title: Kounis syndrome: two extraordinary cases.
abstract: Acute myocardial infarction occurring during the course of an allergic reaction constitutes the Kounis syndrome. This syndrome is caused by inflammatory mediators released mainly from activated mast cells and the interrelated via bidirectional stimuli macrophages and T-lymphocytes. Since activated mast cells abound at the areas of plaque erosion or rupture in patients suffering from acute myocardial infarction a common pathway between allergic and non allergic coronary events seems to exist. Two cases of this syndrome are described, the first following nicorette transdermal application and subsequent finger pricking by fish bone and the second after ciprofloxacin administration.
authors.forename: George
authors.initials: G
authors.lastname: Almpanis
authors.forename: Simos
authors.initials: S
authors.lastname: Siahos
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Karogiannis
authors.forename: Andreas
authors.initials: A
authors.lastname: Mazarakis
authors.forename: Constantinos
authors.initials: C
authors.lastname: Niarchos
authors.forename: George N
authors.initials: GN
authors.lastname: Kounis
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Kounis
mesh_terms: D000369:Aged, 80 and over; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects; D002939:Ciprofloxacin / Q000009:adverse effects; D003329:Coronary Vasospasm / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005399:Fishes; D006801:Humans; D006967:Hypersensitivity / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin