title: [Report of a case effectively treated by appropriate therapy for severe anticipatory nausea and vomiting due to FOLFOX or FOLFIRI].
abstract: To date, the standard treatments for severe anticipatory nausea and vomiting is not well established. 5-HT3 antagonist is one of the effective drugs to reduce chemotherapy-induced nausea and vomiting, but had no effect on these symptoms for this patient. The patient could be successfully administered standard chemotherapy(FOLFOX or FOLFIRI, q2w)without adverse reactions by appropriate treatments in the form of increased doses of dexamethasone and normal dose administration of prochlorperazine. This report suggests a possibility that FOLFOX or FOLFIRI may be successfully treated by appropriate treatments for severe chemotherapy-induced vomiting colon cancer patients, and that this observation may lead to the improved prognosis of these patients.
authors.affiliation: Dept. of Pharmacy, Houju Memorial Hospital.
authors.forename: Mitsue
authors.initials: M
authors.lastname: Mori
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Kiba
authors.forename: Mika
authors.initials: M
authors.lastname: Oikawa
authors.forename: Kengou
authors.initials: K
authors.lastname: Hokkoku
authors.forename: Yuri
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakagawa
authors.forename: Kimiko
authors.initials: K
authors.lastname: Shintaku
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yoshimitsu
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakuma
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueda
authors.forename: Masuo
authors.initials: M
authors.lastname: Nakai
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002166:Camptothecin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil; D002166:Camptothecin