[Role of acetylcholine in the Ca2+-dependent regulation of functional activity of myocardium of frog Rana temporaria].
To study role of ACh in the Ca2+-dependent regulation of rhythm and strength of cardiac contractions in frog Rana temporaria, the ACh chrono- and inotropic effects have been studied in parallel experiments on the background of blockers of potential-controlled Ca2+-channels, ryanodine and muscarine receptors. The obtained results indicate participation of acetylcholine in the Ca2+-dependent regulation of rhythm and strength of frog cardiac contractions.
Shemarova
I V
IV
Kuznetsov
S V
SV
Demina
I N
IN
Nesterov
V P
VP
D000109:Acetylcholine / Q000494:pharmacology*; D029845:Amphibian Proteins / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D018678:Cholinergic Agents / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D011896:Rana temporaria; D011976:Receptors, Muscarinic / Q000378:metabolism; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*
D029845:Amphibian Proteins; D018678:Cholinergic Agents; D011976:Receptors, Muscarinic; D019837:Ryanodine Receptor Calcium Release Channel; D000109:Acetylcholine; D002118:Calcium