title: Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines.
abstract: A novel synthesis of 3-substituted 4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with primary amines has been developed. Under mild reaction conditions, the products were achieved in good yield from commercially available starting materials.
authors.affiliation: Research & Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543, USA.
authors.forename: Zili
authors.initials: Z
authors.lastname: Xiao
authors.forename: Michael G
authors.initials: MG
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Percy H
authors.initials: PH
authors.lastname: Carter
mesh_terms: D000588:Amines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D052999:Quinazolinones