Aromatase inhibitory fatty acid derivatives from the pollen of Brassica campestris L. var. oleifera DC.
Two new fatty acid derivatives, 9Z,12Z,15Z-octadecatrienoic acid sorbitol ester (1) and (10,11,12)-trihydroxy-(7Z,14Z)-heptadecadienoic acid (2), were isolated from the pollen of Brassica campestris L. var. oleifera DC., along with the four known fatty acid derivatives, 9Z,12Z,15Z-octadecatrienamide, N-(2-hydroxyethyl) (3), hexadecanoic acid sorbitol ester (4), 15,16-dihydroxy-9Z,12Z-octadecadienoic acid (5), and 9Z,12Z,15Z-octadecatrienoic acid 2,3-dihydroxypropyl ester (6). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-ESI-MS experiments. All compounds were tested using a noncellular aromatase assay, and the results showed that some compounds possessed strong inhibitory activity.
Yang
Nian-Yun
NY
Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai, China.
Li
Kun
K
Yang
Yi-Fang
YF
Li
Yong-Hui
YH
D047072:Aromatase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001937:Brassica / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011058:Pollen / Q000737:chemistry*; D013237:Stereoisomerism
C539684:(10,11,12)-trihydroxy-(7Z,14Z)-heptadecadienoic acid; C539683:9Z,12Z,15Z-octadecatrienoic acid sorbitol ester; D047072:Aromatase Inhibitors; D004365:Drugs, Chinese Herbal; D005231:Fatty Acids, Unsaturated