Selective [3 + 2] Huisgen cycloaddition. Synthesis of trans-disubstituted triazolodiazepines from aza-Baylis-Hillman adducts.
The 1,3-dipolar cycloaddition of linear azido alkynes derived from protected beta-amino esters proceeds via diastereomeric differentiation to provide trans-disubstituted triazolodiazepines in good yields.
Declerck
Valérie
V
Institut des Biomolécules Max Mousseron, UMR 5247 CNRS-Université Montpellier 2, 34095 Montpellier Cedex 5, France.
Toupet
Loic
L
Martinez
Jean
J
Lamaty
Frédéric
F
D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D001381:Azepines; D014230:Triazoles; C052518:WEB 2086