title: The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila.
abstract: We have characterized the gene emperor's thumb (et) and showed that it is required for the regulation of apoptosis in Drosophila. Loss-of-function mutations in et result in apoptosis associated with a decrease in the concentration of DIAP1. Overexpression of one form of et inhibits apoptosis, consistent with et having an anti-apoptotic function; however, overexpression of a second form of et induces apoptosis, indicating that the two forms of et may have competing functions. et encodes a protein deubiquitinase, suggesting it regulates apoptosis by controlling the stability of apoptotic regulatory proteins.
authors.affiliation: Department of Molecular Cell and Developmental Biology, and Molecular Biology Institute, University of California at Los Angeles, Los Angeles, CA 90095, USA.
authors.forename: Jeronimo P
authors.initials: JP
authors.lastname: Ribaya
authors.forename: Madhuka
authors.initials: M
authors.lastname: Ranmuthu
authors.forename: Jeff
authors.initials: J
authors.lastname: Copeland
authors.forename: Sergey
authors.initials: S
authors.lastname: Boyarskiy
authors.forename: Adrienne P
authors.initials: AP
authors.lastname: Blair
authors.forename: Bruce
authors.initials: B
authors.lastname: Hay
authors.forename: Frank A
authors.initials: FA
authors.lastname: Laski
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000502:physiology*; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000502:physiology*; D010450:Endopeptidases / Q000502:physiology*; D017344:Genes, Insect; D008954:Models, Biological; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D017386:Sequence Homology, Amino Acid; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism
chemical_list: D051017:Apoptosis Regulatory Proteins; D029721:Drosophila Proteins; D044767:Ubiquitin-Protein Ligases; D010450:Endopeptidases; C534688:ubiquitin specific protease 36, Drosophila