title: Increased erythrocyte aggregation in men with coronary artery disease and erectile dysfunction.
abstract: We studied the association between erythrocyte aggregation (EA) and erectile dysfunction (ED) in men with coronary artery disease (CAD). Men with CAD documented by coronary angiography filled the Sexual Health Inventory for Males questionnaire to detect ED and assess its severity. EA was evaluated by filming slides of blood smear. Low percentage of slide field covered by erythrocytes represented increased EA. Overall, 133 men with CAD, mean ages 62.4+/-12.2 years, were included: 100 (75.2%) with ED and 33 (24.8%) without ED. EA was increased among men with ED compared with men without ED (percentage of slide field covered by erythrocytes 66.7+/-14.7 vs 73.1+/-14.5%; P=0.03). After adjustment for age, diabetes mellitus, hemoglobin and hematocrit levels, EA was associated with ED severity (r=0.18; P=0.038). We conclude that EA is increased in men with CAD and ED. This finding may be relevant to the pathophysiology of ED in men with CAD.
authors.affiliation: Department of Internal Medicine D, Sourasky Medical Center, Sackler School of Medicine, Tel-Aviv University, Israel. justo1@bezeqint.net
authors.forename: D
authors.initials: D
authors.lastname: Justo
authors.forename: N
authors.initials: N
authors.lastname: Mashav
authors.forename: Y
authors.initials: Y
authors.lastname: Arbel
authors.forename: M
authors.initials: M
authors.lastname: Kinori
authors.forename: A
authors.initials: A
authors.lastname: Steinvil
authors.forename: M
authors.initials: M
authors.lastname: Swartzon
authors.forename: B
authors.initials: B
authors.lastname: Molat
authors.forename: A
authors.initials: A
authors.lastname: Halkin
authors.forename: A
authors.initials: A
authors.lastname: Finkelstein
authors.forename: R
authors.initials: R
authors.lastname: Heruti
authors.forename: S
authors.initials: S
authors.lastname: Banai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D015992:Body Mass Index; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D003920:Diabetes Mellitus / Q000097:blood / Q000453:epidemiology; D007172:Erectile Dysfunction / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D004903:Erythrocyte Aggregation / Q000502:physiology*; D006306:Health Surveys; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007557:Israel / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D019529:Sexuality; D012959:Socioeconomic Factors
chemical_list: D006454:Hemoglobins