title: Comparison of systemic toxicities of 177Lu-DOTMP and 153Sm-EDTMP administered intravenously at equivalent skeletal doses to normal dogs.
abstract: Bone-seeking radiopharmaceuticals have been used to effectively treat cancer arising from and metastasizing to bone in humans and dogs. The rate of complete tumor control is low, and the geographic distribution of available compounds is limited by their half-lives. This experiment was done to evaluate in normal dogs the toxicity of (177)Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethylene phosphonate ((177)Lu-DOTMP) used as a potential therapeutic radiopharmaceutical.
  
  
  METHODS
  Four normal purpose-bred dogs were administered (177)Lu-DOTMP at a dose of 8.14 MBq/kg and monitored for 84 d for evidence of toxicity in the bone marrow and vital organs.
  
  
  RESULTS
  No statistically significant alterations in the biochemical profile, white blood cell count, or platelet count were observed in any dog. Very mild decreases in the red cell count were seen on day 84. No microscopic evidence of toxicity was present at necropsy.
  
  
  CONCLUSIONS
  The dogs receiving (177)Lu-DOTMP tolerated the administration and the effects of the compound without apparent clinical toxicity. The results of this experiment support the further evaluation in tumor-bearing dogs of (177)Lu-DOTMP as a potential therapy for metastatic bone cancer and primary bone tumors in humans and dogs.
authors.affiliation: Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, USA. bryanjn@vetmed.wsu.edu
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Bryan
authors.forename: David
authors.initials: D
authors.lastname: Bommarito
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Kim
authors.forename: Linda M
authors.initials: LM
authors.lastname: Berent
authors.forename: Margaret E
authors.initials: ME
authors.lastname: Bryan
authors.forename: Jimmy C
authors.initials: JC
authors.lastname: Lattimer
authors.forename: Carolyn J
authors.initials: CJ
authors.lastname: Henry
authors.forename: Hendrik
authors.initials: H
authors.lastname: Engelbrecht
authors.forename: Alan
authors.initials: A
authors.lastname: Ketring
authors.forename: Cathy
authors.initials: C
authors.lastname: Cutler
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000528:radiation effects; D001859:Bone Neoplasms / Q000532:radiotherapy; D004285:Dogs; D005260:Female; D008187:Lutetium; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000627:therapeutic use / Q000633:toxicity*; D011829:Radiation Dosage; D011868:Radioisotopes; D012493:Samarium
chemical_list: C531954:177Lu-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid); D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D011868:Radioisotopes; D012493:Samarium; D008187:Lutetium; C061972:samarium Sm-153 lexidronam