title: [Chorionic villus cell culture and karyotype analysis in 110 cases of early spontaneous abortion].
abstract: OBJECTIVE
  To investigate the value of fetal chromosomal karyotype analysis in cases of early spontaneous abortion.
  
  
  METHODS
  Chorionic villus specimens obtained from 110 cases of early spontaneous abortion were cultured for karyotype analysis.
  
  
  RESULTS
  Of the 110 cases, chorionic villus was successfully cultured in 103 cases (93.7%), and abnormal embryo karyotypes were identified in 52 cases (50.5%). Trisomy was the most frequent embryo karyotype abnormalities in these cases, and chromosomal aberration occurred in 29 cases (52.9%) of the first spontaneous abortion and in 23 cases (42.6%) of repeated abortions. Female fetuses accounted for 75.5% (78 cases) in the spontaneously aborted fetuses and for 67.3% (35 cases) in fetuses with chromosomal abnormalities.
  
  
  CONCLUSIONS
  Embryo chromosomal abnormality is the most important reason of early spontaneous abortion, and karyotype analysis of the villus helps identify the causes of abortion and ensure the success of the next pregnancy.
authors.affiliation: Basic Medical Experiment Teaching Center, Southern Medical University, Guangzhou 510515, China.
authors.forename: Li
authors.initials: L
authors.lastname: Xiong
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Kang
authors.initials: K
authors.lastname: Deng
authors.forename: Si-ping
authors.initials: SP
authors.lastname: Liu
authors.forename: Bei
authors.initials: B
authors.lastname: Jia
authors.forename: Rui-feng
authors.initials: RF
authors.lastname: Wu
authors.forename: Mei
authors.initials: M
authors.lastname: Zhong
authors.forename: Rong
authors.initials: R
authors.lastname: Zeng
mesh_terms: D000022:Abortion, Spontaneous / Q000235:genetics* / Q000473:pathology*; D000328:Adult; D002478:Cells, Cultured; D002824:Chorionic Villi / Q000473:pathology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D014314:Trisomy / Q000235:genetics