title: Systemic lupus erythematosus presenting as acute iceric hepatitis: a case report.
abstract: Liver involvement in systemic lupus erythematosus (SLE) is infrequent. The coexistence of SLE and autoimmune hepatitis is rare (1.3-1.7%). We report a case of a 27 year old female with no history of systemic illnesses or alcohol abuse that presented with acute hepatitis with jaundice, abdominal pain, and increased liver function tests. Viral markers were negative. ANA was strongly positive. Patient was suspected to have SLE but no definite diagnosis made. She remained asymptomatic for 9 years but then she had recurrence of hepatitis. She also presented with malar rash, arthritis, and proteinuria. At that time a liver biopsy showed autoimmune hepatitis. Other tests which confirmed SLE included a positive antidsDNA, positive antismith antibody and decreased complement levels. She was started on prednisone 40 mg with mild improvement of symptoms and transaminase values, but when azathioprine 100 mg was added a marked improvement in liver function tests was observed. After a year in azathioprine she remained with SLE in remission. To our knowledge this is the third reported case and the first in the Western Hemisphere of jaundice as the initial presentation of SLE.
authors.affiliation: Rheumatology Section, Internal Medicine Department, UPR School of Medicine. varodriguez@rcm.upr.edu
authors.forename: Vanessa E
authors.initials: VE
authors.lastname: Rodriguez
authors.forename: Pablo
authors.initials: P
authors.lastname: Costas
mesh_terms: D000328:Adult; D005260:Female; D006505:Hepatitis / Q000209:etiology*; D006801:Humans; D007565:Jaundice / Q000209:etiology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis*