Spectrophotometric determination of ketoprofen and its application in pharmaceutical analysis.
A new simple rapid and sensitive spectrophotometric method has been developed for the determination of ketoprofen in pharmaceutical preparations. The method is based on the reaction of ketoprofen with an analytical reagent--Astra Phloxin FF--at pH 8.0-10.8 and followed by the extraction of formed ion associate in toluene with spectrophotometric detection (it has an absorption maximum at 563 nm, epsilon = 7.6 x 10(4) L x mol(-1) x cm(-1)). The calibration plot was linear from 0.8-16.0 microg x mL(-1) of ketoprofen, and the detection limit was 0.037 microg x mL(-1).
Kormosh
Zholt
Z
Department of Analytical Chemistry, Volyn National University, Lutsk, Ukraine. kormosh@univer.lutsk.ua
Hunka
Iryna
I
Basel
Yaroslav
Y
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D007660:Ketoprofen / Q000032:analysis*; D013053:Spectrophotometry / Q000379:methods*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D007660:Ketoprofen