title: Surveillance of acute bacterial meningitis among children admitted to a district hospital in rural Mozambique.
abstract: BACKGROUND
  Acute bacterial meningitis (ABM) remains an important cause of mortality among African children. Epidemiologic data with regard to ABM infection are necessary for prioritizing public health interventions.
  
  
  METHODS
  We strengthened hospital-based surveillance of ABM among children admitted to Manhiça District Hospital (Maputo, Mozambique). Cerebrospinal fluid (CSF) samples were collected from children admitted to the hospital who met clinical criteria of ABM. Laboratory determinations were performed. Clinical information and outcome of cases were recorded.
  
  
  RESULTS
  During the first 12 months of surveillance, which began in January 2006, CSF samples were collected from 642 children <15 years of age with suspected meningitis (18% of all pediatric patients admitted to the hospital during that time). ABM was confirmed in 43 (7%) of the 642 cases. Haemophilus influenzae type b (Hib) (14 cases), pneumococcus (9 cases), and meningococcus (7 cases) represented approximately 70% of confirmed cases. Four of the 9 pneumococci were serotypes covered by the 7-valent pneumococcal conjugate vaccine. The case fatality rate among patients with ABM was 24% (8 of 33 with known outcome); an additional 8 patients left the hospital before discharge. The incidence of ABM was 85 per 100,000 population, which peaked at 2-12 months of age at 1078 cases per 100,000 population. All 9 pneumococci isolates were susceptible to chloramphenicol, and 8 were susceptible to penicillin (the additional 1 had intermediate resistance). For the 10 Hib isolates tested, only 1 was susceptible to chloramphenicol, and 5 were susceptible to ampicillin.
  
  
  CONCLUSIONS
  These data reinforce the importance of ABM as a cause of hospital admission and death in rural sub-Saharan Africa. Most observed ABM cases could have been prevented by current pneumococcal and Hib conjugate vaccines.
authors.affiliation: Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic/Institut d'Investigacions Biomèdiques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain. aroca@clinic.ub.es
authors.forename: A
authors.initials: A
authors.lastname: Roca
authors.forename: Q
authors.initials: Q
authors.lastname: Bassat
authors.forename: L
authors.initials: L
authors.lastname: Morais
authors.forename: S
authors.initials: S
authors.lastname: Machevo
authors.forename: B
authors.initials: B
authors.lastname: Sigaúque
authors.forename: C
authors.initials: C
authors.lastname: O'Callaghan
authors.forename: T
authors.initials: T
authors.lastname: Nhamposa
authors.forename: E
authors.initials: E
authors.lastname: Letang
authors.forename: I
authors.initials: I
authors.lastname: Mandomando
authors.forename: D
authors.initials: D
authors.lastname: Nhalungo
authors.forename: Ll
authors.initials: L
authors.lastname: Quintó
authors.forename: P
authors.initials: P
authors.lastname: Alonso
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000145:classification / Q000302:isolation & purification; D002555:Cerebrospinal Fluid / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006767:Hospitals, District; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000453:epidemiology* / Q000382:microbiology / Q000401:mortality; D008826:Microbial Sensitivity Tests; D009073:Mozambique / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents