title: [Tobacco smoke exposure levels and lipide profile].
abstract: Toxic tobacco smoke exposure to human organism is strictly related to progress of atherosclerosis changes. One of the mechanisms of these effects is a change of blood lipoprotein fraction concentrations. The concentrations of the lipid profile parameters (TCL, HDL, LDL, TG) and the chosen biomarkers (urine cotinine and 1-hydroxypyrene and blood carboxyhaemoglobine) were determined. It was studied whether the procedure of the groups determination (nonsmokers, passive and active smokers) affect the calculated average values of lipid profile parameters. The role of the applied biomarkers for the detection of the effects related to the tobacco smoke exposure is also discussed. It is concluded that there is no difference among the lipid profiles of passive smokers and nonsmokers. Cigarette smoking increases and lowers the TG and HDL concentrations, respectively. Urine cotinine seems to be the best indicator of tobacco smoke exposure among three chosen biomarkers. Study subjects were 300 male and female volunteers.
authors.affiliation: Zakład Chemii Ogólnej i Nieorganicznej, Slaski Uniwersytet Medyczny w Katowicach. wzdanch@sum.katowice.pl
authors.forename: Wioleta
authors.initials: W
authors.lastname: Zielińska-Danch
authors.forename: Jan
authors.initials: J
authors.lastname: Czogała
authors.forename: Andrzej
authors.initials: A
authors.lastname: Sobczak
authors.forename: Wioleta
authors.initials: W
authors.lastname: Grela
authors.forename: Wojciech
authors.initials: W
authors.lastname: Gnyp
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D050356:Lipid Metabolism / Q000502:physiology*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000378:metabolism*; D014028:Tobacco Smoke Pollution; D014280:Triglycerides / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008075:Lipoproteins, HDL; D014028:Tobacco Smoke Pollution; D014280:Triglycerides