title: Antifungal susceptibility of 95 yeast strains isolated from oral mycoses in HIV-negative and HIV-positive patients.
abstract: The aim of this study is to evaluate the susceptibility profile to many antifungal drugs of 95 yeast strains isolated from oral mycoses in HIV-negative and HIV-positive patients from the eastern region of Romania. The antifungal drugs tested against all strains were 5-flucytosine (5FC), amphotericin B (AMB), fluconazole (FCA) and itraconazole (ITR), using ATB fungus2 devices (bioMérieux, France). For strains isolated from HIV-positive patients, two new antifungals were tested--voriconazole (VOR) and caspofungine (CAS), using Etest strips. The significance of results (MIC values) has been evaluated according to EUCAST and CLSI recommendations. The percent of resistance varied as follow: 6.31% for 5FC, 0% for AMB, 10.52% for FCA, 20% for ITR, 0% for VOR and O% for CAS. We can observe that all strains isolated from HIV-positive patients are susceptible to VOR and CAS--new antifungal molecules recently marketed. Also, the percent of resistance to current azoles (especially ITR) is relatively high.
authors.affiliation: University "Petre Andrei", Faculty of Dental Medicine, Department of Prosthodontics, Iaşi.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Mareş
authors.forename: Mihai
authors.initials: M
authors.lastname: Mareş
authors.forename: Mircea
authors.initials: M
authors.lastname: Rusu
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000382:microbiology*; D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics; D002180:Candidiasis, Oral / Q000188:drug therapy*; D000077336:Caspofungin; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology; D015725:Fluconazole / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000494:pharmacology; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests; D017410:Practice Guidelines as Topic; D011743:Pyrimidines / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine; D000077336:Caspofungin; D065819:Voriconazole