Can progressive and non-progressive behavioural variant frontotemporal dementia be distinguished at presentation?
BACKGROUND
Recent findings suggest that patients with behavioural variant frontotemporal dementia (bv-FTD) differ in their disease progression (progressive vs non-progressive patients). The current study investigates whether the two groups can be discriminated by their clinical features at first presentation.


METHODS
Archival clinical data of the Early Onset Dementia Clinic, Cambridge, UK, were analysed for 71 patients with bv-FTD: 45 progressive and 26 non-progressive cases with more than 3 years of follow-up.


RESULTS
The subgroups were largely indistinguishable on the basis of the presenting clinical features but could be distinguished on general cognitive (Addenbrooke's Cognitive Examination-revised) and selected supportive diagnostic features (distractibility, stereotypic speech, impaired activities of daily living (ADLs) and current depression).


CONCLUSIONS
Progressive and non-progressive patients are difficult to differentiate on the basis of current clinical diagnostic criteria for FTD but a combination of general cognitive, executive dysfunction and impaired ADL measures appear to be the most promising discriminators.
Hornberger
M
M
Prince of Wales Medical Research Institute, University of New South Wales, Sydney, Australia.
Shelley
B P
BP
Kipps
C M
CM
Piguet
O
O
Hodges
J R
JR
D000203:Activities of Daily Living / Q000145:classification / Q000523:psychology; D017668:Age of Onset; D000368:Aged; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D012919:Social Behavior; D012920:Social Behavior Disorders / Q000145:classification / Q000175:diagnosis* / Q000473:pathology