Total synthesis of (+/-)-neovibsanin B.
(+/-)-Neovibsanin B was synthesized based on a DMI-accelerated intramolecular Diels-Alder reaction followed by oxy-Michael addition-lactonization. The synthetic (+/-)-neovibsanin B induced similar morphological changes in NGF-mediated PC12 cells compared with natural (+)-neovibsanin B.
Imagawa
Hiroshi
H
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cyo, Tokushima 770. imagawa@ph.bunri-u.ac.jp
Saijo
Hayato
H
Kurisaki
Takahiro
T
Yamamoto
Hirofumi
H
Kubo
Miwa
M
Fukuyama
Yoshiyasu
Y
Nishizawa
Mugio
M
D000818:Animals; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D020932:Nerve Growth Factor / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D013237:Stereoisomerism
D004224:Diterpenes; C539540:neovibsanin A; D020932:Nerve Growth Factor