A reduced SNARE model for membrane fusion.
Let's get together: A minimal model system was developed to mimic the SNARE-protein-mediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled-coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events.
Robson Marsden
Hana
H
Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
Elbers
Nina A
NA
Bomans
Paul H H
PH
Sommerdijk
Nico A J M
NA
Kros
Alexander
A
D000595:Amino Acid Sequence; D002942:Circular Dichroism; D036341:Intercellular Signaling Peptides and Proteins; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008561:Membrane Fusion; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D050600:SNARE Proteins / Q000737:chemistry*
D036341:Intercellular Signaling Peptides and Proteins; D008051:Lipid Bilayers; D008081:Liposomes; D010455:Peptides; D050600:SNARE Proteins; C043948:lipid-associating peptides