The multilayer regulation of the metaphase-to-anaphase transition.
The fluctuating activity of the cyclin-dependent kinases (Cdks) is critical for the periodic phosphorylation of a given Cdk substrate. Previous studies have been focus on the positive role of Cdk-dependent protein phosphorylation in cell cycle progression. Recent studies indicate that, in budding yeast, highly active S-phase cyclin-associated Cdk not only promotes DNA synthesis but also inhibits the initiation of chromosome segregation. The FEAR (Cdc14 early anaphase release) pathway alleviates the negative effect of the S-phase cyclin on anaphase by promoting the dephosphorylation of S-phase cyclin-specific substrates, revealing a new layer of regulation in the metaphase-to-anaphase transition.
Jin
Fengzhi
F
Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida 32306-4300, USA.
Richmond
Daniel
D
Wang
Yanchang
Y
D000705:Anaphase; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D020090:Chromosome Segregation; D018844:Cyclin-Dependent Kinases / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D008677:Metaphase; D008938:Mitosis; D008954:Models, Biological; D010766:Phosphorylation; D016196:S Phase; D004718:Saccharomycetales / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; D018844:Cyclin-Dependent Kinases