Exploring pluripotency with chemical genetics.
In a recent issue of Chemistry & Biology, Bone et al. (2009) employed a chemical biology approach to probe the role of glycogen synthase kinase-3 (GSK-3), a key regulator of pluripotentiality, providing new insights and tools for modulating this process.
Doble
Bradley W
BW
McMaster Stem Cell and Cancer Research Institute, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada.
Woodgett
James R
JR
D000818:Animals; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D006801:Humans; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D051176:beta Catenin / Q000378:metabolism
D004791:Enzyme Inhibitors; D051176:beta Catenin; D038362:Glycogen Synthase Kinase 3