Cerebral blood volume in Alzheimer's disease and correlation with tissue structural integrity.
A vascular component is increasingly recognized as important in Alzheimer's disease (AD). We measured cerebral blood volume (CBV) in patients with probable AD or Mild Cognitive Impairment (MCI) and in elderly non-demented subjects using a recently developed Vascular-Space-Occupancy (VASO) MRI technique. While both gray and white matters were examined, significant CBV deficit regions were primarily located in white matter, specifically in frontal and parietal lobes, in which CBV was reduced by 20% in the AD/MCI group. The regions with CBV deficit also showed reduced tissue structural integrity as indicated by increased apparent diffusion coefficients, whereas in regions without CBV deficits no such correlation was found. Subjects with lower CBV tended to have more white matter lesions in FLAIR MRI images and showed slower psychomotor speed. These data suggest that the vascular contribution in AD is primarily localized to frontal/parietal white matter and is associated with brain tissue integrity.
Uh
Jinsoo
J
Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States.
Lewis-Amezcua
Kelly
K
Martin-Cook
Kristin
K
Cheng
Yamei
Y
Weiner
Myron
M
Diaz-Arrastia
Ramon
R
Devous
Michael
M
Shen
Dinggang
D
Lu
Hanzhang
H
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology; D009483:Neuropsychological Tests; D009435:Synaptic Transmission / Q000502:physiology