title: Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600.
abstract: Erythronolides H and I, novel congeners of the clinically important antibacterial drug erythromycin A, have been isolated from the new halophilic actinomycete Actinopolyspora sp. YIM90600. In addition to producing the new erythromycin congeners, A. sp. YIM90600 produces erythromycin C in a high titer. The presence of the C-14 hydroxyl moiety and the C-6/C-18-epoxide in erythronolide H and the spiroketal moiety of erythronolide I sheds new insights into structural diversity of erythromycin analog libraries potentially accessible by combinatorial biosynthesis.
authors.affiliation: Division of Pharmaceutical Sciences, Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Li-Xing
authors.initials: LX
authors.lastname: Zhao
authors.forename: Shu-Kun
authors.initials: SK
authors.lastname: Tang
authors.forename: Cheng-Lin
authors.initials: CL
authors.lastname: Jiang
authors.forename: Yanwen
authors.initials: Y
authors.lastname: Duan
authors.forename: Ben
authors.initials: B
authors.lastname: Shen
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; C539663:erythronolide H; C539664:erythronolide I; D004917:Erythromycin