[Absorption of fatty acids by the rat heart in arrhythmia].
Fifty-three white rat males were divided into 4 groups: intact, with arrhythmia, with arrhythmia treated with cordaron, with arrhythmia treated with cardiotron. The rats' diet was enriched with animal fats. Anesthesia was made with uretan (1,0-1,2 g/kg, i.p.). Arrhythmia was induced with akonitine (30-40 mg/kg, i.v.). The drugs were administered 12 and 25 days before arrhythmia induction which was registered on ECG at min 3, 5, 15 and 25 in 1, 11 and 111 standard leads. Total lipid fatty acids (TLFA) of plasma were detected in heart inflowing and outflowing blood with gas chromatography. Arrhythmia drastically changes qualitative characteristics of arterio-venous difference for fatty acids. Cordaron and cardiotron prevented arrhythmia in 63-75% cases. TLFA arterio-venous difference recovered by 55-69%. Cordaron and cardiotron may have a mediating mechanism of action on fatty acid absorption by the heart in normalization of normal heart rate in experimental arrhythmia.
Bogdarin
Iu A
IuA
Kozin
V V
VV
Men'kova
I E
IE
Shirokova
N Iu
NIu
D000157:Aconitine / Q000633:toxicity; D000276:Adjuvants, Immunologic / Q000633:toxicity; D000638:Amiodarone / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D005227:Fatty Acids / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats
D000276:Adjuvants, Immunologic; D000889:Anti-Arrhythmia Agents; D005227:Fatty Acids; D000638:Amiodarone; D000157:Aconitine