MDMA reinstates cocaine-seeking behaviour in mice.
BACKGROUND
MDMA effects are mediated by monoaminergic systems, which seem to play a central role in cocaine craving and relapse.


METHODS
CD1 mice trained to self-administer cocaine (1 mg/kg/infusion) underwent an extinction procedure in which the cues contingent with drug self-administration remained present. Mice achieving extinction were injected with MDMA (10 mg/kg), d-amphetamine (1 and 2 mg/kg) or saline and tested for reinstatement.


RESULTS
Acute MDMA, but not d-amphetamine or saline reinstated cocaine-seeking behaviour in mice in which cocaine self-administration and contingent cues were previously extinguished.


CONCLUSIONS
Acute MDMA can reinstate cocaine-seeking behaviour in mice.
Trigo
José Manuel
JM
Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salud, Universitat Pompeu Fabra, Calle Dr. Aiguader 88, 08003 Barcelona, Spain. jose.trigo@upf.edu
Orejarena
Maria Juliana
MJ
Maldonado
Rafael
R
Robledo
Patricia
P
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003042:Cocaine / Q000008:administration & dosage* / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000503:physiopathology*; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D003913:Dextroamphetamine / Q000009:adverse effects; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects*; D012646:Self Administration; D018490:Serotonin Agents / Q000009:adverse effects*
D018765:Dopamine Uptake Inhibitors; D018490:Serotonin Agents; D003042:Cocaine; D018817:N-Methyl-3,4-methylenedioxyamphetamine; D003913:Dextroamphetamine