title: Colon adenocarcinoma and solitary tibia metastasis: rare entity.
abstract: BACKGROUND
  Colorectal cancer is the third leading cause of cancer-related deaths in the world. Mostly, death occurs with complications of distant metastases.
  
  
  CONCLUSIONS
  Effective systemic chemotherapy regimen and resultant improved survival for patients are associated with an increased incidence of metastases at uncommon sites. Therefore, incidences of osseous metastases are rising at the last decade. Osseous metastases are mostly diffuse, along with visceral metastases.
  
  
  CONCLUSIONS
  Most common osseous metastatic sites are lumbal, sacral vertebrae, and pelvis region, probably because of colonic anatomical proximity to the paravertebral venous plexus. Herein, we report an uncommon case of isolated solitary tibia metastasis in the colorectal cancer patient and management of disease course.
authors.affiliation: Department of Medical Oncology, Baskent University Faculty of Medicine, Ankara, Turkey. fatihkose@gmail.com
authors.forename: F
authors.initials: F
authors.lastname: Kose
authors.forename: H
authors.initials: H
authors.lastname: Sakalli
authors.forename: A
authors.initials: A
authors.lastname: Sezer
authors.forename: H
authors.initials: H
authors.lastname: Mertsoylu
authors.forename: A
authors.initials: A
authors.lastname: Pourbagher
authors.forename: M
authors.initials: M
authors.lastname: Reyhan
authors.forename: O
authors.initials: O
authors.lastname: Ozyilkan
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary*; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D013977:Tibia / Q000473:pathology*; D014057:Tomography, X-Ray Computed