Regulation of angiogenesis by oxygen and metabolism.
Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regarding the emerging crosstalk between angiogenesis and metabolism. We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism.
Fraisl
Peter
P
Vesalius Research Center, Leuven, Belgium.
Mazzone
Massimiliano
M
Schmidt
Thomas
T
Carmeliet
Peter
P
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism; D001808:Blood Vessels / Q000378:metabolism; D019070:Cell Lineage; D042783:Endothelial Cells / Q000378:metabolism; D044127:Epigenesis, Genetic; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D009389:Neovascularization, Pathologic; D010100:Oxygen / Q000378:metabolism*; D015398:Signal Transduction; D000099162:Endothelial PAS Domain-Containing Protein 1
D051792:Basic Helix-Loop-Helix Proteins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D010100:Oxygen; D000099162:Endothelial PAS Domain-Containing Protein 1; C497442:HIF1A protein, human