title: Treatment of invasive fungal infections: stability of voriconazole infusion solutions in PVC bags.
abstract: Voriconazole is a novel broad-spectrum antifungal drug, employed in the treatment of invasive fungal infections, and represents an alternative to amphotericin B treatment. The manufacturer recommends that any unused reconstituted product should be stored at 2 masculineC to 8 masculineC, for no more than 24 h, but no recommendations about i.v. infusion solutions are given. Previous works have reported on the stability of voriconazole in polyolefin bags and just one in 5% dextrose polyvinyl chloride (PVC) bags, at a 4 mg.mL-1 concentration. In this work, the stability of voriconazole as an i.v. infusion solution in 0.9% sodium chloride and in 5% dextrose, in PVC bags, at 0.5 mg.mL-1, stored at 4 masculineC and at room temperature, protected from light, was evaluated. These infusion solutions were analyzed for a 21-day period. Chemical stability was evaluated by HPLC assay. Visual inspection was performed and pH of the solutions was measured. No color change or precipitation in the solutions was observed. The drug content remained above 90% for 11 days in 0.9% sodium chloride and for 9 days in 5% dextrose solutions. The i.v. infusion solutions stored at room temperature were not stable. At room temperature, the voriconazole content dropped down to 88.3 and 86.6%, in 0.9% sodium chloride or 5% dextrose solutions, respectively, two days after admixture. Assays performed at the end of the study suggest the sorption of voriconazole by the PVC bags. The results of this study allow cost-effective batch production in the hospital pharmacy.
authors.affiliation: University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: Andréa I H
authors.initials: AI
authors.lastname: Adams
authors.forename: Lucia N
authors.initials: LN
authors.lastname: Morimoto
authors.forename: Leonardo Z
authors.initials: LZ
authors.lastname: Meneghini
authors.forename: Ana M
authors.initials: AM
authors.lastname: Bergold
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004349:Drug Packaging / Q000191:economics / Q000295:instrumentation*; D004355:Drug Stability; D004356:Drug Storage / Q000379:methods; D006863:Hydrogen-Ion Concentration; D007263:Infusions, Parenteral / Q000191:economics / Q000295:instrumentation; D009181:Mycoses / Q000188:drug therapy; D011090:Polyenes; D011143:Polyvinyl Chloride; D011743:Pyrimidines / Q000008:administration & dosage / Q000737:chemistry*; D013997:Time Factors; D014230:Triazoles / Q000008:administration & dosage / Q000737:chemistry*; D065819:Voriconazole
chemical_list: D000900:Anti-Bacterial Agents; D011090:Polyenes; D011743:Pyrimidines; D014230:Triazoles; C035051:PL 732; D011143:Polyvinyl Chloride; D065819:Voriconazole