HDL-associated factors provide additional prognostic information for coronary artery disease as determined by multi-detector row computed tomography.
BACKGROUND
A significant relationship has been noted between the lipid profile and atherosclerotic coronary artery disease (CAD) using invasive coronary angiography. We tested the hypothesis that the severity of CAD as determined by a non-invasive method, multi-detector row computed tomography (MDCT), is also associated with lipidemic factors.


RESULTS
The subjects included 195 consecutive patients who underwent coronary angiography using MDCT because of suspected CAD. The number of significantly stenosed vessels (VD) as evaluated by MDCT, platelet-activating factor acetylhydrolase (PAF-AH), free cholesterol (FC), phospholipid (PL), remnant-like lipoprotein particle-cholesterol (RLP-C), apolipoprotein (apo)-B, apo-C3, apo-E, and highly-sensitive C-reactive protein were determined. The subjects were divided into diabetes mellitus (DM) and non-DM groups. The HDL-associated PAF-AH level in the DM group was significantly lower than that in the non-DM group. The VD determined by MDCT was significantly associated with hypertension, administration of angiotensin II type 1 receptor blocker, high-density lipoprotein cholesterol (HDL-C), HDL-associated (H)-HDL, H-PL, H-FC and RLP-C. Multivariate analysis revealed that VD determined by MDCT was most closely correlated with HDL-C.


CONCLUSIONS
Lower levels of HDL-C may be an indicator for and provide additional information regarding the severity of CAD compared with other lipidemic factors.
Mitsutake
Ryoko
R
Department of Cardiology, Fukuoka University School of Medicine, Fukuoka, Japan.
Miura
Shin-ichiro
S
Zhang
Bo
B
Saku
Keijiro
K
D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood*; D017023:Coronary Angiography / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D015203:Reproducibility of Results; D012307:Risk Factors; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data*
D015415:Biomarkers; D008076:Cholesterol, HDL; D002097:C-Reactive Protein; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase