Plasma and tissue oxidative stress index in patients with rheumatic and degenerative heart valve disease.
OBJECTIVE
We investigated whether patients with rheumatic and degenerative heart valve disease (HVD) differed with regard to plasma and tissue oxidative stress index (OSI).


METHODS
The study included 56 patients who underwent valve replacement due to rheumatic (n=32; 15 males; mean age 47+/-10 years) and degenerative (n=24; 13 males; mean age 55+/-12 years) HVD. Plasma and tissue total oxidative status (TOS) and total antioxidative capacity (TAC) levels were measured and OSI was calculated.


RESULTS
Patients with degenerative HVD had significantly higher age, increased interventricular septum thickness, and higher frequency of aortic stenosis, whereas the incidence of mitral stenosis was higher in patients with rheumatic HVD (p<0.05). Plasma oxidative characteristics did not differ between the two HVD groups (p>0.05). Tissue TAC was significantly lower in patients with rheumatic HVD (p=0.027), whereas tissue TOS and OSI were similar between the two HVD groups (p>0.05). In bivariate analysis, plasma OSI did not show any correlation with clinical, laboratory, and echocardiographic variables (p>0.05).


CONCLUSIONS
Our data show that plasma and tissue OSI levels are similar in patients with rheumatic and degenerative HVD.
Rabus
Murat
M
Department of Cardiovascular Surgery, Kartal Koşuyolu Heart and Research Hospital, Istanbul, Turkey. muratrabus@yahoo.com
Demirbağ
Recep
R
Sezen
Yusuf
Y
Konukoğlu
Oğuz
O
Yildiz
Ali
A
Erel
Ozcan
O
Zeybek
Rahmi
R
Yakut
Cevat
C
D000367:Age Factors; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers; D004452:Echocardiography; D005260:Female; D006349:Heart Valve Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D012214:Rheumatic Heart Disease / Q000378:metabolism* / Q000473:pathology; D012307:Risk Factors; D012720:Severity of Illness Index
D000975:Antioxidants; D015415:Biomarkers