title: Neuropathological investigation of regions responsible for semantic aphasia in frontotemporal lobar degeneration.
abstract: OBJECTIVE
  Semantic dementia is a subtype of frontotemporal lobar degeneration, of which an initial symptom is semantic aphasia. Semantic dementia pathologically corresponds to atypical Pick's disease (aPiD), showing ubiq- uitin-positive inclusions similar to those in dementia with motor neuron disease (D-MND). Previous studies have not clarified the regions responsible for semantic aphasia in aPiD, and there have been no reported neuropathological studies concerning its pathomechanism.
  
  
  METHODS
  We neuropathologically investigated aPiD and D-MND cases with and without semantic aphasia.
  
  
  RESULTS
  We determined that the regions involved in the early stage of the disease course of semantic dementia were more restricted to the anterior and inferior portion of the temporal lobe on the side of the dominant hemisphere.
  
  
  CONCLUSIONS
  Degeneration of the temporal pole is most likely to participate in the pathomechanism of SA in semantic dementia.
authors.affiliation: PET/CT Dementia Research Center, Juntendo Tokyo Koto Geriatric Medical Center, Juntendo University School of Medicine, Tokyo, Japan. yamamotor@juntendo.gmc.ac.jp
authors.forename: Ryoko
authors.initials: R
authors.lastname: Yamamoto
authors.forename: Eizo
authors.initials: E
authors.lastname: Iseki
authors.forename: Shinji
authors.initials: S
authors.lastname: Higashi
authors.forename: Norio
authors.initials: N
authors.lastname: Murayama
authors.forename: Michiko
authors.initials: M
authors.lastname: Minegishi
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hino
authors.forename: Koshiro
authors.initials: K
authors.lastname: Fujisawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Kosaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Togo
authors.forename: Omi
authors.initials: O
authors.lastname: Katsuse
authors.forename: Hirotake
authors.initials: H
authors.lastname: Uchikado
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Furukawa
authors.forename: Mari
authors.initials: M
authors.lastname: Yoshida
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hashizume
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001037:Aphasia / Q000209:etiology / Q000473:pathology* / Q000523:psychology*; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000150:complications / Q000473:pathology* / Q000523:psychology*; D005260:Female; D005911:Gliosis / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000473:pathology; D020774:Pick Disease of the Brain / Q000473:pathology