title: Type I natural killer T cells suppress tumors caused by p53 loss in mice.
abstract: CD1d-restricted T cells are considered to play a host protective effect in tumor immunity, yet the evidence for a role of natural killer T (NKT) cells in tumor immune surveillance has been weak and data from several tumor models has suggested that some (type II) CD1d-restricted T cells may also suppress some types of antitumor immune response. To substantiate an important role for CD1d-restricted T cells in host response to cancer, we have evaluated tumor development in p53(+/-) mice lacking either type I NKT cells (TCR Jalpha18(-/-)) or all CD1d-restricted T cells (CD1d(-/-)). Our findings support a key role for type I NKT cells in suppressing the onset of sarcomas and hematopoietic cancers caused by p53 loss but do not suggest that other CD1d-restricted T cells are critical in regulating the same tumor development.
authors.affiliation: Peter MacCallum Cancer Centre, East Melbourne, Australia.
authors.forename: Jeremy B
authors.initials: JB
authors.lastname: Swann
authors.forename: Adam P
authors.initials: AP
authors.lastname: Uldrich
authors.forename: Serani
authors.initials: S
authors.lastname: van Dommelen
authors.forename: Janelle
authors.initials: J
authors.lastname: Sharkey
authors.forename: William K
authors.initials: WK
authors.lastname: Murray
authors.forename: Dale I
authors.initials: DI
authors.lastname: Godfrey
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D055610:Antigens, CD1d / Q000235:genetics; D003433:Crosses, Genetic; D005260:Female; D017353:Gene Deletion; D019673:Genes, T-Cell Receptor alpha; D016158:Genes, p53; D007157:Immunologic Surveillance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D055611:Natural Killer T-Cells / Q000145:classification / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000235:genetics / Q000276:immunology*; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000276:immunology*; D047368:Tumor Burden
chemical_list: D055610:Antigens, CD1d; C526879:Cd1d1 protein, mouse