Stereoselective synthesis of 15- and 16-substituted isosteviol derivatives and their cytotoxic activities.
By means of functional interconversions in ring D of the tetracyclic diterpene isosteviol (ent-16-ketobeyeran-19-oic acid 1), various 15- and 16-substituted isosteviol derivatives were stereoselectively prepared. The cytotoxic activities in vitro of these new isosteviol derivatives were investigated, and some of them showed noteworthy activities against B16-F10 melanoma cells.
Wu
Ya
Y
Department of Chemistry, New Drug Research & Development Center, Zhengzhou University, Daxue Road 75#, Zhengzhou 450052, PR China.
Dai
Gui-Fu
GF
Yang
Jing-Hua
JH
Zhang
Yun-Xiao
YX
Zhu
Yu
Y
Tao
Jing-Chao
JC
D000818:Animals; D045744:Cell Line, Tumor; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003198:Computer Simulation; D018360:Crystallography, X-Ray / Q000379:methods; D045786:Diterpenes, Kaurane / Q000138:chemical synthesis* / Q000494:pharmacology*; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008956:Models, Chemical; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D045786:Diterpenes, Kaurane; C515747:isosteviol