Direct palladium-catalyzed alkenylation, benzylation and alkylation of ethyl oxazole-4-carboxylate with alkenyl-, benzyl- and alkyl halides.
The ethyl oxazole-4-carboxylate was directly and regioselectively alkenylated, benzylated and alkylated with alkenyl-, benzyl-, allyl- and alkyl halides in the presence of catalytic amounts of palladium acetate with caesium carbonate using Buchwald's JohnPhos ligand.
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Institut de Chimie Organique Fine associé au CNRS (UMR 6014), INSA et Université de Rouen, BP08 76131, Mont Saint Aignan, France.
Hoarau
Christophe
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Marsais
Francis
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