title: Pancreatitis associated with clomipramine administration in a dog.
abstract: A three-year-old, male, entire, Yorkshire terrier was presented with peracute onset of abdominal pain and vomitus. Clinicopathological abnormalities included severely increased serum lipase activity, immeasurably high serum trypsin-like immunoreactivity and mild hypocalcaemia. Canine pancreatic lipase immunoreactivity (cPLI) was intended to be measured, however, the sample got lost. Ultrasonography revealed a hypoechoic pancreas with small amounts of peripancreatic fluid and hyperechogenic mesentery. Acute pancreatitis (AP) was diagnosed and the dog recovered with appropriate therapy within 48 hours. Clomipramine, a selective serotonin reuptake inhibitor (SSRI) for alleviating signs of separation anxiety had been given for seven weeks. Two similar, albeit less severe, episodes associated with previous courses of clomipramine had occurred eight months earlier that responded to discontinuing clomipramine and supportive care. As SSRIs are associated with AP in human beings and no other trigger could be identified, we conclude that clomipramine should be considered as a potential cause when investigating causes for AP in susceptible breeds or other dogs presenting with compatible clinical signs.
authors.affiliation: Clinic for Small Animal Internal Medicine, University of Zurich, Winterthurerstr. 260, CH-8057 Zurich, Switzerland.
authors.forename: P H
authors.initials: PH
authors.lastname: Kook
authors.forename: A
authors.initials: A
authors.lastname: Kranjc
authors.forename: M
authors.initials: M
authors.lastname: Dennler
authors.forename: T M
authors.initials: TM
authors.lastname: Glaus
mesh_terms: D000818:Animals; D001010:Anxiety, Separation / Q000188:drug therapy; D002997:Clomipramine / Q000008:administration & dosage / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D004285:Dogs; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000662:veterinary*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D014463:Ultrasonography
chemical_list: D002997:Clomipramine; D017367:Selective Serotonin Reuptake Inhibitors