Current trends and challenges in MRI acquisitions to investigate brain function.
Functional magnetic resonance imaging (fMRI) studies using the blood oxygenation level dependent (BOLD) response have become a widely used tool for noninvasive assessment of functional organization of the brain. Yet the technique is still fairly new, with many significant challenges remaining. Capitalizing on additional contrast mechanisms available with MRI, several other functional imaging techniques have been developed that potentially provide improved quantification or specificity of neuronal function. This article reviews the challenges and the current state of the art in MRI-based methods of imaging cognitive function.
Sutton
Bradley P
BP
Bioengineering Department, University of Illinois at Urbana-Champaign, 3120 DCL, 1304 W Springfield Avenue, Urbana, IL 61801 United States. bsutton@illinois.edu
Ouyang
Cheng
C
Karampinos
Dimitrios C
DC
Miller
Gregory A
GA
D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D001931:Brain Mapping; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods / Q000639:trends; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000639:trends; D010100:Oxygen / Q000097:blood*
D003287:Contrast Media; D010100:Oxygen