Role of serum cytokines tumour necrosis factor-alpha and interleukin-6 in the association between body weight and periodontal infection.
OBJECTIVE
To study the role of serum cytokines tumour necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) as potential mediators in the association between body weight and periodontal infection among an adult population.


METHODS
This study was based on a subpopulation of the Health 2000 Health Examination Survey, which included dentate non-diabetic, non-rheumatic subjects, aged between 45 and 64 years, who had never smoked and whose serum levels of TNF-alpha and IL-6 were analysed and whose periodontal status was clinically determined (effective n=425). The number of teeth with periodontal pockets of 4 mm or more and the number of teeth with periodontal pockets of 6 mm or more were used as outcome variables. Relative risks and 95% confidence intervals were estimated using Poisson regression models.


RESULTS
Serum IL-6, but not TNF-alpha associated with teeth with deepened periodontal pockets. Multivariate models showed that IL-6, but not TNF-alpha, could mediate the effect of body weight on periodontium.


CONCLUSIONS
In this population of non-diabetic and non-rheumatic subjects, who had never smoked, serum IL-6 was associated with periodontal infection. The results suggest that serum IL-6 could be one mediating factor that connects body weight and periodontal infection.
Saxlin
Tuomas
T
Institute of Dentistry, University of Oulu, Oulu, Finland. tuomas.saxlin@oulu.fi
Suominen-Taipale
Liisa
L
Leiviskä
Jaana
J
Jula
Antti
A
Knuuttila
Matti
M
Ylöstalo
Pekka
P
D001424:Bacterial Infections / Q000097:blood; D001835:Body Weight; D055113:Chronic Periodontitis / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000097:blood* / Q000150:complications; D012044:Regression Analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha