Nosocomial spread of linezolid-resistant Staphylococcus haemolyticus infections in an intensive care unit.
This report documents the nosocomial spread for an 18-month period of a single clone of linezolid- and teicoplanin-resistant Staphylococcus haemolyticus associated primarily with catheter-related bacteremia in intensive care unit patients. All linezolid-resistant isolates had the same G2576T mutation in at least 1 copy of the 23S rRNA gene.
Rodríguez-Aranda
Almudena
A
Servicio de Microbiología Clínica, Hospital Universitario 12 de Octubre, Madrid, Spain.
Daskalaki
Maria
M
Villar
Julia
J
Sanz
Francisca
F
Otero
Joaquín R
JR
Chaves
Fernando
F
D000081:Acetamides / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016470:Bacteremia / Q000453:epidemiology / Q000382:microbiology; D002404:Catheterization / Q000009:adverse effects; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D024881:Drug Resistance, Bacterial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D000069349:Linezolid; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D023303:Oxazolidinones / Q000494:pharmacology*; D017354:Point Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D041162:Staphylococcus haemolyticus / Q000187:drug effects* / Q000302:isolation & purification*; D017334:Teicoplanin / Q000494:pharmacology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D012338:RNA, Ribosomal, 23S; D017334:Teicoplanin; D000069349:Linezolid