The ubiquitin-proteasome pathway and IgA nephropathy: a novel link?
Proteasomal degradation of intracellular proteins facilitates the recognition of foreign proteins through interactions with major histocompatibility complex molecules presented to T cells. Interferon-gamma enhances the efficiency of this antigen presentation process by inducing a switch of proteasome to immunoproteasome catalytic subunits. The finding that immunoproteasomes are upregulated in IgA nephropathy may prompt further exploration of the role and mechanism of proteasome activation and intensify the quest for infectious agents that may induce IgA nephritis.
Tang
Sydney C W
SC
Department of Medicine, Division of Nephrology, University of Hong Kong, Hong Kong, China. scwtang@hku.hk
Lai
Kar Neng
KN
D017951:Antigen Presentation; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D025801:Ubiquitin / Q000378:metabolism*; D015854:Up-Regulation
D025801:Ubiquitin; D046988:Proteasome Endopeptidase Complex