title: Churg-Strauss syndrome associated with acalculous cholecystitis and liver involvement.
abstract: We describe a 65-year-old man who had liver involvement with Churg-Strauss syndrome. He was admitted to the hospital because of fever, weight loss, dyspnea, abdominal pain, skin lesions and paraesthesias. His past medical history revealed a diagnosis of acalculous cholecystitis that had been made eight months earlier. Microscopic examination of a gall bladder biopsy specimen obtained at that time revealed an increase in extravascular eosinophils. There was evidence of a new bilateral pulmonary disease with bronchoconstriction and a transient infiltrated lesion in the right upper lung. The patient's white cell count was 14 620 per cubic millimetre, with 39% eosinophils (5800 per cubic millimetre) and 39% neutrophils. IgE was 503 g/L (normal range, 0 to 100 g/L). Liver function tests were mildly elevated. Fine needle liver biopsy showed active interface hepatitis. A diagnosis of Churg-Strauss syndrome was made. In this patient the syndrome occurred in a rare association with hepatitis, likely due to immunologic events in the liver. The patient was successfully treated with 60 mg/day of prednisolone monotherapy.
authors.affiliation: Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. yukselilhami@hotmail.com
authors.forename: I
authors.initials: I
authors.lastname: Yüksel
authors.forename: H
authors.initials: H
authors.lastname: Ataseven
authors.forename: O
authors.initials: O
authors.lastname: Başar
authors.forename: S
authors.initials: S
authors.lastname: Köklü
authors.forename: I
authors.initials: I
authors.lastname: Ertuğrul
authors.forename: M
authors.initials: M
authors.lastname: Ibiş
authors.forename: T
authors.initials: T
authors.lastname: Temuçin
authors.forename: N
authors.initials: N
authors.lastname: Saşmaz
mesh_terms: D042101:Acalculous Cholecystitis / Q000150:complications*; D000368:Aged; D015267:Churg-Strauss Syndrome / Q000150:complications*; D006505:Hepatitis / Q000150:complications*; D006801:Humans; D008297:Male