title: Synthetic studies toward sordarin: building blocks for the terpenoid core and for analogues thereof.
abstract: Avenues to bi- and tricyclic building blocks for the elaboration of sordaricin and its analogues are described. The target molecules were obtained through inter- and intramolecular Diels-Alder reactions of a number of previously unknown cyclopentadienes. Unusual properties of 3-cyanoenones and 1-cyanocyclopentadienes have been unveiled and circumvented.
authors.affiliation: Laboratoire de Synthèse et Méthodologie Organiques, CNRS UMR 5181, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, 43, Bd. du 11 Novembre 1918, 69622 Villeurbanne, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Schulé
authors.forename: Huan
authors.initials: H
authors.lastname: Liang
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Vors
authors.forename: Marco A
authors.initials: MA
authors.lastname: Ciufolini
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D003517:Cyclopentanes / Q000737:chemistry; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry; D011500:Protein Synthesis Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013729:Terpenes / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D003517:Cyclopentanes; D007192:Indenes; D009570:Nitriles; D011500:Protein Synthesis Inhibitors; D013729:Terpenes; C003329:sordarin; D010100:Oxygen