Risk of late-onset hypogonadism (andropause) in Brazilian men over 50 years of age with osteoporosis: usefulness of screening questionnaires.
OBJECTIVE
To analyze the relative risk of late-onset hypogonadism in men with osteoporosis and the usefulness of screening questionnaires.


METHODS
We correlated the Aging Male's Symptoms (AMS), Androgen Deficiency in Aging Male (ADAM) and International Index of Erectile Function (IIEF-5) questionnaires and the laboratory diagnosis of hypogonadism in 216 men aged 50-84 years (110 with osteoporosis and 106 with normal bone density, paired by age and ethnicity).


RESULTS
Hypogonadism presented in 25% of the osteoporotic and in 12.2 % of normal bone density men (OR 2.08; IC95%: 1.14-3.79) and was associated with ADAM first question (low libido, p=0.013). Levels of TT below 400 ng/dl correlated with an AMS score above 26 (p=0.0278). IIEF-5 showed no correlation with testosterone levels.


CONCLUSIONS
Hypogonadism was 2.08 times more prevalent in osteoporotic men. The symptom that best correlated with late-onset hypogonadism was low libido (ADAM 1 positive).
Clapauch
Ruth
R
Division of Female Endocrinology and Andrology, Endocrinology Sector, Hospital da Lagoa, Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, RJ, Brazil.
Braga
Daniel Jorge de Castro
DJ
Marinheiro
Lizanka Paola
LP
Buksman
Salo
S
Schrank
Yolanda
Y
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D047649:Andropause / Q000502:physiology*; D015519:Bone Density / Q000502:physiology; D001938:Brazil / Q000453:epidemiology; D003430:Cross-Sectional Studies; D015577:Geriatric Assessment / Q000379:methods*; D006801:Humans; D007006:Hypogonadism / Q000453:epidemiology*; D007989:Libido / Q000502:physiology; D008297:Male; D008403:Mass Screening; D010024:Osteoporosis / Q000453:epidemiology*; D010410:Penile Erection / Q000502:physiology; D015995:Prevalence; D012306:Risk; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000032:analysis
D013739:Testosterone