title: HLA-B*2709 and lack of susceptibility to sacroiliitis: further support from the clinic.
abstract: Interferons (IFN) are well known triggers of immunomediated diseases in genetically predisposed subjects. We describe the unique case of a HLA-B*2709 positive subject who underwent IFN-alpha treatment for essential thrombocythemia and developed arthritis of the proximal interphalangeal joints of the hands but not sacroiliitis. The possible mechanisms of IFN-induced arthritis are discussed.
authors.affiliation: Department of Rheumatology, University of Cagliari, Sardinia, Italy. cauli@pacs.unica.it
authors.forename: A
authors.initials: A
authors.lastname: Cauli
authors.forename: A
authors.initials: A
authors.lastname: Vacca
authors.forename: G
authors.initials: G
authors.lastname: Dessole
authors.forename: M T
authors.initials: MT
authors.lastname: Fiorillo
authors.forename: G
authors.initials: G
authors.lastname: Porru
authors.forename: V
authors.initials: V
authors.lastname: Ibba
authors.forename: V
authors.initials: V
authors.lastname: Mura
authors.forename: M
authors.initials: M
authors.lastname: Piga
authors.forename: R
authors.initials: R
authors.lastname: Sorrentino
authors.forename: A
authors.initials: A
authors.lastname: Mathieu
mesh_terms: D000328:Adult; D001168:Arthritis / Q000139:chemically induced* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects; D016898:Interferon-alpha / Q000009:adverse effects*; D012446:Sacroiliac Joint; D013167:Spondylitis, Ankylosing / Q000235:genetics; D013920:Thrombocythemia, Essential / Q000188:drug therapy* / Q000235:genetics
chemical_list: D015235:HLA-B Antigens; D007155:Immunologic Factors; D016898:Interferon-alpha