title: Influence of oligosaccharides on the growth and tolerance capacity of lactobacilli to simulated stress environment.
abstract: OBJECTIVE
  Lactobacilli should resist stress environments in industry process and gastrointestinal tract before exerting their beneficial effects. To explore the possible stabilizers in probiotic products, prebiotic oligosaccharides were investigated.
  
  
  RESULTS
  We investigated the effect of four selected oligosaccharides on the survival of probiotic Lactobacillus plantarum and L. acidophilus to simulated stress conditions. It was found that the tolerance of lactobacilli to simulated artificial gastrointestinal juice, heat treatment and phenol solution was obviously enhanced in fructo-oligosaccharides (FOS) and xylo-oligosaccharides (XOS) group. In addition, chito-oligosaccharides (COS), manno-oligosaccharides (MOS) and glucose also had positive effect compared with control group (without sugar).
  
  
  CONCLUSIONS
  Prebiotic oligosaccharides, especially XOS and FOS added in medium have protection function to lactobacilli in stress environments. The protection function of oligosaccharides may correlate with the bacteria growth, which was stimulated by these oligosaccharides.
  
  
  CONCLUSIONS
  Prebiotic oligosaccharides may be used as stabilizers in probiotic products.
authors.affiliation: Department of Chemistry, Chemistry and Bioengineering Center, Zhejiang University, Hangzhou, China.
authors.forename: X
authors.initials: X
authors.lastname: Pan
authors.forename: T
authors.initials: T
authors.lastname: Wu
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Cai
authors.forename: Z
authors.initials: Z
authors.lastname: Song
mesh_terms: D015169:Colony Count, Microbial; D005750:Gastric Juice / Q000502:physiology; D018869:Heat-Shock Response / Q000187:drug effects*; D006801:Humans; D007779:Lactobacillus acidophilus / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology; D048191:Lactiplantibacillus plantarum / Q000187:drug effects / Q000254:growth & development* / Q000502:physiology; D009844:Oligosaccharides / Q000737:chemistry / Q000494:pharmacology*; D019936:Probiotics
chemical_list: D009844:Oligosaccharides; C116580:fructooligosaccharide