Okundoperoxide, a bicyclic cyclofarnesylsesquiterpene endoperoxide from Scleria striatinux with antiplasmodial activity.
Okundoperoxide (1) was isolated by bioassay-guided fractionation of extracts from Scleria striatinux (syn. S. striatonux). The compound contains a cyclic endoperoxide structural moiety and possesses moderate antimalarial activity.
Efange
Simon M N
SM
Department of Chemistry, University of Buea, PO Box 63, Buea, Southwest Province, Cameroon. smnefange@yahoo.com
Brun
Reto
R
Wittlin
Sergio
S
Connolly
Joseph D
JD
Hoye
Thomas R
TR
McAkam
Thomas
T
Makolo
Felix L
FL
Mbah
James A
JA
Nelson
Dorian P
DP
Nyongbela
Kennedy D
KD
Wirmum
Clare K
CK
D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D029785:Cyperaceae / Q000737:chemistry*; D004351:Drug Resistance / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013237:Stereoisomerism
D000962:Antimalarials; D012717:Sesquiterpenes; C550401:okundoperoxide; D002738:Chloroquine