Fibroblast growth factor expression during skeletal fracture healing in mice.
Fibroblast growth factors (FGFs) are important signaling molecules that regulate many stages of endochondral bone development. During the healing of a skeletal fracture, several features of endochondral bone development are reactivated. To better understand the role of FGFs in skeletal fracture healing, we quantitatively evaluated the temporal expression patterns of Fgfs, Fgf receptors (Fgfrs), and molecular markers of bone development over a 14-day period following long bone fracture in a mouse model. These studies identify distinct groups of FGFs that are differentially expressed and suggest active stage-specific roles for FGF signaling during the fracture repair process.
Schmid
Gregory J
GJ
Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Kobayashi
Chikashi
C
Sandell
Linda J
LJ
Ornitz
David M
DM
D000818:Animals; D019902:Chondrocytes / Q000378:metabolism; D004195:Disease Models, Animal; D005260:Female; D005346:Fibroblast Growth Factors / Q000235:genetics / Q000378:metabolism*; D017102:Fracture Healing / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D011859:Radiography; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D013997:Time Factors
D005346:Fibroblast Growth Factors