[Molecular architecture of the sarcoplasmic reticulum and its role in the ECC].
The sarcoplasmic reticulum (SR) plays a fundamental role in excitation-contraction coupling, which propagates the electric signal conversion along the muscle fiber's plasmic membrane to a mechanical event manifested as a muscle contraction. It plays a crucial role in calcium homeostasis and intracellular calcium storage control (storage, liberation and uptake) necessary for fiber muscle contraction and then relaxation. These functions take place at the triad, made up of individualized SR subdomains where the protein-specific organization provides efficient and fast coupling. Ryanodine receptors (RyR) and dihydropyridine receptors (DHPR) mainly act in calcium exchanges in the SR. This particular structural and molecular architecture must be correlated to its functional specificity.
Rigoard
P
P
Service de neurochirurgie, CHU La Milétrie, 2, rue de la Milétrie, BP 577, 86021 Poitiers cedex, France. p.rigoard@chu-poitiers.fr
Buffenoir
K
K
Wager
M
M
Bauche
S
S
Giot
J-P
JP
Lapierre
F
F
D000818:Animals; D020746:Calcium Channels, L-Type / Q000502:physiology / Q000648:ultrastructure; D004594:Electrophysiology; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology* / Q000648:ultrastructure*; D019837:Ryanodine Receptor Calcium Release Channel / Q000502:physiology / Q000648:ultrastructure; D012519:Sarcoplasmic Reticulum / Q000502:physiology* / Q000648:ultrastructure*
D020746:Calcium Channels, L-Type; D019837:Ryanodine Receptor Calcium Release Channel