title: Accuracy of velocity distortion product otoacoustic emissions for estimating mechanically based hearing loss.
abstract: Distortion product otoacoustic emissions (DPOAEs) measured as vibration of the human eardrum have been successfully used to estimate hearing threshold. The estimates have proved more accurate than similar methods using sound-pressure DPOAEs. Nevertheless, the estimation accuracy of the new technique might have been influenced by endogenous noise, such as heart beat, breathing and swallowing. Here, we investigate in an animal model to what extent the accuracy of the threshold estimation technique using velocity-DPOAEs might be improved by reducing noise sources. Velocity-DPOAE I/O functions were measured in normal and hearing-impaired anaesthetized guinea pigs. Hearing loss was either conductive or induced by furosemide injection. The estimated distortion product threshold (EDPT) obtained by extrapolation of the I/O function to the abscissa was found to linearly correlate with the compound action potential threshold at the f(2) frequency, provided that furosemide data were excluded. The standard deviation of the linear regression fit was 6 dB as opposed to 8 dB in humans, suggesting that this accuracy should be achievable in humans with appropriate improvement of signal-to-noise ratio. For the furosemide animals, the CAP threshold relative to the regression line provided an estimate of the functional loss of the inner hair cell system. For mechanical losses in the middle ear and/or cochlear amplifier, DPOAEs measured as velocity of the umbo promise an accuracy of hearing threshold estimation comparable to classical audiometry.
authors.affiliation: Eberhard-Karls-University Tübingen, Department Otolaryngology, Section of Physiological Acoustics and Communication, Elfriede-Aulhorn-Strasse 5, Tübingen 72076, Germany. diana.turcanu@uni-tuebingen.de
authors.forename: Diana
authors.initials: D
authors.lastname: Turcanu
authors.forename: Ernst
authors.initials: E
authors.lastname: Dalhoff
authors.forename: Marcus
authors.initials: M
authors.lastname: Müller
authors.forename: Hans-Peter
authors.initials: HP
authors.lastname: Zenner
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Gummer
mesh_terms: D000161:Acoustic Stimulation; D000200:Action Potentials; D000758:Anesthesia; D000818:Animals; D001299:Audiometry / Q000379:methods* / Q000592:standards*; D001309:Auditory Threshold; D004195:Disease Models, Animal; D004429:Ear Ossicles / Q000502:physiology; D005260:Female; D005665:Furosemide / Q000633:toxicity; D006168:Guinea Pigs; D006309:Hearing / Q000502:physiology; D006314:Hearing Loss, Conductive / Q000139:chemically induced / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D010034:Otitis Media with Effusion / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D017084:Otoacoustic Emissions, Spontaneous; D011304:Presbycusis / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D015203:Reproducibility of Results; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000633:toxicity; D014732:Vibration
chemical_list: D049994:Sodium Potassium Chloride Symporter Inhibitors; D005665:Furosemide