title: Synthesis of 2,4-disubstituted pyrroles by rearrangements of 2-furanyl carbamates.
abstract: 2,4-Disubstituted pyrroles were synthesized by an oxidative rearrangement of a furanyl carbamate followed by sequential reaction of the resulting 5-methoxypyrrol-2(5H)-one with different alkyl lithiates. The final step of the procedure involves heating the ring opened 1-methoxy-5-oxopentylcarbamate with a primary amine.
authors.affiliation: Department of Chemistry, Emory University, Atlanta, Georgia, 30322, USA.
authors.forename: Sezgin
authors.initials: S
authors.lastname: Kiren
authors.forename: Xuechuan
authors.initials: X
authors.lastname: Hong
authors.forename: Carolyn A
authors.initials: CA
authors.lastname: Leverett
authors.forename: Albert
authors.initials: A
authors.lastname: Padwa
mesh_terms: D002219:Carbamates / Q000737:chemistry*; D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002219:Carbamates; D005663:Furans; D011758:Pyrroles