title: An efficient and scalable Ritter reaction for the synthesis of tert-butyl amides.
abstract: A scalable procedure for the conversion of nitriles to N-tert-butyl amides via the Ritter reaction was optimized employing tert-butyl acetate and acetic acid. The reaction has a broad scope for aromatic, alkyl, and alpha,beta-unsaturated nitriles.
authors.affiliation: Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA.
authors.forename: Jean C
authors.initials: JC
authors.lastname: Baum
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Milne
authors.forename: Jerry A
authors.initials: JA
authors.lastname: Murry
authors.forename: Oliver R
authors.initials: OR
authors.lastname: Thiel
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D009570:Nitriles