Adipokines in the treatment of diabetes mellitus and obesity.
BACKGROUND
The physiology of adipose tissue plays a main role in the pathogenesis of type 2 diabetes mellitus. The secretion of adipocyte-derived hormones, in either an autocrine or a paracrine manner, has been proposed as a relevant mechanism in this process. In this sense, the administration and regulation of hormones derived from adipose tissue arises as an attractive option for treating metabolic disorders.


OBJECTIVE
To review the current understanding of the implication of adipokines in the development of obesity and insulin resistance, as well as their potential use as therapeutic agents.


METHODS
Review of scientific literature.


CONCLUSIONS
This review describes the role of adipokines in generating insulin resistance and the chronic low-grade inflammatory profile accompanying visceral obesity.
Catalán
Victoria
V
Metabolic Research Laboratory, Clínica Universitaria de Navarra, University of Navarra, Pamplona, Spain. vcatalan@unav.es
Gómez-Ambrosi
Javier
J
Rodríguez
Amaia
A
Salvador
Javier
J
Frühbeck
Gema
G
D054392:Adipokines / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000503:physiopathology; D009765:Obesity / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D050151:Subcutaneous Fat / Q000503:physiopathology
D054392:Adipokines