Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution.
BACKGROUND
Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.


RESULTS
We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.
Nilsson
Björn
B
Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. bnilsson@broad.mit.edu
Johansson
Mikael
M
Al-Shahrour
Fatima
F
Carpenter
Anne E
AE
Ebert
Benjamin L
BL
D000465:Algorithms; D002869:Chromosome Aberrations; D019295:Computational Biology / Q000379:methods*; D018628:Gene Dosage; D020869:Gene Expression Profiling; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D020641:Polymorphism, Single Nucleotide