Catechols as membrane anion transporters.
We report that an amphiphilic bis-catechol (3) functions as a transmembrane anion transporter. Activity depends on the catechol's substitution and amphiphilicity. We also describe a liposomal assay that allows one to readily measure anion transport selectivity. This assay reveals that anion transport selectivity for this amphiphilic bis-catechol follows a Hofmeister sequence wherein anions that are easier to dehydrate are made more permeable to the membrane by 3.
Berezin
Sofya Kostina
SK
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Davis
Jeffery T
JT
D000838:Anions / Q000737:chemistry; D002396:Catechols / Q000737:chemistry* / Q000378:metabolism*; D002463:Cell Membrane Permeability; D018118:Chloride Channels / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008081:Liposomes / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D027361:Organic Anion Transporters / Q000737:chemistry* / Q000378:metabolism*; D013816:Thermodynamics
D000838:Anions; D002396:Catechols; D018118:Chloride Channels; D008051:Lipid Bilayers; D008081:Liposomes; D027361:Organic Anion Transporters