title: Lipid peroxidation products formation with various intravenous iron preparations in chronic kidney disease.
abstract: The role of intravenous iron in contributing to oxidative stress and endothelial dysfunction in chronic kidney disease (CKD) is debatable. The present study assessed differences in fasting plasma malondialdehyde (pMDA) levels 30 minutes before and after intravenous infusion of low molecular weight iron dextran (ID) (n = 19), iron-sucrose (IS) (n = 20), and sodium ferrigluconate complex (SFGC) (n = 20) in stage 3 and 4 CKD patients. Post-infusion pMDA levels were significantly raised with respect to baseline (p < 0.001). pMDA was significantly higher in the SFGC group vs. IS (3.02 +/- 0.84 micromol/L vs. 2.82 +/- 0.44 micromol/L, p = 0.034) or SFGC vs. ID (3.02 +/- 0.84 micromol/L vs. 2.92 +/- 0.20 micromol/L, p = 0.048). There was no difference between IS vs. ID (2.82 +/- 0.44 micromol/L vs. 2.92 +/- 0.20 micromol/L, p = 0.21). To conclude, all forms of parenteral iron, especially SFGC, significantly raise pMDA levels in the immediate post-transfusion period.
authors.affiliation: Department of Nephrology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Anirban
authors.initials: A
authors.lastname: Ganguli
authors.forename: Harbir Singh
authors.initials: HS
authors.lastname: Kohli
authors.forename: Madhu
authors.initials: M
authors.lastname: Khullar
authors.forename: Krishan
authors.initials: K
authors.lastname: Lal Gupta
authors.forename: Vivekanand
authors.initials: V
authors.lastname: Jha
authors.forename: Vinay
authors.initials: V
authors.lastname: Sakhuja
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000150:complications; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged
chemical_list: D005290:Ferric Compounds; D008315:Malondialdehyde