Custom astrocyte-mediated vasomotor responses to neuronal energy demand.
Astrocytes mediate either constriction or dilation of local brain arterioles in response to synaptic activity. Recent work indicates that the directionality of this response may be dictated by ambient oxygen levels.
LeMaistre
Jillian L
JL
Department of Pharmacology and Therapeutics, University of Manitoba, and Division of Neurodegenerative Disorders, St Boniface Hospital Research Centre, 351 Taché Avenue, Winnipeg, MB R2H2A6, Canada. canderson@sbrc.ca
Anderson
Christopher M
CM
D001160:Arterioles / Q000502:physiology; D001253:Astrocytes / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000166:cytology; D004734:Energy Metabolism; D010100:Oxygen / Q000032:analysis / Q000502:physiology; D014661:Vasoconstriction; D014664:Vasodilation; D014666:Vasomotor System / Q000502:physiology*
D010100:Oxygen