title: Lack of association between interleukin-1a gene (IL-1a) C (-889) T variant and polycystic ovary syndrome in Chinese women.
abstract: Polycystic ovary syndrome (PCOS) is associated with the spontaneous development of an aberrant heterogeneous hormonal environment that thought to be related to multiple genetic or environmental factors remain undefined. Previous studies indicated that IL-1a gene C (-889) T, a polymorphism of the gene encoding a protein which involved in various immune responses, inflammatory processes and hematopoiesis, and is associated with PCOS. A total of 205 PCOS patients and 177 healthy controls were included in this study that used PCR-RFLP to detect C (-889) T variant of IL-1a gene. Clinical measures determined previously were included in the SPSS analysis. The results showed that the presence of IL-1a gene C (-889) T polymorphism in PCOS and healthy controls in Chinese women was not significantly different when studying genotype and allele frequencies. (Genotype: chi(2) = 4.62, df = 2, P = 0.10; allele: chi(2) = 1.35, df = 1, P = 0.25). Furthermore, no association was found between metabolic parameters observed and IL-1a genotypes in PCOS patients in this study. In conclusion, IL-1a gene C (-889) T polymorphism does not appear to be risk factor for PCOS in this population of Chinese women.
authors.affiliation: Center for Genetics, National Research Institute for Family Planning, 12, Dahuisi Road, Haidian, Beijing 100081, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Sirui
authors.initials: S
authors.lastname: Zhou
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jingjing
authors.initials: J
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Ni
authors.forename: Chunmei
authors.initials: C
authors.lastname: Liu
authors.forename: Jinting
authors.initials: J
authors.lastname: Yan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Mu
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000328:Adult; D002681:China; D004247:DNA / Q000032:analysis; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D007986:Luteinizing Hormone / Q000097:blood; D009765:Obesity / Q000235:genetics; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood
chemical_list: D053582:Interleukin-1alpha; D013739:Testosterone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004247:DNA