title: Evaluation of three commercial latex agglutination kits and a commercial enzyme immunoassay for the detection of cryptococcal antigen.
abstract: We compared the performance of the Meridian CALAS, Wampole Crypto-LA, Murex Cryptococcus latex agglutination assay, and the Meridian Premier EIA for the detection of cryptococcal antigen in serum and CSF. The assays demonstrated similar performance characteristics based on concordance values > or = 93% but important differences were noted in endpoint titers.
authors.affiliation: Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Ngolela Esther
authors.initials: NE
authors.lastname: Babady
authors.forename: Jean E
authors.initials: JE
authors.lastname: Bestrom
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Jespersen
authors.forename: Mary F
authors.initials: MF
authors.lastname: Jones
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Beito
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Binnicker
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Wengenack
mesh_terms: D000946:Antigens, Fungal / Q000032:analysis*; D019411:Clinical Laboratory Techniques / Q000379:methods*; D003453:Cryptococcosis / Q000175:diagnosis*; D007124:Immunoenzyme Techniques / Q000379:methods; D007841:Latex Fixation Tests / Q000379:methods; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity; D044967:Serum / Q000737:chemistry* / Q000382:microbiology
chemical_list: D000946:Antigens, Fungal; D011933:Reagent Kits, Diagnostic