Antinociceptive effects of 14-membered cyclopeptide alkaloids.
The analgesic potential of six 14-membered-ring cyclopeptide alkaloids, namely, franganine (1), discarine B (2), scutianines B (3), C (4), and D (5), and adouetine X (6), have been investigated. Among the compounds tested, only franganine (1) and adouetine X (6) produced antinociceptive effects in a mouse model of acute pain, without inducing undesirable side effects. Furthermore, compound 6 also exhibited a pronounced analgesic effect in a chronic neuropathic pain model in mice. It has been found that adouetine X (6) can decrease the activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase in vitro. Thus, the present findings have demonstrated that adouetine X (6) is a promising analgesic agent.
Trevisan
Gabriela
G
Departamento de Quimica, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Maldaner
Graciela
G
Velloso
Nádia Aléssio
NA
Sant'Anna
Gabriela da Silva
Gda S
Ilha
Vinicius
V
Velho Gewehr
Camila de Campos
Cde C
Rubin
Maribel Antonello
MA
Morel
Ademir Farias
AF
Ferreira
Juliano
J
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000700:Analgesics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D004195:Disease Models, Animal; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D051379:Mice; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D027823:Rhamnaceae / Q000737:chemistry*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D000470:Alkaloids; D000700:Analgesics; D010456:Peptides, Cyclic; C540531:adouetine X; C540530:franganine; C007533:discarine B; D000252:Calcium-Transporting ATPases; D000254:Sodium-Potassium-Exchanging ATPase