title: Feasibility investigation of allogeneic endometrial regenerative cells.
abstract: Endometrial Regenerative Cells (ERC) are a population of mesenchymal-like stem cells having pluripotent differentiation activity and ability to induce neoangiogenesis. In vitro and animal studies suggest ERC are immune privileged and in certain situations actively suppress ongoing immune responses. In this paper we describe the production of clinical grade ERC and initial safety experiences in 4 patients with multiple sclerosis treated intravenously and intrathecally. The case with the longest follow up, of more than one year, revealed no immunological reactions or treatment associated adverse effects. These preliminary data suggest feasibility of clinical ERC administration and support further studies with this novel stem cell type.
authors.affiliation: Medistem Inc, San Diego, USA. jzhonguro@gmail.com
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Zhong
authors.forename: Amit N
authors.initials: AN
authors.lastname: Patel
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Ichim
authors.forename: Neil H
authors.initials: NH
authors.lastname: Riordan
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Min
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Woods
authors.forename: Michael
authors.initials: M
authors.lastname: Reid
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mansilla
authors.forename: Gustavo H
authors.initials: GH
authors.lastname: Marin
authors.forename: Hugo
authors.initials: H
authors.lastname: Drago
authors.forename: Michael P
authors.initials: MP
authors.lastname: Murphy
authors.forename: Boris
authors.initials: B
authors.lastname: Minev
mesh_terms: D000328:Adult; D004717:Endometrium / Q000166:cytology* / Q000473:pathology*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology / Q000601:surgery*; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000637:transplantation*; D012038:Regeneration; D014184:Transplantation, Homologous