title: Association analysis of serotonin receptor 7 gene (HTR7) and risperidone response in Chinese schizophrenia patients.
abstract: Several lines of evidence suggest that the human 5-HT(7) receptor may be involved in the pharmacodynamics of risperidone and may influence clinical response of the drug. A pharmocogenetics study of this receptor may therefore be useful in developing individualized therapy. But few studies about it have been done. In this study, we genotyped ten single nucleotide polymorphisms (SNPs) distributed throughout the HTR7 gene and analyzed six of them for association with the reduction of Brief Psychiatric Rating Scale (BPRS) scores in drug-naive Chinese schizophrenia patients, following an eight-week period of risperidone monotherapy. The confounding effects of nongenetic factors were estimated and the baseline symptom score as well as the duration of illness were included as covariates for adjustment. No significant correlation of HTR7 with antipsychotic efficacy was detected in either genotype or haplotype analysis. These results demonstrate that variations in the HTR7 gene may not be good genetic markers for predicting the therapeutic efficacy of risperidone.
authors.affiliation: Bio-X Center, Shanghai Jiao Tong University, Shanghai 200030, PR China.
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wei
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Jiekun
authors.initials: J
authors.lastname: Xuan
authors.forename: Ronglin
authors.initials: R
authors.lastname: Che
authors.forename: Jing
authors.initials: J
authors.lastname: Du
authors.forename: Shengying
authors.initials: S
authors.lastname: Qin
authors.forename: Yi
authors.initials: Y
authors.lastname: Xing
authors.forename: Bo
authors.initials: B
authors.lastname: Gu
authors.forename: Lun
authors.initials: L
authors.lastname: Yang
authors.forename: Huafang
authors.initials: H
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Guoyin
authors.initials: G
authors.lastname: Feng
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Xing
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics; D011569:Psychiatric Status Rating Scales; D011985:Receptors, Serotonin / Q000235:genetics*; D018967:Risperidone / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000235:genetics*; D055815:Young Adult
chemical_list: D014150:Antipsychotic Agents; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor; D018967:Risperidone