title: Late-life body mass index and waist circumference in amnestic mild cognitive impairment and Alzheimer's disease.
abstract: We investigated the progressive associations of late-life body mass index (BMI) and waist circumference (WC) with amnestic mild cognitive impairment (aMCI) and Alzheimer's disease (AD) in Chinese older adults in a case-control study. Late-life BMI and WC were measured. AD was diagnosed by the NINCDS-ADRDA criteria for probable AD and aMCI by the Petersen's criteria. 426 Chinese older adults [125 AD, 125 aMCI and 176 controls with normal cognition (NC)], aged 55 to 93 years old, were recruited. Both BMI and WC decreased significantly across the normal, aMCI, and AD groups (dementia diagnostic group: p for trend < 0.001 and 0.016 respectively, 1-way ANOVA). After adjustment for significant confounders, multivariate general linear model analyses showed that the dementia diagnostic group (AD/aMCI/NC) was a significant independent predictor of both the late-life BMI and late-life WC (p = 0.002 and 0.018 respectively). In conclusion, late-life BMI and WC progressively decrease in older adults with normal cognition, aMCI, and AD. Low late-life BMI and WC represent potentially useful pre-clinical markers of aMCI and AD.
authors.affiliation: Division of Geriatric Medicine, Department of Medicine, Queen Mary Hospital, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR. lwchu@hkucc.hku.hk
authors.forename: Leung-Wing
authors.initials: LW
authors.lastname: Chu
authors.forename: Sidney
authors.initials: S
authors.lastname: Tam
authors.forename: Peter W H
authors.initials: PW
authors.lastname: Lee
authors.forename: Ping-Yiu
authors.initials: PY
authors.lastname: Yik
authors.forename: Youqiang
authors.initials: Y
authors.lastname: Song
authors.forename: Bernard M Y
authors.initials: BM
authors.lastname: Cheung
authors.forename: Karen S L
authors.initials: KS
authors.lastname: Lam
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology*; D000704:Analysis of Variance; D053327:Apolipoprotein E4 / Q000235:genetics; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000235:genetics / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D055105:Waist Circumference / Q000502:physiology*
chemical_list: D053327:Apolipoprotein E4