From DNA cross-linking to peptide labeling: on the versatility of the furan-oxidation-conjugation strategy.
Based on the incorporation of commercially available N-Fmoc-furylalanine, a new method for peptide labeling is proposed, relying on the selective oxidative transformation of the furan moiety into a reactive aldehyde and subsequent reductive amination.
Deceuninck
Annelies
A
Laboratory for Organic and Biomimetic Chemistry, Department of Organic Chemistry, Krijgslaan 281, S4; B-9000 Gent, Belgium.
Madder
Annemieke
A
D000447:Aldehydes / Q000737:chemistry; D000586:Amination; D000595:Amino Acid Sequence; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010455:Peptides / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D000447:Aldehydes; D003432:Cross-Linking Reagents; D005663:Furans; D010455:Peptides; D004247:DNA