title: Role of fibrin glue in the prevention of cervical leakage and strictures after esophageal reconstruction of caustic injury.
abstract: BACKGROUND
  The colon is the organ most commonly used for esophageal reconstruction after severe caustic injury. Complications of cervical anastomosis are very common. Fibrin sealant may reduce the incidence of complications in this high-risk anastomosis. The purpose of the present study was to assess the role of fibrin glue in the prevention of leakage and stricture at cervical coloesophageal anastomoses in children treated with esophageal reconstruction after caustic injury.
  
  
  METHODS
  This was a case-control study of children with caustic esophageal injury treated surgically with esophageal reconstruction over a 10-year period. In the study group 3-4 ml of fibrin glue was placed over the anastomosis. The following variables were assessed: age, sex, weight, leakage or stricture at the cervical anastomosis, morbidity, and mortality.
  
  
  RESULTS
  The study group included 14 children, and the control group included 24 children. There were no differences in the distributions of sex, age, anthropometric variables, or preoperative laboratory test results. All children underwent esophageal replacement with colon substitution through the retrosternal space. Dehiscence and leakage at the cervical anastomosis were observed in 50% of children in the control group and 28.5% of children in the study group (P = 0.17). Strictures were observed in 7.15% of the study group and 20.8% of the control group, and 5 and 17 children, respectively, developed cervical complications (P = 0.03). There were no differences in major complications, and mortality was similar in the two groups (P = 0.60).
  
  
  CONCLUSIONS
  Fibrin glue, when used as a sealant for cervical coloesophageal anastomosis, can reduce the risk of leakage and stricture.
authors.affiliation: Department of Pediatric Surgery of the Pediatric Hospital, National Western Medical Center, Mexican Institute of Social Security, Guadalajara, Jalisco, Mexico.
authors.forename: Julián Alberto
authors.initials: JA
authors.lastname: Saldaña-Cortés
authors.forename: Francisco
authors.initials: F
authors.lastname: Larios-Arceo
authors.forename: Emilio
authors.initials: E
authors.lastname: Prieto-Díaz-Chávez
authors.forename: Eliseo Portilla
authors.initials: EP
authors.lastname: De Buen
authors.forename: Salvador
authors.initials: S
authors.lastname: González-Mercado
authors.forename: Andrea Socorro
authors.initials: AS
authors.lastname: Alvarez-Villaseñor
authors.forename: Manuel Rodrigo
authors.initials: MR
authors.lastname: Prieto-Aldape
authors.forename: Clotilde
authors.initials: C
authors.lastname: Fuentes-Orozco
authors.forename: Alejandro
authors.initials: A
authors.lastname: González-Ojeda
mesh_terms: D002057:Burns, Chemical / Q000601:surgery; D016022:Case-Control Studies; D002675:Child, Preschool; D002908:Chronic Disease; D004940:Esophageal Stenosis / Q000209:etiology / Q000517:prevention & control*; D004944:Esophagoplasty / Q000009:adverse effects / Q000379:methods*; D004947:Esophagus / Q000293:injuries / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013529:Surgical Wound Dehiscence / Q000209:etiology / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives