A randomized trial of a lifestyle intervention in obese endometrial cancer survivors: quality of life outcomes and mediators of behavior change.
BACKGROUND
To examine the effects of a 6 month lifestyle intervention on quality of life, depression, self-efficacy and eating behavior changes in overweight and obese endometrial cancer survivors.


METHODS
Early stage endometrial cancer survivors were randomized to intervention (n = 23) or usual care (n = 22) groups. Chi-square, Student's t-test and repeated measures analysis of variance were used in intent-to-treat analyses. Outcomes were also examined according to weight loss.


RESULTS
Morbidly obese patients had significantly lower self-efficacy, specifically when feeling physical discomfort. There was a significant improvement for self-efficacy related to social pressure (p = .03) and restraint (p = .02) in the LI group. There was a significant difference for emotional well-being quality of life (p = .02), self-efficacy related to negative emotions (p < .01), food availability (p = .03), and physical discomfort (p = .01) in women who lost weight as compared to women who gained weight. Improvement in restraint was also reported in women who lost weight (p < .01).


CONCLUSIONS
This pilot lifestyle intervention had no effect on quality of life or depression but did improve self-efficacy and some eating behaviors.


BACKGROUND
http://www.clinicaltrials.gov; NCT00420979.
von Gruenigen
Vivian E
VE
University Hospitals Case Medical Center, Cleveland, OH, USA. vivian.vongruenigen@UHhospitals.org
Gibbons
Heidi E
HE
Kavanagh
Mary Beth
MB
Janata
Jeffrey W
JW
Lerner
Edith
E
Courneya
Kerry S
KS
D003863:Depression / Q000150:complications; D016889:Endometrial Neoplasms / Q000150:complications* / Q000523:psychology; D005247:Feeding Behavior; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000523:psychology / Q000628:therapy*; D010865:Pilot Projects; D011788:Quality of Life / Q000523:psychology; D040242:Risk Reduction Behavior; D020377:Self Efficacy; D015430:Weight Gain; D015431:Weight Loss