The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.
We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins.
Ribaya
Jeronimo P
JP
Department of Molecular Cell and Developmental Biology, and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Ranmuthu
Madhuka
M
Copeland
Jeff
J
Boyarskiy
Sergey
S
Blair
Adrienne P
AP
Hay
Bruce
B
Laski
Frank A
FA
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000502:physiology*; D010450:Endopeptidases / Q000502:physiology*; D017344:Genes, Insect; D008954:Models, Biological; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
D051017:Apoptosis Regulatory Proteins; D029721:Drosophila Proteins; D044767:Ubiquitin-Protein Ligases; D010450:Endopeptidases; C534688:ubiquitin specific protease 36, Drosophila