title: Cobalt-catalyzed N-arylation of nitrogen nucleophiles in water.
abstract: Cobalt 'n' cross-coupling! A facile and practical strategy catalyzed by CoCl(2)6 H(2)O has been developed for the N-arylation of nitrogen nucleophiles with substituted aryl halides in water. The protocol is very simple and requires only mild conditions. A variety of nitrogen nucleophiles, including pyrazole, indole, and 7-azaindole, undergo catalysis to afford N-arylated products in moderate to good yields (up to 86 %; see scheme).
authors.affiliation: Natural Sciences and Science Education, National Institute of Education, Nanyang Technological University, 1 Nanyang Walk, Singapore. yongchua.teo@nie.edu.sg
authors.forename: Yong-Chua
authors.initials: YC
authors.lastname: Teo
authors.forename: Guan-Leong
authors.initials: GL
authors.lastname: Chua