Is ethanol consumption beneficial for oral lichen planus?
Oral lichen planus (OLP), one of the most common oral mucosa diseases, is an auto-immune disease characterized histologically by basal keratinocyte damage and interface lymphocyte reaction. Previous studies have proved ethanol consumption can suppress immune system in many aspects, including inhibiting lymphocytes proliferation and their function, modifying antigen-presentation, etc. Pathogenesis of the OLP mainly comprises of antigen-presentation, lymphocytes activation and keratinocyte apoptosis, all of which may be inhibited by ethanol consumption. Thus, we put forth our hypothesis that chronic ethanol consumption may decrease OLP incidence and OLP treatment except the erosive type may benefit from ethanol consumption. In the discussion, we also talk about the extent of ethanol consumption. Still ethanol abuse is not commended, for it may increase incidence of many other diseases, and moderate ethanol consumption may be potentially beneficial for other auto-immune diseases.
Xu
Xiaomeng
X
Department of Oral Prophylaxis and Hygiene, Wenzhou Stomatology Hospital, Wenzhou Medical College, No. 113, West Xueyuan Road, Wenzhou City, Zhejiang 325027, China. hsu.bodhi@gmail.com
Chen
Donghui
D
Mei
Liqin
L
Deng
Hui
H
D000284:Administration, Oral; D000428:Alcohol Drinking; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D017676:Lichen Planus, Oral / Q000276:immunology* / Q000517:prevention & control*; D008954:Models, Biological
D000431:Ethanol