title: Haplotype diversity of 22 Y-chromosomal STRs in a southeast China population sample (Chaoshan area).
abstract: In this study, 22 Y-specific STR loci (DYS19, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS385, DYS437, DYS438, DYS439, DYS461, DYS481, DYS504, DYS505, DYS508, DYS533, DYS576, DYS588, DYS607, DYS634, and DYS643) were analyzed in 216 unrelated male individuals from southeast China (Chaoshan area) by three multiplex PCR systems. The haplotype diversity using the classical set of Y-STRs (DYS19, DYS389I/II, DYS390, DYS391, DYS392, DYS393, DYS437, DYS438, DYS439, and DYS385; PowerPlexY Systems) was 0.9908. For the same population sample, the haplotype diversity using the new sets of 11 novel Y-STRs (DYS461, DYS481, DYS504, DYS505, DYS508, DYS533, DYS576, DYS588, DYS607, DYS634, and DYS643; multiplex I and II) was 0.9917. By combining the allelic states of the 22 Y-STR loci we could construct highly informative haplotypes that allowed the discrimination of 99.1% (214 out of 216) of the samples tested and the overall haplotype diversity of 0.9999. These results, including the haplotype data at 22 Y-STR loci in the present study, provide useful information for forensic practice in the Chaoshan population in southeast China.
authors.affiliation: Key Laboratory of Evidence Science (China University of Political Science and Law), Ministry of Eduction 25 Xitucheng Road, Haidian District, Beijing 100088, PR China. shimeisen2000@yahoo.com.cn
authors.forename: Meisen
authors.initials: M
authors.lastname: Shi
authors.forename: Rufeng
authors.initials: R
authors.lastname: Bai
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Yu
authors.forename: Junyao
authors.initials: J
authors.lastname: Lv
authors.forename: Bo
authors.initials: B
authors.lastname: Hu
mesh_terms: D000483:Alleles; D002681:China; D041322:Chromosomes, Human, Y; D016172:DNA Fingerprinting; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D005843:Geography; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction