title: Neuropsychologic status at the age 4 years and atopy in a population-based birth cohort.
abstract: BACKGROUND
  Mental health has been reported to be associated with allergy, but only a few cohort studies have assessed if neurodevelopment predicts atopy.
  
  
  OBJECTIVE
  To investigate if neurobehavioral status of healthy 4-year-old children was associated with specific immunoglobulin E (IgE) at the same age and skin prick test results 2 years later.
  
  
  METHODS
  A population-based birth cohort enrolled 482 children, 422 of them (87%) provided neurobehavioral data, 341 (71%) had specific IgE measured at the age of 4 years; and 395 (82%) had skin prick tests completed at the age of 6 years. Atopy was defined as IgE levels higher than 0.35 kU/l to any of the three tested allergens at the age of 4 or as a positive skin prick test to any of the six tested allergens at the age of 6. McCarthy Scales of Child Abilities and California Preschool Social Competence Scale were the psychometric instruments used.
  
  
  RESULTS
  Twelve percent of children at the age of 4 and 17% at the age of 6 were atopic. Neurobehavioral scores were negatively associated with 6-year-old atopy after adjustment for socio-demographic and allergic factors, A relative risk of 3.06 (95% CI: 1.30-7.24) was associated with the lowest tertile (scorings < or =90 points) of the general cognitive scale. Similar results were found for verbal abilities, executive functions, and social competence. Asthma, wheezing, rhinitis, and eczema at the age of 6, but not at the age of 4, were associated with neurodevelopment at the age of 4.
  
  
  CONCLUSIONS
  Neuropsychologic functioning and later atopy are negatively associated in preschool age children.
authors.affiliation: Centre for Research in Environmental Epidemiology, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Julvez
authors.forename: M
authors.initials: M
authors.lastname: Torrent
authors.forename: M
authors.initials: M
authors.lastname: Guxens
authors.forename: J M
authors.initials: JM
authors.lastname: Antó
authors.forename: S
authors.initials: S
authors.lastname: Guerra
authors.forename: J
authors.initials: J
authors.lastname: Sunyer
mesh_terms: D001519:Behavior; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D003071:Cognition; D015331:Cohort Studies; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology / Q000523:psychology*; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D009483:Neuropsychological Tests; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E