Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells.
Cinnamon is one of the most widely used herbal medicines with diverse bioactive effects. However, little evidence has been reported about the potential anti-tumor effects of cinnamon. In vitro and in vivo system, cinnamon treatment strongly inhibited the expression of pro-angiogenic factors and master regulators of tumor progression not only in melanoma cell lines but also in experimental melanoma model. In addition, cinnamon treatment increased the anti-tumor activities of CD8(+) T cells by increasing the levels of cytolytic molecules and their cytotoxic activity. In conclusion, cinnamon extract has the potential to be an alternative medicine for tumor treatment.
Kwon
Ho-Keun
HK
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
Jeon
Won Kyung
WK
Department of Herbal Resources Research and Quality Control Team, Korea Institute of Oriental Medicine, 305-811 Daejeon, Republic of Korea.
Hwang
Ji-Sun
JS
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
Lee
Choong-Gu
CG
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
So
Jae-Seon
JS
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
Park
Jin-A
JA
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea.
Ko
Byoung Seob
BS
Department of Herbal Resources Research and Quality Control Team, Korea Institute of Oriental Medicine, 305-811 Daejeon, Republic of Korea.
Im
Sin-Hyeog
SH
Department of Life Sciences, Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea; Center for Distributed Sensor Network Gwangju Institute of Science and Technology (GIST), 1 Oryong-dong, Puk-ku, Gwangju 500-712, Republic of Korea. Electronic address: imsh@gist.ac.kr.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D045744:Cell Line, Tumor; D002935:Cinnamomum zeylanicum; D052246:Cyclooxygenase 2 Inhibitors / Q000494:pharmacology; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000037:antagonists & inhibitors; D036341:Intercellular Signaling Peptides and Proteins / Q000032:analysis / Q000235:genetics; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010936:Plant Extracts / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D052246:Cyclooxygenase 2 Inhibitors; C497443:Hif1a protein, mouse; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D036341:Intercellular Signaling Peptides and Proteins; D010936:Plant Extracts