[Invasive pulmonary aspergillosis. Occurrence in a non-neutropenic female patient with abdominal sepsis].
Invasive pulmonary aspergillosis (IPA) is a life-threatening infection predominantly affecting immunocompromised patients, e.g. with acute leukemia. This case report demonstrates that IPA can also occur in non-neutropenic critically ill surgical patients. The case of a 63-year-old woman is reported, who developed IPA of the respiratory tract in the course of diffuse purulent peritonitis. First-line therapy with voriconazol failed to be effective. However, application of caspofungin, intensive kinetic therapy (including prone position) and airway management by interventional bronchoscopy enabled successful treatment of this severe complication.
Knüttgen
D
D
Klinik für Anästhesiologie und Operative Intensivmedizin,, Krankenhaus Merheim, Kliniken der Stadt Köln gGmbH, Lehrstuhl für Anästhesiologie II der Privaten Universität Witten/Herdecke, Köln. knuettgend@kliniken-koeln.de
Kamp
M
M
Ströhlein
M
M
Matten
J
J
Chemaissani
A
A
Ernestus
K
K
Sakka
S G
SG
Wappler
F
F
D000005:Abdomen; D000935:Antifungal Agents / Q000627:therapeutic use; D000077336:Caspofungin; D003110:Colonic Neoplasms / Q000150:complications / Q000601:surgery; D016638:Critical Illness; D054714:Echinocandins / Q000627:therapeutic use; D005260:Female; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy* / Q000209:etiology / Q000382:microbiology; D007813:Laparotomy; D055666:Lipopeptides; D008875:Middle Aged; D010538:Peritonitis / Q000150:complications; D026741:Physical Therapy Modalities; D011183:Postoperative Complications / Q000188:drug therapy* / Q000382:microbiology; D011743:Pyrimidines / Q000627:therapeutic use; D018805:Sepsis / Q000150:complications* / Q000382:microbiology; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D000077336:Caspofungin; D065819:Voriconazole