Introducing nanochemoprevention as a novel approach for cancer control: proof of principle with green tea polyphenol epigallocatechin-3-gallate.
Chemoprevention, especially through the use of naturally occurring phytochemicals capable of impeding the process of one or more steps of carcinogenesis process, is a promising approach for cancer management. Despite promising results in preclinical settings, its applicability to humans has met with limited success largely due to inefficient systemic delivery and bioavailability of promising chemopreventive agents. Here, we introduce the concept of nanochemoprevention, which uses nanotechnology for enhancing the outcome of chemoprevention. We encapsulated green tea polyphenol epigallocatechin-3-gallate (EGCG) in polylactic acid-polyethylene glycol nanoparticles and observed that encapsulated EGCG retains its biological effectiveness with over 10-fold dose advantage for exerting its proapoptotic and angiogenesis inhibitory effects, critically important determinants of chemopreventive effects of EGCG in both in vitro and in vivo systems. Thus, this study could serve as a basis for the use of nanoparticle-mediated delivery to enhance bioavailability and limit any unwanted toxicity of chemopreventive agents, such as EGCG.
Siddiqui
Imtiaz A
IA
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA.
Adhami
Vaqar M
VM
Bharali
Dhruba J
DJ
Hafeez
Bilal B
BB
Asim
Mohammad
M
Khwaja
Sabih I
SI
Ahmad
Nihal
N
Cui
Huadong
H
Mousa
Shaker A
SA
Mukhtar
Hasan
H
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D016588:Anticarcinogenic Agents / Q000008:administration & dosage*; D017209:Apoptosis / Q000187:drug effects; D002392:Catechin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002642:Chick Embryo; D004355:Drug Stability; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000008:administration & dosage*; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D023041:Xenograft Model Antitumor Assays
D020533:Angiogenesis Inhibitors; D016588:Anticarcinogenic Agents; D002392:Catechin; C045651:epigallocatechin gallate