title: Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds.
abstract: Conditions for the palladium-catalyzed direct arylation of a wide range of heterocycles with aryl bromides are reported. Those conditions employ a stoichiometric ratio of both coupling partners, as well as a substoichiometric quantity of pivalic acid, which results in significantly faster reactions. An evaluation of the influence of the nature of the aryl halide has also been carried out.
authors.affiliation: Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6N5, Canada.
authors.forename: Benoît
authors.initials: B
authors.lastname: Liégault
authors.forename: David
authors.initials: D
authors.lastname: Lapointe
authors.forename: Laurence
authors.initials: L
authors.lastname: Caron
authors.forename: Anna
authors.initials: A
authors.lastname: Vlassova
authors.forename: Keith
authors.initials: K
authors.lastname: Fagnou
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D006571:Heterocyclic Compounds; D006842:Hydrocarbons, Brominated; D010165:Palladium