Multifunctional coprocessed excipients for improved tabletting performance.
With the advancement of tablet manufacturing process, the demand of excipients with improved functionalities, mainly in terms of flow and compression properties, has increased. Coprocessed excipients are a mixture of two or more existing excipients at subparticle level, offer substantial benefits of the incorporated excipients and minimize their drawbacks. These multipurpose excipients have dramatically reduced the number of incorporating excipients in the tablet. The present review discusses the potential advantages of coprocessing and coprocessed excipients, material characteristics required for coprocessing, methods of coprocessing and various coprocessed excipients for direct compression available in the market.
Saha
Sumit
S
National Institute of Pharmaceutical Education and Research (NIPER)-Ahmedabad, C/o. B.V. Patel Pharmaceutical Education and Research Development Centre, S.G. Highway, Thaltej, Ahmedabad-380054, India.
Shahiwala
Aliasgar F
AF
D002241:Carbohydrates / Q000737:chemistry; D002482:Cellulose / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D017277:Drug Approval; D005079:Excipients / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000737:chemistry; D013402:Sugar Alcohols / Q000737:chemistry; D013607:Tablets / Q000737:chemistry*
D002241:Carbohydrates; D005079:Excipients; D004364:Pharmaceutical Preparations; D013402:Sugar Alcohols; D013607:Tablets; D002482:Cellulose; D007785:Lactose