title: Psychotic disorder and focal epilepsy in a left-handed patient with chromosome XYY abnormality.
abstract: OBJECTIVE
  To discuss the relationship between XYY chromosome abnormality, psychiatric disorders and epilepsy.
  
  
  METHODS
  Single case report.
  
  
  RESULTS
  A 34-year-old man with 47, XYY karyotype and normal intelligence was followed-up at a neuropsychiatric clinic for over 30 years. He was first seen at age 3 years with a history of delayed motor and language development and an immunodeficiency syndrome. At age 8 years he developed refractory focal epilepsy, and in late adolescence he started to exhibit increasingly prominent obsessive thoughts, paranoid ideation, and aggressive sexual fantasies and behaviour.
  
  
  CONCLUSIONS
  When interpreted within the context of previous literature reports, this case suggests a pathophysiological link between XYY chromosome abnormality, characteristic psychiatric symptoms and epilepsy disorder.
authors.affiliation: Department of Behavioural Neurology and Laboratory of Cognitive Behavioural Psychology, Fondazione "Istituto Neurologico Casimiro Mondino", Pavia, Italy. annapia.verri@mondino.it
authors.forename: A P
authors.initials: AP
authors.lastname: Verri
authors.forename: C A
authors.initials: CA
authors.lastname: Galimberti
authors.forename: P
authors.initials: P
authors.lastname: Perucca
authors.forename: A
authors.initials: A
authors.lastname: Cremante
authors.forename: M
authors.initials: M
authors.lastname: Vernice
authors.forename: A
authors.initials: A
authors.lastname: Uggetti
mesh_terms: D000328:Adult; D000374:Aggression / Q000502:physiology / Q000523:psychology; D002531:Cerebellum / Q000002:abnormalities / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000235:genetics / Q000502:physiology; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000235:genetics* / Q000503:physiopathology; D020938:Epilepsy, Partial, Motor / Q000175:diagnosis / Q000503:physiopathology; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology; D007839:Functional Laterality / Q000235:genetics* / Q000502:physiology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000503:physiopathology; D007360:Intelligence / Q000235:genetics / Q000502:physiology; D007805:Language Development Disorders / Q000235:genetics / Q000503:physiopathology; D020547:Lateral Ventricles / Q000002:abnormalities / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D010259:Paranoid Disorders / Q000235:genetics* / Q000503:physiopathology; D010641:Phenotype; D013702:Temporal Lobe / Q000503:physiopathology; D014997:XYY Karyotype / Q000235:genetics* / Q000503:physiopathology