title: Depression in schizophrenia: methodological artifact or distinct feature of the illness?
abstract: In schizophrenia, there is a conceptual overlap between depressive and negative symptoms. This study examined the dimensional structure of depressive symptoms and their overlap with negative symptoms in a large sample of older medicated schizophrenia outpatients. Self-reported depression was obtained with the Beck Depression Inventory-II (BDI-II). Three components from this scale (i.e., dysphoria, psychosomatic and regret domains) showed excellent factorability and good consistency. However, adequate construct validity and correlates with outcomes were found for the dysphoria and regret domains, but not for the total score or the psychosomatic domain. Thus, the evaluation of domains within the BDI-II provides a more pure and clinically-relevant assessment of depressed mood in schizophrenia than the use of this scale as a whole.
authors.affiliation: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA. eran.chemerinski@mssm.edu
authors.forename: Eran
authors.initials: E
authors.lastname: Chemerinski
authors.forename: Christopher
authors.initials: C
authors.lastname: Bowie
authors.forename: Hannah
authors.initials: H
authors.lastname: Anderson
authors.forename: Philip D
authors.initials: PD
authors.lastname: Harvey
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D003071:Cognition / Q000502:physiology; D003627:Data Interpretation, Statistical; D003866:Depressive Disorder / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance / Q000502:physiology; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy; D012565:Schizophrenic Psychology; D012919:Social Behavior
chemical_list: D014150:Antipsychotic Agents