title: Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.
abstract: BACKGROUND
  Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.
  
  
  RESULTS
  We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.
authors.affiliation: Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. bnilsson@broad.mit.edu
authors.forename: Björn
authors.initials: B
authors.lastname: Nilsson
authors.forename: Mikael
authors.initials: M
authors.lastname: Johansson
authors.forename: Fatima
authors.initials: F
authors.lastname: Al-Shahrour
authors.forename: Anne E
authors.initials: AE
authors.lastname: Carpenter
authors.forename: Benjamin L
authors.initials: BL
authors.lastname: Ebert
mesh_terms: D000465:Algorithms; D002869:Chromosome Aberrations; D019295:Computational Biology / Q000379:methods*; D018628:Gene Dosage; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide