Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats.
The vagal afferent pathway is important in short-term regulation of food intake, and decreased activation of this neural pathway with long-term ingestion of a high-fat diet may contribute to hyperphagic weight gain. We tested the hypothesis that expression of genes encoding receptors for orexigenic factors in vagal afferent neurons are increased by long-term ingestion of a high-fat diet, thus supporting orexigenic signals from the gut. Obesity-prone (DIO-P) rats fed a high-fat diet showed increased body weight and hyperleptinemia compared with low-fat diet-fed controls and high-fat diet-induced obesity-resistant (DIO-R) rats. Expression of the type I cannabinoid receptor and growth hormone secretagogue receptor 1a in the nodose ganglia was increased in DIO-P compared with low-fat diet-fed controls or DIO-R rats. Shifts in the balance between orexigenic and anorexigenic signals within the vagal afferent pathway may influence food intake and body weight gain induced by high fat diets.
Paulino
Gabriel
G
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine, 1321 Haring Hall, Vet Med: APC, University of California, Davis, 1 Shields Ave., Davis, CA 95616, USA.
Barbier de la Serre
Claire
C
Knotts
Trina A
TA
Oort
Pieter J
PJ
Newman
John W
JW
Adams
Sean H
SH
Raybould
Helen E
HE
D000818:Animals; D001069:Appetite Regulation / Q000235:genetics*; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000494:pharmacology; D008297:Male; D009620:Nodose Ganglion / Q000378:metabolism*; D009765:Obesity / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics / Q000378:metabolism; D044102:Receptor, Melanocortin, Type 1 / Q000235:genetics / Q000378:metabolism; D011949:Receptors, Cholecystokinin / Q000235:genetics / Q000378:metabolism; D015854:Up-Regulation / Q000187:drug effects / Q000235:genetics
D004041:Dietary Fats; D043884:Receptor, Cannabinoid, CB1; D044102:Receptor, Melanocortin, Type 1; D011949:Receptors, Cholecystokinin