[Acid-base state of blood in pregnant rats after application of lead acetate].
It was shown that the increase of lead content in the blood, liver, placenta of female rats, rat embryo and embryo's liver (by 80.4; 30.9; 26.8; 18.2 and 22.7%, respectively) of rats poisoned by lead causes pH decrease in blood, reduction of HCO3- concentration, content of general CO2, level of pCO2 and pO2, that evidences for development of subcompensated metabolic acidosis. It was determined, that the poisoning of pregnant rats causes deep metabolic acidosis and hypoxia in their organisms that can result in the prenatal death of fetus.
Tkachenko
T A
TA
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000138:Acidosis / Q000097:blood / Q000209:etiology / Q000378:metabolism; D000818:Animals; D001784:Blood Gas Analysis; D005260:Female; D000860:Hypoxia / Q000097:blood / Q000209:etiology / Q000378:metabolism; D007855:Lead Poisoning / Q000097:blood* / Q000150:complications / Q000378:metabolism; D008099:Liver / Q000196:embryology / Q000378:metabolism; D009942:Organometallic Compounds / Q000097:blood* / Q000493:pharmacokinetics / Q000506:poisoning; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood* / Q000378:metabolism; D051381:Rats
D009942:Organometallic Compounds; C008261:lead acetate