Balancing out the ends during iPSC nuclear reprogramming.
In this issue of Cell Stem Cell, Marion et al. (2009) report that efficient production of iPSCs requires active telomerase, which allows the rejuvenation of telomeres to a state similar to that observed in embryonic stem cells, even in iPSCs generated from old donor cells.
Davy
Phil
P
Institute for Biogenesis Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96183, USA.
Allsopp
Richard
R
D000818:Animals; D065150:Cellular Reprogramming / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D039904:Pluripotent Stem Cells / Q000502:physiology*; D019098:Telomerase / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism*
D019098:Telomerase