Lycojapodine A, a novel alkaloid from Lycopodium japonicum.
Lycojapodine A, a novel C(16)N-type Lycopodium alkaloid with an unprecedented 6/6/6/7 tetracyclic ring system, was isolated from the club moss Lycopodium japonicum. The structure and relative stereochemistry were elucidated on the basis of spectroscopic data and were further confirmed by X-ray analysis. A possible biosynthetic pathway for 1 was proposed. Its inhibitory activity on acetylcholinestrease and anti-HIV-1 activity were also evaluated.
He
Juan
J
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650204, People's Republic of China.
Chen
Xuan-Qin
XQ
Li
Ming-Ming
MM
Zhao
Yu
Y
Xu
Gang
G
Cheng
Xiao
X
Peng
Li-Yan
LY
Xie
Min-Jin
MJ
Zheng
Yong-Tang
YT
Wang
Yi-Ping
YP
Zhao
Qin-Shi
QS
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D032502:Lycopodium / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000494:pharmacology
D000470:Alkaloids; D019380:Anti-HIV Agents; D002800:Cholinesterase Inhibitors; D004365:Drugs, Chinese Herbal; D012717:Sesquiterpenes; C539671:lycojapodine A; C050426:huperzine A