title: Effects of zinc on intestinal injury and some serum parameters in ethanol-administered rats.
abstract: This study was designed to determine the morphological and biochemical effects of zinc sulfate and the role of metallothionein in ethanol-induced intestinal injury. Rats received zinc sulfate (100 mg/kg/d) for 3 consecutive d, 2 h prior to the administration of ethanol by gavage. Ethanol administration caused intestinal injury as determined by increased serum lactate dehydrogenase activity, urea, creatinine, uric acid, and sialic acid levels, intestinal lipid peroxidation level, decreased serum catalase activity, intestinal glutathione level, and metallothionein expression. Zinc sulfate pretreatment of the ethanol group caused a decrease in histological damage, serum lactate dehydrogenase activity, urea, creatinine, uric acid, sialic acid levels, and intestinal lipid peroxidation level, but increases in serum catalase activity, intestinal glutathione level, and metallothionein expression. The present study indicates that zinc sulfate has a protective effect against ethanol-induced intestinal injury. In addition, the protective effect of zinc on ethanol-induced intestinal injury might be mediated by metallothionein, as well as having antioxidative potential.
authors.affiliation: Department of Biology, Faculty of Science, Istanbul University, Vezneciler, Turkey.
authors.forename: Pelin
authors.initials: P
authors.lastname: Arda-Pirincci
authors.forename: Bahar
authors.initials: B
authors.lastname: Bilgin-Sokmen
authors.forename: Refiye
authors.initials: R
authors.lastname: Yanardag
authors.forename: Sehnaz
authors.initials: S
authors.lastname: Bolkent
mesh_terms: D000818:Animals; D002374:Catalase / Q000097:blood / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage* / Q000633:toxicity*; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects* / Q000293:injuries*; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D044967:Serum / Q000201:enzymology / Q000378:metabolism*; D019287:Zinc Sulfate / Q000494:pharmacology*
chemical_list: D000431:Ethanol; D019287:Zinc Sulfate; D008668:Metallothionein; D007770:L-Lactate Dehydrogenase; D002374:Catalase