Sodium valproate as a cause of recurrent transudative pleural effusion: a case report.
BACKGROUND
There are few reported cases of neutrophilic pleural effusions associated with valproic acid therapy. Most of them are of eosinophilic exudates with or without blood eosinophilia.


METHODS
This case study describes a 70-year-old man with recurrent episodes of eosinophilic transudative pleural effusions associated with sodium valproate treatment. The recurrence of effusion after re-administration of the drug is strongly suggestive of an association between them. To the best of our knowledge, this is the first reported case with a pleural effusion with these characteristics caused by sodium valproate.


CONCLUSIONS
This is the first report in the literature, with a full understanding of the etiology but with an unknown drug mechanism. This case report is of interest to different medical specialists (such as pulmonologists, neurologists, cardiologists) and pharmacologists.
Tryfon
Stavros
S
1st Pulmonary Clinic, G,H, "G, Papanikolaou", Thessaloniki, Greece. strifon@med.auth.gr.
Saroglou
Maria
M
Kazanas
Kosmas
K
Mermigkis
Charalambos
C
Psathakis
Kostas
K
Galanis
Nikolaos
N