Effects of Hedysari polysaccharides on regeneration and function recovery following peripheral nerve injury in rats.
It has been demonstrated that aqueous extract of Radix Hedysari Prescription and modified Radix Hedysari Prescription could improve the regeneration of injured peripheral nerve. Radix Hedysari is a main component in these two formulas. We hypothesized that Hedysari polysaccharides (HPS), a main active ingredient, could also enhance peripheral nerve regeneration after nerve injury in adult animals. In the present study, we examined the effects of HPS on sciatic nerve regeneration for 6 weeks following clamping in rats (administrated orally of 2 ml HPS liquid daily, 0.25 g/ml). The results showed that HPS was able to enhance sciatic function index (SFI) value, tibial function index (TFI) value, peroneal nerve function index (PFI) value, conduction velocity, and the number of regenerated myelinated nerve fibers, suggesting the potential clinical application of HPS for the treatment of peripheral nerve injury in humans.
Wei
Shao-Yin
SY
Department of Orthopaedics and Trauma, Peking University People's Hospital, Beijing 100044, China.
Zhang
Pei-Xun
PX
Han
Na
N
Dang
Yu
Y
Zhang
Hong-Bo
HB
Zhang
Dian-Ying
DY
Fu
Zhong-Guo
ZG
Jiang
Bao-Guo
BG
D000818:Animals; D007887:Fabaceae; D008297:Male; D009046:Motor Neurons / Q000187:drug effects; D009416:Nerve Regeneration / Q000187:drug effects*; D010543:Peroneal Nerve / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D011134:Polysaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000187:drug effects; D012584:Sciatic Nerve / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D020426:Sciatic Neuropathy / Q000188:drug therapy*; D013979:Tibial Nerve / Q000187:drug effects
D010936:Plant Extracts; D011134:Polysaccharides