Antihypertensive effects and endothelial progenitor cell activation by intake of chicken collagen hydrolysate in pre- and mild-hypertension.
Chicken collagen hydrolysate was given to 15 mildly hypertensive subjects for 4 weeks. Blood pressure was significantly decreased by 11.8 mmHg (P<0.01). A reduction in plasma renin activity was observed in blood test after intake. A colony assay of endothelial progenitor cells in blood samples from non-smokers revealed an approximately 30% increase in the number of colonies.
Saiga-Egusa
Ai
A
R&D Center, Nippon Meat Packers, Inc., Tsukuba, Ibaraki, Japan. a.egusa@nipponham.co.jp
Iwai
Koji
K
Hayakawa
Toru
T
Takahata
Yoshihisa
Y
Morimatsu
Fumiki
F
D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002645:Chickens; D003094:Collagen / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D004727:Endothelium / Q000166:cytology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011492:Protein Hydrolysates / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D000959:Antihypertensive Agents; D011492:Protein Hydrolysates; D003094:Collagen