[The influence of further processing on Psoralea corylifolia alcohol extracts and the content of psoralen and isopsoralen].
OBJECTIVE
To improve the processing method of Psoralea corylifolia.


METHODS
The self-made processing machine was used to flatten Psoralea corylifolia. Then it was extracted with water soluble and alcohol soluble with Psoralea corylifolia unflatten as the amount of Psoralea corylifolia and the content of psoralen and isopsoralen were factors. HPLC was used. The analytical column was a Supelco ODS-C18. The mobile phase consisted of methanol-water (43:57). The detector wavelength was 246 nm. The column temperature was 30 degrees C.


RESULTS
Under the same condition, the conditioning treatment increased the water or ethanol extracting amount of Psoralea corylifolia and the content of psoralen and isopsoralen of the processing samples compared with the unconditioning treatment. The amount of water soluble extracts and erhanol soluble extracts increased 0.61 times and 1.53 times, respectively. And the content of psoralen and isopsoralen in water soluble and erhanol soluble extracts increased 1.22 times.


CONCLUSIONS
The method to flatten Psoralea corylifolia can significantly improve the content of extraction and extraction rate of active components. It can also enhance the clinical effectiveness. The method is reasonable and deserves to be popularized.
Zhu
Guang-Ping
GP
Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing 210029, China.
Shao
Jia-De
JD
Wu
Xu-Tong
XT
Zou
Xiao-Juan
XJ
Shao
Qian
Q
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D000431:Ethanol; D005638:Fruit / Q000737:chemistry; D011564:Furocoumarins / Q000032:analysis* / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D029907:Psoralea / Q000737:chemistry*; D011786:Quality Control; D013678:Technology, Pharmaceutical / Q000379:methods*
D004365:Drugs, Chinese Herbal; D011564:Furocoumarins; D000431:Ethanol