A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells.
Inhibition of Bcl2 family proteins Bcl-X(L) and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X(L) inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported Bcl-X(L) and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis, and makes Z36 an attractive molecular tool for studying the cellular regulation of autophagic cell death and apoptosis.
Lin
Jian
J
Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, and College of Life Sciences, Peking University, Beijing, China.
Zheng
Zhibin
Z
Li
Yanjun
Y
Yu
Wenyu
W
Zhong
Wu
W
Tian
Songhai
S
Zhao
Fang
F
Ren
Xiaobai
X
Xiao
Junhai
J
Wang
Nan
N
Liu
Siyang
S
Wang
Lili
L
Sheng
Fugeng
F
Chen
Yingyu
Y
Jin
Changwen
C
Li
Song
S
Xia
Bin
B
D000225:Adenine / Q000031:analogs & derivatives / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology; D001343:Autophagy; D004305:Dose-Response Relationship, Drug; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D008968:Molecular Conformation; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D020349:Surface Plasmon Resonance; D051020:bcl-X Protein / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*
C543336:5-fluoro-1-(3'-dimethylamino)propyl-indolin-2-one; D000970:Antineoplastic Agents; D007211:Indoles; D019253:Proto-Oncogene Proteins c-bcl-2; D034741:RNA, Small Interfering; D051020:bcl-X Protein; D049452:Green Fluorescent Proteins; C025946:3-methyladenine; D000225:Adenine