title: Efficacy of five chemicals on Fasciola gigantica encysted metacercariae infectivity.
abstract: The efficacy of treating encysted metacercariae (EMC) of Fasciola gigantica with different concentrations (conc.) of acetic acid, citric acid, cetrimide, potassium permanganate and sodium hydroxide, for 15 & 30 minutes was evaluated. The efficacy of these chemicals on the vitality and infectivity of the EMC was evaluated by the development of fascioliasis infection, and the histopathological changes in the livers of experimentally infected Albino rabbits. The results showed that 1% sodium hydroxide had a lethal effect on EMC, 10% to 40% potassium permanganate destroyed the infectivity power of EMC, and acetic acid gave an adverse effect on the EMC in conc. more than 2.5%. But, neither citric acid nor cetrimide affected the vitality or infectivity of EMC and all rabbits acquired fascioliasis.
authors.affiliation: Department of Parasitology, Faculty of Veterinary Medicine, University of Cairo University, Egypt.
authors.forename: Ali Awad A
authors.initials: AA
authors.lastname: Hassan
authors.forename: Nahla M
authors.initials: NM
authors.lastname: Shoukary
authors.forename: Mona
authors.initials: M
authors.lastname: El-Motayam
authors.forename: Ayman T A
authors.initials: AT
authors.lastname: Morsy
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000494:pharmacology; D019343:Citric Acid / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005209:Fasciola / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D005211:Fascioliasis / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D010270:Parasite Egg Count; D011196:Potassium Permanganate / Q000494:pharmacology; D011817:Rabbits; D011897:Random Allocation; D012908:Snails / Q000469:parasitology; D012972:Sodium Hydroxide / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000871:Anthelmintics; D000891:Anti-Infective Agents, Local; D002593:Cetrimonium Compounds; D011196:Potassium Permanganate; D019343:Citric Acid; D012972:Sodium Hydroxide; D019342:Acetic Acid; D000077286:Cetrimonium