title: A single intraoperative sub-tenon's capsule injection of triamcinolone and ciprofloxacin in a controlled-release system for cataract surgery.
abstract: OBJECTIVE
  To compare intraoperative injection of triamcinolone and ciprofloxacin in a controlled-release system (DuoCat) with prednisolone and ciprofloxacin eye drops after cataract surgery.
  
  
  METHODS
  In this randomized, double-masked, controlled trial, a total of 135 patients undergoing cataract surgery were randomly allocated to two groups: 67 patients treated after surgery with prednisolone 1% and ciprofloxacin 3% eye drops four times daily (week 1), three times daily (week 2), twice daily (week 3), and once daily (week 4) and 0.3% ciprofloxacin drops four times daily (weeks 1 and 2), and 68 patients treated at the end of surgery with a sub-Tenon's injection of 25 mg triamcinolone and 2 mg ciprofloxacin in biodegradable microspheres. The patients were examined on postoperative days 1, 3, 7, 14, and 28. The main outcome measures were postoperative anterior chamber cell and flare, intraocular pressure (IOP), lack of anti-inflammatory response, and presence of infection.
  
  
  RESULTS
  No significant differences were observed between the groups in anterior chamber cell (P > 0.14) and flare (P > 0.02) at any postoperative visits. The mean (99% confidence interval) differences in IOP between the prednisolone and triamcinolone groups on days 1, 3, 7, 14, and 28 were -0.4 mm Hg (-2.1 to 1.3), 0.0 mm Hg (-1.4 to 1.3), 0.0 mm Hg (-1.1 to 1.1), -0.2 mm Hg (-1.1 to 0.8), and -0.1 mm Hg (-1.1 to 0.9), respectively. No patient had a postoperative infection.
  
  
  CONCLUSIONS
  One injection of DuoCat had a therapeutic response and ocular tolerance that were equivalent to conventional eye drops in controlling inflammation after cataract surgery. (ClinicalTrials.gov number, NCT00431028.).
authors.affiliation: Hospital de Olhos de Araraquara, Araraquara, São Paulo, Brazil.
authors.forename: Fernando
authors.initials: F
authors.lastname: Paganelli
authors.forename: José A
authors.initials: JA
authors.lastname: Cardillo
authors.forename: Luiz A S
authors.initials: LA
authors.lastname: Melo
authors.forename: David R
authors.initials: DR
authors.lastname: Lucena
authors.forename: Arnobio A
authors.initials: AA
authors.lastname: Silva
authors.forename: Anselmo G
authors.initials: AG
authors.lastname: Oliveira
authors.forename: Ana L
authors.initials: AL
authors.lastname: Höfling-Lima
authors.forename: Quan Dong
authors.initials: QD
authors.lastname: Nguyen
authors.forename: Baruch D
authors.initials: BD
authors.lastname: Kuppermann
authors.forename: Rubens
authors.initials: R
authors.lastname: Belfort
mesh_terms: D000368:Aged; D000867:Anterior Chamber / Q000473:pathology; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000009:adverse effects; D003238:Connective Tissue; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D004337:Drug Carriers; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000517:prevention & control; D005260:Female; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D007267:Injections; D007429:Intraocular Pressure; D007430:Intraoperative Care; D019344:Lactic Acid; D019654:Lens Implantation, Intraocular; D008297:Male; D033401:Microscopy, Acoustic; D009887:Ophthalmoscopy; D018918:Phacoemulsification; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011183:Postoperative Complications / Q000517:prevention & control*; D011239:Prednisolone / Q000008:administration & dosage / Q000009:adverse effects; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects; D014606:Uveitis, Anterior / Q000517:prevention & control
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D002939:Ciprofloxacin; D011239:Prednisolone; D014222:Triamcinolone Acetonide