Surveillance of carbapenem-resistant Pseudomonas aeruginosa isolates from Puerto Rican Medical Center Hospitals: dissemination of KPC and IMP-18 beta-lactamases.
During a 6-month period, 37/513 (7.2%) Pseudomonas aeruginosa isolates belonging to 13 pulsed-field gel electrophoresis (PFGE) groups from Puerto Rican hospitals were carbapenem nonsusceptible. Seven of 37 isolates from four PFGE groups carried bla(IMP-18), and 25/37 isolates from seven PFGE groups carried bla(KPC). The results indicated the clonal spread of bla(KPC)-positive P. aeruginosa isolates into several Puerto Rican hospitals and the dissemination of bla(IMP-18) and bla(KPC) into genetically unrelated isolates.
Wolter
Daniel J
DJ
Center for Research in Anti-Infectives and Biotechnology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA.
Khalaf
Noha
N
Robledo
Iraida E
IE
Vázquez
Guillermo J
GJ
Santé
Maria I
MI
Aquino
Edna E
EE
Goering
Richard V
RV
Hanson
Nancy D
ND
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001425:Bacterial Outer Membrane Proteins / Q000502:physiology; D015780:Carbapenems / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D026901:Membrane Transport Proteins / Q000502:physiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D018272:Porins / Q000502:physiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics / Q000502:physiology*
D001425:Bacterial Outer Membrane Proteins; D015780:Carbapenems; D026901:Membrane Transport Proteins; C118598:MexA protein, Pseudomonas aeruginosa; D018272:Porins; C077157:OprD protein, Pseudomonas aeruginosa; C434283:beta-lactamase KPC-1; D001618:beta-Lactamases; C527279:beta-lactamase IMP-18, Pseudomonas aeruginosa