title: The role of statins in chronic heart failure.
abstract: OBJECTIVE
  To discuss unresolved issues and recent findings regarding the use of statins in heart failure.
  
  
  RESULTS
  Recent data from Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto miocardico--Heart Failure and Controlled Rosuvastatin Multinational Trial in Heart Failure suggest that statins did not have any effect on outcome despite significant reduction in low-density lipoprotein and high sensitivity C-reactive protein.
  
  
  CONCLUSIONS
  Most of the evidence for the use of statins in heart failure originates from retrospective trials and post-hoc analyses, and is not supported by prospective randomized clinical trials. There is no evidence to support initiating statin therapy in patients with symptomatic New York Heart Association II-IV heart failure, regardless of the cause.
authors.affiliation: Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
authors.forename: Mouhannad M
authors.initials: MM
authors.lastname: Sadek
authors.forename: Taleen
authors.initials: T
authors.lastname: Haddad
authors.forename: Haissam
authors.initials: H
authors.lastname: Haddad
mesh_terms: D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D012189:Retrospective Studies
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors