title: Outcome of hepaticojejunostomy for biliary tract obstruction following liver transplantation.
abstract: BACKGROUND
  Strictures and concrements are the most common biliary complications following liver transplantation. Endoscopic treatment might not lead to a definitive cure in all patients, especially in strictures involving the biliary bifurcation. The aim of this study was to determine the efficacy and the long-term outcome of hepaticojejunostomy (HJS) for post-transplant biliary tract obstruction.
  
  
  METHODS
  Thirty-seven patients were retrospectively studied for resolving of cholestasis and the incidence of recurring biliary obstruction.
  
  
  RESULTS
  Surgery was performed because of anastomotic strictures in 11, ischemic strictures at the donor common bile duct in seven, strictures involving the bile duct bifurcation in 10, hepatolithiasis without strictures in one and biliary cast formation diagnosed by endoscopic retrograde cholangiography or T-tube cholangiography in eight patients. Cholestasis instantly improved in 82% of the patients. After a long-term follow-up of median 33 months (range 3-149), 28 of the patients (76%) required no further intervention for recurring biliary obstruction following HJS. Anastomotic strictures were observed in six (16%), recurring biliary concrements in two patients (5%).
  
  
  CONCLUSIONS
  HJS did prevent recurrent biliary obstruction in the majority of the patients. We therefore recommend early HJS for complicated post-transplant biliary tract obstruction not treatable by a limited number of endoscopic interventions.
authors.affiliation: Division for Transplantation, Department of Surgery, Medical University Vienna, Vienna, Austria. felix.langer@meduniwien.ac.at
authors.forename: F B
authors.initials: FB
authors.lastname: Langer
authors.forename: G P
authors.initials: GP
authors.lastname: Györi
authors.forename: H
authors.initials: H
authors.lastname: Pokorny
authors.forename: C
authors.initials: C
authors.lastname: Burghuber
authors.forename: S
authors.initials: S
authors.lastname: Rasoul-Rockenschaub
authors.forename: G A
authors.initials: GA
authors.lastname: Berlakovich
authors.forename: F
authors.initials: F
authors.lastname: Mühlbacher
authors.forename: R
authors.initials: R
authors.lastname: Steininger
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D001660:Biliary Tract Diseases / Q000209:etiology / Q000601:surgery*; D002768:Choledochostomy / Q000009:adverse effects; D005260:Female; D006500:Hepatic Duct, Common / Q000601:surgery*; D006801:Humans; D007583:Jejunum / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055502:Secondary Prevention; D055815:Young Adult