title: Oxidative stress is increased in serum from Mexican patients with relapsing-remitting multiple sclerosis.
abstract: OBJECTIVE
  To determine the oxidative stress markers in serum from patients with relapsing-remitting multiple sclerosis.
  
  
  METHODS
  Blood samples from healthy controls and 22 patients 15 women (7 aged from 20 to 30 and 8 were > 40 years old) and 7 men (5 aged from 20 to 30 and 2 were > 40 years old) fulfilling the McDonald Criteria and classified as having Relapsing-Remitting Multiple Sclerosis accordingly with Lublin were collected for oxidative stress markers quantification.
  
  
  RESULTS
  Nitric oxide metabolites (nitrates/nitrites), lipid peroxidation products (malondialdehyde plus 4-hidroxialkenals), and glutathione peroxidase activity were significantly increased in serum of subjects with relapsing-remitting multiple sclerosis in comparison with that of healthy controls. These data support the hypothesis that multiple sclerosis is a component closely linked to oxidative stress.
authors.affiliation: Centro de Investigación Biomédica de Occidente, Instituto Mexicano del Seguro Social, Guadalajara, Jalisco, México. genarogabriel@yahoo.com
authors.forename: Genaro Gabriel
authors.initials: GG
authors.lastname: Ortiz
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Macías-Islas
authors.forename: Fermín P
authors.initials: FP
authors.lastname: Pacheco-Moisés
authors.forename: José A
authors.initials: JA
authors.lastname: Cruz-Ramos
authors.forename: Silvia
authors.initials: S
authors.lastname: Sustersik
authors.forename: Elías Alejandro
authors.initials: EA
authors.lastname: Barba
authors.forename: Adriana
authors.initials: A
authors.lastname: Aguayo
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008800:Mexico; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood*; D009566:Nitrates / Q000097:blood; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress; D055815:Young Adult
chemical_list: D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D008315:Malondialdehyde; D005979:Glutathione Peroxidase