Cefoperazone induced gastro-intestinal haemorrhage. A case report.
Cefoperazone is a parenteral third generation cephalosporin which is active against many Gram positive and Gram negative organisms. Cefaperazone, like other cephalosporins which contain methyltiotetrazole side chain, can cause hypoprotrombinaemia and bleeding problems. Here we report a nine-year old child with Meckel's diverticulum who had cefoperazone induced massive gastrointestinal bleeding on the fifth day following the operation.
Ozen
I O
IO
Gazi University Medical Faculty, Department of Pediatric Surgery, Ankara, Turkey.
Moralioğlu
S
S
Karabulut
R
R
Bagbanci
B
B
Turkyilmaz
Z
Z
Demirogullari
B
B
Sonmez
K
K
Basaklar
A C
AC
Kale
N
N
D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000933:Antifibrinolytic Agents / Q000008:administration & dosage; D001780:Blood Coagulation Tests; D002438:Cefoperazone / Q000009:adverse effects*; D002648:Child; D006471:Gastrointestinal Hemorrhage / Q000097:blood / Q000139:chemically induced*; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced; D007273:Injections, Intramuscular; D008297:Male; D008467:Meckel Diverticulum / Q000601:surgery*; D011183:Postoperative Complications / Q000139:chemically induced*; D014812:Vitamin K / Q000008:administration & dosage
D000900:Anti-Bacterial Agents; D000933:Antifibrinolytic Agents; D014812:Vitamin K; D002438:Cefoperazone