Temsirolimus-induced glomerulopathy.
A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion. Kidney biopsy revealed ischemic glomeruli and focal segmental glomerulosclerosis lesion. Proteinuria level decreased to 2.80 g per day two weeks after temsirolimus withdrawal. Clinicians should be aware to this complication.
Izzedine
Hassane
H
Department of Nephrology, Pitié-Salpêtrière Hospital, Paris, France. hassan.izzedine@psl.ap-hop-paris.fr
Boostandoot
Erfaneh
E
Spano
Jean Philippe
JP
Bardier
Armelle
A
Khayat
David
D
D000970:Antineoplastic Agents / Q000009:adverse effects*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000139:chemically induced; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives*
D000970:Antineoplastic Agents; C401859:temsirolimus; D020123:Sirolimus