title: Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection.
abstract: The in vivo efficacy of piperacillin in combination with the penem inhibitor BLI-489 was determined using acute lethal systemic infections in mice. On the basis of preliminary results with various ratios, a dosing ratio of 8:1 was found to be optimal for retention of enhanced efficacy. Piperacillin-BLI-489 dosed at an 8:1 ratio was efficacious against murine infections caused by class A (including extended-spectrum beta-lactamases), class C (AmpC), and class D beta-lactamase-expressing pathogens.
authors.affiliation: Infectious Disease Research, Wyeth Research, Pearl River, NY 10965, USA. petersp@wyeth.com
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Petersen
authors.forename: C Hal
authors.initials: CH
authors.lastname: Jones
authors.forename: Aranapakam M
authors.initials: AM
authors.lastname: Venkatesan
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Bradford
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000188:drug therapy*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005260:Female; D007769:Lactams / Q000008:administration & dosage*; D051379:Mice; D010878:Piperacillin / Q000008:administration & dosage*; D065093:beta-Lactamase Inhibitors
chemical_list: D000900:Anti-Bacterial Agents; C539934:BLI-489; D007769:Lactams; D065093:beta-Lactamase Inhibitors; D010878:Piperacillin