General chromatographic NMR method in liquid state for synthetic chemistry: polyvinylpyrrolidone assisted DOSY experiments.
A polymer assisted liquid state DOSY NMR technique, to extract the spectra of the individual components from mixtures in CDCl(3), is demonstrated. The enhancement of diffusion coefficient differences is achieved using a soluble polymer, polyvinylpyrrolidone, as the "stationary phase". The "separation" of analytes resembles normal-phase chromatography, for example, TLC. This method provides a fast, cheap, and simple technique to resolve the NMR spectra of complex mixtures.
Kavakka
Jari S
JS
Laboratory of Organic Chemistry, Department of Chemistry, University of Helsinki, P.O. Box 55, FIN-00014, University of Helsinki, Finland.
Kilpeläinen
Ilkka
I
Heikkinen
Sami
S