title: Energy restriction for breast cancer prevention.
abstract: Weight gain in adult life is an important risk factor for breast cancer. Observational studies indicate that pre- or postmeno-pausal weight loss is associated with a reduction in risk of postmenopausal breast cancer. Here we summarise lifestyle changes including continuous or intermittent energy restriction and/or exercise which may be beneficial for preventing breast cancer and also potential pharmacological approaches to prevention using energy restriction mimetic agents (ERMAs).
authors.affiliation: Christie Hospital NHS Trust, University of Manchester, CRUK Department of Medical Oncology, UK. maria.parker@christie-tr.nwest.nhs.uk
authors.forename: Anthony
authors.initials: A
authors.lastname: Howell
authors.forename: Mary
authors.initials: M
authors.lastname: Chapman
authors.forename: Michelle
authors.initials: M
authors.lastname: Harvie
mesh_terms: D001943:Breast Neoplasms / Q000378:metabolism / Q000517:prevention & control*; D031204:Caloric Restriction; D004734:Energy Metabolism / Q000502:physiology*; D005081:Exercise Therapy; D005260:Female; D006801:Humans