title: Determination of the minimum alveolar concentration for halothane, isoflurane and sevoflurane in the gerbil.
abstract: The present work determined the minimum alveolar concentrations (MAC) of halothane, isoflurane and sevoflurane in adult female gerbils (n=24). Animals were placed in a chamber for anaesthetic induction before performing tracheal intubation. The tracheal tube was connected to a non-rebreathing circuit with minimal dead space. Body temperature, blood pressure, heart and respiratory rates and end-tidal volatile anaesthetic levels were measured continuously. MAC was determined using a standard noxious stimulus (tail-clamp). All experiments were performed at the same time of the day, body temperature was maintained constant and blood-gas analysis was performed to confirm that values were within normal limits. The mean+/-SD MAC values were 1.06+/-0.11% halothane (n=8), 1.55+/-0.08% isoflurane (n=8) and 2.90+/-0.12% sevoflurane (n=7). Cardiovascular parameters at 1xMAC did not differ significantly among anaesthetics but the respiratory rate was significantly higher in the halothane group than in the isoflurane and sevoflurane groups. The SpO2 values recorded throughout anaesthesia and the pH and partial oxygen pressure values determined at the end of the study did not differ among the studied anaesthetics at 1xMAC. These data suggest that the MAC for halogenated inhalant anaesthetics in gerbils is lower than the average MAC values obtained in rats and mice.
authors.affiliation: Department of Animal Medicine and Surgery, Veterinary Faculty, University Complutense of Madrid, Avda. Puerta de Hierro, 28040 Madrid, Spain. iagsegura@vet.ucm.es
authors.forename: I A Gómez
authors.initials: IA
authors.lastname: de Segura
authors.forename: J Benito
authors.initials: JB
authors.lastname: de la Víbora
authors.forename: A
authors.initials: A
authors.lastname: Criado
mesh_terms: D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D000818:Animals; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001831:Body Temperature / Q000187:drug effects / Q000502:physiology; D005260:Female; D005849:Gerbillinae; D006221:Halothane / Q000493:pharmacokinetics*; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D007442:Intubation, Intratracheal; D007530:Isoflurane / Q000493:pharmacokinetics*; D008738:Methyl Ethers / Q000493:pharmacokinetics*; D011650:Pulmonary Alveoli / Q000378:metabolism*; D012119:Respiration / Q000187:drug effects; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane; D006221:Halothane