title: [Survival after radical prostatectomy in patients with prostate cancer and seminal vesicle invasion].
abstract: OBJECTIVE
  To assess the outcome of patients with clinically localized prostate cancer (PCa) and seminal vesicle invasion (SVI) in the radical prostatectomy (RP) specimen.
  
  
  METHODS
  212 patients with clinically localized PCa underwent RP at our institution from 1988 to 2007. SVI (stage pT3bNOMO of the TNM 2002 system) was demonstrated in 40 (18.9%).
  
  
  RESULTS
  Patients with SVI and PSA <10 ng/mL had better prognosis than those with a PSA > or =10 ng/mL, with a 5-year biochemical progression-free survival (bPFS) of 68.2% and 19.9%, respectively (p=0.008). In univariate analysis, an initial prostate specific antigen (PSA) > or =10 ng/mL (p=0.01) and preoperative high risk group (p=0.05) were related to the likelihood of biochemical failure. In multivariate analysis, only PSA remained independently associated to the risk of biochemical recurrence.
  
  
  CONCLUSIONS
  In the present study, the frequency of SVI was 18.9%. SVI confers a poor prognosis. Preoperative PSA > or =10 ng/mL was associated to the risk of biochemical recurrence.
authors.affiliation: Departamento de Urologia, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, DF México. rcastillejos@hotmail.com
authors.forename: Ricardo Alonso
authors.initials: RA
authors.lastname: Castillejos-Molina
authors.forename: Francisco
authors.initials: F
authors.lastname: Rodríguez-Covarrubias
authors.forename: Mariano
authors.initials: M
authors.lastname: Sotomayor de Zavaleta
authors.forename: Norma
authors.initials: N
authors.lastname: Uribe-Uribe
authors.forename: Leonardo Saúl
authors.initials: LS
authors.lastname: Lino
authors.forename: Guillermo
authors.initials: G
authors.lastname: Feria-Bernal
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012669:Seminal Vesicles / Q000473:pathology*; D016019:Survival Analysis