Anti-herpes virus activity of polyether antibiotic CP-44161 in vivo.
In the previous study, we discovered a polyether antibiotic CP-44161, which was reported earlier as an anticoccidal agent, as an anti-varicella zoster virus compound. In this study, we demonstrated that CP-44161 had a very strong and broad anti-herpes virus activities against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2) in vitro. To determine the antiviral activity of CP-44161 in vivo, we examined its effect on the cutaneous HSV-2 infection model in Balb/c mice. CP-44161 showed inhibitory effect on lesion development as well as acyclovir (ACV) when the treatment was started from day 3. Meanwhile, in case the start of treatment was delayed until day 4, when ACV was no longer effective, the effectiveness of CP-44161 still remained. In this model, CP-44161 also showed inhibitory effect on the proliferation of HSV-2 DNA in dorsal root ganglia. This is the first article to report that polyether antibiotics can be effective on viral infection in vivo.
Yamagishi
Yukiko
Y
Fermentation Research Labs, Astellas Pharma Inc., Tsukuba-shi, Ibaraki, Japan. yukiko.yamagishi@jp.astellas.com
Ueno
Motoi
M
Ueno
Chihoko
C
Kato
Akemi
A
Kanasaki
Ryuichi
R
Sato
Bunji
B
Takakura
Koji
K
Fujie
Akihiko
A
Nakajima
Hidenori
H
Fujii
Takashi
T
Hino
Motohiro
M
Tsujii
Eisaku
E
D000212:Acyclovir / Q000627:therapeutic use; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D004279:DNA, Viral / Q000032:analysis / Q000096:biosynthesis / Q000235:genetics; D004987:Ethers; D005260:Female; D005663:Furans / Q000494:pharmacology* / Q000627:therapeutic use*; D005727:Ganglia, Spinal / Q000737:chemistry / Q000821:virology; D006561:Herpes Simplex / Q000188:drug therapy* / Q000821:virology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D011714:Pyrans / Q000494:pharmacology* / Q000627:therapeutic use*; D014709:Vero Cells
D000998:Antiviral Agents; D001952:Bridged-Ring Compounds; C425408:CP44,161; D004279:DNA, Viral; D004987:Ethers; D005663:Furans; D011714:Pyrans; D000212:Acyclovir