title: Highly enantioselective zinc/amino alcohol-catalyzed alkynylation of aldehydes.
abstract: Meeting the challenge: The zinc/amino alcohol catalyzed enantioselective addition of terminal alkynes to aldehydes is effective with both phenylacetylene and methyl propiolate, leading to chiral secondary propargyl alcohols with very high enantioselectivity (see scheme).
authors.affiliation: Department of Applied Chemistry, China Agricultural University, Beijing, China.
authors.forename: Jiang-Chun
authors.initials: JC
authors.lastname: Zhong
authors.forename: Shi-Cong
authors.initials: SC
authors.lastname: Hou
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Bian
authors.forename: Min-Min
authors.initials: MM
authors.lastname: Yin
authors.forename: Ri-Song
authors.initials: RS
authors.lastname: Na
authors.forename: Bing
authors.initials: B
authors.lastname: Zheng
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Li
authors.forename: Shang-Zhong
authors.initials: SZ
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Wang
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003521:Cyclopropanes / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D020005:Propanols / Q000138:chemical synthesis*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000480:Alkynes; D000605:Amino Alcohols; D003521:Cyclopropanes; D020005:Propanols; C028255:propargyl alcohol; D015032:Zinc