Morpholine containing CB2 selective agonists.
Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.
Zindell
Renée
R
Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877-0368, USA.
Riether
Doris
D
Bosanac
Todd
T
Berry
Angela
A
Gemkow
Mark J
MJ
Ebneth
Andreas
A
Löbbe
Sabine
S
Raymond
Ernest L
EL
Thome
Diane
D
Shih
Daw-Tsun
DT
Thomson
David
D
D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D007249:Inflammation; D051379:Mice; D008956:Models, Chemical; D015394:Molecular Structure; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists* / Q000737:chemistry; D013237:Stereoisomerism
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009025:Morpholines; D043885:Receptor, Cannabinoid, CB2; C037574:morpholine