Cytokine and nitric oxide production in an adult patient with staphylococcal scalded skin syndrome.
Staphylococcal scalded-skin syndrome (SSSS) is an exfoliative dermatitis resultant from the infection with exfoliative-toxin-producing (ET) Staphylococcus aureus. This syndrome usually occurs in children, while adult cases are generally linked to renal-deficiency or immunossupresion. A case of a 74 year old woman presenting SSSS after hospital admission due to cardiovascular disorders is presented and discussed. Cytokines (TNF-alpha, IFN-gamma, IL-6, IL-13 and IL-10) and nitric oxide (NO) production in vitro by whole blood leukocytes (WBL) were investigated. Leukocytes stimulated by lipopolysaccharide or phytohemagglutinin produced increased IFN-gamma, TNF-alpha, IL-13 and NO levels after treatment. Based on these results, immunological aspects of the disease are discussed.
Castellano
Lúcio Roberto
LR
Laboratório de Imunologia, Universidade Federal do Triâingulo Mineiro, Uberaba, MG, Brasil. lucio@mednet.com.br
Silva-Teixeira
David Nascimento
DN
Antonelli
Elida J
EJ
Rodrigues
Virmondes
V
Cavalcanti-Cordeiro
Maria Bernarda
MB
D000368:Aged; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D013206:Staphylococcal Scalded Skin Syndrome / Q000276:immunology / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D018793:Interleukin-13; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D009569:Nitric Oxide; D007371:Interferon-gamma