Helical-screw directions of diastereoisomeric cyclic alpha-amino acid oligomers.
Two series of homooligomers composed of diastereoisomeric cyclic alpha-amino acids having two chiral centers at the alpha-carbon and the side chain were synthesized, and their preferred secondary structures were studied in solution and in the crystal state. The oligomers are a new class of helical-foldamers possessing two kinds of chiral centers on the helical backbone and at the lateral surface of the helix.
Nagano
Masanobu
M
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Tanaka
Masakazu
M
Doi
Mitsunobu
M
Demizu
Yosuke
Y
Kurihara
Masaaki
M
Suemune
Hiroshi
H
D000596:Amino Acids / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism
D000596:Amino Acids; D009842:Oligopeptides