title: Mechanical design optimization of bioabsorbable fixation devices for bone fractures.
abstract: Bioabsorbable bone plates can eliminate the necessity for a permanent implant when used to fixate fractures of the human mandible. They are currently not in widespread use because of the low strength of the materials and the requisite large volume of the resulting bone plate. The aim of the current study was to discover a minimally invasive bioabsorbable bone plate design that can provide the same mechanical stability as a standard titanium bone plate. A finite element model of a mandible with a fracture in the body region is subjected to bite loads that are common to patients postsurgery. The model is used first to determine benchmark stress and strain values for a titanium plate. These values are then set as the limits within which the bioabsorbable bone plate must comply. The model is then modified to consider a bone plate made of the polymer poly-L/DL-lactide 70/30. An optimization routine is run to determine the smallest volume of bioabsorbable bone plate that can perform and a titanium bone plate when fixating fractures of this considered type. Two design parameters are varied for the bone plate design during the optimization analysis. The analysis determined that a strut style poly-L-lactide-co-DL-lactide plate of 690 mm2 can provide as much mechanical stability as a similar titanium design structure of 172 mm2. The model has determined a bioabsorbable bone plate design that is as strong as a titanium plate when fixating fractures of the load-bearing mandible. This is an intriguing outcome, considering that the polymer material has only 6% of the stiffness of titanium.
authors.affiliation: Department of Mechanical Engineering, University of New Mexico, Albuquerque, New Mexico 87106, USA. lovalds@unm.edu
authors.forename: Scott T
authors.initials: ST
authors.lastname: Lovald
authors.forename: Tariq
authors.initials: T
authors.lastname: Khraishi
authors.forename: Jon
authors.initials: J
authors.lastname: Wagner
authors.forename: Bret
authors.initials: B
authors.lastname: Baack
mesh_terms: D020341:Absorbable Implants; D019985:Benchmarking; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D001732:Bite Force; D001860:Bone Plates; D001863:Bone Screws; D003743:Dental Enamel / Q000503:physiopathology; D003804:Dentin / Q000503:physiopathology; D004867:Equipment Design; D020342:Finite Element Analysis; D005592:Fracture Fixation / Q000295:instrumentation; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008334:Mandible / Q000503:physiopathology; D008337:Mandibular Fractures / Q000601:surgery*; D019060:Minimally Invasive Surgical Procedures / Q000295:instrumentation; D008954:Models, Biological; D009984:Orthopedic Fixation Devices; D010513:Periodontal Ligament / Q000503:physiopathology; D011091:Polyesters / Q000737:chemistry; D013314:Stress, Mechanical; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry; D055815:Young Adult
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide); D014025:Titanium