title: Sodium concentration in rehydration fluids for children with ketoacidotic diabetes: effect on serum sodium concentration.
abstract: OBJECTIVE
  To analyze in a retrospective cohort if sodium concentration in the rehydration fluids influence natremia in children with diabetic ketoacidosis (DKA).
  
  
  METHODS
  Consecutive episodes of diabetic ketoacidosis admitted in a tertiary care referral center from 2000 to 2005. Rehydration was programmed for 48 hours with a 2-bag system. Initial rehydration was performed with isotonic fluids and thereafter with variable tonicity. Analysis of the influence of the different factors on natremia was performed with a multivariate linear regression analysis.
  
  
  RESULTS
  Forty-two episodes of DKA were reviewed. Increased sodium content in rehydration fluids behaved as an independent variable, causing a positive tendency of natremia (P < .008).
  
  
  CONCLUSIONS
  Sodium concentration in the rehydration fluids behaves as an independent factor that influences positively the trend of the serum concentration of sodium during DKA rehydration. We propose the use of isotonic solutions for rehydration in diabetic ketoacidosis.
authors.affiliation: Pediatric Intensive Care Unit, Children's Hospital La Fe, Valencia, Spain.
authors.forename: Juan Diego
authors.initials: JD
authors.lastname: Toledo
authors.forename: Vicente
authors.initials: V
authors.lastname: Modesto
authors.forename: Magdalena
authors.initials: M
authors.lastname: Peinador
authors.forename: Pablo
authors.initials: P
authors.lastname: Alvarez
authors.forename: José Luis
authors.initials: JL
authors.lastname: López-Prats
authors.forename: Ramón
authors.initials: R
authors.lastname: Sanchis
authors.forename: Máximo
authors.initials: M
authors.lastname: Vento
mesh_terms: D000293:Adolescent; D001929:Brain Edema / Q000209:etiology / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D007552:Isotonic Solutions; D008297:Male; D015532:Rehydration Solutions / Q000737:chemistry* / Q000627:therapeutic use; D012964:Sodium / Q000032:analysis* / Q000097:blood*
chemical_list: D007552:Isotonic Solutions; D015532:Rehydration Solutions; D012964:Sodium