Autophagy in the filamentous fungus Aspergillus fumigatus.
Many breakthroughs in our understanding of the function and molecular basis of autophagy have been achieved in mammalian and yeast systems. However, we still know very little about the contribution of autophagy to the biology of filamentous fungi. A comparative analysis of autophagy between genera will expand our knowledge of the autophagy machinery and has the potential to identify novel functions that are relevant to multiple biological systems. This chapter will discuss methods that have been employed for studying autophagy in the opportunistic mold pathogen Aspergillus fumigatus. Understanding how autophagy influences the growth of this important human pathogen could lead to the development of novel antifungal drugs that restrict the growth of the fungus by manipulating the autophagy pathway.
Richie
Daryl L
DL
Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, USA.
Askew
David S
DS
D001232:Aspergillus fumigatus / Q000166:cytology / Q000502:physiology*; D001343:Autophagy / Q000502:physiology*; D001681:Biological Assay / Q000379:methods*; D018929:Cell Culture Techniques; D003470:Culture Media / Q000737:chemistry; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans
D003470:Culture Media; D005656:Fungal Proteins