Hypocapnia induced by involuntary hyperventilation during mental arithmetic reduces cerebral blood flow velocity.
Functional neuroimaging studies have shown that cognitive processes increase regional cerebral blood flow in relation with enhanced neuronal activity. However, cognition induces elevation of blood pressure, heart rate and respiratory rate, each of which also affects cerebral circulation. For proper interpretation of functional neuroimaging data, it is necessary to dissociate the effects of systemic and local metabolic reactions on regional cerebral circulation. To elucidate this interaction, we examined the changes in cerebral blood flow velocity, which were caused by voluntary hyperventilation-induced hypocapnia without cognitive effort and hypocapnia evolving during mental arithmetic task. The cerebral blood flow velocity was recorded in the middle cerebral arteries, using transcranial Doppler sonography. Respiratory rate, end-tidal partial pressure of CO(2), heart rate and arterial blood pressure were simultaneously monitored. Data were statistically evaluated. Hypocapnia induced by voluntary hyperventilation without cognition decreased the cerebral blood flow velocity. During mental arithmetic, the cerebral blood flow velocity first increased, but the hypocapnia, which was induced by involuntary hyperventilation related to cognitive effort, reduced it. This implies temporary vasoconstriction of cerebral microvessels, and the increase in cerebral vascular resistance index supports this finding. These results suggest that hypocapnia, which develops during cognition, may decrease blood flow velocity in the middle cerebral arteries, which interferes with the neuronal activity-driven regulation of cerebral circulation. In conclusion, when interpreting the results of functional neuroimaging studies on cognitive mechanisms, the tight coupling of the effects of mental processes and autonomic/metabolic reactions should be considered.
Debreczeni
Róbert
R
Department of Neurology, Faculty of Medicine, Semmelweis University, Balassa u.6, Budapest, Hungary.
Amrein
Ilona
I
Kamondi
Anita
A
Szirmai
Imre
I
D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology; D002245:Carbon Dioxide; D002560:Cerebrovascular Circulation; D003071:Cognition / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006985:Hyperventilation / Q000150:complications* / Q000503:physiopathology*; D016857:Hypocapnia / Q000209:etiology* / Q000503:physiopathology*; D008297:Male; D008433:Mathematics; D013990:Tidal Volume; D014655:Vascular Resistance / Q000502:physiology
D002245:Carbon Dioxide