Telencephalic organization in the spotted African Lungfish, Protopterus dolloi: a new cytological model.
Recent studies have greatly increased our knowledge of telencephalic organization in ray-finned fishes and terrestrial vertebrates, particularly amphibians. In contrast, little new information has been generated on telencephalic organization in lobe-finned fishes. The coelacanth, Latimeria, and three genera of lungfishes constitute the living lobe-finned fishes. Latimeria is extremely rare and critically endangered, so the living lungfishes, therefore, offer the only feasible source of new information on telencephalic organization in lobe-finned fishes. A re-examination of the cytoarchitectonics of the telencephalon in the Spotted African Lungfish has allowed the generation of a new model of telencephalic organization in lungfishes. To begin to test this model, examination was made of the telencephalic distribution of acetylcholinesterase, enkephalin, the neurotensin-related hexapeptide LANT6, nitric oxide synthase (nicotinamide adenine dinucleotide phosphate-diaphorase), substance P, and tyrosine hydroxylase. This distribution supports the new model and suggests that the medial pallial-subpallial border, the striatopallidal systems, and the amygdalar organization in this lungfish are more similar to these features in terrestrial vertebrates than was previously suspected.
Northcutt
R Glenn
RG
Laboratory of Comparative Neurobiology, Scripps Institution of Oceanography and Department of Neurosciences, School of Medicine, University of California, San Diego, La Jolla, Calif., USA. rgnorthcutt@ucsd.edu
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D004745:Enkephalins / Q000378:metabolism; D005399:Fishes / Q000378:metabolism*; D007150:Immunohistochemistry; D008959:Models, Neurological; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism; D010784:Photomicrography; D013373:Substance P / Q000378:metabolism; D013687:Telencephalon / Q000033:anatomy & histology / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D004745:Enkephalins; D009842:Oligopeptides; D013373:Substance P; C037243:neurotensin-related hexapeptide; D019001:Nitric Oxide Synthase; D014446:Tyrosine 3-Monooxygenase; D000110:Acetylcholinesterase