title: Use of intraoperative insulin assay for the localisation of insulinoma.
abstract: BACKGROUND
  The curative treatment for patients with insulinoma is the surgical removal of the tumour; however, these tumours are small and therefore their preoperative localisation using ultrasound and CT scans may be difficult.
  
  
  METHODS
  Intraoperative serum insulin measurements were used as an aid to the surgical management of seven unselected and consecutive presentations of insulinoma.
  
  
  RESULTS
  In six of the seven cases we were able to demonstrate an increase in the peripheral serum insulin concentration between 3 and 5 min after manual examination of the tumour. In addition, there was a 50% decrease in concentration 10 min after removal of the tumour.
  
  
  CONCLUSIONS
  We believe that intraoperative insulin measurements are of use in demonstrating the functionality of tumours localised by intraoperative ultrasound and surgical examination. In addition, they act as an indicator of the completeness of surgery post tumour excision.
authors.affiliation: Department of Surgery, University Hospital of Wales, Heath Park, Cardiff CF14 4XW, Wales. scott.coombes@cardiffandvale.wales.nhs.uk
authors.forename: David
authors.initials: D
authors.lastname: Scott-Coombes
authors.forename: Fiona
authors.initials: F
authors.lastname: Eatock
authors.forename: Robert
authors.initials: R
authors.lastname: Henley
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Luzio
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007340:Insulinoma / Q000097:blood / Q000175:diagnosis / Q000601:surgery*; D007430:Intraoperative Care / Q000379:methods*; D010173:Palpation; D010190:Pancreatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000601:surgery*
chemical_list: D014408:Biomarkers, Tumor; D007328:Insulin