title: [Safety and efficacy of weekly paclitaxel followed by FEC100 as primary systemic therapy for breast cancer].
abstract: The efficacy and safety of primary systemic therapy with weekly paclitaxel (wPTX; 80 mg/m2) followed by FEC100 (cyclophosphamide 500 mg/m2, epirubicin 100 mg/m2, 5-fluorouracil 500 mg/m2)were investigated in 52 patients with stage I-III A locally advanced breast cancer. Clinical response was complete in 30 patients (58%) and partial in 19 patients (37%). Pathological complete response was found in 23 primary lesions and 17 sentinel and/or sampling lymph nodes. No patients developed progressive disease and major adverse events except for febrile neutropenia in ten patients. These results showed that primary systemic therapy with wPTX followed by FEC100 is a feasible therapeutic option for breast cancer.
authors.affiliation: Dept. of Thoracic and Cardiovascular Surgery, Wakayama Medical University.
authors.forename: Koma
authors.initials: K
authors.lastname: Naito
authors.forename: Shoji
authors.initials: S
authors.lastname: Oura
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yoshimasu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Tamaki
authors.forename: Fuminori
authors.initials: F
authors.lastname: Ohta
authors.forename: Rie
authors.initials: R
authors.lastname: Nakamura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Megumi
authors.initials: M
authors.lastname: Kiyoi
authors.forename: Yoshimistu
authors.initials: Y
authors.lastname: Hirai
authors.forename: Miwako
authors.initials: M
authors.lastname: Miyasaka
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Okamura
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use*; D015251:Epirubicin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015251:Epirubicin; D003520:Cyclophosphamide; D017239:Paclitaxel; D005472:Fluorouracil