title: Neuropilins, semaphorins, and their role in thymocyte development.
abstract: Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.
authors.affiliation: Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. daniella@ioc.fiocruz.br
authors.forename: Daniella Arêas
authors.initials: DA
authors.lastname: Mendes-da-Cruz
authors.forename: Yves
authors.initials: Y
authors.lastname: Lepelletier
authors.forename: Anne C
authors.initials: AC
authors.lastname: Brignier
authors.forename: Salete
authors.initials: S
authors.lastname: Smaniotto
authors.forename: Amédée
authors.initials: A
authors.lastname: Renand
authors.forename: Pierre
authors.initials: P
authors.lastname: Milpied
authors.forename: Mireille
authors.initials: M
authors.lastname: Dardenne
authors.forename: Olivier
authors.initials: O
authors.lastname: Hermine
authors.forename: Wilson
authors.initials: W
authors.lastname: Savino
mesh_terms: D000818:Animals; D002465:Cell Movement; D006801:Humans; D009420:Nervous System / Q000378:metabolism; D039921:Neuropilins / Q000378:metabolism*; D039961:Semaphorins / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism* / Q000473:pathology
chemical_list: D039921:Neuropilins; D039961:Semaphorins