[Expression of TBX3 mRNA and its role in the pathogenesis and metastasis of breast cancer].
OBJECTIVE
To explore the role of TBX3 gene in the pathogenesis of breast cancer.


METHODS
The total RNA of 51 fresh breast cancer tissues and the corresponding adjacent tissues were extracted and reverse transcribed into cDNA to detect the expression of TBX3 mRNA by real-time PCR. The correlation between TBX3 mRNA expression and the clinicopathologic parameters in relation to breast cancer metastasis was analyzed.


RESULTS
Compared to that in the adjacent tissues, the expression of TBX3 mRNA was markedly increased in breast cancer tissues. TBX3 mRNA expression was significantly higher in metastatic breast cancer than in non-metastatic tumors.


CONCLUSIONS
Increased expression of TBX3 mRNA suggests the involvement of TBX3 in the pathogenesis and metastasis of breast cancer.
Chen
Zhong-hua
ZH
Fuzhou General Hospital of Nanjing Command, Fuzhou 350025, China.
Lü
Guang-ming
GM
Ji
Tian-hai
TH
D001943:Breast Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology*; D005260:Female; D006801:Humans; D009362:Neoplasm Metastasis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020825:T-Box Domain Proteins / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D020825:T-Box Domain Proteins; C106884:TBX3 protein, human