Pinpointing prognostic indicators of fungal infections in transplant patients.
A number of advances have been made in the prevention and treatment of invasive fungal infections (IFIs) in transplant recipients. However, despite best clinical efforts, patient outcomes are often disappointing. The study of prognostic indicators of IFI for transplant patients may aid in the development of improved prevention measures, or determine more aggressive treatment pathways. Owing to the rarity of IFI, appropriately powered studies are often difficult to achieve; moreover, a lack of standardized outcome definitions make study comparisons difficult. Herein, prognostic indicators for mortality in transplant patients with IFI are reviewed, with a focus on invasive aspergillosis and invasive candidiasis.
Baddley
John W
JW
University of Alabama at Birmingham, Birmingham, AL, USA. jbaddley@uab.ed
D001228:Aspergillosis / Q000401:mortality; D002177:Candidiasis / Q000401:mortality; D016469:Fungemia / Q000401:mortality*; D006801:Humans; D009181:Mycoses / Q000401:mortality*; D016377:Organ Transplantation / Q000009:adverse effects*; D011379:Prognosis; D012307:Risk Factors; D033581:Stem Cell Transplantation / Q000009:adverse effects*