An efficient and scalable Ritter reaction for the synthesis of tert-butyl amides.
A scalable procedure for the conversion of nitriles to N-tert-butyl amides via the Ritter reaction was optimized employing tert-butyl acetate and acetic acid. The reaction has a broad scope for aromatic, alkyl, and alpha,beta-unsaturated nitriles.
Baum
Jean C
JC
Chemical Process R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, USA.
Milne
Jacqueline E
JE
Murry
Jerry A
JA
Thiel
Oliver R
OR
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry; D013237:Stereoisomerism
D000577:Amides; D009570:Nitriles