title: MLL5 governs hematopoiesis: a step closer.
abstract: MLL5 is an MLL family protein and a candidate tumor suppressor located within the human chromosome band 7q22 that is frequently deleted in myeloid malignancies. In this issue of Blood, 3 independent studies report the first genetic analysis of MLL5 deficiency in mice. All 3 strains of MLL5 knockout mice exhibited defects in hematopoiesis, highlighting the critical role of MLL5 in hematopoietic stem cell functions.
authors.affiliation: Washington University, St Louis, MO, USA.
authors.forename: Han
authors.initials: H
authors.lastname: Liu
authors.forename: Todd D
authors.initials: TD
authors.lastname: Westergard
authors.forename: James J-D
authors.initials: JJ
authors.lastname: Hsieh