Expression of CDllc in blood monocytes as biomarker for favorable response to antituberculosis treatment.
CD11c is involved in Mycobacterium tuberculosis phagocytosis by human macrophages. CD11c has not been evaluated during antituberculosis (anti-TB) treatment. CD11c expression was evaluated on monocytes from peripheral blood leukocytes of pulmonary TB (PTB) patients and healthy controls by flow cytometry, whereas CD11c/Arg47Trp polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism. PTB patients had increased levels of CD11c on blood monocytes as compared to healthy controls. CD11c levels decreased in response to anti-TB treatment. CD11c/Arg47Trp polymorphism is not associated with PTB.
Rosas-Taraco
Adrian G
AG
Hospital Universitario, Monterrey, Nuevo León, Mexico.
Salinas-Carmona
Mario C
MC
Revol
Agnès
A
Rendon
Adrian
A
Caballero-Olin
Guillermo
G
Arce-Mendoza
Alma Y
AY
D000328:Adult; D000483:Alleles; D015415:Biomarkers / Q000032:analysis; D039521:CD11c Antigen / Q000032:analysis / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005838:Genotype; D006801:Humans; D008264:Macrophages / Q000378:metabolism* / Q000382:microbiology; D008297:Male; D009000:Monocytes / Q000378:metabolism* / Q000382:microbiology; D009169:Mycobacterium tuberculosis; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000235:genetics
D015415:Biomarkers; D039521:CD11c Antigen