Type I natural killer T cells suppress tumors caused by p53 loss in mice.
CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53(+/-) mice lacking either type I NKT cells (TCR Jalpha18(-/-)) or all CD1d-restricted T cells (CD1d(-/-)). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development.
Swann
Jeremy B
JB
Peter MacCallum Cancer Centre, East Melbourne, Australia.
Uldrich
Adam P
AP
van Dommelen
Serani
S
Sharkey
Janelle
J
Murray
William K
WK
Godfrey
Dale I
DI
Smyth
Mark J
MJ
D000375:Aging / Q000276:immunology; D000818:Animals; D055610:Antigens, CD1d / Q000235:genetics; D003433:Crosses, Genetic; D005260:Female; D017353:Gene Deletion; D019673:Genes, T-Cell Receptor alpha; D016158:Genes, p53; D007157:Immunologic Surveillance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D055611:Natural Killer T-Cells / Q000145:classification / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000276:immunology*; D047368:Tumor Burden
D055610:Antigens, CD1d; C526879:Cd1d1 protein, mouse