title: [Genes associated with tobacco smoke-associated cancer of head and neck].
abstract: The article presents the current techniques used for the identification of genes involved in tobacco smoke-associated cancers. The focus is set on the techniques derived from the conventional cytogenetics and includes fluorescence in situ hybridization (FISH), comparative genomes hybridization (CGH) and its further improvement that is array-CGH, and other aspects of microarray DNA technology. The second part deals with the main findings concerning participation of oncogenes and tumor suppressor genes in development and progression of tobacco smoke-associated head and neck cancers.
authors.affiliation: Instytut Genetyki Człowieka PAN w Poznaniu. szyfkris@man.poznan.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szyfter
authors.forename: Maciej
authors.initials: M
authors.lastname: Giefing
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Jarmuz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Kostrzewska-Poczekaj
mesh_terms: D000328:Adult; D000368:Aged; D015984:Causality; D015897:Comorbidity; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000502:physiology; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D009857:Oncogenes / Q000502:physiology; D012907:Smoking / Q000453:epidemiology*