title: Delayed optic nerve complications after proton beam irradiation.
abstract: We present two cases of delayed optic nerve complications following proton beam radiotherapy. Patient 1 received radiotherapy after surgery for clival chordoma and developed sequential radiation optic neuropathy at 5 and 9 months. Patient 2 developed optic nerve hemorrhage post radiotherapy for optic nerve sheath meningioma. These two cases of blindness demonstrate the risks associated with proton beam radiotherapy.
authors.affiliation: Bascom Palmer Eye Institute, University of Miami, Miller School of Medicine, Miami, FL, USA. jchacko@uams.edu
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Chacko
authors.forename: Norman J
authors.initials: NJ
authors.lastname: Schatz
authors.forename: Joel S
authors.initials: JS
authors.lastname: Glaser
mesh_terms: D000328:Adult; D002817:Chordoma / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000532:radiotherapy; D008579:Meningioma / Q000532:radiotherapy; D008875:Middle Aged; D009900:Optic Nerve / Q000473:pathology / Q000528:radiation effects*; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D011522:Protons; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology*; D019292:Skull Base Neoplasms / Q000532:radiotherapy; D014792:Visual Acuity
chemical_list: D011522:Protons