title: Selective tuning of the right inferior frontal gyrus during target detection.
abstract: In the human brain, a network of frontal and parietal regions is commonly recruited during tasks that demand the deliberate, focused control of thought and action. Previously, using a simple target detection task, we reported striking differences in the selectivity of the BOLD response in anatomically distinct subregions of this network. In particular, it was observed that the right inferior frontal gyrus (IFG) followed a tightly tuned function, selectively responding only to the current target object. Here, we examine this functional specialization further, using adapted versions of our original task. Our results demonstrate that the response of the right IFG to targets is a strong and replicable phenomenon. It occurs under increased attentional load, when targets and distractors are equally frequent, and when controlling for inhibitory processes. These findings support the hypothesis that the right IFG responds selectively to those items that are of the most relevance to the currently intended task schema.
authors.affiliation: Cambridge University, Cambridge, England. adam.hampshire@mrc-cbu.cam.ac.uk
authors.forename: Adam
authors.initials: A
authors.lastname: Hampshire
authors.forename: Russell
authors.initials: R
authors.lastname: Thompson
authors.forename: John
authors.initials: J
authors.lastname: Duncan
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Owen
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001288:Attention; D001931:Brain Mapping; D005625:Frontal Lobe / Q000098:blood supply / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010364:Pattern Recognition, Visual; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology*; D017603:Signal Detection, Psychological / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen