title: A molecularly imprinted polymer-coated nanocomposite of magnetic nanoparticles for estrone recognition.
abstract: In this study, we synthesized Fe(3)O(4) magnetic nanoparticles coated estrone-imprinted polymer with controlled size using a semi-covalent imprinting strategy. In this protocol, the estrone-silica monomer complex (EstSi) was synthesized by the reaction 3-(triethoxysilyl)propyl isocyanate with estrone, where the template was linked to the silica coating on the iron oxide core via a thermally reversible bond. The removal of the template by a simple thermal reaction produced specific estrone recognition sites on the surface of silica shell.The resulting estrone-imprinted polymer coating Fe(3)O(4) magnetic hybrid nanoparticles exhibit a much higher specific recognition and saturation magnetization. The hybrid nanoparticles have been used for biochemical separation of estrone.
authors.affiliation: Department of Chemistry, Nankai University, Tianjin 300071, PR China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Lianyan
authors.initials: L
authors.lastname: Wang
authors.forename: Xiwen
authors.initials: X
authors.lastname: He
authors.forename: Yukui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Langxing
authors.initials: L
authors.lastname: Chen
mesh_terms: D020099:Coated Materials, Biocompatible; D004970:Estrone / Q000032:analysis / Q000302:isolation & purification*; D005290:Ferric Compounds; D008280:Magnetics; D008722:Methods; D054802:Molecular Imprinting; D053761:Nanocomposites / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D012822:Silicon Dioxide
chemical_list: D020099:Coated Materials, Biocompatible; D005290:Ferric Compounds; C000499:ferric oxide; D004970:Estrone; D012822:Silicon Dioxide