title: Wound healing delay after central venous access following DCF/VEGF-trap therapy.
abstract: Hypertension, proteinuria, thromboembolic or bleeding events are well-recognized complications occurring while targeting VEGF pathway. Wound healing dysfunctions have also been described in patients undergoing major surgery. For the first time, we report wound healing delay after central venous access following DCF-VEGF-Trap. VEGF-Trap may affect both angiogenesis and reepithelialization which are necessary to the normal repair process.
authors.affiliation: Department of Medicine, Institut Gustave Roussy, Phase I unit (SITEP), 94805, Villejuif, France. chferte@hotmail.com
authors.forename: Charles
authors.initials: C
authors.lastname: Ferté
authors.forename: Christophe
authors.initials: C
authors.lastname: Massard
authors.forename: Christian
authors.initials: C
authors.lastname: Moldovan
authors.forename: Eric
authors.initials: E
authors.lastname: Desruennes
authors.forename: Yohann
authors.initials: Y
authors.lastname: Loriot
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Soria
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D062905:Central Venous Catheters / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects*; D000077143:Docetaxel; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D008297:Male; D040262:Receptors, Vascular Endothelial Growth Factor / Q000009:adverse effects*; D011993:Recombinant Fusion Proteins / Q000009:adverse effects*; D043823:Taxoids / Q000009:adverse effects*; D014945:Wound Healing
chemical_list: D011993:Recombinant Fusion Proteins; D043823:Taxoids; C533178:aflibercept; D000077143:Docetaxel; D040262:Receptors, Vascular Endothelial Growth Factor; D002945:Cisplatin; D005472:Fluorouracil