"Aplosspan:" a bilayer-length, ion-selective ionophore that functions in phospholipid bilayers.
A structurally simple, novel, membrane-active ionophore has been designed, prepared, characterized, and shown to conduct Na(+), Cl(-), and carboxyfluorescein anions, probably as a dimer, across liposomal bilayers.
Wang
Wei
W
Department of Chemistry, Washington University, St. Louis, MO 63130, USA.
Li
Ruiqiong
R
Gokel
George W
GW
D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000737:chemistry; D005452:Fluoresceins / Q000737:chemistry; D007476:Ionophores / Q000737:chemistry*; D008051:Lipid Bilayers / Q000737:chemistry*; D008954:Models, Biological; D015394:Molecular Structure; D010743:Phospholipids / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry
D001713:Biphenyl Compounds; D004983:Ethanolamines; D005452:Fluoresceins; D007476:Ionophores; D008051:Lipid Bilayers; D010743:Phospholipids; C540082:aplosspan; D012965:Sodium Chloride; C045132:4-carboxyfluorescein