Association between Helicobacter pylori infection and Posner-Schlossman syndrome.
OBJECTIVE
To investigate possible association between Helicobacter pylori infection and Posner-Schlossman syndrome.


METHODS
In a prospective study, 40 subjects with Posner-Schlossman syndrome were examined. As a control group, 73 subjects without Posner-Schlossman syndrome were selected for comparison with the study group. All participants underwent serologic analysis for the presence of H. pylori infection by an enzyme-linked immunosorbent assay. Positive rate of serum anti-H. pylori IgG was compared between Posner-Schlossman syndrome patients and control participants.


RESULTS
The rate of positive titre (>15 U/ml) of H. pylori was 80.0% in the Posner-Schlossman syndrome group and 56.2% in control group, showing significant difference (Fischer's exact, P=0.014). Multivariate analysis adjusted for various systemic factors revealed that positive titre of anti-H. pylori IgG was a significant risk factor for Posner-Schlossman syndrome with an odds ratio, (4.84, 95.0% CI: 1.10-21.24, P=0.037).


CONCLUSIONS
H. pylori infection occurred significantly more often in Posner-Schlossman syndrome patients. This study suggests that exposure to H. pylori infection is associated with Posner-Schlossman syndrome in Korea.
Choi
C Y
CY
Department of Ophthalmology, Sungkyunkwan University School of Medicine, Kangbuk Samsung Hospital, Seoul, Korea.
Kim
M S
MS
Kim
J M
JM
Park
S H
SH
Park
K H
KH
Hong
C
C
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology / Q000276:immunology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015863:Iridocyclitis / Q000276:immunology / Q000382:microbiology*; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009798:Ocular Hypertension / Q000382:microbiology*; D011446:Prospective Studies; D012307:Risk Factors; D013577:Syndrome
D007074:Immunoglobulin G