title: Calciotropic hormones, insulin resistance, and the polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate whether abnormalities in serum concentrations of 1,25-dihydroxyvitamin D [1,25(OH)(2)D], 25-hydroxyvitamin D [25(OH)D], parathyroid hormone (PTH), calcium, and phosphorus were associated with risk of polycystic ovary syndrome (PCOS) and obesity. The possible correlations of the calciotropic hormones with insulin resistance were also examined.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Department of Genetics, Royan Institute.
  
  
  METHODS
  Eighty-five women with PCOS and 115 control women were recruited.
  
  
  METHODS
  None.
  
  
  METHODS
  Serum levels of glucose, insulin, total calcium, phosphorus, PTH, 25(OH)D, and 1,25(OH)(2)D were measured in all 200 subjects.
  
  
  RESULTS
  The presence of PCOS had age- and body mass index (BMI)-independent positive effects on serum phosphorus, PTH, 25(OH)D, and insulin concentrations as well as on insulin resistance. Furthermore, overweight/obese (BMI > or =25 kg/m(2)) women with PCOS had significantly decreased levels of 1,25(OH)(2)D and glucose compared with normal-weight (BMI <25 kg/m(2)) women with PCOS. In women with PCOS, phosphorus was correlated negatively with insulin and insulin resistance and positively with 1,25(OH)(2) D. In addition, in normal-weight patients, PTH correlated positively with insulin and insulin resistance.
  
  
  CONCLUSIONS
  It is possible that elevated levels of phosphorus and PTH in women with PCOS, at least in part, through their effects on insulin levels and insulin resistance, are involved in pathogenesis of the syndrome.
authors.affiliation: Department of Genetics, Reproductive Medicine Research Center, Royan Institute, 5 Hafez Street, BaniHashem Square, 19395-4644 Tehran, Iran. mahmouditouraj@gmail.com
authors.forename: Touraj
authors.initials: T
authors.lastname: Mahmoudi
authors.forename: Hamid
authors.initials: H
authors.lastname: Gourabi
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Ashrafi
authors.forename: Reza Salman
authors.initials: RS
authors.lastname: Yazdi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Ezabadi
mesh_terms: D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000097:blood* / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000097:blood*; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood*; D055815:Young Adult
chemical_list: D007328:Insulin; D010281:Parathyroid Hormone; D014807:Vitamin D; D010758:Phosphorus; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium