title: Quality of life in patients with systemic sclerosis compared to the general population and patients with other chronic conditions.
abstract: OBJECTIVE
  Systemic sclerosis (SSc) affects multiple physical, psychological, and social domains and is associated with impaired health-related quality of life (HRQOL).We compared the HRQOL of SSc patients with individuals in the general population and patients with other common chronic diseases.
  
  
  METHODS
  HRQOL of SSc patients in the Canadian Scleroderma Research Group registry was measured using version 2 of the Medical Outcomes Trust Short Form-36 (SF-36). Results were compared to US general population norms and scores reported for patients with other common chronic diseases, namely heart disease, lung disease, hypertension, diabetes, and depression.
  
  
  RESULTS
  SF-36 scores were available for 504 SSc patients (86% women, mean age 56 yrs, mean disease duration since onset of first non-Raynaud's manifestation of SSc 11 yrs). The greatest impairment in SF-36 subscale scores appeared to be in the physical functioning, general health, and role physical domains. SF-36 subscale and summary scores in SSc were significantly worse compared to US general population norms for women of similar ages, except for mental health and mental component summary score, which were not significantly different, and were generally comparable to or worse than the scores of patients with other common chronic conditions.
  
  
  CONCLUSIONS
  HRQOL of patients with SSc is significantly impaired compared to that of the general population and is comparable to or worse than that of patients with other common chronic conditions.
authors.affiliation: SMBD-Jewish General Hospital and McGill University, Room A-216, 3755 Cote Ste. Catherine Road, Montreal, Quebec H3T 1E2, Canada. marie.hudson@mcgill.ca
authors.forename: Marie
authors.initials: M
authors.lastname: Hudson
authors.forename: Brett D
authors.initials: BD
authors.lastname: Thombs
authors.forename: Russell
authors.initials: R
authors.lastname: Steele
authors.forename: Pantelis
authors.initials: P
authors.lastname: Panopalis
authors.forename: Evan
authors.initials: E
authors.lastname: Newton
authors.forename: Murray
authors.initials: M
authors.lastname: Baron
mesh_terms: D002908:Chronic Disease; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D011788:Quality of Life; D012595:Scleroderma, Systemic / Q000503:physiopathology / Q000523:psychology; D011795:Surveys and Questionnaires