Total synthesis of amidepsine B and revision of its absolute configuration.
The total synthesis of (-)-amidepsine B, a potent diacylglycerol acyltransferase inhibitor, has been achieved. This synthetic study resulted in the revision of the previously assigned stereostructure of the natural amidepsine B and determined the absolute configuration.
Nagamitsu
Tohru
T
School of Pharmacy, Kitasato University, Minato-ku, Tokyo, Japan.
Marumoto
Kaori
K
Nagayasu
Asami
A
Fukuda
Takeo
T
Arima
Shiho
S
Uchida
Ryuji
R
Ohshiro
Taichi
T
Harigaya
Yoshihiro
Y
Tomoda
Hiroshi
H
Omura
Satoshi
S
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D051048:Diacylglycerol O-Acyltransferase / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D062385:Hydroxybenzoates / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004791:Enzyme Inhibitors; D062385:Hydroxybenzoates; D007202:Indicators and Reagents; C096618:amidepsine B; D051048:Diacylglycerol O-Acyltransferase