title: New susceptibility locus for coronary artery disease on chromosome 3q22.3.
abstract: We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).
authors.affiliation: Medizinische Klinik II, Universität zu Lübeck, 23538 Lübeck, Germany. j.erdmann@cardiogenics.eu
authors.forename: Jeanette
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authors.lastname: Erdmann
authors.forename: Anika
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authors.lastname: Grosshennig
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authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Christian
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authors.lastname: Hengstenberg
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authors.lastname: Hall
authors.forename: Patrick
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authors.lastname: Kathiresan
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authors.forename: David-Alexandre
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authors.lastname: Trégouët
authors.forename: Francois
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authors.lastname: Cambien
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authors.lastname: Bruse
authors.forename: Zouhair
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authors.lastname: Aherrahrou
authors.forename: Arnika K
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authors.lastname: Wagner
authors.forename: Klaus
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authors.forename: Stephen M
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authors.lastname: Schwartz
authors.forename: Veikko
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authors.lastname: Salomaa
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authors.lastname: Peltonen
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authors.lastname: Siscovick
authors.forename: David
authors.initials: D
authors.lastname: Altshuler
authors.forename: Piera Angelica
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authors.lastname: Merlini
authors.forename: Flora
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authors.lastname: Peyvandi
authors.forename: Luisa
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authors.lastname: Bernardinelli
authors.forename: Diego
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authors.lastname: Ardissino
authors.forename: Arne
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authors.lastname: Blankenberg
authors.forename: Tanja
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authors.lastname: Zeller
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authors.lastname: Wild
authors.forename: Daniel F
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authors.lastname: Schwarz
authors.forename: Laurence
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authors.lastname: Tiret
authors.forename: Claire
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authors.lastname: Perret
authors.forename: Stefan
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authors.lastname: Schreiber
authors.forename: Nour Eddine
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authors.lastname: El Mokhtari
authors.forename: Arne
authors.initials: A
authors.lastname: Schäfer
authors.forename: Winfried
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authors.lastname: März
authors.forename: Wilfried
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authors.lastname: Renner
authors.forename: Peter
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authors.lastname: Bugert
authors.forename: Harald
authors.initials: H
authors.lastname: Klüter
authors.forename: Jürgen
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authors.lastname: Schrezenmeir
authors.forename: Diana
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authors.lastname: Rubin
authors.forename: Stephen G
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authors.lastname: Ball
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Balmforth
authors.forename: H-Erich
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authors.lastname: Wichmann
authors.forename: Thomas
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authors.lastname: Meitinger
authors.forename: Marcus
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authors.lastname: Fischer
authors.forename: Christa
authors.initials: C
authors.lastname: Meisinger
authors.forename: Jens
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authors.lastname: Baumert
authors.forename: Annette
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authors.lastname: Peters
authors.forename: Willem H
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authors.lastname: Ouwehand
authors.forename: Panos
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authors.lastname: Deloukas
authors.forename: John R
authors.initials: JR
authors.lastname: Thompson
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Nilesh J
authors.initials: NJ
authors.lastname: Samani
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
mesh_terms: D016022:Case-Control Studies; D002893:Chromosomes, Human, Pair 3; D003324:Coronary Artery Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005858:Germany; D051538:Hepatocyte Nuclear Factor 1-alpha / Q000235:genetics; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D018631:ras Proteins / Q000235:genetics
chemical_list: C496487:HNF1A protein, human; D051538:Hepatocyte Nuclear Factor 1-alpha; C109523:MRAS protein, human; D018631:ras Proteins