title: [Updates on severe traumatic brain injury management].
abstract: Traumatic brain injury (TBI) is an important reason of morbidity-mortality all over the world, affecting young males more and generating Public Health problem. Unfortunately, the advances in the pathophysiology knowledge have not followed a similar development in therapeutic options, there currently not being any contrasted neuroprotectants. In this article, we have reviewed the epidemiology, pathophysiology and therapeutic measures used in the management of patient with severe TBI. The general measures as well as those aimed at controlling intracranial hypertension, the role of the surgery and some more innovative therapeutic options currently under evaluation in these patients are analyzed.
authors.affiliation: UCI Trauma, Servicio de Medicina Intensiva, Hospital Universitario 12 de Octubre, Madrid, España. ealted.hdoc@salud.madrid.org
authors.forename: Emilio
authors.initials: E
authors.lastname: Alted López
authors.forename: Susana Bermejo
authors.initials: SB
authors.lastname: Aznárez
authors.forename: Mario Chico
authors.initials: MC
authors.lastname: Fernández
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology / Q000517:prevention & control; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use; D001925:Brain Damage, Chronic / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D001930:Brain Injuries / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology / Q000628:therapy*; D003131:Combined Modality Therapy; D000075202:Contraindications; D019468:Disease Management; D004322:Drainage; D005260:Female; D005334:Fever / Q000209:etiology / Q000628:therapy; D005392:First Aid; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use; D007036:Hypothermia, Induced; D019586:Intracranial Hypertension / Q000209:etiology / Q000517:prevention & control / Q000628:therapy; D008297:Male; D009465:Neuromuscular Agents / Q000627:therapeutic use; D018696:Neuroprotective Agents / Q000627:therapeutic use; D019635:Neurosurgical Procedures; D012307:Risk Factors; D055815:Young Adult
chemical_list: D000700:Analgesics; D006993:Hypnotics and Sedatives; D009465:Neuromuscular Agents; D018696:Neuroprotective Agents