No genetic association between polymorphisms of heme oxygenase 1 and 2 and Alzheimer's disease in a Japanese population.
OBJECTIVE
Recently, it has been shown that the heme oxygenases HMOX1 and HMOX2 might play a role in the pathogenesis of Alzheimer's disease (AD).


METHODS
To investigate whether there is any association between the HMOX1 and HMOX2 genes and AD, five single nucleotide polymorphisms (SNPs) in each gene were genotyped in 180 AD patients and 132 age-matched controls using TaqMan technology.


RESULTS
Our study failed to detect any association between the SNPs of the HMOX1 and HMOX2 genes and AD. In addition, we did not observe any synergetic association between the SNPs studied and apolipoprotein E in our AD patients.


CONCLUSIONS
Further genetic studies are needed to clarify the relationship between the two genes and AD.
Shibata
Nobuto
N
Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan. nobuto.shibata@nifty.ne.jp
Ohnuma
Tohru
T
Baba
Hajime
H
Arai
Heii
H
D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology* / Q000235:genetics*; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006419:Heme Oxygenase (Decyclizing) / Q000235:genetics*; D051547:Heme Oxygenase-1 / Q000235:genetics*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
D004247:DNA; D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C105245:heme oxygenase-2