Acquired pericentric inversion of chromosome 9 in acute myeloid leukemia.
Pericentric inversion of chromosome 9 involving the qh region is relatively common as a constitutional genetic aberration without any apparent phenotypic consequences. However, it has not been established as an acquired abnormality in cancer. Among the three patients reported so far in the literature with acquired inv(9), only one had acute myeloid leukemia (AML). Here we describe an unique case where both chromosomes 9 presented with an acquired pericentric inversion with breakpoints at 9p13 and 9q12 respectively, in a AML patient with aberrant CD7 and CD9 positivity. Additionally, one der(9) also showed short arm deletion at 9p21 to the centromeric region and including the p16 gene. The constitutional karyotype was normal. This is probably the first report describing an acquired inv(9) involving both chromosomes 9 in AML. The possible significance of this inversion is discussed.
Udayakumar
A M
AM
Cytogenetics Laboratory, Department of Genetics, College of Medicine and Health Sciences, Sultan Qaboos University, P.O.Box 35, P.C.123, Muscat, Sultanate of Oman. amuk19@hotmail.com
Pathare
A V
AV
Dennison
D
D
Raeburn
J A
JA
D015703:Antigens, CD / Q000096:biosynthesis; D019011:Antigens, CD7 / Q000096:biosynthesis; D002871:Chromosome Banding; D002872:Chromosome Deletion; D007446:Chromosome Inversion; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D060245:Tetraspanin 29
D015703:Antigens, CD; D019011:Antigens, CD7; C554869:CD9 protein, human; D008562:Membrane Glycoproteins; D060245:Tetraspanin 29