Risk stratification of the patients with Brugada type electrocardiogram: a community-based prospective study.
OBJECTIVE
Risk stratification of patients with Brugada electrocardiogram (ECG) is being strongly debated. Conflicting results have been suggested from international registries, which enrolled non-consecutive cases, studied with different programmed electrical stimulation (PES) protocols. The aim of this study was to prospectively evaluate the incidence of arrhythmic events and the prognostic role of clinical presentation, ECG, and of a standardized PES protocol in consecutive cases from a community-based population.


RESULTS
A total of 166 consecutive patients (45 +/- 14 years) with Brugada ECG were enrolled. Type 1 ECG was observed spontaneously in 72 (43%) and after pharmacological testing in 94 (57%). One hundred and three (62%) were asymptomatic, 58 (35%) had syncope, and five (3%) had a prior cardiac arrest. One hundred and thirty-five (81%) underwent PES with two extra stimuli up to ventricular refractoriness and 34% had ventricular fibrillation (VF) induced. Arrhythmic events occurred in nine patients at a mean follow-up of 30 +/- 21 months (2.2 events per 100 person-year): in three (60%) patients with aborted sudden death (aSD), five (8.6%) of those with syncope, and one (1%) of the asymptomatic. The only predictors of events were a history of syncope or aSD (P = 0.02) and induction at PES (P = 0.004).


CONCLUSIONS
Clinical presentation is the most important parameter in the risk stratification of patients with Brugada ECG. Programmed electrical stimulation seems valuable, particularly in patients with previous syncope.
Giustetto
Carla
C
Division of Cardiology, Cardinal Massaia Hospital, University of Torino, Corso Dante, 202, 14100 Asti, Italy. carlagiustetto@mac.com
Drago
Stefano
S
Demarchi
Pier Giuseppe
PG
Dalmasso
Paola
P
Bianchi
Francesca
F
Masi
Andrea Sibona
AS
Carvalho
Paula
P
Occhetta
Eraldo
E
Rossetti
Guido
G
Riccardi
Riccardo
R
Bertona
Roberta
R
Gaita
Fiorenzo
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology; D053840:Brugada Syndrome / Q000150:complications* / Q000235:genetics / Q000628:therapy*; D002648:Child; D016757:Death, Sudden, Cardiac / Q000453:epidemiology*; D017147:Defibrillators, Implantable; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013575:Syncope / Q000209:etiology / Q000503:physiopathology; D016896:Treatment Outcome; D055815:Young Adult