Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2.
The bactericidal activity of amoxicillin was investigated against Enterococcus faecalis JH2-2 and against an isogenic mutant deficient in the production of the N-acetylglucosaminidase AtlA. Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis.
Bravetti
Anne-Lise
AL
Faculté de Médecine Xavier Bichat, Université Paris 7, Paris, France.
Mesnage
Stéphane
S
Lefort
Agnès
A
Chau
Françoise
F
Eckert
Catherine
C
Garry
Louis
L
Arthur
Michel
M
Fantin
Bruno
B
D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects*; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000502:physiology*
D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D009238:N-Acetylmuramoyl-L-alanine Amidase