title: Incidence and treatment results of laryngopharyngeal reflux in chronic obstructive pulmonary disease.
abstract: Laryngopharyngeal reflux (LPR) is defined as the movement of gastric content towards the larynx and the pharynx and it may cause respiratory symptoms or difficulty in their control. We aimed to find the frequency of LPR in chronic obstructive pulmonary disease (COPD) patients and to investigate its effect on COPD symptoms and the results of its treatment. At baseline 30 (20 male, 10 female, mean age: 65 +/- 10 years) COPD patients completed LPR and COPD symptom questionnaires and 13 (44%) were diagnosed with LPR based on laryngeal examination. Patients with LPR were given 2 months of PPI treatment, after which LPR and COPD symptom questionnaires, laryngeal examinations and pulmonary function tests were repeated. Following the treatment, significant improvements in COPD symptom index, LPR symptom index and laryngeal examination findings were observed in patients with LPR (P < 0.01, P < 0.01, P < 0.0001, respectively). Treatment of LPR resulted in a significant improvement in the symptoms of COPD.
authors.affiliation: Department of Pulmonary and Critical Care, Marmara University Hospital, Istanbul, Turkey. emeleryuksel@yahoo.com
authors.forename: Emel
authors.initials: E
authors.lastname: Eryuksel
authors.forename: Muzeyyen
authors.initials: M
authors.lastname: Dogan
authors.forename: Sehnaz
authors.initials: S
authors.lastname: Olgun
authors.forename: Ismail
authors.initials: I
authors.lastname: Kocak
authors.forename: Turgay
authors.initials: T
authors.lastname: Celikel
mesh_terms: D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D005764:Gastroesophageal Reflux / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D054328:Proton Pump Inhibitors / Q000627:therapeutic use*; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000503:physiopathology; D012008:Recurrence; D012189:Retrospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology
chemical_list: D054328:Proton Pump Inhibitors