title: [Precocious puberty due to hypothalamic hamartoma].
abstract: BACKGROUND
  Central precocious puberty is usually idiopathic. Appearance of the precocious puberty symptoms in early childhood or pre-school period indicate that also it could be caused by organic disorder of the central nervous system. The aim of this work is to present the case of the 4-year-old girl, diagnosed with precocious puberty.
  The first clinical symptoms of precocious puberty such as increased growth rate and breast enlargement were observed when the girl was 4 years old. The height (above the 97 centile) and weight (90-97 centile) were measured during the physical examination. The advancement of sexual features was determined as follows: thelarche III degrees , pubarche II degrees , axillarche II degrees . The LHRH test used in this differential diagnosis revealed the pubertal level of gonadotropins, when plasma levels of dehydroepiandrosterone, prolactin, thyroid-stimulating hormone and alpha-fetoprotein levels were correct. The advanced bone age was 8 years and 10 months, while the height age was 7 years. The final diagnosis was based on MRI scan. The patient is currently treated with an analog of gonadoliberine (Diphereline). In conclusion, we aspired to notice that the pharmacological treatment of hypothalamic hamartoma may be safe and effective. Suppression of puberty to the normal time of pubescence gives a child the chance to reduce health discomforts as well as further emotional and social problems.
authors.affiliation: Koło Naukowe przy ll Klinice Chorób Dzieci UM w Białymstoku.
authors.forename: Magdalena
authors.initials: M
authors.lastname: Luba
authors.forename: Artur
authors.initials: A
authors.lastname: Bossowski
authors.forename: Justyna
authors.initials: J
authors.lastname: Kulikowska
authors.forename: Mirosława
authors.initials: M
authors.lastname: Urban
authors.forename: Maria
authors.initials: M
authors.lastname: Szarras-Czapnik
authors.forename: Robert
authors.initials: R
authors.lastname: Rutkowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Parol
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gasiorek
authors.forename: Beata
authors.initials: B
authors.lastname: Sawicka
authors.forename: Marcin
authors.initials: M
authors.lastname: Skrzydło
mesh_terms: D002675:Child, Preschool; D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000175:diagnosis*; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000175:diagnosis*; D011629:Puberty, Precocious / Q000209:etiology*