Kinase domain mutations in cancer: implications for small molecule drug design strategies.
Bikker
Jack A
JA
Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. bikkerj@wyeth.com
Brooijmans
Natasja
N
Wissner
Allan
A
Mansour
Tarek S
TS
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics*; D011487:Protein Conformation
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D010770:Phosphotransferases