Effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors in rat brain.
We studied the effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors. L,D-Dipeptide more potently than L,L-dipeptide inhibited postsynaptic NMDA receptors, potentiated GABA and AMPA receptors, and inhibited (45)Ca(2+) uptake in synaptosomes from of rat brain cortex. Our results indicate that muramyl dipeptides modulate function of glutamate and GABA receptors.
Grigoriev
V V
VV
Laboratory for Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy Sciences, Chernogolovka, Moscow region, Russia. grigor@ipac.ac.ru
Petrova
L N
LN
Gabreliyan
A V
AV
Ivanova
T A
TA
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000187:drug effects* / Q000502:physiology; D018079:Receptors, GABA / Q000187:drug effects* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000502:physiology; D013237:Stereoisomerism; D009435:Synaptic Transmission / Q000187:drug effects
D018091:Receptors, AMPA; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D002118:Calcium