Erythronolides H and I, new erythromycin congeners from a new halophilic actinomycete Actinopolyspora sp. YIM90600.
Erythronolides H and I, novel congeners of the clinically important antibacterial drug erythromycin A, have been isolated from the new halophilic actinomycete Actinopolyspora sp. YIM90600. In addition to producing the new erythromycin congeners, A. sp. YIM90600 produces erythromycin C in a high titer. The presence of the C-14 hydroxyl moiety and the C-6/C-18-epoxide in erythronolide H and the spiroketal moiety of erythronolide I sheds new insights into structural diversity of erythromycin analog libraries potentially accessible by combinatorial biosynthesis.
Huang
Sheng-Xiong
SX
Division of Pharmaceutical Sciences, Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
Zhao
Li-Xing
LX
Tang
Shu-Kun
SK
Jiang
Cheng-Lin
CL
Duan
Yanwen
Y
Shen
Ben
B
D000192:Actinomycetales / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; C539663:erythronolide H; C539664:erythronolide I; D004917:Erythromycin