title: The expression and clinical significance of TGF-beta1 and MMP2 in human renal clear cell carcinoma.
abstract: The expression and clinical significance of transforming growth factor beta1 (TGF-beta1) and matrix metalloproteinase-2 (MMP2) in human renal clear cell carcinoma (RCCC) were investigated. The intensity of TGF-beta1 and MMP2 expression in RCCC kidneys was significantly higher than that in normal kidneys. Expression of TGF-beta1 and MMP2 in RCCC tissues was positively correlated with pathological grade and clinical stage. There was also a significant correlation between TGF-beta1 and Msshese analyses indicate that upregulation of TGF-beta1 and MMP2 expression may occur during the progression of RCCC. Thus, TGF-beta1 and MMP2 may be useful molecular markers for evaluating prognosis in RCCC patients.
authors.affiliation: Department of Pathology, Wuxi People's Hospital, Nanjing Medical University, Wuxi, Jiangsu, People's Republic of China. ysd-zh@163.com
authors.forename: Shu-Dong
authors.initials: SD
authors.lastname: Yang
authors.forename: Rong-Chao
authors.initials: RC
authors.lastname: Sun
authors.forename: Hui-Jun
authors.initials: HJ
authors.lastname: Mu
authors.forename: Zhuo-Qun
authors.initials: ZQ
authors.lastname: Xu
authors.forename: Zhi-Yi
authors.initials: ZY
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002681:China / Q000453:epidemiology; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D007668:Kidney / Q000473:pathology / Q000601:surgery; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D015996:Survival Rate; D053773:Transforming Growth Factor beta1 / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D012333:RNA, Messenger; D053773:Transforming Growth Factor beta1; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2