title: Catechols as membrane anion transporters.
abstract: We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that are easier to dehydrate are made more permeable to the membrane by 3.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
authors.forename: Sofya Kostina
authors.initials: SK
authors.lastname: Berezin
authors.forename: Jeffery T
authors.initials: JT
authors.lastname: Davis
mesh_terms: D000838:Anions / Q000737:chemistry; D002396:Catechols / Q000737:chemistry* / Q000378:metabolism*; D002463:Cell Membrane Permeability; D018118:Chloride Channels / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D027361:Organic Anion Transporters / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D000838:Anions; D002396:Catechols; D018118:Chloride Channels; D008051:Lipid Bilayers; D008081:Liposomes; D027361:Organic Anion Transporters