A simple model for exploring conformation of highly-charged electrosprayed single-stranded oligonucleotides.
The study of the maximum charge state versus the molecular weight of single-stranded polynucleotides analyzed by electrospray reveals that single strands adopt a compact conformation in positive ion mode, whereas linear structures are predominant in negative ion mode.
Touboul
David
D
Department of Chemistry and Applied Biosciences, ETH Zürich, CH-8093 Zürich, Switzerland.
Zenobi
Renato
R
D000465:Algorithms; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
D009841:Oligonucleotides