title: [A case of kappa L-chain primary nodular lung amyloidosis].
abstract: Amyloidosis is a generic term for a heterogeneous group of disorders associated with deposition of protein in an abnormal fibrillar form. We report a case of kappa L-chain primary lung amyloidosis. A 44-year-old woman without symptoms. Roentgenogram and computed tomography of the chest showed several small nodular shadows. The mammography revealed tumor of the breast and the metastatic breast cancer have been suspected. After the quadrantectomy the breast tumor has been diagnosed as adenoma. The diagnosis of pulmonary amyloidosis was established by an open lung biopsy. Immunohistochemistry revealed amyloid light (AL) of kappa-light chain origin. Serum protein electrophoresis was negative for monoclonal gammapathy. Over the next 6 years, the patient remained relatively asymptomatic. The case illustrates the problems with diagnosis of multiple solitary nodules and the long and relatively benign course of primary pulmonary amyloidosis.
authors.affiliation: Akademia Medyczna we Wrocławiu, Katedra i Klinika Pulmonologii i Nowotworbw Płuc. mika113@tlen.pl
authors.forename: Monika
authors.initials: M
authors.lastname: Kosacka
authors.forename: Renata
authors.initials: R
authors.lastname: Wojtala
authors.forename: Paweł
authors.initials: P
authors.lastname: Piesiak
authors.forename: Ewa
authors.initials: E
authors.lastname: Passowicz-Muszyńska
authors.forename: Renata
authors.initials: R
authors.lastname: Jankowska
mesh_terms: D000328:Adult; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000175:diagnosis* / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D008175:Lung Neoplasms / Q000175:diagnosis; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology
chemical_list: D000682:Amyloid; D015415:Biomarkers; D007145:Immunoglobulin kappa-Chains