A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin alpha(v)beta(3).
A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.
Xiong
Liqin
L
Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China.
Yu
Mengxiao
M
Cheng
Mingjun
M
Zhang
Meng
M
Zhang
Xiaoyan
X
Xu
Congjian
C
Li
Fuyou
F
D000165:Acridine Orange; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000378:metabolism*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D008027:Light; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000378:metabolism*; D038761:Photobleaching; D013056:Spectrophotometry, Ultraviolet
D005456:Fluorescent Dyes; D039302:Integrin alphaVbeta3; D000165:Acridine Orange