Associations between HLA-C alleles and papillary thyroid carcinoma.
OBJECTIVE
Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of this study was to determine the association between HLA-C allele frequencies and papillary thyroid carcinoma in an Iranian population.


METHODS
HLA-Cw allele frequencies were determined in patients with papillary thyroid carcinoma (N = 54) and non-related healthy controls (N = 91) using PCR-SSP.


RESULTS
We found that HLACw4 and HLACw15 allele frequencies were significantly higher in our patients compared to the controls [P = 10-4, OR; 12.5, 95% CI 2.6-116.9) and [P = 10-4, OR; 24.7, 95% CI (3.6-1058) respectively].


CONCLUSIONS
Our results revealed certain HLA-C alleles are predisposing factors in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for association between HLA-C alleles and differentiated carcinomas in other populations.
Haghpanah
Vahid
V
Endocrinology and Metabolism Research Centre, University of Tehran/Medical Sciences, Tehran, Iran.
Khalooghi
Keinoosh
K
Adabi
Khadijeh
K
Amiri
Parvin
P
Tavangar
Seyed Mohammad
SM
Amirzargar
Ali
A
Ghaffari
Hamidollah
H
Yazdani
Nasrin
N
Nikbin
Behrooz
B
Larijani
Bagher
B
Amoli
Mahsa M
MM
D000328:Adult; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D011379:Prognosis; D012307:Risk Factors; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000235:genetics*
D015236:HLA-C Antigens