title: Synthesis and conformational analysis of cyclotetrapeptide mimetic beta-turn templates and validation as 3D scaffolds.
abstract: The conformations of all stereoisomers of PMRI cyclotetrapeptide mimetics 1-8 are essentially determined by the predisposition of the diamine to stabilize beta-turns. The peptide mimetics can be regarded as 3D scaffolds for designing molecules with a predictable display of the pharmacophores. We used the models for testing novel RGD analogues as alpha(v)beta(3)-integrin receptor antagonists.
authors.affiliation: Department of Chemistry "G. Ciamician", University of Bologna, Italy. gentilucci@unibo.it
authors.forename: Luca
authors.initials: L
authors.lastname: Gentilucci
authors.forename: Giuliana
authors.initials: G
authors.lastname: Cardillo
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tolomelli
authors.forename: Rossella
authors.initials: R
authors.lastname: De Marco
authors.forename: Andrea
authors.initials: A
authors.lastname: Garelli
authors.forename: Santi
authors.initials: S
authors.lastname: Spampinato
authors.forename: Antonino
authors.initials: A
authors.lastname: Spartà
authors.forename: Eusebio
authors.initials: E
authors.lastname: Juaristi
mesh_terms: D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D045744:Cell Line, Tumor; D003198:Computer Simulation; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D039302:Integrin alphaVbeta3 / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000737:chemistry*
chemical_list: D039302:Integrin alphaVbeta3; D010456:Peptides, Cyclic