title: CD8 positive T-cell infiltration in the dentate nucleus of paraneoplastic cerebellar degeneration.
abstract: Recent reports have discussed the presence of cytotoxic T cells in paraneoplastic cerebellar degeneration (PCD). We report an autopsy case of PCD associated with anti-Hu antibody, in which we revealed infiltration of CD8+ T cells in and around the dentate nucleus but not in the cerebellar cortex, in addition to severe Purkinje cell loss. Some infiltrated mononuclear cells expressed cytotoxic cell marker, Granzyme B. Decrease of neurons and reduced presynapses were demonstrated in the dentate nucleus. This is the first report that suggests the possibility of the dentate nucleus being primarily attacked followed by Purkinje cell loss in PCD.
authors.affiliation: Molecular Pathology, Center for Chronic Viral Diseases, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Moe Moe
authors.initials: MM
authors.lastname: Aye
authors.forename: Takefumi
authors.initials: T
authors.lastname: Kasai
authors.forename: Yukie
authors.initials: Y
authors.lastname: Tashiro
authors.forename: Hui Qin
authors.initials: HQ
authors.lastname: Xing
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shirahama
authors.forename: Minoru
authors.initials: M
authors.lastname: Mitsuda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Suetsugu
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Osame
authors.forename: Shuji
authors.initials: S
authors.lastname: Izumo
mesh_terms: D000368:Aged; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology*; D002465:Cell Movement / Q000276:immunology*; D002525:Cerebellar Cortex / Q000737:chemistry / Q000276:immunology / Q000473:pathology; D002529:Cerebellar Nuclei / Q000737:chemistry / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008297:Male; D020362:Paraneoplastic Cerebellar Degeneration / Q000276:immunology* / Q000473:pathology*