title: Morpholine containing CB2 selective agonists.
abstract: Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing.
authors.affiliation: Department of Medicinal Chemistry, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, PO Box 368, Ridgefield, CT 06877-0368, USA.
authors.forename: Renée
authors.initials: R
authors.lastname: Zindell
authors.forename: Doris
authors.initials: D
authors.lastname: Riether
authors.forename: Todd
authors.initials: T
authors.lastname: Bosanac
authors.forename: Angela
authors.initials: A
authors.lastname: Berry
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Gemkow
authors.forename: Andreas
authors.initials: A
authors.lastname: Ebneth
authors.forename: Sabine
authors.initials: S
authors.lastname: Löbbe
authors.forename: Ernest L
authors.initials: EL
authors.lastname: Raymond
authors.forename: Diane
authors.initials: D
authors.lastname: Thome
authors.forename: Daw-Tsun
authors.initials: DT
authors.lastname: Shih
authors.forename: David
authors.initials: D
authors.lastname: Thomson
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002460:Cell Line; D002626:Chemistry, Pharmaceutical / Q000379:methods; D015195:Drug Design; D006801:Humans; D007249:Inflammation; D051379:Mice; D008956:Models, Chemical; D015394:Molecular Structure; D009025:Morpholines / Q000138:chemical synthesis* / Q000494:pharmacology; D043885:Receptor, Cannabinoid, CB2 / Q000819:agonists* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009025:Morpholines; D043885:Receptor, Cannabinoid, CB2; C037574:morpholine