title: External beam radiation therapy enhances local control in pigmented villonodular synovitis.
abstract: OBJECTIVE
  Pigmented villonodular synovitis (PVNS) is a rare proliferative disorder of the synovium with locally aggressive behavior. We reviewed our experience using radiation therapy in the treatment of PVNS.
  
  
  METHODS
  Seventeen patients with 18 sites of PVNS were treated with radiation between 1993 and 2007. Cases were retrospectively reviewed for patient information, treatment parameters, complications, and outcome. Seven sites were primary presentations and 11 were recurrent with an average of 2.5 prior surgical interventions. The most common location was the knee joint (67%). Cytoreductive surgery was performed before radiation therapy in 16/18 sites with all having proven or suspected residual disease. Radiation was delivered using 4-15 MV photons with an average total dose 34 Gy (range, 20-36 Gy). Seventeen of 18 sites (94%) had postradiotherapy imaging.
  
  
  RESULTS
  With average follow-up of 46 months (range, 8-181 months), initial local control was achieved in 75% (12/16) of the sites with prior cytoreductive surgery (mean time to recurrence, 38 months). Ultimate local control was 100% after repeat resection (mean follow-up, 61 months). Two additional sites without prior cytoreductive surgery showed growth after radiotherapy (mean time to documented growth, 10.5 months). Seventeen of the 18 involved joints (94%) were scored as excellent or good PVNS-related function, one site (5%) as fair function, and no site with poor function. No patient required amputation; and there were no Grade 3/4 treatment-related complications.
  
  
  CONCLUSIONS
  Postoperative external beam radiation is effective in preventing disease recurrence and should be offered following maximal cytoreduction to enhance local control in PVNS.
authors.affiliation: Department of Radiation Oncology, Stanford Cancer Center, Stanford School of Medicine, Stanford, CA, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Horoschak
authors.forename: Phuoc T
authors.initials: PT
authors.lastname: Tran
authors.forename: Pavan
authors.initials: P
authors.lastname: Bachireddy
authors.forename: Robert B
authors.initials: RB
authors.lastname: West
authors.forename: David
authors.initials: D
authors.lastname: Mohler
authors.forename: Christopher F
authors.initials: CF
authors.lastname: Beaulieu
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Kapp
authors.forename: Sarah S
authors.initials: SS
authors.lastname: Donaldson
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D013586:Synovitis, Pigmented Villonodular / Q000532:radiotherapy*; D055815:Young Adult