Forensic applications of ambient ionization mass spectrometry.
This review highlights and critically assesses forensic applications in the developing field of ambient ionization mass spectrometry. Ambient ionization methods permit the ionization of samples outside the mass spectrometer in the ordinary atmosphere, with minimal sample preparation. Several ambient ionization methods have been created since 2004 and they utilize different mechanisms to create ions for mass-spectrometric analysis. Forensic applications of these techniques--to the analysis of toxic industrial compounds, chemical warfare agents, illicit drugs and formulations, explosives, foodstuff, inks, fingerprints, and skin--are reviewed. The minimal sample pretreatment needed is illustrated with examples of analysis from complex matrices (e.g., food) on various substrates (e.g., paper). The low limits of detection achieved by most of the ambient ionization methods for compounds of forensic interest readily offer qualitative confirmation of chemical identity; in some cases quantitative data are also available. The forensic applications of ambient ionization methods are a growing research field and there are still many types of applications which remain to be explored, particularly those involving on-site analysis. Aspects of ambient ionization currently undergoing rapid development include molecular imaging and increased detection specificity through simultaneous chemical reaction and ionization by addition of appropriate chemical reagents.
Ifa
Demian R
DR
Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907, USA.
Jackson
Ayanna U
AU
Paglia
Giuseppe
G
Cooks
R Graham
RG
D002619:Chemical Warfare Agents / Q000032:analysis; D053834:Explosive Agents / Q000032:analysis; D005504:Food Analysis / Q000295:instrumentation / Q000379:methods; D044707:Forensic Sciences / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D013287:Illicit Drugs / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis; D012867:Skin / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000295:instrumentation / Q000379:methods*
D002619:Chemical Warfare Agents; D053834:Explosive Agents; D013287:Illicit Drugs; D004364:Pharmaceutical Preparations