Icosahedral DNA nanocapsules by modular assembly.
It's a trap! DNA polyhedra formed through molecular self-assembly may function as nanocapsules for the targeted delivery of encapsulated entities. This functional aspect was demonstrated for the most complex DNA-based platonic solid: During the stepwise amalgamation of discrete polyhedra to form icosahedra, gold nanoparticles (GNPs) were encapsulated from solution (see illustration and TEM image of icosahedral cages containing GNPs).
Bhatia
Dhiraj
D
National Centre for Biological Sciences, TIFR, GKVK, Bellary Road, Bangalore, 560 065, India.
Mehtab
Shabana
S
Krishnan
Ramya
R
Indi
Shantinath S
SS
Basu
Atanu
A
Krishnan
Yamuna
Y
D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D009690:Nucleic Acid Conformation
D053769:Nanocapsules; D006046:Gold; D004247:DNA