title: Genomic profiling of breast cancer.
abstract: Genome study provides significant changes in the advancement of molecular diagnosis and treatment in Breast cancer. Several recent critical advances and high-throughput techniques identified the genomic trouble and dramatically accelerated the pace of research in preventing and curing this malignancy. Tumor-suppressor genes, proto-oncogenes, DNA-repair genes, carcinogen-metabolism genes are critically involved in progression of breast cancer. We reviewed imperative finding in breast genetics, ongoing work to segregate further susceptible genes, and preliminary studies on molecular profiling.
authors.affiliation: Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
authors.forename: Anjita
authors.initials: A
authors.lastname: Pandey
authors.forename: Alok Kumar
authors.initials: AK
authors.lastname: Singh
authors.forename: Sanjeev Kumar
authors.initials: SK
authors.lastname: Maurya
authors.forename: Rajani
authors.initials: R
authors.lastname: Rai
authors.forename: Mallika
authors.initials: M
authors.lastname: Tewari
authors.forename: Mohan
authors.initials: M
authors.lastname: Kumar
authors.forename: Hari S
authors.initials: HS
authors.lastname: Shukla
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D002273:Carcinogens / Q000378:metabolism; D002877:Chromosomes, Human; D019175:DNA Methylation; D004260:DNA Repair / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D015894:Genome, Human; D006801:Humans; D019656:Loss of Heterozygosity; D011519:Proto-Oncogenes
chemical_list: D002273:Carcinogens