title: Fatal Epstein-Barr virus primo infection in a 25-year-old man treated with azathioprine for Crohn's disease.
abstract: We report a case of Epstein-Barr virus (EBV) primo infection with the development of successive infectious mononucleosis, hemophagocytic lymphohistiocytosis, and B-cell lymphoproliferative disorder in a patient treated with azathioprine for Crohn's disease. This case report suggests that specific EBV-related clinical and virological management should be considered when treating a patient with inflammatory bowel disease with azathioprine.
authors.affiliation: Service de Médicine Interne et des Maladies Infectieuses, Hôpital Robert Debré-CHU Reims, Reims, France.
authors.forename: Y
authors.initials: Y
authors.lastname: N'guyen
authors.forename: L
authors.initials: L
authors.lastname: Andreoletti
authors.forename: M
authors.initials: M
authors.lastname: Patey
authors.forename: C
authors.initials: C
authors.lastname: Lecoq-Lafon
authors.forename: P
authors.initials: P
authors.lastname: Cornillet
authors.forename: A
authors.initials: A
authors.lastname: Léon
authors.forename: R
authors.initials: R
authors.lastname: Jaussaud
authors.forename: C
authors.initials: C
authors.lastname: Fieschi
authors.forename: C
authors.initials: C
authors.lastname: Strady
mesh_terms: D000328:Adult; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
chemical_list: D007166:Immunosuppressive Agents; D001379:Azathioprine