On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors.
Miyazaki
Isao
I
Antibiotics Laboratory and Chemical Biology Department, RIKEN, Wako, Saitama 351-0198, Japan.
Simizu
Siro
S
Ishida
Keisuke
K
Osada
Hiroyuki
H
D002460:Cell Line; D055808:Drug Discovery; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D015394:Molecular Structure; D010446:Peptide Fragments / Q000737:chemistry / Q000378:metabolism*; D040081:Protein Array Analysis / Q000295:instrumentation / Q000379:methods; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D016559:Tacrolimus / Q000737:chemistry / Q000378:metabolism; D022061:Tacrolimus Binding Protein 1A / Q000235:genetics / Q000378:metabolism
D007166:Immunosuppressive Agents; D008024:Ligands; D010446:Peptide Fragments; D011506:Proteins; D022061:Tacrolimus Binding Protein 1A; D016559:Tacrolimus