title: Heme-oxygenase-2 immunolabelling in pig jejunum.
abstract: Heme-oxygenase-2 generates carbon monoxide in the enteric nervous system and in interstitial cells of Cajal in the canine, mouse and human jejunum. Carbon monoxide is considered a non-adrenergic and non-cholinergic inhibitory neurotransmitter and it establishes and maintains the resting membrane potential in the stomach and small intestine. The aim of this study was to determine the distribution of heme-oxygenase-2 in the enteric nervous system of the pig jejunum. Heme-oxygenase-2 immunoreactivity was found in neurons of myenteric ganglia and in nerve fibers in the circular and longitudinal muscle layers. These results suggest that carbon monoxide is produced in the enteric nervous system of the pig jejunum and might mediate inhibitory neural activity in myenteric ganglia and inhibitory neural input to smooth muscle cells in the circular and longitudinal muscle layers.
authors.affiliation: Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 14049-900 Ribeirão Preto, SP, Brazil. nmmatsuda@uol.com.br
authors.forename: Nilce Mitiko
authors.initials: NM
authors.lastname: Matsuda
authors.forename: Steven M
authors.initials: SM
authors.lastname: Miller
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Szurszewski
mesh_terms: D000818:Animals; D017615:Enteric Nervous System / Q000378:metabolism; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D013552:Swine
chemical_list: D006419:Heme Oxygenase (Decyclizing); C105245:heme oxygenase-2