title: Antibacterial activity and physical properties of glass-ionomer cements containing antibiotics.
abstract: This study evaluated the antibacterial effects, physical properties and bonding strengths of conventional glass-ionomer cements (GICs) containing antibiotics and determined the optimal concentration of antibiotics addition for use with the ART approach. Fuji IX GIC was used as a control. Three antibiotic mixtures, ciprofloxacin, metronidazole and minocycline, were added to powdered GIC (Fuji IX) to obtain concentration ratios of 1.5, 3.0 and 4.5% w/w. The antibacterial activity of each GIC was evaluated against Streptococcus mutans or Lactobacillus casei using agar-diffusion methods. The release of antibiotics was analyzed by high-performance liquid chromatography (HPLC). The compressive strength and bonding strength to dentin were measured and compared with those of control samples. The results were analyzed using the Mann-Whitney test and Wilcoxon test. All tested groups showed a significantly greater inhibition with growth of the selected bacteria in comparison to the control groups (p < 0.01). However, the 3% and 4.5% concentration ratios of antibiotics had significantly lower compressive strength and lower bond strength to dentin than the control group (p = 0.003). The GIC-containing antibiotics were effective in inhibiting S Mutans and L Casei. The addition of a 1.5% antibiotic mixture was optimal to giving appropriate physical and bonding properties.
authors.affiliation: Department of Operative Dentistry, Faculty of Dentistry, Karadeniz Technical University, Trabzon, Turkey. cyesilyurt@ktu.edu.tr
authors.forename: Cemal
authors.initials: C
authors.lastname: Yesilyurt
authors.forename: Kursat
authors.initials: K
authors.lastname: Er
authors.forename: Tamer
authors.initials: T
authors.lastname: Tasdemir
authors.forename: Kurtulus
authors.initials: K
authors.lastname: Buruk
authors.forename: Davut
authors.initials: D
authors.lastname: Celik
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000737:chemistry / Q000494:pharmacology; D015169:Colony Count, Microbial; D019245:Compressive Strength; D001840:Dental Bonding; D003804:Dentin / Q000648:ultrastructure; D004058:Diffusion; D005899:Glass Ionomer Cements / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007780:Lacticaseibacillus casei / Q000187:drug effects; D008422:Materials Testing; D008795:Metronidazole / Q000737:chemistry / Q000494:pharmacology; D008911:Minocycline / Q000737:chemistry / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects; D013314:Stress, Mechanical; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005899:Glass Ionomer Cements; C110713:fuji IX; D008795:Metronidazole; D002939:Ciprofloxacin; D008911:Minocycline