Emerging roles of NAD+ and its metabolites in cell signaling.
Nicotinamide adenine dinucleotide (NAD(+)) is the universal currency of energy metabolism and electron transfer. Recent studies indicate that apart from its role as a coenzyme, NAD(+) and its metabolites also function in cell signaling pathways; for example, they are substrates for nucleotide-metabolizing enzymes and ligands for extra- and intracellular receptors and ion channels. Moreover, the NAD(+) and NAD(+) phosphate metabolites adenosine 5'-diphosphoribose (ADP-ribose), cyclic ADP-ribose, and nicotinic acid adenine dinucleotide phosphate (NAADP) have emerged as key second messengers in Ca(2+) signaling. A symposium in Hamburg, Germany, brought together 120 researchers from various fields, who were all engaged in the molecular characterization of the key players of NAD(+) signaling (www.NAD2008.de).
Koch-Nolte
Friedrich
F
Institute of Immunology, Diagnostic Department, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, Hamburg, Germany. nolte@uke.de
Haag
Friedrich
F
Guse
Andreas H
AH
Lund
Frances
F
Ziegler
Mathias
M
D000246:Adenosine Diphosphate Ribose / Q000378:metabolism; D000818:Animals; D002468:Cell Physiological Phenomena; D004734:Energy Metabolism; D006801:Humans; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D009536:Niacinamide / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D009243:NAD; D000246:Adenosine Diphosphate Ribose; D009536:Niacinamide; D009249:NADP