title: Occurrence of hepatocellular carcinoma after hepatoblastoma resection in an adult with hepatitis C virus.
abstract: Hepatoblastoma is a rare malignancy in adults. It is often diagnosed after the appearance of symptoms, therefore, the tumor size tends to be larger. In patients with no indication for a hepatic resection, the prognosis of adult hepatoblastoma is quite poor. A 54-year-old man with hepatitis C virus-associated liver cirrhosis was initially treated with a hepatic resection for a hepatic tumor, 3 cm in diameter. The tumor consisted of osteoid-like and cartilaginous foci, myxomatous stroma, and poorly differentiated hepatocellular carcinomatous cells and was diagnosed as a mixed epithelial and mesenchymal hepatoblastoma. Two years after the first operation, multicentric hepatocellular carcinomas developed in the remnant liver and were successfully treated with a secondary hepatic resection combined with radio-frequency ablation. The patient is now alive with no recurrence at 5 years after the initial hepatectomy. To the best of our knowledge, the primary hepatoblastoma was the smallest such tumor reported and this is the first report of a metachronous hepatoblastoma and hepatocellular carcinoma in an adult hepatitis patient.
authors.affiliation: Department of Gastroenterological Surgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.
authors.forename: Toshiro
authors.initials: T
authors.lastname: Masuda
authors.forename: Toru
authors.initials: T
authors.lastname: Beppu
authors.forename: Kei
authors.initials: K
authors.lastname: Horino
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Komori
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hayashi
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Okabe
authors.forename: Ryuu
authors.initials: R
authors.lastname: Ootao
authors.forename: Hasita
authors.initials: H
authors.lastname: Horlad
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Baba
authors.forename: Shiho
authors.initials: S
authors.lastname: Miyase
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takamori
authors.forename: Hideo
authors.initials: H
authors.lastname: Baba