Synthesis and cytotoxicity screening of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones.
A new series of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones were synthesized via a five-steps procedure starting from 2-amino-5-methylbenzoic acid. The cytotoxicity of the resulting compounds against A-549 (human lung cancer), HCT-8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported.
Cao
Sheng-Li
SL
Department of Chemistry, Capital Normal University, Beijing, China. sl_cao@sohu.com
Guo
Yan-Wen
YW
Wang
Xian-Bo
XB
Zhang
Mei
M
Feng
Yu-Ping
YP
Jiang
Yu-Yang
YY
Wang
Yue
Y
Gao
Qian
Q
Ren
Jian
J
D000970:Antineoplastic Agents / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D052999:Quinazolinones