title: [Comparative study for the treatment of erectile dysfunction with sildenafil and vardenafil--multi-centric research in Nagano City].
abstract: OBJECTIVE
  The efficacy and safety of two types of phoshodiestrase type 5 ( PDE 5) inhibitors (sildenafil (sil) and vardenafil (var)) were investigated for multi-centric study.
  
  
  METHODS
  One hundred and twenty five patients (55.9 +/- 10.9 years old) with erectile dysfunction (ED) were treated by both of sil and var. The patients were administered a pair of 25 mg of sil and 5 mg of var, or 50 mg of sil and 10 mg of var. The efficacy for ED and safety of these 2 drugs were evaluated after administration of each drugs at least 2 times.
  
  
  RESULTS
  The results showed that the score of international index of erectile function 5 (IIEF5) were elevated from 8.87 +/- 4.10 to 17.24 +/- 6.17 after treatments (p< 0.0001, Student' s t test). The efficacy rates for ED were 81.6% in sil and 81.6% in var, respectively. The adverse reactions rates such as headache, burning, palpitation, etc. were 13.6% in sil and 5.6% in var, which is significantly higher in sil (p = 0.032; chi2 test). These side effects were not serious at all, and there were no cases that gave up to use PDE5 inhibitors because of adverse reactions. According to individual patients experiences, 40.7% of patients preferred sil, 45.4% choose var. In addition, associated effects for quality of life (QOL) of ED patients treated by PDE5 inhibitors were analyzed. The results revealed that encouraging in life 46.5%, rejuvenation feeling 45.1%, self care for their health 28.2%, improvement of depression 12.7%, improvement of voiding dysfunction 5.6%, intimacy with partner 38.0%, good conversation with partner 18.3%, and so on.
  
  
  CONCLUSIONS
  The treatments of ED by sil and var were very effective and safety. Furthermore, associated effects for QOL of ED patients were also improved with these treatments.
authors.affiliation: Department of Urology, Nagano Red Cross Hospital.
authors.forename: Amano
authors.initials: A
authors.lastname: Toshiyasu
authors.forename: Imao
authors.initials: I
authors.lastname: Tetsuya
authors.forename: Takemae
authors.initials: T
authors.lastname: Katsurou
authors.forename: Wajiki
authors.initials: W
authors.lastname: Masahisa
authors.forename: Tsuruta
authors.initials: T
authors.lastname: Takashi
authors.forename: Suzuki
authors.initials: S
authors.lastname: Naonori
authors.forename: Ueno
authors.initials: U
authors.lastname: Youko
authors.forename: Okaneya
authors.initials: O
authors.lastname: Toshikazu
authors.forename: Nishizawa
authors.initials: N
authors.lastname: Shuji
authors.forename: Minagaw
authors.initials: M
authors.lastname: Michinori
authors.forename: Nakayama
authors.initials: N
authors.lastname: Takeshi
authors.forename: Kamigaito
authors.initials: K
authors.lastname: Takayuki
authors.forename: Nakagawa
authors.initials: N
authors.lastname: Tatsuo
authors.forename: Suzuki
authors.initials: S
authors.lastname: Tomio
authors.forename: Asai
authors.initials: A
authors.lastname: Makoto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takamizawa
mesh_terms: D000328:Adult; D000368:Aged; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage* / Q000009:adverse effects; D007564:Japan; D008297:Male; D008875:Middle Aged; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D010879:Piperazines / Q000008:administration & dosage* / Q000009:adverse effects; D011687:Purines / Q000008:administration & dosage / Q000009:adverse effects; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects; D000069058:Vardenafil Dihydrochloride
chemical_list: D007093:Imidazoles; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014227:Triazines; D000069058:Vardenafil Dihydrochloride; D000068677:Sildenafil Citrate