title: Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.
abstract: Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.
authors.affiliation: Department of Chemistry, University of Buea, PO Box 63, Buea, Southwest Province, Cameroon. smnefange@yahoo.com
authors.forename: Simon M N
authors.initials: SM
authors.lastname: Efange
authors.forename: Reto
authors.initials: R
authors.lastname: Brun
authors.forename: Sergio
authors.initials: S
authors.lastname: Wittlin
authors.forename: Joseph D
authors.initials: JD
authors.lastname: Connolly
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Hoye
authors.forename: Thomas
authors.initials: T
authors.lastname: McAkam
authors.forename: Felix L
authors.initials: FL
authors.lastname: Makolo
authors.forename: James A
authors.initials: JA
authors.lastname: Mbah
authors.forename: Dorian P
authors.initials: DP
authors.lastname: Nelson
authors.forename: Kennedy D
authors.initials: KD
authors.lastname: Nyongbela
authors.forename: Clare K
authors.initials: CK
authors.lastname: Wirmum
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D029785:Cyperaceae / Q000737:chemistry*; D004351:Drug Resistance / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D012717:Sesquiterpenes; C550401:okundoperoxide; D002738:Chloroquine