Practical synthesis of 5-aryl-3-alkylsulfonyl-phenol and 5-aryl-3-arylsulfonyl-phenol libraries.
A straightforward and cost-effective synthesis of 5-aryl-3-alkylsulfonyl-phenols by a sequential scaffold derivatization strategy has been developed. The procedure is suitable for parallel synthesis of small libraries around the biphenyl privileged core having an unusual 1,3,5-substitution pattern. The synthesis is exemplified by a pilot library of 30 compounds.
Jeges
Gyorgy
G
AMRI, Zahony u 7, 1031 Budapest, Hungary. gyorgy.jeges@amriglobal.com
Nagy
Tamas
T
Meszaros
Tamas
T
Kovacs
Jozsef
J
Dorman
Gyorgy
G
Kowalczyk
Agnieszka
A
Goodnow
Robert A
RA
D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
D010636:Phenols; D054852:Small Molecule Libraries; D013450:Sulfones