title: Psychotic disorders in Argentine patients with refractory temporal lobe epilepsy: a case-control study.
abstract: The issue of psychotic disorders in epilepsy has given rise to great controversy among professionals; however, there are not many studies in this area and the physiopathological mechanisms remain unknown. The aim of this study was to describe the spectrum of psychotic disorders in an Argentine population with refractory temporal lobe epilepsy (RTLE) and to determine the risk factors associated with psychotic disorders. Clinical variables of the epileptic syndrome were compared among a selected population with RTLE with and without psychotic disorders (DSM-IV/Ictal Classification of psychoses). Logistic regression was performed. Sixty-three patients with psychotic disorders (Psychotic Group, PG) and 60 controls (Control Group, CG) were included. The most frequent psychotic disorders were brief psychotic episodes (35%) (DSM-IV) and interictal psychosis (50%) (Ictal Classification). Risk factors for psychotic disorders were bilateral hippocampal sclerosis, history of status epilepticus, and duration of epilepsy greater than 20 years.
authors.affiliation: Epilepsy Center, Ramos Mejía Hospital, Buenos Aires, Argentina. ldalessio@intramed.net.ar
authors.forename: Luciana
authors.initials: L
authors.lastname: D'Alessio
authors.forename: Brenda
authors.initials: B
authors.lastname: Giagante
authors.forename: Cristina
authors.initials: C
authors.lastname: Papayannis
authors.forename: Silvia
authors.initials: S
authors.lastname: Oddo
authors.forename: Walter
authors.initials: W
authors.lastname: Silva
authors.forename: Patricia
authors.initials: P
authors.lastname: Solís
authors.forename: Vicente
authors.initials: V
authors.lastname: Donnoli
authors.forename: Marcelo
authors.initials: M
authors.lastname: Kauffman
authors.forename: Damián
authors.initials: D
authors.lastname: Consalvo
authors.forename: Luis María
authors.initials: LM
authors.lastname: Zieher
authors.forename: Silvia
authors.initials: S
authors.lastname: Kochen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001118:Argentina / Q000453:epidemiology; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D055815:Young Adult