Obesity and albuminuria among adults with type 2 diabetes: the Look AHEAD (Action for Health in Diabetes) Study.
OBJECTIVE
To determine the association between obesity measures and albuminuria in adults with type 2 diabetes.


METHODS
In the Look AHEAD (Action for Health in Diabetes) Study, BMI and waist circumference were measured among 4,985 participants while total percent body fat was measured by whole-body DEXA scans among 1,351 participants. Odds of albuminuria by quartiles of BMI, waist circumference, and percent total body fat were calculated using logistic regression analysis while adjusting for covariates.


RESULTS
The highest quartile of BMI (odds ratio [OR] 1.72 [95% CI 1.40-2.11]) and waist circumference (OR 1.75 [95% CI 1.42-2.15]) was significantly associated with albuminuria compared with the lowest quartile after adjustment for covariates. No associations were noted between quartiles of percent total body fat and albuminuria in any model.


CONCLUSIONS
Increased BMI and abdominal obesity are associated with albuminuria in overweight and obese adults with type 2 diabetes.
Kramer
Holly
H
Department of Preventive Medicine and Epidemiology, Division of Nephrology and Hypertension, Loyola University Medical Center, Maywood, Illinois, USA. hkramer@lumc.edu
Reboussin
David
D
Bertoni
Alain G
AG
Marcovina
Santica
S
Lipkin
Edward
E
Greenway
Frank L
FL
Brancati
Frederick L
FL
D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D000419:Albuminuria / Q000453:epidemiology*; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology / Q000652:urine; D006801:Humans; D008019:Life Style; D015337:Multicenter Studies as Topic; D009765:Obesity / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology / Q000652:urine; D016032:Randomized Controlled Trials as Topic; D055105:Waist Circumference