Oral granulocytic sarcoma: a case report.
Granulocytic sarcoma (GS) is a localized infiltrate of immature granulocytes in an extramedullary site. This lesion is most frequently associated with leukemia, but can occur associated with other myeloproliferative disorders. GS can affect virtually any part of the body, but oral lesions are rare, with only 37 cases described.


METHODS
We present a case of GS in a 23-year-old female, with a prior history of acute myeloid leukemia, presenting with a solitary mandibular swelling in the region of the erupting lower left 3rd molar. After biopsy, conventional immunohistochemical stains were positive for CD45 (hematological marker) and myeloid markers, such as myeloperoxidase, and CD68, demonstrating a myeloid lineage with monocytic cell differentiation, suggesting the diagnosis of GS associated to AML-M5.


CONCLUSIONS
Although GS is a rare tumor in the oral cavity, and its diagnosis is usually difficult, the clinician must know of its existence in order to make a differential diagnosis.
Osterne
Rafael-Lima-Verde
RL
Postgraduate program in dentistry in Federal University of Ceará Brazil, Brazil. rafael_bbder@yahoo.com.br
Matos-Brito
Renata-Galvão de
RG
Alves
Ana-Paula-Negreiros-Nunes
AP
Nogueira
Teresa-Neuma-Albuquerque-Gomes
TN
Rocha-Filho
Francisco-Dário
FD
Meneses
Francisco-Albano
FA
Sousa
Fabrício-Bitu
FB
D005260:Female; D006801:Humans; D009062:Mouth Neoplasms / Q000473:pathology; D023981:Sarcoma, Myeloid / Q000473:pathology; D055815:Young Adult