title: [Rectal perforation in a patient treated with combination chemotherapy for lung cancer].
abstract: A 74-year old man was treated with first-cycle chemotherapy of paclitaxel (70 mg/m2=110 mg day 1, 8, 15) and carboplatin (AUC5=500 mg day 1) for lung cancer (c-T3N2M0, stage III A). On day 6 abdominal pain appeared, while on day 7 abdominal CT showed a perforation of the digestive tract. Thirty-three hours after the onset he underwent Hartmann operation during which we recognized a perforation 1.7 cm in size in the rectum. Although the cause of the perforation was unknown from the pathological findings, anticancer agents were suspected to be involved. Perforation should be taken into consideration in connection with acute abdominal disease after chemotherapy.
authors.affiliation: Dept. of Surgery, Yokohama Minami-Kyousai Hospital.
authors.forename: Joji
authors.initials: J
authors.lastname: Samejima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Adachi
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Saeki
authors.forename: Naoto
authors.initials: N
authors.lastname: Kato
authors.forename: Jun
authors.initials: J
authors.lastname: Fujisawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsukawa
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Rino
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D012002:Rectal Diseases / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery