title: A case of ochronosis with gout and Monckeberg arteries.
abstract: Alkaptonuria is an inborn error of amino acid metabolism. A defect in tyrosine metabolism that results in accumulation of homogentisic acid in connective tissue, especially cartilage, has long been known. Degenerative arthropathy, especially of the knee and spine, develops at a relatively early age in adults. Accumulation also occurs in heart valves, and there may be a predisposition to atherosclerosis. We describe a 72-year-old man with ochronosis, gouty arthritis of both hands, and monckeberg arteries.
authors.affiliation: Rheumatology Department, Isfahan University for Medical Sciences, Alzahra Hospital, Isfahan, Iran. Karimzadeh@Med.mui.ac.ir
authors.forename: Hadi
authors.initials: H
authors.lastname: Karimzadeh
authors.forename: Negin
authors.initials: N
authors.lastname: Mohtasham
authors.forename: Mansoor
authors.initials: M
authors.lastname: Karimifar
authors.forename: Mansour
authors.initials: M
authors.lastname: Salesi
authors.forename: Zahra Sayed
authors.initials: ZS
authors.lastname: Bonakdar
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D006073:Gout / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D006074:Gout Suppressants / Q000627:therapeutic use; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D050380:Monckeberg Medial Calcific Sclerosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*; D009794:Ochronosis / Q000150:complications* / Q000175:diagnosis*; D011239:Prednisolone / Q000627:therapeutic use; D011859:Radiography
chemical_list: D000893:Anti-Inflammatory Agents; D006074:Gout Suppressants; D000493:Allopurinol; D011239:Prednisolone