Antibodies to tetanus, diphtheria and pertussis among healthy adults vaccinated according to the French vaccination recommendations.
In this sero-epidemiological study, we investigated humoral immunity to three vaccine-preventable diseases--tetanus, diphtheria and pertussis--among 331 adults (aged 18-60 years) attending vaccination centres for travellers and who had been vaccinated according to national recommendations in France. Serological results showed that the percentage of subjects with antibodies to diphtheria and tetanus decreases with age. Results also confirmed surveillance data on vaccination in France, with 7.6% of the study population (13.4% of those aged 18-29 years) having recently acquired a pertussis infection. These results confirm the importance of following French recommendations for regular boosters for tetanus and diphtheria among adults. They also indicate the need for better implementation of the current recommendations for pertussis-vaccine boosters in adults.
Launay
Odile
O
Faculté de médecine, Université Paris Descartes, Paris, France.
Toneatti
Christine
C
Bernède
Claire
C
Njamkepo
Elisabeth
E
Petitprez
Karine
K
Leblond
Annie
A
Larnaudie
Sylvie
S
Goujon
Catherine
C
Ungeheuer
Marie-Noelle
MN
Ajana
Faïza
F
Raccurt
Christian
C
Beytout
Jean
J
Chidiac
Christian
C
Bouhour
Damien
D
Guillemot
Didier
D
Guiso
Nicole
N
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood*; D004165:Diphtheria / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D005260:Female; D005602:France; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013742:Tetanus / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology; D055815:Young Adult
D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine