Turmeric and green tea: a recipe for the treatment of B-chronic lymphocytic leukemia.
Two naturally occurring compounds, curcumin, the active ingredient in the spice turmeric, and the green tea extract epigallocatechin-3-gallate, have marked effects on the apoptotic machinery in chronic lymphocytic leukemia. These results provide a preclinical foundation for future clinical use of these compounds in this disease.
Angelo
Laura S
LS
Department of Investigational Cancer Therapeutics (Phase I Clinical Trials Program), Division of Cancer Medicine, M. D. Anderson Cancer Center, Houston, Texas 77030, USA. lsangelo@mdanderson.org
Kurzrock
Razelle
R
D017209:Apoptosis / Q000187:drug effects; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D030024:Curcuma; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy*; D013662:Tea
D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate; D003474:Curcumin