Effect of nadcin on energy supply system and apoptosis in ischemia-reperfusion injury to the myocardium.
Nadcin in a dose of 90 mg/kg administered to dogs with subacute stage of ischemia-reperfusion myocardial injury immediately after blood flow resumption normalized redox potential of cardiomyocytes and mitochondria and restored the total content of adenyl and pyridine nucleotides. The decrease in the synthesis of ATP and pyridine nucleotides and reduction of the redox potential of the energy supply system were inversely related to the increase in poly-(ADP-ribose)-polymerase activity in the ischemic area and nonischemic region. Nadcin abolished the increase in poly-(ADP-ribose)-polymerase activity in the ischemic area of the right ventricle, nonischemic region, and ischemic area of the left ventricle (by 2.4, 2.9, and 1.52 times, respectively) and normalized bioenergetic activity of cardiomyocytes during ischemia-reperfusion myocardial injury.
Sukoyan
G V
GV
N. V. Karsanov Republican Research Center for Medical Biophysics and Implementation of New Biomedical Technologies, Tbilisi, Georgia.
Kavadze
I K
IK
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004285:Dogs; D004338:Drug Combinations; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D007288:Inosine / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D009243:NAD / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism
D000227:Adenine Nucleotides; D004338:Drug Combinations; C539375:nadcin; D009243:NAD; D007288:Inosine; D011065:Poly(ADP-ribose) Polymerases