title: Dynamic contrast-enhanced magnetic resonance imaging of abdominal solid organ and major vessel: comparison of enhancement effect between Gd-EOB-DTPA and Gd-DTPA.
abstract: OBJECTIVE
  To evaluate the differences in enhancement of the abdominal solid organ and the major vessel on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) obtained with gadolinium ethoxybenzyldiethylenetriamine pentaacetic acid (Gd-EOB-DTPA: EOB) and gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) in the same patients.
  
  
  METHODS
  A total of 13 healthy volunteers underwent repeat assessments of abdominal MR examinations with DCE-MRI using either Gd-DTPA at a dose of 0.1 mmol/kg body weight or EOB at a dose of 0.025 mmol/kg body weight. DCE images were obtained at precontrast injection and in the arterial phase (AP: 25 seconds), portal phase (PP: 70 seconds), and equilibrium phase (EP: 3 minutes). The signal intensities (SIs) of liver at AP, PP, and EP; the SIs of spleen, renal cortex, renal medulla, pancreas, adrenal gland, aorta at AP; and the SIs of portal vein and inferior vena cava (IVC) at PP were defined using region-of-interest measurements, and were used for calculation of signal intensity ratio (SIR).
  
  
  RESULTS
  The mean SIRs of liver (0.195+/-0.140), spleen (1.35+/-0.353), renal cortex (1.58+/-0.517), renal medulla (0.548+/-0.259), pancreas (0.540+/-0.183), adrenal gland (1.04+/-0.405), and aorta (2.44+/-0.648) at AP as well as the mean SIRs of portal vein (1.85+/-0.477) and IVC (1.16+/-0.187) at PP in the EOB images were significantly lower than those (0.337+/-0.200, 1.99+/-0.443, 2.01+/-0.474, 0.742+/-0.336, 0.771+/-0.227, 1.26+/-0.442, 3.22+/-1.20, 2.73+/-0.429, and 1.68+/-0.366, respectively) in the Gd-DTPA images (P<0.05 each). There was no significant difference in mean SIR of liver at PP between EOB (0.529+/-0.124) and Gd-DTPA (0.564+/-0.139). Conversely, the mean SIR of liver at EP was significantly higher with EOB (0.576+/-0.167) than with Gd-DTPA (0.396+/-0.093) (P<0.001).
  
  
  CONCLUSIONS
  Lower arterial vascular and parenchymal enhancement with Gd-EOB, as compared with Gd-DTPA, may require reassessment of its dose, despite the higher late venous phase liver parenchymal enhancement.
authors.affiliation: Department of Radiology, Kawasaki Medical School, Okayama, Japan. ttamada@med.kawasaki-m.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tamada
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Ito
authors.forename: Teruki
authors.initials: T
authors.lastname: Sone
authors.forename: Akira
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshida
authors.forename: Koki
authors.initials: K
authors.lastname: Kakuba
authors.forename: Daigo
authors.initials: D
authors.lastname: Tanimoto
authors.forename: Hiroki
authors.initials: H
authors.lastname: Higashi
authors.forename: Takenori
authors.initials: T
authors.lastname: Yamashita
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology* / Q000098:blood supply; D000311:Adrenal Glands / Q000033:anatomy & histology; D000328:Adult; D001011:Aorta / Q000033:anatomy & histology; D003287:Contrast Media; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000033:anatomy & histology; D011169:Portal Vein / Q000033:anatomy & histology; D012016:Reference Values; D013154:Spleen / Q000033:anatomy & histology; D014682:Vena Cava, Inferior / Q000033:anatomy & histology
chemical_list: D003287:Contrast Media; C073590:gadolinium ethoxybenzyl DTPA; D019786:Gadolinium DTPA