title: Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease.
abstract: We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.
authors.affiliation: Institut National de la Santé Et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR_S) 525, Université Pierre et Marie Curie (UPMC). Paris 06, Paris 75013, France. david.tregouet@upmc.fr
authors.forename: David-Alexandre
authors.initials: DA
authors.lastname: Trégouët
authors.forename: Inke R
authors.initials: IR
authors.lastname: König
authors.forename: Jeanette
authors.initials: J
authors.lastname: Erdmann
authors.forename: Alexandru
authors.initials: A
authors.lastname: Munteanu
authors.forename: Peter S
authors.initials: PS
authors.lastname: Braund
authors.forename: Alistair S
authors.initials: AS
authors.lastname: Hall
authors.forename: Anika
authors.initials: A
authors.lastname: Grosshennig
authors.forename: Patrick
authors.initials: P
authors.lastname: Linsel-Nitschke
authors.forename: Claire
authors.initials: C
authors.lastname: Perret
authors.forename: Maylis
authors.initials: M
authors.lastname: DeSuremain
authors.forename: Thomas
authors.initials: T
authors.lastname: Meitinger
authors.forename: Ben J
authors.initials: BJ
authors.lastname: Wright
authors.forename: Michael
authors.initials: M
authors.lastname: Preuss
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Balmforth
authors.forename: Stephen G
authors.initials: SG
authors.lastname: Ball
authors.forename: Christa
authors.initials: C
authors.lastname: Meisinger
authors.forename: Cécile
authors.initials: C
authors.lastname: Germain
authors.forename: Alun
authors.initials: A
authors.lastname: Evans
authors.forename: Dominique
authors.initials: D
authors.lastname: Arveiler
authors.forename: Gérald
authors.initials: G
authors.lastname: Luc
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Ruidavets
authors.forename: Caroline
authors.initials: C
authors.lastname: Morrison
authors.forename: Pim
authors.initials: P
authors.lastname: van der Harst
authors.forename: Stefan
authors.initials: S
authors.lastname: Schreiber
authors.forename: Katharina
authors.initials: K
authors.lastname: Neureuther
authors.forename: Arne
authors.initials: A
authors.lastname: Schäfer
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.forename: Nour E
authors.initials: NE
authors.lastname: El Mokhtari
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schrezenmeir
authors.forename: Klaus
authors.initials: K
authors.lastname: Stark
authors.forename: Diana
authors.initials: D
authors.lastname: Rubin
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Christian
authors.initials: C
authors.lastname: Hengstenberg
authors.forename: Willem
authors.initials: W
authors.lastname: Ouwehand
authors.forename: Andreas
authors.initials: A
authors.lastname: Ziegler
authors.forename: Laurence
authors.initials: L
authors.lastname: Tiret
authors.forename: John R
authors.initials: JR
authors.lastname: Thompson
authors.forename: Francois
authors.initials: F
authors.lastname: Cambien
authors.forename: Heribert
authors.initials: H
authors.lastname: Schunkert
authors.forename: Nilesh J
authors.initials: NJ
authors.lastname: Samani
mesh_terms: D016633:Apolipoprotein A-II / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006239:Haplotypes; D006801:Humans; D017270:Lipoprotein(a) / Q000235:genetics*; D005810:Multigene Family; D027701:Organic Cation Transport Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D012307:Risk Factors; D000099254:Organic Cation Transporter 3
chemical_list: D016633:Apolipoprotein A-II; D017270:Lipoprotein(a); D027701:Organic Cation Transport Proteins; D000099254:Organic Cation Transporter 3; C115794:APOA2 protein, human