title: [Metronidazole-related polyneuritis, convulsive seizures, and cerebellar syndrome. Contribution of MRI].
abstract: BACKGROUND
  Neurological complications of metronidazole are rare, predominantly peripheral neuropathies, especially in patients on a long-term high-dose regimen. Cerebellar syndrome or seizures are less frequently reported. The concomitant occurrence of the three complications is exceptional.
  
  
  METHODS
  We report herein a case with these three complications as side effects of metronidazole. For the cerebellar syndrome, the T2-weighted brain MRI showed a rounded and well-delimited zone of high signal intensity in the cerebellar dentate nuclei, extending up to the protuberance and the subthalamic nucleus, bilaterally and symmetrically.
  
  
  CONCLUSIONS
  Neurological complications are possible when a treatment with metronidazole is prescribed for a long duration or at high dose. In our patient, the clinical abnormalities and MRI signs regressed a few months after treatment withdrawal.
authors.affiliation: hôpital Tenon, Paris, France. jean-pierre.ferroir@tnn.aphp.fr
authors.forename: J-P
authors.initials: JP
authors.lastname: Ferroir
authors.forename: C
authors.initials: C
authors.lastname: Corpechot
authors.forename: A
authors.initials: A
authors.lastname: Freudenreich
authors.forename: A
authors.initials: A
authors.lastname: Khalil
mesh_terms: D000368:Aged; D002526:Cerebellar Diseases / Q000139:chemically induced* / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D004831:Epilepsies, Myoclonic / Q000139:chemically induced / Q000503:physiopathology; D006801:Humans; D016031:Liver Transplantation; D008279:Magnetic Resonance Imaging; D008297:Male; D008795:Metronidazole / Q000009:adverse effects*; D009443:Neuritis / Q000139:chemically induced* / Q000473:pathology; D012640:Seizures / Q000139:chemically induced* / Q000473:pathology; D020531:Subthalamic Nucleus / Q000473:pathology; D014961:X-Ray Diffraction
chemical_list: D008795:Metronidazole