The new salicylate derivative UR-1505 modulates the Th2/humoral response in a dextran sodium sulphate model of colitis that resembles ulcerative colitis.
The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2/humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-1505 (300 microM) inhibited both the production of interleukin (IL)-10 and IL-5 in concanavalin A (Con A)-activated splenocytes and the production of immunoglobulin (Ig) G and IgA by B-lymphocytes. However, in contrast to the in vitro results, the administration of UR-1505 (10 and 30 mg/kg per day) to rats with established DSS-colitis enhanced both IL-10 and IgA production, whereas it inhibited IgG production, thus ameliorating the intestinal inflammation.
Bailón
Elvira
E
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Department of Pharmacology, School of Pharmacy, University of Granada, Spain.
Román
Juan
J
Ramis
Isabel
I
Michelena
Pedro
P
Balsa
Dolors
D
Merlos
Manuel
M
Zarzuelo
Antonio
A
Gálvez
Julio
J
Comalada
Mònica
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D003093:Colitis, Ulcerative / Q000188:drug therapy / Q000276:immunology; D003106:Colon / Q000378:metabolism; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000378:metabolism; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D007070:Immunoglobulin A / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D051381:Rats; D012459:Salicylates / Q000627:therapeutic use*; D018418:Th2 Cells / Q000276:immunology*; D005466:Fluorocarbons
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D016264:Dextran Sulfate; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012459:Salicylates; C522458:2-hydroxy-4-(2,2,3,3,3-pentafluoropropoxy)benzoic acid; D005466:Fluorocarbons