title: The preventive effect of fermented milk supplement containing tomato (lycopersion esculentum) and taurine on bone loss in ovariectomized rats.
abstract: This study was conducted to examine the preventive effects of fermented milk supplement with tomato and taurine on bone loss in ovariectomized rats. Twenty-seven female Sprague-Dawley rats weighing 200g were ovariectomized and then were randomly assigned to three groups (OVX, ovariectomized and fed a low calcium diet; OVX-C, ovariectomized control; OVX+TS, ovariectomized and fed fermented milk supplement with tomato). Each group was fed a low calcium diet for three weeks. After three weeks, the OVX group was sacrificed and the other groups were fed an experimental diet for 4 weeks. Length, weight and calcium levels of the femur and lumbar in the OVX+TS group were significantly elevated compared to those of the OVX group. Bone mass, breaking force and bone mineral density (BMD) of femur of the OVX+TS group were significantly greater than that of the OVX-C group. Serum alkaline phosphatase activity (ALP) was highest in the OVX-C group. Therefore, our findings suggest that fermented milk supplemented with tomato and taurine might improve bone health in postmenopausal osteoporotic rats.
authors.affiliation: Department of Food and Nutrition, Inha University, Incheon, Korea.
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Cheong
authors.forename: Kyung Ja
authors.initials: KJ
authors.lastname: Chang
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001835:Body Weight; D015519:Bone Density; D005260:Female; D005285:Fermentation; D018551:Solanum lycopersicum; D008892:Milk; D009929:Organ Size; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000517:prevention & control*; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000008:administration & dosage*
chemical_list: D015675:Osteocalcin; D013654:Taurine; D000469:Alkaline Phosphatase