5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa.
A new alkaloid, 5-bromo-8-methoxy-1-methyl-beta-carboline (1), has been isolated from the New Zealand marine bryozoan Pterocella Vesiculosa. Structural elucidation was achieved through NMR spectroscopic and mass spectrometric analysis, and a single-crystal X-ray diffraction analysis of 1 was performed. The biological activity of 1 was assessed against P388 murine leukemia cells and three microorganisms and compared with that of a number of related beta-carboline alkaloids.
Till
Marisa
M
Department of Chemistry, UniVersity of Waikato, Private Bag, Hamilton, New Zealand.
Prinsep
Michèle R
MR
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002013:Bryozoa / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D009520:New Zealand; D019906:Nuclear Magnetic Resonance, Biomolecular
C540709:5-bromo-8-methoxy-1-methyl-beta-carboline; D000470:Alkaloids; D002243:Carbolines