Nanoparticles containing anti-inflammatory agents as chemotherapy adjuvants II: role of plasma esterases in drug release.
Lu
Xiuling
X
Division of Molecular Pharmaceutics, University of North Carolina, Chapel Hill, North Carolina 27599-3560, USA.
Howard
Melissa D
MD
Talbert
Dominique R
DR
Rinehart
John J
JJ
Potter
Philip M
PM
Jay
Michael
M
Leggas
Markos
M
D000277:Adjuvants, Pharmaceutic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001711:Biotransformation; D043182:Carboxylesterase / Q000097:blood / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D003470:Culture Media; D003907:Dexamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D004950:Esterases / Q000097:blood / Q000502:physiology*; D004952:Esters / Q000097:blood / Q000493:pharmacokinetics; D006801:Humans; D006868:Hydrolysis; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008819:Mice, Nude; D053758:Nanoparticles / Q000008:administration & dosage*; D009895:Opsonin Proteins / Q000378:metabolism; D010949:Plasma; D011355:Prodrugs / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution; D023041:Xenograft Model Antitumor Assays
D000277:Adjuvants, Pharmaceutic; D000893:Anti-Inflammatory Agents; D003470:Culture Media; D004952:Esters; D009895:Opsonin Proteins; D011355:Prodrugs; D003907:Dexamethasone; D004950:Esterases; D043182:Carboxylesterase