title: Maternal smoking during pregnancy and testicular cancer in the sons: a nested case-control study and a meta-analysis.
abstract: Some large ecological studies have noted a significant association of testicular cancer (TC) with maternal smoking during pregnancy, while several more controlled studies have been negative. It has been difficult to obtain reliable data on exposure because of the long lag time to cancer diagnosis. We performed a case-control study nested within Finnish, Swedish and Icelandic maternity cohorts exploiting early pregnancy serum samples to evaluate the role of maternal smoking in the risk of TC in the offspring. After reviewing the literature, we also performed a meta-analysis of published studies. For each index mother of the TC patient, three to nine matched control mothers with a cancer-free son born at the same time as the TC case were identified within each cohort. First trimester sera were retrieved from the 70 index mothers and 519 control mothers and were tested for cotinine level by a novel HPLC-MS-MS method developed. No statistically significant association between maternal cotinine level and risk of TC in the offspring was found (OR 0.68; 95% CI 0.35, 1.34). This is the first study based on individual exposure measurements. Its results agree with our meta-analysis of seven previous epidemiological studies (total number of 2149 cases, 2762 controls) using indirect exposure assessment (OR 1.0; 95% CI 0.88, 1.12).
authors.affiliation: Department of Environmental Health, THL (National Institute for Health and Welfare, Formerly National Public Health Institute), P. O. Box 95, Kuopio FI-70701, Finland. jouko.tuomisto@ktl.fi
authors.forename: Jouko
authors.initials: J
authors.lastname: Tuomisto
authors.forename: Katsiaryna
authors.initials: K
authors.lastname: Holl
authors.forename: Panu
authors.initials: P
authors.lastname: Rantakokko
authors.forename: Pentti
authors.initials: P
authors.lastname: Koskela
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Göran
authors.initials: G
authors.lastname: Wadell
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Joakim
authors.initials: J
authors.lastname: Dillner
authors.forename: Helga M
authors.initials: HM
authors.lastname: Ogmundsdottir
authors.forename: Terttu
authors.initials: T
authors.lastname: Vartiainen
authors.forename: Matti
authors.initials: M
authors.lastname: Lehtinen
authors.forename: Eero
authors.initials: E
authors.lastname: Pukkala
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003367:Cotinine / Q000097:blood; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012907:Smoking / Q000097:blood / Q000453:epidemiology*; D013736:Testicular Neoplasms / Q000196:embryology / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D003367:Cotinine