title: The efficacy and safety of daptomycin vs. vancomycin for the treatment of cellulitis and erysipelas.
abstract: BACKGROUND
  Results from previous trials suggest that daptomycin may result in faster clinical improvement than penicillinase-resistant penicillins or vancomycin for patients with complicated skin and skin structure infections.
  
  
  OBJECTIVE
  The objective was to evaluate whether daptomycin treatment of cellulitis or erysipelas would result in faster resolution compared with vancomycin.
  
  
  METHODS
  The study was a prospective, evaluator-blinded, multi-centre trial. Patients were randomised to receive daptomycin 4 mg/kg once daily or vancomycin according to standard of care for 7-14 days.
  
  
  METHODS
  Adults diagnosed with cellulitis or erysipelas requiring hospitalisation and intravenous antibiotic therapy were eligible for enrolment.
  
  
  RESULTS
  The clinical success rates were 94.0% for daptomycin and 90.2% for vancomycin (95% confidence interval for the difference, -6.7%, 14.3%). There were no statistically significant differences between treatment arms in the time to resolution or improvement in any of the predefined clinical end-points. Both daptomycin and vancomycin were well tolerated.
  
  
  CONCLUSIONS
  There was no difference in the rate of resolution of cellulitis or erysipelas among patients treated with daptomycin or vancomycin. Daptomycin 4 mg/kg once daily appeared to be effective and safe for treating cellulitis or erysipelas.
authors.affiliation: Clinical Research, Cubist Pharmaceuticals, Lexington, MA 02421, USA. peter.pertel@cubist.com
authors.forename: P E
authors.initials: PE
authors.lastname: Pertel
authors.forename: B I
authors.initials: BI
authors.lastname: Eisenstein
authors.forename: A S
authors.initials: AS
authors.lastname: Link
authors.forename: B
authors.initials: B
authors.lastname: Donfrid
authors.forename: E J A
authors.initials: EJ
authors.lastname: Biermann
authors.forename: P
authors.initials: P
authors.lastname: Bernardo
authors.forename: W J
authors.initials: WJ
authors.lastname: Martone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002481:Cellulitis / Q000188:drug therapy*; D017576:Daptomycin / Q000008:administration & dosage* / Q000009:adverse effects; D004886:Erysipelas / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D017576:Daptomycin