Chikungunya virus and central nervous system infections in children, India.
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus best known for causing fever, rash, arthralgia, and occasional neurologic disease. By using real-time reverse transcription-PCR, we detected CHIKV in plasma samples of 8 (14%) of 58 children with suspected central nervous system infection in Bellary, India. CHIKV was also detected in the cerebrospinal fluid of 3 children.
Lewthwaite
Penny
P
University of Liverpool, Liverpool, UK. pennylewthwaite@doctors.org.uk
Vasanthapuram
Ravi
R
Osborne
Jane C
JC
Begum
Ashia
A
Plank
Jenna L M
JL
Shankar
M Veera
MV
Hewson
Roger
R
Desai
Anita
A
Beeching
Nick J
NJ
Ravikumar
Ravi
R
Solomon
Tom
T
D000293:Adolescent; D018354:Alphavirus Infections / Q000097:blood / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000821:virology; D020805:Central Nervous System Viral Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000453:epidemiology / Q000821:virology; D002555:Cerebrospinal Fluid / Q000821:virology; D002646:Chikungunya virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D002648:Child; D002675:Child, Preschool; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA