title: A ratiometric fluorescent sensor with a large Stokes shift for imaging zinc ions in living cells.
abstract: The ratiometric fluorescent sensor based on furoquinoline has been designed and synthesized, and not only exhibits a large Stokes shift of 199 nm in a mixture of C(2)H(5)OH-H(2)O (v/v = 8 ratio 2, 10 mM Tris-HCl, pH = 7.3), but can selectively detect zinc ions in the presence of competing metal ions with a red-shift of 75 nm; moreover, cell stain experiments show that can readily reveal a change in intracellular Zn(2+).
authors.affiliation: Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Xue
authors.forename: Chun
authors.initials: C
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D002460:Cell Line; D005456:Fluorescent Dyes / Q000737:chemistry*; D005663:Furans / Q000737:chemistry*; D051379:Mice; D018613:Microscopy, Confocal; D041681:NIH 3T3 Cells; D011725:Pyridines / Q000737:chemistry*; D011804:Quinolines / Q000737:chemistry*; D015032:Zinc / Q000032:analysis* / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D005663:Furans; D011725:Pyridines; D011804:Quinolines; C037219:quinoline; D015032:Zinc