[Prognostic role of vascularisation and proliferation in rectal cancer with liver metastasis].
BACKGROUND
The present study was designed to provide an analysis of factors for angiogenesis and proliferation.


METHODS
We analyzed tumor tissues from 37 rectal cancer patients with concurrent or subsequent liver metastasis underwent preoperative radiotherapy, surgery and adjuvant chemotherapy. Immunohistochemistry was used for expression of proliferation (staining with anti-Ki67: MIB-1) and for detection of microvessel density (MVD, expressed by CD34). Clinicopathological findings were compared with outcome with emphasis to IHC.


RESULTS
A vascular enumeration and pN status and the time of presence of the metastases has shown prognostic role along with the factors above. Increased proliferative activity of the tumor as expressed by MIB-1 staining has no prognostic value, similarly to the localization of tumor, gender, age or grading.


CONCLUSIONS
Different prognostic and predictive factors in colorectal cancer have been reported. Higher pN status and tumor vascularisation has been linked to poor prognosis in overall survival and tumor recurrence.
Bognár
Gábor
G
Semmelweis Egyetem, Altalános Orvostudományi Kar II. sz. Sebészeti Klinika, Budapest. bgabor@kut.sote.hu
Imdahl
Andreas
A
Bereczky
Bíborka
B
Ledniczky
György
G
István
Gábor
G
Tóth
Eva Katalin
EK
Ihling
Christian
C
Ondrejka
Pál
P
D000230:Adenocarcinoma / Q000098:blood supply* / Q000401:mortality / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models
D014408:Biomarkers, Tumor