title: Predictors of urinary albumin excretion in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To evaluate urinary albumin excretion (UAE) in normotensive and nondiabetic women with polycystic ovary syndrome (PCOS) in relation to their clinical, endocrine, and metabolic profiles.
  
  
  METHODS
  Observational study.
  
  
  METHODS
  University fertility center.
  
  
  METHODS
  Sixty-three women with PCOS were evaluated.
  
  
  METHODS
  Clinical assessments and urine and blood testing.
  
  
  METHODS
  Urinary albumin excretion, systolic and diastolic blood pressure, serum levels of LH, FSH, PRL, T, 17-hydroxyprogesterone, glucose, insulin, lipids, C-reactive protein, and 24-hour urinary free cortisol.
  
  
  RESULTS
  In univariate and multivariate correlation analysis, UAE correlated with diastolic blood pressure, insulin area under the curve during glucose tolerance test, PRL, and 17-hydroxyprogesterone. Overt microalbuminuria was detected in a significant proportion of subjects.
  
  
  CONCLUSIONS
  Urinary albumin excretion in women with PCOS correlates well with other cardiovascular risk factors. Because the relationship between UAE and adverse cardiovascular events is continuous, evaluation of UAE in the presence of PCOS may provide clinically relevant information and may aid in selecting appropriate patients for more aggressive treatment of likely aggravating factors, such as hyperinsulinemia or borderline hypertension.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of California, Davis, California, USA. ajduleba@ucdavis.edu
authors.forename: Antoni J
authors.initials: AJ
authors.lastname: Duleba
authors.forename: Ibrahim M
authors.initials: IM
authors.lastname: Ahmed
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000378:metabolism; D000419:Albuminuria / Q000150:complications / Q000175:diagnosis* / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism / Q000503:physiopathology / Q000652:urine*; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000418:Albumins; D001786:Blood Glucose; D007328:Insulin; D019326:17-alpha-Hydroxyprogesterone; D002097:C-Reactive Protein