title: Scatter Factors in renal disease: Dr. Jeckyll and Mr. Hyde?
abstract: The Scatter Factors are two homologous proteins, named Scatter Factor/Hepatocyte Growth Factor and Macrophage Stimulating Protein. Their receptors are the products of two oncogenes, Met and Ron, respectively. The Scatter Factors induce movement, stimulate proliferation, regulate apoptosis and are morphogenic, i.e. operate an integrated program that seems tailored to drive organ development and to regenerate injured tissues. On the other hand, Scatter Factors may be responsible for pathologic tissue remodeling, infiltration of inflammatory cells, and tumor growth and diffusion. The review describes the involvement of Scatter Factors in renal disease, including acute renal failure, glomerulonephritis, chronic fibrosing nephropathies, dialysis, renal transplantation and renal tumors, and discusses the double-faced role of Scatter Factors, that play either a protective or a pathogenic role.
authors.affiliation: Foundation IRCCS San Matteo Hospital and University of Pavia, Italy.
authors.forename: Teresa
authors.initials: T
authors.lastname: Rampino
authors.forename: Marilena
authors.initials: M
authors.lastname: Gregorini
authors.forename: Antonio
authors.initials: A
authors.lastname: Dal Canton
mesh_terms: D058186:Acute Kidney Injury / Q000235:genetics / Q000378:metabolism; D000818:Animals; D005921:Glomerulonephritis / Q000235:genetics / Q000378:metabolism; D017228:Hepatocyte Growth Factor / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007249:Inflammation; D007668:Kidney / Q000473:pathology; D007674:Kidney Diseases / Q000235:genetics* / Q000378:metabolism; D016030:Kidney Transplantation; D008954:Models, Biological; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D006435:Renal Dialysis
chemical_list: D011518:Proto-Oncogene Proteins; C082332:macrophage stimulating protein; D017228:Hepatocyte Growth Factor