Singly hydrogen bonded supramolecular ligands for highly selective rhodium-catalyzed hydrogenation reactions.
H bonds make the catalysts! A single hydrogen bond between ligands coordinated to a rhodium center is critical for the formation of pure supramolecular catalysts for asymmetric hydrogenation reactions. The ester group of the amidite ligand (see scheme) also forms a hydrogen bond with the coordinated substrate. Use of the heterocomplex afforded the highest enantioselectivity reported to date for the hydrogenation of several ester substrates.
Breuil
Pierre-Alain R
PA
Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166 1018 WV, Amsterdam, The Netherlands.
Patureau
Frederic W
FW
Reek
Joost N H
JN