Is oxidative damage in operation in patients with hereditary spastic paraparesis?
Oxidative stress resulting from increased free radical production and/or defects in antioxidant defences may be the cause of various neurodegenerative disorders. In this study, the roles of oxygen free radicals, nitric oxide, superoxide dismutase, vitamin E and vitamin C were investigated in pure and complicated hereditary spastic paraparesis (HSP) patients. The results showed that plasma SOD, vitamin E and nitric oxide levels were significantly low in HSP patients. These findings indicate the influence of oxidative damage in the degenerative process of HSP.
Gücüyener
Kivilcim
K
Department of Pediatric Neurology, Gazi University, Beşevler, Ankara, Turkey.
Pinarli
F Güçlü
FG
Erbaş
Deniz
D
Hasanoğlu
Alev
A
Serdaroğlu
Ayşe
A
Topaloğlu
Haluk
H
D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D016166:Free Radical Scavengers / Q000097:blood; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D020336:Paraparesis, Spastic / Q000097:blood / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D012720:Severity of Illness Index; D015419:Spastic Paraplegia, Hereditary / Q000097:blood / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
D000975:Antioxidants; D016166:Free Radical Scavengers; D005609:Free Radicals; D014810:Vitamin E; D009569:Nitric Oxide; D013482:Superoxide Dismutase; D001205:Ascorbic Acid