title: A new on-axis multimode spectrometer for the macromolecular crystallography beamlines of the Swiss Light Source.
abstract: X-ray crystallography at third-generation synchrotron sources permits tremendous insight into the three-dimensional structure of macromolecules. Additional information is, however, often required to aid the transition from structure to function. In situ spectroscopic methods such as UV-Vis absorption and (resonance) Raman can provide this, and can also provide a means of detecting X-ray-induced changes. Here, preliminary results are introduced from an on-axis UV-Vis absorption and Raman multimode spectrometer currently being integrated into the beamline environment at X10SA of the Swiss Light Source. The continuing development of the spectrometer is also outlined.
authors.affiliation: Swiss Light Source, Paul Scherrer Institute, CH-5232 Villigen PSI, Switzerland.
authors.forename: Robin L
authors.initials: RL
authors.lastname: Owen
authors.forename: Arwen R
authors.initials: AR
authors.lastname: Pearson
authors.forename: Alke
authors.initials: A
authors.lastname: Meents
authors.forename: Pirmin
authors.initials: P
authors.lastname: Boehler
authors.forename: Vincent
authors.initials: V
authors.lastname: Thominet
authors.forename: Clemens
authors.initials: C
authors.lastname: Schulze-Briese
mesh_terms: D017076:Computer-Aided Design; D018360:Crystallography, X-Ray / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D046911:Macromolecular Substances / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013056:Spectrophotometry, Ultraviolet / Q000295:instrumentation* / Q000379:methods
chemical_list: D046911:Macromolecular Substances