title: Transmission of IncN plasmids carrying blaCTX-M-1 between commensal Escherichia coli in pigs and farm workers.
abstract: CTX-M-1-producing Escherichia coli were isolated from 56 pigs, three farm personnel, two manure samples, and two air samples from two Danish pig farms where an association between prophylactic ceftiofur use and the occurrence of cephalosporin resistance was previously demonstrated. Human, animal, and environmental strains displayed high genetic diversity but harbored indistinguishable or closely related IncN plasmids carrying bla(CTX-M-1), indicating that IncN plasmids mediating cephalosporin resistance were transmitted between pigs and farm workers across multiple E. coli lineages.
authors.affiliation: Department of Veterinary Pathobiology, Faculty of Life Sciences, University of Copenhagen, Frederiksberg C, Denmark. asm@life.ku.dk
authors.forename: Arshnee
authors.initials: A
authors.lastname: Moodley
authors.forename: Luca
authors.initials: L
authors.lastname: Guardabassi
mesh_terms: D000818:Animals; D018550:Cephalosporin Resistance; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D009784:Occupational Diseases / Q000382:microbiology / Q000517:prevention & control; D010957:Plasmids; D012150:Polymorphism, Restriction Fragment Length; D013552:Swine / Q000382:microbiology*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: C055184:beta-lactamase TEM-3; D001618:beta-Lactamases