title: Update on therapeutic strategies to increase adiponectin function and secretion in metabolic syndrome.
abstract: Changes in diagnostic criteria have impacted on the definition of the metabolic syndrome. The central aetiological importance of insulin resistance has lessened, while the role of other cardiovascular risk factors has progressively increased. Inflammatory mediators have also been identified as crucial targets for more selective therapies in metabolic syndrome. Among several pro-inflammatory factors, adiponectin has been shown to be associated with reduced cardiovascular risk in metabolic syndrome patients. Here, we review new therapeutic approaches, which could potentially increase adiponectin levels in metabolic syndrome.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, Foundation for Medical Researches, Geneva University Hospital, Geneva, Switzerland.
authors.forename: F
authors.initials: F
authors.lastname: Montecucco
authors.forename: F
authors.initials: F
authors.lastname: Mach
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D063387:Cannabinoid Receptor Antagonists; D002318:Cardiovascular Diseases / Q000150:complications / Q000517:prevention & control; D002995:Clofibric Acid / Q000494:pharmacology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D007333:Insulin Resistance; D024821:Metabolic Syndrome / Q000150:complications / Q000188:drug therapy*; D051379:Mice; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists; D012307:Risk Factors
chemical_list: D052242:Adiponectin; D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D063387:Cannabinoid Receptor Antagonists; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D047492:Peroxisome Proliferator-Activated Receptors; D002995:Clofibric Acid