title: Community-based study on CKD subjects and the associated risk factors.
abstract: BACKGROUND
  The study was performed to investigate the prevalence, awareness and the risk factors of chronic kidney disease (CKD) in the community population in Shanghai, China.
  
  
  METHODS
  A total of 2596 residents were randomly recruited from the community population in Shanghai, China. All were screened for albuminuria, haematuria, morning spot urine albumin-to-creatinine ratio and renal function. Serum creatinine, uric acid, cholesterol, triglyceride and haemoglobin were assessed. A simplified MDRD equation was used to estimate the glomerular filtration rate (eGFR). All studied subjects were screened by kidney ultrasound. Haematuria, if present in the morning spot urine dipstick test, was confirmed by microscopy. The associations among the demographic characteristics, health characteristics and indicators of kidney damage were examined.
  
  
  RESULTS
  Two thousand five hundred and fifty-four residents (n = 2554), after giving informed consent and with complete data, were entered into this study. Albuminuria and haematuria were detected in 6.3% and 1.2% of all the studied subjects, respectively, whereas decreased kidney function was found in 5.8% of all studied subjects. Approximately 11.8% of subjects had at least one indicator of kidney damage. The rate of awareness of CKD was 8.2%. The logistic regression model showed that age, central obesity, hypertension, diabetes, anaemia, hyperuricaemia and nephrolithiasis each contributed to the development of CKD.
  
  
  CONCLUSIONS
  This is the first Shanghai community-based epidemiological study data on Chinese CKD patients. The prevalence of CKD in the community population in Shanghai is 11.8%, and the rate of awareness of CKD is 8.2%. All the factors including age, central obesity, hypertension, diabetes, anaemia, hyperuricaemia and nephrolithiasis are positively correlated with the development of CKD in our studied subjects.
authors.affiliation: Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, People's Republic of China. chen-nan@medmail.com.cn
authors.forename: Nan
authors.initials: N
authors.lastname: Chen
authors.forename: Weiming
authors.initials: W
authors.lastname: Wang
authors.forename: Yanping
authors.initials: Y
authors.lastname: Huang
authors.forename: Pingyan
authors.initials: P
authors.lastname: Shen
authors.forename: Daoling
authors.initials: D
authors.lastname: Pei
authors.forename: Haijin
authors.initials: H
authors.lastname: Yu
authors.forename: Hao
authors.initials: H
authors.lastname: Shi
authors.forename: Qianying
authors.initials: Q
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yilun
authors.initials: Y
authors.lastname: Lv
authors.forename: Qishi
authors.initials: Q
authors.lastname: Fan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult