title: Cardiovascular conditions in hemodialysis patients may be worsened by extensive interdialytic weight gain.
abstract: The risk of death is increased for hemodialysis (HD) patients compared with age-matched healthy subjects, the main reason for this being cardiovascular conditions. This prospective study investigated whether the burden of interdialytic weight gain (IDWG) was of importance for cardiovascular end points and survival. A total of 97 HD patients were studied. The end points included death (reasons given), acute myocardial infarction, or coronary vascular intervention. The extent of ultrafiltration was measured at predefined follow-up points. The IDWG was calculated as ultrafiltration/body weight given in weight%. The burden of IDWG was analyzed. End points occurred in 77 (79%) of the patients during the 5-year study period. The extent of IDWG was higher in those with end points due to cardiovascular reasons (3.77 weight% vs. 3.19 P<0.001), cardiac reasons (P<0.001), congestive heart failure (P<0.01), aortic aneurysm, and intracerebral bleeding (P<0.024). To reduce the risk for cardiovascular events, it is important to avoid too extensive IDWG in HD patients.
authors.affiliation: Department of Internal Medicine, University Hospital, Umeå, Sweden. benny.holmberg@vll.se
authors.forename: Benny
authors.initials: B
authors.lastname: Holmberg
authors.forename: Bernd G
authors.initials: BG
authors.lastname: Stegmayr
mesh_terms: D000328:Adult; D000368:Aged; D000069059:Atorvastatin; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D006538:Heptanoic Acids / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011758:Pyrroles / Q000494:pharmacology; D012044:Regression Analysis; D006435:Renal Dialysis / Q000009:adverse effects*; D015430:Weight Gain
chemical_list: D006538:Heptanoic Acids; D011758:Pyrroles; D000069059:Atorvastatin