title: Infectious complications in patients with psoriasis and rheumatoid arthritis treated with antitumor necrosis factor agents and methotrexate.
abstract: Treatment of patients with moderate-severe psoriasis and/or psoriatic arthritis includes systemic biologic, antimetabolite, and immunosuppressive therapy. However, adverse events such as serious infectious complications must be considered before starting therapy and throughout treatment. The authors describe the case of a male on combination etanercept and methotrexate for psoriasis and psoriatic arthritis for years who developed a spontaneous epidural abscess with resulting quadriplegia. In addition, a review of the literature was performed looking at the risk of serious infectious complications with antitumor necrosis factor (anti-TNF) monotherapy or combination therapy with methotrexate fro the treatment of psoriasis and rheumatoid arthritis. Serious infectious risk does not appear to be increased with etanercept or other anti-TNF agents either alone or in combination with methotrexate. Nevertheless, clinicians are cautioned to carefully weigh the risks and benefits of treating with anti-TNF agents in patients who are prone to infection.
authors.affiliation: Division of Dermatology, The Ohio State University, Columbus, OH, USA.
authors.forename: Kamruz
authors.initials: K
authors.lastname: Darabi
authors.forename: Rohit
authors.initials: R
authors.lastname: Jaiswal
authors.forename: Sarah
authors.initials: S
authors.lastname: Hostetler
authors.forename: Mark
authors.initials: M
authors.lastname: Bechtel
authors.forename: Matthew
authors.initials: M
authors.lastname: Zirwas
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000276:immunology; D001424:Bacterial Infections / Q000209:etiology* / Q000382:microbiology; D004359:Drug Therapy, Combination; D020802:Epidural Abscess / Q000209:etiology* / Q000382:microbiology; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000276:immunology; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D008875:Middle Aged; D011565:Psoriasis / Q000150:complications* / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000008:administration & dosage / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D000068800:Etanercept; D008727:Methotrexate