Biomimetic nanowire coatings for next generation adhesive drug delivery systems.
Without bioadhesive delivery devices, complex compounds are typically degraded or cleared from mucosal tissues by the mucous layer.While some chemically modified, microstructured surfaces have been studied in aqueous environments,adhesion due to geometry alone has not been investigated. Silicon nanowire-coated beads show significantly better adhesion than those with targeting agents under shear, and can increase the lift-off force 100-fold. We have shown that nanowire coatings, paired with epithelial physiology, significantly increase adhesion in mucosal conditions.
Fischer
Kathleen E
KE
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California 94158, USA. kayte@berkeley.edu
Alemán
Benjamin J
BJ
Tao
Sarah L
SL
Hugh Daniels
R
R
Li
Esther M
EM
Bünger
Mark D
MD
Nagaraj
Ganesh
G
Singh
Parminder
P
Zettl
Alex
A
Desai
Tejal A
TA
D040761:Biomimetic Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000295:instrumentation* / Q000639:trends*; D018625:Microscopy, Atomic Force; D008855:Microscopy, Electron, Scanning; D053770:Nanowires / Q000737:chemistry* / Q000648:ultrastructure
D004337:Drug Carriers