title: Direct C-H borylation and C-H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines.
abstract: Novel direct C-H borylations of 7-deazapurines to position 8 by B2pin2 under Ir catalysis were followed by Suzuki cross-couplings with aryl halides and other functional group transformations to give diverse 8-substituted 7-deazaadenines.
authors.affiliation: Institute of Organic Chemistry and Biochemistry, v.v.i., Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center, Flemingovo nam. 2, CZ-16610, Prague 6, Czech Republic.
authors.forename: Martin
authors.initials: M
authors.lastname: Klecka
authors.forename: Radek
authors.initials: R
authors.lastname: Pohl
authors.forename: Blanka
authors.initials: B
authors.lastname: Klepetárová
authors.forename: Michal
authors.initials: M
authors.lastname: Hocek
mesh_terms: D001896:Boron Compounds / Q000737:chemistry; D002384:Catalysis; D011687:Purines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D014372:Tubercidin
chemical_list: D001896:Boron Compounds; D011687:Purines; D011743:Pyrimidines; D011758:Pyrroles; D014372:Tubercidin