title: Intermolecular methoxycarbonylation of terminal alkynes catalyzed by palladium(II) bis(oxazoline) complexes.
abstract: Boxing clever: Direct conversion of a terminal alkyne group into a beta-methoxyacrylate is realized with the aid of the bis(oxazoline) ligand (box). Acetyl and ketal protecting groups, free hydroxy groups, and acid-sensitive glycosidic bonds are not affected under the reaction conditions. The one-pot synthesis of (+/-)-dihydrokawain from the homopropargyl alcohol is also achieved. tfa = trifluoroacetate.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. kkk@phar.toho-u.ac.jp
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Motodate
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Mochida
authors.forename: Takuya
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Akita
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D009944:Organoplatinum Compounds / Q000737:chemistry*
chemical_list: D000480:Alkynes; D009944:Organoplatinum Compounds