title: Effects of double and triple combinations of antifungal drugs in a murine model of disseminated infection by Scedosporium prolificans.
abstract: We have evaluated the efficacies of micafungin, amphotericin B, and voriconazole, alone and in double and triple combinations, in a murine model of systemic infection by Scedosporium prolificans. Micafungin combined with voriconazole or amphotericin B was the most effective, these being the only treatments able to prolong survival and to reduce the fungal load in the kidneys and brain. Triple combinations of these drugs did not improve the results obtained with double combinations.
authors.affiliation: Unitat de Microbiologia, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: M Mar
authors.initials: MM
authors.lastname: Rodríguez
authors.forename: Enrique
authors.initials: E
authors.lastname: Calvo
authors.forename: Carolina
authors.initials: C
authors.lastname: Serena
authors.forename: Marçal
authors.initials: M
authors.lastname: Mariné
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001921:Brain / Q000382:microbiology; D004195:Disease Models, Animal; D025141:Drug Resistance, Fungal; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000382:microbiology; D055666:Lipopeptides / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D000077551:Micafungin; D051379:Mice; D008826:Microbial Sensitivity Tests; D008271:Mycetoma / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use; D021681:Scedosporium / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole; D000077551:Micafungin