title: Other therapies for reducing low-density lipoprotein cholesterol: medications in development.
abstract: Although the past 30 years have been fruitful and productive in lipid research, from basic science to drug development to demonstration of clinical benefit, cardiovascular disease remains the major cause of mortality and morbidity in industrialized societies. With the rapid industrialization of countries, such as India and China, cardiovascular disease rapidly is becoming the leading cause of global death and disability. Although most of the effective lipid-lowering drugs, the statins, have become generic and inexpensive, there remains a need for effective and safe agents. Hopefully, some of those discussed in this article will fill that need.
authors.affiliation: Metabolic and Atherosclerosis Research Center, 4685 Forest Avenue, Cincinnati, OH, USA. esteinmrl@aol.com
authors.forename: Evan A
authors.initials: EA
authors.lastname: Stein
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001055:Apolipoproteins B / Q000235:genetics; D002352:Carrier Proteins / Q000037:antagonists & inhibitors; D002791:Cholesterol, Dietary / Q000037:antagonists & inhibitors / Q000378:metabolism; D008078:Cholesterol, LDL / Q000037:antagonists & inhibitors* / Q000097:blood*; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008077:Lipoproteins, LDL / Q000037:antagonists & inhibitors* / Q000097:blood*; D016376:Oligonucleotides, Antisense / Q000627:therapeutic use; D043484:Proprotein Convertases / Q000037:antagonists & inhibitors
chemical_list: D000924:Anticholesteremic Agents; D001055:Apolipoproteins B; D002352:Carrier Proteins; D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D016376:Oligonucleotides, Antisense; C106092:microsomal triglyceride transfer protein; D013186:Farnesyl-Diphosphate Farnesyltransferase; D043484:Proprotein Convertases