Antiglucocorticoids, neurogenesis and depression.
Recent evidence suggests that antiglucocorticoids, like conventional antidepressants, may recover depressive symptoms by boosting hippocampal neurogenesis. Here, we explore several possible antiglucocorticoid-based antidepressive therapeutic strategies. Firstly, we review specific glucocorticoid receptor/antagonist interactions. Secondly, we discuss a potential new therapeutic target, doublecortin-like kinase, which regulates glucocorticoid signaling in neuronal progenitor cells.
Fitzsimons
Carlos P
CP
LACDR/Medical Pharmacology Department, Leiden University, Gorlaeus Laboratory, Einsteinweg 55, 2333CC Leiden, The Netherlands.
van Hooijdonk
Lenneke W A
LW
Morrow
John A
JA
Peeters
Bernard W M M
BW
Hamilton
Niall
N
Craighead
Mark
M
Vreugdenhil
Erno
E
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000378:metabolism*; D005938:Glucocorticoids / Q000037:antagonists & inhibitors*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008958:Models, Molecular; D009417:Nerve Tissue / Q000254:growth & development*; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism / Q000523:psychology
D000928:Antidepressive Agents; D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid