Pattern-based recognition of heparin contaminants by an array of self-assembling fluorescent receptors.
Tracking down potential killers: Strong host-guest interactions enable the facile combination of polycationic cyclodextrin binding motifs (blue) with fluorescent reporters (orange) tethered to a hydrophobic guest molecule (dark green). An array of supramolecular fluorescent receptors prepared by this modular approach was used for the pattern-based recognition of negatively charged contaminants in the anticoagulant drug heparin.
Jagt
Richard B C
RB
Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON, M5S 3H6, Canada.
Gómez-Biagi
Rodolfo F
RF
Nitz
Mark
M
D000925:Anticoagulants / Q000737:chemistry*; D003505:Cyclodextrins / Q000737:chemistry*; D004340:Drug Contamination / Q000517:prevention & control; D005456:Fluorescent Dyes / Q000737:chemistry*; D006493:Heparin / Q000737:chemistry*; D008968:Molecular Conformation; D011108:Polymers / Q000737:chemistry
D000925:Anticoagulants; D003505:Cyclodextrins; D005456:Fluorescent Dyes; D011108:Polymers; D006493:Heparin