Laryngeal histoplasmosis in an immunocompetent patient from a non-endemic region: case report.
Histoplasma capsulatum infection involving the larynx is a rare manifestation, especially in immunocompetent individuals and a high index of suspicion is needed to establish the diagnosis correctly. We report a case of a 50-year-old Brazilian man who presented with progressive hoarseness and throat pain for 4 months. Laryngoscopy showed a supraglottic vegetant lesion, and the biopsies chronic granulomatous inflammation without any specific agent. A second laryngoscopy with biopsies was performed and after 17 days of incubation in specific medium, H. capsulatum was isolated. The patient was successfully treated with amphotericin B.
Ferrari
Teresa C A
TC
Soares
João Marcos A
JM
Salles
José Maria P
JM
Handam
Júnia S
JS
Azevedo
Rosana C S
RC
Xavier
Marcelo A P
MA
Faria
Luciana C
LC
D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D001938:Brazil; D006651:Histocytochemistry; D006658:Histoplasma / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D007818:Laryngeal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D007828:Laryngoscopy; D007830:Larynx / Q000473:pathology; D008297:Male; D008875:Middle Aged
D000935:Antifungal Agents; D000666:Amphotericin B