Mesalazine-induced interstitial nephritis.
5-aminosalicylate compounds (mesalazine, sulfasalazine) are widely used in therapy of inflammatory bowel diseases. Mesalazine-induced interstitial nephritis is a rare complication; however, the morbidity in an affected individual is high. Regular renal screening in patients treated with 5-aminosalicylate compounds is important. A 15-year-old boy with treated idiopathic proctocolitis, consequent mesalazine-induced nephritis, and a favorable response to corticotherapy is presented.
Skalova
Sylva
S
Department of Pediatrics, Charles University in Prague, Faculty of Medicine and University Hospital in Hradec Králové, Czech Republic. skalova.s@seznam.cz
Dedek
Petr
P
Pozler
Oldrich
O
Podhola
Miroslav
M
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D006801:Humans; D008297:Male; D019804:Mesalamine / Q000009:adverse effects*; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D011350:Proctocolitis / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D019804:Mesalamine