Why are tumour blood vessels abnormal and why is it important to know?
Tumour blood vessels differ from their normal counterparts for reasons that have received little attention. We report here that they are of at least six distinct types, we describe how each forms, and, looking forward, encourage the targeting of tumour vessel subsets that have lost their vascular endothelial growth factor-A (VEGF-A) dependency and so are likely unresponsive to anti-VEGF-A therapies.
Nagy
J A
JA
Center for Vascular Biology Research, Beth Israel Deaconess Medical Center and Harvard Medical School, Baston, Massachusetts 02215, USA.
Chang
S-H
SH
Dvorak
A M
AM
Dvorak
H F
HF
D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D002196:Capillaries / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000502:physiology
D042461:Vascular Endothelial Growth Factor A