title: The sequential magnetic resonance images of tri-methyl tin leukoencephalopathy.
abstract: Organotin compounds are commonly used in industrial and agriculture. It causes toxic effects on skin, eyes, respiratory system, gastrointestinal system, and nervous system. After cleaning a di-methyl tin tank, 43-year-old man showed a dizziness, disorientation, visual hallucination, and agitation. Through a measurement by liquid chromatography and inductively coupled plasma-mass spectrometry, di-methyl tin and tri-methyl tin was detected. Although magnetic resonance (MR) image 3 days after exposure showed no abnormal signal intensity, follow-up MR images 15 days after exposure revealed abnormal extensive signal intensities in the white matter that was not ever coincident with previous reports. It was hardly explainable that previous abnormal signal intensities of MR image nearly disappeared 4 months later. We present a case of a patient who developed acute toxic leukoencephalopathy from an acute inhalational exposure to methyl tin with sequential MR images showing an involvement of white matter that was not ever reported.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ulsan University Hospital, University of Ulsan College of Medicine, 290-3 Jeonha-dong, Dong-gu, Ulsan, 682-714, Korea. chhwang1220ciba@yahoo.co.kr
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Hwang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000648:Amnesia, Retrograde / Q000139:chemically induced; D001259:Ataxia / Q000139:chemically induced; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000187:drug effects* / Q000473:pathology* / Q000503:physiopathology; D001925:Brain Damage, Chronic / Q000139:chemically induced* / Q000473:pathology* / Q000503:physiopathology; D003221:Confusion / Q000139:chemically induced; D004244:Dizziness / Q000139:chemically induced; D004401:Dysarthria / Q000139:chemically induced; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D013058:Mass Spectrometry; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000473:pathology; D009498:Neurotoxins / Q000506:poisoning*; D016273:Occupational Exposure / Q000009:adverse effects; D013995:Time; D014298:Trimethyltin Compounds / Q000506:poisoning*
chemical_list: D009498:Neurotoxins; D014298:Trimethyltin Compounds; C046488:trimethyltin