title: A retrospective analysis of radiation therapy for the treatment of feline vaccine-associated sarcoma.
abstract: We retrospectively evaluated predictive prognostic factors in 73 cats with vaccine-associated sarcoma given postsurgical curative (n = 46, most with clean margins) or coarse fractionated radiotherapy (n = 27, most with either macroscopic disease or dirty margins). The former animals displayed a median survival of 43 months and a median progression free interval (PFI) of 37 months, the latter reached a median survival of 24 months and a median PFI of 10 months. In cats undergoing coarse fractionated therapy, factors predictive of a better outcome included lack of visible mass (n = 10) as opposed to macroscopic disease (n = 17, survival: 30 versus 7 months, P = 0.025; PFI: 20 versus 4 months, P = 0.01), adjuvant chemotherapy for gross disease (n = 5/17, survival: 29 versus 5 months, P = 0.04) and a smaller number of surgeries preceding radiation therapy (coeff = 0.41, P = 0.03). The Ki67 index was not predictive for survival. We concluded that postsurgical curative and coarse fractionated radiotherapy are effective legitimate options for managing vaccine-associated sarcomas.
authors.affiliation: Diagnostic Imaging and Radio-Oncology, Vetsuisse Faculty University of Zurich, Zurich, Switzerland. ceckstein@vetclinics.uzh.ch
authors.forename: C
authors.initials: C
authors.lastname: Eckstein
authors.forename: F
authors.initials: F
authors.lastname: Guscetti
authors.forename: M
authors.initials: M
authors.lastname: Roos
authors.forename: J
authors.initials: J
authors.lastname: Martín de las Mulas
authors.forename: B
authors.initials: B
authors.lastname: Kaser-Hotz
authors.forename: C
authors.initials: C
authors.lastname: Rohrer Bley
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000209:etiology / Q000401:mortality* / Q000532:radiotherapy*; D002415:Cats; D003131:Combined Modality Therapy; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D019394:Ki-67 Antigen; D008297:Male; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012509:Sarcoma / Q000209:etiology / Q000401:mortality / Q000532:radiotherapy / Q000662:veterinary*; D016019:Survival Analysis; D013557:Switzerland / Q000453:epidemiology; D014612:Vaccines / Q000009:adverse effects
chemical_list: D019394:Ki-67 Antigen; D014612:Vaccines