title: Congenital granular cell epulis presents an immunohistochemical profile that distinguishes it from the granular cell tumor of the adult.
abstract: Congenital granular cell epulis (CGCE), a rare benign lesion arising from the mucosa of the alveolar ridges of the jaws in newborns, has a clinical course characterized by lack of further growth after birth. Histomorphologically, it resembles a granular cell tumor (GCT) of the adult. The histogenesis of this lesion is unclear. We submitted a series of five CGCEs to a large panel of antibodies in order to trace the origin of the constituent granular cells. The resultant immunohistochemical profile showed positivity of these cells to vimentin, NKI/C3, and PGP9.5. This does not confirm any particular cell type for the histogenetic origin of CGCE but may rather reflect a local metabolic or reactive change, providing supporting evidence that the lesion is of a non-neoplastic nature. In addition, the granular cells were non-reactive for S-100, NGFR/p75, and inhibin-alpha, which further contributes to the distinction between a CGCE and the adult GCT.
authors.affiliation: Department of Oral Pathology and Oral Medicine, Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel. mvered@post.tau.ac.il
authors.forename: Marilena
authors.initials: M
authors.lastname: Vered
authors.forename: Alex
authors.initials: A
authors.lastname: Dobriyan
authors.forename: Amos
authors.initials: A
authors.lastname: Buchner
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000032:analysis*; D019070:Cell Lineage; D005887:Gingival Neoplasms / Q000151:congenital* / Q000378:metabolism* / Q000473:pathology; D016586:Granular Cell Tumor / Q000151:congenital* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D010733:Phosphoglucomutase / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D010733:Phosphoglucomutase; D009418:S100 Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C488050:PGM1 protein, human