title: Deep brain stimulation of the right nucleus accumbens in a patient with Tourette syndrome. Case report.
abstract: We describe the effects of unilateral right-sided nucleus accumbens (NA) stimulation in a patient with intractable Gilles de la Tourette syndrome (GTS) with associated compulsions and self-injurious behaviour. Pharmacological and behavioural therapies had completely failed to control the patient's tics and compulsions. The electrode (Model 3389 Medtronic, Minneapolis, MN) was implanted in the right NA. At 28-month follow-up, deep brain stimulation (DBS) of the right NA effectively alleviated tics and compulsions with patient's self-injurious behaviour. We suggest that this approach can be an effective treatment option for GTS with intractable motor and vocal tics with associated compulsions with self-injurious behaviour.
authors.affiliation: Department of Neurosurgery, Postgraduate Medical Centre, Warsaw, Poland.
authors.forename: Mirosław
authors.initials: M
authors.lastname: Zabek
authors.forename: Michał
authors.initials: M
authors.lastname: Sobstyl
authors.forename: Henryk
authors.initials: H
authors.lastname: Koziara
authors.forename: Sebastian
authors.initials: S
authors.lastname: Dzierzecki
mesh_terms: D000328:Adult; D000344:Afferent Pathways; D046690:Deep Brain Stimulation / Q000379:methods*; D006801:Humans; D008297:Male; D009714:Nucleus Accumbens; D020323:Tics / Q000517:prevention & control; D005879:Tourette Syndrome / Q000628:therapy*; D016896:Treatment Outcome