title: Risk factors for incident diabetes mellitus among HIV-infected patients receiving combination antiretroviral therapy in Taiwan: a case-control study.
abstract: OBJECTIVE
  Recent studies suggest that patients with HIV infection are at increased risk for incident diabetes mellitus (DM). We investigated the incidence and risk factors of DM among HIV-infected patients receiving combination antiretroviral therapy (CART) in Taiwan.
  
  
  METHODS
  Incident cases of DM were identified among HIV-infected patients at the National Taiwan University Hospital between 1993 and 2006. A retrospective case-control study was conducted after matching cases with controls for sex, age at HIV diagnosis, year of HIV diagnosis, mode of HIV transmission and baseline CD4 lymphocyte count. A multivariate analysis was performed to identify risk factors for incident DM among HIV-infected patients.
  
  
  RESULTS
  In 824 HIV-infected patients eligible for analysis, 50 cases of incident DM were diagnosed, resulting in an incidence of 13.1 cases per 1000 person-years of follow-up. In total, 100 matched controls were identified. Risk factors for incident DM were a family history of DM [odds ratio (OR) 2.656; 95% confidence interval (CI) 1.209-5.834], exposure to zidovudine (OR 3.168; 95% CI 1.159-8.661) and current use of protease inhibitors (OR 2.528; 95% CI 1.186-5.389).
  
  
  CONCLUSIONS
  Incident DM was associated with a family history of DM, exposure to zidovudine and current use of protease inhibitors in HIV-infected patients receiving CART in Taiwan.
authors.affiliation: Centers for Disease Control, Department of Health, Taipei, Taiwan.
authors.forename: Y-C
authors.initials: YC
authors.lastname: Lo
authors.forename: M-Y
authors.initials: MY
authors.lastname: Chen
authors.forename: W-H
authors.initials: WH
authors.lastname: Sheng
authors.forename: S-M
authors.initials: SM
authors.lastname: Hsieh
authors.forename: H-Y
authors.initials: HY
authors.lastname: Sun
authors.forename: W-C
authors.initials: WC
authors.lastname: Liu
authors.forename: P-Y
authors.initials: PY
authors.lastname: Wu
authors.forename: C-H
authors.initials: CH
authors.lastname: Wu
authors.forename: C-C
authors.initials: CC
authors.lastname: Hung
authors.forename: S-C
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000145:classification; D018791:CD4 Lymphocyte Count; D002681:China / Q000208:ethnology; D003920:Diabetes Mellitus / Q000139:chemically induced / Q000453:epidemiology*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004812:Epidemiologic Methods; D005192:Family Health; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult; D015215:Zidovudine / Q000009:adverse effects*
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine