title: Antibodies to tetanus, diphtheria and pertussis among healthy adults vaccinated according to the French vaccination recommendations.
abstract: In this sero-epidemiological study, we investigated humoral immunity to three vaccine-preventable diseases--tetanus, diphtheria and pertussis--among 331 adults (aged 18-60 years) attending vaccination centres for travellers and who had been vaccinated according to national recommendations in France. Serological results showed that the percentage of subjects with antibodies to diphtheria and tetanus decreases with age. Results also confirmed surveillance data on vaccination in France, with 7.6% of the study population (13.4% of those aged 18-29 years) having recently acquired a pertussis infection. These results confirm the importance of following French recommendations for regular boosters for tetanus and diphtheria among adults. They also indicate the need for better implementation of the current recommendations for pertussis-vaccine boosters in adults.
authors.affiliation: Faculté de médecine, Université Paris Descartes, Paris, France.
authors.forename: Odile
authors.initials: O
authors.lastname: Launay
authors.forename: Christine
authors.initials: C
authors.lastname: Toneatti
authors.forename: Claire
authors.initials: C
authors.lastname: Bernède
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Njamkepo
authors.forename: Karine
authors.initials: K
authors.lastname: Petitprez
authors.forename: Annie
authors.initials: A
authors.lastname: Leblond
authors.forename: Sylvie
authors.initials: S
authors.lastname: Larnaudie
authors.forename: Catherine
authors.initials: C
authors.lastname: Goujon
authors.forename: Marie-Noelle
authors.initials: MN
authors.lastname: Ungeheuer
authors.forename: Faïza
authors.initials: F
authors.lastname: Ajana
authors.forename: Christian
authors.initials: C
authors.lastname: Raccurt
authors.forename: Jean
authors.initials: J
authors.lastname: Beytout
authors.forename: Christian
authors.initials: C
authors.lastname: Chidiac
authors.forename: Damien
authors.initials: D
authors.lastname: Bouhour
authors.forename: Didier
authors.initials: D
authors.lastname: Guillemot
authors.forename: Nicole
authors.initials: N
authors.lastname: Guiso
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000907:Antibodies, Bacterial / Q000097:blood*; D004165:Diphtheria / Q000276:immunology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology*; D005260:Female; D005602:France; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies; D013742:Tetanus / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology / Q000276:immunology; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine