title: Antiglucocorticoids, neurogenesis and depression.
abstract: Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.
authors.affiliation: LACDR/Medical Pharmacology Department, Leiden University, Gorlaeus Laboratory, Einsteinweg 55, 2333CC Leiden, The Netherlands.
authors.forename: Carlos P
authors.initials: CP
authors.lastname: Fitzsimons
authors.forename: Lenneke W A
authors.initials: LW
authors.lastname: van Hooijdonk
authors.forename: John A
authors.initials: JA
authors.lastname: Morrow
authors.forename: Bernard W M M
authors.initials: BW
authors.lastname: Peeters
authors.forename: Niall
authors.initials: N
authors.lastname: Hamilton
authors.forename: Mark
authors.initials: M
authors.lastname: Craighead
authors.forename: Erno
authors.initials: E
authors.lastname: Vreugdenhil
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism*; D005938:Glucocorticoids / Q000037:antagonists & inhibitors*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008958:Models, Molecular; D009417:Nerve Tissue / Q000254:growth & development*; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism / Q000523:psychology
chemical_list: D000928:Antidepressive Agents; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid