First inflammatory risk score for aortic endoprostheses.
OBJECTIVE
To purpose an inflammatory risk score for aortic aneurysm endovascular treatment.


METHODS
Twenty-five patients were followed-up from preoperative period to third month postoperatively (1-hour, 6-hour, 24-hour, 48-hour, 7-day, 1-month, 2- month and 3month). Inflammatory variables were C-reactive protein, hemosedimentation velocity, interleukins (IL-6, IL-8), tumor necrosis factor-Alpha, L-selectin, intercellular adhesion molecule (ICAM-1), red blood cells transfusion, volume of crystalloid, volume of contrast, type of endoprosthesis, number of endoprostheses, total count of leukocytes and lymphocytes. Spearman test defined the variables considered as candidates to higher inflammatory risk based on P < 20%. Logistic regression defined the variables considered as selected for final score based on P < 10%. ROC curve analysis revealed the cut-off values for variables selected by logistic regression.


RESULTS
Variables defined by Spearman test were: volume of crystalloid (P=0.04), type of endoprosthesis (P=0.04), volume of contrast (P=0.02), preoperative IL-8 (P = 0.10), 1 - month ICAM-1 (P=0.03) and 1-month L-selectin (P=0.06). Logistic regression revealed that volume of crystalloid and preoperative IL-8 values are relevant for composition of inflammatory risk score for aortic aneurysm endovascular treatment. Risk score would be divided into three categories (mild, moderate and severe) based on numeric intervals of these two variables and the categories would be correlated to clinical findings.


CONCLUSIONS
Volume of crystalloid and preoperative IL-8 are variables that might contribute to categorize inflammatory risk and thereby might play a prognostic role for aortic aneurysm endovascular treatment.
Gabriel
Edmo Atique
EA
Universidade Federal de São Paulo and Heart Hospital of Sao Paulo, Sao Paulo, Brazil. edag@uol.com.br
Locali
Rafael Fagionato
RF
Matsoka
Priscila Katsumi
PK
Romano
Carla Cristina
CC
Duarte
Alberto José da Silva
AJ
Buffolo
Enio
E
D001014:Aortic Aneurysm / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects*; D001810:Blood Volume / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D016209:Interleukin-8 / Q000097:blood; D016015:Logistic Models; D008297:Male; D011182:Postoperative Care; D011300:Preoperative Care; D012372:ROC Curve; D018570:Risk Assessment; D018746:Systemic Inflammatory Response Syndrome / Q000209:etiology*
D015815:Cell Adhesion Molecules; D018836:Inflammation Mediators; D016209:Interleukin-8