The effect of oral and IV ramosetron on postoperative nausea and vomiting in patients undergoing gynecological laparoscopy with total intravenous anesthesia.
OBJECTIVE
Ramosetron can be administered orally as well as intravenously. We investigated the effect of oral ramosetron on postoperative nausea and vomiting (PONV) in patients undergoing gynecological laparoscopy.


METHODS
One hundred and twenty women were allocated randomly to one of three groups (n = 40 in each) to receive saline (control), 0.1 mg oral ramosetron (PO), or 0.3 mg IV ramosetron (IV). Total intravenous anesthesia (TIVA) with propofol and remifentanil was used in all patients.


RESULTS
The incidence of complete response (no PONV, no rescue) in the control, IV, and PO groups was: 65%, 90%, and 87.5%, respectively, during the first 1 h; and 67.5%, 87.5%, and 80%, respectively, during 1 to 24 h.


CONCLUSIONS
The effect of oral ramosetron 0.1 mg was comparable to that of IV ramosetron 0.3 mg on the prevention of PONV in women undergoing gynecological laparoscopy with TIVA. Both the oral and IV forms were effective at preventing PONV during the first 1 h after surgery.
Lee
Dongchul
D
Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Korea.
Kim
Ji Young
JY
Shin
Jin Woo
JW
Ku
Chun Hoe
CH
Park
Yeon Soo
YS
Kwak
Hyun Jeong
HJ
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D006993:Hypnotics and Sedatives; D007275:Injections, Intravenous; D010535:Laparoscopy; D008874:Midazolam; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011292:Premedication; D055815:Young Adult
D000932:Antiemetics; D001562:Benzimidazoles; D006993:Hypnotics and Sedatives; C071315:ramosetron; D008874:Midazolam