title: Estrogen receptor beta gene +1730 G/A polymorphism in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate whether the +1730 G/A polymorphism in the estrogen receptor (ER)-beta gene is associated with susceptibility to polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University Department of Obstetrics and Gynecology.
  
  
  METHODS
  Women with (n = 138) or without (n = 290) PCOS.
  
  
  METHODS
  Genotyping was performed by polymerase chain reaction-restriction fragment-length polymorphism analysis.
  
  
  METHODS
  Genotype distribution and allele frequency of the +1730 G/A polymorphism in the ER-beta gene.
  
  
  RESULTS
  There was a significant difference in the genotype distribution between the patients with PCOS and controls (non-GG rates were 22.1% for patients with PCOS and 36.6% for controls). There was also a significant difference in the G and A allele frequencies between these two groups (11.7% in patients vs. 19.1% in controls with A allele). But in patients with PCOS there were no significant differences in the serum levels of hormones, biochemical variables, or ovarian morphology between GG and non-GG genotypes.
  
  
  CONCLUSIONS
  The ER-beta gene +1730 G/A polymorphism may be associated with pathophysiologic aberrancies involved in PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Seon Ha
authors.initials: SH
authors.lastname: Choung
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Yoon
authors.forename: Gyoung Hoon
authors.initials: GH
authors.lastname: Lee
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D047629:Estrogen Receptor beta