Diene-ligated iridium catalyst for allylation reactions of ketones and imines.
[Ir(cod)Cl](2) is a highly reactive catalyst for allylation reactions of ketones using allylboronic ester. Mechanistic experiments are consistent with formation of a nucleophilic allyliridium(I) complex that is activated by the diene ligand toward attack of a ketone. Aryl and alkyl ketones react smoothly at room temperature. Aldimines also undergo allylation under these reaction conditions, requiring increased reaction times relative to the corresponding ketones.
Barker
Timothy J
TJ
Natural Sciences I 4114, Department of Chemistry, University of California, Irvine, Irvine, California 92697, USA.
Jarvo
Elizabeth R
ER