title: Synthesis of the beta-1,3-glucan, laminarahexaose: NMR and conformational studies.
abstract: The synthesis of laminarahexaose is described. NMR studies of several of the intermediates leading to the beta-1,3-glucan show anomalously small coupling constants for some of the C-1 hydrogens. An X-ray structure for the protected hexasaccharide shows that the small coupling constants are due to some of the glucopyranose rings adopting a twist-boat conformation. The X-ray studies also explain other unexpected NMR observations.
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, LA 70118, USA.
authors.forename: Kai-For
authors.initials: KF
authors.lastname: Mo
authors.forename: Huiqing
authors.initials: H
authors.lastname: Li
authors.forename: Joel T
authors.initials: JT
authors.lastname: Mague
authors.forename: Harry E
authors.initials: HE
authors.lastname: Ensley
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008958:Models, Molecular; D015394:Molecular Structure; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D047071:beta-Glucans / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D009844:Oligosaccharides; D047071:beta-Glucans; C086571:laminarihexaose; C033363:beta-1,3-glucan