title: Silver-ion-mediated DNAzyme switch for the ultrasensitive and selective colorimetric detection of aqueous Ag+ and cysteine.
abstract: Two states, two applications! An Ag(+)-mediated DNAzyme switch has been designed to detect Ag(+) and cysteine with high sensitivity and selectivity. In the closed state, Ag(+) turns on the switch through the formation of cytosine-Ag(+)-cytosine base pairs, whereas adding cysteine turns off the open switch because it competitively binds to Ag(+). This feature endows the DNAzyme switch with two sensing applications.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Lili
authors.initials: L
authors.lastname: Shi
authors.forename: Erkang
authors.initials: E
authors.lastname: Wang
authors.forename: Shaojun
authors.initials: S
authors.lastname: Dong
mesh_terms: D002412:Cations; D003124:Colorimetry; D003545:Cysteine / Q000032:analysis*; D021881:DNA, Catalytic / Q000737:chemistry*; D054856:G-Quadruplexes; D006861:Hydrogen Peroxide / Q000737:chemistry; D012834:Silver / Q000032:analysis / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002412:Cations; D021881:DNA, Catalytic; D012834:Silver; D006861:Hydrogen Peroxide; D003545:Cysteine