title: Is Candida colonization of central vascular catheters in non-candidemic, non-neutropenic patients an indication for antifungals?
abstract: OBJECTIVE
  To assess the influence of antifungal therapy on the outcome of non-candidemic adult patients with central vascular catheter (CVC) tips colonized by Candida species.
  
  
  METHODS
  A retrospective analysis of the outcome of patients with Candida colonization of their CVC tip and no concurrent candidemia was made over a 4-year period. Patients who either died or developed candidemia-invasive candidiasis (poor outcome) were compared with those who improved.
  
  
  RESULTS
  We finally included 58 patients for analysis. Almost all (91.4%) had to be admitted to the ICU during their hospital stay. Independent predictors for outcome were a McCabe and Jackson score corresponding to ultimately fatal underlying disease [odds ratio (OR) 11.98; 95% confidence interval (CI), 1.37-104.97; P = 0.02], and maximum severity corresponding to severe sepsis, septic shock or multiorgan failure (OR: 6.16, CI 95%: 1.00-37.93; P = 0.05). We were unable to demonstrate that antifungal therapy was an independent variable influencing outcome (OR 0.82; 95% CI, 0.27-2.47; P = 0.73).
  
  
  CONCLUSIONS
  Our data suggest that, in non-neutropenic critically ill patients with no concomitant candidemia and with CVC tips colonized by Candida, antifungal therapy does not seem to have a significant influence on clinical outcome.
authors.affiliation: Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Universidad Complutense, Madrid, Spain. alfonsperezp@gmail.com
authors.forename: Alfonso
authors.initials: A
authors.lastname: Pérez-Parra
authors.forename: Patricia
authors.initials: P
authors.lastname: Muñoz
authors.forename: Jesús
authors.initials: J
authors.lastname: Guinea
authors.forename: Pablo
authors.initials: P
authors.lastname: Martín-Rabadán
authors.forename: María
authors.initials: M
authors.lastname: Guembe
authors.forename: Emilio
authors.initials: E
authors.lastname: Bouza
mesh_terms: D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology*; D000077336:Caspofungin; D002405:Catheterization, Central Venous; D002408:Catheters, Indwelling / Q000382:microbiology*; D018450:Disease Progression; D054714:Echinocandins / Q000627:therapeutic use*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D055666:Lipopeptides; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D015725:Fluconazole; D000077336:Caspofungin