Mammalian PGRPs in the spotlight.
Peptidoglycan-recognition proteins (PGRPs) play a central role in the insect innate immune response to bacteria. In this issue of Cell Host & Microbe, Saha et al. (2009) report that the mammalian PGRP, PGLYRP-2, functions as a cytokine-like molecule in a PG-induced arthritis model.
Boneca
Ivo Gomperts
IG
Institut Pasteur, Group of Biology and Genetics of the Bacterial Cell Wall, Paris, France. bonecai@pasteur.fr
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001419:Bacteria / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology*; D008322:Mammals / Q000276:immunology*; D051379:Mice; D009238:N-Acetylmuramoyl-L-alanine Amidase; D011506:Proteins / Q000276:immunology*
D011506:Proteins; D009238:N-Acetylmuramoyl-L-alanine Amidase; C416533:Pglyrp2 protein, mouse