[Mannose-binding lectin and mortality in patients with type 2 diabetes mellitus--secondary publication].
We evaluated the relationship between serum mannose-binding lectin (MBL) and mortality and incident albuminuria in 326 patients with type 2 diabetes mellitus (T2DM). During 15 years of follow-up, 169 patients died. In a multivariate analysis, MBL was a significant risk factor for death from any cause and added to the predictive power of CRP. Normoalbuminuric patients with both high MBL and high C-reactive protein (CRP) levels had a significantly increased risk of developing albuminuria. We conclude that MBL alone or in combination with CRP can provide prognostic information on mortality and the development of albuminuria in T2DM
Hansen
Troels Krarup
TK
Immunendokrinologisk Forskningsenhed, Medicinsk Afdeling M, Arhus Sygehus. tkh@dadlnet.dk
Gall
Mari-Anne
MA
Tarnow
Lise
L
Thiel
Steffen
S
D000419:Albuminuria / Q000209:etiology; D002097:C-Reactive Protein / Q000032:analysis; D015331:Cohort Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood*; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors
D037601:Mannose-Binding Lectin; D002097:C-Reactive Protein