Churg-Strauss syndrome associated with acalculous cholecystitis and liver involvement.
We describe a 65-year-old man who had liver involvement with Churg-Strauss syndrome. He was admitted to the hospital because of fever, weight loss, dyspnea, abdominal pain, skin lesions and paraesthesias. His past medical history revealed a diagnosis of acalculous cholecystitis that had been made eight months earlier. Microscopic examination of a gall bladder biopsy specimen obtained at that time revealed an increase in extravascular eosinophils. There was evidence of a new bilateral pulmonary disease with bronchoconstriction and a transient infiltrated lesion in the right upper lung. The patient's white cell count was 14 620 per cubic millimetre, with 39% eosinophils (5800 per cubic millimetre) and 39% neutrophils. IgE was 503 g/L (normal range, 0 to 100 g/L). Liver function tests were mildly elevated. Fine needle liver biopsy showed active interface hepatitis. A diagnosis of Churg-Strauss syndrome was made. In this patient the syndrome occurred in a rare association with hepatitis, likely due to immunologic events in the liver. The patient was successfully treated with 60 mg/day of prednisolone monotherapy.
Yüksel
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I
Department of Gastroenterology, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey. yukselilhami@hotmail.com
Ataseven
H
H
Başar
O
O
Köklü
S
S
Ertuğrul
I
I
Ibiş
M
M
Temuçin
T
T
Saşmaz
N
N
D042101:Acalculous Cholecystitis / Q000150:complications*; D000368:Aged; D015267:Churg-Strauss Syndrome / Q000150:complications*; D006505:Hepatitis / Q000150:complications*; D006801:Humans; D008297:Male