[Metabolic syndrome].
Metabolic syndrome, which is consisted of hypertension, dyslipidemia and impaired glucose tolerance, is one of the most significant lifestyle-related disorders that lead to cardiovascular diseases. Among many upstream factors that are related to metabolic syndrome, obesity, especially visceral obesity, plays an essential role in its pathogenesis. In recent studies, possible mechanisms which connect obesity to metabolic syndrome have been elucidated, such as inflammation, abnormal secretion of adipokines and mitochondrial dysfunction. In this review, we focus on the relationship between obesity and metabolic syndrome; and illustrate how visceral obesity contributes to, and how the treatments for obesity act on metabolic syndrome.
Mitsuishi
Masanori
M
Department of Internal Medicine, School of Medicine, Keio University.
Miyashita
Kazutoshi
K
Itoh
Hiroshi
H
D006801:Humans; D050152:Intra-Abdominal Fat; D024821:Metabolic Syndrome / Q000209:etiology*; D009765:Obesity / Q000150:complications / Q000628:therapy