title: Comparative analysis of five immunity-related genes reveals different levels of adaptive evolution in the virilis and melanogaster groups of Drosophila.
abstract: Five immunity-related genes previously reported to be evolving under positive selection in Drosophila melanogaster and D. simulans have been analysed across the Drosophila genus using two types of approaches, random-site and branch-site likelihood models as well as the proportion of synonymous and non-synonymous variation within and between species. Different selective pressures have been detected in the sample of genes, one showing evidence for adaptive evolution across the phylogeny of Drosophila and two showing lineage-specific positive selection. Furthermore, amino-acid sites identified as being under positive selection in the melanogaster and the virilis groups are different, suggesting that the evolution of the proteins in these two divergent groups may have been shaped by different pathogens.
authors.affiliation: Laboratório de Evolução Molecular, IBMC-Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal. rmhojas@ibmc.up.pt
authors.forename: R
authors.initials: R
authors.lastname: Morales-Hojas
authors.forename: C P
authors.initials: CP
authors.lastname: Vieira
authors.forename: M
authors.initials: M
authors.lastname: Reis
authors.forename: J
authors.initials: J
authors.lastname: Vieira
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D004330:Drosophila / Q000145:classification / Q000235:genetics* / Q000276:immunology / Q000502:physiology; D029721:Drosophila Proteins / Q000235:genetics* / Q000276:immunology; D019143:Evolution, Molecular; D005260:Female; D008297:Male; D010802:Phylogeny; D012641:Selection, Genetic
chemical_list: D029721:Drosophila Proteins