title: Adolescent obesity: etiology, office evaluation, and treatment.
abstract: Coronary artery disease is the most common cause of death in the United States and the leading cause of hospital-related health care costs. Hypercholesterolemia is a leading risk factor for cardiovascular disease, and both genetic and environmental factors affect cholesterol levels. Although the clinical symptoms and signs of elevated cholesterol levels in children do not occur until adulthood, arterial dysfunction and plaque formation begin much earlier. Thirty-six percent of US youth have a cholesterol level that is higher than normal (>170 mg/dL), with elevated low-density lipoprotein levels associated with atherosclerotic lesions and ultimate disease. Because the disease process begins in childhood and adolescence, early prevention in childhood is critically important. Currently, universal cholesterol screening of adolescents is the most cost-effective method of identifying individuals with familial hypercholesterolemia who need intensive and early preventive care.
authors.affiliation: Division of Adolescent Medicine, Department of Pediatrics, Stanford University School of Medicine, 1174 Castro Street, Suite 250A, Mountain View, CA 94040, USA. rpeebles@stanford.edu
authors.forename: Rebecka
authors.initials: R
authors.lastname: Peebles
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D041923:Adolescent Development / Q000502:physiology; D002648:Child; D002657:Child Development / Q000502:physiology; D015897:Comorbidity; D004032:Diet / Q000379:methods; D015444:Exercise / Q000502:physiology; D005190:Family; D020022:Genetic Predisposition to Disease; D006801:Humans; D015596:Nutrition Assessment; D009765:Obesity / Q000150:complications / Q000209:etiology* / Q000628:therapy*; D050177:Overweight / Q000150:complications / Q000209:etiology / Q000628:therapy; D010808:Physical Examination / Q000379:methods*; D012307:Risk Factors; D015431:Weight Loss