Effects of visible light-irradiated camphorquinone and 9-fluorenone on murine oral mucosa.
The purpose of this study was to evaluate the histopathological effects of camphorquinone (CQ) and 9-fluorenone (9F) with or without visible light (VL) irradiation on the oral mucous membranes of mice. VL irradiation resulted in a higher degree of tissue damage after CQ or 9F application, particularly the latter. Necrosis and apoptosis were responsible for the tissue damage after application of either agent in the presence of VL irradiation.
Okada
Norihisa
N
Division of Oral Diagnosis, Department of Diagnostic and Therapeutic Sciences, Meikai University School of Dentistry, Keyakidai, Sakado, Saitama 350-0283, Japan. okada@dent.meikai.ac.jp
Muraoka
Eitoku
E
Fujisawa
Seiichiro
S
Machino
Mamoru
M
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004396:Coloring Agents; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D022162:Cytoplasmic Vesicles / Q000187:drug effects / Q000648:ultrastructure; D003764:Dental Materials / Q000528:radiation effects / Q000633:toxicity*; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D004847:Epithelial Cells / Q000187:drug effects; D005449:Fluorenes / Q000528:radiation effects / Q000633:toxicity*; D005456:Fluorescent Dyes; D020287:In Situ Nick-End Labeling; D008027:Light; D008422:Materials Testing; D051379:Mice; D008813:Mice, Inbred ICR; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D009336:Necrosis; D013280:Stomatitis / Q000139:chemically induced / Q000473:pathology; D013729:Terpenes / Q000528:radiation effects / Q000633:toxicity*
D004396:Coloring Agents; D003764:Dental Materials; D005449:Fluorenes; D005456:Fluorescent Dyes; D013729:Terpenes; C048339:camphoroquinone; C028401:9-fluorenone