Rethinking T cell immunity in oropharyngeal candidiasis.
The disproportionate increase in oropharyngeal candidiasis (OPC) compared with systemic and vaginal candidiasis in female patients with AIDS has been a paradox for almost three decades. New data now show that severe OPC develops in Th17-deficient mice, but not Th1-deficient mice, implicating Th17-induced effector molecules in resistance to oral disease. These findings clarify and extend our current thinking about how CD4 T cell deficiency influences susceptibility to OPC.
Pirofski
Liise-anne
LA
Department of Medicine, Albert Einstein College of Medicine College of Medicine, Bronx, NY, USA.
Casadevall
Arturo
A
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002180:Candidiasis, Oral / Q000209:etiology* / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology*; D006801:Humans; D051379:Mice