Free radical lipid peroxidation during amiodarone therapy for postinfarction cardiosclerosis.
Postinfarction remodeling of the heart in animals with myocardial infarction was accompanied by activation of lipid peroxidation in myocardial tissue and blood serum and decrease in antioxidant enzyme activity. In animals with postinfarction cardiosclerosis treated with amiodarone, we observed decreased accumulation of lipid peroxidation products and normalization of superoxide dismutase activity.
Rebrova
T Yu
TY
Institute of Cardiology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. rebrova@cardio.tsu.ru
Afanasyev
S A
SA
D000638:Amiodarone / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D005609:Free Radicals / Q000378:metabolism; D015227:Lipid Peroxidation / Q000502:physiology*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012598:Sclerosis
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D005609:Free Radicals; D000638:Amiodarone