Knitting and untying the protein network: modulation of protein ensembles as a therapeutic strategy.
Proteins constitute the working machinery and structural support of all organisms. In performing a given function, they must adopt highly specific structures that can change with their level of activity, often through the direct or indirect action of other proteins. Indeed, proteins typically function within an ensemble, rather than individually. Hence, they must be sufficiently flexible to interact with each other and execute diverse tasks. The discovery that errors within these groups can ultimately cause disease has led to a paradigm shift in drug discovery, from an emphasis on single protein targets to a holistic approach whereby entire ensembles are targeted.
Gordo
Susana
S
Institute for Research in Biomedicine, Parc Científic de Barcelona, Barcelona, Spain.
Giralt
Ernest
E
D055808:Drug Discovery / Q000379:methods*; D006801:Humans; D008659:Metabolic Diseases / Q000188:drug therapy; D053858:Metabolic Networks and Pathways / Q000235:genetics; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D054730:Protein Interaction Domains and Motifs / Q000235:genetics*; D025941:Protein Interaction Mapping; D011506:Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry / Q000235:genetics
D011506:Proteins; D016159:Tumor Suppressor Protein p53