Cu(II)-hydrotalcite as an efficient heterogeneous catalyst for Huisgen [3+2] cycloaddition.
Top Cat! Cu(II)-hydrotalcite (HT) is used as a catalyst for the regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles by [3+2] cycloaddition of various azides and alkynes. The catalyst enjoys advantages such as faster reactivity, good stability, reusability, high catalytic activity without any additives at room temperature, and does not require a nitrogen atmosphere for this "click-chemistry" transformation.
Namitharan
Kayambu
K
School of Chemistry, Madurai Kamaraj University, Madurai, 625021, India.
Kumarraja
Mayilvasagam
M
Pitchumani
Kasi
K
D000480:Alkynes / Q000737:chemistry*; D000536:Aluminum Hydroxide / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D008276:Magnesium Hydroxide / Q000737:chemistry*; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis*
D000480:Alkynes; D001386:Azides; D014230:Triazoles; C010467:hydrotalcite; D000536:Aluminum Hydroxide; D003300:Copper; D008276:Magnesium Hydroxide