title: Nephropathia epidemica and leptospirosis in Champagne-Ardenne, France: comparison of clinical, biological and epidemiological profiles.
abstract: In the present retrospective study, we described a series of 45 non-icteric leptospirosis and 44 nephropathia epidemica (NE) patients diagnosed in the northeast of France from 1995 to 2005 and compared their clinical picture and laboratory parameters, as well as some epidemiological data. Loin pain (P < 0.001), abdominal pains (P = 0.007), rise of blood pressure (P < 0.001) and pharyngitis (P = 0.01) were more frequently found in NE patients. Aspartate aminotransferase (ASAT) (P = 0,006), creatine phosphokinase (CPK) (P < 0.0001) and C-reactive protein (CRP) (P < 0.0001) were higher in leptospirosis, whereas creatinine (P = 0.009) was higher in NE. Leptospirosis mainly concerns occupational hazards, e.g. farmers, and leisure activities like swimming, and NE concerns professional foresters or leisure activities in the forest and the cleaning of attics. During hospitalisation, patients receiving antibiotics were more frequent among leptospirosis than among NE patients (80% versus 59%, P = 0.06). Among the various common clinical signs, only acute myopia appeared to be a pathognomonic but inconsistently observed clinical sign, which was only observed in 47% of NE cases.
authors.affiliation: Service de Médecine Interne et des Maladies Infectieuses, CHU Reims-Hôpital Robert Debré, Avenue du Général Koenig, 51093, Reims Cedex, France. cstrady@chu-reims.fr
authors.forename: C
authors.initials: C
authors.lastname: Strady
authors.forename: C
authors.initials: C
authors.lastname: Penalba
authors.forename: S
authors.initials: S
authors.lastname: Baumard
authors.forename: V
authors.initials: V
authors.lastname: Brodard
authors.forename: A
authors.initials: A
authors.lastname: Wynckel
authors.forename: C
authors.initials: C
authors.lastname: Auvray
authors.forename: R
authors.initials: R
authors.lastname: Jaussaud
authors.forename: L
authors.initials: L
authors.lastname: Andreoletti
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005602:France / Q000453:epidemiology; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007922:Leptospirosis / Q000453:epidemiology* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult