[Assessment of the level of immunoglobulin E in patients with pyo-inflammatory diseases and its influence on the course of the infectious process].
The level of immunoglobulin E (IgE) in patients with different pyo-inflammatory diseases was assessed and it was found to elevate in patients with acute appendicitis in 49% of cases, in patients with chronic relapsing furunculosis (CRF) in 41%, with chronic osteomyelitis--in 66.6%. In 8 out of 16 examined patients with the elevated level of IgE there were antibodies to toxocars in titers 1:800, 1:400. No correlation with the IgE level was found in assessing the level of IL-4 and gamma-IFN in blood serum of patients with CRF. In patients with acute appendicitis, CRF and chronic osteomyelitis the elevated level of IgE can be considered as a marker of unfavorable course of pyo-inflammatory diseases. The elevated level of IgE does not influence the oxygen-dependent mechanisms of bactericidal action of neutrophils.
Druzhinina
T A
TA
Molotilov
B A
BA
Ivachev
A S
AS
Peskov
A V
AV
Levashova
O A
OA
Titova
E V
EV
D000208:Acute Disease; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D001064:Appendicitis / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D018450:Disease Progression; D005667:Furunculosis / Q000097:blood* / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D010019:Osteomyelitis / Q000097:blood* / Q000276:immunology; D012008:Recurrence
D000888:Antibodies, Anti-Idiotypic; D015415:Biomarkers; D007073:Immunoglobulin E