title: Detox agents do not affect the pharmacokinetics of methamphetamine in the rat.
abstract: Recently, 'detox' agents have been popularly used as forms of diets or nutritional supplements. Especially, several cases have been reported that these detox agents have been used to mask drug tests among drug abusers. In the present study, capsule and drink types of detox agents were evaluated for their ability to alter the elimination of methamphetamine (MA) in rats. For this study, MA and its major metabolite, amphetamine (AP) in urine samples were determined using LC-tandem mass spectrometry after administration of the detox agents to MA-treated rats. As a result, significant differences were not shown between control and detox-dosed groups in the amounts of MA and AP excreted into urine as well as the volume of excreted urine. This result suggests that the detox agents tested may not affect the metabolism or elimination of MA and further might have minimal effect on narcotics detection in the urine samples of drug abusers.
authors.affiliation: Doping Control Center, Korea Institute of Science and Technology, PO Box 131, Chungryang, Seoul, Republic of Korea.
authors.forename: Sang Kyu
authors.initials: SK
authors.lastname: Lee
authors.forename: Yoon
authors.initials: Y
authors.lastname: Kim
authors.forename: Sungill
authors.initials: S
authors.lastname: Suh
authors.forename: Yong Jun
authors.initials: YJ
authors.lastname: Suh
authors.forename: Moon Kyo
authors.initials: MK
authors.lastname: In
authors.forename: Dong-Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Changbae
authors.initials: C
authors.lastname: Jin
authors.forename: Hye Hyun
authors.initials: HH
authors.lastname: Yoo
mesh_terms: D000661:Amphetamine / Q000652:urine; D000818:Animals; D000697:Central Nervous System Stimulants / Q000493:pharmacokinetics* / Q000652:urine; D002853:Chromatography, Liquid; D053593:Forensic Toxicology; D008297:Male; D008694:Methamphetamine / Q000493:pharmacokinetics* / Q000652:urine; D009292:Narcotic Antagonists / Q000494:pharmacology*; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D053719:Tandem Mass Spectrometry; D014815:Vitamins / Q000494:pharmacology
chemical_list: D000697:Central Nervous System Stimulants; D009292:Narcotic Antagonists; D014815:Vitamins; D008694:Methamphetamine; D000661:Amphetamine