New alkaloids from Corydalis species.
A new alkaloid, chaerophylline (1), together with known alkaloids (-)-corypalmine, berberine chloride, (-)-isocorypalmine, (-)-corydalmine and (+)-bicuculline have been isolated from the crude base fraction of Corydalis chaerophylla. The crude base fractions of Corydalis longipes gave a new alkaloid, longicine (4), together with known alkaloids (+/-)-alpha-hydrastine, (+/-)-beta-hydrastine, N-methylhydrasteine hydroxylactam, 1-methoxyberberine chloride and berberinium hydroxide. These alkaloids are reported for the first time from the above species and their structures were established by chemical and spectroscopic evidence.
Jha
R N
RN
Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Pandey
M B
MB
Singh
A K
AK
Singh
S
S
Singh
V P
VP
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D001599:Berberine / Q000031:analogs & derivatives / Q000737:chemistry; D001640:Bicuculline / Q000737:chemistry; D031311:Corydalis / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*
D000470:Alkaloids; D006576:Heterocyclic Compounds, 4 or More Rings; D010936:Plant Extracts; D001599:Berberine; C115958:berberrubine; C471057:corypalmine; D001640:Bicuculline