title: Effect of intravenous crystalloid infusion on postoperative nausea and vomiting after thyroidectomy: a prospective, randomized, controlled study.
abstract: OBJECTIVE
  Intravenous administration of compound sodium lactate (CSL) 30 ml kg to women undergoing gynaecological laparoscopy reduced the incidence of vomiting, nausea and antiemetic use when compared with 10 ml kg. The aim of this study was to evaluate the effect of intravenous fluid administration on nausea and vomiting after thyroidectomy.
  
  
  METHODS
  With ethics committee approval, 100 patients scheduled for thyroid surgery were included in this prospective, controlled, double blind study. Patients were randomized into two groups: the CSL-10 group (n = 50) received CSL 10 ml kg and the CSL-30 group received CSL 30 ml kg; the administration of fluid was completed by the end of surgery. Standardized anaesthesia was performed. The incidence of nausea and vomiting and need for antiemetics and analgesic therapy were assessed by a blinded observer at 0.5, 2, 6, 12, 18 and 24 h after surgery. Patients' satisfaction was also recorded (0-100).
  
  
  RESULTS
  The incidence of nausea (64%) was similar in both groups (P = 0.1). The incidence of vomiting was 34% in the CSL-10 group and 32% in the CSL-30 group (P = 0.83). Antiemetics (P = 0.84) and analgesic consumption (P = 0.72) did not differ significantly between the two groups. Patients' satisfaction was also comparable (P = 0.39).
  
  
  CONCLUSIONS
  Intravenous administration of CSL 30 ml kg to patients undergoing thyroidectomy did not reduce the incidence of nausea, vomiting and antiemetic use when compared with CSL 10 ml kg.
authors.affiliation: Departments of Anaesthesia and Intensive Care and Surgery, Hotel-Dieu de France Hospital, Beirut, Lebanon. chdagher@hotmail.com
authors.forename: Christine F
authors.initials: CF
authors.lastname: Dagher
authors.forename: Bassam
authors.initials: B
authors.lastname: Abboud
authors.forename: Freda
authors.initials: F
authors.lastname: Richa
authors.forename: Hicham
authors.initials: H
authors.lastname: Abouzeid
authors.forename: Claudine
authors.initials: C
authors.lastname: El-Khoury
authors.forename: Corinne
authors.initials: C
authors.lastname: Doumit
authors.forename: Cesar
authors.initials: C
authors.lastname: Yaghi
authors.forename: Patricia
authors.initials: P
authors.lastname: Yazbeck
mesh_terms: D000328:Adult; D000077324:Crystalloid Solutions; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D013965:Thyroidectomy
chemical_list: D000077324:Crystalloid Solutions; D007552:Isotonic Solutions