title: Immunoprotection by polyethylene glycol in organ preservation solutions is not due to an immunomasking effect.
abstract: BACKGROUND
  New organ preservation solutions that contain soluble polyethylene glycol (sPEG) molecules have been associated with reduction of acute rejection episodes.
  
  
  METHODS
  In the present manuscript we tested in vitro whether sPEG molecules were able to mask donor alloantigens and reduce graft immunogenicity.
  
  
  RESULTS
  Immunomasking effect was only evidenced when PEG molecules were covalently bound to donor cell surface.
  
  
  CONCLUSIONS
  We concluded that sPEG in preservation solution are unlikely to display 'immunocamouflage' property.
authors.affiliation: INSERM, U851, 21 Avenue Tony Garnier, Lyon, F-69007, France. helene.perrin@inserm.fr
authors.forename: Hélène
authors.initials: H
authors.lastname: Perrin
authors.forename: Olivier
authors.initials: O
authors.lastname: Thaunat
authors.forename: Christophe
authors.initials: C
authors.lastname: Malcus
authors.forename: Lionel
authors.initials: L
authors.lastname: Badet
authors.forename: Ana
authors.initials: A
authors.lastname: Hennino
authors.forename: Ricardo
authors.initials: R
authors.lastname: Codas
authors.forename: Françoise
authors.initials: F
authors.lastname: Touraine-Moulin
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Nicolas
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Morelon
mesh_terms: D000954:Antigens, Surface / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D009926:Organ Preservation / Q000379:methods; D019188:Organ Preservation Solutions / Q000494:pharmacology / Q000627:therapeutic use*; D016377:Organ Transplantation / Q000379:methods; D011092:Polyethylene Glycols / Q000494:pharmacology / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
chemical_list: D000954:Antigens, Surface; D019188:Organ Preservation Solutions; D011092:Polyethylene Glycols