disease onset, reverses synapse loss, partially normalizes aberrant gene expression, improves cell signaling and restores learning and memory. These outcomes occur independently of effects on amyloid plaque load. In aged rats, BDNF infusion reverses cognitive decline, improves age-related perturbations in gene expression and restores cell signaling. In adult rats and primates, BDNF prevents lesion-induced death of entorhinal cortical neurons. In aged primates, BDNF reverses neuronal atrophy and ameliorates age-related cognitive impairment. Collectively, these findings indicate that BDNF exerts substantial protective effects on crucial neuronal circuitry involved in Alzheimer's disease, acting through amyloid-independent mechanisms. BDNF therapeutic delivery merits exploration as a potential therapy for Alzheimer's disease.
authors.affiliation: Department of Neurosciences-0626, 9500 Gilman Drive, University of California-San Diego, La Jolla, California 92093, USA.
authors.forename: Alan H
authors.initials: AH
authors.lastname: Nagahara
authors.forename: David A
authors.initials: DA
authors.lastname: Merrill
authors.forename: Giovanni
authors.initials: G
authors.lastname: Coppola
authors.forename: Shingo
authors.initials: S
authors.lastname: Tsukada
authors.forename: Brock E
authors.initials: BE
authors.lastname: Schroeder
authors.forename: Gideon M
authors.initials: GM
authors.lastname: Shaked
authors.forename: Ling
authors.initials: L
authors.lastname: Wang
authors.forename: Armin
authors.initials: A
authors.lastname: Blesch
authors.forename: Albert
authors.initials: A
authors.lastname: Kim
authors.forename: James M
authors.initials: JM
authors.lastname: Conner
authors.forename: Edward
authors.initials: E
authors.lastname: Rockenstein
authors.forename: Moses V
authors.initials: MV
authors.lastname: Chao
authors.forename: Edward H
authors.initials: EH
authors.lastname: Koo
authors.forename: Daniel
authors.initials: D
authors.lastname: Geschwind
authors.forename: Eliezer
authors.initials: E
authors.lastname: Masliah
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Chiba
authors.forename: Mark H
authors.initials: MH
authors.lastname: Tuszynski
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000627:therapeutic use*; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D011323:Primates
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D018696:Neuroprotective Agents