Pathogenesis of bone and mineral related disorders in chronic kidney disease: key role of hyperphosphatemia.
This paper reviews the pathogenesis of hyperphosphataemia and its role in the regulation of parathyroid hormone synthesis and parathyroid cell proliferation in chronic kidney disease. The association between hyperphosphaemia and vascular calcification, and the interventions that can be used to control plasma phosphate are also discussed.
Román-García
Pablo
P
Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Instituto Reina Sofía de Investigación, REDinREN del ISCIII, Universidad de Oviedo, Oviedo, Asturias, Spain.
Carrillo-López
Natalia
N
Cannata-Andía
Jorge B
JB
D000536:Aluminum Hydroxide / Q000009:adverse effects / Q000627:therapeutic use; D002114:Calcinosis / Q000209:etiology; D002117:Calcitriol / Q000502:physiology; D002118:Calcium / Q000502:physiology; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology; D018753:Diet, Protein-Restricted / Q000379:methods; D018450:Disease Progression; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000209:etiology; D054559:Hyperphosphatemia / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy*; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D010758:Phosphorus / Q000502:physiology; D016226:Phosphorus, Dietary / Q000009:adverse effects; D006435:Renal Dialysis; D012307:Risk Factors; D014652:Vascular Diseases / Q000209:etiology
D016226:Phosphorus, Dietary; D010758:Phosphorus; D000536:Aluminum Hydroxide; D002117:Calcitriol; D002118:Calcium