title: Immunogenetics of seasonal influenza vaccine response.
abstract: Seasonal influenza causes significant morbidity, mortality, and economic costs. Vaccines against influenza, though both safe and effective, are imperfect. Notably, these vaccines result in significant immune response variability across the population. The mechanism for this variability, in part, appears to lie in the polymorphisms of key immune response genes. Despite the importance of this variability, little in the way of genetic polymorphisms and its association with vaccine immune response to viral vaccines has been performed. Herein, we review and synthesize what is known about the immune response pathway and influenza viral immunity and then present original data from our laboratory on the immunogenetic relationships between HLA, cytokine and cytokine receptor gene polymorphisms and the variations in humoral immune response to inactivated seasonal influenza vaccine. Finally, we propose that a better understanding of vaccine immunogenetics offers insight towards the development of better influenza vaccines.
authors.affiliation: Mayo Vaccine Research Group, The Program in Translational Immunovirology and Biodefense, Mayo Clinic, 611C Guggenheim Building, 200 First Street, SW, Rochester, MN 55905, USA. poland.gregory@mayo.edu
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Poland
authors.forename: Inna G
authors.initials: IG
authors.lastname: Ovsyannikova
authors.forename: Robert M
authors.initials: RM
authors.lastname: Jacobson
mesh_terms: D000917:Antibody Formation / Q000235:genetics*; D005802:Genes, MHC Class II; D006801:Humans; D007111:Immunity, Cellular / Q000235:genetics*; D007252:Influenza Vaccines / Q000276:immunology*; D007251:Influenza, Human / Q000517:prevention & control*; D011110:Polymorphism, Genetic
chemical_list: D007252:Influenza Vaccines