title: An efficient synthesis of substituted 2-iminothiazolidin-4-one and thiadiazoloquinazolinone derivatives.
abstract: A convenient synthesis of functionalized 2-iminothiazolidin-4-ones and thiadiazoloquinazolinones has been achieved by the reaction of dialkyl acetylenedicarboxylates (DAAD) with 1-pheny-3-pyridin-2-yl-thiourea (1) and 3-amino-2-mercapto-3H-quinazolin-4-one (8), respectively. The starting materials for these processes were prepared from phenyl isothiocyanate, 2-aminopyridine for (1) and anthranilic acid, carbon disulfide, hydrazine for (8). Treatment of these compounds with DAAD resulted in the formation of an intermediate that readily underwent intramolecular cyclization to afford functionalized five membered heterocyclic rings was formed.
authors.affiliation: Department of Chemistry, Shahid Bahonar University of Kerman, 76169 Kerman, Iran.
authors.forename: Ali
authors.initials: A
authors.lastname: Ahmadi
authors.forename: Kazem
authors.initials: K
authors.lastname: Saidi
authors.forename: Hojattollah
authors.initials: H
authors.lastname: Khabazzadeh
mesh_terms: D000480:Alkynes / Q000737:chemistry; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D013830:Thiadiazoles / Q000737:chemistry; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry
chemical_list: D000480:Alkynes; D052999:Quinazolinones; D013830:Thiadiazoles; D053778:Thiazolidines; C022918:acetylenedicarboxylic acid dimethyl ester; D013890:Thiourea