[The pleiotropic effects of losartan--the importance of decreasing uric acid level].
Nowdays the goal of the antihypertensive treatment is to decrease the cardiovascular risk of the patients by treating the associated diseases and possible hypertensive end-organ damages. Losartan is an antihypertensive drug with all these capabilities and placebo-like side-effect profile. Besides the most important effects of losartan, which are mediated by blocking the angiotensin II. type 1. receptors, it also has other, molecule specific beneficial effects. The most important, well documented pleiotropic effect of losartan is its uricosuric effect. The pleiotropic effects together with the blockade of the angiotensin II. receptors are considered more and more important in the hypertensive end-organ protection and in the treatment of associated diseases in hypertensive patients.
Csiky
Botond
B
Pécsi Tudományegyetem, II. Sz. Belgyógyászati Klinika es Nefrológiai Centrum, H-7624 Pécs. botond.csiky@gmail.hu
Markó
Lajos
L
Mohás
Márton
M
Cseh
Judit
J
Mikolás
Esztella
E
Szíjártó
István
I
Wittmann
István
I
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D019808:Losartan / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood / Q000652:urine; D014528:Uricosuric Agents / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D014528:Uricosuric Agents; D014527:Uric Acid; D019808:Losartan