title: Efficacy of etravirine for treatment of acute HIV meningoencephalitis.
abstract: We describe a patient with human immunodeficiency virus (HIV) and hepatitis C virus coinfection who experienced recurrent episodes of acute HIV meningoencephalitis. The addition of etravirine to the therapeutic regimen completely resolved symptoms, and HIV was no longer detected in cerebrospinal spinal fluid specimens. Etravirine has a satisfactory safety profile and, in this case, was a durable alternative therapy for HIV meningoencephalitis.
authors.affiliation: Services des Maladies Infectieuses et Tropicales and Virologie, Assistance Publique-Hôpital de Paris, Hôpital Paul Brousse, Villejuif, France. couzigou@yahoo.fr)
authors.forename: Carine
authors.initials: C
authors.lastname: Couzigou
authors.forename: Sophie
authors.initials: S
authors.lastname: Seang
authors.forename: Laurence
authors.initials: L
authors.lastname: Morand-Joubert
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Roque-Afonso
authors.forename: Lélia
authors.initials: L
authors.lastname: Escaut
authors.forename: Daniel
authors.initials: D
authors.lastname: Vittecoq
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D002555:Cerebrospinal Fluid / Q000821:virology; D005260:Female; D006678:HIV / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy*; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008590:Meningoencephalitis / Q000188:drug therapy*; D009570:Nitriles; D011724:Pyridazines / Q000627:therapeutic use*; D011743:Pyrimidines; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; C451734:etravirine