title: Synthesis and biological evaluation of abietic acid derivatives.
abstract: A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at C18 did improve the resultant bioactivity, while the presence of an acid or alcohol led to less active compounds.
authors.affiliation: Departamento de Química Orgánica, Universidad de Valencia, Dr. Moliner 50, E-46100 Burjassot, Valencia, Spain. miguel.a.gonzalez@uv.es
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González
authors.forename: Julieth
authors.initials: J
authors.lastname: Correa-Royero
authors.forename: Lee
authors.initials: L
authors.lastname: Agudelo
authors.forename: Ana
authors.initials: A
authors.lastname: Mesa
authors.forename: Liliana
authors.initials: L
authors.lastname: Betancur-Galvis
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001232:Aspergillus fumigatus / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002522:Chlorocebus aethiops; D004305:Dose-Response Relationship, Drug; D015195:Drug Design; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014709:Vero Cells
chemical_list: D045784:Abietanes; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D000998:Antiviral Agents; C023710:abietic acid