title: [Histomorphology of angiogenesis patterns in different areas of human astrocytomas].
abstract: OBJECTIVE
  To study angiogenesis patterns in the edematous area and the center of human astrocytomas by histological observation, and to reveal histological basis of vasculogenic mimicry.
  
  
  METHODS
  Tissue samples were drawn from the tumor center and the edematous area in 51 patients with human astrocytomas during operation MR and were examined by CD34 endothelial marker periodic acid-Schiff (PAS) dual staining.
  
  
  RESULTS
  Vessels or capillaries stained by both PAS and CD34 were found in edematous areas of human astrocytomas. Besides vessels or capillaries stained by both PAS and CD34, vasculogenic mimicries (PAS-positive and CD34-negative tubes containing red blood cells and lined by neoplastic cells), PAS-positive and CD34-negative tubes containing red blood cells and without cells around, PAS-positive and partial CD34-positive vessels or capillaries, and PAS-positive and CD34-negtive vessels or capillaries were detected in the center of tumor of 4 human glioblastomas.
  
  
  CONCLUSIONS
  Vasculogenic mimicries in the center of some high-grade astrocytomas may be caused by blood capillary dysplasia, while angiogenesis patterns are vessels or capillaries in the edematus area and the center of most human astrocytomas.
authors.affiliation: Department of Neurosurgery, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China. hwmai@sina.com
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Song-tao
authors.initials: ST
authors.lastname: Qi
authors.forename: Zhi-wang
authors.initials: ZW
authors.lastname: Guo
authors.forename: Ke-wan
authors.initials: KW
authors.lastname: Wang
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Liu
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis; D001254:Astrocytoma / Q000098:blood supply* / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001929:Brain Edema / Q000209:etiology / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology*; D055815:Young Adult
chemical_list: D018952:Antigens, CD34