title: Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies.
abstract: Neonatal thrombocytopenia or neutropenia may result from passive transfusion of maternally derived antibodies. Antibodies against platelet antigens are commonly associated with neonatal alloimmune thrombocytopenia (NAIT), and anti-neutrophil antibodies are frequently identified in alloimmune neonatal neutropenia (ANN). Combined alloimmune cytopenias in the newborn are rarely reported; even fewer reports document human leukocyte antigen (HLA) antibodies as a potential cause of neonatal thrombocytopenia or neutropenia. We describe neutropenia and thrombocytopenia in a newborn associated with markedly elevated maternal HLA antibodies in the absence of anti-neutrophil or anti-platelet antibodies to highlight consideration of HLA antibodies in the pathogenesis of ANN and NAIT.
authors.affiliation: Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94107, USA.
authors.forename: M Monica
authors.initials: MM
authors.lastname: Gramatges
authors.forename: Pauline
authors.initials: P
authors.lastname: Fani
authors.forename: Kari
authors.initials: K
authors.lastname: Nadeau
authors.forename: Shalini
authors.initials: S
authors.lastname: Pereira
authors.forename: Michael R
authors.initials: MR
authors.lastname: Jeng
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D009503:Neutropenia / Q000151:congenital* / Q000276:immunology*; D011247:Pregnancy; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000276:immunology*
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D006680:HLA Antigens; D007518:Isoantibodies