The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications.
Human pathologies such as vascular malformations, hemorrhagic stroke, and edema have been associated with defects in the organization of endothelial cell junctions. Understanding the molecular basis of these diseases requires different integrated approaches which include basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish. In this review we discuss recent findings derived from these approaches and their possible integration in a common picture.
Dejana
Elisabetta
E
IFOM, The FIRC Institute of Molecular Oncology, Milan, Italy. elisabetta.dejana@ifom-ieo-campus.it
Tournier-Lasserve
Elisabeth
E
Weinstein
Brant M
BM
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001665:Binding Sites; D015820:Cadherins / Q000378:metabolism; D002199:Capillary Permeability; D000242:Cyclic AMP / Q000378:metabolism; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D010641:Phenotype; D015398:Signal Transduction; D020827:rap1 GTP-Binding Proteins / Q000378:metabolism; D000099152:Cadherin 5
D015703:Antigens, CD; D015820:Cadherins; D000242:Cyclic AMP; D020827:rap1 GTP-Binding Proteins; D000099152:Cadherin 5