title: [H. pylori in development of allergic diseases in patients with gastroduodenal diseases].
abstract: OBJECTIVE
  To discover relations between allergic diseases and H. pylori infection in patients with gastroduodenal diseases.
  
  
  METHODS
  The study was made of 113 patients (age 22-65, 34 males and 79 females) with chronic gastritis and duodenal ulcer. Of them, 60 patients (group 1) had concomitant allergy (urticaria, bronchial asthma, atopic dermatitis, food allergy, pollinosis), while 53 patients (group 2) had no allergy. H. pylori infection was diagnosed with the respiratory and rapid urease test, histological and cytological tests. Enzyme immunoassay determined total antibodies (AB) to H. pylori in IgG, IgA, IgM classes; IgA-AB in the kits Vector Best (Russia), IgG-AB to H. pylori in the kits of ECOLab (Russia) and total IgE in the kits IgE-EIA (Stavropol).
  
  
  RESULTS
  In group 1 total AB to H. pylori were positive in 48 (80%), IgG-AB and IgA-AB to H. pylori in 38 (63.3%) and 43 (71.6%) patients, respectively. In elevated concentration of AgG-AB to H. pylori 46 (76.6%) patients had elevated total IgE (mean 364 IU.l). In group 2 total AB to H. pylori were detected in 45 (85.0%) patients, IgG-AB and IgA-AB to H. pylori in 47 (88.6%) and 32 (60.3%), respectively. Among patients with high level of IgG-AB to H. pylori in the serum high total IgE was only in 35.8% patients. Mean IgE was 250 IU/l.
  
  
  CONCLUSIONS
  Patients with gastroduodenal diseases associated with H. pylori and allergy and not associated had similar level of total AB to H.pylori, while higher total IgE and specific IgE-AT to H. pylori occurred in the former. Thus, H. pylori infection is associated with allergic (atopic) immune response.
authors.forename: L B
authors.initials: LB
authors.lastname: Lazebnik
authors.forename: S P
authors.initials: SP
authors.lastname: Chernutskaia
authors.forename: V B
authors.initials: VB
authors.lastname: Gervazieva
authors.forename: G V
authors.initials: GV
authors.lastname: Sukhareva
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002908:Chronic Disease; D004381:Duodenal Ulcer / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D005260:Female; D005756:Gastritis / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult