Electron capture dissociation LC/MS/MS for bottom-up proteomics.
ECD is a fragmentation technique that exhibits unusual properties. It is useful in bottom-up proteomics as a complement to collisional dissociation for deriving additional sequence information, locating post-translational modifications, and revealing racemization of individual amino acids in a peptide sequence.
Zubarev
Roman A
RA
Laboratory for Biological and Medical Mass Spectrometry, Uppsala Biomedical Centrum, Uppsala, Sweden.
D000818:Animals; D002417:Cattle; D002853:Chromatography, Liquid / Q000379:methods*; D004583:Electrons; D040901:Proteomics / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*