Efficient and regioselective halogenations of 2-amino-1,3-thiazoles with copper salts.
Monohalo and dihalo 1,3-thiazole derivatives can be efficiently and selectively prepared under mild conditions from 2-amino-1,3-thiazoles. Halogenations proceed easily in the presence of copper(I) or copper(II) chlorides, bromides, or iodides directly in solution or with supported copper halides.
Siméon
Fabrice G
FG
Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Building 10, Room B3C346A, 10 Center Drive, Bethesda, Maryland 20892-1003, USA. simeonf@intra.nimh.nih.gov
Wendahl
Matthew T
MT
Pike
Victor W
VW
D003300:Copper / Q000737:chemistry*; D054879:Halogenation; D012492:Salts; D013844:Thiazoles / Q000737:chemistry*
D012492:Salts; D013844:Thiazoles; D003300:Copper