[Estimation of liver inflammation and necrosis in patients with chronic hepatitis B through different biochemical items].
OBJECTIVE
To establish a new grading system to evaluate liver inflammation and necrosis in patients with chronic hepatitis B through clinical biochemical assays.


METHODS
Clinical and pathological data were collected from 255 cases with chronic hepatitis B. 19 biochemical items were analyzed and 5 items were selected for our grading system. Each of the five items was scored 0 to 4 based on the different values. The extent of liver inflammation and necrosis was evaluated according to the total score.


RESULTS
ALT, AST, ChE, GGT and TBA were selected for our grading system. The grade of liver inflammation and necrosis was considered less than 2.0 if total score lower than 6, and higher grade was considered with higher total score. The estimated results shared an identity of 82.8% with the real grades of liver inflammation and necrosis. When this grading system was applied to patients with liver inflammation and necrosis equal to or higher than grade 2.0, it exhibited a sensitivity of 83.8%, a specificity of 81.2%, a positive prediction value of 88.6%, a negative prediction value of 74.2% in all cases, and 88.0%, 84.7%, 90.6%, 82.4% respectively in patients older than 12 years.


CONCLUSIONS
Our data suggest that the grading system can be used to evaluate the extent of liver inflammation and necrosis in patients with chronic hepatitis B.
Shen
Hong-Hui
HH
Institute of Infectious Diseases, Beijing 302 Hospital, Beijing 100039, China.
Zhao
Jing-Min
JM
Xin
Shao-Jie
SJ
D000293:Adolescent; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood; D015415:Biomarkers / Q000097:blood*; D001707:Biopsy, Needle / Q000379:methods; D002802:Cholinesterases / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood* / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000473:pathology*; D008111:Liver Function Tests; D008297:Male; D009336:Necrosis; D012720:Severity of Illness Index; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
D001647:Bile Acids and Salts; D015415:Biomarkers; D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002802:Cholinesterases