Re-emerging chloramphenicol sensitivity and emerging low level ciprofloxacin resistance among Salmonella enterica serotype typhi isolates in North India.
Ciprofloxacin has become the antibiotic of choice for the treatment of typhoid fever with the emergence and worldwide spread of Salmonella enterica typhi strains resistant to chloramphenicol. However, the rampant use of ciprofloxacin gradually led to an increase in its minimum inhibitory concentration against S. enterica typhi. This threatened its therapeutic efficacy and resulted in the re-emergence of chloramphenicol-sensitive S. enterica typhi strains.
Gupta
Varsha
V
Department of Microbiology, Government Medical College & Hospital Sec-32, Chandigarh, Punjab 160030, India. varshagupta_99@yahoo.com
Kaur
Jaspal
J
Kaistha
Neelam
N
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology* / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000494:pharmacology* / Q000627:therapeutic use; D024881:Drug Resistance, Bacterial; D006801:Humans; D007194:India; D008826:Microbial Sensitivity Tests; D012485:Salmonella typhi / Q000187:drug effects* / Q000302:isolation & purification; D014435:Typhoid Fever / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin; D002701:Chloramphenicol