Oxidative stress is increased in serum from Mexican patients with relapsing-remitting multiple sclerosis.
OBJECTIVE
To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis.


METHODS
Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification.


RESULTS
Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.
Ortiz
Genaro Gabriel
GG
Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. genarogabriel@yahoo.com
Macías-Islas
Miguel Angel
MA
Pacheco-Moisés
Fermín P
FP
Cruz-Ramos
José A
JA
Sustersik
Silvia
S
Barba
Elías Alejandro
EA
Aguayo
Adriana
A
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008800:Mexico; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood*; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D055815:Young Adult
D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D008315:Malondialdehyde; D005979:Glutathione Peroxidase