title: The study of innate immunity in Japan: a historical perspective.
abstract: Innate immunity is key for host defense in a vast range of organisms, from invertebrates to vertebrates. A number of Japanese scientists have made significant contributions to the clarification of innate immune mechanisms and have applied this knowledge to treatments for various diseases including cancer, allergy and autoimmune disorders. Here, we present an overview of the development of innate immunology by highlighting several Japanese contributors.
authors.affiliation: Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, Japan. tkaisho@rcai.riken.jp
authors.forename: Tsuneyasu
authors.initials: T
authors.lastname: Kaisho
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takeda
mesh_terms: D000818:Animals; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy / Q000266:history; D007564:Japan; D009369:Neoplasms / Q000266:history / Q000276:immunology; D010586:Phagocytes / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000266:history
chemical_list: D051192:Receptors, Pattern Recognition