MDM2 309 polymorphism is associated with missed abortion.
BACKGROUND
In this study, we assessed whether the single nucleotide polymorphism in the murine double minute 2 (MDM2) promoter (SNP309) was associated with the occurrence of missed abortion.


METHODS
Genotyping of MDM2 SNP309 polymorphism was conducted by polymerase chain reaction-restriction fragment length polymorphism with blood and villous samples from 95 women diagnosed as having 1st trimester missed abortion.


RESULTS
The MDM2 SNP309 G/G genotype was associated with a higher risk of missed abortion compared with the T/T+ T/G genotype in blood (P = 0.010; odds ratio (OR): 2.164; 95% confidence interval (CI): 1.207-3.878) and villous samples (P = 0.043; OR: 2.767; 95% CI: 1.092-7.011).


CONCLUSIONS
The MDM2 SNP309 G/G genotype may be a genetic risk factor for missed abortion.
Fang
Yan
Y
Department of Obstetrics and Gynecology, Qilu Hospital, Shandong University, 107 Wenhuaxi Road, Ji'nan 250012, Shandong, People's Republic of China.
Kong
Beihua
B
Yang
Qifeng
Q
Ma
Daoxin
D
Qu
Xun
X
D000030:Abortion, Missed / Q000453:epidemiology* / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2