Singlet oxygen generation using a porous monolithic polymer supported photosensitizer: potential application to the photodynamic destruction of melanoma cells.
Photogeneration of singlet oxygen (1O2) by rose bengal is improved through the use of a porous monolithic polymer (PMP) as a support, as compared to a classic gel-type resin matrix. This type of monolithic polymeric matrix can be made at a multigram scale in quantitative yields enabling the preparation of large amounts of supported photosensitizer at low cost. The singlet oxygen induced oxidation of 9,10-diphenylanthracene has been used as a benchmark reaction, and a comparative study using rose bengal in solution, entrapped within gel-type derived polymer and entrapped within a porous monolithic polymer (PMP) has been performed. The enhanced photoreactivity of the PMP-rose bengal conjugates has been utilised for the successful photodynamic therapy (PDT) of melanoma cells.
Burguete
M Isabel
MI
Departamento de Química Inorgánica y Orgánica/UAMOA, Universitat Jaume I/CSIC, Av. Sos Baynat, s/n, 12071, Castellón, Spain.
Galindo
Francisco
F
Gavara
Raquel
R
Luis
Santiago V
SV
Moreno
Miguel
M
Thomas
Paul
P
Russell
David A
DA
D000818:Animals; D045744:Cell Line, Tumor; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D018613:Microscopy, Confocal; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology; D026082:Singlet Oxygen / Q000737:chemistry*
D017319:Photosensitizing Agents; D026082:Singlet Oxygen