An amino acid shuffle activates mTORC1.
The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.
Cohen
Adiel
A
Biozentrum, University of Basel, Basel, Switzerland.
Hall
Michael N
MN
D000818:Animals; D001343:Autophagy; D005973:Glutamine / Q000378:metabolism*; D006801:Humans; D027283:Large Neutral Amino Acid-Transporter 1 / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes; D011494:Protein Kinases / Q000378:metabolism*; D011506:Proteins; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors / Q000378:metabolism
D027283:Large Neutral Amino Acid-Transporter 1; D046912:Multiprotein Complexes; D011506:Proteins; D014157:Transcription Factors; D005973:Glutamine; D011494:Protein Kinases; C546842:MTOR protein, human; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases