Antimicrobial susceptibility of Streptococcus pyogenes in Central, Eastern, and Baltic European Countries, 2005 to 2006: the cefditoren surveillance program.
The in vitro activity of penicillin, ampicillin, cefditoren, cefotaxime, erythromycin, clarithromycin, and levofloxacin against 763 clinical isolates of Streptococcus pyogenes was determined. Clinically significant isolates collected from November 2005 to December 2006 in the Czech Republic, Slovakia, Hungary, Poland, Romania, Estonia, Latvia, and Lithuania (the latter 3 analyzed as Baltic countries) were studied. No resistance to beta-lactams and levofloxacin was found. The rate of erythromycin resistance in S. pyogenes varied among countries, being low (<10%) in Romania and Baltic countries, intermediate (10-20%) in Poland and Czech Republic, and high (>25%) in Hungary and Slovakia. The predominant (75.0%) erythromycin-resistant phenotype among S. pyogenes isolates was MLS(B). The identification of the prevalence of erythromycin resistance mechanism could have impact on the choice of empiric antibiotic therapy for the clinicians in such countries.
Gracia
Matilde
M
Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz, 28040 Madrid, Spain.
Díaz
Carolina
C
Coronel
Pilar
P
Gimeno
Mercedes
M
García-Rodas
Rocío
R
Rodríguez-Cerrato
Violeta
V
del Prado
Gema
G
Huelves
Lorena
L
Ruiz
Vicente
V
Naves
Plínio F L
PF
Ponte
Maria-Carmen
MC
Granizo
Juan José
JJ
Soriano
Francisco
F
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D024881:Drug Resistance, Bacterial; D005060:Europe; D005260:Female; D006801:Humans; D064704:Levofloxacin; D018942:Macrolides / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification*; D055815:Young Adult; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D018942:Macrolides; D047090:beta-Lactams; D064704:Levofloxacin; D015242:Ofloxacin