Epithelial-specific requirement of FGFR2 signaling during tooth and palate development.
Reciprocal interactions between epithelium and mesenchyme are crucial for embryonic development. Fibroblast growth factors (FGFs) are a growth factor family that play an important role in epithelial-mesenchymal tissue interaction. We have generated epithelial-specific conditional knockout mice targeting Fibroblast growth factor receptor 2 (Fgfr2) to investigate the function of FGF signaling during craniofacial development. K14-Cre;Fgfr2(fl/fl) mice have skin defects, retarded tooth formation, and cleft palate. During the formation of the tooth primordium and palatal processes, cell proliferation in the epithelial cells of K14-Cre;Fgfr2(fl/fl) mice is reduced. Thus, FGF signaling via FGFR2 in the epithelium is crucial for cell proliferation activity during tooth and palate development.
Hosokawa
Ryoichi
R
Center for Craniofacial Molecular Biology, School of Dentistry, University of Southern California, Los Angeles, California 90033, USA.
Deng
Xuemei
X
Takamori
Kazunori
K
Xu
Xun
X
Urata
Mark
M
Bringas
Pablo
P
Chai
Yang
Y
D000818:Animals; D002972:Cleft Palate / Q000235:genetics; D004847:Epithelial Cells / Q000378:metabolism; D017403:In Situ Hybridization; D051379:Mice; D010159:Palate / Q000254:growth & development*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D014070:Tooth / Q000254:growth & development*
D051497:Receptor, Fibroblast Growth Factor, Type 2