title: Cellular reactive oxygen species inhibitory constituents of Hypericum thasium Griseb.
abstract: The phytochemical investigation of the ethyl acetate extract of Hypericum thasium has led to the characterization of four benzophenone derivatives 1-4, a known benzophenone 5 and four known flavonoids, quercetin (6), quercitrin (7), isoquercetin (8), and 3, 8''-biapigenin (9). Lucigenin- and luminal-based chemiluminescence assays were employed to monitor the inhibitory activity of these compounds towards the production of reactive oxygen species (ROS) by human polymorphoneutrophils (PMNs). The assay results showed that benzophenones 1 and 3 are extracellular inhibitors of ROS production, while flavonoids 6, 8, and 9 can modulate intracellular ROS production.
authors.affiliation: Department of Chemistry, Faculty of Science and Arts, Trakya University, Edirne 22030, Turkey.
authors.forename: Ozlem
authors.initials: O
authors.lastname: Demirkiran
authors.forename: M
authors.initials: M
authors.lastname: Ahmed Mesaik
authors.forename: Hayrettin
authors.initials: H
authors.lastname: Beynek
authors.forename: Ahmed
authors.initials: A
authors.lastname: Abbaskhan
authors.forename: M
authors.initials: M
authors.lastname: Iqbal Choudhary
mesh_terms: D020902:Hypericum / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D017382:Reactive Oxygen Species / Q000737:chemistry*
chemical_list: D017382:Reactive Oxygen Species