title: Meta- and pooled analysis of GSTP1 polymorphism and lung cancer: a HuGE-GSEC review.
abstract: Lung cancer is the most common cancer worldwide. Polymorphisms in genes associated with carcinogen metabolism may modulate risk of disease. Glutathione S-transferase pi (GSTP1) detoxifies polycyclic aromatic hydrocarbons found in cigarette smoke and is the most highly expressed glutathione S-transferase in lung tissue. A polymorphism in the GSTP1 gene, an A-to-G transition in exon 5 (Ile105Val, 313A --> 313G), results in lower activity among individuals who carry the valine allele. The authors present a meta- and a pooled analysis of case-control studies that examined the association between this polymorphism in GSTP1 and lung cancer risk (27 studies, 8,322 cases and 8,844 controls and 15 studies, 4,282 cases and 5,032 controls, respectively). Overall, the meta-analysis found no significant association between lung cancer risk and the GSTP1 exon 5 polymorphism. In the pooled analysis, there was an overall association (odds ratio = 1.11, 95% confidence interval: 1.03, 1.21) between lung cancer and carriage of the GSTP1 Val/Val or Ile/Val genotype compared with those carrying the Ile/Ile genotype. Increased risk varied by histologic type in Asians. There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.
authors.affiliation: Population Studies and Prevention, Karmanos Cancer Institute, Internal Medicine, Wayne State University School of Medicine, 110 East Warren, Detroit, MI 48201, USA. cotem@med.wayne.edu
authors.forename: Michele L
authors.initials: ML
authors.lastname: Cote
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Daryn W
authors.initials: DW
authors.lastname: Smith
authors.forename: Simone
authors.initials: S
authors.lastname: Benhamou
authors.forename: Christine
authors.initials: C
authors.lastname: Bouchardy
authors.forename: Dorota
authors.initials: D
authors.lastname: Butkiewicz
authors.forename: Kwun M
authors.initials: KM
authors.lastname: Fong
authors.forename: Manuel
authors.initials: M
authors.lastname: Gené
authors.forename: Ari
authors.initials: A
authors.lastname: Hirvonen
authors.forename: Chikako
authors.initials: C
authors.lastname: Kiyohara
authors.forename: Jill E
authors.initials: JE
authors.lastname: Larsen
authors.forename: Pinpin
authors.initials: P
authors.lastname: Lin
authors.forename: Ole
authors.initials: O
authors.lastname: Raaschou-Nielsen
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Povey
authors.forename: Edyta
authors.initials: E
authors.lastname: Reszka
authors.forename: Angela
authors.initials: A
authors.lastname: Risch
authors.forename: Joachim
authors.initials: J
authors.lastname: Schneider
authors.forename: Ann G
authors.initials: AG
authors.lastname: Schwartz
authors.forename: Mette
authors.initials: M
authors.lastname: Sorensen
authors.forename: Jordi
authors.initials: J
authors.lastname: To-Figueras
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.forename: Yuepu
authors.initials: Y
authors.lastname: Pu
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Angela S
authors.initials: AS
authors.lastname: Wenzlaff
authors.forename: Harriet
authors.initials: H
authors.lastname: Wikman
authors.forename: Emanuela
authors.initials: E
authors.lastname: Taioli
mesh_terms: D044466:Asian People / Q000235:genetics; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012907:Smoking; D044465:White People / Q000235:genetics
chemical_list: D051549:Glutathione S-Transferase pi