title: Methods for analysis in pharmacogenomics: lessons from the Pharmacogenetics Research Network Analysis Group.
abstract: Each year, the Pharmacogenetics Research Network (PGRN) holds an analysis workshop for the members of the PGRN to share new methodologies, study design approaches and to discuss real data applications. This event is closed to members of the PGRN, but the methods presented are relevant to others conducting pharmacogenomics research. This special report describes many of the novel approaches discussed at the workshop and provides a resource for investigators in the field performing pharmacogenomics data analysis. While the focus is pharmacogenomics, the methods discussed are far ranging and have relevance to all types of genetic association studies: identifying noncoding variants and tag-SNPs, haplotype analysis, multivariate techniques, quantitative trait analysis, gene-gene and gene-environment interactions, and genome-wide association studies. The goal is to introduce readers to the topics discussed at the workshop and provide a direction for future development of analysis tools and methods for analysis of pharmacogenomic data.
authors.affiliation: Stanford University, CA, USA.
authors.forename: Balaji S
authors.initials: BS
authors.lastname: Srinivasan
authors.forename: Jinbo
authors.initials: J
authors.lastname: Chen
authors.forename: Cheng
authors.initials: C
authors.lastname: Cheng
authors.forename: David
authors.initials: D
authors.lastname: Conti
authors.forename: Shiwei
authors.initials: S
authors.lastname: Duan
authors.forename: Brooke L
authors.initials: BL
authors.lastname: Fridley
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Gu
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
authors.forename: Eric
authors.initials: E
authors.lastname: Jorgenson
authors.forename: Aldi
authors.initials: A
authors.lastname: Kraja
authors.forename: Jessica
authors.initials: J
authors.lastname: Lasky-Su
authors.forename: Lang
authors.initials: L
authors.lastname: Li
authors.forename: Andrei
authors.initials: A
authors.lastname: Rodin
authors.forename: Dai
authors.initials: D
authors.lastname: Wang
authors.forename: Mike
authors.initials: M
authors.lastname: Province
authors.forename: Marylyn D
authors.initials: MD
authors.lastname: Ritchie
mesh_terms: D004358:Drug Therapy / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D004777:Environment; D014644:Genetic Variation; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D010597:Pharmacogenetics / Q000379:methods*; D010641:Phenotype