title: Heart transplantation.
abstract: Over the past 40 years, heart transplantation has become a routine treatment for end-stage heart failure. Over 3000 heart transplants are performed annually. Despite improvements in short-term outcomes, long-term survival remains limited. Current efforts remain directed at alleviating the shortage of donor organs, developing effective treatments for chronic rejection, and improving mechanical circulatory support for heart failure.
authors.affiliation: Department of Cardiothoracic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Yun
authors.forename: G
authors.initials: G
authors.lastname: Gonzalez-Stawinski
mesh_terms: D000367:Age Factors; D000818:Animals; D006348:Cardiac Surgical Procedures / Q000379:methods; D046148:Donor Selection; D006331:Heart Diseases / Q000601:surgery; D006333:Heart Failure / Q000266:history / Q000401:mortality / Q000601:surgery*; D016027:Heart Transplantation / Q000266:history / Q000379:methods* / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D018579:Patient Selection; D011379:Prognosis; D013997:Time Factors; D009927:Tissue and Organ Procurement / Q000266:history / Q000639:trends; D016896:Treatment Outcome