title: Large-cell neuroendocrine carcinoma of the uterine cervix complicating pregnancy.
abstract: Large-cell neuroendocrine cervical carcinoma is a rare and aggressive cancer that tends to spread and recur early despite intensive multimodal treatment. The optimal mode of therapy is still controversial and management during pregnancy is challenging because foetal well-being must also be considered. We report a patient with clinically stage IIB large-cell neuroendocrine cervical carcinoma who presented with a cervical polyp and vaginal bleeding at 18 weeks of pregnancy. The patient received concurrent chemotherapy and radiation after termination of pregnancy and remained in complete remission 21 months after completion of treatment.
authors.affiliation: Department of Obstetrics and Gynaecology, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong. liwh2@yahoo.com.hk
authors.forename: William W H
authors.initials: WW
authors.lastname: Li
authors.forename: T N
authors.initials: TN
authors.lastname: Yau
authors.forename: Carmen W L
authors.initials: CW
authors.lastname: Leung
authors.forename: W M
authors.initials: WM
authors.lastname: Pong
authors.forename: May Y M
authors.initials: MY
authors.lastname: Chan
mesh_terms: D000028:Abortion, Induced; D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D018287:Carcinoma, Large Cell / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D018278:Carcinoma, Neuroendocrine / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D002584:Cervix Uteri / Q000473:pathology; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D011127:Polyps / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide