Regulatory noncoding RNAs at Hox loci.
There is growing awareness of the importance of noncoding (nc)RNAs in the regulation of gene expression during pattern formation in development. Spatial regulation of Hox gene expression in development controls positional identity along the antero-posterior axis. In this review, we will focus on the role of short ncRNAs that repress Hox genes in Drosophila and mammals by RNA interference (RNAi), on long ncRNAs that may repress a Hox in cis in Drosophila by transcriptional interference, and on a novel long ncRNA that functions in trans to regulate Hox genes mammals.
Brock
Hugh W
HW
Molecular Epigenetics Group, Life Sciences Institute, University of British Columbia, Vancouver, BCV6T1Z3, Canada. brock@zoology.ubc.ca
Hodgson
Jacob W
JW
Petruk
Svetlana
S
Mazo
Alexander
A
D000818:Animals; D004330:Drosophila / Q000235:genetics; D005801:Genes, Homeobox; D008322:Mammals / Q000235:genetics; D035683:MicroRNAs / Q000235:genetics; D005810:Multigene Family; D022661:RNA, Untranslated / Q000235:genetics*
D035683:MicroRNAs; D022661:RNA, Untranslated