title: Metal imaging on surface of micro- and nanoelectronic devices by laser ablation inductively coupled plasma mass spectrometry and possibility to measure at nanometer range.
abstract: An analytical mass spectrometric method for the elemental analysis of nano-bioelectronic devices involved in bioengineering research was developed and applied for measurements of selected metals (Au, Ti, Pt, Cr, etc.) on interdigitated electrode array chips (IDA-chip). An imaging laser ablation inductively coupled plasma mass spectrometric (LA-ICP-MS) procedure was used to map the elements of interest on the surface of the analyzed sample. The obtained images of metals were in a good agreement and corresponded to the micro- and nanofabricated metal electrode pattern. For the analysis at nanometer resolution scale a NF-LA-ICP-MS (NF-near-field) procedure was applied, which utilize thin Ag needle to enhance laser beam energy and improve spatial resolution of the method. The results show a approximately 100x enhancement of analyte signal, when the needle was positioned in the "near-field region" to the sample surface and the laser shot was performed. In addition, mass spectrometric studies of reproducibly for five separated NF-LA shots in different places of analyzed sample yielded an RSD of the measurement of 16%.
authors.affiliation: Central Division of Analytical Chemistry, Research Centre Juelich, Juelich, Germany. m.zoriy@fz-juelich.de
authors.forename: Myroslav V
authors.initials: MV
authors.lastname: Zoriy
authors.forename: Dirk
authors.initials: D
authors.lastname: Mayer
authors.forename: J Sabine
authors.initials: JS
authors.lastname: Becker
mesh_terms: D004867:Equipment Design; D056656:Lab-On-A-Chip Devices; D007834:Lasers; D013058:Mass Spectrometry / Q000379:methods*; D019216:Metals, Heavy / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D015203:Reproducibility of Results; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D019216:Metals, Heavy; D014025:Titanium