title: Vapour-phase hydrogen peroxide inactivates Yersinia pestis dried on polymers, steel, and glass surfaces.
abstract: OBJECTIVE
  This study evaluated the inactivation of virulent Yersinia pestis dried on polymers, steel, and glass surfaces using vapour-phase hydrogen peroxide.
  
  
  RESULTS
  A suspension of Y. pestis CO92 (1.70 x 10(8) CFU) was dried on 10 different types of test surfaces and exposed to vapour-phase hydrogen peroxide fumigation for a contact time of 2 h. A significant reduction in the log10 CFU of Y. pestis on all 10 materials was observed between the controls evaluated after a 1 h drying time and unexposed controls evaluated after the decontamination run. Qualitative growth assessment showed that vapour-phase hydrogen peroxide exposure inactivated Y. pestis on all replicates of the 10 test materials as well as biological indicators up to 7 days postexposure.
  
  
  CONCLUSIONS
  Virulent Y. pestis CO92 is inactivated on polymers, steel, and glass surfaces when exposed to vapour-phase hydrogen peroxide without observable physical damage to the test materials.
  
  
  CONCLUSIONS
  This study provides information for using vapour-phase hydrogen peroxide as a practical process for the decontamination of virulent Y. pestis in circumstances where time-dependent attenuation/inactivation orliquid/heat decontamination may not be the most suitable approach.
authors.affiliation: Battelle Biomedical Research Center, 505 King Avenue, JM-7, Columbus, OH 43201, USA. rogersjv@battelle.org
authors.forename: J V
authors.initials: JV
authors.lastname: Rogers
authors.forename: W R
authors.initials: WR
authors.lastname: Richter
authors.forename: M Q
authors.initials: MQ
authors.lastname: Shaw
authors.forename: Y W
authors.initials: YW
authors.lastname: Choi
mesh_terms: D003666:Decontamination / Q000379:methods; D003890:Desiccation; D004202:Disinfectants / Q000494:pharmacology*; D004866:Equipment Contamination; D005898:Glass; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008422:Materials Testing / Q000379:methods; D011108:Polymers; D013232:Steel; D015010:Yersinia pestis / Q000187:drug effects* / Q000254:growth & development
chemical_list: D004202:Disinfectants; D011108:Polymers; D013232:Steel; D006861:Hydrogen Peroxide