[Inflammatory changes in obese adipose tissue].
Evidence has accumulated suggesting that obesity is a state of chronic, low grade inflammation; it may represent a potential mechanism whereby obesity leads to the metabolic derangements. To understand the molecular mechanism underlying the development of obesity and obesity-related metabolic syndrome, it is of great use to divide the obesity-related 'adipose tissue remodeling' into three phases; 1) adipocyte proliferation and hypertrophy, 2) macrophage infiltration, and 3) adipocyte-macrophage interaction. Elucidation of the molecular mechanism underlying the inflammatory changes in each phase of the obesity-related 'adipose tissue remodeling' may lead to the identification of new therapeutic targets that may reduce obesity-induced inflammatory changes and thus the metabolic syndrome.
Ito
Ayaka
A
Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University.
Suganami
Takayoshi
T
Ogawa
Yoshihiro
Y
D017667:Adipocytes / Q000473:pathology; D000273:Adipose Tissue / Q000473:pathology*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D008264:Macrophages / Q000473:pathology; D009765:Obesity / Q000473:pathology*