title: Intravesical electromotive drug administration of mitomycin-C for non-muscle invasive bladder cancer.
abstract: This article reviews intravesical application of electromotive drug administration (EMDA) for the treatment of bladder cancer and the evidence in support of intravesical passive diffusion chemotherapy in the management of non-muscle invasive bladder cancer. Two recently published randomised trials adopting protocols that use EMDA to enhance urothelial transport of intravesical mitomycin-C showed it provided a therapeutical advantage and suggested that intravesical passive diffusion administration of chemotherapeutic drugs may be suboptimal. Further studies are required to demonstrate feasibility and advantage of intravesical EMDA of mitomycin-C in the wider uro-oncological community.
authors.affiliation: Tor Vergata University, Department of Surgery/Urology, Rome, Italy. sdistas@tin.it
authors.forename: Savino M
authors.initials: SM
authors.lastname: Di Stasi
authors.forename: Emanuele
authors.initials: E
authors.lastname: Liberati
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Dutto
authors.forename: Cristian
authors.initials: C
authors.lastname: Verri
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D053672:Electrochemotherapy; D006801:Humans; D016685:Mitomycin / Q000008:administration & dosage*; D009361:Neoplasm Invasiveness; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin