Structural and temporal regulation of centromeric chromatin.
Normal inheritance of genetic material requires that chromosomes segregate faithfully during mitosis and meiosis. The kinetochore is a unique structure that attaches chromosomes to the microtubule spindle, monitors proper chromosome attachment to the spindle through the mitotic checkpoint, and couples spindle and motor protein forces to move chromosomes during prometaphase and anaphase. The centromere is a specialized chromosomal site that is the structural and functional foundation for kinetochore formation, and is characterized by a unique type of chromatin that needs to be reconstituted after each replication cycle. In this review, recent progress in understanding the structural nature of this chromatin and how it is specifically maintained through cell division are discussed.
Mellone
Barbara G
BG
Department of Genome and Computational Biology, Lawrence Berkeley National Laboratory, and Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA 94720, USA. barbara.mellone@uconn.edu
D000818:Animals; D002503:Centromere / Q000378:metabolism*; D002843:Chromatin / Q000737:chemistry* / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D044127:Epigenesis, Genetic; D006801:Humans; D009687:Nuclear Proteins / Q000378:metabolism; D013997:Time Factors
D002843:Chromatin; D009687:Nuclear Proteins; D004247:DNA