A review of pulmonary coagulopathy in acute lung injury, acute respiratory distress syndrome and pneumonia.
Enhanced bronchoalveolar coagulation is a hallmark of many acute inflammatory lung diseases such as acute lung injury, acute respiratory distress syndrome and pneumonia. Intervention with natural anticoagulants in these diseases has therefore become a topic of interest. Recently, new data on the role of pulmonary coagulation and inflammation has become available. The aim of this review is to summarize these findings. Furthermore, the results of anticoagulant therapeutic interventions in these disorders are discussed.
Nieuwenhuizen
Laurens
L
Department of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands. l.nieuwenhuizen@antonius.net
de Groot
Philip G
PG
Grutters
Jan C
JC
Biesma
Douwe H
DH
D055371:Acute Lung Injury / Q000097:blood*; D006801:Humans; D011014:Pneumonia / Q000097:blood*; D011652:Pulmonary Circulation; D012128:Respiratory Distress Syndrome / Q000097:blood*; D019851:Thrombophilia / Q000209:etiology*