title: Acylated iridoids with cytotoxicity from Valeriana jatamansi.
abstract: Thirteen new acylated iridoids, jatamanvaltrates A-M (1-13), together with nine known valepotriates (14-22), were isolated from the whole plants of Valeriana jatamansi (syn. Valeriana wallichii). The structures of these new compounds were assigned by detailed interpretation of spectroscopic data. Jatamanvaltrates D (4) and H (9) are the first examples of naturally occurring valepotriates containing an o-hydroxybenzoyloxy moiety at C-10. All isolated compounds were tested for their cytotoxicity against lung adenocarcinoma (A549), metastatic prostate cancer (PC-3M), colon cancer (HCT-8), and hepatoma (Bel7402) cell lines.
authors.affiliation: Department of Phytochemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
authors.forename: Xian-Wen
authors.initials: XW
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Chen
authors.forename: Long-Hai
authors.initials: LH
authors.lastname: Lu
authors.forename: Zheng-Sheng
authors.initials: ZS
authors.lastname: Huang
authors.forename: Run-Hui
authors.initials: RH
authors.lastname: Liu
authors.forename: Xi-Ke
authors.initials: XK
authors.lastname: Xu
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014632:Valerian / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D039823:Iridoids