title: Candida albicans triggers proliferation and differentiation of hematopoietic stem and progenitor cells by a MyD88-dependent signaling.
abstract: As TLRs are expressed by hematopoietic stem and progenitor cells, these receptors may play a role in hematopoiesis in response to pathogens during infection. We showed here that inactivated yeasts and hyphae of Candida albicans induce in vitro the proliferation of purified murine hematopoietic stem and progenitor cells (Lin(-)c-Kit(+) Sca-1(+)) as well as their differentiation to lineage positive cells, through a MyD88-dependent pathway. These results indicate that TLR-mediated recognition of C. albicans by hematopoietic stem and progenitor cells may augment the host capability for rapidly replenishing the innate immune system during candidiasis.
authors.affiliation: Departamento de Microbiología y Ecología, Universitat de València, Burjassot, Spain.
authors.forename: Alberto
authors.initials: A
authors.lastname: Yáñez
authors.forename: Celia
authors.initials: C
authors.lastname: Murciano
authors.forename: José-Enrique
authors.initials: JE
authors.lastname: O'Connor
authors.forename: Daniel
authors.initials: D
authors.lastname: Gozalbo
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Gil
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000502:physiology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D053594:Myeloid Differentiation Factor 88 / Q000378:metabolism*; D013234:Stem Cells / Q000502:physiology*
chemical_list: C507780:Myd88 protein, mouse; D053594:Myeloid Differentiation Factor 88