Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients.
Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.
Abaan
Ogan Demir
OD
Department of Biology, Middle East Technical University, Ankara, Turkey.
Mutlu
Pelin Kaya
PK
Baran
Yusuf
Y
Atalay
Can
C
Gunduz
Ufuk
U
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D045744:Cell Line, Tumor; D003720:Densitometry; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000502:physiology*; D001613:beta 2-Microglobulin / Q000235:genetics
D027425:ATP-Binding Cassette, Sub-Family C Proteins; D001613:beta 2-Microglobulin; C421109:multidrug resistance-associated protein 1