When structural and electronic analogy leads to reactivity: the unprecedented phosphodiesterase activity of vanadates.
The interaction between an RNA model phosphodiester and oxovanadate complexes results in a purely hydrolytic cleavage of a phosphodiester bond under physiological pH and temperature: a comparison of the rate-pH profile with the species distribution diagram indicates that the negatively charged tetravanadate [V(4)O(12)](4-), which forms at toxic vanadium levels, is the hydrolytically active species.
Steens
Nele
N
Katholieke Universiteit Leuven, Department of Chemistry, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
Ramadan
Ahmed M
AM
Parac-Vogt
Tatjana N
TN
D004583:Electrons; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010755:Organophosphates; D009943:Organophosphorus Compounds / Q000737:chemistry* / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry* / Q000378:metabolism; D013696:Temperature; D014638:Vanadates / Q000737:chemistry* / Q000378:metabolism
C436487:2-(hydroxypropyl)-4-nitrophenyl phosphate; D010755:Organophosphates; D009943:Organophosphorus Compounds; D014638:Vanadates; D010727:Phosphoric Diester Hydrolases