title: Evaluation of the effect of treatment of latent tuberculosis infection on QuantiFERON-TB gold assay results.
abstract: To evaluate the utility of the QuantiFERON-TB Gold assay for monitoring latent tuberculosis treatment efficacy, the assay was performed serially for healthcare workers receiving isoniazid therapy. After 9 months of isoniazid therapy, all of these healthcare workers remained QuantiFERON-TB Gold positive, and cellular proliferation assays revealed persistently strong purified protein derivative responses. These results do not support the use of the QuantiFERON-TB Gold assay to monitor therapy.
authors.affiliation: Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, Massachusetts 12215, USA. npollock@bidmc.harvard.edu
authors.forename: Nira R
authors.initials: NR
authors.lastname: Pollock
authors.forename: Suely S
authors.initials: SS
authors.lastname: Kashino
authors.forename: Danielle R
authors.initials: DR
authors.lastname: Napolitano
authors.forename: Alex
authors.initials: A
authors.lastname: Sloutsky
authors.forename: Swati
authors.initials: S
authors.lastname: Joshi
authors.forename: Jasmine
authors.initials: J
authors.lastname: Guillet
authors.forename: Michael
authors.initials: M
authors.lastname: Wong
authors.forename: Edward
authors.initials: E
authors.lastname: Nardell
authors.forename: Antonio
authors.initials: A
authors.lastname: Campos-Neto
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007538:Isoniazid / Q000627:therapeutic use*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011933:Reagent Kits, Diagnostic; D012882:Skin Tests; D016896:Treatment Outcome; D014373:Tuberculin / Q000276:immunology; D014376:Tuberculosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D011933:Reagent Kits, Diagnostic; D014373:Tuberculin; D007371:Interferon-gamma; D007538:Isoniazid