title: The influence of (18)flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma.
abstract: BACKGROUND
  The influence of positron emission tomography (PET) scanning with flourodeoxyglucose (FDG) on decision making for the treatment of patients with esophagogastric junction (EGJ) carcinoma is unclear as is the utility of the maximum standardized uptake value (SUV) as a prognostic indicator.
  
  
  METHODS
  This study was a retrospective review of EGJ carcinoma cases at a single institution during a 5-year period.
  
  
  RESULTS
  FDG-PET altered treatment in 13 of 64 patients (20%). Of these, 21 patients had PET scans before and after undergoing neoadjuvant chemoradiation (CRT) as well as surgery. Patients who had a decrease in SUV >50% had a 12-month disease-free survival advantage over patients a decrease in SUV <50% (93% vs 43%, P = .025).
  
  
  CONCLUSIONS
  FDG-PET alters treatment in a significant number of patients with EGJ carcinoma. A >50% decrease in SUV after CRT is associated with an improved prognosis.
authors.affiliation: Department of Surgery, Loyola University Medical Center, Maywood, IL, USA.
authors.forename: Jason W
authors.initials: JW
authors.lastname: Smith
authors.forename: Jonathan
authors.initials: J
authors.lastname: Moreira
authors.forename: Gerard
authors.initials: G
authors.lastname: Abood
authors.forename: Gerard V
authors.initials: GV
authors.lastname: Aranha
authors.forename: Suneel
authors.initials: S
authors.lastname: Nagda
authors.forename: Robert H
authors.initials: RH
authors.lastname: Wagner
authors.forename: Margo
authors.initials: M
authors.lastname: Shoup
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging* / Q000628:therapy; D000368:Aged; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy; D004943:Esophagogastric Junction; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000000981:diagnostic imaging* / Q000628:therapy
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18