title: Fundamental equation of the dual flow rate-solvent gradient elution in liquid chromatography.
abstract: An alternative expression of the fundamental equation of multi-mode gradient elution involving simultaneous changes in mobile phase composition and flow rate is derived using simple kinetic arguments and graphic interpretation. The new expression consists of a system of two integral equations and provides an easy and direct way of predicting retention times under dual-mode gradient conditions.
authors.affiliation: Department of Chemistry, Laboratory of Physical Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece. kpapachr@chem.auth.gr
authors.forename: Kostas
authors.initials: K
authors.lastname: Papachristos
authors.forename: Panos
authors.initials: P
authors.lastname: Nikitas
mesh_terms: D000465:Algorithms; D002853:Chromatography, Liquid / Q000379:methods*; D008956:Models, Chemical; D012997:Solvents / Q000737:chemistry*
chemical_list: D012997:Solvents