title: Extensively drug-resistant tuberculosis: a case report and literature review.
abstract: Extensively drug-resistant tuberculosis (XDR-TB) is an emerging health problem that threatens tuberculosis (TB) control worldwide, since suitable treatment for this disease has not yet been found. We report a case of secondary pulmonary XDR-TB in a 54-year-old, HIV-negative male from Goiânia, Brazil. The patient had long-standing pulmonary tuberculosis (nine years) with extensive bilateral lung damage and had been treated with multiple antituberculosis drugs (self-administered) before XDR-TB diagnosis. The strain of Mycobacterium tuberculosis was resistant to R- rifampicin, H-isoniazid, E-ethambutol, Eto-ethionamide, Ofx-ofloxacin, and Am-amikacin. This patient died with multiple organ failure due to sepsis secondary to bacterial pneumonia.
authors.affiliation: Institute of Tropical Pathology and Public Health, Federal University of Goiás, GO, Brazil. araujofilho63@click21.com.br
authors.forename: João Alves de
authors.initials: JA
authors.lastname: Araújo-Filho
authors.forename: Arioldo Carvalho
authors.initials: AC
authors.lastname: Vasconcelos
authors.forename: Eduardo Martins de
authors.initials: EM
authors.lastname: Sousa
authors.forename: Colombina da
authors.initials: Cd
authors.lastname: Silveira
authors.forename: Elisangela
authors.initials: E
authors.lastname: Ribeiro
authors.forename: André
authors.initials: A
authors.lastname: Kipnis
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Junqueira-Kipnis
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D054908:Extensively Drug-Resistant Tuberculosis / Q000175:diagnosis* / Q000188:drug therapy; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000302:isolation & purification*; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents