[Gene expression analyses of kidney biopsies: the European renal cDNA bank--Kröner-Fresenius biopsy bank].
Histological analysis of kidney biopsies is an essential part of our current diagnostic workup of patients with renal disease. Besides the already established diagnostic tools, new methods allow extensive analysis of the sample tissue's gene expression. Using results from a European multicenter study on gene expression analysis of renal biopsies, in this review we demonstrate that this novel approach not only expands the scope of so-called basic research but also might supplement future biopsy diagnostics. The goals are improved diagnosis and more specific therapy choice and prognosis estimates.
Cohen
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Klinik für Nephrologie und Institut für Physiologie mit Zentrum für integrative Humanphysiologie, Universitätsspital und Universität Zürich, Zürich, Schweiz. clemens.cohen@usz.ch
Kretzler
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D030541:Databases, Genetic; D030561:Databases, Nucleic Acid; D005060:Europe; D015870:Gene Expression; D006801:Humans; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D011379:Prognosis; D040901:Proteomics; D012313:RNA / Q000235:genetics
D012313:RNA