title: Swietenine: a potential oral hypoglycemic from Swietenia macrophylla seed.
abstract: Swietenine, a tetranortriterpenoid, was isolated from the Swietenia macrophylla seeds. The in vivo hypoglycemic activity was evaluated against neonatal-streptozotocin induced type 2 diabetic rats. Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats.
authors.affiliation: Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. s.dewanjee@yahoo.com
authors.forename: Saikat
authors.initials: S
authors.lastname: Dewanjee
authors.forename: Anup
authors.initials: A
authors.lastname: Maiti
authors.forename: Anup K
authors.initials: AK
authors.lastname: Das
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Mandal
authors.forename: Sankar P
authors.initials: SP
authors.lastname: Dey
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D036701:Limonins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D029582:Meliaceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
chemical_list: D007004:Hypoglycemic Agents; D036701:Limonins; D010936:Plant Extracts; C546524:swietenine