Synthesis and biological activity of anticoccidial agents: 2,3-diarylindoles.
Novel 2,3-diarylindoles bearing an amine substituent at the indole 5- and 6-positions have been synthesized and evaluated as anticoccidial agents in both in vitro and in vivo assays. Both subnanomolar in vitro activity and broad spectrum in vivo potency were detected for several compounds, particularly compound 27.
Scribner
Andrew
A
SCYNEXIS, Inc., Discovery Chemistry, PO Box 12878, Research Triangle Park, NC 27709-2878, USA.
Moore
Joseph A
JA
Ouvry
Gilles
G
Fisher
Michael
M
Wyvratt
Matthew
M
Leavitt
Penny
P
Liberator
Paul
P
Gurnett
Anne
A
Brown
Chris
C
Mathew
John
J
Thompson
Donald
D
Schmatz
Dennis
D
Biftu
Tesfaye
T
D000818:Animals; D003048:Coccidiosis / Q000188:drug therapy / Q000201:enzymology / Q000469:parasitology; D003049:Coccidiostats / Q000138:chemical synthesis* / Q000494:pharmacology; D017869:Cyclic GMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D016786:Eimeria tenella / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011200:Poultry / Q000469:parasitology; D011725:Pyridines / Q000138:chemical synthesis
D003049:Coccidiostats; D007211:Indoles; D011725:Pyridines; D017869:Cyclic GMP-Dependent Protein Kinases; C023666:pyridine