title: Association of antiphosphatidylserine/prothrombin antibodies with neuropsychiatric systemic lupus erythematosus.
abstract: Neuropsychiatric manifestations in patients with systemic lupus erythematosus (SLE) are well-recognized symptoms although the pathophysiology of neuropsychiatric SLE (NPSLE) is unclear. Since an association with antiphospholipid antibodies has been reported, we examined the prevalence of antiphosphatidylserine-prothrombin antibodies (anti-PS/PT Abs), lupus anticoagulant (LA), anticardiolipin/beta2-glycoprotein I antibodies (anti-beta2-GPI Abs), and antiribosomal P protein antibodies (antiribosomal P Abs) in 68 SLE patients and analyzed their associations with neuropsychiatric manifestations. The prevalence of LA was significantly higher in the patients with neuropsychiatric (NP) features than those without NP features (P < 0.02). The levels of anti-PS/PT antibody were also significantly higher in the patients with NP features than those without NP features (P < 0.01). The results indicate that LA positivity and higher levels of anti-PS/PT antibody can be predictive markers for NPSLE.
authors.affiliation: Department of Dermatology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan. tomot@showa.gunma-u.ac.jp
authors.forename: Tomoko
authors.initials: T
authors.lastname: Syuto
authors.forename: Akira
authors.initials: A
authors.lastname: Shimizu
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Setsuko
authors.initials: S
authors.lastname: Tanaka
authors.forename: Michiko
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Nagai
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tamura
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
mesh_terms: D017153:Antibodies, Anticardiolipin / Q000097:blood; D017152:Antibodies, Antiphospholipid / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D020945:Lupus Vasculitis, Central Nervous System / Q000150:complications / Q000276:immunology* / Q000473:pathology; D010718:Phosphatidylserines / Q000276:immunology*; D011237:Predictive Value of Tests; D011516:Prothrombin / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology; D053482:beta 2-Glycoprotein I / Q000276:immunology
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid; D001323:Autoantibodies; D016682:Lupus Coagulation Inhibitor; D010718:Phosphatidylserines; D012269:Ribosomal Proteins; D053482:beta 2-Glycoprotein I; D011516:Prothrombin