title: The role of fibroblast growth factor-2 in healing the dura mater after inducing cerebrospinal fluid leakage in rats.
abstract: We conducted a study to determine the effectiveness of topically applied recombinant mouse fibroblast growth factor-2 (FGF-2) in healing the dura mater in a rat with dura mater injury and cerebrospinal fluid leakage. Laminectomies were performed in 32 rats at the level of the L2-L4 vertebrae, and a dura mater defect was created. Sixteen rats were treated postoperatively with locally applied recombinant mouse FGF-2, and 16 animals received normal saline. FGF-2 effects on dura mater healing, cerebrospinal fluid leakage, and wound healing were assessed at 3 and 6 weeks postoperatively. The extent of dura mater healing was evaluated by histological analysis. We found that dura mater healing was significantly increased (p<0.05) in rats treated with FGF-2 compared with rats in the control group. In this experimental model, locally applied FGF-2 effectively increased dura mater healing and induced no side effects.
authors.affiliation: Department of Neurosurgery, Ergani State Hospital, Ergani, Diyarbakir, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Nurata
authors.forename: Berker
authors.initials: B
authors.lastname: Cemil
authors.forename: Gökhan
authors.initials: G
authors.lastname: Kurt
authors.forename: Neşe Lortlar
authors.initials: NL
authors.lastname: Uçankuş
authors.forename: Fikret
authors.initials: F
authors.lastname: Dogulu
authors.forename: Suna
authors.initials: S
authors.lastname: Omeroğlu
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004388:Dura Mater / Q000187:drug effects* / Q000293:injuries; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D005347:Fibroblasts / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013353:Subdural Effusion / Q000473:pathology* / Q000628:therapy*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D016222:Fibroblast Growth Factor 2