title: Flexible nerve stimulation electrode with iridium oxide sputtered on liquid crystal polymer.
abstract: Current electrode designs require flexible substrates that absorb little moisture and provide large charge injection capability. Sputtered iridium oxide films have superior charge injection capabilities versus noble metals and can adhere to various substrates. Liquid crystal polymers (LCPs) have very little water absorption compared to other flexible substrates. Therefore, the combination of sputtered iridium oxide film on LCP substrate was studied using 50 Hz, 100 micros duration, and 10 mA biphasic current waveforms for 700 h at 67 degrees C in bicarbonate buffer saline. Scanning electron micrograph analysis showed no delamination and approximately 1% of electrode material was lost to the bicarbonate buffer. The charge injection limit and the cathodic charge storage capacity within the water window were 4.6 +/- 1.0 and 31.5 +/-6.6 mC/cm2, respectively. Additional electrochemical analysis revealed significant charge imbalance attributed to oxygen reduction within the water window. These results, along with the flexible, chemically inert, and biocompatible substrate, indicate that sputtered iridium oxide films on LCP could become the method of choice for flexible substrate nerve electrodes.
authors.affiliation: Department of Biomedical Engineering and the Neural Engineering Center, Case Western Reserve University, Cleveland, OH 44106, USA. kxw18@case.edu
authors.forename: Kevin
authors.initials: K
authors.lastname: Wang
authors.forename: Chung-Chiun
authors.initials: CC
authors.lastname: Liu
authors.forename: Dominique M
authors.initials: DM
authors.lastname: Durand
mesh_terms: D004558:Electric Stimulation / Q000295:instrumentation*; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D004563:Electrochemistry; D004566:Electrodes; D007495:Iridium / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011474:Prosthesis Design
chemical_list: D011108:Polymers; C422409:liquid crystal polymer; C044458:iridium oxide; D007495:Iridium; D010100:Oxygen