title: Methodology for the qualitative screening of parallel arrays of potential Am3+ ligands using a photographic film.
abstract: A screening method for parallel Am(3+) ligand libraries is presented. The method makes use of alpha-radiation in combination with a photographic film to detect the complexed Am(3+). After screening and development of the film spots of varying intensities are obtained. The intensities of the spots correspond with the amount of complexed Am(3+). This allows a fast discrimination between the Am(3+) complexation efficiencies of ligands from large libraries. Depending on the exposure time of the film, activities as small as 5Bq (241)Am can be detected. Using internal standards a semi-quantitative assessment can be performed.
authors.affiliation: Laboratory of Molecular Nanofabrication, Mesa+ Research Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
authors.forename: Henk H
authors.initials: HH
authors.lastname: Dam
authors.forename: Tanja
authors.initials: T
authors.lastname: Tomasberger
authors.forename: David N
authors.initials: DN
authors.lastname: Reinhoudt
authors.forename: Willem
authors.initials: W
authors.lastname: Verboom