title: Unusual manifestations of tegumentary leishmaniasis in AIDS patients from the New World.
abstract: BACKGROUND
  Comorbidity from tegumentary leishmaniasis and AIDS is poorly characterized.
  
  
  OBJECTIVE
  To describe a series of patients coinfected with Leishmania and human immunodeficiency virus (HIV).
  
  
  METHODS
  Clinical records from patients were analysed by demographic data, clinical manifestations, diagnoses, treatments and outcomes.
  
  
  RESULTS
  Fifteen cases of AIDS/tegumentary leishmaniasis were found. The diagnosis of leishmaniasis was confirmed by the detection of Leishmania amastigotes or antigens from the cutaneous or mucosal lesions. The mean CD4+ T-cell count was 84 cells mm(-3) (range 8-258) and all patients were classified as having AIDS according to the Centers for Disease Control and Prevention. A wide range of manifestations was found, varying from a single ulcer to multiple and polymorphic lesions. Mucosal lesions were present in 80% and cutaneous lesions in 73% of patients (53% with mucocutaneous form), disseminated lesions in 60% and genital lesions in 27% of patients. All patients received anti-Leishmania therapy and 53% showed relapses. Sixty-seven per cent received highly active antiretroviral therapy but showed no difference in outcomes and relapses compared with those not using medication. Forty per cent died during the study period. In these patients, the anti-Leishmania antibody and Montenegro skin test were useful in the diagnosis of leishmaniasis, probably because leishmaniasis preceded immunosuppression due to HIV infection.
  
  
  CONCLUSIONS
  Clinical manifestations of tegumentary leishmaniasis in HIV-infected patients are diverse. Our data emphasize possible unusual manifestations of this disease in HIV-infected patients, particularly in severely immunosuppressed cases (< 200 CD4+ cells mm(-3)).
authors.affiliation: Laboratório de Soroepidemiologia e Imunobiologia, Instituto de Medicina Tropical de São Paulo da Universidade de São Paulo, Avenida Dr Enéas de Carvalho Aguiar 500, 05403-000 São Paulo, SP, Brazil. jlindoso@usp.br
authors.forename: J A L
authors.initials: JA
authors.lastname: Lindoso
authors.forename: R N
authors.initials: RN
authors.lastname: Barbosa
authors.forename: M P
authors.initials: MP
authors.lastname: Posada-Vergara
authors.forename: M I S
authors.initials: MI
authors.lastname: Duarte
authors.forename: L K
authors.initials: LK
authors.lastname: Oyafuso
authors.forename: V S
authors.initials: VS
authors.lastname: Amato
authors.forename: H
authors.initials: H
authors.lastname: Goto
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology / Q000473:pathology*; D000328:Adult; D018791:CD4 Lymphocyte Count; D003937:Diagnosis, Differential; D004812:Epidemiologic Methods; D005260:Female; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host; D016773:Leishmaniasis, Cutaneous / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology*