title: Salmonella encephalopathy successfully treated with high-dose methylpredonisolone therapy.
abstract: We present a 7-year-old boy diagnosed as having salmonella encephalopathy. He developed severe consciousness disturbance following enterocolitis. Electroencephalography showed diffuse and high-voltage slow activity but MR images of the brain were normal. Examination of inflammatory cytokines in serum and cerebrospinal fluid revealed high levels of interleukin-6, -8, and -10, and interferon gamma. Salmonella typhimurium was detected in a stool specimen. He was diagnosed as having salmonella-associated encephalopathy that had features of septic encephalopathy and quickly responded to high-dose methylpredonisolone therapy. High-dose methylpredonisolone was considered to be an effective treatment for hypercytokine-mediated S. encephalopathy.
authors.affiliation: Department of Pediatrics, Yokohama City University Medical Center, 4-57 Urafune-cho, Minami-ku, Yokohama 232-0024, Japan. k-ichi@urahp.yokohama-cu.ac.jp
authors.forename: Kazushi
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Akiko
authors.initials: A
authors.lastname: Kajitani
authors.forename: Akiko
authors.initials: A
authors.lastname: Tsutsumi
authors.forename: Saoko
authors.initials: S
authors.lastname: Takeshita
mesh_terms: D002648:Child; D004569:Electroencephalography; D004660:Encephalitis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007564:Japan; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D012480:Salmonella Infections / Q000150:complications / Q000188:drug therapy*; D012486:Salmonella typhimurium
chemical_list: D008775:Methylprednisolone