title: Perioperative dexamethasone does not affect functional outcome in total hip arthroplasty.
abstract: Current trends in orthopaedic surgery have explored different forms of adjuvant treatments to minimize postoperative pain and the risk of nausea and vomiting. A small single preoperative dose of dexamethasone, as part of a comprehensive multimodal analgesic regimen in low-risk patients undergoing total hip arthroplasty (THA), provides antiemetic and opioid-sparing effects but the longer-term effects on pain, complications, or function are not known. We therefore asked whether such a routine would affect longer-term pain, complications, or function. Fifty patients undergoing elective primary THA using spinal anesthesia were initially randomized to receive either dexamethasone (40 mg intravenous) or saline placebo. The patients, anesthesiologists, nurses, and research coordinators were blinded to the study arms. The functional outcome was measured using the Harris hip score. Outcomes were assessed 6 weeks and 1 year postoperatively. We observed no difference in resting pain between the two groups at either time period. Both groups had similar functional outcome scores for the total Harris hip score and individual scoring items at each followup interval. There were no wound complications, deep infections, or osteonecrosis in the contralateral hip at 1-year followup. We recommend the addition of a small single preoperative dose of dexamethasone to a comprehensive multimodal analgesic regimen in low-risk patients given its immediate antiemetic and opioid-sparing effects, and absence of subsequent effects.
  
  
  METHODS
  Level II, therapeutic study (prospective comparative study). See the Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Division of Orthopaedic Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, Canada.
authors.forename: Stephane G
authors.initials: SG
authors.lastname: Bergeron
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Kardash
authors.forename: Olga L
authors.initials: OL
authors.lastname: Huk
authors.forename: David J
authors.initials: DJ
authors.lastname: Zukor
authors.forename: John
authors.initials: J
authors.lastname: Antoniou
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000932:Antiemetics / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip; D016009:Chi-Square Distribution; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D016059:Range of Motion, Articular; D020127:Recovery of Function; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000932:Antiemetics; D003907:Dexamethasone