[Morphological features of chronic viral hepatitis C in drug abusers].
The morphological features of chronic viral hepatitis C were studied on specimens from 33 autopsy cases of heroinomania. A comparison group was presented with liver biopsy specimens taken in 17 cases corresponding to those of the study drug non-abusers diagnosed as having chronic viral hepatitis C. Chronic viral hepatitis C in drug abusers as compared to drug non-abusers was characterized by more pronounced hepatocytic dystrophic changes, less significant inflammatory infiltration of the portal tracts, a higher incidence of cholestasis with reactive changes in the epithelium of the biliary tract, fibrosis of the central venous walls. On immunohistochemical detection of hepatitis C virus NS3 antigen, an immunohistochemical reaction was less evident in the drug-abusers than in non-abusers, which showed the less replicative activity of hepatitis C virus in the liver of drug-abusers, which was caused by pronounced hepatocytic dystrophic changes and secondary immunodeficiency.
Makarova
O V
OV
Kanibolotskiĭ
A A
AA
Lun'kova
L K
LK
D000293:Adolescent; D000328:Adult; D001659:Biliary Tract / Q000473:pathology; D055030:Drug Users; D005260:Female; D016174:Hepacivirus / Q000201:enzymology; D019698:Hepatitis C, Chronic / Q000150:complications / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology; D008103:Liver Cirrhosis / Q000473:pathology / Q000821:virology; D008297:Male; D011169:Portal Vein / Q000473:pathology; D019966:Substance-Related Disorders / Q000150:complications / Q000473:pathology*; D017361:Viral Nonstructural Proteins / Q000378:metabolism; D055815:Young Adult; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases