Effect of sildenafil on wound healing: an experimental study.
OBJECTIVE
We aimed to investigate the effect of sildenafil on the healing process of abdominal wall wound in rats.


METHODS
The study was performed with adult female Wistar-Albino rats. Control group (n = 50) were fed on standard laboratory diet until 12 h before surgery. Study group (n = 50) were applied orally with orogastric tube 10 mg/kg once a day for 10 days of sildenafil therapy. Each rat was anesthetized, and a 4-cm-long midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 4, 7, 14, 21, and 35. Breaking strength analysis was measured, and the abdominal incision wounds were examined histologically.


RESULTS
Breaking strength for the midline incision, acute inflammation score on POD 14, and neovascularization on PODs 7, 14, 21, and 35 were significantly higher in the study group.


CONCLUSIONS
Sildenafil can be used as a supporting factor in wound healing.
Derici
Hayrullah
H
hayrullahderici@yahoo.com
Kamer
Erdinç
E
Unalp
Haluk Recai
HR
Diniz
Gulden
G
Bozdag
Ali Dogan
AD
Tansug
Tugrul
T
Ortac
Ragip
R
Erbil
Yesim
Y
D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D005260:Female; D006909:Hydroxyproline / Q000032:analysis; D007813:Laparotomy; D023421:Models, Animal; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology*; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D006909:Hydroxyproline