title: Towards an orientation-distribution-based multi-scale approach for remodelling biological tissues.
abstract: The mechanical behaviour of soft biological tissues is governed by phenomena occurring on different scales of observation. From the computational modelling point of view, a vital aspect consists of the appropriate incorporation of micromechanical effects into macroscopic constitutive equations. In this work, particular emphasis is placed on the simulation of soft fibrous tissues with the orientation of the underlying fibres being determined by distribution functions. A straightforward but convenient Taylor-type homogenisation approach links the micro- or rather meso-level of fibres to the overall macro-level and allows to reflect macroscopically orthotropic response. As a key aspect of this work, evolution equations for the fibre orientations are accounted for so that physiological effects like turnover or rather remodelling are captured. Concerning numerical applications, the derived set of equations can be embedded into a nonlinear finite element context so that first elementary simulations are finally addressed.
authors.affiliation: Division of Solid Mechanics, Lund University, P.O. Box 118, SE-221 00 Lund, Sweden. andreas.menzel@solid.lth.se
authors.forename: A
authors.initials: A
authors.lastname: Menzel
authors.forename: M
authors.initials: M
authors.lastname: Harrysson
authors.forename: M
authors.initials: M
authors.lastname: Ristinmaa
mesh_terms: D016880:Anisotropy; D001696:Biomechanical Phenomena; D001808:Blood Vessels / Q000502:physiology; D003198:Computer Simulation; D004548:Elasticity; D005109:Extracellular Matrix / Q000502:physiology; D020342:Finite Element Analysis; D008954:Models, Biological; D009132:Muscles / Q000502:physiology; D012879:Skin Physiological Phenomena