title: Grade of adiposity affects the impact of fat mass on resting energy  expenditure in women.
abstract: Body fat mass (FM) adds to the variance in resting energy expenditure (REE). However, the nature and extent of this relationship remains unclear. Using a database of 1306 women and a linear regression model, we systematically analysed the contribution of FM to the total variance in REE at different grades of adiposity (ranges of body %FM). After adjusting for age, the relative contribution of FM on REE variance increased from low (<or= 10 %FM) to normal (>10- <or= 30 %FM) and moderately elevated (>30- <or= 40 %FM) grades of adiposity but decreased sharply at high (>40- # 50 %FM) and very high (>50 %FM) grades of adiposity according to the ratio between regression coefficients. These data suggest that the specific metabolic rate of fat tissue is reduced at high adiposity. This should be considered when REE is normalized for FM in obesity.
authors.affiliation: Institut für Humanernährung und Lebensmittelkunde, Agrar- und Ernährungswissenschaftliche Fakultät, Christian-Albrechts-Universität zu Kiel, Düsternbrooker Weg 17-19, D-24105 Kiel, Germany. abosyw@nutrfoodsc.uni-kiel.de
authors.forename: Anja
authors.initials: A
authors.lastname: Bosy-Westphal
authors.forename: Manfred J
authors.initials: MJ
authors.lastname: Müller
authors.forename: Michael
authors.initials: M
authors.lastname: Boschmann
authors.forename: Susanne
authors.initials: S
authors.lastname: Klaus
authors.forename: Georg
authors.initials: G
authors.lastname: Kreymann
authors.forename: Petra M
authors.initials: PM
authors.lastname: Lührmann
authors.forename: Monika
authors.initials: M
authors.lastname: Neuhäuser-Berthold
authors.forename: Rudolf
authors.initials: R
authors.lastname: Noack
authors.forename: Karl M
authors.initials: KM
authors.lastname: Pirke
authors.forename: Petra
authors.initials: P
authors.lastname: Platte
authors.forename: Oliver
authors.initials: O
authors.lastname: Selberg
authors.forename: Jochen
authors.initials: J
authors.lastname: Steiniger
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D050154:Adiposity / Q000502:physiology*; D000328:Adult; D000375:Aging / Q000502:physiology; D001481:Basal Metabolism / Q000502:physiology*; D001823:Body Composition; D002153:Calorimetry, Indirect; D017097:Electric Impedance; D004734:Energy Metabolism / Q000502:physiology; D005260:Female; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism*