title: Mitochondria and aging: innocent bystanders or guilty parties?
abstract: There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. However, there is little evidence that these mutations could affect the functioning of aging tissues.
authors.affiliation: Department of Genetics and Biotechnology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Tońska
authors.forename: A
authors.initials: A
authors.lastname: Sołyga
authors.forename: E
authors.initials: E
authors.lastname: Bartnik
mesh_terms: D000375:Aging; D000818:Animals; D017209:Apoptosis; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D017353:Gene Deletion; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D018384:Oxidative Stress / Q000235:genetics; D012867:Skin / Q000473:pathology; D015595:Skin Aging
chemical_list: D004272:DNA, Mitochondrial