title: The synthesis of analogs of shuangkangsu, a novel natural cycloperoxide glucoside from Lonicera japonica Thunb.
abstract: Four novel optically pure cycloperoxide glucosides 9a, 9b, 10a, and 10b, analogs of shuangkangsu--a natural product with unusual skeleton and antivirus activity from the buds of Lonicera japonica Thunb, were firstly synthesized by employing peroxidation and glucosidation reactions from phthalaldehyde or 4,5-dichloro phthalaldehyde and glucose.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Peking Union Medical College, Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Tang
authors.forename: Long-Jiang
authors.initials: LJ
authors.lastname: Huang
authors.forename: Di-Zao
authors.initials: DZ
authors.lastname: Li
authors.forename: Qing-Jian
authors.initials: QJ
authors.lastname: Zhang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004146:Dioxanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005947:Glucose / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031239:Lonicera / Q000737:chemistry*; D015394:Molecular Structure; D009005:Monosaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D009764:o-Phthalaldehyde / Q000737:chemistry
chemical_list: C539038:5,8-divinyl-1,4-dihydro-1,4-di-O-beta-D-glucopyranosyl-2,3-dioxane; D000998:Antiviral Agents; D004146:Dioxanes; D005960:Glucosides; D009005:Monosaccharides; D009764:o-Phthalaldehyde; D005947:Glucose