Alstiphyllanines A-D, indole alkaloids from Alstonia macrophylla.
Four new alkaloids, alstiphyllanines A-D (1-4), were isolated from Alstonia macrophylla, and their structures were determined by MS and 2D NMR analyses. Alkaloids 1-4 showed moderate antiplasmodial activity against Plasmodium falciparum and vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
Hirasawa
Yusuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
Arai
Hiroko
H
Zaima
Kazumasa
K
Oktarina
Rice
R
Rahman
Abdul
A
Ekasari
Wiwied
W
Widyawaruyanti
Aty
A
Indrayanto
Gunawan
G
Zaini
Noor Cholies
NC
Morita
Hiroshi
H
D031051:Alstonia / Q000737:chemistry*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects; D004727:Endothelium / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D010656:Phenylephrine / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology
D000962:Antimalarials; D026121:Indole Alkaloids; D014665:Vasodilator Agents; D010656:Phenylephrine