Antiviral immunity in drosophila.
Genetic analysis of the drosophila antiviral response indicates that RNA interference plays a major role. This contrasts with the situation in mammals, where interferon-induced responses mediate innate antiviral host-defense. An inducible response also contributes to antiviral immunity in drosophila, and similarities in the sensing and signaling of viral infection are becoming apparent between drosophila and mammals. In particular, DExD/H box helicases appear to play a crucial role in the cytosolic detection of viral RNAs in flies and mammals.
Kemp
Cordula
C
CNRS-UPR, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Imler
Jean-Luc
JL
D000818:Animals; D060565:Argonaute Proteins; D020169:Caspases; D053487:DEAD-box RNA Helicases; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000276:immunology / Q000821:virology; D019143:Evolution, Molecular; D005786:Gene Expression Regulation / Q000276:immunology; D054884:Host-Pathogen Interactions; D008565:Membrane Proteins; D009687:Nuclear Proteins; D020365:RNA Helicases; D034622:RNA Interference; D012327:RNA Virus Infections / Q000235:genetics / Q000276:immunology*; D012328:RNA Viruses / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity; D012367:RNA, Viral; D034743:RNA-Induced Silencing Complex; D043244:Ribonuclease III; D014774:Virulence
C433807:AGO2 protein, Drosophila; D060565:Argonaute Proteins; D029721:Drosophila Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D012367:RNA, Viral; D034743:RNA-Induced Silencing Complex; C425767:vir protein, Drosophila; C478069:DCR-2 protein, Drosophila; D043244:Ribonuclease III; D020169:Caspases; C431941:DAMM protein, Drosophila; D053487:DEAD-box RNA Helicases; D020365:RNA Helicases