Trypanocidal activity of abietane diterpenoids from the roots of Craniolaria annua.
A chloroform extract from roots of Craniolaria annua provided six new C-11 unsubstituted abietanes, 14-hydroxy-6,12-dione-7,9(11),13-abietatriene (1), 14-hydroxy-12-oxo-7,9(11),13-abietatriene (2), 6,12,14-trihydroxyabieta-5,8,11,13-tetraen-7-one (3), ar-abietatriene-12-ol-6,7-dione-14,16-oxide (4), ar-abietatriene-12,16-diol-14,16-oxide (5) and ar-abietatriene-12-ol-7-one-14,16-oxide (6), and two known compounds, ferruginol and stigmasterol. The structures of both the new and known compounds were established by spectroscopic methods. Abietane 1 gave 14-hydroxy-6-oxoferruginol (1A) upon treatment with NaBH4. Abietanes 1, 1A, 3-5 and ferruginol showed cytotoxic effects against trypomastigote and epimastigote forms of Trypanosoma cruzi and against fibroblastic Vero cells.
Herrera
Julio C
JC
Departamento de Química, Universidad Simón Bolívar, Apartado 89000, Caracas 1080a, Venezuela. cherrera@usb.ve
Troncone
Graciela
G
Henríquez
Diana
D
Urdaneta
Neudo
N
D045784:Abietanes / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D019686:Lamiaceae / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D013053:Spectrophotometry; D014344:Trypanocidal Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D014709:Vero Cells / Q000187:drug effects*
D045784:Abietanes; D014344:Trypanocidal Agents