title: Does asthma control correlate with quality of life related to upper and lower airways? A real life study.
abstract: BACKGROUND
  The goal of asthma therapy is to achieve an optimal level of disease control, but the relationship between asthma control, impact of comorbid rhinitis and health related quality of life (HRQoL) in real life remains unexplored.
  
  
  OBJECTIVE
  The aims of this real life study were to evaluate asthma control, the impact of asthma (with and without rhinitis) on HRQoL, the relationship between asthma control and HRQoL, and the role of rhinitis on asthma control and HRQoL.
  
  
  METHODS
  122 asthma patients completed the Asthma Control Test, Rhinitis Symptoms score (T5SS) and RHINASTHMA.
  
  
  RESULTS
  Asthma control was unsatisfactory (44.27% of uncontrolled patients), as well as HRQoL. Controlled patients controlled showed significantly lower scores in all the RHINASTHMA domains compared to uncontrolled. Irrespective of their level of control, patients with rhinitis symptoms showed worse HRQoL in Upper Airways (UA) (P < 0.0001), Lower Airways (LA) (P < 0.001), and Global Summary (GS) (P < 0.0001). In patients with symptomatic rhinitis, RHINASTHMA were lower in controlled asthma patients (UA P = 0.002; LA P < 0.0001; RAI P < 0.01; GS P < 0.0001). Asthma control was associated with lower T5SS score (P = 0.034).
  
  
  CONCLUSIONS
  Asthma control in real life is unsatisfactory. Rhinitis and asthma influence each other in terms of control and HRQoL. The control of rhinitis in asthma patients can lead to an optimization of HRQoL related to the upper airways, while this phenomenon is not so evident in asthma. These results suggest to strengthen the ARIA recommendation that asthma patients must be evaluated for rhinitis and vice versa.
authors.affiliation: Allergy and Respiratory Diseases, Department of Internal Medicine, Genoa University, Genoa, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Braido
authors.forename: I
authors.initials: I
authors.lastname: Baiardini
authors.forename: S
authors.initials: S
authors.lastname: Balestracci
authors.forename: V
authors.initials: V
authors.lastname: Ghiglione
authors.forename: E
authors.initials: E
authors.lastname: Stagi
authors.forename: E
authors.initials: E
authors.lastname: Ridolo
authors.forename: R
authors.initials: R
authors.lastname: Nathan
authors.forename: G W
authors.initials: GW
authors.lastname: Canonica
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000523:psychology* / Q000628:therapy*; D015897:Comorbidity; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires