title: Intraindividual assessment of the thoracic aorta using contrast and non-contrast-enhanced MR angiography.
abstract: OBJECTIVE
  To avoid intravenous contrast media application, new MRA sequences using inherent blood contrast are available. The clinical use of these non-contrast-enhanced MRA (non-CE-MRA) sequences is still limited for the aorta. Thus, the goal was to compare a standard CE-MRA with a non-CE-MRA for the thoracic aorta.
  
  
  METHODS
  Ethics committee approval and informed consent were obtained. CE-MRA and non-CE-MRA (1.5 T) were performed in the same 50 healthy volunteers (mean age: 48). CE-MRA: GRE-Turbo-Flash-3D (1.2 x 1.2 x 1.6 mm (3)), 0.15 mmol Gd/kg, TA 22 +/- 2 sec. Non-CE-MRA: Respiratory-and cardiac-gated, T 2-prepared 3D-trueFISP (1.2 x 1.2 x 1.3 mm (3)), TA 14 +/- 5 min. Assessment included (3 readers, consensus): image quality (sharpness of vessel wall, signal homogeneity, artifacts) at the ascending aorta, arch, descending aorta and supra-aortic vessels.
  
  
  RESULTS
  The image quality in the ascending aorta was rated 'excellent' in 78 %, 'moderate' in 22 %, 'poor' in 0 % for non-CE-MRA versus 22 %, 50 %, and 28 % for CE-MRA (Cohen's kappa = 29 %, McNemar p < 0.001). In a comparison of non-CE-MRA versus CE-MRA, the aortic arch and descending aorta showed no significant difference (kappa = 58 %/p = 0.250 and kappa = 100 %/p = 1.000, respectively). Supra-aortic vessels were rated 'excellent' 45 %/ 49 %, 'moderate' 30 %/ 49 % and 'poor' 13 %/ 2 %, 12 % of supra-aortic vessels were visualized < 1 cm at non-CE-MRA.
  
  
  CONCLUSIONS
  Diagnostic image quality of the thoracic aorta can be achieved without application of intravenous contrast media. Images of the aortic root using ECG-gated non-CE-MRA are superior to standard CE-MRA. This technique might be applicable in NSF patients.
authors.affiliation: Radiologie, Deutsches Krebsforschungszentrum Heidelberg, Heidelberg, Germany. h.vonTengg@dkfz.de
authors.forename: H
authors.initials: H
authors.lastname: von Tengg-Kobligk
authors.forename: J
authors.initials: J
authors.lastname: Ley-Zaporozhan
authors.forename: V
authors.initials: V
authors.lastname: Henninger
authors.forename: K M
authors.initials: KM
authors.lastname: Grünberg
authors.forename: F L
authors.initials: FL
authors.lastname: Giesel
authors.forename: D
authors.initials: D
authors.lastname: Böckler
authors.forename: F
authors.initials: F
authors.lastname: Krummenauer
authors.forename: H-U
authors.initials: HU
authors.lastname: Kauczor
authors.forename: S
authors.initials: S
authors.lastname: Ley
mesh_terms: D000328:Adult; D000368:Aged; D001013:Aorta, Thoracic / Q000473:pathology*; D001027:Aortography / Q000379:methods*; D003287:Contrast Media; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007262:Infusions, Intravenous; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives; D008875:Middle Aged; D009942:Organometallic Compounds; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine