title: [Breast lesions with moderate and high risk of invasive breast cancer--incidence and some particularities].
abstract: BACKGROUND
  According to the American College of Pathologists consensus statement proliferative lesions with atypia are benign breast conditions with moderately increased breast cancer risk. Ductal carcinoma in-situ and lobular carcinoma in-situ are described as conditions associated with high risk of invasive breast cancer.
  
  
  OBJECTIVE
  Aim of the following investigation was to analyze the incidence of moderate and high risk lesions leading to invasive breast cancer among the central-north Bulgaria women's population and to access by immunohistological method some of their phenotype biological characteristics.
  
  
  METHODS
  Six hundred and twenty one clinical cases, histologically verified as benign breast disorders were reviewed in a retrospective study. In 18 of all revealed cases atypical hyperplasia was found. The remaining 591 patients were with benign breast lesions with non-increased and slightly increased risk of invasive breast cancer. Carcinoma in-situ was obtained in 12 cases for the studied period. CD34 and Ki-67 immunostaining was preformed and evaluated.
  
  
  CONCLUSIONS
  Incidence of benign breast lesions with moderate and high risk was 2.9%, lower than data in literature. Assessment of CD34 positive fibrocytes might play an important role in breast lesion differential diagnosis.
authors.forename: I
authors.initials: I
authors.lastname: Ivanov
authors.forename: G
authors.initials: G
authors.lastname: Baĭchev
authors.forename: T
authors.initials: T
authors.lastname: Betova
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018952:Antigens, CD34 / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D001941:Breast Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D002031:Bulgaria / Q000453:epidemiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012189:Retrospective Studies; D012306:Risk; D055815:Young Adult
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen