[Effect of intra and postoperative magnesium sulphate infusion on postoperative pain].
OBJECTIVE
Evaluate the effect of intra and postoperative magnesium sulphate infusion on postoperative pain in abdominal surgery.


METHODS
Prospective double-blind randomized controlled study. Forty eight patients were randomly allocated to receive in the induction of anaesthesia, intraoperatively and six hours postoperatively either magnesium sulphate M Group (bolus 50 mg/kg and 0.5 g/h) or placebo (P Group). Patients were given a dose of morphine (0.1 mg/kg) IV, 45 min before the end of surgery. Sedation, pain scores, cumulative morphine consumption and adverse effects were recorded up to 24 hours postoperatively.


RESULTS
The duration of anaesthesia was similar in both groups. The time of the first demand of morphine was significantly longer in M Group then in P Group, respectively (18+/-5 min vs 7+/-1 min, p=0.03). Morphine consumption was significantly higher in control group than M group on the first postoperative day (52+/-4 mg vs 30+/-3 mg, p=0.0002). Pain scores were significantly lower in M group than in P group. Serum magnesium concentration was significantly higher in the M group. The frequency of side effects was similar in the two groups.


CONCLUSIONS
The results of the study support magnesium sulphate as useful adjuvant for postoperative analgesia in abdominal surgery.
Benhaj Amor
Mondher
M
Service d'Anesthśie Réanimation, Hôpital Militaire de Tunis.
Barakette
Mohamed
M
Dhahri
Sami
S
Ouezini
Rami
R
Lamine
Khaled
K
Jebali
Adel
A
Ferjani
Mustapha
M
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000700:Analgesics / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000008:administration & dosage; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D011182:Postoperative Care; D011446:Prospective Studies; D016896:Treatment Outcome
D000700:Analgesics; D000701:Analgesics, Opioid; D008278:Magnesium Sulfate; D009020:Morphine