title: PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes.
abstract: The PLATINUM (Protein-Ligand ATtractions Investigation NUMerically) web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures. Furthermore, PLATINUM provides a number of tools for quantitative characterization of the hydrophobic/hydrophilic match in biomolecular complexes e.g. in docking poses. These complement standard scoring functions. The calculations are based on the concept of empirical Molecular Hydrophobicity Potential (MHP).
  
  
  BACKGROUND
  The PLATINUM web tool as well as detailed documentation and tutorial are available free of charge for academic users at http://model.nmr.ru/platinum/. PLATINUM requires Java 5 or higher and Adobe Flash Player 9.
  
  
  BACKGROUND
  Supplementary data are available at Bioinformatics online.
authors.affiliation: M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 GSP, Moscow V-437, Russia. pyrkov@nmr.ru
authors.forename: Timothy V
authors.initials: TV
authors.lastname: Pyrkov
authors.forename: Anton O
authors.initials: AO
authors.lastname: Chugunov
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Krylov
authors.forename: Dmitry E
authors.initials: DE
authors.lastname: Nolde
authors.forename: Roman G
authors.initials: RG
authors.lastname: Efremov
mesh_terms: D001665:Binding Sites; D030562:Databases, Protein; D057927:Hydrophobic and Hydrophilic Interactions; D020407:Internet; D008024:Ligands; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012984:Software
chemical_list: D008024:Ligands; D011506:Proteins