title: The effect of periodontal therapy on serum TNF-alpha and HbA1c levels in type 2 diabetic patients.
abstract: BACKGROUND
  To determine the effect of non-surgical periodontal therapy on serum TNF-alpha and HbA1c levels in poorly and well-controlled type 2 diabetic patients.
  
  
  METHODS
  In total, 45 patients were enrolled in the study; 30 patients with type 2 diabetes mellitus with periodontitis (15 with poorly controlled diabetes, HbA1c >or= 7%, group 1A and 15 with well-controlled diabetes, HbA1c < 7%, group 1B) and 15 patients that were systemically healthy with periodontitis (group 2). The plaque index, gingival index, probing depth, clinical attachment loss, gingival bleeding index, HbA1c value, and circulating TNF-alpha concentration were measured at baseline and three months after the non-surgical periodontal therapy.
  
  
  RESULTS
  All periodontal parameters and serum TNF-alpha levels were significantly decreased three months after the non-surgical periodontal therapy compared to the baseline values in all groups. The HbA1c values were significantly decreased only in well-controlled diabetic patients. We found no significant differences in the periodontal parameters or TNF-alpha levels at baseline and after three months between the two groups.
  
  
  CONCLUSIONS
  Although non-surgical periodontal therapy eliminates local/systemic infection and inflammation via decreases in TNF-alpha, it is insufficient for significantly reducing HbA1c levels without strict glycaemic control in poorly controlled diabetic patients in a short time period.
authors.affiliation: Department of Periodontology, Faculty of Dentistry, Dicle University, Turkey. adag@dicle.edu.tr
authors.forename: A
authors.initials: A
authors.lastname: Dağ
authors.forename: E T
authors.initials: ET
authors.lastname: Firat
authors.forename: S
authors.initials: S
authors.lastname: Arikan
authors.forename: A K
authors.initials: AK
authors.lastname: Kadiroğlu
authors.forename: A
authors.initials: A
authors.lastname: Kaplan
mesh_terms: D055113:Chronic Periodontitis / Q000097:blood / Q000150:complications / Q000628:therapy*; D003774:Dental Plaque Index; D012534:Dental Scaling; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D006442:Glycated Hemoglobin; D014409:Tumor Necrosis Factor-alpha