title: Intermittent calorie restriction delays prostate tumor detection and increases survival time in TRAMP mice.
abstract: Prostate cancer is the most frequently diagnosed cancer in men. Whereas chronic calorie restriction (CCR) delays prostate tumorigenesis in some rodent models, the impact of intermittent caloric restriction (ICR) has not been determined. Here, transgenic adenocarcinoma of the mouse prostate (TRAMP) mice were used to compare how ICR and CCR affected prostate cancer development. TRAMP mice were assigned to ad libitum (AL), ICR (2 wk 50% AL consumption followed by 2 wk pair feeding to AL consumption), and CCR (25% AL consumption) groups at 7 wk of age and followed until disease burden necessitated euthanasia or mice reached terminal endpoints (48 or 50 wk of age). Body weights fluctuated in response to calorie intake (P < 0.0001). ICR mice were older at tumor detection than AL (P = 0.0066) and CCR (P = 0.0416) mice. There was no difference for age of tumor detection between AL and CCR mice (P = 0.3960). Similar results were found for survival. Serum leptin, adiponectin, insulin, and IGF-I were all significantly different among the groups. These results indicate that the way in which calories are restricted impacts both time to tumor detection and survival in TRAMP mice, with ICR providing greater protective effect compared to CCR.
authors.affiliation: Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA.
authors.forename: Melissa J L
authors.initials: MJ
authors.lastname: Bonorden
authors.forename: Olga P
authors.initials: OP
authors.lastname: Rogozina
authors.forename: Christina M
authors.initials: CM
authors.lastname: Kluczny
authors.forename: Michael E
authors.initials: ME
authors.lastname: Grossmann
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Grambsch
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Grande
authors.forename: Susan
authors.initials: S
authors.lastname: Perkins
authors.forename: Anna
authors.initials: A
authors.lastname: Lokshin
authors.forename: Margot P
authors.initials: MP
authors.lastname: Cleary
mesh_terms: D052242:Adiponectin / Q000097:blood; D000375:Aging; D000818:Animals; D001823:Body Composition; D031204:Caloric Restriction; D004032:Diet; D005838:Genotype; D007328:Insulin / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D020738:Leptin / Q000097:blood; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009362:Neoplasm Metastasis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate; D013997:Time Factors
chemical_list: D052242:Adiponectin; D007328:Insulin; D020738:Leptin; D007334:Insulin-Like Growth Factor I