title: In vitro evaluation of antibacterial, anticollagenase, and antioxidant activities of hop components (Humulus lupulus) addressing acne vulgaris.
abstract: Seven naturally derived components from hop plant (Humulus lupulus L.) extracts were tested for evaluation of biological activities affecting acne vulgaris. Five strains, Propionibacterium acnes, Staphylococcus epidermidis, Staphylococcus aureus, Kocuria rhizophila and, Staphylococcus pyogenes, were selected as the main acne-causing bacteria. Hop extracts xanthohumol and the lupulones showed strong inhibitory activities against all of the strains. Although hydrogenated derivatives did not show the same level of activity, naturally occurring xanthohumol, humulones, and lupulones all showed moderate to strong anticollagenase inhibitory activities. Antioxidant capacity was also evaluated with seven different methods based on different reactive oxygen species. Xanthohumol showed the highest activity in total oxygen radical absorbance capacity as well as singlet oxygen absorbance capacity.
authors.affiliation: Betal, LLC, 5185 MacArthur Blvd, NW, Suite 300, Washington, DC 20016, USA.
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Satoh-Yamaguchi
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Ono
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy; D039903:Actinobacteria / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000009:adverse effects; D053138:Cyclohexenes / Q000494:pharmacology; D005419:Flavonoids; D006801:Humans; D027582:Humulus; D020781:Matrix Metalloproteinase 1 / Q000378:metabolism; D020784:Matrix Metalloproteinase 8 / Q000378:metabolism; D061965:Matrix Metalloproteinase Inhibitors; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010851:Picrates / Q000009:adverse effects; D010936:Plant Extracts / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000187:drug effects; D011427:Propiophenones / Q000494:pharmacology; D013210:Staphylococcus / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D053138:Cyclohexenes; D005419:Flavonoids; D061965:Matrix Metalloproteinase Inhibitors; D010851:Picrates; D010936:Plant Extracts; D011427:Propiophenones; D013729:Terpenes; C008299:lupulon; C004931:1,1-diphenyl-2-picrylhydrazyl; D020784:Matrix Metalloproteinase 8; D020781:Matrix Metalloproteinase 1; C007966:humulon; C104536:xanthohumol