title: The atonal proneural transcription factor links differentiation and tumor formation in Drosophila.
abstract: The acquisition of terminal cell fate and onset of differentiation are instructed by cell type-specific master control genes. Loss of differentiation is frequently observed during cancer progression, but the underlying causes and mechanisms remain poorly understood. We tested the hypothesis that master regulators of differentiation may be key regulators of tumor formation. Using loss- and gain-of-function analyses in Drosophila, we describe a critical anti-oncogenic function for the atonal transcription factor in the fly retina, where atonal instructs tissue differentiation. In the tumor context, atonal acts by regulating cell proliferation and death via the JNK stress response pathway. Combined with evidence that atonal's mammalian homolog, ATOH1, is a tumor suppressor gene, our data support a critical, evolutionarily conserved, function for ato in oncogenesis.
authors.affiliation: Laboratory of Neurogenetics, Department of Molecular and Developmental Genetics, VIB, Leuven, Belgium.
authors.forename: Wouter
authors.initials: W
authors.lastname: Bossuyt
authors.forename: Natalie
authors.initials: N
authors.lastname: De Geest
authors.forename: Stein
authors.initials: S
authors.lastname: Aerts
authors.forename: Iris
authors.initials: I
authors.lastname: Leenaerts
authors.forename: Peter
authors.initials: P
authors.lastname: Marynen
authors.forename: Bassem A
authors.initials: BA
authors.lastname: Hassan
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics* / Q000378:metabolism; D019521:Body Patterning / Q000235:genetics; D002454:Cell Differentiation / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D005134:Eye Neoplasms / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D015972:Gene Expression Regulation, Neoplastic; D020868:Gene Silencing; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism; D030781:Organisms, Genetically Modified; D012160:Retina / Q000166:cytology / Q000196:embryology
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; C082142:ato protein, Drosophila