title: Mannose-binding lectin pathway is not involved in myasthenia gravis pathogenesis.
abstract: Classical complement pathway factor, C4 is required for experimental autoimmune myasthenia gravis (EAMG) pathogenesis. C4 is also a central component of the mannose binding lectin (MBL) pathway suggesting that this pathway might also be involved in MG pathogenesis. However, MBL gene deficient mice displayed intact anti-acetylcholine receptor (AChR)-immune response and neuromuscular junction (NMJ) IgG and complement accumulation following AChR-immunization. Moreover, no significant difference was observed between the serum MBL levels of 77 anti-AChR antibody positive generalized MG patients and 105 healthy controls. Therefore, MBL pathway does not play a role in EAMG/MG pathogenesis.
authors.affiliation: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, 77555-1070, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Huibin
authors.initials: H
authors.lastname: Qi
authors.forename: Erdem
authors.initials: E
authors.lastname: Tüzün
authors.forename: Windy
authors.initials: W
authors.lastname: Allman
authors.forename: Vuslat
authors.initials: V
authors.lastname: Yilmaz
authors.forename: Shamsher S
authors.initials: SS
authors.lastname: Saini
authors.forename: Feza
authors.initials: F
authors.lastname: Deymeer
authors.forename: Güher
authors.initials: G
authors.lastname: Saruhan-Direskeneli
authors.forename: Premkumar
authors.initials: P
authors.lastname: Christadoss
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D037582:Complement Pathway, Mannose-Binding Lectin / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000097:blood / Q000276:immunology*; D011950:Receptors, Cholinergic / Q000276:immunology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*; D014101:Torpedo
chemical_list: D007074:Immunoglobulin G; D037601:Mannose-Binding Lectin; D011950:Receptors, Cholinergic