[Non-developing pregnancy: histological and immunohistochemical markers of endocrine disorders in endometrial scrapes].
Histological and immunohistological (monoclonal antibodies against desmin, vimentin, glycodelin, IGFBP-1, estrogen receptors and progesterone receptors) studies were carried out to examine uterine scrapes from 47 healthy women - medical abortions from 6 to 10 weeks of conception and from 44 patients after non-developing pregnancy in the first trimester (recurrent miscarriage), which had been induced by verified endocrine disorders. Among them, three isolated pathogenetic types were identified: 1) uterine gland retardation as preserved islets of cylindrical glands with a narrow lumen or, on the contrary, areas with enlarged glands and atrophic epitheliocytes; immunohistochemically, they exhibited a drastic reduction in the expression of glycodelin, the major local immunosuppressor; 2) incomplete decidualization when it in the presence of progesterone deficiency was delayed at the state of predecidual and decidual cells retaining the smooth muscle cell marker - desmin; 3) verified progesterone receptor insufficiency. Each of the given clinical and morphological types of endocrine causes of non-developing pregnancy requires that an individual approach be applied to examining and treating these patients.
Milovanov
A P
AP
Boltovskaia
M N
MN
Fokina
T V
TV
Starosvetskaia
N A
NA
Nazimova
S V
SV
D000030:Abortion, Missed / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D003893:Desmin / Q000378:metabolism; D004700:Endocrine System Diseases / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D004717:Endometrium / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D015415:Biomarkers; D003893:Desmin; D018970:Insulin-Like Growth Factor Binding Protein 1; D014746:Vimentin