title: Cyclotriphosphazene ring as a platform for multiporphyrin assemblies.
abstract: A simple method has been employed to synthesize a cyclotriphosphazene appended with six porphyrins. The reaction of one equivalent of hexachlorocyclotriphosphazene with six equivalents of 5-(4-hydroxyphenyl)-10,15,20-tri(p-tolyl)porphyrin or -21-thiaporphyrin in tetrahydrofuran in the presence of cesium carbonate, followed by simple column-chromatography purification, afforded the hexaporphyrinato cyclotriphosphazene systems as the single products in 80-90 % yields. The metal(II) derivatives (Cu(II), Zn(II)) of the hexaporphyrinato cyclotriphosphazene systems were prepared by treating the hexaporphyrin assemblies with the appropriate metal salts under standard metallation conditions. The compounds are freely soluble in common organic solvents and were characterized by mass spectrometry, NMR, absorption, and fluorescence spectroscopy, and electrochemical techniques. Material studies carried out by using fluorescence microscopy, SEM, and AFM techniques showed that the hexaporphyrinato cyclotriphosphazene systems form ringlike architectures. Preliminary biological studies indicate that the hexacopper(II) porphyrin assembly can be used as an artificial nuclease.
authors.affiliation: Department of Chemistry, Indian Institute of Technology, Bombay, Powai, Mumbai, India.
authors.forename: M Rajeswara
authors.initials: MR
authors.lastname: Rao
authors.forename: G
authors.initials: G
authors.lastname: Gayatri
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: G Narahari
authors.initials: GN
authors.lastname: Sastry
authors.forename: M
authors.initials: M
authors.lastname: Ravikanth