Serum retinal-binding protein 4 is positively related to insulin resistance in Chinese subjects with type 2 diabetes.
BACKGROUND
Retinol-binding protein 4 (RBP4) may play a role in the development of insulin resistance (IR).


OBJECTIVE
To study the relationship between serum RBP4 levels and IR in Chinese subjects with type 2 diabetic patients.


METHODS
Fasting serum RBP4 levels in subjects with type 2 diabetes (T2DM) and normal glucose tolerance (NGT) were measured by enzyme-linked immune assay (ELISA). Insulin sensitivity was assessed with insulin resistance index (HOMA-IR), the anthropometrical parameters such as body mass index (BMI), waist hip ratio (WHR) were evaluated and fasting blood glucose (FBG), HBA1C, lipids and fasting insulin levels were also measured.


RESULTS
Serum RBP4 levels were found to correlate positively with HOMA-IR (r=0.257, P=0.024) in type 2 diabetic patients. A correlation analysis showed that serum RBP4 levels also correlate with sex, BMI, WHR, TG and FINS, respectively (P<0.05). A stepwise linear multiple regression model revealed that BMI and sex were significant determinants of RBP4.


CONCLUSIONS
There is a positive relationship between RBP4 and IR in type 2 diabetic patients. RBP4 may play a role in pathogenesis of T2DM.
Cheng
Xingbo
X
Department of Endocrinology & Metabolism, the First Affiliated Hospital of Soochow University, Suzhou 215006, Jiangsu, China. mcheng1982@yahoo.com
Zhang
Hui
H
D000328:Adult; D000368:Aged; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*; D012737:Sex Factors; D049629:Waist-Hip Ratio
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D054839:Retinol-Binding Proteins, Plasma