Radiation recall dermatitis after pre-sensitization with pegylated liposomal doxorubicin.
Radiation recall dermatitis (RRD) is a rare cutaneous reaction occurring within a previously irradiated field, precipitated by certain drugs. We report a case of RRD occurring after pre-sensitization with pegylated liposomal doxorubicin (PLD) in a woman with Stage IV breast cancer. The RRD occurred in one of the patient's four previous radiotherapy fields. We discuss the time/dose factors of radiation exposure and measure the corresponding skin dose. In our case the radiation dose was low and below previously reported thresholds, and illustrates that there is a more complex interaction between the radiotherapy and the trigger agent than has previously been considered.
Gzell
Cecelia E
CE
Department of Radiation Oncology, Royal Prince Alfred Hospital, Sydney, NSW, Australia. cgzell@gmail.com
Carroll
Susan L
SL
Suchowerska
Natalka
N
Beith
Jane
J
Tan
King
K
Scolyer
Richard A
RA
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011092:Polyethylene Glycols / Q000009:adverse effects*; D011829:Radiation Dosage; D011855:Radiodermatitis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D011878:Radiotherapy / Q000009:adverse effects; D012720:Severity of Illness Index; D013848:Thigh; D013997:Time Factors
C506643:liposomal doxorubicin; D011092:Polyethylene Glycols; D004317:Doxorubicin