[Immunomorphological features of cutaneous basal-cell carcinoma].
An immunohistochemical study of p53, Ki-67, bcl-2, CK-8 and collagen IV was conducted in 47 basal-cell carcinomas (BCC) to ascertain their prognostic value. The increasing index of the proliferative markers (Ki-67 up to 55.71 and p53 up to 63.29%, respectively) was characteristic of infiltrative BCC (p = 0.017-0.027). There was a distinct correlation between p53 and Ki-67 levels, on the one hand, and the main clinico-morphological features of BCC (r=0.63-0.78), on the other. Elevated expression of proliferative markers proved to be a factor of unfavorable prognosis. High anti-apoptotic bcl-2 expression in superficial BCC (36.85%) was matched by its decrease in nodular carcinoma and was minimal in high grade infiltrative BCC (13.24%). CK-8 expression did not vary significantly within the 67.21-71.39% of tumor cells as far as different histotopographic patterns are concerned. Most prominent basement membrane ruptures, as evaluated by collagen IV expression, occurred in infiltrative BCC (p=0.008).
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001485:Basement Membrane / Q000737:chemistry / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000276:immunology; D002280:Basal Cell Carcinoma / Q000737:chemistry* / Q000473:pathology*; D024141:Collagen Type IV / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053533:Keratin-8 / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D014408:Biomarkers, Tumor; D024141:Collagen Type IV; D053533:Keratin-8; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53