title: Low-glycaemic index sweetener-based beverages reduce 24-h glucose profiles in healthy adults.
abstract: BACKGROUND
  Previous research has shown that substitution of high-glycaemic index (GI) bread for low-GI bread can favourably alter the 24-h glucose profile. Given the high beverage consumption in the UK, the present study aimed to evaluate the impact of consuming a beverage containing a low-GI, natural sweetener at mealtimes compared to a sucrose-based beverage, on the 24-h glucose profile.
  
  
  METHODS
  In a randomized crossover design, six subjects (aged 41 +/- 16 years; body mass index = 25.8 +/- 4.1 kg m(-2)) were provided with a diet including low-GI or control (sucrose) beverages on two nonconsecutive days. On each study day, subjects consumed the low-GI or control beverage at breakfast, lunch and dinner. Interstitial glucose concentrations were measured over 24 h using a continuous glucose monitoring system.
  
  
  RESULTS
  Compared to the control beverage, the low-GI beverage significantly reduced mean glucose concentration over 24 h (P < 0.05). Similarly, 24-h and daytime incremental area under the curves for glucose were significantly lower (P = 0.001).
  
  
  CONCLUSIONS
  The substitution of a sucrose-based beverage for a beverage containing a low-GI, natural sweetener at mealtimes is a simple dietary change that can significantly reduce 24-h glucose levels and may be beneficial for many individuals.
authors.affiliation: Nutrition and Food Research Group, School of Life Sciences, Oxford Brookes University, Oxford, UK. jhenry@brookes.ac.uk
authors.forename: C J K
authors.initials: CJ
authors.lastname: Henry
authors.forename: K J
authors.initials: KJ
authors.lastname: Newens
authors.forename: H J
authors.initials: HJ
authors.lastname: Lightowler
mesh_terms: D000328:Adult; D019540:Area Under Curve; D001628:Beverages; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D018592:Cross-Over Studies; D019422:Dietary Sucrose / Q000493:pharmacokinetics*; D005260:Female; D038321:Glycemic Index / Q000502:physiology*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male
chemical_list: D001786:Blood Glucose; D019422:Dietary Sucrose