Propofol: a review of its non-anaesthetic effects.
Propofol, a short-acting intravenous anaesthetic agent has gained wide acceptance since its introduction in the late 80s, not only in operating rooms but also in other departments, due to its several advantages. Apart from its multiple anaesthetic advantages, it has been reported recently that propofol exerts a number of non-anaesthetic effects. The drug stimulates constitutive nitric oxide (NO) production and inhibits inducible NO production. Propofol has also anxiolytic properties, which may be related to several neuromediator systems. Moreover, it has antioxidant, immunomodulatory, analgesic, antiemetic and neuroprotective effects. Furthermore, propofol inhibits both platelet aggregation and intracellular calcium increases in response to thrombin or ADP and it also exerts direct inhibitory effects on recombinant cardiac sarcolemmal KATP channels. All these beneficial properties may expand propofol's clinical use.
Vasileiou
Ioanna
I
Department of Experimental Surgery and Surgical Research, Athens, Greece.
Xanthos
Theodoros
T
Koudouna
Eleni
E
Perrea
Despoina
D
Klonaris
Chris
C
Katsargyris
Athanasios
A
Papadimitriou
Lila
L
D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D000932:Antiemetics / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D015742:Propofol / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D000932:Antiemetics; D006993:Hypnotics and Sedatives; D018696:Neuroprotective Agents; D009569:Nitric Oxide; D015742:Propofol