title: Glycemic index and glycemic load are not associated with brain lesions in the elderly.
abstract: OBJECTIVE
  The goal of this study was to determine if brain lesion volume was correlated with dietary glycemic index and glycemic load in elderly individuals.
  
  
  METHODS
  This cross-sectional study was performed at an academic medical center as part of a clinical study of late-life depression.
  
  
  METHODS
  Subjects (n=137) were age 60 or over, and were participating as non-depressed comparison subjects.
  
  
  METHODS
  Food intake was assessed using the Block 1998 food frequency questionnaire. Glycemic index and glycemic load measures were derived from reported food intake. Brain lesion volumes were calculated from magnetic resonance imaging (MRI).
  
  
  RESULTS
  No significant associations were found between glycemic index or glycemic load, and brain lesion volume.
  
  
  CONCLUSIONS
  Dietary glycemic measures may be unrelated to brain lesions or may be related to brain lesions only in individuals with impaired glycemic control or other vascular risk factors. Further studies are needed to confirm this finding and to determine if glycemic control moderates this association.
authors.affiliation: Department of Clinical Research, Campbell University, Morrisville, NC 27560, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Trone
authors.forename: K G
authors.initials: KG
authors.lastname: Weaver
authors.forename: D C
authors.initials: DC
authors.lastname: Steffens
authors.forename: M E
authors.initials: ME
authors.lastname: Payne
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000209:etiology* / Q000473:pathology; D003430:Cross-Sectional Studies; D004032:Diet; D004034:Diet Surveys; D005260:Female; D038321:Glycemic Index; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male