title: IGL-1 solution in kidney transplantation: first multi-center study.
abstract: IGL-1 solution is characterized by inversion of K+ and Na+ concentrations in the University Wisconsin (UW) solution and polyethylene glycol 35 (PEG 35) substitution for hydroxy ethyl starch. In this prospective study, 121 patients transplanted with kidneys preserved in IGL-1 solution were compared to 102 patients grafted with kidneys preserved in UW solution. Serum creatinine and creatinine clearance, delayed graft function (DGF) and rejection episodes, patient and graft survival were evaluated in the first post-transplant year. Groups were comparable regarding to donor and recipient characteristics. Median creatinine levels were significantly lower in IGL-1 group from day 6 to day 14 and it decreased more rapidly in the IGL-1 group (from day 4 to day 15: p < 0.05). Creatinine clearance values were usually higher in the IGL-1 group for the first 15 d. During the follow-up period serum creatinine concentrations were lower in IGL-1 group at one, three, six and 12 months after transplantation (p = 0.04; p = 0.06, p = 0.01 and p = 0.08, respectively) while creatinine clearance values were similar during the follow-up. No significant difference in DGF and rejection rates as well as in patient and graft survival was shown between the two groups. Kidneys preserved in IGL-1 solution showed to have the same function as kidneys preserved in UW solution.
authors.affiliation: Department of Urology and Transplant Surgery, Edouard Herriot Hospital, Centaure Network, Lyon, France.
authors.forename: Ricardo
authors.initials: R
authors.lastname: Codas
authors.forename: Palmina
authors.initials: P
authors.lastname: Petruzzo
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Morelon
authors.forename: Nicole
authors.initials: N
authors.lastname: Lefrançois
authors.forename: Fabrice
authors.initials: F
authors.lastname: Danjou
authors.forename: Celine
authors.initials: C
authors.lastname: Berthillot
authors.forename: Paolo
authors.initials: P
authors.lastname: Contu
authors.forename: Michele
authors.initials: M
authors.lastname: Espa
authors.forename: Xavier
authors.initials: X
authors.lastname: Martin
authors.forename: Lionel
authors.initials: L
authors.lastname: Badet
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D019188:Organ Preservation Solutions; D011446:Prospective Studies; D055815:Young Adult
chemical_list: C504757:IGL-1 solution; D019188:Organ Preservation Solutions; D003404:Creatinine