title: Prognostic value of miR-16 expression in childhood acute lymphoblastic leukemia relationships to normal and malignant lymphocyte proliferation.
abstract: miR-16, a miRNA involved in cell proliferation and apoptosis regulation, may interfere with either oncogenic or tumor-suppressor pathways and is implicated in leukemogenesis. We then explored its expression in 93 childhood acute lymphoblastic leukemia (ALL) cases. A high miR-16 expression was associated with hyperleukocytosis and poor cytogenetic groups. In the whole group and in B-cell ALLs, disease-free survival (DFS) was significantly shorter for miR-16 above quartile 75. In T-cell ALLs, for both DFS and overall survival, a significant trend was found with a survival shortening from the lowest to the highest miR-16 levels. miR-16 expression neither significantly correlated with normal and malignant lymphocyte proliferation nor varied according to lymphocyte differentiation. The prognostic value of miR-16 in childhood ALL highlighted the complexity of miR-16 functions.
authors.affiliation: LBMC, CNRS UMR5239, IFR128, Faculté de Médecine Lyon Sud, Université Lyon 1, 69495 Pierre Bénite, France.
authors.forename: T
authors.initials: T
authors.lastname: Kaddar
authors.forename: W W
authors.initials: WW
authors.lastname: Chien
authors.forename: Y
authors.initials: Y
authors.lastname: Bertrand
authors.forename: M P
authors.initials: MP
authors.lastname: Pages
authors.forename: J P
authors.initials: JP
authors.lastname: Rouault
authors.forename: G
authors.initials: G
authors.lastname: Salles
authors.forename: M
authors.initials: M
authors.lastname: Ffrench
authors.forename: J P
authors.initials: JP
authors.lastname: Magaud
mesh_terms: D000293:Adolescent; D015152:Blotting, Northern; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology; D011379:Prognosis
chemical_list: D035683:MicroRNAs