Levofloxacin-induced delirium.
An 83-year-old man was admitted for right lower lobe pneumonia which did not improve after a 5-day outpatient treatment with amoxicillin/clavulinate and clarithromycin. An empiric treatment with levofloxacin was started with a significant improvement after 24 h of this treatment. On the third day of hospitalization, delirium developed, while the patient was afebrile and with normal blood oxygenation. Treatment with levofloxacin was stopped, and a complete resolution of the patient's delirium was observed 2 days later. To the best of our knowledge, this is the third case of levofloxacin-induced delirium described in the medical literature.
Slobodin
Gleb
G
Department of Internal Medicine A, Bnai Zion Medical Center, P.O. Box 6477, 31063, Haifa, Israel.
Elias
Nizar
N
Zaygraikin
Natalia
N
Sheikh-Ahmad
Muhammad
M
Sabetay
Sergiu
S
Weller
Boaz
B
Odeh
Majed
M
D000367:Age Factors; D000369:Aged, 80 and over; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D017291:Clarithromycin / Q000627:therapeutic use; D003221:Confusion / Q000139:chemically induced; D003693:Delirium / Q000139:chemically induced* / Q000503:physiopathology; D000077727:Ertapenem; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000009:adverse effects*; D011014:Pneumonia / Q000188:drug therapy*; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D028761:Withholding Treatment; D047090:beta-Lactams / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D064704:Levofloxacin; D000658:Amoxicillin; D015242:Ofloxacin; D000077727:Ertapenem; D017291:Clarithromycin