Silver-ion-mediated DNAzyme switch for the ultrasensitive and selective colorimetric detection of aqueous Ag+ and cysteine.
Two states, two applications! An Ag(+)-mediated DNAzyme switch has been designed to detect Ag(+) and cysteine with high sensitivity and selectivity. In the closed state, Ag(+) turns on the switch through the formation of cytosine-Ag(+)-cytosine base pairs, whereas adding cysteine turns off the open switch because it competitively binds to Ag(+). This feature endows the DNAzyme switch with two sensing applications.
Li
Tao
T
State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China.
Shi
Lili
L
Wang
Erkang
E
Dong
Shaojun
S
D002412:Cations; D003124:Colorimetry; D003545:Cysteine / Q000032:analysis*; D021881:DNA, Catalytic / Q000737:chemistry*; D054856:G-Quadruplexes; D006861:Hydrogen Peroxide / Q000737:chemistry; D012834:Silver / Q000032:analysis / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D002412:Cations; D021881:DNA, Catalytic; D012834:Silver; D006861:Hydrogen Peroxide; D003545:Cysteine