title: Genitourinary fistula experience in Sierra Leone: review of 505 cases.
abstract: OBJECTIVE
  We reviewed cases of genitourinary fistula resulting from birth trauma in Sierra Leone to determine factors predictive of successful operative repair.
  
  
  METHODS
  A total of 505 operative repairs of genitourinary fistula were completed at 2 centers in Sierra Leone from 2004 to 2006. Statistical analysis of patient demographics, fistula characteristics, outcomes and surgical complications was performed.
  
  
  RESULTS
  Primary repairs, defined as the first repair, accounted for 68% of repairs in the population with 92% classified as vesicovaginal fistula alone. Only 56% of women were deemed to have an intact urethra at presentation and 68% were diagnosed with moderate or severe fibrosis surrounding the fistula. On univariate analysis parameters that demonstrated significant differences with primary operative success were patient age at fistula occurrence (p = 0.0192), index pregnancy (p = 0.0061), location (p <0.0001), surface area (p <0.0001), urethral status (p <0.0001) and fibrosis (p <0.0001). On multivariate analysis the fistula parameter that correlated with successful repair was the extent of fibrosis (severe fibrosis OR 3.7).
  
  
  CONCLUSIONS
  Genitourinary fistula as a result of prolonged obstructed labor is a cause of considerable morbidity in sub-Saharan Africa, including Sierra Leone. The most profound factor correlating with a positive operative outcome was the extent of fibrosis surrounding the fistula. These data are important to help predict the likelihood of successful repair and assist in selecting women for the appropriate surgical procedure.
authors.affiliation: West Africa Fistula Foundation, Choithram Memorial Hospital at Hill Station, Freetown, Sierra Leone.
authors.forename: Alyona
authors.initials: A
authors.lastname: Lewis
authors.forename: Melissa R
authors.initials: MR
authors.lastname: Kaufman
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Wolter
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Phillips
authors.forename: Darius
authors.initials: D
authors.lastname: Maggi
authors.forename: Leesa
authors.initials: L
authors.lastname: Condry
authors.forename: Roger R
authors.initials: RR
authors.lastname: Dmochowski
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005402:Fistula / Q000209:etiology / Q000601:surgery*; D005831:Genital Diseases, Female / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007744:Obstetric Labor Complications / Q000601:surgery*; D011247:Pregnancy; D012807:Sierra Leone; D014548:Urinary Fistula / Q000209:etiology / Q000601:surgery*; D055815:Young Adult