[Pharmacological and pharmacogenetic study of two immunomodulators: azathioprine and 6-mercaptopurine. Strategies for preventing complications].
Thiopurines are frequently used in gastroenterology for Crohn's disease or hemorrhagic rectocolitis. Their metabolism is regulated by a particular enzyme, thiopurine S-methyltransferase or TPMT. There are three ways to evaluate the effectiveness and the risk of side effects associated with this treatment. TPMT activity measurement or genotyping are recommended to decide for treatment, while metabolites determination is a used as marker of monitoring. Phenotypic approach (TPMT activity measurement or metabolites determination) requires delicate techniques and interindividual variations make the interpretation difficult. Genotyping is easier to interpret but cannot exclude some risk of side effects.
Wolf
A
A
Service de biochimie, toxicologie et pharmacologie cliniques, hôpital d'instruction-des-armées-Begin, 69, avenue de Paris, 94160 Saint-Mandé, France.
Burnat
P
P
Garcia-Hejl
C
C
Ceppa
F
F
D001379:Azathioprine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D005838:Genotype; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D015122:Mercaptopurine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism
D007166:Immunosuppressive Agents; D015122:Mercaptopurine; D008780:Methyltransferases; C022745:thiopurine methyltransferase; D001379:Azathioprine