title: Selective deblurring for improved calcification visualization and quantification in carotid CT angiography: validation using micro-CT.
abstract: Visualization and quantification of small structures with computed tomography (CT) is hampered by the limited spatial resolution of the system. Histogram-based selective deblurring (HiSD) is a deconvolution method that restores small high-density structures, i.e., calcifications, of a CT image, using the high-intensity voxel information of the deconvolved image, while preserving the original hounsfield Units (HUs) in the remaining tissues. In this study, high resolution micro-CT data are used to validate the potential of HiSD to improve calcium visualization and quantification in the carotid arteries on in vivo contrast-enhanced CTA data. The evaluation is performed qualitatively and quantitatively on 15 atherosclerotic plaques obtained from ten different patients. HiSD in combination with vessel segmentation significantly improves calcification visualization and quantification on in vivo contrast-enhanced CT images. Calcification blur is reduced, while avoiding noise amplification and edge-ringing artifacts in the surrounding tissues. Calcification quantification errors are reduced by 23.5% on average.
authors.affiliation: Biomedical Imaging Group Rotterdam (BIGR), the Department of Radiology, Erasmus MC-University Medical Center of Rotterdam, 3015 GE Rotterdam, The Netherlands. empar.rh@gmail.com
authors.forename: Empar
authors.initials: E
authors.lastname: Rollano-Hijarrubia
authors.forename: Rashindra
authors.initials: R
authors.lastname: Manniesing
authors.forename: Wiro J
authors.initials: WJ
authors.lastname: Niessen
mesh_terms: D000792:Angiography / Q000379:methods*; D050197:Atherosclerosis / Q000000981:diagnostic imaging*; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D016893:Carotid Stenosis / Q000000981:diagnostic imaging*; D003627:Data Interpretation, Statistical; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016011:Normal Distribution; D015203:Reproducibility of Results; D055114:X-Ray Microtomography / Q000379:methods*