New susceptibility locus for coronary artery disease on chromosome 3q22.3.
We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
Erdmann
Jeanette
J
Medizinische Klinik II, Universität zu Lübeck, 23538 Lübeck, Germany. j.erdmann@cardiogenics.eu
Grosshennig
Anika
A
Braund
Peter S
PS
König
Inke R
IR
Hengstenberg
Christian
C
Hall
Alistair S
AS
Linsel-Nitschke
Patrick
P
Kathiresan
Sekar
S
Wright
Ben
B
Trégouët
David-Alexandre
DA
Cambien
Francois
F
Bruse
Petra
P
Aherrahrou
Zouhair
Z
Wagner
Arnika K
AK
Stark
Klaus
K
Schwartz
Stephen M
SM
Salomaa
Veikko
V
Elosua
Roberto
R
Melander
Olle
O
Voight
Benjamin F
BF
O'Donnell
Christopher J
CJ
Peltonen
Leena
L
Siscovick
David S
DS
Altshuler
David
D
Merlini
Piera Angelica
PA
Peyvandi
Flora
F
Bernardinelli
Luisa
L
Ardissino
Diego
D
Schillert
Arne
A
Blankenberg
Stefan
S
Zeller
Tanja
T
Wild
Philipp
P
Schwarz
Daniel F
DF
Tiret
Laurence
L
Perret
Claire
C
Schreiber
Stefan
S
El Mokhtari
Nour Eddine
NE
Schäfer
Arne
A
März
Winfried
W
Renner
Wilfried
W
Bugert
Peter
P
Klüter
Harald
H
Schrezenmeir
Jürgen
J
Rubin
Diana
D
Ball
Stephen G
SG
Balmforth
Anthony J
AJ
Wichmann
H-Erich
HE
Meitinger
Thomas
T
Fischer
Marcus
M
Meisinger
Christa
C
Baumert
Jens
J
Peters
Annette
A
Ouwehand
Willem H
WH
Deloukas
Panos
P
Thompson
John R
JR
Ziegler
Andreas
A
Samani
Nilesh J
NJ
Schunkert
Heribert
H
D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3; D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005858:Germany; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D018631:ras Proteins / Q000235:genetics
C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; C109523:MRAS protein, human; D018631:ras Proteins