Omega-3 fatty acids suppress growth of SW620 human colon cancer xenografts in nude mice.
OBJECTIVE
The purpose of this study was to examine the influence of fish oil on growth of colon cancer in nude mice.


METHODS
Xenografts were initiated in mice receiving a standard diet or diets modified with corn or fish oil. After 3 weeks, mice were sacrificed, tumours were removed and processed for lipid analysis, histopathology and high resolution magic angle spinning magnetic resonance spectroscopy.


RESULTS
Diet modified with fish oil suppressed tumour growth. Xenografts from mice receiving fish oil had higher levels of omega-3 polyunsaturated fatty acids (PUFAs) with concomitant reduced levels of omega-6 PUFAs. Furthermore, these xenografts had significantly lower levels of phosphocholine. Overall the results indicated less aggressive tumour growth in mice receiving a fish oil diet.
Bathen
Tone F
TF
Department of Circulation and Medical Imaging, NTNU, N-7489 Trondheim, Norway. tone.f.bathen@ntnu.no
Holmgren
Kristin
K
Lundemo
Anne Gøril
AG
Hjelstuen
Mari H
MH
Krokan
Hans E
HE
Gribbestad
Ingrid S
IS
Schønberg
Svanhild A
SA
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D048708:Cell Growth Processes / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D019906:Nuclear Magnetic Resonance, Biomolecular; D023041:Xenograft Model Antitumor Assays
D015525:Fatty Acids, Omega-3