title: The efficacy of ranitidine bismuth citrate, amoxicillin and doxycycline or tetracycline regimens as a first line treatment for Helicobacter pylori eradication.
abstract: BACKGROUND
  The eradication rates of Helicobacter pylori (H. pylori) clearly decreased with standard PPI-based triple therapies.
  
  
  OBJECTIVE
  To assess the efficacy of two different triple therapies consisting of ranitidine bismuth citrate-amoxicillin-doxycycline and ranitidine bismuth citrate-amoxicillin-tetracycline combinations as a first line treatment option.
  
  
  METHODS
  One hundred and fifteen consecutive dyspeptic patients in whom H. pylori infection was diagnosed for the first time were enrolled in this study. The patients were randomized into two groups. Group 1 (n=57) was assigned to receive a 14-day triple therapy consisting of ranitidine bismuth citrate 400 mg (b.i.d.), amoxicillin 1 g (b.i.d) and doxycycline 100 mg (b.i.d.). Group 2 (n=58) was assigned to receive a 14-day triple therapy consisting of ranitidine bismuth citrate 400 mg (b.i.d.), amoxicillin 1 g (b.i.d.) and tetracycline 500 mg (q.i.d.).
  
  
  RESULTS
  The eradication was achieved in 45.7% (21/46) and 40.8% (20/49) of the patients in group 1 and group 2, according to per protocol analysis. The intention-to-treat eradication rates were 36.8% (21/57) and 34.5% (20/58) in group 1 and group 2, respectively.
  
  
  CONCLUSIONS
  Two-week therapy with neither ranitidine bismuth citrate-amoxicillin-doxycycline nor ranitidine bismuth citrate-amoxicillin-tetracycline is adequately effective for H. pylori eradication as a first line therapy.
authors.affiliation: Ege University Medical School, Department of Gastroenterology, Bornova, Izmir, Turkey. akyildizmr@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Akyildiz
authors.forename: Sinan
authors.initials: S
authors.lastname: Akay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Musoglu
authors.forename: Muge
authors.initials: M
authors.lastname: Tuncyurek
authors.forename: Ahmet
authors.initials: A
authors.lastname: Aydin
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D001729:Bismuth / Q000008:administration & dosage*; D004318:Doxycycline / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005756:Gastritis / Q000188:drug therapy / Q000382:microbiology; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013754:Tetracyclines / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D013754:Tetracyclines; C073340:ranitidine bismuth citrate; D000658:Amoxicillin; D011899:Ranitidine; D004318:Doxycycline; D001729:Bismuth