title: Characterization of a PLLA-collagen I blend nanofiber scaffold with respect to growth and osteogenic differentiation of human mesenchymal stem cells.
abstract: We developed a nanofiber scaffold by blending PLLA with collagen I, suitable for bone regeneration. Among several PLLA-COLI ratios tested, cell growth was better enhanced when blends with a ratio of PLLA-COLI 4:1 were used. Here, growth as well as osteoblast differentiation of hMSC was improved when compared to PLLA nanofibers alone. Therefore, blending is a suitable tool to enhance PLLA nanofibers with respect to bone tissue engineering.
authors.affiliation: Department of Orthopedics, University of Marburg, D-35043 Marburg, Baldingerstrasse, Germany. schofer@med.uni-marburg.de
authors.forename: Markus D
authors.initials: MD
authors.lastname: Schofer
authors.forename: Ulrich
authors.initials: U
authors.lastname: Boudriot
authors.forename: Irini
authors.initials: I
authors.lastname: Leifeld
authors.forename: Romina I
authors.initials: RI
authors.lastname: Sütterlin
authors.forename: Markus
authors.initials: M
authors.lastname: Rudisile
authors.forename: Joachim H
authors.initials: JH
authors.lastname: Wendorff
authors.forename: Andreas
authors.initials: A
authors.lastname: Greiner
authors.forename: Jürgen R J
authors.initials: JR
authors.lastname: Paletta
authors.forename: Susanne
authors.initials: S
authors.lastname: Fuchs-Winkelmann
mesh_terms: D049109:Cell Proliferation; D002478:Cells, Cultured; D024042:Collagen Type I / Q000737:chemistry*; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000378:metabolism*; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D010012:Osteogenesis; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*
chemical_list: D024042:Collagen Type I; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)