title: The Yin and Yang of the MMS21-SMC5/6 SUMO ligase complex in homologous recombination.
abstract: Maintaining genomic stability is critical for the prevention of disease. Numerous DNA repair pathways help to maintain genomic stability by correcting potentially lethal or disease-causing lesions to our genomes. Mounting evidence suggests that the post-translational modification sumoylation plays an important regulatory role in several aspects of DNA repair. The E3 SUMO ligase MMS21/NSE2 has gained increasing attention for its function in homologous recombination (HR), an error-free DNA repair pathway that mediates repair of double-strand breaks (DSBs) using the sister chromatid as a repair template. MMS21/NSE2 is part of the SMC5/6 complex, which has been shown to facilitate DSB repair, collapsed replication fork restart, and telomere elongation by HR. Here, I review the function of the SMC5/6 complex and its associated MMS21/NSE2 SUMO ligase activity in homologous recombination.
authors.affiliation: Department of Biochemistry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9038, United States. Ryan.Potts@UTSouthwestern.edu
authors.forename: Patrick Ryan
authors.initials: PR
authors.lastname: Potts
mesh_terms: D018797:Cell Cycle Proteins / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone; D004247:DNA / Q000378:metabolism; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D042822:Genomic Instability; D006801:Humans; D008025:Ligases / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011995:Recombination, Genetic; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D016615:Telomere / Q000378:metabolism; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; C432931:SMC5 protein, human; C432932:SMC6 protein, human; D025841:Small Ubiquitin-Related Modifier Proteins; D004247:DNA; D043743:Ubiquitin-Protein Ligase Complexes; D008025:Ligases; C503501:NSMCE2 protein, human