title: [Fundamental and translational research on hepatocellular carcinoma in 2008: forces and priorities].
abstract: Hepatocellular carcinogenesis is usually the result of a muti-step process. It begins with an exposure to various risk factors; followed by the development of a chronic hepatitis and cirrhosis that is a pre-neoplastic step; and finally after the occurrence of an hepatocellular carcinoma (HCC), different molecular events control aggressiveness of the tumors. The aim of this work was to identify in the international context, forces and priorities of the fundamental and translational HCC research.
authors.affiliation: Inserm, U674 ; université Paris-Diderot-Paris-VII, 75010 Paris, France. zucman@cephb.fr
authors.forename: J
authors.initials: J
authors.lastname: Zucman-Rossi
authors.forename: B
authors.initials: B
authors.lastname: Clément
authors.forename: M-A
authors.initials: MA
authors.lastname: Buendia
authors.forename: H
authors.initials: H
authors.lastname: Lerat
authors.forename: B Van
authors.initials: BV
authors.lastname: Beers
authors.forename: P
authors.initials: P
authors.lastname: Bedossa
authors.forename: J
authors.initials: J
authors.lastname: Taieb
authors.forename: J
authors.initials: J
authors.lastname: Rosenbaum
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D006528:Carcinoma, Hepatocellular / Q000145:classification / Q000209:etiology; D006801:Humans; D033181:Information Dissemination; D008103:Liver Cirrhosis / Q000209:etiology; D008113:Liver Neoplasms / Q000145:classification / Q000209:etiology; D011230:Precancerous Conditions / Q000145:classification / Q000209:etiology; D012106:Research
chemical_list: D014408:Biomarkers, Tumor