title: Kinase domain mutations in cancer: implications for small molecule drug design strategies.
authors.affiliation: Chemical Sciences, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, USA. bikkerj@wyeth.com
authors.forename: Jack A
authors.initials: JA
authors.lastname: Bikker
authors.forename: Natasja
authors.initials: N
authors.lastname: Brooijmans
authors.forename: Allan
authors.initials: A
authors.lastname: Wissner
authors.forename: Tarek S
authors.initials: TS
authors.lastname: Mansour
mesh_terms: D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D010770:Phosphotransferases / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics*; D011487:Protein Conformation
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D010770:Phosphotransferases