title: Reducing the rates of indeterminate results of the QuantiFERON-TB Gold In-Tube test during routine preemployment screening for latent tuberculosis infection among healthcare personnel.
abstract: We implemented the QuantiFERON-TB Gold (QFT-G) In-Tube test to identify latent tuberculosis infection among potential employees prior to employment. The rates of indeterminate QFT-G In-Tube test results were higher than expected and prompted an investigation that led to successful interventions (eg, manual vortexing before incubation and the use of a modified in-tube method). The tracking of indeterminate results is suggested as an important quality control measure.
authors.affiliation: Department of Infectious Disease, Cleveland Clinic, Cleveland, Ohio, USA. mirandc@ccf.org
authors.forename: Cyndee
authors.initials: C
authors.lastname: Miranda
authors.forename: Belinda
authors.initials: B
authors.lastname: Yen-Lieberman
authors.forename: Paul
authors.initials: P
authors.lastname: Terpeluk
authors.forename: J Walton
authors.initials: JW
authors.lastname: Tomford
authors.forename: Steven
authors.initials: S
authors.lastname: Gordon
mesh_terms: D003955:Diagnostic Tests, Routine / Q000379:methods / Q000592:standards*; D006282:Health Personnel; D006801:Humans; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014374:Tuberculin Test / Q000379:methods / Q000592:standards*; D014376:Tuberculosis / Q000097:blood / Q000175:diagnosis* / Q000382:microbiology / Q000635:transmission