title: Thin-section CT of the mediastinum in preoperative N-staging of non-small cell lung cancer: comparison with FDG PET.
abstract: OBJECTIVE
  To compare diagnostic capability of preoperative N-staging of lung cancer between thin-section CT of the mediastinum and FDG PET, and 5mm slice thickness CT.
  
  
  METHODS
  The subjects were 34 patients with lung carcinoma who were examined by both CT and PET, and subsequently underwent surgery between May 2005 and January 2007. CT was carried out with a 16 detector row helical CT scanner. The raw data were reconstructed into 5 mm slice thickness and 1mm slice thickness (thin-section CT). A total of 251 lymph node stations were retrospectively assessed for the presence of lymph node metastasis with thin-section CT, 5 mm CT and PET. In the interpretations of thin-section CT and 5 mm CT, we employed multi-criteria as follows: nodular calcification and intranodal fat as benign criteria, and short-axis diameter more than 10 mm (size criterion), focal low density other than fat, surrounding fat infiltration and convex margin in hilar lymph nodes, as malignant criteria. On PET, maximum standardized uptake value (SUVmax) of 2.5 or more was used as the criterion of malignancy. Sensitivity and specificity were compared between these examinations using McNemar test.
  
  
  RESULTS
  Sensitivities and specificities of thin-section CT, 5 mm CT and PET were 25%, 25%, 25%, and 97%, 94%, 98%, respectively. The statistical analysis revealed that the specificity of 5 mm CT was significantly lower than those of thin-section CT (p=0.039) and PET (p=0.006), while no difference was present between thin-section CT and PET.
  
  
  CONCLUSIONS
  Thin-section CT of the mediastinum using multiple criteria was comparable to PET in preoperative N-staging of lung cancer.
authors.affiliation: Department of Radiology, University of Yamanashi, Shimokawato, Chuo-shi, Yamanashi Prefecture, Japan. nambu-a@gray.plala.or.jp
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nambu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kato
authors.forename: Utaroh
authors.initials: U
authors.lastname: Motosugi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Araki
authors.forename: Hideto
authors.initials: H
authors.lastname: Okuwaki
authors.forename: Keiichi
authors.initials: K
authors.lastname: Nishikawa
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Saito
authors.forename: Keiko
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Ichikawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D003287:Contrast Media; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007472:Iohexol; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008482:Mediastinum / Q000000981:diagnostic imaging* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D011857:Radiographic Image Interpretation, Computer-Assisted; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D036542:Tomography, Spiral Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D007472:Iohexol