title: New prostaglandin derivative for glaucoma treatment.
abstract: A hydrogen sulphide-releasing derivative of latanoprost acid (ACS 67) was synthesized and tested in vivo to evaluate its activity on reduction of intraocular pressure and tolerability. Glutathione (GSH) and cGMP content were also measured in the aqueous humour. The increased reduction of intraocular pressure, with a marked increase of GSH and cGMP and the related potential neuroprotective properties, make this compound interesting for the treatment of glaucoma. This is the first time that an application of a hydrogen sulphide-releasing molecule is reported for the treatment of ocular diseases.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica 'Pietro Pratesi', University of Milan, Via Mangiagalli 25, 20133 Milan, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Perrino
authors.forename: Caterina
authors.initials: C
authors.lastname: Uliva
authors.forename: Cecilia
authors.initials: C
authors.lastname: Lanzi
authors.forename: Piero Del
authors.initials: PD
authors.lastname: Soldato
authors.forename: Emanuela
authors.initials: E
authors.lastname: Masini
authors.forename: Anna
authors.initials: A
authors.lastname: Sparatore
mesh_terms: D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D015195:Drug Design; D005128:Eye Diseases / Q000188:drug therapy*; D005901:Glaucoma / Q000628:therapy*; D005978:Glutathione / Q000737:chemistry; D006862:Hydrogen Sulfide / Q000737:chemistry; D007429:Intraocular Pressure; D000077338:Latanoprost; D008956:Models, Chemical; D018696:Neuroprotective Agents / Q000494:pharmacology; D011453:Prostaglandins / Q000627:therapeutic use*; D011461:Prostaglandins F, Synthetic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
chemical_list: D018696:Neuroprotective Agents; D011453:Prostaglandins; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D005978:Glutathione; D006862:Hydrogen Sulfide