title: Modulation of the efficacy of temozolomide and dacarbazine melanoma treatment by DNA-repair factors in vivo and in vitro.
authors.affiliation: Department of Dermatology, University of Goettingen, Germany. lboeckm@gwdg.de
authors.forename: L
authors.initials: L
authors.lastname: Boeckmann
authors.forename: K-M
authors.initials: KM
authors.lastname: Thoms
authors.forename: R
authors.initials: R
authors.lastname: Gutzmer
authors.forename: C
authors.initials: C
authors.lastname: Has
authors.forename: M
authors.initials: M
authors.lastname: Kunz
authors.forename: C
authors.initials: C
authors.lastname: Kuschal
authors.forename: P
authors.initials: P
authors.lastname: Laspe
authors.forename: D
authors.initials: D
authors.lastname: Struever
authors.forename: S
authors.initials: S
authors.lastname: Emmert
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000502:physiology; D002986:Clinical Trials as Topic; D015254:DNA Modification Methylases / Q000235:genetics / Q000378:metabolism; D045643:DNA Repair Enzymes / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology / Q000378:metabolism; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D008745:Methylation; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein / Q000235:genetics / Q000378:metabolism; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D011355:Prodrugs / Q000378:metabolism; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000077204:Temozolomide; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018906:Antineoplastic Agents, Alkylating; C501486:MLH1 protein, human; D009687:Nuclear Proteins; D011355:Prodrugs; D012333:RNA, Messenger; D025521:Tumor Suppressor Proteins; D003606:Dacarbazine; D015254:DNA Modification Methylases; C515491:MGMT protein, human; C497172:MSH2 protein, human; D000070957:MutL Protein Homolog 1; D051718:MutS Homolog 2 Protein; D045643:DNA Repair Enzymes; D000077204:Temozolomide