title: Localized hypertrophic neuropathy: a case report and review of the literature.
abstract: The case is presented of a 71-year-old man with a 6-year history of symptoms suggestive of carpal tunnel syndrome, which did not improve despite two surgical procedures. On further investigation, a fusiform enlargement of the median nerve was found above the elbow, which was found on biopsy to be localized hypertrophic neuropathy (LHN). This case is the first to be described affecting the median nerve. The literature regarding LHN is reviewed, with discussion of the differential diagnoses and possible etiology of this rare lesion.
authors.affiliation: Hanson Institute Center for Neurological Diseases, Institute of Medical and Veterinary Science, Discipline of Pathology, Australia. barbara.koszyca@imvs.sa.gov.au
authors.forename: B
authors.initials: B
authors.lastname: Koszyca
authors.forename: N
authors.initials: N
authors.lastname: Jones
authors.forename: C
authors.initials: C
authors.lastname: Kneebone
authors.forename: P
authors.initials: P
authors.lastname: Blumbergs
mesh_terms: D000368:Aged; D002349:Carpal Tunnel Syndrome / Q000209:etiology / Q000601:surgery; D018149:Glucose Intolerance / Q000150:complications; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006984:Hypertrophy; D008279:Magnetic Resonance Imaging; D008297:Male; D020423:Median Neuropathy / Q000150:complications / Q000473:pathology*; D019637:Orthopedic Procedures; D010523:Peripheral Nervous System Diseases / Q000150:complications / Q000473:pathology*; D012583:Schwann Cells / Q000473:pathology*