title: Molecular evidence that the range of the Vancouver Island outbreak of Cryptococcus gattii infection has expanded into the Pacific Northwest in the United States.
abstract: Cryptococcus neoformans frequently causes fungal meningitis in immunocompromised patients, whereas the related species C. gattii is restricted to tropical and subtropical regions,where it usually infects immunocompetent individuals.An outbreak of C. gattii infection that began in 1999 on Vancouver Island has resulted in endemic C. gattii infection and caused numerous human and veterinary infections; the outbreak's range has spread to mainland British Columbia. The outbreak-related isolates have been molecular type VGIIa, the major genotype, or VGIIb, the minor genotype. Since 2006, human and veterinary cases of C. gattii infection have emerged in Washington and Oregon. Multilocus sequence typing demonstrates the spread of C. gattii VGIIa and VGIIb from Vancouver Island to the Pacific Northwest. Clinical strains recovered in Oregon represent a unique VGIIc genotype.
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Edmond J
authors.initials: EJ
authors.lastname: Byrnes
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Bildfell
authors.forename: Sheryl A
authors.initials: SA
authors.lastname: Frank
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Mitchell
authors.forename: Kieren A
authors.initials: KA
authors.lastname: Marr
authors.forename: Joseph
authors.initials: J
authors.lastname: Heitman
mesh_terms: D000818:Animals; D001955:British Columbia / Q000453:epidemiology; D003453:Cryptococcosis / Q000453:epidemiology* / Q000382:microbiology / Q000662:veterinary; D003454:Cryptococcus / Q000145:classification* / Q000235:genetics; D004196:Disease Outbreaks; D005838:Genotype; D006801:Humans; D017720:Molecular Epidemiology; D015205:Northwestern United States / Q000453:epidemiology