title: Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis.
abstract: BACKGROUND
  Endotoxaemia is commonly seen in cirrhotic patients with ascites and this may be associated with increased portal pressure.
  
  
  OBJECTIVE
  To investigate the effect of intestinal decontamination on liver haemodynamics in alcohol-related cirrhotic patients with ascites.
  
  
  METHODS
  We included 30 patients. At day 0, systemic and splanchnic circulation endotoxin levels were determined and HVPG measurement performed. Patients received rifaximin (1200 mg/day) for 28 days. At day 29, systemic and splanchnic circulation endotoxin levels were determined and HVPG measurement performed again.
  
  
  RESULTS
  Median (range) plasma endotoxin levels decreased significantly after rifaximin administration both in systemic [1.45(0-3.1) vs. 0.7(0-2.7), P < 0.0001] and splanchnic circulation [1.8(0-3.4) vs. 0.8(0-2.1), P < 0.0001]. Meanwhile, the difference seen in endotoxin levels between the splanchnic and systemic circulation at day 0 (P = 0.001) was not noted at day 29 (P = 0.137). HVPG measurement was possible in 28 patients. Median (range) HVPG values were 18 mmHg (12.7-26.3) on day 0 vs. 14.7 mmHg (7-20) on day 29 (P < 0.0001). HVPG decreased after rifaximin in 23, remained stable in two and increased in three patients.
  
  
  CONCLUSIONS
  Hepatic venous pressure gradient values decreased significantly after intestinal decontamination with rifaximin in patients with alcohol-related decompensated cirrhosis and this might have been achieved through significant reduction of plasma endotoxin levels.
authors.affiliation: 2nd Department of Gastroenterology, Evangelismos Hospital, Athens, Greece. jvlachog@hotmail.com
authors.forename: J
authors.initials: J
authors.lastname: Vlachogiannakos
authors.forename: A S
authors.initials: AS
authors.lastname: Saveriadis
authors.forename: N
authors.initials: N
authors.lastname: Viazis
authors.forename: I
authors.initials: I
authors.lastname: Theodoropoulos
authors.forename: K
authors.initials: K
authors.lastname: Foudoulis
authors.forename: S
authors.initials: S
authors.lastname: Manolakopoulos
authors.forename: S
authors.initials: S
authors.lastname: Raptis
authors.forename: D G
authors.initials: DG
authors.lastname: Karamanolis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019973:Alcohol-Related Disorders; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001201:Ascites / Q000188:drug therapy; D004731:Endotoxins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008102:Liver Circulation / Q000187:drug effects*; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012294:Rifamycins / Q000008:administration & dosage*; D000078262:Rifaximin; D016896:Treatment Outcome; D014690:Venous Pressure / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D004731:Endotoxins; D012294:Rifamycins; D000078262:Rifaximin