Energy restriction for breast cancer prevention.
Weight gain in adult life is an important risk factor for breast cancer. Observational studies indicate that pre- or postmeno-pausal weight loss is associated with a reduction in risk of postmenopausal breast cancer. Here we summarise lifestyle changes including continuous or intermittent energy restriction and/or exercise which may be beneficial for preventing breast cancer and also potential pharmacological approaches to prevention using energy restriction mimetic agents (ERMAs).
Howell
Anthony
A
Christie Hospital NHS Trust, University of Manchester, CRUK Department of Medical Oncology, UK. maria.parker@christie-tr.nwest.nhs.uk
Chapman
Mary
M
Harvie
Michelle
M
D001943:Breast Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D031204:Caloric Restriction; D004734:Energy Metabolism / Q000502:physiology*; D005081:Exercise Therapy; D005260:Female; D006801:Humans