title: Advanced squamous cell carcinoma of the oropharynx: efficacy of positron emission tomography and computed tomography for determining primary tumor response during induction chemotherapy.
abstract: BACKGROUND
  To evaluate the efficacy of fluorine-18-fluorodeoxyglucose emission tomography (FDG-PET) and CT versus endoscopy with biopsy under general anesthesia for estimating tumor volume reduction among patients treated with induction chemotherapy for advanced squamous cell carcinoma (SCC) of the oropharynx.
  
  
  METHODS
  Twelve patients with oropharyngeal SCC nested in a phase II, induction chemoradiation, organ preservation trial (University of Michigan Cancer Center 9921) underwent tumor volume reduction estimation as assessed by FDG-PET, CT, and endoscopy with biopsy.
  
  
  RESULTS
  In 9 of 12 patients, FDG-PET, CT, and endoscopy demonstrated agreement in estimation of tumor reduction. Two patients had discordant results, whereas 1 patient was inadequately evaluated with FDG-PET. The kappa value for PET versus endoscopy was 0.62, which is categorized as substantial agreement. The kappa value for CT versus endoscopy was 0.40, which is categorized as fair agreement.
  
  
  CONCLUSIONS
  FDG-PET may be as efficacious as endoscopy with biopsy under general anesthesia for estimating tumor volume reduction with induction chemotherapy.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan 48109-0312, USA. dchepeha@umich.edu
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Chepeha
authors.forename: Assuntina G
authors.initials: AG
authors.lastname: Sacco
authors.forename: Lance E
authors.initials: LE
authors.lastname: Oxford
authors.forename: Rahul
authors.initials: R
authors.lastname: Karamchandani
authors.forename: Tamara H
authors.initials: TH
authors.lastname: Miller
authors.forename: Theodoros N
authors.initials: TN
authors.lastname: Teknos
authors.forename: Carol R
authors.initials: CR
authors.lastname: Bradford
authors.forename: Avraham
authors.initials: A
authors.lastname: Eisbruch
authors.forename: Frank M
authors.initials: FM
authors.lastname: Worden
authors.forename: Susan G
authors.initials: SG
authors.lastname: Urba
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Mukherji
authors.forename: Chuong
authors.initials: C
authors.lastname: Bui
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Frey
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Wolf
authors.forename: Julia S
authors.initials: JS
authors.lastname: Lee
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000188:drug therapy; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007828:Laryngoscopy; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18