title: The molecular basis of chromatin dynamics during nucleotide excision repair.
abstract: The assembly of DNA into chromatin in eukaryotic cells affects all DNA-related cellular activities, such as replication, transcription, recombination, and repair. Rearrangement of chromatin structure during nucleotide excision repair (NER) was discovered more than 2 decades ago. However, the molecular basis of chromatin dynamics during NER remains undefined. Pioneering studies in the field of gene transcription have shown that ATP-dependent chromatin-remodeling complexes and histone-modifying enzymes play a critical role in chromatin dynamics during transcription. Similarly, recent studies have demonstrated that the SWI/SNF chromatin-remodeling complex facilitates NER both in vitro and in vivo. Additionally, histone acetylation has also been linked to the NER of ultraviolet light damage. In this article, we will discuss the role of these identified chromatin-modifying activities in NER.
authors.affiliation: Department of Biochemistry and Molecular Biology, Miller School of Medicine, University of Miami, Miami, FL 33156, USA.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Kristi
authors.initials: K
authors.lastname: Jones
authors.forename: Feng
authors.initials: F
authors.lastname: Gong
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D004260:DNA Repair; D006657:Histones / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D011499:Protein Processing, Post-Translational
chemical_list: D002843:Chromatin; D006657:Histones