title: Acute tumefactive demyelinating lesions in a pediatric patient with known diagnosis of multiple sclerosis: review of the literature and treatment proposal.
abstract: Tumefactive demyelinating lesions are a known but uncommon complication of multiple sclerosis, a disease rarely reported in children. This is the case of a 16-year-old African American patient with multiple sclerosis, who developed 2 tumefactive demyelinating lesions. Review of the literature and our own experience helped formulate an algorithm for therapeutic options during an acute attack.
authors.affiliation: Department of Pediatrics, Division of Child Neurology, Connecticut Children's Medical Center, Hartford, Connecticut 06106, USA.
authors.forename: Jahannaz
authors.initials: J
authors.lastname: Dastgir
authors.forename: Francis J
authors.initials: FJ
authors.lastname: DiMario
mesh_terms: D000208:Acute Disease / Q000628:therapy; D000293:Adolescent; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D003711:Demyelinating Diseases / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D005155:Facial Nerve Diseases / Q000209:etiology; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D006429:Hemiplegia / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000068556:Interferon beta-1a; D016899:Interferon-beta / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D015835:Ocular Motility Disorders / Q000209:etiology; D010291:Paresis / Q000209:etiology; D011149:Pons / Q000473:pathology / Q000503:physiopathology; D012008:Recurrence; D016896:Treatment Outcome; D014717:Vertigo / Q000209:etiology
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D016899:Interferon-beta; D003520:Cyclophosphamide; D008775:Methylprednisolone; D000068556:Interferon beta-1a