Effectiveness of tacrolimus in high-risk limbal allo-graft transplantation.
We evaluated the efficacy and safety of tacrolimus in prevention of allograft rejection in high-risk allo-limbal grafts. Six eyes of six patients with severe limbal stem cell deficiency were included. All patients were started 0.1 mg x kg 1 x day(-1) tacrolimus orally 3 days before the surgery. Limbal allo-graft transplantation for ocular surface reconstruction had a successful outcome with using systemic tacrolimus for immunosuppression.
Yalçindag
F Nilüfer
FN
Ankara University Faculty of Medicine, Ophthalmology Department, Ankara, Turkey. yalcinda@medicine.ankara.edu.tr
Incel
Osman
O
Ozdemir
Ozden
O
D000328:Adult; D003316:Corneal Diseases / Q000601:surgery*; D004847:Epithelial Cells / Q000637:transplantation; D019573:Epithelium, Corneal / Q000637:transplantation*; D005260:Female; D006084:Graft Rejection / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D016850:Limbus Corneae / Q000166:cytology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D033581:Stem Cell Transplantation; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use*; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014792:Visual Acuity
D007166:Immunosuppressive Agents; D016559:Tacrolimus