The role of glucocorticoids for spiral ganglion neuron survival.
Glucocorticoids, which are steroidal stress hormones, have a broad array of biological functions. Synthetic glucocorticoids are frequently used therapeutically for many pathologic conditions, including diseases of the inner ear; however, their exact functions in the cochlea are not completely understood. Recent work has clearly demonstrated the presence of glucocorticoid signaling pathways in the cochlea and elucidated their protective roles against noise-induced hearing loss. Furthermore, indirect evidence suggests the involvement of glucocorticoids in age-related loss of spiral ganglion neurons and extensive studies in the central nervous system demonstrate profound effects of glucocorticoids on neuronal functions. With the advancement of recent pharmacologic and genetic tools, the role of these pathways in the survival of spiral ganglion neurons after noise exposure and during aging should be revealed.
Jin
David Xu
DX
Department of Otolaryngology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Lin
Zhaoyu
Z
Lei
Debin
D
Bao
Jianxin
J
D000818:Animals; D002470:Cell Survival / Q000502:physiology; D003051:Cochlea / Q000378:metabolism; D005938:Glucocorticoids / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013136:Spiral Ganglion / Q000166:cytology* / Q000378:metabolism*
D005938:Glucocorticoids