title: Incidental thyroid nodule: patterns of diagnosis and rate of malignancy.
abstract: BACKGROUND
  The clinical significance of thyroid incidentalomas is controversial.
  
  
  METHODS
  The rate of malignancy was determined for patients with an incidentally discovered thyroid nodule, and results were stratified according to imaging modality as well as presence and type of pre-existing malignancy.
  
  
  RESULTS
  One hundred fifty patients were identified, of which 88 with a known malignancy were screened for metastases. Twenty-three (15%) patients were diagnosed with thyroid malignancy. Incidental nodules identified on positron emission tomography scan were malignant in 33% of the patients compared with 11% for those identified on computed axial tomography (P = .016). The rate of thyroid malignancy in patients with pre-existing nonthyroid malignancy (18%) was not significantly different from patients without a history of malignancy (13%, P = .36).
  
  
  CONCLUSIONS
  Thyroid incidentalomas are associated with a high rate of malignancy. The rate of malignancy is highest for nodules discovered on positron emission tomography scan and is no different in patients with or without pre-existing malignancy.
authors.affiliation: Department of Surgery, University Hospitals Case Medical Center, School of Medicine, Cleveland, OH, USA.
authors.forename: Judy
authors.initials: J
authors.lastname: Jin
authors.forename: Scott M
authors.initials: SM
authors.lastname: Wilhelm
authors.forename: Christopher R
authors.initials: CR
authors.lastname: McHenry
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis* / Q000453:epidemiology; D049268:Positron-Emission Tomography; D016606:Thyroid Nodule / Q000175:diagnosis* / Q000453:epidemiology; D014057:Tomography, X-Ray Computed; D055815:Young Adult