[Correlation analyses of ALDH2 and CYP2E1 genetic polymorphism with personality].
We examined relationship of acetaldehyde dehydrogenase 2 (ALDH2) and cytochrome P450 (CYP) 2E1 genetic polymorphism with personality. After written informed consent was obtained, each polymorphism was determined by PCR-RFLP, and personality assessment was evaluated by NEO-FFI, among 181 health university students. There was no significant relationship between ALDH2 and personality. However, the individuals with CYP2E1*1/*1 showed a significant higher O (openness) score than individuals with CYP2E1*5 allele (p<0.05). Furthermore, the individuals with both CYP2E1*5 and ALDH2*2 alleles showed a significant high E (extraversion) score (p<0.05). Our study suggested that CYP2E1*5 and ALDH2*2 alleles may relate to a part of the personality.
Ohtsuka
Yukinari
Y
Laboratory of Neurophysiology the Graduate School of Environmental Health Sciences, Azabu University, 1-17-71, Fuchinobe, Sagamihara, Kanagawa, 229-8501 Japan.
Aoki
Jun
J
Iwahashi
Kazuhiko
K
D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D019392:Cytochrome P-450 CYP2E1 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010551:Personality / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
D019392:Cytochrome P-450 CYP2E1; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial