[Disease gene screening of known loci in a Chinese family with autosomal dominant retinitis pigmentosa].
OBJECTIVE
To map the disease-causing gene in a Chinese family with autosomal dominant retinitis pigmentosa.


METHODS
Twenty-seven micro-satellite markers were randomly selected from the region around the known loci of causative genes, and haplotypes were determined by ABI3100 genetic analyzer. Two-point linkage analysis was performed using MLINK.


RESULTS
The Lod score of each marker vs adRP was below 1.


CONCLUSIONS
The phenotype of this family may not be caused by mutation of the known disease-causing genes.
Liu
Wei
W
Department of Pathobiology, Chongqing Medical University, Chongqing, 400016 PR China.
Lu
Fang
F
Qia
Li-feng
LF
Sha
Zhi-quan
ZQ
Liu
Xia-oqi
XO
Ma
Shi
S
Tang
Xin
X
Chang
Jin-xia
JX
Yang
Zheng-lin
ZL
Ye
Bin
B
D044466:Asian People / Q000235:genetics*; D002681:China; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D005820:Genetic Testing; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D012174:Retinitis Pigmentosa / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology