title: [Pharmacotherapy quality and patient safety in haemodialysis patients treated with erythropoiesis-stimulating agents].
abstract: OBJECTIVE
  To assess an interdisciplinary programme for the improvement of pharmacotherapy quality and patient safety in patients with chronic renal disease who are treated with erythropoiesis-stimulating agents.
  
  
  METHODS
  Observational, longitudinal study. Retrospective analysis (period A) and prospective analysis (period B) following implementation of the programme for haemoglobin values and monthly erythropoiesis-stimulating agent dosage. The proportion of patients with haemoglobin values within the target range (10-5-12.5 g/dl) and those with values above the safety limit (>or= 12.5g/dl) were compared every four months and the average percentage of time with haemoglobin values within the target range and above the safety limit were compared during periods A and B.
  
  
  RESULTS
  59 patients were included in the study. The proportion of patients with haemoglobin levels within the target range increased from 28.8% to 65.4% (RR = 2.27; 95% CI, 1.56-3.30) and the value in patients with haemoglobin levels above the safe level reduced from 57.6% to 19.2% (RAR = 0.39; 95% CI, 0.19-0.55). The time with haemoglobin levels in the target range increased 15.7% (95% CI, 7.1-24.2) and the time with values above the safe level reduced 26.9% (95% CI, -35.1 to -18.6). The number of patients included to avoid one reaching a haemoglobin value above the safe range was 2.6 (95% CI, 2.5-2.7).
  
  
  CONCLUSIONS
  the implementation of an improvement programme for the quality of pharmacotherapy with erythropoiesis-stimulating agents in patients with haemodialysis significantly increases the proportion of patients with haemoglobin values within the recommended ranges of effectiveness and safety.
authors.affiliation: Servicio de Farmacia, Hospital Universitario Doctor Peset, Valencia, España.
authors.forename: T
authors.initials: T
authors.lastname: de Diego Santos
authors.forename: M
authors.initials: M
authors.lastname: Climente Martí
authors.forename: E V
authors.initials: EV
authors.lastname: Albert Balaguer
authors.forename: N V
authors.initials: NV
authors.lastname: Jiménez Torres
mesh_terms: D000368:Aged; D000740:Anemia / Q000188:drug therapy*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006397:Hematinics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D012189:Retrospective Studies
chemical_list: D006397:Hematinics; D004921:Erythropoietin