[Inhibition of (-)epigallocatechin gallate on dimethylarsinic acid promoting lung tumorigenesis through the induction of oxidative stress in mice].
OBJECTIVE
To investigate inhibition of ((-)epigallocatechin gallate, EGCG) on lung-tumor promotion and oxidative stress caused by administration of dimethylarsinic acid (DMA(V)) in mice.


METHODS
The experimental animal model, which is induced by lung tumor initiator (4NQO) and promoter (DMA(V)) in mice, was used to examine the effect of EGCG on DMA(V) promoting lung tumorigenesis. The 8-oxo-2'-deoxyguanosine (8-oxodG) analysis of lungs were used of HPLC.


RESULTS
The incidence of lung tumors induced by lung tumor initiator (4NQO) and promoter (DMA (V)) were, as well as 8-oxodG, suppressed by cotreatment with (-)epigallocatechin gallate (EGCG).


CONCLUSIONS
EGCG can inhibit the tumor promotion, which is associated with its inhibition of oxidative stress induced by DMA.
An
Yan
Y
Department of Toxicology, School of Radiation Medicine & Public Health Medical College of Soochow University, Suzhou 215123, China. dranyan@126.com
Li
Zhen
Z
Wang
Sanxiang
S
Wang
Zhenghui
Z
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002101:Cacodylic Acid / Q000633:toxicity*; D002392:Catechin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008175:Lung Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*
D000970:Antineoplastic Agents; D002392:Catechin; D002101:Cacodylic Acid; C045651:epigallocatechin gallate