FRAX and its applications to clinical practice.
The introduction of the WHO FRAX algorithms has facilitated the assessment of fracture risk on the basis of fracture probability. FRAX integrates the influence of several well validated risk factors for fracture with or without the use of BMD. Its use in fracture risk prediction poses challenges for patient assessment, the development of practice guidelines, the evaluation of drug efficacy and reimbursement, as well as for health economics which are the topics outlined in this review.
Kanis
John A
JA
WHO Collaborating Centre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
Oden
Anders
A
Johansson
Helena
H
Borgström
Fredrik
F
Ström
Oskar
O
McCloskey
Eugene
E
D000465:Algorithms; D015992:Body Mass Index; D005260:Female; D050723:Fractures, Bone; D006801:Humans; D008297:Male; D012307:Risk Factors