title: Membranoproliferative glomerulonephritis associated with a mutation in Wilms' tumour suppressor gene 1.
abstract: Wilms' tumour suppressor gene 1 (WT1) encodes a transcription factor required for normal development of the genitourinary system. In the kidney, mutations in WT1 can cause diffuse mesangial sclerosis or focal segmental glomerulosclerosis. Here, we report on a girl with a mutation in WT1, who developed membranoproliferative glomerulonephritis (MPGN) 3 years after completion of treatment for Wilms' tumour. This finding extends the spectrum of glomerular disease seen with WT1 mutations and could have implications for the screening of children with MPGN.
authors.affiliation: Nephrology, Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK. Detlef.Bockenhauer@nhs.net
authors.forename: Detlef
authors.initials: D
authors.lastname: Bockenhauer
authors.forename: William
authors.initials: W
authors.lastname: van't Hoff
authors.forename: Gil
authors.initials: G
authors.lastname: Chernin
authors.forename: Saskia F
authors.initials: SF
authors.lastname: Heeringa
authors.forename: Neil J
authors.initials: NJ
authors.lastname: Sebire
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D016162:Genes, Wilms Tumor; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000235:genetics* / Q000503:physiopathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D016030:Kidney Transplantation; D009154:Mutation; D009392:Nephrectomy; D014750:Vincristine / Q000627:therapeutic use; D009396:Wilms Tumor / Q000150:complications / Q000235:genetics / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D014750:Vincristine