Ventricular wall granulations and draining of cerebrospinal fluid in chronic giant hydrocephalus.
BACKGROUND
In rare cases, adults with normal or almost normal cognition may have giant brain ventricles surrounded by a sliver of brain. Because the usual flow of cerebrospinal fluid (CSF) is interrupted in these individuals, they may develop alternative CSF pathways to preserve brain function.


OBJECTIVE
To describe novel morphologic autopsy findings in a patient with chronic giant hydrocephalus that suggest the existence of alternative CSF draining pathways.


METHODS
Case report.


METHODS
Autopsy study.


METHODS
A 48-year-old man with chronic compensated hydrocephalus associated with a Dandy-Walker malformation.


METHODS
Autopsy findings.


RESULTS
We observed microscopic structures on the ventricular wall that may facilitate CSF resorption. Their histologic appearance, reminiscent of pacchionian granulations, showed the opposite relation in regard to CSF/blood compartments: whereas the core of a pacchionian granulation contains CSF and the granulation is bathed in blood of the venous sinus, the core of the ventricular granulation in our patient contained venules, with the granulation bathed in ventricular CSF.


CONCLUSIONS
These previously unreported (to our knowledge) ventricular wall granulations may facilitate draining of CSF into the venous system when CSF outflow from the ventricular system is occluded. The presence of these ventricular structures illustrates biologic adaptation to anomalous conditions and successful compensation.
Masdeu
Joseph C
JC
Department of Neurology and Neurosurgery, Clínica Universitaria de Navarra, Pamplona, Spain. masdeu@nih.gov
Pascual
Belen
B
Bressi
Federica
F
Casale
Manuele
M
Prieto
Elena
E
Arbizu
Javier
J
Fernández-Seara
Maria A
MA
D000222:Adaptation, Physiological / Q000502:physiology; D000328:Adult; D002552:Cerebral Ventricles / Q000473:pathology* / Q000503:physiopathology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D002908:Chronic Disease; D003616:Dandy-Walker Syndrome / Q000150:complications*; D004805:Ependyma / Q000166:cytology / Q000502:physiology; D004866:Equipment Contamination; D017809:Fatal Outcome; D005260:Female; D006097:Granulation Tissue / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D016920:Meningitis, Bacterial; D008875:Middle Aged; D014699:Venules / Q000166:cytology / Q000502:physiology