title: [Serum anti-Pg IgG antibody titers in patients with aggressive periodontitis].
abstract: OBJECTIVE
  To measure the anti-Pg (porphyromonas gingivalis, Pg) IgG antibody titers in serum in patients with aggressive periodontitis (AgP); to study the association of IgG titers with periodontal status (alveolar bone loss); to analyze the age, gender or smoking status on IgG levels in patients with aggressive periodontitis.
  
  
  METHODS
  (1) Ninety-one AgP subjects with an average age of 27.6 years (females 56, males 35, and 14 male-smokers) were collected. Thirty-five healthy subjects with an average age of 29.4 years (males 10 and females 25) were also collected as control group. (2) Questionnaire, clinical evaluations and assessments of alveolar bone loss were made. (3) Patients were categorized into two groups: severe AgP group (58 subjects, with >14 teeth of moderate-severe alveolar bone loss); light-moderate group (33 subjects). (4) To collect serum sample of patients and determine the anti-Pg IgG antibody titers in serum using ELISA.
  
  
  RESULTS
  (1) The mean IgG antibody titers to Pg in AgP group (8.55 +/-3.24) were significantly higher than that in control group (4.78+/-2.58, P=0.0004). (2) No significant difference [(8.38+/-3.73) and (8.67+/-2.90), respectively] of mean anti-Pg IgG titers was found between male and female. (3) The mean of anti-Pg IgG titers (9.26+/-2.58) in elder group (aged>25) was significantly higher than that in younger patients (6.96+/-3.98, P=0.0014). (4) Smokers had significantly lower anti-Pg IgG titers (7.33+/- 3.72) than non-smokers (8.78+/-3.12, P=0.016). (5) Anti-Pg IgG titers in severe AgP group was significantly higher than that in light-moderate AgP group. (6)The results of multi-factor regression analysis showed that smoking, age and status of alveolar bone loss were the factors affecting anti-Pg IgG titers.
  
  
  CONCLUSIONS
  The titers of IgG antibody to Pg in serum were related to age, smoking and periodontal status in AgP patients.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Huan-xin
authors.initials: HX
authors.lastname: Meng
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Chen
authors.forename: Xiang-hui
authors.initials: XH
authors.lastname: Feng
authors.forename: Dong
authors.initials: D
authors.lastname: Shi
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D010520:Aggressive Periodontitis / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D016301:Alveolar Bone Loss; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D016966:Porphyromonas gingivalis / Q000276:immunology*; D012044:Regression Analysis; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G