title: Less is more for leaderless mRNA translation.
abstract: In this issue of Molecular Cell, Kaberdina et al. (2009) show that prolonged exposure of ribosomes to the antibiotic kasugamycin triggers the spontaneous loss of small subunit proteins and produces a reduced ribosomal particle that exclusively translates leaderless mRNAs.
authors.affiliation: Gene Center, Department for Chemistry and Biochemistry, University of Munich, Munich, Germany. wilson@lmb.uni-muenchen.de
authors.forename: Daniel N
authors.initials: DN
authors.lastname: Wilson
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D008954:Models, Biological; D008958:Models, Molecular; D014176:Protein Biosynthesis / Q000502:physiology*; D011487:Protein Conformation; D012333:RNA, Messenger / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism
chemical_list: D000617:Aminoglycosides; D012333:RNA, Messenger; C100305:kasugamycin