Candidate selection and organ allocation in liver transplantation.
Optimal candidate selection and organ allocation should offer liver transplantation to those who are sufficiently sick to justify the procedure but not too sick to benefit from it, in an order determined by patients' projected survival benefit, matching organs of sufficiently good quality to the appropriate recipients. Significant steps have been made in recent years toward devising selection and allocation criteria based on more objective and evidence-based definitions of candidate disease severity, transplant futility, organ quality, and appropriate donor-recipient matching. However, much work remains to be done in the future.
Dawwas
Muhammad F
MF
Liver Transplant Unit, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Gimson
Alexander E
AE
D006528:Carcinoma, Hepatocellular / Q000601:surgery; D006297:Health Services Accessibility; D006648:Histocompatibility; D006801:Humans; D008107:Liver Diseases / Q000601:surgery*; D017093:Liver Failure / Q000601:surgery; D008113:Liver Neoplasms / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects / Q000941:ethics; D018579:Patient Selection / Q000941:ethics; D018570:Risk Assessment; D012720:Severity of Illness Index; D014019:Tissue Donors / Q000941:ethics / Q000600:supply & distribution*; D009927:Tissue and Organ Procurement / Q000941:ethics / Q000458:organization & administration*; D016896:Treatment Outcome; D006113:United Kingdom; D014481:United States; D014850:Waiting Lists