title: Influence of HBV gene heterogeneity on the failure of immunization with HBV vaccines in eastern China.
abstract: The influence of hepatitis B virus (HBV) gene heterogeneity on the failure of HBV vaccination in eastern China remains unknown. Here, we assigned 78 hepatitis B surface antigen (HBsAg)-carrier mothers to two groups: 41 mothers from whom transmission of HBV to their children was successfully prevented and 37 mothers whose children were HBsAg positive 1 year after HBV vaccination. The DNA loads in mothers of the failure group (4.17E + 07 copies/ml) were significantly higher than those in the success group (8.40E + 06 copies/ml). However, no difference was found in the S gene mutation rate and genotypes between the groups. Interestingly, Thr123Ala and Gly145Arg were observed only in failure-group mothers, whereas Thr126Asn, Thr126Ser, Thr143Asn, Asp144Gly, and Asp144Ala were seen in the success group. Thus, high viral load is an important risk factor for HBV vaccination failure, which is correlated with the positions of mutations in the S gene, but not with mutant frequencies or genotypes.
authors.affiliation: Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, 310003, Hangzhou, People's Republic of China.
authors.forename: She-Lan
authors.initials: SL
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Dong
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Min-Wei
authors.initials: MW
authors.lastname: Li
authors.forename: Jian-er
authors.initials: JE
authors.lastname: Wo
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Lu
authors.forename: Zhen-Juan
authors.initials: ZJ
authors.lastname: Chen
authors.forename: Yong-Zhong
authors.initials: YZ
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Ruan
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics / Q000276:immunology; D002675:Child, Preschool; D002681:China; D005260:Female; D006509:Hepatitis B / Q000276:immunology* / Q000635:transmission / Q000821:virology*; D006514:Hepatitis B Surface Antigens / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D020125:Mutation, Missense / Q000276:immunology; D011110:Polymorphism, Genetic; D019562:Viral Load
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines