title: A new cytotoxic homoisoflavonoid from Dracaena cambodiana.
abstract: A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (2) and (2R)-7,4'-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC(50) values of 1.4 and 2.9 microg/ml, respectively.
authors.affiliation: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
authors.forename: Jiao
authors.initials: J
authors.lastname: Wu
authors.forename: You-Xing
authors.initials: YX
authors.lastname: Zhao
authors.forename: Ming
authors.initials: M
authors.lastname: Peng
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031409:Dracaena / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007529:Isoflavones; C539687:cambodianol