Long-term follow-up study of patients with refractory obsessive-compulsive disorder.
The authors prospectively followed patients with treatment-resistant obsessive-compulsive disorder (OCD). Between 1988 and 1995, 56 patients with a history of inadequate response to oral clomipramine received 14 infusions of intravenous clomipramine. The follow-up period ranged from 4 to 11 years after treatment. Of the 44 subjects interviewed at follow-up, 70.5% had current OCD and 29.5% had sub-threshold OCD. Almost half reported feeling much improved or very much improved compared to their state prior to treatment with intravenous clomipramine.
Ross
Stephen
S
Department of Adult Psychiatry, New York University, NY, USA. Stephen.ross@nyumc.org
Fallon
Brian A
BA
Petkova
Eva
E
Feinstein
Suzanne
S
Liebowitz
Michael R
MR
D000293:Adolescent; D000328:Adult; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000627:therapeutic use; D002997:Clomipramine / Q000008:administration & dosage / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007275:Injections, Intravenous; D007406:Interview, Psychological; D008297:Male; D001523:Mental Disorders / Q000150:complications / Q000523:psychology; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D011795:Surveys and Questionnaires; D055815:Young Adult
D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine