Structure of the thioredoxin-fold domain of human phosducin-like protein 2.
Human phosducin-like protein 2 (hPDCL2) has been identified as belonging to subgroup II of the phosducin (Pdc) family. The members of this family share an N-terminal helix domain and a C-terminal thioredoxin-fold (Trx-fold) domain. The X-ray crystal structure of the Trx-fold domain of hPDCL2 was solved at 2.70 A resolution and resembled the Trx-fold domain of rat phosducin. Comparative structural analysis revealed the structural basis of their putative functional divergence.
Lou
Xiaochu
X
Institute of Protein Research, Tongji University, Shanghai 200092, People's Republic of China.
Bao
Rui
R
Zhou
Cong Zhao
CZ
Chen
Yuxing
Y
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006801:Humans; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D017510:Protein Folding; D017434:Protein Structure, Tertiary; D051381:Rats; D013879:Thioredoxins / Q000737:chemistry*
D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; C498321:PDCL2 protein, human; D013879:Thioredoxins