Transient increase in cytokines and nerve growth factor in the rat dorsal root ganglia after nerve lesion and peripheral inflammation.
Inflammatory response occurs, in general, at the peripheral site of injury or irritation and in the corresponding spinal dorsal horn segments. In this study, we show transient increases in the protein concentrations of interleukins 1beta, 6, 8 and NGF in lumbar DRGs within hours after sciatic mononeuropathy in the rat. Comparable increases, with variation in temporal patterns, were observed after skin inflammation induced by intraplantar injection of endotoxin or complete Freund's adjuvant. The non-matching temporal profiles of cytokines and NGF increases and those of behavioral hypersensitivity, particularly peak values, suggest that the roles of these proteins are not necessarily pro-nociceptive in the DRGs at the chronic phase of neuropathy.
Saab
Carl Y
CY
Department of Surgery, Rhode Island Hospital, Brown Alpert Medical School, Department of Neuroscience, Brown University, Providence, RI 02903, USA.
Shamaa
Farah
F
El Sabban
Marwan E
ME
Safieh-Garabedian
Bared
B
Jabbur
Suhayl J
SJ
Saadé
Nayef E
NE
D000818:Animals; D016207:Cytokines / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D005727:Ganglia, Spinal / Q000276:immunology / Q000378:metabolism* / Q000473:pathology*; D006930:Hyperalgesia / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D020932:Nerve Growth Factor / Q000096:biosynthesis* / Q000502:physiology; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D020426:Sciatic Neuropathy / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D013997:Time Factors
D016207:Cytokines; D020932:Nerve Growth Factor