title: Action potential characteristics in the sinus venosa of patients with and without atrial flutter.
abstract: BACKGROUND
  A functional line of conduction block is often observed in the sinus venosa (SV) during typical atrial flutter (AFL). Little information, however, is available as to the action potential characteristics in the SV with respect to the functional block.
  
  
  RESULTS
  Monophasic action potentials (MAPs) from the SV and lateral wall of the right atrium were recorded in 7 patients with paroxysmal AFL and 11 control patients. For both the control and AFL patients, the MAP duration at 90% repolarization (MAPD90) in the SV was longer, and the MAPD90 restitution slope was less steep than in the lateral wall. The MAPD90 in the SV in the AFL patients was slightly longer than that in the controls at the shortest cycle length (CL) tested (300 ms). However, the MAPD90s at longer CLs (350-700 ms), as well as the MAPD90 restitution slopes in the SV were comparable between the 2 groups.
  
  
  CONCLUSIONS
  The MAPs in the SV are characterized by a long duration and flat restitution kinetics in humans. MAP properties to facilitate the development of conduction block in the SV are not appreciable in patients with paroxysmal typical AFL.
authors.affiliation: Division of Arrhythmia and Electrophysiology, Shizuoka Saiseikai General Hospital, Shizuoka, Japan.
authors.forename: Masahide
authors.initials: M
authors.lastname: Harada
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Osaka
authors.forename: Eriko
authors.initials: E
authors.lastname: Yokoyama
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ito
authors.forename: Itsuo
authors.initials: I
authors.lastname: Kodama
mesh_terms: D000200:Action Potentials; D000328:Adult; D000368:Aged; D001282:Atrial Flutter / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged