Relation of resistin levels with cardiovascular risk factors and insulin resistance in non-diabetes obese patients.
BACKGROUND
The aim of the present study was to explore the relationship of resistin levels with these above mentioned factors.


METHODS
A population of 213 obese was analyzed. A complete nutritional and biochemical evaluation was performed.


RESULTS
The mean age was 45.1+16.7 years, the mean BMI was 35.6+5.7. Higher weight, fat mass, fat free mass, waist to hip ratio, RMR, insulin and HOMA levels were observed in men than women. In all group, the analysis with a dependent variable (resistin) showed that fat mass remained in the model (F=2.48; p<0.05), with an increase of 0.033 ng/ml (CI 95%: 0.011-0.055) with each 1 kg of fat mass and a decrease of -0.29 ng/ml (CI 95%: -0.53, -0.01) with each mmHg of diastolic blood pressure. In a second model (only women) (resistin), fat mass remained in the model (F=6.06; p<0.05), with an increase of 0.037 ng/ml (CI 95%: 0.015, 0.06) with each kg of fat mass and a decrease of -0.032 ng/ml (CI 95%: -0.054, -0.01) with each mmHg of diastolic blood pressure. The third multivariate analysis (only men) did not show any relation among resistin levels and other parameters.


CONCLUSIONS
Resistin levels are related with different cardiovascular risk and anthropometric parameters, without relation with insulin resistance. A sex interaction has been observed.
de Luis
D A
DA
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, RD-056/0013 RETICEF, University of Valladolid, C/Los perales 16, Simancas 47130, Valladolid, Spain. dadluis@yahoo.es
Gonzalez Sagrado
M
M
Conde
R
R
Aller
R
R
Izaola
O
O
Perez Castrillon
J L
JL
Dueñas
A
A
D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003971:Diastole; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D011446:Prospective Studies; D052243:Resistin / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D052243:Resistin; D014280:Triglycerides; D002784:Cholesterol