Advances in bioluminescence imaging of live animal models.
Many of the obligate steps of physiology and disease are dynamic in time and space, and thus, end-point assays do not always provide a full understanding of these processes. Comprehensive understanding of the functional complexity of protein interactions and cell trafficking requires mapping of cellular and molecular function within complex systems over biologically relevant time scales. New approaches to bioluminescence imaging of cell migration, signaling pathways, drug action, and interacting protein partners in vivo allow the study of biology and disease within the context of living animals.
Dothager
Robin S
RS
Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO 63110, USA. dothagerr@mir.wustl.edu
Flentie
Kelly
K
Moss
Britney
B
Pan
Mei-Hsiu
MH
Kesarwala
Aparna
A
Piwnica-Worms
David
D
D000818:Animals; D002318:Cardiovascular Diseases / Q000473:pathology; D003141:Communicable Diseases / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods*; D004195:Disease Models, Animal; D008163:Luminescent Measurements / Q000379:methods*; D009369:Neoplasms / Q000473:pathology