Aneuploidy in abortuses following IVF and ICSI.
OBJECTIVE
To compare aneuploidy rates in first trimester pregnancy losses following IVF+/-ICSI.


METHODS
A retrospective cohort analysis of karyotypes of abortuses following conventional IVF (n=159) and ICSI (n=196).


RESULTS
50.1% of losses were found to be cytogenetically abnormal among all patients undergoing IVF+/-ICSI. A significant increase in fetal aneuploidy rate was noted with increasing maternal age (<30 years=26.1% vs. 31 to 34 years.=38.2% vs. 35 to 39 years.=51.3% vs. >39 years.=65.9%). Aneuploidy rates were similar in the ICSI vs. conventional IVF groups (52.6% vs. 47.2% [p 0.31, RR 1.11, 95% CI 0.90, 1.38]). More sex chromosome anomalies were noted in the ICSI group.


CONCLUSIONS
The aneuploidy rate in first trimester abortuses significantly increases with increasing maternal age. ICSI was not shown to significantly increase the aneuploidy rate. However, more sex chromosome anomalies were found among pregnancies resulting from ICSI.
Kushnir
Vitaly A
VA
New Jersey Medical School, UMDNJ, Dept. of Obstetrics, Gynecology and Women's Health, MSB E-506, 185 South Orange Avenue, Newark, NJ, 07101-1709, USA. vitalykushnir@yahoo.com
Frattarelli
John L
JL
D037881:Aborted Fetus / Q000473:pathology / Q000502:physiology*; D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D000782:Aneuploidy; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D012729:Sex Chromosome Aberrations; D012730:Sex Chromosomes / Q000473:pathology; D020554:Sperm Injections, Intracytoplasmic