title: Design, synthesis, and biological evaluation of levoglucosenone-derived ras activation inhibitors.
abstract: A panel of new potential Ras ligands was generated by decorating a tricyclic levoglucosenone-derived scaffold with aromatic moieties. Some members of the panel show in vitro inhibitory activity toward the nucleotide exchange process on Ras and are toxic to some human cancer cell lines.
authors.affiliation: B. U. Oncology, Nerviano Medical Sciences, MI, Italy.
authors.forename: Christian
authors.initials: C
authors.lastname: Müller
authors.forename: Maria Antonia
authors.initials: MA
authors.lastname: Gomez-Zurita Frau
authors.forename: Dario
authors.initials: D
authors.lastname: Ballinari
authors.forename: Sonia
authors.initials: S
authors.lastname: Colombo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Bitto
authors.forename: Enzo
authors.initials: E
authors.lastname: Martegani
authors.forename: Cristina
authors.initials: C
authors.lastname: Airoldi
authors.forename: Anske Stephanie
authors.initials: AS
authors.lastname: van Neuren
authors.forename: Matthias
authors.initials: M
authors.lastname: Stein
authors.forename: Jörg
authors.initials: J
authors.lastname: Weiser
authors.forename: Carlo
authors.initials: C
authors.lastname: Battistini
authors.forename: Francesco
authors.initials: F
authors.lastname: Peri
mesh_terms: D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005947:Glucose / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018631:ras Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; C512757:1,6-anhydro-3,4-dideoxyhex-3-enopyran-2-ulose; D018631:ras Proteins; D005947:Glucose