[Rectal perforation in a patient treated with combination chemotherapy for lung cancer].
A 74-year old man was treated with first-cycle chemotherapy of paclitaxel (70 mg/m2=110 mg day 1, 8, 15) and carboplatin (AUC5=500 mg day 1) for lung cancer (c-T3N2M0, stage III A). On day 6 abdominal pain appeared, while on day 7 abdominal CT showed a perforation of the digestive tract. Thirty-three hours after the onset he underwent Hartmann operation during which we recognized a perforation 1.7 cm in size in the rectum. Although the cause of the perforation was unknown from the pathological findings, anticancer agents were suspected to be involved. Perforation should be taken into consideration in connection with acute abdominal disease after chemotherapy.
Samejima
Joji
J
Dept. of Surgery, Yokohama Minami-Kyousai Hospital.
Adachi
Hiroyuki
H
Kawamoto
Masakazu
M
Saeki
Hiroyuki
H
Kato
Naoto
N
Fujisawa
Jun
J
Matsukawa
Hiroshi
H
Rino
Yasushi
Y
Masuda
Munetaka
M
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D012002:Rectal Diseases / Q000139:chemically induced / Q000473:pathology* / Q000601:surgery