title: Decreased plasma levels of soluble receptor for advanced glycation endproducts (sRAGE) in patients with nonalcoholic fatty liver disease.
abstract: OBJECTIVE
  Levels of soluble receptor for advanced glycation endproducts (sRAGE) have been linked to several components of the metabolic syndrome. We tested the hypothesis that plasma levels of sRAGE may be associated with non-alcoholic fatty liver disease.
  
  
  METHODS
  We enrolled subjects with definite nonalcoholic steatohepatitis (NASH, n=40), borderline NASH (n=8), simple fatty liver (n=9) and healthy controls (n=14). Plasma levels of sRAGE were measured by ELISA.
  
  
  RESULTS
  Concentrations of sRAGE were significantly lower in patients with definite NASH (1080+/-392 pg/mL, P<0.01) and borderline NASH (1050+/-278 pg/mL, P<0.05) compared to controls (1480+/-387 pg/mL). Levels of sRAGE were significantly and inversely correlated with ALT (r=-0.30, P<0.05) and AST (r=-0.23, P<0.05).
  
  
  CONCLUSIONS
  Plasma levels of sRAGE are significantly reduced in definite and borderline NASH.
authors.affiliation: Department of Gastroenterology, Marmara University, School of Medicine, 34662, Altunizade, Istanbul, Turkey. yusufyilmaz@uludag.edu.tr
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yilmaz
authors.forename: Engin
authors.initials: E
authors.lastname: Ulukaya
authors.forename: Ozen Oz
authors.initials: OO
authors.lastname: Gul
authors.forename: Mahmut
authors.initials: M
authors.lastname: Arabul
authors.forename: Cuma Bulent
authors.initials: CB
authors.lastname: Gul
authors.forename: Ozlen
authors.initials: O
authors.lastname: Atug
authors.forename: Arzu Yilmaztepe
authors.initials: AY
authors.lastname: Oral
authors.forename: Sibel
authors.initials: S
authors.lastname: Aker
authors.forename: Enver
authors.initials: E
authors.lastname: Dolar
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005234:Fatty Liver / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic