title: Topical hemostasis: a valuable adjunct to control bleeding in the operating room, with a special focus on thrombin and fibrin sealants.
abstract: BACKGROUND
  Achieving surgical hemostasis plays a major role in the operating room. Occasionally, classical surgical techniques are ill suited or fail to achieve the desired control at the site of bleeding. Topical hemostasis may be seen as a useful addition to assist the surgeon in controlling surgical bleeding.
  
  
  OBJECTIVE
  To provide a brief overview of available topical hemostatic agents with a focus on the different formulations of thrombin.
  
  
  METHODS
  The scope of the review was limited to a keyword search on PubMed and Ovid (surgical hemostasis, thrombin, tissue adhesives).
  
  
  CONCLUSIONS
  Proven as adjuncts to surgical hemostasis, topical hemostatic agents have become quite valuable to bridge or to achieve permanent hemostasis.
authors.affiliation: Jefferson Medical College-Thomas Jefferson University Hospital, Division of Transplantation, Department of Surgery, 1025 Walnut Street, College Building, Suite 605, Philadelphia, PA 19107, USA. cataldo.doria@jefferson.edu
authors.forename: Cataldo
authors.initials: C
authors.lastname: Doria
authors.forename: Silvia
authors.initials: S
authors.lastname: Vaccino
mesh_terms: D016063:Blood Loss, Surgical / Q000517:prevention & control*; D005337:Fibrin / Q000008:administration & dosage*; D006487:Hemostasis; D006801:Humans; D013917:Thrombin / Q000008:administration & dosage*
chemical_list: D005337:Fibrin; D013917:Thrombin