title: Reinforcing suppression using regulators: a new link between STAT3, IL-23, and Tregs in tumor immunosuppression.
abstract: STAT3 plays many roles in tumorigenesis. In this issue of Cancer Cell, Kortylewski et al. show that in the tumor microenvironment, STAT3 enhances the expression of the protumor cytokine IL-23 in macrophages but inhibits the antitumor cytokine IL-12 in dendritic cells. STAT3 also mediates IL-23's effect of activating tumor-infiltrating regulatory T cells.
authors.affiliation: Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702-1201, USA.
authors.forename: C Andrew
authors.initials: CA
authors.lastname: Stewart
authors.forename: Giorgio
authors.initials: G
authors.lastname: Trinchieri
mesh_terms: D000818:Animals; D007165:Immunosuppression Therapy; D018664:Interleukin-12 / Q000276:immunology; D053759:Interleukin-23 / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D009369:Neoplasms / Q000276:immunology*; D050796:STAT3 Transcription Factor / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D053759:Interleukin-23; D050796:STAT3 Transcription Factor; D018664:Interleukin-12