title: Wound infiltration with magnesium sulphate and ropivacaine mixture reduces postoperative tramadol requirements after radical prostatectomy.
abstract: OBJECTIVE
  This prospective, randomized, double-dummy study was undertaken to compare the effects of magnesium sulphate (MgSO(4)) administered by the intravenous vs. the infiltration route on postoperative pain and analgesic requirements.
  
  
  METHODS
  Forty ASA I or II men scheduled for radical retropubic prostatectomy under general anaesthesia were randomized into two groups (n=20 each). Two medication sets A and B were prepared at the pharmacy. Each set contained a minibag of 50 ml solution for IV infusion and a syringe of 45 ml for wound infiltration. Group MgSO(4).IV patients received set A with 50 mg/kg MgSO(4) in the minibag and 190 mg of ropivacaine in the syringe. Group MgSO(4)/L received set B with isotonic saline in the minibag and 190 mg of ropivacaine +750 mg of MgSO(4) in the syringe. The IV infusion was performed over 30 min at induction of anaesthesia and the surgical wound infiltration was performed during closure. Pain was assessed every 4 h, using a 100-point visual analogue scale (VAS). Postoperative analgesia was standardized using IV paracetamol (1 g/6 h) and tramadol was administered via a patient-controlled analgesia system. The follow-up period was 24 h.
  
  
  RESULTS
  The total cumulative tramadol consumption was 221 +/- 64.1 mg in group MgSO4.IV and 134 +/- 74.9 mg in group MgSO(4).L (P<0.01). VAS pain scores were equivalent in the two groups throughout the study. No side-effects, due to systemic or local MgSO(4) administration, were observed.
  
  
  CONCLUSIONS
  Co-administration of MgSO(4) with ropivacaine for postoperative infiltration analgesia after radical retropubic prostatectomy produces a significant reduction in tramadol requirements.
authors.affiliation: DAR III, Hôpital Pellegrin-Tripode Bordeaux, Place Amélie Raba-Léon, Bordeaux Cedex, France. patrick.tauzin-fin@chu-bordeaux.fr
authors.forename: P
authors.initials: P
authors.lastname: Tauzin-Fin
authors.forename: M
authors.initials: M
authors.lastname: Sesay
authors.forename: L
authors.initials: L
authors.lastname: Svartz
authors.forename: M-C
authors.initials: MC
authors.lastname: Krol-Houdek
authors.forename: P
authors.initials: P
authors.lastname: Maurette
mesh_terms: D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000008:administration & dosage*; D004311:Double-Blind Method; D006801:Humans; D008278:Magnesium Sulfate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D011468:Prostatectomy; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D000077212:Ropivacaine; D014147:Tramadol / Q000627:therapeutic use*
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D016194:Receptors, N-Methyl-D-Aspartate; D014147:Tramadol; D008278:Magnesium Sulfate; D000077212:Ropivacaine