Inhibitors of phosphoinositide-3-kinase: a structure-based approach to understanding potency and selectivity.
Phosphoinositide-3-kinase is a pivotal protein involved in a wide variety of signaling cascades and there has been a great deal of interest in the development of potent and selective inhibitors of this enzyme. In this review, the potency and selectivity of the known inhibitors is presented along with key structural information that helps rationalize the observed trends.
Sundstrom
Teather J
TJ
Department of Pharmaceutical Sciences, University of Connecticut, 69 N Eagleville Rd, U-3092, Storrs, CT 06269, USA.
Anderson
Amy C
AC
Wright
Dennis L
DL
D019870:1-Phosphatidylinositol 4-Kinase / Q000037:antagonists & inhibitors*; D001665:Binding Sites; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D047428:Protein Kinase Inhibitors; D019870:1-Phosphatidylinositol 4-Kinase