title: Current concepts in the pathogenesis of early rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is a systemic inflammatory disease with a predilection for symmetrically distributed diarthroidal joints. It is clinically heterogeneous, with particular disease phenotypes defined according to a complex interplay of genes and the environment. In this chapter we first summarize current knowledge of RA genetic susceptibility, a field which has been transformed in recent years by powerful modern genotyping technologies. The importance of a recently described subclassification for the disease based upon the presence or absence of circulating autoantibodies to citrullinated peptides has further informed genetic studies, and we consider the implications for our understanding of RA pathogenesis. We then review the cellular and molecular processes that initiate and perpetuate joint destruction.
authors.affiliation: Musculoskeletal Research Group, Institute for Cellular Medicine, School of Clinical Medical Sciences, Newcastle University, Newcastle, UK. arthur.pratt@ncl.ac.uk
authors.forename: Arthur G
authors.initials: AG
authors.lastname: Pratt
authors.forename: John D
authors.initials: JD
authors.lastname: Isaacs
authors.forename: Derek L
authors.initials: DL
authors.lastname: Mattey
mesh_terms: D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics*; D042241:Early Diagnosis; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans