[Polymorphism of vitamin D receptor and lead poisoning genetic polymorphism in Han, Uygur and Kazak child in China].
OBJECTIVE
To explore the relationship between the polymorphism of vitamin D receptor (VDR) and genetic polymorphism in Han, uygur and Kazak child in China.


METHODS
The VDR genotyping was determined by PCR-RFLP in 469 Han, 443 Uygur and 516 Kazak child from Xinjiang province. The correlation between the polymorphism of VDR and blood lead levels were explored.


RESULTS
The frequencies of the allele BsmIB and BsmIb in Han child were 6% and 94%, and in Uygur were 18% and 82%, in Kazak were 43% and 57% respectively. Statistic correlation between the distribution of VDR-BsmI alleles and the blood lead level was found in Han and Uygur.


CONCLUSIONS
The genetic susceptibility of VDR polymorphism to lead toxicity may exhibit in a lead dose-dependent manner.
Zhao
Jiangxia
J
College of Public Health, Xinjiang Medical University, Urumuqi 830054, China.
Chen
Yan
Y
Liu
Jiwen
J
Tian
Wei
W
D002648:Child; D002681:China / Q000208:ethnology; D004787:Environmental Pollution / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007854:Lead / Q000097:blood; D007855:Lead Poisoning / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D018167:Receptors, Calcitriol / Q000235:genetics*; D012494:Sampling Studies
D018167:Receptors, Calcitriol; D007854:Lead