title: A system biology approach to understand functional activity of cell communication systems.
abstract: Systems Biology is the quantitative analysis of dynamic interactions among several components of a biochemical system, aiming at an understanding of the behavior of the system as a whole. From an experimental perspective, systems biology is a suitable tool to support the biologist in the process of hypotheses generation and the efficient design of experiments. In this chapter, we discuss the elements of a systems biology methodology based on the interaction between experimental biologists and theoreticians. We, furthermore, show the use of such a methodology in a case study, analyzing receptor and transcription factor modulation affecting the responsiveness of the JAK2/STAT5 pathway.
authors.affiliation: Department of Computer Science, University of Rostock, 18051 Rostock, Germany.
authors.forename: Julio
authors.initials: J
authors.lastname: Vera
authors.forename: Olaf
authors.initials: O
authors.lastname: Wolkenhauer
mesh_terms: D002138:Calibration; D002450:Cell Communication; D003198:Computer Simulation; D053614:Janus Kinase 2 / Q000378:metabolism; D008954:Models, Biological; D017711:Nonlinear Dynamics; D017467:Receptors, Erythropoietin / Q000378:metabolism; D050799:STAT5 Transcription Factor / Q000378:metabolism; D015398:Signal Transduction; D049490:Systems Biology / Q000379:methods*
chemical_list: D017467:Receptors, Erythropoietin; D050799:STAT5 Transcription Factor; D053614:Janus Kinase 2