title: The plasma membrane redox system in human platelet functions and platelet-leukocyte interactions.
abstract: The plasma membrane electron transport is crucial for blood coagulation and thrombosis, since reactive oxygen species and thiol changes, generated by plasma membrane redox reactions, modulate activation of platelets, as well as their interaction with leukocytes. Several antioxidants are linked to this system; thus, platelets are also able to counterbalance radical production and to regulate thrombus growth. Aim of this review is to give an update on the plasma membrane redox system in platelets, as well as on its role in platelet functions and leukocyte-platelet cross-talk.
authors.affiliation: Department of Health and Cell Biology, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. delprin@uniroma2.it
authors.forename: Domenico
authors.initials: D
authors.lastname: Del Principe
authors.forename: Gianluca
authors.initials: G
authors.lastname: Frega
authors.forename: Isabella
authors.initials: I
authors.lastname: Savini
authors.forename: M Valeria
authors.initials: MV
authors.lastname: Catani
authors.forename: Antonello
authors.initials: A
authors.lastname: Rossi
authors.forename: Luciana
authors.initials: L
authors.lastname: Avigliano
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D001777:Blood Coagulation; D001792:Blood Platelets / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004579:Electron Transport; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D010084:Oxidation-Reduction; D015539:Platelet Activation; D017382:Reactive Oxygen Species / Q000097:blood; D015398:Signal Transduction; D013927:Thrombosis / Q000097:blood
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species