Tropomyosin as a regulator of cancer cell transformation.
Tropomyosins (Tms) are among the most studied structural proteins of the actin cytoskeleton that are implicated in neoplastic-specific alterations in actin filament organization. Decreased expression of specific nonmuscle Tm isoforms is commonly associated with the transformed phenotype. These changes in Tm expression appear to contribute to the rearrangement of microfilament bundles and morphological alterations, increased cell motility and oncogenic signaling properties of transformed cells. Below we review aspects of Tm biology as it specifically relates to transformation and cancer including its expression in culture models of transformed cells and human tumors, mechanisms that regulate Tm expression and the role of Tm in oncogenic signaling.
Helfman
David M
DM
Department of Cell Biology and Anatomy, Sylvester Comprehensive Cancer Center, Leonard M. Miller School of Medicine, Papanicolaou Building, Room 317, 1550 NW 10th Avenue (M-877), Miami, Florida 33136, USA. dhelfman@med.miami.edu
Flynn
Patrick
P
Khan
Protiti
P
Saeed
Ali
A
D000199:Actins / Q000737:chemistry; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002461:Cell Line, Transformed; D002465:Cell Movement; D002471:Cell Transformation, Neoplastic; D003599:Cytoskeleton / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000378:metabolism*; D020033:Protein Isoforms; D015398:Signal Transduction; D014335:Tropomyosin / Q000737:chemistry*
D000199:Actins; D014408:Biomarkers, Tumor; D020033:Protein Isoforms; D014335:Tropomyosin