Mechanism of action of clinically approved adjuvants.
Aluminum-containing adjuvants continue to be the most widely used adjuvants for human use. In the last year a major breakthrough has been the realization that alum adjuvant triggers an ancient pathway of innate recognition of crystals in monocytes and triggers them to become immunogenic dendritic cells, nature's adjuvant. This recognition can occur directly, via the triggering of the NALP3 inflammasome by alum crystals, or indirectly through release of the endogenous danger signal uric acid. It is also clear now that adjuvants trigger the stromal cells at the site of injection, leading to the necessary chemokines that attract the innate immune cells to the site of injection. How exactly these pathways interact remains to be determined.
Lambrecht
Bart N
BN
Department of Respiratory Diseases, University of Ghent, De Pintelaan, Belgium. bart.lambrecht@ugent.be
Kool
Mirjam
M
Willart
Monique A M
MA
Hammad
Hamida
H
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000378:metabolism*; D000534:Alum Compounds / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000276:immunology; D002454:Cell Differentiation; D016207:Cytokines / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007113:Immunity, Innate; D050866:Liquid Crystals / Q000737:chemistry; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D011136:Polysorbates; D012503:Saponins; D013185:Squalene; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism; D014527:Uric Acid / Q000276:immunology
D000276:Adjuvants, Immunologic; D000534:Alum Compounds; D002352:Carrier Proteins; D016207:Cytokines; C089950:MF59 oil emulsion; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D011136:Polysorbates; D012503:Saponins; D014527:Uric Acid; C078785:saponin QA-21V1; D013185:Squalene