Is a boosting dose of granulocyte-colony-stimulating factor necessary for healthy PBSC donors undergoing secondary apheresis? An institute's experience.
Successful allogeneic PBSC transplantation depends upon the infusion of an adequate number of CD34+ cells to patients. Granulocyte-colony-stimulating factors (G-CSF) mobilized PBSC were harvested on 5th day after stimulation from donors. When the CD34+ cell target yield was not achieved; secondary apheresis was performed the following day. Before September 2006, 67 donors (Group A) received five doses of G-CSF. After September 2006, a sixth dose of G-CSF was administered to 35 donors (Group B) to improve CD34+ yield. The mean CD34+-cell concentration of the second PBSC harvest was significantly higher in Group B (1,087 x 10(6)/l vs. 767 x 10(6)/l; P = 0.031).
Chen
Shu-Huey
SH
Department of Paediatrics, Hualien Tzu-Chi Hospital, Hualien 970, Taiwan. sshhuu.chen@msa.hinet.net
Lu
Chi-Jui
CJ
Wen
Shu-Hui
SH
Zheng
Ya-Jun
YJ
Yang
Shang-Hsien
SH
Su
Yu-Chieh
YC
Li
Dian-Kun
DK
D000328:Adult; D053687:Adult Stem Cells / Q000187:drug effects*; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D004334:Drug Administration Schedule; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007937:Leukapheresis / Q000379:methods*; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D011994:Recombinant Proteins; D012189:Retrospective Studies
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim