title: [Bleeding secondary to vitamin K antagonist treatment: adaptation of the International Normalized Ratio (INR) determination during high hypertriglyceridemia].
abstract: Vitamin K antagonists (VKA) are the first cause of iatrogenic mortality in France. Therefore, it is crucial to monitor these treatments with the International Normalized Ratio (INR) determination, which can be altered by several plasma elements. We report a patient who presented a serious bleeding event while under VKA treatment related to INR determination difficulties due to a high hypertriglyceridemia. We suggest some solutions (fasting and mechanic method in INR determination) in order to improve the control of the VKA treatment for patients with hypertriglyceridemia.
authors.affiliation: Faculté de médecine d'Angers, rue Haute-de-Reculée, Angers, France. stefmiot@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Miot
authors.forename: A-T
authors.initials: AT
authors.lastname: Marteau
authors.forename: G
authors.initials: G
authors.lastname: Simard
authors.forename: C
authors.initials: C
authors.lastname: Lavigne
mesh_terms: D005260:Female; D006470:Hemorrhage / Q000097:blood* / Q000139:chemically induced*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood*; D019934:International Normalized Ratio; D008875:Middle Aged; D014812:Vitamin K / Q000037:antagonists & inhibitors*
chemical_list: D014812:Vitamin K