title: [Relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation].
abstract: OBJECTIVE
  To explore the relationship between protein oxidation levels in the follicular fluid and the outcome parameters of in vitro fertilization-embryo transplantation (IVF-ET).
  
  
  METHODS
  The levels of advanced oxidation protein products (AOPP) in the follicular fluid were measured in 64 women with tubal infertility undergoing IVF-ET. The relationship between the AOPP levels and IVF-ET outcome parameters was analyzed.
  
  
  RESULTS
  AOPP levels showed significant inverse correlations between the proportion of mature oocytes (r=-0.401, P=0.001), fertilization rate (r=-0.257, P=0.045), cleavage rate (r=-0.290, P=0.024) and good embryo rate (r=-0.520, P=0.000). AOPP levels differed significantly between the groups with different retrieved oocyte numbers (F=3.851, P=0.027), being the lowest in women with 8 to 15 retrieved oocytes and the highest in those with retrieved oocytes below 8. The AOPP level in the non-pregnant women was significantly higher than that in the pregnant women (t=3.665, P=0.001). The AOPP levels also differed significantly with age (F=15.919, P=0.000), and the women >35 years of age had the highest level and those below 30 years had the lowest level.
  
  
  CONCLUSIONS
  Protein oxidative stress is present in the follicular fluid of women on IVF-ET cycles. High level of AOPP may have adverse effects on the oocytes and early embryonic development and may affect the outcome of IVF-ET.
authors.affiliation: Reproductive Technology Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. syl950446@126.com
authors.forename: Ya-li
authors.initials: YL
authors.lastname: Song
authors.forename: Song
authors.initials: S
authors.lastname: Quan
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Tian
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Si-mei
authors.initials: SM
authors.lastname: Chen
authors.forename: Fu-qi
authors.initials: FQ
authors.lastname: Xing
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007247:Infertility, Female / Q000378:metabolism / Q000628:therapy; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011247:Pregnancy; D018873:Pregnancy Rate; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins