Analysis of 10 X-linked tetranucleotide markers in mixed and isolated populations.
We have applied a recently described X-STRs decaplex to characterize four population groups of the Iberian Peninsula, including two well mixed populations and two relatively isolated ones from Northern Spain, in order to get a better insight about the characteristics of X-STRs in those population types between-population differences in allelic frequencies were relatively small. Nevertheless, Fst values were between 0.2 and 2.7%, figures higher than usually reported for autosomic STRs. This result suggests that when forensic cases originate from relatively isolated groups in western Europe, and a specific reference database is not available, it is probably safe to include a Fst-based correction in the calculations of matching or kinship probabilities.
Zarrabeitia
María T
MT
Unit of Legal Medicine, University of Cantabria, Av Herrera Oria s/n, 39011 Santander, Spain. zarrabet@unican.es
Pinheiro
Fátima
F
de Pancorbo
Marian M
MM
Cainé
Laura
L
Cardoso
Sergio
S
Gusmão
Leonor
L
Riancho
José A
JA
D000483:Alleles; D041321:Chromosomes, Human, X; D016172:DNA Fingerprinting; D005260:Female; D005787:Gene Frequency; D050172:Genes, X-Linked; D005819:Genetic Markers; D005828:Genetics, Population; D005843:Geography; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D011153:Population / Q000235:genetics*; D011156:Population Density; D013030:Spain
D005819:Genetic Markers