title: Effect on diurnal intraocular pressure of the fixed combination of latanoprost 0.005% and timolol 0.5% administered in the evening in glaucoma.
abstract: We evaluated the efficacy of fixed combination of 0.005% latanoprost and 0.5% timolol maleate administered once daily in the evening for treating glaucoma patients. This combination proved an effective alternative to achieve an additional intraocular pressure IOP lowering effect in patients treated with either drug alone and as an alterative in patients treated with unfixed combination of latanoprost and timolol and optimal IOP control.
authors.affiliation: Department of Ophthalmology, Isabel la Católica 1-3, 50.009 Zaragoza, Spain. vicpolo@telefonica.net
authors.forename: Vicente
authors.initials: V
authors.lastname: Polo
authors.forename: José M
authors.initials: JM
authors.lastname: Larrosa
authors.forename: Antonio
authors.initials: A
authors.lastname: Ferreras
authors.forename: Enrique
authors.initials: E
authors.lastname: Borque
authors.forename: Luis E
authors.initials: LE
authors.lastname: Pablo
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Honrubia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002940:Circadian Rhythm / Q000187:drug effects*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D017889:Exfoliation Syndrome / Q000188:drug therapy; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D013999:Timolol / Q000008:administration & dosage*; D014065:Tonometry, Ocular; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004338:Drug Combinations; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D013999:Timolol