Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: effects on the oxidative stress.
Cadmium (Cd) is a very harmful environmental pollutant that transfers between various levels of the food chain. To study the protective effect of Se and Zn on Cd-induced oxidative stress in livers, male rats received either, tap water, Cd, Cd+Zn, Cd+Se or Cd+Zn+Se in their drinking water, for 35 days. The activities of total superoxide dismutase (SOD), copper, zinc-superoxide dismutase (CuZn SOD), glutathione peroxidase (GPx) and catalase (CAT), malondialdehyde (MDA) level and the ratio of CuZn SOD to GPx activity, were determined in the liver. Exposure to Cd lowered total SOD, CuZn SOD, GPx and CAT activities, while it increased MDA level and the ratio of CuZn SOD to GPx activity, in the organ studied. With Se or Zn administration during exposure to Cd, only partial corrective effects on Cd-induced oxidative stress in the liver have been observed, while Se and Zn together assured a more efficient protection of the organ against the observed oxidative stress.
Jihen
El Heni
el H
Département de Biophysique, Faculté de Médecine de Monastir, Unité de Recherche, Eléments Traces, Radicaux Libres, Antioxydants, Pathologies Humaines et Environnement, Tunisie. jahhounna@yahoo.fr
Imed
Messaoudi
M
Fatima
Hammouda
H
Abdelhamid
Kerkeni
K
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D001835:Body Weight; D019256:Cadmium Chloride; D002374:Catalase / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury; D002712:Chlorides; D004195:Disease Models, Animal; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009929:Organ Size; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D018038:Sodium Selenite / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D013997:Time Factors; D017967:Zinc Compounds
D000975:Antioxidants; D015415:Biomarkers; D002712:Chlorides; D017967:Zinc Compounds; D008315:Malondialdehyde; C016837:zinc chloride; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D018038:Sodium Selenite; D019256:Cadmium Chloride