title: MHC molecules and microbial antigen processing in phagosomes.
abstract: Macrophages and dendritic cells are phagocytic antigen presenting cells that internalize bacteria and other particulate antigens into phagosomes. The phagosome must then balance microbicidal and proteolytic degradation functions with the generation of antigenic peptides for presentation by class I and class II MHC molecules to CD8 and CD4 T cells, respectively. Understanding the host and bacterial factors that affect phagosomal antigen processing may help facilitate new strategies to eliminate pathogens.
authors.affiliation: Department of Pathology, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Lakshmi
authors.initials: L
authors.lastname: Ramachandra
authors.forename: Daimon
authors.initials: D
authors.lastname: Simmons
authors.forename: Clifford V
authors.initials: CV
authors.lastname: Harding
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology* / Q000378:metabolism; D001424:Bacterial Infections / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D045142:Cross-Priming / Q000235:genetics; D006649:Histocompatibility Antigens / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D016056:Immunodominant Epitopes / Q000276:immunology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D010455:Peptides / Q000276:immunology; D010588:Phagosomes / Q000201:enzymology / Q000276:immunology* / Q000382:microbiology; D015398:Signal Transduction; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D000942:Antigens, Bacterial; D006649:Histocompatibility Antigens; D016056:Immunodominant Epitopes; D008562:Membrane Glycoproteins; D010455:Peptides; D051193:Toll-Like Receptors; C056558:CYBB protein, human; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases