title: Identifying protein-coding genes in genomic sequences.
abstract: The vast majority of the biology of a newly sequenced genome is inferred from the set of encoded proteins. Predicting this set is therefore invariably the first step after the completion of the genome DNA sequence. Here we review the main computational pipelines used to generate the human reference protein-coding gene sets.
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Campus, Hinxton, Cambridge, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Harrow
authors.forename: Alinda
authors.initials: A
authors.lastname: Nagy
authors.forename: Alexandre
authors.initials: A
authors.lastname: Reymond
authors.forename: Tyler
authors.initials: T
authors.lastname: Alioto
authors.forename: Laszlo
authors.initials: L
authors.lastname: Patthy
authors.forename: Stylianos E
authors.initials: SE
authors.lastname: Antonarakis
authors.forename: Roderic
authors.initials: R
authors.lastname: Guigó
mesh_terms: D000818:Animals; D001483:Base Sequence; D019295:Computational Biology / Q000379:methods*; D005796:Genes; D016678:Genome / Q000235:genetics*; D006801:Humans; D011506:Proteins / Q000235:genetics*
chemical_list: D011506:Proteins