Preliminary report: Serum levels of retinol-binding protein 4 in preeclampsia.
The objective of the study was to investigate serum levels of the adipokine retinol-binding protein 4 (RBP4) in patients with preeclampsia (PE) as compared with healthy controls of similar gestational age. Retinol-binding protein 4 serum levels were quantified by enzyme-linked immunosorbent assay in control (n = 20) and PE (n = 16) patients. Mean maternal RBP4 concentrations were not significantly different in PE (24.5 mg/L) as compared with controls (22.3 mg/L). Furthermore, RBP4 did not correlate to clinical and biochemical measures of pregnancy outcome, renal function, glucose, and lipid metabolism, as well as inflammation. Our results do not support a role of RBP4 in the pathogenesis of PE.
Stepan
Holger
H
Department of Obstetrics, University of Leipzig, Leipzig 04103, Germany.
Ebert
Thomas
T
Schrey
Susanne
S
Reisenbüchler
Constanze
C
Blüher
Matthias
M
Stumvoll
Michael
M
Kratzsch
Jürgen
J
Tönnessen
Patricia
P
Faber
Renaldo
R
Fasshauer
Mathias
M
D054392:Adipokines / Q000097:blood; D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood; D007231:Infant, Newborn; D007677:Kidney Function Tests; D008055:Lipids / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011507:Proteinuria / Q000097:blood; D012016:Reference Values; D054839:Retinol-Binding Proteins, Plasma / Q000378:metabolism*
D054392:Adipokines; D001786:Blood Glucose; D008055:Lipids; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma