title: Update on amyloid-beta homeostasis markers for sporadic Alzheimer's disease.
abstract: Amyloid-beta (Abeta) is either directly involved in the pathogenesis of Alzheimer's disease (AD) or tightly correlated with other primary pathogenic factors. It is produced from amyloid precursor protein (APP) by proteolytic processing dependent on the beta-site APP-cleaving enzyme 1 (BACE1) and gamma-secretase, and is degraded by a broad range of proteases. This update summarizes the currently available studies that have determined the usefulness of BACE1 and secreted fragments of APP and Abeta as cerebrospinal fluid biomarkers for AD.
authors.affiliation: Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at Goteborg University, Molndal, Sweden. henrik.zetterberg@gu.se
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
mesh_terms: D000544:Alzheimer Disease / Q000134:cerebrospinal fluid / Q000201:enzymology / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000096:biosynthesis / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers; D006706:Homeostasis; D006801:Humans; D020033:Protein Isoforms / Q000096:biosynthesis / Q000134:cerebrospinal fluid
chemical_list: D016229:Amyloid beta-Peptides; D015415:Biomarkers; D020033:Protein Isoforms; D053829:Amyloid Precursor Protein Secretases