Antiproliferative effects of peracetylated naphthoxylosides.
The antiproliferative activity, and the capability of priming of glycosaminoglycan chains, of two series of peracetylated mono- and bis-xylosylated dihydroxynaphthalenes have been investigated for normal HFL-1 cells, as well as transformed T24 cells, and compared to the unprotected analogs. Our data show increased antiproliferative activity upon peracetylation, but a loss of selectivity towards T24 cells.
Nilsson
Ulrika
U
Organic Chemistry, Lund University, PO Box 124, SE-221 00 Lund, Sweden.
Jacobsson
Mårten
M
Johnsson
Richard
R
Mani
Katrin
K
Ellervik
Ulf
U
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002461:Cell Line, Transformed; D049109:Cell Proliferation / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D006025:Glycosaminoglycans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D008956:Models, Chemical; D015394:Molecular Structure; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D006025:Glycosaminoglycans; D006027:Glycosides; D009281:Naphthalenes; C010807:xylosides