title: Bilateral uveitis secondary to bisphosphonate therapy.
abstract: OBJECTIVE
  To highlight the potential ocular side effects of bisphosphonate therapy and the importance of a proper drug history in patients who present with uveitis.
  
  
  METHODS
  We report 2 cases of bilateral uveitis secondary to bisphosphonate therapy. Both patients were on nitrogen-containing bisphosphonates when they developed symptoms of bilateral anterior uveitis. A uveitis screen done in both cases was normal.
  
  
  RESULTS
  The uveitis in both patients resolved after discontinuation of the bisphosphonates, and there has been no recurrence of symptoms during the duration of the follow-up of 6 and 5 months, respectively.
  
  
  CONCLUSIONS
  All patients receiving bisphosphonates who develop ocular signs and symptoms should be referred promptly to an ophthalmologist. The offending drug should be discontinued once the diagnosis is made, in order to prevent involvement of the contralateral eye and recurrent or chronic ocular inflammation. Patients who are susceptible to the nitrogen-containing bisphosphonates should be switched to the non-nitrogen-containing bisphosphonates.
authors.affiliation: Singapore National Eye Centre, Singapore, Singapore.
authors.forename: Yar Li
authors.initials: YL
authors.lastname: Tan
authors.forename: Joanne
authors.initials: J
authors.lastname: Sims
authors.forename: Soon Phaik
authors.initials: SP
authors.lastname: Chee
mesh_terms: D000369:Aged, 80 and over; D001847:Bone Diseases / Q000188:drug therapy*; D004164:Diphosphonates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D013256:Steroids / Q000008:administration & dosage; D014605:Uveitis / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D004164:Diphosphonates; D013256:Steroids