Heart rate variability, ambient particulate matter air pollution, and glucose homeostasis: the environmental epidemiology of arrhythmogenesis in the women's health initiative.
Metabolic neuropathophysiology underlying the prediabetic state may confer susceptibility to the adverse health effects of ambient particulate matter <10 microm in diameter (PM(10)). The authors therefore examined whether impaired glucose homeostasis modifies the effect of PM(10) on heart rate variability in a stratified, random sample of 4,295 Women's Health Initiative clinical trial participants, among whom electrocardiograms and fasting blood draws were repeated at 3-year intervals from 1993 to 2004. In multilevel, mixed models weighted for sampling design and adjusted for clinical and environmental covariables, PM(10) exposure was inversely associated with heart rate variability. Inverse PM(10)-heart rate variability associations were strongest for the root mean square of successive differences in normal-to-normal RR intervals (RMSSD). Among participants with impaired fasting glucose, there were -8.3% (95% confidence interval: -13.9, -2.4) versus -0.6% (95% confidence interval: -2.4, 1.3), -8.4% (95% confidence interval: -13.8, -2.7) versus -0.3% (95% confidence interval: -2.1, 1.6), and -4.3% (95% confidence interval: -9.4, 1.0) versus -0.8% (95% confidence interval: -2.7, 1.0) decreases in the RMSSD per 10-microg/m(3) increase in PM(10) at high versus low levels of insulin (P < 0.01), insulin resistance (P < 0.01), and glucose (P = 0.16), respectively. These associations were stronger among participants with diabetes and weaker among those without diabetes or impaired fasting glucose. The findings suggest that insulin and insulin resistance exacerbate the adverse effect of PM(10) on cardiac autonomic control and thus risk of coronary heart disease among nondiabetic, postmenopausal women with impaired fasting glucose.
Whitsel
Eric A
EA
Cardiovascular Disease Program, Departments of Epidemiology and Medicine, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514, USA. ewhitsel@email.unc.edu
Quibrera
P Miguel
PM
Christ
Sharon L
SL
Liao
Duanping
D
Prineas
Ronald J
RJ
Anderson
Garnet L
GL
Heiss
Gerardo
G
D000368:Aged; D000393:Air Pollutants / Q000633:toxicity*; D001145:Arrhythmias, Cardiac / Q000209:etiology* / Q000503:physiopathology*; D001786:Blood Glucose / Q000032:analysis*; D004562:Electrocardiography; D004782:Environmental Health; D004784:Environmental Monitoring; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D008875:Middle Aged; D015233:Models, Statistical; D052638:Particulate Matter / Q000633:toxicity*; D017698:Postmenopause; D016032:Randomized Controlled Trials as Topic
D000393:Air Pollutants; D001786:Blood Glucose; D052638:Particulate Matter