Acute myocardial infarction associated with disulfiram-alcohol interaction in a young man with normal coronary arteries.
Acute myocardial infarction due to acetaldehyde syndrome has been rarely reported. A 22-year-old, chronic alcoholic man was admitted to our hospital with typical angina pectoris that developed after oral intake of disulfiram and alcohol together. The electrocardiogram showed hyperacute inferior myocardial infarction and he was successfully treated by thrombolytic therapy. Coronary angiogram revealed normal coronary arteries; thus, the event was probably secondary to coronary artery thrombosis and/or coronary vasospasm. Disulfiram is not a safe drug in patients unable to adhere to the strict restriction of alcohol intake, requiring a close supervision of individuals on disulfiram therapy.
Tayyareci
Yelda
Y
Department of Cardiology, Merzifon State Hospital, Amasya, Turkey. yeldatayyareci@hotmail.com
Acarel
Esra
E
D000427:Alcohol Deterrents / Q000008:administration & dosage / Q000009:adverse effects*; D000437:Alcoholism / Q000150:complications* / Q000188:drug therapy; D017023:Coronary Angiography; D004221:Disulfiram / Q000008:administration & dosage / Q000009:adverse effects*; D000431:Ethanol / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced*; D010349:Patient Compliance; D012907:Smoking / Q000009:adverse effects; D055815:Young Adult
D000427:Alcohol Deterrents; D000431:Ethanol; D004221:Disulfiram