title: Potential benefit of intraocular pressure reduction in normal-tension glaucoma in South Korea.
abstract: OBJECTIVE
  The aim of this study was to evaluate the potential benefit of intraocular pressure (IOP) reduction in normal tension glaucoma (NTG) Asian adult patients in South Korea.
  
  
  METHODS
  This was a retrospective, multicenter analysis of 166 NTG Asian adult patients in South Korea. The patient population consisted of Korean patients with NTG with at least 5 years of records available for evaluation. Patients all had typical glaucomatous optic-disc and/or visual-field changes but had never had a recorded IOP >21 mmHg.
  
  
  RESULTS
  Overall, 48 (29%) patients were progressed and 116 (71%) were stable over the follow-up period. Of patients with IOPs <or=14 mmHg (21/93), 23% progressed and >or=15 mmHg (27/73) 37% progressed (P = 0.041). The mean IOP for the stable group was 14.0 +/- 1.8 mmHg, whereas with the progressed group the average mean IOP was 14.4 +/- 1.6 mmHg (P = 0.20). The mean peak IOP was 17.4 +/- 2.2 mmHg in the stable group and 17.8 +/- 2.0 mmHg in the progressed group (P = 0.26). Multivariate linear regression analysis did not any identify independent risk factors for progression, including age, gender, or mean and peak IOP.
  
  
  CONCLUSIONS
  This study provides initial evidence that Korean patients with normal-tension glaucoma, treated to lower IOPs, may have a decreased incidence of progression over 5 years than those patients with higher IOPs. More research is required to confirm this finding.
authors.affiliation: Yonsei University, Seoul, Korea.
authors.forename: Gong Je
authors.initials: GJ
authors.lastname: Seong
authors.forename: Sae Heun
authors.initials: SH
authors.lastname: Rho
authors.forename: Chang Sik
authors.initials: CS
authors.lastname: Kim
authors.forename: Jong Il
authors.initials: JI
authors.lastname: Moon
authors.forename: Michael Scott
authors.initials: MS
authors.lastname: Kook
authors.forename: Yong Yeon
authors.initials: YY
authors.lastname: Kim
authors.forename: Kyoung Tak
authors.initials: KT
authors.lastname: Ma
authors.forename: Young Jae
authors.initials: YJ
authors.lastname: Hong
authors.forename: Lindsay A
authors.initials: LA
authors.lastname: Nelson
authors.forename: Bonnie
authors.initials: B
authors.lastname: Kruft
authors.forename: Jeanette A
authors.initials: JA
authors.lastname: Stewart
authors.forename: William C
authors.initials: WC
authors.lastname: Stewart
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D044466:Asian People; D018450:Disease Progression; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007723:Korea / Q000453:epidemiology; D008297:Male; D009898:Optic Disk / Q000473:pathology; D012189:Retrospective Studies; D014794:Visual Fields
chemical_list: D000959:Antihypertensive Agents