A peroxisome proliferator-activated receptor-gamma agonist and other constituents from Chromolaena odorata.
Peroxisome proliferator-activated receptors (PPARs) are key regulators of lipid and glucose metabolism and have become important therapeutic targets for various diseases. The phytochemical investigation of the chloroform-soluble extract of Chromolaena odorata led to the isolation of a PPAR-gamma agonist, (9 S,13 R)-12-oxo-phytodienoic acid (1), together with 12 other compounds. The structures of chromomoric acid G (2), a new dehydrogenated derivative of 1, and chromolanone (3) were elucidated based on spectroscopic methods. Compound 1 showed a significant effect on PPAR-gamma activation in comparison with rosiglitazone. However, compound 2 was inactive, suggesting that the dehydrogenation of the prostaglandin-like structure in 1 abrogates its PPAR-gamma agonistic activity.
Dat
Nguyen Tien
NT
Molecular Cancer Research Center, Korean Research Institute of Biosciences and Biotechnology, Daejeon, Korea.
Lee
Kyeong
K
Hong
Young-Soo
YS
Kim
Young Ho
YH
Minh
Chau Van
CV
Lee
Jung Joon
JJ
D036604:Chromolaena / Q000737:chemistry*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D047495:PPAR gamma / Q000819:agonists*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D011453:Prostaglandins; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D005419:Flavonoids; D007004:Hypoglycemic Agents; D047495:PPAR gamma; D010936:Plant Extracts; D011453:Prostaglandins; D045162:Thiazolidinediones; C543981:chromolanone; C543982:chromomoric acid G; D000077154:Rosiglitazone; C025999:12-oxophytodienoic acid