title: Fabrication of terazocin-loaded poly(D,L-lactide) microspheres by an ultrasonic spray drying method and their release behaviors.
abstract: Terazocin should be frequently administered for a long period time for the treatment of benign prostatic hyperplasia which is one of the most common diseases in elderly men. Controlled delivery of terazocin using polymer microspheres has a great potential to solve the problem. In this study, terazocin-incorporated poly(D,L-lactide) (PDLLA) microspheres were fabricated by a novel ultrasonic spray drying (USD) method, which is a rapid one-step process. The approximate diameters of microspheres were in a range of between 0.3 and 3 microm. SEM confirmed that the microspheres had a spherical shape and narrow size distribution. FT-IR spectroscopy demonstrated that the incorporated terazocin remained intact after the USD process. The microspheres showed a fast initial burst release of terazocin within nine hours, followed by a slow but steady release for 49 days, suggesting that these microspheres are highly promising for controlled drug delivery.
authors.affiliation: Department of Fine Chemical Engineering, Hanyang University, 426-791 Gyeonggi-do, Korea.
authors.forename: Guk-Hwan
authors.initials: GH
authors.lastname: An
authors.forename: Min-Jung
authors.initials: MJ
authors.lastname: Kim
authors.forename: Hak-Jong
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Park
authors.forename: Yong Woo
authors.initials: YW
authors.lastname: Cho
authors.forename: Kinam
authors.initials: K
authors.lastname: Park
authors.forename: Yong-Ho
authors.initials: YH
authors.lastname: Choa
mesh_terms: D008855:Microscopy, Electron, Scanning; D011091:Polyesters / Q000737:chemistry*; D011224:Prazosin / Q000031:analogs & derivatives* / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014465:Ultrasonics
chemical_list: D011091:Polyesters; C033616:poly(lactide); C041226:Terazosin; D011224:Prazosin