[Study advances on carcinogens and their metabolites in urine of smokers].
There may contain a great many carcinogens in cigarette smoke. Various carcinogens and their metabolites were quantified in urine of smokers, including trans, trans-muconic acid, S-phenylmercapturic acid, 4-(methylnitrosamino)-1-(3-pyridyl )-1-butanol and its glucuronides and so on. Quantification of carcinogens and their metabolites in urine of smokers could provide information on carcinogen exposure, which may be helpful to the research for mechanisms of carcinogen and in the exploitation of new harmless cigarettes. The study advances on carcinogens and their metabolites in urine of smokers were reviewed.
Wang
Zhen
Z
Cancer Institute, Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 31009, China. milkwort@tom.com
Zhang
Lina
L
D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000652:urine; D002273:Carcinogens / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D009602:Nitrosamines / Q000652:urine*; D011725:Pyridines / Q000652:urine*; D012907:Smoking / Q000652:urine*; D013011:Sorbic Acid / Q000031:analogs & derivatives* / Q000032:analysis
D002273:Carcinogens; D009602:Nitrosamines; D011725:Pyridines; C005939:muconic acid; C053003:S-phenyl-N-acetylcysteine; C099565:4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol; D000111:Acetylcysteine; D013011:Sorbic Acid