Amides from the stem bark of Fagara macrophylla.
Five new amide alkaloids, N-(4-hydroxyphenethyl)octacosanamide (1), N-(4-hydroxyphenethyl)hexacosanamide (2), N-(4-hydroxyphenethyl)decanamide (3), N-vanilloyltyramine (4), and N-[O-docosanoylvanilloyl]tyramine (5), were isolated from Fagara macrophylla, together with 15 known compounds. Their structures were established by using spectroscopic techniques, chemical reactions, and comparison with previously known analogues. A cytotoxicity assay was performed with the isolates, in which compounds 4, 8, and 9 were found to possess moderate to weak activity, with IC(50) values of 30.5, 11.5, and 13.5 microg/mL, respectively.
Wansi
Jean Duplex
JD
Department of Chemistry, University of Douala, Faculty of Science, Douala, Cameroon. jdwansi@yahoo.fr
Nwozo
Sarah Onyenibe
SO
Mbaze
Luc Meva'a
LM
Devkota
Krishna Prasad
KP
Donkwe Moladje
Suzye Mireille
SM
Fomum
Zacharias Tanee
ZT
Sewald
Norbert
N
D000230:Adenocarcinoma / Q000188:drug therapy; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems; D027821:Rutaceae / Q000737:chemistry*
D000470:Alkaloids; D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts