title: Effects of neolignans from the stem bark of Magnolia obovata on plant pathogenic fungi.
abstract: OBJECTIVE
  To characterize antifungal principles from the methanol extract of Magnolia obovata and to evaluate their antifungal activities against various plant pathogenic fungi.
  
  
  RESULTS
  Four neolignans were isolated from stem bark of M. obovata as antifungal principles and identified as magnolol, honokiol, 4-methoxyhonokiol and obovatol. In mycelial growth inhibition assay, both magnolol and honokiol displayed more potent antifungal activity than 4-methoxyhonokiol and obovatol. Both magnolol and honokiol showed similar in vivo antifungal spectrum against seven plant diseases tested; both compounds effectively suppressed the development of rice blast, tomato late blight, wheat leaf rust and red pepper anthracnose. 4-Methoxyhonokiol and obovatol were highly active to only rice blast and wheat leaf rust respectively.
  
  
  CONCLUSIONS
  The extract of M. obovata and four neolignans had potent in vivo antifungal activities against plant pathogenic fungi.
  
  
  CONCLUSIONS
  Neolignans from Magnolia spp. can be used and suggested as a novel antifungal lead compound for the development of new fungicide and directly as a natural fungicide for the control of plant diseases such as rice blast and wheat leaf rust.
authors.affiliation: Chemical Biotechnology Research Center, Korea Research Institute of Chemical Technology, Daejeon, Korea.
authors.forename: N H
authors.initials: NH
authors.lastname: Choi
authors.forename: G J
authors.initials: GJ
authors.lastname: Choi
authors.forename: B-S
authors.initials: BS
authors.lastname: Min
authors.forename: K S
authors.initials: KS
authors.lastname: Jang
authors.forename: Y H
authors.initials: YH
authors.lastname: Choi
authors.forename: M S
authors.initials: MS
authors.lastname: Kang
authors.forename: M S
authors.initials: MS
authors.lastname: Park
authors.forename: J E
authors.initials: JE
authors.lastname: Choi
authors.forename: B K
authors.initials: BK
authors.lastname: Bae
authors.forename: J-C
authors.initials: JC
authors.lastname: Kim
mesh_terms: D000498:Allyl Compounds; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001713:Biphenyl Compounds; D002855:Chromatography, Thin Layer; D005658:Fungi / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031566:Magnolia / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D025282:Mycelium / Q000187:drug effects; D010647:Phenyl Ethers; D024301:Plant Bark / Q000737:chemistry; D010935:Plant Diseases; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010636:Phenols
chemical_list: D000498:Allyl Compounds; D000935:Antifungal Agents; D001713:Biphenyl Compounds; D017705:Lignans; D010647:Phenyl Ethers; D010936:Plant Extracts; C531035:4-methoxyhonokiol; C005498:magnolol; C005499:honokiol; D010636:Phenols; C036795:obovatol