Deflecting a canonical antiviral T cell response.
In this issue of Immunity, Gras et al. (2009) provide structural hints on how acquisition of tolerance to a coexpressed MHC class I allele can deflect an antiviral response away from the immunodominant response.
Malissen
Bernard
B
Centre d'Immunologie de Marseille-Luminy, INSERM U631, Centre National de la Recherche Scientifique, UMR 6102, Université de la Méditerranée, Case 906, Marseille Cedex 9, France.
D000818:Animals; D000956:Antigens, Viral / Q000737:chemistry* / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000737:chemistry / Q000276:immunology; D006801:Humans; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology; D017634:Self Tolerance / Q000276:immunology; D013601:T-Lymphocytes / Q000737:chemistry* / Q000276:immunology*
D000956:Antigens, Viral; D011948:Receptors, Antigen, T-Cell