Invasive hydatidiform mole: immunohistochemical labelling of inhibin/activin subunits, Ki67, p53 and glycodelin A in a rare case.
Invasive trophoblastic mole is an extremely rare condition. Its early recognition is essential since it can transform into an invasive type of tumour. Immunohistochemistry was performed with monoclonal antibodies against inhibin-alpha, -betaA and -betaB, Ki67, p53 and glycodelin A in a rare case of accidentally diagnosed invasive trophoblastic mole. There was labelling of the inhibin/activin subunits, Ki67 and p53, while glycodelin A showed minimal immunopositivity. Therefore, since the pathological diagnosis of an invasive mole is difficult, the immunohistochemical detection of inhibin/activin subunits, Ki67, p53 and glycodelin A might be additional useful tumour markers.
Makovitzky
Josef
J
Department of Obstetrics and Gynaecology, University of Rostock, Rostock, Germany.
Radtke
Anngret
A
Shabani
Naim
N
Friese
Klaus
K
Gerber
Bernd
B
Mylonas
Ioannis
I
D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000378:metabolism*; D007150:Immunohistochemistry / Q000379:methods*; D028322:Inhibin-beta Subunits / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000378:metabolism*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D000071816:Glycodelin; D006023:Glycoproteins; D019394:Ki-67 Antigen; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D016159:Tumor Suppressor Protein p53; D028322:Inhibin-beta Subunits