In vitro imaging and in vivo liver targeting with carbohydrate capped quantum dots.
PEGylated quantum dots (QDs) capped with d-mannose, d-galactose, and d-galactosamine have been synthesized. The stable, high quantum yield fluorescence of QDs was exploited to study specific carbohydrate-protein interactions in vitro and in vivo.
Kikkeri
Raghavendra
R
Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Str. 10, 8093 Zurich, Switzerland.
Lepenies
Bernd
B
Adibekian
Alexander
A
Laurino
Paola
P
Seeberger
Peter H
PH
D000818:Animals; D037263:Asialoglycoprotein Receptor / Q000378:metabolism; D045744:Cell Line, Tumor; D005434:Flow Cytometry; D005688:Galactosamine / Q000737:chemistry*; D005690:Galactose / Q000737:chemistry*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008358:Mannose / Q000737:chemistry*; D051379:Mice; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*; D045663:Quantum Dots
D037263:Asialoglycoprotein Receptor; D011092:Polyethylene Glycols; D005688:Galactosamine; D008358:Mannose; D005690:Galactose