Instructing B cell fates on the fringe.
The Notch2 ligand DL1 is required for marginal zone B cell development. In this issue of Immunity, Tan et al. (2009) show that modification of Notch2 by Fringe enzymes is critical to maturing B cells for accessing DL1 on vascular endothelial cells.
Allman
David
D
Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, USA.
Calamito
Marco
M
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage / Q000276:immunology*; D016695:Glycosyltransferases / Q000172:deficiency / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D051379:Mice
D016695:Glycosyltransferases; C498392:Lfng protein, mouse