title: [Morphological and laminar distribution of cholecystokinin-immunoreactive neurons in cortex of human inferior parietal lobe and their clinical significance].
abstract: BACKGROUND
  Cholecystocinine is a neuropeptide whose function in the cortex has not yet been clarified, although its relation with some psychic disorders has been noticed. Previous studies have not provided detailed data about types, or arrangement of neurons that contain those neuropeptide in the cortex of human inferior parietal lobe. The aim of this study was to examine precisely the morphology and typography of neurons containing cholecytocinine in the human cortex of inferior parietal lobule.
  
  
  METHODS
  There were five human brains on which we did the immunocystochemical research of the shape and laminar distribution of cholecystocinine immunoreactive neurons on serial sections of supramarginal gyrus and angular gyrus. The morphological analysis of cholecystocinine-immunoreactive neurons was done on frozen sections using avidin-biotin technique, by antibody to cholecystocinine diluted in the proportion 1:6000 using diamine-benzedine.
  
  
  RESULTS
  Cholecystocinine immunoreactive neurons were found in the first three layers of the cortex of inferior parietal lobule, and their densest concentration was in the 2nd and 3rd layer. The following types of neurons were found: bipolar neurons, then its fusiform subtype, Cajal-Retzius neurons (in the 1st layer), reverse pyramidal (triangular) and unipolar neurons. The diameters of some types of neurons were from 15 to 35 microm, and the diameters of dendritic arborization were from 85-207 microm. A special emphasis is put on the finding of Cajal-Retzius neurons that are immunoreactive to cholecystocinine, which demands further research.
  
  
  CONCLUSIONS
  Bearing in mind numerous clinical studies pointing out the role of cholecystokinine in the pathogenesis of schizophrenia, the presence of a great number of cholecystokinine immunoreactive neurons in the cortex of inferior parietal lobule suggests their role in the pathogenesis of schizophrenia.
authors.affiliation: Anatomski institut, Medicinski fakultet Beograd. puskas@dr.com
authors.forename: Laslo
authors.initials: L
authors.lastname: Puskas
authors.forename: Saveta
authors.initials: S
authors.lastname: Draganić-Gajić
authors.forename: Slobodan
authors.initials: S
authors.lastname: Malobabić
authors.forename: Nela
authors.initials: N
authors.lastname: Puskas
authors.forename: Dragan
authors.initials: D
authors.lastname: Krivokuća
authors.forename: Gordana
authors.initials: G
authors.lastname: Stanković
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D002766:Cholecystokinin / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry* / Q000166:cytology; D009479:Neuropeptides / Q000032:analysis*; D010296:Parietal Lobe / Q000737:chemistry*
chemical_list: D009479:Neuropeptides; D002766:Cholecystokinin