title: Posterior capsule opacification in silicone and hydrophobic acrylic intraocular lenses with sharp-edge optics six years after surgery.
abstract: OBJECTIVE
  To compare posterior capsule opacification (PCO) between 2 three-piece intraocular lenses (IOLs) both with sharp-optic edges and open loop haptics, one made of silicone and the other made of hydrophobic acrylate, 6 years after surgery.
  
  
  METHODS
  Randomized, controlled, patient- and examiner-masked trial with intra-patient comparison.
  
  
  METHODS
  One hundred and six eyes in 53 patients were included initially. Forty-four eyes of 22 patients with age-related bilateral cataract were available for the 6 years follow-up. Each patient had standard cataract surgery and randomly received a silicone (CeeOn 911A; AMO, Santa Ana, California, USA) or hydrophobic acrylic (AcrySof MA60BM; Alcon, Fort Worth, Texas, USA) IOL in the first eye, the other type of IOL in the fellow eye. Follow-up examinations were at 1, 3, and 6 years after surgery. The intensity of posterior capsule opacification (PCO) was assessed using digital retro-illuminated photos and the "automated quantification of after-cataract" (AQUA) software. Neodymium-yttrium-aluminum-garnet-laser capsulotomies (YAG-LC) performed were noted.
  
  
  RESULTS
  Six years after surgery, the AQUA scores were 2.3 +/- 1.4 for the silicone and 3.8 +/- 2.0 for the acrylic IOLs (P = .0016). The acrylic IOL eyes also had a significant increase in AQUA score from the 3-year to the 6-year follow-up. YAG-LC were performed in 2 silicone and 6 acrylic IOLs (P = .01).
  
  
  CONCLUSIONS
  An angulated three-piece hydrophobic acrylic IOL had more PCO 6 years after surgery than a silicone IOL of otherwise similar design. Apart from an optic material effect, differences in haptic design and the degree of optic edge sharpness may play a role.
authors.affiliation: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.
authors.forename: Lorenz
authors.initials: L
authors.lastname: Vock
authors.forename: Alja
authors.initials: A
authors.lastname: Crnej
authors.forename: Oliver
authors.initials: O
authors.lastname: Findl
authors.forename: Thomas
authors.initials: T
authors.lastname: Neumayer
authors.forename: Wolf
authors.initials: W
authors.lastname: Buehl
authors.forename: Stefan
authors.initials: S
authors.lastname: Sacu
authors.forename: Georg
authors.initials: G
authors.lastname: Rainer
authors.forename: Rupert
authors.initials: R
authors.lastname: Menapace
mesh_terms: D000180:Acrylic Resins / Q000009:adverse effects*; D000368:Aged; D002386:Cataract / Q000209:etiology*; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy; D053844:Lasers, Solid-State / Q000627:therapeutic use; D007903:Lens Capsule, Crystalline / Q000473:pathology* / Q000601:surgery; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D018918:Phacoemulsification; D011474:Prosthesis Design; D012826:Silicone Elastomers / Q000009:adverse effects*; D014792:Visual Acuity
chemical_list: D000180:Acrylic Resins; D012826:Silicone Elastomers