Treatment of osteoporosis with parathyroid hormone and teriparatide.
Nowadays osteoporosis treatment is based primarily on therapy with antiresorptive agents, like the bisphosphonates. Parathyroid hormone (Preotact) and human recombinant parathyroid hormone peptide 1-34 (Teriparatide) are relatively new for the treatment of osteoporosis and belong to the group of anabolic agents. Both agents demonstrated an increase in bone mineral density and a significant reduction in vertebral fractures in postmenopausal women with osteoporosis when given for 18-24 months. Data on nonvertebral fractures are, however, not clear-cut, and so far only bisphosphonates and strontium ranelate have been demonstrated to reduce all types of fractures and therefore remain the front-line option for treatment of osteoporosis. As the safety, tolerability, and cost of the therapy also influence the choice of therapy, Preotact and Teriparatide might be useful additions to the armamentarium for (second-line) treatment of osteoporosis.
Pleiner-Duxneuner
Johannes
J
4th Medicine Department, Hanusch Hospital, Ludwig Boltzmann Institute of Osteology at the Hanusch Hospital of WGKK and AUVA Trauma Centre Meidling, Vienna, Austria. johannes.pleiner@meduniwien.ac.at
Zwettler
Elisabeth
E
Paschalis
Eleftherios
E
Roschger
Paul
P
Nell-Duxneuner
Valerie
V
Klaushofer
Klaus
K
D050071:Bone Density Conservation Agents / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002118:Calcium / Q000627:therapeutic use; D018849:Controlled Clinical Trials as Topic; D005260:Female; D050723:Fractures, Bone / Q000517:prevention & control*; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D010281:Parathyroid Hormone / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019379:Teriparatide / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014807:Vitamin D / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
D050071:Bone Density Conservation Agents; D010281:Parathyroid Hormone; D014815:Vitamins; D019379:Teriparatide; D014807:Vitamin D; D002118:Calcium