Intramolecular hydroamination of unactivated alkenes with secondary alkyl- and arylamines employing [Ir(COD)Cl]2 as a catalyst precursor.
Commercially available [Ir(COD)Cl](2) is an effective precatalyst for the intramolecular hydroamination of a range of unactivated alkenes with pendant secondary alkyl- or arylamines, at relatively low loadings (typically 0.25-5.0 mol % Ir) and without the need for added ligands or other cocatalysts.
Hesp
Kevin D
KD
Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3.
Stradiotto
Mark
M