Lipid peroxidation and antioxidant status in hypertensive pregnancies.
OBJECTIVE
The present study was designed to evaluate the lipid peroxidation and non-enzymatic antioxidant status in hypertensive complications during pregnancy (preeclamptic and eclamptic) compared with healthy pregnant and non-pregnant patients as controls.


METHODS
25 healthy non-pregnant women as controls, 25 third trimester normal pregnant women and 25 preeclamptic and 25 eclamptic patients of the same trimester. Lipid peroxidation as a thiobarbituric acid reactive substance reduced glutathione, Vitamin E, Vitamin C and Vitamin A.


RESULTS
Lipid peroxidation was significantly elevated and significantly decreased levels of antioxidants were found in preeclamptic and eclamptic patients as compared with normal pregnant and control subjects.


CONCLUSIONS
Our study gives support to those few studies considering lipid peroxidation as an important factor in the pathogenesis of preeclampsia and eclampsia. The decrease in antioxidants, probably of a compensatory nature responding to the increased peroxide load in preeclampsia and eclampsia, may reflect the severity of the disease.
Patil
S B
SB
Department of Biochemistry, J.N. Medical College Nehru, Karnataka, India. sanrum03@yahoo.co.in
Kodliwadmath
M V
MV
Kodliwadmath
S M
SM
D000328:Adult; D016022:Case-Control Studies; D004461:Eclampsia / Q000097:blood*; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood*; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D014815:Vitamins / Q000097:blood; D055815:Young Adult
D014815:Vitamins; D008315:Malondialdehyde; D005978:Glutathione