title: Central quadrant procurement of radical prostatectomy specimens.
abstract: Obtaining high quality fresh or frozen prostate tissue in gram amounts promotes the research of prostate cancer. Due to the inability to effectively recognize prostate cancer upon the cut section of a fresh prostate many pathology departments perform whole organ processing precluding the procurement of prostate tissue. Some sites randomly procure tissue, while others perform specialized procedures that can be difficult to duplicate. Neither of these types of procurement consistently results in gram quantities of tissue procured from each prostate with a high percentage of samples yielding tissue corresponding to cancer. In this study, we present a simplified model of prostate tissue procurement that has no impact on Gleason grade, tumor stage or margin status, requires minimal specialized processing, and obtains gram amounts of fresh tissue from each radical prostatectomy specimen with a high percentage yielding cancer tissue.
authors.affiliation: Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, New York 14263, USA. carl.morrison@roswellpark.org
authors.forename: Carl
authors.initials: C
authors.lastname: Morrison
authors.forename: Richard
authors.initials: R
authors.lastname: Cheney
authors.forename: Candace S
authors.initials: CS
authors.lastname: Johnson
authors.forename: Gary
authors.initials: G
authors.lastname: Smith
authors.forename: James L
authors.initials: JL
authors.lastname: Mohler
mesh_terms: D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D012334:RNA, Neoplasm / Q000737:chemistry / Q000235:genetics; D013048:Specimen Handling / Q000379:methods*
chemical_list: D012334:RNA, Neoplasm