Inhibitory effect of newly developed CXC-chemokine receptor 4 antagonists on the infection with feline immunodeficiency virus.
CXC-chemokine receptor 4 (CXCR4) functions as a receptor for feline immunodeficiency virus (FIV). Although we previously found that a CXCR4 antagonist, T140, inhibited the FIV replication in vitro, it was not effective in cats infected with FIV because of its low stability in feline serum. To resolve this problem, several T140 derivatives have been developed. Here, we examined the efficacy of T140 analogs, TF14016 and TF14013, on the inhibition of FIV infection. These compounds were shown to significantly inhibit the syncytia formation in CXCR4-expressing cells after co-cultivation with FIV-infected cells and the replication of FIV in a feline lymphoid cultured cell line. These results indicated that TF14016 and TF14013 could be useful as antiviral drugs for cats infected with FIV.
Mizukoshi
Fuminori
F
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo, Japan.
Baba
Kenji
K
Goto-Koshino
Yuko
Y
Setoguchi-Mukai
Asuka
A
Fujino
Yasuhito
Y
Ohno
Koichi
K
Tamamura
Hirokazu
H
Oishi
Shinya
S
Fujii
Nobutaka
N
Tsujimoto
Hajime
H
D000818:Animals; D002371:Cat Diseases / Q000517:prevention & control*; D002415:Cats; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D016180:Lentivirus Infections / Q000517:prevention & control / Q000662:veterinary*; D009842:Oligopeptides / Q000494:pharmacology*; D010455:Peptides / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors*; D014779:Virus Replication / Q000187:drug effects*
C577039:4-fluorobenzoyl-Arg-Arg-Nal-Cys-Tyr-Cit-Lys-Lys-Pro-Tyr-Arg-Cit-Cys-Arg-NH2 (S-S bridged); D009842:Oligopeptides; D010455:Peptides; D019718:Receptors, CXCR4; C116977:T140 peptide