The role of mesangial homeostasis in glomerular injury progression: hope for mesangial sclerosis reversal.
Paraprotein-induced renal injury is associated with diverse pathologies and is a common cause of renal failure. In one form, mature light chain deposition disease, development of mesangial nodules, reminiscent of those seen in diabetic nephropathy, is a characteristic feature universally associated with disease progression. Keeling and Herrera have demonstrated the development of such nodules in vitro using a human mesangial cell culture model. Lessons learned from this model might be applicable to other types of glomerular sclerosis.
Picken
Maria M
MM
Department of Pathology, Loyola University, Chicago, Illinois, USA. mpicken@lumc.edu
D002478:Cells, Cultured; D006706:Homeostasis; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology*; D007678:Kidney Glomerulus / Q000473:pathology*; D050527:Mesangial Cells / Q000473:pathology*; D010266:Paraproteins; D012598:Sclerosis / Q000628:therapy
D010266:Paraproteins