title: Expression of vascular endothelial growth factor receptors in the endometrium of septate uterus.
abstract: OBJECTIVE
  To compare the messenger RNA (mRNA) expression of vascular endothelial growth factor (VEGF) receptors (KDR, Flt-1, and sflt) in the different endometrial locations of septate uterus and normal uterus.
  
  
  METHODS
  Prospective, observational study.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  Twelve women with complete septate uterus undergoing hysteroscopic metroplasty and 12 women with normal uterus.
  
  
  METHODS
  Endometrial tissue samples were obtained from the endometrium covering the septum and the endometrium lining the lateral wall of the uterus. Moreover, endometrial samples were obtained from patients with normal uterus.
  
  
  METHODS
  Differences in the mRNA expression of VEGF receptors between the endometrial samples of septate and normal uterus.
  
  
  RESULTS
  The mRNA expression of VEGF receptors, both KDR and Flt-1, was significantly lower in the endometrium lining the septum as compared with the endometrium covering the lateral wall of septate and normal uterus. Conversely, no differences were observed in mRNA expression in the soluble receptor sflt between the different endometrial samples studied.
  
  
  CONCLUSIONS
  The results suggest that a local defect of both VEGF transmembranous receptors (KDR and Flt-1) in the endometrium covering the septal area may be responsible for the clinical comportment of this müllerian anomaly.
authors.affiliation: Departamento de Pediatria, Obstetricia y Ginecología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain; Hospital Clínico Universitario, Valencia, Spain. Electronic address: raga_fra@gva.es.
authors.forename: Francisco
authors.initials: F
authors.lastname: Raga
authors.affiliation: Hospital Clínico Universitario, Valencia, Spain.
authors.forename: Eva Maria
authors.initials: EM
authors.lastname: Casañ
authors.affiliation: Departamento de Pediatria, Obstetricia y Ginecología, Facultad de Medicina, Universidad de Valencia, Valencia, Spain; Hospital Clínico Universitario, Valencia, Spain.
authors.forename: Fernando
authors.initials: F
authors.lastname: Bonilla-Musoles
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D011446:Prospective Studies; D012333:RNA, Messenger / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor / Q000235:genetics / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000235:genetics / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000235:genetics / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; C501162:FLT1 protein, human; D040262:Receptors, Vascular Endothelial Growth Factor; D040281:Vascular Endothelial Growth Factor Receptor-1; D040301:Vascular Endothelial Growth Factor Receptor-2