Stabilities of 67ga- and 111In-labeled transferrin in vitro.
We attempted to develop a stable radiolabeled transferrin (Tf) useful in experimental studies related to Tf receptor. 67Ga and 111In were used as labeling radioisotopes. The results from gel chromatography, dialysis, and electrophoresis showed that 111In-DTPA-Tf was the most stable among the radiolabeled Tfs examined in the present study. 111In-DTPA-Tf was also the most stable radiolabeled transferrin in the blood.
Ohtake
Yosuke
Y
Department of Radiopharmacy, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai, Miyagi 981-8558, Japan. y-ohtake@tohoku-pharm.ac.jp
Maruko
Akiko
A
Kuwahara
Yoshikazu
Y
Fukumoto
Manabu
M
Ohkubo
Yasuhito
Y
D000818:Animals; D003956:Dialysis; D004586:Electrophoresis; D005710:Gallium Radioisotopes / Q000097:blood / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007205:Indium Radioisotopes / Q000097:blood / Q000737:chemistry*; D004369:Pentetic Acid / Q000737:chemistry; D055550:Protein Stability; D051381:Rats; D014168:Transferrin / Q000032:analysis / Q000737:chemistry*
D005710:Gallium Radioisotopes; D007205:Indium Radioisotopes; D014168:Transferrin; D004369:Pentetic Acid