Cryptococcal meningoradiculitis: an atypical presentation after initiation of antiretroviral therapy.
Atypical presentations of cryptococcal infection have been described as clinical manifestations of immune reconstitution inflammatory syndrome (IRIS) in HIV-infected patients following commence of antiretroviral therapy (ART). The authors describe a patient presenting with cryptococcal meningoradiculitis two weeks after initiation of ART. In patients with advanced HIV disease, immune reconstitution induced by ART can precipitate onset of atypical clinical manifestations in those patients with latent cryptococcal infection of the central nervous system.
Jongwutiwes
Ubonvan
U
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. siujw@mahidol.ac.th
Malathum
Kumthorn
K
Sungkanuparph
Somnuek
S
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000009:adverse effects*; D044966:Anti-Retroviral Agents / Q000009:adverse effects; D002443:Ceftriaxone / Q000627:therapeutic use; D002939:Ciprofloxacin / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000503:physiopathology*; D006801:Humans; D019259:Lamivudine / Q000009:adverse effects; D016919:Meningitis, Cryptococcal / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D019829:Nevirapine / Q000009:adverse effects; D011843:Radiculopathy / Q000139:chemically induced* / Q000175:diagnosis / Q000209:etiology; D018119:Stavudine / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D044966:Anti-Retroviral Agents; D019259:Lamivudine; D002939:Ciprofloxacin; D002443:Ceftriaxone; D000666:Amphotericin B; D019829:Nevirapine; D018119:Stavudine