The astrocytic response in early experimental autoimmune encephalomyelitis occurs across both the grey and white matter compartments.
An unexpectedly prominent aspect of murine experimental autoimmune encephalomyelitis is pre-onset astrocyte reactivity. Further examination of this phenomenon in the spinal cord demonstrates that grey matter, as well as white matter astrocytes, change their morphology and cell density from the earliest disease manifestation. Comparison of the two compartments reveals that, whereas white matter changes are rostro-caudally consistent, grey matter reactivity is spatially restricted and of varying amplitude between spinal cord levels. These data strongly suggest that in neuroinflammation early, cross-compartmental recruitment of astrocytes occurs, but with different expression patterns.
Pham
Hong
H
Department of Biochemistry, La Trobe University, Bundoora 3086, Victoria, Australia.
Ramp
Anton A
AA
Klonis
Nectarios
N
Ng
Sze Woei
SW
Klopstein
Armelle
A
Ayers
Margaret M
MM
Orian
Jacqueline M
JM
D000818:Animals; D001253:Astrocytes / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*; D001923:Brain Chemistry / Q000276:immunology; D002417:Cattle; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein; D006801:Humans; D006984:Hypertrophy; D051379:Mice; D016688:Mice, Inbred NOD; D009413:Nerve Fibers, Myelinated / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000276:immunology; D013116:Spinal Cord / Q000737:chemistry / Q000166:cytology / Q000276:immunology / Q000473:pathology; D013552:Swine; D013997:Time Factors
D005904:Glial Fibrillary Acidic Protein; D009419:Nerve Tissue Proteins; C528900:glial fibrillary astrocytic protein, mouse