title: An interference localized surface plasmon resonance biosensor based on the photonic structure of Au nanoparticles and SiO2/Si multilayers.
abstract: This paper presents the experimental and simulation analysis of an original nanostructure design constructed with plasmonic gold nanoparticles and photonic thin-film multilayers of silicon dioxide (500 nm in thickness) and silicon on a substrate. Our nanostructure substrate showed a high sensitivity for various refractive index RI solutions and a prominent capacity for functionalizing alkanethiol molecules on the gold surface and demonstrates great potential in the development of a microfluidic-based biosensor for monitoring biotin-avidin interactions in real-time.
authors.affiliation: School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1, Asahidai, Nomi, Ishikawa 923-1292, Japan.
authors.forename: Ha Minh
authors.initials: HM
authors.lastname: Hiep
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yoshikawa
authors.forename: Masato
authors.initials: M
authors.lastname: Saito
authors.forename: Eiichi
authors.initials: E
authors.lastname: Tamiya
mesh_terms: D000388:Air; D001360:Avidin / Q000032:analysis / Q000378:metabolism; D001710:Biotin / Q000032:analysis / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques; D009821:Oils / Q000737:chemistry; D017785:Photons; D012825:Silicon / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D020349:Surface Plasmon Resonance / Q000379:methods*; D013499:Surface Properties
chemical_list: D009821:Oils; D001360:Avidin; D001710:Biotin; D006046:Gold; D012822:Silicon Dioxide; D012825:Silicon