Screening hydrolysis products of sulfur mustard agents by high-performance liquid chromatography with inductively coupled plasma mass spectrometry detection.
Sulfur mustard (HD), bis(2-chloroethyl)sulfide, is one of a class of mustard agents which are chemical warfare agents. The main chemical warfare hydrolysis degradation products of sulfur mustards are: thiodiglycol, bis(2-hydroxyethylthio)methane, 1,2-bis(2-hydroxyethylthio)ethane, 1,3-bis(2-hydroxyethylthio)propane, and 1,4-bis(2-hydroxyethylthio)butane. The aim of this study is to identify these five hydrolysis degradation products utilizing reversed-phase high-performance liquid chromatography coupled with inductively coupled plasma mass spectrometry (ICP-MS) for element-specific sulfur detection using a collision/reaction cell and electrospray ionization mass spectrometry to confirm the identification. To date, this is the first study utilizing ICP-MS with (32)S element-specific detection for the analysis of vesicant chemical warfare agent degradation products.
Kroening
Karolin K
KK
Department of Chemistry, University of Cincinnati, Cincinnati, OH 45221-0172, USA. kroninkk@email.uc.edu
Richardson
Douglas D
DD
Afton
Scott
S
Caruso
Joseph A
JA
D002073:Butanes / Q000032:analysis*; D002619:Chemical Warfare Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006868:Hydrolysis; D013058:Mass Spectrometry / Q000379:methods; D008697:Methane / Q000031:analogs & derivatives* / Q000032:analysis; D009151:Mustard Gas / Q000032:analysis*; D011407:Propane / Q000031:analogs & derivatives* / Q000032:analysis; D015203:Reproducibility of Results; D013438:Sulfhydryl Compounds / Q000032:analysis* / Q000737:chemistry*
C541395:1,3-bis(2-hydroxyethylthio)propane; C541396:1,4-bis(2-hydroxyethylthio)butane; D002073:Butanes; D002619:Chemical Warfare Agents; D013438:Sulfhydryl Compounds; C541394:bis(2-hydroxyethylthio)methane; C047519:2,2'-thiodiethanol; D008697:Methane; D011407:Propane; D009151:Mustard Gas