title: Medical procedures and risk for sporadic Creutzfeldt-Jakob disease, Japan, 1999-2008.
abstract: To elucidate the association between medical procedures and sporadic Creutzfeldt-Jakob disease (sCJD), we analyzed medical procedures (any surgical procedure, neurosurgery, ophthalmic surgery, and blood transfusion) for patients registered by the CJD Surveillance Committee in Japan during 1999-2008. We conducted an age-stratified case-control study with 753 sCJD patients and 210 controls and a study of patients who underwent neurosurgical or ophthalmic surgical procedures at the same hospital. Although the control group was relatively small, no evidence was found that prion disease was transmitted through the investigated medical procedures before onset of sCJD. After onset of sCJD, 4.5% of the sCJD patients underwent operations, including neurosurgical for 0.8% and ophthalmic for 1.9%; no special precautions against transmission of prion diseases were taken. Fortunately, we have not identified patients with prion disease attributed to these operations. Our findings indicate that surgical procedures or blood transfusion had little effect on the incidence of sCJD.
authors.affiliation: Kanazawa University Graduate School of Medical Science, Kanazawa, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Hamaguchi
authors.forename: Moeko
authors.initials: M
authors.lastname: Noguchi-Shinohara
authors.forename: Ichiro
authors.initials: I
authors.lastname: Nozaki
authors.forename: Yosikazu
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Sato
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Kitamoto
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Mizusawa
authors.forename: Masahito
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D007562:Creutzfeldt-Jakob Syndrome / Q000453:epidemiology* / Q000635:transmission; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects; D013508:Ophthalmologic Surgical Procedures / Q000009:adverse effects; D017096:Prion Diseases / Q000453:epidemiology* / Q000635:transmission; D018570:Risk Assessment; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D065227:Transfusion Reaction