title: High-density peptide arrays.
abstract: Arrays promise to advance biology by allowing parallel screening for many different binding partners. Meanwhile, lithographic methods enable combinatorial synthesis of > 50,000 oligonucleotides per cm(2), an advance that has revolutionized the whole field of genomics. A similar development is expected for the field of proteomics, provided that affordable, very high-density peptide arrays are available. However, peptide arrays lag behind oligonucleotide arrays. This review discusses recent developments in the field with an emphasis on methods that lead to very high-density peptide arrays.
authors.affiliation: German Cancer Research Center, Im Neuenheimer Feld 580, Heidelberg, Germany. f.breitling@dkfz.de
authors.forename: Frank
authors.initials: F
authors.lastname: Breitling
authors.forename: Alexander
authors.initials: A
authors.lastname: Nesterov
authors.forename: Volker
authors.initials: V
authors.lastname: Stadler
authors.forename: Thomas
authors.initials: T
authors.lastname: Felgenhauer
authors.forename: F Ralf
authors.initials: FR
authors.lastname: Bischoff
mesh_terms: D020650:Combinatorial Chemistry Techniques; D010455:Peptides / Q000138:chemical synthesis*; D040081:Protein Array Analysis; D011506:Proteins / Q000138:chemical synthesis
chemical_list: D010455:Peptides; D011506:Proteins