title: [Influence of Qingxiang San on substance P, somatostatin in rats model with the spleen and stomach wet heat syndrome].
abstract: OBJECTIVE
  To observe the influence of Qingxiang San (QS) on substance P (SP), somatostatin (SS) in rats model of spleen and stomach wet heat syndrome.
  
  
  METHODS
  24 rats were divided into 3 groups (each group 8 rats) randomly: the normal control group (NCG), wet heat group (WHG), QS group (QSG). We set up the spleen and stomach wet heat syndrome of rats model by the composite factors such as greasy and sweet food, wet and hot environment, pathogen and so on. Then the contents of SP, SS were detected by radioimmuno assay.
  
  
  RESULTS
  The content of SP, SS in WHG were obviously lower than NCG (P<0.01); QSG compared with WHG, the content of SP, SS increased (P<0.01); The content of SP obviously increased when QSG compared with NCG (P<0.01); About the content of SS, there was no significant difference between QSG and NCG (P>0.05), illustrating that QS can increase the content of SP, SS which had decreased.
  
  
  CONCLUSIONS
  QS can regulate the content of SP and SS and increase them which had decreased.
authors.affiliation: College of TCM, Southern Medical University, Guangzhou 510515, China.
authors.forename: Yong-Zhen
authors.initials: YZ
authors.lastname: Tan
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Wen
authors.forename: Pei-Chan
authors.initials: PC
authors.lastname: Chen
authors.forename: Yu-Jing
authors.initials: YJ
authors.lastname: Li
authors.forename: Pei-Hong
authors.initials: PH
authors.lastname: Chen
authors.forename: Gui-Qiong
authors.initials: GQ
authors.lastname: Huang
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D005768:Gastrointestinal Hormones / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D011706:Pyloric Antrum / Q000187:drug effects / Q000378:metabolism; D011863:Radioimmunoassay; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000378:metabolism*; D013158:Splenic Diseases / Q000188:drug therapy / Q000378:metabolism*; D013272:Stomach Diseases / Q000188:drug therapy / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D016710:Yin Deficiency / Q000188:drug therapy / Q000378:metabolism
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D005768:Gastrointestinal Hormones; D013373:Substance P; D013004:Somatostatin