Towards a durable RNAi gene therapy for HIV-AIDS.
BACKGROUND
RNA interference (RNAi) can be employed as a potent antiviral mechanism.


OBJECTIVE
To discuss RNAi approaches to target pathogenic human viruses causing acute or chronic infections, in particular RNAi gene therapy against HIV-1.


METHODS
A review of relevant literature.


CONCLUSIONS
The future of antiviral RNAi therapeutics is very promising. RNAi was discovered only a decade ago, and although we are still in the early days, the first clinical trials are already ongoing.
Berkhout
Ben
B
Academic Medical Center of the University of Amsterdam, Center for Infection and Immunity Amsterdam (CINIMA), Department of Medical Microbiology, Laboratory of Experimental Virology, Amsterdam, The Netherlands. b.berkhout@amc.uva.nl
ter Brake
Olivier
O
D015316:Genetic Therapy; D005822:Genetic Vectors; D015658:HIV Infections / Q000628:therapy*; D015497:HIV-1 / Q000235:genetics; D006801:Humans; D034622:RNA Interference