Mycoplasma lipoproteins and Toll-like receptors.
Mycoplasmas, the smallest free-living, self-replicating bacteria with diameters of 200 to 800 nm, have been reported to be associated with human diseases. It is well known that the mycoplasma lipoprotein/peptide is able to modulate the host immune system, whose N-terminal structure is an important factor in inducing immunity and distinguishing Toll-like receptors (TLRs). However, there is still no clear elucidation about the pathogenic mechanism of mycoplasma lipoprotein/peptide and the signaling pathway. Some researchers have focused on understanding the structures of these proteins and the relationships between their structure and biological function. This review provides an update on the research in this field.
Zuo
Ling-ling
LL
Institute of Pathogenic Biology, University of South China, Hengyang, China.
Wu
Yi-mou
YM
You
Xiao-xing
XX
D008074:Lipoproteins / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D009174:Mycoplasma / Q000737:chemistry* / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000737:chemistry* / Q000378:metabolism*
D008074:Lipoproteins; D051193:Toll-Like Receptors