Multivariate explanatory model for sporadic carcinoma of the colon in Dukes' stages I and IIa.
OBJECTIVE
We obtained before an explanatory model with six dependant variables: age of the patient, total cholesterol (TC), HDL cholesterol (HDL-C), VLDL cholesterol (VLDL-C), alkaline phosphatase (AP) and the CA 19.9 tumour marker. Our objective in this study was to validate the model by means of the acquisition of new records for an additional analysis.


METHODS
Non-paired case control study.


METHODS
Urban and rural hospitals and primary health facilities in Western Andalusia and Extremadura (Spain).


METHODS
At both the primary care facilities and hospital level, controls were gathered in a prospective manner (n= 275). Cases were prospective and retrospective manner collected on (n=126).


METHODS
Descriptive statistics, logistic regression and bootstrap analysis.


RESULTS
The AGE (odds ratio 1.02; 95% CI 1.003-1.037) (p= 0.01), the TC (odds ratio 0.986; 95% C.I. 0.980-0.992) (p< 0.001) and the CA 19.9 (odds ratio 1.023; 95% C.I. 1.012- 1.034) (p<0.001) were the variables that showed significant values at logistic regression analysis and bootstrap. Berkson's bias was statistically assessed.


CONCLUSIONS
The model, validated by means of logistic regression and bootstrap analysis, contains the variables AGE, TC, and CA 19.9 (three of the original six) and has a level 4 over 5 according to the criteria of Justice et al. (multiple independent validations) [Ann. Intern. Med.1999; 130: 515].
Villadiego-Sánchez
J M
JM
061 Accident and Emergency Service, Huelva, Spain.
Ortega-Calvo
M
M
Pino-Mejías
R
R
Cayuela
A
A
Iglesias-Bonilla
P
P
García-de la Corte
F
F
Santos-Lozano
J M
JM
Lapetra-Peralta
José
J
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D016017:Odds Ratio; D012372:ROC Curve; D013030:Spain; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D018395:CA-19-9 Antigen; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol; D000469:Alkaline Phosphatase