Cellular and molecular mechanisms of vascular lumen formation.
The formation of vascular lumens by endothelial cells is a critical step in the angiogenic process that occurs during invasion and growth of the incipient vascular sprout. Once a lumen is established, capillaries are rapidly exposed to the physical forces associated with the flow of blood which, together with genetic information, regulate the ultimate size of inner vessel diameter. Here we review the recent literature on vascular lumen formation and compare it to lumen formation in other epithelial systems. We also discuss the regulation of lumen diameter after vascular morphogenesis has been completed.
Iruela-Arispe
M Luisa
ML
Department of Molecular, Cell and Developmental Biology and Molecular Biology Institute, University of California, Los Angeles, 90095, USA. arispe@mbi.ucla.edu
Davis
George E
GE
D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D002196:Capillaries / Q000502:physiology*; D003585:Cell Biology; D004730:Endothelium, Vascular / Q000378:metabolism; D004847:Epithelial Cells / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D015398:Signal Transduction