[Effect of reduced glutathione on impairment of hepatic function after delayed resuscitation of severe burn shock].
OBJECTIVE
To investigate the protective effects of the reduced glutathione (GSH) on hepatic injury after delayed resuscitation in patients with severe burn.


METHODS
Forty severely burned patients with hepatic injury after delayed resuscitation were randomly divided into two groups: treatment group (T, 20 cases) and control group (C, 20 cases). In the T group, the patients were treated with GSH for 7-14 days, while the patients in the C group were treated with same quantity of "energy mixture" as control. The venous blood sample of each patient of the two groups was collected and examined for the content of alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyltranspeptidase (gamma-GT), alkaline phosphatase (ALP), total bilirubin (TBIL), and direct bilirubin (DBIL) before the treatment and 7 days and 14 days after the treatment.


RESULTS
The contents of the enzymes in the T group were significantly decreasing gradually in all patients after 7 days and 14 days of treatment (P<0.05 or P<0.01). In the C group, the enzymes showed a decrease in quantity 7 days after the management but without statistical significance. However, they still showed significant decrease on 14th day with the "energy mixture" treatment (all P<0.05). After 14 days of the treatment, ALT, AST, gamma-GT, TBIL and DBIL showed obvious decrease in the T group compared to the C group (all P<0.05), but there was no significant difference in ALP between the two groups.


CONCLUSIONS
The results of this study indicates that early use of GSH may be beneficial in the management of protecting hepatic injury after delayed resuscitation for severe burn.
Huang
Yong-xin
YX
Department of Burn and Plastic Surgery, 95th Clinical Department of General Hospital of Fuzhou Command of PLA, Putian 351100, Fujian, China. huangyongxin2008@126.com
Zhan
Xin-hua
XH
Liu
Shi-kang
SK
Zhu
Jian-xian
JX
Chen
Jian-chong
JC
Wu
Zu-huang
ZH
Xie
Bao-gen
BG
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D002056:Burns / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005978:Glutathione / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012151:Resuscitation; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood
D005723:gamma-Glutamyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione