A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres.
A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5), were isolated from a culture of marine-derived fungus Aspergillus fumigatus Fres. The structure of 1 was determined on the basis of spectroscopic methods. All five compounds were evaluated for the cytotoxic effects on tsFT210 cell line by the SRB method.
Zhao
Wen Ying
WY
Key Laboratory of Marine Drugs, Ministry of Education, Marine Drugs and Food Institute, Ocean University of China, Qingdao, China.
Zhu
Tian Jiao
TJ
Han
Xiao Xian
XX
Fan
Guo Tao
GT
Liu
Hong Bing
HB
Zhu
Wei Ming
WM
Qun Gu
Qian
Q
D000818:Animals; D001232:Aspergillus fumigatus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005912:Gliotoxin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure
D005912:Gliotoxin