title: Outcomes of therapeutic deep lamellar keratoplasty and penetrating keratoplasty for advanced infectious keratitis: a comparative study.
abstract: OBJECTIVE
  To compare the therapeutic success, visual outcomes, complications, and graft survival rates of therapeutic deep anterior lamellar keratoplasty (TDALK) and therapeutic penetrating keratoplasty (TPK) for advanced infectious keratitis.
  
  
  METHODS
  Retrospective, comparative study.
  
  
  METHODS
  One hundred twenty-three patients (126 eyes) with medically uncontrolled infectious keratitis of bacterial, fungal, or acanthamoeba etiologies who underwent TDALK (n = 26) or TPK (n = 100 eyes; 80 nonperforated ulcers; 20 perforated ulcers; mean follow-up in TDALK, 12.9 months; in TPK, 21.3 months).
  
  
  METHODS
  We performed TDALK for infections confined to the corneal stroma and the technique used was either manual lamellar dissection or Anwar's big bubble technique for total stromal removal. Therapeutic penetrating keratoplasty was performed for either nonperforated or perforated ulcers. Comparison with respect to recurrence of infection, visual acuity, graft survival, and complications was made. Baseline characteristics of the patients were analyzed using the chi-square test. Kaplan-Meier survival analysis was used to evaluate graft survival.
  
  
  METHODS
  Therapeutic success (eradication of infection) or therapeutic failure (recurrence of original infection in cornea or sclera, or as endophthalmitis), graft survival (clarity), and best-corrected visual acuity (BCVA).
  
  
  RESULTS
  Therapeutic success rate of 84.6% was achieved in the TDALK group and 88% in the TPK group (P = 0.74); of the 12 eyes with recurrence of infection in the TPK cohort, 6 developed endophthalmitis with poor outcomes. A BCVA of > or =6/9 was achieved in 50% of patients in the TDALK group and 20.2% in the TPK group (P = 0.01). Mean improvement of acuity was 7.27 lines in the TDALK group and 4.76 lines in the TPK group (P = 0.01). Kaplan-Meier survival analysis at 1 year showed better graft survival for TDALK (90%) compared with TPK (78.4%).
  
  
  CONCLUSIONS
  For medically unresponsive infectious keratitis, TDALK may be considered instead of TPK yielding similar graft survival, without an increased risk of disease recurrence.
authors.affiliation: Singapore National Eye Centre, Singapore.
authors.forename: Arundhati
authors.initials: A
authors.lastname: Anshu
authors.forename: Anand
authors.initials: A
authors.lastname: Parthasarathy
authors.forename: Jodhbir S
authors.initials: JS
authors.lastname: Mehta
authors.forename: Hla Myint
authors.initials: HM
authors.lastname: Htoon
authors.forename: Donald T H
authors.initials: DT
authors.lastname: Tan
mesh_terms: D015823:Acanthamoeba Keratitis / Q000503:physiopathology / Q000601:surgery*; D000328:Adult; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000382:microbiology / Q000503:physiopathology / Q000601:surgery*; D015817:Eye Infections / Q000382:microbiology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006085:Graft Survival / Q000502:physiology; D006801:Humans; D007431:Intraoperative Complications; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012189:Retrospective Studies; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology*