Recent mechanistic insights into eukaryotic ribosomes.
Ribosomes are supramolecular ribonucleoprotein particles that synthesize proteins in all cells. Protein synthesis proceeds through four major phases: initiation, elongation, termination, and ribosome recycling. In each phase, a number of phase-specific translation factors cooperate with the ribosome. Whereas elongation in prokaryotes and eukaryotes involve similar factors and proceed by similar mechanisms, mechanisms of initiation, termination, and ribosome recycling, as well as the factors involved, appear quite different. Here, we summarize recent progress in deciphering molecular mechanisms of eukaryotic translation. Comparisons with prokaryotic translation are included, emphasizing emerging patterns of common design.
Rodnina
Marina V
MV
Max-Planck-Institute for Biophysical Chemistry, Department of Physical Biochemistry, 37077 Göttingen, Germany. Rodnina@mpibpc.mpg.de
Wintermeyer
Wolfgang
W
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D010442:Peptide Chain Initiation, Translational / Q000235:genetics; D010443:Peptide Chain Termination, Translational / Q000235:genetics; D010454:Peptide Termination Factors / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000378:metabolism*
D010454:Peptide Termination Factors