[Effect of gualou xiebai (GLXB) decoction on platelet-derived growth factor BB (PDGF-BB) expression in lungs from bleomycin A5 induced pulmonary fibrosis in rats].
OBJECTIVE
To investigate the effect and mechanism of Gualou Xiebai (GLXB) decoction on pulmonary fibrosis.


METHODS
Pulmonary fibrosis was induced by bleomycin A5 in SD rats. Rats in treatment group were killed after being treated by GLXB by decoction daily for 28 days. The lungs of all rats were harvested for histopathological studies. The contents of platelet-derived growth factor BB (PDGF-BB) in lungs were measured and compared.


RESULTS
The contents of PDGF-BB in lungs have increased significantly in model group compared with normal group and treatment group (P<0.05).


CONCLUSIONS
GLXB decoction could significantly alleviate the increased PDGF-BB expression in lungs of pulmonary fibrosis rats.
Li
Rui-qin
RQ
Henan University of Traditional Chinese Medicine, Zhengzhou 450008, China. lrqin_5@yahoo.com.cn
Xiao
Hong
H
Zhang
Rui
R
Li
Wei
W
Song
Jian-ping
JP
D000818:Animals; D000077214:Becaplermin; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D007150:Immunohistochemistry; D008168:Lung / Q000187:drug effects* / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D020574:Proto-Oncogene Proteins c-sis; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D051381:Rats
D004365:Drugs, Chinese Herbal; D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; C488004:gualou xiebai baijiutang; D001761:Bleomycin; D000077214:Becaplermin; C025703:bleomycetin