Clinical significance of interleukin-10 gene polymorphisms and plasma levels in Hodgkin lymphoma.
We studied plasma levels of IL-10 and five single nucleotide polymorphisms in the interleukin-10 (IL-10) gene promoter in patients with Hodgkin lymphoma (HL) to address potential genotype-phenotype correlations. Patients with elevated IL-10 levels were more likely to have advanced stage disease and inferior event-free survival. Homozygous carriers of the variant alleles at position -592 (AA) and -1082 (GG) of the IL-10 promoter had higher IL-10 plasma levels, independent of male gender and advanced stage of disease which also determined increased IL-10 production. This analysis indicates that the genetic background can modulate plasma levels of IL-10, and ultimately prognosis in HL.
Hohaus
Stefan
S
Istituto di Ematologia, Universita' Cattolica S. Cuore, Rome, Italy. stefan.hohaus@rm.unicatt.it
Giachelia
Manuela
M
Massini
Giuseppina
G
Vannata
Barbara
B
Criscuolo
Marianna
M
Martini
Maurizio
M
D'Alo'
Francesco
F
Voso
Maria Teresa
MT
Larocca
Luigi Maria
LM
Leone
Giuseppe
G
D000328:Adult; D004273:DNA, Neoplasm / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis; D005260:Female; D005784:Gene Amplification; D014644:Genetic Variation; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000150:complications / Q000235:genetics* / Q000473:pathology; D006720:Homozygote; D006801:Humans; D016753:Interleukin-10 / Q000097:blood / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D011401:Promoter Regions, Genetic
D004273:DNA, Neoplasm; D016753:Interleukin-10