title: Practical synthesis of 5-aryl-3-alkylsulfonyl-phenol and 5-aryl-3-arylsulfonyl-phenol libraries.
abstract: A straightforward and cost-effective synthesis of 5-aryl-3-alkylsulfonyl-phenols by a sequential scaffold derivatization strategy has been developed. The procedure is suitable for parallel synthesis of small libraries around the biphenyl privileged core having an unusual 1,3,5-substitution pattern. The synthesis is exemplified by a pilot library of 30 compounds.
authors.affiliation: AMRI, Zahony u 7, 1031 Budapest, Hungary. gyorgy.jeges@amriglobal.com
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Jeges
authors.forename: Tamas
authors.initials: T
authors.lastname: Nagy
authors.forename: Tamas
authors.initials: T
authors.lastname: Meszaros
authors.forename: Jozsef
authors.initials: J
authors.lastname: Kovacs
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Dorman
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Kowalczyk
authors.forename: Robert A
authors.initials: RA
authors.lastname: Goodnow
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010636:Phenols; D054852:Small Molecule Libraries; D013450:Sulfones