Does premature luteinization or early surge of LH impair cycle outcome? Report of two successful outcomes.
OBJECTIVE
To report two successful antagonist IVF cycles; one ending up with pregnancy despite premature luteinization (case 1, aged 35 years), and the other with the retrieval of high quality oocytes despite premature ovulation (case 2, aged 39 years).


METHODS
Serum LH was 36 and 47 IU/L on cycle day 7 before antagonist administration, which was then brought to 6.94 and 3.92 IU/L by antagonist administration, and kept below these levels throughout the remaining stimulation in case 1 and 2 respectively. Serum progesterone was 1.42 and 5.5 ng/mL on the day of hCG respectively. Ten metaphase II (MII) oocytes were harvested wherein 3 grade A embryos were transferred in case 1, and seven good quality MII oocytes were retrieved wherein six embryos were cryopreserved in case 2.


CONCLUSIONS
More precise cut thresholds for both LH and progesterone are necessary for accurate prediction of the cycle outcomes.
Sönmezer
Murat
M
Department of Obstetrics and Gynecology, IVF Unit, Ankara University School of Medicine, Ankara University Center for Research on Human Reproduction (USAUM), Ankara, Turkey. msonmezer@gmail.com
Pelin Cil
Aylin
A
Atabekoğlu
Cem
C
Ozkavukçu
Sinan
S
Ozmen
Batuhan
B
D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D006727:Hormone Antagonists / Q000008:administration & dosage*; D006801:Humans; D007246:Infertility / Q000503:physiopathology / Q000628:therapy; D034461:Luteinization / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology; D010062:Ovulation Induction; D011247:Pregnancy; D013997:Time Factors; D016896:Treatment Outcome
D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; C062876:cetrorelix