[Correlation between cardiovascular risk factors and the severity of coronary artery lesions in female patients].
OBJECTIVE
To investigate the association of the traditional and newly emerged cardiovascular risk factors with the severity of coronary artery lesion in female patients with coronary artery disease (CAD).


METHODS
This study involved 235 female in-patients undergoing coronary angiography, including 156 with confirmed coronary artery disease (CAD) and 76 non-CAD patients. Univariate and multivariate analysis of the cardiovascular risk factors and the severity of coronary artery lesion were carried out in these patients.


RESULTS
Univariate analysis showed that in the CAD patients of different severities, increased number of compromised arteries and total Gensini scores for the lesions were associated with increased incidences of the such risk factors including hypertension, type 2 diabetes, high triglycerides, high total cholesterol, low high-density lipoprotein cholesterol (HDL-C) level, high low density lipoprotein cholesterol (LDL-C) level, high uric acid level and high fibrinogen level. Multivariate regression analysis showed that high LDL-C level was the most significant independent risk factor for CAD, followed by diabetes, triglycerides, high uric acid, low HDL-C, high blood pressure and age.


CONCLUSIONS
Female CAD patients are exposed to multiple risk factors, among which high LDL-C level is the most significant independent risk factor, but the other risk factors, especially the newly emerged factor uric acid, should be given due attention in the patients.
Hu
Wei
W
Department of Cardiology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. hwhd611@163.com
Guo
Zhi-gang
ZG
Chen
Jun
J
Zhou
Zhong-jiang
ZJ
D000368:Aged; D008078:Cholesterol, LDL / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D014280:Triglycerides