Neurotoxic effect of occupational exposure to mixed organic solvents in Korea: Posturographic study.
BACKGROUND
This study used static posturography to investigate the neurotoxic effects on workers exposed to mixed organic solvents at low concentrations under the levels of the threshold limit values (TLV).


METHODS
Forty-one workers from four plants exposed to mixed solvents and 90 non-exposed referents were examined. The lifetime cumulative biological exposure (CE) was estimated according to subject's occupational history and biological monitoring results. Static posturography and questionnaire were the basis of data collection.


RESULTS
The mean exposure index of mixed organic solvents of four plants was 0.47 (SD: 0.33, range: 0.08-1.39). The exposed group showed a larger sway area and length under the eye open condition than did the non-exposed group. In a multiple linear regression, a significant positive association was demonstrated between postural sway area and CE.


CONCLUSIONS
This study results suggest that the exposure to organic solvents under TLV levels may cause disturbance in postural stability.
Park
Jae-Beom
JB
Department of Occupational and Environmental Medicine, Ajou University School of Medicine, Woncheon-dong, Yeongtong-gu, Suwon, South Korea.
Lee
Kyung-Jong
KJ
Lee
Keou-Weon
KW
Lim
Kwang-Jin
KJ
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004784:Environmental Monitoring; D005260:Female; D006801:Humans; D007723:Korea; D007902:Length of Stay / Q000706:statistics & numerical data; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009498:Neurotoxins / Q000032:analysis / Q000633:toxicity*; D016273:Occupational Exposure / Q000009:adverse effects* / Q000032:analysis*; D004856:Postural Balance / Q000187:drug effects*; D012997:Solvents / Q000032:analysis* / Q000633:toxicity*; D020711:Threshold Limit Values
D009498:Neurotoxins; D012997:Solvents