title: Effects of beta-alanine supplementation and high-intensity interval training on endurance performance and body composition in men; a double-blind trial.
abstract: BACKGROUND
  Intermittent bouts of high-intensity exercise result in diminished stores of energy substrates, followed by an accumulation of metabolites, promoting chronic physiological adaptations. In addition, beta-alanine has been accepted has an effective physiological hydrogen ion (H+) buffer. Concurrent high-intensity interval training (HIIT) and beta-alanine supplementation may result in greater adaptations than HIIT alone. The purpose of the current study was to evaluate the effects of combining beta-alanine supplementation with high-intensity interval training (HIIT) on endurance performance and aerobic metabolism in recreationally active college-aged men.
  
  
  METHODS
  Forty-six men (Age: 22.2 +/- 2.7 yrs; Ht: 178.1 +/- 7.4 cm; Wt: 78.7 +/- 11.9; VO2peak: 3.3 +/- 0.59 l.min-1) were assessed for peak O2 utilization (VO2peak), time to fatigue (VO2TTE), ventilatory threshold (VT), and total work done at 110% of pre-training VO2peak (TWD). In a double-blind fashion, all subjects were randomly assigned into one either a placebo (PL - 16.5 g dextrose powder per packet; n = 18) or beta-alanine (BA - 1.5 g beta-alanine plus 15 g dextrose powder per packet; n = 18) group. All subjects supplemented four times per day (total of 6 g/day) for the first 21-days, followed by two times per day (3 g/day) for the subsequent 21 days, and engaged in a total of six weeks of HIIT training consisting of 5-6 bouts of a 2:1 minute cycling work to rest ratio.
  
  
  RESULTS
  Significant improvements in VO2peak, VO2TTE, and TWD after three weeks of training were displayed (p < 0.05). Increases in VO2peak, VO2TTE, TWD and lean body mass were only significant for the BA group after the second three weeks of training.
  
  
  CONCLUSIONS
  The use of HIIT to induce significant aerobic improvements is effective and efficient. Chronic BA supplementation may further enhance HIIT, improving endurance performance and lean body mass.
authors.affiliation: Metabolic and Body Composition Laboratory, Department of Health and Exercise Science, University of Oklahoma, Norman, OK 73019, USA. jrstout@ou.edu.
authors.forename: Abbie E
authors.initials: AE
authors.lastname: Smith
authors.forename: Ashley A
authors.initials: AA
authors.lastname: Walter
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Graef
authors.forename: Kristina L
authors.initials: KL
authors.lastname: Kendall
authors.forename: Jordan R
authors.initials: JR
authors.lastname: Moon
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Lockwood
authors.forename: David H
authors.initials: DH
authors.lastname: Fukuda
authors.forename: Travis W
authors.initials: TW
authors.lastname: Beck
authors.forename: Joel T
authors.initials: JT
authors.lastname: Cramer
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Stout