title: Utilization of dynamic CT perfusion in the study of intracranial meningiomas and their surrounding tissue.
abstract: OBJECTIVE
  To use CT perfusion (CTP) to assess levels of ischemia in brain areas around intracranial meningiomas.
  
  
  METHODS
  Fifteen patients with intracranial meningiomas were analysed preoperatively with CTP study. The cerebral blood flow (CBF), cerebral blood volume (CBV) and time to peak (TTP) were measured in the edema, peritumoral edema and in the normal areas of brain.
  
  
  RESULTS
  The peritumoral edema measured a mean CBF of 17.36 ml/min/100 ml (median=15.8) and the mean CBF value in the whole edema was 93.86 ml/min/100 ml (median=79.9). The mean CBV measured in the peritumoral edema was 2.7 (median=2.3) and the measured mean CBV of edema was 15 (median=13.2). In the region of the peritumoral edema, the mean CBF and CBV were lower than in the edema bed. Normal brain remote from the edema measured less CBF (mean=28.36 ml/min/100 ml, median=29.7) and CBV (mean=4.1, median=3.8) than the edema. Six patients were noted to have CBF of less than 15 ml/min/100 ml in the perilesional edema. The measured mean CBF and CBV in the normal area of brain were higher than in the peritumoral edema, while the TTP was greater in the perilesional edema (mean=11, median=10.4) when compared with areas of normal brain (mean=9.9, median=9.5) with statistically significant p values.
  
  
  CONCLUSIONS
  The values obtained elucidate the fact that perilesional edematous areas are ischemic. By subset analysis, it may be possible to identify those areas with recoverable tissue from non-recoverable tissue.
authors.affiliation: Department of Neurosciences, Kings College Hospital, London SE5 9RS, UK. ysergides@hotmail.com
authors.forename: Ioannis
authors.initials: I
authors.lastname: Sergides
authors.forename: Zakier
authors.initials: Z
authors.lastname: Hussain
authors.forename: Sunil
authors.initials: S
authors.lastname: Naik
authors.forename: Catriona
authors.initials: C
authors.lastname: Good
authors.forename: Ken
authors.initials: K
authors.lastname: Miles
authors.forename: Giles
authors.initials: G
authors.lastname: Critchley
mesh_terms: D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging; D001929:Brain Edema / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation / Q000502:physiology; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008579:Meningioma / Q000000981:diagnostic imaging*; D012984:Software; D014057:Tomography, X-Ray Computed