title: Admission blood glucose is an independent predictive factor for hospital mortality in polytraumatised patients.
abstract: OBJECTIVE
  The goal of this study was to analyse a possible association of admission blood glucose with hospital mortality of polytraumatised patients and to develop an outcome prediction model for this patient group.
  
  
  METHODS
  The outcome of adult polytraumatised patients admitted to the University Hospital of Berne, Switzerland, between 2002 and 2004 with an ISS > or = 17, and more than one severely injured organ system was retrospectively analysed.
  
  
  RESULTS
  The inclusion criteria were met by 555 patients, of which 108 (19.5%) died. Hyperglycaemia proved to be an independent predictor for hospital mortality (P < 0.0001), following multiple regression analysis. After inclusion of admission blood glucose, the calculated mortality prediction model performed better than currently described models (P < 0.0001, AUC 0.924).
  
  
  CONCLUSIONS
  In this retrospective, single-centre study in polytraumatised patients, admission blood glucose proved to be an independent predictor of hospital mortality following regression analysis controlling for age, gender, injury severity and other laboratory parameters. A reliable admission blood glucose-based mortality prediction model for polytraumatised patients could be established. This observation may be helpful in improving the precision of future outcome prediction models for polytraumatised patients. These observations warrant further prospective evaluation.
authors.affiliation: Department of Anaesthesiology and Critical Care Medicine, Innsbruck Medical University, Innsbruck, Austria. janett.kreutziger@uki.at
authors.forename: Janett
authors.initials: J
authors.lastname: Kreutziger
authors.forename: Volker
authors.initials: V
authors.lastname: Wenzel
authors.forename: Andrea
authors.initials: A
authors.lastname: Kurz
authors.forename: Mihai Adrian
authors.initials: MA
authors.lastname: Constantinescu
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D016001:Confidence Intervals; D004636:Emergency Service, Hospital; D005260:Female; D005544:Forecasting; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000401:mortality* / Q000503:physiopathology; D016017:Odds Ratio; D010343:Patient Admission; D012189:Retrospective Studies; D016019:Survival Analysis; D013557:Switzerland / Q000453:epidemiology; D015599:Trauma Severity Indices
chemical_list: D001786:Blood Glucose