title: Effects of long-term administration of royal jelly on pituitary weight and gene expression in middle-aged female rats.
abstract: To determine the effects of ingested royal jelly (RJ) on the pituitary in middle-aged female rats, we performed a long-term RJ administration test. Several animals showed age-related increases in pituitary weight, and RJ administration compensated for the increase. RJ tended to down-regulate prolactin mRNA and up-regulated thyroid-stimulating hormone beta mRNA in the pituitary. This suggests that RJ compensates for age-associated decline in pituitary functions.
authors.affiliation: Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Narita
authors.forename: Shozo
authors.initials: S
authors.lastname: Ohta
authors.forename: Kazu-Michi
authors.initials: KM
authors.lastname: Suzuki
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nemoto
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.forename: Satoshi
authors.initials: S
authors.lastname: Mishima
mesh_terms: D000375:Aging / Q000187:drug effects / Q000235:genetics; D000818:Animals; D005227:Fatty Acids / Q000008:administration & dosage* / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000033:anatomy & histology* / Q000187:drug effects*; D010907:Pituitary Hormones / Q000235:genetics; D011388:Prolactin / Q000097:blood / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D000099219:Royal Jelly
chemical_list: D005227:Fatty Acids; D010907:Pituitary Hormones; D011388:Prolactin; D013974:Thyroxine; D000099219:Royal Jelly