Correcting aberrant kinetochore microtubule attachments: an Aurora B-centric view.
The directed movement of chromosomes during mitosis and meiosis relies on microtubule-mediated connections between spindle poles and kinetochores assembled on chromosomes. The molecular basis for the dynamic interaction between microtubules and kinetochores is just beginning to be unveiled. Here, focusing on the mitotic centromere kinase Aurora B, we review our current understanding of the signaling pathways that correct erroneous microtubule attachment at kinetochores. We evaluate several potential models that may explain how maloriented attachments are recognized and processed by the Aurora B pathway.
Kelly
Alexander E
AE
The Rockefeller University, Laboratory of Chromosome and Cell Biology, 1230 York Avenue, New York, NY 10065, USA.
Funabiki
Hironori
H
D000818:Animals; D064127:Aurora Kinases; D002503:Centromere / Q000378:metabolism*; D018386:Kinetochores / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D008954:Models, Biological; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*
D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases