title: The novel ischemia marker 'ischemia-modified albumin' is increased in normal pregnancies.
abstract: The aim of this prospective case-control study was to determine the change in serum maternal ischemia-modified albumin (IMA) during normal pregnancies. A total of 117 pregnant (first trimester (n=24), second trimester (n=34), and third trimester (n=35)) and non-pregnant healthy women (n=23) were included. Maternal serum IMA, Malondialdehyde (MDA), and albumin levels were measured. Compared with non-pregnant women, the cross-sectional mean IMA levels in pregnant women were significantly increased, while the mean serum MDA and albumin levels were significantly decreased throughout pregnancy. Furthermore, a significant negative correlation between serum IMA and albumin levels (r=-0.354, p<0.001) was found, and there was a weak positive correlation between serum albumin and MDA levels (r=0.334, p<0.001). Serum IMA, which has recently been developed as a clinical marker of ongoing myocardial ischemia, appears to be elevated in normal pregnancy. This may be due to the physiologic oxidative stress state of pregnancy.
authors.affiliation: Department of Obstetric and Gynecology, Karadeniz Technical University, Trabzon, Turkey. drsuleymanguven@yahoo.com
authors.forename: Suleyman
authors.initials: S
authors.lastname: Guven
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alver
authors.forename: Ahmet
authors.initials: A
authors.lastname: Mentese
authors.forename: F Ceylan
authors.initials: FC
authors.lastname: Ilhan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Calapoglu
authors.forename: Mesut A
authors.initials: MA
authors.lastname: Unsal
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007511:Ischemia / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D011247:Pregnancy / Q000097:blood* / Q000502:physiology; D011446:Prospective Studies; D012709:Serum Albumin / Q000032:analysis* / Q000096:biosynthesis*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; D008315:Malondialdehyde