title: Recurrent spindle cell oncocytoma of the pituitary, a case report and review of literature.
abstract: Spindle cell oncocytoma (SCO) is a rare non-functioning tumour of the pituitary which has just been formally recognized as a distinct entity by the 2007 WHO classification of brain tumours. We report a case of SCO who presented with symptoms of visual blurring, weight loss, intermittent vomiting and excessive tiredness of several months duration. Investigations revealed a bitemporal visual field defect, a panhypopituitary hormonal profile and a large pituitary tumour with suprasellar extension. He underwent a successful trans-sphenoidal resection of the pituitary tumour but it subsequently recurred twice at 9 months interval which required further two debulking procedures. A diagnosis of SCO was made based on its unique histologic and staining properties. To date there are only ten reported cases of SCO in total with only two of these cases being recurrent. Our case displayed the most aggressive clinical course despite having a low Ki-67 index contrary to the previously reported cases of recurrent SCO.
authors.affiliation: Department of Endocrinology, Lancashire Teaching Hospitals NHS Foundation Trust, Fullwood, Preston, UK. ydneguss@yahoo.co.uk
authors.forename: Yared N
authors.initials: YN
authors.lastname: Demssie
authors.forename: Jacob
authors.initials: J
authors.lastname: Joseph
authors.forename: Timothy
authors.initials: T
authors.lastname: Dawson
authors.forename: Gareth
authors.initials: G
authors.lastname: Roberts
authors.forename: John
authors.initials: J
authors.lastname: de Carpentier
authors.forename: Simon
authors.initials: S
authors.lastname: Howell
mesh_terms: D018249:Adenoma, Oxyphilic / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012196:Review Literature as Topic