title: Alstiphyllanines A-D, indole alkaloids from Alstonia macrophylla.
abstract: Four new alkaloids, alstiphyllanines A-D (1-4), were isolated from Alstonia macrophylla, and their structures were determined by MS and 2D NMR analyses. Alkaloids 1-4 showed moderate antiplasmodial activity against Plasmodium falciparum and vasorelaxant activity against phenylephrine-induced contraction of isolated rat aorta.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa, Tokyo 142-8501, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Arai
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Rice
authors.initials: R
authors.lastname: Oktarina
authors.forename: Abdul
authors.initials: A
authors.lastname: Rahman
authors.forename: Wiwied
authors.initials: W
authors.lastname: Ekasari
authors.forename: Aty
authors.initials: A
authors.lastname: Widyawaruyanti
authors.forename: Gunawan
authors.initials: G
authors.lastname: Indrayanto
authors.forename: Noor Cholies
authors.initials: NC
authors.lastname: Zaini
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D031051:Alstonia / Q000737:chemistry*; D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001011:Aorta / Q000187:drug effects; D004727:Endothelium / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D015394:Molecular Structure; D009119:Muscle Contraction / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D010656:Phenylephrine / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D026121:Indole Alkaloids; D014665:Vasodilator Agents; D010656:Phenylephrine