title: On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.
authors.affiliation: Antibiotics Laboratory and Chemical Biology Department, RIKEN, Wako, Saitama 351-0198, Japan.
authors.forename: Isao
authors.initials: I
authors.lastname: Miyazaki
authors.forename: Siro
authors.initials: S
authors.lastname: Simizu
authors.forename: Keisuke
authors.initials: K
authors.lastname: Ishida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D002460:Cell Line; D055808:Drug Discovery; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D016559:Tacrolimus / Q000737:chemistry / Q000378:metabolism; D022061:Tacrolimus Binding Protein 1A / Q000235:genetics / Q000378:metabolism
chemical_list: D007166:Immunosuppressive Agents; D008024:Ligands; D010446:Peptide Fragments; D011506:Proteins; D022061:Tacrolimus Binding Protein 1A; D016559:Tacrolimus