3,4-Diamino-1,2,5-thiadiazole as potent and selective CXCR2 antagonists.
A series of potent and selective 3,4-diamino-1,2,5-thiadiazoles were prepared and found to show excellent binding affinities towards CXCR2 receptor.
Biju
Purakkattle
P
Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.
Taveras
Arthur G
AG
Yu
Younong
Y
Zheng
Junying
J
Hipkin
R William
RW
Fossetta
James
J
Fan
Xuedong
X
Fine
Jay
J
Lundell
Daniel
D
D003959:Diamines / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D011485:Protein Binding; D023063:Receptors, Interleukin-8B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D003959:Diamines; D023063:Receptors, Interleukin-8B; D013830:Thiadiazoles