title: Kaempferol, a mutagenic flavonol from Helichrysum simillimum.
abstract: Helichrysum simillimum is native to South Africa. It is used for the treatment of coughs, colds, fever, infections, headache, and menstrual pain. Extracts of this species showed mutagenic effects in the Salmonella/microsome assay. The aim of this study was to isolate and determine the mutagenic constituents of H. simillimum. Bioassay-guided fractionation of 90% aqueous methanol extracts, using Salmonella typhimurium TA98, led to the isolation of the flavonol kaempferol.
authors.affiliation: Research Centre for Plant Growth and Development, School of Biological and Conservation Sciences, University of KwaZulu-Natal Pietermaritzburg, Scottsville, South Africa.
authors.forename: Ee
authors.initials: E
authors.lastname: Elgorashi
authors.forename: Fr
authors.initials: F
authors.lastname: van Heerden
authors.forename: J
authors.initials: J
authors.lastname: van Staden
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002478:Cells, Cultured; D036562:Helichrysum / Q000737:chemistry*; D066298:In Vitro Techniques; D044949:Kaempferols / Q000302:isolation & purification / Q000633:toxicity*; D000432:Methanol; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012997:Solvents
chemical_list: D044949:Kaempferols; D009153:Mutagens; D010936:Plant Extracts; D012997:Solvents; C006552:kaempferol; D000432:Methanol