title: [Application of magnetic resonance imaging in evaluating the effects of manipulation on knee osteoarthritis].
abstract: OBJECTIVE
  To observe and evaluate the effects of manipulation on knee osteoarthritis (KOA) using T2-mapping and magnetic resonance imaging (MRI)-based volume measurements.
  
  
  METHODS
  Forty-five cases of KOA were involved retrospectively in the study, and the patients were composed of 9 males and 36 females with the mean age of (57.4+/-6.1) years. The cases were treated with manipulative therapy once or twice per week for 12 months. MRI of each knee was performed separately by using 1.5-T MRI equipment before and during the treatment. Average cartilage depth, MRI grading of cartilage defects, cartilage volume, average T2 values in patella cartilage and femoral condyle, and bone marrow edema area were detected respectively.
  
  
  RESULTS
  The knee joint cartilage thickness from MRI began to increase after 6-month treatment (P<0.05). The cartilage volume increase was obviously observed after 12-month treatment, and there was a significant difference (F=14.64, P<0.01). MRI grading of cartilage defects decreased from IIIA to IIB after 3-month treatment (Z=17.96, P<0.05). The average T2 value in patella cartilage decreased after 9-month treatment (F=3.11, P<0.05), but there were no differences in cartilage from tibial plateau and femoral condyle compartments after the treatment. The bone marrow edema area in femoral condyle began to diminish at 3-month treatment (t=-4.53, P<0.01), and the bone marrow edema area in cartilage patella was diminished after 6-month treatment (t=-5.53, P<0.01).
  
  
  CONCLUSIONS
  T2-mapping and cartilage volume measurement are suitable for evaluating the manipulative therapy on KOA. Traditional Chinese manipulation therapy is an effective method for KOA in the cartilage recovery.
authors.affiliation: Department of Traumatology, Ruijin Hospital, Medical College of Shanghai Jiaotong University, Shanghai 200025, China.
authors.forename: Jiong
authors.initials: J
authors.lastname: Hu
authors.forename: Ning
authors.initials: N
authors.lastname: DU
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
authors.forename: Ling-Hui
authors.initials: LH
authors.lastname: Dai
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D026201:Musculoskeletal Manipulations; D020370:Osteoarthritis, Knee / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome