Nickel-catalyzed synthesis of oxazoles via C-S activation.
The synthesis of 2-substituted oxazoles is achieved via nickel-catalyzed cross-coupling reaction of 2-methylthio-oxazole and various organozinc reagents. An extension of this method is demonstrated with a chemoselective, one-pot synthesis of unsymmetrical 2,5-disubstituted oxazoles. This synthesis of 2- and 2,5-substituted oxazoles using this method provides great advantages over previous methods for these compounds and is highly complementary to current cyclodehydration strategies.
Lee
Kyoungsoo
K
Evans Chemical Laboratories, Department of Chemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, USA.
Counceller
Carla M
CM
Stambuli
James P
JP
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry
D010080:Oxazoles; D009532:Nickel