title: Effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors in rat brain.
abstract: We studied the effect of muramyl dipeptides on postsynaptic GABA, NMDA, and AMPA receptors and presynaptic NMDA receptors. L,D-Dipeptide more potently than L,L-dipeptide inhibited postsynaptic NMDA receptors, potentiated GABA and AMPA receptors, and inhibited (45)Ca(2+) uptake in synaptosomes from of rat brain cortex. Our results indicate that muramyl dipeptides modulate function of glutamate and GABA receptors.
authors.affiliation: Laboratory for Neurochemistry of Physiologically Active Substances, Institute of Physiologically Active Substances, Russian Academy Sciences, Chernogolovka, Moscow region, Russia. grigor@ipac.ac.ru
authors.forename: V V
authors.initials: VV
authors.lastname: Grigoriev
authors.forename: L N
authors.initials: LN
authors.lastname: Petrova
authors.forename: A V
authors.initials: AV
authors.lastname: Gabreliyan
authors.forename: T A
authors.initials: TA
authors.lastname: Ivanova
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D002118:Calcium / Q000378:metabolism; D018408:Patch-Clamp Techniques; D017729:Presynaptic Terminals / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000187:drug effects* / Q000502:physiology; D018079:Receptors, GABA / Q000187:drug effects* / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000502:physiology; D013237:Stereoisomerism; D009435:Synaptic Transmission / Q000187:drug effects
chemical_list: D018091:Receptors, AMPA; D018079:Receptors, GABA; D016194:Receptors, N-Methyl-D-Aspartate; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D002118:Calcium