[Research on preparation of Shandantong sustained-release tablets].
OBJECTIVE
To optimize the preparation of Shandantong sustained-release tablets.


METHODS
We used the orthogonal experiment to optimize the preparation and determined the contents of Shanzha total flavonoids and tanshinone. Involved technology and hydrophilicity skeleton materials were adopted to prepare the sustained-release tablets.


RESULTS
The best extracted progress of Shanzha total flavonoids and tanshinone were A2B2C1 and A3B1C2, respectively. The hydrophilicity skeleton materials were gel HPMC and acrylic resin.


CONCLUSIONS
The concentration of alcohol and percolated speed are significant factors on the extracted efficacy by analysis of variance. The preparation and prescription of this sustained-release tablet is reasonable.
Yuan
Wen-Peng
WP
Shenzhen Renmin Hospital/The Second Clinical Medical College of Jinan University, Shenzhen 518020, China. yuanwp@yahoo.com.cn
Liu
Lin-Na
LN
Wang
Min
M
D000180:Acrylic Resins / Q000737:chemistry; D027825:Crataegus / Q000737:chemistry; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D015203:Reproducibility of Results; D027561:Salvia miltiorrhiza / Q000737:chemistry; D012995:Solubility; D013607:Tablets; D013678:Technology, Pharmaceutical / Q000379:methods*; D047392:beta-Cyclodextrins / Q000737:chemistry
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D013607:Tablets; D047392:beta-Cyclodextrins; D008747:Methylcellulose; D007785:Lactose