title: Changes in artistic style and behaviour in Parkinson's disease: dopamine and creativity.
abstract: We present a PD patient in whom dopamine agonists awoke a hidden creativity that led to a gradual increase in painting productivity evolving to a disruptive impulsive behaviour that shared many features with punding. A dramatic change in painting style related to a more emotional experience during the process of creation developed after treatment onset. This case suggests that changes in creativity in PD seem to be related to dopaminergic imbalance in the limbic system.
authors.affiliation: Movement Disorders Unit, Neurology Department, Sant Pau Hospital, Autonomous University of Barcelona, Sant Antoni Maria Claret 167, Barcelona 08025, Spain. jkulisevsky@santpau.es
authors.forename: Jaime
authors.initials: J
authors.lastname: Kulisevsky
authors.forename: Javier
authors.initials: J
authors.lastname: Pagonabarraga
authors.forename: Mercè
authors.initials: M
authors.lastname: Martinez-Corral
mesh_terms: D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001132:Arm / Q000294:innervation / Q000503:physiopathology; D001154:Art; D052160:Benzothiazoles / Q000008:administration & dosage / Q000009:adverse effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D000077465:Cabergoline; D003405:Creativity; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology / Q000523:psychology; D004298:Dopamine / Q000378:metabolism; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004873:Ergolines / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced / Q000503:physiopathology / Q000523:psychology; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects / Q000502:physiology; D009770:Obsessive Behavior / Q000139:chemically induced* / Q000503:physiopathology / Q000523:psychology; D010151:Paintings; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D000077487:Pramipexole
chemical_list: D000978:Antiparkinson Agents; D052160:Benzothiazoles; D018491:Dopamine Agonists; D004873:Ergolines; D007980:Levodopa; D000077487:Pramipexole; D000077465:Cabergoline; D004298:Dopamine