title: Management of painful chronic pancreatitis with single-dose radiotherapy.
abstract: OBJECTIVE
  Some patients with chronic pancreatitis present recurrent flare-ups of pancreatitis and/or unrelenting pain. Current management is mostly limited to analgesics and surgery. We reasoned that anti-inflammatory radiotherapy, which has proven useful to alleviate other painful inflammatory painful disorders, might prove valuable for severely symptomatic patients with chronic pancreatitis.
  
  
  METHODS
  We prospectively studied the efficacy of single-dose anti-inflammatory radiotherapy in 15 consecutive patients with chronic pancreatitis who fulfilled the following criteria: either two flare-ups of pancreatitis in the previous 6 months and/or continuous pain for more than 3 months. Treatment consisted of a single radiation dose of 8 Gy to the pancreas. Exocrine function (fecal elastase), endocrine function (c peptide), quality of life (EuroQol questionnaire), and clinical outcome were assessed before and after radiation. Response was defined as no further pain or flare-ups of pancreatitis.
  
  
  RESULTS
  During follow-up (median: 39 months; range: 4-72 months), 12 patients had no further pain or flare-ups. One patient required a second radiation dose 1 year after the initial treatment, but he has remained well ever since (50 months). Two other patients did not respond to radiotherapy. After radiotherapy either exocrine or endocrine pancreatic function, or both, deteriorated in three patients. Patients who responded to treatment (13/15) gained 4-20 kg in body weight during follow-up (median 4 kg) and EuroQol improved significantly from 0.58 to 0.86 (P<0.001).
  
  
  CONCLUSIONS
  Radiotherapy for severe symptomatic chronic pancreatitis appears to be a useful and effective therapeutic choice that could potentially substitute for or delay surgery.
authors.affiliation: Digestive Disease Research Unit, Hospital Universitari Vall d'Hebron, Barcelona, Spain. lguarner@vhebron.net
authors.forename: Luisa
authors.initials: L
authors.lastname: Guarner
authors.forename: Begoña
authors.initials: B
authors.lastname: Navalpotro
authors.forename: Xavier
authors.initials: X
authors.lastname: Molero
authors.forename: Jordi
authors.initials: J
authors.lastname: Giralt
authors.forename: J-R
authors.initials: JR
authors.lastname: Malagelada
mesh_terms: D015746:Abdominal Pain / Q000209:etiology / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D050500:Pancreatitis, Chronic / Q000150:complications* / Q000473:pathology / Q000532:radiotherapy*; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D020127:Recovery of Function; D016896:Treatment Outcome