title: Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women.
abstract: OBJECTIVE
  There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this association.
  
  
  METHODS
  Eight hundred and fifteen subjects received routine checkups. After excluding subjects with factors affecting bone metabolism and cardiovascular disease, 467 subjects were analysed.
  
  
  METHODS
  Coronary calcification was measured with MDCT and BMD was measured with dual X-ray absorptiometry (DXA).
  
  
  RESULTS
  The BMD of the femur and the lumbar spine (L-spine) were negatively associated with the coronary calcium score (CCS) after adjusting for age in women but not in men. This inverse correlation was stronger in women with a longer time since menopause (r = -0.35 at femur, postmenopausal women vs. r = -0.10 at femur, premenopausal women, P < 0.05), and it was stronger at the femur than in the L-spine (r = -0.35 at femur vs. r = -0.16 at L-spine, P < 0.01). The relationship was also stronger in postmenopausal women with osteoporosis and osteopaenia than in women with normal BMD. The lower BMD was associated with higher coronary plaque burdens and multidiseased coronary vessels in both men and women (P < 0.01).
  
  
  CONCLUSIONS
  Increased CCS and subclinical atherosclerosis of plaque burdens as revealed by MDCT was associated with a low BMD in all women, independent of cardiovascular risk factors and age.
authors.affiliation: Seoul National University College of Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Korea.
authors.forename: Sung Hee
authors.initials: SH
authors.lastname: Choi
authors.forename: Jee Hyun
authors.initials: JH
authors.lastname: An
authors.forename: Soo
authors.initials: S
authors.lastname: Lim
authors.forename: Bo Kyung
authors.initials: BK
authors.lastname: Koo
authors.forename: Se Eun
authors.initials: SE
authors.lastname: Park
authors.forename: Hyuck Jae
authors.initials: HJ
authors.lastname: Chang
authors.forename: Sang Il
authors.initials: SI
authors.lastname: Choi
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Park
authors.forename: Kyong Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Hak Chul
authors.initials: HC
authors.lastname: Jang
authors.forename: Chan Soo
authors.initials: CS
authors.lastname: Shin
mesh_terms: D015519:Bone Density / Q000502:physiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D017697:Premenopause / Q000378:metabolism*; D014057:Tomography, X-Ray Computed