Velleratretraol, an unusual highly functionalized lactarane sesquiterpene from Lactarius vellereus.
An unusual highly functionalized lactarane sesquiterpene, named velleratretraol (1), was isolated from the ethanol extract of the fruiting body of the mushroom Lactarius vellereus. Its structure was determined through spectroscopic analysis and single-crystal X-ray diffraction studies. The proposed assignment of the absolute configuration is based on computational results. It showed weak activity against HIV-1 cells with an effective concentration of 68.0 microg ml(-1) and a selectivity index of 2.0.
Luo
Du-Qiang
DQ
College of Life Science, Key Laboratory of Pharmaceutical Chemistry and Molecular Diagnosis, Ministry of Education and Research Center of Biotechnology of Hebei Province, Hebei University, Baoding, China. duqiangluo@163.com
Zhao
Li-Yan
LY
Shi
Yao-Long
YL
Tang
Hong-Liang
HL
Li
Yu-Ye
YY
Yang
Liu-Meng
LM
Zheng
Yong-Tang
YT
Zhu
Hua-Jie
HJ
Liu
Ji-Kai
JK
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism; D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006678:HIV / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
D019380:Anti-HIV Agents; D007202:Indicators and Reagents; D007783:Lactones; D012717:Sesquiterpenes; C544241:velleratretraol