[The action of TSG101 on HIV-1 budding and related inhibitors].
tsg101 gene is a newly found tumor suppressor gene whose product TSG101 has many important biological functions. Recent research of TSG101 has revealed that TSG101 aids HIV-1 budding from infected cells by attaching to Gag. HIV-1 budding is arrested in the cells with mutant TSG101 or without TSG101. So TSG101 would be a useful target for anti-HIV drug design. Now there is already some research on anti-HIV agents based on TSG101 structure. In this article the structure and function of TSG101 as well as the related inhibitors were reviewed.
Chen
Hong-fei
HF
Institute of Medicinal Chemistry, School of Pharmacy, Shandong University, Jinan 250012, China.
Liu
Xin-yong
XY
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D056827:Endosomal Sorting Complexes Required for Transport / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D015497:HIV-1 / Q000254:growth & development* / Q000502:physiology; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D014779:Virus Replication; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*; D000099177:Tsg101 Protein
D019380:Anti-HIV Agents; D004268:DNA-Binding Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D014157:Transcription Factors; D054301:gag Gene Products, Human Immunodeficiency Virus; D000099177:Tsg101 Protein