Emerging issues for tropomyosin structure, regulation, function and pathology.
There is a growing awareness of the role of tropomyosin in the regulation of the actin filament. Work in the field is increasingly directed at understanding the mechanisms of function at both a molecular and atomic level and developing therapeutic strategies to treat tropomyosin-based pathology. This chapter highlights unresolved issues that cross the boundaries between individual chapters and are likely to be fertile areas of research in the future.
Gunning
Peter
P
Oncology Research Unit, Department of Pharmacology, School of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia. p.gunning@unsw.edu.au
D008841:Actin Cytoskeleton / Q000737:chemistry; D000199:Actins / Q000737:chemistry; D000818:Animals; D019281:Dimerization; D005786:Gene Expression Regulation; D006801:Humans; D009154:Mutation; D011108:Polymers / Q000737:chemistry; D011485:Protein Binding; D011487:Protein Conformation; D020033:Protein Isoforms; D015398:Signal Transduction; D014335:Tropomyosin / Q000737:chemistry* / Q000502:physiology*
D000199:Actins; D011108:Polymers; D020033:Protein Isoforms; D014335:Tropomyosin