title: Mononuclear copper(II)-superoxo complexes that mimic the structure and reactivity of the active centers of PHM and DbetaM.
abstract: Mononuclear copper(II)-superoxo complexes 2(X)-OO(*) having triplet (S = 1) ground states were obtained via reaction of O(2) with the copper(I) starting materials 1(X) supported by tridentate ligands L(X) [1-(2-p-X-phenethyl)-5-(2-pyridin-2-ylethyl)-1,5-diazacyclooctane; X = CH(3), H, NO(2)] in various solvents. The superoxo complexes 2(X)-OO(*) mimic the structure [tetrahedral geometry with an end-on (eta(1))-bound O(2)(*-)] and the aliphatic C-H bond activation chemistry of peptidylglycine alpha-hydroxylating monooxygenase and dopamine beta-monooxygenase.
authors.affiliation: Department of Chemistry, Graduate School of Science, Osaka City University, 3-3-138 Sugimoto, Sumiyoshi-ku, Osaka 558-8585, Japan.
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kunishita
authors.forename: Minoru
authors.initials: M
authors.lastname: Kubo
authors.forename: Hideki
authors.initials: H
authors.lastname: Sugimoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Ogura
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Sato
authors.forename: Takeji
authors.initials: T
authors.lastname: Takui
authors.forename: Shinobu
authors.initials: S
authors.lastname: Itoh
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D020134:Catalytic Domain; D003300:Copper / Q000737:chemistry*; D034242:Cyclooctanes / Q000737:chemistry; D004299:Dopamine beta-Hydroxylase / Q000737:chemistry* / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D008024:Ligands; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013481:Superoxides / Q000737:chemistry*
chemical_list: D034242:Cyclooctanes; D008024:Ligands; D009097:Multienzyme Complexes; D009942:Organometallic Compounds; D013481:Superoxides; D003300:Copper; D006899:Mixed Function Oxygenases; D004299:Dopamine beta-Hydroxylase; C035189:peptidylglycine monooxygenase