title: Kinetically controlled self-assembly of DNA oligomers.
abstract: Metastable two-stranded DNA loops can be assembled into extended DNA oligomers by kinetically controlled self-assembly. Along the designed reaction pathway, the sequence of hybridization reactions is controlled by progressively revealing toeholds required to initiate strand-displacement reactions. The product length depends inversely on seed concentration and ranges from a few hundred to several thousand base-pairs.
authors.affiliation: Department of Physics, University of Oxford, South Parks Road, Oxford, OX1 3PU, UK. phyld@nus.edu.sg
authors.forename: Daniel
authors.initials: D
authors.lastname: Lubrich
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Green
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Turberfield
mesh_terms: D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D004591:Electrophoresis, Polyacrylamide Gel; D007700:Kinetics; D009690:Nucleic Acid Conformation; D009693:Nucleic Acid Hybridization; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D009841:Oligonucleotides; D004247:DNA