title: Interleukin-4 as a neuromodulatory cytokine: roles and signaling in the nervous system.
abstract: Although interleukin (IL)-4 is described as a prototypical anti-inflammatory cytokine, in recent years its role as a neuromodulatory cytokine has been extensively discussed. This review highlights the pivotal contributions of IL-4 during the development and normal physiology of neural cells as well as IL-4 connections with the pathophysiology of degenerative or inflammatory processes observed in the central and peripheral nervous system.
authors.affiliation: Instituto de Biofísica Carlos Chagas Filho, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil. asholl@biof.ufrj.br
authors.forename: Alfred
authors.initials: A
authors.lastname: Sholl-Franco
authors.forename: Ana Gabriela Ledo Santos
authors.initials: AG
authors.lastname: da Silva
authors.forename: Juliana
authors.initials: J
authors.lastname: Adão-Novaes
mesh_terms: D000818:Animals; D004194:Disease; D006801:Humans; D015847:Interleukin-4 / Q000378:metabolism*; D009420:Nervous System / Q000378:metabolism* / Q000473:pathology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D019948:Receptors, Interleukin-4 / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D018377:Neurotransmitter Agents; D019948:Receptors, Interleukin-4; D015847:Interleukin-4