title: Acute postoperative pain predicts chronic pain and long-term analgesic requirements after breast surgery for cancer.
abstract: Postoperative pain and analgesic requirements may be associated with chronic pain. The aim of the study was to investigate this association. We studied 98 patients who had cancer breast surgery and served as controls in four previous studies, receiving placebo. We compared the pain and analgesic requirements 0-9 h and 1-6 days postoperatively: a) between patients with chronic pain 3 months postoperatively versus patients without and b) between those patients who consumed analgesics at home versus those who did not. Patients with chronic pain had experienced higher intensity pain at rest the first 9 postoperative hours (VAS-rest p = 0.033). Patients requiring analgesics at home had consumed postoperatively more opioids (p = 0.005) and more paracetamol (p = 0.037). These patients had experienced pain of higher intensity the first 9 postoperative hours (VAS-rest p = 0.022, VAS-movement p = 0.009) as well as during the six postoperative days (VAS-rest p = 0.013, VAS-movement p = 0.001). Higher intensities of acute postoperative pain are associated with chronic pain development. Higher analgesic needs and higher acute postoperatively pain intensity are associated with long-term analgesic consumption.
authors.affiliation: Department of Anaesthesia, Aretaieio Hospital, Medical School, University of Athens, Athens, Greece. fassoula@aretaieio.uoa.gr
authors.forename: A
authors.initials: A
authors.lastname: Fassoulaki
authors.forename: A
authors.initials: A
authors.lastname: Melemeni
authors.forename: C
authors.initials: C
authors.lastname: Staikou
authors.forename: A
authors.initials: A
authors.lastname: Triga
authors.forename: C
authors.initials: C
authors.lastname: Sarantopoulos
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D000698:Analgesia; D000700:Analgesics / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000601:surgery*; D016022:Case-Control Studies; D011431:Dextropropoxyphene / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000700:Analgesics; D000082:Acetaminophen; D009020:Morphine; D011431:Dextropropoxyphene