The SWI/SNF complex and cancer.
The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).
Reisman
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Department of Internal Medicine, University of Michigan College of Medicine, Ann Arbor, MI 48109-0686, USA. dreisman@med.umich.edu
Glaros
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Thompson
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D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D002448:Cell Adhesion; D002454:Cell Differentiation; D042002:Chromatin Assembly and Disassembly; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000502:physiology*; D004265:DNA Helicases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation; D020868:Gene Silencing; D006801:Humans; D007107:Immune System / Q000502:physiology; D019656:Loss of Heterozygosity; D009369:Neoplasms / Q000235:genetics*; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D000071796:SMARCB1 Protein; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000502:physiology
D002868:Chromosomal Proteins, Non-Histone; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C102195:PBRM1 protein, human; C084011:SMARCA2 protein, human; D000071796:SMARCB1 Protein; C513266:SMARCB1 protein, human; C445179:SWI-SNF-B chromatin-remodeling complex; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D000255:Adenosine Triphosphate; C084108:SMARCA4 protein, human; D004265:DNA Helicases