title: Transcription-factor-mediated epigenetic control of cell fate and lineage commitment.
abstract: Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.
authors.affiliation: Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655-0002, USA. gary.stein@umassmed.edu
authors.forename: Gary S
authors.initials: GS
authors.lastname: Stein
authors.forename: Sayyed K
authors.initials: SK
authors.lastname: Zaidi
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stein
authors.forename: Jane B
authors.initials: JB
authors.lastname: Lian
authors.forename: Andre J
authors.initials: AJ
authors.lastname: van Wijnen
authors.forename: Martin
authors.initials: M
authors.lastname: Montecino
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Young
authors.forename: Amjad
authors.initials: A
authors.lastname: Javed
authors.forename: Jitesh
authors.initials: J
authors.lastname: Pratap
authors.forename: Je-Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Syed A
authors.initials: SA
authors.lastname: Ali
authors.forename: Sandhya
authors.initials: S
authors.lastname: Pande
authors.forename: Mohammad Q
authors.initials: MQ
authors.lastname: Hassan
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000235:genetics*; D002467:Cell Nucleus / Q000235:genetics; D049109:Cell Proliferation; D044127:Epigenesis, Genetic; D006801:Humans; D008938:Mitosis; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D014157:Transcription Factors