Different regulation modes of calcineurin regulatory subunit on its catalytic subunit with RII peptide and tau as substrates.
Calcineurin (CN) is a heterodimer of a catalytic subunit, calcineurin A (CNA), and a regulatory subunit (CNB). Here, we find that the mechanism by which CNB regulates CNA depends on the substrate involved. The regulation mechanism involving tau and its truncation segments is distinct from that involving RII peptide, and the efficiencies of CNA to dephosphorylate tau are constant regardless of whether CNB was present or not. The findings shed some light on the role of CNB in controlling phosphorylation of tau in vivo and the pathogenesis of tauopathies such as Alzheimer's Disease.
Yu
Da-yu
DY
Department of Applied Chemistry and Biological Engineering, Northeast Dianli University, Jilin 132012, China. yudy@mail.nedu.edu.cn
Qiao
Nan
N
Liu
Ping
P
Wei
Qun
Q
D000544:Alzheimer Disease; D000704:Analysis of Variance; D000818:Animals; D019703:Calcineurin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D010455:Peptides / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats; D016875:tau Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D010455:Peptides; D016875:tau Proteins; D019703:Calcineurin