title: Effects of Lactobacillus casei and Bifidobacterium breve on urinary oxalate excretion in nephrolithiasis patients.
abstract: It had been suggested that lactic acid bacteria (LAB) may degrade oxalate in the intestinal lumen, reducing urinary oxalate excretion. We aimed to evaluate the effect of a LAB mixture containing Lactobacillus casei (LC) and Bifidobacterium breve (BB) (LC + BB) upon urinary oxalate reduction in stone-forming (SF) patients without hyperoxaluria under conditions of an oxalate-rich diet. After an oxalate restriction period (7 days washout), 14 SF patients consumed an oxalate-rich diet during 4 weeks (200 mg/day) and a lyophilized LC + BB preparation was given t.i.d. after meals during the last 2 weeks. Twenty-four-hour urine samples were collected for determination of oxalate, calcium, magnesium, citrate, sodium, potassium and creatinine at baseline, after 2 weeks (DIET) and 4 weeks (DIET + LC + BB). The mean urinary oxalate excretion was significantly higher after DIET versus baseline (27 +/- 8 vs. 35 +/- 11 mg/24 h), but the mean decrease was not significant between DIET + LC + BB and DIET periods (35 +/- 11 vs. 33 +/- 10 mg/24 h). Seven out of 14 patients presented a reduction in oxaluria after LC + BB versus DIET, being the reduction higher than 25% in 4, and up to 50% in 2 of them. The latter two patients were those who had presented the greatest increase in oxaluria in response to dietary oxalate. In conclusion, this mixture of L. casei and B. breve was shown to possess a variable lowering effect upon urinary oxalate excretion that may be dependent on dietary oxalate intake.
authors.affiliation: Nephrology Division, Universidade Federal de São Paulo, UNIFESP, Rua: Botucatu, 740, Vila Clementino, 04023-900, São Paulo, SP, Brazil.
authors.forename: Renato Ribeiro Nogueira
authors.initials: RR
authors.lastname: Ferraz
authors.forename: Natália Cristina
authors.initials: NC
authors.lastname: Marques
authors.forename: Leila
authors.initials: L
authors.lastname: Froeder
authors.forename: Viviane Barcellos
authors.initials: VB
authors.lastname: Menon
authors.forename: Priscila Reina
authors.initials: PR
authors.lastname: Siliano
authors.forename: Alessandra Calábria
authors.initials: AC
authors.lastname: Baxmann
authors.forename: Ita Pfeferman
authors.initials: IP
authors.lastname: Heilberg
mesh_terms: D000328:Adult; D001644:Bifidobacterium / Q000378:metabolism; D004032:Diet; D005260:Female; D005504:Food Analysis; D006801:Humans; D007780:Lacticaseibacillus casei / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D053040:Nephrolithiasis / Q000382:microbiology / Q000628:therapy* / Q000652:urine*; D010070:Oxalates / Q000008:administration & dosage / Q000652:urine*; D019936:Probiotics / Q000627:therapeutic use*
chemical_list: D010070:Oxalates