Catecholamine-secreting neuroblastoma in a 4-month-old infant: perioperative management.
Preoperative alpha- and beta-adrenergic receptor block with phenoxybenzamine and labetalol, the intraoperative course of a 4-month-old infant with neuroblastoma and elevated catecholamines causing sweating, hypertension, and tachycardia, are presented. We recommend determination of catecholamine levels and pretreatment with alpha-adrenergic and--if needed--beta-adrenergic receptor antagonists in infants with neuroblastoma and hypertension, tachycardia, or sweating.
Hernandez
Michael R
MR
Department of Anesthesiology, Perioperative, and Pain Medicine, Children's Hospital Boston, Boston, MA 02115, USA. mhernandez@dacc.uchicago.edu
Shamberger
Robert C
RC
Seefelder
Christian
C
D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007223:Infant; D007741:Labetalol / Q000627:therapeutic use*; D009447:Neuroblastoma / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D019990:Perioperative Care / Q000379:methods; D010643:Phenoxybenzamine / Q000627:therapeutic use*; D013546:Sweating; D013610:Tachycardia / Q000209:etiology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D002395:Catecholamines; D010643:Phenoxybenzamine; D007741:Labetalol