title: Acute motor response following a single IVIG treatment course in chronic inflammatory demyelinating polyneuropathy.
abstract: In chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), the acute motor response following withdrawal and reestablishment of intravenous immunoglobulin (IVIG) therapy was studied. In a prospectively designed case series 11 CIDP patients in IVIG maintenance therapy were assessed with isokinetic dynamometry, nerve conduction studies, and functional tests. After short-term withdrawal of IVIG, eight treatment-responsive patients had a 14.2% (8.6-20.0) loss of isokinetic strength of 12 muscle groups. Three patients remained stable without treatment and were excluded from further study. On days 5 and 10 after reinitiation of IVIG therapy isokinetic muscle strength increased by 5.5% (1.6-9.6) and 11.9% (7.5-16.5), respectively, but there was no further increase at day 15. Improvement of walking velocity and hand function coincided. The minimal F-wave latency shortened, whereas other electrophysiological parameters remained unchanged. In conclusion, isokinetic dynamometry is a sensitive and clinically relevant method for monitoring the acute response to IVIG treatment in CIDP.
authors.affiliation: Department of Neurology, Aarhus University Hospital, Noerrebrogade 44, 8000 Aarhus C, Denmark. Thomas.harbo@ki.au.dk
authors.forename: Thomas
authors.initials: T
authors.lastname: Harbo
authors.forename: Henning
authors.initials: H
authors.lastname: Andersen
authors.forename: Johannes
authors.initials: J
authors.lastname: Jakobsen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000009:adverse effects; D007551:Isotonic Contraction / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D053580:Muscle Strength / Q000187:drug effects* / Q000502:physiology; D053581:Muscle Strength Dynamometer; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D011446:Prospective Studies; D011788:Quality of Life; D011984:Sensory Receptor Cells / Q000502:physiology; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000503:physiopathology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors