title: Tyrokeradines A and B, new bromotyrosine alkaloids with an imidazolyl-quinolinone moiety from a verongid sponge.
abstract: Two new bromotyrosine alkaloids, tyrokeradines A (1) and B (2), with an imidazolyl-quinolinone moiety have been isolated from an Okinawan marine sponge of the order Verongida. The structures of 1 and 2 were elucidated on the basis of spectroscopic data.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
authors.forename: Hiroya
authors.initials: H
authors.lastname: Mukai
authors.forename: Takaaki
authors.initials: T
authors.lastname: Kubota
authors.forename: Kazuki
authors.initials: K
authors.lastname: Aoyama
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Mikami
authors.forename: Jane
authors.initials: J
authors.lastname: Fromont
authors.forename: Jun'ichi
authors.initials: J
authors.lastname: Kobayashi
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D007093:Imidazoles / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera; D015363:Quinolones / Q000302:isolation & purification* / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D007093:Imidazoles; D015363:Quinolones; C475724:bromotyrosine; D014443:Tyrosine