title: Contribution of the autolysin AtlA to the bactericidal activity of amoxicillin against Enterococcus faecalis JH2-2.
abstract: The bactericidal activity of amoxicillin was investigated against Enterococcus faecalis JH2-2 and against an isogenic mutant deficient in the production of the N-acetylglucosaminidase AtlA. Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis.
authors.affiliation: Faculté de Médecine Xavier Bichat, Université Paris 7, Paris, France.
authors.forename: Anne-Lise
authors.initials: AL
authors.lastname: Bravetti
authors.forename: Stéphane
authors.initials: S
authors.lastname: Mesnage
authors.forename: Agnès
authors.initials: A
authors.lastname: Lefort
authors.forename: Françoise
authors.initials: F
authors.lastname: Chau
authors.forename: Catherine
authors.initials: C
authors.lastname: Eckert
authors.forename: Louis
authors.initials: L
authors.lastname: Garry
authors.forename: Michel
authors.initials: M
authors.lastname: Arthur
authors.forename: Bruno
authors.initials: B
authors.lastname: Fantin
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D013293:Enterococcus faecalis / Q000187:drug effects*; D009238:N-Acetylmuramoyl-L-alanine Amidase / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D009238:N-Acetylmuramoyl-L-alanine Amidase