title: A common variant in MTNR1B, encoding melatonin receptor 1B, is associated with type 2 diabetes and fasting plasma glucose in Han Chinese individuals.
abstract: OBJECTIVE
  Recently, three groups independently reported that variation in MTNR1B, the gene encoding melatonin receptor 1B, was associated with an increased risk of type 2 diabetes, increased fasting plasma glucose and impaired insulin secretion in populations of European ancestry. In the present study, we investigated whether a single MTNR1B polymorphism was associated with type 2 diabetes in Han Chinese individuals, to elucidate whether this is a cross-populational effect.
  
  
  METHODS
  The MTNR1B variant rs10830963 was genotyped in 1,165 type 2 diabetic patients and 1,105 normoglycaemic control individuals of southern Han Chinese ancestry who were residents of the metropolitan area of Shanghai. The risk of developing type 2 diabetes was calculated using a logistic regression model adjusted for age, sex and BMI. A possible association with fasting plasma glucose was analysed in the normoglycaemic control individuals using a multiple linear regression analysis with adjustments for age, sex and BMI.
  
  
  RESULTS
  The genetic variant rs10830963 was associated with an increased risk of type 2 diabetes in our Han Chinese cohort (OR 1.16, 95% CI 1.03-1.31, p = 0.015). As previously described, the risk variant was also associated with increased fasting plasma glucose, showing an increase of 0.068 mmol/l (95% CI 0.036-0.100, p = 4 x 10(-5)) per risk allele.
  
  
  CONCLUSIONS
  A common variant in the MTNR1B gene is associated with an increased risk of type 2 diabetes and increased fasting plasma glucose in Han Chinese, suggesting an important role for this polymorphism in populations of different ethnic and environmental backgrounds.
authors.affiliation: Department of Clinical Sciences, CRC Malmö University Hospital, Lund University Diabetes Center, Malmö, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Rönn
authors.forename: J
authors.initials: J
authors.lastname: Wen
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
authors.forename: B
authors.initials: B
authors.lastname: Lu
authors.forename: Y
authors.initials: Y
authors.lastname: Du
authors.forename: L
authors.initials: L
authors.lastname: Groop
authors.forename: R
authors.initials: R
authors.lastname: Hu
authors.forename: C
authors.initials: C
authors.lastname: Ling
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D015992:Body Mass Index; D002681:China; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics*; D005215:Fasting; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D012016:Reference Values; D012044:Regression Analysis; D012307:Risk Factors; D014505:Urban Population
chemical_list: D001786:Blood Glucose; D044123:Receptor, Melatonin, MT2; D004247:DNA