[Effects of beta-lactam antibiotics on development of tolerance and dependence to morphine].
In order to identify ceftriaxone and its analogs whether has the function of anti-tolerance of morphine and study the dose-effect relation of ceftriaxone in mice, hot plate method to measure pain threshold of mouse and naloxone withdrawal models were carried out and compared with normal saline group. Ceftriaxone and cefotaxime had the effect of anti-tolerance and anti-dependence of morphine notably. And ceftriaxone has the effect of anti-tolerance of morphine in a dose dependent manner.
Wang
Meng
M
Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
Dong
Hua-Jin
HJ
Gong
Ze-Hui
ZH
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002439:Cefotaxime / Q000494:pharmacology; D002443:Ceftriaxone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence / Q000517:prevention & control*; D017288:Pain Threshold / Q000187:drug effects; D011897:Random Allocation; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone; D009020:Morphine; D002439:Cefotaxime