Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571.
Ammocidins B, C and D were isolated from the culture broth of Saccharothrix sp. AJ9571, an ammocidin A-producing strain. Their structures were determined by a detailed spectroscopic analysis and by a comparison of their NMR data with those of ammocidin A. Ammocidins A and B showed potent anti-proliferative activities against human cancer cell lines.
Murakami
Ryo
R
Exploratory Research Laboratories II, Daiichi-Sankyo Co., Ltd, Tokyo, Japan. murakami.ryo.bw@daiichisankyo.co.jp
Shinozaki
Junko
J
Kajiura
Takayuki
T
Kozone
Ikuko
I
Takagi
Motoki
M
Shin-Ya
Kazuo
K
Seto
Haruo
H
Hayakawa
Yoichi
Y
D000192:Actinomycetales / Q000737:chemistry* / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry*; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C544238:ammocidin B; C544239:ammocidin C; C544240:ammocidin D