title: Inhibition of cell proliferation, vascular endothelial growth factor and tumor growth by albendazole.
abstract: Vascular endothelial growth factor (VEGF) is the key molecule mediating tumor growth and malignant ascites formation. We recently reported that, in an end stage OVCAR-3 xenograft model, albendazole (ABZ) suppresses ascites formation, but not tumor growth. Hence, in the present study, we assessed the effect of ABZ on in vitro OVCAR-3 cell proliferation plus in vivo tumor growth, however, initiating ABZ treatment at mid stage (3 weeks post cell inoculation) rather than end stage disease. Here, ABZ treatment led to potent inhibition of cell proliferation, VEGF suppression, complete inhibition of ascites formation and most strikingly arrest of tumor growth.
authors.affiliation: Cancer Research laboratories, University of New South Wales, Department of Surgery, St George Hospital (SESIAHS), Sydney, Australia.
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Pourgholami
authors.forename: Zhao Yan
authors.initials: ZY
authors.lastname: Cai
authors.forename: Lisa
authors.initials: L
authors.lastname: Wang
authors.forename: Samina
authors.initials: S
authors.lastname: Badar
authors.forename: Matthew
authors.initials: M
authors.lastname: Links
authors.forename: David Lawson
authors.initials: DL
authors.lastname: Morris
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D001201:Ascites / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D051379:Mice; D008807:Mice, Inbred BALB C; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*
chemical_list: D019394:Ki-67 Antigen; D042461:Vascular Endothelial Growth Factor A; D015766:Albendazole