title: Successful treatment with Protein C of febrile neutropenia in pediatric patients during cancer therapy.
abstract: Febrile Neutropenia (FN) is a complication of chemotherapy in childhood cancer and at the same time secondary deficit of Protein C (PC) is often present during sepsis in children with cancer. In this study we have compared the clinical outcome of two different groups. At the onset of FN during chemotherapy the first group (patients with a secondary deficit of PC) received Protein C Concentrate (PCC) replacement while the other group without PC deficiency received only symptomatic therapies. We report that PC replacement could shorten duration of FN and improve the clinical outcome. The administration of PCC was safe and without any complications.
authors.affiliation: Department of Biomedicine of Development Age, University of Bari, Bari, Italy. giordano@bioetaev.uniba.it
authors.forename: Paola
authors.initials: P
authors.lastname: Giordano
authors.forename: Valerio
authors.initials: V
authors.lastname: Cecinati
authors.forename: Giovanni Carlo
authors.initials: GC
authors.lastname: Delvecchio
authors.forename: Giampaolo
authors.initials: G
authors.lastname: Arcamone
authors.forename: Francesco
authors.initials: F
authors.lastname: De Leonardis
authors.forename: Massimo
authors.initials: M
authors.lastname: Grassi
authors.forename: Letizia Pomponia
authors.initials: LP
authors.lastname: Brescia
authors.forename: Nicola
authors.initials: N
authors.lastname: Santoro
authors.forename: Domenico
authors.initials: D
authors.lastname: De Mattia
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007938:Leukemia / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy*; D011486:Protein C / Q000627:therapeutic use*; D012509:Sarcoma / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D011486:Protein C