title: High-sensitivity C-reactive protein at different stages of atherosclerosis: results of the INVADE study.
abstract: Evidence on the role of high-sensitivity C-reactive protein (hsCRP) at different stages of atherosclerosis is limited. We therefore analyzed the relationship between hsCRP and measures of subclinical and advanced atherosclerosis in a population-based sample of the INVADE study (n = 3,092, >55 years). The parameters of interest were IMT, ABI, and the stage of atherosclerosis. Differences between participants with normal and pathological hsCRP were analyzed by t test for independent samples or Fishers' exact test. Differences of hsCRP between IMT quartiles, ABI quartiles, and different stages of atherosclerosis were analyzed by one-way ANOVA. Adjusted stepwise multiple linear regression analysis (IMT and ABI) and adjusted analysis of variance (stage of atherosclerosis) were performed, including significant baseline parameters as covariates. ANOVA showed significant differences of hsCRP among IMT quartiles, ABI quartiles, and patients with and without atherosclerosis. The adjusted analyses confirmed that the effects of IMT, ABI, and atherosclerosis on hsCRP were independent from other significant baseline parameters, but did not yield a significant difference between subclinical and advanced stages of atherosclerosis. The present analysis indicates an independent relationship between hsCRP and both IMT and ABI as measures of subclinical atherosclerosis. The comparison of subclinical and advanced stages of atherosclerosis yielded no significant difference, indicating that hsCRP is sensitive to identify vascular risk patients, but not suited to monitor progression of the disease.
authors.affiliation: Department of Psychiatry, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, Muenchen 81675, Germany. csh76@gmx.de
authors.forename: Carla
authors.initials: C
authors.lastname: Schulze Horn
authors.forename: Ruediger
authors.initials: R
authors.lastname: Ilg
authors.forename: Kerstin
authors.initials: K
authors.lastname: Sander
authors.forename: Horst
authors.initials: H
authors.lastname: Bickel
authors.forename: Claus
authors.initials: C
authors.lastname: Briesenick
authors.forename: Bernhard
authors.initials: B
authors.lastname: Hemmer
authors.forename: Holger
authors.initials: H
authors.lastname: Poppert
authors.forename: Dirk
authors.initials: D
authors.lastname: Sander
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis* / Q000378:metabolism*; D016893:Carotid Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005858:Germany; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016909:Tibial Arteries / Q000503:physiopathology; D014463:Ultrasonography / Q000379:methods; D015854:Up-Regulation / Q000502:physiology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein