Ubiquitination of Myc: proteasomal degradation and beyond.
The level of Myc proteins is a critical determinant of cellular proliferation and apoptosis. Ubiquitination of Myc plays a key role in controlling protein levels by stimulating proteasomal degradation of the protein. Some experiments suggest that ubiquitination may also regulate Myc function in addition to turnover. This review attempts to summarize current knowledge about this field.
Müller
J
J
Institute of Molecular Biology and Tumor Research, Philipps-University Marburg, Marburg, Germany.
Eilers
M
M
D000818:Animals; D001963:Bromelains / Q000378:metabolism*; D006801:Humans; D016274:Oncogene Protein p55(v-myc) / Q000235:genetics / Q000378:metabolism*; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D054875:Ubiquitination
D016274:Oncogene Protein p55(v-myc); D016271:Proto-Oncogene Proteins c-myc; D001963:Bromelains; D044767:Ubiquitin-Protein Ligases