Catalytic asymmetric intramolecular hydroarylations of omega-aryloxy- and arylamino-tethered alpha,beta-unsaturated aldehydes.
Economical approach: The first organocatalytic asymmetric intramolecular hydroarylation of phenol- and aniline-derived enals offers one of the most straightforward and atom-economic approaches to enantioriched chromans and tetrahydroquinolines (up to 96% ee; see scheme).
Lu
Hai-Hua
HH
Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 152 Luoyu Road, Wuhan, Hubei 430079, China.
Liu
Hui
H
Wu
Wei
W
Wang
Xu-Fan
XF
Lu
Liang-Qiu
LQ
Xiao
Wen-Jing
WJ
D000447:Aldehydes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D000814:Aniline Compounds; D002839:Chromans; D011804:Quinolines