title: 3D MDCT-based system for planning peripheral bronchoscopic procedures.
abstract: The diagnosis and staging of lung cancer often begins with the assessment of a suspect peripheral chest site. Such suspicious peripheral sites may be solitary pulmonary nodules or other abnormally appearing regions of interest (ROIs). The state-of-the-art process for assessing such peripheral ROIs involves off-line procedure planning using a three-dimensional (3D) multidetector computed tomography (MDCT) chest scan followed by bronchoscopy with an ultrathin bronchoscope. We present an integrated computer-based system for planning peripheral bronchoscopic procedures. The system takes a 3D MDCT chest image as input and performs nearly all operations automatically. The only interaction required by the physician is the selection of ROI locations. The system is computationally efficient and fits smoothly within the clinical work flow. Integrated into the system and described in detail in the paper is a new surface-definition method, which is vital for effective analysis and planning to peripheral sites. Results demonstrate the efficacy of the system and its usage for the live guidance of ultrathin bronchoscopy to the periphery.
authors.affiliation: Department of Electrical Engineering, Penn State University, University Park, PA 16802, USA.
authors.forename: Jason D
authors.initials: JD
authors.lastname: Gibbs
authors.forename: Michael W
authors.initials: MW
authors.lastname: Graham
authors.forename: William E
authors.initials: WE
authors.lastname: Higgins
mesh_terms: D001331:Automation; D001999:Bronchoscopy / Q000379:methods*; D003201:Computers; D003936:Diagnosis, Computer-Assisted / Q000295:instrumentation*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D008953:Models, Anatomic; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D012984:Software; D013499:Surface Properties; D014057:Tomography, X-Ray Computed / Q000379:methods*