title: [Effect of continuous probiotic fermented milk intake containing Lactobacillus casei strain Shirota on fever in mass infectious gastroenteritis rest home outbreak].
abstract: As part of medical risk management in a long-term stay facility for the elderly, we introduced probiotic fermented milk containing Lactobacillus casei strain Shirota (LcS-fermented milk) in an open case-control study of its effect of (1 bottle a day) on winter-time norovirus gastroenteritis. During the 1 month from December 1 to 31, 2006, norovirus gastroenteritis occurred in 21 (55%) of 38 cases in the nonmilk group, and in 27 (64%) of 39 cases in the milk group, showing no statistically significant difference. The mean duration of >37 degrees C fever after disease onset, however, was 2.9+/-2.3 days in the non-milk group and 1.5+/-1.7 days in the milk group, showing significant shortening (p<0.05). The duration of > 38 degrees C fever after disease onset also tended to be shorter. No significant differences were seen in age, gender, days of antipyretic use, or stool-free days. These results suggested that continuous intake of LcS-fermented milk could aggravate fever duration in elderly long-term rest home residents although it probably did not prevent noroviral gastroenteritis onset.
authors.affiliation: Department of Laboratory for Probiotics Research, Juntendo University School of Medicine.
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Yamada
authors.forename: Satoru
authors.initials: S
authors.lastname: Nagata
authors.forename: Shigemi
authors.initials: S
authors.lastname: Kondo
authors.forename: Lei
authors.initials: L
authors.lastname: Bian
authors.forename: Chongxin
authors.initials: C
authors.lastname: Wang
authors.forename: Takashi
authors.initials: T
authors.lastname: Asahara
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Ohta
authors.forename: Koji
authors.initials: K
authors.lastname: Nomoto
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yamashiro
mesh_terms: D000369:Aged, 80 and over; D017250:Caliciviridae Infections / Q000503:physiopathology*; D016022:Case-Control Studies; D004196:Disease Outbreaks; D005260:Female; D005334:Fever / Q000503:physiopathology; D005759:Gastroenteritis / Q000503:physiopathology*; D006707:Homes for the Aged; D006801:Humans; D007780:Lacticaseibacillus casei; D008297:Male; D029322:Norovirus; D019936:Probiotics / Q000627:therapeutic use*; D012308:Risk Management