Antioxidant and pro-oxidant capacities of ITCs.
Isothiocyanates (ITCs) are breakdown products of glucosinolates contained in cruciciferous vegetables. This heterogeneous family of molecules has the -N=C=S group as its common structural feature and possesses important cytoprotective properties. Their biological interactions are strongly related to modulation of cellular redox status, and a number of studies have documented their indirect antioxidant properties, particularly related to induction of phase-2 enzymes. On the other hand, some direct antioxidant behavior has also been observed for a limited number of ITCs. Paradoxically relevant pro-oxidant properties have also been documented, possibly related to the simultaneous induction of phase-1 enzymes. In this review, we will summarize and discuss the prevailing mechanisms for the antioxidant and pro-oxidant activity of ITCs, both in vivo and in vitro.
Valgimigli
Luca
L
Department of Organic Chemistry A. Mangini, Faculty of Pharmacy, University of Bologna, Bologna, Italy. luca.valgimigli@unibo.it
Iori
Renato
R
D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D019607:Brassicaceae / Q000737:chemistry; D002460:Cell Line; D006801:Humans; D017879:Isothiocyanates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000528:radiation effects; D015394:Molecular Structure; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
D000975:Antioxidants; D017879:Isothiocyanates