title: Antimicrobial resistance of Campylobacter: prevalence and trends in Japan.
abstract: Campylobacter is one of the most frequently diagnosed bacterial causes of human gastroenteritis in Japan and throughout the world. Resistance to quinolones in Campylobacter jejuni and C. coli isolated from humans has emerged in many countries during the past 15 years because fluoroquinolones are the drug of choice for the treatment of suspected bacterial gastroenteritis. Food contaminated with Campylobacter is the usual source of human infection; therefore, the presence of antimicrobial resistance strains in the food chain has raised concerns that the treatment of human infections will be compromised. The use of antimicrobial agents for food animals and in veterinary medicine is suspected to be correlated with an increase in quinolone-resistant strains of Campylobacter in food animals, especially in poultry products. In contrast to macrolide resistance in C. jejuni and C. coli isolated from humans showing a stable low rate, resistant Campylobacter spp. to quinolones have emerged in Japan. The paper summarizes food-borne Campylobacter infection in Japan, and the prevalence and trends of antimicrobial resistance of Campylobacter from the authors' data and other Japanese papers which reported the antimicrobial resistance of Campylobacter.
authors.affiliation: National Institute of Health Sciences, Tokyo, Japan. igimi@nihs.go.jp
authors.forename: S
authors.initials: S
authors.lastname: Igimi
authors.forename: Y
authors.initials: Y
authors.lastname: Okada
authors.forename: A
authors.initials: A
authors.lastname: Ishiwa
authors.forename: M
authors.initials: M
authors.lastname: Yamasaki
authors.forename: N
authors.initials: N
authors.lastname: Morisaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kubo
authors.forename: H
authors.initials: H
authors.lastname: Asakura
authors.forename: S
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D002169:Campylobacter Infections / Q000453:epidemiology / Q000382:microbiology*; D017000:Campylobacter coli / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D016123:Campylobacter jejuni / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D004350:Drug Residues; D024881:Drug Resistance, Bacterial; D004751:Enteritis / Q000453:epidemiology / Q000382:microbiology; D005516:Food Microbiology; D005517:Foodborne Diseases / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D015995:Prevalence