title: Premature coronary artery disease: role of free radical nitric oxide.
abstract: OBJECTIVE
  Over the last several decades, it has become amply evident that oxidative stress plays a significant role in the pathogenesis of coronary artery atherosclerosis and its complications. Relatively recent studies have demonstrated an association between increased oxidative stress and coronary artery disease. We therefore undertook this study to see the effect of free radical nitric oxide in patients with premature cardiovascular disease.
  
  
  RESULTS
  The study included 50 individuals with premature coronary artery disease aged below 45 years, and 50 age- and sex-matched normal individuals for comparison. Free radical nitric oxide was estimated using the Griess reagent as previously described. Mean plasma nitric oxide was found to be high in the patient group as compared to the control group, which was found to be statistically significant at p > 0.0001.
  
  
  CONCLUSIONS
  Increased NO production was present in the plasma of patients with premature coronary artery disease individuals as compared to normal controls. Since NO seems to have a role in tissue damage, high concentrations of NO could have probably given rise to the said clinical manifestations. Further studies are needed in this context as to whether the changed lifestyles in the young individuals or the type of occupation is leading to the oxidative stress and thereby to the disease.
authors.affiliation: Department of Clinical Genetics, Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Hyderabad, India.
authors.forename: V V
authors.initials: VV
authors.lastname: Ravi Kanth
authors.forename: G J
authors.initials: GJ
authors.lastname: Prakash
authors.forename: Sudhir
authors.initials: S
authors.lastname: Naik
authors.forename: Nitin
authors.initials: N
authors.lastname: Kabra
authors.forename: M
authors.initials: M
authors.lastname: Sujatha
mesh_terms: D000328:Adult; D017668:Age of Onset; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D012307:Risk Factors
chemical_list: D009569:Nitric Oxide