title: Soft tissue reconstruction using vascularized tissue transplantation following resection of musculoskeletal sarcoma: evaluation of oncologic and functional outcomes in 55 cases.
abstract: Oncologic resection of musculoskeletal sarcoma sometimes requires reconstruction with vascularized soft tissue transplantation. To date, few reports have described treatment outcomes of such cases. In the present study, 55 cases were enrolled to examine oncologic/functional outcomes, complications, and the risks for poor results. Five-year local recurrence-free survival, metastasis-free survival, and total survival rates were 83.0%, 87.6%, and 79.8%, respectively. In univariate analysis, bone origin was a risk for local recurrence. Local recurrence, inadequate margin, and trunk location were risks for metastasis, and inadequate margin and trunk location were risks for total survival. In multivariate analysis, local recurrence represented an independent risk for metastasis. The mean functional rating (Enneking) was 85.6%. Infection, distant metastasis, local recurrence, and prolonged operation time were risks for poor function. Use of artificial materials revealed a risk for infection. The results suggested that adequate margin and prevention of infection were critical to ensure excellent outcome.
authors.affiliation: Department of Orthopaedic Surgery, Kyorin University, School of Medicine, Tokyo, Japan. t-morii@kyorin-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Morii
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mochizuki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Takushima
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Okazaki
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Satomi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000601:surgery*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D020127:Recovery of Function; D012509:Sarcoma / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000601:surgery*; D013524:Surgical Flaps / Q000098:blood supply*; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000209:etiology / Q000601:surgery*; D055815:Young Adult