title: Electron capture dissociation and collision-induced dissociation of metal ion (Ag(+), Cu(2+), Zn(2+), Fe(2+), and Fe(3+)) complexes of polyamidoamine (PAMAM) dendrimers.
abstract: The electron capture dissociation (ECD) and collision-induced dissociation (CID) of complexes of polyamidoamine (PAMAM) dendrimers with metal ions Ag(+), Cu(2+), Zn(2+), Fe(2+), and Fe(3+) were determined by Fourier transform ion cyclotron resonance mass spectrometry. Complexes were of the form [PD + M + mH](5+) where PD = generation two PAMAM dendrimer with amidoethanol surface groups, M = metal ion, m = 2-4. Complementary information regarding the site and coordination chemistry of the metal ions can be obtained from the two techniques. The results suggest that complexes of Fe(3+) and Cu(2+) are coordinated via both core tertiary amines, whereas coordination of Ag(+) involves a single core tertiary amine. The Zn(2+) and Fe(2+) complexes do not appear to involve coordination by the dendrimer core.
authors.affiliation: School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom.
authors.forename: Malgorzata A
authors.initials: MA
authors.lastname: Kaczorowska
authors.forename: Helen J
authors.initials: HJ
authors.lastname: Cooper
mesh_terms: D050091:Dendrimers; D004583:Electrons; D013058:Mass Spectrometry / Q000379:methods*; D019216:Metals, Heavy / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*
chemical_list: D050091:Dendrimers; D019216:Metals, Heavy; C104700:PAMAM Starburst; D011073:Polyamines