title: Steric modulation of chiral biaryl diamines via Pd-catalyzed directed C-H arylation.
abstract: Palladium-catalyzed directed arylation of 2,2'-diacetamidobiaryls with aryl iodides provides efficient access to chiral ortho-substituted biaryl diamines. Aryl iodides with para- and meta-substituents are tolerated. Deprotection of the acetyl groups under basic conditions furnishes the free diamines, which should find broad utility in asymmetric catalysis.
authors.affiliation: Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA.
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Scarborough
authors.forename: Richard I
authors.initials: RI
authors.lastname: McDonald
authors.forename: Caroline
authors.initials: C
authors.lastname: Hartmann
authors.forename: Graham T
authors.initials: GT
authors.lastname: Sazama
authors.forename: Ana
authors.initials: A
authors.lastname: Bergant
authors.forename: Shannon S
authors.initials: SS
authors.lastname: Stahl
mesh_terms: D002384:Catalysis; D003959:Diamines / Q000138:chemical synthesis*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D010165:Palladium
chemical_list: D003959:Diamines; D006841:Hydrocarbons, Aromatic; D010165:Palladium