title: Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis.
abstract: Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis.
authors.affiliation: Department of Cell Biology and Cell Engineering Research Center and State Key Laboratory of Cancer Biology, Fourth Military Medical University, 17 West Changle Street, Xi'an 710032, China.
authors.forename: Yanke
authors.initials: Y
authors.lastname: Chen
authors.forename: Hongxin
authors.initials: H
authors.lastname: Zhang
authors.forename: Xingchun
authors.initials: X
authors.lastname: Gou
authors.forename: Yohei
authors.initials: Y
authors.lastname: Horikawa
authors.forename: Jinliang
authors.initials: J
authors.lastname: Xing
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Chen
mesh_terms: D015703:Antigens, CD / Q000235:genetics; D051926:Basigin / Q000235:genetics*; D002465:Cell Movement; D004730:Endothelium, Vascular / Q000166:cytology / Q000502:physiology*; D005434:Flow Cytometry; D006801:Humans; D020287:In Situ Nick-End Labeling; D009369:Neoplasms / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics; D018919:Neovascularization, Physiologic / Q000235:genetics*; D034741:RNA, Small Interfering / Q000235:genetics; D014471:Umbilical Veins / Q000166:cytology / Q000502:physiology*; D015854:Up-Regulation
chemical_list: D015703:Antigens, CD; C497886:BSG protein, human; D034741:RNA, Small Interfering; D051926:Basigin