title: Catalytic formal Homo-Nazarov cyclization.
abstract: The first catalytic method for the cyclization of vinyl-cyclopropyl ketones (formal homo-Nazarov reaction) is reported. Starting from activated cyclopropanes, heterocyclic, and carbocyclic compounds were obtained under mild conditions using Brønsted acid catalysts. Preliminary investigation of the reaction mechanism indicated a stepwise process.
authors.affiliation: Laboratory of Catalysis and Organic Synthesis Ecole Polytechnique Fédérale de Lausanne EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.
authors.forename: Filippo
authors.initials: F
authors.lastname: De Simone
authors.forename: Julien
authors.initials: J
authors.lastname: Andrès
authors.forename: Riccardo
authors.initials: R
authors.lastname: Torosantucci
authors.forename: Jérôme
authors.initials: J
authors.lastname: Waser
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D003521:Cyclopropanes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D003512:Cyclohexanones; D003521:Cyclopropanes; D007659:Ketones; D014753:Vinyl Compounds