title: Synthesis of (-)-lobeline via enzymatic desymmetrization of lobelanidine.
abstract: The bioactive alkaloid (-)-lobeline was synthesized via the stereoselective acylation (desymmetrization) of meso-lobelanidine by vinyl acetate in the presence of Candida antarctica lipase B.
authors.affiliation: Département de Chimie, PROTEO, Faculté des Sciences et de Génie, Université Laval, Québec, Canada. robert.chenevert@chm.ulaval.ca
authors.forename: Robert
authors.initials: R
authors.lastname: Chênevert
authors.forename: Pierre
authors.initials: P
authors.lastname: Morin
mesh_terms: D055162:Biocatalysis; D005656:Fungal Proteins; D008049:Lipase / Q000737:chemistry; D008120:Lobeline / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D005656:Fungal Proteins; D008120:Lobeline; D008049:Lipase; C431349:lipase B, Candida antarctica; C540737:lobelanidine