Proopiomelanocortin, Preproenkephalin-A and Preprocholecystokinin mRNA in the Hypothalamus of CCI-Treated Rats.
It has previously been shown that beta-endorphin (BE) and cholecystokinin (CCK) concentrations decrease in brain areas of rats or humans affected by severe liver disease (SLD). We now report the increase of proopiomelanocortin (POMC) and preprocholecystokinin mRNA in the hypothalamus and cortex of rats with experimental SLD, suggesting an increased post-translational turnover of BE and CCK in this experimental condition.
Brini
A
A
Department of Pharmacology, School of Medicine, University of Milano, Miiano, Italy.
Morghen
C
C
Bianchi
M
M
Rovati
L C
LC
Panerai
A E
AE