title: Changes of ROS during a two-day ultra-marathon race.
abstract: To assess oxidative stress (OS) induced by endurance exercise, concentrations of serum reactive oxygen species (ROS) were determined in 70 Japanese male amateur runners completing a two-day ultra-marathon race. Serum ROS levels were analyzed at three time points: before the race (baseline), after the 1st day race (mid-race), and after the 2nd day race (goal) (post-race). The means (SE) of ROS were 151.4(3.7) (U. CARR.), 168.7(4.4), and 156.8(4.4), respectively. Significant positive trends were noted between age and serum ROS concentrations at the three race points (p<0.05 for all). After adjusting for age, BMI and average monthly running distance, the baseline serum ROS concentrations were positively associated with completion times of the first-day race, in particular (p<0.05), suggesting that the concentrations may predict physical performance. The ROS production increased at mid-race (p<0.05), but the levels returned to baseline levels at post-race, indicating that an antioxidant defense system may develop post-race to reduce OS.
authors.affiliation: Nagoya City University Graduate School of Medical Sciences, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Hattori
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Nakachi
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
authors.forename: C
authors.initials: C
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Tokudome
authors.forename: K
authors.initials: K
authors.lastname: Kuriki
authors.forename: H
authors.initials: H
authors.lastname: Hoshino
authors.forename: K
authors.initials: K
authors.lastname: Shibata
authors.forename: N
authors.initials: N
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Tokudome
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Nagaya
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Tokudome
mesh_terms: D000328:Adult; D000367:Age Factors; D054874:Athletic Performance / Q000502:physiology; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010807:Physical Endurance / Q000502:physiology; D017382:Reactive Oxygen Species / Q000097:blood*; D012420:Running / Q000502:physiology*
chemical_list: D017382:Reactive Oxygen Species