title: A tandem triplication, trp(1)(q21q32), in a patient with follicular lymphoma: a case study and review of the literature.
abstract: A 1q triplication is a rare karyotypic event in hematologic malignancies, with 26 cases of 1q triplication reported in the literature. Although 1q duplication or triplication is present with a high incidence in Burkitt lymphoma and Fanconi anemia, there have been no detailed reports of an association between non-Burkitt type lymphomas and 1q triplication. Presented here is the case of a 69-year-old man with follicular lymphoma (FL) and 1q triplication, with a review of the pertinent literature. The patient was diagnosed with FL with bone marrow involvement; his bone marrow chromosome study revealed 50,XY,trp(1)(q21q32),+3,+add(3)(q21),+7,+9,add(13)(p11.2)[11]/51 approximately 52,idem,+19,+22[8]/46,XY[3]. Review of the Mitelman Database of Chromosome Aberrations in Cancer revealed 7 previous cases of non-Burkitt type lymphoma (including FL) with 1q triplication. On the basis of these eight cases, we conclude that 1q triplication represents a rare secondary genetic event with prognostic significance in patients with FL or other non-Burkitt types of lymphoma. Further studies are needed to investigate these rare 1q triplication in hematologic malignancies.
authors.affiliation: Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, Korea.
authors.forename: Tae Sung
authors.initials: TS
authors.lastname: Park
authors.forename: Seung Tae
authors.initials: ST
authors.lastname: Lee
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Song
authors.forename: Kyung-A
authors.initials: KA
authors.lastname: Lee
authors.forename: Juwon
authors.initials: J
authors.lastname: Kim
authors.forename: Sue Jung
authors.initials: SJ
authors.lastname: Kim
authors.forename: Jung-Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Sungwook
authors.initials: S
authors.lastname: Song
authors.forename: Jong Rak
authors.initials: JR
authors.lastname: Choi
mesh_terms: D000368:Aged; D002878:Chromosomes, Human, Pair 1; D020732:Cytogenetic Analysis; D020440:Gene Duplication; D006801:Humans; D008224:Lymphoma, Follicular / Q000235:genetics*; D008297:Male; D020080:Tandem Repeat Sequences; D014314:Trisomy