Imaging T-cell movement in the brain during experimental cerebral malaria.
T-cells are known to play a role in the pathology associated with experimental cerebral malaria, although it has not previously been possible to examine their behaviour in brain. Using multiphoton laser scanning microscopy, we have examined the migration and movement of these cells in brain tissue. We believe that this approach will help define host-parasite interactions and examine how intervening in these relationships affects the development of cerebral pathology.
Ortolano
F
F
Centre for Biophotonics, University of Strathclyde, Glasgow, UK.
Maffia
P
P
Dever
G
G
Hutchison
S
S
Benson
R
R
Millington
O R
OR
De Simoni
M G
MG
Bushell
T J
TJ
Garside
P
P
Carswell
H V
HV
Brewer
J M
JM
D000818:Animals; D001921:Brain / Q000276:immunology* / Q000473:pathology*; D002465:Cell Movement / Q000276:immunology*; D016779:Malaria, Cerebral / Q000276:immunology* / Q000473:pathology*; D051379:Mice; D018613:Microscopy, Confocal / Q000379:methods*; D013601:T-Lymphocytes / Q000276:immunology*