title: Down syndrome: a cardiovascular perspective.
abstract: This review focuses on the heart and vascular system in patients with Down syndrome. A clear knowledge on the wide spectrum of various abnormalities associated with this syndrome is essential for skillful management of cardiac problems in patients with Down syndrome. Epidemiology of congenital heart defects, cardiovascular aspects and thyroid-related cardiac impairment in patients with Down syndrome will be discussed.
authors.affiliation: Department of Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: J C
authors.initials: JC
authors.lastname: Vis
authors.forename: M G J
authors.initials: MG
authors.lastname: Duffels
authors.forename: M M
authors.initials: MM
authors.lastname: Winter
authors.forename: M E
authors.initials: ME
authors.lastname: Weijerman
authors.forename: J M
authors.initials: JM
authors.lastname: Cobben
authors.forename: S A
authors.initials: SA
authors.lastname: Huisman
authors.forename: B J M
authors.initials: BJ
authors.lastname: Mulder
mesh_terms: D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D003324:Coronary Artery Disease / Q000453:epidemiology*; D004314:Down Syndrome / Q000453:epidemiology* / Q000235:genetics; D004374:Ductus Arteriosus, Patent / Q000453:epidemiology*; D006330:Heart Defects, Congenital / Q000453:epidemiology*; D006344:Heart Septal Defects, Atrial / Q000453:epidemiology*; D006801:Humans; D008017:Life Expectancy; D015995:Prevalence