title: Resting heart rate does not reflect the degree of beta-blockade in subjects with heart failure on chronic beta-blocker therapy.
abstract: We investigated the relationship between resting heart rate (HR) and two measures of beta-1 receptor sensitivity/blockade: (1) the percentage of maximal predicted heart rate reached during exercise (%MPHR), and (2) the HR increase per unit of circulating norepinephrine (NE) or the chronotropic responsiveness index (CRI) in 28 patients with systolic CHF on chronic beta-blocker therapy. Our results show that resting HR is not associated with HR response during exercise nor with beta-1 receptor sensitivity to circulating NE.
authors.affiliation: Department of Medicine, Division of Cardiology, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Andrea
authors.initials: A
authors.lastname: Mignatti
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Sims
authors.forename: Paolo C
authors.initials: PC
authors.lastname: Colombo
authors.forename: Luis I
authors.initials: LI
authors.lastname: Garcia
authors.forename: Rachel
authors.initials: R
authors.lastname: Bijou
authors.forename: Mario C
authors.initials: MC
authors.lastname: Deng
authors.forename: Ulrich P
authors.initials: UP
authors.lastname: Jorde
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D005080:Exercise Test; D017079:Exercise Tolerance / Q000187:drug effects*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D017410:Practice Guidelines as Topic; D016896:Treatment Outcome
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D000319:Adrenergic beta-Antagonists; D015415:Biomarkers; D009638:Norepinephrine