A follow-up study of chromosome 19q13 in multiple sclerosis susceptibility.
A possible role of allelic variation on chromosome 19q13 in multiple sclerosis (MS) susceptibility has been suggested. We tested association of sixteen 19q13 markers with MS in 459 families. Nominally significant associations were tested in an independent set of 323 families as well as in the pooled set of 782 families. We were not able to confirm previously suggested associations with APOE, GIPR, ZNF45, ILT6 and D19S585. In the screening dataset nominally significant associations were found with D19S867 and with APOE haplotype (p=0.007 in both), but these were not replicated in the independent dataset nor in the pooled analysis of 757 families. Thus, we were not able to detect any statistically significant allelic associations. Re-sequencing based approaches may be required for elucidating the role chromosome 19q13 with MS.
Bonetti
Alessandro
A
Molecular Neuroscience Programme, Biomedicum-Helsinki, University of Helsinki, Helsinki University Central Hospital, Helsinki, Finland. alessandro.bonetti@helsinki.fi
Koivisto
Keijo
K
Pirttilä
Tuula
T
Elovaara
Irina
I
Reunanen
Mauri
M
Laaksonen
Mikko
M
Ruutiainen
Juhani
J
Peltonen
Leena
L
Rantamäki
Terhi
T
Tienari
Pentti J
PJ
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005787:Gene Frequency / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*
D005819:Genetic Markers