Tooth loss and osteoporosis: the OSTEODENT Study.
OBJECTIVE
To determine the cross-sectional association of the osteoporotic status of patients with the number of their teeth, with and without taking into account age and/or smoking.


METHODS
At four centres, the study recruited 665 females aged 45-70 years and the number of teeth was counted for 651 subjects. Bone density was measured at the total hip, femoral neck and lumbar spine.


RESULTS
The mean number of teeth in the osteoporotic subjects was 3.3 fewer than normal subjects and 2.1 fewer if those with no teeth were excluded. The association between osteoporosis and having <6 or having <28 teeth remained significant after adjusting for age, smoking and centre with p-values of 0.016 and 0.011, respectively. A single regression model for tooth count with normal errors would not fit all the data. By fitting mixture regression models to subjects with tooth count >0, three clusters were identified corresponding to different degrees of tooth loss. The overall effect of osteoporosis was as follows: -1.8 teeth before and after adjusting for smoking, -1.2 teeth after adjusting for age, and -1.1 teeth after adjusting for both age and smoking.


CONCLUSIONS
We have established a significant association between osteoporosis and tooth loss after adjusting the effect for age and smoking.
Nicopoulou-Karayianni
Kety
K
Dental School, University of Athens, Athens, Greece.
Tzoutzoukos
Panagiotis
P
Mitsea
Anastasia
A
Karayiannis
Athanasios
A
Tsiklakis
Kostas
K
Jacobs
Reinhilde
R
Lindh
Christina
C
van der Stelt
Paul
P
Allen
Philip
P
Graham
Jim
J
Horner
Keith
K
Devlin
Hugh
H
Pavitt
Susan
S
Yuan
Jingsong
J
D015502:Absorptiometry, Photon; D017677:Age Distribution; D000368:Aged; D015519:Bone Density; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D007568:Jaw / Q000000981:diagnostic imaging; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications*; D011862:Radiography, Panoramic; D012907:Smoking; D016388:Tooth Loss / Q000150:complications*