title: Crystal structure of YfeU protein from Haemophilus influenzae: a predicted etherase involved in peptidoglycan recycling.
abstract: The crystal structure of the H. influenzae YfeU protein, was determined at 1.90 A resolution using multi-wavelength anomalous diffraction. YfeU belongs to a very large conserved family of proteins found mainly in bacteria but also in archaea and eukaryota. The protein is a homolog of eukaryotic glucokinase regulator and is predicted to be a sugar phosphate isomerase or aminotransferase. Here we describe the structure of YfeU and discuss the possible function as an etherase possibly involved in peptidoglycan recycling.
authors.affiliation: Midwest Center for Structural Genomics and Structural Biology Center, Biosciences, Argonne National Laboratory, Argonne, IL 60439, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: P
authors.initials: P
authors.lastname: Quartey
authors.forename: R
authors.initials: R
authors.lastname: Ng
authors.forename: T I
authors.initials: TI
authors.lastname: Zarembinski
authors.forename: A
authors.initials: A
authors.lastname: Joachimiak
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry*; D001665:Binding Sites; D018360:Crystallography, X-Ray; D006193:Haemophilus influenzae / Q000201:enzymology* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010457:Peptidoglycan / Q000378:metabolism*; D011487:Protein Conformation; D017510:Protein Folding; D016415:Sequence Alignment
chemical_list: D001426:Bacterial Proteins; D010457:Peptidoglycan