title: Synaptic vesicle endocytosis: get two for the price of one?
abstract: Tight coupling between synaptic vesicle exocytosis and endocytosis is critical for the maintenance of neurotransmission. In this issue of Neuron, Zhu et al. reveal a surprising facet of this coupling by showing that, at low frequencies, fusion of a single vesicle leads to retrieval of two vesicles with dissimilar attributes.
authors.affiliation: Department of Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390-9111, USA.
authors.forename: Chihye
authors.initials: C
authors.lastname: Chung
authors.forename: Ege T
authors.initials: ET
authors.lastname: Kavalali
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000648:ultrastructure; D004705:Endocytosis / Q000502:physiology*; D005456:Fluorescent Dyes; D006801:Humans; D008561:Membrane Fusion / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism; D017729:Presynaptic Terminals / Q000378:metabolism* / Q000648:ultrastructure; D013194:Staining and Labeling / Q000379:methods; D009435:Synaptic Transmission / Q000502:physiology*; D013572:Synaptic Vesicles / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D005456:Fluorescent Dyes; D009419:Nerve Tissue Proteins