Polyoxygenated methyl cyclohexanoids from a terrestrial ampelomyces fungus.
Seven structurally related new polyoxygenated methyl cyclohexanoids, ampelomins A-G (1-7), were isolated from the mycelial solid culture of a soil-derived Ampelomyces fungus. Their structures were determined by spectroscopic and chemical means. Ampelomins A (1), C (3), E (5), and G (7) exhibited weak activity against alpha-glucosidase with IC(50) values of 1.74-5.93 mM, and ampelomin A (1) showed moderate antibacterial activity with MIC(90) values ranging from 202.4 to 1015.9 microM. A plausible polyketide biogenetic pathway is postulated for these compounds.
Zhang
Huiye
H
CAS Key Laboratory for Preservation and Sustainable Utilization of Plant Resources, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
Xue
Jinghua
J
Wu
Ping
P
Xu
Liangxiong
L
Xie
Haihui
H
Wei
Xiaoyi
X
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D003510:Cyclohexanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D065089:Glycoside Hydrolase Inhibitors; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D019906:Nuclear Magnetic Resonance, Biomolecular; D010100:Oxygen / Q000737:chemistry*; D010407:Penicillium / Q000201:enzymology; D011514:Proteus vulgaris / Q000187:drug effects; D027861:Prunus / Q000201:enzymology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013211:Staphylococcus aureus / Q000187:drug effects; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors
D000900:Anti-Bacterial Agents; D003510:Cyclohexanes; D065089:Glycoside Hydrolase Inhibitors; D009097:Multienzyme Complexes; C550397:ampelomin A; C039827:naringinase; D001617:beta-Glucosidase; D010100:Oxygen