title: Relationship between myocardial beta-adrenergic receptor characteristics and the incidence of ascites in broiler chickens.
abstract: The present study was carried out to determine, first, the cardiac beta-adrenergic receptor characteristics of normal chickens and chickens with heart failure and, second, the characteristics of myocardial beta-adrenergic receptors in non-hypertrophied hearts in broilers exposed to two different altitude and temperature programmes. The density of beta-adrenergic receptors was significantly lower in myocardial cells in right ventricular failure birds compared with healthy birds. The binding capacity of beta-adrenergic receptors was reduced in the non-hypertrophied ventricles after exposure to high altitude in the younger but not in older chickens. At both altitudes, beta-adrenergic receptor binding capacity was not significantly different in low temperature compared with normal temperature birds. These data support the hypothesis of beta-adrenergic receptor downregulation as one of the mechanisms of cardiac cell adaptation to hypertrophy or hypoxia. Second, the acclimatization to high altitude in older chickens resulted in a normalization of beta-receptor capacity in those broilers that were not affected by right ventricular failure and ascites.
authors.forename: M
authors.initials: M
authors.lastname: Hassanzadeh
authors.forename: J
authors.initials: J
authors.lastname: Buyse
authors.forename: E
authors.initials: E
authors.lastname: Decuypere