Cyclosporin A, but not everolimus, inhibits DNA repair in human fibroblasts and lymphoblasts.
Kuschal
C
C
Department of Dermatology and Venerology, Georg-August-University, Gottingen, Germany. ckuscha@gwdg.de
Thoms
K-M
KM
Mori
T
T
Kobayashi
N
N
Boeckmann
L
L
Laspe
P
P
Emmert
S
S
D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D016572:Cyclosporine / Q000633:toxicity*; D004249:DNA Damage / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004797:Enzyme-Linked Immunosorbent Assay; D000068338:Everolimus; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000633:toxicity*; D049409:Luciferases, Firefly / Q000235:genetics / Q000378:metabolism; D054448:Precursor Cells, B-Lymphoid / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects*; D011494:Protein Kinases / Q000187:drug effects; D011740:Pyrimidine Dimers / Q000032:analysis / Q000737:chemistry / Q000276:immunology; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D058570:TOR Serine-Threonine Kinases; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
D007166:Immunosuppressive Agents; D011740:Pyrimidine Dimers; D016572:Cyclosporine; D000068338:Everolimus; D049409:Luciferases, Firefly; D011494:Protein Kinases; C546842:MTOR protein, human; D058570:TOR Serine-Threonine Kinases; D020123:Sirolimus