Reinnervation cannot be interpreted as an indicator of electrophysiologic improvement in amyothrophic lateral sclerosis.
Denervation and reinnervation comprise a dynamic process that begins in the early periods of amyothrophic lateral sclerosis and lasts until the final individual motor neuron dies. A dynamic process like denervation-reinnervation that is found in the natural course of the disease can not be presented as a neurophysiologic measure. Other parameters, such as motor unit number estimation, compound muscle action potential amplitude and neurophysiologic index, seem more appropriate for therapeutic trials.
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D000200:Action Potentials / Q000502:physiology; D000690:Amyotrophic Lateral Sclerosis / Q000473:pathology / Q000628:therapy*; D015415:Biomarkers; D004576:Electromyography / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008168:Lung / Q000294:innervation; D009046:Motor Neurons / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation; D011999:Recruitment, Neurophysiological / Q000502:physiology; D012129:Respiratory Function Tests / Q000379:methods; D013223:Statistics as Topic; D016896:Treatment Outcome
D015415:Biomarkers