title: Periumbilical purpura prior to gastrointestinal involvement in Henoch-Schönlein purpura.
abstract: Henoch-Schönlein purpura (HSP) is a systemic vasculitis involving the skin, joints, gastrointestinal tract, and kidneys. While HSP is traditionally considered a disease of children, it also occurs in adults. In both populations, acute gastrointestinal complications and chronic renal involvement are major predictors of mortality. While it has been previously demonstrated that truncal lesions in HSP are associated with underlying renal involvement, a significant proportion of cases with gastrointestinal involvement also have associated truncal lesions. It is unclear at this time whether or not the association of truncal involvement with visceral disease is related to an increased burden of circulating immune complexes or a more specific mechanism. We describe a report of periumbilical purpura antecedent to gastrointestinal involvement in an adult with HSP.
authors.affiliation: Department of Dermatology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Brown
authors.forename: Justin M
authors.initials: JM
authors.lastname: Haught
authors.forename: Joseph C
authors.initials: JC
authors.lastname: English
mesh_terms: D006471:Gastrointestinal Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012867:Skin / Q000276:immunology / Q000473:pathology; D014057:Tomography, X-Ray Computed; D014472:Umbilicus / Q000473:pathology
chemical_list: D005938:Glucocorticoids; D011241:Prednisone; D008775:Methylprednisolone