title: [Pulmonary involvement in the course of cytomegalovirus infection in an immunocompetent adult].
abstract: BACKGROUND
  Cytomegalovirus (CMV) infection in the immunocompetent is generally silent or it may present as a mononucleosis like syndrome but, rarely, it can lead to symptomatic manifestations.
  
  
  METHODS
  An immunocompetent and previously healthy 43- year-old woman presented with fever, dyspnoea, liver cell necrosis and a mononucleosis syndrome. The CT scan showed diffuse ground-glass opacity. BAL and blood cultures were sterile. Urinary antigens (Legionella pneumophila, Streptococcus pneumoniae) and serology for atypical respiratory pathogens (Mycoplasma pneumoniae and Chlamydia sp.) were negative. A diagnosis of CMV pneumonia was established on serology (presence of anti-CMV IgM) and PCR detection of viral DNA in the serum. Without antiviral therapy, there was a favourable clinical outcome 1 week later and 1 month later the CT scan was normal.
  
  
  CONCLUSIONS
  CMV infection can lead, exceptionally. to a hypoxic pneumonia in the immunocompetent host. Antiviral therapy should not be prescribed systematically.
authors.affiliation: Service de Pneumologie, HIA Legouest, Metz, France. j.magery@free.fr
authors.forename: J
authors.initials: J
authors.lastname: Margery
authors.forename: N
authors.initials: N
authors.lastname: Lefebvre
authors.forename: J-M
authors.initials: JM
authors.lastname: Dot
authors.forename: A
authors.initials: A
authors.lastname: Gervaise
authors.forename: D
authors.initials: D
authors.lastname: Andriamanantena
authors.forename: M
authors.initials: M
authors.lastname: Dieudonné
authors.forename: A
authors.initials: A
authors.lastname: Girodeau
mesh_terms: D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007121:Immunocompetence; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D011024:Pneumonia, Viral / Q000000981:diagnostic imaging / Q000209:etiology*; D016133:Polymerase Chain Reaction; D013902:Radiography, Thoracic; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M