title: pH-dependent Fe (II) pathophysiology and protective effect of an organoselenium compound.
abstract: Influence of pH on the extent of lipid peroxidation and the anti-oxidant potential of an organoselenium compound is explored. Acidosis increased the rate of lipid peroxidation both in the absence and presence of Fe (II) in rat's brain, kidney and liver homogenate and phospholipids extract from egg yolk. The organoselenium compound significantly protected lipids from peroxidation, both in the absence and presence of Fe (II). Changing the pH of the reaction medium did not alter the anti-oxidant activity of the tested compound. This study provides in vitro evidence for acidosis-induced oxidative stress in brain, kidney, liver homogenate and phospholipids extract and the anti-oxidant action of the tested organoselenium compound.
authors.affiliation: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP 97105-900, RS, Brazil. waseem_anw@yahoo.com
authors.forename: Waseem
authors.initials: W
authors.lastname: Hassan
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ibrahim
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Deobald
authors.forename: Antonio Luiz
authors.initials: AL
authors.lastname: Braga
authors.forename: Cristina Wayne
authors.initials: CW
authors.lastname: Nogueira
authors.forename: Joao B T
authors.initials: JB
authors.lastname: Rocha
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D019610:Cytoprotection / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005296:Ferrous Compounds / Q000009:adverse effects* / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007097:Imines / Q000494:pharmacology; D019189:Iron Metabolism Disorders / Q000209:etiology* / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008954:Models, Biological; D016566:Organoselenium Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: C539691:2-((1-(2-(2-(2-(1-(2-hydroxybenzylideneamino)ethyl)phenyl)diselanyl)phenyl)ethylimino)methyl)phenol; D000975:Antioxidants; D005296:Ferrous Compounds; D007097:Imines; D016566:Organoselenium Compounds; D010743:Phospholipids; D017392:Thiobarbituric Acid Reactive Substances; D008315:Malondialdehyde