title: Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience.
abstract: OBJECTIVE
  To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer.
  
  
  METHODS
  Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2-50 Gy) and 2.5 Gy (range 1.8-3 Gy).
  
  
  RESULTS
  The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy(10) or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively.
  
  
  CONCLUSIONS
  Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.
authors.affiliation: Gastrointestinal Oncology Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mayahara
authors.forename: Atsuo
authors.initials: A
authors.lastname: Takashima
authors.forename: Takako Eguchi
authors.initials: TE
authors.lastname: Nakajima
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Ito
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Kagami
authors.forename: Jun
authors.initials: J
authors.lastname: Itami
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimada
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000473:pathology / Q000532:radiotherapy*; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016019:Survival Analysis