title: [Crohn's disease during the course of multiple sclerosis: role of interferon-beta therapy].
abstract: Interferon-beta (IFN-beta) therapy can trigger immune adverse effects. We report a patient, who was treated for multiple sclerosis (MS) by IFN-beta during 3 years before developing a severe colitis due to Crohn's disease (CD). Neurological manifestations may occur in CD but rarely mimic MS. This report's points highlight the possible association of MS and CD, where IFN-beta therapy probably unmasked CD. Indeed, similar cases of CD flares have been reported after IFN-alpha therapy for chronic C hepatitis.
authors.affiliation: Service de médecine interne et maladies systémiques, CHU de Dijon, hôpital Général, 3, rue du Faubourg-Raines, 21000 Dijon, France. samsonmaxime@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Samson
authors.forename: S
authors.initials: S
authors.lastname: Audia
authors.forename: C
authors.initials: C
authors.lastname: Duchêne
authors.forename: I
authors.initials: I
authors.lastname: Perinet
authors.forename: P
authors.initials: P
authors.lastname: Bielefeld
authors.forename: J-F
authors.initials: JF
authors.lastname: Besancenot
mesh_terms: D003424:Crohn Disease / Q000139:chemically induced* / Q000175:diagnosis; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D007279:Injections, Subcutaneous; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D007155:Immunologic Factors; D016899:Interferon-beta