Diazonia- and tetraazoniapolycyclic cations as motif for quadruplex-DNA ligands.
It is demonstrated that even unsubstituted cationic ligands, namely the known diazoniadibenzochrysenes (, ) and the so far unreported tetraazoniapentaphenopentaphene (), stabilize quadruplex DNA upon association; the ligand exhibits essentially the same affinity towards the quadruplex as does 5,10,15,20-tetrakis(1-methyl-4-pyridyl)-21H,23H-porphine, however, with a significantly higher selectivity for quadruplex relative to duplex DNA.
Granzhan
Anton
A
University of Siegen, Organic Chemistry, Adolf-Reichwein-Str. 2, D-57068 Siegen, Germany.
Ihmels
Heiko
H
Jäger
Katharina
K
D002412:Cations / Q000737:chemistry; D002942:Circular Dichroism; D003979:Diazonium Compounds / Q000737:chemistry*; D054856:G-Quadruplexes; D008024:Ligands; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000737:chemistry*
D002412:Cations; D003979:Diazonium Compounds; D008024:Ligands; D011083:Polycyclic Compounds