title: [Prediction of prognosis of patients with pancreatic adenocarcinoma with curative intent resection by means of histologic grade and pathologic N stage].
abstract: OBJECTIVE
  Pancreatic cancer has the poorest prognosis of any common gastrointestinal malignancy, with a 5-year overall survival of less than 5%. A better knowledge of prognostic factors related to this neoplasia might help improve the survival of these patients. We evaluated the prognostic significance of different factors in both overall survival and tumor recurrence in patients with pancreatic adenocarcinoma who had undergone pancreatic resection with curative intent.
  
  
  METHODS
  All patients with pancreatic adenocarcinoma submitted to surgical resection in our unit from January 1995 to February 2005 were evaluated. Twenty-three pre-surgical, therapeutic, and histopathologic variables were analyzed. Univariate (Kaplan-Meier, log-rank test) and multivariate (Cox regression) analyses were performed to select independent prognostic factors.
  
  
  RESULTS
  Ninety-four patients were evaluated. The median age of patients was 63 years and 53% were woman. The probability of overall survival was 63% at 1 year, 18% at 3 years, and 8% at 5 years, with a median survival of 18 months. Univariate analysis identified performance of adjuvant therapy, histologic grade, percentage of involved-resected lymph nodes, pathologic N stage, and pathologic TNM stage as variables associated with overall survival. On the other hand, the probability of tumor recurrence was 52% at 1 year, 83% at 3 years, and 91% at 5 years, with a median time to tumor recurrence of 12 months. Predictive variables of tumor recurrence in the univariate analysis were preoperative N stage, preoperative TNM stage, postoperative CA 19.9 serum concentration, histological grade, percentage of involved-resected lymph nodes, pathologic N stage and pathologic TNM stage. Multivariate analysis identified histological grade and pathologic N stage as independent predictive factors of both overall survival (histologic grade: HR=2.341 [CI 95%, 1.342-4.098; p=0.003]; pathologic N stage: HR=2.242 [1.213-4.149; p=0.01]) and tumor recurrence (histological grade: HR=1.742 [CI 95%, 1.121-3.086; p=0.05]; pathologic N stage: HR=2.096 [1.089-4.032; p=0.027]).
  
  
  CONCLUSIONS
  The histological grade and pathologic N stage predict the prognosis of patients with pancreatic adenocarcinoma after surgical resection.
authors.affiliation: Servicio de Gastroenterología, Institut de Malalties Digestives i Metabòliques, Hospital Clínic. Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), CIBERehd. Universidad de Barcelona, Barcelona, España.
authors.forename: Antonio
authors.initials: A
authors.lastname: Soriano-Izquierdo
authors.forename: Ana C
authors.initials: AC
authors.lastname: Adet
authors.forename: Rosa
authors.initials: R
authors.lastname: Gallego
authors.forename: Rosa
authors.initials: R
authors.lastname: Miquel
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
authors.forename: María
authors.initials: M
authors.lastname: Pellisé
authors.forename: Cristina
authors.initials: C
authors.lastname: Nadal
authors.forename: Miguel A
authors.initials: MA
authors.lastname: López-Boado
authors.forename: Josep M
authors.initials: JM
authors.lastname: Piqué
authors.forename: Pere
authors.initials: P
authors.lastname: Gascón
authors.forename: Carles
authors.initials: C
authors.lastname: Conill
authors.forename: Antoni
authors.initials: A
authors.lastname: Bombí
authors.forename: Laureano
authors.initials: L
authors.lastname: Fernández-Cruz
authors.forename: Joan
authors.initials: J
authors.lastname: Maurel
authors.forename: Salvador
authors.initials: S
authors.lastname: Navarro
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D011379:Prognosis; D015996:Survival Rate