[Study on stability of curcumine, demethoxycurcumin and bisdemethoxycurcumin].
OBJECTIVE
To investigate the stability of curcumin, demethoxycurcumin and bisdemethoxycurcumin in different buffer solution.


METHODS
To determine concentration of curcumin by HPLC when added curcumin, demethoxycurcumin and bisdemethoxycurcumin into the buffer solution the equation of degradation was established.


RESULTS
The sequence of stability are bisdemethoxycurcumin > or = demethoxycurcumin > or =curcumin at the same condition.


CONCLUSIONS
The demethoxycurcumin can stabilize curcumin more strong than the others. The demethoxycurcumin is a nature stabilizing agent for curcumin.
Han
Gang
G
Pharmaceutical Department, North China Coal Medical University, Tangshan 063000, China. tsyxhg@163.com
Cui
Jing-jing
JJ
Bi
Rui
R
Zhao
Lin-lin
LL
Zhang
Wei-guo
WG
D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry*; D036381:Diarylheptanoids; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration
D036381:Diarylheptanoids; C034786:bisdemethoxycurcumin; D003474:Curcumin; C050229:demethoxycurcumin