Effect of epsilon-aminocaproyl-S-benzyl-L-cysteine on the activity of plasminogen activators.
The effect of epsilon-aminocaproyl-S-benzyl-L-cysteine on the activation of plasminogen by t-PA. streptokinase and urokinase has been examined using fibrinolytic method. The obtained results have been compared with the obtained results for epsilon-aminocaproic acid and trans-4-(aminomethyl)cyclohexanecarboxylic acid. The inhibition of the plasminogen activation determined with the use of epsilon-aminocaproyl-S-benzyl-L-cysteine was weaker than the inhibition determined by using antifibrinolytic aminoacids.
Bruzgo
Irena
I
Department of Organic Chemistry, Medical University of Białystok, 1 Kilińskiego St., 15-230 Białystok, Poland.
Midura-Nowaczek
Krystyna
K
Kaczyńska
Joanna
J
Krajewska
Dorota
D
D000614:Aminocaproates; D015119:Aminocaproic Acid / Q000494:pharmacology; D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D010958:Plasminogen / Q000187:drug effects* / Q000378:metabolism; D013300:Streptokinase / Q000494:pharmacology; D010959:Tissue Plasminogen Activator / Q000494:pharmacology; D014148:Tranexamic Acid / Q000494:pharmacology; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology
D000614:Aminocaproates; D000933:Antifibrinolytic Agents; D005343:Fibrinolytic Agents; C539166:epsilon-aminocaproyl-S-benzylcysteine; D014148:Tranexamic Acid; D010958:Plasminogen; D013300:Streptokinase; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator; D003545:Cysteine; D015119:Aminocaproic Acid