A transferable 20-kilobase multiple drug resistance-conferring R plasmid (pKL0018) from a fish pathogen (Lactococcus garvieae) is highly homologous to a conjugative multiple drug resistance-conferring enterococcal plasmid.
Lactococcus garvieae, the causative agent of lactococcosis, has evolved strains that are highly resistant to antibiotics. Here, the 20,034-bp sequence of L. garvieae conjugative plasmid pKL0018 was determined. It contained two ermB genes and one tetS gene and a backbone more than 96% identical to that of pRE25, an Enterococcus faecalis plasmid from dry sausage.
Maki
Takeshi
T
Laboratory of Genome Science, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato-ku, Tokyo 108-8477, Japan.
Santos
Mudjekeewis D
MD
Kondo
Hidehiro
H
Hirono
Ikuo
I
Aoki
Takashi
T
D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000235:genetics*; D023061:Gene Order; D005798:Genes, Bacterial; D017045:Lactococcus / Q000187:drug effects* / Q000235:genetics*; D008969:Molecular Sequence Data; D010957:Plasmids; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D026801:Synteny
D004269:DNA, Bacterial