Effect of drinking on adiponectin in healthy men and women: a randomized intervention study of water, ethanol, red wine, and beer with or without alcohol.
OBJECTIVE
Moderate alcohol consumption is associated with reduced incidence of type 2 diabetes and cardiovascular mortality and increases adiponectin concentrations, but effects might differ according to sex and beverage consumed.


METHODS
A total of 72 healthy individuals (22-56 years) were enrolled in this randomized controlled crossover trial. After washout, two interventions for 3 weeks followed: ethanol (concentration 12.5%), beer (5.6%), or red wine (12.5%) equivalent to 30 g ethanol/day for men and 20 g/day for women or the same de-alcoholized beverages or water. Adiponectin was measured by sandwich enzyme-linked immunosorbent assay.


RESULTS
Among women, adiponectin significantly increased after consuming red wine (29.8%, P < 0.05) and increased among men after ethanol solution (17.4%, P < 0.05) and consuming beer (16.1%, P < 0.05). De-alcoholized beverages had no substantial effect on adiponectin concentrations.


CONCLUSIONS
Moderate amounts of ethanol-containing beverages increased adiponectin concentrations, but sex-specific effects might depend on type of beverage consumed.
Imhof
Armin
A
Department of Internal Medicine II, Cardiology, University of Ulm, Ulm, Germany. armin.imhof@uni-ulm.de
Plamper
Ines
I
Maier
Steffen
S
Trischler
Gerlinde
G
Koenig
Wolfgang
W
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000428:Alcohol Drinking / Q000097:blood*; D001515:Beer; D018592:Cross-Over Studies; D004326:Drinking / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012727:Sex Characteristics; D013695:Temperance / Q000706:statistics & numerical data*; D014867:Water; D044465:White People; D014920:Wine; D055815:Young Adult
D052242:Adiponectin; D014867:Water