A novel three-component reaction for the synthesis of 3-aryl-4H-benzo [1,4] oxazin-2-amine.
A high yielding and fast method for the synthesis of 3-aryl-4H-benzo [1,4] oxazin-2-amine via one-pot, three component reaction of an aromatic aldehyde, isocyanide and o-aminophenol using p-toluene sulfonic acid as a catalyst is described.
Heravi
Majid M
MM
Department of Chemistry, School of Science, Alzahra University, Vanak, Tehran, Iran. mmh1331@yahoo.com
Baghernejad
Bita
B
Oskooie
Hossein A
HA
D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry; D000627:Aminophenols / Q000737:chemistry; D001557:Benzenesulfonates / Q000737:chemistry*; D048588:Benzoxazines / Q000138:chemical synthesis* / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry
D000447:Aldehydes; D000588:Amines; D000627:Aminophenols; D001557:Benzenesulfonates; D048588:Benzoxazines; D003486:Cyanides; C029501:4-toluenesulfonic acid