Pleiotropic effects of amitriptyline ameliorate renal fibrosis.
Unilateral ureteral obstruction is a well-established model of renal fibrosis used by many investigators to test various compounds for their ability to ameliorate kidney disease. Achar et al. treated ureterally obstructed mice with the tricyclic antidepressant amitriptyline and found that this inhibited inflammation, myofibroblast formation, and several other indices of renal fibrosis. This pleiotropic antidepressant agent appears to have antifibrotic effects in the kidney and other organ systems.
Morrissey
Jeremiah J
JJ
Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110-1093, USA. morrisse@wustl.edu
D000639:Amitriptyline / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D005347:Fibroblasts / Q000187:drug effects; D005355:Fibrosis / Q000188:drug therapy*; D007249:Inflammation / Q000517:prevention & control; D007674:Kidney Diseases / Q000473:pathology*; D051379:Mice
D000639:Amitriptyline