title: [Expression of heparin-binding epidermal growth factor-like growth factor in patients with gastric carcinoma].
abstract: OBJECTIVE
  To investigate the expression of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in patients with gastric carcinoma in different stages.
  
  
  METHODS
  The expressions of HB-EGF protein and mRNA in normal gastric tissues, metaplasic intestinal mucosa, early-stage gastric cancer and advanced-stage gastric cancer tissues were detected by immunohistochemistry and in situ hybridization.
  
  
  RESULTS
  HB-EGF expression was only detected in the parietal cells of the gastric fundic glands and in gastrin cells of the pyloric glands in normal gastric tissues. Weak HB-EGF expression was detected in the epithelial cells of the gastric mucosa in intestinal metaplasic mucosa, and the expression increased in all layers of the gastric mucosa in early-stage gastric cancer. Intense HB-EGF expression was observed in advanced gastric cancer.
  
  
  CONCLUSIONS
  Increased HB-EGF expression may be implicated in the pathogenesis and development of gastric carcinoma.
authors.affiliation: Department of General Surgery, People's Hospital of Shaanxi Province, Xi'an 710068, China. wangguorong66@126.com
authors.forename: Guo-rong
authors.initials: GR
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Xiang-ming
authors.initials: XM
authors.lastname: Che
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Wang
authors.forename: Xaio-wei
authors.initials: XW
authors.lastname: Wang
authors.forename: Cheng-en
authors.initials: CE
authors.lastname: Pan
authors.forename: Wen-xian
authors.initials: WX
authors.lastname: He
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D014407:Tumor Cells, Cultured
chemical_list: C587883:HBEGF protein, human; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger