Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population.
Obesity is a major public health problem characterized with high body mass index (BMI). Copy number variations (CNVs) have been identified to be associated with complex human diseases. The effect of CNVs on obesity is unknown. In this study, we explored the association of CNVs with BMI in 597 Chinese Han subjects using Affymetrix GeneChip Human Mapping 500K Array Set. We found that one CNV at 10q11.22 (from 46.36 Mb to 46.56 Mb) was associated with BMI (the raw P=0.011). The CNV contributed 1.6% of BMI variation, and it covered one important obesity gene-pancreatic polypeptide receptor 1(PPYR1). It was reported that PPYR1 was a key regulator of energy homeostasis. Our findings suggested that CNV might be potentially important for the BMI variation. In addition, our study suggested that CNV might be used as a genetic marker to locate genes associated with BMI in Chinese population.
Sha
Bao-Yong
BY
Laboratory of Molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and Developmental Biology of Ministry of Education, College of Life Sciences, Hunan Normal University, Changsha, Hunan, PR China.
Yang
Tie-Lin
TL
Zhao
Lan-Juan
LJ
Chen
Xiang-Ding
XD
Guo
Yan
Y
Chen
Yuan
Y
Pan
Feng
F
Zhang
Zhi-Xin
ZX
Dong
Shan-Shan
SS
Xu
Xiang-Hong
XH
Deng
Hong-Wen
HW
D000368:Aged; D044466:Asian People / Q000235:genetics*; D015992:Body Mass Index; D002681:China; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics; D056915:DNA Copy Number Variations / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male