Spontaneous quinolone resistance in the zoonotic serovar of Vibrio vulnificus.
This work demonstrates that Vibrio vulnificus biotype 2, serovar E, an eel pathogen able to infect humans, can become resistant to quinolone by specific mutations in gyrA (substitution of isoleucine for serine at position 83) and to some fluoroquinolones by additional mutations in parC (substitution of lysine for serine at position 85). Thus, to avoid the selection of resistant strains that are potentially pathogenic for humans, antibiotics other than quinolones must be used to treat vibriosis on farms.
Roig
Francisco J
FJ
Departamento de Microbiología, Facultad de Biología, Universidad de Valencia, Valencia, Spain.
Llorens
A
A
Fouz
B
B
Amaro
C
C
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D027081:DNA Gyrase / Q000235:genetics; D027101:DNA Topoisomerase IV / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024881:Drug Resistance, Bacterial; D004524:Eels / Q000382:microbiology; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D015363:Quinolones / Q000494:pharmacology*; D017422:Sequence Analysis, DNA; D041261:Vibrio vulnificus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D015363:Quinolones; D027101:DNA Topoisomerase IV; D027081:DNA Gyrase