Anti-inflammatory activities of methanol extracts from various seaweed species.
Thirty-seven species of common seaweeds from the coast of Korea were screened for anti-inflammatory activity Methanol extracts of the seaweeds were tested against mouse ear edema and erythema induced by phorbol myristate acetate. At 40 mg ml(-1) of extract, edema was strongly suppressed by the seaweeds Undaria pinnatifida and Ulva linza, with relative inhibition of 85 and 84%, respectively These two seaweeds also showed the greatest suppression of erythema, with inhibition of 78 and 70%, respectively IC50 values of U. pinnatifida were 10, 15, and 18 mg ml(-1) when inflammation symptoms of edema, erythema, and blood flow, respectively were measured. The IC50 of U. linza was 20, 26, and 31 mg ml(-1) when edema, erythema, and blood flow, respectively, were measured. A linear correlation among inhibition rates of edema, erythema, and blood flow was observed with high confidence.
Khan
Mohammed N A
MN
Faculty of Food Science and Biotechnology, and Institute of Fisheries Sciences, Pukyong National University, Namku, Busan-608-737, Korea.
Choi
Jae Suk
JS
Lee
Min Chul
MC
Kim
Eliya
E
Nam
Taek Jeong
TJ
Fujii
Hitoshi
H
Hong
Yong Ki
YK
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001783:Blood Flow Velocity; D004305:Dose-Response Relationship, Drug; D004423:Ear / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004890:Erythema / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D020128:Inhibitory Concentration 50; D007723:Korea; D000432:Methanol / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D012624:Seaweed / Q000737:chemistry* / Q000145:classification; D013755:Tetradecanoylphorbol Acetate
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D013755:Tetradecanoylphorbol Acetate; D000432:Methanol