title: Heparin-coated stents do not protect cancer patients from cardiac complications after noncardiac surgery.
abstract: Previous studies regarding preoperative coronary stents and antithrombotic agents have excluded patients with cancer as a result of hypercoagulability. The objective of this study is to determine whether preoperative heparin-coated coronary stents are as safe in patients with cancer undergoing surgery as patients without cancer. Between February 2003 and February 2005, 29 patients had heparin-coated coronary stents placed before noncardiac surgery. The incidence of postoperative myocardial infarction (MI) and/or death was compared in patients with and without cancer, and outcomes were further evaluated based on preoperative antithrombotic status. Postoperative MI occurred in three of 13 (23%) patients with cancer compared with zero of 16 noncancer patients. Patients with cancer were 9.6 times more likely to have a postoperative MI resulting in death compared with noncancer patients. There was a positive correlation between patients having cancer and having a postoperative MI (r = 0.38, P = 0.044) and between patients with cancer being on antithrombotic medications during surgery and having a postoperative MI (r = 0.567, P = 0.044). After stent placement, patients with cancer undergoing surgery experienced a higher incidence of postoperative MI resulting in death compared with noncancer patients despite continued antithrombotic use. In these patients, alternatives to stenting should be considered to avoid perioperative cardiac complications.
authors.affiliation: Department of Surgery, Loyola University Medical Center, Maywood, Illinois 60153, USA.
authors.forename: Karen L
authors.initials: KL
authors.lastname: Sherman
authors.forename: Shawn H
authors.initials: SH
authors.lastname: Obi
authors.forename: Gerard V
authors.initials: GV
authors.lastname: Aranha
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Yao
authors.forename: Margo C
authors.initials: MC
authors.lastname: Shoup
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000008:administration & dosage*; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000150:complications / Q000473:pathology / Q000628:therapy; D054855:Drug-Eluting Stents; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D009369:Neoplasms / Q000150:complications / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies
chemical_list: D000925:Anticoagulants; D005343:Fibrinolytic Agents; D006493:Heparin