title: Covalent modifiers: an orthogonal approach to drug design.
authors.affiliation: Department of Medicinal Chemistry, Amgen Inc., Cambridge, Massachusetts 02139, USA. michelep@amgen.com
authors.forename: Michele H
authors.initials: MH
authors.lastname: Potashman
authors.forename: Mark E
authors.initials: ME
authors.lastname: Duggan
mesh_terms: D001665:Binding Sites; D002219:Carbamates / Q000737:chemistry / Q000494:pharmacology; D016503:Drug Delivery Systems; D015195:Drug Design; D004852:Epoxy Compounds / Q000737:chemistry / Q000494:pharmacology; D004952:Esters / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry / Q000494:pharmacology; D010600:Pharmacology; D011485:Protein Binding; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship
chemical_list: D002219:Carbamates; D004852:Epoxy Compounds; D004952:Esters; D008024:Ligands; D009570:Nitriles; D054852:Small Molecule Libraries