Sjögren's syndrome with ANCA-associated crescentic extramembranous glomerulonephritis.
A 49-year-old woman with a 1-year history of Sjögren's syndrome was diagnosed with cutaneous leukocytoclastic vasculitis and necrotizing crescentic membranous glomerulonephritis. Antineutrophil cytoplasmic antibodies targeting myeloperoxidase were found. She reported a transient episode of nephritis 4 years earlier. This pattern of kidney disease is not typical of Sjögren's syndrome. Methylprednisolone boluses followed by oral glucocorticoid therapy were given in combination with mycophenolate mofetil. Renal function stabilized after 2 months, and tests for anti-myeloperoxidase reverted to negative.
Guillot
Xavier
X
Service de rhumatologie, CHU de POITIERS, Hôpital Jean Bernard, Avenue Jacques Coeur, 86000 Poitiers, France. xavier.guillot@yahoo.fr
Solau-Gervais
Elisabeth
E
Coulon
Alix
A
Debiais
Françoise
F
D000284:Administration, Oral; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D004359:Drug Therapy, Combination; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007275:Injections, Intravenous; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D009195:Peroxidase / Q000276:immunology; D012859:Sjogren's Syndrome / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D016896:Treatment Outcome; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D009195:Peroxidase; D009173:Mycophenolic Acid; D008775:Methylprednisolone