Effects of gonadotrophin-releasing hormone outside the hypothalamic-pituitary-reproductive axis.
Gonadotrophin-releasing hormone (GnRH) is a hypothalamic decapeptide with an undisputed role as a primary regulator of gonadal function. It exerts this regulation by controlling the release of gonadotrophins. However, it is becoming apparent that GnRH may have a variety of other vital roles in normal physiology. A reconsideration of the potential widespread action that this traditional reproductive hormone exerts may lead to the generation of novel therapies and provide insight into seemingly incongruent outcomes from current treatments using GnRH analogues to combat diseases such as prostate cancer.
Skinner
D C
DC
Neurobiology Program and Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071, USA. dcs@uwyo.edu
Albertson
A J
AJ
Navratil
A
A
Smith
A
A
Mignot
M
M
Talbott
H
H
Scanlan-Blake
N
N
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D052681:Gonadotrophs / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism* / Q000627:therapeutic use*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010902:Pituitary Gland / Q000378:metabolism*; D010913:Pituitary-Adrenal System / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism
D007987:Gonadotropin-Releasing Hormone