title: Dissemination of a bla(VIM-2)-carrying integron among Enterobacteriaceae species in Mexico: report from the SENTRY Antimicrobial Surveillance Program.
abstract: Three VIM-2-producing Enterobacteriaceae (two Enterobacter cloacae and one Klebsiella oxytoca) isolates recovered from patients in a Mexican hospital were characterized during the SENTRY Antimicrobial Surveillance Program (2005-2007). These strains carried identical bla(VIM-2) integrons in a 450-kb plasmid. The interspecies dissemination of this bla(VIM-2)-harboring element emphasizes the potential for spread of genetic structures carrying metallo-beta-lactamases that could limit therapeutic options in this geographic region.
authors.affiliation: Instituto de Pathologia Infecciosa y Experimental, Centro Universitario Ciencias de la Salud, Universidad de Guadalajara, Guadalajara, Mexico.
authors.forename: Rayo
authors.initials: R
authors.lastname: Morfin-Otero
authors.forename: Eduardo
authors.initials: E
authors.lastname: Rodriguez-Noriega
authors.forename: Lalitagauri M
authors.initials: LM
authors.lastname: Deshpande
authors.forename: Helio S
authors.initials: HS
authors.lastname: Sader
authors.forename: Mariana
authors.initials: M
authors.lastname: Castanheira
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004269:DNA, Bacterial / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D016972:Enterobacter cloacae / Q000187:drug effects / Q000235:genetics; D004755:Enterobacteriaceae / Q000187:drug effects / Q000235:genetics*; D004756:Enterobacteriaceae Infections / Q000235:genetics* / Q000382:microbiology*; D005798:Genes, Bacterial / Q000235:genetics; D006761:Hospitals; D006801:Humans; D032023:Integrons / Q000235:genetics; D041121:Klebsiella oxytoca / Q000187:drug effects / Q000235:genetics; D008800:Mexico / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D010957:Plasmids / Q000235:genetics; D011159:Population Surveillance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases