Tolerance of oat-based topical products in cereal-sensitized adults with atopic dermatitis.
BACKGROUND
Few data suggest oat-based cosmetics may cause allergic reactions in atopic subjects, especially when sensitized to cereals.


OBJECTIVE
To evaluate the risk of immediate and delayed allergic reactions to repeated and maximized applications (RMA) of oat-containing cosmetics and oat extracts and their tolerance in cereal-sensitized atopic adults.


METHODS
Open-label pilot study in 12 cereal-sensitized atopic adults over 45 days. Open tests and RMA were performed with Rhealba oat-containing cosmetics at day 0 (D0) and D10, and from D10 to D31. Patch and prick tests were performed at D7 and D42 with wheat and Rhealba oat extracts and the study cream.


RESULTS
The RMA of oat-based cosmetics in cereal-sensitized atopic adults did not induce any immediate or delayed allergic reaction and was well tolerated. No immediate or delayed positive skin test to oat extracts was observed.


CONCLUSIONS
Sensitization to cereals does not increase the risk of allergic reactions to oat-containing cosmetics.
Goujon
Catherine
C
Unité de Recherche Clinique en Immunologie, Centre Hospitalier Lyon Sud, UFR Lyon-Sud, Université Lyon 1, Pierre Bénite, France.
Jean-Decoster
Catherine
C
Dahel
Karima
K
Bottigioli
David
D
Lahbari
Farida
F
Nicolas
Jean-François
JF
Schmitt
Anne-Marie
AM
D000328:Adult; D000485:Allergens / Q000276:immunology*; D018554:Avena / Q000276:immunology*; D003358:Cosmetics / Q000009:adverse effects*; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000276:immunology*; D002523:Edible Grain / Q000276:immunology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D007073:Immunoglobulin E / Q000097:blood; D007428:Intradermal Tests; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D021182:Wheat Hypersensitivity / Q000175:diagnosis; D055815:Young Adult
D000485:Allergens; D003358:Cosmetics; D007073:Immunoglobulin E