title: Fluoroalkyl alpha side chain containing 3,4-diamino-cyclobutenediones as potent and orally bioavailable CXCR2-CXCR1 dual antagonists.
abstract: A series of potent and orally bioavailable 3,4-diaminocyclobutenediones with various fluoroalkyl groups as alpha side chain were prepared and found to show significant improvements in the binding affinities towards both CXCR2 and CXCR1 receptors.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
authors.forename: Purakkattle
authors.initials: P
authors.lastname: Biju
authors.forename: Arthur G
authors.initials: AG
authors.lastname: Taveras
authors.forename: Michael P
authors.initials: MP
authors.lastname: Dwyer
authors.forename: Younong
authors.initials: Y
authors.lastname: Yu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Chao
authors.forename: R William
authors.initials: RW
authors.lastname: Hipkin
authors.forename: Xuedong
authors.initials: X
authors.lastname: Fan
authors.forename: Diane
authors.initials: D
authors.lastname: Rindgen
authors.forename: Jay
authors.initials: J
authors.lastname: Fine
authors.forename: Daniel
authors.initials: D
authors.lastname: Lundell
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001665:Binding Sites; D003503:Cyclobutanes / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D023062:Receptors, Interleukin-8A / Q000037:antagonists & inhibitors* / Q000378:metabolism; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D003503:Cyclobutanes; D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B