Arterial stiffness, carotid artery intima-media thickness and plasma myeloperoxidase level in children with type 1 diabetes.
OBJECTIVE
The present study investigated the functional-structural changes of the arteries along with a new biochemical marker of atherosclerosis, plasma myeloperoxidase level, in children with type 1 diabetes (T1DM).


METHODS
We studied 30 children with T1DM, aged 4.7-18.6 years (mean T1DM duration 5.4+/-3.4 years, mean HbA(1c) 9.8%) and 30 healthy subjects, matched by sex, age and body mass index. Fasting blood samples were obtained for myeloperoxidase (MPO). Ultrasonography and pulse wave analysis were used to measure carotid intima-media thickness (IMT), augmentation index corrected to a heart rate of 75 (AIx@75) and pulse wave velocity (PWV).


RESULTS
Children with diabetes had significantly higher plasma MPO levels (p=0.006), increased AIx@75 (p=0.02), IMT (p=0.005) and IMT standard deviation scores (IMT SDS) (p=0.02), compared to the control group. IMT SDS correlated positively with HbA(1c) (r=0.39, p=0.05). PWV, adjusted for age and mean arterial blood pressure, correlated with diabetes duration (r=0.49, p=0.02).


CONCLUSIONS
Children with T1DM have substantially elevated plasma levels of myeloperoxidase as well as atherosclerosis-related structural and functional changes of the arterial wall.
Heilman
Kaire
K
Department of Paediatrics, University of Tartu, Tartu, Estonia. kaire.heilman@kliinikum.ee
Zilmer
Mihkel
M
Zilmer
Kersti
K
Lintrop
Mare
M
Kampus
Priit
P
Kals
Jaak
J
Tillmann
Vallo
V
D000293:Adolescent; D001794:Blood Pressure; D015992:Body Mass Index; D002339:Carotid Arteries / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology*; D004957:Estonia; D005260:Female; D006339:Heart Rate; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008055:Lipids / Q000097:blood; D008297:Male; D009195:Peroxidase / Q000097:blood*; D011674:Pulse; D012016:Reference Values; D017539:Tunica Intima / Q000503:physiopathology*; D017540:Tunica Media / Q000503:physiopathology*; D014655:Vascular Resistance; D044465:White People
D007004:Hypoglycemic Agents; D007328:Insulin; D008055:Lipids; D009195:Peroxidase