title: In patient dose reconstruction using a cine acquisition for dynamic arc radiation therapy.
abstract: An amorphous silicon (a-Si) electronic portal imaging device (EPID) was implemented to perform transit in vivo dosimetry for dynamic conformal arc therapy (DCAT). A set of images was acquired for each arc irradiation using the EPID cine acquisition mode, that supplies a frame acquisition rate of one image every 1.66 s, with a monitor unit rate equal to 100 UM/min. In these conditions good signal stability, +/-1% (2SD) evaluated during 3 months, signal reproducibility within +/-0.8% (2SD) and linearity with dose and dose rate within +/-1% (2SD) were obtained. The transit signal, S (t), due to the transmitted radiotherapy beam below a solid phantom, measured by the EPID cine acquisition mode was used to determine, (1) a set of correlation functions, F(w, L), defined as the ratio between S (t) and the dose at half thickness, D (m), measured in solid water phantoms of different thicknesses, w and with square fields of side L, (2) a set of factors, f(d, L), that take into account the different x-ray scatter contribution from the phantom to the S (t) signal as a function of the variation, d, of the air gap between the phantom and the EPID. The reconstruction of the isocenter dose, D (iso), for DCAT was obtained convolving the transit signal values, obtained at different gantry angles, with the respective reconstruction factors determined by a house-made software. The method was applied to a first patient and the results show that the reconstructed D (iso) values can be obtained with an accuracy within +/-5%. In conclusion, it was assessed that an a-Si EPID with the cine acquisition mode is suitable to perform transit in vivo dosimetry for the DCAT therapy.
authors.affiliation: Istituto di Fisica, Università Cattolica del S. Cuore, Largo F. Vito 1, 00168, Rome, Italy. a.piermattei@rm.unicatt.it
authors.forename: Angelo
authors.initials: A
authors.lastname: Piermattei
authors.forename: Andrea
authors.initials: A
authors.lastname: Fidanzio
authors.forename: Luigi
authors.initials: L
authors.lastname: Azario
authors.forename: Francesca
authors.initials: F
authors.lastname: Greco
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mameli
authors.forename: Savino
authors.initials: S
authors.lastname: Cilla
authors.forename: Luca
authors.initials: L
authors.lastname: Grimaldi
authors.forename: Guido
authors.initials: G
authors.lastname: D'Onofrio
authors.forename: Boris Giuseppe
authors.initials: BG
authors.lastname: Augelli
authors.forename: Gerardina
authors.initials: G
authors.lastname: Stimato
authors.forename: Diego
authors.initials: D
authors.lastname: Gaudino
authors.forename: Sara
authors.initials: S
authors.lastname: Ramella
authors.forename: Rolando
authors.initials: R
authors.lastname: D'Angelillo
authors.forename: Francesco
authors.initials: F
authors.lastname: Cellini
authors.forename: Lucio
authors.initials: L
authors.lastname: Trodella
mesh_terms: D000465:Algorithms; D006801:Humans; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D020266:Radiotherapy, Conformal / Q000379:methods*