title: Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.
abstract: Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 deficiency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.
authors.affiliation: Barshop Institute for Longevity and Aging Studies, San Antonio, TX 78245-3207, USA. ikeno@uthscsa.edu
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ikeno
authors.forename: Gene B
authors.initials: GB
authors.lastname: Hubbard
authors.forename: Shuko
authors.initials: S
authors.lastname: Lee
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Cortez
authors.forename: Christie M
authors.initials: CM
authors.lastname: Lew
authors.forename: Celeste R
authors.initials: CR
authors.lastname: Webb
authors.forename: Darlene E
authors.initials: DE
authors.lastname: Berryman
authors.forename: Edward O
authors.initials: EO
authors.lastname: List
authors.forename: John J
authors.initials: JJ
authors.lastname: Kopchick
authors.forename: Andrzej
authors.initials: A
authors.lastname: Bartke
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D015994:Incidence; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000378:metabolism*; D011986:Receptors, Somatotropin / Q000378:metabolism*
chemical_list: D011986:Receptors, Somatotropin; C519530:insulin-like growth factor-1, mouse; D007334:Insulin-Like Growth Factor I