Intravenous esomeprazole for prevention of recurrent peptic ulcer bleeding: a randomized trial.
BACKGROUND
Use of proton-pump inhibitors in the management of peptic ulcer bleeding is controversial because discrepant results have been reported in different ethnic groups.


OBJECTIVE
To determine whether intravenous esomeprazole prevents recurrent peptic ulcer bleeding better than placebo in a multiethnic patient sample.


METHODS
Randomized trial conducted between October 2005 and December 2007; patients, providers, and researchers were blinded to group assignment.


METHODS
91 hospital emergency departments in 16 countries.


METHODS
Patients 18 years or older with peptic ulcer bleeding from a single gastric or duodenal ulcer showing high-risk stigmata.


METHODS
Intravenous esomeprazole bolus, 80 mg, followed by 8-mg/h infusion, over 72 hours or matching placebo, each given after successful endoscopic hemostasis. Intervention was allocated by computer-generated randomization. After infusion, both groups received oral esomeprazole, 40 mg/d, for 27 days.


METHODS
The primary end point was rate of clinically significant recurrent bleeding within 72 hours. Recurrent bleeding within 7 and 30 days, death, surgery, endoscopic re-treatment, blood transfusions, hospitalization, and safety were also assessed.


RESULTS
Of 767 patients randomly assigned, 764 provided data for an intention-to-treat analysis (375 esomeprazole recipients and 389 placebo recipients). Fewer patients receiving intravenous esomeprazole (22 of 375) had recurrent bleeding within 72 hours than those receiving placebo (40 of 389) (5.9% vs. 10.3%; difference, 4.4 percentage points [95% CI, 0.6% to 8.3%]; P = 0.026). The difference in bleeding recurrence remained significant at 7 days and 30 days (P = 0.010). Esomeprazole also reduced endoscopic re-treatment (6.4% vs. 11.6%; difference, 5.2 percentage points [95% CI of difference, 1.1 percentage points to 9.2 percentage points]; P = 0.012), surgery (2.7% vs. 5.4%), and all-cause mortality rates (0.8% vs. 2.1%) more than placebo, although differences for the latter 2 comparisons were not significant. About 10% and 40% of patients in both groups reported serious and nonserious adverse events, respectively.


CONCLUSIONS
Endoscopic therapy was not completely standardized; some patients received epinephrine injection, thermal coagulation, or hemoclips alone, whereas others received combination therapy, but there were similar proportions with single therapy in each group.


CONCLUSIONS
High-dose intravenous esomeprazole given after successful endoscopic therapy to patients with high-risk peptic ulcer bleeding reduced recurrent bleeding at 72 hours and had sustained clinical benefits for up to 30 days.


BACKGROUND
AstraZeneca Research and Development.
Sung
Joseph J Y
JJ
Institute of Digestive Diseases, Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong, China. joesung@cuhk.edu.hk
Barkun
Alan
A
Kuipers
Ernst J
EJ
Mössner
Joachim
J
Jensen
Dennis M
DM
Stuart
Robert
R
Lau
James Y
JY
Ahlbom
Henrik
H
Kilhamn
Jan
J
Lind
Tore
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D064098:Esomeprazole / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D016558:Hemostasis, Endoscopic / Q000379:methods; D006801:Humans; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control* / Q000628:therapy; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects; D019233:Retreatment; D055502:Secondary Prevention
D054328:Proton Pump Inhibitors; D064098:Esomeprazole