Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats.
OBJECTIVE
To investigate the protective effects of electroacupuncture (EA) pretreatment on acetylsalicylic acid (ASA)-induced ulceration in rats.


METHODS
We randomly divided 72 rats into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24 h before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured.


RESULTS
The lesion scores of the EA group were significantly lower than those of the ASA group. Gastric acidity of the ASA and EA groups was reduced compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and ASA groups, and NO levels were also significantly increased in the EA group as compared to the ASA group.


CONCLUSIONS
These results suggest that EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components.
Hwang
Hye-Suk
HS
Department of Medical Research, Korea Institute of Oriental Medicine, 483 Exporo, Yuseong-Gu, Daejeon, South Korea.
Han
Kyung-Ju
KJ
Ryu
Yeon-Hee
YH
Yang
Eun-Jin
EJ
Kim
Yoo-Sung
YS
Jeong
Sang-Yong
SY
Lee
Young-Seop
YS
Lee
Myeong-Soo
MS
Koo
Sung-Tae
ST
Choi
Sun-Mi
SM
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D051545:Cyclooxygenase 1 / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics; D004195:Disease Models, Animal; D015671:Electroacupuncture / Q000379:methods*; D005744:Gastric Acid / Q000378:metabolism; D005756:Gastritis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction
D012333:RNA, Messenger; D009569:Nitric Oxide; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D001241:Aspirin