Total synthesis of cribrostatin 6.
Fast and furious: Cribrostatin 6, an antimicrobial and antineoplastic agent, was the target of a total synthesis where the longest linear sequence was only four steps. The key step involves a tandem 4pi electrocyclic ring opening, radical cyclization, and homolytic aromatic substitution sequence to afford the tricyclic core of the natural product.
Knueppel
Daniel
D
Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station-A5300, Austin, TX 78712-1167, USA.
Martin
Stephen F
SF
D003500:Cyclization; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis / Q000737:chemistry; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
D006575:Heterocyclic Compounds, 3-Ring; D007546:Isoquinolines; C477578:cribrostatin 6