Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
Trégouët
David-Alexandre
DA
Institut National de la Santé Et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR_S) 525, Université Pierre et Marie Curie (UPMC). Paris 06, Paris 75013, France. david.tregouet@upmc.fr
König
Inke R
IR
Erdmann
Jeanette
J
Munteanu
Alexandru
A
Braund
Peter S
PS
Hall
Alistair S
AS
Grosshennig
Anika
A
Linsel-Nitschke
Patrick
P
Perret
Claire
C
DeSuremain
Maylis
M
Meitinger
Thomas
T
Wright
Ben J
BJ
Preuss
Michael
M
Balmforth
Anthony J
AJ
Ball
Stephen G
SG
Meisinger
Christa
C
Germain
Cécile
C
Evans
Alun
A
Arveiler
Dominique
D
Luc
Gérald
G
Ruidavets
Jean-Bernard
JB
Morrison
Caroline
C
van der Harst
Pim
P
Schreiber
Stefan
S
Neureuther
Katharina
K
Schäfer
Arne
A
Bugert
Peter
P
El Mokhtari
Nour E
NE
Schrezenmeir
Jürgen
J
Stark
Klaus
K
Rubin
Diana
D
Wichmann
H-Erich
HE
Hengstenberg
Christian
C
Ouwehand
Willem
W
Ziegler
Andreas
A
Tiret
Laurence
L
Thompson
John R
JR
Cambien
Francois
F
Schunkert
Heribert
H
Samani
Nilesh J
NJ
D016633:Apolipoprotein A-II / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D017270:Lipoprotein(a) / Q000235:genetics*; D005810:Multigene Family; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012307:Risk Factors; D000099254:Organic Cation Transporter 3
D016633:Apolipoprotein A-II; D017270:Lipoprotein(a); D027701:Organic Cation Transport Proteins; D000099254:Organic Cation Transporter 3; C115794:APOA2 protein, human