A novel approach for reduction of brown fat uptake on FDG PET.
The aim of this study was to determine whether or not a single dose of a beta-blocker, such as propranolol 40 mg, administered 60 min prior to (18)F-fluorodeoxyglucose ((18)F-FDG) injection would help reduce brown fat uptake of (18)F-FDG. Patients who were referred for either a pre-treatment or a post-treatment evaluation positron emission tomography (PET) scan and who showed (18)F-FDG uptake in brown adipose tissue (BAT) were included in this study. The total number of patients who showed uptake in BAT and in whom a repeat study was carried out after propranolol injection was 40. A repeat PET scan was carried out after an interval of at least 48 h. Propranolol at a dose of 40 mg was given orally 60 min prior to the (18)F-FDG injection. A whole-body PET scan was performed on a dedicated whole-body PET scanner (ADVANCE, GE Medical Systems, Milwaukee, WI), using attenuation correction with 68-Ge external pin sources. We observed that (18)F-FDG uptake in BAT was absent in 36 (90%) patients post propranolol. We conclude that propranolol reduces the uptake of (18)F-FDG in BAT, and thus improves the accuracy of PET imaging.
Agrawal
A
A
Radiation Medicine Centre, Tata Memorial Hospital, Mumbai, India. drarchi23@hotmail.com
Nair
N
N
Baghel
N S
NS
D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging / Q000187:drug effects*; D000293:Adolescent; D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000000981:diagnostic imaging; D049268:Positron-Emission Tomography / Q000379:methods*; D011433:Propranolol / Q000008:administration & dosage*; D011446:Prospective Studies; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D051598:Whole Body Imaging; D055815:Young Adult
D000319:Adrenergic beta-Antagonists; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D011433:Propranolol