title: Mitotic kinase dynamics of the active form of AMPK (phospho-AMPKalphaThr172) in human cancer cells.
abstract: When interrogating the activation status of AMP-activated protein kinase-measured as AMPKalpha(Thr172) phosphorylation-in tissue sections of human carcinomas and in cultured human cancer cells, the spatiotemporal dynamics of AMPK activity during the G(1)/S-to-M-phase transition strikingly resembles that of well-characterized "chromosomal passenger" proteins such as Aurora B, INCENP or Histone H3. The mitotic kinase behavior of the active form of AMPK may represent a candidate molecular link through which energy status directly influences tumorigenesis. A definitive elucidation of phospho-AMPKalpha(Thr172) in coordinating the chromosomal and cytoskeletal events of mitosis might radically amend our current perception of other AMPK-related diseases such as obesity, cardiac hypertrophy or accelerated aging syndromes.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Vazquez-Martin
authors.forename: Eugeni
authors.initials: E
authors.lastname: López-Bonet
authors.forename: Cristina
authors.initials: C
authors.lastname: Oliveras-Ferraros
authors.forename: Maria Carmen
authors.initials: MC
authors.lastname: Pérez-Martínez
authors.forename: Luis
authors.initials: L
authors.lastname: Bernadó
authors.forename: Javier A
authors.initials: JA
authors.lastname: Menendez
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D064107:Aurora Kinase B; D064127:Aurora Kinases; D045744:Cell Line, Tumor; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D016193:G1 Phase; D006657:Histones / Q000378:metabolism; D006801:Humans; D008938:Mitosis; D009369:Neoplasms / Q000201:enzymology*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D016196:S Phase
chemical_list: D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; C083767:INCENP protein, human; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases