EEG markers discriminate among different subgroup of patients with mild cognitive impairment.
Aim of the study is to discriminate among participants with mild cognitive impairment through electroencephalography brain rhythms. A total of 79 participants with MCI were classified into 4 subgroups based on the beginning of memory complaints up to the time of first visit. All participants underwent electroencephalography recording, magnetic resonance imaging, apolipoprotein E characterization, and volumetric morphometry estimation of hippocampal region. Electroencephalography markers show 2 distinct patterns: (1) increase of theta/ delta power ratio and highest value of alpha2 band power in the group with shorter duration of disease, the greater right-left hippocampal volume difference and worst memory performance; (2) the highest value of alpha3 band power and the highest alpha3/alpha2 power ratio in the group with the lesser total hippocampal volume but preserved memory performance. Apolipoprotein E4 is linked to a major risk of early beginning of disease. Electroencephalography markers allow a mean correct percentage of correct classification up to 89%.
Moretti
D V
DV
Neurophysiology, IRCCS S. Giovanni di Dio Fatebenefratelli, Brescia, Italy. davide.moretti@afar.it
Pievani
M
M
Geroldi
C
C
Binetti
G
G
Zanetti
O
O
Rossini
P M
PM
Frisoni
G B
GB
D000368:Aged; D000369:Aged, 80 and over; D000513:Alpha Rhythm; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000378:metabolism; D001057:Apolipoproteins E / Q000378:metabolism; D003072:Cognition Disorders / Q000175:diagnosis* / Q000453:epidemiology; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D015995:Prevalence; D012720:Severity of Illness Index
D001057:Apolipoproteins E