Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains.
The frequency of typical and atypical Beijing strains of Mycobacterium tuberculosis was determined in the Netherlands; Vietnam; and Hong Kong Special Administrative Region, People's Republic of China. The strains' associations with drug resistance, M. bovis BCG vaccination, and patient characteristics were assessed. BCG vaccination may have positively selected the prevalent typical Beijing strains.
Kremer
Kristin
K
National Institute for Public Health and the Environment, Bilthoven, the Netherlands. kristin.kremer@rivm.nl
van-der-Werf
Marieke J
MJ
Au
Betty K Y
BK
Anh
Dang D
DD
Kam
Kai M
KM
van-Doorn
H Rogier
HR
Borgdorff
Martien W
MW
van-Soolingen
Dick
D
D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology*; D000940:Antigenic Variation; D000995:Antitubercular Agents / Q000494:pharmacology; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D002681:China; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial; D005260:Female; D005838:Genotype; D006723:Hong Kong; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D009426:Netherlands; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D014611:Vaccination; D014744:Vietnam
D000907:Antibodies, Bacterial; D000995:Antitubercular Agents; D001500:BCG Vaccine; D004251:DNA Transposable Elements; D007538:Isoniazid