title: Velleratretraol, an unusual highly functionalized lactarane sesquiterpene from Lactarius vellereus.
abstract: An unusual highly functionalized lactarane sesquiterpene, named velleratretraol (1), was isolated from the ethanol extract of the fruiting body of the mushroom Lactarius vellereus. Its structure was determined through spectroscopic analysis and single-crystal X-ray diffraction studies. The proposed assignment of the absolute configuration is based on computational results. It showed weak activity against HIV-1 cells with an effective concentration of 68.0 microg ml(-1) and a selectivity index of 2.0.
authors.affiliation: College of Life Science, Key Laboratory of Pharmaceutical Chemistry and Molecular Diagnosis, Ministry of Education and Research Center of Biotechnology of Hebei Province, Hebei University, Baoding, China. duqiangluo@163.com
authors.forename: Du-Qiang
authors.initials: DQ
authors.lastname: Luo
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Zhao
authors.forename: Yao-Long
authors.initials: YL
authors.lastname: Shi
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Tang
authors.forename: Yu-Ye
authors.initials: YY
authors.lastname: Li
authors.forename: Liu-Meng
authors.initials: LM
authors.lastname: Yang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism; D002478:Cells, Cultured; D018360:Crystallography, X-Ray; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006678:HIV / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D019380:Anti-HIV Agents; D007202:Indicators and Reagents; D007783:Lactones; D012717:Sesquiterpenes; C544241:velleratretraol