title: A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin alpha(v)beta(3).
abstract: A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.
authors.affiliation: Department of Chemistry & Laboratory of Advanced Materials, Fudan University, Shanghai 200433, P. R. China.
authors.forename: Liqin
authors.initials: L
authors.lastname: Xiong
authors.forename: Mengxiao
authors.initials: M
authors.lastname: Yu
authors.forename: Mingjun
authors.initials: M
authors.lastname: Cheng
authors.forename: Meng
authors.initials: M
authors.lastname: Zhang
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhang
authors.forename: Congjian
authors.initials: C
authors.lastname: Xu
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li
mesh_terms: D000165:Acridine Orange; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000378:metabolism*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D039302:Integrin alphaVbeta3 / Q000378:metabolism*; D008027:Light; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000378:metabolism*; D038761:Photobleaching; D013056:Spectrophotometry, Ultraviolet
chemical_list: D005456:Fluorescent Dyes; D039302:Integrin alphaVbeta3; D000165:Acridine Orange