DSB proteins and bacterial pathogenicity.
If DNA is the information of life, then proteins are the machines of life--but they must be assembled and correctly folded to function. A key step in the protein-folding pathway is the introduction of disulphide bonds between cysteine residues in a process called oxidative protein folding. Many bacteria use an oxidative protein-folding machinery to assemble proteins that are essential for cell integrity and to produce virulence factors. Although our current knowledge of this machinery stems largely from Escherichia coli K-12, this view must now be adjusted to encompass the wider range of disulphide catalytic systems present in bacteria.
Heras
Begoña
B
The University of Queensland, Institute for Molecular Bioscience, Queensland 4072, Australia. b.heras@imb.uq.edu.au
Shouldice
Stephen R
SR
Totsika
Makrina
M
Scanlon
Martin J
MJ
Schembri
Mark A
MA
Martin
Jennifer L
JL
D001419:Bacteria / Q000201:enzymology / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D019295:Computational Biology; D004220:Disulfides / Q000378:metabolism*; D048168:Escherichia coli K12 / Q000201:enzymology / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000502:physiology*; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology*; D010084:Oxidation-Reduction; D010802:Phylogeny; D019704:Protein Disulfide-Isomerases / Q000737:chemistry / Q000502:physiology*; D017510:Protein Folding; D055550:Protein Stability; D014774:Virulence
D001426:Bacterial Proteins; D004220:Disulfides; C079503:DsbB protein, Bacteria; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D019704:Protein Disulfide-Isomerases; C526648:dsbA protein, E coli