Acylated iridoids with cytotoxicity from Valeriana jatamansi.
Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.
Lin
Sheng
S
Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
Shen
Yun-Heng
YH
Li
Hui-Liang
HL
Yang
Xian-Wen
XW
Chen
Tao
T
Lu
Long-Hai
LH
Huang
Zheng-Sheng
ZS
Liu
Run-Hui
RH
Xu
Xi-Ke
XK
Zhang
Wei-Dong
WD
Wang
Hui
H
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014632:Valerian / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D039823:Iridoids