[Efficacy of immunoadsorbent treatment in experimental allergic encephalomyelitis].
Hemoperfusion through the granulated hemoadsorbent SCN, fibrous carbonic adsorbent AUVM and immunoadsorbent (SCN with immobilized MBP) was applied for the treatment of experimental allergic encephalomyelitis (EAE) in guinea pigs. EAE was induced by single subcutaneous injection of 100 microg of MBP in complete Freund's adjuvant. Hemoperfusion was performed on the stage of EAE manifestation or in latent period. It was found that immunoadsorbent has the highest therapeutic efficacy and allows to eliminate up to 32% anti-MBP antibodies from the serum of guinea pigs with EAE, has up to 84% and 90% of adsorptive capacity of small and middle weight endogenous substances, respectively, and reduces the level of metabolites with molecular weight less than 30 kDa in blood plasma up to 36%.
Hurina
N M
NM
Bardakhivs'ka
K I
KI
Kuchmerovs'ka
T M
TM
D000818:Animals; D001323:Autoantibodies / Q000097:blood / Q000302:isolation & purification; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D005260:Female; D006168:Guinea Pigs; D006464:Hemoperfusion / Q000295:instrumentation / Q000379:methods*; D007164:Immunosorbents / Q000737:chemistry / Q000276:immunology; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D016896:Treatment Outcome
D001323:Autoantibodies; D007164:Immunosorbents; D004676:Myelin Basic Protein; D010047:Ovalbumin