Aquaporin-2 in the "-omics" era.
Vasopressin controls renal water excretion largely through actions to regulate the water channel aquaporin-2 in collecting duct principal cells. Our knowledge of the mechanisms involved has increased markedly in recent years with the advent of methods for large-scale systems-level profiling such as protein mass spectrometry, yeast two-hybrid analysis, and oligonucleotide microarrays. Here we review this progress.
Hoffert
Jason D
JD
Laboratory of Kidney and Electrolyte Metabolism, NHLBI, National Institutes of Health, Bethesda, Maryland 20892-1603, USA.
Chou
Chung-Lin
CL
Knepper
Mark A
MA
D000595:Amino Acid Sequence; D000818:Animals; D051399:Aquaporin 2 / Q000737:chemistry / Q000378:metabolism*; D001127:Arginine Vasopressin / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D020869:Gene Expression Profiling; D006801:Humans; D007685:Kidney Tubules, Collecting / Q000378:metabolism; D008969:Molecular Sequence Data; D040901:Proteomics
D051399:Aquaporin 2; D001127:Arginine Vasopressin