title: Impact of obesity on perioperative morbidity and mortality after pancreaticoduodenectomy.
abstract: BACKGROUND
  Obesity has been implicated as a risk factor for perioperative and postoperative complications. The aim of this study was to determine the impact of obesity on morbidity and mortality in patients undergoing pancreaticoduodenectomy (PD).
  
  
  METHODS
  Between January 2000 and July 2007, 262 patients underwent PD at Thomas Jefferson University Hospital, of whom 240 had complete data, including body mass index (BMI; calculated as kg/m(2)) for analysis. Data on BMI, preoperative parameters, operative details, and postoperative course were collected. Patients were categorized as obese (BMI >or= 30), overweight (BMI >or= 25 and < 30), or normal weight (BMI < 25). Complications were graded according to previously published scales. Other end points included length of postoperative hospital stay, blood loss, and operative duration. Analyses were performed using univariate and multivariable models.
  
  
  RESULTS
  There were 103 (42.9%) normal-weight, 71 (29.6%) overweight, and 66 (27.5%) obese patients. There were 5 perioperative deaths (2.1%), with no differences across BMI categories. A significant difference in median operative duration and blood loss between obese and normal-weight patients was identified (439 versus 362.5 minutes, p = 0.0004; 650 versus 500 mL, p = 0.0139). In addition, median length of stay was significantly longer for BMI (9.5 versus 8 days, p = 0.095). Although there were no significant differences in superficial wound infections, obese patients did have an increased rate of serious complications compared with normal-weight patients (24.2% versus 13.6%, respectively; p = 0.10).
  
  
  CONCLUSIONS
  Obese patients undergoing PD have a substantially increased blood loss and longer operative time but do not have a substantially increased length of postoperative hospital stay or rate of serious complications. These findings should be considered when assessing patients for operation and when counseling patients about operative risk, but they do not preclude obese individuals from undergoing definitive pancreatic operations.
authors.affiliation: Department of Surgery, Thomas Jefferson University, Jefferson Pancreas, Biliary and Related Disease Center, Philadelphia, PA 19107, USA.
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Williams
authors.forename: Ernest L
authors.initials: EL
authors.lastname: Rosato
authors.forename: Eugene P
authors.initials: EP
authors.lastname: Kennedy
authors.forename: Karen A
authors.initials: KA
authors.lastname: Chojnacki
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Andrel
authors.forename: Terry
authors.initials: T
authors.lastname: Hyslop
authors.forename: Cataldo
authors.initials: C
authors.lastname: Doria
authors.forename: Patricia K
authors.initials: PK
authors.lastname: Sauter
authors.forename: Jordan
authors.initials: J
authors.lastname: Bloom
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Yeo
authors.forename: Adam C
authors.initials: AC
authors.lastname: Berger
mesh_terms: D000368:Aged; D016063:Blood Loss, Surgical; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D009765:Obesity / Q000150:complications*; D050177:Overweight / Q000150:complications; D016577:Pancreaticoduodenectomy / Q000009:adverse effects* / Q000379:methods / Q000401:mortality*; D010414:Pennsylvania / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology* / Q000401:mortality; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome