Properties of an oral preparation containing a chitosan salt.
The 2-(4-chlorophenoxy)-2-methylpropionic acid (CMP) salt of chitosan (CS), CS-CMP, and that of a CS derivative (CP), were prepared and their ability to adsorb bile acids investigated. CS-CMP and CP-CMP rapidly adsorbed taurocholate (TCA) and glycocholate (GCA) when these bile acids were present together in the medium, with simultaneous release of CMP. A secondary bile acid, taurodeoxycholate, was preferentially adsorbed over TCA and GCA. Alginate gel beads containing CS-CMP did not differ from CS-CMP alone in their manner of bile acids take up. Furthermore, oral administration of CS-CMP to rats resulted in decreased serum cholesterol and triacylglycerol levels for two weeks. Therefore, CS-CMP, as well as a vehicle containing CS-CMP, might be a useful agent with which to treat hyperlipidemia.
Murata
Yoshifumi
Y
Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan. y-murata@hokuriku-u.ac.jp
Kodama
Youko
Y
Hirai
Daijirou
D
Kofuji
Kyouko
K
Kawashima
Susumu
S
D000284:Administration, Oral; D000327:Adsorption; D000464:Alginates / Q000737:chemistry; D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D002784:Cholesterol / Q000378:metabolism; D004032:Diet; D004435:Eating; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D008297:Male; D015394:Molecular Structure; D011422:Propionates / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D012492:Salts / Q000737:chemistry*; D055672:Static Electricity; D014280:Triglycerides / Q000737:chemistry
D000464:Alginates; D001647:Bile Acids and Salts; D006603:Hexuronic Acids; D011422:Propionates; D012492:Salts; D014280:Triglycerides; D020723:Glucuronic Acid; D048271:Chitosan; D002784:Cholesterol