Is the biology of breast cancer changing? A study of hormone receptor status 1984-1986 and 1996-1997.
Using archived tumours, those from 1984-1986 and 1996-1997 underwent immunohistochemistry for hormone receptors and grade analysis. A significant shift towards more ER-positive and low-grade disease was found; this appears to reflect screening practices, but could still influence survival.
Brown
S B F
SB
Department of Surgery, Crosshouse Hospital, Glasgow Royal Infirmary, Scotland, UK. sylvg82@hotmail.com
Mallon
E A
EA
Edwards
J
J
Campbell
F M
FM
McGlynn
L M
LM
Elsberger
B
B
Cooke
T G
TG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000209:etiology* / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000378:metabolism*; D012923:Social Class; D016019:Survival Analysis; D013997:Time Factors
D011960:Receptors, Estrogen