Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein  from inactivation caused by physiological concentrations of hypochlorite.
We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 microM) and chlorogenic acid (2-10 microM) compatible with those found in humans. When human HDL was incubated in the presence of HOCl/OCl-, a concentration dependent loss of activity was apparent. Of interest, 5 caffeoylquinic acid at 5 micromol/L affords more than 60% protection of the activity reaching 100% at 25 micromol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity.
Gugliucci
Alejandro
A
Glycation, Oxidation and Disease Laboratory, Touro University-California, Vallejo, CA 94592, USA. agugliuc@touro.edu
Bastos
Deborah H Markowicz
DH
D043303:Aryldialkylphosphatase / Q000187:drug effects* / Q000378:metabolism; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003069:Coffee; D006801:Humans; D006997:Hypochlorous Acid / Q000009:adverse effects*; D030019:Ilex paraguariensis; D008075:Lipoproteins, HDL / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*
D003069:Coffee; D008075:Lipoproteins, HDL; D010936:Plant Extracts; D020011:Protective Agents; D002726:Chlorogenic Acid; D006997:Hypochlorous Acid; D043303:Aryldialkylphosphatase