title: Ixabepilone: a new active chemotherapy in the treatment of breast cancer.
abstract: Ixabepilone (BMS247550) is a semisynthetic derivative of the natural product that optimizes the properties observed with epothilone B. This compound has some similarities with taxanes in targeting and stabilizing microtubules, but it also has major differences. Interestingly, ixabepilone was evaluated in patients with well-characterized resistance to taxanes and was able to overcome the overexpression of multidrug resistance and was unaffected by mutations in the beta-tubulin genes. The interest in ixabepilone was clinically confirmed in Phase II and III clinical studies, which have demonstrated a strong activity in patients with metastatic breast cancer resistant to taxanes and in patients suffering from other types of chemoresistant tumors.
authors.affiliation: University of Hospital Jean Minjoz, Department of Medical Oncology, Besançon, France. cvillanueva@chu-besancon.fr
authors.forename: Cristian
authors.initials: C
authors.lastname: Villanueva
authors.forename: Antoine Thiery
authors.initials: AT
authors.lastname: Vuillemin
authors.forename: Martin
authors.initials: M
authors.lastname: Demarchi
authors.forename: Fernando
authors.initials: F
authors.lastname: Bazan
authors.forename: Loïc
authors.initials: L
authors.lastname: Chaigneau
authors.forename: Xavier
authors.initials: X
authors.lastname: Pivot
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001943:Breast Neoplasms / Q000188:drug therapy*; D017322:Clinical Trials, Phase II as Topic; D017326:Clinical Trials, Phase III as Topic; D019008:Drug Resistance, Neoplasm; D034261:Epothilones / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced; D016032:Randomized Controlled Trials as Topic; D050257:Tubulin Modulators / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D034261:Epothilones; D050257:Tubulin Modulators; C430592:ixabepilone