Prolonged intrahepatic cholestasis and renal failure secondary to anabolic androgenic steroid-enriched dietary supplements.
The illegal enrichment of anabolic androgenic steroids in over-the-counter dietary supplements is well documented, but the health consequences have not been widely recognized. Three recent reports document cholestatic jaundice and nephropathy due to these compounds. We present 3 additional cases of anabolic androgenic steroid-enriched dietary supplement-induced hepatotoxicity and 1 case of renal failure, and we review the literature and the relevant features of this growing health concern. Recognition of this entity could obviate the need for invasive diagnostic testing and hospitalization and facilitate diagnosis and appropriate counseling.
Krishnan
Prashant V
PV
Division of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI, 48202, USA.
Feng
Zhen-Zhou
ZZ
Gordon
Stuart C
SC
D000328:Adult; D045930:Anabolic Agents / Q000009:adverse effects*; D000728:Androgens / Q000009:adverse effects; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D019587:Dietary Supplements / Q000009:adverse effects*; D006801:Humans; D008297:Male; D051437:Renal Insufficiency / Q000139:chemically induced*; D055815:Young Adult
D045930:Anabolic Agents; D000728:Androgens