Antiviral defense: RIG-Ing the immune system to STING.
A critical component of the innate immune response is the presence of germ line-encoded receptors capable of recognizing a wide variety of pathogen-associated molecules. One group of these receptors, the cytoplasmic RIG-I-like helicases (RLH), is involved in the induction of Type I interferon in response to viral infection. Here we discuss results of recent investigations into the initiation and transmission of signals through the RIG-I pathway.
Bowzard
J Bradford
JB
Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Ranjan
Priya
P
Sambhara
Suryaprakash
S
Fujita
Takashi
T
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007107:Immune System; D007370:Interferon Type I / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D011485:Protein Binding; D011487:Protein Conformation; D012367:RNA, Viral / Q000378:metabolism; D011971:Receptors, Immunologic; D015398:Signal Transduction; D014158:Transcription, Genetic; D000099197:STING Protein
D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D007370:Interferon Type I; D008565:Membrane Proteins; D012367:RNA, Viral; D011971:Receptors, Immunologic; C532857:STING1 protein, human; D000099197:STING Protein; C452820:RIGI protein, human