Elevated plasma level of soluble F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) in hypertension.
BACKGROUND
The F11 receptor (F11R, also known as junctional adhesion molecule A (JAM-A)) plays a role in the development of hypertension in rat. Genetic variants in the human F11R gene were demonstrated to influence systolic blood pressure. In the present study, we investigated the relationship between F11R and hypertension by examining the levels of a circulating soluble form of F11R (sF11R) in hypertensive patients.


METHODS
Plasma sF11R was measured by enzyme-linked immunosorbent assay in 152 hypertensive and 166 normotensive subjects in whom seven tagging single-nucleotide polymorphisms (SNPs) in the F11R gene had been genotyped.


RESULTS
Plasma sF11R levels were significantly higher in hypertensive subjects than in normotensive subjects (median (interquartile) range): 162.8 (85.5-293.2) vs. 116.5 (74.1-194.8) pg/ml, P = 0.004), which remained significantly higher after adjusting for age, sex, body mass index (BMI), and homeostasis model assessment of insulin resistance (HOMA-IR) (P = 0.028). In stepwise multiple logistic regression, sF11R level (log-transformed) (P = 0.040), triglycerides (log-transformed) (P = 0.024), and HOMA-IR (log-transformed) (P < 0.001) were independently associated with hypertension. Plasma sF11R level correlated with systolic and diastolic blood pressures (r = 0.15, P < 0.001, and r = 0.13, P = 0.024, respectively). In stepwise multiple linear regression, hypertension (P = 0.013) and fibrinogen levels (P = 0.027) were significant independent predictors of sF11R level. A seven-locus haplotype, present in 2.1% of the subjects, was associated with higher sF11R level (P = 0.024).


CONCLUSIONS
These results further support a role of F11 receptor in the pathophysiology of human hypertension.
Ong
Kwok Leung
KL
Department of Medicine, University of Hong Kong, Hong Kong, People's Republic of China.
Leung
Raymond Y H
RY
Babinska
Anna
A
Salifu
Moro O
MO
Ehrlich
Yigal H
YH
Kornecki
Elizabeth
E
Wong
Louisa Y F
LY
Tso
Annette W K
AW
Cherny
Stacey S
SS
Sham
Pak Chung
PC
Lam
Tai Hing
TH
Lam
Karen S L
KS
Cheung
Bernard M Y
BM
D000368:Aged; D001794:Blood Pressure / Q000235:genetics; D015815:Cell Adhesion Molecules / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000235:genetics*; D007333:Insulin Resistance / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000097:blood*; D012044:Regression Analysis
D015815:Cell Adhesion Molecules; C407243:F11R protein, human; D011956:Receptors, Cell Surface