Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones.
A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, beta-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.
Liu
Chen-Jiang
CJ
School of Science, Xi'an Jiaotong University, Xi'an, PR China. cjliuxj@126.com
Wang
Ji-De
JD
D000085:Acetates / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D015394:Molecular Structure; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry*; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry; D014508:Urea / Q000737:chemistry
D000085:Acetates; D000447:Aldehydes; D011744:Pyrimidinones; D013451:Sulfonic Acids; D013871:Thiones; D003300:Copper; D014508:Urea; C005741:sulfamic acid