Effect of two behavioral tests on corticosterone level in plasma of mice lacking the noradrenaline transporter.
In the present study, we investigated plasma corticosterone levels of genetically modified mice lacking noradrenaline transporter (NET(-/-)), in response to the forced swim test (FST) and tail suspension test (TST). FST strongly increased the plasma corticosterone level in the first minute after the test (significantly only in NET(+/+) mice), while TST was without any significant effect in both genotypes studied. A single dose of tianeptine (20 mg/kg, ip) shortened immobility time in both tests in NET(-/-) mice, as well as NET(+/+) mice subjected to FST, but not TST. The lack of effect of tianeptine in control animals (NET(+/+)) subjected to TST is also reflected in unchanged levels of plasma corticosterone.
Solich
Joanna
J
Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. solich@if-pan.krakow.pl
Pałach
Paulina
P
Budziszewska
Bogusława
B
Dziedzicka-Wasylewska
Marta
M
D000818:Animals; D003345:Corticosterone / Q000097:blood*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000502:physiology*; D013550:Swimming; D013841:Thiazepines / Q000494:pharmacology
D050484:Norepinephrine Plasma Membrane Transport Proteins; D013841:Thiazepines; C050504:tianeptine; D010134:Fenclonine; D003345:Corticosterone