Segregation distortion at a microsatellite marker in the olive flounder, Paralichtys olivaceus.
In the course of quantitative trait loci (QTL) analysis of the back cross (BC1) families of olive flounder (Paralichtys olivaceus), we observed significant segregation distortion at a microsatellite marker Poli9-58TUF in two crosses of informative progenies. The family 1 of the random BC1 progenies derived from a cross between a F1 male genotype (A/B) and a F1's female parent genotype (A/C) and the family 2 (A/C x A/C) displayed a strong bias in the locus from the Mendelian inheritance by the elimination of homozygous A/A genotype. The deleterious roles of the AA genotypes are suggested during the metamorphosis and it implies that the parents of these families carried a recessive gene or genes hampering development at an early stage because the offspring of the double heterozygote parents show the reduction in frequency or elimination of one homozygous class, which is an evidence for linkage between the genetic marker and gene(s) with recessive deleterious alleles. This data support a hypothesis that the region contains a recessive lethal gene or genes.
Kang
Jung Ha
JH
Biotechnology Research Institute, National Fisheries Research and Development Institute, 619-902, Republic of Korea. jhkang@nfrdi.re.kr
Kim
Jong Hyun
JH
Kim
Hyun Chul
HC
Noh
Jae Koo
JK
Lee
Jeong Ho
JH
Kim
Kyung Kil
KK
D000483:Alleles; D000818:Animals; D020090:Chromosome Segregation / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D005432:Flounder / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D007178:Inbreeding; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics
D005819:Genetic Markers