title: Immune status, psychosocial distress and reduced quality of life in infertile patients with endometriosis.
abstract: OBJECTIVE
  The aim of the study was to identify if (i) psychosocial factors differ in endometriosis; (ii) related psychosocial aspects alter immune markers of depression/sickness behaviour; and (iii) serum immune marker may be indicative for endometriosis.
  
  
  METHODS
  We enrolled 103 women in a case-control study. Psychosocial data were obtained, serum levels of interleukin (IL)-2, IL-4, IL-5, IL-6, IL-10, IL-12, IL-13, interferon (IFN)-gamma, TNF-alpha, IFN-alpha and soluble intercellular adhesion molecule-1 (sICAM-1) were analysed.
  
  
  RESULTS
  Among 69 eligible patients, endometriosis was diagnosed in 38 women. Patients with endometriosis reported reduced quality of life, increased stress perception/depressive symptoms; the Th1/Th2 ratio was in favour of Th1, accompanied by the increased levels of IFN-alpha. sICAM-1 levels were unaffected. No correlation could be confirmed between psychosocial and immune markers.
  
  
  CONCLUSIONS
  Women with endometriosis may benefit from strategies contributing to reduction of stress and development of coping mechanisms, thus helping to break the vicious circle of inflammation, sickness behaviour and depression.
authors.affiliation: Department of Obstetrics and Gynecology, DRK-Kliniken Westend, Berlin, Germany. f.siedentopf@drk-kliniken-westend.de
authors.forename: Friederike
authors.initials: F
authors.lastname: Siedentopf
authors.forename: Nadja
authors.initials: N
authors.lastname: Tariverdian
authors.forename: Mirjam
authors.initials: M
authors.lastname: Rücke
authors.forename: Heribert
authors.initials: H
authors.lastname: Kentenich
authors.forename: Petra C
authors.initials: PC
authors.lastname: Arck
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000276:immunology* / Q000378:metabolism; D016207:Cytokines / Q000097:blood*; D003863:Depression / Q000209:etiology* / Q000523:psychology; D004715:Endometriosis / Q000150:complications / Q000276:immunology* / Q000523:psychology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology* / Q000523:psychology*; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines