Palladium-103 ophthalmic plaque radiation therapy for choroidal melanoma: 400 treated patients.
OBJECTIVE
To describe 18 years of experience with palladium-103 ((103)Pd) ophthalmic plaque brachytherapy.


METHODS
Retrospective case series.


METHODS
From 1990 to 2007, 400 patients were diagnosed with uveal melanoma, found negative for metastatic disease, and treated. Episcleral (103)Pd radiation was delivered to a mean apical radiation dose of 73.3 Gy over 5 to 7 continuous days.


METHODS
Palladium-103 ophthalmic plaque brachytherapy.


METHODS
Patients were evaluated for local tumor control, visual acuity, radiation damage (retinopathy, optic neuropathy, cataract), and metastatic disease.


RESULTS
A total of 272 tumors (68%) were located at or posterior to the equator. There were 186 (46.5%) T1 tumors, 156 (39%) T2 tumors, 50 (12.5%) T3 tumors, and 8 (2%) T4 tumors. Patients were followed for a maximum of 205 months (mean, 51.1 months). Fourteen patients required secondary enucleation (5 for tumor growth and 9 for glaucoma pain control). The local control rate was 96.7%. Life table analysis of patients with 20/200 or better before treatment (n = 357) suggests that 79% and 69% are expected to retain that acuity for 5 and 10 years, respectively. Life table analysis demonstrates a probability that 92.7% and 86.6% of patients will be free of metastatic disease at 5 and 10 years, respectively.


CONCLUSIONS
In a nonrandomized phase I clinical evaluation, (103)Pd ophthalmic plaque radiotherapy was used to treat 400 patients with uveal melanoma. In this series, results after (103)Pd ophthalmic plaque radiotherapy were superior to those reported for alternative forms of radiation.
Finger
Paul T
PT
The New York Eye Cancer Center, New York, New York 10065, USA. pfinger@eyecancer.com
Chin
Kimberly J
KJ
Duvall
Greg
G
D001918:Brachytherapy / Q000379:methods*; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D008545:Melanoma / Q000175:diagnosis / Q000401:mortality / Q000532:radiotherapy*; D009887:Ophthalmoscopy; D010165:Palladium / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000175:diagnosis; D011868:Radioisotopes / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014792:Visual Acuity
D011868:Radioisotopes; D010165:Palladium