Use of povidone-iodine during the first trimester of pregnancy: a correct practice?
Povidone-iodine (PVP-I) has been widely used as an antiseptic agent during invasive procedures for prenatal diagnosis. Women have been reported of thyroid dysfunction after simple exposure to PVP-I. We studied the effect on thyroid function and urinary iodine excretion after a single topical application of PVP-I in 31 women who had a miscarriage during the first trimester of pregnancy. PVP-I is absorbed through the skin and the vaginal mucosa, resulting in a sudden increase in the urinary excretion of iodine and a short-term variation in concentrations of thyroid hormones in maternal serum. This metabolic effect could have consequences for the embryo and the fetus during crucial stages of development.
Velasco
I
I
Servicio de Obstetricia y Ginecología, Hospital de Osuna, Sevilla, Spain. inesvelas@msn.com
Naranjo
S
S
López-Pedrera
C
C
Garriga
M J
MJ
García-Fuentes
E
E
Soriguer
F
F
D000022:Abortion, Spontaneous / Q000601:surgery*; D000891:Anti-Infective Agents, Local / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000652:urine; D004107:Dilatation and Curettage; D005260:Female; D006801:Humans; D011206:Povidone-Iodine / Q000009:adverse effects* / Q000493:pharmacokinetics; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D013959:Thyroid Diseases / Q000139:chemically induced*; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism
D000891:Anti-Infective Agents, Local; D011206:Povidone-Iodine; D013972:Thyrotropin; D013974:Thyroxine