title: Lower urinary tract symptoms after hormone replacement therapy in Japanese patients with late-onset hypogonadism: a preliminary report.
abstract: Hormone replacement therapy (HRT) is performed for the treatment for patients with late onset hypogonadism (LOH). One of the main concerns about HRT is the influence of lower urinary tract including prostate. This study examined whether HRT for Japanese patients of LOH affected lower urinary tract symptoms. A total of 21 patients with LOH were included in this study. Changes of International prostate symptom score (IPSS), IPSS quality of life (QOL) index and King's health questionnaire (KHQ), before HRT and 3 months after HRT, were evaluated. Statistical comparisons were made using the Wilcoxon signed rank test, P < 0.05 was considered statistically significant. Total IPSS and QOL index were not significantly different from 7.43 +/- 6.56, 2.71 +/- 1.74 at baseline to 8.29 +/- 6.24, 2.91 +/- 1.13 after 3 months. There were no significant differences in any of the nine categories of KHQ. In this preliminary study, the results suggested that HRT for LOH had no short-term effects on patients with lower urinary symptoms.
authors.affiliation: Department of Urology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takao
authors.forename: Akira
authors.initials: A
authors.lastname: Tsujimura
authors.forename: Jiro
authors.initials: J
authors.lastname: Nakayama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Miyagawa
authors.forename: Shingo
authors.initials: S
authors.lastname: Takada
authors.forename: Norio
authors.initials: N
authors.lastname: Nonomura
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okuyama
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014555:Urination Disorders / Q000188:drug therapy / Q000209:etiology*
chemical_list: D006063:Chorionic Gonadotropin; D013739:Testosterone; C004648:testosterone enanthate