title: Decreased colonic transit time after transcutaneous interferential electrical stimulation in children with slow transit constipation.
abstract: OBJECTIVE
  Idiopathic slow transit constipation (STC) describes a clinical syndrome characterised by intractable constipation. It is diagnosed by demonstrating delayed colonic transit on nuclear transit studies (NTS). A possible new treatment is interferential therapy (IFT), which is a form of electrical stimulation that involves the transcutaneous application of electrical current. This study aimed to ascertain the effect of IFT on colonic transit time.
  
  
  METHODS
  Children with STC diagnosed by NTS were randomised to receive either 12 real or placebo IFT sessions for a 4-week period. After a 2-month break, they all received 12 real IFT sessions-again for a 4-week period. A NTS was repeated 6 to 8 weeks after cessation of each treatment period where able. Geometric centres (GCs) of activity were calculated for all studies at 6, 24, 30, and 48 hours. Pretreatment and posttreatment GCs were compared by statistical parametric analysis (paired t test).
  
  
  RESULTS
  Thirty-one pretreatment, 22 postreal IFT, and 8 postplacebo IFT studies were identified in 26 children (mean age, 12.7 years; 16 male). Colonic transit was significantly faster in children given real treatment when compared to their pretreatment NTS at 24 (mean CG, 2.39 vs 3.04; P < or = .0001), 30 (mean GC, 2.79 vs 3.47; P = .0039), and 48 (mean GC, 3.34 vs 4.32; P = .0001) hours. By contrast, those children who received placebo IFT had no significant change in colonic transit.
  
  
  CONCLUSIONS
  Transcutaneous electrical stimulation with interferential therapy can significantly speed up colonic transit in children with slow transit constipation.
authors.affiliation: Department of Surgical Research, Royal Children's Hospital, Melbourne, Victoria 3052, Australia.
authors.forename: Melanie C C
authors.initials: MC
authors.lastname: Clarke
authors.forename: Janet W
authors.initials: JW
authors.lastname: Chase
authors.forename: Susie
authors.initials: S
authors.lastname: Gibb
authors.forename: Val J
authors.initials: VJ
authors.lastname: Robertson
authors.forename: Anthony
authors.initials: A
authors.lastname: Catto-Smith
authors.forename: John M
authors.initials: JM
authors.lastname: Hutson
authors.forename: Bridget R
authors.initials: BR
authors.lastname: Southwell
mesh_terms: D000293:Adolescent; D002648:Child; D003248:Constipation / Q000503:physiopathology* / Q000628:therapy*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D008297:Male; D013997:Time Factors; D004561:Transcutaneous Electric Nerve Stimulation