The impact of the aortic pulse wave velocity on the cardiovascular outcomes of hemodialysis patients.
The aims of our study were to identify the risk factors for an increased aortic pulse wave velocity (AoPWV) and to assess the impact of the AoPWV on the cerebro-cardiovascular (CV) outcomes of hemodialysis (HD) patients. Seventy two HD patients were included, and the AoPWV, the echocardiography and the biochemical parameters were measured. After dividing the patients into tertiles according to the AoPWV values, we defined the low, the middle and the high AoPWV groups. The patients in the high AoPWV group showed a significantly higher age and high-sensitivity C-reactive protein level, a greater prevalence of diabetes and statin use, left ventricular hypertrophy, average pulse pressure (PP), AoPWV and left ventricular mass index and a lower serum albumin level than those in the low AoPWV group (p<0.05). On multivariate regression analysis of the AoPWV, age and the average PP were independently related to the AoPWV (p<0.05). On the multivariate Cox analysis for CV outcomes, the AoPWV and the average PP remained significant independent predictors of CV events. Our data suggest that an increased AoPWV is an independent predictor for the CV outcomes of HD patients.
Shin
Seok Joon
SJ
Division of Nephrology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim
Yong Kyun
YK
Chung
Sungjin
S
Chung
Hyun Wha
HW
Ihm
Sang Hyun
SH
Park
Cheol Whee
CW
Kim
Young Ok
YO
Song
Ho Cheol
HC
Kim
Yong Soo
YS
Choi
Eui-Jin
EJ
D000328:Adult; D000368:Aged; D000418:Albumins / Q000378:metabolism; D001011:Aorta / Q000473:pathology*; D002097:C-Reactive Protein / Q000378:metabolism; D004452:Echocardiography / Q000379:methods; D005260:Female; D006339:Heart Rate; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011674:Pulse; D006435:Renal Dialysis / Q000379:methods
D000418:Albumins; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D002097:C-Reactive Protein