Flavonoids protect against intercellular adhesion molecule-1 induction by benzo[a]pyrene.
Dietary changes are an attractive means of protecting against environmental chemical exposure. Exposure to benzo[a]pyrene (B[a]P) is a risk factor for cardiovascular disease events. It has recently been shown that B[a]P can increase intercellular adhesion molecule-1 (ICAM-1) in endothelial cells, a possible means of promoting cardiovascular disease. This study investigated the ability of flavonoids to protect against B[a]P-induced ICAM-1. It was shown that only flavonoids that contain a 4' B-ring hydroxyl substitution and a 2-3 C-ring double bond were protective. These data suggest that selected bioactive compounds can decrease proinflammatory properties of environmental chemicals such as B[a]P.
Owens
Elizabeth Oesterling
EO
Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536-0200, USA.
Toborek
Michal
M
Hennig
Bernhard
B
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D001564:Benzo(a)pyrene / Q000633:toxicity*; D002274:Carcinogens, Environmental / Q000633:toxicity*; D002478:Cells, Cultured; D019610:Cytoprotection; D004032:Diet; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008954:Models, Biological
D000975:Antioxidants; D002274:Carcinogens, Environmental; D005419:Flavonoids; D018799:Intercellular Adhesion Molecule-1; D001564:Benzo(a)pyrene