Expression of cortactin and survivin in renal cell carcinoma associated with tumor aggressiveness.
OBJECTIVE
We tested the hypothesis that the expression of cortactin and survivin in renal cell carcinomas (RCCs) correlates with more advanced stages of the disease.


METHODS
Immunohistochemical analysis of cortactin and survivin expression (scored on a scale of 0-400) was performed in 124 renal cell carcinomas including clear cell renal cell carcinoma (CRCC), papillary RCC (PRCC), CRCC with sarcomatoid differentiation (SRCC), chromophobe RCC (ChRCC), and CRCC with granular cell differentiation (GRCC).


RESULTS
Higher cortactin scores in CRCC were significantly correlated with higher T (p = 0.021) and N stages (p = 0.036), and nuclear grade (p = 0.012). Higher cortactin immunostaining scores were associated with higher mortality (p = 0.035). In addition, the survivin scores were significantly higher in the more aggressive GRCC and SRCC than in CRCC, suggesting a significant role of survivin expression in transformation of tumor cells to a more malignant phenotype.


CONCLUSIONS
Higher expression of cortactin and survivin significantly correlated with advanced clinicopathological stage. Our findings support the potential targeting of survivin and cortactin for the development of novel therapeutic strategies for renal cell carcinoma.
Wang
Giueng-Chueng
GC
Department of Clinical Pathology, Tri-Service General Hospital and Taipei Medical University-Municipal Wan Fang Hospital, Taipei, Taiwan, ROC.
Hsieh
Po-Shiuan
PS
Hsu
Hsian-He
HH
Sun
Guang-Huan
GH
Nieh
Shin
S
Yu
Cheng-Ping
CP
Jin
Jong-Shiaw
JS
D014408:Biomarkers, Tumor; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D051356:Cortactin / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D046228:Microarray Analysis; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012720:Severity of Illness Index; D000077022:Survivin
C107489:BIRC5 protein, human; D014408:Biomarkers, Tumor; D051356:Cortactin; D051034:Inhibitor of Apoptosis Proteins; D008869:Microtubule-Associated Proteins; D000077022:Survivin