title: Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571.
abstract: Ammocidins B, C and D were isolated from the culture broth of Saccharothrix sp. AJ9571, an ammocidin A-producing strain. Their structures were determined by a detailed spectroscopic analysis and by a comparison of their NMR data with those of ammocidin A. Ammocidins A and B showed potent anti-proliferative activities against human cancer cell lines.
authors.affiliation: Exploratory Research Laboratories II, Daiichi-Sankyo Co., Ltd, Tokyo, Japan. murakami.ryo.bw@daiichisankyo.co.jp
authors.forename: Ryo
authors.initials: R
authors.lastname: Murakami
authors.forename: Junko
authors.initials: J
authors.lastname: Shinozaki
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kajiura
authors.forename: Ikuko
authors.initials: I
authors.lastname: Kozone
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-Ya
authors.forename: Haruo
authors.initials: H
authors.lastname: Seto
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hayakawa
mesh_terms: D000192:Actinomycetales / Q000737:chemistry* / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry*; D002240:Carbohydrate Sequence; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D018942:Macrolides / Q000737:chemistry* / Q000378:metabolism; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000903:Antibiotics, Antineoplastic; D018942:Macrolides; C544238:ammocidin B; C544239:ammocidin C; C544240:ammocidin D