title: Delayed microbial cure of lymphogranuloma venereum proctitis with doxycycline treatment.
abstract: Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7 days. These findings support the Centers for Disease Control and Prevention's treatment recommendation of a 21-day doxycycline regimen for LGV proctitis and a 7-day regimen for non-LGV chlamydia proctitis. Delayed microbial cure of LGV proctitis should be considered in improved treatment regimens.
authors.affiliation: Sexually Transmitted Infection Outpatient Clinic, Health Service Amsterdam, Amsterdam, The Netherlands. h.j.devries@amc.nl
authors.forename: Henry J C
authors.initials: HJ
authors.lastname: de Vries
authors.forename: Vitaly
authors.initials: V
authors.lastname: Smelov
authors.forename: Judith G
authors.initials: JG
authors.lastname: Middelburg
authors.forename: Jolein
authors.initials: J
authors.lastname: Pleijster
authors.forename: Arjen G
authors.initials: AG
authors.lastname: Speksnijder
authors.forename: Servass A
authors.initials: SA
authors.lastname: Morré
mesh_terms: D001003:Anal Canal / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000302:isolation & purification; D004269:DNA, Bacterial / Q000302:isolation & purification; D004318:Doxycycline / Q000627:therapeutic use*; D006801:Humans; D008219:Lymphogranuloma Venereum / Q000188:drug therapy*; D008297:Male; D011349:Proctitis / Q000188:drug therapy*; D012329:RNA, Bacterial / Q000302:isolation & purification; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D012329:RNA, Bacterial; D004318:Doxycycline