title: Efficacy of combined surgery and antifungal therapies for the management of invasive zygomycoses in patients with haematological malignancies.
abstract: We report two cases of invasive zygomycoses occurring in severely immunocompromised patients with haematological malignancies that were successfully treated with liposomal amphotericin B and surgical debridement, followed by oral administration of posaconazole. These cases demonstrated that an early instituted, aggressive and combined therapeutic approach results in a recovery from invasive fungal infection, without any relapse of infection, thanks to secondary prophylaxis using posaconazole.
authors.forename: C G
authors.initials: CG
authors.lastname: Valentini
authors.forename: A
authors.initials: A
authors.lastname: Candoni
authors.forename: L
authors.initials: L
authors.lastname: Fianchi
authors.forename: B
authors.initials: B
authors.lastname: Posteraro
authors.forename: E
authors.initials: E
authors.lastname: Simeone
authors.forename: F
authors.initials: F
authors.lastname: Costa
authors.forename: M
authors.initials: M
authors.lastname: Sanguinetti
authors.forename: M T
authors.initials: MT
authors.lastname: Voso
authors.forename: M
authors.initials: M
authors.lastname: Caira
authors.forename: R
authors.initials: R
authors.lastname: Fanin
authors.forename: L
authors.initials: L
authors.lastname: Pagano
mesh_terms: D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use; D020096:Zygomycosis / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C068538:liposomal amphotericin B; C101425:posaconazole; D000666:Amphotericin B