title: Exercise performance and quality of life following surgical repair of anomalous aortic origin of a coronary artery in the pediatric population.
abstract: OBJECTIVE
  We sought to evaluate exercise performance and quality of life in children after surgical repair of anomalous aortic origin of a coronary artery with an interarterial course.
  
  
  METHODS
  Patients who had surgery from October 2001 to January 2007 were eligible for inclusion. Exercise performance and quality of life were prospectively assessed by maximal exercise tests and age-appropriate questionnaires, respectively. We used t tests to compare pre- and postoperative exercise data and quality-of-life scores to published normative data. We performed linear regression analyses to assess associations between demographic, anatomic, and exercise variables and quality-of-life score.
  
  
  RESULTS
  Of 25/27 patients, 64% were boys, 68% had anomalous right coronary, 32% were asymptomatic. Average age at surgery was 10.8 (+/-4.1) years; median follow-up was 14.5 (2 to 48) months. Postoperative percent-predicted exercise values were: peak heart rate 97 (+/-6), working capacity 91 (+/-15), maximal oxygen consumption 82 (+/-16). In those who had preoperative exercise testing (n = 11), resting and maximal heart rates decreased significantly without significant change in exercise performance. Average child quality of life was 85/100 (+/-13) and parent-proxy 88 (+/-11) compared with normal scores of 83 (+/-15) and 88 (+/-12), respectively.
  
  
  CONCLUSIONS
  There is mild chronotropic impairment in children and adolescents following anomalous coronary artery repair without a decline in exercise performance. This does not appear to impair their overall quality of life. Because long-term effects on heart rate, exercise performance, and quality of life are unknown, serial exercise tests should be included as routine care of these patients.
authors.affiliation: Division of Cardiology, The Children's Hospital of Philadelphia and the University of Pennsylvania, Philadelphia, Penn, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Brothers
authors.forename: M G
authors.initials: MG
authors.lastname: McBride
authors.forename: B S
authors.initials: BS
authors.lastname: Marino
authors.forename: R S
authors.initials: RS
authors.lastname: Tomlinson
authors.forename: M A
authors.initials: MA
authors.lastname: Seliem
authors.forename: M H
authors.initials: MH
authors.lastname: Pampaloni
authors.forename: J W
authors.initials: JW
authors.lastname: Gaynor
authors.forename: T L
authors.initials: TL
authors.lastname: Spray
authors.forename: S M
authors.initials: SM
authors.lastname: Paridon
mesh_terms: D000293:Adolescent; D001011:Aorta / Q000002:abnormalities*; D002648:Child; D003330:Coronary Vessel Anomalies / Q000601:surgery*; D004562:Electrocardiography; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006801:Humans; D008297:Male; D011184:Postoperative Period; D011788:Quality of Life