Taurine protects immature cerebellar granullar neurons against acute alcohol administration.
Acute ethanol administration causes extensive apoptosis throughout the nervous system. We studied the protective effect of taurine on alcohol-induced apoptosis in the cerebellum of developing mice. Taurine rescued a part of immature neurons by markedly reducing caspase-3 immunoreactivity and the number of TUNEL-positive cells in most cerebellar lobules.
Taranukhin
Andrey G
AG
Brain Research Center, University of Tampere Medical School, Finland.
Taranukhina
Elena Y
EY
Djatchkova
Irina M
IM
Saransaari
Pirjo
P
Pelto-Huikko
Markku
M
Oja
Simo S
SS
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D053148:Caspase 3 / Q000378:metabolism; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D003594:Cytoplasmic Granules / Q000187:drug effects* / Q000201:enzymology; D004789:Enzyme Activation; D000431:Ethanol / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D051379:Mice; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D000431:Ethanol; D053148:Caspase 3