[Multiple myeloma with variant type translocation, t(8;22)(q24;q11.2)].
A 68-year-old female complained of anemia and bone pain. Monoclonal increase of plasma IgA, lambda-type was observed, and immature plasma cells were detected in the bone marrow. These plasma cells showed intermediate differentiation on CD38 gating flow cytometry. Chromosomal analysis demonstrated complex abnormalities including repeats and translocation, t(8;22)(q24;q11.2) by G-banding, and breakpoint down stream of 3'c-MYC on fluorescence in situ hybridization. Multiple myeloma with variant type translocation was diagnosed. Treatment with continuous infusion of dexamethasone and oral administration of thalidomide effectively decreased IgA, plasma cells and chromosomal abnormality, facilitating complete remission.
Sugiyama
Akiko
A
Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center.
Nakabayashi
Hiroko
H
Kondo
Manabu
M
Tominaga
Takayuki
T
Shinohara
Kenji
K
D000284:Administration, Oral; D000368:Aged; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000235:genetics*; D012074:Remission Induction; D013792:Thalidomide / Q000008:administration & dosage; D014178:Translocation, Genetic / Q000235:genetics*
D013792:Thalidomide; D003907:Dexamethasone