One- and two-photon turn-on fluorescent probe for cysteine and homocysteine with large emission shift.
A novel dendritic chromophore with efficient intramolecular charge transfer (ICT) and strong two-photon absorption (TPA) was designed as a turn-on fluorescent probe for cysteine (Cys) and homocysteine (Hcy). The probe exhibited greatly enhanced fluorescence intensity as well as a very large emission peak shift (165 nm) upon addition of Cys/Hcy due to ICT switch off. The sensing process was also monitored by two-photon excited fluorescence (TPEF).
Zhang
Xuanjun
X
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
Ren
Xinsheng
X
Xu
Qing-Hua
QH
Loh
Kian Ping
KP
Chen
Zhi-Kuan
ZK
D003545:Cysteine / Q000032:analysis; D005453:Fluorescence; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006710:Homocysteine / Q000032:analysis; D015394:Molecular Structure; D017785:Photons; D011092:Polyethylene Glycols / Q000737:chemistry; D013329:Structure-Activity Relationship
D005456:Fluorescent Dyes; D006710:Homocysteine; D011092:Polyethylene Glycols; D003545:Cysteine