HLA-B*2709 and lack of susceptibility to sacroiliitis: further support from the clinic.
Interferons (IFN) are well known triggers of immunomediated diseases in genetically predisposed subjects. We describe the unique case of a HLA-B*2709 positive subject who underwent IFN-alpha treatment for essential thrombocythemia and developed arthritis of the proximal interphalangeal joints of the hands but not sacroiliitis. The possible mechanisms of IFN-induced arthritis are discussed.
Cauli
A
A
Department of Rheumatology, University of Cagliari, Sardinia, Italy. cauli@pacs.unica.it
Vacca
A
A
Dessole
G
G
Fiorillo
M T
MT
Porru
G
G
Ibba
V
V
Mura
V
V
Piga
M
M
Sorrentino
R
R
Mathieu
A
A
D000328:Adult; D001168:Arthritis / Q000139:chemically induced* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects; D016898:Interferon-alpha / Q000009:adverse effects*; D012446:Sacroiliac Joint; D013167:Spondylitis, Ankylosing / Q000235:genetics; D013920:Thrombocythemia, Essential / Q000188:drug therapy* / Q000235:genetics
D015235:HLA-B Antigens; D007155:Immunologic Factors; D016898:Interferon-alpha