title: Necrolytic acral erythema without hepatitis C infection.
abstract: Necrolytic acral erythema is a newly described entity characterized by sharply demarcated scaly plaques on the dorsum of the hands and feet. More than 30 patients have been reported since 1996, all of whom had anti-hepatitis C virus antibody. A 32-year-old Taiwanese woman had been diagnosed with and treated for systemic lupus erythematosus with lupus nephritis about 10 years earlier. Soon thereafter, she noted several well-demarcated keratotic plaques with erythematous borders on her feet, with sparing of the soles. Histopathology showed diffuse parakeratosis with a neutrophil infiltrate, hypogranulosis, pale upper keratinocytes, scattered and grouped dyskeratotic cells, psoriasiform hyperplasia and a mild lymphocytic infiltrate in the upper dermis. The diagnosis was made after three biopsies. The lesions regularly worsened just before and during menstruation, but patch and intradermal tests for progesterone and estrogen were negative. There was no evidence of either hepatitis B or hepatitis C infection. The lesions did not respond to treatment with zinc. The rash regressed spontaneously when corticosteroids were stopped and recurred when they were restarted, finally resolving completely after she was treated with high-dose pulse steroids for her lupus.
authors.affiliation: Department of Dermatology, Mackay Memorial Hospital, Taipei, Taiwan. yuhung_wu@yahoo.com
authors.forename: Yu-Hung
authors.initials: YH
authors.lastname: Wu
authors.forename: Mei-Eng
authors.initials: ME
authors.lastname: Tu
authors.forename: Chyou-Shen
authors.initials: CS
authors.lastname: Lee
authors.forename: Yang-Chih
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000328:Adult; D044466:Asian People; D004890:Erythema / Q000139:chemically induced / Q000473:pathology*; D005260:Female; D006526:Hepatitis C; D006801:Humans; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000473:pathology; D008181:Lupus Nephritis / Q000178:diet therapy / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced / Q000473:pathology; D010241:Parakeratosis / Q000139:chemically induced / Q000473:pathology*; D012867:Skin / Q000473:pathology; D013256:Steroids / Q000008:administration & dosage / Q000009:adverse effects; D013624:Taiwan
chemical_list: D013256:Steroids