Immunoexpression of keratins in the calcifying cystic odontogenic tumor epithelium.
Ameloblastomatous epithelium containing clusters of ghost cells is the typical histopathology of calcifying cystic odontogenic tumor (CCOT). This paper aimed to assess keratins AE1-AE3, K7, K10/13, K14, K18, K19, vimentin, laminin, and collagen IV in 08 CCOTs to discuss their histopathogenesis. Similarity to the immunoprofile of the stratified squamous epithelium was seen in the with the basal layer expressing K14 and the upper cells expressing K10/13. When compared to the immunoprofile of the normal odontogenic epithelium, of odontogenic tumor epithelia and of the ghost cells described in the literature, it was possible to suggest that the CCOT epithelium differentiates towards squamous type.
Crivelini
Marcelo Macedo
MM
Department of Pathology and Clinical Propaedeutic, Araçatuba College of Dentistry, São Paulo State University, São Paulo, Brazil. mmcrivel@foa.unesp.br
Felipini
Renata Callestini
RC
Coclete
Gilberto Aparecido
GA
Soubhia
Ana Maria Pires
AM
D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D024141:Collagen Type IV / Q000096:biosynthesis; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology*; D007633:Keratins / Q000096:biosynthesis*; D007797:Laminin / Q000096:biosynthesis; D018333:Odontogenic Cyst, Calcifying / Q000378:metabolism* / Q000473:pathology*; D014746:Vimentin / Q000096:biosynthesis
D024141:Collagen Type IV; D007797:Laminin; D014746:Vimentin; D007633:Keratins