Crosstalk between the SUMO and ubiquitin pathways.
Several ways in which the SUMO and ubiquitin pathways can intersect and communicate have recently been discovered. This review discusses the principles of crosstalk between SUMOylation and ubiquitination, focusing on the RNF4 family of RING finger E3 ubiquitin ligases, which specifically recognize SUMOylated proteins via their SUMO moiety for ubiquitination.
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Molecular and Cell Biology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 920137-1099, USA. hunter@salk.edu
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D000818:Animals; D011485:Protein Binding; D054829:RING Finger Domains; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000737:chemistry / Q000145:classification / Q000378:metabolism
D025841:Small Ubiquitin-Related Modifier Proteins; D025801:Ubiquitin; D044767:Ubiquitin-Protein Ligases