Association of serum fetuin A with truncal obesity and dyslipidemia in non-diabetic hemodialysis patients.
BACKGROUND
Fetuin A, a predictor of cardio-vascular (CV) mortality in dialysis patients has been associated with dyslipidemia in non-diabetic coronary artery disease. Truncal obesity is linked to dyslipidemia and also predicts CV mortality. This study had aimed to investigate the associations among fetuin A, truncal obesity, and dyslipidemia in hemodialysis (HD) patients.


METHODS
One hundred and nine non-diabetic HD patients were evaluated. Waist circumference, highly sensitive C-reactive protein (hs-CRP), fetuin A, and lipoprotein levels (i.e. total cholesterol (T-CHO), low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), non-HDL-C, and triglyceride (TG)) were measured for analysis of correlations. The patients were divided into tertiles by fetuin A concentrations.


RESULTS
Data from 63 women and 46 men aged 60+/-13 years were analyzed. Patients in the highest tertile of fetuin A (0.33-0.51 g/l) had higher serum creatinine, albumin, T-CHO, LDL-C, non-HDL-C, and TG, more truncal obesity and lower hs-CRP than patients in the lowest tertile (all P<0.05). In multi-variable linear regression analysis, fetuin A was independently associated with TG level and total iron binding capacity after adjustments for age, hemoglobin, albumin, calcium, body mass index, and hs-CRP. Patients in the highest fetuin A tertile had 3.2- and 4.4-fold higher incidence of truncal obesity (P=0.038) and hyper-triglyceridemia (P=0.015) independent of nutritional status and inflammation.


CONCLUSIONS
Fetuin A is positively associated with truncal obesity and dyslipidemia, which are independent of malnutrition and inflammation. It may predict visceral adiposity and dyslipidemia, especially TG and TG-rich lipoproteins, in HD patients.
Chen
Hung-Yuan
HY
Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, 21, Nan-Ya S. Road, Sec.2 Pan-Chiao, Taipei 200, Taiwan ROC.
Chiu
Yen-Lin
YL
Hsu
Shih-Ping
SP
Pai
Mei-Fen
MF
Lai
Chun-Fu
CF
Peng
Yu-Sen
YS
Kao
Tze-Wah
TW
Hung
Kuan-Yu
KY
Tsai
Tun-Jun
TJ
Wu
Kwan-Dun
KD
D000005:Abdomen / Q000473:pathology; D000368:Aged; D001798:Blood Proteins / Q000032:analysis* / Q000502:physiology; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D006435:Renal Dialysis / Q000706:statistics & numerical data; D051437:Renal Insufficiency / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000628:therapy; D013909:Thorax / Q000473:pathology; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D008074:Lipoproteins; D014280:Triglycerides; D060749:alpha-2-HS-Glycoprotein