title: Estrogen and progesterone receptors in smooth muscle component of deep infiltrating endometriosis.
abstract: OBJECTIVE
  To analyze the expression of estrogen (ER) and progesterone (PR) receptors in the smooth muscle component (SMC) of deep infiltrating endometriosis (DIE).
  
  
  METHODS
  A prospective clinical and pathologic study of 60 cases of DIE.
  
  
  METHODS
  University Hospital Department of Gynacology.
  
  
  METHODS
  Sixty patients with symptomatic DIE (uterosacral endometriosis n = 14; bladder endometriosis n = 10; colonic endometriosis n = 16; rectovaginal endometriosis n = 20).
  
  
  METHODS
  Laparoscopic surgery.
  
  
  METHODS
  The expression of ER and PR was studied by immunohistochemistry in the SMC directly around endometriotic foci and at distance (at least >1.5 cm) from them in correlation with proliferative and secretory phases of cycle.
  
  
  RESULTS
  The ER and PR were present in the SMC of DEI in each location excepting colonic endometriosis where ER were absent. Independently of cycle's phases the PR were more abundant than ER. With the exception of rectovaginal endometriosis, where the ER and PR were more abundant in the proliferative than in the secretory phase, in other locations the ER and PR did not differ significantly with cycle's phases. Last, if ER and PR were more abundant in SMC around endometriotic foci than at a distance from them. However, the difference was not significant.
  
  
  CONCLUSIONS
  Our data substantially confirm for the first time that in various forms of DIE, ER and PR are present not only in glands and stroma but also in the smooth muscle major histologic component of this disease.
authors.affiliation: Department of Pathology, Erasme University Hospital, Free University of Brussels, Brussels, Belgium. Jean-Christophe.Noel@erasme.ulb.ac.be
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Noël
authors.forename: Charles
authors.initials: C
authors.lastname: Chapron
authors.forename: Dario
authors.initials: D
authors.lastname: Bucella
authors.forename: Frederic
authors.initials: F
authors.lastname: Buxant
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Peny
authors.forename: Isabelle
authors.initials: I
authors.lastname: Fayt
authors.forename: Bruno
authors.initials: B
authors.lastname: Borghese
authors.forename: Vincent
authors.initials: V
authors.lastname: Anaf
mesh_terms: D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005498:Follicular Phase / Q000378:metabolism; D006801:Humans; D007410:Intestinal Diseases / Q000378:metabolism* / Q000473:pathology; D008183:Luteal Phase / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism* / Q000473:pathology; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology; D001745:Urinary Bladder Diseases / Q000378:metabolism* / Q000473:pathology
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone