title: Cardiovascular risk attributable to diabetes in southern Brazil: a population-based cohort study.
abstract: OBJECTIVE
  To analyze the effect of diabetes on general and cardiovascular disease (CVD) mortality and morbidity in southern Brazil.
  
  
  METHODS
  A population-based cohort study of 1,091 individuals was conducted. Diabetes was ascertained by medical history. The vital status of 982 individuals and the incidence of events were ascertained during another visit and through hospital records, death certificates, and verbal necropsy with relatives.
  
  
  RESULTS
  The mean +/- SD age of participants was 43.1 +/- 17 years, and 55.7% were women. The prevalence of diabetes was 4.2%, and the mean follow-up time was 5.3 +/- 0.07 years. Mortality was 36.3% and 6.6% in participants with or without diabetes, respectively; the incidence of CVD was 20.8% and 3.0%, with an adjusted hazard ratio of 4.4 (95% CI 2.4-7.9). Diabetic population-attributable risk (PAR) for CVD mortality was 10.1% and 13.1% for total CVD.
  
  
  CONCLUSIONS
  Diabetes is responsible for a large PAR for overall mortality and cardiovascular events in Brazil.
authors.affiliation: Department of Pharmacology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. lbmoreira@hcpa.ufrgs.br
authors.forename: Leila B
authors.initials: LB
authors.lastname: Moreira
authors.forename: Sandra C
authors.initials: SC
authors.lastname: Fuchs
authors.forename: Mário
authors.initials: M
authors.lastname: Wiehe
authors.forename: Jeruza L
authors.initials: JL
authors.lastname: Neyeloff
authors.forename: Rafael V
authors.initials: RV
authors.lastname: Picon
authors.forename: Marina B
authors.initials: MB
authors.lastname: Moreira
authors.forename: Miguel
authors.initials: M
authors.lastname: Gus
authors.forename: Flávio D
authors.initials: FD
authors.lastname: Fuchs
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000401:mortality; D015331:Cohort Studies; D003925:Diabetic Angiopathies / Q000453:epidemiology* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment