Designing efficient zero calibration point for phase-sensitive surface plasmon resonance biosensing.
This work is related to the development of phase-sensitive methodologies in Surface Plasmon Resonance (SPR) biosensing. We take advantage of a specific angular dependence of phase of light, reflected under SPR geometry, on parameters of the SPR-supporting metal, and propose a polarimetry-based methodology to easily determine the optimal calibration zero point, corresponding to the maximal phase sensitivity. The proposed methodology can significantly facilitate the calibration of the system in field and multi-channel sensing, broaden the dynamic range, as well as contribute to the development of feedback loops.
Patskovsky
S
S
Engineering Physics Department, Ecole Polytechnique de Montréal, C. P. 6079, succ. Centre-Ville, Montréal (Québec), Canada, H3C 3A7.
Vallieres
M
M
Maisonneuve
M
M
Song
In-Hyouk
IH
Meunier
M
M
Kabashin
A V
AV
D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods* / Q000592:standards; D002138:Calibration; D017076:Computer-Aided Design; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008670:Metals / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods* / Q000592:standards
D008670:Metals