Mini sensing chip for point-of-care acute myocardial infarction diagnosis utilizing micro-electro-mechanical system and nano-technology.
A rapid and accurate diagnosis of acute myocardial infarction (AMI) is crucial for saving lives. For this purpose, we have been developing a rapid, automatic, point-of-care, biosensing system for simultaneous four cardiac marker quantification. This system performs a fluorophore mediated immuno-sensing on optical fibers. To improve the sensitivity of the sensor, novel nanoparticle reagents enhancing fluorescence were implemented. Micro-electro-mechanical system (MEMS) technology was applied in the sensing chip development and automatic sensing operation was implemented to ensure a reliable and user-friendly assay. The resulting system is a point-of-care, automatic four cardiac marker sensing system with a 2 x 2.5 cm sensing chip. An assay requires a 200 microL plasma sample and 15-minute assay time.
Wang
Jianting
J
Department of Chemical Engineering, University of Louisville, Louisville, KY 40292, USA.
Hong
Bin
B
Kai
Junhai
J
Han
Jungyoup
J
Zou
Zhiwei
Z
Ahn
Chong H
CH
Kang
Kyung A
KA
D000208:Acute Disease; D015415:Biomarkers; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods*; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation* / Q000379:methods*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000378:metabolism; D036103:Nanotechnology / Q000295:instrumentation* / Q000379:methods*; D020097:Natriuretic Peptide, Brain / Q000032:analysis
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain