[Protocol with GnRH-antagonist and ovulation trigger with GnRH-agonist in risk patients--a reliable method of prophylactic of OHSS].
OHSS is a serious complication of COH and PCOS is a major risk factor for its development.


OBJECTIVE
The objective of this study is to evaluate the effect of the application of GnRH-agonist in patients with PCOS for triggering the ovulation and prophylactic of OHSS.


METHODS
In the present study we evaluated 29 patients with PCOS who had been stimulated for the purposes of ART with gonadotrophins and GnRH-antagonist and application of GnRH-agonist (Decapeptyl; Dipherilyn-0.2 mg) instead of HCG.


RESULTS
From the observed group one patient developed severe form of late OHSS. The average number of aspirated oocytes was 22.5 and the clinical pregnancy was 46.8%.


CONCLUSIONS
The application of protocole with GnRH-antagonist and triggering of the ovulation with GnRH-agonist is a good alternative when a high risk of development of OHSS exists and our results prove that.
Kovachev
E
E
D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000819:agonists / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000517:prevention & control*; D010062:Ovulation Induction; D011247:Pregnancy; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; C061018:ganirelix