title: Multi-informant ratings of psychiatric symptom severity in children with autism spectrum disorders: the importance of environmental context.
abstract: The present study examines co-occurring psychiatric syndromes in a well-characterized sample of youths with autism spectrum disorders (ASD; n = 177) and their siblings (n = 148), reported independently by parents and teachers. In ASD, parents reported substantial comorbidity with affective (26%), anxiety (25%), attentional (25%), conduct (16%), oppositional (15%), and somatic problems (6%). Teachers reported a much lower prevalence. Autistic severity scores for children with ASD exhibited moderate correlations with general psychopathology within- but not across-informants, whereas, sibling correlations were significant both within- and across-informants. Results support the role of environmental context in psychiatric symptom expression in children affected by autism and suggest that informant discrepancies may more provide critical cues for these children via specific environmental modifications.
authors.affiliation: Department of Health Psychology and Thompson Center for Autism and Neurodevelopmental Disorders, University of Missouri, 300 Portland Street, Columbia, MO 65211, USA. kannest@health.missouri.edu
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Kanne
authors.forename: Anna M
authors.initials: AM
authors.lastname: Abbacchi
authors.forename: John N
authors.initials: JN
authors.lastname: Constantino
mesh_terms: D000293:Adolescent; D001007:Anxiety / Q000453:epidemiology* / Q000523:psychology; D020817:Asperger Syndrome / Q000453:epidemiology / Q000523:psychology*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000453:epidemiology* / Q000523:psychology; D001321:Autistic Disorder / Q000453:epidemiology / Q000523:psychology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008923:Missouri / Q000453:epidemiology; D019964:Mood Disorders / Q000453:epidemiology* / Q000523:psychology; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D012801:Sibling Relations; D035781:Siblings / Q000523:psychology; D012931:Social Environment; D011795:Surveys and Questionnaires