[Lymphocytic-thrombocytic adhesion and production of blood serum cytokines in rheumatic heart disease].
OBJECTIVE
To study changes of cytokine production and lymphocytic-thrombocytic adhesion (LTA) in patients with rheumatic heart disease.


METHODS
Concentrations of interleukine-1beta, interleukine-4, tumor necrosis factor alpha in the blood serum and lymphocytic-thrombocytic adhesion by Yu. A. Vitkovsky's method were measured in 84 patients with rheumatic fever and 26 healthy ones.


RESULTS
A correlation was found between increased production of inflammatory cytokines, lymphocytic-thrombocytic adhesion and activation of rheumatic process.


CONCLUSIONS
A monodirection of changes of inflammatory cytokine production, lymphocytic-thrombocytic adhesion and rheumatic fever activation allows using them as nonspecific diagnostic methods in assessment of inflammation activity.
Gorbunov
V V
VV
Tsarenok
S Iu
SIu
Rosin
I V
IV
D000328:Adult; D001792:Blood Platelets / Q000166:cytology* / Q000276:immunology; D016022:Case-Control Studies; D002448:Cell Adhesion / Q000276:immunology; D016207:Cytokines / Q000097:blood*; D003627:Data Interpretation, Statistical; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012214:Rheumatic Heart Disease / Q000097:blood* / Q000276:immunology; D055815:Young Adult
D016207:Cytokines