Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis.
Classical complement pathway factor, C4 is required for experimental autoimmune myasthenia gravis (EAMG) pathogenesis. C4 is also a central component of the mannose binding lectin (MBL) pathway suggesting that this pathway might also be involved in MG pathogenesis. However, MBL gene deficient mice displayed intact anti-acetylcholine receptor (AChR)-immune response and neuromuscular junction (NMJ) IgG and complement accumulation following AChR-immunization. Moreover, no significant difference was observed between the serum MBL levels of 77 anti-AChR antibody positive generalized MG patients and 105 healthy controls. Therefore, MBL pathway does not play a role in EAMG/MG pathogenesis.
Li
Jing
J
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555-1070, USA.
Qi
Huibin
H
Tüzün
Erdem
E
Allman
Windy
W
Yilmaz
Vuslat
V
Saini
Shamsher S
SS
Deymeer
Feza
F
Saruhan-Direskeneli
Güher
G
Christadoss
Premkumar
P
D000328:Adult; D000368:Aged; D000818:Animals; D037582:Complement Pathway, Mannose-Binding Lectin / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D014101:Torpedo
D007074:Immunoglobulin G; D037601:Mannose-Binding Lectin; D011950:Receptors, Cholinergic