title: Pharmacokinetics of coenzyme q10.
abstract: The pharmacokinetics of coenzyme Q10 powder and solution of solubilized form was studied after their oral administration to rats (10 mg/kg). Plasma concentrations of coenzyme Q10 were measured by HPLC with electrochemical detection over 48 hours. Solubilized coenzyme Q10 exhibited high absorption creating higher plasma concentrations of the drug, as a result of which its bioavailability constituted 264% of that for the powder.
authors.affiliation: Department of Pharmacology, Faculty of Basic Medicine, M. V. Lomonosov Moscow State University. eikaleni@fbm.msu.ru
authors.forename: E I
authors.initials: EI
authors.lastname: Kalenikova
authors.forename: E A
authors.initials: EA
authors.lastname: Gorodetskaya
authors.forename: O S
authors.initials: OS
authors.lastname: Medvedev
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D008297:Male; D011208:Powders; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
chemical_list: D011208:Powders; D014451:Ubiquinone; C024989:coenzyme Q10