Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates.
A chemically diverse library of TAGE-triazole conjugates was synthesized utilizing click chemistry on the TAGE scaffold. This library of small molecules was screened for anti-biofilm activity and found to possess the ability of inhibiting biofilm formation against Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa. One such compound in this library demonstrated the most potent inhibitory effect against Staphylococcus aureus biofilm formation that has been displayed by any 2-aminoimidazole derivative.
Huigens
Robert W
RW
North Carolina State University Chemistry Department, 2620 Yarborough Drive, Raleigh, North Carolina 27695-8204, United States of America.
Rogers
Steven A
SA
Steinhauer
Andrew T
AT
Melander
Christian
C
D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D018441:Biofilms / Q000187:drug effects*; D007093:Imidazoles / Q000737:chemistry; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D054852:Small Molecule Libraries / Q000138:chemical synthesis; D013211:Staphylococcus aureus / Q000187:drug effects; D014230:Triazoles / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D007093:Imidazoles; D054852:Small Molecule Libraries; C533873:TAGE compound; D014230:Triazoles; C014973:2-aminoimidazole