[Evaluation of the mutagenic properties of nanomaterials].
Nanomaterials have properties showing their possible mutagenic activity. The review analyzes the currently available studies evaluating the mutagenic properties of nanomaterials. The studies have been conducted using limited quantities of nanomaterials and mainly in in vitro experiments. But they also suggest that nanomaterials are able to induce DNA damages, chromosomal aberrations, micronuclei, and aneuploidy. Single studies have revealed consequences due to the genotoxic effect of nanomaterials: rat lung cancer. There is a need for developing a system to evaluate the mutagenic properties of nanomaterials, the basis of which may be a polyorgan micronuclear test, by taking the indicators of proliferation and apoptosis into account.
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D037741:Fullerenes; D006801:Humans; D016296:Mutagenesis / Q000235:genetics*; D009152:Mutagenicity Tests; D049329:Nanostructures; D036103:Nanotechnology
D037741:Fullerenes