Pregnancy-associated plasma protein-A and C-reactive protein levels in pre-eclamptic and normotensive pregnant women at third trimester.
OBJECTIVE
The aim of this study was to determine the levels of plasma pregnancy-associated plasma protein-A (PAPP-A) and C-reactive protein (CRP) in pre-eclampsia and their association with the mean arterial blood pressure (MAP).


METHODS
Sixty-seven women with pre-eclampsia symptoms were matched with 56 normal pregnant controls for gestational age, maternal age and parity. Both of the groups were third trimester. PAPP-A and CRP were measured in serum using chemiluminescence assay and nephelometry, respectively.


RESULTS
Maternal serum levels of PAPP-A and CRP were increased in women with pre-eclampsia compared to controls. There were significant correlations between MAP and CRP (r = 0.372, P = 0.002) and MAP and PAPP-A parameters (r = 0.301, P = 0.013) in pregnancies complicated with pre-eclampsia. PAPP-A had no correlation with CRP in patients with pre-eclampsia and in normotensive pregnant women.


CONCLUSIONS
We found higher levels of PAPP-A and CRP and the presence of a good correlation between CRP and MAP in pre-eclampsia.
Deveci
Koksal
K
Department of Biochemistry and Clinical Biochemistry, Ataturk Training Hospital, Izmir, Turkey. drkdeveci@gmail.com
Sogut
Erkan
E
Evliyaoglu
Osman
O
Duras
Nuriye
N
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011446:Prospective Studies
D002097:C-Reactive Protein; D011266:Pregnancy-Associated Plasma Protein-A