A TR(I)P to pruritus research: role of TRPV3 in inflammation and itch.
Pruritus in eczema and other inflammatory skin diseases is an unsolved problem. Recent findings strongly indicate that histamine is not the only mediator of pruritus. Subtypes of the transient receptor potential (TRP) ion channel superfamily are expressed by sensory nerves, keratinocytes, and certain leukocytes. Temperature, pH changes, and certain toxins activate TRPs. New evidence indicates that the vanilloid type 3 (TRPV3) channel is crucially involved in pruritic dermatitis, making it a good candidate for future therapy in skin inflammation and pruritus.
Steinhoff
Martin
M
Department of Dermatology, IZKF Münster, Ludwig Boltzmann Institute for Immunobiology of the Skin, University Hospital Münster, Münster, Germany. msteinho@uni-muenster.de
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D000818:Animals; D001831:Body Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007249:Inflammation / Q000276:immunology* / Q000628:therapy*; D015603:Keratinocytes / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D011537:Pruritus / Q000276:immunology* / Q000628:therapy*; D012867:Skin / Q000473:pathology; D050916:TRPV Cation Channels / Q000378:metabolism*; D050051:Transient Receptor Potential Channels / Q000378:metabolism* / Q000502:physiology
D050916:TRPV Cation Channels; C459445:TRPV3 protein, human; D050051:Transient Receptor Potential Channels; C486760:Trpv3 protein, mouse