title: Toxoplasmosis in HIV/AIDS patients in Malaysia.
abstract: Three hundred and one sera of HIV/AIDS patients were tested for anti-Toxoplasma IgG antibody by ELISA technique. The seroprevalence of toxoplasmosis was 41.2% (95% CI: 35.5-46.9) in HIV/AIDS patients. The seroprevalence was significantly higher in the Malay (57.9%) than the Chinese (38.7%), followed by the Indian patients (29.6%) (p<0.05). No possible risk factor, such as contact with cats, consumption of uncooked meat, and history of blood transfusions was found to have any significant association with the presence of anti-Toxoplasma antibody in the study sample (p>0.05). Multivariate analysis was employed to find any association between Toxoplasma seroprevalence and a single subject having single or multiple risk factors. It was found that the association was not statistically significant (p>0.05). Among the HIV/AIDS study samples, 124 (41.2%) samples were found to have positive anti-Toxoplasma antibody, the association between the presence of anti-Toxoplasma antibody and CD4 cell count was determined but no statistically significant association was found (p>0.05). During the study period, only one case of active CNS toxoplasmosis was registered and the diagnostic criteria included: clinical presentations, CT scan finding, serological evidence of anti-Toxoplasma IgG antibody, and respose to anti-Toxoplasma therapy.
authors.affiliation: Department of Parasitology, University of Malaya Medical Center, Kuala Lumpur, Malaysia. nissapat@hotmail.com
authors.forename: V
authors.initials: V
authors.lastname: Nissapatorn
authors.forename: C K C
authors.initials: CK
authors.lastname: Lee
authors.forename: S M
authors.initials: SM
authors.lastname: Cho
authors.forename: M
authors.initials: M
authors.lastname: Rohela
authors.forename: A Khirul
authors.initials: AK
authors.lastname: Anuar
authors.forename: K F
authors.initials: KF
authors.lastname: Quek
authors.forename: H M
authors.initials: HM
authors.lastname: Latt
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000913:Antibodies, Protozoan / Q000097:blood; D015153:Blotting, Western; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012959:Socioeconomic Factors; D014123:Toxoplasmosis / Q000150:complications* / Q000453:epidemiology*; D055815:Young Adult
chemical_list: D000913:Antibodies, Protozoan