Mitotic kinase dynamics of the active form of AMPK (phospho-AMPKalphaThr172) in human cancer cells.
When interrogating the activation status of AMP-activated protein kinase-measured as AMPKalpha(Thr172) phosphorylation-in tissue sections of human carcinomas and in cultured human cancer cells, the spatiotemporal dynamics of AMPK activity during the G(1)/S-to-M-phase transition strikingly resembles that of well-characterized "chromosomal passenger" proteins such as Aurora B, INCENP or Histone H3. The mitotic kinase behavior of the active form of AMPK may represent a candidate molecular link through which energy status directly influences tumorigenesis. A definitive elucidation of phospho-AMPKalpha(Thr172) in coordinating the chromosomal and cytoskeletal events of mitosis might radically amend our current perception of other AMPK-related diseases such as obesity, cardiac hypertrophy or accelerated aging syndromes.
Vazquez-Martin
Alejandro
A
López-Bonet
Eugeni
E
Oliveras-Ferraros
Cristina
C
Pérez-Martínez
Maria Carmen
MC
Bernadó
Luis
L
Menendez
Javier A
JA
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D064107:Aurora Kinase B; D064127:Aurora Kinases; D045744:Cell Line, Tumor; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D016193:G1 Phase; D006657:Histones / Q000378:metabolism; D006801:Humans; D008938:Mitosis; D009369:Neoplasms / Q000201:enzymology*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D016196:S Phase
D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; C083767:INCENP protein, human; C576921:AURKB protein, human; D064107:Aurora Kinase B; D064127:Aurora Kinases; D017346:Protein Serine-Threonine Kinases; D055372:AMP-Activated Protein Kinases