title: 18F-FDG-uptake of hepatocellular carcinoma on PET predicts microvascular tumor invasion in liver transplant patients.
abstract: Vascular invasion of hepatocellular carcinoma (HCC) is a major risk factor for poor outcome after liver transplantation (LT). The aim of this retrospective analysis was to assess the value of preoperative positron emission tomography (PET) using (18)F-fluorodeoxyglucose ((18)F-FDG) in liver transplant candidates with HCC for predicting microvascular tumor invasion (MVI) and posttransplant tumor recurrence. Forty-two patients underwent LT for HCC after PET evaluation. Sixteen patients had an increased (18)F-FDG tumor uptake on preoperative PET scans (PET +), while 26 recipients revealed negative PET findings (PET-) pre-LT. PET- recipients demonstrated a significantly better 3-year recurrence-free survival (93%) than PET + patients (35%, p < 0.001). HCC recurrence rate was 50% in the PET + group, and 3.8% in the PET-population (p < 0.001). PET + status was identified as independent predictor of MVI [hazard ratio: 13.4]. Patients with advanced PET negative tumors and patients with HCC meeting the Milan criteria had a comparable 3-year-recurrence-free survival (80% vs. 94%, p = 0.6). Increased (18)F-FDG uptake on PET is predictive for MVI and tumor recurrence after LT for HCC. Its application may identify eligible liver transplant candidates with tumors beyond the Milan criteria.
authors.affiliation: Department of General, Visceral and Vascular Surgery, Friedrich-Schiller-University, Jena, Germany. Arno.Kornberg@med.uni-jena.de
authors.forename: A
authors.initials: A
authors.lastname: Kornberg
authors.forename: M
authors.initials: M
authors.lastname: Freesmeyer
authors.forename: E
authors.initials: E
authors.lastname: Bärthel
authors.forename: K
authors.initials: K
authors.lastname: Jandt
authors.forename: K
authors.initials: K
authors.lastname: Katenkamp
authors.forename: J
authors.initials: J
authors.lastname: Steenbeck
authors.forename: A
authors.initials: A
authors.lastname: Sappler
authors.forename: O
authors.initials: O
authors.lastname: Habrecht
authors.forename: D
authors.initials: D
authors.lastname: Gottschild
authors.forename: U
authors.initials: U
authors.lastname: Settmacher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000098:blood supply* / Q000473:pathology* / Q000601:surgery; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply* / Q000473:pathology* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D049268:Positron-Emission Tomography; D012008:Recurrence; D015996:Survival Rate
chemical_list: D019788:Fluorodeoxyglucose F18