title: Quantitative determination of dimethylaminoethanol in cosmetic formulations by nuclear magnetic resonance spectroscopy.
abstract: A nuclear magnetic resonance (NMR) spectroscopic method was validated for the quantitative determination of dimethylaminoethanol (DMAE) in cosmetic formulations. The linearity in the range from 0.5000 to 1.5000 g (DMAE salt/mass maleic acid) presents a correlation coefficient > 0.99 for all DMAE salts. The repeatability (intraday), expressed as relative standard deviation, ranged from 1.08 to 1.44% for samples and 1.31 to 1.88% for raw materials. The detection limit and quantitation limit were 0.0017 and 0.0051 g for DMAE, 0.0018 and 0.0054 g for DMAE bitartrate, and 0.0023 and 0.0071 g for DMAE acetamidobenzoate, respectively. The proposed method is simple, precise, and accurate and can be used in the quality control of raw materials and cosmetic gels containing these compounds as active substances.
authors.affiliation: University of São Paulo, Department of Pharmacy, Faculty of Pharmaceutical Sciences, CEP 05508-000, São Paulo-SP, Brazil.
authors.forename: Ivani Aparecida Soares de Andrade
authors.initials: IA
authors.lastname: Batista
authors.forename: Maria Inês de Almeida
authors.initials: MI
authors.lastname: Gonçalves
authors.forename: Anil Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Erika Rosa Maria Kedor
authors.initials: ER
authors.lastname: Hackmann
authors.forename: Maria Inês Rocha Miritello
authors.initials: MI
authors.lastname: Santoro
mesh_terms: D002626:Chemistry, Pharmaceutical; D003358:Cosmetics / Q000032:analysis*; D003642:Deanol / Q000032:analysis*; D005782:Gels / Q000032:analysis; D009682:Magnetic Resonance Spectroscopy; D011786:Quality Control; D015203:Reproducibility of Results; D012997:Solvents
chemical_list: D003358:Cosmetics; D005782:Gels; D012997:Solvents; D003642:Deanol