Synthesis, characterization and in vitro antiproliferative activities of new 13-cis-retinoyl ferrocene derivatives.
In order to improve biological behavior of the retinoyl derivatives, monoarylferrocenyl alcohols 9a and 9b were synthesized by an improved Suzuki cross-coupling method and their 13-cis-retinoic acid analogues were prepared in moderate to good yields via the Mitsunobu reaction. Their structures were confirmed by IR, (1)H NMR, (13)CNMR, MS spectra and element analysis and their antiproliferative activities were determined in vitro using human cancer cell lines. The results of bioassay showed that these organometallic analogues exhibited higher antiproliferative activities than parent 13-cis-retinoic acid and other retinoyl derivatives.
Long
Bohua
B
College of Chemistry and Chemical Engineering and Biomedical Engineering Center, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China.
Liang
Shengzong
S
Xin
Dingcheng
D
Yang
Yingbin
Y
Xiang
Jiannan
J
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D015474:Isotretinoin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D012176:Retinoids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
D005296:Ferrous Compounds; D012176:Retinoids; D015474:Isotretinoin