title: Impaired theta phase-resetting underlying auditory N1 suppression in chronic alcoholism.
abstract: It has been suggested that chronic alcoholism may lead to altered neural mechanisms related to inhibitory processes. Here, we studied auditory N1 suppression phenomena (i.e. amplitude reduction with repetitive stimuli) in chronic alcoholic patients as an early-stage information-processing brain function involving inhibition by the analysis of the N1 event-related potential and time-frequency computation (spectral power and phase-resetting). Our results showed enhanced neural theta oscillatory phase-resetting underlying N1 generation in suppressed N1 event-related potential. The present findings suggest that chronic alcoholism alters neural oscillatory synchrony dynamics at very early stages of information processing.
authors.affiliation: Neurodynamics Laboratory, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Spain.
authors.forename: Lluis
authors.initials: L
authors.lastname: Fuentemilla
authors.forename: Josep
authors.initials: J
authors.lastname: Marco-Pallarés
authors.forename: Antoni
authors.initials: A
authors.lastname: Gual
authors.forename: Carles
authors.initials: C
authors.lastname: Escera
authors.forename: Maria Dolores
authors.initials: MD
authors.lastname: Polo
authors.forename: Carles
authors.initials: C
authors.lastname: Grau
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D020268:Alcohol-Induced Disorders, Nervous System / Q000503:physiopathology*; D000437:Alcoholism / Q000150:complications / Q000503:physiopathology*; D001307:Auditory Perception / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002492:Central Nervous System Depressants / Q000009:adverse effects; D002908:Chronic Disease; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology*; D004569:Electroencephalography; D000431:Ethanol / Q000009:adverse effects; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D055139:Sensory Gating / Q000187:drug effects / Q000502:physiology*; D013826:Theta Rhythm / Q000187:drug effects*
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol