title: Mechanical and in vitro performance of apatite-wollastonite glass ceramic reinforced hydroxyapatite composite fabricated by 3D-printing.
abstract: In situ hydroxyapatite/apatite-wollastonite glass ceramic composite was fabricated by a three dimensional printing (3DP) technique and characterized. It was found that the as-fabricated mean green strength of the composite was 1.27 MPa which was sufficient for general handling. After varying sintering temperatures (1050-1300 degrees C) and times (1-10 h), it was found that sintering at 1300 degrees C for 3 h gave the greatest flexural modulus and strength, 34.10 GPa and 76.82 MPa respectively. This was associated with a decrease in porosity and increase in densification ability of the composite resulting from liquid phase sintering. Bioactivity tested by soaking in simulated body fluid (SBF) and In Vitro toxicity studies showed that 3DP hydroxyapatite/A-W glass ceramic composite was non-toxic and bioactive. A new calcium phosphate layer was observed on the surface of the composite after soaking in SBF for only 1 day while osteoblast cells were able to attach and attain normal morphology on the surface of the composite.
authors.affiliation: National Metal and Materials Technology Center, National Science and Technology Development Agency, Ministry of Science and Technology, Klong, Klongluang, Pathumthani, Thailand. jintamai@mtec.or.th
authors.forename: J
authors.initials: J
authors.lastname: Suwanprateeb
authors.forename: R
authors.initials: R
authors.lastname: Sanngam
authors.forename: W
authors.initials: W
authors.lastname: Suvannapruk
authors.forename: T
authors.initials: T
authors.lastname: Panyathanmaporn
mesh_terms: D001031:Apatites / Q000737:chemistry*; D001672:Biocompatible Materials; D001826:Body Fluids; D017610:Calcium Compounds / Q000737:chemistry*; D002448:Cell Adhesion; D002478:Cells, Cultured; D002516:Ceramics / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D055119:Elastic Modulus; D005898:Glass / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure; D010316:Particle Size; D016062:Porosity; D011208:Powders; D017640:Silicates / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature; D013997:Time Factors; D014961:X-Ray Diffraction
chemical_list: D001031:Apatites; D001672:Biocompatible Materials; D017610:Calcium Compounds; D011208:Powders; D017640:Silicates; D017886:Durapatite; C031293:calcium silicate