Ocular pigmentation associated with clozapine.
A 55-year-old woman who was treated with long-term, high-dose clozapine for schizophrenia presented with bilateral decreased visual acuity. She had pigmentary changes affecting the cornea and the retina, as well as stellate cataract. Chlorpromazine use is known to produce similar changes, but this is the first report to our knowledge of pigmentation associated with clozapine use.
Borovik
Armand M
AM
Department of Ophthalmology, Prince of Wales Hospital, Sydney, NSW, Australia. aborovik@hotmail.com
Bosch
Martina M
MM
Watson
Stephanie L
SL
D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects*; D003318:Corneal Opacity / Q000139:chemically induced; D005128:Eye Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy*
D014150:Antipsychotic Agents; D003024:Clozapine