Synthesis of 3-substituted-4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with amines.
A novel synthesis of 3-substituted 4(3H)-quinazolinones via HATU-mediated coupling of 4-hydroxyquinazolines with primary amines has been developed. Under mild reaction conditions, the products were achieved in good yield from commercially available starting materials.
Xiao
Zili
Z
Research & Development, Bristol-Myers Squibb Company, Princeton, New Jersey 08543, USA.
Yang
Michael G
MG
Li
Peng
P
Carter
Percy H
PH
D000588:Amines / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry
D000588:Amines; D052999:Quinazolinones