title: Expression of CDllc in blood monocytes as biomarker for favorable response to antituberculosis treatment.
abstract: CD11c is involved in Mycobacterium tuberculosis phagocytosis by human macrophages. CD11c has not been evaluated during antituberculosis (anti-TB) treatment. CD11c expression was evaluated on monocytes from peripheral blood leukocytes of pulmonary TB (PTB) patients and healthy controls by flow cytometry, whereas CD11c/Arg47Trp polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism. PTB patients had increased levels of CD11c on blood monocytes as compared to healthy controls. CD11c levels decreased in response to anti-TB treatment. CD11c/Arg47Trp polymorphism is not associated with PTB.
authors.affiliation: Hospital Universitario, Monterrey, Nuevo León, Mexico.
authors.forename: Adrian G
authors.initials: AG
authors.lastname: Rosas-Taraco
authors.forename: Mario C
authors.initials: MC
authors.lastname: Salinas-Carmona
authors.forename: Agnès
authors.initials: A
authors.lastname: Revol
authors.forename: Adrian
authors.initials: A
authors.lastname: Rendon
authors.forename: Guillermo
authors.initials: G
authors.lastname: Caballero-Olin
authors.forename: Alma Y
authors.initials: AY
authors.lastname: Arce-Mendoza
mesh_terms: D000328:Adult; D000483:Alleles; D015415:Biomarkers / Q000032:analysis; D039521:CD11c Antigen / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology; D008297:Male; D009000:Monocytes / Q000378:metabolism* / Q000382:microbiology; D009169:Mycobacterium tuberculosis; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000235:genetics
chemical_list: D015415:Biomarkers; D039521:CD11c Antigen