Taurine haloamines and heme oxygenase-1 cooperate in the regulation of inflammation and attenuation of oxidative stress.
Taurine chloramine (TauCl) and Taurine bromamine (TauBr), products of the neutrophil myeloperoxidase halide system, exert anti-inflammatory properties. They inhibit the production of a variety of inflammatory mediators, such as prostaglandin E2 (PGE2), nitric oxide (NO) and proinflammatory cytokines. Heme oxygenase-1 (HO-1), a stress inducible enzyme, degrades heme to biliverdin, free iron and carbon monoxide (CO), which are involved in the anti-inflammatory and antioxidant actions of HO-1. Recently we have demonstrated that taurine haloamines induce the expression of HO-1 in inflammatory cells. In this study we examined whether HO-1 participates in taurine haloamines-mediated suppression of proinflammatory cytokine production. We have shown that TauCl/TauBr and CO inhibit the production of TNF-alpha, IL-12 and IL-6, in a similar dose-dependent manner. However, the suppressor activity of TauCl was not altered in HO-1 deficient mice. Therefore, HO-1 and TauCl may independently regulate the production of proinflammatory cytokines. We suggest that TauCl and TauBr provide a link between the two antioxidant systems: the cysteine pathway and the heme oxygenase system.
Marcinkiewicz
Janusz
J
Chair of Immunology, Institute of Rheumatology, Poland. mmmarcin@cyf-kr.edu.pl
Walczewska
Maria
M
Olszanecki
Rafał
R
Bobek
Małgorzata
M
Biedroń
Rafał
R
Dulak
Józef
J
Józkowicz
Alicja
A
Kontny
Ewa
E
Maślinski
Włodzimierz
W
D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006419:Heme Oxygenase (Decyclizing) / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D007249:Inflammation / Q000517:prevention & control*; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D018384:Oxidative Stress; D013654:Taurine / Q000031:analogs & derivatives* / Q000378:metabolism
D016207:Cytokines; D004791:Enzyme Inhibitors; D013654:Taurine; C043410:N-chlorotaurine; C052954:N-bromotaurine; D002248:Carbon Monoxide; D006419:Heme Oxygenase (Decyclizing)