The diffusive interaction of microtubule binding proteins.
Microtubule-based motility is often thought of as specifically referring to the directed stepping of microtubule-based motors such as kinesin or dynein. However, microtubule lattice diffusion (also known as diffusional motility) provides a second mode of transport that is shared by a much broader class of microtubule binding proteins. Microtubule lattice diffusion offers distinct advantages as a transport mechanism including speed, bidirectional microtubule end targeting, and no requirement for direct chemical energy (i.e. ATP). It remains to be seen whether a universal binding mechanism for this interaction will be identified but electrostatic interactions appear to play a significant role. In the meantime, the well-studied subject of DNA binding proteins that diffuse along the DNA backbone provides an insightful analog for understanding the nature of microtubule-based diffusional motility.
Cooper
Jeremy R
JR
Department of Physiology and Biophysics, University of Washington School of Medicine, Seattle, WA 98195, USA.
Wordeman
Linda
L
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D008868:Microtubule Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological
D004268:DNA-Binding Proteins; D008868:Microtubule Proteins