title: Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats.
abstract: We investigated the effects of a high-fructose (HF) diet on cardiovascular risks in Sprague-Dawley rats. Twelve rats were randomly assigned to standard chow or HF diet for 20 weeks. Systolic blood pressure and circulating insulin, total cholesterol, and triacylglycerol levels were significantly higher in the HF group. Aortic sections appeared normal, but liver sections from the HF group showed lipid accretion, mild inflammation, and bile pigmentation. Liver samples from the HF group showed significantly higher total lipid levels and changes in fatty acid profile. Levels of 16:0, cis-9-18:2, cis-11-20:1, cis-13-20:1, cis-11-20:2 and 24:0 were significantly raised in the phospholipid fraction. Lower levels of cis-11-18:1, cis-9-18:2, and cis-11-20:1 and increased levels of 16:1, cis-9-18:1, and cis-13-20:1 were found in the non-esterified fatty acid fraction. HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats.
authors.affiliation: Departments of Human Nutritional Sciences, The University of Manitoba and St. Boniface General Hospital Research Centre, Winnipeg, MB, Canada.
authors.forename: Mohammad M
authors.initials: MM
authors.lastname: Abdullah
authors.forename: Natalie N
authors.initials: NN
authors.lastname: Riediger
authors.forename: Qilin
authors.initials: Q
authors.lastname: Chen
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhao
authors.forename: Nazila
authors.initials: N
authors.lastname: Azordegan
authors.forename: Zuyuan
authors.initials: Z
authors.lastname: Xu
authors.forename: Gabor
authors.initials: G
authors.lastname: Fischer
authors.forename: Rgia A
authors.initials: RA
authors.lastname: Othman
authors.forename: Grant N
authors.initials: GN
authors.lastname: Pierce
authors.forename: Paramjit S
authors.initials: PS
authors.lastname: Tappia
authors.forename: Jitao
authors.initials: J
authors.lastname: Zou
authors.forename: Mohammed H
authors.initials: MH
authors.lastname: Moghadasian
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology; D016207:Cytokines / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000494:pharmacology; D004435:Eating; D005632:Fructose / Q000008:administration & dosage* / Q000494:pharmacology; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D016207:Cytokines; D004040:Dietary Carbohydrates; D007328:Insulin; D008055:Lipids; D005632:Fructose