title: [Plasmacytoid dendritic cells in pathophysiology of immune responses].
abstract: Plasmacytoid dendritic cells (pDC), so named because of histological similarities to antibody-producing plasma cells, comprise a unique dendritic cell population. Despite their low numbers in blood they play a key role in anti-viral immunity, mainly through secreting massive amounts of type 1 interferon following an engagement of their Toll-like receptors, such as TLR7 and TLR9, by viral nucleic acids. In a mature state, pDC display a propensity to present antigens to naive lymphocytes. Through their unique potential to rapidly and efficiently secrete type I interferon and serve as antigen presenting cells, pDC are currently considered as one of the major regulators of immune responses.
authors.affiliation: Zakład Immunologii, Wydział Biochemii, Biofizyki i Biotechnologii Uniwersytetu Jagiellońskiego, Kraków.
authors.forename: Paulina
authors.initials: P
authors.lastname: Kulig
authors.forename: Karolina
authors.initials: K
authors.lastname: Wawro
authors.forename: Joanna
authors.initials: J
authors.lastname: Cichy
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007370:Interferon Type I / Q000378:metabolism*; D008214:Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D016207:Cytokines; D007370:Interferon Type I; D051193:Toll-Like Receptors