title: The MLLgnant consequences of reverting to an embryonic transcriptional program.
abstract: In this issue of Cell Stem Cell, Somervaille et al. (2009) have demonstrated convincingly that reversion to an embryonic transcriptional program through defective MLL gene expression contributes to the generation of myeloid leukemia stem cells.
authors.affiliation: Stem Cell Research Program, Division of Hematology/Oncology, Moores UCSD Cancer Center, University of California-San Diego, 3855 Health Sciences Drive, La Jolla, CA 92093, USA. cjamieson@ucsd.edu
authors.forename: Catriona
authors.initials: C
authors.lastname: Jamieson
mesh_terms: D000818:Animals; D065150:Cellular Reprogramming; D018507:Gene Expression Regulation, Developmental; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology / Q000503:physiopathology; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000502:physiology*; D014158:Transcription, Genetic
chemical_list: C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase