Triple combinations of lower and longer alkyl gallates and oxacillin improve antibiotic synergy against methicillin-resistant Staphylococcus aureus.
Using liposome systems, we found that gallates with short alkyl chains were located in the external medium and those with longer alkyl chains were located in the surface region of lipid bilayer. Combinations of these gallates remarkably reduced oxacillin MICs against methicillin-resistant Staphylococcus aureus to below the antibiotic breakpoint (< or = 2 microg/ml).
Shibata
Hirofumi
H
Department of Molecular Cell Biology and Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, 1-78 Sho-machi, Tokushima 770-8505, Japan.
Nakano
Tatsuro
T
Parvez
M Anowar Khasru
MA
Furukawa
Yoshihiro
Y
Tomoishi
Akio
A
Niimi
Shingo
S
Arakaki
Naokatu
N
Higuti
Tomihiko
T
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008081:Liposomes; D008712:Methicillin / Q000494:pharmacology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010068:Oxacillin / Q000494:pharmacology*; D011435:Propyl Gallate / Q000494:pharmacology*; D018440:beta-Lactam Resistance / Q000187:drug effects
D000900:Anti-Bacterial Agents; D008081:Liposomes; C016627:octyl gallate; D005707:Gallic Acid; D011435:Propyl Gallate; D008712:Methicillin; D010068:Oxacillin