Synthesis, characterization, biological activities of dimethyltin(IV) complexes of Schiff bases with ONO-type donors.
Four different dimethyltin(IV) complexes of Schiff bases derived from 2-amino-3-hydroxypyridine and different substituted salicylaldehydes have been synthesized. The compounds, with the general formula [Me(2)Sn(2-OArCH=NC(5)H(3)NO)], where Ar=-C(6)H(3)(5-CH(3)) [Me(2)SnL(1)], -C(6)H(3)(5-NO(2)) [Me(2)SnL(2)], -C(6)H(2)(3,5-Cl(2)) [Me(2)SnL(3)], and -C(6)H(2)(3,5-I(2)) [Me(2)SnL(4)], were characterized by IR, NMR ((1)H and (13)C), mass spectroscopy and elemental analysis. Me(2)SnL(3) was also characterized by X-ray diffraction analysis and shows a fivefold C(2)NO(2) coordination with distorted square pyramidal geometry. H(3)C-Sn-CH(3) angles in the complexes were calculated using Lockhart's equations with the (1)J((117/119)Sn-(13)C) and (2)J((117/119)Sn-(1)H) values (from the (1)H-NMR and (13)C-NMR spectra). The in vitro antibacterial and antifungal activities of dimethyltin(IV) complexes were also investigated.
Oztaş
Nurşen Altuntaş
NA
Department of Chemistry, Faculty of Science, Hacettepe University, 06800, Ankara, Turkey.
Yenişehirli
Gülgün
G
Ancin
Nilgün
N
Oztaş
Selma Gül
SG
Ozcan
Yusuf
Y
Ide
Semra
S
D000447:Aldehydes / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D011725:Pyridines / Q000737:chemistry; D012545:Schiff Bases / Q000737:chemistry*; D014961:X-Ray Diffraction
D000447:Aldehydes; D009947:Organotin Compounds; D011725:Pyridines; D012545:Schiff Bases; C014047:hydroxypyridines; C013243:salicylaldehyde; C039760:dimethyltin