White matter anisotropy and depression symptoms in patients with HIV.
HIV is associated with increased risk for depression. Normal appearing white matter (NAWM) fractional anisotropy in 15 HIV-seropositive (HIV+) adults with depressive symptoms was compared to 15 HIV+ adults without depressive symptoms. HIV+ adults with depressive symptoms showed increased NAWM fractional anisotropy within the left thalamus, the temporal, and frontal regions, as well as the right cingulate. Discrete components of depression were associated with distinct regional NAWM fractional anisotropy increases. These results demonstrate altered neural complexity in HIV+ adults with depressive symptoms and support the notion that depression is multifactorial with different morphological alterations contributing to discrete aspects of depression.
Smith
Clifford A
CA
Rush University Medical Center, Chicago, IL, USA. clifford.smith2@va.gov
Stebbins
Glenn T
GT
Bartt
Russell E
RE
Kessler
Harold A
HA
Adeyemi
Oluwatoyin M
OM
Martin
Eileen
E
Bammer
Roland
R
Moseley
Michael E
ME
D000328:Adult; D000339:Affect; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D018791:CD4 Lymphocyte Count; D003866:Depressive Disorder / Q000473:pathology* / Q000523:psychology*; D005260:Female; D015658:HIV Infections / Q000473:pathology* / Q000523:psychology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012959:Socioeconomic Factors