Genetic network inference as a series of discrimination tasks.
BACKGROUND
Genetic network inference methods based on sets of differential equations generally require a great deal of time, as the equations must be solved many times. To reduce the computational cost, researchers have proposed other methods for inferring genetic networks by solving sets of differential equations only a few times, or even without solving them at all. When we try to obtain reasonable network models using these methods, however, we must estimate the time derivatives of the gene expression levels with great precision. In this study, we propose a new method to overcome the drawbacks of inference methods based on sets of differential equations.


RESULTS
Our method infers genetic networks by obtaining classifiers capable of predicting the signs of the derivatives of the gene expression levels. For this purpose, we defined a genetic network inference problem as a series of discrimination tasks, then solved the defined series of discrimination tasks with a linear programming machine. Our experimental results demonstrated that the proposed method is capable of correctly inferring genetic networks, and doing so more than 500 times faster than the other inference methods based on sets of differential equations. Next, we applied our method to actual expression data of the bacterial SOS DNA repair system. And finally, we demonstrated that our approach relates to the inference method based on the S-system model. Though our method provides no estimation of the kinetic parameters, it should be useful for researchers interested only in the network structure of a target system.


BACKGROUND
Supplementary data are available at Bioinformatics online.
Kimura
Shuhei
S
Graduate School of Engineering, Tottori University, Koyama-minami, Tottori, Japan. kimura@ike.tottori-u.ac.jp
Nakayama
Satoshi
S
Hatakeyama
Mariko
M
D000465:Algorithms; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods; D053263:Gene Regulatory Networks