title: Sex hormone-binding globulin levels predict insulin sensitivity, disposition index, and cardiovascular risk during puberty.
abstract: OBJECTIVE
  Early puberty is associated with increased risk of subsequent cardiovascular disease. Low sex hormone-binding globulin (SHBG) levels are a feature of early puberty and of conditions associated with increased cardiovascular risk. The aim of the present study was to evaluate SHBG as a predictor of glucose metabolism and metabolic risk during puberty.
  
  
  METHODS
  This was a cross-sectional study on 132 healthy Caucasian children and adolescents evaluated by an oral glucose tolerance test, a dual-energy X-ray absorptiometry scan, direct oxygen uptake measurement during cycle ergometry, and fasting blood samples.
  
  
  RESULTS
  SHBG levels declined with advancement of puberty in both boys (P < 0.001) and girls (P = 0.019). SHBG was significantly positively associated with insulin sensitivity in boys (P < 0.001) and girls (P < 0.001). In addition, SHBG was a strong predictor of insulin sensitivity (P = 0.001) and the only predictor of the disposition index (P = 0.031) after adjustment for puberty, fat mass, and aerobic fitness. SHBG was significantly negatively associated with metabolic risk (P = 0.032) and with hypersensitive C-reactive protein levels (P = 0.030) after adjustment for relevant confounders.
  
  
  CONCLUSIONS
  SHBG was a strong predictor of insulin sensitivity and metabolic risk during puberty. Thus, we hypothesize that SHBG integrates the marked changes in glucose metabolism and body composition that occur during the pubertal transition.
authors.affiliation: Department of Growth and Reproduction, Copenhagen University Hospital, Copenhagen, Denmark. kaspar.soerensen@rh.regionh.dk
authors.forename: Kaspar
authors.initials: K
authors.lastname: Sørensen
authors.forename: Lise
authors.initials: L
authors.lastname: Aksglaede
authors.forename: Thor
authors.initials: T
authors.lastname: Munch-Andersen
authors.forename: Niels Jacob
authors.initials: NJ
authors.lastname: Aachmann-Andersen
authors.forename: Joergen Holm
authors.initials: JH
authors.lastname: Petersen
authors.forename: Linda
authors.initials: L
authors.lastname: Hilsted
authors.forename: Jørn Wulff
authors.initials: JW
authors.lastname: Helge
authors.forename: Anders
authors.initials: A
authors.lastname: Juul
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D002097:C-Reactive Protein / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002648:Child; D003430:Cross-Sectional Studies; D003718:Denmark; D005080:Exercise Test; D005260:Female; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology; D010101:Oxygen Consumption; D010809:Physical Fitness; D011627:Puberty; D012042:Registries; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D044465:White People
chemical_list: D001786:Blood Glucose; D007328:Insulin; D012738:Sex Hormone-Binding Globulin; D002097:C-Reactive Protein