title: [Prognostic role of vascularisation and proliferation in rectal cancer with liver metastasis].
abstract: BACKGROUND
  The present study was designed to provide an analysis of factors for angiogenesis and proliferation.
  
  
  METHODS
  We analyzed tumor tissues from 37 rectal cancer patients with concurrent or subsequent liver metastasis underwent preoperative radiotherapy, surgery and adjuvant chemotherapy. Immunohistochemistry was used for expression of proliferation (staining with anti-Ki67: MIB-1) and for detection of microvessel density (MVD, expressed by CD34). Clinicopathological findings were compared with outcome with emphasis to IHC.
  
  
  RESULTS
  A vascular enumeration and pN status and the time of presence of the metastases has shown prognostic role along with the factors above. Increased proliferative activity of the tumor as expressed by MIB-1 staining has no prognostic value, similarly to the localization of tumor, gender, age or grading.
  
  
  CONCLUSIONS
  Different prognostic and predictive factors in colorectal cancer have been reported. Higher pN status and tumor vascularisation has been linked to poor prognosis in overall survival and tumor recurrence.
authors.affiliation: Semmelweis Egyetem, Altalános Orvostudományi Kar II. sz. Sebészeti Klinika, Budapest. bgabor@kut.sote.hu
authors.forename: Gábor
authors.initials: G
authors.lastname: Bognár
authors.forename: Andreas
authors.initials: A
authors.lastname: Imdahl
authors.forename: Bíborka
authors.initials: B
authors.lastname: Bereczky
authors.forename: György
authors.initials: G
authors.lastname: Ledniczky
authors.forename: Gábor
authors.initials: G
authors.lastname: István
authors.forename: Eva Katalin
authors.initials: EK
authors.lastname: Tóth
authors.forename: Christian
authors.initials: C
authors.lastname: Ihling
authors.forename: Pál
authors.initials: P
authors.lastname: Ondrejka
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000401:mortality / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D049109:Cell Proliferation; D003110:Colonic Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D011237:Predictive Value of Tests; D011379:Prognosis; D016016:Proportional Hazards Models
chemical_list: D014408:Biomarkers, Tumor