title: [Hemoglobin mass in humans during space flight and its simulation].
abstract: The review is a retrospective of the studies of body liquids and blood formation system in long-duration space missions and physiological modeling with, specifically, the non-invasive carbon monoxide method of hemoglobin mass determination. The method is used to assess protein synthesis in general and mass of circulating blood. In the micro-g environments the humans reduce the amount of intracellular liquid including blood plasma and hydration level in addition to hemoglobin and hematocrit decreases. The number of erythrocytes decreases and abnormal forms appear. These alterations are responsible for the so-called erythrocytopenic syndrome observed in microgravity. The article discusses possible factors and mechanisms of the syndrome and dependence on the level of body hydration. The review tries to generalize and interpret the known results and state of the art of these investigations.
authors.forename: I S
authors.initials: IS
authors.lastname: Balakhovskiĭ
authors.forename: V B
authors.initials: VB
authors.lastname: Noskov
mesh_terms: D004911:Erythrocyte Volume; D004912:Erythrocytes / Q000737:chemistry*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D013026:Space Flight; D018561:Space Simulation
chemical_list: D006454:Hemoglobins