Highly efficient and regioselective platinum(II)-catalyzed tandem synthesis of multiply substituted indolines and tetrahydroquinolines.
A special advantage: The platinum(II)-catalyzed tandem cyclization of aminoalkynes with 1,3-diketones offers a new and highly efficient method for the synthesis of indolines and tetrahydroquinolines (see scheme; M.S. = molecular sieves). This transformation affords good to excellent product yields with high regio- and chemoselectivity under mild reaction conditions.
Liu
Xin-Yuan
XY
Department of Chemistry and Open Laboratory of Chemical Biology, Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
Che
Chi-Ming
CM
D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010984:Platinum / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
D007211:Indoles; D011804:Quinolines; D010984:Platinum; C057812:indoline