title: General chromatographic NMR method in liquid state for synthetic chemistry: polyvinylpyrrolidone assisted DOSY experiments.
abstract: A polymer assisted liquid state DOSY NMR technique, to extract the spectra of the individual components from mixtures in CDCl(3), is demonstrated. The enhancement of diffusion coefficient differences is achieved using a soluble polymer, polyvinylpyrrolidone, as the "stationary phase". The "separation" of analytes resembles normal-phase chromatography, for example, TLC. This method provides a fast, cheap, and simple technique to resolve the NMR spectra of complex mixtures.
authors.affiliation: Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014, University of Helsinki, Finland.
authors.forename: Jari S
authors.initials: JS
authors.lastname: Kavakka
authors.forename: Ilkka
authors.initials: I
authors.lastname: Kilpeläinen
authors.forename: Sami
authors.initials: S
authors.lastname: Heikkinen