title: Relationship between coronary artery wall thickness measured by 64-slice multidetector computed tomography and cardiovascular risk factors.
abstract: BACKGROUND
  Recent studies have demonstrated the quantitative ability of contrast-enhanced multidetector computed tomography (MDCT) to evaluate not only the vessel lumen but also coronary plaque. The aim of this study was to assess the association between coronary wall thickness quantified by 64-slice MDCT and cardiovascular risk factors.
  
  
  RESULTS
  A total of 149 subjects with suspected coronary artery disease were scanned by contrast-enhanced 64-slice MDCT. The maximum coronary wall thickness of each proximal segment was measured and associations with baseline coronary risk factors were analyzed. The mean maximum wall thickness of all 149 patients was 0.7+/-0.3 mm and there was a significant positive correlation with age (P<0.001) and hemoglobin (Hb) A1c (P=0.001). Patients with hypertension (0.8+/-0.3 vs 0.7+/-0.3 mm, P=0.024) and diabetes (0.9+/-0.4 vs 0.7+/-0.3 mm, P=0.002) had thicker walls than those without. Multivariate linear regression analysis demonstrated that both risk factors were independently correlated with mean maximum wall thickness.
  
  
  CONCLUSIONS
  Coronary wall thickness measured by 64-slice MDCT is associated with age and HbA1c, so may add useful information to cardiovascular risk stratification.
authors.affiliation: Department of Cardiology, Juntendo University School of Medicine, Tokyo, Japan.
authors.forename: Eriko
authors.initials: E
authors.lastname: Matsunaga
authors.forename: Norihide
authors.initials: N
authors.lastname: Takaya
authors.forename: Takayuki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Akimoto
authors.forename: Katsumi
authors.initials: K
authors.lastname: Miyauchi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Daida
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000000981:diagnostic imaging*; D017023:Coronary Angiography; D003331:Coronary Vessels; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D006442:Glycated Hemoglobin; C517652:hemoglobin A1c protein, human