title: A case of late-onset Tourette's disorder successfully treated with aripiprazole: view from blood levels of catecholamine metabolites and brain-derived neurotrophic factor (BDNF).
abstract: We reported a case with late-onset Tourette's disorder (TD) in whom motor tics and emotional instability improved with 18 mg/day of aripiprazole treatment. Plasma HVA levels, but not MHPG levels, were altered during the treatment. In contrast, serum BDNF levels remained consistently low during the treatment course. The present case suggests that aripiprazole might ameliorate tics and emotional instability via influencing dopaminergic neurons in late-onset TD.
authors.affiliation: Department of Psychiatry, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan. atsuko-i@med.uoeh-u.ac.jp
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ikenouchi-Sugita
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Hayashi
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ueda
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene-Nakano
authors.forename: Hikaru
authors.initials: H
authors.lastname: Hori
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura
mesh_terms: D000367:Age Factors; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole; D001921:Brain / Q000000981:diagnostic imaging; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood / Q000378:metabolism*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D005879:Tourette Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D002395:Catecholamines; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole