title: Immunoexpression of keratins in the calcifying cystic odontogenic tumor epithelium.
abstract: Ameloblastomatous epithelium containing clusters of ghost cells is the typical histopathology of calcifying cystic odontogenic tumor (CCOT). This paper aimed to assess keratins AE1-AE3, K7, K10/13, K14, K18, K19, vimentin, laminin, and collagen IV in 08 CCOTs to discuss their histopathogenesis. Similarity to the immunoprofile of the stratified squamous epithelium was seen in the with the basal layer expressing K14 and the upper cells expressing K10/13. When compared to the immunoprofile of the normal odontogenic epithelium, of odontogenic tumor epithelia and of the ghost cells described in the literature, it was possible to suggest that the CCOT epithelium differentiates towards squamous type.
authors.affiliation: Department of Pathology and Clinical Propaedeutic, Araçatuba College of Dentistry, São Paulo State University, São Paulo, Brazil. mmcrivel@foa.unesp.br
authors.forename: Marcelo Macedo
authors.initials: MM
authors.lastname: Crivelini
authors.forename: Renata Callestini
authors.initials: RC
authors.lastname: Felipini
authors.forename: Gilberto Aparecido
authors.initials: GA
authors.lastname: Coclete
authors.forename: Ana Maria Pires
authors.initials: AM
authors.lastname: Soubhia
mesh_terms: D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic; D024141:Collagen Type IV / Q000096:biosynthesis; D004848:Epithelium / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007573:Jaw Neoplasms / Q000378:metabolism* / Q000473:pathology*; D007633:Keratins / Q000096:biosynthesis*; D007797:Laminin / Q000096:biosynthesis; D018333:Odontogenic Cyst, Calcifying / Q000378:metabolism* / Q000473:pathology*; D014746:Vimentin / Q000096:biosynthesis
chemical_list: D024141:Collagen Type IV; D007797:Laminin; D014746:Vimentin; D007633:Keratins