Spontaneous remission of a non-small cell lung cancer possibly caused by anti-NY-ESO-1 immunity.
Spontaneous remission of malignant tumors is rare and the biological mechanism of such remission has not been addressed. We report the case of a 71-year-old Japanese patient with non-small cell lung cancer with a right hilar tumor and pleural dissemination that spontaneously regressed. NY-ESO-1 is a cancer/testis antigen that can elicit specific immune responses in patients with cancer. Strong anti-NY-ESO-1 immunity was detected in this patient. His tumor cells expressed NY-ESO-1 and MHC class I molecules. Anti-NY-ESO-1 immunity might have contributed to spontaneous remission in this patient.
Nakamura
Yoichi
Y
Second Department of Internal Medicine, Nagasaki University School of Medicine, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan. yi-nakamu@umin.ac.jp
Noguchi
Yuji
Y
Satoh
Eiichi
E
Uenaka
Akiko
A
Sato
Shuichiro
S
Kitazaki
Takeshi
T
Kanda
Tetsuro
T
Soda
Hiroshi
H
Nakayama
Eiichi
E
Kohno
Shigeru
S
D000368:Aged; D000951:Antigens, Neoplasm / Q000276:immunology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000276:immunology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D009365:Neoplasm Regression, Spontaneous; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; C104948:CTAG1B protein, human; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit; D008565:Membrane Proteins