title: Indo Heart Survey on latent abnormal glucose regulation in patients with coronary artery disease without diabetes across India.
abstract: BACKGROUND
  The Euro Heart Survey on diabetes and heart has demonstrated high prevalence of latent glucose abnormalities in non-diabetic patients with coronary artery disease (CAD) in the European population. The aim of our survey was to assess the prevalence of latent abnormal glucose regulation in adult non-diabetic CAD patients in India.
  
  
  RESULTS
  Seven centers distributed across India recruited 350 patients. The diagnosis of CAD was done by coronary angiography showing >50% stenosis in any major epicardial coronary artery or its branches. Oral glucose tolerance test (OGTT) and fasting glucose levels were used to characterize glucose metabolism. Venous plasma glucose was measured before (fasting) and 2 hours after ingestion of glucose. Impaired fasting glucose (IFG) was defined as OGTT (0 minute)>or=100 mg/dl but <126 mg/dl and OGTT (2 hours)<140 mg/dl. Impaired glucose tolerance (IGT) was defined as OGTT (0 minute)<126 mg/dl and OGTT (2 hours)>or=140 mg/dl but <200 mg/dl. Of the 350 patients studied, 176 (50.28%) had impaired glucose regulation (IFG-28 [8%]; IGT-148[42.28%]) and 75 (21.42%) had newly detected Diabetes. In all 251 (71.7%) patients with CAD had previously undetected abnormal glucose regulation.
  
  
  CONCLUSIONS
  This survey demonstrates the presence of abnormal glucose regulation in almost three quarters of the non-diabetic Indian CAD patients. OGTT should be recommended as routine screening test for detecting latent glucose abnormalities in all CAD patients.
authors.affiliation: Spandan Heart Institute and Research Center, Nagpur, India. drmardikar@rediffmail.com
authors.forename: Manjusha
authors.initials: M
authors.lastname: Mardikar
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Deo
authors.forename: N V
authors.initials: NV
authors.lastname: Deshpande
authors.forename: U
authors.initials: U
authors.lastname: Khanolkar
authors.forename: R
authors.initials: R
authors.lastname: Mathew
authors.forename: Aziz
authors.initials: A
authors.lastname: Khan
authors.forename: A
authors.initials: A
authors.lastname: Bhagwat
authors.forename: P
authors.initials: P
authors.lastname: Sahoo
authors.forename: Neeraj
authors.initials: N
authors.lastname: Prasad
authors.forename: H M
authors.initials: HM
authors.lastname: Mardikar
mesh_terms: D000886:Anthropometry; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003906:Developing Countries; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D005951:Glucose Tolerance Test; D006306:Health Surveys; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors