title: Long-term disease control of refractory anaplastic large cell lymphoma with vinblastine.
abstract: Anaplastic large cell lymphoma (ALCL) is a unique clinical and pathologic subtype of lymphoma characterized by the proliferation of large, highly pleomorphic CD30-positive cells. Overall 70% to 80% of children with ALCL are cured with modern chemotherapy regimens, but the disease is often resistant to multiple therapies after relapse. Single agent vinblastine therapy has been effective in some cases of refractory ALCL. We report a case of ALCL originally diagnosed in an 8-year-old girl. After relapse, the disease was refractory to multiagent chemotherapy, but has showed remarkable response to, and dependence on, single agent vinblastine treatment for almost 7 years.
authors.affiliation: Department of Pediatrics, University of Florida College of Medicine, Gainesville, FL, USA.
authors.forename: Rachel
authors.initials: R
authors.lastname: Garner
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Brian
authors.initials: B
authors.lastname: Gray
authors.forename: Robert
authors.initials: R
authors.lastname: Zori
authors.forename: Raul
authors.initials: R
authors.lastname: Braylan
authors.forename: Judith
authors.initials: J
authors.lastname: Wall
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Hunger
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D005260:Female; D006801:Humans; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy*; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D016879:Salvage Therapy; D014747:Vinblastine / Q000627:therapeutic use*
chemical_list: D014747:Vinblastine