Unrelated stem cell transplant for infantile idiopathic myelofibrosis.
Idiopathic myelofibrosis (IMF) is a rare disease in children that can present during infancy and have a protracted course. The only known curative approach for this disease in adult patients is allogeneic stem cell transplant. We present two cases of IMF during infancy that did not resolve with supportive care measures. Both patients underwent unrelated stem cell transplant with complete resolution of their hematologic manifestations and resolution of the bone marrow fibrosis.
Domm
Jennifer
J
Pediatric Hematology/Oncology, Vanderbilt University, Nashville, Tennessee 37232-6310, USA. jennifer.domm@vanderbilt.edu
Calder
Cassie
C
Manes
Becky
B
Crossno
Christine
C
Correa
Hernan
H
Frangoul
Haydar
H
D006801:Humans; D007223:Infant; D008297:Male; D055728:Primary Myelofibrosis / Q000473:pathology / Q000628:therapy*; D033581:Stem Cell Transplantation