title: [An uncommon malignancy of the breast: dermatofibrosarcoma protuberans with fibrosarcomatous transformation (DFSP-FS)].
abstract: Dermatofibrosarcoma protuberans (DFSP) is a morphologically distinct dermal/subcutaneous fibrohystiocytic neoplasm seen mainly on the trunk and the proximal extremities, which generally is regarded as a low-grade or "borderline" neoplasm. Dermatofibrosarcoma protuberans is characterized clinically by locally aggressive growth and a high rate of local recurrence, but distant metastases and tumor-related deaths are very rare. DFSP in the breast is extremely uncommon. Immunohistochemically, DFSP is characterized by positive staining for vimentin and CD34. We present a case of a 65 years old female patient with a giant DFSP developed in the sight of several excised fibroadenoma and neurofibroma treated by radical mastectomy and axillary block-dissection. Perioperative hystological and immunohistochemical images demonstrate the characteristics of the giant nonphylloid sarcoma.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar II sz Sebészeti Klinika, Budapest. lednic@kut.sote.hu
authors.forename: György
authors.initials: G
authors.lastname: Ledniczky
authors.forename: Gábor
authors.initials: G
authors.lastname: Bognár
authors.forename: Csaba
authors.initials: C
authors.lastname: Diczházi
authors.forename: Bíborka
authors.initials: B
authors.lastname: Bereczky
authors.forename: Loránd
authors.initials: L
authors.lastname: Barabás
authors.forename: Pál
authors.initials: P
authors.lastname: Ondrejka
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D001365:Axilla; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D002471:Cell Transformation, Neoplastic / Q000737:chemistry / Q000473:pathology; D018223:Dermatofibrosarcoma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008197:Lymph Node Excision; D015411:Mastectomy, Modified Radical; D014746:Vimentin / Q000032:analysis
chemical_list: D018952:Antigens, CD34; D014408:Biomarkers, Tumor; D014746:Vimentin