title: Vaccine-induced immunity circumvented by typical Mycobacterium tuberculosis Beijing strains.
abstract: The frequency of typical and atypical Beijing strains of Mycobacterium tuberculosis was determined in the Netherlands; Vietnam; and Hong Kong Special Administrative Region, People's Republic of China. The strains' associations with drug resistance, M. bovis BCG vaccination, and patient characteristics were assessed. BCG vaccination may have positively selected the prevalent typical Beijing strains.
authors.affiliation: National Institute for Public Health and the Environment, Bilthoven, the Netherlands. kristin.kremer@rivm.nl
authors.forename: Kristin
authors.initials: K
authors.lastname: Kremer
authors.forename: Marieke J
authors.initials: MJ
authors.lastname: van-der-Werf
authors.forename: Betty K Y
authors.initials: BK
authors.lastname: Au
authors.forename: Dang D
authors.initials: DD
authors.lastname: Anh
authors.forename: Kai M
authors.initials: KM
authors.lastname: Kam
authors.forename: H Rogier
authors.initials: HR
authors.lastname: van-Doorn
authors.forename: Martien W
authors.initials: MW
authors.lastname: Borgdorff
authors.forename: Dick
authors.initials: D
authors.lastname: van-Soolingen
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology*; D000940:Antigenic Variation; D000995:Antitubercular Agents / Q000494:pharmacology; D001500:BCG Vaccine / Q000008:administration & dosage* / Q000276:immunology; D002681:China; D004251:DNA Transposable Elements; D024881:Drug Resistance, Bacterial; D005260:Female; D005838:Genotype; D006723:Hong Kong; D006801:Humans; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D009426:Netherlands; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D014376:Tuberculosis / Q000276:immunology* / Q000382:microbiology / Q000517:prevention & control; D014611:Vaccination; D014744:Vietnam
chemical_list: D000907:Antibodies, Bacterial; D000995:Antitubercular Agents; D001500:BCG Vaccine; D004251:DNA Transposable Elements; D007538:Isoniazid