Primary pituitary lymphoma: a histological, immunohistochemical, and ultrastructural study with literature review.
We report the case of a 62-year-old man with headache and left sixth cranial nerve palsy. A computerized tomography scan revealed an osteolytic process involving the sella turcica and clivus. A partial tumor resection was achieved via an endoscopic transsphenoidal approach. Morphologic investigation revealed a diffuse large B cell lymphoma involving pituitary parenchyma. No systemic disease was found upon staging. Primary pituitary lymphoma is extremely rare. An accurate histologic diagnosis is key to successful treatment and a favorable prognosis. The literature is reviewed.
Moshkin
Olga
O
Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, M5B 1W8, Canada. olga_m99@hotmail.com
Muller
Paul
P
Scheithauer
Bernd W
BW
Juco
Jonathan
J
Horvath
Eva
E
Patterson
Bruce J
BJ
Kamel-Reid
Suzzane
S
Kovacs
Kalman
K
D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D014057:Tomography, X-Ray Computed