[Prostate-specific antigen and telomerase in prostatic cancers].
A correlation between the blood level of prostate-specific antigen (PSA) and the prostatic tissue activity of telomerase was analyzed in prostate cancer (PC), low- and high-grade prostatic intraepithelial neoplasia (LG PIN, HG PIN) and in benign prostatic hyperplasia (BPH). The study was based on the results of a comprehensive examination of 92 patients from the Clinic of Urology, I. M. Sechenov Moscow Medical Academy. 44% of the patients were diagnosed as having PC; 49% had LG PIN and BPH; 7% had HG PIN and BPH. Active telomerase in the prostate biopsy specimens was found in 98% of the patients with PC, in 33% of those with HG PIN, and in 20% of those with LG PIN. When active telomerase was detected in the prostate biopsy specimens of patients with urological cancer (PC, PIN, BPH, the blood content of total PSA) was statistically significantly higher than that in the absence of this enzyme.
Poliakovskiĭ
K A
KA
Glukhov
A I
AI
zezerov
E G
EG
Varshavskiĭ
V A
VA
Vinarov
A Z
AZ
Amosov
A V
AV
Rapoport
L M
LM
Aliaev
Iu G
IuG
Severin
E S
ES
Zimnik
O V
OV
D001706:Biopsy; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D019098:Telomerase / Q000378:metabolism*; D014571:Urologic Neoplasms / Q000201:enzymology / Q000473:pathology
D019098:Telomerase; D017430:Prostate-Specific Antigen