[Effects of gamma-aminobutyric acid on the Hering-Breuer inspiratory-inhibitory reflex].
In acute experiments on rats, effects of cerebro-ventricular microinjections of the gamma-aminobutyric acid (GABA) in the ventilation and Hering-Breuer inspiratory-inhibitory reflex were studied. Alteration of this reflex was estimated by changing in amplitude and duration of the esophageal pressure inspiratory oscillations after tracheal occlusion which was made at the moment of the end of expiration. It has been found that injection of 20 microM of GABA into the lateral ventricle produced a decrease of ventilation in result of diminished respiratory rate and tidal volume and weakening of the inspiratory muscle contractions. The GABA injection significantly decreased the respiratory response to occlusion and therefore it seems that GABA receptors take part in the Hering-Breuer inspiratory-inhibitory reflex.
Aleksandrova
N P
NP
Aleksandrov
V G
VG
Ivanova
T G
TG
D000818:Animals; D045853:Exhalation / Q000187:drug effects* / Q000502:physiology; D018682:GABA Agents / Q000494:pharmacology*; D001239:Inhalation / Q000187:drug effects* / Q000502:physiology; D020547:Lateral Ventricles / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D018682:GABA Agents; D005680:gamma-Aminobutyric Acid