Bypass specialists operate together.
New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (pol zeta) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.
Takata
Kei-ichi
K
Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
Wood
Richard D
RD
D000818:Animals; D020134:Catalytic Domain; D004247:DNA / Q000737:chemistry; D018736:DNA Adducts / Q000737:chemistry; D004249:DNA Damage; D017931:DNA Primers / Q000737:chemistry; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D019281:Dimerization; D006801:Humans; D008954:Models, Biological; D011743:Pyrimidines / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014466:Ultraviolet Rays
D018736:DNA Adducts; D017931:DNA Primers; D011743:Pyrimidines; D004247:DNA; D004259:DNA-Directed DNA Polymerase; C030986:pyrimidine