[Regeneration of testicular tissue and restoration of rat fertility in xenotransplantation of enriched fetal cell cultures in bilateral abdominal cryptorchism].
The study of cell cultures enriched with stem and progenitor cells in the treatment of experimental hypergonadotropic hypogonadism was made on 30 white non-inbred rats with experimental cryptorchism who have undergone xenotransplantation of human fetal enriched cell cultures. Spermatogenic epithelium on histological sections was studied on day 14 and 28 after xenotransplantation with calculation of the spermatogenesis index. The fertility index was estimated for each of the groups. Transplantation of enriched cell cultures enhances efficacy of restoration of adequate germinogenic and spermatogenic testicular function, accelerates recovery of spermatogenesis and fertility with high indices of spermatogenesis and fertility but effect of the above recovery after treatment with enriched cell cultures can be seen not earlier than 72 days after transplantation.
Kamalov
A A
AA
Gukhikh
G T
GT
Kirpatovskiĭ
V I
VI
Zaraĭskiĭ
E I
EI
Poltavtseva
R A
RA
Plotnikov
E Iu
EIu
Kudriavtsev
Iu V
IuV
Efremov
E A
EA
Obokhotov
D A
DA
D000818:Animals; D002478:Cells, Cultured; D003456:Cryptorchidism / Q000628:therapy*; D005333:Fetus / Q000166:cytology*; D006801:Humans; D008297:Male; D051381:Rats; D012038:Regeneration; D013076:Sperm Count; D013737:Testis / Q000473:pathology; D013997:Time Factors; D014183:Transplantation, Heterologous