Total synthesis of (-)-amphidinolide K.
Macrolide magic: An enyne cross-metathesis reaction of an alkynyl boronate with an alkene derivative as well as a radical cyclization reaction of a homopropargylic beta-alkoxyacrylate are the key transformations in the total synthesis of the cytotoxic macrolide (-)-amphidinolide K.
Ko
Haye Min
HM
Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
Lee
Chung Whan
CW
Kwon
Hyung Kyoo
HK
Chung
Hea Seung
HS
Choi
Soo Young
SY
Chung
Young Keun
YK
Lee
Eun
E
D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D000097442:Amphidinolides
D000475:Alkenes; D018942:Macrolides; C409107:amphidinolide K; D000097442:Amphidinolides