The effect of bed rest on bone turnover in young women hospitalized for anorexia nervosa: a pilot study.
BACKGROUND
Malnourished adolescents with anorexia nervosa (AN) requiring medical hospitalization are at high risk for skeletal insults. Even short-term bed rest may further disrupt normal patterns of bone turnover.


OBJECTIVE
The objective of the study was to determine the effect of relative immobilization on bone turnover in adolescents hospitalized for AN.


METHODS
This was a short-term observational study.


METHODS
The study was conducted at a tertiary care pediatric hospital.


METHODS
Twenty-eight adolescents with AN, aged 13-21 yr with a mean body mass index of 15.9 +/- 1.8 kg/m(2), were enrolled prospectively on admission.


METHODS
As per standard care, all subjects were placed on bed rest and graded nutritional therapy.


METHODS
Markers of bone formation (bone specific alkaline phosphatase), turnover (osteocalcin), and bone resorption (urinary N-telopeptides NTx) were measured.


RESULTS
During the 5 d of hospitalization, serum osteocalcin increased by 0.24 +/- 0.1 ng/ml . d (P = 0.02). Urine N-telopeptides reached a nadir on d 3, declining -6.9 +/- 2.8 nm bone collagen equivalent per millimole creatinine (P = 0.01) but returned to baseline by d 5 (P > 0.05). Bone-specific alkaline phosphatase exhibited a decline that was strongly age dependent, being highly significant for younger subjects only [age 14 yr: -0.42 +/- 0.11 (P = 0.0002); age 18 yr: -0.03 +/- 0.08 (P = 0.68)]. Age had no effect on other outcome measures.


CONCLUSIONS
Limitation of physical activity during hospitalization for patients with AN is associated with suppressed bone formation and resorption and an imbalance of bone turnover. Future interventional studies involving mechanical stimulation and/or weight-bearing activity are needed to determine whether medical protocols prescribing strict bed rest are appropriate.
DiVasta
Amy D
AD
Division of Adolescent Medicine, Children's Hospital Boston, Boston, Massachusetts 02115, USA. amy.divasta@childrens.harvard.edu
Feldman
Henry A
HA
Quach
Ashley E
AE
Balestrino
Maria
M
Gordon
Catherine M
CM
D015502:Absorptiometry, Photon; D000293:Adolescent; D000469:Alkaline Phosphatase / Q000378:metabolism; D000568:Amenorrhea / Q000150:complications; D000856:Anorexia Nervosa / Q000378:metabolism* / Q000628:therapy*; D001510:Bed Rest; D015519:Bone Density / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D005260:Female; D006760:Hospitalization; D006801:Humans; D007103:Immobilization; D009752:Nutritional Status; D015675:Osteocalcin / Q000378:metabolism; D010865:Pilot Projects; D013131:Spine / Q000033:anatomy & histology / Q000378:metabolism; D015430:Weight Gain; D055815:Young Adult
D015675:Osteocalcin; D000469:Alkaline Phosphatase; D002118:Calcium