Tissue analysis with high-resolution imaging mass spectrometry.
Molecular mass spectrometric images of tissue sections facilitate precise location of biomolecules, drugs, their metabolites and the biomolecular aberrations they target. Technological developments are rapidly expanding the capabilities of imaging mass spectrometers. Speed, resolution, sensitivity, and sample preparation protocols are no longer limiting factors in its application.
Altelaar
A F Maarten
AF
FOM Institute for Atomic and Molecular Physics FOM-AMOLF, Amsterdam, The Netherlands.
Heeren
Ron M A
RM
D053000:Analytic Sample Preparation Methods; D000818:Animals; D001921:Brain / Q000166:cytology*; D013058:Mass Spectrometry / Q000379:methods*; D025341:Principal Component Analysis; D051381:Rats; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization