[The role of alimentary magnesium deficiency in development of nephrolithiasis and its correction with magnesium salts in rats].
Aims of our work were to appraise the quantity and nature of renal calcifications and mineral metabolism in the magnesium-deficient rats; and to find out whether the combination of pyridoxine with Mg L-aspartate or Mg chloride will reduce the length of the treatment needed to recover rats from magnesium deficient condition and urolithiasis state. To induce hypomagnesemia, fifty rats were placed on a magnesium-deficient diet (magnesium content < or = 15 mg/kg) and demineralized water for 10 weeks. On the forty-ninth day of magnesium-deficient diet, rats were treated one of the six supplementations: MgCl2, Mg-L-Asp or their combinations with pyridoxine hydrochloride, magnesium sulfate, magne B6.
Spasov
A A
AA
Iezhitsa
I N
IN
Kharitonova
M V
MV
Kravchenko
M S
MS
Snigur
G L
GL
D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D019344:Lactic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D017616:Magnesium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D008275:Magnesium Deficiency / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D008297:Male; D053040:Nephrolithiasis / Q000097:blood / Q000188:drug therapy* / Q000209:etiology*; D051381:Rats; D016896:Treatment Outcome; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000627:therapeutic use
D017616:Magnesium Compounds; D001224:Aspartic Acid; D019344:Lactic Acid; D025101:Vitamin B 6