title: An adaptive mean-shift framework for MRI brain segmentation.
abstract: An automated scheme for magnetic resonance imaging (MRI) brain segmentation is proposed. An adaptive mean-shift methodology is utilized in order to classify brain voxels into one of three main tissue types: gray matter, white matter, and Cerebro-spinal fluid. The MRI image space is represented by a high-dimensional feature space that includes multimodal intensity features as well as spatial features. An adaptive mean-shift algorithm clusters the joint spatial-intensity feature space, thus extracting a representative set of high-density points within the feature space, otherwise known as modes. Tissue segmentation is obtained by a follow-up phase of intensity-based mode clustering into the three tissue categories. By its nonparametric nature, adaptive mean-shift can deal successfully with nonconvex clusters and produce convergence modes that are better candidates for intensity based classification than the initial voxels. The proposed method is validated on 3-D single and multimodal datasets, for both simulated and real MRI data. It is shown to perform well in comparison to other state-of-the-art methods without the use of a preregistered statistical brain atlas.
authors.affiliation: Medical Image Processing Laboratory, Tel-Aviv University, Tel-Aviv, Israel. arnmayer@gmail.com
authors.forename: Arnaldo
authors.initials: A
authors.lastname: Mayer
authors.forename: Hayit
authors.initials: H
authors.lastname: Greenspan
mesh_terms: D000465:Algorithms; D001921:Brain / Q000033:anatomy & histology*; D016000:Cluster Analysis; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008390:Markov Chains; D016011:Normal Distribution; D015203:Reproducibility of Results