title: An elevated value of high mobility group box 1 is a potential marker for poor response to high-dose of intravenous immunoglobulin treatment in patients with Kawasaki syndrome.
abstract: We examined the serum values of high mobility group box 1 (HMGB1) in 36 patients with Kawasaki syndrome (KS) (29 responders and 7 poor-responders to initial intravenous immunoglobulin treatment). A mean value of HMGB1 of poor-responders was significantly elevated compared with those of responders (P = 0.0042). Among the 6 factors showing significant differences between responders and poor-responders including HMGB1 (admission illness day, white blood cell counts, C-reactive protein, aspartate aminotransferase, lactate dehydrogenase), values of HMGB1 showed the widest area under the receiver operating characteristic curve. In conclusion, an elevated HMGB1 value could be a potential marker for poor-responders.
authors.affiliation: Division of Pediatrics, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.
authors.forename: Taisuke
authors.initials: T
authors.lastname: Eguchi
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nomura
authors.forename: Teruto
authors.initials: T
authors.lastname: Hashiguchi
authors.forename: Kiminori
authors.initials: K
authors.lastname: Masuda
authors.forename: Michiko
authors.initials: M
authors.lastname: Arata
authors.forename: Daisuke
authors.initials: D
authors.lastname: Hazeki
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ueno
authors.forename: Junichiro
authors.initials: J
authors.lastname: Nishi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kawano
authors.forename: Ikuro
authors.initials: I
authors.lastname: Maruyama
mesh_terms: D015415:Biomarkers; D002675:Child, Preschool; D005260:Female; D024243:HMGB1 Protein / Q000097:blood*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D012372:ROC Curve; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D024243:HMGB1 Protein; D016756:Immunoglobulins, Intravenous