Studying the interactions of drugs and hydrophobic model membranes using contact angle goniometry.
This study demonstrates a method where contact angle goniometry combined with surface tension measurements is used to assess the interactions of drugs with the hydrophobic core of a biological membrane. To this end, self-assembled monolayers (SAMs) of two alkanethiol and one thiolipid on Au(111) surfaces are used as model membranes and their interaction with six beta-blockers is studied. The Gibbs equation and the Langmuir adsorption isotherm are used to determine the partition coefficients for the adsorption of the drugs, which are compared to the octanol-water partition coefficients as well as the liposome-water partition coefficients. The ability of the different SAMs to serve as model membranes in partitioning of drugs is discussed.
Ikonen
Marjukka
M
Helsinki University of Technology, Laboratory of Physical Chemistry and Electrochemistry, PO Box 6100, FI-02015 TKK, Finland.
Murtomäki
Lasse
L
Kontturi
Kyösti
K
D001672:Biocompatible Materials / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D008567:Membranes, Artificial; D013499:Surface Properties
D001672:Biocompatible Materials; D008567:Membranes, Artificial