Predictors of urinary albumin excretion in women with polycystic ovary syndrome.
OBJECTIVE
To evaluate urinary albumin excretion (UAE) in normotensive and nondiabetic women with polycystic ovary syndrome (PCOS) in relation to their clinical, endocrine, and metabolic profiles.


METHODS
Observational study.


METHODS
University fertility center.


METHODS
Sixty-three women with PCOS were evaluated.


METHODS
Clinical assessments and urine and blood testing.


METHODS
Urinary albumin excretion, systolic and diastolic blood pressure, serum levels of LH, FSH, PRL, T, 17-hydroxyprogesterone, glucose, insulin, lipids, C-reactive protein, and 24-hour urinary free cortisol.


RESULTS
In univariate and multivariate correlation analysis, UAE correlated with diastolic blood pressure, insulin area under the curve during glucose tolerance test, PRL, and 17-hydroxyprogesterone. Overt microalbuminuria was detected in a significant proportion of subjects.


CONCLUSIONS
Urinary albumin excretion in women with PCOS correlates well with other cardiovascular risk factors. Because the relationship between UAE and adverse cardiovascular events is continuous, evaluation of UAE in the presence of PCOS may provide clinically relevant information and may aid in selecting appropriate patients for more aggressive treatment of likely aggravating factors, such as hyperinsulinemia or borderline hypertension.
Duleba
Antoni J
AJ
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, California, USA. ajduleba@ucdavis.edu
Ahmed
Ibrahim M
IM
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000378:metabolism; D000419:Albuminuria / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000652:urine*; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
D000418:Albumins; D001786:Blood Glucose; D007328:Insulin; D019326:17-alpha-Hydroxyprogesterone; D002097:C-Reactive Protein