title: Health-related quality of life in methadone maintenance patients with untreated hepatitis C virus infection.
abstract: OBJECTIVE
  To assess health-related quality of life (HRQOL) in methadone maintenance treatment (MMT) patients with untreated chronic HCV infection and to determine the clinical factors that predict HRQOL.
  
  
  METHODS
  HRQOL was measured in 100 MMT patients entering an HCV treatment trial. Subjects were mostly male (61%) and white (81%) with a mean age of 43 (+/-10). 57% had a current non-substance use psychiatric disorder. 55% had a current (past 12 months) substance use disorder, including 44% with current opioid or cocaine abuse/dependence. HRQOL in our sample was compared to published reports for the general population as well as for non-MMT HCV patients. To assess predictors of SF-36 HRQOL, hierarchical multiple regression techniques were used to assess model improvement with four blocks of baseline predictors: Demographics, Medical Severity, Addiction Severity, and Depression Severity.
  
  
  RESULTS
  HRQOL scores were significantly lower than scores for the general population and were also lower than scores reported for untreated HCV patients not in MMT. Regression analysis demonstrated a consistent pattern whereby Depression Severity increased predictive accuracy for HRQOL measures over simpler models. Beck Depression Inventory scores significantly predicted quality of life across both the mental and physical composite scores and all eight sub-scales of the SF-36.
  
  
  CONCLUSIONS
  Untreated HCV patients in MMT had lower HRQOL than HCV patients not in MMT. Depression Severity was associated with significantly lower quality of life measures, suggesting that psychiatric evaluation and intervention prior to the start of HCV treatment may improve overall quality of life and could influence HCV treatment outcomes in MMT patients.
authors.affiliation: University of California, San Francisco, Department of Psychiatry, and San Francisco VA Medical Center, 4150 Clement St. (116P), San Francisco, CA 94110, USA. steven.batki@ucsf.edu
authors.forename: Steven L
authors.initials: SL
authors.lastname: Batki
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Canfield
authors.forename: Emily
authors.initials: E
authors.lastname: Smyth
authors.forename: Robert
authors.initials: R
authors.lastname: Ploutz-Snyder
mesh_terms: D000328:Adult; D003863:Depression / Q000453:epidemiology; D005006:Ethnicity; D006304:Health Status; D006526:Hepatitis C / Q000150:complications* / Q000523:psychology; D006801:Humans; D008603:Mental Health; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D044469:Racial Groups; D011897:Random Allocation; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications / Q000523:psychology / Q000534:rehabilitation*; D011795:Surveys and Questionnaires; D019562:Viral Load
chemical_list: D008691:Methadone