title: Temsirolimus-induced glomerulopathy.
abstract: A 58-year-old man with advanced renal cell carcinoma developed grade 3 proteinuria (8.5 g/24 h) without microscopic hematuria or renal insufficiency five days after temsirolimus infusion. Kidney biopsy revealed ischemic glomeruli and focal segmental glomerulosclerosis lesion. Proteinuria level decreased to 2.80 g per day two weeks after temsirolimus withdrawal. Clinicians should be aware to this complication.
authors.affiliation: Department of Nephrology, Pitié-Salpêtrière Hospital, Paris, France. hassan.izzedine@psl.ap-hop-paris.fr
authors.forename: Hassane
authors.initials: H
authors.lastname: Izzedine
authors.forename: Erfaneh
authors.initials: E
authors.lastname: Boostandoot
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Spano
authors.forename: Armelle
authors.initials: A
authors.lastname: Bardier
authors.forename: David
authors.initials: D
authors.lastname: Khayat
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced*; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000139:chemically induced; D020123:Sirolimus / Q000009:adverse effects / Q000031:analogs & derivatives*
chemical_list: D000970:Antineoplastic Agents; C401859:temsirolimus; D020123:Sirolimus