title: One-year glargine treatment can improve the course of lung disease in children and adolescents with cystic fibrosis and early glucose derangements.
abstract: BACKGROUND
  Diabetes increases morbidity and mortality in cystic fibrosis (CF) patients, but several studies indicate that also prediabetic status may have a potential impact on both nutrition and lung function.
  
  
  OBJECTIVE
  To evaluate the effect of glargine on the clinical course in CF patients with early glucose derangements.
  
  
  METHODS
  CF population was screened for glucose tolerance. CF patients with age >10 yr were screened with fasting hyperglycemia (FH). CF patients with age >10 yr without FH and those with age <10 yr with occasional FH were evaluated for glucose abnormalities on the basis of oral glucose tolerance test and/or continuous glucose monitoring system. All CF patients with glucose derangements were enrolled in an open clinical trial with glargine. Body mass index (BMI) z-score, forced expiratory volume in the first second (FEV(1)), number of acute pulmonary exacerbations and hemoglobin A1c, were as outcome measures at baseline and after 1 yr of treatment.
  
  
  RESULTS
  After 12 months of therapy, BMI z-score improved only in patients with baseline BMI z-score less than -1 (p = 0.017). An 8.8% increase in FEV(1) (p = 0.01) and 42% decrease in the number of pulmonary exacerbations (p = 0.003) were found in the whole group compared with previous 12 months of therapy.
  
  
  CONCLUSIONS
  Glargine could represent an innovative strategy to prevent lung disease progression in CF patients with early glucose derangements. Larger controlled trials are needed to better clarify the effects of insulin on clinical status in CF patients with early glucose derangements.
authors.affiliation: Department of Pediatrics, Federico II University of Naples, Naples, Italy. enzamozzillo@libero.it
authors.forename: Enza
authors.initials: E
authors.lastname: Mozzillo
authors.forename: Adriana
authors.initials: A
authors.lastname: Franzese
authors.forename: Giuliana
authors.initials: G
authors.lastname: Valerio
authors.forename: Angela
authors.initials: A
authors.lastname: Sepe
authors.forename: Ilaria
authors.initials: I
authors.lastname: De Simone
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Mazzarella
authors.forename: Pasqualina
authors.initials: P
authors.lastname: Ferri
authors.forename: Valeria
authors.initials: V
authors.lastname: Raia
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood / Q000150:complications*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000453:epidemiology; D005541:Forced Expiratory Volume; D018149:Glucose Intolerance / Q000188:drug therapy* / Q000453:epidemiology*; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy / Q000453:epidemiology; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting; D008171:Lung Diseases / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013147:Spirometry; D016896:Treatment Outcome
chemical_list: D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D000069036:Insulin Glargine; D049528:Insulin, Long-Acting