[Therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats].
OBJECTIVE
To study the therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats.


METHODS
The rats bearing implanted Walker-256 hepatoma were treated with high-dose vitamin C at 2.83 and 5.65 g/kg intravenously, and the general condition, liver functions (A/G, ALT, AST, GGT), tumor volume, and tumor growth of the rats were evaluated.


RESULTS
The A/G of the rats treated with 2.83 g/kg vitamin C was significantly higher, but the ALT and GCT were significantly lower than those of the model rats (P<0.05 or 0.01). The ALT level in rats with 5.65 g/kg vitamin C treatment was significantly lower than that of the model rats (P<0.05). The tumor necrosis rate was significantly higher in rats with 2.83 g/kg vitamin C treatment than in the model rats (P<0.05).


CONCLUSIONS
Intravenous administration of 2.83 g/kg vitamin C can promote the necrosis and apoptosis of hepatoma Walker256 cells in rats and protect the liver function of the tumor-bearing rats.
Peng
Lin-ji
LJ
Department of Pathophysiology, Medical College of Jinan University, and Clifforo Hospital, Guangzhou 510632, China. 13798054571zt@163.com
Lu
Da-xiang
DX
Qi
Ren-bin
RB
Zhang
Tao
T
Wang
Zhen
Z
Sun
Yong
Y
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009336:Necrosis; D009368:Neoplasm Transplantation; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D001205:Ascorbic Acid