title: A prospective evaluation of the diagnostic value of video capsule endoscopy in patients initially classified as irritable bowel syndrome.
abstract: BACKGROUND
  Irritable bowel syndrome (IBS) is characterized by chronic gastrointestinal dysfunction in the absence of detectable organic disease. The recently developed technique, video capsule endoscopy (CE), has been shown to be much more sensitive than traditional enterography in detecting mucosal changes in the small intestine. This study was performed to see if any earlier, not detectable by other standard methods, mucosal changes could be found in the small intestine in patients diagnosed as having IBS.
  
  
  METHODS
  All consecutive women who, over the past five years, had received a well-founded diagnosis of IBS at the Department of Medicine were identified. Twenty-eight women, mean age 36+/-12 years were willing to participate in the study. They underwent a CE after a pre-test with a dummy capsule. The actual IBS activity was estimated by the validated Gastrointestinal Symptom Rating Scale (GSRS) and Psychological General Well-Being (PGWB) Index questionnaires.
  
  
  RESULTS
  The duration of the IBS symptoms was a mean of 10 years (range 3-25). Symptoms were present, according to the scores of the GSRS and the PGWB index, at the time the patients underwent the CE. In the majority, 24 of 27 IBS patients examined, no specific small intestinal lesions were seen on CE. In two patients, CE revealed multiple small intestinal lesions such as ulcerations and/or erosions, and in one patient a duodenal ulceration.
  
  
  CONCLUSIONS
  In the vast majority of patients who fulfil the symptom criteria of IBS, no pathological mucosal lesions can be found by CE explaining the symptomatology. However, a subgroup of these patients may benefit from investigation by CE to reconsider the diagnosis.
authors.affiliation: Department of Clinical Sciences, Division of Gastroenterology and Hepatology, Malmö University Hospital, Lund University, Sweden. bodil.ohlsson@med.lu.se
authors.forename: Bodil
authors.initials: B
authors.lastname: Ohlsson
authors.forename: Mariette
authors.initials: M
authors.lastname: Bengtsson
authors.forename: Jörgen
authors.initials: J
authors.lastname: Nielsen
authors.forename: Ervin
authors.initials: E
authors.lastname: Toth
mesh_terms: D000328:Adult; D053704:Capsule Endoscopy / Q000592:standards*; D004381:Duodenal Ulcer / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006304:Health Status; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D043183:Irritable Bowel Syndrome / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D011795:Surveys and Questionnaires; D055815:Young Adult