Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome.
PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, adenitis) is a benign sporadic syndrome of unknown cause. We report 2 siblings diagnosed with this syndrome. The second case started crisis simultaneously with recurrence of crisis after a 3-year free interval in her brother. This temporal relation suggests environmental factor acting in genetically predisposed children.
Sampaio
Isabel Cristina Ramos Melo
IC
Pediatrics Department, Infectious Disease Division, Hospital Santa Maria, Lisboa, Portugal. i_sampaio@yahoo.com
Rodrigo
Maria João
MJ
Monteiro Marques
José Gonçalo Duque Pereira
JG
D002648:Child; D002675:Child, Preschool; D005260:Female; D005335:Fever of Unknown Origin / Q000150:complications* / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008199:Lymphadenitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D010507:Periodicity; D010612:Pharyngitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D035781:Siblings; D013281:Stomatitis, Aphthous / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D013577:Syndrome
D005938:Glucocorticoids; D011241:Prednisone