Chronic obstructive pulmonary disease and interstitial lung disease in patients with lung cancer.
OBJECTIVE
Although lung cancer is frequently accompanied by COPD and interstitial lung disease (ILD), the precise coincidence of these diseases with lung cancer is not well understood. The objectives of this study were to determine the prevalence of abnormal CT and spirometric findings suggestive of COPD or ILD in a population of patients with untreated lung cancer, and to estimate the lung cancer risk in this population.


METHODS
The study population consisted of 256 patients with untreated lung cancer and 947 subjects participating in a CT screening programme for lung cancer. Semi-quantitative analysis of low attenuation area (LAA), fibrosis and ground glass attenuation (GGA) on CT was performed by scoring. Gender- and age-matched subpopulations, with stratification by smoking status, were compared using the Mantel-Haenszel projection method.


RESULTS
Inter-observer consistency was excellent for LAA, but not as good for fibrosis or GGA scores. Pooled odds ratios for lung cancer risk using LAA, fibrosis, GGA scores and reduced FEV(1)/FVC and %VC were 3.63, 5.10, 2.71, 7.17 and 4.73, respectively (P < 0.0001 for all parameters). Multivariate regression analyses confirmed these results.


CONCLUSIONS
Abnormal CT and spirometric parameters suggestive of COPD and ILD were strong risk factors for lung cancer, even after adjusting for gender, age and smoking status.
Mizuno
Satoko
S
Department of Respirology, Graduaet School of Medicine, Chiba University, Chiba, Japan.
Takiguchi
Yuichi
Y
Fujikawa
Ayako
A
Motoori
Ken
K
Tada
Yuji
Y
Kurosu
Katsushi
K
Sekine
Yasuo
Y
Yanagawa
Noriyuki
N
Hiroshima
Kenzo
K
Muraoka
Katsumi
K
Mitsushima
Toru
T
Niki
Noboru
N
Tanabe
Nobuhiro
N
Tatsumi
Koichiro
K
Kuriyama
Takayuki
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000503:physiopathology; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015588:Observer Variation; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013147:Spirometry; D014057:Tomography, X-Ray Computed