Developments in the clinical understanding of osteoarthritis.
With the recognition that osteoarthritis is a disease of the whole joint, attention has focused increasingly on features in the joint environment which cause ongoing joint damage and are likely sources of pain. This article reviews current ways of assessing osteoarthritis progression and what factors potentiate it, structural abnormalities that probably produce pain, new understandings of the genetics of osteoarthritis, and evaluations of new and old treatments.
Felson
David T
DT
Boston University School of Medicine, Suite 200, 650 Albany Street, Boston, MA 02118, USA. ncarras@bu.edu
D002986:Clinical Trials as Topic; D018450:Disease Progression; D006801:Humans; D010003:Osteoarthritis / Q000235:genetics* / Q000473:pathology* / Q000628:therapy*; D012307:Risk Factors