title: Collision tumors of the sella: craniopharyngioma and silent pituitary adenoma subtype 3: case report.
abstract: Collision tumors of the sella turcica are rare and consist mainly of more than one type of pituitary adenoma, usually a corticotropin- and a prolactin-producing adenoma. The association of a craniopharyngioma and a pituitary adenoma is rare. Herein, we report the first case of an association between craniopharyngioma and silent pituitary adenoma subtype 3. It involved a 12-year-old boy who underwent a frontal craniotomy with surgical removal of a calcified sellar tumor. Histology revealed an adamantinomatous craniopharyngioma; however, by electron microscopy, there was conclusive evidence of adenoma cells showing the ultrastructural features of silent pituitary adenoma subtype 3. Endocrine and neuroimaging as well as detailed immunohistochemical and ultrastructural studies were undertaken. The literature is also reviewed.
authors.affiliation: Department of Laboratory Medicine, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada M5B 1W. olga_m99@hotmail.com
authors.forename: Olga
authors.initials: O
authors.lastname: Moshkin
authors.forename: Bernd W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: Luis V
authors.initials: LV
authors.lastname: Syro
authors.forename: Alejandro
authors.initials: A
authors.lastname: Velasquez
authors.forename: Eva
authors.initials: E
authors.lastname: Horvath
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D000236:Adenoma / Q000378:metabolism / Q000648:ultrastructure*; D002648:Child; D003397:Craniopharyngioma / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D046529:Microscopy, Electron, Transmission; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure*