Lux vs. wavelength in light treatment of Seasonal Affective Disorder.
OBJECTIVE
Published dosing guidelines for treatment of Seasonal Affective Disorder (SAD) refer to photopic lux, which is not appropriate for short-wavelength light. Short wavelengths are most potent for many non-visual responses to light. If SAD therapy were similarly mediated, standards utilizing lux risk overestimating necessary dose. We investigated antidepressant responses to light using two light-emitting diode (LED) sources, each emitting substantial short-wavelength light, but <2500 lux.


METHODS
A randomized, double-blind trial investigated 3-week 45 min/day out-patient treatment with blue-appearing (goLITE) or blue-enriched white-appearing light in 18 moderately-depressed adults (12F, 49.1 +/- 9.5 years). Equivalent numbers of photons within the short-wavelength range were emitted, but the white source emitted twice as many photons overall and seven-fold more lux.


RESULTS
Depression ratings (SIGH-ADS; http://www.cet.org) decrease averaged 82% (SD = 17%) from baseline (P < 0.0001) in both white- and blue-light groups. Both sources were well tolerated.


CONCLUSIONS
Short-wavelength LED light sources may be effective in SAD treatment at fewer lux than traditional fluorescent sources.
Anderson
J L
JL
Department of Psychiatry, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA. jlanderson@partners.org
Glod
C A
CA
Dai
J
J
Cao
Y
Y
Lockley
S W
SW
D000293:Adolescent; D000328:Adult; D002940:Circadian Rhythm; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017785:Photons; D010789:Phototherapy / Q000379:methods*; D016574:Seasonal Affective Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D055815:Young Adult