title: Sensitization of squamous cell carcinoma to cisplatin induced killing by natural agents.
abstract: Cisplatin resistance is a major problem in the successful treatment of squamous cell carcinoma (SCC). In the present study we showed, for the first time, that the constitutive activation of NF-kappaB partly contributes to cisplatin resistance and that the inactivation of NF-kappaB by natural agents [G2535 (isoflavone mixture containing genistein and diadzein), 3,3'-diindolylmethane (Bioresponse BR-DIM referred to as B-DIM)] could overcome this resistance, resulting in the inhibition of cell growth and induction of apoptosis, which might be an useful strategy for achieving better treatment outcome in patients diagnosed with cisplatin-resistant tumors of SCC.
authors.affiliation: Division of Hematology/Oncology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA.
authors.forename: Shadan
authors.initials: S
authors.lastname: Ali
authors.affiliation: Department of Pathology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA.
authors.forename: Lalee
authors.initials: L
authors.lastname: Varghese
authors.affiliation: Department of Otolaryngology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA.
authors.forename: Lucio
authors.initials: L
authors.lastname: Pereira
authors.affiliation: Department of Otolaryngology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA.
authors.forename: Ozlem E
authors.initials: OE
authors.lastname: Tulunay-Ugur
authors.affiliation: Division of Hematology/Oncology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA.
authors.forename: Omer
authors.initials: O
authors.lastname: Kucuk
authors.affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Carey
authors.affiliation: Department of Otolaryngology, University of Michigan, Ann Arbor, MI, USA.
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Wolf
authors.affiliation: Department of Pathology, Karmanos Cancer Center, Wayne State University, Detroit, MI, USA. Electronic address: fsarkar@med.wayne.edu.
authors.forename: Fazlul H
authors.initials: FH
authors.lastname: Sarkar
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D019833:Genistein / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D051034:Inhibitor of Apoptosis Proteins; D007529:Isoflavones / Q000494:pharmacology*; D008869:Microtubule-Associated Proteins / Q000235:genetics; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D000077022:Survivin; D051020:bcl-X Protein / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; C494811:BCL2L1 protein, human; C107489:BIRC5 protein, human; D007211:Indoles; D051034:Inhibitor of Apoptosis Proteins; D007529:Isoflavones; D008869:Microtubule-Associated Proteins; D016328:NF-kappa B; D019253:Proto-Oncogene Proteins c-bcl-2; D000077022:Survivin; D051020:bcl-X Protein; C004742:daidzein; D004247:DNA; D019833:Genistein; D002945:Cisplatin; C016392:3,3'-diindolylmethane