Detection of circulating autoantibodies against thyroid hormones in an infant with permanent congenital hypothyroidism and her twin with transient congenital hypothyroidism: possible contribution of thyroid hormone autoantibodies to neonatal and infant hypothyroidism.
Premature, very-low-birth-weight female twins were diagnosed with congenital hypothyroidism (CH). Thyroid hormone antibodies (THAb) directed against triiodothyronine (T3) and thyroxine (T4) of both the IgM and IgG class were detected in both twins. At age 10 months, a rise in thyroid stimulating hormone (TSH) occurred in both infants and measurement of THAb at the same time revealed the appearance of IgM-T4 and IgG-T4 and an increase in IgG-T3 levels in twin 1 (permanent CH), and with a slight increase of IgM-T4 and IgG-T4 levels and appearance of IgM-T3 in twin 2 (transient CH). THAb may contribute to the induction of hypothyroidism in neonates and infants, especially those with underlying autoimmune thyroid disease.
Benvenga
Salvatore
S
Sezione di Endocrinologia, Dipartimento Clinico Sperimentale di Medicina e Farmacologia, Policlinico Universitario di Messina, Italy.
Ordookhani
Arash
A
Pearce
Elizabeth N
EN
Tonacchera
Massimo
M
Azizi
Fereidoun
F
Braverman
Lewis E
LE
D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000097:blood / Q000235:genetics; D001827:Body Height; D001835:Body Weight; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000097:blood / Q000276:immunology* / Q000473:pathology; D004200:Diseases in Twins; D000074623:Dual Oxidases; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D019102:Infant, Very Low Birth Weight; D007453:Iodide Peroxidase / Q000097:blood / Q000235:genetics; D033862:Iron-Binding Proteins / Q000097:blood / Q000235:genetics; D019255:NADPH Oxidases / Q000097:blood / Q000235:genetics; D047928:Premature Birth; D013963:Thyroid Hormones / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000276:immunology; D014284:Triiodothyronine / Q000276:immunology; D014430:Twins, Monozygotic
D001323:Autoantibodies; D001324:Autoantigens; D007136:Immunoglobulins; D033862:Iron-Binding Proteins; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D000074623:Dual Oxidases; C056658:TPO protein, human; D007453:Iodide Peroxidase; D019255:NADPH Oxidases; C431515:DUOX2 protein, human; D013974:Thyroxine