title: Association of clinical and magnetic resonance imaging findings with outcome in dogs with presumptive acute noncompressive nucleus pulposus extrusion: 42 cases (2000-2007).
abstract: OBJECTIVE
  To assess associations of severity of neurologic signs (neurologic score), involvement of an intumescence, and findings of magnetic resonance imaging (MRI) with interval to recovery and outcome in dogs with presumptive acute noncompressive nucleus pulposus extrusions.
  
  
  METHODS
  Retrospective case series.
  
  
  METHODS
  42 dogs with presumptive acute noncompressive nucleus pulposus extrusions.
  
  
  METHODS
  Medical records and magnetic resonance (MR) images of dogs evaluated from 2000 through 2007 were reviewed. Inclusion criteria were acute onset of nonprogressive myelopathy following trauma or strenuous exercise, MRI of the spine performed within 7 days after onset, MRI findings consistent with acute noncompressive nucleus pulposus extrusions, and complete medical records and follow-up.
  
  
  RESULTS
  Clinical neuroanatomic localization of lesions was to the C1-C5 (n = 6), C6-T2 (6), T3-L3 (28), and L4-S3 (2) spinal cord segments. Median neurologic score was 3.5. Median duration of follow-up was 804 days (range, 3 to 2,134 days) after onset of neurologic signs. Outcome was successful in 28 (67%) dogs and unsuccessful in 14 (33%) dogs. Severity of neurologic signs, extent of the intramedullary hyperintensity on sagittal and transverse T2-weighted MR images, and detection of intramedullary hypointensity on GRE images were all associated with outcome on univariate analysis. Results of multivariate analysis suggested that maximal cross-sectional area of the intramedullary hyperintensity on transverse T2-weighted MR images was the best predictor of outcome.
  
  
  CONCLUSIONS
  Clinical and MRI findings can help predict outcome in dogs with acute noncompressive nucleus pulposus extrusions.
authors.affiliation: Centre for Small Animal Studies, Animal Health Trust, Newmarket, Suffolk, England.
authors.forename: Luisa
authors.initials: L
authors.lastname: De Risio
authors.forename: Vicki
authors.initials: V
authors.lastname: Adams
authors.forename: Ruth
authors.initials: R
authors.lastname: Dennis
authors.forename: Fraser J
authors.initials: FJ
authors.lastname: McConnell
mesh_terms: D000208:Acute Disease; D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D007405:Intervertebral Disc Displacement / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary*; D008297:Male; D010183:Pancreatic Ducts / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D016896:Treatment Outcome