[Lipoproteins and their receptors in the central nervous system].
Central nervous system(CNS) has nearly a quarter of total body cholesterol, although its weight is only 2% of the whole body. In the adult brain, cholesterol synthesis is extremely low, and a half life of cholesterol is about 5 years. In the cerebrospinal fluid(CSF), the only lipoprotein is high-density lipoprotein (HDL). CSF-HDL is larger than plasma HDL, and rich in apolipoprotein E (apoE). In CNS, neurons and glia cells express several lipoprotein receptors and ATP-binding cassette (ABC) transporters. These lipoprotein receptors can bind to and take up CSF-HDL for cholesterol recycling. Recent research has focused on investigating the role of CSF-HDL and lipoprotein receptors in the pathogenesis of Alzheimer disease.
Miida
Takashi
T
Department of Clinical Laboratory Medicine, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421, Japan. tmiida@juntendo.ac.jp
Hirayama
Satoshi
S
D002490:Central Nervous System / Q000737:chemistry; D008074:Lipoproteins / Q000134:cerebrospinal fluid*; D018110:Receptors, Lipoprotein / Q000032:analysis*
D008074:Lipoproteins; D018110:Receptors, Lipoprotein