Laser therapy converts diabetic wound healing to normal healing.
OBJECTIVE
We have determined optimal laser dosimetric parameters in comparison with polychromatic light-emitting diodes (LEDs) that can speed up healing in four animal models: non-diabetic oval full-thickness wounds, diabetic oval full-thickness wounds, non-diabetic burns, and diabetic burns in Sprague-Dawley rats.


METHODS
This series of studies used 532-, 633-, 810-, 980-, and 10,600-nm lasers (visible to far infrared) and polychromatic LED clusters (510-872 nm, visible to infrared) as photon sources. Sprague-Dawley rats (n = 893) were used; however, animals that died before and during the experiments from anesthesia accidents and for any other reason were excluded from statistical analysis.


RESULTS
The improvements seen (>10% improvement of impairment) show that phototherapy with the 633-nm laser is quite promising for alleviating diabetic wound and burn healing, and exhibited the best results with 38.5% and 53.4% improvements, respectively.


CONCLUSIONS
In this induced-diabetes model, wound and burn healing were improved by 40.3% and 45%, respectively, in 633-nm laser dosimetry experiments, and diabetic wound and burn healing was accelerated by phototherapy. This indicates that the healing rate was normalized in the phototherapy-treated diabetic rats. In view of these interesting findings, 633-nm laser therapy given three times per week at 4.71 J/cm(2) per dose for diabetic burns, and three times per week at 2.35 J/cm(2) per dose for diabetic wound healing are recommended as actual doses for human clinical trials, especially after major surgery in those with impaired healing, such as diabetics and the elderly.
Al-Watban
Farouk A H
FA
Laser Medicine Research Section, Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia. Watban@kfshrc.edu.sa
D000818:Animals; D002056:Burns / Q000473:pathology / Q000532:radiotherapy*; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D028022:Low-Level Light Therapy; D011879:Radiotherapy Dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing / Q000528:radiation effects*