JBIR-26, a novel natural compound from Streptomyces sp. AK-AH76, regulates mammalian circadian clock.
In the course of our screening program for regulators of circadian clock system (circadian rhythms), we isolated a new natural compound JBIR-26 (1) from Streptomyces sp. AK-AH76. The structure was determined to be 2-hydroxy-3,6-dimethylbenzoic acid on the basis of spectroscopic data. Compound 1 lengthened the period-length of mammalian clocks for 1.5 hours at a concentration of 10 microg/ml.
Izumikawa
Miho
M
Biomedicinal Information Research Center (BIRC), Japan Biological Informatics Consortium (JBIC), 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Ukai
Hideki
H
Takagi
Motoki
M
Ueda
Hiroki R
HR
Shin-Ya
Kazuo
K
D000818:Animals; D001565:Benzoates / Q000737:chemistry*; D002940:Circadian Rhythm / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D041681:NIH 3T3 Cells; D013302:Streptomyces / Q000737:chemistry*
D001565:Benzoates