Exploration of cytotoxic effect of malathion on some rat organs structure.
Widespread use of insecticides has caused several risks to public health. This work was designed to investigate the histological changes in Liver, lung, adrenal medulla and testis of Wistar rats treated with malathion, administered intra peritoneally at a dose of 33,051 mg/kg per day. Exposure to the malathion, for 40 days, induced histological alterations: regular arrangement of hepatocytes with dilated sinusoidal spaces, thickened Lung epithelium, regression of adrenal medulla with congestion and disruption of the germ Line. These alterations represent the signs of cytotoxicity of malathion in Wistar rats.
Saadi
L
L
Département de Biologie, Faculté des Sciences Agro-Vétérinaires Université Saad Dahleb de Blida, Algérie.
Lebaili
N
N
Benyoussi
M
M
D000313:Adrenal Medulla / Q000187:drug effects / Q000473:pathology; D000818:Animals; D007274:Injections, Intraperitoneal; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008294:Malathion / Q000633:toxicity*; D008297:Male; D009928:Organ Specificity; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013737:Testis / Q000187:drug effects / Q000473:pathology; D018675:Toxicity Tests
D007306:Insecticides; D008294:Malathion