Activity profile in vitro of micafungin against Spanish clinical isolates of common and emerging species of yeasts and molds.
A collection of 2,278 isolates belonging to 86 different fungal species was tested with micafungin and eight other drugs using the EUCAST procedures. Micafungin was active against species of Candida and Aspergillus (even azole-resistant species) as well as Penicillium spp., Scedosporium apiospermum, and Acremonium spp. It was inactive for species of Basidiomycota and Mucorales and for multiresistant species such as those of Fusarium.
Cuenca-Estrella
Manuel
M
Mycology Department, Spanish National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain. mcuenca-estrella@isciii.es
Gomez-Lopez
Alicia
A
Mellado
Emilia
E
Monzon
Araceli
A
Buitrago
Maria J
MJ
Rodriguez-Tudela
Juan L
JL
D000164:Acremonium / Q000187:drug effects; D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D002175:Candida / Q000145:classification / Q000187:drug effects; D025141:Drug Resistance, Fungal; D054714:Echinocandins / Q000494:pharmacology*; D005658:Fungi / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D055666:Lipopeptides / Q000494:pharmacology*; D000077551:Micafungin; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D009181:Mycoses / Q000382:microbiology; D010407:Penicillium / Q000187:drug effects; D021681:Scedosporium / Q000187:drug effects; D013030:Spain
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077551:Micafungin