Neuroendocrine regulatory peptide-1 and -2: novel bioactive peptides processed from VGF.
Neuroendocrine regulatory peptides (NERP)-1 and NERP-2 are derived from distinct regions of VGF, a neurosecretory protein that was originally identified as a product of a nerve growth factor-responsive gene in rat PC12 cells. The amino acid length of human NERP-1 is 26, and that of rat NERP-1 is 25. Human and rat NERP-2 are both 38 amino acid peptides. NERPs colocalize with vasopressin in the storage granules of the paraventricular and supraoptic nuclei in the hypothalamus of both rats and humans. Administration of NERPs suppresses hypertonic saline- or angiotensin II-induced vasopressin release from the hypothalamus and pituitary. Thus, VGF is a precursor of multiple bioactive peptides with diverse neuroendocrine functions, and NERPs are novel hypothalamic peptides involved in the control of body fluid homeostasis by regulating vasopressin release.
Toshinai
K
K
Neurology, Respirology, Endocrinology and Metabolism, Division of Internal Medicine, Faculty of Medicine, University of Miyazaki, Kiyotake, Miyazaki, 889-1692, Japan.
Nakazato
M
M
D000595:Amino Acid Sequence; D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology; D009490:Neurosecretory Systems / Q000502:physiology*; D051381:Rats; D013495:Supraoptic Nucleus / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C510637:VGF protein, human; C062040:Vgf protein, rat; C523893:neuroendocrine regulatory peptide-1, human; C523894:neuroendocrine regulatory peptide-1, rat; C523895:neuroendocrine regulatory peptide-2, human; C523896:neuroendocrine regulatory peptide-2, rat; D014667:Vasopressins; D000804:Angiotensin II