Antifungal triterpene glycosides from the sea cucumber Holothuria (Microthele) axiloga.
Three new holostan-type triterpene glycosides, arguside F (1), impatienside B (2), and pervicoside D (3), together with a known saponin, holothurin B ( 4) were isolated from the sea cucumber Holothuria (Microthele) axiloga H. L. Clark. On the basis of spectroscopic data and chemical reactions, the structures of the new compounds were elucidated. Compound 2 showed significant antifungal activities against six strains (1 < or = MIC(80) < or = 4 microg/mL). The stereochemistry of holothurin B (4) isolated from the title sea cucumber was also solved through X-ray diffraction analysis.
Yuan
Wei-Hua
WH
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, PR China.
Yi
Yang-Hua
YH
Tan
Ren-Xiang
RX
Wang
Zeng-Lei
ZL
Sun
Guo-Quan
GQ
Xue
Mei
M
Zhang
Hong-Wei
HW
Tang
Hai-Feng
HF
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047332:Holothuria / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000935:Antifungal Agents; D006027:Glycosides; D014315:Triterpenes; C544500:arguside F; C544499:impatienside B; C544498:pervicoside D