title: Expression of PTEN and SHP1, investigated from tissue microarrays in pediatric acute lymphoblastic, leukemia.
abstract: PTEN and SHP1 are tumor suppressor genes involved in the regulation of cell cycle control and apoptosis. The authors investigated the protein expression of PTEN and SHP1, by immunohistochemistry in tissue microarrays from bone marrow samples in children, diagnosed with acute lymphoblastic leukaemia and nonmalignant controls. PTEN was overexpressed in diagnostic ALL samples, while SHP1 showed a low expression. Both proteins showed a significant difference in expression compared to nonmalignant controls. The roles of PTEN and SHP1 are not well investigated in pediatric leukemia and could in the future play a role as prognostic factors.
authors.affiliation: Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Fredrika
authors.initials: F
authors.lastname: Gauffin
authors.forename: Eva
authors.initials: E
authors.lastname: Diffner
authors.forename: Bertil
authors.initials: B
authors.lastname: Gustafsson
authors.forename: Ann
authors.initials: A
authors.lastname: Nordgren
authors.forename: Anette Gjörloff
authors.initials: AG
authors.lastname: Wingren
authors.forename: Birgitta
authors.initials: B
authors.lastname: Sander
authors.forename: Jenny Liao
authors.initials: JL
authors.lastname: Persson
authors.forename: Britt
authors.initials: B
authors.lastname: Gustafsson
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor; D001853:Bone Marrow / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D051059:PTEN Phosphohydrolase / Q000032:analysis*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology*; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6 / Q000032:analysis*; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; C509249:PTPN6 protein, human; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human