title: Association of polymorphisms in interferon regulatory factor 5 gene with rheumatoid arthritis: a metaanalysis.
abstract: OBJECTIVE
  We investigated potential associations between rheumatoid arthritis (RA) and interferon regulatory factor 5 (IRF5) polymorphisms in a metaanalysis.
  
  
  METHODS
  This metaanalysis included 5 case-control studies, which provided a total of 6582 RA cases and 5375 controls. Odds ratios (OR) were employed to evaluate the risk of RA according to the 4 single-nucleotide polymorphisms (SNP) in IRF5 (rs729302, rs2004640, rs752637, and rs2280714) and data were analyzed in respect to association between alleles.
  
  
  RESULTS
  Among 4 candidate SNP, rs729302, rs2004640, and rs2280714 were statistically significant; both allele C of rs729302 and allele G of rs2004640 within the promoter region of IRF5 were associated with a protective effect [random-effects (RE) OR 0.889, 95% confidence interval (CI) 0.803-0.977, p=0.015 for rs729302; and RE OR 0.905, 95% CI 0.848-0.965, p=0.002 for rs2004640]. Similar results were also obtained in T allele of rs2280714 in the 3'-untranslated region (RE OR 0.927, 95% CI 0.866-0.992, p=0.029). There was no evidence of publication bias from funnel-plot asymmetry and Egger's regression test.
  
  
  CONCLUSIONS
  Our metaanalysis supported the evidence of the significant role of IRF5 polymorphisms in RA.
authors.affiliation: The Center of Rheumatology, Department of Internal Medicine, Daegu Fatima Hospital, and Department of Preventive Medicine, Kyungpook National University School of Medicine, 576-13, Sinam 4 dong, Donggu, Daegu, 701-010, Republic of Korea.
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Han
authors.forename: Won Ki
authors.initials: WK
authors.lastname: Lee
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Kwon
authors.forename: Byung Ki
authors.initials: BK
authors.lastname: Lee
authors.forename: Eon Jeong
authors.initials: EJ
authors.lastname: Nam
authors.forename: Gun Woo
authors.initials: GW
authors.lastname: Kim
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology; D016208:Databases, Factual; D014644:Genetic Variation; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics* / Q000276:immunology; D051379:Mice; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: C431713:IRF5 protein, human; D050835:Interferon Regulatory Factors