[The effect of prolonged repeated immobilisation on metabolism of biogenic amins in the lungs of rats with different prognostic resistance against emotional stress].
In chronic experiment on male albino rats divided into active and passive groups according to their behavior in "open field" test significant differences in character of lung metabolic activity upon biogenic amines were found out. In both groups the highest level of histamine in arterial and venous blood was registered on the 5th day, 5-hydroxytriptamine--on the 10-20 days and catecholamine--on the 20th day of the experiment. On the 5th day lungs pf passive rats uptaked catecholamines from blood whereas lungs of active ones put in into blood. Histamine and 5-hydroxytriptamine uptake took place on the 5th day only in active rats, but on the 10th only lungs of passive ones absorbed 5-hydroxytriptamine from blood. Intergroup differences of lung metabolic activity upon histamine and 5-hydroxytriptamine were removed on the 20th day. Lung monoamine oxydase activity was significantly increased in active rats and decreased in passive ones in all periods of experiment.
Sorokin
A V
AV
Bryndina
I G
IG
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D007103:Immobilization; D008168:Lung / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D013997:Time Factors
D001679:Biogenic Amines; D008995:Monoamine Oxidase