Exploration of the cytotoxic effects of an insecticide, lambda cyhalothrine, on sexual exocrine function in the white rat.
Many xenobiotiques (solvents, pesticides, metals heavy.....) are suspected to be responsible for the fall of the male and female fertility. The purpose of this work is to study the insecticide impact, Lambda-cyhalothrine, managed by oral way during 7 days on the rat testicles histology. Wistar rats were given distilled water (controls) or containing 15,383 mg/kg or 23,075 mg/kg of Lambda-cyhalothrine. The exposure to this insecticide induced an increase in the diameters of the seminiferous tubes. The histological of the seminiferous tubes revealed deteriorations of the germinatif epithelium: blocking of the spermatogenesis, presence of the apoptotic cells and absence of the spermatozoids in certain lumens. All these histological alterations constitute a signs of cytotoxicity of Lambda-cyhalothrine on the male fertility in the Wistar rat.
Lebaili
N
N
Department of biology, Ecole Normale Supérieure de Kouba, Algeria. nlebaili@yahoo.fr
Saadi
L
L
Mosbah
R
R
Mechri
N
N
D000818:Animals; D005298:Fertility / Q000187:drug effects* / Q000502:physiology; D007150:Immunohistochemistry; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012671:Seminiferous Tubules / Q000187:drug effects* / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; C037304:cyhalothrin