title: Caboxamycin, a new antibiotic of the benzoxazole family produced by the deep-sea strain Streptomyces sp. NTK 937.
abstract: Caboxamycin, a new benzoxazole antibiotic, was detected by HPLC-diode array screening in extracts of the marine strain Streptomyces sp. NTK 937, which was isolated from deep-sea sediment collected in the Canary Basin. The structure of caboxamycin was determined by mass spectrometry, NMR experiments and X-ray analysis. It showed inhibitory activity against Gram-positive bacteria, selected human tumor cell lines and the enzyme phosphodiesterase.
authors.affiliation: Mikrobiologisches Institut, Universität Tübingen, Tübingen, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Hohmann
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schneider
authors.forename: Christina
authors.initials: C
authors.lastname: Bruntner
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Irran
authors.forename: Graeme
authors.initials: G
authors.lastname: Nicholson
authors.forename: Alan T
authors.initials: AT
authors.lastname: Bull
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Jones
authors.forename: Roselyn
authors.initials: R
authors.lastname: Brown
authors.forename: James E M
authors.initials: JE
authors.lastname: Stach
authors.forename: Michael
authors.initials: M
authors.lastname: Goodfellow
authors.forename: Winfried
authors.initials: W
authors.lastname: Beil
authors.forename: Marco
authors.initials: M
authors.lastname: Krämer
authors.forename: Johannes F
authors.initials: JF
authors.lastname: Imhoff
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Fiedler
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001583:Benzoxazoles / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D012623:Seawater / Q000382:microbiology; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism*; D014871:Water Microbiology
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001583:Benzoxazoles; C544384:caboxamycin