title: Pulsatile perfusion with intra-aortic balloon pumping ameliorates whole body response to cardiopulmonary bypass in the elderly.
abstract: OBJECTIVE
  The growing life expectancy has led the elderly to be increasingly referred to coronary artery bypass grafting. Preexisting comorbidities may benefit from theoretical advantages of pulsatile perfusion during cardiopulmonary bypass (CPB).
  
  
  METHODS
  Prospective randomized trial.
  
  
  METHODS
  Cardiac surgery unit in a university hospital.
  
  
  METHODS
  Eighty consecutive patients older than 70 years.
  
  
  METHODS
  Elective coronary artery bypass grafting on CPB, randomizing to conventional linear CPB (40 patients, group A) or intra-aortic balloon pump (IABP)-induced pulsatile CPB (40 patients, group B).
  
  
  RESULTS
  We evaluated hemodynamic response by pulmonary artery flotation catheter, metabolic/splanchnic response by lactate and transaminase, bilirubin, amylase, and renal function (creatinine clearance, creatinine, incidence of renal insufficiency and failure), respiratory response by Pao2/Fio2, respiratory compliance, scoring of chest radiograph, intubation time, and need for noninvasive positive-pressure ventilation, hematologic response by chest drainage, hemocoagulative and fibrinolytic cascades, and transfusions. IABP-related complications were recorded. Two minor IABP-related complications (2.5%) were registered. Hemodynamics was comparable, except for a slightly better cardiac index and indexed systemic vascular resistances at the end of CPB and at intensive therapy unit (ITU) admission (p < 0.05). Transaminases, bilirubin, amylase, proved lower in group B (p < 0.05 from ITU admission to 48 hours). Creatinine clearance, serum creatinine, and lactate were better in group B (p < 0.05), and acute renal insufficiency was accordingly lower (p = 0.02). Respiratory response demonstrated better Pao2/Fio2 and respiratory compliance from aortic declamping to 48 hours, with better scoring of chest radiograph (p < 0.05 from ITU admission to 48 hours), lower noninvasive positive-pressure ventilation (p = 0.002) and intubation time (p = 0.031) in group B. Lower chest drainage (p < 0.05 at first and second day), transfusions (p < 0.05), activated partial thromboplastin time, international normalized ratio, white blood cells, and D-dimer (p < 0.05 from ITU admission to 48 hours), together with higher platelets, fibrinogen, and antithrombin III (p < 0.05 from ITU admission to 48 hours) were demonstrated in the pulsated group.
  
  
  CONCLUSIONS
  IABP-induced pulsatile flow significantly improves whole body perfusion in the elderly undergoing CPB.
authors.affiliation: Cardiac Surgery Unit, Magna Graecia University of Catanzaro, Catanzaro, Italy. frankono@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Onorati
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santarpino
authors.forename: Pierangela
authors.initials: P
authors.lastname: Presta
authors.forename: Santo
authors.initials: S
authors.lastname: Caroleo
authors.forename: Karim
authors.initials: K
authors.lastname: Abdalla
authors.forename: Ermenegildo
authors.initials: E
authors.lastname: Santangelo
authors.forename: Elio
authors.initials: E
authors.lastname: Gulletta
authors.forename: Giorgio
authors.initials: G
authors.lastname: Fuiano
authors.forename: Francesco Saverio
authors.initials: FS
authors.lastname: Costanzo
authors.forename: Attilio
authors.initials: A
authors.lastname: Renzulli
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass; D003131:Combined Modality Therapy; D003324:Coronary Artery Disease / Q000601:surgery*; D005260:Female; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008297:Male; D011446:Prospective Studies; D011673:Pulsatile Flow; D016896:Treatment Outcome