Identification of Paracoccidioides brasiliensis in adrenal glands biopsies of two patients with paracoccidioidomycosis and adrenal insufficiency.
The authors report two cases of adrenal insufficiency secondary to infiltration of the adrenal glands by Paracoccidioides brasiliensis. The first patient had been treated for a chronic multifocal form of paracoccidiodomycosis 11 years ago. The diagnosis of the mycosis was done simultaneous with that of the adrenal insufficiency in the second patient. In both patients the diagnosis was done by direct visualization of fungus in adrenal biopsies. They were treated with hormonal supplements and itraconazol by 12 and six months, without relapses during the follow-up period.
Agudelo
Carlos Andrés
CA
Universidad Pontificia Bolivariana, Medellín, Colombia. carlosagudelo@yahoo.com
Muñoz
Carolina
C
Ramírez
Alex
A
Gutierrez
Jonhairo
J
Velez
Santiago
S
Perez
Juan Camilo
JC
Velez
Alejandro
A
Tobon
Angela María
AM
Restrepo
Angela
A
D000311:Adrenal Glands / Q000382:microbiology*; D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010228:Paracoccidioides / Q000302:isolation & purification*; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D017964:Itraconazole; D005438:Fludrocortisone; D011241:Prednisone