title: Globus: are we any nearer to understanding it?
abstract: Globus is a common functional symptom without a clearly accepted etiology. Upper esophageal sphincter (UES) hypertension and gastroesophageal reflux have been proposed but not confirmed. Kwiatek et al. report a detailed study in globus patients using high-resolution manometry (HRM). The study showed greater respiratory augmentation of UES pressure compared with control groups among two-thirds of globus patients. Further prospective studies are needed to confirm these findings and to establish whether they are of etiologic significance.
authors.forename: Reshma
authors.initials: R
authors.lastname: Rakshit
authors.forename: John
authors.initials: J
authors.lastname: de Caestecker
mesh_terms: D049631:Esophageal Sphincter, Upper / Q000503:physiopathology*; D045853:Exhalation / Q000502:physiology*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000503:physiopathology; D006801:Humans; D001239:Inhalation / Q000502:physiology*; D008365:Manometry; D020886:Somatosensory Disorders / Q000209:etiology* / Q000503:physiopathology*