The timing of intra-coronary infusion of G-CSF mobilized peripheral blood stem cells influences cardiac function and in-stent restenosis in patients with myocardial infarction.
We hypothesized that delaying the timing of intra-coronary infusion of G-CSF mobilized stem cell until at least 4 weeks after coronary stenting should avoid the stimulation of vascular smooth muscle cells during the early active cellular proliferative phase, thus decreases in-stent restenosis while preserving the beneficial effect of stem cell therapy on cardiac function in patients with myocardial infarction (MI). 25 patients with ST-elevation myocardial infarction (STEMI) treated with stenting were enrolled in this pilot study. The ages of MI at the time of cell treatment were from 1 month to 59 months. At 6 months follow-up, the left ventricular ejection fraction (LVEF) increased from 32% to 37.7% and the stress thallium perfusion defect decreased from 31.4% to 28.1%. Cell treatment-related complications such as arrhythmias were not observed. 9 patients who underwent cell treatment less than 3 months after coronary stenting were evaluated for in-stent restenosis; it was found in only 1 patient. This pilot study shows that delayed more than 4 weeks after coronary stenting but less than 3 months after MI, intra-coronary infusion of G-CSF mobilized PBSCs may improve cardiac function without triggering in-stent restenosis.
Kim
Kyung-Soo
KS
Jin
Jiyong
J
Lee
Young-Yiul
YY
Choi
Sung-Il
SI
Shin
Jin-Ho
JH
Kim
Jeong-Hyun
JH
Lim
Heon-Gil
HG
Lee
Bang-Hun
BH
Choi
Yun-Young
YY
Lee
Seok-Mo
SM
Koh
Hyun-Chul
HC
D002675:Child, Preschool; D023903:Coronary Restenosis / Q000628:therapy*; D004334:Drug Administration Schedule; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009203:Myocardial Infarction / Q000628:therapy*; D015607:Stents / Q000009:adverse effects; D016277:Ventricular Function, Left / Q000502:physiology*
D016179:Granulocyte Colony-Stimulating Factor