title: Lymphoepithelioma-like carcinoma of the uterine cervix.
abstract: OBJECTIVE
  To elucidate the clinicopathologic features of lymphoepithelioma-like carcinoma (LELC) of the uterine cervix, we examined three Japanese cases.
  
  
  METHODS
  We collected three cases of LELC of the uterine cervix between 2000 and 2007. We examined these patients' clinicopathologic data, Epstein-Barr virus (EBV) and human papilloma virus (HPV) infectious status, and infiltrated lymphocyte population.
  
  
  RESULTS
  Our patients had disease Fédération Internatinale de Gynécologie et d'Obstétrique stages I and II. All of them were free of disease at the time of the study. Macroscopically, one of the three tumors was polypoid. All tumor cells were negative for EBV and HPV using in situ hybridization and immunohistochemistry. The inflammatory background contained many CD3(+) and CD8(+) cells, but there were few CD4(+), CD20(+), or CD79a(+) cells.
  
  
  CONCLUSIONS
  In our Japanese series, LELC of the uterine cervix showed good prognosis, and there is no relationship between this carcinoma and EBV or HPV infection.
authors.affiliation: Department of Obstetrics and Gynecology, Oita Prefectural Hospital, Oita, Japan. takai@med.oita-u.ac.jp
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Takai
authors.forename: Satoru
authors.initials: S
authors.lastname: Nakamura
authors.forename: Kiyomi
authors.initials: K
authors.lastname: Goto
authors.forename: Chihiro
authors.initials: C
authors.lastname: Hayashita
authors.forename: Naoko
authors.initials: N
authors.lastname: Kira
authors.forename: Shogo
authors.initials: S
authors.lastname: Urabe
authors.forename: Hisashi
authors.initials: H
authors.lastname: Narahara
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsumoto
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology* / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000473:pathology / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000473:pathology / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000821:virology