title: Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study.
abstract: OBJECTIVE
  To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and cardiometabolic risk factors.
  
  
  METHODS
  Participants from the Framingham Heart Study offspring cohort (n = 916, 55% women; mean age 59 years) free of cardiovascular disease underwent computed tomography measurement of visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), pericardial fat, and intrathoracic fat volumes and assays of circulating adiponectin and resistin.
  
  
  RESULTS
  VAT, SAT, pericardial fat, and intrathoracic fat were negatively correlated with adiponectin (r = -0.19 to -0.34, P < 0.001 [women]; r = -0.15 to -0.26, P < 0.01 [men] except SAT) and positively correlated with resistin (r = 0.16-0.21, P < 0.001 [women]; r = 0.11-0.14, P < 0.05 [men] except VAT). VAT increased the multivariable model R(2) for adiponectin from 2-4% to 10-13% and for resistin from 3-4% to 3-6%. Adjustment for adipokines did not fully attenuate associations between VAT, SAT, and cardiometabolic risk factors.
  
  
  CONCLUSIONS
  Adiponectin and resistin are correlated with fat depots cross-sectionally, but none of the adipokines can serve as surrogates for the fat depots. Relations between VAT, SAT, and cardiometabolic risk factors were not fully explained by adiponectin or resistin concentrations.
authors.affiliation: Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital, Boston, Massachusetts, USA.
authors.forename: Shilpa H
authors.initials: SH
authors.lastname: Jain
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Massaro
authors.forename: Udo
authors.initials: U
authors.lastname: Hoffmann
authors.forename: Guido A
authors.initials: GA
authors.lastname: Rosito
authors.forename: Ramachandran S
authors.initials: RS
authors.lastname: Vasan
authors.forename: Annaswamy
authors.initials: A
authors.lastname: Raji
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: O'Donnell
authors.forename: James B
authors.initials: JB
authors.lastname: Meigs
authors.forename: Caroline S
authors.initials: CS
authors.lastname: Fox
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology; D052242:Adiponectin / Q000097:blood*; D000368:Aged; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006331:Heart Diseases / Q000453:epidemiology*; D006801:Humans; D050152:Intra-Abdominal Fat / Q000033:anatomy & histology*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D052243:Resistin / Q000097:blood*; D050151:Subcutaneous Fat / Q000033:anatomy & histology*; D013909:Thorax / Q000033:anatomy & histology; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D052242:Adiponectin; D052243:Resistin; D014280:Triglycerides; D002784:Cholesterol