MicroRNAs as novel regulators of angiogenesis.
MicroRNAs are short noncoding RNAs that function as negative regulators of gene expression. Posttranscriptional regulation by miRNAs is important for many aspects of development, homeostasis, and disease. Endothelial cells are key regulators of different aspects of vascular biology, including the formation of new blood vessels (angiogenesis). Here, we review the approaches and current experimental evidence for the involvement of miRNAs in the regulation of the angiogenic process and their potential therapeutic applications for vascular diseases associated with abnormal angiogenesis.
Suárez
Yajaira
Y
Vascular Biology and Therapuetics Program [corrected] Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06519, USA.
Sessa
William C
WC
D042501:Angiogenic Proteins / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy; D042783:Endothelial Cells / Q000378:metabolism*; D005786:Gene Expression Regulation; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism* / Q000627:therapeutic use; D009389:Neovascularization, Pathologic / Q000503:physiopathology / Q000517:prevention & control; D018919:Neovascularization, Physiologic / Q000235:genetics
D042501:Angiogenic Proteins; D035683:MicroRNAs