Oxidative stress in cerebrospinal fluid of patients with aseptic and bacterial meningitis.
This study aimed to determine whether patients with aseptic and bacterial meningitis presented alterations in oxidative stress parameters of cerebrospinal fluid (CSF). A total of 30 patients were used in the research. The CSF oxidative stress status has been evaluated through many parameters, such as lipid peroxidation through thiobarbituric acid reactive substances (TBARS) and antioxidant defense systems such as superoxide dismutase (SOD), glutathione S-transferase (GST), reduced glutathione (GSH) and ascorbic acid. TBARS levels, SOD and GST activity increase in aseptic meningitis and in bacterial meningitis. The ascorbic acid concentration increased significantly in patients with both meningitis types. The reduced glutathione levels were reduced in CSF of patients with aseptic and bacterial meningitis. In present study we may conclude that oxidative stress contributes at least in part to the severe neurological dysfunction found in meningitis.
de Menezes
Charlene Cavalheiro
CC
Departamento de Química, Centro de Ciências Naturais e Exatas, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Dorneles
Aracélli Gnatta
AG
Sperotto
Rita Leal
RL
Duarte
Marta Medeiros Frescura
MM
Schetinger
Maria Rosa Chitolina
MR
Loro
Vania Lúcia
VL
D000293:Adolescent; D000328:Adult; D000975:Antioxidants; D001205:Ascorbic Acid / Q000134:cerebrospinal fluid; D005260:Female; D005982:Glutathione Transferase / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid*; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000134:cerebrospinal fluid; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D001205:Ascorbic Acid