Correlation between pulse wave velocity and fluid distribution in hemodialysis patients.
BACKGROUND
In this study, we focused on whether volume overload plays a role in the development of arterial stiffness.


METHODS
Seventy-three prevalent hemodialysis patients were enrolled in a cross-sectional study. Arterial stiffness was assessed by carotid-femoral pulse wave velocity (PWV), and volume overload was assessed by bioimpedance analysis.


RESULTS
Patients were divided into a high PWV group and a low PWV group based on the median of PWV. Age, systolic blood pressure, pulse pressure (PP), extracellular water/total body water ratio (ECW/TBW), diabetic status (all p < 0.01), and history of cardiac events (p < 0.05) were significantly higher in the high PWV group (n = 37) than in the low PWV group. In the correlation analysis, PWV was positively associated with PP, systolic blood pressure, ECW/TBW, age, history of cardiac events, and diabetes (all p < 0.01). Multiple regression analysis showed that PWV was independently related to PP and ECW/TBW (p < 0.01).


CONCLUSIONS
Volume overload plays an important role in the development of arterial stiffness in hemodialysis patients.
Zheng
Danxia
D
Division of Nephrology, Peking University Third Hospital, Beijing, PR China. dxzheng@sina.com
Cheng
Li-Tao
LT
Zhuang
Zhen
Z
Gu
Yue
Y
Tang
Li-Jun
LJ
Wang
Tao
T
D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D003430:Cross-Sectional Studies; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014655:Vascular Resistance