title: Noninvasive diagnosis of liver fibrosis in patients with HIV infection and HCV/HBV co-infection.
abstract: The measurement of fibrosis stage critically affects the identification of the progression of liver disease, the establishment of a prognosis and therapeutic decision making. Liver biopsy has been the single, most useful method to determine the degree of liver fibrosis (LF), but with recognized limitations, mainly associated with its invasiveness. In recent years, alternative noninvasive methods have been developed, including imaging methods, such as transient elastometry, and assays based on serum biomarkers. This article reviews the available studies evaluating the value of various noninvasive methods for the assessment of LF in patients with HIV-infection and HBV/HCV co-infection, and makes recommendations on how to best use and combine them in clinical practice.
authors.affiliation: Department of Infectious Diseases, Hospital Ramón y Cajal, Universidad de Alcalá, Madrid, Spain. smoreno.hrc@salud.madrid.org
authors.forename: S
authors.initials: S
authors.lastname: Moreno
authors.forename: J
authors.initials: J
authors.lastname: García-Samaniego
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: E
authors.initials: E
authors.lastname: Ortega
authors.forename: J A
authors.initials: JA
authors.lastname: Pineda
authors.forename: J
authors.initials: J
authors.lastname: del Romero
authors.forename: C
authors.initials: C
authors.lastname: Tural
authors.forename: M A
authors.initials: MA
authors.lastname: von Wichmann
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
authors.forename: A
authors.initials: A
authors.lastname: Castro
authors.forename: R
authors.initials: R
authors.lastname: Espacio
mesh_terms: D015415:Biomarkers / Q000097:blood; D054459:Elasticity Imaging Techniques / Q000379:methods; D015658:HIV Infections / Q000150:complications*; D006509:Hepatitis B / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis*; D011379:Prognosis; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers