Detection of single-nucleotide mismatches using scanning electrochemical microscopy.
Probing ds-DNA films in the presence of Zn(2+) ions by scanning electrochemical microscopy (SECM) allows the unequivocal detection of a single-nucleotide mismatch and provides information about its position within the duplex.
Diakowski
Piotr Michal
PM
Department of Chemistry, The University of Western Ontario, 1151 Richmond Street, London, Ontario, CanadaN6A 5B7.
Kraatz
Heinz-Bernhard
HB
D020137:Base Pair Mismatch; D004563:Electrochemistry; D008855:Microscopy, Electron, Scanning / Q000379:methods*; D009711:Nucleotides / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
D009711:Nucleotides; D015032:Zinc