Key role of macrophages in the pathogenesis of CD18 hypomorphic murine model of psoriasis.
Psoriasis is a chronic skin disorder of unsolved pathogenesis affecting skin in 2-3% of the general population. Research into the pathogenesis of psoriasis has profited from suitable animal models. Previously, we reported on the CD18 hypomorphic (CD18(hypo)) PL/J mouse model clinically resembling human psoriasis, which is characterized by reduced expression of the common chain of beta(2)-integrins (CD11/CD18) to only 2-16% of wild-type levels. Aside from common clinical and pathophysiological features shared with human psoriasis, the psoriasiform skin disease in CD18(hypo) PL/J mice also depends on the presence of CD4(+) T-cells. This review focuses on the role of activated macrophages in the pathogenesis of CD18(hypo) T-cell-mediated mouse model of psoriasis, and extends our understanding in unrestrained pathogenic T-cells whose activation may be crucial for the recruitment and activation of macrophages within skin. The findings in the CD18(hypo) PL/J model are discussed in the context of current literatures of human and other autoimmune disorders.
Wang
Honglin
H
Department of Dermatology and Allergic Diseases, University of Ulm, Ulm, Germany.
Peters
Thorsten
T
Sindrilaru
Anca
A
Scharffetter-Kochanek
Karin
K
D000818:Animals; D018821:CD18 Antigens / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D008264:Macrophages / Q000276:immunology / Q000473:pathology / Q000502:physiology*; D051379:Mice; D011565:Psoriasis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000378:metabolism
D018821:CD18 Antigens; D014409:Tumor Necrosis Factor-alpha