title: [Survivin and COX-2 expressions in giant cell tumor of bone and their relation to the prognosis].
abstract: OBJECTIVE
  To investigate the expression of survivin and COX-2 in giant cell tumor of bone (GCT) and explore the prognostic factors for GCT.
  
  
  METHODS
  The expressions of survivin and COX-2 in 39 GCT tissues of three Jaffe grades and 4 normal bone tissues were detected by immunohistochemical staining, and the data were analyzed in relation to the clinicopathological features of the patients.
  
  
  RESULTS
  The expressions of survivin and COX-2 were significantly higher in the GCT tissues than in normal bone tissues (P<0.01). A positive correlation was found between survivin and COX-2 expressions and the pathological grade (P<0.01), but their expressions were not correlated to the patients' gender, age or surgical approaches (P>0.05). An obviously lowered recurrence rate was observed in patients with resection of the bone segment compromised by the tumor and subsequent bone grafting. Survivin and COX-2 were not independent risk factors of the prognosis of GCT.
  
  
  CONCLUSIONS
  Survivin and COX-2 expressions may participate in the pathogenesis and development of GCT, but is not indicative of the prognosis.
authors.affiliation: Department of Emergency Medicine, First Affiliated Hospital, Medical College of Jinan University, Guangzhou 510632, China. Luosimin728@Tom.com
authors.forename: Si-min
authors.initials: SM
authors.lastname: Luo
authors.forename: Ren-de
authors.initials: RD
authors.lastname: Liu
authors.forename: Wen-rui
authors.initials: WR
authors.lastname: Li
authors.forename: Jing-hui
authors.initials: JH
authors.lastname: Hou
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000378:metabolism* / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D011379:Prognosis; D000077022:Survivin; D055815:Young Adult
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human