title: Who and where is the renal baroreceptor?: the connexin hypothesis.
abstract: Gap junctions are emerging as a fundamental mechanism for the control of renin synthesis and release. Connexin40 is prominent in juxtaglomerular cells. When missing, it results in hyperreninemia and hypertension. Schweda et al. offer exciting data demonstrating that connexin45, a connexin with different biophysical properties, can replace connexin40 functions related to the control of renin.
authors.affiliation: Department of Pediatrics, University of Virginia Medical Center, Charlottesville, Virginia 22908, USA. rg@virginia.edu
authors.forename: R Ariel
authors.initials: RA
authors.lastname: Gomez
authors.forename: Maria Luisa S
authors.initials: ML
authors.lastname: Sequeira Lopez
mesh_terms: D000818:Animals; D017630:Connexins / Q000502:physiology*; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000502:physiology; D051379:Mice; D012083:Renin / Q000378:metabolism*; D012084:Renin-Angiotensin System; D000097003:Gap Junction alpha-5 Protein
chemical_list: D017630:Connexins; D012083:Renin; D000097003:Gap Junction alpha-5 Protein; C082920:connexin 45