PLATINUM: a web tool for analysis of hydrophobic/hydrophilic organization of biomolecular complexes.
The PLATINUM (Protein-Ligand ATtractions Investigation NUMerically) web service is designed for analysis and visualization of hydrophobic/hydrophilic properties of biomolecules supplied as 3D-structures. Furthermore, PLATINUM provides a number of tools for quantitative characterization of the hydrophobic/hydrophilic match in biomolecular complexes e.g. in docking poses. These complement standard scoring functions. The calculations are based on the concept of empirical Molecular Hydrophobicity Potential (MHP).


BACKGROUND
The PLATINUM web tool as well as detailed documentation and tutorial are available free of charge for academic users at http://model.nmr.ru/platinum/. PLATINUM requires Java 5 or higher and Adobe Flash Player 9.


BACKGROUND
Supplementary data are available at Bioinformatics online.
Pyrkov
Timothy V
TV
M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya, 16/10, 117997 GSP, Moscow V-437, Russia. pyrkov@nmr.ru
Chugunov
Anton O
AO
Krylov
Nikolay A
NA
Nolde
Dmitry E
DE
Efremov
Roman G
RG
D001665:Binding Sites; D030562:Databases, Protein; D057927:Hydrophobic and Hydrophilic Interactions; D020407:Internet; D008024:Ligands; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D012984:Software
D008024:Ligands; D011506:Proteins