title: HTLV-2B Tax oncoprotein is modified by ubiquitination and sumoylation and displays intracellular localization similar to its homologue HTLV-1 Tax.
abstract: HTLV-1 is more pathogenic than HTLV-2B. The difference is generally attributed to the properties of their individual transactivating Tax proteins. By using internal Flag-6His tagged Tax-1 and Tax-2B, which display transcriptional activities comparable to the untagged proteins and can be recognized by a single anti-Flag antibody, we demonstrate that Tax-2B is modified by ubiquitination and sumoylation. In addition, Tax2B is distributed in punctuate nuclear structures that include the RelA subunit of NF-kappaB, as has been previously demonstrated for Tax-1.
authors.affiliation: Department of Mother and Child, Biology and Genetics, Section of Biology and Genetics, University of Verona, Strada Le Grazie 8, I-37134 Verona, Italy.
authors.forename: Marco
authors.initials: M
authors.lastname: Turci
authors.forename: Julie
authors.initials: J
authors.lastname: Lodewick
authors.forename: Paola
authors.initials: P
authors.lastname: Righi
authors.forename: Angela
authors.initials: A
authors.lastname: Polania
authors.forename: Maria Grazia
authors.initials: MG
authors.lastname: Romanelli
authors.forename: Françoise
authors.initials: F
authors.lastname: Bex
authors.forename: Umberto
authors.initials: U
authors.lastname: Bertazzoni
mesh_terms: D002460:Cell Line; D002467:Cell Nucleus / Q000737:chemistry; D016356:Gene Products, tax / Q000378:metabolism*; D015367:Human T-lymphotropic virus 2 / Q000502:physiology*; D006801:Humans; D051996:Transcription Factor RelA / Q000378:metabolism; D054875:Ubiquitination
chemical_list: D016356:Gene Products, tax; C498143:RELA protein, human; D051996:Transcription Factor RelA; C514971:tax protein, Human T-lymphotrophic virus 2