Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats.
We investigated the effects of a high-fructose (HF) diet on cardiovascular risks in Sprague-Dawley rats. Twelve rats were randomly assigned to standard chow or HF diet for 20 weeks. Systolic blood pressure and circulating insulin, total cholesterol, and triacylglycerol levels were significantly higher in the HF group. Aortic sections appeared normal, but liver sections from the HF group showed lipid accretion, mild inflammation, and bile pigmentation. Liver samples from the HF group showed significantly higher total lipid levels and changes in fatty acid profile. Levels of 16:0, cis-9-18:2, cis-11-20:1, cis-13-20:1, cis-11-20:2 and 24:0 were significantly raised in the phospholipid fraction. Lower levels of cis-11-18:1, cis-9-18:2, and cis-11-20:1 and increased levels of 16:1, cis-9-18:1, and cis-13-20:1 were found in the non-esterified fatty acid fraction. HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats.
Abdullah
Mohammad M
MM
Departments of Human Nutritional Sciences, The University of Manitoba and St. Boniface General Hospital Research Centre, Winnipeg, MB, Canada.
Riediger
Natalie N
NN
Chen
Qilin
Q
Zhao
Zhaohui
Z
Azordegan
Nazila
N
Xu
Zuyuan
Z
Fischer
Gabor
G
Othman
Rgia A
RA
Pierce
Grant N
GN
Tappia
Paramjit S
PS
Zou
Jitao
J
Moghadasian
Mohammed H
MH
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000453:epidemiology; D016207:Cytokines / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000494:pharmacology; D004435:Eating; D005632:Fructose / Q000008:administration & dosage* / Q000494:pharmacology; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D050152:Intra-Abdominal Fat / Q000378:metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012307:Risk Factors
D001786:Blood Glucose; D016207:Cytokines; D004040:Dietary Carbohydrates; D007328:Insulin; D008055:Lipids; D005632:Fructose