title: Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking.
abstract: The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.
authors.affiliation: INSERM U862, NeuroCenter Magendie, Pathophysiology of Addiction, 147 Rue Léo Saignat, 33077 Bordeaux Cedex, France.
authors.forename: Frédéric
authors.initials: F
authors.lastname: Ambroggi
authors.forename: Marc
authors.initials: M
authors.lastname: Turiault
authors.forename: Aude
authors.initials: A
authors.lastname: Milet
authors.forename: Véronique
authors.initials: V
authors.lastname: Deroche-Gamonet
authors.forename: Sébastien
authors.initials: S
authors.lastname: Parnaudeau
authors.forename: Eric
authors.initials: E
authors.lastname: Balado
authors.forename: Jacques
authors.initials: J
authors.lastname: Barik
authors.forename: Rixt
authors.initials: R
authors.lastname: van der Veen
authors.forename: Grégoire
authors.initials: G
authors.lastname: Maroteaux
authors.forename: Thomas
authors.initials: T
authors.lastname: Lemberger
authors.forename: Günther
authors.initials: G
authors.lastname: Schütz
authors.forename: Monique
authors.initials: M
authors.lastname: Lazar
authors.forename: Michela
authors.initials: M
authors.lastname: Marinelli
authors.forename: Pier Vincenzo
authors.initials: PV
authors.lastname: Piazza
authors.forename: François
authors.initials: F
authors.lastname: Tronche
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D003042:Cocaine / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D019970:Cocaine-Related Disorders / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D012646:Self Administration; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism* / Q000523:psychology
chemical_list: C497713:NR3C1 protein, human; D017447:Receptors, Dopamine D1; D011965:Receptors, Glucocorticoid; D003042:Cocaine; D004298:Dopamine