Central administration of metastin increases food intake through opioid neurons in chicks.
Metastin, an RFamide peptide, has been isolated from human placenta and possesses several physiological actions in mammals. However, little is known about this bioactive peptide in avian species. This study was conducted to assess the effect of metastin on feeding behavior of chicks (Gallus gallus). The food intake of chicks is significantly increased by the intracerebroventricular injection of metastin. Beta-funaltrexamine, a mu-opioid receptor antagonist, significantly attenuates metastin-induced food intake in chicks. In contrast, delta- and kappa-opioid receptor antagonists did not show any influence on metastin-induced food intake in chicks. In addition, administration of N(G)-nitro-L-arginine methyl ester, a nitric oxide synthase inhibitor, did not influence metastin-induced food intake. Taken together, this study shows the orexigenic effect of metastin in chicks and suggests that this effect is mediated by mu-opioid receptor.
Khan
Md Sakirul Islam
MS
Department of Bioresource Production Science, United Graduate School of Agricultural Sciences, Ehime University, Matsuyama 790-8566, Japan.
Ohkubo
Takeshi
T
Masuda
Naoto
N
Tachibana
Tetsuya
T
Ueda
Hiroshi
H
D000818:Animals; D002645:Chickens; D004435:Eating / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007276:Injections, Intraventricular; D059648:Kisspeptins; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009479:Neuropeptides / Q000008:administration & dosage* / Q000494:pharmacology*; D017450:Receptors, Opioid, mu / Q000037:antagonists & inhibitors / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000008:administration & dosage* / Q000494:pharmacology*
C106628:KISS1 protein, human; D059648:Kisspeptins; D009479:Neuropeptides; C416987:RFamide peptide; D017450:Receptors, Opioid, mu; D025521:Tumor Suppressor Proteins; D009271:Naltrexone; C024524:beta-funaltrexamine