title: Combined autologous cellular cardiomyoplasty using skeletal myoblasts and bone marrow cells for human ischemic cardiomyopathy with left ventricular assist system implantation: report of a case.
abstract: Myocardial regeneration therapy shows great promise as a treatment for heart failure. We recently introduced combined autologous cellular cardiomyoplasty with skeletal myoblasts and bone marrow cells as a treatment for human ischemic cardiomyopathy. We report the results of our first clinical trial of this technique, used to treat a patient with severe heart failure caused by ischemic cardiomyopathy who was being managed with a left ventricular assist system (LVAS). After combined cell transplantation, the patient showed signs of improved cardiac performance and angiogenesis, and reduced fibrosis.
authors.affiliation: Division of Cardiovascular Surgery, Department of Surgery, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, Suita, Osaka, 565-0871, Japan.
authors.forename: Shigeru
authors.initials: S
authors.lastname: Miyagawa
authors.forename: Goro
authors.initials: G
authors.lastname: Matsumiya
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Funatsu
authors.forename: Masao
authors.initials: M
authors.lastname: Yoshitatsu
authors.forename: Naozumi
authors.initials: N
authors.lastname: Sekiya
authors.forename: Shinya
authors.initials: S
authors.lastname: Fukui
authors.forename: Takaya
authors.initials: T
authors.lastname: Hoashi
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Hori
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Kanakura
authors.forename: Jun
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Aozasa
authors.forename: Naomasa
authors.initials: N
authors.lastname: Kawaguchi
authors.forename: Nariaki
authors.initials: N
authors.lastname: Matsuura
authors.forename: Akira
authors.initials: A
authors.lastname: Myoui
authors.forename: Akifumi
authors.initials: A
authors.lastname: Matsuyama
authors.forename: Sachiko
authors.initials: S
authors.lastname: Ezoe
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Iida
authors.forename: Hikaru
authors.initials: H
authors.lastname: Matsuda
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Sawa
mesh_terms: D016026:Bone Marrow Transplantation; D009202:Cardiomyopathies / Q000601:surgery*; D018421:Cardiomyoplasty / Q000379:methods*; D017809:Fatal Outcome; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D008875:Middle Aged; D032448:Myoblasts, Skeletal / Q000637:transplantation*; D017202:Myocardial Ischemia / Q000601:surgery*; D014182:Transplantation, Autologous