title: Total synthesis of amidepsine B and revision of its absolute configuration.
abstract: The total synthesis of (-)-amidepsine B, a potent diacylglycerol acyltransferase inhibitor, has been achieved. This synthetic study resulted in the revision of the previously assigned stereostructure of the natural amidepsine B and determined the absolute configuration.
authors.affiliation: School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Nagamitsu
authors.forename: Kaori
authors.initials: K
authors.lastname: Marumoto
authors.forename: Asami
authors.initials: A
authors.lastname: Nagayasu
authors.forename: Takeo
authors.initials: T
authors.lastname: Fukuda
authors.forename: Shiho
authors.initials: S
authors.lastname: Arima
authors.forename: Ryuji
authors.initials: R
authors.lastname: Uchida
authors.forename: Taichi
authors.initials: T
authors.lastname: Ohshiro
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Harigaya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Omura
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D062385:Hydroxybenzoates / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004791:Enzyme Inhibitors; D062385:Hydroxybenzoates; D007202:Indicators and Reagents; C096618:amidepsine B; D051048:Diacylglycerol O-Acyltransferase