title: Association of serum leptin and adiponectin with obesity in asthmatics.
abstract: BACKGROUND
  Mounting evidence implicates obesity as a major risk factor for asthma. Leptin and adiponectin produced by fat tissues play a critical role in the regulation of body weight and allergic inflammation.
  
  
  OBJECTIVE
  The aim of this study was to evaluate the effects of leptin and adiponectin on development of asthma.
  
  
  METHODS
  We measured the leptin and adiponectin in serum from patients with asthma (n = 60) and normal control subjects (n = 30) by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Logarithmic leptin and adiponectin concentration was not different between asthmatics and control subjects. Although the logarithmic adiponectin level was not different by gender in asthmatics, the logarithmic leptin concentration was significantly higher in females than in male asthmatics (2.41 +/- 0.05 ng/mL vs. 2.01 +/- 0.05 ng/mL, p = 0.001). The leptin/adiponectin ratio was also significantly higher in females than in male asthmatics. The leptin/adiponectin ratio was correlated with body mass index (r = 0.210, p = 0.05) in asthmatics.
  
  
  CONCLUSIONS
  Our results suggest that serum leptin and adiponectin may be associated with gender and obesity regardless of development of asthma.
authors.affiliation: Genome Research Center for Allergy and Respiratory Diseases, Division of Allergy and Respiratory Diseases, Soonchunhyang University, Cheonan, Gumi, Republic of Korea.
authors.forename: An-Soo
authors.initials: AS
authors.lastname: Jang
authors.forename: Tae-Hoon
authors.initials: TH
authors.lastname: Kim
authors.forename: Jong-Sook
authors.initials: JS
authors.lastname: Park
authors.forename: Ki-Up
authors.initials: KU
authors.lastname: Kim
authors.forename: Soo-Taek
authors.initials: ST
authors.lastname: Uh
authors.forename: Ki-Hyun
authors.initials: KH
authors.lastname: Seo
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Kim
authors.forename: Gune-Il
authors.initials: GI
authors.lastname: Lim
authors.forename: Choon-Sik
authors.initials: CS
authors.lastname: Park
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D015992:Body Mass Index; D001985:Bronchial Provocation Tests; D004804:Eosinophils / Q000166:cytology; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications; D012737:Sex Factors; D014797:Vital Capacity / Q000502:physiology; D055815:Young Adult
chemical_list: D052242:Adiponectin; D020738:Leptin; D007073:Immunoglobulin E