[Chorionic villus cell culture and karyotype analysis in 110 cases of early spontaneous abortion].
OBJECTIVE
To investigate the value of fetal chromosomal karyotype analysis in cases of early spontaneous abortion.


METHODS
Chorionic villus specimens obtained from 110 cases of early spontaneous abortion were cultured for karyotype analysis.


RESULTS
Of the 110 cases, chorionic villus was successfully cultured in 103 cases (93.7%), and abnormal embryo karyotypes were identified in 52 cases (50.5%). Trisomy was the most frequent embryo karyotype abnormalities in these cases, and chromosomal aberration occurred in 29 cases (52.9%) of the first spontaneous abortion and in 23 cases (42.6%) of repeated abortions. Female fetuses accounted for 75.5% (78 cases) in the spontaneously aborted fetuses and for 67.3% (35 cases) in fetuses with chromosomal abnormalities.


CONCLUSIONS
Embryo chromosomal abnormality is the most important reason of early spontaneous abortion, and karyotype analysis of the villus helps identify the causes of abortion and ensure the success of the next pregnancy.
Xiong
Li
L
Basic Medical Experiment Teaching Center, Southern Medical University, Guangzhou 510515, China.
Liu
Jie
J
Deng
Kang
K
Liu
Si-ping
SP
Jia
Bei
B
Wu
Rui-feng
RF
Zhong
Mei
M
Zeng
Rong
R
D000022:Abortion, Spontaneous / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D002478:Cells, Cultured; D002824:Chorionic Villi / Q000473:pathology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014314:Trisomy / Q000235:genetics