Salmochelin, the long-overlooked catecholate siderophore of Salmonella.
Salmochelin is a C-glucosylated enterobactin produced by Salmonella species, uropathogenic and avian pathogenic Escherichia coli strains, and certain Klebsiella strains. It was the first glucosylated siderophore described. The glucosylation has been interpreted as a bacterial evasion mechanism against the mammalian catecholate siderophore-binding protein siderocalin (NGAL-lipocalin). The synthesis, excretion, and uptake of salmochelin requires five genes, iroBCDEN, and also the enterobactin biosynthesis and utilization system. Some salmochelin-producing strains also secrete microcins, which possess a C-terminal, linear glucosyl-enterobactin moiety. These microcins recognize the catecholate siderophore receptors IroN, Cir, Fiu, and FepA, and may inhibit the growth of competitors for catecholate siderophores.
Müller
Silke I
SI
Lehrstuhl für Mikrobiologie - Organismische Interaktionen, Universität Tübingen, Germany.
Valdebenito
Marianne
M
Hantke
Klaus
K
D001692:Biological Transport / Q000502:physiology; D004758:Enterobactin / Q000235:genetics / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D012475:Salmonella / Q000235:genetics / Q000378:metabolism*; D017262:Siderophores / Q000235:genetics / Q000378:metabolism*
D017262:Siderophores; D004758:Enterobactin; D007501:Iron