title: Transapical transcatheter mitral valve-in-valve implantation in a human.
abstract: We describe a human transcatheter transapical mitral valve implant within a mitral bioprosthesis (valve-in-valve). A high-risk, 80-year-old man with symptomatic bioprosthetic mitral stenosis was positioned for anterior minithoracotomy. Left ventricular apical access was obtained. After balloon valvuloplasty, a cuffed, 26-mm Cribier-Edwards transcatheter valve (Edwards Lifesciences LLC, Irvine, CA) was deployed within the mitral xenograft, using rapid ventricular pacing. The transcatheter valve functioned properly postoperatively; however, the patient died of multiple organ dysfunction.
authors.affiliation: Division of Cardiac Surgery, St Paul's Hospital, University of British Columbia, Vancouver, Canada. acheung@providencehealth.bc.ca
authors.forename: Anson
authors.initials: A
authors.lastname: Cheung
authors.forename: John G
authors.initials: JG
authors.lastname: Webb
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Wong
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Masson
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Carere
authors.forename: Samuel V
authors.initials: SV
authors.lastname: Lichtenstein
mesh_terms: D000368:Aged; D001705:Bioprosthesis; D006328:Cardiac Catheterization; D017809:Fatal Outcome; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D008946:Mitral Valve Stenosis / Q000601:surgery*; D011474:Prosthesis Design