The SIE, SRE, CRE, and FAP-1 four intracellular signal pathways between stimulus and the expression of c-fos promoter.
c-fos gene has a close relationship with the osteoblasts. Mechanical signal effect on osteoblasts would change the expression level of c-fos. Authors introduce the signal pathways of four cis-response elements on the promoter of c-fos, that is, CRE (cAMP responsive element), FAP-1 (Fbs-AP-1 site), SRE (serum response element), and SIE (sis-inducible element), as the regulatory mechanism for c-fos gene expression following various stimuli.
He
Hong
H
Department of Stomatology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China.
Ping
Feiyun
F
D000242:Cyclic AMP; D005786:Gene Expression Regulation; D006801:Humans; D011401:Promoter Regions, Genetic; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics*; D020574:Proto-Oncogene Proteins c-sis; D020218:Response Elements; D027602:Serum Response Element; D015398:Signal Transduction; D018808:Transcription Factor AP-1
D016760:Proto-Oncogene Proteins c-fos; D020574:Proto-Oncogene Proteins c-sis; D018808:Transcription Factor AP-1; D000242:Cyclic AMP