Adipocytokines are associated with renal function in patients with normal range glomerular filtration rate and type 2 diabetes.
BACKGROUND
Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate the relationship between adiponectin, leptin and renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2 diabetes.


METHODS
In 52 patients, plasma (P-) and urinary (U-) adiponectin and leptin were determined by radioimmunoassay and ELISA, respectively. Kidney function was assessed with GFR (plasma iohexol clearance) and albuminuria (radioimmunoassay).


RESULTS
The patients were aged 58+/-8 years and had a mean BMI value of 31.2+/-5.2 kg/m(2). Our measurements yielded the following values, expressed as median (25th percentile, 75th percentile): P-adiponectin 11.0 (7.1, 14.5) microg/ml, P-leptin 20.7 (9.6, 35.9)ng/ml, U-adiponectin 0.8 (0.3, 1.2) microg/mg creatinine, and U-leptin 1.0 (0.4, 1.9) microg/mg creatinine. Albuminuria correlated with P-adiponectin (R=-0.31, p=0.03), and GFR correlated with U-leptin (R=-0.32, p=0.04).


CONCLUSIONS
Adiponectin and leptin are associated with parameters of renal function already at the stage of apparently normal kidney function in type 2 diabetes. The exact mechanisms of the adipocyte-vasculature axis still remain to be elucidated.
Barlovic
Drazenka Pongrac
DP
Department of Endocrinology, Diabetes and Metabolic Diseases, University Medical Centre Ljubljana, Zaloska 7, 1000 Ljubljana, Slovenia. drazenka.pongrac@gmail.com
Zaletel
Jelka
J
Prezelj
Janez
J
D017667:Adipocytes / Q000378:metabolism; D052242:Adiponectin / Q000378:metabolism*; D000368:Aged; D000419:Albuminuria / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D052242:Adiponectin; D020738:Leptin