title: Synthesis of highly deuterium-labeled (R)-K-13675, PPAR alpha agonist, for use as an internal standard for low-level quantification of drugs in plasma.
abstract: Two highly deuterium-labeled compounds, (R)-K-13675-d(11) and (R)-K-13675-d(7), were prepared for use as internal standards for low-level quantification of plasma drugs by LC/MS/MS. We successfully demonstrated their utility in pharmacokinetic studies for sensitive and precise drug quantification.
authors.affiliation: Tokyo New Drug Research Laboratories, Pharmaceutical Division, Kowa Co, Ltd, Higashimurayama, Tokyo, Japan.
authors.forename: Yukiyoshi
authors.initials: Y
authors.lastname: Yamazaki
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Ogawa
authors.forename: Kimiyuki
authors.initials: K
authors.lastname: Shibuya
mesh_terms: D000818:Animals; D001583:Benzoxazoles / Q000097:blood* / Q000737:chemistry; D002087:Butyrates / Q000097:blood* / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D002853:Chromatography, Liquid / Q000592:standards; D003903:Deuterium / Q000737:chemistry; D007553:Isotope Labeling; D047493:PPAR alpha / Q000819:agonists* / Q000378:metabolism; D051381:Rats; D012015:Reference Standards; D013237:Stereoisomerism; D053719:Tandem Mass Spectrometry / Q000592:standards
chemical_list: C540740:(R)-2-(3-((benzoxazol-2-yl-d4 (3-(4-methoxyphenoxy-d7)propyl)amino)methyl)phenoxy) butanoic acid; D001583:Benzoxazoles; D002087:Butyrates; D047493:PPAR alpha; D003903:Deuterium