Dual loss of Rb1 and Trp53 in melanocytes perturbs melanocyte homeostasis and genetic stability in vitro but does not cause melanoma or pigmentation defects in vivo.
Tonks
Ian D
ID
Mould
Arne
A
Nurcombe
Victor
V
Cool
Simon M
SM
Walker
Graeme J
GJ
Hacker
Elke
E
Keith
Patricia
P
Schroder
Wayne A
WA
Cotterill
Andrew
A
Hayward
Nicholas K
NK
Kay
Graham F
GF
D000818:Animals; D006706:Homeostasis; D008544:Melanocytes / Q000166:cytology / Q000378:metabolism*; D008545:Melanoma / Q000378:metabolism*; D051379:Mice; D008822:Mice, Transgenic; D010858:Pigmentation; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53