Neopyrrolomycins with broad spectrum antibacterial activity.
Three new antibiotics, neopyrrolomycins B (1), C (2), and D (3), with potent activity against Gram-positive pathogens were discovered. They exhibited MIC values < 1 microg/mL versus a number of resistant strains. The compounds were obtained from the ethyl acetate extracts of a Streptomyces sp. after purification by column chromatography and RP-HPLC. Their structures were elucidated using X-ray crystallography (1) and NMR spectroscopy (2 and 3).
Hopp
D Craig
DC
AMRI, Bothell Research Center, 18804 North Creek Parkway, Bothell, Washington 98011, USA.
Rhea
Joshua
J
Jacobsen
Daniel
D
Romari
Khadidja
K
Smith
Chris
C
Rabenstein
John
J
Irigoyen
Macarena
M
Clarke
Midori
M
Francis
Linda
L
Luche
Michele
M
Carr
Grant J
GJ
Mocek
Ulla
U
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D016984:Enterococcus faecium / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*; D014640:Vancomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D011758:Pyrroles; C550398:neopyrrolomycin B; C550399:neopyrrolomycin C; C066136:neopyrrolomycin; D014640:Vancomycin