title: Pulmonary alveolar proteinosis in a patient with Behcet's disease.
abstract: Secondary pulmonary alveolar proteinosis (PAP) has been described in several clinical settings that can be grouped into three main categories: infections of the lung; haematological malignancies and other conditions that alter the patient's immune status; and exposure to inhaled chemicals and minerals. Recent studies reported that anti-granulocyte-macrophage colony-stimulating factor (GM-CSF) antibody was present in the serum of patients with idiopathic PAP but not in patients with secondary PAP or in normal subjects. The present report describes the interesting case of a patient with Behcet's disease and PAP. The absence of anti-GM-CSF antibodies in this patient suggested a diagnosis of secondary PAP.
authors.affiliation: Department of Advanced Molecular Cell Therapy, Kyushu University, Fukuoka, Japan. mi.uchiyama@scchr.jp
authors.forename: Michihiro
authors.initials: M
authors.lastname: Uchiyama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nagao
authors.forename: Aritoshi
authors.initials: A
authors.lastname: Hattori
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Fujii
authors.forename: Toshio
authors.initials: T
authors.lastname: Ichiwata
authors.forename: Koh
authors.initials: K
authors.lastname: Nakata
authors.forename: Kenzaburo
authors.initials: K
authors.lastname: Tani
authors.forename: Takuya
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood / Q000276:immunology; D001528:Behcet Syndrome / Q000150:complications*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000276:immunology; D006801:Humans; D011649:Pulmonary Alveolar Proteinosis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*
chemical_list: D000906:Antibodies; D016178:Granulocyte-Macrophage Colony-Stimulating Factor