Cerebral perfusion abnormalities in children with autism and mental retardation: a segmental quantitative SPECT study.
Autism is a severe developmental disorder, the biological mechanisms of which remain unknown. Hence we conducted this study to assess the cerebral perfusion in 10 children with autism and mental retardation. Five age matched normal children served as controls. These cases were evaluated by single photon emission computed tomography (SPECT) using Tc-99m HMPAO, followed by segmental quantitative evaluation. Generalized hypoperfusion of brain was observed in all 10 cases as compared to controls. Frontal and prefrontal regions revealed maximum hypoperfusion. Subcortical areas also indicated hypoperfusion. We conclude that children with autism have varying levels of perfusion abnormities in brain causing neurophysiologic dysfunction that presents with cognitive and neuropsychological defects.
Gupta
Sunil Kumar
SK
Krishna Ram Ayurvigyan Shodh Sansthan, Anita Colony, Bajaj Nagar, Jaipur, and Vardhman Nuclear Medicine Centre, SDM Hospital, Jaipur, India. drskg@yahoo.com
Ratnam
B Venkat
BV
D001321:Autistic Disorder / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D054022:Cerebrum / Q000000981:diagnostic imaging / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008607:Intellectual Disability / Q000000981:diagnostic imaging*; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods