Interleukin-4 as a neuromodulatory cytokine: roles and signaling in the nervous system.
Although interleukin (IL)-4 is described as a prototypical anti-inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL-4 during the development and normal physiology of neural cells as well as IL-4 connections with the pathophysiology of degenerative or inflammatory processes observed in the central and peripheral nervous system.
Sholl-Franco
Alfred
A
Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. asholl@biof.ufrj.br
da Silva
Ana Gabriela Ledo Santos
AG
Adão-Novaes
Juliana
J
D000818:Animals; D004194:Disease; D006801:Humans; D015847:Interleukin-4 / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism* / Q000473:pathology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D019948:Receptors, Interleukin-4 / Q000378:metabolism; D015398:Signal Transduction
D018377:Neurotransmitter Agents; D019948:Receptors, Interleukin-4; D015847:Interleukin-4