[Testosterone metabolism and doping test results].
Glucuronidation is one of the most important metabolic processes which eliminates androgens from the human organism. Three enzymes (UDP-glucuronosyltransferases) are responsible for transfering the glucuronic group from glucuronic acid to androgens: UGT2B7, UGT2B15 and UGT2B17. Glucuronide products are more polar, water soluble, less toxic and easily extracted form the body. Testosterone is a common androgen abused in sport. The norm for urinary testosterone/epitestosterone ratio is below 4.0. Large testosterone excretion is associated with a deletion polymorphism of the UGT2B17 gene. This polymorphism decreases T/E ratio level.
Laczmański
Łukasz
Ł
Katedra i Klinika Endokrynologii, Diabetologii i Leczenia Izotopami, Akademia Medyczna im. Piastów Slaskich, Wrocław. laczman@endo.am.wroc.pl
Medraś
Marek
M
D000818:Animals; D004300:Doping in Sports; D004845:Epitestosterone / Q000378:metabolism; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D008660:Metabolism; D015778:Minor Histocompatibility Antigens; D011110:Polymorphism, Genetic; D017384:Sequence Deletion; D019966:Substance-Related Disorders / Q000235:genetics* / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology* / Q000652:urine*
D015778:Minor Histocompatibility Antigens; D013739:Testosterone; D004845:Epitestosterone; D014453:Glucuronosyltransferase; C500513:UGT2B17 protein, human