Pharmacokinetics of coenzyme q10.
The pharmacokinetics of coenzyme Q10 powder and solution of solubilized form was studied after their oral administration to rats (10 mg/kg). Plasma concentrations of coenzyme Q10 were measured by HPLC with electrochemical detection over 48 hours. Solubilized coenzyme Q10 exhibited high absorption creating higher plasma concentrations of the drug, as a result of which its bioavailability constituted 264% of that for the powder.
Kalenikova
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EI
Department of Pharmacology, Faculty of Basic Medicine, M. V. Lomonosov Moscow State University. eikaleni@fbm.msu.ru
Gorodetskaya
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EA
Medvedev
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OS
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D008297:Male; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D011208:Powders; D014451:Ubiquinone; C024989:coenzyme Q10