Protein kinase C epsilon in cell division: control of abscission.
Cell division requires the separation and partitioning of sister chromatids to opposite ends of the cell before an actomyosin ring contracts the membrane in between during cytokinesis. The final irreversible step occurs during abscission when the ring breaks down and the membrane is sealed in its place. The physical mechanics of contraction depend on RhoA, which is stimulated by a centralspindlin complex around the cell equator. However exactly how these events are reversed to allow actomyosin breakdown and abscission were not well understood. Here we will discuss new findings that implicate Protein Kinase C epsilon (PKCepsilon) as a regulator of RhoA signalling required for abscission.
Saurin
Adrian T
AT
Protein Phosphorylation Laboratory, London Research Institute, Cancer Research UK, London, UK.
Brownlow
Nicola
N
Parker
Peter J
PJ
D048948:14-3-3 Proteins / Q000378:metabolism; D000818:Animals; D002455:Cell Division / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D051744:Protein Kinase C-epsilon / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D008941:Spindle Apparatus / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000235:genetics / Q000378:metabolism*
D048948:14-3-3 Proteins; D034741:RNA, Small Interfering; D011993:Recombinant Fusion Proteins; D051744:Protein Kinase C-epsilon; D020742:rhoA GTP-Binding Protein