[Plasmacytoid dendritic cells in pathophysiology of immune responses].
Plasmacytoid dendritic cells (pDC), so named because of histological similarities to antibody-producing plasma cells, comprise a unique dendritic cell population. Despite their low numbers in blood they play a key role in anti-viral immunity, mainly through secreting massive amounts of type 1 interferon following an engagement of their Toll-like receptors, such as TLR7 and TLR9, by viral nucleic acids. In a mature state, pDC display a propensity to present antigens to naive lymphocytes. Through their unique potential to rapidly and efficiently secrete type I interferon and serve as antigen presenting cells, pDC are currently considered as one of the major regulators of immune responses.
Kulig
Paulina
P
Zakład Immunologii, Wydział Biochemii, Biofizyki i Biotechnologii Uniwersytetu Jagiellońskiego, Kraków.
Wawro
Karolina
K
Cichy
Joanna
J
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007370:Interferon Type I / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors / Q000378:metabolism
D016207:Cytokines; D007370:Interferon Type I; D051193:Toll-Like Receptors