Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery.
Drug delivery, magnetic resonance and fluorescence imaging, magnetic manipulation, and cell targeting are simultaneously possible using a multifunctional mesoporous silica nanoparticle. Superparamagnetic iron oxide nanocrystals were encapsulated inside mesostructured silica spheres that were labeled with fluorescent dye molecules and coated with hydrophilic groups to prevent aggregation. Water-insoluble anticancer drugs were delivered into human cancer cells; surface conjugation with cancer-specific targeting agents increased the uptake into cancer cells relative to that in non-cancerous fibroblasts. The highly versatile multifunctional nanoparticles could potentially be used for simultaneous imaging and therapeutic applications.
Liong
Monty
M
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, USA.
Lu
Jie
J
Kovochich
Michael
M
Xia
Tian
T
Ruehm
Stefan G
SG
Nel
Andre E
AE
Tamanoi
Fuyuhiko
F
Zink
Jeffrey I
JI
D003287:Contrast Media; D003460:Crystallization / Q000639:trends; D016503:Drug Delivery Systems / Q000639:trends*; D007089:Image Enhancement / Q000379:methods*; D007287:Inorganic Chemicals / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry / Q000627:therapeutic use / Q000648:ultrastructure; D036103:Nanotechnology / Q000639:trends*; D010316:Particle Size
D003287:Contrast Media; D007287:Inorganic Chemicals