Augmentation of sebaceous lipogenesis by an ethanol extract of Grifola frondosa (Maitake mushroom) in hamsters in vivo and in vitro.
Grifola frondosa (Maitake mushroom) is an edible and medicinal mushroom with versatile effects such as antitumor and immunomodulating actions. Here, we demonstrated that an ethanol extract of G. frondosa fruiting body (Maitake extract) augmented intracellular lipid droplet formation and the production of triacylglycerols (TG), a major component of sebum, along with the activation of diacylglycerol acyltransferase, a rate-limiting enzyme of TG synthesis in cultured hamster sebocytes. The topical treatment of Maitake extract on the skin of hamster auricles augmented sebum accumulation in sebaceous glands and ducts. However, in comparison with the Maitake extract, another ethanol extract prepared from Agaricus blazei Murill showed less activity in sebaceous lipogenesis in hamsters in vivo and in vitro. These results provide novel evidence that Maitake extract augments sebaceous lipogenesis in hamsters in vivo and in vitro. Thus, Maitake extract is likely to be a unique agent leading to the remission of dry skin.
Nagao
Mie
M
Sato
Takashi
T
Akimoto
Noriko
N
Kato
Yuya
Y
Takahashi
Masao
M
Ito
Akira
A
D000818:Animals; D006224:Cricetinae; D000431:Ethanol / Q000737:chemistry; D048691:Grifola / Q000378:metabolism*; D006801:Humans; D007057:Ichthyosis; D008055:Lipids / Q000737:chemistry; D050155:Lipogenesis / Q000187:drug effects*; D010936:Plant Extracts; D012627:Sebaceous Glands / Q000166:cytology* / Q000187:drug effects*; D012871:Skin Diseases / Q000628:therapy*; D016896:Treatment Outcome; D014280:Triglycerides / Q000737:chemistry
D008055:Lipids; D010936:Plant Extracts; D014280:Triglycerides; D000431:Ethanol