Efficient synthesis of sugar oxazolines from unprotected N-acetyl-2-amino sugars by using chloroformamidinium reagent in water.
Sugar oxazoline derivatives were directly synthesized from the corresponding N-acetyl-2-amino sugars in aqueous media by using a chloroformamidinium-type dehydrating reagent. The present method could successfully be applied to chito-oligosaccharides, saccharides with acid functions, and a complex-type oligosaccharide derived from a glycopeptide.
Noguchi
Masato
M
Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 6-6-11-514 Aoba, Aramaki Aobaku, Sendai, Japan.
Tanaka
Tomonari
T
Gyakushi
Hidetoshi
H
Kobayashi
Atsushi
A
Shoda
Shin-ichiro
S
D002241:Carbohydrates / Q000737:chemistry*; D005559:Formamides / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D002241:Carbohydrates; D005559:Formamides; D010080:Oxazoles; D014867:Water