title: Multilevel diskitis and vertebral osteomyelitis after diskography.
abstract: Diskitis is a rare but serious complication following diskography. The signs and symptoms may be easily confused or attributed to patients' preexisting chronic axial degenerative conditions. Unrecognized, it can progress to deep-seated infection with vertebral osteomyelitis. This article presents a case involving a 4-level destructive vertebral osteomyelitis following multilevel diskography despite prophylactic antibiotics and a double-needle technique. A 38-year-old man with radicular symptoms underwent a microdiskectomy at L4-5. Due to only minimal improvement in pain postoperatively, the patient underwent a diagnostic lumbar diskography at L2-3, L3-4, L4-5, and L5-S1 at an outside institution in consideration for repeat surgical treatment. Following this procedure, the patient continued to have debilitating symptoms and presented to our institution, where evaluation revealed elevated inflammatory biomarkers. Magnetic resonance imaging (MRI) suggested diskitis and vertebral osteomyelitis with compression fractures at the 4 levels where the diskography was performed. The patient was successfully treated with parenteral antibiotics targeted at Staphylococcus saccharolyticus, which was isolated in the culture from an open biopsy specimen after an initial percutaneous biopsy was inconclusive. Magnetic resonance imaging is the best radiologic modality for early diagnosis of this complication. This case demonstrates that early changes on MRI should warrant immediate workup and treatment. Treatment involves at least 6 weeks of parenteral antimicrobial therapy.
authors.affiliation: Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
authors.forename: Mark M
authors.initials: MM
authors.lastname: Mikhael
authors.forename: Harold G
authors.initials: HG
authors.lastname: Bach
authors.forename: Paul M
authors.initials: PM
authors.lastname: Huddleston
authors.forename: Timothy P
authors.initials: TP
authors.lastname: Maus
authors.forename: Elie F
authors.initials: EF
authors.lastname: Berbari
mesh_terms: D000328:Adult; D015299:Discitis / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007268:Injections, Epidural / Q000009:adverse effects*; D008297:Male; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology*; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000209:etiology*; D016896:Treatment Outcome