Effect of a gluten-free diet on bone mineral density in children with celiac disease.
OBJECTIVE
The aim of the study was to assess the evolution of bone mineral density (BMD) in children with celiac disease and to evaluate the effect of a gluten-free diet (GFD).


METHODS
Altogether, 44 children (31 girls and 13 boys) were followed-up. BMD was measured by dual-energy X-ray absorptiometry of the lumbar spine (Hologic QDR 4500). Results are expressed as absolute values for BMD, and as Z scores for chronological age (BMD/CA) and bone age (BMD/BA). Patients were divided into two groups according to whether they followed a diet without (n=34) or with (n=10) gluten for at least 1 year. All patients were clinically free of symptoms at the end of the follow-up.


RESULTS
At inclusion, 26 patients (59%) were delayed in bone age, 17 children (38%) had a BMD/CA< or =1 S.D. and six (13.6%) had a BMD/CA< or =2 S.D., whereas nine children (20%) had a BMD/BA< or =1 S.D. and three (6.8%) had a BMD/BA< or =2 S.D. During the follow-up, the BMD increase was greater in the GFD group, as determined by the BMD/CA/year (+0.05+/-0.3 vs -0.34+/-0.4 S.D.; P<0.01) and BMD/BA/year (-0.02+/-0.4 vs -0.4+/-0.6 S.D.; P<0.05). The gain in BMD/BA was smaller in the GFD group because of their need to catch up in bone maturation.


CONCLUSIONS
Celiac children not following a GFD show delays in both bone maturation and mineralization. This prospective study confirms the importance of maintaining a GFD in children with celiac disease until the end of skeletal mineralization even in asymptomatic patients following a non-restricted diet.
Heyman
R
R
Department of Child and Adolescent Medicine, Hospital Sud, 16, boulevard de Bulgarie, BP 90347, 35203 Rennes cedex 2, France.
Guggenbuhl
P
P
Corbel
A
A
Bridoux-Henno
L
L
Tourtelier
Y
Y
Balençon-Morival
M
M
de Kerdanet
M
M
Dabadie
A
A
D015502:Absorptiometry, Photon; D000293:Adolescent; D000365:Age Determination by Skeleton; D015519:Bone Density; D001846:Bone Development; D001851:Bone Diseases, Metabolic / Q000178:diet therapy / Q000209:etiology; D002446:Celiac Disease / Q000150:complications / Q000175:diagnosis / Q000178:diet therapy*; D002648:Child; D002675:Child, Preschool; D055050:Diet, Gluten-Free; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae; D008297:Male; D011446:Prospective Studies