title: [A case of elderly esophageal adenocarcinoma successfully treated with daily low-dose nedaplatin (CDGP) and continuous infusion of 5-FU combined with radiation].
abstract: We report an elderly patient with esophageal adenocarcinoma in whom a complete response (CR) was obtained by chemoradiotherapy using daily low-dose nedaplatin (CDGP) and continuous infusion of 5-FU. A 86-year-old man who had non-tuberculous mycobacterial infection was admitted for dysphagia, and diagnosed with Stage II A (T2N0M0) esophageal adenocarcinoma of the lower esophagus according to the TNM classification (sixth edition) of the International Union against Cancer (UICC). Chemoradiotherapy using daily low-dose CDGP and continuous infusion of 5- FU was performed, and thereafter one cycle of chemotherapy using CDGP and 5-FU was added. As the side effects of treatment, grade 3 leucopenia was observed while he was receiving chemoradiotherapy. A year later, he presented with grade 2 pericardial and pleural effusion and recovered with conservative treatment. CR was obtained and has been continued for two years. Definitive chemoradiotherapy using daily low-dose CDGP and continuous infusion of 5-FU is an effective choice for elderly and high-risk patients with esophageal adenocarcinoma.
authors.affiliation: First Dept. of Medicine, Hamamatsu University School of Medicine.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Osawa
authors.forename: Takanori
authors.initials: T
authors.lastname: Yamada
authors.forename: Moriya
authors.initials: M
authors.lastname: Iwaizumi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Hamaya
authors.forename: Kosuke
authors.initials: K
authors.lastname: Takagaki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Nishino
authors.forename: Chise
authors.initials: C
authors.lastname: Kodaira
authors.forename: Akiko
authors.initials: A
authors.lastname: Muramatsu
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Yoshida
authors.forename: Ken
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Futami
authors.forename: Takahisa
authors.initials: T
authors.lastname: Furuta
authors.forename: Mutsuhiro
authors.initials: M
authors.lastname: Ikuma
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D016099:Endoscopy, Gastrointestinal; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D011859:Radiography
chemical_list: D009944:Organoplatinum Compounds; C053989:nedaplatin; D005472:Fluorouracil