title: Changeability of oral cavity environment.
abstract: OBJECTIVE
  In dentistry, the results of in vivo studies on drugs, dental fillings or prostheses are routinely evaluated based on selected oral cavity environment parameters at specific time points. Such evaluation may be confounded by ongoing changes in the oral cavity environment induced by diet, drug use, stress and other factors. The study aimed to confirm oral cavity environment changeability.
  
  
  METHODS
  24 healthy individuals aged 20-30 had their oral cavity environment prepared by having professional hygiene procedures performed and caries lesions filled. Baseline examination and the examination two years afterwards, evaluated clinical and laboratory parameters of oral cavity environment. Caries incidence was determined based on DMFT and DMFS values, oral cavity hygiene on Plaque Index (acc. Silness & Loe) and Hygiene Index (acc. O'Leary), and the gingival status on Gingival Index (acc. Loe & Silness) and Gingival Bleeding Index (acc. Ainamo & Bay). Saliva osmolarity, pH and concentrations of Ca(2+), Pi, Na(+), Cl(-), total protein, albumins, F(-) and Sr(2+) were determined.
  
  
  RESULTS
  The results confirmed ongoing changeability of the oral cavity environment. After 2 years of the study reduction in oral cavity hygiene parameters PLI and HI (P<0.1), and gingival indices as well as lower saliva concentration of Ca(2+) (P<.001), Pi (P<.06), K(+) (P<.04), Sr(2+) (P<.03), Na(+) (P<.1), against the baseline values, were observed. Total protein and albumin saliva concentrations were also significantly lower.
  
  
  CONCLUSIONS
  Physiological oral cavity environment is subject to constant, individually different, changes which should be considered when analysing studies that employ oral cavity environment parameters.
authors.affiliation: Department of Conservative, Dentistry & Periodontology.
authors.forename: Anna
authors.initials: A
authors.lastname: Surdacka
authors.forename: Krystyna
authors.initials: K
authors.lastname: Strzyka A
authors.forename: Anna
authors.initials: A
authors.lastname: Rydzewska