Site-selective azaindole arylation at the azine and azole rings via N-oxide activation.
Subjection of N-methyl 6- and 7-azaindole N-oxides to a Pd(OAc)2/DavePhos catalyst system enables regioselective direct arylation of the azine ring. Following deoxygenation, 7-azaindole substrates undergo an additional regioselective azole direct arylation event in good yield.
Huestis
Malcolm P
MP
Center for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, ON K1N 6J7, Canada.
Fagnou
Keith
K
D001372:Aza Compounds / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006574:Heterocyclic Compounds, 2-Ring / Q000138:chemical synthesis* / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure
D001372:Aza Compounds; D006574:Heterocyclic Compounds, 2-Ring; D007211:Indoles