Development and evaluation of pulsatile drug delivery  system using novel polymer.
The aim of the present investigation was to develop a pulsatile drug delivery system based on an insoluble capsule body filled with theophylline microspheres and sealed with a swellable novel polymer plug isolated from the endosperm of seeds of higher plant Delonix regia family-Fabaceae. Theophylline microspheres were prepared by solvent evaporation method using Eudragit S 100. The swellable plugs of varying thickness and hardness were prepared by direct compression, which were then placed in the capsule opening. The drug delivery system was designed to deliver the drug at such a time when it was needed most to offer convenience to the chronic patients of asthma. Formulated dosage forms were evaluated for an in vitro drug release study, which showed that the release might be consistent with a release time expected to deliver the drug to the colon depending on the thickness and hardness of the hydrogel plug. Thus, thickness and hardness of the novel polymeric plug plays an important role in controlling the drug release from the formulated drug delivery system.
Tekade
Avinash R
AR
Department of Pharmaceutics, R. C. Patel Institute of Pharmaceutical Education and Research, Shirpur (Dhule), India. avitekade@gmail.com
Gattani
Surendra G
SG
D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry; D002214:Capsules; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003106:Colon / Q000378:metabolism; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D007887:Fabaceae / Q000737:chemistry*; D006244:Hardness; D008863:Microspheres; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D012639:Seeds; D012997:Solvents / Q000737:chemistry; D013806:Theophylline / Q000008:administration & dosage / Q000737:chemistry*
D001993:Bronchodilator Agents; D002214:Capsules; D003692:Delayed-Action Preparations; D005079:Excipients; D011108:Polymers; D011109:Polymethacrylic Acids; D012997:Solvents; C038300:methylmethacrylate-methacrylic acid copolymer; D013806:Theophylline