title: Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma: a case report.
abstract: A rare case of post-radiation epithelioid hemangioendothelioma arising in a congenital hemangioma of the lower leg 18 years after radiotherapy is reported. At 7 years of age, the patient underwent partial resection of a subcutaneous congenital hemangioma with intramuscular extension of the left lower leg, and at 10 years of age, the patient was given radiotherapy with a total dose of 30 Gy for recurrence. At 28 years of age, the patient noticed a large tumor mass with intractable pain at the antero-lateral aspect of the proximal lower leg, and she presented to our hospital. Since microscopic examination of a biopsy specimen showed epithelioid hemangioendothelioma, disarticulation at the knee joint was performed. Although malignant change in a benign vascular tumor is extremely rare, irradiation can induce malignant transformation of a hemangioma.
authors.affiliation: Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan.
authors.forename: Rui
authors.initials: R
authors.lastname: Niimi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Matsumine
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kusuzaki
authors.forename: Ken
authors.initials: K
authors.lastname: Shintani
authors.forename: Tomoki
authors.initials: T
authors.lastname: Nakamura
authors.forename: Hideki
authors.initials: H
authors.lastname: Kotera
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Murata
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
mesh_terms: D000328:Adult; D004188:Disarticulation; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D006391:Hemangioma / Q000151:congenital* / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D007719:Knee Joint / Q000601:surgery; D008279:Magnetic Resonance Imaging; D010146:Pain / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D013977:Tibia / Q000000981:diagnostic imaging / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome