title: Rapid screening of cognitive change in patients with questionable dementia using the Memory Impairment Screen and the Isaacs Set Test.
abstract: OBJECTIVE
  To assess the efficacy of combining the Memory Impairment Screen (MIS) and the Isaacs Set Test (IST) in predicting short-term development of dementia in a group of people with questionable dementia (QD) at baseline.
  
  
  METHODS
  Performances of the weighted sum of MIS and IST and the <<or>> rule were compared with each other and with the Mini-Mental State Examination.
  
  
  METHODS
  Database of the Regional Network for Diagnostic Aid and Management of Patients with Cognitive Impairment in the Franche-Comté geographical area in France.
  
  
  METHODS
  A cohort of 106 patients aged 65 and older with QD were followed up for a mean of 14.9 months (range 6-24 months).
  
  
  METHODS
  Sensitivity, specificity, positive predictive value, and negative predictive value were calculated for the combination of these two tests.
  
  
  RESULTS
  The weighted sum had a sensitivity of 0.74 and a specificity of 0.84. The <<or>> rule (MIS<6 or IST<25) had a sensitivity of 0.74 and a specificity of 0.81. When range values were applied, low scores on the MIS and the IST (MIS<6 and IST<25) led to a high probability of dementia, whereas high scores (MIS>7 and IST>29) suggested a high probability of remaining dementia-free in the study follow-up.
  
  
  CONCLUSIONS
  This quickly performed tool (5 minutes) is simple to use and score. When including cutscores (MIS<6 or IST<25) or range values, this test could be considered a useful screening procedure for all types of dementias.
authors.affiliation: Department of Neurology, Besançon University Hospital-Jean Minjoz, Besançon, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Chopard
authors.forename: Geraldine
authors.initials: G
authors.lastname: Vanholsbeeck
authors.forename: Gregory
authors.initials: G
authors.lastname: Tio
authors.forename: Alexandre
authors.initials: A
authors.lastname: Pitard
authors.forename: Mickael
authors.initials: M
authors.lastname: Binetruy
authors.forename: Lucien
authors.initials: L
authors.lastname: Rumbach
authors.forename: Jean
authors.initials: J
authors.lastname: Galmiche
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D003704:Dementia / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005602:France; D006801:Humans; D016015:Logistic Models; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008569:Memory Disorders / Q000175:diagnosis*; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity