title: Synthesis, lipophilicity and antimicrobial activity of new derivatives of thiosemicarbazides and 1,2,4-triazoline-5-thione.
abstract: In the reaction of hydrazide of 3,4-dimethoxyphenylacetic acid (1) with isothiocyanate the respective thiosemicarbazide derivatives (2) were obtained. Further cyclization with 2% NaOH led to the formation of 3-[(3,4-dimethoxyphenyl)methyl]-4-substituted-1,2,4-triazoline-5-thiones (3). The structures of all new products were confirmed by analytical and spectroscopic methods. All compounds were screened for their in vitro activity against some species of aerobic bacteria and fungi. The lipophilicity of the synthesized molecules was also studied.
authors.affiliation: Department of Organic Chemistry, Medical University, 6 Staszica St., 20-081 Lublin, Poland. monika.wujec@am.lublin.pl
authors.forename: Monika
authors.initials: M
authors.lastname: Wujec
authors.forename: Joanna
authors.initials: J
authors.lastname: Stefańska
authors.forename: Agata
authors.initials: A
authors.lastname: Siwek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Tatarczak
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001420:Bacteria, Aerobic / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D057927:Hydrophobic and Hydrophilic Interactions; D012663:Semicarbazides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D012663:Semicarbazides; D013871:Thiones; D014230:Triazoles; C005151:thiosemicarbazide