title: Extended liver resection for intrahepatic cholangiocarcinoma: A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification.
abstract: OBJECTIVE
  The present study was conducted to analyze the outcome after liver resection for intrahepatic cholangiocarcinoma (IHC) and to compare the prognostic accuracy of the fifth and sixth editions of the TNM classification of malignant tumors.
  
  
  BACKGROUND
  A comparison of the prognostic accuracy of the fifth and sixth editions of the TNM classification of malignant tumors is missing for IHC as yet. The present report is, to our knowledge, the largest series on surgical resection of IHC in the world literature and the first comparison of long-term outcome according to the fifth and sixth edition of the TNM classification of malignant tumors.
  
  
  METHODS
  From 1988 to 2007, 195 liver resections for IHC were performed in our institution. Staging was performed according to the liver chapters of the fifth and sixth edition of the TNM classification of malignant tumors.
  
  
  RESULTS
  In a multivariate analysis of prognostic variables, R0-resection, UICC-stage I/II according to the sixth edition, highly or moderately differentiated IHC, and lymph node negative IHC were identified as favorable prognostic variables. UICC-stage IIIc of the sixth edition, which was almost identical to the group of lymph node positive IHC was identified as unfavorable predictor of postoperative prognosis. Formally, curative resections (R0-resections) were achieved in 138 patients (71%). One- and 5-year survival rates after R0-resections were 72.4% and 30.4%, respectively.
  
  
  CONCLUSIONS
  Extended resections for IHC resulted in a favorable rate of R0-resection, which is the most important prognostic variable. Staging of IHC according to sixth edition of the TNM classification is superior in comparison with the fifth edition as indicated by the results of the multivariate analysis.
authors.affiliation: Department of General, Visceral, and Transplantation Surgery, Charité Universitaetsmedzin Berlin, Germany. sven.jonas@medizin.uni-leipzig.de
authors.forename: Sven
authors.initials: S
authors.lastname: Jonas
authors.forename: Armin
authors.initials: A
authors.lastname: Thelen
authors.forename: Christoph
authors.initials: C
authors.lastname: Benckert
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Biskup
authors.forename: Ulf
authors.initials: U
authors.lastname: Neumann
authors.forename: Birgit
authors.initials: B
authors.lastname: Rudolph
authors.forename: Enrique
authors.initials: E
authors.lastname: Lopez-Häänninen
authors.forename: Peter
authors.initials: P
authors.lastname: Neuhaus
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001650:Bile Duct Neoplasms / Q000473:pathology* / Q000601:surgery; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000145:classification*; D011379:Prognosis; D016896:Treatment Outcome