title: Epithelioid osteosarcoma of the jaw.
abstract: Epithelioid osteosarcoma (OS) is a rare sub-type of OS with an aggressive behavior. An epithelioid OS was diagnosed in an 8-year-old female with painful swelling of the left jaw. After two courses of chemotherapy (cisplatin/methotrexate/doxorubicin), the patient presented a progressive disease. After hemimandibulectomy, 13 courses of post-operative chemotherapy (cisplatin/methotrexate/doxorubicin/ifosfamide) were performed. Histological and ultra-structural examination showed a high grade neoplasm consisting of sheets of epithelioid cells with focal osteoid formation. The patient is alive and in complete remission 42 months from diagnosis.
authors.affiliation: Division of Oncology, Ospedale Pediatrico Bambino Gesù, Rome, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Cozza
authors.forename: Rita
authors.initials: R
authors.lastname: Devito
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: De Ioris
authors.forename: Mario
authors.initials: M
authors.lastname: Zama
authors.forename: Renata
authors.initials: R
authors.lastname: Boldrini
authors.forename: Paola
authors.initials: P
authors.lastname: Fidani
authors.forename: Alberto
authors.initials: A
authors.lastname: Donfrancesco
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D015622:Epithelioid Cells / Q000473:pathology*; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D007573:Jaw Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D008727:Methotrexate / Q000008:administration & dosage; D012516:Osteosarcoma / Q000175:diagnosis* / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D004317:Doxorubicin; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate