Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients.
OBJECTIVE
The goal of this study was to analyse a possible association of admission blood glucose with hospital mortality of polytraumatised patients and to develop an outcome prediction model for this patient group.


METHODS
The outcome of adult polytraumatised patients admitted to the University Hospital of Berne, Switzerland, between 2002 and 2004 with an ISS > or = 17, and more than one severely injured organ system was retrospectively analysed.


RESULTS
The inclusion criteria were met by 555 patients, of which 108 (19.5%) died. Hyperglycaemia proved to be an independent predictor for hospital mortality (P < 0.0001), following multiple regression analysis. After inclusion of admission blood glucose, the calculated mortality prediction model performed better than currently described models (P < 0.0001, AUC 0.924).


CONCLUSIONS
In this retrospective, single-centre study in polytraumatised patients, admission blood glucose proved to be an independent predictor of hospital mortality following regression analysis controlling for age, gender, injury severity and other laboratory parameters. A reliable admission blood glucose-based mortality prediction model for polytraumatised patients could be established. This observation may be helpful in improving the precision of future outcome prediction models for polytraumatised patients. These observations warrant further prospective evaluation.
Kreutziger
Janett
J
Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria. janett.kreutziger@uki.at
Wenzel
Volker
V
Kurz
Andrea
A
Constantinescu
Mihai Adrian
MA
D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D016001:Confidence Intervals; D004636:Emergency Service, Hospital; D005260:Female; D005544:Forecasting; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000401:mortality* / Q000503:physiopathology; D016017:Odds Ratio; D010343:Patient Admission; D012189:Retrospective Studies; D016019:Survival Analysis; D013557:Switzerland / Q000453:epidemiology; D015599:Trauma Severity Indices
D001786:Blood Glucose