title: Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells.
abstract: Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.
authors.affiliation: Departamento de Química Inorgánica y Orgánica/UAMOA, Universitat Jaume I/CSIC, Av. Sos Baynat, s/n, 12071, Castellón, Spain.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Burguete
authors.forename: Francisco
authors.initials: F
authors.lastname: Galindo
authors.forename: Raquel
authors.initials: R
authors.lastname: Gavara
authors.forename: Santiago V
authors.initials: SV
authors.lastname: Luis
authors.forename: Miguel
authors.initials: M
authors.lastname: Moreno
authors.forename: Paul
authors.initials: P
authors.lastname: Thomas
authors.forename: David A
authors.initials: DA
authors.lastname: Russell
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D018613:Microscopy, Confocal; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D026082:Singlet Oxygen / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D026082:Singlet Oxygen