title: Microwave-assisted synthesis of N-substituted cyclic imides and their evaluation for anticancer and anti-inflammatory activities.
abstract: A number of N-substituted cyclic imides 3a-e, 5a-e, 7a-d, and 9a-e have been synthesized in very high yields, by condensation of various diacids 2, 4, 6, and 8 with different amines under microwave irradiation. These compounds were screened for anticancer and anti-inflammatory activities, and compounds 3c, 3e, 5c, 9c, and 9d exhibited anticancer activity against colon (COLO 205) cancer better than 5-fluorouracil and mitomycin-C, and compound 9b exhibited anti-inflammatory activity better than standard drug phenyl butazone.
authors.affiliation: Department of Chemistry, Indian Institute of Technology-Roorkee, Roorkee, Uttaranchal 247667, India.
authors.forename: Sham M
authors.initials: SM
authors.lastname: Sondhi
authors.forename: Reshma
authors.initials: R
authors.lastname: Rani
authors.forename: Partha
authors.initials: P
authors.lastname: Roy
authors.forename: S K
authors.initials: SK
authors.lastname: Agrawal
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000528:radiation effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000528:radiation effects / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004487:Edema / Q000188:drug therapy; D005260:Female; D006801:Humans; D007094:Imides / Q000138:chemical synthesis* / Q000528:radiation effects / Q000627:therapeutic use; D008297:Male; D008872:Microwaves; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D007094:Imides