Heme-oxygenase-2 immunolabelling in pig jejunum.
Heme-oxygenase-2 generates carbon monoxide in the enteric nervous system and in interstitial cells of Cajal in the canine, mouse and human jejunum. Carbon monoxide is considered a non-adrenergic and non-cholinergic inhibitory neurotransmitter and it establishes and maintains the resting membrane potential in the stomach and small intestine. The aim of this study was to determine the distribution of heme-oxygenase-2 in the enteric nervous system of the pig jejunum. Heme-oxygenase-2 immunoreactivity was found in neurons of myenteric ganglia and in nerve fibers in the circular and longitudinal muscle layers. These results suggest that carbon monoxide is produced in the enteric nervous system of the pig jejunum and might mediate inhibitory neural activity in myenteric ganglia and inhibitory neural input to smooth muscle cells in the circular and longitudinal muscle layers.
Matsuda
Nilce Mitiko
NM
Departamento de Cirurgia e Anatomia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, 14049-900 Ribeirão Preto, SP, Brazil. nmmatsuda@uol.com.br
Miller
Steven M
SM
Szurszewski
Joseph H
JH
D000818:Animals; D017615:Enteric Nervous System / Q000378:metabolism; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D013552:Swine
D006419:Heme Oxygenase (Decyclizing); C105245:heme oxygenase-2