Amnestic mild cognitive impairment in Parkinson's disease: a brain perfusion SPECT study.
The purpose of this study was to investigate cortical dysfunction in Parkinson's disease (PD) patients with amnestic deficit (PD-MCI). Perfusion single photon emission computed tomography was performed in 15 PD-MCI patients and compared (statistical parametric mapping [SPM2]) with three groups, i.e., healthy subjects (CTR), cognitively intact PD patients (PD), and common amnestic MCI patients (aMCI). Age, depression, and UPDRS-III scores were considered as confounding variables. PD-MCI group (P < 0.05, false discovery rate-corrected for multiple comparisons) showed relative hypoperfusion in bilateral posterior parietal lobe and in right occipital lobe in comparison to CTR. As compared to aMCI, MCI-PD demonstrated hypoperfusion in bilateral posterior parietal and occipital areas, mainly right cuneus and angular gyrus, and left precuneus and middle occipital gyrus. With a less conservative threshold (uncorrected P < 0.01), MCI-PD showed hypoperfusion in a left parietal region, mainly including precuneus and inferior parietal lobule, and in a right temporal-parietal-occipital region, including middle occipital and superior temporal gyri, and cuneus-precuneus, as compared to PD. aMCI versus PD-MCI showed hypoperfusion in bilateral medial temporal lobe, anterior cingulate, and left orbitofrontal cortex. PD-MCI patients with amnestic deficit showed cortical dysfunction in bilateral posterior parietal and occipital lobes, a pattern that can be especially recognized versus both controls and common aMCI patients, and to a lesser extent versus cognitively intact PD. The relevance of this pattern in predicting dementia should be evaluated in longitudinal studies.
Nobili
Flavio
F
Clinical Neurophysiology (DISEM, DipTeC), University of Genoa, Genoa, Italy. flaviomariano.nobili@hsanmartino.it
Abbruzzese
Giovanni
G
Morbelli
Silvia
S
Marchese
Roberta
R
Girtler
Nicola
N
Dessi
Barbara
B
Brugnolo
Andrea
A
Canepa
Cinzia
C
Drosos
Giorgos Chr
GC
Sambuceti
Gianmario
G
Rodriguez
Guido
G
D000368:Aged; D000369:Aged, 80 and over; D000647:Amnesia / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000502:physiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000453:epidemiology* / Q000503:physiopathology*; D012720:Severity of Illness Index; D015899:Tomography, Emission-Computed, Single-Photon