title: The effectiveness of silver-releasing dressings in the management of non-healing chronic wounds: a meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to examine the efficacy of silver-releasing dressings in the management of non-healing chronic wounds.
  
  
  BACKGROUND
  Non-healing chronic wounds often have a negative physical impact on patients and place a financial burden on healthcare systems. Silver dressings are wound products designed to control infection and provide a wound environment conducive to healing. However, validation of the clinical efficacy of these dressings is lacking.
  
  
  METHODS
  Systematic review and meta-analysis.
  
  
  METHODS
  A systematic search of the major electronic databases PubMed, CINAHL, Cochrane, MEDLINE, British Nursing Index, EBSCO, OCLC and Proquest between 1950-June 2007 was conducted. Hand searches of selected periodicals, textbooks and checking reference lists and contacting experts was also performed.
  
  
  RESULTS
  Eight studies were selected from a potentially relevant 1957 references screened. Analysis incorporated data from 1399 participants in the eight randomised control trials. We found that silver dressings significantly improved wound healing (CI(95): 0.16-0.39, p < 0.001), reduced odour (CI(95): 0.24-0.52, p < 0.001) and pain-related symptoms (CI(95): 0.18-0.47, p < 0.001), decreased wound exudates (CI(95): 0.17-0.44, p < 0.001) and had a prolonged dressing wear time (CI(95): 0.19-0.48, p = 0.028) when compared with alternative wound management approaches. An analysis of sensitivity in these studies by subgroup analysis generally supported these associations. Furthermore, studies indicated an improvement in quality of life (CI(95): 0.04-0.33, p = 0.013) using silver dressings in wound management with no associated severe adverse events.
  
  
  CONCLUSIONS
  This meta-analysis confirms the effectiveness of silver dressings in wound healing and improving patients' quality of life. However, it also highlights the need for additional well-designed randomised controlled trials to evaluate the effectiveness of silver-related dressings further.
  
  
  CONCLUSIONS
  The results of this study provide objective data on the effectiveness of silver-related dressing when applied to non-healing chronic wounds.
authors.affiliation: Department of Nursing, Tzu Chi College of Technology, Taipei, Taiwan.
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Lo
authors.forename: Chee-Jen
authors.initials: CJ
authors.lastname: Chang
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Hu
authors.forename: Mark
authors.initials: M
authors.lastname: Hayter
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Chang
mesh_terms: D000368:Aged; D001458:Bandages / Q000145:classification / Q000592:standards; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017594:Publication Bias; D016032:Randomized Controlled Trials as Topic; D018030:Silver Compounds / Q000008:administration & dosage*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000451:nursing / Q000628:therapy*
chemical_list: D018030:Silver Compounds