blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures.
CTX-M-producing Escherichia coli isolates from three Croatian hospitals were analyzed. All bla(CTX-M-15) genes and one bla(CTX-M-3a) gene resided in widely spread ISEcp1 transposition modules, but other bla(CTX-M-3a) genes were in a new configuration with two IS26 copies, indicating a new event of gene mobilization from a Kluyvera ascorbata genome. The study confirmed the role of the E. coli ST131 clonal group with IncFII-type plasmids in the spread of bla(CTX-M-15) and of IncL/M pCTX-M3-type plasmids in the dissemination of bla(CTX-M-3a).
Literacka
Elzbieta
E
National Medicines Institute, Warsaw, Poland.
Bedenic
Branka
B
Baraniak
Anna
A
Fiett
Janusz
J
Tonkic
Marija
M
Jajic-Bencic
Ines
I
Gniadkowski
Marek
M
D001483:Base Sequence; D004251:DNA Transposable Elements; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics*
D004251:DNA Transposable Elements; C473109:beta-lactamase CTX-M-15; C417271:beta-lactamase CTX-M-3; D001618:beta-Lactamases