Regulation of B-cell proliferation and differentiation by pre-B-cell receptor signalling.
The pre-B-cell receptor (pre-BCR) is expressed following the productive recombination of the immunoglobulin heavy chain gene. Signals through the pre-BCR are required for initiating diverse processes in pre-B cells, including proliferation and recombination of the light chain gene, which eventually lead to the differentiation of pre-B cells to immature B cells. However, the molecular mechanisms by which the pre-BCR promotes these processes remain largely unresolved. Recent findings suggest that forkhead box O (FOXO) transcription factors connect pre-BCR signalling to the activation of the recombination machinery. In this Review, we discuss how FOXO transcription factors are regulated by the pre-BCR to allow the progression of the cell cycle and the recombination of the light chain gene.
Herzog
Sebastian
S
Centre for Biological Signalling Studies, Albert-Ludwigs-Universität Freiburg, Freiburg, Germany.
Reth
Michael
M
Jumaa
Hassan
H
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002455:Cell Division; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D038041:Lymphopoiesis / Q000276:immunology*; D054420:Pre-B Cell Receptors / Q000378:metabolism*; D011995:Recombination, Genetic; D015398:Signal Transduction
D051858:Forkhead Transcription Factors; D007147:Immunoglobulin Light Chains; D054420:Pre-B Cell Receptors