[Effect of endothelin-1 on the liver oxygen balance and heat production].
In acute experiments on anesthetized rats was shown, that endothelin-1 constricts arterial and portal vessels of the liver, reduces blood flow in the liver, supresses tissue respiration and heat production in this organ. Thus, the level of oxygen pressure in the liver might grow. The influence endothelin-1 on tissue respiration and heat production is mediated through ET(A)-receptors.
Ianchuk
P I
PI
Rusinchuk
Ia I
IaI
Tieriekhov
A A
AA
D000818:Animals; D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1 / Q000494:pharmacology*; D005260:Female; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008102:Liver Circulation / Q000187:drug effects; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D022722:Thermogenesis / Q000187:drug effects*
D065128:Endothelin Receptor Antagonists; D019332:Endothelin-1; D010456:Peptides, Cyclic; C072247:cyclo(Trp-Asp-Pro-Val-Leu)