title: Path dependence of three-phase or two-phase end points in fluid binary lipid mixtures.
abstract: The phase behavior of anionic/zwitterionic mixtures can be controlled by tuning the charge state of the anionic lipid. In the case of dioleoylphosphatidic acid (DOPA)/dioleoylphosphatidylcholine (DOPC) mixtures, demixing occurs either when DOPA is protonated or when DOPA(2-):Ca(2+) complexes form. Herein it will be shown that the final end point, a three-phase or two-phase system, depends on the order in which the charge state is manipulated. The facile accessibility of different end points is a clear demonstration of the inherent flexibility of biological systems.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: Emily R
authors.initials: ER
authors.lastname: Lamberson
authors.forename: Lee R
authors.initials: LR
authors.lastname: Cambrea
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Rochet
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Hovis
mesh_terms: D000465:Algorithms; D002118:Calcium / Q000737:chemistry; D004926:Escherichia coli / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D010712:Phosphatidic Acids / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; C037657:dioleoylphosphatidic acid; C017251:1,2-oleoylphosphatidylcholine; D002118:Calcium