title: Surgical treatment of low- and intermediate-risk papillary thyroid cancer with minimally invasive video-assisted thyroidectomy.
abstract: BACKGROUND
  Minimally invasive video-assisted thyroidectomy (MIVAT) was introduced in the clinical practice to treat small benign thyroid nodules. This method has recently been demonstrated to produce the same completeness as a conventional thyroidectomy in patients with papillary thyroid cancer (PTC). The low number of treated cases and the limited follow-up of these patients represent the major limitations of these studies.
  
  
  OBJECTIVE
  The aim of the study was to compare the outcome of two groups of PTC patients, one treated with MIVAT and the other with conventional thyroidectomy, after a median follow-up of 5 yr.
  
  
  METHODS
  A total of 221 PTC patients were enrolled in this study according to the following criteria: 171 were treated with MIVAT (group A), and 50 were treated with conventional thyroidectomy (group B).
  
  
  RESULTS
  The outcome and the cumulative (131)I activity administered to achieve curative status were compared. After a mean follow-up of 3.6 +/- 1.5 yr (range, 1-8 yr; median, 5 yr), no differences were found between group A and group B. A similar rate of permanent hypoparathyroidism and/or nerve cord palsy was found in both groups.
  
  
  CONCLUSIONS
  We demonstrated that PTC patients operated on with MIVAT had a good outcome after 5 yr. This was similar to the outcome of patients treated with conventional thyroidectomy and the same degree of exposure to (131)I. These results, together with the evidence of a similar degree of completeness and rate of complications between the two surgical techniques, show that MIVAT is a valid option to treat low- and intermediate-risk PTC patients.
authors.affiliation: Department of Surgery, University of Pisa, Via Roma 64, 56100 Pisa, Italy. p.miccoli@dc.med.unipi.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Miccoli
authors.forename: Aldo
authors.initials: A
authors.lastname: Pinchera
authors.forename: Gabriele
authors.initials: G
authors.lastname: Materazzi
authors.forename: Agnese
authors.initials: A
authors.lastname: Biagini
authors.forename: Piero
authors.initials: P
authors.lastname: Berti
authors.forename: Pinuccia
authors.initials: P
authors.lastname: Faviana
authors.forename: Eleonora
authors.initials: E
authors.lastname: Molinaro
authors.forename: David
authors.initials: D
authors.lastname: Viola
authors.forename: Rossella
authors.initials: R
authors.lastname: Elisei
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007011:Hypoparathyroidism / Q000453:epidemiology / Q000209:etiology; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D010243:Paralysis / Q000453:epidemiology / Q000209:etiology; D011183:Postoperative Complications / Q000453:epidemiology; D012306:Risk; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D013965:Thyroidectomy / Q000009:adverse effects / Q000379:methods*; D016896:Treatment Outcome; D020535:Video-Assisted Surgery / Q000009:adverse effects / Q000379:methods*; D055815:Young Adult
chemical_list: D007457:Iodine Radioisotopes