title: Synthesis and cytotoxicity screening of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones.
abstract: A new series of piperazine-1-carbodithioate derivatives of 2-substituted quinazolin-4(3H)-ones were synthesized via a five-steps procedure starting from 2-amino-5-methylbenzoic acid. The cytotoxicity of the resulting compounds against A-549 (human lung cancer), HCT-8 (human colon cancer), HepG2 (human liver cancer), and K562 (human myelogenous leukaemia) cell lines was determined by the MTT assay. Preliminary screening results of these compounds are reported.
authors.affiliation: Department of Chemistry, Capital Normal University, Beijing, China. sl_cao@sohu.com
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Cao
authors.forename: Yan-Wen
authors.initials: YW
authors.lastname: Guo
authors.forename: Xian-Bo
authors.initials: XB
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Zhang
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Feng
authors.forename: Yu-Yang
authors.initials: YY
authors.lastname: Jiang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Qian
authors.initials: Q
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Ren
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D052999:Quinazolinones