Radio-induced low-grade glioma: report of two cases and review of the literature.
With the increasing number of cancer survivors, we can observe a population that will present a higher risk of developing secondary long-term toxicities related to adjuvant chemo and radiotherapy regimens. Among these, children surviving from acute lymphoblastic leukemia (ALL) that were treated with prophylactic cranial irradiation represent a group of patients at a high risk of developing secondary brain tumors. Radiation-induced intracranial tumors have been documented since 1950, and today, more than one-hundred cases have been described. We report our experience with two young patients who were hospitalized for low grade gliomas and had a positive anamnesis for ALL and consequent radiotherapy.
D'Elia
Alessandro
A
Department of Neurological Sciences, Neurosurgery, Policlinico Umberto I, University of Rome Sapienza, Rome, Italy. deliaale@gmail.com
Melone
Graziella Angelina
GA
Brogna
Christian
C
Formichella
Anna
A
Santoro
Antonio
A
Salvati
Maurizio
M
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001037:Aphasia / Q000209:etiology; D001921:Brain / Q000473:pathology / Q000528:radiation effects* / Q000601:surgery; D001931:Brain Mapping; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005625:Frontal Lobe / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D005910:Glioma / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007049:Iatrogenic Disease / Q000517:prevention & control; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000209:etiology; D019635:Neurosurgical Procedures; D011183:Postoperative Complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*; D013702:Temporal Lobe / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D016896:Treatment Outcome