[Drug-resistant pulmonary tuberculosis at the penitentiaries].
In recent years, the penitentiaries of Russia have tended to show some stabilization of some tuberculosis indices. In 2006, its morbidity and mortality versus 1999 decreased by 3 times and amounted to 1387 and 79 per 100,000, respectively. The spread of its drug-resistant forms has a considerable impact on the deterioration of the tuberculosis epidemic situation. At present the number of patients with primary drug resistance of the total number of bacterial-discharging persons is more than 50%; multidrug resistance is observed in more than 20% of cases. The use of chemotherapy regimen IIb using fluoroquinolones in the intensive-phase chemotherapy in the treatment of destructive pulmonary tuberculosis allowed Mycobacterium tuberculosis polyresistance to isoniazid and rifampicin in combination with other first-line antituberculous agents and multidrug resistance to be overcome in 87 and 79.5% of cases, respectively.
Kononets
A S
AS
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D004977:Ethambutol / Q000008:administration & dosage / Q000627:therapeutic use*; D024841:Fluoroquinolones / Q000627:therapeutic use; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000627:therapeutic use*; D011329:Prisoners; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*; D012426:Russia / Q000453:epidemiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000453:epidemiology / Q000401:mortality; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000453:epidemiology / Q000401:mortality
D000900:Anti-Bacterial Agents; D000904:Antibiotics, Antitubercular; D000995:Antitubercular Agents; D024841:Fluoroquinolones; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin