title: Determination of the effects of blood depth in the dermis on skin colour in a novel skin phantom using digital imaging.
abstract: A phantom of human port wine stain (PWS) skin, previously described by the authors, that takes into account its light propagation and scattering properties, was used to model varying depths of blood within PWS skin. Digital images of these phantoms were then acquired under controlled conditions, and the colour information was abstracted with a digital image processing suite. These colour data were analysed quantitatively for each depth of blood, and the relationship between depth of blood and colour was defined. A linear relationship was observed between depth of blood within the phantom and hue, hue being an intuitive measure of how colour is perceived by the human eye. As PWS clearance by laser treatment is dependant, to a large degree, on vessel depth within the skin, the ability to abstract colour data from PWS or, in fact, any vascular lesion within the skin, may help predict the degree of clearance before treatment is actually instigated. In the future, the comparison of phantom colour data with data from actual digital images of affected PWS skin, combined with a knowledge of laser light penetration depths, may provide a useful adjunct to clinical judgement in the prediction of PWS treatment outcomes.
authors.affiliation: Wessex Specialist Laser Centre, Department of Plastic and Reconstructive Surgery, Salisbury District Hospital, Salisbury, Wiltshire, UK. danielwiddowson@hotmail.com
authors.forename: D C
authors.initials: DC
authors.lastname: Widdowson
authors.forename: J C
authors.initials: JC
authors.lastname: Moore
authors.forename: P A
authors.initials: PA
authors.lastname: Wright
authors.forename: P G
authors.initials: PG
authors.lastname: Shakespeare
mesh_terms: D020405:Dermis / Q000098:blood supply* / Q000473:pathology*; D006801:Humans; D019047:Phantoms, Imaging; D010781:Photography / Q000379:methods* / Q000706:statistics & numerical data; D019339:Port-Wine Stain / Q000473:pathology*; D012880:Skin Pigmentation