title: Mechanotransduction in development: a growing role for contractility.
abstract: Mechanotransduction research has focused historically on how externally applied forces can affect cell signalling and function. A growing body of evidence suggests that contractile forces that are generated internally by the actomyosin cytoskeleton are also important in regulating cell behaviour, and suggest a broader role for mechanotransduction in biology. Although the molecular basis for these cellular forces in mechanotransduction is being pursued in cell culture, researchers are also beginning to appreciate their contribution to in vivo developmental processes. Here, we examine the role for mechanical forces and contractility in regulating cell and tissue structure and function during development.
authors.affiliation: Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors.forename: Michele A
authors.initials: MA
authors.lastname: Wozniak
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Chen
mesh_terms: D000818:Animals; D049109:Cell Proliferation; D003599:Cytoskeleton / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology*; D015398:Signal Transduction