Dose dependence of DNA repair in rainbow trout (Oncorhynchus mykiss) larvae exposed to UV-B radiation.
We examined survival and DNA damage in rainbow trout larvae (Oncorhynchus mykiss) resulting from a range of sublethal to lethal ultraviolet-B exposures in the presence and absence of photoreactivating radiation. We found that after low, sublethal UV-B exposures trout larvae are quite proficient at photoenzymatic repair but that this capacity decreases exponentially with the total incident UV-B dose. The relationship between the dose dependence of PER and trout development and vulnerability in fisheries and in the natural environment are discussed.
Mitchell
David L
DL
Department of Carcinogenesis, The University of Texas MD Andersen Cancer Center, 1808 Park Road 1C, Smithville, TX 78957, USA. dmitchel@mdanderson.org
Adams-Deutsch
Tristan
T
Olson
Mark H
MH
D000818:Animals; D004249:DNA Damage; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D007814:Larva / Q000528:radiation effects*; D017686:Oncorhynchus mykiss / Q000254:growth & development*; D014466:Ultraviolet Rays