[Interface shear stress between the artificial bones and injectable calcium phosphate glue: an experimental study in rabbits].
OBJECTIVE
To evaluate the effect of the composite bone material, fibrin glue (FG) combined with beta-tricalcium phosphate (beta-TCP)/monocalcium phosphate, in repairing bone defects and assess the feasibility of using this cement for artificial joint fixation.


METHODS
Bone defects were induced in 16 normal adult New Zealand white rabbits at the bilateral femoral lateral condyles where an 8-mm-deep hole (4 mm in diameter) was drilled on each side. The composite FG/calcium phosphate cement (CPC) (solution: power volume ratio of 0.3:1) was injected on one side of the bone defects (experimental group) and pressurized for 10 minutes, and CPC was injected on the other side (control). The rabbits were sacrificed at 2, 4, 8 or 12 weeks after the operation for gross observation and biomechanical tests.


RESULTS
The composite material FG/CPC was more effective than CPC for bone defect repair, and biomechanical tests revealed significant differences between them (P<0.05). The shear stress of the artificial bone cement in the FG/CPC group was stronger than that in CPC group.


CONCLUSIONS
The FG/CPC composite possesses good biocompatibility and osteoconductivity and may serve as an ideal material for repairing bone defects.
Zhao
Liang
L
Department of Orthopaedics, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China. Zhaoliang711@yahoo.cn
Li
Qi
Q
Lin
Li-jun
LJ
Zhang
Li
L
Liu
Cheng-long
CL
Ding
Chao
C
D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001696:Biomechanical Phenomena; D018786:Bone Substitutes / Q000737:chemistry*; D002130:Calcium Phosphates / Q000737:chemistry*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000737:chemistry*; D020007:Implants, Experimental; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D033081:Shear Strength; D023822:Tissue Engineering / Q000379:methods
D001672:Biocompatible Materials; D018786:Bone Substitutes; D002130:Calcium Phosphates; D015718:Fibrin Tissue Adhesive; C485817:beta-tricalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous