Pentoxifylline response in alloxan-induced diabetic rats.
CONCLUSIONS
This study in rats shows that pentoxifylline may reverse detrimental effects of diabetes mellitus (DM) on the auditory system.


OBJECTIVE
To investigate whether delayed auditory brainstem responses (ABRs) induced by DM improve following pentoxifylline treatment in rats.


METHODS
Baseline ABRs were recorded in 25 ears of 13 normal-hearing rats. DM was induced by a single injection of alloxan (75 mg/kg of body weight) in all rats. Following a 1-month diabetic period, ABRs were recorded in six diabetic rats. Then, pentoxifylline treatment was administered for 6 weeks (20 mg/kg in drinking water), and final ABR testing was performed. Absolute latencies of waves I, III and V, and inter-peak latency differences (IPL) of I-V were measured in each stage of the experiment. These parameters were compared to each other in a pair-wise manner.


RESULTS
All wave latencies and IPL I-V were prolonged following induction of DM. Delay in waves III and V, and IPL I-V was significant (p<0.05). Pentoxifylline improved all of the wave latencies and IPL I-V, but significant improvement was observed in waves III and V (p<0.05). There was no significant difference between baseline measurements and measurements following pentoxifylline treatment.
Satar
Bulent
B
ORL Head & Neck Surgery, Gülhane Military Medical Faculty, Ankara, Turkey. bulentsatar@yahoo.com
Yildiz
Oguzhan
O
Karatas
Erkan
E
Boydag
Serkan
S
Akkaya
Abdullah
A
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D006319:Hearing Loss, Sensorineural / Q000209:etiology / Q000503:physiopathology; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; D010431:Pentoxifylline