title: The effect of oral and IV ramosetron on postoperative nausea and vomiting in patients undergoing gynecological laparoscopy with total intravenous anesthesia.
abstract: OBJECTIVE
  Ramosetron can be administered orally as well as intravenously. We investigated the effect of oral ramosetron on postoperative nausea and vomiting (PONV) in patients undergoing gynecological laparoscopy.
  
  
  METHODS
  One hundred and twenty women were allocated randomly to one of three groups (n = 40 in each) to receive saline (control), 0.1 mg oral ramosetron (PO), or 0.3 mg IV ramosetron (IV). Total intravenous anesthesia (TIVA) with propofol and remifentanil was used in all patients.
  
  
  RESULTS
  The incidence of complete response (no PONV, no rescue) in the control, IV, and PO groups was: 65%, 90%, and 87.5%, respectively, during the first 1 h; and 67.5%, 87.5%, and 80%, respectively, during 1 to 24 h.
  
  
  CONCLUSIONS
  The effect of oral ramosetron 0.1 mg was comparable to that of IV ramosetron 0.3 mg on the prevention of PONV in women undergoing gynecological laparoscopy with TIVA. Both the oral and IV forms were effective at preventing PONV during the first 1 h after surgery.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Gil Medical Center, Gachon University of Medicine and Science, 1198 Guwol-dong, Namdong-gu, Incheon, 405-760, Korea.
authors.forename: Dongchul
authors.initials: D
authors.lastname: Lee
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Shin
authors.forename: Chun Hoe
authors.initials: CH
authors.lastname: Ku
authors.forename: Yeon Soo
authors.initials: YS
authors.lastname: Park
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Kwak
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000771:Anesthesia, Intravenous; D000932:Antiemetics / Q000008:administration & dosage / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D013509:Gynecologic Surgical Procedures; D006801:Humans; D006993:Hypnotics and Sedatives; D007275:Injections, Intravenous; D010535:Laparoscopy; D008874:Midazolam; D008875:Middle Aged; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control*; D011292:Premedication; D055815:Young Adult
chemical_list: D000932:Antiemetics; D001562:Benzimidazoles; D006993:Hypnotics and Sedatives; C071315:ramosetron; D008874:Midazolam