Seoul virus and hantavirus disease, Shenyang, People's Republic of China.
An outbreak of hemorrhagic fever with renal syndrome (HFRS) occurred among students in Shenyang Pharmaceutical University in 2006. We conducted a study to characterize etiologic agents of the outbreaks and clarify the origin of hantaviruses causing infections in humans and laboratory animals. Immunoglobulin (Ig) M or IgG antibodies against Seoul virus (SEOV) were detected in the serum samples of all 8 patients. IgG antibodies against hantavirus were also identified in laboratory rats, which were used by these students for their scientific research. Phylogenetic analysis showed that partial small segment sequences recovered from humans, laboratory rats, and local wild rats belonged to SEOV. Hantavirus sequences recovered from humans and laboratory rats clustered within 1 of 3 lineages of SEOV circulating among local wild rats in Shenyang. These results suggest that the HFRS outbreak in Shenyang was caused by SEOV that was circulating among local wild rats and had also infected the laboratory rats.
Zhang
Yong-Zhen
YZ
Chinese Center for Disease Control and Prevention, Beijing, People's Republic of China. yongzhenzhang@sohu.com
Dong
Xue
X
Li
Xin
X
Ma
Chao
C
Xiong
Hai-Ping
HP
Yan
Guang-Jie
GJ
Gao
Na
N
Jiang
Dong-Mei
DM
Li
Ming-Hui
MH
Li
Lu-Ping
LP
Zou
Yang
Y
Plyusnin
Alexander
A
D000328:Adult; D000818:Animals; D000830:Animals, Laboratory / Q000821:virology; D000835:Animals, Wild / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D005260:Female; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051189:Murinae / Q000821:virology; D010802:Phylogeny; D051381:Rats; D017208:Rats, Wistar; D012376:Rodent Diseases / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D029263:Seoul virus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D013334:Students; D014495:Universities; D055815:Young Adult; D015047:Zoonoses / Q000453:epidemiology / Q000635:transmission / Q000821:virology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M