title: [Oncogenic osteomalacia: localization of underlying peripheral tumor with 99mTc-sestamibi scintigraphy].
abstract: Oncogenic osteomalacia is a paraneoplastic syndrome usually induced by bone or soft tissue tumors. It is presented by the development of pain and fractures with hypophosphatemia, hyperphosphaturia, and inappropriate normal/low plasma 1,25(OH)2D3 concentration. After the removal of the tumor the complete resolution of all biochemical and clinical abnormalities is the main characteristic. A case of a 44-year-old female with difficulty in walking due to leg pain and generalized muscle weakness and hypophosphatemia, with relative hyperphosphaturia, is described. A whole-body 99mTc-sestamibi scintigraphy showed accumulation in the left thigh region, and a small tumor was detected by ultrasound examination. By removal of the tumor, a lipoma, the symptoms improved significantly after a month, with complete recovery by the fourth month. In this case, 99mTc-sestamibi scintigraphy was useful in identifying the location of the tumor, which caused oncogenic osteomalacia.
authors.affiliation: Faculdade Evangélica do Paraná, Curitiba, PR, Brazil.
authors.forename: Gleyne Lopes Kujew
authors.initials: GL
authors.lastname: Biagini
authors.forename: Priscilla Rizental
authors.initials: PR
authors.lastname: Coutinho
authors.forename: Thaisa Hoffman
authors.initials: TH
authors.lastname: Jonasson
authors.forename: Cristina Emiko
authors.initials: CE
authors.lastname: Ueda
authors.forename: Ricardo Ribeiro
authors.initials: RR
authors.lastname: Gama
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D017674:Hypophosphatemia / Q000473:pathology; D008648:Mesoderm / Q000473:pathology; D010018:Osteomalacia / Q000000981:diagnostic imaging*; D010524:Peripheral Nervous System Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi