title: Mean target intraocular pressure and progression rates in chronic angle-closure glaucoma.
abstract: OBJECTIVE
  The aim of this study was to evaluate risk factors for progression in chronic angle-closure glaucoma (CACG) patients.
  
  
  METHODS
  A retrospective cohort of patient records in East Asia were evaluated for risk factors associated with progressive optic-disc and visual-field loss. There were 101 CACG patients with 5 years of follow-up.
  
  
  RESULTS
  Seventy-one percent (71%) of patients with intraocular pressures (IOP) of >22 mmHg progressed, whereas 26% of patients with IOPs of 13-21 mmHg progressed, and 0% of patients with IOPs of <12 mmHg progressed. The mean IOP was 16.6 +/- 3.4 mmHg in the stable group and 18.8 +/- 3.5 mmHg in the progressed group (P = 0.007). The highest average peak IOP was 23.2 +/- 6.3 mmHg in the stable group and 26.5 +/- 6.5 mmHg in the progressed group (P = 0.03). Generally, patients whose standard deviation of IOP was <2 mmHg (12% progressed) were more often stable, compared to those who were >3 mmHg (33% progressed). A multivariate regression analysis was positive for mean IOP as a clinically important risk factor for progression.
  
  
  CONCLUSIONS
  IOP reduction in CACG patients may help prevent progressive visual-field and optic-disc damage.
authors.affiliation: School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.
authors.forename: Ahmad Tajudin Liza
authors.initials: AT
authors.lastname: Sharmini
authors.forename: Nancy Yuen Shi
authors.initials: NY
authors.lastname: Yin
authors.forename: Shami Shi-Huang
authors.initials: SS
authors.lastname: Lee
authors.forename: Angi L
authors.initials: AL
authors.lastname: Jackson
authors.forename: William C
authors.initials: WC
authors.lastname: Stewart
mesh_terms: D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D009898:Optic Disk / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D014794:Visual Fields