The role of fibroblast growth factor-2 in healing the dura mater after inducing cerebrospinal fluid leakage in rats.
We conducted a study to determine the effectiveness of topically applied recombinant mouse fibroblast growth factor-2 (FGF-2) in healing the dura mater in a rat with dura mater injury and cerebrospinal fluid leakage. Laminectomies were performed in 32 rats at the level of the L2-L4 vertebrae, and a dura mater defect was created. Sixteen rats were treated postoperatively with locally applied recombinant mouse FGF-2, and 16 animals received normal saline. FGF-2 effects on dura mater healing, cerebrospinal fluid leakage, and wound healing were assessed at 3 and 6 weeks postoperatively. The extent of dura mater healing was evaluated by histological analysis. We found that dura mater healing was significantly increased (p<0.05) in rats treated with FGF-2 compared with rats in the control group. In this experimental model, locally applied FGF-2 effectively increased dura mater healing and induced no side effects.
Nurata
Hakan
H
Department of Neurosurgery, Ergani State Hospital, Ergani, Diyarbakir, Turkey.
Cemil
Berker
B
Kurt
Gökhan
G
Uçankuş
Neşe Lortlar
NL
Dogulu
Fikret
F
Omeroğlu
Suna
S
D000818:Animals; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004388:Dura Mater / Q000187:drug effects* / Q000293:injuries; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D005347:Fibroblasts / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013353:Subdural Effusion / Q000473:pathology* / Q000628:therapy*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D016222:Fibroblast Growth Factor 2