title: SIK1/SOS2 networks: decoding sodium signals via calcium-responsive protein kinase pathways.
abstract: Changes in cellular ion levels can modulate distinct signaling networks aimed at correcting major disruptions in ion balances that might otherwise threaten cell growth and development. Salt-inducible kinase 1 (SIK1) and salt overly sensitive 2 (SOS2) are key protein kinases within such networks in mammalian and plant cells, respectively. In animals, SIK1 expression and activity are regulated in response to the salt content of the diet, and in plants SOS2 activity is controlled by the salinity of the soil. The specific ionic stress (elevated intracellular sodium) is followed by changes in intracellular calcium; the calcium signals are sensed by calcium-binding proteins and lead to activation of SIK1 or SOS2. These kinases target major plasma membrane transporters such as the Na(+),K(+)-ATPase in mammalian cells, and Na(+)/H(+) exchangers in the plasma membrane and membranes of intracellular vacuoles of plant cells. Activation of these networks prevents abnormal increases in intracellular sodium concentration.
authors.affiliation: Membrane Signaling Networks, Atherosclerosis Research Unit, Department of Medicine, Karolinska Institutet, Karolinska University Hospital-Solna, Stockholm, Sweden. alejandro.bertorello@ki.se
authors.forename: Alejandro Mario
authors.initials: AM
authors.lastname: Bertorello
authors.forename: Jian-Kang
authors.initials: JK
authors.lastname: Zhu
mesh_terms: D020013:Calcium Signaling / Q000502:physiology*; D008954:Models, Biological; D018521:Plant Physiological Phenomena; D011494:Protein Kinases / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D015222:Sodium Channels / Q000502:physiology*; D020664:Son of Sevenless Proteins / Q000378:metabolism*
chemical_list: C485509:SOS2 protein, human; D015222:Sodium Channels; D020664:Son of Sevenless Proteins; D012964:Sodium; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; C120299:Sik1 protein, rat