Effects of cardiac resynchronization therapy on the Doppler Tei index.
BACKGROUND
The Tei index is an indicator of systolic and diastolic myocardial performance. We evaluated the Tei index in patients undergoing cardiac resynchronization therapy (CRT).


METHODS
Forty-two patients were studied before CRT and 1 day and 6 months after CRT, comparing responders with nonresponders.


RESULTS
The Tei index decreased 1 day after CRT (left ventricle [LV]: P < .001, right ventricle [RV]: P = .01) and remained lower at follow-up (LV and RV: P < .001 vs baseline). Responders had a higher LV Tei index at baseline (P = .003) and achieved a sustained improvement in Tei index at follow-up (LV: P < .001, RV: P = .002) in contrast with nonresponders (LV and RV: not significant). Baseline LV Tei index and change in LV Tei index were both correlated with LV end-systolic volume reduction after CRT (r = 0.52, P < .001, r = 0.43, P = .006).


CONCLUSIONS
The baseline LV Tei index was significantly higher in responders and exhibited an acute and sustained improvement after CRT. The baseline RV Tei index was similar in responders and nonresponders but improved significantly only in responders.
Yuasa
Toshinori
T
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Miyazaki
Chinami
C
Oh
Jae K
JK
Espinosa
Raul E
RE
Bruce
Charles J
CJ
D000368:Aged; D002304:Cardiac Pacing, Artificial / Q000379:methods*; D015150:Echocardiography, Doppler / Q000379:methods* / Q000592:standards; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging* / Q000517:prevention & control*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D011379:Prognosis; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000517:prevention & control*