title: iDQC anisotropy map imaging for tumor tissue characterization in vivo.
abstract: Intermolecular double quantum coherences (iDQCs), signals that result from simultaneous transitions of two or more separated spins, are known to produce images that are highly sensitive to subvoxel structure, particularly local anisotropy. Here we demonstrate how iDQCs signal can be used to efficiently detect the anisotropy created in breast tumor tissues and prostate tumor tissues by targeted (LHRH-conjugated) superparamagnetic nanoparticles (SPIONs), thereby distinguishing the necrotic area from the surrounding tumor tissue.
authors.affiliation: Center for Molecular and Biomolecular Imaging, Duke University, Durham, North Carolina 27710, USA. rtb9@duke.edu
authors.forename: Rosa T
authors.initials: RT
authors.lastname: Branca
authors.forename: Yuming M
authors.initials: YM
authors.lastname: Chen
authors.forename: Vladimir
authors.initials: V
authors.lastname: Mouraviev
authors.forename: Gigi
authors.initials: G
authors.lastname: Galiana
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Jenista
authors.forename: Challa
authors.initials: C
authors.lastname: Kumar
authors.forename: Carola
authors.initials: C
authors.lastname: Leuschner
authors.forename: Warren S
authors.initials: WS
authors.lastname: Warren
mesh_terms: D000465:Algorithms; D000818:Animals; D016880:Anisotropy; D001943:Breast Neoplasms / Q000175:diagnosis*; D045744:Cell Line, Tumor; D003287:Contrast Media; D005260:Female; D005290:Ferric Compounds; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008297:Male; D051379:Mice; D008819:Mice, Nude; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide