Polysaccharide-block-polypeptide copolymer vesicles: towards synthetic viral capsids.
Natural inspiration: Amphiphilic polysaccharide-block-polypeptide copolymers were synthesized by click chemistry from dextran end-functionalized with an alkyne group and poly(gamma-benzyl L-glutamate) end-functionalized with an azide group. The ability of these copolymers to self-assemble into small vesicles (see picture) suggests the possibility of a new generation of drug- and gene-delivery systems whose structure mimics that of viruses.
Schatz
Christophe
C
Université de Bordeaux, ENSCPB, 16 avenue Pey Berland, 33607 Pessac Cedex, France. schatz@enscpb.fr
Louguet
Stéphanie
S
Le Meins
Jean-François
JF
Lecommandoux
Sébastien
S
D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry; D002213:Capsid / Q000737:chemistry; D003911:Dextrans / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry; D018014:Gene Transfer Techniques; D010316:Particle Size; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011134:Polysaccharides / Q000138:chemical synthesis / Q000737:chemistry; D014780:Viruses / Q000737:chemistry
D001386:Azides; D003911:Dextrans; D004337:Drug Carriers; D010455:Peptides; D011108:Polymers; D011134:Polysaccharides; C540154:dextran-block-poly(-benzyl L-glutamate) copolymer; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid