Low-affinity peptides and T-cell selection.
The dual requirement for T cells to recognize a particular major histocompatibility complex (MHC) antigen presenting a foreign peptide and to lack strong reactivity with a complex of the same molecule when bound to a self-peptide, is attained by thymic positive and negative selection processes, the molecular details of which are currently only partially understood. However, the discovery of the thymoproteasome and our improved understanding of the dynamics of peptide presentation permit us to suggest that the biophysical properties of the MHC:peptide class I complexes engaged in positive T-cell selection will be distinct from those involved in negative selection, hence imposing differential barriers for T cells.
Ziegler
Andreas
A
Institut für Immungenetik, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Freie Universität Berlin, Thielallee 73, 14195 Berlin, Germany. andreas.ziegler@charite.de
Müller
Claudia A
CA
Böckmann
Rainer A
RA
Uchanska-Ziegler
Barbara
B
D017951:Antigen Presentation; D002470:Cell Survival; D008285:Major Histocompatibility Complex / Q000276:immunology*; D018448:Models, Immunological; D009928:Organ Specificity; D046988:Proteasome Endopeptidase Complex / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D055550:Protein Stability; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D037182:T-Cell Antigen Receptor Specificity; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D011948:Receptors, Antigen, T-Cell; C520308:PSMB11 protein, human; D046988:Proteasome Endopeptidase Complex