title: [Antitumor activity of L-asparaginase from Yersinia pseudotuberculosis].
abstract: The cytotoxic activity of L-asparaginases from Yersinia pseudotuberculosis and from Erwinia carotovora were investigated in vitro using several tumor cells lines: Jurkat and Molt-4 (human T-lymphoblastic leukemia), MCF-7 (human breast adenocarcinoma), LnCap (human prostate carcinoma), NGUK1 (rat Gasser node neurinoma). E. coli L-asparaginase produced by "Medak" (Germany) was used as a reference. The cell growth inhibition data indicate that Y. pseudotuberculosis L-asparaginase significantly inhibits growth of leukemic and solid tumor cells. These results allow us to conclude that this L-asparaginase can be used for the development of new preparations for the therapy of different types of tumors.
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Abakumova
authors.forename: O V
authors.initials: OV
authors.lastname: Podobed
authors.forename: A A
authors.initials: AA
authors.lastname: Borisova
authors.forename: K V
authors.initials: KV
authors.lastname: Sidoruk
authors.forename: S S
authors.initials: SS
authors.lastname: Aleksandrova
authors.forename: N M
authors.initials: NM
authors.lastname: Omel'ianiuk
authors.forename: M V
authors.initials: MV
authors.lastname: Pokrovskaia
authors.forename: L I
authors.initials: LI
authors.lastname: Kondakova
authors.forename: N N
authors.initials: NN
authors.lastname: Sokolov
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001215:Asparaginase / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D016973:Pectobacterium carotovorum / Q000201:enzymology; D015011:Yersinia pseudotuberculosis / Q000201:enzymology*
chemical_list: D000970:Antineoplastic Agents; D001215:Asparaginase