The polymorphisms of interleukin 17A (IL17A) gene and its association with pediatric asthma in Taiwanese population.
BACKGROUND
The interleukin 17A (IL17A) gene, located on chromosome 6p and linked to asthma phenotype, is a highly potential candidate gene conferring asthma susceptibility. The purpose of this study was to investigate the genetic association between single nucleotide polymorphisms (SNPs) of IL17A and asthma in Taiwanese children.


METHODS
We selected and performed genotyping on nine SNPs that encompass the genomic region of IL17A in Taiwanese children with or without asthma. A total of 1939 subjects containing 1027 subjects in testing group and 931 subjects in validation group were recruited in this study.


RESULTS
After Bonferroni correction, SNP rs8193036 was found to have a weak association (P = 0.0074 x 9 = 0.066) in genotype frequency test. This association was confirmed by validation group. Logistic regression adjusted allergy comorbidity and gender showed a slightly weaker association.


CONCLUSIONS
The results indicated an independent role of IL17A promoter polymorphism rs8193036 in the association with pediatric asthma in Taiwanese population.
Wang
J Y
JY
Department of Pediatrics, College of Medicine, National Cheng-Kung University, Tainan.
Shyur
S D
SD
Wang
W H
WH
Liou
Y H
YH
Lin
C G J
CG
Wu
Y J
YJ
Wu
L S H
LS
D000293:Adolescent; D001249:Asthma / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics* / Q000276:immunology; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan / Q000453:epidemiology
D020381:Interleukin-17