title: A Feedforward-Feedback Glucose Control Strategy for Type 1 Diabetes Mellitus.
abstract: As the "artificial pancreas" becomes closer to reality, automated insulin delivery based on real-time glucose measurements becomes feasible for people with diabetes. This paper is concerned with the development of novel feedforward-feedback control strategies for real-time glucose control and type 1 diabetes. Improved post-meal responses can be achieved by a pre-prandial snack or bolus, or by reducing the glucose setpoint prior to the meal. Several feedforward-feedback control strategies provide attractive alternatives to the standard meal insulin bolus and are evaluated in simulations using a physiological model.
authors.affiliation: DIPIC-Department of Chemical Engineering Principles and Practice, Università di Padova, via Marzolo 9, 35131 Padova (Italy).
authors.forename: Gianni
authors.initials: G
authors.lastname: Marchetti
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Barolo
authors.forename: Lois
authors.initials: L
authors.lastname: Jovanovič
authors.forename: Howard
authors.initials: H
authors.lastname: Zisser
authors.forename: Dale E
authors.initials: DE
authors.lastname: Seborg