title: Subcorneal pustulosis with combined lack of IgG/IgM and monoclonal gammopathy type IgA/Kappa.
abstract: Subcorneal pustulosis (Sneddon-Wilkinson disease) is a rare inflammatory neutrophilic dermatosis. While subcorneal pustulosis is often associated with an IgA gammopathy, the combined lack of IgG/IgM seen in our case is rare. An 83-year-old man with combined lack of IgG/IgM and monoclonal gammopathy type IgA/Kappa presented with subcorneal pustules. Intravenous immunoglobulin therapy led to complete regression and might be another therapeutic option.
authors.affiliation: Eduard Arning Clinic for Dermatology and Allergy, Asklepios Clinic St. Georg, Hamburg, Germany. raschastrid@hotmail.com
authors.forename: Astrid
authors.initials: A
authors.lastname: Rasch
authors.forename: Melanie
authors.initials: M
authors.lastname: Schimmer
authors.forename: Christian A
authors.initials: CA
authors.lastname: Sander
mesh_terms: D000369:Aged, 80 and over; D006801:Humans; D017099:IgG Deficiency / Q000150:complications* / Q000188:drug therapy*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage; D008297:Male; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors