Biogenesis of peroxisomes and mitochondria: linked by division.
Peroxisomes and mitochondria are metabolically linked organelles, which are crucial to human health and development. The search for components involved in their dynamics and maintenance led to the interesting finding that mitochondria and peroxisomes share components of their division machinery. Recently, it became clear that this is a common strategy used by mammals, fungi and plants. Furthermore, a closer interrelationship between peroxisomes and mitochondria has been proposed, which might have an impact on functionality and disease conditions. Here, we briefly highlight the major findings, views and open questions concerning peroxisomal formation, division, and interrelationship with mitochondria.
Delille
Hannah K
HK
Centre for Cell Biology, Department of Biology, University of Aveiro, 3810-193 Aveiro, Portugal.
Alves
Renato
R
Schrader
Michael
M
D034281:Dynamins / Q000378:metabolism; D005656:Fungal Proteins / Q000378:metabolism; D007425:Intracellular Membranes / Q000502:physiology*; D008561:Membrane Fusion / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D024101:Mitochondrial Proteins / Q000378:metabolism; D020675:Peroxisomes / Q000502:physiology*; D010940:Plant Proteins / Q000378:metabolism
D005656:Fungal Proteins; D024101:Mitochondrial Proteins; D010940:Plant Proteins; D034281:Dynamins