Strain differences in response to traumatic brain injury in Long-Evans compared to Sprague-Dawley rats.
The selected strain of rodent used in experimental models of traumatic brain injury is typically dependent upon the experimental questions asked and the familiarity of the investigator with a specific rodent strain. This archival study compares the injury responsiveness and recovery profiles of two popular outbred strains, the Long-Evans (LE) and the Sprague-Dawley (SD), after brain injury induced by lateral fluid percussion injury (LFPI). General findings include a significantly longer duration of unconsciousness in LE rats, but similar durations of apnea. Both strains displayed the same level of initial FPI-induced behavioral deficits, followed by a more rapid rate of functional recovery in SD rats. Cortical volume loss was not significantly different, but close inspection of the data suggests the possibility that LE rats may be more susceptible to damage in the hemisphere contralateral to the injury site than are SD rats. It is hoped that the information provided here encourages greater attention to the subtle differences and similarities between strains in future pre-clinical efficacy studies of traumatic brain injury.
Tan
Arlene A
AA
Restorative Neuroscience Laboratory, Brain and Cognitive Sciences Program, Department of Psychology, Southern Illinois University, Carbondale, Illinois 62901, USA.
Quigley
Andrea
A
Smith
Douglas C
DC
Hoane
Michael R
MR
D000818:Animals; D021461:Animals, Outbred Strains / Q000502:physiology; D001049:Apnea / Q000209:etiology; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology*; D001930:Brain Injuries / Q000150:complications / Q000473:pathology* / Q000503:physiopathology*; D003072:Cognition Disorders / Q000209:etiology / Q000503:physiopathology; D004195:Disease Models, Animal; D007839:Functional Laterality / Q000502:physiology; D008297:Male; D009410:Nerve Degeneration / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology; D013045:Species Specificity; D014474:Unconsciousness / Q000209:etiology