title: Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids.
abstract: BACKGROUND
  Keloids are a common problem with significant recurrence rates despite intralesional steroid treatment and multimodal therapy.
  
  
  OBJECTIVE
  The purpose of this study was to evaluate the efficacy of using a 5-fluorouracil (5-FU)/steroid mixture to treat keloids over the past 7 years, comparing the results with use of steroid treatment alone.
  
  
  METHODS
  Patient charts from 1999 to 2006 were reviewed. Patients were stratified into 3 groups: (1) 5-FU/steroid without excision; (2) 5-FU/steroid with excision; and (3) steroid treatment with excision. The percentage of lesion size reduction and symptoms were evaluated.
  
  
  RESULTS
  A total of 102 keloids were identified in a retrospective review. Patients who underwent the 5-FU/steroid combination with excision had a 92% average reduction in lesion size compared with 73% in the group of patients who did not receive 5-FU. Patients who received 5-FU/steroid without excision had an average lesion size reduction of 81%. Differences in complication rates were not statistically significant.
  
  
  CONCLUSIONS
  Combination 5-FU/triamcinolone is superior to intralesional steroid therapy in the treatment of keloids.
authors.affiliation: sDepartment of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. pd2@gunet.georgetown.edu
authors.forename: Steven P
authors.initials: SP
authors.lastname: Davison
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Dayan
authors.forename: Mark W
authors.initials: MW
authors.lastname: Clemens
authors.forename: Smitha
authors.initials: S
authors.lastname: Sonni
authors.forename: Antai
authors.initials: A
authors.lastname: Wang
authors.forename: Amy
authors.initials: A
authors.lastname: Crane
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D015552:Injections, Intralesional / Q000379:methods; D007627:Keloid / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage*
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D014221:Triamcinolone; D005472:Fluorouracil