Transition-metal-free intermolecular amination of sp3 C-H bonds with sulfonamides.
An efficient transition-metal-free intermolecular benzylic amidation with sulfonamides is described. Various valuable nitrogen-containing compounds, including amines, beta-chloro amine, amino alcohol, alpha-, beta-amino ester, and N-sulfonyl imine, are generated from the preferential N-functionalization of saturated benzylic C-H bonds. The potential of this reaction system also lies in the fact it can be developed into an environmentally friendly intermolecular amidation process.
Fan
Renhua
R
Department of Chemistry, Fudan University, 220 Handan Road, Shanghai, 200433, China. rhfan@fudan.edu.cn
Li
Weixun
W
Pu
Dongming
D
Zhang
Li
L