Reprogrammed induced pluripotent stem cells: how suitable could they be in reproductive medicine?
Human embryonic stem cells have the greatest potential for regenerative and reproductive medicine; unfortunately, their full application is limited by ethical and technical problems. In order to overcome these problems and get patient specific pluripotent cells from somatic cells, the field of reprogramming has moved to the generation of induced pluripotent stem cells by overexpression of four transcription factors after viral infection of the patient's somatic cells. In the present paper we review the limitations and milestones of this technique in both regenerative and reproductive medicine.
Ensenat-Waser
Roberto
R
Spanish Stem Cell Bank, Prince Felipe Research Centre (CIFP), Valencia, Spain.
Pellicer
Antonio
A
Simon
Carlos
C
D065150:Cellular Reprogramming / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000378:metabolism / Q000502:physiology*; D044968:Regenerative Medicine / Q000379:methods; D018456:Reproductive Medicine / Q000379:methods*