Direct C-H borylation and C-H arylation of pyrrolo[2,3-d]pyrimidines: synthesis of 6,8-disubstituted 7-deazapurines.
Novel direct C-H borylations of 7-deazapurines to position 8 by B2pin2 under Ir catalysis were followed by Suzuki cross-couplings with aryl halides and other functional group transformations to give diverse 8-substituted 7-deazaadenines.
Klecka
Martin
M
Institute of Organic Chemistry and Biochemistry, v.v.i., Academy of Sciences of the Czech Republic, Gilead & IOCB Research Center, Flemingovo nam. 2, CZ-16610, Prague 6, Czech Republic.
Pohl
Radek
R
Klepetárová
Blanka
B
Hocek
Michal
M
D001896:Boron Compounds / Q000737:chemistry; D002384:Catalysis; D011687:Purines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry; D014372:Tubercidin
D001896:Boron Compounds; D011687:Purines; D011743:Pyrimidines; D011758:Pyrroles; D014372:Tubercidin