Hedgehog signaling: is Smo a G protein-coupled receptor?
The Hedgehog signal transducer Smoothened is structurally similar to G protein-coupled receptors. Now there is direct evidence that Smoothened relies on heterotrimeric G proteins in order to transduce the Hedgehog signal.
Philipp
Melanie
M
Departments of Cell Biology, Medicine, and Neurobiology, Duke University Medical Center, Durham, NC 27710, USA.
Caron
Marc G
MG
D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D053823:Hedgehog Proteins / Q000378:metabolism; D008954:Models, Biological; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D000072086:Smoothened Receptor
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D043562:Receptors, G-Protein-Coupled; C100664:smo protein, Drosophila; D000072086:Smoothened Receptor