Evaluation of live attenuated S79 mumps vaccine effectiveness in mumps outbreaks: a matched case-control study.
BACKGROUND
Mumps virus infection is a potentially serious viral infection of childhood and early adulthood. In China, live attenuated S(79) mumps vaccine has been licensed for pediatric use since 1990. The objective of this study was to determine the effectiveness of live attenuated S(79) mumps vaccine against clinical mumps in outbreaks.


METHODS
Cases were selected from mumps outbreaks in schools in Guangzhou between 2004 and 2005. Each case was matched by gender, age and classroom. Vaccination information was obtained from Children's EPI Administrative Computerized System. Vaccine effectiveness (VE) was calculated for 1 or 2 doses of S(79) vaccine with 95% confidence intervals (CI).


RESULTS
One hundred and ninety-four cases and 194 controls were enrolled into the study. VE of the S(79) mumps vaccine for 1 dose versus 0 confer protection 80.4% (95% CI, 60.0%-90.4%) and VEs against mumps in outbreaks for 1 dose of mumps vaccine are similar among those children aged 4-9 years and aged over 10 years old.


CONCLUSIONS
The live attenuated S(79) mumps vaccine can be effective in preventing clinical mumps outbreaks.
Fu
Chuan-xi
CX
Guangzhou Center of Disease Control and Prevention, Guangzhou, Guangdong 510080, China.
Nie
Jun
J
Liang
Jian-hua
JH
Wang
Ming
M
D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009107:Mumps / Q000453:epidemiology / Q000276:immunology*; D009108:Mumps Vaccine / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology*
D009108:Mumps Vaccine; D014613:Vaccines, Attenuated