title: [Evaluation of a new automatic CPAP algorithm in the treatment of obstructive sleep apnoea syndrome].
abstract: BACKGROUND
  Automatic continuous positive airway pressure (automatic CPAP, APAP) is an effective treatment option in the obstructive sleep apnoea syndrome (OSAS). The differentiation of obstructive and central respiratory events is crucial in adjusting the optimal pressure in this treatment mode. In this pilot study we evaluated a new automatic CPAP algorithm in OSAS patients.
  
  
  METHODS
  14 patients with newly diagnosed obstructive sleep apnoea syndrome were enrolled. After a diagnostic polysomnography, patients were treated for one night with a new APAP device based on flow, snoring, relative minute volume and the obstructive pressure peak signal.
  
  
  RESULTS
  The total apnoea/hypopnoea index (AHI) was 30.0 +/- 21.4/h at baseline and 3.7 +/- 5.3/h with APAP ( P < 0.005). Both obstructive AHI (22.7 +/- 20.5/h at baseline, 1.5 +/- 3.5/h with APAP, P < 0.005) and central AHI (7.3 +/- 4.9/h and 2.2 +/- 2.5/h, respectively, P < 0.01) as well as the arousal index (25.4 +/- 18.1/h and 5.1 +/- 3.8/h, respectively, P < 0.005) were reduced significantly with the new algorithm.
  
  
  CONCLUSIONS
  The new algorithm of an automatic CPAP device is effective in the treatment of obstructive sleep apnoea syndrome.
authors.affiliation: Krankenhaus Bethanien Solingen, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf- und Beatmungsmedizin, Universität Witten/Herdecke, 42699 Solingen. galetke@klinik-bethanien.de
authors.forename: W
authors.initials: W
authors.lastname: Galetke
authors.forename: S
authors.initials: S
authors.lastname: Stieglitz
authors.forename: N
authors.initials: N
authors.lastname: Anduleit
authors.forename: M
authors.initials: M
authors.lastname: Kenter
authors.forename: J
authors.initials: J
authors.lastname: Kühnel
authors.forename: R
authors.initials: R
authors.lastname: Osagie-Paech
authors.forename: K
authors.initials: K
authors.lastname: Richter
authors.forename: W
authors.initials: W
authors.lastname: Randerath
mesh_terms: D000465:Algorithms; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis* / Q000628:therapy*; D013813:Therapy, Computer-Assisted / Q000379:methods*; D016896:Treatment Outcome