[Influence of Qingxiang San on substance P, somatostatin in rats model with the spleen and stomach wet heat syndrome].
OBJECTIVE
To observe the influence of Qingxiang San (QS) on substance P (SP), somatostatin (SS) in rats model of spleen and stomach wet heat syndrome.


METHODS
24 rats were divided into 3 groups (each group 8 rats) randomly: the normal control group (NCG), wet heat group (WHG), QS group (QSG). We set up the spleen and stomach wet heat syndrome of rats model by the composite factors such as greasy and sweet food, wet and hot environment, pathogen and so on. Then the contents of SP, SS were detected by radioimmuno assay.


RESULTS
The content of SP, SS in WHG were obviously lower than NCG (P<0.01); QSG compared with WHG, the content of SP, SS increased (P<0.01); The content of SP obviously increased when QSG compared with NCG (P<0.01); About the content of SS, there was no significant difference between QSG and NCG (P>0.05), illustrating that QS can increase the content of SP, SS which had decreased.


CONCLUSIONS
QS can regulate the content of SP and SS and increase them which had decreased.
Tan
Yong-Zhen
YZ
College of TCM, Southern Medical University, Guangzhou 510515, China.
Wen
Xiao-Min
XM
Chen
Pei-Chan
PC
Li
Yu-Jing
YJ
Chen
Pei-Hong
PH
Huang
Gui-Qiong
GQ
D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011706:Pyloric Antrum / Q000187:drug effects / Q000378:metabolism; D011863:Radioimmunoassay; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000378:metabolism*; D013158:Splenic Diseases / Q000188:drug therapy / Q000378:metabolism*; D013272:Stomach Diseases / Q000188:drug therapy / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D016710:Yin Deficiency / Q000188:drug therapy / Q000378:metabolism
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005768:Gastrointestinal Hormones; D013373:Substance P; D013004:Somatostatin