title: Dental implants in a patient with Paget disease under bisphosphonate treatment: a case report.
abstract: Paget disease (PD) is an idiopathic disorder characterized by progressive enlargement and deformity of bones, resulting in structural weakness that may be unfavorable for the placement of osseointegrated dental implants. Currently, bisphosphonates are administered for the treatment of PD. However, the use of bisphosphonates has been associated with the onset of osteonecrosis of the jaws. This report deals with a case of a 64-year-old caucasian woman diagnosed with polyostotic PD 17 years earlier who had been treated with bisphosphonates for 7 years. The patient was referred for implant treatment, and after initial placement of 6 fixtures, the postoperative course was uneventful and no complications were registered during a follow-up period of 4 years. Within the limitations of this case, we report that dental implants can be successfully placed and loaded in patients suffering from PD without discontinuing the treatment with bisphosphonates, as long as the patient is not complaining from any additional unfavorable conditions. To the best of our knowledge, this is a unique case describing the successful placement of dental implants in a patient with PD treated with bisphosphonates. Nevertheless, more studies would be needed to optimize the clinical guidelines for the treatment of these patients.
authors.affiliation: Department of Health Sciences III, Faculty of Health Sciences, Rey Juan Carlos University, Madrid, Spain.
authors.forename: Jesús
authors.initials: J
authors.lastname: Torres
authors.forename: Faleh
authors.initials: F
authors.lastname: Tamimi
authors.forename: Ignacio
authors.initials: I
authors.lastname: Garcia
authors.forename: Alicia
authors.initials: A
authors.lastname: Herrero
authors.forename: Begoña
authors.initials: B
authors.lastname: Rivera
authors.forename: Jose Andrés
authors.initials: JA
authors.lastname: Sobrino
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Hernández
mesh_terms: D000284:Administration, Oral; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003758:Dental Implantation, Endosseous; D019094:Dental Prosthesis, Implant-Supported; D003830:Denture, Partial, Fixed; D012968:Etidronic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007576:Jaw, Edentulous, Partially / Q000150:complications / Q000534:rehabilitation; D008437:Maxilla; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications / Q000188:drug therapy*; D000068296:Risedronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D000068296:Risedronic Acid; D012968:Etidronic Acid