A regioselective Ru-catalyzed alkene-alkyne coupling to form (Z,Z)-1,3-dienes.
Generally, Ru-catalyzed alkene-alkyne coupling forms 1,4-dienes. A version of this process which generates a 1,3-diene as the Z,Z-isomer preferentially has now been observed. The scope of this new atom-economic process is described herein.
Trost
Barry M
BM
Department of Chemistry, Stanford University, Stanford, California 94305-5080, USA. bmtrost@leland.stanford.edu
Martos-Redruejo
Alicia
A