Association of genetic variants in Methylenetetrahydrofolate Reductase and Paraoxonase-1 genes with homocysteine, folate and vitamin B12 in coronary artery disease.
BACKGROUND
The aim of the present study was to investigate the association between genetic variants in metylenetetrahydrofolate reductase (MTHFR) and Paraoxonase-1 (PON1) 55/192 genes and total homocysteine (tHcy), folate, B12 vitamin, and PON1 levels in patients with coronary artery disease (CAD).


METHODS
The study included 235 patients with CAD and 268 healthy control subjects.


RESULTS
LL and LM genotypes and L allele of PON1 55 were over-represented in patients. In contrast, MM genotype and M allele were more frequent in controls. QQ genotype and Q allele of PON1 192 and CT genotype of MTHFR were significantly diminished and QR genotype and R allele were significantly elevated in CAD patients compared with controls. The plasma tHcy were elevated but B12 levels were diminished in patients. PON1 55 and 192 genetic variants were significantly associated with PON1 activity, triglyceride, total cholesterol, tHcy and, high-density lipoprotein-cholesterol and low-density lipoprotein-cholesterol in patients, respectively.


CONCLUSIONS
Genetic variants of PON1 55/192 and MTHFR were associated with CAD.
Aydin
Makbule
M
Department of Neuroscience, The Institute for Experimental Medicine, Istanbul University, Istanbul, Turkey. aydinm@istanbul.edu.tr
Gokkusu
Cahide
C
Ozkok
Elif
E
Tulubas
Feti
F
Unlucerci
Yesim
Y
Pamukcu
Burak
B
Ozbek
Zeynep
Z
Umman
Berrin
B
D000368:Aged; D043303:Aryldialkylphosphatase / Q000235:genetics*; D003324:Coronary Artery Disease / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000378:metabolism*; D006710:Homocysteine / Q000378:metabolism*; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D014805:Vitamin B 12 / Q000378:metabolism*
D006710:Homocysteine; D005492:Folic Acid; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D014805:Vitamin B 12