[Preparation and thermo-sensitivity behavior of polymer liposomes made of poly(2-ethylacrylic acid) alkylamide derivatives].
The temperature-sensitive liposomes were constructed by poly (2-ethylacrylic acid) (PEAA) alkylamide derivatives that were synthesized for partially modification of carboxylic groups. The thermal characteristics of liposomes were investigated by using fluorescent indicator, particle size device and fluorescence spectrophotometer system. The results showed that the liposome made of fatty amine-modified poly(2-ethylacrylate) had a marked thermal sensitive release of drugs, which is correlated with the structure of molecular of polymer and the initial ratio of composition of phospholipid. The PEAA-associated-liposomes were also shown pH-sensitive drug release under acidic condition. The poly (2-ethylacrylate) for the preparation of medium-induced thermal liposomes in vitro experiments showed a good thermal characteristics and the methods of preparing temperature-sensitive liposomes were convenient and stability.
Wang
Zhao
Z
Faculty of Life Sciences, Northwestern Polytechnical University, Xi' an 710072, China.
Chen
Tao
T
Wang
Ru-tao
RT
Wang
Wei-jiao
WJ
Hui
Min-quan
MQ
D000179:Acrylates / Q000737:chemistry*; D002784:Cholesterol / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D005452:Fluoresceins / Q000032:analysis; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013696:Temperature
D000179:Acrylates; D004337:Drug Carriers; D005452:Fluoresceins; D008081:Liposomes; D010713:Phosphatidylcholines; D011108:Polymers; C091381:poly(2-ethylacrylic acid); D002784:Cholesterol; C010942:1,2-distearoyllecithin; C007740:fluorexon