The stem of cancer.
Despite great advances in our understanding of tumor initiation and progression, the identity of the "cell of origin" of cancer remains elusive. Two recent publications provide experimental evidence that normal intestinal stem cells are the cells of origin of intestinal cancer in the mouse.
Fodde
Riccardo
R
Department of Pathology, Josephine Nefkens Institute, Erasmus Medical Center, Rotterdam, The Netherlands. r.fodde@erasmusmc.nl
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology* / Q000502:physiology; D051379:Mice; D009369:Neoplasms / Q000473:pathology / Q000503:physiopathology; D014411:Neoplastic Stem Cells / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000502:physiology*
D014408:Biomarkers, Tumor; C493597:Lgr5 protein, mouse; D043562:Receptors, G-Protein-Coupled