title: Assembly of substituted 3-methyleneisoindolin-1-ones via a CuI/l-proline-catalyzed domino reaction process of 2-bromobenzamides and terminal alkynes.
abstract: CuI/l-proline catalyzed coupling of 2-bromobenzamides and terminal alkynes in i-PrOH (or DMF and DMSO) at 85-110 degrees C and subsequent additive cyclization produces substituted 3-methyleneisoindolin-1-ones. Variation of N-substituents, aromatic ring, and methylene part is possible by using suitable starting materials.
authors.affiliation: Shenyang Pharmaceutical University, 103 Wenhua Lu, Shenyang 110016, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Zhang
authors.forename: Yongwen
authors.initials: Y
authors.lastname: Jiang
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001549:Benzamides / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001549:Benzamides; D007211:Indoles; D003300:Copper; D011392:Proline