title: [A 55-year-old woman with thymoma and hypogammaglobulinemia (Good syndrome), ulcerative colitis, and cytomegalovirus infection].
abstract: METHODS
  The authors report on a 55-year-old female patient after R1 resection of a malignant thymoma with spindle type epithelial cells (WHO type A, Masaoka stage III) referred for further therapy of an ulcerative colitis. At that time, both adjuvant radiation and cytostatic therapy were not applicable due to severe activity of the ulcerative colitis. Under immunosuppressive treatment with azathioprine and steroids, the patient developed cytomegalovirus (CMV) enteritis which was triggered by therapy-induced leukopenia. After a switch from azathioprine to mycophenolatmofetil (MMF) treatment and administration of cidofovir because of nonresponse to ganciclovir and incompatibility of foscarnet sodium (Foscavir), the patient clinically improved. In addition, the patient was treated with immunoglobulins every 3-4 weeks because of antibody deficiency. At present, 3.5 years after R1 resection, the patient still has no clues of a remaining tumor mass under current immunosuppressive therapy. Ulcerative colitis is also in complete remission stage.
  
  
  CONCLUSIONS
  This case indicates the very rare features of a syndrome with thymoma and antibody deficiency which was first described by Robert Good. Furthermore, the impact of immunosuppressive therapy and management of opportunistic infections on the course of this disease is obvious.
authors.affiliation: Klinik für Gastroenterologie/Hepatologie, Universitätsklinikum Essen, Essen, Germany.
authors.forename: Alisan
authors.initials: A
authors.lastname: Kahraman
authors.forename: Michael
authors.initials: M
authors.lastname: Miller
authors.forename: Evelyn
authors.initials: E
authors.lastname: Maldonado-Lopez
authors.forename: Hideo A
authors.initials: HA
authors.lastname: Baba
authors.forename: Ulrich
authors.initials: U
authors.lastname: Treichel
authors.forename: Guido
authors.initials: G
authors.lastname: Gerken
mesh_terms: D000361:Agammaglobulinemia / Q000175:diagnosis* / Q000188:drug therapy; D000998:Antiviral Agents / Q000627:therapeutic use; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use; D000077404:Cidofovir; D003093:Colitis, Ulcerative / Q000175:diagnosis* / Q000188:drug therapy; D003586:Cytomegalovirus Infections / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D004751:Enteritis / Q000139:chemically induced / Q000175:diagnosis; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007970:Leukopenia / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D009367:Neoplasm Staging; D009894:Opportunistic Infections / Q000139:chemically induced / Q000175:diagnosis* / Q000188:drug therapy; D063065:Organophosphonates / Q000627:therapeutic use; D011183:Postoperative Complications / Q000175:diagnosis* / Q000188:drug therapy; D013577:Syndrome; D013934:Thymectomy; D013945:Thymoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D063065:Organophosphonates; D003596:Cytosine; D009173:Mycophenolic Acid; D000077404:Cidofovir; D001379:Azathioprine