Evidence for Independently Regulated Secretory Pathways of Proopiomelano-cortin-Related Peptides in the Mouse Pars Intermedia.
The existence of multiple secretory pathways within endocrine cells has been receiving increasing attention (1-5). In some cases there is evidence for independently regulated pathways, for example in prolactin-producing cells (6) and parathyroid hormone-producing cells (7, 8). These pathways concern newly synthesized hormone versus hormone sequestered in mature secretory compartments. In the present study, we have analysed secretion of newly synthesized and mature peptides from proopiomelanocortin (POMC)-producing cells of the mouse pars intermedia. Evidence has been found for independent regulation and we show that the peptide composition of the two secretory pathways differs with respect to some of the POMC-derived peptides.
Leenders
H J
HJ
Department of Animal Physiology, University of Nijmegen, Toernooiveld, 6525 ED Nijmegen, The Netherlands.
Jenks
B G
BG
Rêlo
A L
AL
Roubos
E W
EW