title: The effect of active immunization on varicella-related hospitalizations in Israel.
abstract: The purpose of this study is to report on the impact of introduction of the varicella vaccine "Varilix" on hospitalizations due to varicella, following licensure in Israel in June, 2000. Data on children hospitalized throughout Israel with the diagnosis of varicella were collected from 1998 until 2003. The national rate of varicella-related hospitalizations decreased during the period 2001-2002. However in 2003 an increase in hospitalization occurred. Based on an assumption that at least 22,000 vaccinations per year were administered, we estimate that there is a greater than 60% reduction in the risk for hospitalization in the immunized population (RR = 0.32; 0.10-1.00). In summary, no national trend in reduction of hospitalization has yet been observed, but a significant reduction in hospitalization is apparent for vaccinated children.
authors.affiliation: Women and Children's Health Research Unit, The Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel. liatl@gertner.health.gov.il
authors.forename: Liat
authors.initials: L
authors.lastname: Lerner-Geva
authors.forename: Galit
authors.initials: G
authors.lastname: Hirsh-Yechezkel
authors.forename: Ilia
authors.initials: I
authors.lastname: Novikov
authors.forename: Hagit
authors.initials: H
authors.lastname: Farkash
authors.forename: Valentina
authors.initials: V
authors.lastname: Boyko
authors.forename: Zvi
authors.initials: Z
authors.lastname: Spirer
authors.forename: Justen H
authors.initials: JH
authors.lastname: Passwell
mesh_terms: D002644:Chickenpox / Q000453:epidemiology* / Q000517:prevention & control*; D019433:Chickenpox Vaccine / Q000276:immunology*; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D007557:Israel / Q000453:epidemiology; D014611:Vaccination / Q000706:statistics & numerical data*
chemical_list: D019433:Chickenpox Vaccine