Neuropilins, semaphorins, and their role in thymocyte development.
Some molecules described in the nervous system are also expressed in cells involved in the control of the immune response, suggesting they have a role as common mechanisms between neuroendocrine and immune systems. In this review, we focus on the expression and role of neuropilins (NPs) and their soluble ligands class 3 semaphorins in thymus physiology, particularly migration of developing thymocytes. We also discuss the concept of multivectorial thymocyte migration, including semaphorins, as a new individual cell migration vector.
Mendes-da-Cruz
Daniella Arêas
DA
Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. daniella@ioc.fiocruz.br
Lepelletier
Yves
Y
Brignier
Anne C
AC
Smaniotto
Salete
S
Renand
Amédée
A
Milpied
Pierre
P
Dardenne
Mireille
M
Hermine
Olivier
O
Savino
Wilson
W
D000818:Animals; D002465:Cell Movement; D006801:Humans; D009420:Nervous System / Q000378:metabolism; D039921:Neuropilins / Q000378:metabolism*; D039961:Semaphorins / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology* / Q000378:metabolism* / Q000473:pathology
D039921:Neuropilins; D039961:Semaphorins