Emergence of targeted molecular imaging in atherosclerotic cardiovascular disease.
Atherosclerosis, a systemic disease, remains one of the leading causes of morbidity and mortality in the world. Our improved understanding of the molecular mechanisms underlying atherosclerotic lesion progression and sudden transformation into unstable plaques, indicate complex interactions of lipid metabolism, inflammatory processes and genetic predisposition. Currently, novel imaging approaches to visualize the process of atherosclerosis, particularly at the molecular level, are actively being developed. Important targets include inflammatory and endothelial cells, as well as apoptosis and angiogenesis. The next decade should solidify the role of targeted molecular imaging in all aspects of cardiovascular medicine.
Desai
Milind Y
MY
Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J1-15, Cleveland, OH 44195, USA. desaim2@ccf.org
Schoenhagen
Paul
P
D000818:Animals; D017209:Apoptosis; D050197:Atherosclerosis / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D003952:Diagnostic Imaging / Q000379:methods*; D018450:Disease Progression; D042783:Endothelial Cells / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006801:Humans; D050356:Lipid Metabolism; D009389:Neovascularization, Pathologic / Q000175:diagnosis