title: Plasma derivatives and strategies for reaching self-sufficiency in Liguria: the role of the Transfusion Medicine Service of the Gaslini Institute.
abstract: BACKGROUND
  Since 2002, Liguria has been part of the Interregional Agreement on Plasma Derivatives (AIP) stipulated among some Regions of north Italy with the aim of contributing to self-sufficiency of the interregional system through exchanges between the facilities lacking products and those with an excess. In Liguria , the management of plasma derivates is entrusted to the Regional Centre for Co-ordination and Compensation (CRCC) which, with strategies of compensation, tries to guarantee that the needs for plasma derivates are covered in the hospitals in its territory. The Services of Immunohaematology and Transfusion Medicine (SIMT) have a goal of increasing the production of plasma in order to participate actively in achieving regional self-sufficiency.
  
  
  METHODS
  The SIMT of the G. Gaslini Institute introduced some strategies aimed at reaching this goal. The increase in the number of donations made with a cell separator, the introduction of multicomponent donations of plasma and platelets and the collection of high concentration platelet concentrates led to a considerable increase category A plasma sent for fractioning. Finally, the implementation of shared guidelines on the use of blood components enabled the clinical use of the plasma collected to be kept under control.
  
  
  CONCLUSIONS
  The analysis of the trends of consumption of the most widely used plasma derivatives showed an increase in the overall demands, which can be attributed to the paediatric focus of our hospital and to its highly specialised wards. ON THE BASIS OF THE INDUSTRIAL TECHNICAL YIELD, IT WAS POSSIBLE TO CALCULATE THE THEORETICAL COVERAGE OF THE REQUIREMENTS FOR PLASMA: this highlighted a better theoretical coverage for albumin but a shortfall of intravenous immunoglobulins. The amount of plasma necessary to meet the theoretical needs was calculated for each plasma derivative, revealing that the derivative requiring the greatest volume of plasma is intravenous immunoglobulins. This finding confirms the change in the "driving product": it is now the consumption of intravenous immunoglobulins that determines the amount of plasma that is sent for industrial processing.
authors.affiliation: Servizio di Immunoematologia e Medicina Trasfusionale, Istituto Giannina Gaslini,Genova.
authors.forename: Laura
authors.initials: L
authors.lastname: Bocciardo
authors.forename: Marina
authors.initials: M
authors.lastname: Martinengo
authors.forename: Diego
authors.initials: D
authors.lastname: Ardenghi
authors.forename: Tullia
authors.initials: T
authors.lastname: Emanueli
authors.forename: Enrica
authors.initials: E
authors.lastname: Oliva
authors.forename: Gino
authors.initials: G
authors.lastname: Tripodi