title: Successful treatment of esophageal cancer with airway invasion with induction chemotherapy and concurrent chemoradiotherapy.
abstract: Esophageal cancer with airway invasion with or without fistula presents a challenging therapeutic dilemma with no standard therapy. Recent studies in Japan have focused on the use of definitive chemoradiotherapy. However, this approach is associated with significant treatment-related morbidity and mortality. We present a case report of a patient with thoracic esophageal squamous cell carcinoma with bronchial invasion who was treated to a clinical complete response with induction chemotherapy followed by consolidation with concurrent chemoradiotherapy. The patient also underwent restaging with a positron emission tomography scan after induction chemotherapy. Such a staged approach may reduce the morbidity of upfront radiation. The use of an interim positron emission tomography scan may also identify early treatment failure.
authors.affiliation: Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Geoffrey Y
authors.initials: GY
authors.lastname: Ku
authors.forename: Karyn A
authors.initials: KA
authors.lastname: Goodman
authors.forename: Valerie W
authors.initials: VW
authors.lastname: Rusch
authors.forename: David H
authors.initials: DH
authors.lastname: Ilson
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001984:Bronchial Neoplasms / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003680:Deglutition Disorders / Q000175:diagnosis / Q000209:etiology; D019160:Endosonography; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D018714:Radiotherapy, Adjuvant; D018570:Risk Assessment; D016896:Treatment Outcome