[Preparation of Zhongjiefeng dispersible tablets].
OBJECTIVE
To prepare Zhongjiefeng dispersible tablets.


METHODS
The formulation of Zhongjiefeng dispersible tablets were optimized as index of disintegration time by orthogonal design test.


RESULTS
The optimized Zhongjiefeng dispersible tablets, which were prepared by selecting 16% PVPP and 3% L-HPC as disintegrants, 40% MCC as filler, can disintegrate in 3 mins.


CONCLUSIONS
The above formulation is reasonable and the disintegration time is suitable, so it can provide theoretic support for industrialization.
Wu
Zhen-Feng
ZF
Institute of Materia Medica, Guangdong Pharmaceutical University/Guangdong Key Laboratory of Advanced Drug Delivery, Guangzhou 510006, China. zfwu527@163.com
He
Wei
W
Li
Yong
Y
D002482:Cellulose / Q000008:administration & dosage / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry; D019684:Magnoliopsida / Q000737:chemistry*; D010592:Pharmaceutic Aids / Q000008:administration & dosage* / Q000737:chemistry / Q000145:classification; D010946:Plants, Medicinal / Q000737:chemistry; D011205:Povidone / Q000008:administration & dosage / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors
D004365:Drugs, Chinese Herbal; D010592:Pharmaceutic Aids; D013607:Tablets; D002482:Cellulose; D011205:Povidone