title: 3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.
abstract: A series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared and found to show excellent binding affinities towards CXCR2 receptor.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
authors.forename: Purakkattle
authors.initials: P
authors.lastname: Biju
authors.forename: Arthur G
authors.initials: AG
authors.lastname: Taveras
authors.forename: Younong
authors.initials: Y
authors.lastname: Yu
authors.forename: Junying
authors.initials: J
authors.lastname: Zheng
authors.forename: R William
authors.initials: RW
authors.lastname: Hipkin
authors.forename: James
authors.initials: J
authors.lastname: Fossetta
authors.forename: Xuedong
authors.initials: X
authors.lastname: Fan
authors.forename: Jay
authors.initials: J
authors.lastname: Fine
authors.forename: Daniel
authors.initials: D
authors.lastname: Lundell
mesh_terms: D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D003959:Diamines; D023063:Receptors, Interleukin-8B; D013830:Thiadiazoles