[Cardiovascular disturbances in acromegaly].
Acromegaly causes a number of disorders in the cardiovascular system, resulting from chronic exposure to high levels of GH and IGF-1. Such disorders are the main responsible for increased mortality rates among acromegalic patients. Among several forms of cardiovascular impairment is acromegalic cardiomyopathy, an entity that is initially characterized by a hyperdynamic state, followed by concentric left ventricular hypertrophy and diastolic dysfunction due to relaxation deficit, culminating in systolic dysfunction and sometimes heart failure. In addition, arrhythmias and heart valve diseases are also relevant, especially mitral and aortic, ischemic heart disease, hypertension, and glucose and lipid metabolism disorders. This review approaches the main clinical and prognostic aspects of these entities, the effects of acromegaly treatment on them, and the respective consequences on patient survival.
Fedrizzi
Daniela
D
Unidade de Neuroendocrinologia, Serviço de Endocrinologia, Hospital de Clínicas de Porto Alegre. danifedrizzi@hotmail.com
Czepielewski
Mauro Antonio
MA
D000172:Acromegaly / Q000150:complications* / Q000378:metabolism / Q000628:therapy; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology; D006332:Cardiomegaly / Q000209:etiology; D005260:Female; D006331:Heart Diseases / Q000209:etiology*; D006349:Heart Valve Diseases / Q000209:etiology; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000209:etiology
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I