Understanding and testing risk mechanisms for mental disorders.
Over the past 50 years there has been a virtual revolution in thinking about risk mechanisms. The key areas of challenge and opportunity include: identification of environmental causes; use of natural experiments; gene-environment interaction; testing for mediation; developmental moderation; biological programming; and developmental perturbations.
Rutter
Michael
M
Institute of Psychiatry, London, UK. j.wickham@iop.kcl.ac.uk
D002648:Child; D004777:Environment; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D012307:Risk Factors