Molecular combo of photodynamic therapeutic agent silicon(iv) phthalocyanine and anticancer drug cisplatin.
The combination of a red light PDT agent and a Pt(ii)-based chemotherapeutic drug at the molecular level maintains the intrinsic functions of each unit; the conjugated complexes exhibit remarkable photocytoxicity and demonstrate potential to serve as agents for DNA-targeting PDT as well as red light photochemotherapy.
Mao
Jiafei
J
State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
Zhang
Yangmiao
Y
Zhu
Jianhui
J
Zhang
Changli
C
Guo
Zijian
Z
D000970:Antineoplastic Agents / Q000737:chemistry*; D000971:Antineoplastic Combined Chemotherapy Protocols; D002945:Cisplatin / Q000737:chemistry* / Q000627:therapeutic use; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D008027:Light; D018613:Microscopy, Confocal; D015394:Molecular Structure; D010778:Photochemotherapy; D011838:Radiation-Sensitizing Agents / Q000737:chemistry* / Q000627:therapeutic use; D012825:Silicon / Q000737:chemistry; D013194:Staining and Labeling; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D007211:Indoles; D054833:Isoindoles; D011838:Radiation-Sensitizing Agents; D002945:Cisplatin; C013647:phthalocyanine; D012825:Silicon