title: Synthesis and in vitro antitubercular activity of a series of quinoline derivatives.
abstract: A series of 33 quinoline derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H(37)Rv using the Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory concentration (MIC) in microg/mL. Compounds 5e and 5f exhibited a significant activity at 6.25 and 3.12 microg/mL, respectively, when compared with first line drugs such as ethambutol and could be a good starting point to develop new lead compounds in the fight against multi-drug resistant tuberculosis.
authors.affiliation: FioCruz-Fundação Oswaldo Cruz, Instituto de Tecnologia em Fármacos-Far Manguinhos, Manguinhos, Rio de Janeiro, Brazil. marcos_souza@far.fiocruz.br
authors.forename: Marcus V N
authors.initials: MV
authors.lastname: de Souza
authors.forename: Karla C
authors.initials: KC
authors.lastname: Pais
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Kaiser
authors.forename: Mônica A
authors.initials: MA
authors.lastname: Peralta
authors.forename: Marcelle
authors.initials: M
authors.lastname: de L Ferreira
authors.forename: Maria C S
authors.initials: MC
authors.lastname: Lourenço
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D018088:Tuberculosis, Multidrug-Resistant
chemical_list: D000995:Antitubercular Agents; D011804:Quinolines