title: A case of nephrogenic diabetes insipidus caused by partial bilateral ureteral obstruction due to advanced stage ovarian carcinoma.
abstract: Nephrogenic diabetes insipidus (NDI) secondary to chronic urinary tract obstruction is a rare condition. The exact cause is unknown; it is likely that increased collecting duct pressures cause damage to the tubular epithelium, resulting in insensitivity to the antidiuretic hormone (ADH). We report a case of NDI associated with ureteral obstruction caused by advanced stage ovarian carcioma in a 20-year-old girl. After debulcking surgery, massive polyuria continued. Several administrations of an ADH analog were ineffective in reducing urine output, suggesting a possible relationship of massive polyuria with NDI. Following oral administration of a thiazide diuretic, known to exert antidiuretic action in NDI, the urine output was dramatically reduced. This case suggests that ureteral obstruction due to ovarian mass may cause NDI and after the surgery thiazide diuretics are effective in reducing urine output in NDI with ureteral obstruction.
authors.affiliation: Dr. Zekai Tahir Burak Woman's Health Education and Research Hospital, Ankara, Turkey.
authors.forename: Tayfun
authors.initials: T
authors.lastname: Gungor
authors.forename: Mahmut Kuntay
authors.initials: MK
authors.lastname: Kokanalý
authors.forename: Demet
authors.initials: D
authors.lastname: Oztürkkan
authors.forename: Omer L
authors.initials: OL
authors.lastname: Tapisiz
authors.forename: Leyla
authors.initials: L
authors.lastname: Mollamahmutoglu
mesh_terms: D002277:Carcinoma / Q000150:complications*; D018500:Diabetes Insipidus, Nephrogenic / Q000209:etiology*; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications*; D014517:Ureteral Obstruction / Q000150:complications*; D055815:Young Adult