title: Poor survival outcomes in HER2-positive breast cancer patients with low-grade, node-negative tumours.
abstract: We present a retrospective analysis on a cohort of low-grade, node-negative patients showing that human epidermal growth factor receptor 2 (HER2) status significantly affects the survival in this otherwise very good prognostic group. Our results provide support for the use of adjuvant trastuzumab in patients who are typically classified as having very good prognosis, not routinely offered standard chemotherapy, and who as such do not fit current UK prescribing guidelines for trastuzumab.
authors.affiliation: Glasgow Royal Infirmary, Section of Surgery, Division of Cancer Sciences and Molecular Pathology, Faculty of Medicine, UK. smtovey@doctors.org.uk
authors.forename: S M
authors.initials: SM
authors.lastname: Tovey
authors.forename: S
authors.initials: S
authors.lastname: Brown
authors.forename: J C
authors.initials: JC
authors.lastname: Doughty
authors.forename: E A
authors.initials: EA
authors.lastname: Mallon
authors.forename: T G
authors.initials: TG
authors.lastname: Cooke
authors.forename: J
authors.initials: J
authors.lastname: Edwards
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis* / Q000235:genetics / Q000401:mortality / Q000473:pathology; D005260:Female; D018734:Genes, erbB-2 / Q000502:physiology; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis