Cytokinesis: GAP gap.
The central spindle regulates cleavage furrow formation and cytokinesis and is composed of antiparallel microtubules bundled by microtubule-associated proteins and kinesin motors. One key protein in the central spindle is a Rho family GTPase-activating protein, CYK-4/MgcRacGAP, whose target is the subject of two new studies that arrive at divergent models.
Glotzer
Michael
M
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA. mglotzer@uchicago.edu
D000818:Animals; D048749:Cytokinesis / Q000502:physiology*; D020690:GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D010641:Phenotype; D015398:Signal Transduction / Q000502:physiology; D008941:Spindle Apparatus / Q000378:metabolism*
D020690:GTPase-Activating Proteins; C115995:mgcRacGAP; C085379:rho GTPase-activating protein