Formulation and evaluation of in situ gelling system of dimenhydrinate for nasal administration.
Nasal drug delivery has a variety of advantages. Drugs can be rapidly absorbed through the nasal mucosa, giving rapid onset of action, and avoiding presystemic metabolism. In present study; the nasal mucoadhesive in situ gels of anti-emetic drug Dimenhydrinate were formulated using Gellan gum and Carbopol 934P. The in situ gels so prepared were characterized for gelation, viscosity, gel strength, mucoadhesion, drug content, drug diffusion, ex vivo permeation and histopathological studies. The optimized formulation passing from above tests was further subjected to accelerated stability study. It retained the good stability over the period of 90 days. From the overall performance this in situ gel seems to be an effective delivery system for the nasal route.
Belgamwar
Veena S
VS
Department of Pharmaceutics, R C Patel Institute of Pharmaceutical Education and Research, Shirpur, India. dhiraj.chauk@gmail.com
Chauk
Dheeraj S
DS
Mahajan
Hitendra S
HS
Jain
Snehal A
SA
Gattani
Surendra G
SG
Surana
Sanjay J
SJ
D000281:Administration, Intranasal; D000818:Animals; D004111:Dimenhydrinate / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D016503:Drug Delivery Systems; D005782:Gels / Q000737:chemistry*; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D009296:Nasal Cavity / Q000378:metabolism / Q000473:pathology; D012756:Sheep; D014783:Viscosity
D005782:Gels; D006634:Histamine H1 Antagonists; D004111:Dimenhydrinate