title: Formation and dissolution of hen egg white lysozyme amyloid fibrils in protic ionic liquids.
abstract: The formation of amyloid fibrils from non-disease-related proteins demonstrates that any protein can adopt this "rogue" form; we show that it is possible to use protic ionic liquids to fibrilize hen egg white lysozyme, and then subsequently to dissolve the fibrils with up to 72% restoration of enzymatic activity.
authors.affiliation: Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. nolene.byrne@asu.edu
authors.forename: Nolene
authors.initials: N
authors.lastname: Byrne
authors.forename: C Austen
authors.initials: CA
authors.lastname: Angell
mesh_terms: D000682:Amyloid / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D000818:Animals; D002645:Chickens; D002942:Circular Dichroism; D052578:Ionic Liquids / Q000737:chemistry*; D009113:Muramidase / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure; D020673:Protein Renaturation
chemical_list: D000682:Amyloid; D052578:Ionic Liquids; C421864:hen egg lysozyme; D009113:Muramidase