Biology of the eosinophil.
In this review, we aim to put in perspective the biology of a multifunctional leukocyte, the eosinophil, by placing it in the context of innate and adaptive immune responses. Eosinophils have a unique contribution in initiating inflammatory and adaptive responses, due to their bidirectional interactions with dendritic cells and T cells, as well as their large panel of secreted cytokines and soluble mediators. The mechanisms and consequences of eosinophil responses in experimental inflammatory models and human diseases are discussed.
Blanchard
Carine
C
Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229-3039, USA.
Rothenberg
Marc E
ME
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D047150:Eosinophil Cationic Protein / Q000276:immunology / Q000378:metabolism; D047093:Eosinophil Major Basic Protein / Q000276:immunology / Q000378:metabolism; D047208:Eosinophil-Derived Neurotoxin / Q000276:immunology / Q000378:metabolism; D004804:Eosinophils / Q000276:immunology* / Q000502:physiology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000378:metabolism; D016023:Integrins / Q000276:immunology / Q000378:metabolism; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology / Q000378:metabolism; D016177:Macrophage-1 Antigen / Q000276:immunology / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D009195:Peroxidase / Q000276:immunology / Q000378:metabolism
D015815:Cell Adhesion Molecules; D016207:Cytokines; D016023:Integrins; D016169:Lymphocyte Function-Associated Antigen-1; D016177:Macrophage-1 Antigen; C071777:integrin alpha4beta7; D009195:Peroxidase; D047208:Eosinophil-Derived Neurotoxin; D047150:Eosinophil Cationic Protein; D047093:Eosinophil Major Basic Protein