title: Association of circulating adhesion molecules with lung function. The CARDIA study.
abstract: BACKGROUND
  Systemic inflammation has been associated with reduced lung function. Adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and P-selectin, figure importantly in initiating the inflammatory response. We studied the association between ICAM-1 and P-selectin concentrations and lung function in the Coronary Artery Risk Development in Young Adults study.
  
  
  METHODS
  Spirometry testing was conducted at years 5, 10, and 20. ICAM-1 and P-selectin were assayed at year 15.
  
  
  RESULTS
  Complete data were obtained from 2,455 participants. We first predicted year-20 lung function from year-15 ICAM-1 concentration data. After controlling for race, gender, height, age, physical activity, smoking status, alcohol intake, BMI, and asthma status, all taken at year 15, the year-20 FVC was 164 mL higher (p < 0.0001) and FEV(1) was 164 mL higher (p = 0.0003) in the lowest ICAM-1 concentration quartile than the highest ICAM-1 quartile, whereas the FEV(1)/FVC ratio showed no association (p = 0.25). We then predicted the year-15 ICAM-1 concentration from year-5 lung function and change in lung function (year 10 - year 5). The year-15 ICAM-1 concentration was about 13 ng/mL higher in the lowest vs highest quartile of either the year-5 FVC (p = 0.01) or year-5 FEV(1) (p = 0.005). Year-15 ICAM-1 concentration was unrelated to year-5 FEV(1)/FVC ratio. Greater loss in FVC and FEV(1) (year 10 - year 5) also was associated with higher year-15 ICAM-1 concentrations. Associations between P-selectin and lung function followed a similar but weaker pattern to that observed for ICAM-1.
  
  
  CONCLUSIONS
  These data suggest a bidirectional association between circulating adhesion molecules, such as ICAM-1 and P-selectin, and pattern of lung function change in adults.
authors.affiliation: Department of Laboratory Medicine and Pathology, Medical School, Minneapolis, MN.
authors.forename: Bharat
authors.initials: B
authors.lastname: Thyagarajan
authors.affiliation: Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors.forename: Lewis J
authors.initials: LJ
authors.lastname: Smith
authors.affiliation: Department of Medicine, Columbia University, New York, NY.
authors.forename: R Graham
authors.initials: RG
authors.lastname: Barr
authors.affiliation: Department of Laboratory Medicine and Pathology, Medical School, Minneapolis, MN.
authors.forename: Myron D
authors.initials: MD
authors.lastname: Gross
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of New Mexico, Albuquerque, NM.
authors.forename: Akshay
authors.initials: A
authors.lastname: Sood
authors.affiliation: Division of Pulmonary and Critical Care, Northwestern University Feinberg School of Medicine, Chicago, IL.
authors.forename: Ravi
authors.initials: R
authors.lastname: Kalhan
authors.affiliation: Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN; Department of Nutrition, University of Oslo, Oslo, Norway. Electronic address: jacobs@epi.umn.edu.
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008171:Lung Diseases / Q000097:blood / Q000503:physiopathology*; D008297:Male; D019007:P-Selectin / Q000097:blood*; D011237:Predictive Value of Tests; D012042:Registries; D012129:Respiratory Function Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D018836:Inflammation Mediators; D019007:P-Selectin; D018799:Intercellular Adhesion Molecule-1