Impaired long term memory consolidation in transgenic mice overexpressing the human soluble form of IL-1ra in the brain.
Interleukin-1 (IL-1) is expressed following LTP induction and is required for long-term memory consolidation. We demonstrate that the long-term, but not short-term memory is impaired in a transgenic mouse strain overexpressing the human soluble interleukin-1 receptor antagonist (hsIL-1ra) in the brain. Overexpression of IL-1ra was found to reduce the basal as well as the novelty-induced upregulation of activity-regulated cytoskeleton-associated protein (Arc) in the dentate gyrus and in the retrosplenial cortex. Together with the finding that blocking IL-1 receptors interferes with the BDNF-ERK1/2 pathway, our data suggest an essential role played by physiological levels of IL-1 in long-term memory consolidation.
Spulber
Stefan
S
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. stefan.spulber@ki.se
Mateos
Laura
L
Oprica
Mircea
M
Cedazo-Minguez
Angel
A
Bartfai
Tamas
T
Winblad
Bengt
B
Schultzberg
Marianne
M
D000818:Animals; D018891:Dentate Gyrus / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008822:Mice, Transgenic; D012995:Solubility
D053590:Interleukin 1 Receptor Antagonist Protein