Saldedines A and B, dibromo proaporphine alkaloids from a Madagascan tunicate.
Two new dibromo proaporphine alkaloids, designated saldedines A (1) and B (2), were isolated from an unidentified tunicate collected at Salary Bay, Madagascar. Saldedines A and B are the first marine proaporphine alkaloids. Their structures were elucidated by extensive spectroscopic means, and the structure of 1 was confirmed by single-crystal X-ray diffraction analysis. Both saldedines A and B were tested for toxicity to brine shrimp and showed moderate activity.
Sorek
Hagit
H
School of Chemistry, Tel-Aviv University, Ramat Aviv, Israel.
Rudi
Amira
A
Goldberg
Israel
I
Aknin
Maurice
M
Kashman
Yoel
Y
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001156:Artemia / Q000187:drug effects*; D018360:Crystallography, X-Ray; D008386:Marine Biology; D015394:Molecular Structure; D014561:Urochordata / Q000737:chemistry*
D000470:Alkaloids; D001060:Aporphines; C540704:saldedine A; C540705:saldedine B