title: Narrowband magnetic particle imaging.
abstract: The magnetic particle imaging (MPI) method directly images the magnetization of super-paramagnetic iron oxide (SPIO) nanoparticles, which are contrast agents commonly used in magnetic resonance imaging (MRI). MPI, as originally envisioned, requires a high-bandwidth receiver coil and preamplifier, which are difficult to optimally noise match. This paper introduces Narrowband MPI, which dramatically reduces bandwidth requirements and increases the signal-to-noise ratio for a fixed specific absorption rate. We employ a two-tone excitation (called intermodulation) that can be tailored for a high-Q, narrowband receiver coil. We then demonstrate a new MPI instrument capable of full 3-D tomographic imaging of SPIO particles by imaging acrylic and tissue phantoms.
authors.affiliation: UCSF/UC Berkeley Joint Graduate Group in Bioengineering, University of California, Berkeley, CA 94720, USA. goodwill@berkeley.edu
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Goodwill
authors.forename: Greig C
authors.initials: GC
authors.lastname: Scott
authors.forename: Pascal P
authors.initials: PP
authors.lastname: Stang
authors.forename: Steven M
authors.initials: SM
authors.lastname: Conolly
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D005290:Ferric Compounds / Q000737:chemistry*; D008099:Liver / Q000033:anatomy & histology; D008280:Magnetics; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry*; D019047:Phantoms, Imaging; D014054:Tomography / Q000379:methods*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide