title: Associations between HLA-C alleles and papillary thyroid carcinoma.
abstract: OBJECTIVE
  Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of this study was to determine the association between HLA-C allele frequencies and papillary thyroid carcinoma in an Iranian population.
  
  
  METHODS
  HLA-Cw allele frequencies were determined in patients with papillary thyroid carcinoma (N = 54) and non-related healthy controls (N = 91) using PCR-SSP.
  
  
  RESULTS
  We found that HLACw4 and HLACw15 allele frequencies were significantly higher in our patients compared to the controls [P = 10-4, OR; 12.5, 95% CI 2.6-116.9) and [P = 10-4, OR; 24.7, 95% CI (3.6-1058) respectively].
  
  
  CONCLUSIONS
  Our results revealed certain HLA-C alleles are predisposing factors in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for association between HLA-C alleles and differentiated carcinomas in other populations.
authors.affiliation: Endocrinology and Metabolism Research Centre, University of Tehran/Medical Sciences, Tehran, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Haghpanah
authors.forename: Keinoosh
authors.initials: K
authors.lastname: Khalooghi
authors.forename: Khadijeh
authors.initials: K
authors.lastname: Adabi
authors.forename: Parvin
authors.initials: P
authors.lastname: Amiri
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Tavangar
authors.forename: Ali
authors.initials: A
authors.lastname: Amirzargar
authors.forename: Hamidollah
authors.initials: H
authors.lastname: Ghaffari
authors.forename: Nasrin
authors.initials: N
authors.lastname: Yazdani
authors.forename: Behrooz
authors.initials: B
authors.lastname: Nikbin
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics*
chemical_list: D015236:HLA-C Antigens