[Effect of yizhi jiannao granules on the expression of Pin1 and HMGB1 mRNA in the hippocampus of SAMP8 mice].
OBJECTIVE
To investigate the effect of yizhi jiannao granule concentration fluid (YCF) on the expression of peptidyl-prolyl-cis-trans isomerase A (Pin1) and high mobility group box 1 (HMGB1) mRNA in the hippocampus of senescence accelerated mice Senile-Prone8(SAMP8).


METHODS
Six-month old SAMP8 mice were randomly divided into a YCF group and a model group. Six-month old SAMP8 mice were served as a normal control group. The YCF group was ravaged, while the model group and the normal control group were gavaged with double-distilled water for 8 weeks. The hippocampus was taken out for examination. The expression of Pin1 and HMGB1 mRNA was measured by RT-PCR.


RESULTS
In the YCF group, the level of Pin1 mRNA increased, and the level of HMGB1 mRNA decreased compared with that of the model group.


CONCLUSIONS
Yizhi jiannao granules can prevent Alzheimer's disease by increasing the Pin1 level and decreasing the HMGB1 level.
Wang
Huiling
H
Changsha Mental Hospital, Changsha 410004,China.
Dong
Keli
K
Li
Guangcheng
G
Peng
Xianwen
X
Zhu
Hong
H
D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D032429:Alpinia; D000544:Alzheimer Disease / Q000378:metabolism; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D024243:HMGB1 Protein / Q000235:genetics / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051379:Mice; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019696:Peptidylprolyl Isomerase / Q000235:genetics / Q000378:metabolism*; D010936:Plant Extracts; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
C442779:Alpinia oxyphylla fruit extract; D004365:Drugs, Chinese Herbal; D024243:HMGB1 Protein; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D010936:Plant Extracts; D012333:RNA, Messenger; D019696:Peptidylprolyl Isomerase; C000606850:Pin1 protein, mouse