Hemophilia and cancer: a new challenge for hemophilia centers.
The improved life expectancy of hemophilia patients due to the advances in hemophilia care and factor replacement therapy has permitted to hemophiliacs to reach an older age. As a consequence, age-related diseases, such as cardiovascular disorders and cancer, have been increasingly recognized in such patients. In particular, the management of cancer in people with inherited hemorrhagic disorders represents a new challenge for physicians working in hemophilia centers. The few published literature data document that there is a close relationship between hemophilia and neoplasia. Indeed, the congenital bleeding tendency may influence the cancer in different ways, by interfering with its clinical presentation, diagnosis and treatment. These aspects, along with the epidemiology of cancer in hemophiliacs will be discussed in this review.
Franchini
Massimo
M
Immunohematology and Transfusion Center - Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy. massimo.franchini@azosp.vr.it
Lippi
Giuseppe
G
Montagnana
Martina
M
Targher
Giovanni
G
Zaffanello
Marco
M
Salvagno
Gian Luca
GL
Rivolta
Gianna Franca
GF
Perna
Caterina Di
CD
Tagliaferri
Annarita
A
D000328:Adult; D017677:Age Distribution; D015897:Comorbidity; D004359:Drug Therapy, Combination; D005260:Female; D006467:Hemophilia A / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D006782:Hospitals, Special; D006801:Humans; D015994:Incidence; D008136:Longevity; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000628:therapy; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis