Tibialis anterior stretch reflex in early stance is suppressed by repetitive transcranial magnetic stimulation.
A rapid plantar flexion perturbation in the early stance phase of walking elicits a large stretch reflex in tibialis anterior (TA). In this study we use repetitive transcranial magnetic stimulation (rTMS) to test if this response is mediated through a transcortical pathway. TA stretch reflexes were elicited in the early stance phase of the step cycle during treadmill walking. Twenty minutes of 1 Hz rTMS at 115% resting motor threshold (MT(r)) significantly decreased (P < 0.05) the magnitude of the later component of the reflex at a latency of approximately 100 ms up to 25 min after the rTMS. Control experiments in which stretch reflexes were elicited during sitting showed no effect on the spinally mediated short and medium latency stretch reflexes (SLR and MLR) while the long latency stretch reflex (LLR) and the motor-evoked potential (MEP) showed a significant decrease 10 min after 115% MT(r) rTMS. This study demonstrates that 1 Hz rTMS applied to the leg area of the motor cortex can suppress the long latency TA stretch reflex during sitting and in the stance phase of walking. These results are in line with the hypothesis that the later component of the TA stretch reflex in the stance phase of walking is mediated by a transcortical pathway. An alternative explanation for the observed results is that the reflex is mediated by subcortical structures that are affected by the rTMS. This study also shows that rTMS may be used to study the neural control of walking.
Zuur
Abraham T
AT
Center for Sensory-Motor Interaction, Aalborg University, Fredrik Bajers Vej 7-D3, DK-9220 Aalborg, Denmark.
Christensen
Mark S
MS
Sinkjaer
Thomas
T
Grey
Michael J
MJ
Nielsen
Jens Bo
JB
D000328:Adult; D004576:Electromyography; D019054:Evoked Potentials, Motor / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D011187:Posture / Q000502:physiology*; D012026:Reflex, Stretch / Q000502:physiology*; D050781:Transcranial Magnetic Stimulation; D016138:Walking / Q000502:physiology; D055815:Young Adult