title: Pre-mRNA processing reaches back to transcription and ahead to translation.
abstract: The pathway from gene activation in the nucleus to mRNA translation and decay at specific locations in the cytoplasm is both streamlined and highly interconnected. This review discusses how pre-mRNA processing, including 5' cap addition, splicing, and polyadenylation, contributes to both the efficiency and fidelity of gene expression. The connections of pre-mRNA processing to upstream events in transcription and downstream events, including translation and mRNA decay, are elaborate, extensive, and remarkably interwoven.
authors.affiliation: Howard Hughes Medical Institute, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA. melissa.moore@umassmed.edu
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Moore
authors.forename: Nick J
authors.initials: NJ
authors.lastname: Proudfoot
mesh_terms: D000818:Animals; D005246:Feedback; D005786:Gene Expression Regulation; D006801:Humans; D014176:Protein Biosynthesis; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D020871:RNA Stability; D014158:Transcription, Genetic
chemical_list: D012322:RNA Precursors