title: Multivalent protein binding and precipitation by self-assembling molecules on a DNA pentaplex scaffold.
abstract: A supramolecular assembly containing an isoguanosine pentaplex with both a "protein-binding" face and a "reporter" face has been generated. When phosphocholine is appended to the protein-binding face this supramolecular assembly binds multivalently to the pentameric human C-reactive protein, a biomolecule implicated in inflammation and heart disease.
authors.affiliation: Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 06511, USA.
authors.forename: Brooke A
authors.initials: BA
authors.lastname: Rosenzweig
authors.forename: Nathan T
authors.initials: NT
authors.lastname: Ross
authors.forename: Debarati M
authors.initials: DM
authors.lastname: Tagore
authors.forename: Janarthanan
authors.initials: J
authors.lastname: Jayawickramarajah
authors.forename: Ishu
authors.initials: I
authors.lastname: Saraogi
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D002097:C-Reactive Protein / Q000737:chemistry / Q000378:metabolism*; D002352:Carrier Proteins; D011232:Chemical Precipitation; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008027:Light; D010767:Phosphorylcholine / Q000737:chemistry* / Q000378:metabolism*; D012542:Scattering, Radiation
chemical_list: D002352:Carrier Proteins; D010767:Phosphorylcholine; D002097:C-Reactive Protein; D004247:DNA