title: Significant steroids: effective and general synthesis of 4alpha- and 4beta-amino-5alpha-androstanes.
abstract: 4alpha-Aminosteroids were synthesized by the substitution of a 2alpha-bromo ketone using K(2)CO(3) as an activator; 4beta-aminosteroids were synthesized in excellent yields by a highly regioselective and trans-stereospecific ring opening of a steroidal 3,4alpha-epoxide using ZnCl(2)-H(2)O as a catalyst.
authors.affiliation: State Key Laboratory of Virology, College of Pharmacy, Wuhan University, Wuhan, P. R. China.
authors.forename: Xianbing
authors.initials: X
authors.lastname: Ke
authors.forename: Hao
authors.initials: H
authors.lastname: Hu
authors.forename: Keda
authors.initials: K
authors.lastname: Zhang
authors.forename: Wenjin
authors.initials: W
authors.lastname: Xu
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Zhu
authors.forename: Lamei
authors.initials: L
authors.lastname: Wu
authors.forename: Xianming
authors.initials: X
authors.lastname: Hu
mesh_terms: D000731:Androstanes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry
chemical_list: D000731:Androstanes; D007659:Ketones; D013256:Steroids; D015032:Zinc