ERK2 dependent signaling contributes to wound healing after a partial-thickness burn.
Burn healing is a complex physiological process involving multiple cell activities, such as cell proliferation, migration and differentiation. Although extracellular signal-regulated kinases (ERK) have a pivotal role in regulating a variety of cellular responses, little is known about the individual functions of ERK isoform for healing in vivo. This study investigated the role of ERK2 in burn healing. To assess this, Erk2(+/-) mice generated by gene targeting were used. The resultant mice exhibited significant delay in re-epithelization of partial-thickness burns in the skin in comparison to wild-type. An in vitro proliferation assay revealed that keratinocytes from Erk2(+/-) mice grew significantly slower than those prepared from wild-type. These results highlight the importance of ERK2 in the process of burn healing.
Satoh
Yasushi
Y
Department of Biochemistry, National Defense Medical College, 3-2 Namiki, Tokorozawa 359-8513, Japan. ys@ndmc.ac.jp
Saitoh
Daizoh
D
Takeuchi
Atsuya
A
Ojima
Kenichiro
K
Kouzu
Keita
K
Kawakami
Saki
S
Ito
Masataka
M
Ishihara
Masayuki
M
Sato
Shunichi
S
Takishima
Kunio
K
D000818:Animals; D002056:Burns / Q000201:enzymology* / Q000473:pathology; D049109:Cell Proliferation; D004195:Disease Models, Animal; D015603:Keratinocytes / Q000201:enzymology / Q000473:pathology; D051379:Mice; D008817:Mice, Mutant Strains; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000502:physiology*; D010766:Phosphorylation; D015398:Signal Transduction; D012867:Skin / Q000201:enzymology* / Q000473:pathology; D014945:Wound Healing
D019950:Mitogen-Activated Protein Kinase 1