title: roX RNAs: non-coding regulators of the male X chromosome in flies.
abstract: The roX RNAs represent one of the paradigm examples of large non-coding RNAs involved in chromatin regulation. Interestingly, roX genes have a dual life. The RNA product is part of the MSL complex required for dosage compensation of the male X chromosome in Drosophila while the genomic location is used as a binding platform for MSL complex assembly. In this review we discuss both aspects of roX function and propose an integrated model for possible mechanisms how these RNAs might be involved in epigenetic regulation of the male X chromosome.
authors.affiliation: Gene Expression Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ilik
authors.forename: Asifa
authors.initials: A
authors.lastname: Akhtar
mesh_terms: D000818:Animals; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics*; D005804:Genes, Lethal; D006801:Humans; D008297:Male; D008957:Models, Genetic; D022661:RNA, Untranslated / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics*; D014158:Transcription, Genetic; D014960:X Chromosome
chemical_list: D029721:Drosophila Proteins; D022661:RNA, Untranslated; D014157:Transcription Factors; C454144:roX1 protein, Drosophila