Botulinum toxin prevents radiotherapy-induced salivary gland damage.
Radiotherapy of head and neck malignancies results in severe damage to salivary glands. Irradiation-induced sialadenitis with xerostomia leads to a significant deterioration of the quality of life which lasts life-long. Here we show in a preliminary study that intraglandular application of botulinum toxin performed prior to radiation reduces significantly the radiation induced toxicity of the glandular tissue in rats.
Teymoortash
Afshin
A
Department of Otolaryngology, Head and Neck Surgery, Philipp University, Marburg, Germany. teymoort@med.uni-marburg.de
Müller
Felix
F
Juricko
Janko
J
Bieker
Michael
M
Mandic
Robert
R
Librizzi
Damiano
D
Höffken
Helmut
H
Pfestroff
Andeas
A
Werner
Jochen Alfred
JA
D000818:Animals; D018726:Anti-Dyskinesia Agents / Q000627:therapeutic use; D001905:Botulinum Toxins / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D051381:Rats; D017208:Rats, Wistar; D012793:Sialadenitis / Q000517:prevention & control*; D013363:Submandibular Gland / Q000000981:diagnostic imaging / Q000528:radiation effects*
D018726:Anti-Dyskinesia Agents; D011837:Radiation-Protective Agents; D001905:Botulinum Toxins