The curious case of a wandering kinase: CaMKII spreads the wealth?
Calcium/calmodulin-dependent kinase II has been suggested to produce input-specific long-term potentiation of synaptic strength. This idea has been complicated by results from Rose, Jin, and Craig demonstrating that spatiotemporally restricted NMDA receptor excitation at contiguous synapses can result in the translocation of activated CaMKII throughout the dendritic arbor.
Klassen
Matthew P
MP
Neurosciences Program, 385 Serra Mall, Herrin Labs, Room 144, Stanford University, Stanford, CA 94305, USA.
Shen
Kang
K
D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D020013:Calcium Signaling / Q000502:physiology; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013569:Synapses / Q000201:enzymology* / Q000648:ultrastructure; D009435:Synaptic Transmission / Q000502:physiology*
D016194:Receptors, N-Methyl-D-Aspartate; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2