Preparation and characterization of antioxidant nanospheres from multiple alpha-lipoic acid-containing compounds.
The purpose of this study was to prepare and characterize antioxidant nanospheres composed of multiple alpha-lipoic acid-containing compounds (mALAs). It was found that the nanospheres were remarkably stable under physiologic conditions, maintained the antioxidant property of alpha-lipoic acid, and could be destabilized oxidatively and enzymatically. The preparations were simple and highly reproducible providing a new strategy for the development of nanometer-sized antioxidant biomaterials. The nanospheres may find applications as antioxidant therapeutics and oxidation-responsive antioxidant nanocontainers in drug delivery for pathological conditions characterized by oxidative stress including cancer and neurodegenerative diseases.
Lee
Bong Seop
BS
Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W. Third Street, Suite 800 East, Los Angeles, CA 90048, USA.
Yuan
Xiangpeng
X
Xu
Qijin
Q
McLafferty
Fred S
FS
Petersen
Brian A
BA
Collette
Jeremy C
JC
Black
Keith L
KL
Yu
John S
JS
D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002621:Chemistry / Q000379:methods; D015195:Drug Design; D008956:Models, Chemical; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry; D013696:Temperature; D008063:Thioctic Acid / Q000737:chemistry*; D013997:Time Factors
D000975:Antioxidants; D001672:Biocompatible Materials; D008063:Thioctic Acid; D010100:Oxygen