Efficient traceless solid-phase synthesis of 3,4-dihydropyrazino[1,2-b]indazoles and their 6-oxides.
A highly efficient novel traceless solid-phase synthesis of 3,4-dihydropyrazino[1,2-b]indazoles and their 6-oxides was developed by using commercially available building blocks, diamines, 2-nitrobenzenesulfonyl chlorides, and bromoketones/bromoacetates. Mild reaction conditions, diversely substituted building blocks, and high purity of crude products enabled effective combinatorial syntheses of libraries.
Pudelová
Nadezda
N
Department of Chemistry and Biochemistry, 251 Nieuwland Science Center, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Krchnák
Viktor
V
D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D003959:Diamines / Q000138:chemical synthesis / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis / Q000737:chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D009578:Nitrobenzenes / Q000138:chemical synthesis / Q000737:chemistry; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D011719:Pyrazines / Q000138:chemical synthesis / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000191:economics
C542057:3,4-dihydropyrazino(1,2-b)indazole; D003959:Diamines; D006842:Hydrocarbons, Brominated; D007191:Indazoles; D009578:Nitrobenzenes; D010087:Oxides; D011719:Pyrazines; D054852:Small Molecule Libraries; C002732:2-nitrobenzenesulfenyl chloride