[Primary study on the hepatotoxicity and nephrotoxicity of rats induced by three kinds of nanomaterials].
OBJECTIVE
To investigate the effects of hepatotoxicity and nephrotoxicity on rats induced by Nano-SiO2 Nano-Fe3O4 and SWCNTs.


METHODS
42 Wistar rats were randomly divided into the control group, low and high dose groups of three kinds of nanoparticles. The rats were killed when rats were exposed by oral gavage for 4 weeks. The ratios of liver and kidney to body weight, the pathological changes of liver and kidney, serum certain biochemically indexes were detected.


RESULTS
The ratios of liver and kidney to body weight in experimental groups were not significantly difference in comparison to the control. The ALT and AST level in serum of rats in part experiment groups were more higher than those of the control group. The results of pathological analysis indicated that there were small amounts inflammatory cell infiltration and hepatic cell adipose degeneration in the liver of rats in high-dose group, the change of kidney were not found.


CONCLUSIONS
Three kinds of nanoparticles could induce hepatotoxicity of the rats in the condition of this experiment.
Lin
Bencheng
B
Institute of Health and Environmental Medicine, Academy of Military Medical Sciences, Tianjin 300050, China. bencheng1236@163.com
Xi
Zhuge
Z
Zhang
Yingge
Y
Zhang
Huashan
H
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D052203:Ferrosoferric Oxide / Q000633:toxicity; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D053768:Metal Nanoparticles / Q000633:toxicity*; D037742:Nanotubes, Carbon / Q000633:toxicity; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012822:Silicon Dioxide / Q000633:toxicity
D037742:Nanotubes, Carbon; D012822:Silicon Dioxide; D052203:Ferrosoferric Oxide