title: Minimally invasive flap surgery and enamel matrix derivative in the treatment of localized aggressive periodontitis: case report.
abstract: Localized aggressive periodontitis is a distinct entity of periodontal disease and is characterized by deep vertical bony defects that typically affect the first molars and incisors of young patients. Therapy is usually aimed at reducing the pathogenic microflora through scaling and root planing and the administration of systemic antibiotics. However, conservative periodontal therapy may result in reparative wound healing with limited regeneration of the lost tissues. Periodontal surgery combined with enamel matrix derivative has been introduced as a method to promote regeneration of the lost periodontium and has been studied extensively in the treatment of chronic periodontitis. This case report describes the treatment of a 27-year-old patient displaying severe localized aggressive periodontitis with documented disease progression. After initial therapy consisting of scaling and root planing and systemic administration of amoxicillin and metronidazole, the vertical defects were treated by minimally invasive access flaps combined with application of enamel matrix derivative. Clinical, microbiologic, and radiographic findings are reported for up to 1.5 years after initial therapy, indicating good efficacy of the therapeutic strategy and stability of the treatment outcome.
authors.affiliation: Institute for Periodontology and Synoptic Dentistry, Campus Virchow-Klinikum, Charité-Universitätsmedizin Berlin, Germany. dogan.kaner@charite.de
authors.forename: Doğan
authors.initials: D
authors.lastname: Kaner
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Bernimoulin
authors.forename: Bernd-Michael
authors.initials: BM
authors.lastname: Kleber
authors.forename: Anton
authors.initials: A
authors.lastname: Friedmann
mesh_terms: D000328:Adult; D016976:Aggregatibacter actinomycetemcomitans / Q000302:isolation & purification; D010520:Aggressive Periodontitis / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000601:surgery*; D000658:Amoxicillin / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001861:Bone Regeneration; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000627:therapeutic use; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D013524:Surgical Flaps
chemical_list: D000890:Anti-Infective Agents; D003746:Dental Enamel Proteins; C109069:enamel matrix proteins; D008795:Metronidazole; D000658:Amoxicillin