The use of boluses of propofol for the management of severe tetanus in a child.
Tetanus is endemic in many developing countries. Although propofol has been proposed for sedation in tetanus, the routine use of this drug has not been clearly documented in published reports. A few studies have reported its beneficial effects but no randomized studies are available. We describe the case of a five-year-old boy who presented with severe tetanus in East Africa. The antispastic therapy consisted of benzodiazepine infusion with the addition of titrated boluses of propofol. Intubation and mechanical ventilation were avoided.
Petitjeans
Fabrice
F
Department of Anesthesiology and Intensive Care, Desgenettes Military Hospital, 108 bd Pinel, 69003 Lyon, France. fabricepetitjeans@yahoo.fr
Turc
Jean
J
Coulet
Olivier
O
Puidupin
Marc
M
Eve
Olivier
O
Benois
Alain
A
D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use; D001569:Benzodiazepines / Q000008:administration & dosage / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000627:therapeutic use; D012720:Severity of Illness Index; D013035:Spasm / Q000517:prevention & control; D013742:Tetanus / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome
D018686:Anesthetics, Intravenous; D000927:Anticonvulsants; D001569:Benzodiazepines; D015742:Propofol