title: [Cryptococcosis in AIDS patients: case study from 1996 to 2006 in Paroissien Hospital].
abstract: Clinic, epidemiological and microbiological characteristics of 128 episodes of cryptococcosis were retrospectively evaluated in 106 positive HIV patients hospitalized at the Paroissien Hospital on period 1996-2007. There were 75 male and 31 female patients, with a median age of 34 years, ranging from 20 to 68 years. Addiction to intravenous drugs was the main cause of HIV infection in 55 patients (51.9%). Cryptococcosis was detected as single episode in 85 patients (80.2%) and as relapse in 19 (17.9%). It appeared as the first marking disease in 36 patients (34.0%). Diagnosis was established in 116 episodes by CSF study (Indian ink, culture, antigen detection), in 9 cases by Cryptococcus sp. recovery from blood cultures, and in 3 cases by antigen detection in patient's serum with a latex reactive. Neurological symptomatology, with headache and fever as the most common signs, was presented by 89.6% of patients. Induction treatment was done in all cases with amphotericin B, and maintenance treatment was carried out with fluconazole. Mortality rate was 35.8%, being higher in those patients who had suffered relapses (41.3%) compared to those who presented a first episode of the mycosis (33.3%).
authors.affiliation: Laboratorio Central, Sección Microbiología, Hospital Interzonal General de Agudos Dr. Diego Paroissien, Av. Brig. Gral. D. J. M. de Rosas 5475, (1765) I. Casanova, La Matanza, Buenos Aires, Argentina. lmonaco@speedy.com.ar
authors.forename: L S
authors.initials: LS
authors.lastname: Mónaco
authors.forename: N
authors.initials: N
authors.lastname: Tamayo Antabak
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology* / Q000382:microbiology; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001118:Argentina / Q000453:epidemiology; D003453:Cryptococcosis / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005334:Fever / Q000209:etiology; D016469:Fungemia / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D006261:Headache / Q000209:etiology; D017052:Hospital Mortality; D006801:Humans; D007297:Inpatients; D008297:Male; D016919:Meningitis, Cryptococcal / Q000134:cerebrospinal fluid / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012309:Risk-Taking; D055815:Young Adult
chemical_list: D000935:Antifungal Agents