title: Total synthesis of (-)-lycorine and (-)-2-epi-lycorine by asymmetric conjugate addition cascade.
abstract: Total syntheses of (-)-lycorine and (-)-2-epi-lycorine were accomplished using chiral ligand-controlled asymmetric cascade conjugate addition methodology, which enables the formation of two C-C bonds and three stereogenic centers in one pot to give synthetically useful chiral cyclohexane derivatives.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Yamada
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Yamashita
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sumiyoshi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Nishimura
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Tomioka
mesh_terms: D047151:Amaryllidaceae Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D047151:Amaryllidaceae Alkaloids; D010617:Phenanthridines; C015330:lycorine