Expression of cadherin superfamily genes in brain  vascular development.
Cadherins are Ca2+-dependent cell adhesion molecules that are important in vertebrate nervous system development. We identified seven members of the cadherin superfamily (cadherin-4, cadherin-5, cadherin-6, cadherin-6, cadherin-11, protocadherin-1, and protocadherin-17) and an intracellular binding partner of delta-protocadherins, protein phosphatase 1alpha, as novel markers for developing blood vessels in the ferret brain. Some of the cadherin molecules are restricted to specific brain regions or a subset of blood vessels. The expression levels show a peak during perinatal vascular development. Our results suggest that multiple cadherins, which are also involved in neurogenesis, are regulators of angiogenesis in developing vertebrate brain.
Krishna-K
Institute of Anatomy I, University of Jena School of Medicine, Jena, Germany.
Redies
Christoph
C
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D015820:Cadherins / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D005289:Ferrets / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D017403:In Situ Hybridization; D054645:Protein Phosphatase 1 / Q000235:genetics / Q000378:metabolism
D015820:Cadherins; D054645:Protein Phosphatase 1