title: Input-state approach to Boolean networks.
abstract: This paper investigates the structure of Boolean networks via input-state structure. Using the algebraic form proposed by the author, the logic-based input-state dynamics of Boolean networks, called the Boolean control networks, is converted into an algebraic discrete-time dynamic system. Then the structure of cycles of Boolean control systems is obtained as compounded cycles. Using the obtained input-state description, the structure of Boolean networks is investigated, and their attractors are revealed as nested compounded cycles, called rolling gears. This structure explains why small cycles mainly decide the behaviors of cellular networks. Some illustrative examples are presented.
authors.affiliation: Institute of Systems Science, Chinese Academy of Sciences, Beijing 100190, China. dcheng@iss.ac.cn
authors.forename: Daizhan
authors.initials: D
authors.lastname: Cheng
mesh_terms: D000465:Algorithms; D005796:Genes / Q000502:physiology*; D008128:Logic; D016571:Neural Networks, Computer; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011506:Proteins