[Wnt/beta-catenin signal pathway and malignant hematological disease -- review].
Wnt/beta-catenin is the most important and more understanding pathway in Wnt pathways, which is closely related to pathogenesis and development of many solid tumors. Recently, researches discovered that Wnt/beta-catenin signal pathway may be involved in malignant hematopoiesis, and abnormally activated in many hematological-malignancies. This article reviews the newest studies on relationship between Wnt/beta-catenin signal pathway and hematological malignancies (multiple myeloma, chronic myeloid leukemia, chronic lymphocytic leukemia, acute leukemia and so on) in order to reveal the related pathogenesis of hematological malignancies and provide new opinions for target therapy of these diseases.
Wang
Yun-Xiu
YX
Laboratory of Hematology, Shengjing Hospital, China Medical University, Shenyang 110022, China.
Zhang
Ji-Hong
JH
Gu
Zhao-Wei
ZW
D019337:Hematologic Neoplasms / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*; D051176:beta Catenin / Q000378:metabolism*
D051153:Wnt Proteins; D051176:beta Catenin