Ultrastructural signs of cyclophosphamide-induced damage to cardiomyocytes.
Ultrastructural changes in rat cardiomyocytes were studied after single administration of cyclophosphamide in the therapeutic dose. The major signs of cyclophosphamide-induced damage to cardiomyocytes included moderate lysis of myofibrils, dilation of vesicles in the granular and agranular sarcoplasmic reticulum, and destruction of mitochondria with the formation of myelin-like residual bodies. Ultrastructural changes in cardiomyocyte nuclei primarily manifested in variations of the shape, deep invaginations of the nuclear membrane, and translocation into the subsarcolemmal region.
Lushnikova
E L
EL
Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru
Nepomnyashchikh
L M
LM
Sviridov
E A
EA
Klinnikova
M G
MG
D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D008297:Male; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000648:ultrastructure; D009210:Myofibrils / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats; D017208:Rats, Wistar
D003520:Cyclophosphamide