title: Determinants of adenomyosis in women who underwent hysterectomy for benign gynecological conditions: results from a prospective multicentric study in Italy.
abstract: OBJECTIVE
  We conducted a cross-sectional study on the frequency and risk factors for adenomyosis in women who underwent hysterectomy for benign gynecological conditions.
  
  
  METHODS
  All women who consecutively underwent hysterectomy during the study period for benign gynecological conditions at 18 gynecological departments were eligible for the study. A total of 820 women entered the study. Pathological data were collected prospectically.
  
  
  RESULTS
  Adenomyosis was identified in 231 women (28.2%, 95% confidence interval, CI, 24.6-32.5). The frequency of adenomyosis was similar in women with indication for surgery fibroids/menorrhagia (143 cases, 28.5%) or genital prolapse (69 cases, 28.2%). The rate ratio (RR) of adenomyosis was 1.9 (95% CI 1.2-2.8) in women reporting one or more induced abortions, in comparison with those reporting no induced abortion. Women with adenomyosis reported more frequently dysmenorrhoea and chronic pelvic pain, but not dyspareunia.
  
  
  CONCLUSIONS
  This study shows that adenomyosis is common in women who undergo hysterectomy and that it is more frequent among women reporting induced abortions dysmenorrhoea and chronic pelvic pain.
authors.affiliation: Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena, Milano, Clinica ostetrico ginecologica università di Milano, Italy. parazzini@marionegri.it
authors.forename: F
authors.initials: F
authors.lastname: Parazzini
authors.forename: V
authors.initials: V
authors.lastname: Mais
authors.forename: S
authors.initials: S
authors.lastname: Cipriani
authors.forename: M
authors.initials: M
authors.lastname: Busacca
authors.forename: P
authors.initials: P
authors.lastname: Venturini
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D004412:Dysmenorrhea / Q000150:complications; D004715:Endometriosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D007558:Italy; D007889:Leiomyoma / Q000601:surgery*; D008595:Menorrhagia / Q000601:surgery*; D008875:Middle Aged; D017699:Pelvic Pain / Q000150:complications; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D014596:Uterine Prolapse / Q000601:surgery*