Polymorphisms of pro-inflammatory genes and prostate cancer risk: a pharmacogenomic approach.
In this paper, we consider the role of the genetics of inflammation in the pathophysiology of prostate cancer (PCa). This paper is not an extensive review of the literature, rather it is an expert opinion based on data from authors' laboratories on age-related diseases and inflammation. The aim is the detection of a risk profile that potentially allows both the early identification of individuals at risk for disease and the possible discovery of potential targets for medication. In fact, a major goal of clinical research is to improve early detection of age-related diseases, cancer included, by developing tools to move diagnosis backward in disease temporal course, i.e., before the clinical manifestation of the malady, where treatment might play a decisive role in preventing or significantly retarding the manifestation of the disease. The better understanding of the function and the regulation of inflammatory pathway in PCa may help to know the mechanisms of its formation and progression, as well as to identify new targets for the refinement of new treatment such as the pharmacogenomics approach.
Caruso
Calogero
C
Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy. marcoc@unipa.it
Balistreri
Carmela Rita
CR
Candore
Giuseppina
G
Carruba
Giuseppe
G
Colonna-Romano
Giuseppina
G
Di Bona
Danilo
D
Forte
Giusi Irma
GI
Lio
Domenico
D
Listì
Florinda
F
Scola
Letizia
L
Vasto
Sonya
S
D000375:Aging / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology; D008297:Male; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000276:immunology*
D018836:Inflammation Mediators