title: [A case of fulminant meningococcal sepsis with an extreme inflammatory response].
abstract: Presented is a case of a 14-year-old-girl who succumbed to meningococcal infection within 9 hours after the first symptoms appeared and following 4-hour hospitalization. In the serum sample collected on admission, extremely high concentrations of interleukin 6 (IL-6), IL-8, IL-10 and endotoxin were found. Although cerebrospinal fluid (CSF) examination excluded concurrent meningitis, CSF cytokine concentrations were rather high as well; by contrast, endotoxin was not detected in the CSF. Despite intensive care provided at the department of anaesthesiology and resuscitation, which comprised antibiotic and corticosteroid therapy, mechanical ventilationand circulatory support, the girl died on the same day, due to irreversible circulatory and respiratory failure.
authors.affiliation: Dept. Infectious Diseases, 1st Med. Faculty, Charles University Prague, Czech Republic. michal.holub@lf1.cuni.cz
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Blechová
authors.forename: Michal
authors.initials: M
authors.lastname: Holub
mesh_terms: D000293:Adolescent; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008585:Meningitis, Meningococcal / Q000150:complications / Q000175:diagnosis