An elevated value of high mobility group box 1 is a potential marker for poor response to high-dose of intravenous immunoglobulin treatment in patients with Kawasaki syndrome.
We examined the serum values of high mobility group box 1 (HMGB1) in 36 patients with Kawasaki syndrome (KS) (29 responders and 7 poor-responders to initial intravenous immunoglobulin treatment). A mean value of HMGB1 of poor-responders was significantly elevated compared with those of responders (P = 0.0042). Among the 6 factors showing significant differences between responders and poor-responders including HMGB1 (admission illness day, white blood cell counts, C-reactive protein, aspartate aminotransferase, lactate dehydrogenase), values of HMGB1 showed the widest area under the receiver operating characteristic curve. In conclusion, an elevated HMGB1 value could be a potential marker for poor-responders.
Eguchi
Taisuke
T
Division of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
Nomura
Yuichi
Y
Hashiguchi
Teruto
T
Masuda
Kiminori
K
Arata
Michiko
M
Hazeki
Daisuke
D
Ueno
Kentaro
K
Nishi
Junichiro
J
Kawano
Yoshifumi
Y
Maruyama
Ikuro
I
D015415:Biomarkers; D002675:Child, Preschool; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D012372:ROC Curve; D018709:Statistics, Nonparametric
D015415:Biomarkers; D024243:HMGB1 Protein; D016756:Immunoglobulins, Intravenous