title: [The role of Toll-like receptors in regulation of immune responses in norm and pathology].
abstract: We have analyzed the recent data about Toll-like receptors (TLRs) that play the most important role in host immune defense. TLRs involved in induction and modulation of innate and acquired immunity as the integrators of their reactions. Genetic disorders of TLRs or their signaling pathways components were noticed with different pathologies. TLRs are the ideal molecular target for the therapy of many diseases including inflammatory, autoimmune, allergic and tumor diseases.
authors.forename: N Ia
authors.initials: NIa
authors.lastname: Spivak
authors.forename: I M
authors.initials: IM
authors.lastname: Bogdanova
authors.forename: N I
authors.initials: NI
authors.lastname: Martirosova
authors.forename: V V
authors.initials: VV
authors.lastname: Malaĭtsev
mesh_terms: D000818:Animals; D004194:Disease / Q000209:etiology; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D008024:Ligands; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D008024:Ligands; D051193:Toll-Like Receptors