Comparison of effects of anaesthesia with desflurane and enflurane on liver function.
BACKGROUND
Although most general anaesthesia procedures are performed without any complications, volatile agents may have adverse effects on various living systems. This study aimed to compare the effects of desflurane and enflurane on liver function.


METHODS
40 patients, who were in the ASA I-III risk groups and were planned to undergo head and neck surgery of at least three hours' duration, were randomly divided into two groups: the desflurane (Group D) and enflurane groups (Group E). Venous blood samples (5 ml) of the patients were obtained before anaesthesia induction, in the postoperative first hour and on the first and seventh days. The samples were centrifuged and then stored at -80 degrees Celsius until the determination of glutathione S-transferase (GST) levels. For maintenance of anaesthesia in Group D, desflurane (6 percent) was used, while in Group E, enflurane (1.2 percent) was used.


RESULTS
GST levels were significantly higher in Group E in the postoperative first hour (p-value is 0.002), and on the first day (p-value is 0.025) and seventh day (p-value is 0.035), although there were no differences preoperatively (p-value is more than 0.05). When postoperative levels were compared with preoperative levels, the postoperative GST levels of Group E were significantly higher (first hour [p-value is 0.008], first day [p-value is 0.010], seventh day [p-value is 0.038]).


CONCLUSIONS
Subclinical hepatic injury after anaesthesia continues to be an issue of interest, particularly with the development of new, more sensitive methods of measuring GST levels. The increase in GST concentration after anaesthesia is thought to be a result of reduced hepatic blood flow. This study has shown that desflurane has fewer effects than enflurane on liver function tests in lengthy operations of up to 330 minutes.
Arslan
M
M
Department of Anaesthesiology and Reanimation, Faculty of Medicine, Gazi University, Ankara, Turkey. marslan36@yahoo.com
Kurtipek
O
O
Dogan
A T
AT
Unal
Y
Y
Kizil
Y
Y
Nurlu
N
N
Kamaci
S
S
Kavutcu
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D000704:Analysis of Variance; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D016009:Chi-Square Distribution; D000077335:Desflurane; D004737:Enflurane / Q000009:adverse effects*; D005260:Female; D005982:Glutathione Transferase / Q000097:blood; D006801:Humans; D007530:Isoflurane / Q000009:adverse effects / Q000031:analogs & derivatives*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D018685:Anesthetics, Inhalation; D004737:Enflurane; D000077335:Desflurane; D007530:Isoflurane; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase