Functions and regulatory mechanisms of Gq-signaling pathways.
Gq family members of heterotrimeric G protein activate beta isoforms of phospholipase C that hydrolyzes phosphatidylinositol phosphate to diacylglycerol and inositol trisphosphate, leading to the protein kinase C activation and intracellular Ca(2+) mobilization, respectively. To understand the functions and regulatory mechanisms of Gq-signaling pathways, we first introduce the Galphaq-interacting proteins, which function as the effectors and the modulators of Gq. Next, we describe the Pasteurella multocida toxin and YM-254890, which are useful tools to investigate Gq signaling as activator and inhibitor, respectively. Finally, we discuss the physiological function of Gq in developmental brain, especially in neural progenitor cells.
Mizuno
Norikazu
N
Department of Cell Biology, Graduate School of Biological Sciences, Nara Institute of Science and Technology, Takayama, Ikoma, Nara, Japan.
Itoh
Hiroshi
H
D000818:Animals; D001426:Bacterial Proteins / Q000633:toxicity; D001427:Bacterial Toxins / Q000633:toxicity; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D017173:Caenorhabditis elegans; D020555:GTP-Binding Protein Regulators / Q000378:metabolism; D043802:GTP-Binding Protein alpha Subunits, Gq-G11 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000378:metabolism; D010456:Peptides, Cyclic / Q000633:toxicity; D020836:Protein Structure, Quaternary; D015398:Signal Transduction / Q000187:drug effects; D013234:Stem Cells / Q000378:metabolism
D001426:Bacterial Proteins; D001427:Bacterial Toxins; D020555:GTP-Binding Protein Regulators; C062258:Pasteurella multocida toxin; D010456:Peptides, Cyclic; C475455:YM-254890; D043802:GTP-Binding Protein alpha Subunits, Gq-G11