[Prediction of the microRNAs related to cardiovascular diseases by bioinformatics].
OBJECTIVE
To predict the microRNAs (miRNAs) related to cardiovascular diseases.


METHODS
Bioinformatics was used to find all cardiovascular disease related and cardiovascular function related protein-coding genes, and miRNAs were identified that localized the same transcription units as the above genes. Then other cardiovascular disease related miRNAs were identified by an miRNAs set and family analysis and Gene Ontology(GO).


RESULTS
Twenty potential cardiovascular disease related miRNAs were predicted from 626 cardiovascular disease related miRNAs, five of which had been confirmed by experiments.


CONCLUSIONS
This study is of great help for the diagnosis and research of cardiovascular diseases, but the final conclusion need to be confirmed by experiments.
Zhang
Fan
F
Department of Geratology, Peking University Third Hospital, Beijing 100191, China.
Lu
Ming
M
Zhang
Qi-peng
QP
Zhang
Fu-chun
FC
Gao
Wei
W
Cui
Qing-hua
QH
D002318:Cardiovascular Diseases / Q000235:genetics*; D019295:Computational Biology / Q000379:methods*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000502:physiology
D035683:MicroRNAs