title: The effects of midazolam on the bispectral index after fetal expulsion in caesarean section under general anaesthesia with sevoflurane.
abstract: The effects of midazolam used with low concentration inhaled anaesthetics on the bispectral index (BIS) was investigated after fetal expulsion during caesarean section. Forty-five patients undergoing caesarean section received either normal saline (control, n = 15), or an intravenous bolus of 0.03 mg/kg (n = 15) or 0.05 mg/kg (n = 15) midazolam. Changes in BIS and maternal haemodynamics were monitored before induction, on intubation, at uterine incision, on delivery, at 3, 5 and 10 min after fetal expulsion, at subcutaneous tissue closure, at skin closure, on eye opening and at extubation. BIS values in the group that received 0.05 mg/kg midazolam were significantly lower than in the other two groups at 3, 5 and 10 min after fetal expulsion, and at subcutaneous tissue closure and skin closure. Values of BIS < 60 could only be maintained with 0.05 mg/kg midazolam and there was no delay in maternal emergence or recovery.
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Korea University Ansan Hospital, Ansan, Korea.
authors.forename: S-J
authors.initials: SJ
authors.lastname: Ok
authors.forename: W-Y
authors.initials: WY
authors.lastname: Kim
authors.forename: Y-S
authors.initials: YS
authors.lastname: Lee
authors.forename: K-G
authors.initials: KG
authors.lastname: Kim
authors.forename: H-W
authors.initials: HW
authors.lastname: Shin
authors.forename: M-S
authors.initials: MS
authors.lastname: Chang
authors.forename: J-H
authors.initials: JH
authors.lastname: Kim
authors.forename: Y-C
authors.initials: YC
authors.lastname: Park
mesh_terms: D000328:Adult; D000762:Anesthesia Recovery Period; D000768:Anesthesia, General; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008738:Methyl Ethers / Q000494:pharmacology*; D008874:Midazolam / Q000494:pharmacology*; D000077149:Sevoflurane; D016896:Treatment Outcome
chemical_list: D008738:Methyl Ethers; D000077149:Sevoflurane; D008874:Midazolam