title: Antitumor properties of Gymnosperma glutinosum leaf extracts.
abstract: The present study was undertaken to validate the antitumor potential of Gymnosperma glutinosum from regional people's account, using the in vitro and in vivo L5178Y-R lymphoma murine model. Non-polar G. glutinosum crude extracts were tested on L5178Y-R cells. We found significant (p < 0.05) cytotoxic activity (up to 40%) of the hexane extract, which was further fractioned; fraction 1 (F1) was then observed to produce up to 51% apoptosis-mediated L5178Y-R cytotoxicity in vitro at concentrations lower than 0.98 microg/ml, and possess significant in vivo antitumor activity. This study may support further evaluation of active F1 in clinical trials.
authors.affiliation: Department of Microbiology and Immunology, Biological Sciences College, Autonomous University of Nuevo Leon, N.L., Mexico. rgomez60@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Gomez-Flores
authors.forename: L
authors.initials: L
authors.lastname: Verástegui-Rodríguez
authors.forename: R
authors.initials: R
authors.lastname: Quintanilla-Licea
authors.forename: P
authors.initials: P
authors.lastname: Tamez-Guerra
authors.forename: E
authors.initials: E
authors.lastname: Monreal-Cuevas
authors.forename: R
authors.initials: R
authors.lastname: Tamez-Guerra
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez-Padilla
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D019659:Asteraceae; D045744:Cell Line, Tumor; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts