title: Intrathoracic injection of paclitaxel for a patient with stage IV serous ovarian cancer: a case report.
abstract: BACKGROUND
  There have so far only been few reports on the intrathoracic injection (IT) of paclitaxel for ovarian cancer.
  
  
  METHODS
  The patient was treated with IT paclitaxel to control a large volume of pleural effusion as neoadjuvant chemotherapy. A total of 220 mg (110 mg in each thoracic cavity) of paclitaxel was administrated and the pleural effusion dramatically decreased. The intrathoracic concentration of paclitaxel was 1,524.0, 107.5, 8.1, 11.0 and 3.8 microm/l at 0, 24, 48, 72 and 96 h, respectively. The plasma concentration was 0.05, 0.11, 0.07, 0.04 and 0.02 microm/l, respectively.
  
  
  CONCLUSIONS
  An extremely high concentration was maintained over 96 h and there was slight transition into general circulation following IT administration. IT paclitaxel might be effective in some patients with ovarian serous adenocarcinoma who have a refractory tumor in the thoracic cavity.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. pikarun2620@jcom.home.ne.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Mitamura
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Hosaka
authors.forename: Mahito
authors.initials: M
authors.lastname: Takeda
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Watari
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sakuragi
mesh_terms: D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D017024:Chemotherapy, Adjuvant / Q000379:methods; D018284:Cystadenocarcinoma, Serous / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007267:Injections; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016066:Pleural Effusion, Malignant / Q000188:drug therapy; D013909:Thorax; D013997:Time Factors
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel