title: Review of statistical methodologies used to compare (bio)assays.
abstract: At any phase of the development of a drug or a vaccine, scientists need to compare different (bio)assays. The objective of this paper is to review different statistical methodologies that could be used to assess the equivalence between methods. Depending on the objective (average or individual equivalence), depending on the design, several approaches are detailed: two one-sided t-tests, concordance correlation coefficient, limits of agreement, tolerance intervals and probabilistic approach.
authors.affiliation: GSK Biologicals, Rue de l'Institut 89, B-1330 Rixensart, Belgium. walthere.dewe@scarlet.be
authors.forename: Walthère
authors.initials: W
authors.lastname: Dewé
mesh_terms: D001681:Biological Assay / Q000379:methods* / Q000706:statistics & numerical data*; D004353:Drug Evaluation, Preclinical / Q000379:methods / Q000706:statistics & numerical data; D012107:Research Design / Q000706:statistics & numerical data*; D013223:Statistics as Topic