title: Diterpene formamides from the tropical marine sponge Cymbastela hooperi and their antimalarial activity in vitro.
abstract: Further investigations of the VLC (vacuum-liquid chromatography) fractions obtained from the dichloromethane solubles of the tropical marine sponge Cymbastela hooperi led to the isolation and characterization of five new diterpene formamides, 1-5. Compound 1 is one of the very few examples of a natural product that contains both formamide and isonitrile functionalities within the same molecule. In in vitro antiplasmodial bioassays, 1 was found to have moderate activity (IC(50) 0.5 microg/mL), 2 had weak activity (IC(50) 14.8 microg/mL), and 3-5 were inactive. The pattern of activity found for the metabolites investigated in the current study is consistent with previous findings for these classes of molecules.
authors.affiliation: College of Pharmacy, University of Hawaii at Hilo, Hilo, Hawaii 96720, USA. adwright@hawaii.edu
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wright
authors.forename: Naomi
authors.initials: N
authors.lastname: Lang-Unnasch
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005559:Formamides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D008386:Marine Biology; D015394:Molecular Structure; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000962:Antimalarials; D004224:Diterpenes; D005559:Formamides