Acute childhood leukaemia and residence next to petrol stations and automotive repair garages: the ESCALE study (SFCE).
BACKGROUND
The association between acute childhood leukaemia and residing next to petrol stations and automotive repair garages was analysed in a national registry-based case-control study carried out in France in 2003-2004.


METHODS
Population controls were frequency matched with cases on age and gender. Data were collected by standardised telephone interview with the mothers. The latter were asked to report the proximity of their homes to petrol stations, automotive repair garages and other businesses from the conception of the index child to the diagnosis (for cases) or interview (for controls). Odds ratios were estimated using unconditional regression models adjusted for age, gender, number of children under 15 years of age in the household, degree of urbanisation and type of housing.


RESULTS
765 cases of acute leukaemia and 1681 controls were included. Acute leukaemia was significantly associated with residence next to petrol stations or automotive repair garages (OR 1.6, 95% CI 1.2 to 2.2) and next to a petrol station (OR 1.9, 95% CI 1.2 to 3.0). The OR showed no tendency to increase with duration of exposure. The results were not modified by adjustment for potential confounding factors including urban/rural status and type of housing.


CONCLUSIONS
The results support the findings of our previous study and suggest that living next to a petrol station may be associated with acute childhood leukaemia. The results also suggest that the role of low-level exposure to benzene in acute childhood leukaemia deserves further evaluation.
Brosselin
P
P
INSERM U754, 16, Avenue Paul Vaillant Couturier, F-94807 Villejuif Cedex, France.
Rudant
J
J
Orsi
L
L
Leverger
G
G
Baruchel
A
A
Bertrand
Y
Y
Nelken
B
B
Robert
A
A
Michel
G
G
Margueritte
G
G
Perel
Y
Y
Mechinaud
F
F
Bordigoni
P
P
Hémon
D
D
Clavel
J
J
D000208:Acute Disease; D000293:Adolescent; D017677:Age Distribution; D000393:Air Pollutants / Q000009:adverse effects; D001554:Benzene / Q000009:adverse effects; D002274:Carcinogens, Environmental / Q000009:adverse effects; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004522:Educational Status; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D005260:Female; D005602:France / Q000453:epidemiology; D005742:Gasoline / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000453:epidemiology* / Q000209:etiology; D008297:Male; D012111:Residence Characteristics; D017678:Sex Distribution; D012923:Social Class
D000393:Air Pollutants; D002274:Carcinogens, Environmental; D005742:Gasoline; D001554:Benzene