title: Positive influence of aging on the occurrence of fat replacement in the right ventricular myocardium determined by multislice-CT in subjects with atherosclerosis.
abstract: OBJECTIVE
  We evaluated predictors of fat replacement (FR) in the right-ventricular-myocardium (RVM) determined by MSCT in atherosclerotics not receiving anti-arrhythmia drugs and evaluated the relationship between the presence of FR in the RVM and the occurrence of ventricular premature beats (VPB).
  
  
  METHODS
  120-consecutive-atherosclerotics (101-males, 11-85 years) not receiving anti-arrhythmia drugs for VPB, who underwent MSCT for evaluating atherosclerosis and Holter-ECG within one-month, were retrospectively analyzed for FR in the RVM and its relationship with age, body mass index (BMI), and occurrence of VPB.
  
  
  RESULTS
  31-subjects had FR in RVM (18-males; median 67 years), and 89 did not (53-males, median 56 years). Median age was significantly higher in subjects with FR in RVM (P<0.01). The median BMI was 23.0 in subjects with FR and 23.0 in those without (not significant). Average number of VPB by Holter-ECG was 1445 in 31 subjects with FR. Without FR, the average number of VPB was 995. The difference in the numbers of VPB was not significant (P=0.73). A logistic-regression-model using age, male sex and BMI indicated that age was associated with an increased incidence of FR in the RVM (relative risk=1.055, 95% CI 1.019-1.092, P<0.05).
  
  
  CONCLUSIONS
  Age but not BMI is significantly associated with the presence of FR in the RVM. Aging might have a positive influence on the occurrence of FR in the RVM as determined by MSCT in atherosclerotics, but FR in the RVM had no influence on the occurrence of VPB.
authors.affiliation: Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Hori
authors.forename: Nobusada
authors.initials: N
authors.lastname: Funabashi
authors.forename: Masae
authors.initials: M
authors.lastname: Uehara
authors.forename: Marehiko
authors.initials: M
authors.lastname: Ueda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takaoka
authors.forename: Koki
authors.initials: K
authors.lastname: Nakamura
authors.forename: Taichi
authors.initials: T
authors.lastname: Murayama
authors.forename: Issei
authors.initials: I
authors.lastname: Komuro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology*; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D050197:Atherosclerosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002648:Child; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult