Microbial transformation of dehydroandrographolide by Cunninghamella elegans.
The biotransformation of dehydroandrographolide (1) by Cunninghamella elegans was performed and four transformed products were obtained. Based on their extensive spectral data, the structures of these metabolites were identified as 3-oxo-dehydroandrographolide (2), 3-oxo-2beta-hydroxy-dehydroandrographolide (3), 3-oxo-8beta,17alpha-epoxydehydroandrographolide (4), 3,19-dihydroxy-7,11,13-ent-labdatrien-15,16-olide (5), respectively. Among them, products 3-5 are new compounds.
Xin
Xiu-Lan
XL
Key Laboratory of Bioprocess of Beijing, Beijing University of Chemical Technology, Beijing, China.
Ma
Xiao-Chi
XC
Zhang
Bao-Jing
BJ
Su
Dong-Hai
DH
Wu
Zhi-Ming
ZM
Wang
Xiao-Jie
XJ
Li
Xiao-Yan
XY
Yuan
Qi-Peng
QP
D000818:Animals; D001711:Biotransformation; D017173:Caenorhabditis elegans / Q000378:metabolism; D020093:Cunninghamella / Q000378:metabolism*; D004224:Diterpenes / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000378:metabolism; D012233:Rhizopus / Q000378:metabolism
D004224:Diterpenes; C478098:dehydroandrographolide