title: [A case of Lambert-Eaton myasthenic syndrome with small cell lung cancer, treated with 3,4-diaminopyridine].
abstract: A 77-year-old man was admitted to our hospital with muscle weakness and shortness of breath. Chest CT showed a mass in the left upper lobe, and electromyography showed waxing phenomenon with high-frequency repetitive stimulation. We diagnosed Lambert-Eaton myasthenic syndrome accompanying small cell lung cancer. He was treated with carboplatin and etoposide, and concurrent thoracic irradiation. Although, the tumor size decreased, his myasthenic symptoms remained. He started taking 3,4-diaminopyridine and his muscle weakness improved dramatically, and he was eventually able to walk finally. In some cases, anti-tumor therapies cannot improve the myasthenic symptoms. In such cases, 3,4-diaminopyridine could improve the quality of life, and should be approved in Japan.
authors.affiliation: Department of Pulmonary Medicine, Fukushima Medical University.
authors.forename: Kumi
authors.initials: K
authors.lastname: Uekita
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishida
authors.forename: Satoko
authors.initials: S
authors.lastname: Sekine
authors.forename: Taeko
authors.initials: T
authors.lastname: Ishii
authors.forename: Suguru
authors.initials: S
authors.lastname: Sato
authors.forename: Aya
authors.initials: A
authors.lastname: Sugawara
authors.forename: Motoko
authors.initials: M
authors.lastname: Tachihara
authors.forename: Kana
authors.initials: K
authors.lastname: Watanabe
authors.forename: Kenya
authors.initials: K
authors.lastname: Kanazawa
authors.forename: Junpei
authors.initials: J
authors.lastname: Saito
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tanino
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Munakata
mesh_terms: D015761:4-Aminopyridine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000368:Aged; D000077770:Amifampridine; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000188:drug therapy* / Q000209:etiology*; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D026902:Potassium Channel Blockers / Q000627:therapeutic use*; D055752:Small Cell Lung Carcinoma / Q000150:complications*
chemical_list: D026902:Potassium Channel Blockers; D015761:4-Aminopyridine; D000077770:Amifampridine