A novel versipelostatin analogue, versipelostatin F isolated from Streptomyces versipellis 4083-SVS6.
A novel versipelostatin (1) analogue, versipelostatin F (2) was isolated from Streptomyces versipellis 4083-SVS6. The structure of 2 was determined by the analyses of the spectroscopic data. Compound 2 inhibited the expression of GRP78 induced by 2-deoxyglucose with an IC(50) value of 0.3 muM, which is 10-times more potent compared with that of 1.
Ueda
Jun-Ya
JY
Biomedicinal Information Research Center (BIRC), National Institute of Advanced Industrial Science and Technology (AIST), 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Chijiwa
Shuhei
S
Takagi
Motoki
M
Shin-Ya
Kazuo
K
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D000091342:Endoplasmic Reticulum Chaperone BiP; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D006360:Heat-Shock Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification*; D018832:Molecular Chaperones / Q000037:antagonists & inhibitors; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis; D013302:Streptomyces / Q000737:chemistry*
D000970:Antineoplastic Agents; D000091342:Endoplasmic Reticulum Chaperone BiP; D004791:Enzyme Inhibitors; C000717247:HSPA5 protein, human; D006360:Heat-Shock Proteins; D018942:Macrolides; D018832:Molecular Chaperones; D009844:Oligosaccharides; C490154:versipelostatin