Plasma 3-nitrotyrosine, urinary 8-isoprostane and 8-OHdG among healthy Japanese people.
To examine the relation between lifestyle factors and oxidative stress biomarkers, this study analysed plasma 3-nitrotyrosine (3-NT), urinary 8-isoprostane and 8-hydroxy-2'- deoxyguanosine (8-OHdG) of 323 healthy Japanese without any disease. Plasma 3-NT was significantly increased by excessive exercise (p=0.010), but it was not significantly different in terms of sex, age (< 40, >==40), BMI (<18.5, 18.5-24.9, >==25.0), smoking (non-smokers, smokers) and alcohol drinking per week (non-drinkers, <10 units, >==10 units). Urinary 8-isoprostane was significantly associated with alcohol drinking (p <0.01) and sex (p <0.01), although it had no significant relevance to age and exercise. Moreover, urinary 8-OHdG was positively associated with age (p <0.05) and negatively associated with BMI (p <0.05) and fasting insulin (p <0.001). However, it was not related with sex, smoking, alcohol drinking and exercise. In conclusion, the present results suggest that 3-NT, 8-isoprostane and 8-OHdG seem to be useful biomarkers for early prediction of lifestyle-related disease risk at the population level.
Sakano
Noriko
N
Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Takahashi
Noriko
N
Wang
Da-Hong
DH
Sauriasari
Rani
R
Takemoto
Kei
K
Kanbara
Sakiko
S
Sato
Yoshie
Y
Takigawa
Tomoko
T
Takaki
Jiro
J
Ogino
Keiki
K
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D007564:Japan; D008019:Life Style; D008297:Male; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species; D012307:Risk Factors; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood; D055815:Young Adult
D015415:Biomarkers; D017382:Reactive Oxygen Species; C075750:8-epi-prostaglandin F2alpha; C002744:3-nitrotyrosine; D014443:Tyrosine; D000080242:8-Hydroxy-2'-Deoxyguanosine; D015237:Dinoprost; D003849:Deoxyguanosine