A comparison of urinary neutrophil gelatinase-associated lipocalin in patients undergoing on- versus off-pump coronary artery bypass graft surgery.
OBJECTIVE
The purpose of this study was to compare urinary neutrophil gelatinase-associated lipocalin (NGAL) levels in off-pump and on-pump coronary artery bypass graft (CABG) surgery.


METHODS
A matched cohort study.


METHODS
A tertiary university hospital.


METHODS
Thirty adult patients undergoing CABG surgery without cardiopulmonary bypass (off-pump) matched to 30 patients with on-pump CABG surgery by age, preoperative serum creatinine, Parsonnet score, ejection fraction, body mass index, and number of coronary artery grafts.


METHODS
None, observational.


RESULTS
Urinary NGAL, a novel, highly sensitive biomarker for renal injury, was measured before and immediately after surgery and then 3, 18, and 24 hours later. There were no differences in urinary NGAL at any time point between patients subjected to off-pump or on-pump CABG surgery; the peak urinary NGAL in patients who underwent off-pump CABG surgery was 94.7 +/- 30.9 ng/mL compared with 122.7 +/- 57.0 ng/mL in patients with on-pump CABG surgery (p = 0.6). Peak serum creatinine and the incidence of acute kidney injury also were not different between the groups.


CONCLUSIONS
Urinary NGAL was not different in patients undergoing off-pump and on-pump CABG surgery despite a very good match between the groups with respect to pre- and intraoperative risk factors.
Wagener
Gebhard
G
Department of Anesthesiology, College of Physicians and Surgeons, New York, NY, USA.
Gubitosa
Gina
G
Wang
Shuang
S
Borregaard
Niels
N
Kim
Mihwa
M
Lee
H Thomas
HT
D000209:Acute-Phase Proteins / Q000652:urine*; D000368:Aged; D015415:Biomarkers; D015992:Body Mass Index; D015331:Cohort Studies; D001026:Coronary Artery Bypass; D047549:Coronary Artery Bypass, Off-Pump; D003404:Creatinine / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015151:Immunoblotting; D007677:Kidney Function Tests; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D008297:Male; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012307:Risk Factors; D013318:Stroke Volume / Q000502:physiology
D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine