title: Fatal cases of Staphylococcus aureus pleural empyema in infants.
abstract: Community-associated infections and especially pleural empyema due to Staphylococcus aureus are increasing worldwide. The virulence of staphylococcal strains is notably determined by different toxin expressing-genes, such as the Panton-Valentine leukocidin (PVL) gene found in S. aureus isolates obtained from pediatric necrotizing pneumonia samples. We describe 2 similar cases of infants with severe respiratory distress and death after an upper respiratory tract infection, having occurred in the same urban area during the same winter time. Necropsies performed between November 2006 and March 2007 revealed bronchopneumonia and an important pleural empyema, justifying the review of clinical charts and laboratory exams. A methicillin-sensitive S. aureus (MSSA) isolate carrying the PVL gene was identified in both cases. We have subsequently cared for an additional case in the same time interval with sudden death and similar pathological findings. No positive microbiological results were obtained, a negative finding possibly related to a 5-day antibiotics regimen. This report describes the pathological features of these cases and stresses the need to recognize PVL-positive S. aureus infections in young children. Finally, we believe that all lethal infections due to PVL-positive S. aureus, independently of the methicillin resistance profile, deserve a mandatory report to the provincial public health authorities.
authors.affiliation: Department of Pathology, CHU Sainte-Justine, 3175 chemin de la Côte-Ste-Catherine, Montréal, Quebec, Canada.
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Rougemont
authors.forename: Chantal
authors.initials: C
authors.lastname: Buteau
authors.forename: Philippe
authors.initials: P
authors.lastname: Ovetchkine
authors.forename: Cybèle
authors.initials: C
authors.lastname: Bergeron
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Fournet
authors.forename: Dorothée
authors.initials: D
authors.lastname: Bouron-Dal Soglio
mesh_terms: D016724:Empyema, Pleural / Q000382:microbiology* / Q000473:pathology* / Q000503:physiopathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013203:Staphylococcal Infections / Q000382:microbiology* / Q000473:pathology* / Q000503:physiopathology; D013211:Staphylococcus aureus