Synthesis of spiroheterocycles by palladium-catalyzed domino cycloisomerization/cross-coupling of alpha-allenols and Baylis-Hillman acetates.
First insights into the reaction between a Baylis-Hillman adduct and an allene moiety have been obtained from the novel domino heterocyclization/cross-coupling reaction of alpha-allenols and Baylis-Hillman acetates, which furnishes [(2,5-dihydrofuran-3-yl)methyl]acrylate derivatives in moderate to good yields.
Alcaide
Benito
B
Departamento de Química Orgánica I, Facultad de Química, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Almendros
Pedro
P
Martínez Del Campo
Teresa
T
Quirós
M Teresa
MT