title: Incidence of small bowel injury induced by low-dose aspirin: a crossover study using capsule endoscopy in healthy volunteers.
abstract: OBJECTIVE
  Small intestinal toxicity of low-dose aspirin remains unclear. The purpose of this capsule endoscopy study was to assess the incidence of small bowel injury in healthy volunteers treated with short-term low-dose aspirin.
  
  
  METHODS
  Healthy subjects were randomly assigned to receive low-dose aspirin for 14 days (Aspirin group) or no drugs for 14 days (Control group). The two treatment occasions were separated by a washout period of at least 4 weeks. All subjects underwent capsule endoscopy at the end of each treatment period.
  
  
  RESULTS
  After 2 weeks of treatment, the percentages of subjects with small bowel pathology were 80% in the Aspirin group compared with 20% in the Control group (p = 0.023). The incidence of small bowel mucosal breaks in the Aspirin group was higher than that in the Control group, although the difference was not significant (30 vs. 0%; p = 0.210).
  
  
  CONCLUSIONS
  This is the first pilot study using capsule endoscopy to report on the relation between small bowel injury and low-dose aspirin. Among the healthy subjects, the short-term administration of low-dose aspirin was associated with a mild mucosal inflammation of the small bowel.
authors.affiliation: Division of Gastroenterology, Yokohama City University School of Medicine, Kanazawa-ku, Yokohama, Japan. t066011b@yokohama-cu.ac.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hosono
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
authors.forename: Shingo
authors.initials: S
authors.lastname: Kato
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nozaki
authors.forename: Kyoko
authors.initials: K
authors.lastname: Yoneda
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Koji
authors.initials: K
authors.lastname: Fujita
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kirikoshi
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kubota
authors.forename: Satoru
authors.initials: S
authors.lastname: Saito
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Matsuhashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D053704:Capsule Endoscopy; D016009:Chi-Square Distribution; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015994:Incidence; D007410:Intestinal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007421:Intestine, Small; D008297:Male; D010865:Pilot Projects; D018709:Statistics, Nonparametric
chemical_list: D001241:Aspirin