title: The underrecognized epilepsy spectrum: the effects of levetiracetam on neuropsychological functioning in relation to subclinical spike production.
abstract: The purpose of this prospective, open-label pilot study was to determine whether treatment with levetiracetam improves neuropsychological functioning in children and adolescents who have evidence of subclinical spike production associated with attention and learning difficulties. Six participants (mean age 9.8 years) were treated with levetiracetam up to 40 mg/kg per day and evaluated using neuropsychological (Wide Range Assessment of Memory and Learning, Second Edition), academic (Wechsler Individual Achievement Test, Second Edition, Abbreviated), and electroencephalographic assessments at baseline and after 10 weeks of treatment. Statistically significant improvements on indexes of the Wide Range Assessment of Memory and Learning, Second Edition were observed in 4 participants after 10 weeks. No statistically significant differences were observed for the Wechsler Individual Achievement Test, Second Edition, Abbreviated. Concomitant spike suppression was observed. Levetiracetam was generally well tolerated. A subset of patients exists with attention and learning problems that have associated aberrant cortical electrical activity without clinical seizures and associated neuropsychological deficits that may improve after treatment with levetiracetam.
authors.affiliation: Clinical Research Center of New Jersey and The Center for Neurological and Neurodevelopmental Health, Voorhees, New Jersey 08043, USA. MMintz@thecnnh.org
authors.forename: Mark
authors.initials: M
authors.lastname: Mintz
authors.forename: Daniel
authors.initials: D
authors.lastname: Legoff
authors.forename: Jean
authors.initials: J
authors.lastname: Scornaienchi
authors.forename: Micah
authors.initials: M
authors.lastname: Brown
authors.forename: Sarah
authors.initials: S
authors.lastname: Levin-Allen
authors.forename: Pnina
authors.initials: P
authors.lastname: Mintz
authors.forename: Cathy
authors.initials: C
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D001288:Attention / Q000187:drug effects; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000188:drug therapy* / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000188:drug therapy* / Q000503:physiopathology; D000077287:Levetiracetam; D008297:Male; D008568:Memory / Q000187:drug effects; D009483:Neuropsychological Tests; D010865:Pilot Projects; D010889:Piracetam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D000077287:Levetiracetam; D010889:Piracetam