[Morphofunctional characteristic of the rat distal spinal cord after its complete experimental section with subsequent treadbun training of the animal].
Motor activity of rats has been studied after complete experimental section of spinal cord at the lower thoracic level. A treadbun training performed one day after the operation has been shown to lead to the appearance of movement of hindlimbs and to restoration of function of support of the body weight. In our opinion, the key moment in initiation of locomotor movements is stimulation of foot. Morphoimmunohistochemical study (detection of nuclear protein of proliferation cells, synaptophysin, and glial fibrillary acid protein) of the lumbar enlargement has allowed revealing reorganization of motoneurons, interneurons, and afferent chain in the distal part of the sectioned spinal cord. In trained animals there are observed the normal structure of motoneurons and the appearance of aggregates of synaptophysin-immunoreactive structures lost after the operation.
Gilerovich
E G
EG
Moshonkina
T R
TR
Pavlova
N V
NV
Fedorova
E A
EA
Novikov
G I
GI
Gerasimenko
Iu P
IuP
Otellin
V A
VA
D000818:Animals; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D008124:Locomotion / Q000502:physiology*; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009046:Motor Neurons / Q000166:cytology / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*; D016708:Synaptophysin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D018809:Proliferating Cell Nuclear Antigen; D016708:Synaptophysin