Metabolic acidosis in AIDS patients.
OBJECTIVE
Metabolic acidosis (MA) is a frequent and serious complication in HIV-infected patients. The aim of the study is to compare patients with and without MA associated with HIV.


METHODS
Patients were retrospectively studied involving all HIV-infected patients with blood gas analysis performed during hospital stay admitted to a single hospital between April 2004 and July 2006. Statistical analysis was performed using SPSS 10.0 for Windows.


RESULTS
Included in the study were 159 HIV patients, 72 cases (45.3%) with MA and 87 cases (54.7%) without. The comparison of both groups showed a mean arterial pH of 7.24 +/- 0.08 vs. 7.44 +/- 0.05, HCO(3) 12 +/- 5.7 vs. 21 +/- 5.1 mEq/L, serum urea 81 +/- 68 mg/dL vs. 39 +/- 46 mg/dL and serum creatinine 2.7 +/- 2.6 mg/dL vs. 1.2 +/- 1.9 mg/dL in MA-HIV and non-MA-HIV, respectively (p <0.05). Antiretroviral therapy (ART) was being administered to 38 subjects (52.8%) in MA-HIV group and 45 (51.7%) in non-MA-HIV group (p = 0.57). There was no association between the use of ART and MA. Mortality was higher in patients with acidosis (52.7 vs. 17.2%, p <0.0001).


CONCLUSIONS
In the present study, MA was associated with acute kidney injury and increased mortality. There was no association between the use of ART and MA.
Daher
Elizabeth F
EF
Department of Internal Medicine, Hospital Universitário Walter Cantídio, Universidade Federal do Ceará, Fortaleza, Brazil. ef.daher@uol.com.br
Cezar
Lia C
LC
Silva
Geraldo B
GB
Lima
Rafael S
RS
Damasceno
Lisandra S
LS
Lopes
Ericka B
EB
Nunes
Fernanda R
FR
Mota
Rosa S
RS
Libório
Alexandre B
AB
D000138:Acidosis / Q000453:epidemiology* / Q000209:etiology* / Q000401:mortality; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy / Q000401:mortality; D058186:Acute Kidney Injury / Q000150:complications* / Q000401:mortality; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001784:Blood Gas Analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors
D003404:Creatinine