Tumor-associated macrophages and the related myeloid-derived suppressor cells as a paradigm of the diversity of macrophage activation.
Macrophages undergo a wide spectrum of polarized activation states, and have the potential both to elicit tumor and tissue destructive reactions and to promote tumor progression (macrophage balance). In general, tumor-associated macrophages (TAM) from established tumors and the related myeloid-derived suppressor cells are diverse and have properties of M2-activated cells. As such, they help cancer progression and metastasis. Therefore, TAM are a key component of pathways connecting inflammation and cancer.
Mantovani
Alberto
A
Istituto Clinico Humanitas IRCCS, Rozzano, Milan, Italy.
Sica
Antonio
A
Allavena
Paola
P
Garlanda
Cecilia
C
Locati
Massimo
M
D000818:Animals; D016207:Cytokines / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007110:Immunity, Active / Q000276:immunology; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000276:immunology* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000276:immunology* / Q000378:metabolism
D016207:Cytokines