Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI).
Acute renal failure (ARF) results from ischemic or toxic renal injury and is a common disorder with an overall mortality rate of about 50%. Despite the advent of dialysis and increasing knowledge regarding the causes and the effects of ARF, this trend has hardly changed for several decades. Cisplatin is a broadly used anticancer drug and is widely known to induce acute renal failure as a result of renal tubular injury. In this study, we have demonstrated that: (1) TauT is down-regulated by the p53 tumor suppressor gene in renal proximal tubule LLC-PK1 cells; (2) cisplatin down-regulates the expression of TauT in renal proximal tubule cells through, at least in part, a p53-dependent pathway; and (3) forced overexpression of TauT can attenuate cisplatin-induced apoptosis of renal proximal tubule cells.
Han
Xiaobin
X
Department of Pediatrics, University of Tennessee Health Science Center, Memphis, TN, USA. xhan@utmem.edu
Chesney
Russell W
RW
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D001483:Base Sequence; D015153:Blotting, Western; D002945:Cisplatin / Q000633:toxicity*; D017931:DNA Primers; D016158:Genes, p53; D018374:LLC-PK1 Cells; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D026901:Membrane Transport Proteins / Q000235:genetics / Q000502:physiology*; D013552:Swine; D000099247:Taurine Transporters
D000970:Antineoplastic Agents; D002945:Cisplatin; D017931:DNA Primers; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D000099247:Taurine Transporters