title: Synthesis of some N, n'-diacylhydrazine derivatives with radical-scavenging and antifungal activity.
abstract: A series of N,N'-diacylhydrazines were prepared and their structures were confirmed by 1H NMR, MS and FTICR-MS. They were tested radical-scavenging activity in vitro. The preliminary bioassays of title compounds showed that two compounds had excellent radical-scavenging activity comparable with vitamin C, while the activity is highly relative to the substituents. Surprisingly, several compounds also exhibit favorable fungicidal activities. To further explore the comprehensive structure-activity relationships about the fungicidal activity, a three-dimensional quantitative structure-activity relationship analysis using the method of comparative molecular field analysis was performed.
authors.affiliation: State-Key Laboratory of Elemento-Organic Chemistry, National Pesticide Engineering Research Center (Tianjin), Nankai University, Tianjin 300071, China.
authors.forename: Xing-Hai
authors.initials: XH
authors.lastname: Liu
authors.forename: Yan-Xia
authors.initials: YX
authors.lastname: Shi
authors.forename: Yi
authors.initials: Y
authors.lastname: Ma
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: He
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Dong
authors.forename: Chuan-Yu
authors.initials: CY
authors.lastname: Zhang
authors.forename: Bao-Lei
authors.initials: BL
authors.lastname: Wang
authors.forename: Su-Hua
authors.initials: SH
authors.lastname: Wang
authors.forename: Bao-Ju
authors.initials: BJ
authors.lastname: Li
authors.forename: Zheng-Ming
authors.initials: ZM
authors.lastname: Li
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008956:Models, Chemical; D021281:Quantitative Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D016166:Free Radical Scavengers; D006834:Hydrazines; D001205:Ascorbic Acid