The impact of obesity on outcomes after critical illness: a meta-analysis.
OBJECTIVE
To assess whether obesity is associated with mortality or other adverse intensive care unit (ICU) and post-ICU outcomes.


METHODS
A meta-analysis of studies from PubMed and EMBASE databases.


RESULTS
Twenty-two studies (n = 88,051 patients) were included. Pooled analysis demonstrated no difference in ICU mortality, but lower hospital mortality for obese and morbidly obese subjects (RR 0.76; 95% CI 0.59, 0.92; RR 0.83; 95% CI 0.66, 1.04, respectively) versus normal weight subjects. There was no association between obesity and duration of mechanical ventilation or ICU stay. Morbidly obese versus normal weight patients had longer hospitalizations. No study reported physical function, mental health, or quality of life outcomes after discharge.


CONCLUSIONS
Obesity is not associated with increased risk for ICU mortality, but may be associated with lower hospital mortality. There is a critical lack of research on how obesity may affect complications of critical illness and patient long-term outcomes.
Hogue
Charles W
CW
Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. chogue2@jhmi.edu
Stearns
Joshua D
JD
Colantuoni
Elizabeth
E
Robinson
Karen A
KA
Stierer
Tracey
T
Mitter
Nanhi
N
Pronovost
Peter J
PJ
Needham
Dale M
DM
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016638:Critical Illness / Q000401:mortality*; D006801:Humans; D007362:Intensive Care Units; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D016896:Treatment Outcome; D055815:Young Adult