Vascular calcification in chronic kidney disease: a clinical review.
Vascular calcification, which is associated with arterial stiffness, is now known to be an important predictor of cardiovascular and all-cause mortality in patients with renal disease. This calcification starts developing in the early stages of chronic kidney disease (CKD) and is present in over 50% of patients at the time of dialysis commencement. Once calcification is present it continues to progress, though some medications have been shown to slow this progression. Vascular calcification and bone abnormalities are now both encompassed by the term of CKD-mineral bone disorder and are thought to be part of the same disease process in CKD. Vascular calcification and arterial stiffness have been extensively researched in the renal population and many factors are known to be associated with their presence and progression. This calcification is an important factor to be considered in the management of the renal patient but there are different methods available for its measurement. These details will be discussed further in this review along with evidence available for management of this important complication of renal disease.
Eddington
Helen
H
Vascular Research Group, Salford Royal Foundation NHS Trust, Stott Lane, Salford M6 8HD, UK.
Sinha
Smeeta
S
Kalra
Philip A
PA
D002114:Calcinosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D002318:Cardiovascular Diseases / Q000209:etiology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology; D018450:Disease Progression; D055317:Evidence-Based Practice; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D009398:Nephrology; D015995:Prevalence; D006435:Renal Dialysis; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D014652:Vascular Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy