title: Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome.
abstract: BACKGROUND
  A significant proportion of the first-degree female relatives of women with polycystic ovary syndrome (PCOS) may be at risk for developing PCOS. However, it is not known at which stage of pubertal development the hormonal and metabolic abnormalities ensue in PCOS.
  
  
  OBJECTIVE
  The aim of the study was to assess the reproductive and metabolic profiles of daughters of women with PCOS (PCOSd) during the peripubertal period, a stage during which the gonadal axis is activated and PCOS may become clinically manifest.
  
  
  METHODS
  Ninety-nine PCOSd [30 prepubertal and 69 pubertal (Tanner II-V)] and 84 daughters of control women (Cd) (20 prepubertal and 64 pubertal) were studied. An oral glucose tolerance test, a GnRH agonist test (leuprolide acetate, 10 microg/kg sc), and a transabdominal ultrasound were performed. Gonadotropins, sex steroids, SHBG, glucose, insulin, and lipids were determined.
  
  
  RESULTS
  Both groups had similar chronological ages and body mass index sd scores according to Tanner stage distribution. Ovarian volume and 2-h insulin were significantly higher in PCOSd compared to Cd at all Tanner stages. In Tanner stages IV and V, basal testosterone and poststimulated LH, testosterone, and 17-hydroxyprogesterone concentrations were significantly higher in PCOSd compared to Cd.
  
  
  CONCLUSIONS
  Hyperinsulinemia and an increased ovarian volume are present in PCOSd before the onset of puberty and persist during pubertal development. The biochemical abnormalities of PCOS appear during late puberty. Considering the early onset and the nature of the alterations, PCOSd constitute a high-risk group for metabolic and reproductive derangements.
authors.affiliation: Endocrinology and Metabolism Laboratory, Department of Medicine, West Division, School of Medicine, Las Palmeras 299, Interior Quinta Normal, Casilla 33052, Correo 33, Santiago 8320000, Chile. tsir@med.uchile.cl
authors.forename: Teresa
authors.initials: T
authors.lastname: Sir-Petermann
authors.forename: Ethel
authors.initials: E
authors.lastname: Codner
authors.forename: Virginia
authors.initials: V
authors.lastname: Pérez
authors.forename: Bárbara
authors.initials: B
authors.lastname: Echiburú
authors.forename: Manuel
authors.initials: M
authors.lastname: Maliqueo
authors.forename: Amanda
authors.initials: A
authors.lastname: Ladrón de Guevara
authors.forename: Jessica
authors.initials: J
authors.lastname: Preisler
authors.forename: Nicolás
authors.initials: N
authors.lastname: Crisosto
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez
authors.forename: Fernando
authors.initials: F
authors.lastname: Cassorla
authors.forename: Shalender
authors.initials: S
authors.lastname: Bhasin
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D016241:Child of Impaired Parents; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009679:Nuclear Family; D011085:Polycystic Ovary Syndrome; D011627:Puberty / Q000097:blood / Q000378:metabolism* / Q000502:physiology*; D012098:Reproduction / Q000502:physiology*; D013739:Testosterone / Q000032:analysis / Q000097:blood
chemical_list: D013739:Testosterone