Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women.
The objective of the present study was to determine the potential long-term impact of dietary habits on age-related decline among 4809 elderly women (born between 1925 and 1930) in the 'Etude Epidémiologique de Femmes de la Mutuelle Générale de l'Education Nationale' (E3N) study, a French epidemiological cohort. In 1993, an extensive diet history self-administered questionnaire was sent to all participants, and in 2006 another questionnaire on instrumental activities of daily living (IADL) and recent cognitive change was sent to a close relative or friend of each woman. Logistic models adjusted for socio-demographic, lifestyle and health factors were performed to evaluate associations between habitual dietary intakes and two outcomes of interest based on the informant response: recent cognitive decline and IADL impairment. Recent cognitive decline was associated with lower intakes of poultry, fish, and animal fats, as well as higher intakes of dairy desserts and ice-cream. IADL impairment was associated with a lower intake of vegetables. The odds of recent cognitive decline increased significantly with decreasing intake of soluble dietary fibre and n-3 fatty acids but with increasing intake of retinol. The odds of IADL impairment increased significantly with decreasing intakes of vitamins B2, B6 and B12. These results are consistent with a possible long-term neuroprotective effect of dietary fibre, n-3 polyunsaturated fats and B-group vitamins, and support dietary intervention to prevent cognitive decline.
Vercambre
Marie-Noël
MN
Institut National de la Santé et de la Recherche Médicale, ERI 20, EA 4045, and Institut Gustave Roussy, Villejuif, France.
Boutron-Ruault
Marie-Christine
MC
Ritchie
Karen
K
Clavel-Chapelon
Françoise
F
Berr
Claudine
C
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003072:Cognition Disorders / Q000517:prevention & control* / Q000523:psychology; D004032:Diet; D004034:Diet Surveys; D004043:Dietary Fiber / Q000008:administration & dosage; D004522:Educational Status; D002149:Energy Intake; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D016015:Logistic Models; D008393:Marriage; D014675:Vegetables; D014803:Vitamin B Complex / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage
D004043:Dietary Fiber; D015525:Fatty Acids, Omega-3; D014815:Vitamins; D014803:Vitamin B Complex