Kikuchi-Fujimoto disease and systemic lupus erythematosus: the EBV connection?
Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disease of unknown etiology that affects mainly young women. It presents with localized lymphadenopathy, usually cervical, accompanied with fever, night sweats, and leucopenia. KFD has been rarely described in association with autoimmune disorders, mainly systemic lupus erythematosus (SLE). We report the case of a young patient presenting with KFD coinciding with SLE. The association of KFD and SLE is reviewed. Moreover, a possible pathogenetic role of Ebstein-Barr virus linking the two clinical entities is discussed.
Gionanlis
Lazaros
L
Department of Nephrology, General Hospital G. Papanikolaou, Thessaloniki, Greece. lgionanlis@yahoo.com
Katsounaros
Marios
M
Bamihas
Gerasimos
G
Fragidis
Stelios
S
Veneti
Panagiota
P
Sombolos
Kostas
K
D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000821:virology; D055815:Young Adult