title: The Child Behavior Checklist (CBCL) and the CBCL-bipolar phenotype are not useful in diagnosing pediatric bipolar disorder.
abstract: OBJECTIVE
  Previous studies have suggested that the sum of Attention, Aggression, and Anxious/Depressed subscales of Child Behavior Checklist (CBCL-PBD; pediatric bipolar disorder phenotype) may be specific to pediatric bipolar disorder (BP). The purpose of this study was to evaluate the usefulness of the CBCL and CBCL-PBD to identify BP in children <12 years old.
  
  
  METHODS
  A sample of children with BP I, II, and not otherwise specified (NOS) (n = 157) ascertained through the Course and Outcome for Bipolar Disorder in Youth (COBY) study were compared with a group of children with major depressive/anxiety disorders (MDD/ANX; n = 101), disruptive behavior disorder (DBD) (n = 127), and healthy control (HC) (n = 128). The CBCL T-scores and area under the curve (AUC) scores were calculated and compared among the above-noted groups.
  
  
  RESULTS
  Forty one percent of BP children did not have significantly elevated CBCL-PBD scores (>or=2 standard deviations [SD]). The sensitivity and specificity of CBCL-PBD >or= 2 SD for diagnosis of BP was 57% and 70-77%, respectively, and the accuracy of CBCL-PBD for identifying a BP diagnosis was moderate (AUC = 0.72-0.78).
  
  
  CONCLUSIONS
  The CBCL and the CBCL-PBD showed that BP children have more severe psychopathology than HC and children with other psychopathology, but they were not useful as a proxy for Diagnostic and Statistical Manual of Mental Disorders, 4(th) edition (DSM-IV) diagnosis of BP.
authors.affiliation: Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA. dilerrs@yahoo.com
authors.forename: Rasim Somer
authors.initials: RS
authors.lastname: Diler
authors.forename: Boris
authors.initials: B
authors.lastname: Birmaher
authors.forename: David
authors.initials: D
authors.lastname: Axelson
authors.forename: Ben
authors.initials: B
authors.lastname: Goldstein
authors.forename: MaryKay
authors.initials: M
authors.lastname: Gill
authors.forename: Michael
authors.initials: M
authors.lastname: Strober
authors.forename: David J
authors.initials: DJ
authors.lastname: Kolko
authors.forename: Tina R
authors.initials: TR
authors.lastname: Goldstein
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Hunt
authors.forename: Mei
authors.initials: M
authors.lastname: Yang
authors.forename: Neal D
authors.initials: ND
authors.lastname: Ryan
authors.forename: Satish
authors.initials: S
authors.lastname: Iyengar
authors.forename: Ronald E
authors.initials: RE
authors.lastname: Dahl
authors.forename: Lorah D
authors.initials: LD
authors.lastname: Dorn
authors.forename: Martin B
authors.initials: MB
authors.lastname: Keller
mesh_terms: D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D019540:Area Under Curve; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000453:epidemiology / Q000523:psychology; D002648:Child; D002652:Child Behavior; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007406:Interview, Psychological; D008297:Male; D010552:Personality Assessment; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D012680:Sensitivity and Specificity