[Digital ischemia following injection of a crushed tablet of zolpidem: tardive improvement with iloprost].
The intra-arterial injection of crushed tablets can lead to severe vascular disorders including necrosis. A 35-year-old patient was hospitalized after the involuntary intra-radial injection of a crushed tablet of zolpidem. As the initial treatment with heparin and vasodilators was inefficient, iloprost injections were proposed. A recovery of most lesions was obtained, but the middle finger distal phalange had to be amputated. Iloprost has already been used successfully in the treatment of lesions caused by the intra-arterial injections of drugs of abuse. It can limit ischemia and even lead to necrosis healing, thus being an alternative to conventional treatments when they are ineffective.
Boucher
Alexandra
A
Centre d'Evaluation et d'Information sur la Pharmacodépendance de Lyon, Lyon, France. alexandra.boucher@chu-lyon.fr
Assaad
Souad
S
Pariset
Caroline
C
Descotes
Jacques
J
D000328:Adult; D000671:Amputation, Surgical; D005385:Fingers / Q000098:blood supply*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D016285:Iloprost / Q000627:therapeutic use*; D007269:Injections, Intra-Arterial; D007511:Ischemia / Q000209:etiology* / Q000601:surgery; D008297:Male; D011725:Pyridines / Q000008:administration & dosage / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D015819:Substance Abuse, Intravenous; D014665:Vasodilator Agents / Q000627:therapeutic use*; D000077334:Zolpidem
D006993:Hypnotics and Sedatives; D011725:Pyridines; D014665:Vasodilator Agents; D000077334:Zolpidem; D006493:Heparin; D016285:Iloprost