Bioactive metabolites produced by Chaetomium globosum, an endophytic fungus isolated from Ginkgo biloba.
A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei.
Qin
Jian-Chun
JC
College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
Zhang
Ya-Mei
YM
Gao
Jin-Ming
JM
Bai
Ming-Sheng
MS
Yang
Sheng-Xiang
SX
Laatsch
Hartmut
H
Zhang
An-Ling
AL
D000818:Animals; D001156:Artemia; D001681:Biological Assay; D002597:Chaetomium / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004353:Drug Evaluation, Preclinical; D005656:Fungal Proteins / Q000378:metabolism*; D005663:Furans / Q000737:chemistry; D020441:Ginkgo biloba / Q000382:microbiology*; D026121:Indole Alkaloids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D011753:Pyrones / Q000737:chemistry; D012231:Rhizobium / Q000378:metabolism
D005656:Fungal Proteins; D005663:Furans; D026121:Indole Alkaloids; D011753:Pyrones; C539431:chaetomugilin D; C019290:chaetoglobosins