Diagnosis and treatment in inflammatory neuropathies.
The inflammatory neuropathies are a large diverse group of immune-mediated neuropathies that are amenable to treatment and may be reversible. Their accurate diagnosis is essential for informing the patient of the likely course and prognosis of the disease, informing the treating physician of the appropriate therapy and informing the scientific community of the results of well-targeted, designed and performed clinical trials. With the advent of biological therapies able to manipulate the immune response more specifically, an understanding of the pathogenesis of these conditions is increasingly important. This review presents a broad overview of the pathogenesis, diagnosis and therapy of inflammatory neuropathies, concentrating on the most commonly encountered conditions.
Lunn
M P T
MP
Centre for Neuromuscular Disease and Department of Molecular Neuroscience, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK. michael.lunn@uclh.org
Willison
H J
HJ
D003240:Connective Tissue Diseases / Q000175:diagnosis / Q000628:therapy; D003937:Diagnosis, Differential; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000628:therapy; D006801:Humans; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000628:therapy; D009460:Neurologic Examination; D010265:Paraproteinemias / Q000175:diagnosis / Q000628:therapy; D011129:Polyradiculoneuropathy / Q000175:diagnosis* / Q000628:therapy; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis* / Q000628:therapy; D011379:Prognosis; D014657:Vasculitis / Q000175:diagnosis / Q000628:therapy