Sc(OTf)3-catalyzed direct alkylation of quinolines and pyridines with alkanes.
The Sc(OTf)(3)-catalyzed C-C bond formation by direct alkylation of quinolines and pyridines using simple alkanes was developed. Various alkanes reacted with quinolines and pyridines to give the corresponding alkylation products in 50-91% yields in the presence of tert-butyl peroxide.
Deng
Guojun
G
Department of Chemistry, McGill University, 801 Sherbrooke Street West, Montreal, Quebec, Canada H3A 2K6.
Li
Chao-Jun
CJ