Effects of moxibustion pretreating on SOD and MDA in the rat of global brain ischemia.
OBJECTIVE
To probe into the mechanism of moxibustion preconditioning in preventive brain-protecting effect.


METHODS
The global brain ischemia rat model was developed by blocking 4 arteries. Seventy-eight Wistar male rats were randomly divided into 5 groups: a normal control group, a sham-operation group, a brain ischemia group, a brain ischemia preconditioning group, a moxibustion pretreating group. The brains in the 5 groups were taken at 24 h, 48 h, and 72 h after operation respectively. Superoxide dismulase (SOD) activity was determined with xanthine oxidase method and malondialdehyde (MDA) content with thiobarbituric acid method.


RESULTS
After the operation, in the moxibustion preconditioning group, SOD activity significantly increased, especially 24 h after moxibustion preconditioning; and MDA content decreased, with a very significant difference as compared with that of the cerebral ischemia group (P<0.01).


CONCLUSIONS
Moxibustion preconditioning protects the ischemic and anoxic brain tissue by increasing the activity of endogenous antioxidase.
Hua
Jin-shuang
JS
Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China.
Li
Li-ping
LP
Zhu
Xian-min
XM
D000818:Animals; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002545:Brain Ischemia / Q000378:metabolism* / Q000517:prevention & control* / Q000628:therapy; D006801:Humans; D019194:Ischemic Preconditioning; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D009071:Moxibustion; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
D008315:Malondialdehyde; D013482:Superoxide Dismutase