title: Papillary dermal elastosis: a unique elastic tissue disorder or an unusual manifestation of pseudoxanthoma elasticum-like papillary dermal elastolysis?
abstract: There are numerous acquired elastic tissue disorders, several of which present cutaneously with small yellow-to-white papules resembling plucked chicken skin. Differential diagnoses depend on the abnormalities within the network of elastic tissues. We report a case with distinct histologic features, which may represent a unique elastic tissue disorder or a variant of pseudoxanthoma elasticum-like papillary dermal elastolysis. Our patient's clinical presentation includes scattered 1-2 mm white-to-yellow papules without surface change on the upper back and neck region. Histology is characterized by foci of clumped, granular elastic tissue, which have replaced the oxytalan and elaunin fibers, alternating with foci of decreased concentrations of normal-appearing elastic fibers within the papillary dermis. Given its characteristics, we have termed this novel entity 'papillary dermal elastosis'.
authors.affiliation: Department of Dermatology, Rhode Island Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02903, USA.
authors.forename: Annie R
authors.initials: AR
authors.lastname: Wang
authors.forename: Kevan
authors.initials: K
authors.lastname: Lewis
authors.forename: Michelle
authors.initials: M
authors.lastname: Lewis
authors.forename: Leslie
authors.initials: L
authors.lastname: Robinson-Bostom
mesh_terms: D000328:Adult; D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use; D011561:Pseudoxanthoma Elasticum / Q000188:drug therapy / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy / Q000473:pathology*; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D007641:Keratolytic Agents; D014212:Tretinoin