title: [Acute limbic encephalitis and NMDA type-glutamate receptor].
abstract: We compared clinical characteristics and autoantibodies against GluRepsilon2 between 95 patients with nonparaneoplastic non-herpetic acute limbic encephalitis (NPNHALE) and 19 patients with non-herpetic acute encephalitis accompanying ovarian teratoma (NHAE-OT). Onset age (mean +/- SD) was 27.7 +/- 18.6 years old in NPNHALE, 27.5 +/- 6.5 in NHALE-OT. Preceding factors were found in 63.8% of patients with NPNHALE and 89.5% of patients with NHALE-OT (Fisher's exact test, p = 0.025), and major preceding factors were upper respiratory infections or fever in both groups. Symptoms at the onset were disorder of behavior and talk > seizures > impairment of consciousness in NPNHALE, and disorder of behavior and talk > seizures > disorientation in NHALE-OT. Symptoms at the acute stage were similar between NPNHALE and NHAE-OT, but duration of hospital stay was longer in NHAE-OT (209.0 days) than NPNHALE (87.5 days) (Mann Whitney test, p<0.0001). At the onset, cell counts in CSF were 51.6 +/- 66.4/mm3 and protein levels were 35.4 +/- 14.7 mg/dl, and IgG levels were 6.6 +/- 4.2 mg/dl in NHAE-OT, and these data were not significantly different between NPNHALE and NHAE-OT. In acute stage, autoantibodies against whole molecule of GluRepsilon2 in CSF were detected in 51.8% (29/56) of adult NPNHALE, and 40% (6/15) of NHAE-OT patients by immunoblot. These autoantibodies in both groups included epitopes to n-terminal of GluRepsilon2. Antibodies against NMDAR complex (Dalmau's method) in CSF were detected in 90.9% (10/11) of NHAE-OT patients.
authors.affiliation: National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders.
authors.forename: Yukitoshi
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Etsuko
authors.initials: E
authors.lastname: Yamazaki
authors.forename: Shigeko
authors.initials: S
authors.lastname: Nishimura
authors.forename: Hisano
authors.initials: H
authors.lastname: Tsunogae
authors.forename: Kenji
authors.initials: K
authors.lastname: Niwa
authors.forename: Josep
authors.initials: J
authors.lastname: Dalmau
authors.forename: Katsumi
authors.initials: K
authors.lastname: Imai
authors.forename: Tateki
authors.initials: T
authors.lastname: Fujiwara
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies; D002648:Child; D002675:Child, Preschool; D000939:Epitopes; D005260:Female; D006801:Humans; D020363:Limbic Encephalitis; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms; D016194:Receptors, N-Methyl-D-Aspartate / Q000276:immunology*; D013724:Teratoma; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D000939:Epitopes; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate