D-serine, a selective glycine/N-methyl-D-aspartate receptor agonist, antagonizes the antidepressant-like effects of magnesium and zinc in mice.
Zinc and magnesium are potent inhibitors of the N-methyl-D-aspartate (NMDA) receptor complex. Recent data demonstrate that both zinc and magnesium, like other NMDA receptor antagonists, exhibit antidepressant-like activity in rodent screening tests and depression models. In the present study, we investigated the effect of D-serine (agonist for the glycine(B) site of the NMDA receptor complex; 100 nmol/mouse, icv) on magnesium (30 mg/kg, ip)- and zinc (5 mg/kg, ip)-induced activity during a forced swim test (FST) in mice. The antidepressant-like effect observed during FST for both ions was abolished by D-serine co-treatment. The present study indicates that the NMDA receptor complex, especially the glycine(B) site, plays a role in the antidepressant-like activity of magnesium and zinc in the FST in mice.
Poleszak
Ewa
E
Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Staszica 4, PL 20-081 Lublin, Poland.
Szewczyk
Bernadeta
B
Wlaź
Aleksandra
A
Fidecka
Sylwia
S
Wlaź
Piotr
P
Pilc
Andrzej
A
Nowak
Gabriel
G
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D008274:Magnesium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D018009:Receptors, Glycine / Q000819:agonists* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists* / Q000502:physiology; D012694:Serine / Q000494:pharmacology*; D015032:Zinc / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D000928:Antidepressive Agents; D018009:Receptors, Glycine; D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine; D008274:Magnesium; D015032:Zinc