title: Worry exposure versus applied relaxation in the treatment of generalized anxiety disorder.
abstract: BACKGROUND
  Worry exposure (WE) is a core element of cognitive-behavioral treatment for generalized anxiety disorder (GAD). Its efficacy as a stand-alone treatment method (without further cognitive-behavioral therapy interventions) has never been tested.We aimed to examine whether WE alone is as efficacious as the empirically supported stand-alone treatment for GAD, applied relaxation (AR).
  
  
  METHODS
  In a randomized controlled study, 73 outpatients meeting DSM-IV criteria for GAD as primary diagnosis were allocated to either WE or AR or a waiting list control group; in a 2nd randomization procedure the waiting list subjects were reallocated to WE or AR. The treatment was manualized (15 sessions with WE or AR), included 6-month and 1-year follow-ups, as well as last observation carried forward and completer analyses, and was controlled for allegiance effects.The Hamilton Anxiety Rating Scale and the State-Trait Anxiety Scale were used as primary outcome measures. Self-report scales of anxiety, worrying and depression including negative metacognition about worrying and thought suppression served as secondary outcome measures.
  
  
  RESULTS
  The dropout rate was moderate. The pre-/posttreatment effects were high for the Hamilton Anxiety Rating Scale (standardized mean difference >1) and for the State-Trait Anxiety Inventory (standardized mean difference >0.87). The proportion of patients reaching high end state functioning was 48% (WE) and 56% (AR). WE and AR did not differ with regard to dropout rate or treatment effects. The treatment effects were stable at 6 month and 1 year follow-up.
  
  
  CONCLUSIONS
  This is the first study to show that a stand-alone exposure in sensu technique--WE--is efficacious in the treatment of GAD. Both AR and WE seem to represent effective principles of change in GAD.
authors.affiliation: Clinical Psychology and Psychotherapy, Technische Universitat Dresden, Dresden, Germany. hoyer@psychologie.tu-dresden.de
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hoyer
authors.forename: Katja
authors.initials: K
authors.lastname: Beesdo
authors.forename: Andrew T
authors.initials: AT
authors.lastname: Gloster
authors.forename: Juliane
authors.initials: J
authors.lastname: Runge
authors.forename: Michael
authors.initials: M
authors.lastname: Höfler
authors.forename: Eni S
authors.initials: ES
authors.lastname: Becker
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D012064:Relaxation Therapy / Q000379:methods*; D011795:Surveys and Questionnaires; D013850:Thinking