Chemical constituents of the stems of Ephedra sinica.
A new naphthalene derivative, 1-methyl-2,3-methylenedioxy-6-naphthalenecarboxylic acid methyl ester (1), and a new alkaloid, ( +/- )-1-phenyl-2-imido-1-propanol (2), together with the four known compounds, ephedrine, pseudoephedrine, N-methylephedrine, and 6-methoxykynurenic acid, have been isolated from the stems of Ephedra sinica, a famous traditional Chinese herbal medicine. The structures of 1 and 2 were determined by spectroscopic methods, including 1D- and 2D-NMR experiments as well as HR-EI-MS analysis.
Zhao
Wei
W
Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources of Chinese Herbal Medicine, Ministry of Education), Beijing, China.
Deng
An-Jun
AJ
Du
Guan-Hua
GH
Zhang
Jin-Lan
JL
Li
Zhi-Hong
ZH
Qin
Hai-Lin
HL
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D029790:Ephedra sinica / Q000737:chemistry*; D004809:Ephedrine / Q000031:analogs & derivatives / Q000302:isolation & purification; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D054199:Pseudoephedrine / Q000302:isolation & purification
C539876:1-methyl-2,3-methylenedioxy-6-naphthalenecarboxylic acid methyl ester; D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D009281:Naphthalenes; C041707:N-methylephedrine; D054199:Pseudoephedrine; D004809:Ephedrine