title: Differences in feedback- and inhibition-related neural activity in adult ADHD.
abstract: The objective of this study was to examine response inhibition- and feedback-related neural activity in adults with attention deficit hyperactivity disorder (ADHD) using event-related functional MRI. Sixteen male adults with ADHD and 13 healthy/normal controls participated in this study and performed a modified Go/NoGo task. Behaviourally, attention and inhibition problems in the ADHD group were observed; no feedback-related differences between the groups were detected. The neuroimaging data showed that the ADHD group displayed more activation in the inferior frontal gyrus and putamen during response inhibition. During feedback-related processes, the ADHD group displayed less activation in the inferior frontal/orbitofrontal cortex, hippocampus/nucleus accumbens, and caudate nucleus, but more activity in the inferior frontal gyrus. These results indicate that at least two distinguishable underlying brain networks related to response inhibition and feedback are altered in adults with ADHD.
authors.affiliation: Maastricht University, Universiteitssingel 50, Clinical Psychological Science, P.O. Box 616, 6200MD, Maastricht, The Netherlands. Pauline.Dibbets@dmkep.unimaas.nl
authors.forename: Pauline
authors.initials: P
authors.lastname: Dibbets
authors.forename: Lisbeth
authors.initials: L
authors.lastname: Evers
authors.forename: Petra
authors.initials: P
authors.lastname: Hurks
authors.forename: Natalie
authors.initials: N
authors.lastname: Marchetta
authors.forename: Jelle
authors.initials: J
authors.lastname: Jolles
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D005246:Feedback / Q000502:physiology*; D006801:Humans; D007175:Impulsive Behavior / Q000503:physiopathology*; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time; D011795:Surveys and Questionnaires; D013647:Task Performance and Analysis; D055815:Young Adult