Hypothermia after acute ischemic stroke.
Induced hypothermia after ischemic stroke is a promising neuroprotective therapy and is the most potent in pre-clinical models. Technological limitations and homeostatic mechanisms that maintain core body temperature, however, have limited the clinical application of hypothermia. Advances in intravascular cooling and successful trials of hypothermia after global cerebral ischemia, such as in cardiac arrest and neonatal asphyxia, have renewed interest in hypothermia for stroke.
Hemmen
Thomas M
TM
Department of Neuroscience, University of California, San Diego, California 92103-8466, USA. themmen@ucsd.edu
Lyden
Patrick D
PD
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods* / Q000639:trends; D020127:Recovery of Function / Q000502:physiology; D020521:Stroke / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D016896:Treatment Outcome