title: Effect of sildenafil on wound healing: an experimental study.
abstract: OBJECTIVE
  We aimed to investigate the effect of sildenafil on the healing process of abdominal wall wound in rats.
  
  
  METHODS
  The study was performed with adult female Wistar-Albino rats. Control group (n = 50) were fed on standard laboratory diet until 12 h before surgery. Study group (n = 50) were applied orally with orogastric tube 10 mg/kg once a day for 10 days of sildenafil therapy. Each rat was anesthetized, and a 4-cm-long midline laparotomy was performed. Ten animals from each group were killed at postoperative days (PODs) 4, 7, 14, 21, and 35. Breaking strength analysis was measured, and the abdominal incision wounds were examined histologically.
  
  
  RESULTS
  Breaking strength for the midline incision, acute inflammation score on POD 14, and neovascularization on PODs 7, 14, 21, and 35 were significantly higher in the study group.
  
  
  CONCLUSIONS
  Sildenafil can be used as a supporting factor in wound healing.
authors.affiliation: hayrullahderici@yahoo.com
authors.forename: Hayrullah
authors.initials: H
authors.lastname: Derici
authors.forename: Erdinç
authors.initials: E
authors.lastname: Kamer
authors.forename: Haluk Recai
authors.initials: HR
authors.lastname: Unalp
authors.forename: Gulden
authors.initials: G
authors.lastname: Diniz
authors.forename: Ali Dogan
authors.initials: AD
authors.lastname: Bozdag
authors.forename: Tugrul
authors.initials: T
authors.lastname: Tansug
authors.forename: Ragip
authors.initials: R
authors.lastname: Ortac
authors.forename: Yesim
authors.initials: Y
authors.lastname: Erbil
mesh_terms: D034861:Abdominal Wall / Q000601:surgery*; D000818:Animals; D005260:Female; D006909:Hydroxyproline / Q000032:analysis; D007813:Laparotomy; D023421:Models, Animal; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011687:Purines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology*; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D006909:Hydroxyproline