title: Building a new conceptual framework for receptor heteromers.
abstract: Receptor heteromers constitute a new area of research that is reshaping our thinking about biochemistry, cell biology, pharmacology and drug discovery. In this commentary, we recommend clear definitions that should facilitate both information exchange and research on this growing class of transmembrane signal transduction units and their complex properties. We also consider research questions underlying the proposed nomenclature, with recommendations for receptor heteromer identification in native tissues and their use as targets for drug development.
authors.affiliation: National Institute on Drug Abuse, IRP, NIH, DHHS, 251 Bayview Boulevard, Baltimore, Maryland 21224, USA. sferre@intra.nida.nih.gov
authors.forename: Sergi
authors.initials: S
authors.lastname: Ferré
authors.forename: Ruben
authors.initials: R
authors.lastname: Baler
authors.forename: Michel
authors.initials: M
authors.lastname: Bouvier
authors.forename: Marc G
authors.initials: MG
authors.lastname: Caron
authors.forename: Lakshmi A
authors.initials: LA
authors.lastname: Devi
authors.forename: Thierry
authors.initials: T
authors.lastname: Durroux
authors.forename: Kjell
authors.initials: K
authors.lastname: Fuxe
authors.forename: Susan R
authors.initials: SR
authors.lastname: George
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Javitch
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Lohse
authors.forename: Ken
authors.initials: K
authors.lastname: Mackie
authors.forename: Graeme
authors.initials: G
authors.lastname: Milligan
authors.forename: Kevin D G
authors.initials: KD
authors.lastname: Pfleger
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Pin
authors.forename: Nora D
authors.initials: ND
authors.lastname: Volkow
authors.forename: Maria
authors.initials: M
authors.lastname: Waldhoer
authors.forename: Amina S
authors.initials: AS
authors.lastname: Woods
authors.forename: Rafael
authors.initials: R
authors.lastname: Franco
mesh_terms: D015195:Drug Design; D011956:Receptors, Cell Surface / Q000187:drug effects* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D011956:Receptors, Cell Surface