title: Carbonic anhydrase-inhibiting medications and the intracarotid amobarbital procedure in children.
abstract: The intracarotid amobarbital procedure (IAP) is routinely conducted as part of the presurgical evaluation of pediatric patients with epilepsy. The aim of the present study was to investigate the possibility that anesthetization failures are the result of interactions of carbonic anhydrase-inhibiting (CAI) medications with sodium amobarbital. An archival review of 81 cases conducted between 1999 and 2008 was performed across two pediatric epilepsy centers. chi(2) analysis was used to assess whether CAI medications interfered with the outcome of these procedures. Of 81 patients, 85.2% had conclusive findings. All of the remaining 14.8% with anesthetization failures were taking CAI medications at the time of the procedure. However, 53.8% of patients taking CAI medications had conclusive results. This suggests that these medications may interact with sodium amobarbital, raising the possibility of anesthetization failures in children prescribed CAI medications.
authors.affiliation: Department of Neuropsychology, Epilepsy Center, Children's Healthcare of Atlanta, 1001 Johnson Ferry Road, Atlanta, GA 30342, USA. burns1@mindspring.com
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Burns
authors.forename: Gregory P
authors.initials: GP
authors.lastname: Lee
authors.forename: Megan L
authors.initials: ML
authors.lastname: McCormick
authors.forename: Ashley N
authors.initials: AN
authors.lastname: Pettoni
authors.forename: J Robert
authors.initials: JR
authors.lastname: Flamini
authors.forename: Morris
authors.initials: M
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000654:Amobarbital / Q000009:adverse effects*; D000758:Anesthesia / Q000009:adverse effects / Q000379:methods*; D000927:Anticonvulsants / Q000627:therapeutic use; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D002648:Child; D004827:Epilepsy / Q000175:diagnosis* / Q000188:drug therapy / Q000601:surgery; D005260:Female; D007839:Functional Laterality / Q000187:drug effects; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D012189:Retrospective Studies
chemical_list: D000927:Anticonvulsants; D002257:Carbonic Anhydrase Inhibitors; D000654:Amobarbital