title: Management of invasive and advanced thyroid cancer.
abstract: The majority of thyroid cancers are slow growing and have an excellent prognosis after surgical and medical therapy. However, a subset of thyroid cancers do not follow an indolent course, and exhibit aggressive behaviour. Advanced thyroid malignancies can cause distressing and life-threatening symptoms by local invasion, growth of distant metastases. Extensive surgery may have curative or palliative effects, although morbidity should be considered before planning debulking operations. Novel therapies using molecular targets and redifferentiation agents promise to expand our ability to treat patients with advanced thyroid malignancies in the future.
authors.affiliation: Department of Gastroenterological and Surgical Sciences, Endocrine Surgery Unit, University of Padua, Padua, Italy. gennaro.favia@unipd.it
authors.forename: G
authors.initials: G
authors.lastname: Favia
authors.forename: M
authors.initials: M
authors.lastname: Iacobone
authors.forename: S
authors.initials: S
authors.lastname: Zanella
authors.forename: F A
authors.initials: FA
authors.lastname: Ciarleglio
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000473:pathology / Q000556:secondary / Q000628:therapy; D018249:Adenoma, Oxyphilic / Q000601:surgery; D002277:Carcinoma / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D018276:Carcinoma, Medullary / Q000601:surgery; D002291:Carcinoma, Papillary / Q000473:pathology / Q000556:secondary / Q000628:therapy; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D007830:Larynx / Q000473:pathology; D008207:Lymphatic Metastasis; D009334:Neck Muscles / Q000473:pathology; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010166:Palliative Care; D011379:Prognosis; D012009:Recurrent Laryngeal Nerve / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology / Q000628:therapy*; D013965:Thyroidectomy; D014132:Trachea / Q000473:pathology
chemical_list: D007457:Iodine Radioisotopes