A Mathematical Framework for Incorporating Anatomical Knowledge in DT-MRI Analysis.
We propose a Bayesian approach to incorporate anatomical information in the clustering of fiber trajectories. An expectation-maximization (EM) algorithm is used to cluster the trajectories, in which an atlas serves as the prior on the labels. The atlas guides the clustering algorithm and makes the resulting bundles anatomically meaningful. In addition, it provides the seed points for the tractography and initial settings of the EM algorithm. The proposed approach provides a robust and automated tool for tract-oriented analysis both in a single subject and over a population.
Maddah
Mahnaz
M
Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Zöllei
Lilla
L
Grimson
W Eric L
WE
Westin
Carl-Fredrik
CF
Wells
William M
WM