title: Identification of Paracoccidioides brasiliensis in adrenal glands biopsies of two patients with paracoccidioidomycosis and adrenal insufficiency.
abstract: The authors report two cases of adrenal insufficiency secondary to infiltration of the adrenal glands by Paracoccidioides brasiliensis. The first patient had been treated for a chronic multifocal form of paracoccidiodomycosis 11 years ago. The diagnosis of the mycosis was done simultaneous with that of the adrenal insufficiency in the second patient. In both patients the diagnosis was done by direct visualization of fungus in adrenal biopsies. They were treated with hormonal supplements and itraconazol by 12 and six months, without relapses during the follow-up period.
authors.affiliation: Universidad Pontificia Bolivariana, Medellín, Colombia. carlosagudelo@yahoo.com
authors.forename: Carlos Andrés
authors.initials: CA
authors.lastname: Agudelo
authors.forename: Carolina
authors.initials: C
authors.lastname: Muñoz
authors.forename: Alex
authors.initials: A
authors.lastname: Ramírez
authors.forename: Jonhairo
authors.initials: J
authors.lastname: Gutierrez
authors.forename: Santiago
authors.initials: S
authors.lastname: Velez
authors.forename: Juan Camilo
authors.initials: JC
authors.lastname: Perez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Velez
authors.forename: Angela María
authors.initials: AM
authors.lastname: Tobon
authors.forename: Angela
authors.initials: A
authors.lastname: Restrepo
mesh_terms: D000311:Adrenal Glands / Q000382:microbiology*; D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D005438:Fludrocortisone / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010228:Paracoccidioides / Q000302:isolation & purification*; D010229:Paracoccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D017964:Itraconazole; D005438:Fludrocortisone; D011241:Prednisone