title: Triterpenoids with antimicrobial activity from Drypetes inaequalis.
abstract: The air-dried stems and ripe fruit of Drypetes inaequalis Hutch. (Euphorbiaceae) were studied. Four triterpene derivatives, characterized as lup-20(29)-en-3beta,6alpha-diol, 3beta-acetoxylup-20(29)-en-6alpha-ol, 3beta-caffeoyloxylup-20(29)-en-6alpha-ol and 28-betad-glucopyranosyl-30-methyl 3beta-hydroxyolean-12-en-28,30-dioate along with 10 known compounds were isolated from the whole stems. One triterpene, characterized as 3alpha-hydroxyfriedelan-25-al along with six known compounds were isolated from the ripe fruit. Their structures were established on the basis of spectroscopic analysis and chemical evidence. The triterpenes were tested for antimicrobial activity against some Gram-positive and Gram-negative bacteria, and two of them appeared to be modestly active.
authors.affiliation: Department of Organic Chemistry, University of Yaounde-1, Faculty of Science, P.O. Box 812, Yaounde, Cameroon.
authors.forename: Simon Suh
authors.initials: SS
authors.lastname: Awanchiri
authors.forename: Hanh
authors.initials: H
authors.lastname: Trinh-Van-Dufat
authors.forename: Jovita Chi
authors.initials: JC
authors.lastname: Shirri
authors.forename: Marlise Diane J
authors.initials: MD
authors.lastname: Dongfack
authors.forename: Guy Merlin
authors.initials: GM
authors.lastname: Nguenang
authors.forename: Sabrina
authors.initials: S
authors.lastname: Boutefnouchet
authors.forename: Zacharias T
authors.initials: ZT
authors.lastname: Fomum
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Seguin
authors.forename: Philippe
authors.initials: P
authors.lastname: Verite
authors.forename: François
authors.initials: F
authors.lastname: Tillequin
authors.forename: Jean
authors.initials: J
authors.lastname: Wandji
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D014315:Triterpenes