title: Metabolic profile and quality of life in class I sarcopenic overweight and obese postmenopausal women: a MONET study.
abstract: Sarcopenia is believed to be associated with disability and metabolic complications. The objective of this study was to examine the metabolic and quality-of-life profile of sarcopenic overweight and obese postmenopausal women. In this cross-sectional study of 136 healthy overweight and obese postmenopausal women, 9 class I sarcopenic women were identified. Class I sarcopenia was defined as an appendicular lean body mass index (ALBMI) <or= 6.44 kg.m(-2) (appendicular lean body mass/height). Outcome measures were body composition (dual energy X-ray absorptiometry and computed tomography), blood lipids, inflammation markers, blood pressure, insulin sensitivity (homeostasis model assessment and hyperinsulinemic-euglycemic clamp), cardiorespiratory fitness, and quality of life (Medical Outcomes Study General Health Survey questionnaire). By design, class I sarcopenic women (n = 9) had a significantly lower ALBMI and appendicular lean body mass than nonsarcopenic women (n = 127). In addition, class I sarcopenic women tended to have lower levels of insulin resistance (p = 0.070) and fasting glucose (p = 0.054). However, no difference between the groups was observed for quality of life. This study showed that, in our sample of class I sarcopenic overweight and obese postmenopausal women, subjects did not present an unfavourable metabolic or quality-of-life profile, compared with nonsarcopenic overweight and obese postmenopausal women.
authors.affiliation: Département de Nutrition, Université de Montréal, 2405, chemin Cote Ste-Catherine, Montreal, QCH3T1A8, Canada.
authors.forename: Virginie
authors.initials: V
authors.lastname: Messier
authors.forename: Antony D
authors.initials: AD
authors.lastname: Karelis
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Lavoie
authors.forename: Martin
authors.initials: M
authors.lastname: Brochu
authors.forename: May
authors.initials: M
authors.lastname: Faraj
authors.forename: Irene
authors.initials: I
authors.lastname: Strychar
authors.forename: Remi
authors.initials: R
authors.lastname: Rabasa-Lhoret
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D053580:Muscle Strength; D009133:Muscular Atrophy / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D009765:Obesity / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D050177:Overweight / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D010809:Physical Fitness; D017698:Postmenopause / Q000378:metabolism* / Q000523:psychology; D011788:Quality of Life; D011795:Surveys and Questionnaires
chemical_list: D001786:Blood Glucose; D018836:Inflammation Mediators; D007328:Insulin; D008055:Lipids