title: Stereotactic radiotherapy for lung cancer using a flattening filter free Clinac.
abstract: The objective of this study was to assess the feasibility of stereotactic radiotherapy for early stage lung cancer using photon beams from a Varian Clinac accelerator operated without a flattening filter. Treatment plans were generated for 10 lung cancer patients with isolated lesions less than 3 cm in diameter. For each patient, two plans were generated, one with and one without the flattening filter. Plans were generated with Eclipse 8.0 (Varian Medical Systems) commissioned with beam data measured on a Clinac 21EX (Varian Medical Systems) operated with and without the flattening filter. Removal of the flattening filter increased the dose rate. The median beam-on time per field was reduced from 25 sec (with the filter) to 11 sec (without the filter), increasing the feasibility of breath-hold treatments and the efficiency of gated treatments. Differences in a dose heterogeneity index for the planning target volume between plans with flattened and unflattened beams were statistically insignificant. Differences in mean doses to organs at risk were small, typically about 10 cGy over the entire treatment. The study concludes that radiotherapy with unflattened beams is feasible and requires substantially less beam-on time, facilitating breath-hold and gating techniques.
authors.affiliation: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Oleg N
authors.initials: ON
authors.lastname: Vassiliev
authors.affiliation: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Kry
authors.affiliation: Department Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Joe Y
authors.initials: JY
authors.lastname: Chang
authors.affiliation: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Balter
authors.affiliation: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Uwe
authors.initials: U
authors.lastname: Titt
authors.affiliation: Department of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, U.S.A.
authors.forename: Radhe
authors.initials: R
authors.lastname: Mohan
mesh_terms: D005240:Feasibility Studies; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D016634:Radiosurgery / Q000379:methods*; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000295:instrumentation / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation / Q000379:methods