title: Successful second allogeneic stem cell transplantation in second remission induced by dasatinib in a child with Philadelphia chromosome positive acute lymphoblastic leukemia.
abstract: We report on the use of dasatinib, a second-generation bcr-abl kinase inhibitor, in a child in early relapse of Philadelphia chromosome positive acute lymphoblastic leukemia after hematopoietic stem cell transplantation. This patient benefited from the use of dasatinib obtaining of a complete molecular response which allowed a second successful transplant. Moreover, dasatinib was well tolerated in this heavily pretreated patient.
authors.affiliation: Service d'Oncologie Hématologique et de Thérapie Cellulaire, Centre Hospitalier Universitaire de Poitiers, Poitiers, France. f.millot@chu-poitiers.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Millot
authors.forename: Marie
authors.initials: M
authors.lastname: Cividin
authors.forename: Françoise
authors.initials: F
authors.lastname: Brizard
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Chomel
authors.forename: Françoise
authors.initials: F
authors.lastname: Méchinaud
authors.forename: François
authors.initials: F
authors.lastname: Guilhot
mesh_terms: D002675:Child, Preschool; D000069439:Dasatinib; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors / Q000235:genetics; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000628:therapy; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000628:therapy*; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use*; D012074:Remission Induction; D016879:Salvage Therapy; D013844:Thiazoles / Q000627:therapeutic use*; D014184:Transplantation, Homologous
chemical_list: D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D013844:Thiazoles; D016044:Fusion Proteins, bcr-abl; D000069439:Dasatinib