title: A multi-center, randomized, clinical study to compare the effect and safety of autologous cultured osteoblast(Ossron) injection to treat fractures.
abstract: BACKGROUND
  We performed a multicenter, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.
  
  
  METHODS
  Sixty-four patients with long-bone fractures were randomly divided into two groups, i.e. those who received autologous cultured osteoblast injection and those who received no treatment. The sum of the difference in the callus formation scores after four and eight weeks, was used as the first efficacy variable.
  
  
  RESULTS
  The autologous cultured osteoblast injection group showed fracture healing acceleration of statistical significance, and there were no specific patient complications when using this treatment.
  
  
  CONCLUSIONS
  Autologous cultured osteoblast injection should therefore be considered as a successful treatment option for treating long-bone fracture.
authors.affiliation: Department of Orthopedic Surgery, Catholic University College of Medicine, Seoul, Korea. peter@catholic.ac.kr
authors.forename: Seok-Jung
authors.initials: SJ
authors.lastname: Kim
authors.forename: Yong-Woon
authors.initials: YW
authors.lastname: Shin
authors.forename: Kyu-Hyun
authors.initials: KH
authors.lastname: Yang
authors.forename: Sang-Bum
authors.initials: SB
authors.lastname: Kim
authors.forename: Moon-Jib
authors.initials: MJ
authors.lastname: Yoo
authors.forename: Suk-Ku
authors.initials: SK
authors.lastname: Han
authors.forename: Soo-Ah
authors.initials: SA
authors.lastname: Im
authors.forename: Yoo-Dong
authors.initials: YD
authors.lastname: Won
authors.forename: Yerl-Bo
authors.initials: YB
authors.lastname: Sung
authors.forename: Taek-Soo
authors.initials: TS
authors.lastname: Jeon
authors.forename: Cheong-Ho
authors.initials: CH
authors.lastname: Chang
authors.forename: Jae-Deog
authors.initials: JD
authors.lastname: Jang
authors.forename: Sae-Bom
authors.initials: SB
authors.lastname: Lee
authors.forename: Hyun-Cho
authors.initials: HC
authors.lastname: Kim
authors.forename: Soo-Young
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology; D002146:Bony Callus / Q000378:metabolism / Q000473:pathology; D018929:Cell Culture Techniques; D017690:Cell Transplantation; D002478:Cells, Cultured; D024042:Collagen Type I / Q000378:metabolism; D005260:Female; D017102:Fracture Healing; D050723:Fractures, Bone / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism / Q000637:transplantation*; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D024042:Collagen Type I; D000469:Alkaline Phosphatase