Hooked on the D3 receptor: CaMKII's new addiction.
The dopaminergic D3 receptor (D3R) is emerging as an antagonist of sensitized behavior induced by addictive drugs such as cocaine. New work by Wang and coworkers in this issue of Neuron now identifies CaMKII as an important negative regulator of the D3R. CaMKII relieves the D3R-mediated inhibition on sensitized behavior to foster drug-seeking behavior.
Hell
Johannes W
JW
Department of Pharmacology, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA. johannes-hell@uiowa.edu
D000818:Animals; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008032:Limbic System / Q000187:drug effects / Q000201:enzymology* / Q000503:physiopathology; D011485:Protein Binding / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D050637:Receptors, Dopamine D3 / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D019966:Substance-Related Disorders / Q000201:enzymology* / Q000503:physiopathology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D050637:Receptors, Dopamine D3; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D004298:Dopamine