title: The type VI secretion system: a tubular story.
abstract: The molecular mechanism by which proteins are secreted in gram-negative bacteria is supported by nanomachines called type I to type VI secretion systems (T1SS to T6SS). Previous data suggested that the ClpV ATPase energizes the transport of Hcp and VgrG proteins through the T6SS secretion channel. The identification of a yet unknown tubular structure, which interacts with ClpV, adds another level of complexity and challenges our vision of the T6SS working model.
authors.affiliation: Division of Cell and Molecular Biology, Imperial College London, Centre for Molecular Microbiology and Infection, London, UK. a.filloux@imperial.ac.uk
authors.forename: Alain
authors.initials: A
authors.lastname: Filloux
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D001692:Biological Transport / Q000235:genetics; D002462:Cell Membrane / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial / Q000235:genetics; D006090:Gram-Negative Bacteria / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D021381:Protein Transport; D037521:Virulence Factors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors; D000251:Adenosine Triphosphatases