title: Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma.
abstract: We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.
authors.affiliation: Istituto di Ematologia, Universita' Cattolica S. Cuore, Rome, Italy. stefan.hohaus@rm.unicatt.it
authors.forename: Stefan
authors.initials: S
authors.lastname: Hohaus
authors.forename: Manuela
authors.initials: M
authors.lastname: Giachelia
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Massini
authors.forename: Barbara
authors.initials: B
authors.lastname: Vannata
authors.forename: Marianna
authors.initials: M
authors.lastname: Criscuolo
authors.forename: Maurizio
authors.initials: M
authors.lastname: Martini
authors.forename: Francesco
authors.initials: F
authors.lastname: D'Alo'
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Voso
authors.forename: Luigi Maria
authors.initials: LM
authors.lastname: Larocca
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leone
mesh_terms: D000328:Adult; D004273:DNA, Neoplasm / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis; D005260:Female; D005784:Gene Amplification; D014644:Genetic Variation; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006720:Homozygote; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic
chemical_list: D004273:DNA, Neoplasm; D016753:Interleukin-10