title: Hepatosplenic T-cell lymphomas and therapy with TNF-alpha-blocking biologics: a risk for psoriasis patients?
abstract: Tumor necrosis factor (TNF)-alpha antagonists have considerably improved the therapeutic approach to chronic inflammatory disorders including psoriasis vulgaris. Recently, some cases of highly aggressive hepatosplenic T-cell lymphoma (HSTCL) have developed in patients with inflammatory bowel diseases (IBD) being treated with infliximab or adalimumab. Analysis of the published data suggests that the emergence of HSTCL is favored by the combination of purine analogues and infliximab or adalimumab in the therapy of a granulomatous inflammation involving Vdelta1(+)gammadelta T cells. Because psoriasis vulgaris is different from IBD in regard to the type of inflammation, the concomitant therapies used and the tissue-specific subsets of gammadelta T cells, the use of infliximab or adalimumab in psoriasis may not necessarily be associated with an increase in the risk of HSTCL.
authors.affiliation: Department of Dermatology, Venerology and Allergology, Charité Universitätsmedizin Berlin, Berlin D-10117, Germany. marc.beyer@charite.de
authors.forename: Marc
authors.initials: M
authors.lastname: Beyer
authors.forename: Matthias
authors.initials: M
authors.lastname: Steinhoff
authors.forename: Ioannis
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: Chalid
authors.initials: C
authors.lastname: Assaf
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D006801:Humans; D016399:Lymphoma, T-Cell / Q000139:chemically induced*; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000893:Anti-Inflammatory Agents; D014409:Tumor Necrosis Factor-alpha