A novel molecular interaction for the adhesion of follicular CD4 T cells to follicular DC.
Nectins and Nectin-like molecules (Necl) play a critical role in cell polarity within epithelia and in the nervous and reproductive systems. Recently, immune receptors specific for Nectins/Necl have been described. Since the expression and distribution of Nectins/Necl is often subverted during tumorigenesis, it has been suggested that the immune system may use these receptors to recognize and eliminate tumors. Here we describe a novel immunoreceptor, Washington University Cell Adhesion Molecule, which is expressed on human follicular B helper T cells (TFH) and binds a Nectin/Necl family member, the poliovirus receptor (PVR), under both static and flow conditions. Furthermore, we demonstrate that PVR is abundantly expressed by follicular DC (FDC) within the germinal center. These results reveal a novel molecular interaction that mediates adhesion of TFH to FDC and provide the first evidence that immune receptors for Nectins/Necl may be involved the generation of T cell-dependent antibody responses.
Boles
Kent S
KS
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA.
Vermi
William
W
Facchetti
Fabio
F
Fuchs
Anja
A
Wilson
Timothy J
TJ
Diacovo
Thomas G
TG
Cella
Marina
M
Colonna
Marco
M
D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D002448:Cell Adhesion / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D016764:Cell Polarity / Q000276:immunology; D020566:Dendritic Cells, Follicular / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018858:Germinal Center / Q000276:immunology / Q000378:metabolism; D006801:Humans; D000075983:Nectins; D014066:Palatine Tonsil / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D011991:Receptors, Virus / Q000276:immunology* / Q000378:metabolism
D015815:Cell Adhesion Molecules; D000075983:Nectins; D011971:Receptors, Immunologic; D011991:Receptors, Virus; C539748:WUCAM protein, human; C066100:poliovirus receptor