title: Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE study.
abstract: There is suggestive, but inconclusive, evidence that dietary factors may affect risk of cancers of the upper aerodigestive tract (UADT). In the context of the alcohol-related cancers and genetic susceptibility in Europe study, we have examined the association of dietary factors with UADT cancer risk. We have analyzed data from 2,304 patients with UADT cancer and 2,227 control subjects recruited in 14 centers in 10 European countries. Dietary data were collected through a semi-quantitative food frequency questionnaire that also assessed preferred temperature of hot beverages. Statistical analyses were conducted through multiple logistic regression controlling for potential confounding variables, including alcohol intake and smoking habits. Consumption of red meat (OR per increasing tertile = 1.14, 95% CI: 1.05-1.25), but not poultry, was significantly associated with increased UADT cancer risk and the association was somewhat stronger for esophageal cancer. Consumption of fruits (OR per increasing tertile = 0.68, 95% CI: 0.62-0.75) and vegetables (OR per increasing tertile = 0.73, 95% CI: 0.66-0.81) as well as of olive oil (OR for above versus below median = 0.78, 95% CI 0.67-0.90) and tea (OR for above versus below median = 0.83, 95% CI 0.69-0.98) were significantly associated with reduced risk of UADT cancer. There was no indication that an increase in tea or coffee temperature was associated with increased risk of UADT overall or cancer of the esophagus; in fact, the association was, if anything, inverse. In conclusion, the results of this large multicentric study indicate that diet plays an important role in the etiology of UADT cancer.
authors.affiliation: Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece. pdlagiou@med.uoa.gr
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Evangelia
authors.initials: E
authors.lastname: Samoli
authors.forename: Areti
authors.initials: A
authors.lastname: Lagiou
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Ahrens
authors.forename: Hermann
authors.initials: H
authors.lastname: Pohlabeln
authors.forename: Simone
authors.initials: S
authors.lastname: Benhamou
authors.forename: Christine
authors.initials: C
authors.lastname: Bouchardy
authors.forename: Alena
authors.initials: A
authors.lastname: Slamova
authors.forename: Miriam
authors.initials: M
authors.lastname: Schejbalova
authors.forename: Franco
authors.initials: F
authors.lastname: Merletti
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Richiardi
authors.forename: Kristina
authors.initials: K
authors.lastname: Kjaerheim
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.forename: Xavier
authors.initials: X
authors.lastname: Castellsague
authors.forename: Tatiana V
authors.initials: TV
authors.lastname: Macfarlane
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Macfarlane
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Biggs
authors.forename: Luigi
authors.initials: L
authors.lastname: Barzan
authors.forename: Cristina
authors.initials: C
authors.lastname: Canova
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Simonato
authors.forename: Raymond J
authors.initials: RJ
authors.lastname: Lowry
authors.forename: David I
authors.initials: DI
authors.lastname: Conway
authors.forename: Patricia A
authors.initials: PA
authors.lastname: McKinney
authors.forename: Ariana
authors.initials: A
authors.lastname: Znaor
authors.forename: Bernard E
authors.initials: BE
authors.lastname: McCartan
authors.forename: Claire M
authors.initials: CM
authors.lastname: Healy
authors.forename: Manuela
authors.initials: M
authors.lastname: Marron
authors.forename: Mia
authors.initials: M
authors.lastname: Hashibe
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
mesh_terms: D016022:Case-Control Studies; D004032:Diet; D004938:Esophageal Neoplasms / Q000209:etiology*; D005060:Europe; D005260:Female; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D008297:Male