The heme oxygenase-1 genotype is a risk factor to renal impairment of IgA nephropathy at diagnosis, which is a strong predictor of mortality.
The induction of heme oxygenase-1 (HO-1) ameliorates oxidative stress and inflammatory process, which play important roles in IgA nephropathy. We hypothesized length polymorphism in the promoter region of the HO-1 gene, which is related to the level of gene transcription, is associated with disease severity of IgA nephropathy. The subjects comprised 916 patients with IgA nephropathy and gene data. Renal impairment was defined as an estimated glomerular filtration rate less than 60 mL/min/1.73 m(2) at diagnosis. The short (S: <23), medium (M: 23-28), and long (L: >28) (GT) repeats in the HO-1 gene was determined. The frequencies of S/S, S/M, M/M, S/L, L/M, and L/L genotypes were 7.2%, 6.9%, 3.1%, 30.8%, 22.7%, and 29.4%, respectively. The baseline characteristics were not different. In the S/S genotypic group, the renal impairment rate was 18.2%, which was lower than 32.2% in the group with M/M, L/M, or L/L genotype. The odds ratio of renal impairment in S/S genotype, compared to that in M/M, L/M, or L/L genotype, was 0.216 (95% confidence interval, 0.060-0.774, p=0.019). The HO-1 gene promoter length polymorphism was related to the renal impairment of IgA nephropathy at diagnosis, which is an important risk factor for mortality in IgA nephropathy patients.
Chin
Ho Jun
HJ
Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Cho
Hyun Jin
HJ
Lee
Tae Woo
TW
Na
Ki Young
KY
Yoon
Hyung Jin
HJ
Chae
Dong-Wan
DW
Kim
Suhnggwon
S
Jeon
Un Sil
US
Do
Jun-Young
JY
Park
Jong-Won
JW
Yoon
Kyung-Woo
KW
Shin
Young-Tai
YT
Lee
Kang Wook
KW
Na
Ki-Ryang
KR
Cha
Dae Ryong
DR
Kang
Young Sun
YS
D000328:Adult; D018450:Disease Progression; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005919:Glomerular Filtration Rate; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000401:mortality / Q000473:pathology*; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors
D051547:Heme Oxygenase-1