title: Immunological effects of stress in psoriasis.
abstract: BACKGROUND
  Psychological stress causes phenotypic changes in circulating lymphocytes and is regarded as an important trigger of the Th1-polarized inflammatory skin disease psoriasis.
  
  
  OBJECTIVE
  To study the effects of psychological stress on immunological parameters, i.e. membrane molecules relevant to the pathophysiology of psoriasis, especially cutaneous lymphocyte-associated antigens (CLA) involved in T and natural killer (NK) cells homing in on the skin.
  
  
  METHODS
  The severity of psoriasis was assessed in patients using the Psoriasis Area and Severity Index. Patients with psoriasis (n=15) and healthy volunteers (n=15) were exposed to brief psychological stress in the laboratory. In vitro analyses were conducted 1 h before, immediately following and 1 h after stress exposure. Peripheral T- and NK-cell subsets including CD8+ T lymphocytes, CLA+ lymphocytes and lymphocyte function-associated antigen type 1 (LFA-1)+ lymphocytes were analysed by flow cytometry.
  
  
  RESULTS
  We found a significant stress-induced increase of CD3+ T lymphocytes in patients with psoriasis only. Analyses of T-cell subsets revealed that this increase was observable for cytotoxic CD8+ T lymphocytes and CLA+ CD3+ lymphocytes. The total number of circulating NK cells (CD16+, CD56+) increased immediately after stress in both groups whereas only patients with psoriasis showed a significant increase in CLA+ NK cells.
  
  
  CONCLUSIONS
  A higher stress-induced increase of CLA+ T and CLA+ NK cells in the circulation of patients with psoriasis might point to an increased ability of T and NK cells in the presence of psoriasis to home in on the skin during mental stress. Further studies are needed to verify these relationships in more detail and to investigate the time point at which these cells accumulate within lesional skin, and whether or not psychotherapy improves the quality of life of patients with psoriasis and influences stress-dependent parameters.
authors.affiliation: Department of Psychosomatic Medicine, Hannover Medical School, Hannover, Germany. Schmid-Ott.Gerhard@mh-hannover.de
authors.forename: G
authors.initials: G
authors.lastname: Schmid-Ott
authors.forename: B
authors.initials: B
authors.lastname: Jaeger
authors.forename: T
authors.initials: T
authors.lastname: Boehm
authors.forename: K
authors.initials: K
authors.lastname: Langer
authors.forename: M
authors.initials: M
authors.lastname: Stephan
authors.forename: U
authors.initials: U
authors.lastname: Raap
authors.forename: T
authors.initials: T
authors.lastname: Werfel
mesh_terms: D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D011565:Psoriasis / Q000276:immunology / Q000523:psychology*; D012720:Severity of Illness Index; D012867:Skin / Q000276:immunology*; D013315:Stress, Psychological / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology