title: The relationship of donor source and age on short- and long-term allograft survival in pediatric renal transplantation.
abstract: Limited pediatric data on allograft survival from advanced aged kidney donors exist. To determine the influence of donor source and age on allograft survival in pediatric renal transplant recipients, we analyzed the OPTN database. Allograft survival for 7291 pediatric renal transplants was evaluated. Up to five yr post-transplantation, graft survival was higher for LD vs. DD recipients. At seven yr, allograft survival was 71% in 18-54 yr-old LD recipients, 59.1% in >or=55 yr-old LD, and 45.1% in >or=50 yr-old DD recipients. An approximate 35% improvement in allograft survival in 18-54 yr-old LD recipients was observed. Multivariate results showed that recipients of LD 35-49 (aRR 0.66, 95% CI 0.55-0.80) and LD 50-54 (aRR 0.65, 95% CI 0.45-0.94) have a graft survival advantage over the ideal DD. In LD >or=55 yr, no improvement in graft survival was observed when compared with the 18-34 yr-old DD. In summary, we observed in a pediatric population, <55 yr-old LD kidneys afford improved long-term allograft survival when compared with DD kidney recipients. Increasing awareness of the long-term graft survival advantage for children receiving an LD kidney, even from older donors, should be a priority.
authors.affiliation: Division of Pediatric Nephrology, Levine Children's Hospital at Carolinas Medical Center, Charlotte, NC, USA.
authors.forename: A W
authors.initials: AW
authors.lastname: Dale-Shall
authors.forename: J M
authors.initials: JM
authors.lastname: Smith
authors.forename: M A
authors.initials: MA
authors.lastname: McBride
authors.forename: S R
authors.initials: SR
authors.lastname: Hingorani
authors.forename: R A
authors.initials: RA
authors.lastname: McDonald
mesh_terms: D000293:Adolescent; D000328:Adult; D002102:Cadaver; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016030:Kidney Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D014019:Tissue Donors; D016896:Treatment Outcome