title: Icosahedral DNA nanocapsules by modular assembly.
abstract: It's a trap! DNA polyhedra formed through molecular self-assembly may function as nanocapsules for the targeted delivery of encapsulated entities. This functional aspect was demonstrated for the most complex DNA-based platonic solid: During the stepwise amalgamation of discrete polyhedra to form icosahedra, gold nanoparticles (GNPs) were encapsulated from solution (see illustration and TEM image of icosahedral cages containing GNPs).
authors.affiliation: National Centre for Biological Sciences, TIFR, GKVK, Bellary Road, Bangalore, 560 065, India.
authors.forename: Dhiraj
authors.initials: D
authors.lastname: Bhatia
authors.forename: Shabana
authors.initials: S
authors.lastname: Mehtab
authors.forename: Ramya
authors.initials: R
authors.lastname: Krishnan
authors.forename: Shantinath S
authors.initials: SS
authors.lastname: Indi
authors.forename: Atanu
authors.initials: A
authors.lastname: Basu
authors.forename: Yamuna
authors.initials: Y
authors.lastname: Krishnan
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D009690:Nucleic Acid Conformation
chemical_list: D053769:Nanocapsules; D006046:Gold; D004247:DNA