Histological analysis of calcium phosphate bone grafts for surgically created periodontal bone defects in dogs.
A calcium phosphate cement (CPC-1), prepared by mixing an equimolar mixture of tetracalcium phosphate and dicalcium phosphate anhydrous with water, has been shown to be highly biocompatible and osteoconductive. A new type of calcium phosphate cement (CPC-2), prepared by mixing a mixture of alpha-tricalcium phosphate and calcium carbonate with pH 7.4 sodium phosphate solution, was also reported to be highly biocompatible. The objective of the present study was to compare the osteoconductivities of CPC-1 and CPC-2 when implanted in surgically created defects in the jaw bones of dogs. At 1 month after surgery, implanted CPC-1 was partially replaced by new bone and converted to bone within 6 months. In comparison, at 1 month after surgery, the defect filled with CPC-2 was mostly replaced by new bone. Therefore, bone formation in CPC-2-filled pocket was more rapid than in CPC-1-filled pocket. These findings supported the hypothesis that CPC-2 converted to bone more rapidly than CPC-1.
Sugawara
Akiyoshi
A
Sugawara Dental Clinic, Tokyo, Japan. aki@dr-sugawara.com
Fujikawa
Kenji
K
Takagi
Shozo
S
Chow
Laurence C
LC
D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000627:therapeutic use*; D001843:Bone Cements / Q000138:chemical synthesis / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000737:chemistry; D002130:Calcium Phosphates / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use*; D003238:Connective Tissue / Q000473:pathology; D004285:Dogs; D017886:Durapatite / Q000737:chemistry; D006097:Granulation Tissue / Q000473:pathology; D006863:Hydrogen-Ion Concentration; D008334:Mandible / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010012:Osteogenesis / Q000187:drug effects; D010710:Phosphates / Q000737:chemistry; D011897:Random Allocation; D013524:Surgical Flaps; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D010710:Phosphates; C485828:alpha-tricalcium phosphate; D017886:Durapatite; C020243:calcium phosphate; D002119:Calcium Carbonate; C018392:tricalcium phosphate; C485829:calcium phosphate, dibasic, anhydrous; C018279:sodium phosphate