Positive influence of aging on the occurrence of fat replacement in the right ventricular myocardium determined by multislice-CT in subjects with atherosclerosis.
OBJECTIVE
We evaluated predictors of fat replacement (FR) in the right-ventricular-myocardium (RVM) determined by MSCT in atherosclerotics not receiving anti-arrhythmia drugs and evaluated the relationship between the presence of FR in the RVM and the occurrence of ventricular premature beats (VPB).


METHODS
120-consecutive-atherosclerotics (101-males, 11-85 years) not receiving anti-arrhythmia drugs for VPB, who underwent MSCT for evaluating atherosclerosis and Holter-ECG within one-month, were retrospectively analyzed for FR in the RVM and its relationship with age, body mass index (BMI), and occurrence of VPB.


RESULTS
31-subjects had FR in RVM (18-males; median 67 years), and 89 did not (53-males, median 56 years). Median age was significantly higher in subjects with FR in RVM (P<0.01). The median BMI was 23.0 in subjects with FR and 23.0 in those without (not significant). Average number of VPB by Holter-ECG was 1445 in 31 subjects with FR. Without FR, the average number of VPB was 995. The difference in the numbers of VPB was not significant (P=0.73). A logistic-regression-model using age, male sex and BMI indicated that age was associated with an increased incidence of FR in the RVM (relative risk=1.055, 95% CI 1.019-1.092, P<0.05).


CONCLUSIONS
Age but not BMI is significantly associated with the presence of FR in the RVM. Aging might have a positive influence on the occurrence of FR in the RVM as determined by MSCT in atherosclerotics, but FR in the RVM had no influence on the occurrence of VPB.
Hori
Yasuhiko
Y
Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
Funabashi
Nobusada
N
Uehara
Masae
M
Ueda
Marehiko
M
Takaoka
Hiroyuki
H
Nakamura
Koki
K
Murayama
Taichi
T
Komuro
Issei
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology*; D019571:Arrhythmogenic Right Ventricular Dysplasia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology*; D050197:Atherosclerosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D002648:Child; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult