Bacterial infections as complications in patients within 3 months after simultaneous pancreas-kidney transplantation.
BACKGROUND
Simultaneous pancreas-kidney transplantation (SPK) is associated with high risk of infectious complications.


OBJECTIVE
The aim of the study was to evaluate the incidence of bacterial infections within 3 months after SPK transplantation.


METHODS
17 patients with type 1 diabetes at the age of 32-54 years (mean age 42.5 +/- 7.1) were retrospectively analyzed within 3 months after SPK.


RESULTS
No septic complications were observed in 2 patients (12%). In the remaining 15 patients (88%), at least 1 (from 1 to 5, a total of 30) infection episode was observed during follow-up. The infections were located: only at the surgical site (1 patient--6.7%), only in the urinary tract (6 patients--40%), both at the surgical site and in the urinary tract (7 patients--46.7%), at the surgical site and in blood (1 patient--6.7%). 2 groups of microbes were predominant, namely enterococci represented by 1 species, E. faecium (13 isolates) and the so-called intestinal bacilli, Enterobacteriaceae (19 isolates). No methicillin resistant Staphylococcus aureus strains were isolated. Candida species fungi were isolated only 3 times.


CONCLUSIONS
In our study only 2 types of infections were observed (urinary tract and surgical site infections) and each of them comprised nearly half of all the septic episodes recorded. Gram-negative bacilli were collected more often than Gram-positive cocci, both from the surgical site and urinary tract infections. All infections ended with full recovery.
Milczarczyk
Alicja
A
Department of Internal Diseases, Endocrinology and Diabetology, Central Clinical Hospital Ministry of Interior and Administration, Warszawa, Poland.
Filczak
Krzysztof
K
Serwacka
Agnieszka
A
Durlik
Marek
M
Rydzewski
Andrzej
A
Franek
Edward
E
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000601:surgery; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation / Q000009:adverse effects*; D011044:Poland; D012189:Retrospective Studies; D018805:Sepsis / Q000382:microbiology; D013530:Surgical Wound Infection / Q000178:diet therapy / Q000382:microbiology*; D016896:Treatment Outcome; D014552:Urinary Tract Infections / Q000382:microbiology*