Toxicological assessment of beta-lapachone on organs from pregnant and non-pregnant rats.
Naphthoquinones have been studied extensively due to their activity as topoisomerase inhibitors. These enzymes are critical to DNA replication in cells. beta-Lapachone (beta-lap) is an o-naphthoquinone chemically obtained from lapachol. This work results in a toxicological evaluation of beta-lap in Wistar rats observing the following parameters: teratology, histology, hematology and serum biochemistry. The data demonstrate teratogenic action at the doses used, as well as hematological alterations in the total leukocytes, monocytes and segmented. The biochemical data demonstrated an increase in gamma glutamyl transferase, alkaline phosphatase and glutamate pyruvate transaminase levels. Histological study showed significant alterations in the spleen, however, the liver and kidney did not present significant alterations.
de Almeida
Edvaldo Rodrigues
ER
Laboratory of Evaluation of Psychobioactive Drugs and its Toxicology, Federal University of Pernambuco, 50670-901 Recife PE, Brazil. Edvaldo.ra@gmail.com
Lucena
Flávia Raquel Santos
FR
Silva
Camilla Vila Nova Soares
CV
da Silva Costa-Junior
Wilson
W
Cavalcanti
Jouse Bezerra
JB
Couto
Gerald Bosco Lindoso
GB
da Silva
Luiz Lúcio Soares
LL
da Mota
Diógenes Luís
DL
da Silveira
Alex Benício
AB
de Sousa Filho
Samuel Daniel
SD
da Silva
Aldo Cezar Passilongo
AC
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D005260:Female; D007962:Leukocytes / Q000473:pathology; D008297:Male; D009285:Naphthoquinones / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000473:pathology; D013723:Teratogens / Q000633:toxicity*; D036401:Toxicity Tests, Chronic; D000637:Transaminases / Q000097:blood; D005723:gamma-Glutamyltransferase / Q000097:blood
D009285:Naphthoquinones; D013723:Teratogens; C014638:beta-lapachone; D005723:gamma-Glutamyltransferase; D000637:Transaminases; D000469:Alkaline Phosphatase