Mansoquinone: isolation and structure elucidation of new antibacterial aromatic polyketides from terrestrial Streptomyces Sp. Eg5.
The cultivation of terrestrial Streptomyces Sp. Eg5 delivered two new aromatic polyketides, 2-butyryl-1,8-dihydroxy-3-methylanthraquinone (2), or mansoquinone, and 2-acetyl-1,8-dihydroxy-3-methyl-anthra-quinone (3) along with the known 2-ethyl-1,8-dihydroxy-3-methylanthraquinone (1). The structure of mansoquinone (2) was elucidated using detailed spectral ((1)H and (13)C NMR, (1)H-(1)H COSY, HSQC, HMBC and HRMS) analysis. This is the first report of the isolation of 3 from natural source. Mansoquinone (2) exhibited moderate antibacterial activities against Escherichia coli, Bacillus subtilis and Staphylococcus aureus.
Abdelfattah
Mohamed S
MS
Faculty of Science, Chemistry Department, Helwan University, Ain Helwan, Cairo, Egypt. mabdelfattah_13@yahoo.com
D000880:Anthraquinones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004926:Escherichia coli / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013211:Staphylococcus aureus / Q000187:drug effects; D013302:Streptomyces / Q000737:chemistry*
D000880:Anthraquinones; D000900:Anti-Bacterial Agents