Swietenine: a potential oral hypoglycemic from Swietenia macrophylla seed.
Swietenine, a tetranortriterpenoid, was isolated from the Swietenia macrophylla seeds. The in vivo hypoglycemic activity was evaluated against neonatal-streptozotocin induced type 2 diabetic rats. Oral administration of swietenine at 25 and 50 mg/kg body weight per day to diabetic rats was found to possess significant dose dependant hypoglycemic and hypolipidemic activity in type 2 diabetic rats.
Dewanjee
Saikat
S
Division of Pharmacognosy, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India. s.dewanjee@yahoo.com
Maiti
Anup
A
Das
Anup K
AK
Mandal
Subhash C
SC
Dey
Sankar P
SP
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D036701:Limonins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D029582:Meliaceae / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds
D007004:Hypoglycemic Agents; D036701:Limonins; D010936:Plant Extracts; C546524:swietenine