title: Preparation, structure and drug release behaviour of chitosan-based nanofibres.
abstract: Biomimetic polymeric nanofibres are of great interest in tissue engineering and wound repair because of their structural similarity to extracellular matrix. In this work, biomimetic chitosan-based nanofibres with various diameters were prepared by ionically cross-linking with tripolyphosphate (TPP) in adipic acid medium and characterised using transmission electron microscopy, X-ray diffraction and Fourier-transform infrared spectroscopy. Using dexamethasone sodium phosphate (DMP) and bovine serum albumin (BSA) as low and high molecular-weight bioactive molecule models, respectively, drug loading and in vitro release behaviours of chitosan-TPP nanofibres were investigated. The drug-loaded chitosan-TPP nanofibres showed a prolonged release profile with three distinct stages in physiological conditions because of the complicated release mechanisms involving diffusion of the drug and degradation of the nanofibre, and BSA-loaded nanofibres showed a smaller release rate than DMP-loaded nanofibres. It is proposed that biomimetic chitosan-based nanofibres may be of use in tissue engineering for sustained release of bioactive agents.
authors.affiliation: Jinan University, Department of Materials Science and Engineering, College of Science and Engineering, and Guangzhou Overseas Chinese Hospital, Guangzhou, People's Republic of China.
authors.forename: R
authors.initials: R
authors.lastname: Zeng
authors.forename: M
authors.initials: M
authors.lastname: Tu
authors.forename: H-W
authors.initials: HW
authors.lastname: Liu
authors.forename: J-H
authors.initials: JH
authors.lastname: Zhao
authors.forename: Z-G
authors.initials: ZG
authors.lastname: Zha
authors.forename: C-R
authors.initials: CR
authors.lastname: Zhou
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D003907:Dexamethasone / Q000031:analogs & derivatives / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D011122:Polyphosphates / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000378:metabolism; D023822:Tissue Engineering / Q000295:instrumentation; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D011122:Polyphosphates; D012710:Serum Albumin, Bovine; C004180:dexamethasone 21-phosphate; D003907:Dexamethasone; D048271:Chitosan; C005692:triphosphoric acid