title: Lipid profile and serum characteristics of the blind subterranean mole rat, Spalax.
abstract: BACKGROUND
  Spalax (blind subterranean mole rat), is a mammal adapted to live in fluctuating oxygen levels, and can survive severe hypoxia and hypercapnia. The adaptive evolution of Spalax to underground life resulted in structural and molecular-genetic differences comparing to above-ground mammals. These differences include higher myocardial maximal oxygen consumption, increased lung diffusion capacity, increased blood vessels density, and unique expression patterns of cancer and angiogenesis related genes such as heparanase, vascular endothelial growth factor, and P53.
  
  
  RESULTS
  Here we elucidate the main characteristics of Spalax lipid profile, as well as its main antioxidant and serum parameters. Compared to human, Spalax possesses lower total-cholesterol, low density lipoproteins (LDL) and triglycerides levels, and higher levels of high density lipoproteins (HDL). Apolipoprotein A-I and apolipoprotein B-100 were significantly lower in Spalax compared to human. Paraoxonase (PON) 1 arylesterase activity, was higher in Spalax compared to both human and mouse serum levels. Analysis of serum chemistry of Spalax revealed special features in this mammal.
  
  
  CONCLUSIONS
  Spalax possesses a unique lipid profile with high HDL and low LDL lipoproteins. The antioxidant serum content in the mole rat is higher than that of human and mouse. Serum C reactive protein (CRP) levels are significantly lower in Spalax compared to that of human or mouse, reflecting low levels of inflammation. These differences between Spalax, human and mouse are due to several factors including the intensive activity life-style that Spalax pursue underground, dietary components, and evolutionary genetic adaptations. Unfolding the genetic basis of these differences will probably result in unique treatments for a variety of human diseases such as dyslipedemias, inflammation and cancer.
authors.affiliation: Department of Oncology, Shaare Zedek Medical Center, Jerusalem, Israel. nicola.nasser@gmail.com
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Nasser
authors.forename: Marielle
authors.initials: M
authors.lastname: Kaplan
authors.forename: Eviatar
authors.initials: E
authors.lastname: Nevo
authors.forename: Michael
authors.initials: M
authors.lastname: Aviram
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis*; D043303:Aryldialkylphosphatase / Q000097:blood; D005075:Biological Evolution; D001769:Blood; D002097:C-Reactive Protein / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood*; D012641:Selection, Genetic; D046308:Spalax / Q000097:blood / Q000235:genetics
chemical_list: D000975:Antioxidants; D008055:Lipids; D002097:C-Reactive Protein; D043303:Aryldialkylphosphatase