title: Clinical and diagnostic features of delayed hypoxic leukoencephalopathy.
abstract: Delayed hypoxic leukoencephalopathy is an underrecognized syndrome of delayed demyelination, which is important to consider when delayed onset of neuropsychiatric symptoms follows a hypoxic event. The authors describe clinical and diagnostic features of three such cases, review the pathophysiology of delayed hypoxic leukoencephalopathy, and discuss features which may help distinguish it from toxic leukoencephalopathy.
authors.affiliation: University of Rochester, Department of Neurology, 1351 Mt. Hope Ave, Suite 100, Rochester, NY 14620-3917, USA. David_Shprecher@urmc.rochester.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Shprecher
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Flanigan
authors.forename: A Gordon
authors.initials: AG
authors.lastname: Smith
authors.forename: Shawn M
authors.initials: SM
authors.lastname: Smith
authors.forename: Thomas
authors.initials: T
authors.lastname: Schenkenberg
authors.forename: John
authors.initials: J
authors.lastname: Steffens
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000506:poisoning; D001569:Benzodiazepines / Q000506:poisoning; D001921:Brain / Q000473:pathology*; D003042:Cocaine / Q000506:poisoning; D003072:Cognition Disorders / Q000209:etiology / Q000473:pathology; D003865:Major Depressive Disorder / Q000473:pathology / Q000523:psychology; D062787:Drug Overdose; D005260:Female; D005283:Fentanyl / Q000506:poisoning; D005356:Fibromyalgia / Q000188:drug therapy / Q000523:psychology; D020233:Gait Disorders, Neurologic / Q000139:chemically induced / Q000473:pathology; D006801:Humans; D002534:Hypoxia, Brain / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D008691:Methadone / Q000506:poisoning; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009292:Narcotic Antagonists / Q000506:poisoning; D009483:Neuropsychological Tests; D011605:Psychoses, Substance-Induced / Q000473:pathology / Q000523:psychology; D013406:Suicide, Attempted
chemical_list: D000701:Analgesics, Opioid; D009292:Narcotic Antagonists; D001569:Benzodiazepines; D003042:Cocaine; D008691:Methadone; D005283:Fentanyl