Helical organization in foldable aromatic oligoamides by a continuous hydrogen-bonding network.
Introduction of a continuous internal hydrogen-bonding network suppressed the conformational flexibility of a series of oligoaromatic foldamers with a lengthened backbone. The helical ordering over up to six aromatic repeating units was established in solution by a 2D NOESY study and in the solid state by an X-ray diffraction method. Computational molecular modeling further corroborates the experimentally observed helical propagation in this class of foldable molecular strands.
Yan
Yan
Y
Department of Chemistry and NUS MedChem Program of the Office of Life Sciences, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Qin
Bo
B
Shu
Yingying
Y
Chen
Xiuying
X
Yip
Yeow Kwan
YK
Zhang
Dawei
D
Su
Haibin
H
Zeng
Huaqiang
H
D000577:Amides / Q000737:chemistry; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry*
D000577:Amides; D011108:Polymers