title: Fitting techniques of cell survival curves in high-dose region for use in stereotactic body radiation therapy.
abstract: Stereotactic body radiation therapy (SBRT) uses high doses of radiation to treat tumors. The cell survival behavior at these high doses is subject to debate. We investigated this high-dose region by fitting a variety of formulas to cell survival data. Each of the formulas is motivated by a discussion of the theory of cell survival. Fourteen cell lines are examined. These are fit to a variety of equations. Among the equations include the traditional single-hit multi-target and linear quadratic as well as recent proposals such as the universal survival curve (USC). The chi(2)/df of each fit is compared to determine the best fit. While no formula is clearly superior for all cell lines, the newer formulas often provide better fits than the single-hit multi-target and linear quadratic. We recommend that the more recent formula discussed herein be used over the linear quadratic in dealing with the high-dose regions dealt with in SBRT.
authors.affiliation: Department of Radiation Oncology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
authors.forename: F W
authors.initials: FW
authors.lastname: McKenna
authors.forename: S
authors.initials: S
authors.lastname: Ahmad
mesh_terms: D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D008954:Models, Biological; D011829:Radiation Dosage; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage