title: Association of erosive esophagitis with Helicobacter pylori eradication: a role of salivary bicarbonate and glycoprotein secretion.
abstract: In some populations, Helicobacter pylori eradication is associated with development of erosive esophagitis. The aim of this study was to evaluate the contribution of salivary bicarbonate and glycoprotein secretion to the pathogenesis of erosive esophagitis developing after H. pylori eradication. Gastroscopy and saliva collection were performed at recruitment and 12 months after completion of eradication therapy. Eighty-eight patients with duodenal ulcer were recruited to the study. Erosive esophagitis was found in 13 patients (grade A, 8 patients; grade B, 4 patients; grade C, 1 patient). Among the 74 subjects who completed the study, erosive esophagitis was detected in 21 patients (grade A, 15 patients; grade B, 6 patients); they all were successfully eradicated. Bicarbonate and glycoprotein secretion was not found to differ significantly between the subjects with and without erosive esophagitis both before and 1 year after H. pylori eradication. However, it was lower in H. pylori-infected (baseline) than in H. pylori-noninfected erosive esophagitis subjects (1 year after successful eradication) (bicarbonate 2.34 [1.29-3.40)]vs. 3.64 [2.70-4.58]micromol/min and glycoprotein 0.23 [0.15-0.31]vs. 0.35 [0.28-0.43] mg/min, P= 0.04 and P= 0.04, respectively). We conclude that changes in salivary bicarbonate and glycoprotein secretion related to H. pylori eradication do not promote the development of erosive esophagitis in duodenal ulcer patients.
authors.affiliation: Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok, Poland.
authors.forename: D B
authors.initials: DB
authors.lastname: Namiot
authors.forename: Z
authors.initials: Z
authors.lastname: Namiot
authors.forename: A R
authors.initials: AR
authors.lastname: Markowski
authors.forename: K
authors.initials: K
authors.lastname: Leszczyńska
authors.forename: R
authors.initials: R
authors.lastname: Bucki
authors.forename: A
authors.initials: A
authors.lastname: Kemona
authors.forename: M
authors.initials: M
authors.lastname: Gołebiewska
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001639:Bicarbonates / Q000737:chemistry; D001944:Breath Tests; D015331:Cohort Studies; D015897:Comorbidity; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology*; D004945:Esophagoscopy / Q000379:methods; D006023:Glycoproteins / Q000378:metabolism; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D011336:Probability; D011379:Prognosis; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D001639:Bicarbonates; D006023:Glycoproteins