Identifying protein-coding genes in genomic sequences.
The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets.
Harrow
Jennifer
J
Wellcome Trust Sanger Institute, Wellcome Trust Campus, Hinxton, Cambridge, UK.
Nagy
Alinda
A
Reymond
Alexandre
A
Alioto
Tyler
T
Patthy
Laszlo
L
Antonarakis
Stylianos E
SE
Guigó
Roderic
R
D000818:Animals; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D005796:Genes; D016678:Genome / Q000235:genetics*; D006801:Humans; D011506:Proteins / Q000235:genetics*
D011506:Proteins