title: [Analysis of adverse drug reaction of gatifloxacin in Hunan province from Aug. 2003 to Jul. 2007].
abstract: OBJECTIVE
  To summarize the occurrences of adverse drug reactions (ADR) of gatifloxacin, and to guide the rational usage of antibacterial agents in clinical practice in the future.
  
  
  METHODS
  A total of 1 077 ADR patient who received gatifloxacin were retrospectively studied in Hunan province from August 2003 to July 2007.
  
  
  RESULTS
  Gatifloxacin could cause multi-system and multi-organ ADRs with wide variety of clinical manifestations. Of the 1 077 ADR patients, ADR incidence rate was slightly lower in males than that in females, the age of 821 (76.23%) ADR patients were 20 approximately 59 years; 905 (84.03%) were administered intravenously; and 682 (33.07%) had severe lesions of the digestive system, followed by lesions of the skin and the appendants (490 cases, 23.76%) and the nervous system (298 cases, 14.45%).
  
  
  CONCLUSIONS
  ADR caused by gatifloxacin should be monitored and reported so as to reduce or avoid ADR.
authors.affiliation: Department of Pharmacy, Central South University, Changsha 410008,China. yjsd2003@163.com
authors.forename: Sheng
authors.initials: S
authors.lastname: Deng
authors.forename: Yanchun
authors.initials: Y
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Yin
authors.forename: Liping
authors.initials: L
authors.lastname: Long
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D016907:Adverse Drug Reaction Reporting Systems; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002681:China; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D024841:Fluoroquinolones / Q000009:adverse effects*; D000077734:Gatifloxacin; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D000077734:Gatifloxacin