Precursor-directed biosynthesis of fluorinated iturin A in Bacillus spp.
Some iturin A-producing strains of Bacillus subtilis will elaborate the novel fluorinated analogue when incubated with 3-fluoro-L-tyrosine. The activity of iturin A is dependent on the D-tyrosine residue and the presence of fluorotyrosine may result in an improvement of the biological properties of this lipopeptide. The fluorinated iturin might also be used as a probe for studying its interaction with biological membranes.
Moran
Stephen
S
School of Biomolecular and Biomedical Science, Ardmore House, University College Dublin, Dublin 4, Ireland.
Rai
Dilip K
DK
Clark
Benjamin R
BR
Murphy
Cormac D
CD
D001412:Bacillus subtilis / Q000378:metabolism*; D005461:Fluorine / Q000737:chemistry; D055666:Lipopeptides; D010456:Peptides, Cyclic / Q000096:biosynthesis*; D014443:Tyrosine
D055666:Lipopeptides; D010456:Peptides, Cyclic; D005461:Fluorine; D014443:Tyrosine; C013579:iturin A