title: [True hermaphroditism and sequences. Diagnostic implications regarding two cases].
abstract: True hermaphroditism is a disorder of sexual differentiation characterized by the presence of ovarian and testicular tissue in a person and it determines an increased risk for developing gonad cancer. Diagnostic and medical-surgical procedures with opportunity and successful in true hermaphroditism, facilitate the prevention of gonadoblastoma, besides contributing to solving social problem for assignation of sex. In this paper we present two cases with true hermaphroditism that had cytogenetic analysis and search for sequences of chromosome Y. Both patients, had a karyotype 46,XX and showed positive polymorphic regions in chromosome Y. The molecular detection of the Y chromosome is a non-invasive and fast procedure that allows explore cell lines by cytogenetic analysis. We conclude that this procedure is useful as it streamlines the management of disorders of sexual differentiation to identify individuals with higher risk to gonad cancer.
authors.affiliation: Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara.
authors.forename: José de Jesús
authors.initials: Jde J
authors.lastname: Toscano-Flores
authors.forename: Jorge
authors.initials: J
authors.lastname: Padilla-Gutiérrez
authors.forename: Luis
authors.initials: L
authors.lastname: Becerra-Solano
authors.forename: Manuel
authors.initials: M
authors.lastname: Díaz-Rodríguez
authors.forename: Oscar
authors.initials: O
authors.lastname: Bañuelos-Robles
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivas-Solís
authors.forename: María de Lourdes
authors.initials: Mde L
authors.lastname: Ramírez-Dueñas
mesh_terms: D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D050090:Ovotesticular Disorders of Sex Development / Q000175:diagnosis*