title: Neuropsychological profile in early-onset schizophrenia-spectrum disorders: measured with the MATRICS battery.
abstract: OBJECTIVE
  Neurocognitive impairments have been documented in adolescents with early-onset schizophrenia (EOS). There is still inconsistency regarding an average profile, which could be due to the fact that each study uses different tests. The purpose of this study was to examine whether the "Measurement and Treatment Research to Improve Cognition in Schizophrenia" (MATRICS) battery is useful in detecting differences between the patient group and the healthy controls, and to describe the neuropsychological pattern in the EOS group.
  
  
  METHODS
  Neuropsychological functioning was examined in 31 adolescents with schizophrenia spectrum disorders and 67 healthy controls, using the MATRICS battery.
  
  
  RESULTS
  There were significant differences between the patients and the controls on every domain except for social cognition. Patients showed a generalized neurocognitive deficit of 0.8-1.8 SDs compared with controls, with verbal learning, working memory, and visual learning being the most affected areas.
  
  
  CONCLUSIONS
  The MATRICS battery is sensitive in detecting differences between patients and controls in the adolescent population. However, we question the use of Mayer-Salovey-Caruso Emotional Intelligence Test in this age group. Results document a significant generalized deficit in adolescents with EOS.
authors.affiliation: Department of Psychology, University of Oslo, Norway. aina.holmen@psykologi.uio.no
authors.forename: Aina
authors.initials: A
authors.lastname: Holmén
authors.forename: Monica
authors.initials: M
authors.lastname: Juuhl-Langseth
authors.forename: Rune
authors.initials: R
authors.lastname: Thormodsen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.forename: Bjørn Rishovd
authors.initials: BR
authors.lastname: Rund
mesh_terms: D000293:Adolescent; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000706:statistics & numerical data*; D009664:Norway; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011594:Psychometrics / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000175:diagnosis* / Q000523:psychology*; D012016:Reference Values; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology