Antianaerobic activity of sulopenem compared to six other agents.
Agar dilution MIC methodology was used to compare the activity of sulopenem with those of amoxicillin/clavulanate, ampicillin/sulbactam, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 431 anaerobes. Overall, MIC(50)/(90) values were as follows: sulopenem, 0.25/1.0 microg/ml; amoxicillin/clavulanate, 0.5/2.0 microg/ml; ampicillin/sulbactam, 0.5/4.0 microg/ml; piperacillin/tazobactam, 0.25/8.0 microg/ml; imipenem, 0.06/1.0 microg/ml; clindamycin, 0.25/16.0 microg/ml; and metronidazole, 1.0/4.0 microg/ml.
Ednie
Lois M
LM
Department of Pathology, Hershey Medical Center, P.O. Box 850, Hershey, PA 17033, USA.
Appelbaum
Peter C
PC
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001421:Bacteria, Anaerobic / Q000187:drug effects*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D007769:Lactams / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests / Q000379:methods / Q000592:standards; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D007769:Lactams; D011355:Prodrugs; C082897:sulopenem