title: Advanced recipient age (>60 years) alone should not be a contraindication to liver retransplantation.
abstract: Advanced age has been shown to be a risk factor for survival in primary liver transplantation. We sought to determine the independent influence of recipient age on retransplantation survival. The UNOS dataset was analyzed for adult, nonstatus 1, liver retransplantations since February 27, 2002. The univariate effect of age on 90-day and 1-year survival was analyzed. Multivariate survival models were used to determine 90-day, 1-year, and overall survival. Recipient age, donor age, model for end-stage liver disease (MELD) score, and hepatitis C status were used to construct multivariable survival models. Some 2141 liver retransplantations were analyzed. Overall, increasing recipient age was independently predictive of increasing mortality after liver retransplantation. In recipients between 18 and 60, there remained a direct relationship between age and mortality. However, in recipients aged over 60, increasing age was not independently associated with 90-day mortality (P = 0.88) and 1-year mortality (P = 0.74), despite adjusting for donor age, MELD score, and viral hepatitis status, suggesting that their original liver condition, their co-morbidities or perioperative condition plays an important role in retransplantation survival. Increasing recipient age up to 60, adversely affects liver retransplantation survival. After 60, there are no additional risks. Advanced age alone should not be an exclusionary factor when considering liver retransplantation; only the overall ability of the patient to tolerate a major surgery should be the determining factor.
authors.affiliation: Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA. tms4h@virginia.edu
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Schmitt
authors.forename: Sean C
authors.initials: SC
authors.lastname: Kumer
authors.forename: Timothy L
authors.initials: TL
authors.lastname: Pruett
authors.forename: Curtis K
authors.initials: CK
authors.lastname: Argo
authors.forename: Patrick G
authors.initials: PG
authors.lastname: Northup
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006085:Graft Survival; D006801:Humans; D008107:Liver Diseases / Q000601:surgery; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D019233:Retreatment / Q000706:statistics & numerical data