Effects of laser on the synovial fluid in the inflammatory process of the knee joint of the rabbit.
OBJECTIVE
The purpose of this study was to evaluate the effects of low-level laser (LLL) energy on the clinical signs of inflammation and the cellular composition of synovial fluid (SF) in the inflamed knee of the rabbit.


BACKGROUND
There are few findings related to the effects of LLL on SF in inflammatory processes and there is little knowledge about the optimal parameters for reducing joint inflammation.


METHODS
Inflammation in the right knee of 36 rabbits was induced by intracapsular injection (0.2 mL) of Terebinthina commun (Tc). The animals were randomly assigned to three groups: acute experimental group (AEG), chronic experimental group (CEG), and control group (CG), which only received Tc. Each group was divided in two subgroups of six animals each. The AEG and CEG groups began to receive laser treatment 2 and 5 d after the induction of inflammation, respectively. Laser irradiation at a wavelength of 830 nm, power output of 77 mW, and power density of 27.5 W/cm(2) was applied daily for 7 d for either 0.12 sec or 0.32 sec, resulting in doses of 3.4 J/cm(2) and 8 J/cm(2), respectively. Body mass, joint perimeter, joint temperature, and the morphology of the SF were analyzed.


RESULTS
There was no statistically significant differences between groups in the body mass, joint perimeter, and SF morphology.


CONCLUSIONS
Laser irradiation with the selected parameters produced only a few subtle differences in the inflammatory signs and the SF. The lack of effects may have been due to the short irradiation time.
Sandoval
Maria Christina
MC
School of Physical Therapy, Industrial University of Santander, Bucaramanga, Columbia. sandoval@uis.edu.co
Mattiello-Rosa
Stella Márcia Gonçalves
SM
Soares
Edson García
EG
Parizotto
Nivaldo Antonio
NA
D000818:Animals; D001168:Arthritis / Q000503:physiopathology / Q000532:radiotherapy*; D007719:Knee Joint / Q000528:radiation effects*; D054023:Lasers, Semiconductor; D028022:Low-Level Light Therapy; D008297:Male; D011817:Rabbits; D013582:Synovial Fluid / Q000528:radiation effects*