[Gamma interferon: basics aspects, clinic significance and terapeutic uses].
Interferons are a family of pleiotropic cytokines, their name was assigned because of their anti-replicative viral activity. IFNgamma or immune type II interferon does not share receptors with the type I interferon, its structure is different and its gene is located in different chromosome, although its biologic effects are similar. Along of several years of research, it has been found that IFNgamma enhances the transcription of genes involved in immunomodulation, antiviral responses and antitumoral activities. Regarding to the immune system, IFNgamma increases the cytotoxic and phagocytic activity of macrophages and upregulates the expression of major histocompatibility complex (MHC) class I and class II molecules in dendritics cells and other antigen presenting cells. IFNgamma also promotes the development and differentiation of naive CD4+ T lymphocytes to Th1 helper subset. Indeed, this cytokine has a key role in the control of bacterial, micotic, viral and parasitic infections. Depending of the micro-environment, IFNgamma has a dual role as pro or anti inflammatory cytokine. Novel therapeutic strategies are currently being developed with the aim to enhance the immune response or replace IFNgamma gene abnormal expression with beneficial results in humans, being recombinant IFNgamma safe and well tolerated.
Mata-Espinosa
Dulce A
DA
Departamento de Patología, Sección de Patologia Experimental, Instituto Nacional de Ciencias M6dicas y Nutrición Salvador Zubirán, DF México. dmata@ifc.unam.mx
Hernández-Pando
Rogelio
R
D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology / Q000628:therapy; D004353:Drug Evaluation, Preclinical; D005786:Gene Expression Regulation; D006105:Granulomatous Disease, Chronic / Q000628:therapy; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007239:Infections / Q000503:physiopathology / Q000628:therapy; D007249:Inflammation / Q000503:physiopathology / Q000628:therapy; D007371:Interferon-gamma / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000502:physiology* / Q000627:therapeutic use; D053612:Janus Kinases / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy; D011487:Protein Conformation; D051381:Rats; D017471:Receptors, Interferon / Q000737:chemistry / Q000502:physiology; D050791:STAT Transcription Factors / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D000096743:Interferon gamma Receptor
D007155:Immunologic Factors; D007371:Interferon-gamma; D053612:Janus Kinases; D017471:Receptors, Interferon; D050791:STAT Transcription Factors; D000096743:Interferon gamma Receptor