Oxiranyl anion methodology using microflow systems.
Deprotonation of epoxides followed by trapping with electrophiles was carried out using microflow systems with varying temperature and residence time. Time-dependence of the yields of products provides a deeper insight into chemical and configurational stabilities of oxiranyllithiums. With the thus-obtained information, reactions of oxiranyllithiums with various electrophiles were successfully carried out without decomposition and isomerization.
Nagaki
Aiichiro
A
Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
Takizawa
Eiji
E
Yoshida
Jun-ichi
J