Radical and radical-ionic multicomponent processes.
All in one pot! Radical, radical-ionic, and radical-organometallic MCR are highly convergent processes, representing a useful pathway to molecular and structural diversity (see scheme). This concept article highlights recent developments in the field and shows the potential of the strategy for the economical elaboration of various kinds of organic substrates.Progress in multicomponent reactions (MCRs) based on ionic and organometallic processes has recently allowed the synthesis, with high efficiency, of large collections of drug-like molecules. In contrast, MCRs based on cascade radical reactions appear to have attracted, so far, much less interest. This concept article highlights the latest progress in the field and underlines the potential of such an approach. The collected examples demonstrate that radical and radical-ionic MCRs are highly convergent processes leading to useful structural diversity.
Godineau
Edouard
E
University Bordeaux-1, Institut des Sciences Moléculaires, ISM-UMR 5255, 351, cours de la libération 33405 Talence Cedex, France.
Landais
Yannick
Y