Synthesis of (E)- and (Z)-alpha,beta-Difluorourocanic Acid.
Horner-Emmons fluoroolefination of an aryl aldehyde followed by introduction of a second fluorine via "FBr" addition provides an original approach to the preparation of 1-alkyl-2-aryl-1,2-difluoroethenes. The utility of this procedure is demonstrated by the preparation of (E and Z)-alpha,beta-difluorourocanic acid.
Hajduch
Jan
J
Laboratory of Bioorganic Chemistry, National Institute of Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Dolenský
Bohumil
B
Yoshida
Shinichi
S
Fan
Junfa
J
Kirk
Kenneth L
KL