Effect of taurine on alcoholic liver disease in rats.
To investigate the effect of taurine on alcoholic liver disease in rats, male Wistar rats were administered alcohol intragastrically for 3 months. The effect of beta-alanine-mediated taurine depletion and taurine administration on the development of alcoholic liver disease was examined. It was found that taurine administration produced lower levels of aspartate aminotransferase and alkaline aminotransferase than that of the untreated group. In addition, the levels of hepatic total protein, glutathione and superoxide dismutase were higher in the taurine treated groups than in the untreated control or the taurine depleted group, while hepatic malondialdehyde content exhibited the opposite effect. Moreover, the content of hepatic hydroxyproline, serum hyaluronic acid, interleukin-2, interleukin-6, tumor necrosis factor-alpha and laminin were all decreased in the taurine treated group. The pathological changes showed that the percentage of fatty degeneration and inflammation in the taurine group were less than that of the control, taurine depleted and automatic recovery groups. These in-vivo findings demonstrate that hepatic disease caused by chronic alcohol consumption can be prevented and reversed by administration of taurine.
Wu
Gaofeng
G
College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang, China. gaofengwu@126.com
Yang
Jiancheng
J
Sun
Changmian
C
Luan
Xinhong
X
Shi
Jiao
J
Hu
Jianmin
J
D000818:Animals; D016207:Cytokines / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000517:prevention & control*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*
D016207:Cytokines; D013654:Taurine; D009569:Nitric Oxide; D052247:Nitric Oxide Synthase Type II