title: Amides from the stem bark of Fagara macrophylla.
abstract: Five new amide alkaloids, N-(4-hydroxyphenethyl)octacosanamide (1), N-(4-hydroxyphenethyl)hexacosanamide (2), N-(4-hydroxyphenethyl)decanamide (3), N-vanilloyltyramine (4), and N-[O-docosanoylvanilloyl]tyramine (5), were isolated from Fagara macrophylla, together with 15 known compounds. Their structures were established by using spectroscopic techniques, chemical reactions, and comparison with previously known analogues. A cytotoxicity assay was performed with the isolates, in which compounds 4, 8, and 9 were found to possess moderate to weak activity, with IC(50) values of 30.5, 11.5, and 13.5 microg/mL, respectively.
authors.affiliation: Department of Chemistry, University of Douala, Faculty of Science, Douala, Cameroon. jdwansi@yahoo.fr
authors.forename: Jean Duplex
authors.initials: JD
authors.lastname: Wansi
authors.forename: Sarah Onyenibe
authors.initials: SO
authors.lastname: Nwozo
authors.forename: Luc Meva'a
authors.initials: LM
authors.lastname: Mbaze
authors.forename: Krishna Prasad
authors.initials: KP
authors.lastname: Devkota
authors.forename: Suzye Mireille
authors.initials: SM
authors.lastname: Donkwe Moladje
authors.forename: Zacharias Tanee
authors.initials: ZT
authors.lastname: Fomum
authors.forename: Norbert
authors.initials: N
authors.lastname: Sewald
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D024301:Plant Bark; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018547:Plant Stems; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D000577:Amides; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts