title: Synthesis of orthogonally protected azahistidine: application to the synthesis of a GHK analogue.
abstract: The synthesis of various orthogonally protected azahistidine derivatives are obtained via 1,3-dipolar cycloaddition reactions. The newly obtained amino-acids can be selectively deprotected either at the side chain or at the N-terminus of the amino acid and should thus allow the use of these derivatives in (solid phase) peptide synthesis.
authors.affiliation: CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage, 91191, Gif sur Yvette Cedex, France.
authors.forename: Stéphane
authors.initials: S
authors.lastname: Roux
authors.forename: Melinda
authors.initials: M
authors.lastname: Ligeti
authors.forename: David-Alexandre
authors.initials: DA
authors.lastname: Buisson
authors.forename: Bernard
authors.initials: B
authors.lastname: Rousseau
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Cintrat
mesh_terms: D000409:Alanine / Q000737:chemistry; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006639:Histidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
chemical_list: D001372:Aza Compounds; D006639:Histidine; D000409:Alanine