title: Pathology type does not predict language lateralization in children with medically intractable epilepsy.
abstract: OBJECTIVE
  We examined potential differences in the effects of pathology type on language lateralization in pediatric epilepsy.
  
  
  METHODS
  We examined findings from intracarotid sodium amobarbital procedure (IAP/Wada) in a large consecutive sample of children with refractory epilepsy. Subjects were assigned to one of three pathology groups: developmental (n = 28), acquired (n = 26), and tumor (n = 20); groups were compared for language lateralization.
  
  
  RESULTS
  Rates of atypical language lateralization did not differ across groups. Greater than half of the subjects with left hemisphere insults and seizure onset before 6 years of age had atypical language lateralization, independent of pathology type.
  
  
  CONCLUSIONS
  Atypical language lateralization may occur in the context of developmental, acquired, and/or tumor pathology.
authors.affiliation: Department of Psychology, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Darren S
authors.initials: DS
authors.lastname: Kadis
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Kerr
authors.forename: James T
authors.initials: JT
authors.lastname: Rutka
authors.forename: O Carter
authors.initials: OC
authors.lastname: Snead
authors.forename: Shelly K
authors.initials: SK
authors.lastname: Weiss
authors.forename: Mary Lou
authors.initials: ML
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D016009:Chi-Square Distribution; D002648:Child; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000150:complications* / Q000473:pathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007806:Language Disorders / Q000145:classification / Q000209:etiology* / Q000473:pathology*; D007807:Language Tests; D008297:Male