New potential targets to modulate neutrophil function in inflammation.
The importance of neutrophils in human disease such as rheumatoid arthritis, asthma, adult respiratory distress syndrome, and COPD has prompted the search for drugs capable to slow down neutrophil-dependent inflammation, without interference with innate immune responses. In this review, we summarize new potential drugs targets against neutrophils mediated inflammatory responses.
Burgos
R A
RA
Laboratory of Molecular Pharmacology, Institute of Pharmacology, Faculty of Veterinary Sciences, Universidad Austral de Chile, Casilla 567, Valdivia, Chile. rburgos1@uach.cl
Hidalgo
M A
MA
Figueroa
C D
CD
Conejeros
I
I
Hancke
J L
JL
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology*; D009504:Neutrophils / Q000187:drug effects* / Q000473:pathology*
D000893:Anti-Inflammatory Agents