Regulatory mechanism of Bcl-2 in uterine leiomyomas.
Bcl-2 has been thought to play a vital role in the growth of uterine leiomyomas. However, it remains to be fully understood how Bcl-2 expression is regulated in uterine leiomyomas. Several factors have been speculated to affect the induction of Bcl-2 in these cells, including progesterone, endoplasmic reticulum stress, and microRNAs. The elucidation of the regulatory mechanism of Bcl-2 will contribute to a better understanding of the molecular biology of uterine leiomyomas.
Ohara
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D004721:Endoplasmic Reticulum; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000378:metabolism*; D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D013312:Stress, Physiological; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000378:metabolism*
D035683:MicroRNAs; D019253:Proto-Oncogene Proteins c-bcl-2