Mitochondria and aging: innocent bystanders or guilty parties?
There are many theories of aging and a number of them encompass the role of mitochondria in this process. Mitochondrial DNA mutations and deletions have been shown to accumulate in many tissues in mammals during aging. However, there is little evidence that these mutations could affect the functioning of aging tissues.
Tońska
K
K
Department of Genetics and Biotechnology, University of Warsaw, Pawinskiego 5a, 02-106 Warsaw, Poland.
Sołyga
A
A
Bartnik
E
E
D000375:Aging; D000818:Animals; D017209:Apoptosis; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000235:genetics* / Q000378:metabolism*; D004195:Disease Models, Animal; D017353:Gene Deletion; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000235:genetics* / Q000378:metabolism*; D009154:Mutation; D018384:Oxidative Stress / Q000235:genetics; D012867:Skin / Q000473:pathology; D015595:Skin Aging
D004272:DNA, Mitochondrial