Fluoride levels of human plasma and breast milk.
OBJECTIVE
The aim of this study was to determine the fluoride levels in breast milk and plasma of lactating mothers who regularly consumed drinking water with low levels of fluoride.


METHODS
One hundred twenty five healthy mothers aged between 20-30 years old who had given birth within 5-7 days were included in the study. Besides being otherwise healthy, the primary selection criteria stipulated the absence of fluoride supplement consumption one month before delivery. Approximately 5 ml breast milk and 5 ml blood samples were obtained from each participating mother at a hospital setting, where the mothers were scheduled for a regular hospital diet. The blood samples were centrifuged in fluoride-free heparinized polyethylene tubes and stored at -18 degrees C until measurements were made. Breast milk samples were directly refrigerated as with blood samples until measurements. The fluoride concentrations of milk and blood samples were assessed using an ion-selective fluoride electrode combined with an ion analyzer.


RESULTS
The fluoride levels of the plasma and breast milk samples were measured as 0.017+/-0.011 ppm and 0.006+/-0.002 ppm, respectively. The fluoride concentration of plasma was significantly higher than that of breast milk (P<.01). Correlation analysis revealed a significant relation between the groups (P<.01).


CONCLUSIONS
A limited level of fluoride transmission from plasma to breast milk was detected. Nevertheless, a significant correlation between the fluoride concentrations of breast milk and plasma was evident.
Sener
Yagmur
Y
Assistant Professor, Selçuk University, Faculty of Dentistry, Department of Pedodontics.
Tosun
Gül
G
Kahvecioglu
Firdevs
F
Gökalp
Alparslan
A
Koç
Hasan
H