title: Regulation of different inflammatory diseases by impacting the mevalonate pathway.
abstract: The 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors (statins) interfere with the mevalonate pathway. While initially developed for their lipid-lowering properties, statins have been extensively investigated with respect to their impact on autoantigen and alloantigen driven immune responses. Mechanistically it was shown that statins modify immune responses on several levels, including effects on dendritic cells, endothelial cells, macrophages, B cells and T cells. Several lines of evidence suggest that statins act in a disease-specific manner and are not effective in each immune disorder. This review discusses possible modes of action of statins in modulating immunity towards autoantigens and alloantigens.
authors.affiliation: Department of Haematology and Oncology, Albert-Ludwigs-University Freiburg, Freiburg, Germany. robert.zeiser@uniklinik-freiburg.de
authors.forename: Robert
authors.initials: R
authors.lastname: Zeiser
authors.forename: Kristina
authors.initials: K
authors.lastname: Maas
authors.forename: Sawsan
authors.initials: S
authors.lastname: Youssef
authors.forename: Christoph
authors.initials: C
authors.lastname: Dürr
authors.forename: Lawrence
authors.initials: L
authors.lastname: Steinman
authors.forename: Robert S
authors.initials: RS
authors.lastname: Negrin
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology; D015551:Autoimmunity / Q000187:drug effects; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D008798:Mevalonic Acid / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007155:Immunologic Factors; D008798:Mevalonic Acid