[Anticytokine therapy in sepsis and why it fails].
Anticytokine therapy in sepsis belongs to a subgroup of therapeutic interventions referred to as antiinflammatory or immunomodulatory strategies in the intensive care literature. Between the mid-1980s and the late 1990s, this approach was considered very promising. Against all expectations, it proved ineffective or even harmful in many cases. However, the recent literature is suggestive of a renewed interest in the topic. Therefore, we attempted at a retrospective search for causes of the failure.
Chýlek
Václav
V
Dept. of Anaesthesiology and Resuscitation, University Hospital Ostrava, Czech Republic. Vaclav.Chylek@seznam.cz
Kula
Roman
R
Holub
Michal
M
Szturz
Pavel
P
Sklienka
Peter
P
Máca
Jan
J
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D016207:Cytokines / Q000276:immunology* / Q000502:physiology; D006801:Humans; D018805:Sepsis / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology
D000911:Antibodies, Monoclonal; D016207:Cytokines