title: Effect of megestrol acetate on serum albumin level in malnourished dialysis patients.
abstract: OBJECTIVE
  Malnutrition is a common problem in dialysis patients, and may affect up to one third of patients. It is associated with high mortality and morbidity. Although a number of studies were performed to determine effective treatment, there is no proven medication for this condition. This study aimed to evaluate the effect of megestrol acetate (MA) on serum albumin levels in malnourished dialysis patients.
  
  
  METHODS
  This was a randomized, controlled clinical trial.
  
  
  METHODS
  The setting, a dialysis center at Razi Hospital, Rasht, Iran, provides services to dialysis patients.
  
  
  METHODS
  Twenty-two malnourished dialysis patients with persistent hypoalbuminemia (albumin, <3.5 g/dL for 2 months) participated, and were randomly assigned to either an experimental group or a control group.
  
  
  METHODS
  The experimental group was treated with MA, 40 mg twice daily, over 2 months, and was compared with the control group. The collected data were analyzed using SPSS (version 10; Chicago, IL).
  
  
  RESULTS
  After 2 months, the mean (+/-SD) serum albumin level in the experimental group rose from 3.31 +/- 0.31 g/dL to 4.41 +/- 0.31 g/dL, but in the control group, it declined, from 3.35 +/- 0.21 to 3.02 +/- 0.48 g/dL. The difference between the two groups was significant (P = .002).
  
  
  CONCLUSIONS
  At a dose of 40 mg twice a day, MA safely increased serum albumin in malnourished dialysis patients.
authors.affiliation: Urology Research Center, Razi Hospital, Rasht, Iran. urc1384@yahoo.com
authors.forename: Ali
authors.initials: A
authors.lastname: Monfared
authors.forename: Abtin
authors.initials: A
authors.lastname: Heidarzadeh
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghaffari
authors.forename: Marzieh
authors.initials: M
authors.lastname: Akbarpour
mesh_terms: D019167:Appetite Stimulants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D044342:Malnutrition / Q000097:blood* / Q000517:prevention & control; D019290:Megestrol Acetate / Q000494:pharmacology*; D008875:Middle Aged; D009752:Nutritional Status; D006435:Renal Dialysis; D012709:Serum Albumin / Q000187:drug effects* / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D019167:Appetite Stimulants; D015415:Biomarkers; D012709:Serum Albumin; D019290:Megestrol Acetate