Ligand-based neutral ruthenium(II) arene complex: selective anticancer action.
Two new ruthenium(II) arene complexes, 2a (C(24)H(34)B(10)FeRuS(2)) and 2b (C(15)H(26)B(10)O(2)RuS(2)), bearing a carborane unit and other different functional groups were synthesized, and their cytostatic effects on cancerous cells were evaluated. Our observations illustrate that a structural change from a ferrocene unit to a carboxyl group could lead to high selectivity toward cancer cells and facilitate the efficient inhibition of the proliferation of target cells, indicating that the tuning of the overall properties of the ruthenium(II) arene complex by appropriate ligand tagging is critical to creating a selective antineoplastic agent.
Wu
Chun-Hui
CH
State Key Laboratory of Bioelectronics (Chien-Shiung Wu Laboratory), Southeast University, Nanjing, Jiangsu 210096, China.
Wu
De-Hong
DH
Liu
Xuan
X
Guoyiqibayi
Gulnisa
G
Guo
Da-Dong
DD
Lv
Gang
G
Wang
Xue-Mei
XM
Yan
Hong
H
Jiang
Hui
H
Lu
Zu-Hong
ZH
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008024:Ligands; D008113:Liver Neoplasms / Q000188:drug therapy*; D017975:Ruthenium Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D008024:Ligands; D017975:Ruthenium Compounds