[Guiding and integrating to control and diversify splicing].
Recent studies directed at understanding alternative splicing control have produced an expanding list of regulators that can enhance or silence the use of splice sites by binding to specific sequences. A fine balance in the expression and the combinatorial use of these factors would help to adapt splicing decisions to a variety of situations. Additional levels of control are provided by tightly connecting the activity of alternative splicing factors with other cellular processes such as signal transduction and transcription. Combining classical experiments and high-throughput approaches is now confirming the important contribution of alternative splicing to proteomic diversity while helping to decipher the underlying networks of splicing regulation.
Fisette
Jean-François
JF
Chaire de recherche du Canada en génomique fonctionnelle, Groupe ARN, Département de microbiologie et d'infectiologie, Faculté de médecine et des sciences de la santé, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke, Québec J1H 5N4, Canada.
Michelle
Laetitia
L
Revil
Timothée
T
Chabot
Benoit
B
D017398:Alternative Splicing / Q000235:genetics*; D000818:Animals; D005786:Gene Expression Regulation; D014644:Genetic Variation; D006706:Homeostasis; D006801:Humans; D008957:Models, Genetic; D011401:Promoter Regions, Genetic; D020543:Proteome; D012322:RNA Precursors / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D020543:Proteome; D012322:RNA Precursors; D012333:RNA, Messenger