The utility of cardiopulmonary exercise testing in the assessment of suspected microvascular ischemia.
Evidence demonstrating the potential value of cardiopulmonary exercise testing (CPET) to accurately detect myocardial ischemia secondary to macro-vascular disease is beginning to emerge. Despite distinct mechanisms mediating ischemia in micro-vascular and macrovascular coronary artery disease (CAD), the net physiologic effect of exercise-induced left ventricular (LV) dysfunction is common to both. The abnormal physiologic response to CPET may, therefore, be similar in patients with macro- and micro-vascular ischemia. The following case report describes the CPET abnormalities in a patient with suspected microvascular CAD and the subsequent improvement in LV function following three weeks of medical therapy with the anti-ischemic drug ranolazine.
Chaudhry
Sundeep
S
Arena
Ross
R
Wasserman
Karlman
K
Hansen
James E
JE
Lewis
Gregory D
GD
Myers
Jonathan
J
Belardinelli
Romualdo
R
LaBudde
Brian
B
Menasco
Nicholas
N
Boden
William E
WE
D005080:Exercise Test / Q000379:methods / Q000706:statistics & numerical data*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000503:physiopathology*