Thymic emigration: sphingosine-1-phosphate receptor-1-dependent models and beyond.
The thymus is a primary lymphoid organ supporting the development of self-tolerant T cells. Key events in T-cell development in the thymus include lineage commitment, selection events, and thymic emigration. This review discusses the proposed role of sphingosine-1-phosphate and its receptors in the emigration of both conventional and unconventional T-cell subsets from the thymus, and the molecular machinery currently understood to regulate this process. Furthermore, we highlight a role for chemokines and actin-associated proteins in T-cell motility as recent data suggest that T-cell emigration is regulated by more than just a sphingosine-1-phosphate receptor-1-dependent chemotactic axis.
Drennan
Michael B
MB
Department of Rheumatology, Ghent University Hospital, Ghent, Belgium.
Elewaut
Dirk
D
Hogquist
Kristin A
KA
D000818:Animals; D002465:Cell Movement / Q000276:immunology / Q000502:physiology*; D000068876:Fingolimod Hydrochloride; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000276:immunology / Q000378:metabolism*; D011409:Propylene Glycols / Q000494:pharmacology; D049349:Receptors, Lysosphingolipid / Q000819:agonists / Q000276:immunology / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000494:pharmacology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology* / Q000378:metabolism
D051741:Kruppel-Like Transcription Factors; D011409:Propylene Glycols; D049349:Receptors, Lysosphingolipid; D000068876:Fingolimod Hydrochloride; D013110:Sphingosine