title: Inhibition of intracranial glioma growth by endometrial regenerative cells.
abstract: Animal studies have demonstrated that selective tropism of mesenchymal stem cells (MSC) for glioma may be used as a means of selective delivery of cytotoxic payloads. Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like cells which possesse pluripotent differentiation capacity and is characterized by unique surface markers and growth factor production. In this study we sought to determine whether unmanipulated ERC would alter the growth of glioma using the aggressive C6/LacZ7 (C6) into Sprague Dawley rat model. ERC administration by intravenous (i.v.) or intratumoral (i.t.) showed significant inhibition of glioma: volume reduction of 49% after i.v. treatment (p < 0.05), and about 46% i.t. treatment (p < 0.05). Tumor reduction was associated with inhibition of angiogenesis and reduced numbers of CD133 positive cells in the incranial tumor. Despite the angiogenic potential of ERC in the hindlimb ischemia model, these data support a paradoxical tumor inhibitory activity of ERC. Further studies are needed to determine the qualitative differences between physiological angiogenesis, which seems to be supported by ERC and tumor angiogenesis which appeared to be inhibited.
authors.affiliation: Bio-Communications Research Institute, Wichita, Kansas, USA.
authors.forename: Xiaodi
authors.initials: X
authors.lastname: Han
authors.forename: Xiaolong
authors.initials: X
authors.lastname: Meng
authors.forename: Zhenglian
authors.initials: Z
authors.lastname: Yin
authors.forename: Andrea
authors.initials: A
authors.lastname: Rogers
authors.forename: Jie
authors.initials: J
authors.lastname: Zhong
authors.forename: Paul
authors.initials: P
authors.lastname: Rillema
authors.forename: James A
authors.initials: JA
authors.lastname: Jackson
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Ichim
authors.forename: Boris
authors.initials: B
authors.lastname: Minev
authors.forename: Ewa
authors.initials: E
authors.lastname: Carrier
authors.forename: Amit N
authors.initials: AN
authors.lastname: Patel
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Min
authors.forename: Neil H
authors.initials: NH
authors.lastname: Riordan
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D004717:Endometrium / Q000166:cytology / Q000502:physiology; D005260:Female; D005910:Glioma / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D000090204:Mesothelin; D009368:Neoplasm Transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology*
chemical_list: D015703:Antigens, CD; C000715529:Msln protein, rat; D000090204:Mesothelin