title: Isolated Whipple disease of the brain resembling a tumour.
abstract: BACKGROUND
  Isolated Whipple disease of the central nervous system is a rare occurrence. Migratory arthralgias and gastrointestinal problems, including malabsorption, abdominal pain, diarrhea, and weight loss, are common presenting symptoms.
  
  
  CONCLUSIONS
  For those patients with systemic signs and symptoms of Whipple disease, 6% to 43% will have clinically manifested CNS involvement that may include alterations in personality, ataxia, and dementia. We report our experience with a patient, who was successfully treated for Whipple disease 12 years prior to presentation and had a magnetic resonance image of the brain that revealed two solitary lesions resembling a tumor upon presentation.
authors.affiliation: Department of Neurosurgery and Oncology, The Johns Hopkins Neuro-Oncology Surgical Outcomes Research Laboratory, Johns Hopkins School of Medicine, Baltimore, MD, 21231, USA.
authors.forename: James L
authors.initials: JL
authors.lastname: Frazier
authors.forename: Alfredo
authors.initials: A
authors.lastname: Quinones-Hinojosa
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000175:diagnosis; D002908:Chronic Disease / Q000628:therapy; D003244:Consciousness Disorders / Q000209:etiology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors / Q000517:prevention & control*; D004660:Encephalitis / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery; D006261:Headache / Q000209:etiology; D006801:Humans; D007031:Hypothalamus / Q000382:microbiology / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D013702:Temporal Lobe / Q000382:microbiology* / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use; D054851:Tropheryma / Q000502:physiology; D008061:Whipple Disease / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination