title: Effect of body mass index on the outcome of infections: a systematic review.
abstract: It has not been adequately evaluated whether the outcome of infections differs by body-weight category. We performed a systematic review of relevant studies. Eleven studies (one retrospective and 10 prospective cohort studies) were included in this review, involving a total of 3159 hospitalized patients or nursing home residents. Most studies (6/11) referred to lower respiratory tract infections. Seven studies showed an association of patient outcome (mortality in 6/7 studies) with body-weight category. This was shown in multivariate analysis in 4/5 studies that reported relevant data. Obese or morbidly obese patients with infections had worse outcome compared with the rest of the patients or with normal-weight patients, in 4/7 studies that reported relevant data; findings were not significant in the remaining three studies. Patients in the lowest body mass index (BMI) group had worse outcome compared with all other groups combined, in 3/5 studies that reported relevant data; findings were not significant in the remaining two studies. Low BMI was associated with worse outcome in patients with lower respiratory tract infections in 3/4 relevant studies. Although not consistently reported, an association of both ends of the BMI distribution with worse outcome of infections is plausible and merits further investigation.
authors.affiliation: Alfa Institute of Biomedical Sciences, Athens, Greece. m.falagas@aibs.gr
authors.forename: M E
authors.initials: ME
authors.lastname: Falagas
authors.forename: A P
authors.initials: AP
authors.lastname: Athanasoulia
authors.forename: G
authors.initials: G
authors.lastname: Peppas
authors.forename: D E
authors.initials: DE
authors.lastname: Karageorgopoulos
mesh_terms: D015992:Body Mass Index; D001835:Body Weight; D006801:Humans; D007239:Infections / Q000401:mortality*