title: Feasibility of single-voxel MRS measurement of apparent diffusion coefficient of water in breast tumors.
abstract: We report initial results with single voxel spectroscopy (SVS) using diffusion weighting and localization by adiabatic selective refocusing (LASER) in breast tumors to measure the apparent diffusion coefficient of water (ADCw). This is a quick (30 s) and relatively easy method to implement compared with image-based diffusion measurements, and is insensitive to lipid signal contamination. The ADCw and concentration of total choline containing compounds [tCho] were evaluated for associations with each other and final pathologic diagnosis in 25 subjects. The average (+/- SD) ADCw in benign and malignant lesions was 1.96 +/- 0.47 mm(2)/s and 1.26 +/- 0.29 x 10(-3) mm(2)/s, respectively, P< 0.001. Receiver operating characteristic curve analysis showed an area under the curve of 0.92. Analysis of the single voxel (SV) ADCw and [tCho] showed significant correlation with a R(2) of 0.56, P< 0.001. Compared with more commonly used image-based methods of measuring water ADC, SV-ADCw is faster, more robust, insensitive to fat, and potentially easier to implement on standard clinical systems.
authors.affiliation: Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN 55455, USA. corum@cmrr.umn.edu
authors.forename: C A
authors.initials: CA
authors.lastname: Corum
authors.forename: A D
authors.initials: AD
authors.lastname: McIntosh
authors.forename: P J
authors.initials: PJ
authors.lastname: Bolan
authors.forename: M
authors.initials: M
authors.lastname: Nelson
authors.forename: A L
authors.initials: AL
authors.lastname: Snyder
authors.forename: N J
authors.initials: NJ
authors.lastname: Powell
authors.forename: J
authors.initials: J
authors.lastname: Boyum
authors.forename: T H
authors.initials: TH
authors.lastname: Emory
authors.forename: D
authors.initials: D
authors.lastname: Yee
authors.forename: T M
authors.initials: TM
authors.lastname: Tuttle
authors.forename: L I
authors.initials: LI
authors.lastname: Everson
authors.forename: M
authors.initials: M
authors.lastname: Garwood
mesh_terms: D000328:Adult; D000465:Algorithms; D001834:Body Water; D001943:Breast Neoplasms / Q000737:chemistry* / Q000175:diagnosis*; D004058:Diffusion; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014867:Water / Q000032:analysis*; D055815:Young Adult
chemical_list: D014867:Water