title: Anti-mullerian hormone is associated with advanced glycosylated end products in lean women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Oocyte maturation process characterizes polycystic ovary syndrome (PCOS). The mechanisms of this abnormality leading to chronic anovulation are under investigation. Advanced glycosylated end products (AGEs), a marker of oxidative stress linked with oocyte maturation are localized in granulosa cells and are increased in sera, in women with PCOS. The aim of this study was to investigate the relationship, whether there is an association between the anti-mullerian hormone (AMH), a hormone produced by granulosa cells and AGEs in ovulatory and anovulatory PCOS (PCOS-Anov), as well as in non-PCOS anovulatory (Non-PCOS Anov) women. Design Cross-sectional study.
  
  
  METHODS
  Data from sixty women with PCOS (37 anovulatory and 23 regularly ovulating) were compared with eleven Non-PCOS Anov women and 25 normal women. In each subject biochemical, hormonal, and ultrasonographic parameters were studied.
  
  
  RESULTS
  AMH values were statistically significantly higher in PCOS-Anov (7.63+/-3.12) in comparison with ovulatory PCOS (PCOS-Ov; 4.92+/-2.50), Non-PCOS Anov (3.66+/-1.4), and controls (4.02+/-1.27 ng/ml). AGEs demonstrated a similar pattern: 8.70+/-1.65 in PCOS-Anov, 7.43+/-1.79, PCOS-Ov, 5.21+/-0.09, Non-PCOS Anov, and 5.85+/-0.89 U/ml in controls (P<0.005 for all comparison respectively). Follicle number was significantly higher in PCOS-Anov in comparison with other groups. A significant positive correlation between AMH and AGEs was observed (r: 0.326, P<0.01), and with the estimated AMH/AGEs ratio to follicle number (r: 0.42, P: 0.0001) and the presence of anovulation.
  
  
  CONCLUSIONS
  These data suggest that an oxidative marker, AGEs, and AMH, may interact in the anovulatory mechanisms in women with PCOS.
authors.affiliation: Endocrine Section, First Department of Medicine, University of Athens Medical School, Mikras Asias 75, Goudi 115-27, Athens, Greece. akandara@otenet.gr
authors.forename: Evanthia
authors.initials: E
authors.lastname: Diamanti-Kandarakis
authors.forename: Athanasia
authors.initials: A
authors.lastname: Piouka
authors.forename: Sarantis
authors.initials: S
authors.lastname: Livadas
authors.forename: Christine
authors.initials: C
authors.lastname: Piperi
authors.forename: Ilias
authors.initials: I
authors.lastname: Katsikis
authors.forename: Athanasios G
authors.initials: AG
authors.lastname: Papavassiliou
authors.forename: Demetrios
authors.initials: D
authors.lastname: Panidis
mesh_terms: D000328:Adult; D000858:Anovulation / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D010053:Ovary / Q000000981:diagnostic imaging; D010060:Ovulation / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D013851:Thinness / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D014463:Ultrasonography; D055815:Young Adult
chemical_list: D017127:Glycation End Products, Advanced; D054304:Anti-Mullerian Hormone