Biomarkers in relation to cognitive reserve in patients with mild cognitive impairment--proof of concept.
BACKGROUND
The concept of the cognitive reserve (CR) posits that factors such as education enable compensation for the effect of brain pathology. Consequently, pathology should be more pronounced in individuals with higher CR before becoming clinically apparent. Biomarkers such as total tau (t-tau) and beta-amyloid 42 (Abeta42) may be surrogates for pathology in relation to CR in patients with neurodegenerative disease.


OBJECTIVE
To examine the applicability of biomarkers as surrogates for pathology in relation to the CR in patients with mild cognitive impairment (MCI) either converting to dementia or remaining stable at follow-up.


METHODS
Comparisons of baseline t-tau, Abeta42, educational years and global cognition for MCI patients either converting to dementia (n = 57) or remaining stable (n = 91) were made. Patients converting to dementia were grouped on the basis of educational level and compared considering biomarkers and neuropsychological tests.


RESULTS
Stable MCI patients were better educated, performed better cognitively, had higher Abeta42 levels and lower levels of t-tau. Converting MCI patients with higher education had lower levels of Abeta42 and performed equally in neuropsychological tests compared to those with lower education.


CONCLUSIONS
Our results suggest that highly educated MCI patients subsequently converting to dementia display more amyloid pathology.
Rolstad
S
S
Institute of Neuroscience and Physiology, Sahlgrenska Academy at Göteborg University, Mölndal, Sweden. sindre.rolstad@neuro.gu.se
Nordlund
A
A
Eckerström
C
C
Gustavsson
M H
MH
Zetterberg
H
H
Wallin
A
A
D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001288:Attention / Q000502:physiology; D015415:Biomarkers; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000235:genetics / Q000378:metabolism / Q000523:psychology*; D003704:Dementia / Q000523:psychology; D018450:Disease Progression; D004493:Education; D005260:Female; D006801:Humans; D007858:Learning / Q000502:physiology; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000378:metabolism; D011597:Psychomotor Performance / Q000502:physiology; D014796:Visual Perception / Q000502:physiology; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D015415:Biomarkers; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins