title: Understanding and testing risk mechanisms for mental disorders.
abstract: Over the past 50 years there has been a virtual revolution in thinking about risk mechanisms. The key areas of challenge and opportunity include: identification of environmental causes; use of natural experiments; gene-environment interaction; testing for mediation; developmental moderation; biological programming; and developmental perturbations.
authors.affiliation: Institute of Psychiatry, London, UK. j.wickham@iop.kcl.ac.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Rutter
mesh_terms: D002648:Child; D004777:Environment; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000175:diagnosis* / Q000235:genetics* / Q000523:psychology; D012307:Risk Factors