title: The use of boluses of propofol for the management of severe tetanus in a child.
abstract: Tetanus is endemic in many developing countries. Although propofol has been proposed for sedation in tetanus, the routine use of this drug has not been clearly documented in published reports. A few studies have reported its beneficial effects but no randomized studies are available. We describe the case of a five-year-old boy who presented with severe tetanus in East Africa. The antispastic therapy consisted of benzodiazepine infusion with the addition of titrated boluses of propofol. Intubation and mechanical ventilation were avoided.
authors.affiliation: Department of Anesthesiology and Intensive Care, Desgenettes Military Hospital, 108 bd Pinel, 69003 Lyon, France. fabricepetitjeans@yahoo.fr
authors.forename: Fabrice
authors.initials: F
authors.lastname: Petitjeans
authors.forename: Jean
authors.initials: J
authors.lastname: Turc
authors.forename: Olivier
authors.initials: O
authors.lastname: Coulet
authors.forename: Marc
authors.initials: M
authors.lastname: Puidupin
authors.forename: Olivier
authors.initials: O
authors.lastname: Eve
authors.forename: Alain
authors.initials: A
authors.lastname: Benois
mesh_terms: D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000627:therapeutic use; D012720:Severity of Illness Index; D013035:Spasm / Q000517:prevention & control; D013742:Tetanus / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D000927:Anticonvulsants; D001569:Benzodiazepines; D015742:Propofol