[Experimental study of the phenomenon of antibody dependent tick-borne encephalitis virus infectivity enhancement in vitro].
Phenomenon of antibody dependent tick-borne encephalitis virus (TBEV) infectivity enhancement in the human monocytic cell culture J-96 has been studied. Three specific commercial sera that are generally used for therapy and prevention of TBE in humans were used. Results showed that enhancement of TBEV infectivity was markedly apparent following use of 2 out of 3 studied sera. Data obtained in the study prove that phenomenon of antibody dependent TBEV infectivity enhancement in monocytes cell culture may exist, but conditions for its realization in the organism are very unlikely due to the narrow range of antibodies' concentration and quantity of viral particles. A the same time, the fact of possible aggravation of TBE course after use of specific antisera for treatment and prevention of TBE in humans should not be ignored.
Ozherelkov
S V
SV
Kalinina
E S
ES
Kozhevnikova
T N
TN
Sanin
A V
AV
Timofeeva
T Iu
TIu
Timofeev
A V
AV
Stivenson
D R
DR
D019067:Antibody-Dependent Enhancement; D002460:Cell Line; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology* / Q000472:pathogenicity*; D004675:Encephalitis, Tick-Borne / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D009000:Monocytes / Q000276:immunology / Q000821:virology
D007106:Immune Sera