Targeting the tumour stroma to increase efficacy of chemo- and radiotherapy.
The impact of a favourable microenvironment on tumour progression is a limiting factor for current tumour therapy protocols, as it contributes to the selection of resistant tumour cells. Apart from immune and inflammatory cells, the extracellular matrix, cancer-associated fibroblasts and vascular endothelial cells are crucial mediators of protective signals. An important research effort exposes potential environmental targets that may define new therapeutic strategies for solid tumours.
Chometon
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Institute for Cell Biology, Department of Molecular Cell Biology, University of Duisburg-Essen, Essen, Germany.
Jendrossek
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D000818:Animals; D003131:Combined Modality Therapy; D019008:Drug Resistance, Neoplasm; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D017154:Stromal Cells / Q000378:metabolism*