Insulin receptors and glucose uptake in the human parasite Schistosoma mansoni.
Very little is known about insulin signalling in schistosomes despite its potential importance in host-parasite molecular dialogue and parasite growth and development. The recent characterization of two insulin receptors (SmIR-1 and SmIR-2) in Schistosoma mansoni has led us to reconsider the question of the potential importance of insulin in host-schistosome interactions. In this work, we demonstrated that insulin could regulate glucose uptake in schistosomes and we investigated the implication of SmIR-1 and SmIR-2 in this process. The possibility that specific inhibitors of SmIR-1 and SmIR-2 tyrosine kinase activities could be developed to target schistosomes is discussed.
Ahier
A
A
Inserm U547, Lille, Université Lille 2, Institut Pasteur de Lille, IFR142, Lille, France.
Khayath
N
N
Vicogne
J
J
Dissous
C
C
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001700:Biomphalaria / Q000469:parasitology; D006224:Cricetinae; D005947:Glucose / Q000378:metabolism*; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008647:Mesocricetus; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D034622:RNA Interference; D011972:Receptor, Insulin / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000378:metabolism*; D012555:Schistosomiasis mansoni / Q000378:metabolism / Q000469:parasitology*; D016415:Sequence Alignment
D007328:Insulin; D000255:Adenosine Triphosphate; D011505:Protein-Tyrosine Kinases; D011972:Receptor, Insulin; D005947:Glucose