[Expression of Fas protein in myocardiac tissue of viral myocarditis and dilated cardiomyopathy].
OBJECTIVE
To study the pathogenesis of viral myocarditis (VMC) and dilated cardiomyopathy (DCM) and their relationship.


METHODS
Sixty samples including 20 VMC, 20 DCM and 20 controls were collected. The expression of Fas protein in myocardium of each group was detected by modified immunohistochemistry with unequivocal brown staining in the myocardial membrane scored as positive, and the results of positive reaction were analyzed by Ridit test.


RESULTS
Fas protein expression increased obviously in VMC and DCM groups as compared with that of the control group. The difference of positive results between each group analyzed by Ridit test was statistically significant (P<0.005). Statistically significant differences were found between VMC and control groups as well as between DCM and control groups (P<0.05), but not between VMC and DCM groups (P>0.05) by multiple comparison Ridit test.


CONCLUSIONS
The expression of Fas protein is significantly higher in the VMC and DCM groups than in that of the control group. These results suggest that both the VMC and DCM may share a similar pathogenesis, which most likely involves cell apoptosis.
Wu
Xiao-Qiao
XQ
The Third Department of Medicine, Wanan Medical College, Wuhu 241001, China. wxiaoqiao@yahoo.com.cn
Li
Yong-Hong
YH
Zhu
Xian
X
Wu
Mao-Wang
MW
Hu
Sheng-Ming
SM
D017209:Apoptosis / Q000502:physiology*; D002311:Cardiomyopathy, Dilated / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000378:metabolism* / Q000473:pathology / Q000821:virology*; D019014:fas Receptor / Q000235:genetics / Q000378:metabolism*
C491901:FAS protein, human; D019014:fas Receptor