title: Effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures in locally corticosteroid-induced Achilles tendinosis: an experimental study on rats.
abstract: BACKGROUND
  To determine the effects of human amniotic fluid and membrane in the treatment of Achilles tendon ruptures, 72 tendons of 36 Wistar rats were injected with betamethasone sodium phosphate.
  
  
  METHODS
  By the end of fourth week, both tendons were tenotomized and repaired, then the samples were divided into three groups. The first group was left untreated after suturing. Human amniotic fluid was injected to the second and amniotic fluid and membrane were both administered to the third group. Twenty-four tendons were scored at the end of the first week, and 24 at the end of the second week histopathologically, and 24 biomechanically at the end of the third week.
  
  
  RESULTS
  There was a significant statistical difference only between the histopathological results of Groups 2 and 3 at the first week.
  
  
  CONCLUSIONS
  Human amniotic membrane and fluid do not add anything to the healing process of Achilles tendon ruptures in the early phase.
authors.affiliation: Dokuz Eylül University, School of Medicine, Department of Orthopaedics and Traumatology, Izmir, Turkey.
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Coban
authors.forename: Ismail Safa
authors.initials: IS
authors.lastname: Satoğlu
authors.forename: Alper
authors.initials: A
authors.lastname: Gültekin
authors.forename: Burçin
authors.initials: B
authors.lastname: Tuna
authors.forename: Hasan
authors.initials: H
authors.lastname: Tatari
authors.forename: Mustafa
authors.initials: M
authors.lastname: Fidan
mesh_terms: D000125:Achilles Tendon / Q000293:injuries*; D000650:Amnion; D000653:Amniotic Fluid; D000818:Animals; D001623:Betamethasone / Q000008:administration & dosage / Q000031:analogs & derivatives; D003131:Combined Modality Therapy; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012421:Rupture / Q000628:therapy; D052256:Tendinopathy / Q000139:chemically induced / Q000150:complications*
chemical_list: D005938:Glucocorticoids; C028994:betamethasone sodium phosphate; D001623:Betamethasone