title: Modular stereocontrolled assembly of R2Zn, cyclic enones and N-tert-butanesulfinyl imines.
abstract: The assembly of a wide range of dialkylzincs, cyclic enones, and chiral N-tert-butylsulfinyl imines in the presence of the appropriate phosphoramidite ligands allowed the formation of beta-amino ketones with three consecutive stereogenic centers in a stereocontrolled manner. The Baeyer-Villiger oxidation of the resulting amino ketones led to the corresponding aminolactones with excellent regio- and stereoselectivities.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica, Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain. josecarlos.gonzalez@ua.es
authors.forename: José C
authors.initials: JC
authors.lastname: González-Gómez
authors.forename: Francisco
authors.initials: F
authors.lastname: Foubelo
authors.forename: Miguel
authors.initials: M
authors.lastname: Yus