title: Mesenchymal stem cell allograft in revision foot and ankle surgery: a clinical and radiographic analysis.
abstract: A review was conducted of 23 patients who underwent implantation of mesenchymal stem cell allograft for revision foot or ankle surgery. Composed of viable mesenchymal stem cells derived from cadaveric donor tissue, the graft had osteogenic, osteoinductive, and osteoconductive properties, and was capable of direct new bone formation at the site of implantation. In all of the cases, radiographic new bone formation was observed at the area of implantation and a 91.3% union rate was observed, and no evidence of graft rejection or complications associated with implantation were recorded. Wilcoxon rank sum tests were used to determine whether gender, diabetes, chronic renal insufficiency, neuropathy, number of previous surgeries, and smoking were associated with time to healing. Spearman's rank correlation coefficient was calculated in an effort to identify the influence of continuous numeric variables on the time to bone healing. Based on the outcomes observed in this retrospective study, it appears that mesenchymal stem cell allograft is a beneficial biological adjunct to bone healing, and serves as a suitable bone autograft substitute in revision foot and ankle surgery.
  
  
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authors.affiliation: Department of Orthopedics and Podiatric Surgery, The Palo Alto Medical Foundation, Mountain View, CA 94040, USA. Rushdoc@gmail.com
authors.forename: Shannon M
authors.initials: SM
authors.lastname: Rush
authors.forename: Graham A
authors.initials: GA
authors.lastname: Hamilton
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Ackerson
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000842:Ankle / Q000601:surgery*; D005260:Female; D005528:Foot / Q000601:surgery*; D006801:Humans; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D008875:Middle Aged; D019651:Plastic Surgery Procedures; D012086:Reoperation; D014184:Transplantation, Homologous; D055815:Young Adult