Citrate-mediated release of aurintricarboxylic acid from a calcium alginate complex: implications for intravaginal HIV chemoprophylaxis and related applications.
Factors associated with the intravaginal release of an anti-HIV agent from an alginate complex were considered. Among these is citrate associated with prostatic fluid. This study demonstrates that citrate, at a physiologically appropriate concentration, facilitates the release of an anti-HIV polymer from a calcium alginate complex. The release of the agent can be modified by the concentration of the calcium and alginate in the complex. These results suggest that seminal and prostatic fluid can be considered in the design of an intravaginal system for HIV chemoprophylaxis.
Fong
Krystin
K
Department of Physiology and Pharmacology, Thomas J Long School of Pharmacy and Health Sciences, University of the Pacific, Stockton, California, USA.
Smith
Timothy J
TJ
D000282:Administration, Intravaginal; D000464:Alginates / Q000737:chemistry*; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000737:chemistry*; D001312:Aurintricarboxylic Acid / Q000008:administration & dosage / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002951:Citrates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D015658:HIV Infections / Q000517:prevention & control; D006603:Hexuronic Acids / Q000737:chemistry; D000077559:Sodium Citrate; D012995:Solubility
D000464:Alginates; D019380:Anti-HIV Agents; D002951:Citrates; D004337:Drug Carriers; D006603:Hexuronic Acids; D000077559:Sodium Citrate; D001312:Aurintricarboxylic Acid; D020723:Glucuronic Acid