title: Phenylpropanoid and lignan derivatives from Antiaris toxicaria and their effects on proliferation and differentiation of an osteoblast-like cell line.
abstract: Antiarisin A and B (1 and 2), together with seventeen known compounds (3-19), were isolated from the EtOAc extract of the stem of Antiaris toxicaria Lesch. Their structures were determined on the basis of spectroscopic analyses and chemical methods. Most of the compounds were reported for the first time from the Antiaris genus and firstly studied for their proliferative and differentiative activity on osteoblast-like cells. Screening results indicated that, at the concentration of 10(-8) M, benzofuran lignans 5, 6, 11 and 13 could significantly stimulate the proliferation of UMR106 cells, while 8, 9, 11, 14, 15 and 17 could enhance ALP (alkaline phosphatase) activity.
authors.affiliation: Central Laboratory of Guangdong Pharmaceutical University, Guangzhou, PR China.
authors.forename: Miao-Miao
authors.initials: MM
authors.lastname: Jiang
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Yi
authors.initials: Y
authors.lastname: Dai
authors.forename: Xue
authors.initials: X
authors.lastname: Zhang
authors.forename: Nai-Li
authors.initials: NL
authors.lastname: Wang
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000818:Animals; D031621:Antiaris / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004958:Estradiol; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010006:Osteoblasts; D020005:Propanols / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; D020005:Propanols; D004958:Estradiol