title: A new gliotoxin analogue from a marine-derived fungus Aspergillus fumigatus Fres.
abstract: A new gliotoxin analogue (1), as well as four known compounds gliotoxin (2), bisdethiobis (methylthio) gliotoxin (3), bis-N-norgliovictin (4) and didehydrobisdethiobis (methylthio) gliotoxin (5), were isolated from a culture of marine-derived fungus Aspergillus fumigatus Fres. The structure of 1 was determined on the basis of spectroscopic methods. All five compounds were evaluated for the cytotoxic effects on tsFT210 cell line by the SRB method.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education, Marine Drugs and Food Institute, Ocean University of China, Qingdao, China.
authors.forename: Wen Ying
authors.initials: WY
authors.lastname: Zhao
authors.forename: Tian Jiao
authors.initials: TJ
authors.lastname: Zhu
authors.forename: Xiao Xian
authors.initials: XX
authors.lastname: Han
authors.forename: Guo Tao
authors.initials: GT
authors.lastname: Fan
authors.forename: Hong Bing
authors.initials: HB
authors.lastname: Liu
authors.forename: Wei Ming
authors.initials: WM
authors.lastname: Zhu
authors.forename: Qian
authors.initials: Q
authors.lastname: Qun Gu
mesh_terms: D000818:Animals; D001232:Aspergillus fumigatus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005912:Gliotoxin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure
chemical_list: D005912:Gliotoxin