[Study of blood pressure variability in arterial hypertension and relation with glomerular filtration].
OBJECTIVE
Besides reducing blood pressure, it is important to think about the blood pressure variability that hypertensive patients may present. Indeed, studies suggest that target organ damage is greater in hypertensive people with high blood pressure variability. The purpose of the present study was to determine the blood pressure variability in patients who had not been treated with antihypertensive medication, as well as its relationship with the glomerular filtration.


METHODS
We included 702 patients with clinical indication for 24h ambulatory blood pressure monitoring.


RESULTS
43.6% of patients had high variability of the blood pressure. These patients had greater levels of 24-h systolic blood pressure, diurnal and night blood pressure and a lower glomerular filtration. The main factors associated with high blood pressure variability were age, years from diagnosis of arterial hypertension, systolic blood pressure and a glomerular filtration smaller than 60ml/min.


CONCLUSIONS
A high variability of blood pressure is frequent among hypertensive patients. Since it is not possible to perform ambulatory blood pressure measurement in all them, we should mainly suspect it in old patients and in those with reduced glomerular filtration.
Mediavilla García
Juan Diego
JD
Unidad de HTA y Lípidos, Servicio de Medicina Interna, Hospital Universitario Virgen de las Nieves, Granada, España. jdmediavillag@hotmail.com
Fernández-Torres
Celia
C
Arroyo Nieto
Ascensión
A
Expósito Ruiz
Manuela
M
Jiménez-Alonso
Juan
J
D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies