Lower bone mineral density is associated with higher coronary calcification and coronary plaque burdens by multidetector row coronary computed tomography in pre- and postmenopausal women.
OBJECTIVE
There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this association.


METHODS
Eight hundred and fifteen subjects received routine checkups. After excluding subjects with factors affecting bone metabolism and cardiovascular disease, 467 subjects were analysed.


METHODS
Coronary calcification was measured with MDCT and BMD was measured with dual X-ray absorptiometry (DXA).


RESULTS
The BMD of the femur and the lumbar spine (L-spine) were negatively associated with the coronary calcium score (CCS) after adjusting for age in women but not in men. This inverse correlation was stronger in women with a longer time since menopause (r = -0.35 at femur, postmenopausal women vs. r = -0.10 at femur, premenopausal women, P < 0.05), and it was stronger at the femur than in the L-spine (r = -0.35 at femur vs. r = -0.16 at L-spine, P < 0.01). The relationship was also stronger in postmenopausal women with osteoporosis and osteopaenia than in women with normal BMD. The lower BMD was associated with higher coronary plaque burdens and multidiseased coronary vessels in both men and women (P < 0.01).


CONCLUSIONS
Increased CCS and subclinical atherosclerosis of plaque burdens as revealed by MDCT was associated with a low BMD in all women, independent of cardiovascular risk factors and age.
Choi
Sung Hee
SH
Seoul National University College of Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, Korea.
An
Jee Hyun
JH
Lim
Soo
S
Koo
Bo Kyung
BK
Park
Se Eun
SE
Chang
Hyuck Jae
HJ
Choi
Sang Il
SI
Park
Young Joo
YJ
Park
Kyong Soo
KS
Jang
Hak Chul
HC
Shin
Chan Soo
CS
D015519:Bone Density / Q000502:physiology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017698:Postmenopause / Q000378:metabolism*; D017697:Premenopause / Q000378:metabolism*; D014057:Tomography, X-Ray Computed