title: A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort.
abstract: BACKGROUND
  Current options to promote joint comfort are limited to medicines that can reduce pain but can also have adverse effects. Collagen, a major component of joint cartilage, is found in the diet, particularly in meat. Its hydrolysed form, collagen hydrolysate (CH), is well absorbed. CH may stimulate the joint matrix cells to synthesize collagen, so helping to maintain the structure of the joint and potentially to aid joint comfort.
  
  
  METHODS
  In a randomized, double-blind, controlled multicentre trial, 250 subjects with primary osteoarthritis of the knee were given 10 g CH daily for 6 months.
  
  
  RESULTS
  There was a significant improvement in knee joint comfort as assessed by visual analogue scales to assess pain and the Womac pain subscale. Subjects with the greatest joint deterioration, and with least intake of meat protein in their habitual diets, benefited most.
  
  
  CONCLUSIONS
  CH is safe and effective and warrants further consideration as a food ingredient.
authors.affiliation: Servicio de Reumatología, Hospital del Mar, Barcelona, Spain. pbenito@imas.imim.es
authors.forename: P
authors.initials: P
authors.lastname: Benito-Ruiz
authors.forename: M M
authors.initials: MM
authors.lastname: Camacho-Zambrano
authors.forename: J N
authors.initials: JN
authors.lastname: Carrillo-Arcentales
authors.forename: M A
authors.initials: MA
authors.lastname: Mestanza-Peralta
authors.forename: C A
authors.initials: CA
authors.lastname: Vallejo-Flores
authors.forename: S V
authors.initials: SV
authors.lastname: Vargas-López
authors.forename: R A
authors.initials: RA
authors.lastname: Villacís-Tamayo
authors.forename: L A
authors.initials: LA
authors.lastname: Zurita-Gavilanes
mesh_terms: D000368:Aged; D000818:Animals; D002358:Cartilage, Articular / Q000737:chemistry; D003094:Collagen / Q000494:pharmacology / Q000627:therapeutic use*; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000187:drug effects*; D008297:Male; D008460:Meat; D008875:Middle Aged; D059352:Musculoskeletal Pain / Q000188:drug therapy* / Q000209:etiology; D020370:Osteoarthritis, Knee / Q000150:complications / Q000188:drug therapy*; D011492:Protein Hydrolysates / Q000494:pharmacology / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D011492:Protein Hydrolysates; D003094:Collagen