True osseous metaplasia of the endometrium: the bone is not from a fetus.
OBJECTIVE
To identify the origin of calcified tissue in endometrial ossification.


METHODS
DNA analyses from the ossified tissue and from the woman were studied to compare both genotypes.


METHODS
University and general hospitals.


METHODS
A 27-year-old infertile woman diagnosed of osseous metaplasia of the endometrium.


METHODS
Hysteroscopic resection of the endometrial osseous metaplasia for DNA analysis.


METHODS
DNA comparison between the patient and the osseous tissue extracted from the uterus.


RESULTS
All markers produced the same allele length for both blood and endometrial biopsy (including bones), thus confirming the same genetic origin.


CONCLUSIONS
Endometrial ossification is derived from the patient, resulting in a true osseous metaplasia.
Cayuela
Enrique
E
Obstetrics and Gynecology Department, Hospital General Hospitalet, Barcelona, Spain.
Perez-Medina
Tirso
T
Vilanova
Joan
J
Alejo
Maria
M
Cañadas
Paz
P
D000028:Abortion, Induced / Q000009:adverse effects; D000328:Adult; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D004717:Endometrium / Q000473:pathology*; D005260:Female; D005333:Fetus / Q000378:metabolism / Q000473:pathology*; D005838:Genotype; D006801:Humans; D007247:Infertility, Female / Q000175:diagnosis / Q000209:etiology; D008679:Metaplasia / Q000175:diagnosis / Q000235:genetics; D009999:Ossification, Heterotopic / Q000175:diagnosis* / Q000235:genetics