title: Sealants after axillary lymph node dissection for breast cancer: good intentions but bad results.
abstract: BACKGROUND
  This study was conducted to evaluate the effect of 2 surgical sealants on postsurgical drainage and lymphocele formation after axillary surgery for breast cancer.
  
  
  METHODS
  This was a prospective, randomized study. Seventy-seven consecutive patients with breast cancer were included and randomized into a control group (18F vacuum drain) and 2 study groups (18F vacuum drain plus COSEAL or BioGlue).
  
  
  RESULTS
  The 3 groups were matched. Neither postsurgical drainage nor time to drain removal was affected by the use of either of the 2 sealants. Although no statistically significant difference in lymphocele formation and wound infection was noted, complications caused by intense foreign-body reaction that led to surgical intervention occurred in both study groups.
  
  
  CONCLUSIONS
  The use of surgical sealants is not recommended after axillary lymph node dissection for breast cancer. Complications of their use may lead to reoperation.
authors.affiliation: Breast Cancer Unit, Department of Surgical Oncology, University Hospital of Crete, Herakleion, Greece. taflampas2003@yahoo.gr
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Taflampas
authors.forename: Elias
authors.initials: E
authors.lastname: Sanidas
authors.forename: Manousos
authors.initials: M
authors.lastname: Christodoulakis
authors.forename: John
authors.initials: J
authors.lastname: Askoxylakis
authors.forename: John
authors.initials: J
authors.lastname: Melissas
authors.forename: Dimitrios D
authors.initials: DD
authors.lastname: Tsiftsis
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000556:secondary / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005549:Foreign-Body Reaction / Q000150:complications* / Q000601:surgery; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects* / Q000379:methods; D008207:Lymphatic Metastasis; D008210:Lymphocele / Q000139:chemically induced* / Q000601:surgery; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011446:Prospective Studies; D011506:Proteins / Q000009:adverse effects*; D012086:Reoperation; D013396:Suction / Q000379:methods; D013530:Surgical Wound Infection / Q000209:etiology* / Q000601:surgery
chemical_list: C472676:Bio-glue; C513322:CoSeal; D011506:Proteins; D011092:Polyethylene Glycols