title: Synthesis, characterization and biological activities of mixed ligand Zr(IV) complexes.
abstract: Mixed ligand ternary Zr(IV) complexes of type [M(Q)2LNO3xH2O] have been synthesized using 8-hydroxyquinoline (HQ) as a primary ligand and N- and/O-donor amino acids (HL) such as L-serine, L-alanine and glycine as secondary ligands. These complexes were characterized on the basis of elemental analysis, conductance measurement, spectral and thermal studies. The molar conductance study of the complexes in DMF solvent signifies their non-electrolytic nature whereas the thermal analyses specify presence of a coordinated water molecule. The complexes were tested for antifungal and antibacterial activity by using agar well diffusion bioassay. The antibacterial activity was tested against the pathogenic bacteria Staphylococcus aureus and Enterococcus faecium. The results obtained were evaluated with antibacterial standard vancomycin. The antifungal activity was tested against Candida albicans, Candida krusei, Aspergillus fumigatus and the results obtained were compared with antifungal standard amphotericin B. The complexes were also screened for cytotoxicity studies against Ehrlich ascites cells and Daltons lymphoma ascites cells and show very low cytotoxicity.
authors.affiliation: Department of Chemistry, The Institute of Science, 15, Madam Cama Road, Mumbai-400 032, India. ymalghe@yahoo.com
authors.forename: Yuvraj S
authors.initials: YS
authors.lastname: Malghe
authors.forename: Rakesh C
authors.initials: RC
authors.lastname: Prabhu
authors.forename: Rajesh W
authors.initials: RW
authors.lastname: Raut
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor; D045744:Cell Line, Tumor; D008024:Ligands; D015125:Oxyquinoline / Q000737:chemistry; D014640:Vancomycin / Q000494:pharmacology; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D008024:Ligands; D015125:Oxyquinoline; D014640:Vancomycin; D000666:Amphotericin B; D015040:Zirconium