title: Lung cancer: developmental networks gone awry?
abstract: High-throughput genomic data for both lung development and lung cancer continue to accumulate. Significant molecular intersection between these two processes has been hypothesized due to overlap in phenotypes and genomic variation. Examining the network biology of both cancer and development of the lung may shed functional light on the individual signaling modules involved. Stem cell biology may explain a portion of this network intersection and consequently studying lung organogenesis may have relevance for understanding lung cancer. This review summarizes our understanding of the potential overlapping mechanisms involved in lung development and lung tumorigenesis.
authors.affiliation: Division of General Thoracic Surgery, Mayo Clinic Cancer Center, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Thomas
authors.initials: T
authors.lastname: Kislinger
authors.forename: Igor
authors.initials: I
authors.lastname: Jurisica
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Wigle
mesh_terms: D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D053263:Gene Regulatory Networks; D006801:Humans; D008168:Lung / Q000196:embryology* / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism; D038081:Organogenesis / Q000235:genetics*; D015398:Signal Transduction; D013234:Stem Cells / Q000502:physiology