title: Describing chemical transformations in multiple spiking isotope dilution: fundamental aspects and definitions.
abstract: Currently, several mathematical methods exist to address simultaneous species formation and degradation using multiple spiking isotope dilution mass spectrometry. While all of these strategies have been compared numerically, comparison of the underlying principles is lacking. Owing to recent interest in using the species inter-conversion factors, mainly to study the quality of analytical methods, this manuscript reviews the mathematical logic and inconsistencies of the existing double or triple spiking isotope dilution models. Systematic terminology is also introduced to clarify the species inter-conversion coefficient definitions.
authors.affiliation: Institute for National Measurement Standards, National Research Council Canada, 1200 Montreal Rd. M-12, Ottawa, ON, CanadaK1A 0R6. juris.meija@nrc.ca
authors.forename: Juris
authors.initials: J
authors.lastname: Meija
authors.forename: Laurent
authors.initials: L
authors.lastname: Ouerdane
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Mester