A new and facile synthesis of quinazoline-2,4(1H,3H)-diones.
A new and facile preparation of quinazoline-2,4(1H,3H)-diones was first reported which was the condensation of aromatic o-aminonitriles with DMF or N,N-diethylformamide in the presence of ZnCl(2) (0.5-10 mol %) at 190-200 degrees C in the sealed reactor.
Li
Jiarong
J
School of Chemical Engineering and Environment, Beijing Institute of Technology, Beijing, PR China 100081. jrli@bit.edu.cn
Chen
Xian
X
Shi
Daxin
D
Ma
Shuling
S
Li
Qing
Q
Zhang
Qi
Q
Tang
Jianhong
J
D002384:Catalysis; D002712:Chlorides / Q000737:chemistry; D004126:Dimethylformamide / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry
D002712:Chlorides; D009570:Nitriles; D011799:Quinazolines; D017967:Zinc Compounds; C105334:N,N-diethylformamide; D004126:Dimethylformamide; C016837:zinc chloride; C539604:6,7-dimethoxyquinazoline-2,4(1H,3H)-dione