Recurrent bullous lesions associated with familial Mediterranean fever: a case report.
Familial Mediterranean fever (FMF) is an inherited, recurrent, inflammatory disease. Of its various cutaneous features, erysipelas-like erythema is the best known and most common skin lesion. We present a new case of FMF with recurrent bullous lesions. A 41-year-old woman was admitted to our clinic with tense bullae, 20 x 20 mm in diameter on the left shin. The patient had a history of fever, abdominal pain, peritonitis attacks and infertility. A lesional skin biopsy revealed subepidermal bullae and neutrophilic infiltration around dermal vessels. Direct immunofluorescence analysis was negative. Over the period of investigation, the lesion regressed spontaneously; 1 month later, a similar lesion appeared on the right wrist. Diagnosis of FMF was made according to the Tel-Hashomer criteria. Recognition of this peculiar skin lesion may lead to an earlier diagnosis of the disease.
Akman
A
A
Departments of Dermatology and Venerology, School of Medicine, Antalya, Turkey. aakman@akdeniz.edu.tr
Cakcak
D S
DS
Coban
E
E
Ozbudak
H I
HI
Ciftcioglu
M A
MA
Alpsoy
E
E
Yilmaz
E
E
D015746:Abdominal Pain / Q000150:complications; D000328:Adult; D001768:Blister / Q000150:complications / Q000473:pathology*; D003078:Colchicine / Q000627:therapeutic use; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006074:Gout Suppressants / Q000627:therapeutic use; D006801:Humans; D012008:Recurrence; D016896:Treatment Outcome
D006074:Gout Suppressants; D003078:Colchicine