Association of polymorphisms of NOD2, TLR4 and CD14 genes with susceptibility to gastric mucosa-associated lymphoid tissue lymphoma.
BACKGROUND
The clinical course of Helicobacter pylori infection is highly variable and is influenced by both microbial and host factors, including the genetic composition of the infecting strains and variations in the host immune responses. A genetic risk profile for gastric cancer has been identified, but genetic susceptibility to develop gastric mucosa-associated lymphoid tissue (MALT) lymphoma is unclear. The aim of this study was to evaluate the relationship between NOD2, TLR4 and CD14 genetic polymorphisms and the development of gastric MALT-lymphoma.


METHODS
Fifty-six patients with primary gastric MALT lymphoma and 51 patients with H. pylori infection were enrolled in this study. The polymorphisms were detected by the PCR-restriction fragment length polymorphism (RFLP) method of allele-specific PCR.


RESULTS
No polymorphisms in the NOD2 and TLR4 genes were found to be associated with the development of gastric MALT lymphoma. Carriers of the CD14 gene -159T allele had a marginally increased risk of developing gastric MALT lymphoma than the controls (p=0.042).


CONCLUSIONS
The -159C/T genetic polymorphism of the CD14 gene may be implicated in the development of gastric MALT lymphoma.
Türe-Ozdemir
Filiz
F
Institute of Gastroenterology, Marmara University, Istanbul, Turkey.
Gazouli
Maria
M
Tzivras
Michalis
M
Panagos
Charalambos
C
Bovaretos
Nikolaos
N
Petraki
Kalliopi
K
Giannakopoulos
Athanassios
A
Korkolopoulou
Penelope
P
Mantzaris
Gerassimos J
GJ
D000328:Adult; D000368:Aged; D005753:Gastric Mucosa / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000235:genetics*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics*; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D051197:Toll-Like Receptor 4 / Q000235:genetics*
D018950:Lipopolysaccharide Receptors; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein; C495345:TLR4 protein, human; D051197:Toll-Like Receptor 4