Lipid profile in post renal transplant patients treated with cyclosporine in Sudan.
Lipid profile abnormality places kidney graft recipients at an increase risk for cardiovascular diseases.This study was undertaken to determine the impact of cyclosporine A (CsA) on lipid profile of transplant patients in Gezira Hospital for Renal Diseases, Medani, Sudan. We studied 78 renal transplant patients with mean age of 42.1 years and mean transplant duration of 3.8 years. Cyclosporine A (CsA), total cholesterol (Tch), triglyceride (TG), HDL cho-lesterol (HDLch), LDL cholesterol (LDLch), and VLDL cholesterol (VLDLch) were estimated. 62.8% of the patients showed significant lipoprotein abnormalities. Renal allograft recipients showed significantly high levels of TG (p< 0.002), Tch (p< 0.00), LDLch (p< 0.01), and VLDLch (p< 0.05) compared with age and sex matched normal subjects. Increased CsA was reported in females and hypertensive patients. A significant negative correlation was noted between post-transplant duration and VLDLch. The study confirms the existence of dyslipidemia in renal trans-plant patients in our patients.
Suleiman
Bahga
B
Department of Biochemistry, Faculty of Applied Medical Sciences, University of Gezira, Sudan.
El Imam
Mohamed
M
Elsabigh
Mohamed
M
Eltahir
Khalid
K
Eltahir
Ahmed
A
Miskeen
Elhadi
E
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003124:Colorimetry; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D006801:Humans; D007118:Immunoassay; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015994:Incidence; D016030:Kidney Transplantation / Q000502:physiology*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011379:Prognosis; D013397:Sudan / Q000453:epidemiology; D014184:Transplantation, Homologous; D055815:Young Adult
D007166:Immunosuppressive Agents; D008055:Lipids; D016572:Cyclosporine