title: Managing acute collapse in pregnant women.
abstract: The most important causes of acute collapse in pregnancy are pulmonary embolism, amniotic fluid embolism, acute coronary syndrome, thrombosed mechanical prosthetic heart valves, acute aortic dissection, cerebrovascular incidents and anaesthetic complications like failed intubation, anaphylaxis, and problems relating to regional or local anaesthetic agents. The management is based on supporting the different organ systems that are affected. The diagnosis of pulmonary embolism is based on a clinical suspicion supported by certain diagnostic test. Tests like D-dimers have their limitations and cannot be used alone to exclude the diagnosis especially when there is a high clinical suspicion. The choice of the best diagnostic tool is based upon weighing long-term risks to both mother and foetus on the one side and delaying the diagnosis on the other side. The management of acute coronary syndrome is based on immediate angiography and percutaneous coronary intervention. Although there are reports of the use of clopidrogel in pregnancy, there are few data on its effect on the foetus. There is no clinical evidence for fibrinolytic therapy as a reperfusion strategy in pregnancy and it is best avoided as the risk of haemorrhage outweighs the possible benefit of treatment. Patients with a prosthetic heart valve that present with a disappearance of the prosthetic heart sounds or a new murmur should get an urgent cardiac ultrasound to rule out a thrombosed prosthetic valve. Anaesthesia-related causes are an increasing cause of maternal morbidity and mortality.
authors.affiliation: Department of Obstetrics and Gynecology, University of Pretoria, Pretoria, South Africa. hennie.lombaard@up.ac.za
authors.forename: Hennie
authors.initials: H
authors.lastname: Lombaard
authors.forename: Priya
authors.initials: P
authors.lastname: Soma-Pillay
authors.forename: El-Marie
authors.initials: el-M
authors.lastname: Farrell
mesh_terms: D000773:Anesthesia, Obstetrical / Q000009:adverse effects* / Q000401:mortality; D000777:Anesthetics / Q000009:adverse effects; D000784:Aortic Dissection / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D003937:Diagnosis, Differential; D042241:Early Diagnosis; D004619:Embolism, Amniotic Fluid / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D015994:Incidence; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D018570:Risk Assessment; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D013575:Syncope / Q000209:etiology / Q000401:mortality / Q000628:therapy*
chemical_list: D000777:Anesthetics