title: Antimicrobial susceptibility of Streptococcus pyogenes in Central, Eastern, and Baltic European Countries, 2005 to 2006: the cefditoren surveillance program.
abstract: The in vitro activity of penicillin, ampicillin, cefditoren, cefotaxime, erythromycin, clarithromycin, and levofloxacin against 763 clinical isolates of Streptococcus pyogenes was determined. Clinically significant isolates collected from November 2005 to December 2006 in the Czech Republic, Slovakia, Hungary, Poland, Romania, Estonia, Latvia, and Lithuania (the latter 3 analyzed as Baltic countries) were studied. No resistance to beta-lactams and levofloxacin was found. The rate of erythromycin resistance in S. pyogenes varied among countries, being low (<10%) in Romania and Baltic countries, intermediate (10-20%) in Poland and Czech Republic, and high (>25%) in Hungary and Slovakia. The predominant (75.0%) erythromycin-resistant phenotype among S. pyogenes isolates was MLS(B). The identification of the prevalence of erythromycin resistance mechanism could have impact on the choice of empiric antibiotic therapy for the clinicians in such countries.
authors.affiliation: Department of Medical Microbiology and Antimicrobial Chemotherapy, Fundación Jiménez Díaz, 28040 Madrid, Spain.
authors.forename: Matilde
authors.initials: M
authors.lastname: Gracia
authors.forename: Carolina
authors.initials: C
authors.lastname: Díaz
authors.forename: Pilar
authors.initials: P
authors.lastname: Coronel
authors.forename: Mercedes
authors.initials: M
authors.lastname: Gimeno
authors.forename: Rocío
authors.initials: R
authors.lastname: García-Rodas
authors.forename: Violeta
authors.initials: V
authors.lastname: Rodríguez-Cerrato
authors.forename: Gema
authors.initials: G
authors.lastname: del Prado
authors.forename: Lorena
authors.initials: L
authors.lastname: Huelves
authors.forename: Vicente
authors.initials: V
authors.lastname: Ruiz
authors.forename: Plínio F L
authors.initials: PF
authors.lastname: Naves
authors.forename: Maria-Carmen
authors.initials: MC
authors.lastname: Ponte
authors.forename: Juan José
authors.initials: JJ
authors.lastname: Granizo
authors.forename: Francisco
authors.initials: F
authors.lastname: Soriano
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D024881:Drug Resistance, Bacterial; D005060:Europe; D005260:Female; D006801:Humans; D064704:Levofloxacin; D018942:Macrolides / Q000494:pharmacology; D008297:Male; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology; D013290:Streptococcal Infections / Q000382:microbiology*; D013297:Streptococcus pyogenes / Q000187:drug effects* / Q000302:isolation & purification*; D055815:Young Adult; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D047090:beta-Lactams; D064704:Levofloxacin; D015242:Ofloxacin