title: Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome.
abstract: PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, adenitis) is a benign sporadic syndrome of unknown cause. We report 2 siblings diagnosed with this syndrome. The second case started crisis simultaneously with recurrence of crisis after a 3-year free interval in her brother. This temporal relation suggests environmental factor acting in genetically predisposed children.
authors.affiliation: Pediatrics Department, Infectious Disease Division, Hospital Santa Maria, Lisboa, Portugal. i_sampaio@yahoo.com
authors.forename: Isabel Cristina Ramos Melo
authors.initials: IC
authors.lastname: Sampaio
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Rodrigo
authors.forename: José Gonçalo Duque Pereira
authors.initials: JG
authors.lastname: Monteiro Marques
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D005335:Fever of Unknown Origin / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008199:Lymphadenitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D010507:Periodicity; D010612:Pharyngitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D035781:Siblings; D013281:Stomatitis, Aphthous / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D013577:Syndrome
chemical_list: D005938:Glucocorticoids; D011241:Prednisone