Association of polymorphisms in interferon regulatory factor 5 gene with rheumatoid arthritis: a metaanalysis.
OBJECTIVE
We investigated potential associations between rheumatoid arthritis (RA) and interferon regulatory factor 5 (IRF5) polymorphisms in a metaanalysis.


METHODS
This metaanalysis included 5 case-control studies, which provided a total of 6582 RA cases and 5375 controls. Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) in IRF5 (rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles.


RESULTS
Among 4 candidate SNP, rs729302, rs2004640, and rs2280714 were statistically significant; both allele C of rs729302 and allele G of rs2004640 within the promoter region of IRF5 were associated with a protective effect [random-effects (RE) OR 0.889, 95% confidence interval (CI) 0.803-0.977, p=0.015 for rs729302; and RE OR 0.905, 95% CI 0.848-0.965, p=0.002 for rs2004640]. Similar results were also obtained in T allele of rs2280714 in the 3'-untranslated region (RE OR 0.927, 95% CI 0.866-0.992, p=0.029). There was no evidence of publication bias from funnel-plot asymmetry and Egger's regression test.


CONCLUSIONS
Our metaanalysis supported the evidence of the significant role of IRF5 polymorphisms in RA.
Han
Seung Woo
SW
The Center of Rheumatology, Department of Internal Medicine, Daegu Fatima Hospital, and Department of Preventive Medicine, Kyungpook National University School of Medicine, 576-13, Sinam 4 dong, Donggu, Daegu, 701-010, Republic of Korea.
Lee
Won Ki
WK
Kwon
Ki Tae
KT
Lee
Byung Ki
BK
Nam
Eon Jeong
EJ
Kim
Gun Woo
GW
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology; D016208:Databases, Factual; D014644:Genetic Variation; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics* / Q000276:immunology; D051379:Mice; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics
C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors