Soluble CD40 ligand and soluble P-selectin levels in Gilbert's syndrome: a link to protection against atherosclerosis?
OBJECTIVE
To investigate the role of CD40 ligand and P-selectin in the mechanism of decreased incidence of cardiovascular disease in Gilbert's syndrome (GS).


METHODS
The soluble forms of CD40 ligand (sCD40L) and P-selectin (sP-selectin), and high sensitive C reactive protein (hs-CRP) levels were investigated in subjects with GS (n=25) and compared to healthy controls (n=53).


RESULTS
sCD40L and hs-CRP levels were significantly lower in GS compared to the controls (0.33+/-0.27 vs 0.71+/-0.37 ng/mL, p<0.001 and 0.51+/-0.45 vs 1.16+/-1.31 mg/L, p=0.046, respectively). Both sCD40L and hs-CRP were negatively correlated with total bilirubin (r=-0.5, p<0.001 and r=-0.34, p=0.002, respectively). sP-selectin levels were lower in GS when compared to the controls but the difference did not reach statistical significance (p=0.052). No correlation was found between the plasma levels of sCD40L, sP-selectin and hs-CRP.


CONCLUSIONS
These novel findings suggest that reduced sCD40L and hs-CRP concentrations may have a role in the mechanism of protection against atherosclerosis in GS.
Tapan
Serkan
S
Department of Medical Biochemistry, Gulhane School of Medicine, 06108 Etlik, Ankara, Turkey. serkantapan7@yahoo.com
Dogru
Teoman
T
Tasci
Ilker
I
Ercin
Cemal Nuri
CN
Ozgurtas
Taner
T
Erbil
Mehmet Kemal
MK
D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000517:prevention & control*; D002097:C-Reactive Protein / Q000378:metabolism; D023201:CD40 Ligand / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005878:Gilbert Disease / Q000097:blood*; D006801:Humans; D008297:Male; D019007:P-Selectin / Q000097:blood*; D055815:Young Adult
D019007:P-Selectin; D023201:CD40 Ligand; D002097:C-Reactive Protein