title: Segregation distortion at a microsatellite marker in the olive flounder, Paralichtys olivaceus.
abstract: In the course of quantitative trait loci (QTL) analysis of the back cross (BC1) families of olive flounder (Paralichtys olivaceus), we observed significant segregation distortion at a microsatellite marker Poli9-58TUF in two crosses of informative progenies. The family 1 of the random BC1 progenies derived from a cross between a F1 male genotype (A/B) and a F1's female parent genotype (A/C) and the family 2 (A/C x A/C) displayed a strong bias in the locus from the Mendelian inheritance by the elimination of homozygous A/A genotype. The deleterious roles of the AA genotypes are suggested during the metamorphosis and it implies that the parents of these families carried a recessive gene or genes hampering development at an early stage because the offspring of the double heterozygote parents show the reduction in frequency or elimination of one homozygous class, which is an evidence for linkage between the genetic marker and gene(s) with recessive deleterious alleles. This data support a hypothesis that the region contains a recessive lethal gene or genes.
authors.affiliation: Biotechnology Research Institute, National Fisheries Research and Development Institute, 619-902, Republic of Korea. jhkang@nfrdi.re.kr
authors.forename: Jung Ha
authors.initials: JH
authors.lastname: Kang
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Kim
authors.forename: Hyun Chul
authors.initials: HC
authors.lastname: Kim
authors.forename: Jae Koo
authors.initials: JK
authors.lastname: Noh
authors.forename: Jeong Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Kyung Kil
authors.initials: KK
authors.lastname: Kim
mesh_terms: D000483:Alleles; D000818:Animals; D020090:Chromosome Segregation / Q000235:genetics*; D003433:Crosses, Genetic; D005260:Female; D005432:Flounder / Q000235:genetics*; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D007178:Inbreeding; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics*; D040641:Quantitative Trait Loci / Q000235:genetics
chemical_list: D005819:Genetic Markers