title: iMembrane: homology-based membrane-insertion of proteins.
abstract: iMembrane is a homology-based method, which predicts a membrane protein's position within a lipid bilayer. It projects the results of coarse-grained molecular dynamics simulations onto any membrane protein structure or sequence provided by the user. iMembrane is simple to use and is currently the only computational method allowing the rapid prediction of a membrane protein's lipid bilayer insertion. Bilayer insertion data are essential in the accurate structural modelling of membrane proteins or the design of drugs that target them.
authors.affiliation: Department of Statistics, University of Oxford, Oxford, UK. kelm@stats.ox.ac.uk
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kelm
authors.forename: Jiye
authors.initials: J
authors.lastname: Shi
authors.forename: Charlotte M
authors.initials: CM
authors.lastname: Deane
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D030562:Databases, Protein; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D017386:Sequence Homology, Amino Acid; D012984:Software
chemical_list: D008051:Lipid Bilayers; D008565:Membrane Proteins