The Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 and the risk of colorectal cancer.
OBJECTIVE
The purpose of this study is to investigate whether the Ile646Val (2073A>G) polymorphism in the kinase-binding domain of A-kinase anchoring protein 10 (AKAP10) is related to the risk of colorectal cancer (CRC), clinicopathological variables and the environmental factors for the development of CRC.


METHODS
Applying TaqMan allelic discrimination, we investigated AKAP10 Ile646Val (2073A>G) polymorphism in 288 Chinese CRC patients and 281 healthy controls.


RESULTS
Logistic regression analysis revealed a significant association of AKAP10 Ile646Val (2073A>G) polymorphism with increased CRC risk (adjusted OR = 1.44, 95% CI 1.01-2.07, p = 0.02). Stratification analysis showed that the increased risk associated with the variant genotypes (GG+AG) was more evident in male subjects (adjusted OR = 1.48, 95% CI 0.94-2.34, p = 0.03). Compared with the AA genotype, the adjusted OR for the variant genotypes was 1.81 (95% CI 1.08-3.05, p = 0.01) among young subjects (age <57 years). Among individuals who did not smoke or who smoked lightly, there was a significantly increased risk with the variant genotypes (adjusted OR = 1.66, 95% CI 1.08-2.56, p = 0.02). We did not observe a relationship between the AKAP10 polymorphism and other clinicopathological and environmental factors.


CONCLUSIONS
Our data suggested that the AKAP10 2073A>G variation is associated with an increased risk of CRC in the Chinese population.
Wang
Mo-Jin
MJ
Institute of Digestive Surgery, Department of Colorectal Surgery and National Key Laboratory of Biotherapy of West China Hospital, Sichuan University, Chengdu, China.
Zhou
Zong-Guang
ZG
Wang
Ling
L
Yu
Yong-Yang
YY
Zhang
Peng
P
Zhang
Yi
Y
Cui
Chang-Fu
CF
Yang
Lie
L
Li
Yuan
Y
Zhou
Bin
B
Sun
Xiao-Feng
XF
D054758:A Kinase Anchor Proteins / Q000235:genetics*; D000328:Adult; D000367:Age Factors; D000368:Aged; D015179:Colorectal Neoplasms / Q000209:etiology / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012727:Sex Characteristics; D012907:Smoking / Q000009:adverse effects
D054758:A Kinase Anchor Proteins; C484639:AKAP10 protein, human