title: Oseltamivir-resistant influenza viruses A (H1N1), Norway, 2007-08.
abstract: In Norway in January 2008, unprecedented levels of oseltamivir resistance were found in 12 of 16 influenza viruses A (H1N1) tested. To investigate the epidemiologic and clinical characteristics of these viruses, we used sequence analysis to test all available subtype H1N1 viruses from the 2007-08 season for resistance. Questionnaires from physicians provided information on predisposing diseases, oseltamivir use, symptoms, and complications. Clinical data were obtained for 265 patients. In total, 183 (67.3%) of 272 viruses were oseltamivir resistant. Resistance was not associated with prior use of antiviral drugs. Symptoms and hospitalization rates did not differ for patients infected with a resistant or a susceptible virus. Oseltamivir-resistant influenza viruses A (H1N1) did not show diminished capability to spread in the absence of selective pressure. The ability of these viruses to sustain their fitness and spread among persons should be considered when shaping future strategies for treating and preventing seasonal and pandemic influenza.
authors.affiliation: Norwegian Institute of Public Health, Oslo, Norway.
authors.forename: Siri H
authors.initials: SH
authors.lastname: Hauge
authors.forename: Susanne
authors.initials: S
authors.lastname: Dudman
authors.forename: Katrine
authors.initials: K
authors.lastname: Borgen
authors.forename: Angie
authors.initials: A
authors.lastname: Lackenby
authors.forename: Olav
authors.initials: O
authors.lastname: Hungnes
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D024882:Drug Resistance, Viral; D006801:Humans; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D007251:Influenza, Human / Q000453:epidemiology* / Q000821:virology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D053139:Oseltamivir / Q000494:pharmacology*; D011159:Population Surveillance; D012621:Seasons; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir