[P53 and its role in the ovarian surface epithelium. A review].
The ovarian surface epithelium (OSE) is a single layer of cells subject to a high rate of turnover at the site of follicular rupture at ovulation and this results in a higher risk of malignant cell transformation. Findings like cancer derived from OSE, that accounts for approximately 90% of all human ovarian malignancies and the frequent mutations of the p53 gen in most of them, are the basis for reviewing OSE structure and histogenesis related to p53, as well as some aspects associated with p53 stabilization and regulation, its involvement in key events like cell cycle arrest, induction of apoptosis, etiology and pathogenesis of epithelial ovarian cancer. Finally, this review takes into account recent farmacogeneticsadvances in order to use p53 as a target in the therapy against cancer.
Chuaire-Noack
Lilian
L
Departamento de Ciencias Básicas, Facultad de Medicina, Universidad del Rosario, Bogotá DC, Colombia. lchuaire@urosario.edu.co
Sánchez-Corredor
Magda Carolina
MC
Ramírez-Clavijo
Sandra
S
D002454:Cell Differentiation / Q000235:genetics; D049109:Cell Proliferation; D004848:Epithelium / Q000473:pathology; D005260:Female; D016158:Genes, p53 / Q000502:physiology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000235:genetics / Q000628:therapy; D010053:Ovary / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*
D016159:Tumor Suppressor Protein p53