Implementation of quantitative perfusion imaging using pulsed arterial spin labeling at ultra-high field.
This study compares the implementation of the STAR and FAIR pulsed arterial spin labeling (PASL) schemes to form quantitative perfusion maps at ultra-high field, 7 Tesla (T), and high field, 3 T. Phantom experiments were performed to compare the inversion efficiency and profile of the labeling pulses at 7 T and 3 T and to optimize in-plane saturation techniques. The perfusion weighted (PW) signal was measured at a range of postlabeling delay times and quantitative perfusion maps were calculated on a voxel-by-voxel basis. An increase in PW signal was found with field strength, and together with the increased signal-to-noise ratio, this led to improved image signal-to-noise and quality of fit of perfusion maps at 7 T.
Gardener
A G
AG
Sir Peter Mansfield Magnetic Resonance Centre, School of Physics and Astronomy, University of Nottingham, United Kingdom.
Gowland
P A
PA
Francis
S T
ST
D001158:Arteries / Q000033:anatomy & histology* / Q000502:physiology*; D001783:Blood Flow Velocity / Q000502:physiology*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods*; D012680:Sensitivity and Specificity; D013113:Spin Labels; D055815:Young Adult
D013113:Spin Labels