title: Saldedines A and B, dibromo proaporphine alkaloids from a Madagascan tunicate.
abstract: Two new dibromo proaporphine alkaloids, designated saldedines A (1) and B (2), were isolated from an unidentified tunicate collected at Salary Bay, Madagascar. Saldedines A and B are the first marine proaporphine alkaloids. Their structures were elucidated by extensive spectroscopic means, and the structure of 1 was confirmed by single-crystal X-ray diffraction analysis. Both saldedines A and B were tested for toxicity to brine shrimp and showed moderate activity.
authors.affiliation: School of Chemistry, Tel-Aviv University, Ramat Aviv, Israel.
authors.forename: Hagit
authors.initials: H
authors.lastname: Sorek
authors.forename: Amira
authors.initials: A
authors.lastname: Rudi
authors.forename: Israel
authors.initials: I
authors.lastname: Goldberg
authors.forename: Maurice
authors.initials: M
authors.lastname: Aknin
authors.forename: Yoel
authors.initials: Y
authors.lastname: Kashman
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects*; D018360:Crystallography, X-Ray; D008386:Marine Biology; D015394:Molecular Structure; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001060:Aporphines; C540704:saldedine A; C540705:saldedine B