Role of adrenergic alpha-2-receptors on feeding behavior in layer-type chicks.
The present study was designed to investigate the role of brain adrenergic alpha-2-receptors on feeding regulation of layer-type chicks. Intracerebroventricular injection of the adrenergic alpha-2-receptor agonist, clonidine, stimulated food intake. This effect was blocked by co-injection of the alpha-2-receptor antagonist, yohimbine, demonstrating that the alpha-2-receptor is related to stimulation of feeding in layer-type chicks. Stimulation of food intake caused by neuropeptide Y and beta-endorphin was attenuated by co-injection with yohimbine. However, yohimbine did not block prolactin-releasing peptide stimulation of food intake. It is therefore likely that brain adrenergic alpha-2-receptors mediate the orexigenic effects of neuropeptide Y and beta-endorphin in layer-type chicks.
Tachibana
Tetsuya
T
Laboratory of Animal Production, Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Tarumi 3-5-7, Matsuyama 790-8566, Japan. tetsu@agr.ehime-u.ac.jp
Sugahara
Kunio
K
Ueda
Hiroshi
H
Cline
Mark A
MA
D058647:Adrenergic alpha-2 Receptor Agonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D002645:Chickens / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology; D004435:Eating / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009478:Neuropeptide Y / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*; D015016:Yohimbine / Q000494:pharmacology; D001615:beta-Endorphin / Q000494:pharmacology
D058647:Adrenergic alpha-2 Receptor Agonists; D058669:Adrenergic alpha-2 Receptor Antagonists; D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D009478:Neuropeptide Y; D018377:Neurotransmitter Agents; D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine; D001615:beta-Endorphin; D003000:Clonidine