[Pelvic perfusion for localy advanced tumors].
Isolated pelvic perfusion (IPP) is a method of intra-arterial local-regional treatment using a simplified balloon occlusion technique. It achieved high-dose drug concentration in pelvis with the minimal adverse effects. Recently, this approach was improved with the use of a pressure-suit placed above the level of aortic and caval stop-flow. A better ratio between pelvic and systemic compartments was achieved. This stop-flow technique with low dose TNF-alpha and melphalan has shown promise in palliation of resectability of advanced cancer in patients not amenable to treatment with conventional chemo radiation in a comparable proportion to those obtained with isolated limb perfusions. A randomized study will start soon.
Bonvalot
Sylvie
S
Département de chirurgie, Institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif. bonvalot@igr.fr
Muret
Jane
J
Debaere
Thierry
T
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002417:Cattle; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000379:methods*; D017326:Clinical Trials, Phase III as Topic; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D008558:Melphalan / Q000008:administration & dosage*; D010386:Pelvic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage*
D000970:Antineoplastic Agents; D014409:Tumor Necrosis Factor-alpha; D008558:Melphalan