Erythrocyte membrane permeability in the men with metastatic adenocarcinoma of the prostate.
The aim of our study was to investigate the alterations of the erythrocyte membrane permeability in the men with metastatic adenocarcinoma of the prostate before and six months after castration. For experimental research were used the erythrocytes of 15 men with metastatic prostate cancer (Pca) (before and after 6 months from castration) and of the 15 practically healthy men (control group). The patients age was vacillate from 60 to 75 years old. Clinical stage of the disease was established at A. Tsulukidze National Center of Urology. Investigations revealed the changes of Na(+)/K(+)-ATP-ase activity and the changes of Na(+) and K(+) ions concentration in metastatic Pca patients before and six months after castration. It was determined that after the castration alterations of the erythrocytes transportive function is less pronounced in comparison with pre-operational data; These indicate the overall improvement of the organism's condition in the post-operational period and partial recovery of the cellular homeostasis.
Veshapidze
N
N
Iv. Javakhishvili Tbilisi State University, Faculty of Exact and Natural sciences.
Alibegashvili
M
M
Gabunia
N
N
Ramishvili
L
L
Kotrikadze
N
N
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000368:Aged; D002463:Cell Membrane Permeability / Q000502:physiology*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000378:metabolism; D017136:Ion Transport / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011188:Potassium / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium