Asymmetric intramolecular carbocyanation of alkenes by C-C bond activation.
Versatility: Ni(0) and Pd(0) complexes act as catalysts in the intramolecular aryl- and acylcyanation reactions, respectively, of alkenes (see scheme). These reactions not only proceed with high yield and selectivity, they also tolerate a wide range of functional groups and can furnish valuable heterocycles such as oxindoles, which are precursors for a myriad of natural and/or biologically active products.
Nájera
Carmen
C
Departamento de Química Orgánica e Instituto de Síntesis Orgánica, Facultad de Ciencias, Universidad de Alicante, Apartado 99, 03080 Alicante, Spain. cnajera@ua.es
Sansano
José M
JM