Association between ingestion of nonsteroidal anti-inflammatory drugs and the emergence of aphthous-like ulcers.
OBJECTIVE
To determine the relationship between aphthous-like ulcers and the ingestion of non-steroidal anti-inflammatory drugs.


METHODS
A total of 150 subjects were included in this study. The study group consisted of 75 subjects who presented with clinical signs of aphthous-like ulcers. The control group consisted of 75 subjects with no clinical signs or history of oral ulcers. All subjects were clinically examined and received a questionnaire which included a history of non-steroidal anti-inflammatory drugs intake.


RESULTS
The results of this study demonstrated a possible relationship between aphthous-like ulcers and non-steroidal anti-inflammatory drugs intake. There was a statistically significant increase in the prevalence of the ulcers in subjects taking NSAIDs (p <0.0001).


CONCLUSIONS
Physicians and dentists may need to investigate the use of non-steroidal anti-inflammatory drugs with patients diagnosed with aphthous-like ulcers and may require them to reduce or stop the use of these medications or change them to other types of medications, especially when other contributing factors are eliminated.
Hasan
AbdulAziz A
AA
Department of Preventive and Developmental Sciences, Kuwait University, Kuwait. aahasan@hsc.edu.kw
Ciancio
Sebastian
S
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013281:Stomatitis, Aphthous / Q000209:etiology*; D011795:Surveys and Questionnaires; D055815:Young Adult
D000894:Anti-Inflammatory Agents, Non-Steroidal