Oral administration of Lactobacillus plantarum NRIC0380 suppresses IgE production and induces CD4(+)CD25(+)Foxp3(+) cells in vivo.
The influence of lactic acid bacteria (LAB) on CD4(+)Foxp3(+) cells has not been investigated, although it has been reported that CD4(+)Foxp3(+) cells might be involved in the inhibition of allergic symptoms. Hence we examined the effect of orally administered LAB on CD4(+)Foxp3(+) generation. Oral administration of Lactobacillus plantarum NRIC0380 significantly inhibited antigen-specific IgE production and enhanced the Th1 response, as some other strains reported in previous studies. The ratio of CD4(+)CD25(+)Foxp3(+) cells in whole CD4(+) cells was significantly higher in both Peyer's patch and the spleen of mice that had been fed with LAB than in the control mice.
Enomoto
Mai
M
Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Japan.
Noguchi
Sayo
S
Hattori
Makoto
M
Sugiyama
Hisashi
H
Suzuki
Yasuyuki
Y
Hanaoka
Akihiro
A
Okada
Sanae
S
Yoshida
Tadashi
T
D000284:Administration, Oral; D000818:Animals; D015704:CD4 Antigens / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism*; D048191:Lactiplantibacillus plantarum / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010581:Peyer's Patches / Q000166:cytology / Q000378:metabolism / Q000382:microbiology; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000378:metabolism / Q000382:microbiology; D018417:Th1 Cells / Q000166:cytology* / Q000276:immunology*
D015704:CD4 Antigens; D016207:Cytokines; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D053645:Interleukin-2 Receptor alpha Subunit; D007073:Immunoglobulin E