title: Microbial transformation of dehydroandrographolide by Cunninghamella elegans.
abstract: The biotransformation of dehydroandrographolide (1) by Cunninghamella elegans was performed and four transformed products were obtained. Based on their extensive spectral data, the structures of these metabolites were identified as 3-oxo-dehydroandrographolide (2), 3-oxo-2beta-hydroxy-dehydroandrographolide (3), 3-oxo-8beta,17alpha-epoxydehydroandrographolide (4), 3,19-dihydroxy-7,11,13-ent-labdatrien-15,16-olide (5), respectively. Among them, products 3-5 are new compounds.
authors.affiliation: Key Laboratory of Bioprocess of Beijing, Beijing University of Chemical Technology, Beijing, China.
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Xin
authors.forename: Xiao-Chi
authors.initials: XC
authors.lastname: Ma
authors.forename: Bao-Jing
authors.initials: BJ
authors.lastname: Zhang
authors.forename: Dong-Hai
authors.initials: DH
authors.lastname: Su
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Wu
authors.forename: Xiao-Jie
authors.initials: XJ
authors.lastname: Wang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Li
authors.forename: Qi-Peng
authors.initials: QP
authors.lastname: Yuan
mesh_terms: D000818:Animals; D001711:Biotransformation; D017173:Caenorhabditis elegans / Q000378:metabolism; D020093:Cunninghamella / Q000378:metabolism*; D004224:Diterpenes / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000378:metabolism; D012233:Rhizopus / Q000378:metabolism
chemical_list: D004224:Diterpenes; C478098:dehydroandrographolide