title: [Effective gemcitabine plus S-1 treatment in elderly non-small cell lung cancer patients with multiple bone metastases].
abstract: An 81-year-old man presented with right shoulder pain 10 months after surgery for non-small cell lung cancer (p- T3N0M0, Stage II b). FDG-PET revealed an increased uptake in the multiple bone and mediastinal lymph nodes, suggestive of recurrence of lung cancer. He was given combined chemotherapy of gemcitabine plus S-1 as first-line treatment. This regimen was performed as a phase I trial for an elderly patient with advanced non-small cell lung cancer, and the treatment proved effective. No toxic events were observed due to this therapy, so he was treated as an outpatient for one year. He was considered to have good quality of life.
authors.affiliation: Dept. of Medicine and Molecular Science, Gunma University Graduate School of Medicine.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Kaira
authors.forename: Noriko
authors.initials: N
authors.lastname: Yanagitani
authors.forename: Noriaki
authors.initials: N
authors.lastname: Sunaga
authors.forename: Hisao
authors.initials: H
authors.lastname: Imai
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Utsugi
authors.forename: Tadayoshi
authors.initials: T
authors.lastname: Kawata
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hisada
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Shimizu
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Ishizuka
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy* / Q000556:secondary; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy* / Q000473:pathology; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010094:Oxonic Acid / Q000627:therapeutic use*; D049268:Positron-Emission Tomography; D005641:Tegafur / Q000627:therapeutic use*; D000093542:Gemcitabine
chemical_list: D004338:Drug Combinations; D003841:Deoxycytidine; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D000093542:Gemcitabine