Heterotopic osteogenesis by murine demineralized incisors at lesions sites induced by concanavalin a in mice.
The aim of this study was to examine the effects of Concanavalin A (Con A) administration on the early (preosteogenic) and late stages of osteogenesis induced by implantation of demineralized murine incisors into syngeneic mice. Local administration of Con A resulted in an increased yield of demineralized incisor-induced bone when injected during the preosteogenic stage of induction. This effect was not observed when Con A was injected after heterotopic osteogenesis had been established. This suggests that Con A recruits osteoprogenitor cells, but does not stimulate differentiated chondroblasts and osteoblasts.
Włodarski
Paweł K
PK
Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland. krzysztof.wlodarski@wum.edu.pl
Galus
Ryszard
R
Włodarski
Krzysztof H
KH
Brodzikowska
Aniela
A
D000818:Animals; D003208:Concanavalin A / Q000008:administration & dosage / Q000494:pharmacology*; D007180:Incisor / Q000502:physiology*; D007274:Injections, Intraperitoneal; D051379:Mice; D008807:Mice, Inbred BALB C; D009999:Ossification, Heterotopic / Q000139:chemically induced*; D010012:Osteogenesis / Q000187:drug effects* / Q000502:physiology
D003208:Concanavalin A