title: Prognostic significance of stromal eosinophilic infiltration in oral squamous cell carcinoma.
abstract: Tumor-associated tissue eosinophilia (TATE) has been described in many sites, including head and neck. The aim of this study was to investigate the prevalence and possible role of TATE as a prognostic factor in oral squamous cell carcinoma (OSCC). Seventy-six consecutive patients with a diagnosis of OSCC were evaluated, and the number of eosinophils was obtained in 3 different areas in the tumor. The possible role of TATE as a prognostic factor in OSCC was investigated with respect to tumor differentiation; perineural, vascular, and muscular invasion (histopathologic parameters); and locoregional metastasis (clinical parameter). Tumor-associated tissue eosinophilia was low in most cases in 3 different areas. The mean eosinophil count was higher in the invasive front of tumor than intratumoral stroma and stroma subjacent the surface epithelium. The relations between TATE and tumor differentiation; perineural, vascular, and muscular invasion; and locoregional metastasis were not statistically significant (P > 0.05). Tumor-associated tissue eosinophilia has no correlation with prognostic parameters in OSCC.
authors.affiliation: Department of Oral Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. andisheh202003@yahoo
authors.forename: Azadeh Andisheh
authors.initials: AA
authors.lastname: Tadbir
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Ashraf
authors.forename: Yasaman
authors.initials: Y
authors.lastname: Sardari
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000098:blood supply / Q000473:pathology* / Q000556:secondary; D002454:Cell Differentiation; D004802:Eosinophilia / Q000473:pathology*; D004804:Eosinophils / Q000473:pathology; D005260:Female; D006258:Head and Neck Neoplasms / Q000556:secondary; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000098:blood supply / Q000294:innervation; D009062:Mouth Neoplasms / Q000098:blood supply / Q000473:pathology*; D018482:Muscle, Skeletal / Q000473:pathology; D009361:Neoplasm Invasiveness; D011379:Prognosis; D017154:Stromal Cells / Q000473:pathology