title: The use of gel dosimetry to measure the 3D dose distribution of a 90Sr/90Y intravascular brachytherapy seed.
abstract: Absorbed dose distributions in 3D imparted by a single (90)Sr/(90)Y beta particle seed source of the type used for intravascular brachytherapy were investigated. A polymer gel dosimetry medium was used as a dosemeter and phantom, while a special high-resolution laser CT scanner with a spatial resolution of 100 microm in all dimensions was used to quantify the data. We have measured the radial dose function, g(L)(r), observing that g(L)(r) increases to a maximum value and then decreases as the distance from the seed increases. This is in good agreement with previous data obtained with radiochromic film and thermoluminescent dosemeters (TLDs), even if the TLDs underestimate the dose at distances very close to the seed. Contrary to the measurements, g(L)(r) calculated through Monte Carlo simulations and reported previously steadily decreases without a local maximum as a function of the distance from the seed. At distances less than 1.5 mm, differences of more than 20% are observed between the measurements and the Monte Carlo calculations. This difference could be due to a possible underestimation of the energy absorbed into the seed core and encapsulation in the Monte Carlo simulation, as a consequence of the unknown precise chemical composition of the core and its respective density for this seed. The results suggest that g(L)(r) can be measured very close to the seed with a relative uncertainty of about 1% to 2%. The dose distribution is isotropic only at distances greater than or equal to 2 mm from the seed and is almost symmetric, independent of the depth. This study indicates that polymer gel coupled with the special small format laser CT scanner are valid and accurate methods for measuring the dose distribution at distances close to an intravascular brachytherapy seed.
authors.affiliation: Ionizing Radiation Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA. massillon@fisica.unam.mx
authors.forename: G
authors.initials: G
authors.lastname: Massillon-Jl
authors.forename: R
authors.initials: R
authors.lastname: Minniti
authors.forename: M G
authors.initials: MG
authors.lastname: Mitch
authors.forename: M J
authors.initials: MJ
authors.lastname: Maryanski
authors.forename: C G
authors.initials: CG
authors.lastname: Soares
mesh_terms: D001808:Blood Vessels / Q000528:radiation effects*; D001918:Brachytherapy / Q000379:methods*; D005782:Gels; D007834:Lasers; D011109:Polymethacrylic Acids; D011829:Radiation Dosage; D011874:Radiometry / Q000379:methods*; D011879:Radiotherapy Dosage; D013326:Strontium Radioisotopes / Q000627:therapeutic use*; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
chemical_list: D005782:Gels; D011109:Polymethacrylic Acids; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes; C030613:polymethacrylic acid