Mature miR-184 and squamous cell carcinoma of the tongue.
Human microRNA 184 (miR-184) is overexpressed in squamous cell carcinoma (SCC) of the tongue. In vitro inhibition of miR-184 levels could induce apoptosis and hinder proliferation of tongue SCC cells. Patients with tongue SCC have high plasma miR-184 levels. Plasma miR-184 is likely associated with the tumor load. Surgical removal of the primary tumor reduced plasma miR-184 levels significantly. The data suggested that miR-184 is linked to the pathogenesis of tongue SCC. Further studies are warranted to evaluate the use of microRNA-based serological markers in monitoring tongue SCC.
Wong
Thian-Sze
TS
Department of Surgery, Faculty of Medicine, The University of Hong Kong. thiansze@graduate.hku.hk
Ho
Wai-Kuen
WK
Chan
Jimmy Yu-Wai
JY
Ng
Raymond Wai-Man
RW
Wei
William Ignace
WI
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D014062:Tongue Neoplasms / Q000235:genetics*
C534424:MIRN184 microRNA, human; D035683:MicroRNAs