Rhodium(I)-catalyzed cyclization reaction of o-alkynyl phenols and anilines. Domino approach to 2,3-disubstituted benzofurans and indoles.
A rhodium-catalyzed cyclization of o-alkynylphenols and anilines followed by intermolecular conjugate addition that succeeds with alkyl and aryl alkynes is reported. In this reaction, 2,3-disubstituted benzofurans or indoles are obtained in one pot in good to excellent yields.
Isono
Naohiro
N
Davenport Research Laboratories, Department of Chemistry, University of Toronto, Toronto, Ontario, Canada M5S 3H6.
Lautens
Mark
M
D000480:Alkynes / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D000814:Aniline Compounds; D001572:Benzofurans; D007211:Indoles; D010636:Phenols; D012238:Rhodium