title: Antagomirzymes: oligonucleotide enzymes that specifically silence microRNA function.
abstract: Many important cellular processes are regulated by small endogenous noncoding RNAs known as microRNAs (miRNAs). The precise molecular function of many miRNAs is unknown; different loss-of-function methods are required to gain insight into the biology of these small RNA molecules. Nucleic acid enzymes termed antagomirzymes are now shown to be valuable tools for the specific knockdown of miRNA in vitro and in vivo (see scheme).
authors.affiliation: Institute for Genomics and Integrative Biology, CSIR, Mall Road, Delhi 110 007, India.
authors.forename: Vaibhav M
authors.initials: VM
authors.lastname: Jadhav
authors.forename: Vinod
authors.initials: V
authors.lastname: Scaria
authors.forename: Souvik
authors.initials: S
authors.lastname: Maiti
mesh_terms: D001483:Base Sequence; D002460:Cell Line; D021881:DNA, Catalytic / Q000737:chemistry* / Q000378:metabolism; D017930:Genes, Reporter; D006801:Humans; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry*; D034622:RNA Interference
chemical_list: D021881:DNA, Catalytic; D035683:MicroRNAs; D009841:Oligonucleotides