title: Relationship of fibronectin and CD44v6 expression with invasive growth and metastasis of liver cancer.
abstract: Fibronectin and CD44v6 are involved in tumor invasion and metastasis. We examined fibronectin and CD44v6 expression in normal liver and liver cancer by immunohistochemistry. Fibronectin expression was identified in 37.5% of liver cancer specimens. Well-differentiated tumors and expansive growth were associated with continuous periacinar, or cytoplasmic and periacinar fibronectin expression; poorly differentiated and invasive tumors showed interrupted periacinar or vascular mesenchymal fibronectin expression. CD44v6 expression was absent in controls but was observed in 67.5% of liver cancers. Increased CD44v6 expression was more common with poor clinical tumor characteristics. FN and CD44v6 are potential markers for determining liver cancer invasion and metastasis.
authors.affiliation: Department of Surgery, First Hospital of Xi'an Jiaotong University, Xi'an, China.
authors.forename: Rajiv K
authors.initials: RK
authors.lastname: Jha
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Ma
authors.forename: Shahuan
authors.initials: S
authors.lastname: Chen
authors.forename: Huanchen
authors.initials: H
authors.lastname: Sha
authors.forename: Siqin
authors.initials: S
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002454:Cell Differentiation; D049109:Cell Proliferation; D005260:Female; D005353:Fibronectins / Q000032:analysis*; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D007150:Immunohistochemistry; D008099:Liver / Q000737:chemistry; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis
chemical_list: D014408:Biomarkers, Tumor; C112697:CD44v6 antigen; D005353:Fibronectins; D018960:Hyaluronan Receptors