title: 40-Hz steady state response in Alzheimer's disease and mild cognitive impairment.
abstract: The 40-Hz steady state response (SSR) reflects early sensory processing and can be measured with electroencephalography (EEG). The current study compared the 40-Hz SSR in groups consisting of mild Alzheimer's disease patients (AD) (n=15), subjects with mild cognitive impairment (MCI) (n=20) and healthy elderly control subjects (n=20). All participants were naïve for psychoactive drugs. Auditory click trains at a frequency of 40-Hz evoked the 40-Hz SSR. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment 1 week after the first. The results showed a high TRR and a significant increase of 40-Hz SSR power in the AD group compared to MCI and controls. Furthermore a moderate correlation between 40-Hz SSR power and cognitive performance as measured by ADAS-cog was shown. The results suggest that 40-Hz SSR might be an interesting candidate marker of disease progression.
authors.affiliation: Department of Psychiatry and Neuropsychology, Faculty of Health, Medicine and Life Sciences, Maastricht University, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: van Deursen
authors.forename: E F P M
authors.initials: EF
authors.lastname: Vuurman
authors.forename: V H J M
authors.initials: VH
authors.lastname: van Kranen-Mastenbroek
authors.forename: F R J
authors.initials: FR
authors.lastname: Verhey
authors.forename: W J
authors.initials: WJ
authors.lastname: Riedel
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D004576:Electromyography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D015203:Reproducibility of Results