title: [Correlation between T lymphoma invasion and metastasis 1 expression and epithelial-mesenchymal transition in human colorectal carcinomas].
abstract: OBJECTIVE
  To investigate the relationship between T lymphoma invasion and metastasis 1 (Tiam1) and epithelial-mesenchymal transition (EMT) in human colorectal carcinomas.
  
  
  METHODS
  Tiam1, E-cadherin, CK, and vimentin expressions in normal colorectal epithelium, colorectal carcinomas (CRC) and CRC with lymphatic metastasis were determined by immunohistochemistry using a two-step method.
  
  
  RESULTS
  Tiam1 expression was significantly higher in CRC than in normal colorectal epithelium (P<0.01) in close correlation to the degree of tumor differentiation (P<0.05). Higher Tiam1 expression was detected in CRC with lymphatic metastasis than in primary CRC (P<0.05). The expressions of E-cadherin and CK in CRC tissues were significantly lowered in comparison with those in normal colorectal epithelium (P<0.01), showing a correlation to tumor differentiation (P<0.01) but not to lymphatic metastasis. Vimentin was significantly overexpressed in CRC (P<0.01) and correlated to tumor differentiation (P<0.01) but not to lymphatic metastasis. Tiam1 expression was inversely correlated to E-cadherin and CK, but positively to vimentin.
  
  
  CONCLUSIONS
  Tiam1 is related to the metastasis of colorectal carcinoma, and may induce EMT to promote CRC metastasis.
authors.affiliation: Department of Pathology, Institute of Digestive Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. hujie0000@163.com
authors.forename: Jie
authors.initials: J
authors.lastname: Hu
authors.forename: Ya-dong
authors.initials: YD
authors.lastname: Wang
authors.forename: Yu-fa
authors.initials: YF
authors.lastname: Li
authors.forename: Ya-juan
authors.initials: YJ
authors.lastname: Wang
authors.forename: Hui-xia
authors.initials: HX
authors.lastname: Han
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D002465:Cell Movement / Q000502:physiology; D054338:Cell Transdifferentiation / Q000235:genetics / Q000502:physiology*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D004847:Epithelial Cells / Q000473:pathology*; D005260:Female; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007633:Keratins / Q000235:genetics / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1; D055815:Young Adult
chemical_list: D015820:Cadherins; D020662:Guanine Nucleotide Exchange Factors; D000075684:T-Lymphoma Invasion and Metastasis-inducing Protein 1; C087334:TIAM1 protein, human; D007633:Keratins