title: Comparison of the incidence of de novo solid malignancies after heart transplantation to that in the general population.
abstract: An increased incidence of lymphomas and skin cancers has been shown in heart transplant recipients compared with the general population. However, the incidence of de novo solid tumors in heart transplant recipients has not been compared with the general population. Accordingly, 851 consecutive adult heart transplant recipients at a single large center were followed up from January 1, 1994, to May 31, 2007, to determine the incidence and type of de novo solid-tumor malignancies. The observed incidence of each cancer type was compared with the expected incidence from the Surveillance Epidemiology End Result database, matching for age, gender, and race. Observed counts divided by expected counts yielded a standardized incidence ratio (SIR), which was tested for significance. Of 851 patients, 73 (8.6%) developed de novo solid-tumor malignancies. Sixty men (83.3%) and 12 women (16.7%) aged 58 +/- 8 years at transplantation were given a diagnosis of cancer at age 62 +/- 8 years. Cancers were divided into 22 categories, and the 3 most frequent cancers were prostate (22), lung (8), and breast (6). SIRs were increased for cervical cancer (SIR 14.3, 95% confidence interval 1.7 to 51.5) and thyroid cancer (SIR 7.7, 95% confidence interval 1.6 to 22.5). Logistic regression showed that age and retransplantation were significant risk factors for cancer. In conclusion, heart transplant recipients did not have a significantly increased frequency of many common malignancies despite long-term immunosuppression.
authors.affiliation: Department of Medicine, Columbia University, New York, New York, USA.
authors.forename: Lisa
authors.initials: L
authors.lastname: Kellerman
authors.forename: Alfred
authors.initials: A
authors.lastname: Neugut
authors.forename: Benita
authors.initials: B
authors.lastname: Burke
authors.forename: Donna
authors.initials: D
authors.lastname: Mancini
mesh_terms: D000368:Aged; D005260:Female; D006084:Graft Rejection / Q000517:prevention & control; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D018426:SEER Program; D014481:United States
chemical_list: D007166:Immunosuppressive Agents