title: Early healing of implants placed into fresh extraction sockets: an experimental study in the beagle dog. De novo bone formation.
abstract: OBJECTIVE
  Describe the early phases of tissue integration in implants placed into fresh extraction sockets and test whether a new implant surface nano-topography (DCD nano-particles, Nanotite) promotes early osseointegration when compared with minimally rough surface implants (DAE, Osseotite).
  
  
  METHODS
  Sixteen beagle dogs received 64 test and control implants randomly installed into the distal socket of (3)P(3) and (4)P(4). Histomorphometric analysis of bone to implant contact (BIC) and bone area was performed at 4 h, 1, 2, 4 and 8 weeks.
  
  
  RESULTS
  Wound healing initiated with a coagulum that was substituted by a provisional matrix at 1 week. Bone formation started concomitant to a marked bone resorption. At 2 weeks, woven bone formation was evident and gradually remodelled into lamellar bone at 4 and 8 weeks. BIC increased similarly throughout the study in both groups with a tendency to higher percentages for the test devices at 2 and 4 weeks. The influence of the DCD nano-particles was more evident at the fourth premolar site.
  
  
  CONCLUSIONS
  Osseointegration occurred similarly at both implant groups, although the socket dimension appeared to influence bone healing. It is suggested that the enhanced nano-topography has a limited effect in the immediate implant surgical protocol.
authors.affiliation: Universidad Complutense de Madrid, Periodoncia, Madrid, Spain. fabiovignoletti@mac.com
authors.forename: Fabio
authors.initials: F
authors.lastname: Vignoletti
authors.forename: Carina
authors.initials: C
authors.lastname: Johansson
authors.forename: Tomas
authors.initials: T
authors.lastname: Albrektsson
authors.forename: Massimo
authors.initials: M
authors.lastname: De Sanctis
authors.forename: Fidel
authors.initials: F
authors.lastname: San Roman
authors.forename: Mariano
authors.initials: M
authors.lastname: Sanz
mesh_terms: D000539:Alveolar Process / Q000033:anatomy & histology* / Q000601:surgery; D000818:Animals; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004285:Dogs; D005260:Female; D053758:Nanoparticles; D016348:Osseointegration / Q000502:physiology*; D013499:Surface Properties; D014081:Tooth Extraction; D020390:Tooth Socket / Q000502:physiology* / Q000601:surgery; D014945:Wound Healing / Q000502:physiology*
chemical_list: D015921:Dental Implants