title: Cardiac surgery in the parturient.
abstract: Heart disease is the primary cause of nonobstetric mortality in pregnancy, occurring in 1%-3% of pregnancies and accounting for 10%-15% of maternal deaths. Congenital heart disease has become more prevalent in women of childbearing age, representing an increasing percentage (up to 75%) of heart disease in pregnancy. Untreated maternal heart disease also places the fetus at risk. Independent predictors of neonatal complications include a maternal New York Heart Association heart failure classification >2, anticoagulation use during pregnancy, smoking, multiple gestation, and left heart obstruction. Because cardiac surgical morbidity and mortality in the parturient is higher than nonpregnant patients, most parturients with cardiac disease are first managed medically, with cardiac surgery being reserved when medical management fails. Risk factors for maternal mortality during cardiac surgery include the use of vasoactive drugs, age, type of surgery, reoperation, and maternal functional class. Risk factors for fetal mortality include maternal age >35 yr, functional class, reoperation, emergency surgery, type of myocardial protection, and anoxic time. Nonetheless, acceptable maternal and fetal perioperative mortality rates may be achieved through such measures as early preoperative detection of maternal cardiovascular decompensation, use of fetal monitoring, delivery of a viable fetus before the operation and scheduling surgery on an elective basis during the second trimester. Additionally, fetal morbidity may be reduced during cardiopulmonary bypass by optimizing maternal oxygen-carrying capacity and uterine blood flow. Current maternal bypass recommendations include: 1) maintaining the pump flow rate >2.5 L x min(-1) x m(-2) and perfusion pressure >70 mm Hg; 2) maintaining the hematocrit > 28%; 3) using normothermic perfusion when feasible; 4) using pulsatile flow; and 5) using alpha-stat pH management.
authors.affiliation: Baylor College of Medicine Division of Cardiovascular Anesthesiology at the TX Heart Institute, St. Luke's Episcopal Hospital, 6720 Bertner Ave., Houston, TX 77030, USA.
authors.forename: Shobana
authors.initials: S
authors.lastname: Chandrasekhar
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Cook
authors.forename: Charles D
authors.initials: CD
authors.lastname: Collard
mesh_terms: D000328:Adult; D000777:Anesthetics / Q000493:pharmacokinetics / Q000494:pharmacology; D006348:Cardiac Surgical Procedures; D002585:Cesarean Section; D005260:Female; D006331:Heart Diseases / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D016343:Monitoring, Intraoperative; D009125:Muscle Relaxants, Central / Q000493:pharmacokinetics / Q000494:pharmacology; D011247:Pregnancy / Q000502:physiology*; D011249:Pregnancy Complications, Cardiovascular / Q000601:surgery*
chemical_list: D000777:Anesthetics; D009125:Muscle Relaxants, Central