[Biologically active compounds in the mechanism of formation of reflux-nephropathy in children].
A concept is proposed laying emphasis on the involvement of cytokines, growth factors, prostaglandins, and nitrogen oxides in the mechanism of formation of reflux-nephropathy in children. It is shown that enhanced production of mediators of inflammation and humoral growth factors in patients with vesico-ureter reflux depends on the degree of infiltrative and sclerotic changes in the kidneys. The accompanying dysbalance of pro- and anti-inflammatory cytokines due to increased endogeneous production of TNF-alpha and concomitant decrease of daily BL-10 excretion constitutes an unfavourable prognostic factor of reflux-nephropathy. There is evidence that inclusion of ACE inhibitors (Enap) in therapy of vesico-ureter reflux during 6 months leads to a marked improvement of the structural and functional state of the kidneys. It suggests high renoprotective potential of these preparations and the possibility of their use for prophylaxis of nephrosclerosis in children.
Studenikin
M Ia
MIa
Smirnov
I E
IE
Paunova
S S
SS
Kucherenko
A G
AG
D000293:Adolescent; D015415:Biomarkers; D002648:Child; D002675:Child, Preschool; D016207:Cytokines / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D011704:Pyelonephritis / Q000453:epidemiology / Q000276:immunology / Q000503:physiopathology; D014563:Urodynamics / Q000502:physiology; D014718:Vesico-Ureteral Reflux / Q000453:epidemiology*
D015415:Biomarkers; D016207:Cytokines