title: Shearwave dispersion ultrasound vibrometry (SDUV) for measuring tissue elasticity and viscosity.
abstract: Characterization of tissue elasticity (stiffness) and viscosity has important medical applications because these properties are closely related to pathological changes. Quantitative measurement is more suitable than qualitative measurement (i.e., mapping with a relative scale) of tissue viscoelasticity for diagnosis of diffuse diseases where abnormality is not confined to a local region and there is no normal background tissue to provide contrast. Shearwave dispersion ultrasound vibrometry (SDUV) uses shear wave propagation speed measured in tissue at multiple frequencies (typically in the range of hundreds of Hertz) to solve quantitatively for both tissue elasticity and viscosity. A shear wave is stimulated within the tissue by an ultrasound push beam and monitored by a separate ultrasound detect beam. The phase difference of the shear wave between 2 locations along its propagation path is used to calculate shear wave speed within the tissue. In vitro SDUV measurements along and across bovine striated muscle fibers show results of tissue elasticity and viscosity close to literature values. An intermittent pulse sequence is developed to allow one array transducer for both push and detect function. Feasibility of this pulse sequence is demonstrated by in vivo SDUV measurements in swine liver using a dual transducer prototype simulating the operation of a single array transducer.
authors.affiliation: Department of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, MN, USA.
authors.forename: Shigao
authors.initials: S
authors.lastname: Chen
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Urban
authors.forename: Cristina
authors.initials: C
authors.lastname: Pislaru
authors.forename: Randall
authors.initials: R
authors.lastname: Kinnick
authors.forename: Yi
authors.initials: Y
authors.lastname: Zheng
authors.forename: Aiping
authors.initials: A
authors.lastname: Yao
authors.forename: James F
authors.initials: JF
authors.lastname: Greenleaf
mesh_terms: D000465:Algorithms; D000818:Animals; D002417:Cattle; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D004867:Equipment Design; D005240:Feasibility Studies; D008099:Liver / Q000000981:diagnostic imaging / Q000502:physiology*; D054792:Muscle, Striated / Q000000981:diagnostic imaging / Q000502:physiology*; D013552:Swine; D014159:Transducers; D014732:Vibration; D014783:Viscosity