Blood lymphocyte proliferation reaction in autoimmune thyropathies.
Spontaneous and stimulated reaction of lymphocyte proliferation and blood levels of CD25- and CD120-expressing lymphocytes were studied in patients with autoimmune thyroiditis and diffuse toxic goiter. Activation of CD25- and CD120-presenting function of blood lymphocytes was revealed. The findings indicate that the course of autoimmune thyroiditis and diffuse toxic goiter is associated with increased levels of basal, mitogen- and cytokine-stimulated proliferation of blood lymphocytes, particularly pronounced in thyroiditis in the euthyrosis stage.
Urazova
O I
OI
Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia.
Kravets
E B
EB
Nedosekova
Yu V
YV
Rogaleva
A V
AV
Kuznecova
V N
VN
Rumpel
O A
OA
D000328:Adult; D006042:Goiter / Q000097:blood*; D006111:Graves Disease / Q000097:blood; D006801:Humans; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology*; D008875:Middle Aged; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism; D013967:Thyroiditis, Autoimmune / Q000097:blood*
D053645:Interleukin-2 Receptor alpha Subunit; D018124:Receptors, Tumor Necrosis Factor