[Comparison of the pharmacokinetics and safety of a paclitaxel injection NK and Taxol injection in breast cancer patients].
A paclitaxel injection NK (NK) is a generic product containing the same amount of ingredient as a Taxol Injection. We examined the pharmacokinetics and safety of NK compared to the original product in breast cancer patients. As a result, the transition of plasma paclitaxel concentration and pharmacokinetic parameter in NK and the original drug were almost equal, which suggested that these products were bioequivalent. In adjuvant therapy, there was no significant difference in adverse events reported, and these products were approximately equally safe.
Sagara
Yoshiaki
Y
Dept. of Breast-Surgical Oncology and Radiology, Sagara Hospital.
Rai
Yoshiaki
Y
Sagara
Yoshiatsu
Y
Matsuyama
Yoshito
Y
Baba
Shinichi
S
Tamada
Shugo
S
Sagara
Yasuaki
Y
Ando
Mitsutake
M
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects* / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D017239:Paclitaxel