title: New model for assembly dynamics of bacterial tubulin in relation to the stages of DNA replication.
abstract: How living cells receive their genome through cell division has been one of the important questions of biology. In prokaryotes, cell division starts with formation of a ring-shaped microtubule-like structure, FtsZ-ring, at the potential division site. All the previous models suggested that FtsZ-ring is formed coupling to termination or far after initiation of DNA replication. In contrast, we demonstrated that a close communication with DNA replication is maintained throughout the cell cycle. FtsZ starts to assemble to the cell center coupling to initiation of DNA replication, and stabilizes as FtsZ-ring at its termination, but does not constrict before separation of nucleoids. This combination of a positive and a negative control would guarantee that a successful replication event would inevitably induce one cell division such that each of the daughter cells would receive one and only one daughter nucleoid.
authors.affiliation: National Institute of Genetics, Research Organization of Information and Systems, Mishima, Shizuoka 411-8540, Japan.
authors.forename: Ippei
authors.initials: I
authors.lastname: Inoue
authors.forename: Reiko
authors.initials: R
authors.lastname: Ino
authors.forename: Akiko
authors.initials: A
authors.lastname: Nishimura
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D002876:Chromosomes, Bacterial / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D004261:DNA Replication; D004926:Escherichia coli / Q000166:cytology* / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D008954:Models, Biological
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C071525:FtsZ protein, Bacteria