The beta cell population in type 1 diabetes.
Type 1 diabetes is often considered as a disease where more than 90% of the beta cells have been destroyed at clinical onset and where beta cell antigen-driven autoimmune reactivities progressively destroy remaining beta cells as well as newly formed or implanted beta cells. This view will be evaluated in light of histological observations in the pancreas of type 1 diabetic patients and of antibody-positive non-diabetic organ donors.
Pipeleers
Daniel
D
Diabetes Research Center at Brussels Free University-VUB, JDRF Center for Beta Cell Therapy in Diabetes, Laarbeeklaan 103, 1090 Brussels, Belgium.
In't Veld
Peter
P
Pipeleers-Marichal
Miriam
M
Gorus
Frans
F
D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism; D002470:Cell Survival; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000473:pathology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology
D001323:Autoantibodies; D015395:Histocompatibility Antigens Class I