title: Fluorescence-guided bone resection in bisphosphonate-associated osteonecrosis of the jaws.
abstract: OBJECTIVE
  To date, the therapy of bisphosphonate-associated osteonecrosis of the jaws (BONJ) has been hampered by the lack of imaging modalities that enable the extent of necrosis to be visualized. This study aims to demonstrate the feasibility of tetracycline fluorescence guided bone resection in the surgical management of BONJ.
  
  
  METHODS
  Following a 10-day preoperative administration of doxycycline in patients suffering from BONJ, sufficient doxycycline is incorporated into viable bone to be visualized with a certified medical lamp emitting exciting light at 400 to 460 nm.
  
  
  RESULTS
  Viable and necrotic bone can be discriminated intraoperatively in a routine and reproducible manner by doxycycline bone fluorescence.
  
  
  CONCLUSIONS
  In the therapy of BONJ, conservative concepts are to be favored. The fact that necrotic bone can now be selectively resected signifies an improvement of the conservative surgical therapy of BONJ.
authors.affiliation: Department of Oral and Cranio-Maxillofacial Surgery, Technische Universtität München, Munich, Germany. christoph.pautke@gmx.net
authors.forename: Christoph
authors.initials: C
authors.lastname: Pautke
authors.forename: Florian
authors.initials: F
authors.lastname: Bauer
authors.forename: Thomas
authors.initials: T
authors.lastname: Tischer
authors.forename: Kilian
authors.initials: K
authors.lastname: Kreutzer
authors.forename: Jochen
authors.initials: J
authors.lastname: Weitz
authors.forename: Marco
authors.initials: M
authors.lastname: Kesting
authors.forename: Frank
authors.initials: F
authors.lastname: Hölzle
authors.forename: Andreas
authors.initials: A
authors.lastname: Kolk
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Stürzenbaum
authors.forename: Klaus-Dietrich
authors.initials: KD
authors.lastname: Wolff
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects; D054893:Cone-Beam Computed Tomography; D004164:Diphosphonates / Q000009:adverse effects; D005240:Feasibility Studies; D005260:Female; D005453:Fluorescence; D005470:Fluorometry; D006801:Humans; D007571:Jaw Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery*; D008027:Light; D008297:Male; D019647:Oral Surgical Procedures / Q000379:methods*; D056948:Orthognathic Surgical Procedures; D010020:Osteonecrosis / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000601:surgery*; D013752:Tetracycline
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D013752:Tetracycline