title: Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
abstract: Lycojapodine A, a novel C(16)N-type Lycopodium alkaloid with an unprecedented 6/6/6/7 tetracyclic ring system, was isolated from the club moss Lycopodium japonicum. The structure and relative stereochemistry were elucidated on the basis of spectroscopic data and were further confirmed by X-ray analysis. A possible biosynthetic pathway for 1 was proposed. Its inhibitory activity on acetylcholinestrease and anti-HIV-1 activity were also evaluated.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: He
authors.forename: Xuan-Qin
authors.initials: XQ
authors.lastname: Chen
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Xiao
authors.initials: X
authors.lastname: Cheng
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Peng
authors.forename: Min-Jin
authors.initials: MJ
authors.lastname: Xie
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D032502:Lycopodium / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000494:pharmacology
chemical_list: D000470:Alkaloids; D019380:Anti-HIV Agents; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C539671:lycojapodine A; C050426:huperzine A