title: ERK2 dependent signaling contributes to wound healing after a partial-thickness burn.
abstract: Burn healing is a complex physiological process involving multiple cell activities, such as cell proliferation, migration and differentiation. Although extracellular signal-regulated kinases (ERK) have a pivotal role in regulating a variety of cellular responses, little is known about the individual functions of ERK isoform for healing in vivo. This study investigated the role of ERK2 in burn healing. To assess this, Erk2(+/-) mice generated by gene targeting were used. The resultant mice exhibited significant delay in re-epithelization of partial-thickness burns in the skin in comparison to wild-type. An in vitro proliferation assay revealed that keratinocytes from Erk2(+/-) mice grew significantly slower than those prepared from wild-type. These results highlight the importance of ERK2 in the process of burn healing.
authors.affiliation: Department of Biochemistry, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan. ys@ndmc.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Satoh
authors.forename: Daizoh
authors.initials: D
authors.lastname: Saitoh
authors.forename: Atsuya
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ojima
authors.forename: Keita
authors.initials: K
authors.lastname: Kouzu
authors.forename: Saki
authors.initials: S
authors.lastname: Kawakami
authors.forename: Masataka
authors.initials: M
authors.lastname: Ito
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ishihara
authors.forename: Shunichi
authors.initials: S
authors.lastname: Sato
authors.forename: Kunio
authors.initials: K
authors.lastname: Takishima
mesh_terms: D000818:Animals; D002056:Burns / Q000201:enzymology* / Q000473:pathology; D049109:Cell Proliferation; D004195:Disease Models, Animal; D015603:Keratinocytes / Q000201:enzymology / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction; D012867:Skin / Q000201:enzymology* / Q000473:pathology; D014945:Wound Healing
chemical_list: D019950:Mitogen-Activated Protein Kinase 1