Gene X environment interactions in reading disability and attention-deficit/hyperactivity disorder.
This article examines Gene x Environment (G x E) interactions in two comorbid developmental disorders--reading disability (RD) and attention-deficit/hyperactivity disorder (ADHD)--as a window on broader issues on G x E interactions in developmental psychology. The authors first briefly review types of G x E interactions, methods for detecting them, and challenges researchers confront in interpreting such interactions. They then review previous evidence for G x E interactions in RD and ADHD, the directions of which are opposite to each other: bioecological for RD and diathesis stress for ADHD. Given these results, the authors formulate and test predictions about G x E interactions that would be expected at the favorable end of each symptom dimension (e.g., above-average reading or attention). Consistent with their prediction, the authors found initial evidence for a resilience interaction for above-average reading: higher heritability in the presence of lower parental education. However, they did not find a G x E interaction at the favorable end of the ADHD symptom dimension. The authors conclude with implications for future research.
Pennington
Bruce F
BF
Department of Psychology, University of Denver, USA. bpenning@du.edu
McGrath
Lauren M
LM
Rosenberg
Jenni
J
Barnard
Holly
H
Smith
Shelley D
SD
Willcutt
Erik G
EG
Friend
Angela
A
Defries
John C
JC
Olson
Richard K
RK
D000818:Animals; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D004410:Dyslexia / Q000175:diagnosis / Q000209:etiology / Q000235:genetics; D004777:Environment; D005796:Genes / Q000502:physiology*; D005838:Genotype; D006801:Humans; D008954:Models, Biological; D010700:Phonetics