Effects of long-term administration of royal jelly on pituitary weight and gene expression in middle-aged female rats.
To determine the effects of ingested royal jelly (RJ) on the pituitary in middle-aged female rats, we performed a long-term RJ administration test. Several animals showed age-related increases in pituitary weight, and RJ administration compensated for the increase. RJ tended to down-regulate prolactin mRNA and up-regulated thyroid-stimulating hormone beta mRNA in the pituitary. This suggests that RJ compensates for age-associated decline in pituitary functions.
Narita
Yukio
Y
Nagaragawa Research Center, API Co., Ltd., Nagara, Gifu, Japan.
Ohta
Shozo
S
Suzuki
Kazu-Michi
KM
Nemoto
Tomoko
T
Abe
Keiko
K
Mishima
Satoshi
S
D000375:Aging / Q000187:drug effects / Q000235:genetics; D000818:Animals; D005227:Fatty Acids / Q000008:administration & dosage* / Q000494:pharmacology*; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000033:anatomy & histology* / Q000187:drug effects*; D010907:Pituitary Hormones / Q000235:genetics; D011388:Prolactin / Q000097:blood / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013974:Thyroxine / Q000097:blood; D013997:Time Factors; D000099219:Royal Jelly
D005227:Fatty Acids; D010907:Pituitary Hormones; D011388:Prolactin; D013974:Thyroxine; D000099219:Royal Jelly