title: A novel Bcl-XL inhibitor Z36 that induces autophagic cell death in Hela cells.
abstract: Inhibition of Bcl2 family proteins Bcl-X(L) and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X(L) inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not apoptosis. This special property distinguishes Z36 from other previously reported Bcl-X(L) and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis, and makes Z36 an attractive molecular tool for studying the cellular regulation of autophagic cell death and apoptosis.
authors.affiliation: Beijing Nuclear Magnetic Resonance Center, College of Chemistry and Molecular Engineering, and College of Life Sciences, Peking University, Beijing, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Lin
authors.forename: Zhibin
authors.initials: Z
authors.lastname: Zheng
authors.forename: Yanjun
authors.initials: Y
authors.lastname: Li
authors.forename: Wenyu
authors.initials: W
authors.lastname: Yu
authors.forename: Wu
authors.initials: W
authors.lastname: Zhong
authors.forename: Songhai
authors.initials: S
authors.lastname: Tian
authors.forename: Fang
authors.initials: F
authors.lastname: Zhao
authors.forename: Xiaobai
authors.initials: X
authors.lastname: Ren
authors.forename: Junhai
authors.initials: J
authors.lastname: Xiao
authors.forename: Nan
authors.initials: N
authors.lastname: Wang
authors.forename: Siyang
authors.initials: S
authors.lastname: Liu
authors.forename: Lili
authors.initials: L
authors.lastname: Wang
authors.forename: Fugeng
authors.initials: F
authors.lastname: Sheng
authors.forename: Yingyu
authors.initials: Y
authors.lastname: Chen
authors.forename: Changwen
authors.initials: C
authors.lastname: Jin
authors.forename: Song
authors.initials: S
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Xia
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000378:metabolism; D000970:Antineoplastic Agents / Q000494:pharmacology; D001343:Autophagy; D004305:Dose-Response Relationship, Drug; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D008968:Molecular Conformation; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D020349:Surface Plasmon Resonance; D051020:bcl-X Protein / Q000037:antagonists & inhibitors* / Q000096:biosynthesis*
chemical_list: C543336:5-fluoro-1-(3'-dimethylamino)propyl-indolin-2-one; D000970:Antineoplastic Agents; D007211:Indoles; D019253:Proto-Oncogene Proteins c-bcl-2; D034741:RNA, Small Interfering; D051020:bcl-X Protein; D049452:Green Fluorescent Proteins; C025946:3-methyladenine; D000225:Adenine