Genomic profiling of breast cancer.
Genome study provides significant changes in the advancement of molecular diagnosis and treatment in Breast cancer. Several recent critical advances and high-throughput techniques identified the genomic trouble and dramatically accelerated the pace of research in preventing and curing this malignancy. Tumor-suppressor genes, proto-oncogenes, DNA-repair genes, carcinogen-metabolism genes are critically involved in progression of breast cancer. We reviewed imperative finding in breast genetics, ongoing work to segregate further susceptible genes, and preliminary studies on molecular profiling.
Pandey
Anjita
A
Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
Singh
Alok Kumar
AK
Maurya
Sanjeev Kumar
SK
Rai
Rajani
R
Tewari
Mallika
M
Kumar
Mohan
M
Shukla
Hari S
HS
D001943:Breast Neoplasms / Q000235:genetics*; D002273:Carcinogens / Q000378:metabolism; D002877:Chromosomes, Human; D019175:DNA Methylation; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D015894:Genome, Human; D006801:Humans; D019656:Loss of Heterozygosity; D011519:Proto-Oncogenes
D002273:Carcinogens