title: Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study.
abstract: G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population.
authors.affiliation: Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Ohi
authors.forename: Ryota
authors.initials: R
authors.lastname: Hashimoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Tetsuhiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Takahashi
authors.forename: Naomi
authors.initials: N
authors.lastname: Iike
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Fukumoto
authors.forename: Hironori
authors.initials: H
authors.lastname: Takamura
authors.forename: Masao
authors.initials: M
authors.lastname: Iwase
authors.forename: Kouzin
authors.initials: K
authors.lastname: Kamino
authors.forename: Ryouhei
authors.initials: R
authors.lastname: Ishii
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kazui
authors.forename: Ryuji
authors.initials: R
authors.lastname: Sekiyama
authors.forename: Yuri
authors.initials: Y
authors.lastname: Kitamura
authors.forename: Michiyo
authors.initials: M
authors.lastname: Azechi
authors.forename: Koji
authors.initials: K
authors.lastname: Ikezawa
authors.forename: Ryu
authors.initials: R
authors.lastname: Kurimoto
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Kamagata
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Tanimukai
authors.forename: Shinji
authors.initials: S
authors.lastname: Tagami
authors.forename: Takashi
authors.initials: T
authors.lastname: Morihara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ogasawara
authors.forename: Masayasu
authors.initials: M
authors.lastname: Okochi
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Tokunaga
authors.forename: Shusuke
authors.initials: S
authors.lastname: Numata
authors.forename: Masashi
authors.initials: M
authors.lastname: Ikeda
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohnuma
authors.forename: Shu-Ichi
authors.initials: S
authors.lastname: Ueno
authors.forename: Tomoko
authors.initials: T
authors.lastname: Fukunaga
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Tanaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Kudo
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Ohmori
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
mesh_terms: D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins; D016194:Receptors, N-Methyl-D-Aspartate