Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids.
BACKGROUND
Keloids are a common problem with significant recurrence rates despite intralesional steroid treatment and multimodal therapy.


OBJECTIVE
The purpose of this study was to evaluate the efficacy of using a 5-fluorouracil (5-FU)/steroid mixture to treat keloids over the past 7 years, comparing the results with use of steroid treatment alone.


METHODS
Patient charts from 1999 to 2006 were reviewed. Patients were stratified into 3 groups: (1) 5-FU/steroid without excision; (2) 5-FU/steroid with excision; and (3) steroid treatment with excision. The percentage of lesion size reduction and symptoms were evaluated.


RESULTS
A total of 102 keloids were identified in a retrospective review. Patients who underwent the 5-FU/steroid combination with excision had a 92% average reduction in lesion size compared with 73% in the group of patients who did not receive 5-FU. Patients who received 5-FU/steroid without excision had an average lesion size reduction of 81%. Differences in complication rates were not statistically significant.


CONCLUSIONS
Combination 5-FU/triamcinolone is superior to intralesional steroid therapy in the treatment of keloids.
Davison
Steven P
SP
sDepartment of Plastic Surgery, Georgetown University Hospital, Washington, DC 20007, USA. pd2@gunet.georgetown.edu
Dayan
Joseph H
JH
Clemens
Mark W
MW
Sonni
Smitha
S
Wang
Antai
A
Crane
Amy
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy / Q000379:methods; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D015552:Injections, Intralesional / Q000379:methods; D007627:Keloid / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage*
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D014221:Triamcinolone; D005472:Fluorouracil