The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling.
Eradicating hedgehogs: The title molecule has been previously identified as a potent inhibitor of the Hedgehog signaling pathway, which gives embryonic cells information needed to develop properly. This molecule is shown to modulate Hedgehog target gene expression by depolymerizing microtubules, thus revealing dual roles of the cytoskeleton in pathway regulation (see figure).
Cupido
Tommaso
T
Department of Chemical and Systems Biology, Stanford University School of Medicine, 269 Campus Drive, Stanford, CA 94305-5174, USA.
Rack
Paul G
PG
Firestone
Ari J
AJ
Hyman
Joel M
JM
Han
Kyuho
K
Sinha
Surajit
S
Ocasio
Cory A
CA
Chen
James K
JK
D000818:Animals; D002460:Cell Line; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006574:Heterocyclic Compounds, 2-Ring / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008870:Microtubules / Q000187:drug effects / Q000378:metabolism*; D041681:NIH 3T3 Cells; D011725:Pyridines / Q000737:chemistry; D015398:Signal Transduction; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology*
D053823:Hedgehog Proteins; D006574:Heterocyclic Compounds, 2-Ring; C525593:JK184; D011725:Pyridines; D013844:Thiazoles; C023666:pyridine