title: Effect of two behavioral tests on corticosterone level in plasma of mice lacking the noradrenaline transporter.
abstract: In the present study, we investigated plasma corticosterone levels of genetically modified mice lacking noradrenaline transporter (NET(-/-)), in response to the forced swim test (FST) and tail suspension test (TST). FST strongly increased the plasma corticosterone level in the first minute after the test (significantly only in NET(+/+) mice), while TST was without any significant effect in both genotypes studied. A single dose of tianeptine (20 mg/kg, ip) shortened immobility time in both tests in NET(-/-) mice, as well as NET(+/+) mice subjected to FST, but not TST. The lack of effect of tianeptine in control animals (NET(+/+)) subjected to TST is also reflected in unchanged levels of plasma corticosterone.
authors.affiliation: Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, PL 31-343 Kraków, Poland. solich@if-pan.krakow.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Solich
authors.forename: Paulina
authors.initials: P
authors.lastname: Pałach
authors.forename: Bogusława
authors.initials: B
authors.lastname: Budziszewska
authors.forename: Marta
authors.initials: M
authors.lastname: Dziedzicka-Wasylewska
mesh_terms: D000818:Animals; D003345:Corticosterone / Q000097:blood*; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D019417:Hindlimb Suspension; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects; D050484:Norepinephrine Plasma Membrane Transport Proteins / Q000502:physiology*; D013550:Swimming; D013841:Thiazepines / Q000494:pharmacology
chemical_list: D050484:Norepinephrine Plasma Membrane Transport Proteins; D013841:Thiazepines; C050504:tianeptine; D010134:Fenclonine; D003345:Corticosterone