A putative ABC transporter confers durable resistance to multiple fungal pathogens in wheat.
Agricultural crops benefit from resistance to pathogens that endures over years and generations of both pest and crop. Durable disease resistance, which may be partial or complete, can be controlled by several genes. Some of the most devastating fungal pathogens in wheat are leaf rust, stripe rust, and powdery mildew. The wheat gene Lr34 has supported resistance to these pathogens for more than 50 years. Lr34 is now shared by wheat cultivars around the world. Here, we show that the LR34 protein resembles adenosine triphosphate-binding cassette transporters of the pleiotropic drug resistance subfamily. Alleles of Lr34 conferring resistance or susceptibility differ by three genetic polymorphisms. The Lr34 gene, which functions in the adult plant, stimulates senescence-like processes in the flag leaf tips and edges.
Krattinger
Simon G
SG
Institute of Plant Biology, University of Zurich, Zollikerstrasse 107, 8008 Zurich, Switzerland.
Lagudah
Evans S
ES
Spielmeyer
Wolfgang
W
Singh
Ravi P
RP
Huerta-Espino
Julio
J
McFadden
Helen
H
Bossolini
Eligio
E
Selter
Liselotte L
LL
Keller
Beat
B
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D000595:Amino Acid Sequence; D001203:Ascomycota / Q000235:genetics / Q000472:pathogenicity*; D001487:Basidiomycota / Q000235:genetics / Q000472:pathogenicity*; D002874:Chromosome Mapping; D032461:Chromosomes, Plant / Q000235:genetics; D003001:Cloning, Molecular; D005091:Exons; D017343:Genes, Plant; D007113:Immunity, Innate; D008969:Molecular Sequence Data; D009154:Mutation; D010935:Plant Diseases / Q000276:immunology / Q000382:microbiology; D018515:Plant Leaves / Q000382:microbiology; D010940:Plant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D014908:Triticum / Q000235:genetics* / Q000254:growth & development / Q000276:immunology / Q000382:microbiology*
D018528:ATP-Binding Cassette Transporters; D010940:Plant Proteins