[Immunomorphology of granulomatous inflammation with Th-1 and Th-2 types of an immune response].
Experimental granulomatosis inflammation induced by BCG-M shown in mice with different type of an immune response has established that with the Tx1 immune type, the granulomatous inflammatory process is more pronounced and disseminated with the high production of tumor necrosis factor-a and interferon-gamma being found. With Th-2 immune response, this process is less pronounced, the cytokine profile being unchanged. The Th-l (cellular) immune response seems to be prevalent in patients with sarcoidosis, high IL-2 level, a preponderance of a granulomatous component, and evident clinical manifestations of the disease. The Th-2 (humoral) immune response appears to be predominant in persons with elevated IL-4 levels, a predominance of fibrosis, and minor clinical manifestations of the disease, Identification of the variants of the course of sarcoidosis on the basis of clinicomorphological and immunological studies is of great importance since this makes it possible to predict the course of the disease and to perform more adequate therapy.
Makarova
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OV
Mikhaĭlova
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LP
D000818:Animals; D000917:Antibody Formation; D001500:BCG Vaccine; D005355:Fibrosis; D006099:Granuloma / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000473:pathology*; D007371:Interferon-gamma / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000276:immunology; D012507:Sarcoidosis / Q000276:immunology / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D001500:BCG Vaccine; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4; D007371:Interferon-gamma