Alpha-methyldopa hepatotoxicity in pregnancy.
A 12-week pregnant, 33-year-old African American female, presented with jaundice and change in urine colour. Liver function tests revealed raised transamines and normal alkaline phosphatase. She was started on methyldopa 6 weeks prior to presentation. After initial negative investigations including viral and autoimmune hepatitis, she was given prednisone for methyldopa induced hepatitis. Two weeks later, repeat enzymes revealed normal values. Important clinical and management points related to methyldopa induced hepatotoxicity are discussed.
Ali
Tauseef
T
Department of Gastroenterology, University of Oklahoma, Oklahoma City, USA. tauseef-ali@ouhsc.edu
Srinivasan
Nandakumar
N
Le
Vu
V
Rizvi
Syed
S
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007565:Jaundice / Q000139:chemically induced; D008111:Liver Function Tests; D008750:Methyldopa / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D000959:Antihypertensive Agents; D008750:Methyldopa; D011241:Prednisone