Deadly splicing: Bax becomes Almighty.
Activation of Bax and Bak by BH3-only molecules triggers mitochondrial apoptosis. In a recent issue of Molecular Cell, Fu et al. (2009) identify a constitutively active isoform of Bax, Baxbeta, whose activity is tightly controlled by the ubiquitin-proteasome system.
Kim
Hyungjin
H
Molecular Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Hsieh
James J-D
JJ
Cheng
Emily H-Y
EH
D017398:Alternative Splicing / Q000502:physiology*; D017209:Apoptosis; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism*
D020033:Protein Isoforms; D014452:Ubiquitins; D051028:bcl-2-Associated X Protein; D046988:Proteasome Endopeptidase Complex