Acute toxicity of peracetic acid (PAA) formulations to Ichthyophthirius multifiliis theronts.
Peracetic acid (PAA) is an antimicrobial disinfectant used in agriculture, food processing, and medical facilities. It has recently been suggested as a means to control infestations of Ichthyophthirius multifiliis. The purpose of this study was to determine the acute toxicity of two products containing 4.5% and 40% PAA to I. multifiliis theronts from two geographically separate isolates. Theronts were exposed to concentrations of PAA in 96-well plates containing groundwater at 23 degrees C. Acute toxicity was observed over a 4-h period. No significant difference in the median lethal concentration (LC(50)) estimates was evident between the two isolates at 4 h with the 4.5% PAA product (0.146 versus 0.108 mg/l PAA), while there was a statistical difference between the 4 h LC(50) with the 40% PAA product (0.274 versus 0.158 mg/l PAA). These results suggest that PAA is toxic to I. multifiliis theronts at low concentrations and that one of the isolates was more resistant to this compound.
Straus
David L
DL
USDA, Agricultural Research Service, Harry K. Dupree-Stuttgart National Aquaculture Research Center, P.O. Box 1050, Stuttgart, AR 72160, USA. Dave.Straus@ars.usda.gov
Meinelt
Thomas
T
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D002470:Cell Survival; D005399:Fishes / Q000469:parasitology; D016803:Hymenostomatida / Q000187:drug effects* / Q000302:isolation & purification; D007928:Lethal Dose 50; D010463:Peracetic Acid / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D010463:Peracetic Acid