[How safe are nanoparticles?].
Nanoparticles are experiencing an increasing application in dermatology and cosmetics. In both application areas, the requirements of nanoparticles are in most cases widely different. As a component of sunscreens, the nanoparticles are supposed to remain on the skin surface or in the upper most layers of the stratum corneum to protect the skin against UV-radiation of the sun. Whereas, on the other hand, when particulate substances are used as carrier systems for drugs, they have to cross the skin barrier to reach the target sites within the living tissue. We discuss the perspectives and risks of the topical application of nanoparticles.
Lademann
J
J
Center of Experimental and Applied Cutaneous Physiology, Klinik für Dermatologie, Venerologie und Allergologie, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin. juergen.lademann@charite.de
Meinke
M
M
Sterry
W
W
Patzelt
A
A
D000287:Administration, Topical; D003879:Dermatologic Agents / Q000009:adverse effects*; D004337:Drug Carriers / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage* / Q000009:adverse effects*; D018570:Risk Assessment; D012307:Risk Factors; D012867:Skin / Q000187:drug effects*
D003879:Dermatologic Agents; D004337:Drug Carriers