Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells.
FOXP3(+) regulatory T cells, a unique subset of T cells, are critical for orchestrating an immune response and preventing self-reactivity. With the increasing prevalence and unsatisfactory treatment of autoimmunity, allergic diseases, cancer and chronic infections, much attention has been focused on understanding their mechanisms of action in order to manipulate their function. One goal is to develop drugs or biologics that can enhance or abrogate their functions. Another approach is to utilize Tregs in adoptive cell-based therapy to treat autoimmune diseases or transplant-related complications. This review will focus on their therapeutic potential and mechanisms of action, particularly their interaction with dendritic cells.
Tran
Dat Q
DQ
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. dtran@niaid.nih.gov
Shevach
Ethan M
EM
D000818:Animals; D015551:Autoimmunity / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism; D002450:Cell Communication; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology*; D051858:Forkhead Transcription Factors / Q000276:immunology; D006801:Humans; D016219:Immunotherapy, Adoptive; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000637:transplantation*
D015815:Cell Adhesion Molecules; D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors