title: The sulfated polysaccharide porphyran reduces apolipoprotein B100 secretion and lipid synthesis in HepG2 cells.
abstract: The physiological effect of porphyran, a sulfated polysaccharides from an edible red alga, was studied in human hepatoma HepG2 cells. Porphyran supplementation significantly decreased apolipoprotein B100 secretion, and the reduction was partly associated with suppression of cellular lipid synthesis in HepG2 cells. This is the first study to elucidate the mechanism of the hypolipidemic effect of porphyran.
authors.affiliation: Department of Applied Biochemistry and Food Science, Saga University, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Inoue
authors.forename: Naomi
authors.initials: N
authors.lastname: Yamano
authors.forename: Kotaro
authors.initials: K
authors.lastname: Sakata
authors.forename: Koji
authors.initials: K
authors.lastname: Nagao
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Hama
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Yanagita
mesh_terms: D000818:Animals; D053299:Apolipoprotein B-100 / Q000378:metabolism*; D002417:Cattle; D045744:Cell Line, Tumor; D002788:Cholesterol Esters / Q000096:biosynthesis; D006801:Humans; D008055:Lipids / Q000096:biosynthesis*; D012624:Seaweed / Q000737:chemistry; D012685:Sepharose / Q000031:analogs & derivatives* / Q000494:pharmacology; D013455:Sulfur / Q000737:chemistry*; D014280:Triglycerides / Q000096:biosynthesis
chemical_list: D053299:Apolipoprotein B-100; D002788:Cholesterol Esters; D008055:Lipids; D014280:Triglycerides; C038549:porphyran; D013455:Sulfur; D012685:Sepharose