[Evaluation of cerebrospinal fluid serotonin (5-HT) concentration in patients with post-Lyme disease syndrome--preliminary study].
The aim of the study was evaluation of usefulness of cerebrospinal fluid (CSF) serotonin level examination in diagnostics of post-Lyme disease syndrome. The study was performed in 16 subjects. In all individuals CSF serotonin concentration was estimated on the 1st day of hospitalization. In patients with depressive and cognitive impairments, proved in neuropsychological tests, - group I--mean CSF serotonin concentration was 1,26 ng/ml, whereas in subjects without abnormalities in tests--group II--respectively--3,87 ng/ml. The difference of mean CSF serotonin levels was statistically significant (p<0,01). The obtained results indicate usefulness of this CSF parameter, besides neuropsychological tests, in objective evaluation of clinical state in patients with post-Lyme disease syndrome.
Kepa
Lucjan
L
Oddział Chorób Zakaźnych Slaskiego Uniwersytetu Medycznego w Bytomiu.
Oczko-Grzesik
Barbara
B
Badura-Glombik
Teresa
T
D000328:Adult; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000209:etiology; D003863:Depression / Q000134:cerebrospinal fluid* / Q000209:etiology; D005260:Female; D006801:Humans; D020852:Lyme Neuroborreliosis / Q000134:cerebrospinal fluid* / Q000150:complications; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011044:Poland; D012307:Risk Factors; D012701:Serotonin / Q000134:cerebrospinal fluid*; D012720:Severity of Illness Index; D013577:Syndrome
D012701:Serotonin