Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study.
G72 is one of the most widely tested genes for association with schizophrenia. As G72 activates the D-amino acid oxidase (DAO), G72 is termed D-amino acid oxidase activator (DAOA). The aim of this study is to investigate the association between G72 and schizophrenia in a Japanese population, using the largest sample size to date (1774 patients with schizophrenia and 2092 healthy controls). We examined eight single nucleotide polymorphisms (SNPs), which had been associated with schizophrenia in previous studies. We found nominal evidence for association of alleles, M22/rs778293, M23/rs3918342 and M24/rs1421292, and the genotype of M22/rs778293 with schizophrenia, although there was no association of allele or genotype in the other five SNPs. We also found nominal haplotypic association, including M15/rs2391191 and M19/rs778294 with schizophrenia. However, these associations were no longer positive after correction for multiple testing. We conclude that G72 might not play a major role in the risk for schizophrenia in the Japanese population.
Ohi
Kazutaka
K
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
Hashimoto
Ryota
R
Yasuda
Yuka
Y
Yoshida
Tetsuhiko
T
Takahashi
Hidetoshi
H
Iike
Naomi
N
Fukumoto
Motoyuki
M
Takamura
Hironori
H
Iwase
Masao
M
Kamino
Kouzin
K
Ishii
Ryouhei
R
Kazui
Hiroaki
H
Sekiyama
Ryuji
R
Kitamura
Yuri
Y
Azechi
Michiyo
M
Ikezawa
Koji
K
Kurimoto
Ryu
R
Kamagata
Eiichiro
E
Tanimukai
Hitoshi
H
Tagami
Shinji
S
Morihara
Takashi
T
Ogasawara
Masayuki
M
Okochi
Masayasu
M
Tokunaga
Hiromasa
H
Numata
Shusuke
S
Ikeda
Masashi
M
Ohnuma
Tohru
T
Ueno
Shu-Ichi
S
Fukunaga
Tomoko
T
Tanaka
Toshihisa
T
Kudo
Takashi
T
Arai
Heii
H
Ohmori
Tetsuro
T
Iwata
Nakao
N
Ozaki
Norio
N
Takeda
Masatoshi
M
D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics*
D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins; D016194:Receptors, N-Methyl-D-Aspartate