Asymmetric hydroboration of 1,1-disubstituted alkenes.
A breakthrough in the asymmetric hydroboration of notoriously difficult 1,1-disubstituted alkenes using a new family of highly effective hydroboration reagents is described (see scheme). The intermediate boranes can be oxidized to alcohols or used in Suzuki-Miyaura cross-coupling reactions.
Thomas
Stephen P
SP
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
Aggarwal
Varinder K
VK
D000438:Alcohols / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry*; D001880:Boranes / Q000737:chemistry*; D002384:Catalysis; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; D000475:Alkenes; D001880:Boranes; D012238:Rhodium