title: Future demographic trends decrease the proportion of ischemic stroke patients receiving thrombolytic therapy: a call to set-up therapeutic studies in the very old.
abstract: OBJECTIVE
  Thrombolytic therapy with tissue plasminogen activator (tPA) is rarely applied to ischemic stroke patients aged 80 years and above. As future demographic trends will increase the proportion of older stroke patients, the overall tPA treatment rate may decrease. The aim of the present analysis was to provide an estimate of the future number of ischemic stroke patients and the fraction thereof receiving tPA.
  
  
  METHODS
  In 2005, n=12 906 hospitalized ischemic stroke patients were included into a large registry covering the Federal State of Hesse, Germany. Age- and gender-specific frequency rates for ischemic stroke and tPA therapy were calculated based on the registry and the respective population data. Population projections until 2050 were derived from the Hessian Bureau of Statistics.
  
  
  RESULTS
  Assuming constant age- and gender-specific stroke incidence rates and treatment strategies, the total number of ischemic stroke patients will rise by approximately 68% until 2050, whereas the proportion of tPA-treated ischemic stroke patients will decrease from 4.5% to 3.8% in the same time frame (relative decrease 16%; chi(2) P<0.001).
  
  
  CONCLUSIONS
  Future demographic changes will reduce tPA treatment rates. Therapeutic studies focusing on very old stroke patients are necessary to counteract this trend.
authors.affiliation: Department of Neurology, Goethe University, Frankfurt am Main, Germany. foerch@em.uni-frankfurt.de
authors.forename: Christian
authors.initials: C
authors.lastname: Foerch
authors.forename: Matthias
authors.initials: M
authors.lastname: Sitzer
authors.forename: Helmuth
authors.initials: H
authors.lastname: Steinmetz
authors.forename: Tobias
authors.initials: T
authors.lastname: Neumann-Haefelin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over / Q000706:statistics & numerical data*; D002545:Brain Ischemia / Q000150:complications* / Q000188:drug therapy*; D005260:Female; D005544:Forecasting; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000627:therapeutic use; D011446:Prospective Studies; D012042:Registries; D012737:Sex Factors; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology*; D015912:Thrombolytic Therapy / Q000706:statistics & numerical data*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator