title: Blood lymphocyte proliferation reaction in autoimmune thyropathies.
abstract: Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25- and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25- and CD120-presenting function of blood lymphocytes was revealed. The findings indicate that the course of autoimmune thyroiditis and diffuse toxic goiter is associated with increased levels of basal, mitogen- and cytokine-stimulated proliferation of blood lymphocytes, particularly pronounced in thyroiditis in the euthyrosis stage.
authors.affiliation: Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia.
authors.forename: O I
authors.initials: OI
authors.lastname: Urazova
authors.forename: E B
authors.initials: EB
authors.lastname: Kravets
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nedosekova
authors.forename: A V
authors.initials: AV
authors.lastname: Rogaleva
authors.forename: V N
authors.initials: VN
authors.lastname: Kuznecova
authors.forename: O A
authors.initials: OA
authors.lastname: Rumpel
mesh_terms: D000328:Adult; D006042:Goiter / Q000097:blood*; D006111:Graves Disease / Q000097:blood; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology*; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D013967:Thyroiditis, Autoimmune / Q000097:blood*
chemical_list: D053645:Interleukin-2 Receptor alpha Subunit; D018124:Receptors, Tumor Necrosis Factor