title: Disease confined within the ovary and smaller amount of ascites are good prognostic factors for survival of patients with squamous cell carcinoma arising from mature cystic teratoma of the ovary: a case series in Korea and review of the published reports.
abstract: OBJECTIVE
  To identify clinical prognostic factors for survival of patients with squamous cell carcinoma (SqCC) arising from mature cystic teratoma (MCT) of the ovary with review of the published reports.
  
  
  METHODS
  Clinical data of 55 patients with SqCC arising from MCT of the ovary who were reported in the Korean Journal of Obstetrics and Gynecology and the Korean Journal of Gynecologic Oncology and Colposcopy between 1992 and 2006 were reviewed. Clinical factors were analyzed to identify their association with disease-free survival and overall survival (OS), which were evaluated using the Kaplan-Meier analysis with the log-rank test. Clinical prognostic factors were identified using Cox's proportional hazard analysis.
  
  
  RESULTS
  Patients with disease confined within the ovary (n = 31) or ascites <500 mL (n = 15) had the benefit of a higher mean OS than those with advanced disease (n = 8) (116 vs 21 months, P = 0.004) and ascites > or =500 mL (n = 7) (106 vs 8 months, P = 0.005), respectively. Disease confined within the ovary and ascites <500 mL were good prognostic factors by univariate but not multivariate Cox's proportional hazard analyses (HR = 0.123 and 0.139, 95% confidence interval = 0.022-0.670 and 0.027-0.722, respectively).
  
  
  CONCLUSIONS
  Disease confined within the ovary and a smaller amount of ascites may be good prognostic factors for the OS of patients with SqCC arising from MCT of the ovary.
authors.affiliation: Department of Obstetrics and Gynecology, Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hee Seung
authors.initials: HS
authors.lastname: Kim
authors.forename: Jae Weon
authors.initials: JW
authors.lastname: Kim
authors.forename: Hyun Hoon
authors.initials: HH
authors.lastname: Chung
authors.forename: Noh-Hyun
authors.initials: NH
authors.lastname: Park
authors.forename: Yong-Sang
authors.initials: YS
authors.lastname: Song
authors.forename: Soon-Beom
authors.initials: SB
authors.lastname: Kang
mesh_terms: D001201:Ascites / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*; D012189:Retrospective Studies; D013724:Teratoma / Q000473:pathology*