title: Intermediate fixed coronary artery stenosis at the site of ergonovine-provoked spasm as a predictor of long-term major adverse cardiac events of patients with coronary spastic angina.
abstract: BACKGROUND
  Organic coronary artery stenosis is a significant prognostic factor in patients with coronary spastic angina (CSA), so the present study was focused on assessing the impact of intermediate fixed stenosis at sites of provoked spasm on the long-term outcomes of CSA patients.
  
  
  RESULTS
  CSA patients diagnosed on the basis of ergonovine-provoked spasm were enrolled and the clinical background and long-term prognosis of CSA patients with intermediate fixed stenosis at the site of provoked spasm (with-fixed-stenosis group, n=37) and those without fixed stenosis (without-fixed-stenosis group, n=126) were retrospectively compared. During the follow-up period (average 4.01 years for with-fixed-stenosis, 4.47 years for without-fixed-stenosis), the with-fixed-stenosis group had a significantly lower event-free survival rate, as well as a higher frequency of admission for unstable angina and percutaneous coronary intervention than the without-fixed-stenosis group, whereas the survival rate did not differ significantly between the 2 groups. In the multivariate analysis, intermediate fixed stenosis at the site of provoked spasm was a predictor of long-term major adverse cardiac events (MACE).
  
  
  CONCLUSIONS
  Intermediate fixed stenosis at the site of ergonovine-provoked spasm is an independent risk factor for MACE during the long-term period in CSA patients.
authors.affiliation: Department of Cardiovascular Medicine, Kyoto Prefectural University of Medicine, and Department of Cardiology, Kyoto First Red Cross Hospital, Kyoto, Japan. nshinya@koto.kpu-m.ac.jp
authors.forename: Shinya
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Jun
authors.initials: J
authors.lastname: Shiraishi
authors.forename: Sayuki
authors.initials: S
authors.lastname: Torii
authors.forename: Kotaro
authors.initials: K
authors.lastname: Miyagawa
authors.forename: Masayasu
authors.initials: M
authors.lastname: Arihara
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Hadase
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hyogo
authors.forename: Takakazu
authors.initials: T
authors.lastname: Yagi
authors.forename: Takatomo
authors.initials: T
authors.lastname: Shima
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kohno
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsubara
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000401:mortality*; D023921:Coronary Stenosis / Q000139:chemically induced / Q000401:mortality*; D003331:Coronary Vessels; D018572:Disease-Free Survival; D004874:Ergonovine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010120:Oxytocics / Q000008:administration & dosage / Q000009:adverse effects*; D012189:Retrospective Studies; D013035:Spasm / Q000139:chemically induced / Q000401:mortality*; D015996:Survival Rate
chemical_list: D010120:Oxytocics; D004874:Ergonovine