Simple and rapid colorimetric sensing of enzymatic cleavage and oxidative damage of single-stranded DNA with unmodified gold nanoparticles as indicator.
The sequence-length-dependent adsorption of single-stranded DNA (ssDNA) on unmodified gold nanoparticles is exploited as a new mechanism for colorimetric nuclease assay and measurement of oxidative DNA damage.
Shen
Qinpeng
Q
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, PR China.
Nie
Zhou
Z
Guo
Manli
M
Zhong
Chuan-Jian
CJ
Lin
Bin
B
Li
Wang
W
Yao
Shouzhuo
S
D000327:Adsorption; D003124:Colorimetry / Q000379:methods*; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D007202:Indicators and Reagents; D053768:Metal Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D013997:Time Factors
D004277:DNA, Single-Stranded; D007202:Indicators and Reagents; D006046:Gold