title: [Metabolic syndrome].
abstract: Metabolic syndrome, which is consisted of hypertension, dyslipidemia and impaired glucose tolerance, is one of the most significant lifestyle-related disorders that lead to cardiovascular diseases. Among many upstream factors that are related to metabolic syndrome, obesity, especially visceral obesity, plays an essential role in its pathogenesis. In recent studies, possible mechanisms which connect obesity to metabolic syndrome have been elucidated, such as inflammation, abnormal secretion of adipokines and mitochondrial dysfunction. In this review, we focus on the relationship between obesity and metabolic syndrome; and illustrate how visceral obesity contributes to, and how the treatments for obesity act on metabolic syndrome.
authors.affiliation: Department of Internal Medicine, School of Medicine, Keio University.
authors.forename: Masanori
authors.initials: M
authors.lastname: Mitsuishi
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Miyashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
mesh_terms: D006801:Humans; D050152:Intra-Abdominal Fat; D024821:Metabolic Syndrome / Q000209:etiology*; D009765:Obesity / Q000150:complications / Q000628:therapy