title: Plasma calcitonin gene-related peptide in diagnosing and predicting paediatric migraine.
abstract: To investigate the role of plasma calcitonin gene-related peptide (CGRP) in paediatric migraine, we prospectively collected 134 blood samples during or between attacks from 66 migraine, 33 non-migraine headache (non-migraine) and 22 non-headache patients, aged 4-18 years. Plasma CGRP concentrations were measured by enzyme-linked immunosorbent assay and disability by Pediatric MIgraine Disability ASsessment (PedMIDAS) questionnaire. Migraineurs had higher plasma CGRP levels than non-migraine patients (P = 0.007). The attack level was higher than the non-attack level in migraine (P = 0.036), but not in non-migraine, patients. This was also revealed in paired comparison (n = 9, P = 0.015 vs. n = 4, P = 0.47). Using a threshold of 55.1 pg/ml, the sensitivity of the attack level in predicting migraine was 0.81, and specificity 0.75. The PedMIDAS score tended to be higher in the high CGRP (> 200 pg/ml, n = 7) group than in the low (< 200 pg/ml, n = 33) group (26.07 vs. 19.32, P = 0.16) using Mann-Whitney test. Plasma CGRP is useful for diagnosis in paediatric migraine.
authors.affiliation: Department of Paediatrics, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: P-C
authors.initials: PC
authors.lastname: Fan
authors.forename: P-H
authors.initials: PH
authors.lastname: Kuo
authors.forename: S-H
authors.initials: SH
authors.lastname: Chang
authors.forename: W-T
authors.initials: WT
authors.lastname: Lee
authors.forename: R-M
authors.initials: RM
authors.lastname: Wu
authors.forename: L-C
authors.initials: LC
authors.lastname: Chiou
mesh_terms: D000293:Adolescent; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood* / Q000175:diagnosis*; D010372:Pediatrics / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D015740:Calcitonin Gene-Related Peptide