title: Engineering parathyroid cells to treat secondary hyperparathyroidism.
abstract: Kanai et al. used antisense technology to reduce excessive PTH production. The authors have overcome technical difficulties to demonstrate that, by strategies of RNA interference, a steady reduction of PTH secretion can be induced in cultured parathyroid-cell spheroids and in athymic nude mice with hyperplastic parathyroid cells transplanted from patients with secondary hyperparathyroidism.
authors.affiliation: Unidad de Investigación, Servicio de Nefrología, Hospital Universitario Reina Sofía, Córdoba, Spain. juanm.rodriguez.sspa@juntadeandalucia.es
authors.forename: Mariano
authors.initials: M
authors.lastname: Rodríguez
authors.forename: Julio M
authors.initials: JM
authors.lastname: Martinez-Moreno
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Almadén
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques; D017690:Cell Transplantation; D015536:Down-Regulation / Q000235:genetics; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000628:therapy*; D051379:Mice; D010280:Parathyroid Glands / Q000166:cytology*; D010281:Parathyroid Hormone / Q000096:biosynthesis / Q000235:genetics; D034622:RNA Interference
chemical_list: D010281:Parathyroid Hormone