title: The influence of chronic periodontitis on serum TNF-alpha, IL-6 and hs-CRP concentrations, and function of graft and survival of kidney transplant recipients.
abstract: OBJECTIVE
  The aim of the study is to analyze whether chronic periodontitis (CP) influences serum tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, and high-sensitivity C-reactive protein (hs-CRP) concentrations in renal transplant recipients and patients or graft survival.
  
  
  BACKGROUND
  CP is associated both with higher serum concentrations of cytokines and CRP and high cardiovascular risk.
  
  
  METHODS
  One hundred and seventeen patients with a transplanted kidney (Tx) were divided according to the Community Periodontal Index of Treatment Needs (CPITN) into two subgroups: TxP+: severe CP (CPITN 3-4) and TxP-: no or moderate CP (CPITN 0-2). The control group (C) consisted of 36 subjects with no kidney disease and with no or moderate CP (CPITN 0-2).
  
  
  RESULTS
  hs-CRP concentration was higher in TxP+ than in TxP- patients [2.0 mg/L (0.7-4.4) vs. 0.9 mg/L (0.3-1.9), p = 0.006]. There were no differences in serum TNF-alpha and IL-6 between TxP+ and TxP-. Significant positive correlation between CPITN score and hs-CRP concentration was found both in Tx and C. The hazard ratio of death was 7.17 (1.4-76.4) for TxP+ patients. CP status did not increase the risk of graft loss or doubling of serum creatinine.
  
  
  CONCLUSIONS
  Severe CP is associated with increased serum hs-CRP concentration in patients after kidney transplantation. Severe periodontitis seems to increase the risk of patients' death after kidney transplantation.
authors.affiliation: Department of Internal Diseases and Rheumatology, Silesian University School of Medicine, Katowice, Poland.
authors.forename: Anna
authors.initials: A
authors.lastname: Blach
authors.forename: Edward
authors.initials: E
authors.lastname: Franek
authors.forename: Artur
authors.initials: A
authors.lastname: Witula
authors.forename: Aureliusz
authors.initials: A
authors.lastname: Kolonko
authors.forename: Jerzy
authors.initials: J
authors.lastname: Chudek
authors.forename: Jan
authors.initials: J
authors.lastname: Drugacz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wiecek
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism*; D055113:Chronic Periodontitis / Q000097:blood* / Q000628:therapy; D005260:Female; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein