SUMO weighs in on a photoreceptor finish.
In the developing retina the nuclear hormone receptor Nr2e3 has dual roles, promoting expression of rod-specific genes and repressing expression of cone specific genes. In a recent issue of Neuron, Onishi et al. show that PIAS3-mediated SUMOylation of Nr2e3 plays an essential role in the specification of rod photoreceptors by converting Nr2e3 to a potent repressor of cone gene expression.
LaBonne
Carole
C
D000818:Animals; D015509:Developmental Biology / Q000379:methods; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D057093:Orphan Nuclear Receptors; D010786:Photoreceptor Cells / Q000502:physiology; D050828:Protein Inhibitors of Activated STAT / Q000378:metabolism*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D012160:Retina / Q000196:embryology*; D017949:Retinal Cone Photoreceptor Cells / Q000378:metabolism; D017948:Retinal Rod Photoreceptor Cells / Q000378:metabolism; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*
D018832:Molecular Chaperones; C485736:Nr2e3 protein, mouse; D057093:Orphan Nuclear Receptors; C484745:PIAS3 protein, human; D050828:Protein Inhibitors of Activated STAT; D018160:Receptors, Cytoplasmic and Nuclear; D025841:Small Ubiquitin-Related Modifier Proteins