title: [The investigation of the relationship between the phenotypes of 46, XX males and the SRY gene].
abstract: OBJECTIVE
  To investigate the relationship between the phenotypes in XX male patients and the sex determining region(SRY) gene.
  
  
  METHODS
  Multiple polymerase chain reactions were carried out in 6 male patients with karyotype of 46, XX, and then the PCR products were sequenced directly.
  
  
  RESULTS
  Three cases of male infertility were positive for the SRY gene without evident malformation in their extra genitalia, while 3 cases with testes were negative for the SRY gene, with evident malformation in their extra genitalia.
  
  
  CONCLUSIONS
  The SRY gene is key in sex determination and development, yet there might be other important genes involved.
authors.affiliation: Genetics Laboratory, the Affiliated Shengjing Hospital, China Medical University, Shenyang, Liaoning, 110004 PR China. wangyueping12@tom.com
authors.forename: Yue-ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Yun-jing
authors.initials: YJ
authors.lastname: Zhao
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ruan
authors.forename: Yao-hua
authors.initials: YH
authors.lastname: Ji
authors.forename: Ming-ge
authors.initials: MG
authors.lastname: Hao
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Jiang
mesh_terms: D000328:Adult; D002675:Child, Preschool; D024282:Genes, sry / Q000235:genetics*; D005837:Genitalia, Male / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D012729:Sex Chromosome Aberrations; D025064:Sex Chromosome Disorders / Q000235:genetics* / Q000473:pathology