Who and where is the renal baroreceptor?: the connexin hypothesis.
Gap junctions are emerging as a fundamental mechanism for the control of renin synthesis and release. Connexin40 is prominent in juxtaglomerular cells. When missing, it results in hyperreninemia and hypertension. Schweda et al. offer exciting data demonstrating that connexin45, a connexin with different biophysical properties, can replace connexin40 functions related to the control of renin.
Gomez
R Ariel
RA
Department of Pediatrics, University of Virginia Medical Center, Charlottesville, Virginia 22908, USA. rg@virginia.edu
Sequeira Lopez
Maria Luisa S
ML
D000818:Animals; D017630:Connexins / Q000502:physiology*; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D007606:Juxtaglomerular Apparatus / Q000502:physiology; D051379:Mice; D012083:Renin / Q000378:metabolism*; D012084:Renin-Angiotensin System; D000097003:Gap Junction alpha-5 Protein
D017630:Connexins; D012083:Renin; D000097003:Gap Junction alpha-5 Protein; C082920:connexin 45