Synaptic vesicle endocytosis: get two for the price of one?
Tight coupling between synaptic vesicle exocytosis and endocytosis is critical for the maintenance of neurotransmission. In this issue of Neuron, Zhu et al. reveal a surprising facet of this coupling by showing that, at low frequencies, fusion of a single vesicle leads to retrieval of two vesicles with dissimilar attributes.
Chung
Chihye
C
Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
Kavalali
Ege T
ET
D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D004705:Endocytosis / Q000502:physiology*; D005456:Fluorescent Dyes; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D013194:Staining and Labeling / Q000379:methods; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism* / Q000648:ultrastructure
D005456:Fluorescent Dyes; D009419:Nerve Tissue Proteins