Immunoprotection by polyethylene glycol in organ preservation solutions is not due to an immunomasking effect.
BACKGROUND
New organ preservation solutions that contain soluble polyethylene glycol (sPEG) molecules have been associated with reduction of acute rejection episodes.


METHODS
In the present manuscript we tested in vitro whether sPEG molecules were able to mask donor alloantigens and reduce graft immunogenicity.


RESULTS
Immunomasking effect was only evidenced when PEG molecules were covalently bound to donor cell surface.


CONCLUSIONS
We concluded that sPEG in preservation solution are unlikely to display 'immunocamouflage' property.
Perrin
Hélène
H
INSERM, U851, 21 Avenue Tony Garnier, Lyon, F-69007, France. helene.perrin@inserm.fr
Thaunat
Olivier
O
Malcus
Christophe
C
Badet
Lionel
L
Hennino
Ana
A
Codas
Ricardo
R
Touraine-Moulin
Françoise
F
Nicolas
Jean-François
JF
Morelon
Emmanuel
E
D000954:Antigens, Surface / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D009926:Organ Preservation / Q000379:methods; D019188:Organ Preservation Solutions / Q000494:pharmacology / Q000627:therapeutic use*; D016377:Organ Transplantation / Q000379:methods; D011092:Polyethylene Glycols / Q000494:pharmacology / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D000954:Antigens, Surface; D019188:Organ Preservation Solutions; D011092:Polyethylene Glycols