title: Association between clinical activity and high-resolution tomography findings in pulmonary Wegener's granulomacytosis.
abstract: Wegener's granulomatosis is characterized histologically by necrotizing granulomatous angitis that most commonly involves the upper, lower respiratory tract, and kidneys, but may affect any organ system. The aim of the study was to assess the usefulness of high-resolution computed tomography (HRCT) for evaluating pulmonary disease activity in Wegener's granulomatosis patients. Pulmonary disease activity at the time of examination was scored in 66 patients with Wegener's granulomatosis according to clinical, radiological, and bronchoscopic findings: activity group (n=43, Group 1), past activity group (n=14, Group 2). Of 66 staging examinations, 57 (86%) revealed abnormal CT scans: masses or nodules (30 patients in Group 1 and 6 patients in Group 2, parenchymal opacifications (15 in Group 1 and 1 in Group 2), pleural irregularity (3 in Group 1 and 10 in Group 2). We conclude that HRCT may be a useful supplement to clinical scoring of disease activity in Wegener's granulomatosis with pulmonary involvement.
authors.affiliation: Primary Systemic Vasculitis Outpatient Clinic, Department of Family Medicine, Internal and Metabolic Diseases, Nephrology Unit, Warsaw Medical University, Warsaw, Poland. kzycinska@poczta.fm.
authors.forename: K
authors.initials: K
authors.lastname: Zycinska
authors.forename: K A
authors.initials: KA
authors.lastname: Wardyn
authors.forename: Z
authors.initials: Z
authors.lastname: Zycinski
authors.forename: T M
authors.initials: TM
authors.lastname: Zielonka
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000378:metabolism; D001772:Blood Cell Count; D001999:Bronchoscopy; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000097:blood / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D002097:C-Reactive Protein