Turnabout is fair play: T cell stimulation by dendritic cell-expressed CD40L.
CD40L expressed on T cells plays an important role in stimulating the function of dendritic cells (DCs). In this issue of Immunity, Johnson et al. (2009) demonstrate a role for DC-expressed CD40L in priming CD8(+) T cell responses.
Tough
David F
DF
Immuno-Inflammation Centre of Excellence in Drug Discovery, GlaxoSmithKline, Gunnels Wood Road, Stevenage, UK. david.f.tough@gsk.com
D000818:Animals; D023201:CD40 Ligand / Q000276:immunology* / Q000378:metabolism*; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D023201:CD40 Ligand