title: Patterns of early change and their relationship to outcome and follow-up among patients with major depressive disorders.
abstract: BACKGROUND
  While highlighting the efficacy of different treatments for major depressive disorders (MDD), findings of the National Institute of Mental Health (NIMH) Treatment of Depression Collaborative Research Program (TDCRP) often are interpreted as supporting the idea of treatment non-specificity for MDD. However, heterogeneity in treatment courses and outcomes might be undetected when focusing only on types of treatment in terms of sample means without taking into account early change in treatment.
  
  
  METHODS
  In this study, growth mixture models (GMM) were used in the completer sample of N=162 patients from the NIMH TDCRP to identify meaningful patterns of early change of depression severity that are shared by many individual patients.
  
  
  RESULTS
  Results revealed three typical patterns of early change over the first 8 weeks of treatment irrespective of the type of treatment protocol provided: (a) moderate to severe depression with moderate early improvement, (b) moderate to severe depression with rapid early improvement, and (c) mild to moderate depression with moderate early improvement. In contrast to the type of treatment, these differential patterns of early response (together with overall pre-treatment symptom severity) predicted outcomes (i.e. depression severity) at treatment termination and over the 1.5-year follow-up period.
  
  
  CONCLUSIONS
  Due to the small sample size and the controlled setting of this study the degree to which these results can be generalized to clinical practice has to be further investigated.
  
  
  CONCLUSIONS
  The findings provide further support for the assumption that early change is an important factor for the prediction of short- and long-term outcome in psychotherapy.
authors.affiliation: Clinical Psychology and Psychotherapy, Department of Psychology, University of Trier, D-54286 Trier, Germany. wolfgang.lutz@uni-trier.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Lutz
authors.forename: Niklaus
authors.initials: N
authors.lastname: Stulz
authors.forename: Katharina
authors.initials: K
authors.lastname: Köck
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003865:Major Depressive Disorder / Q000145:classification / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010343:Patient Admission; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics; D011613:Psychotherapy; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine