title: Serum pattern of circulating adipokines throughout the physiological menstrual cycle.
abstract: This study investigated the serum levels of resistin, adiponectin and leptin during the physiological menstrual cycle. Sixteen women (age: 19-30 years; body mass index: 19.46-24.9) with regular menstrual cycles participated. Fasting blood samples were collected on alternate days throughout a full menstrual cycle. Mean resistin concentrations were slightly higher during the luteal phase (5.30+/-0.23 ng/ml) compared to the follicular (4.68+/-0.07 ng/ml) and midcycle (4.86+/-0.09 ng/ml) phases (p=0.032). Mean leptin concentrations during the follicular phase (18.14+/-0.28 ng/ml) were significantly lower compared to the midcycle (21.79+/-0.29 ng/ml, p=0.006) and luteal phases (23.75+/-0.64 ng/ml, p<0.001). The variation of adiponectin concentrations throughout the menstrual cycle was not significant. According to the results, circulating resistin, likewise leptin concentrations vary significantly during the physiological menstrual cycle presenting with higher values during the luteal phase. This pattern, although its physiological importance is not clear, suggests that resistin, likewise to leptin, may have a role in the regulation of cyclic female reproductive functions. The stable adiponectin concentrations throughout the menstrual cycle indicate that this adipokine probably does not play a considerable role in female reproductive functions.
authors.affiliation: Laboratory of Physiology, School of Medicine, Democritus University of Thrace, Dragana, Alexandroupolis, Greece.
authors.forename: Byron
authors.initials: B
authors.lastname: Asimakopoulos
authors.forename: Athanasios
authors.initials: A
authors.lastname: Milousis
authors.forename: Theodora
authors.initials: T
authors.lastname: Gioka
authors.forename: Georgia
authors.initials: G
authors.lastname: Kabouromiti
authors.forename: George
authors.initials: G
authors.lastname: Gianisslis
authors.forename: Androniki
authors.initials: A
authors.lastname: Troussa
authors.forename: Mara
authors.initials: M
authors.lastname: Simopoulou
authors.forename: Simoni
authors.initials: S
authors.lastname: Katergari
authors.forename: Gregory
authors.initials: G
authors.lastname: Tripsianis
authors.forename: Nikos
authors.initials: N
authors.lastname: Nikolettos
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005498:Follicular Phase / Q000097:blood; D006801:Humans; D020738:Leptin / Q000097:blood*; D008183:Luteal Phase / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008597:Menstrual Cycle / Q000097:blood*; D011374:Progesterone / Q000097:blood; D052243:Resistin / Q000097:blood*
chemical_list: D052242:Adiponectin; D020738:Leptin; D052243:Resistin; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone