title: [Clinical presentation, diagnostics and results of primary conservative treatment of large and giant prolactin-secreting pituitary adenomas].
abstract: A prospective study of 55 patients with large and giant prolactin-secreting pituitary tumors receiving dopamine agonists as primary treatment was performed. Statistically significant data were obtained indicating decrease of prolactin level, improvement of vision, normalization of sexual function and shrinking of the tumor. Effectiveness and safety of dopamine agonists in patients with large and giant prolactinomas are proved. Also we discovered possibility of nasal CSF leak during conservative treatment.
authors.forename: L I
authors.initials: LI
authors.lastname: Astaf'eva
authors.forename: B A
authors.initials: BA
authors.lastname: Kadashev
authors.forename: P L
authors.initials: PL
authors.lastname: Kalinin
authors.forename: M A
authors.initials: MA
authors.lastname: Kutin
authors.forename: A N
authors.initials: AN
authors.lastname: Shkarubo
authors.forename: D V
authors.initials: DV
authors.lastname: Fomichev
authors.forename: R B
authors.initials: RB
authors.lastname: Faĭzullaev
authors.forename: S N
authors.initials: SN
authors.lastname: Alekseev
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Sidneva
authors.forename: V D
authors.initials: VD
authors.lastname: Tenedieva
authors.forename: O F
authors.initials: OF
authors.lastname: Tropinskaia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000077465:Cabergoline; D004334:Drug Administration Schedule; D004873:Ergolines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D011388:Prolactin / Q000037:antagonists & inhibitors* / Q000097:blood; D015175:Prolactinoma / Q000175:diagnosis / Q000188:drug therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004873:Ergolines; D011388:Prolactin; D000077465:Cabergoline