Migration, maintenance and recall of memory T cells in peripheral tissues.
After the resolution of an immune response, antigen-specific memory T cells persist at many sites in the body. The antigen-specific memory T-cell pool includes memory T cells that preferentially reside in peripheral tissues, such as the skin, gut and lungs, where they provide a first line of defence against secondary pathogen infection. Determining how peripheral memory T cells are regulated is essential for our understanding of host-pathogen interactions and for vaccine development. In this Review, we discuss recent insights into the generation, control and recall of peripheral T-cell memory responses.
Woodland
David L
DL
Trudeau Institute, Saranac Lake, New York 12983, USA. dwoodland@trudeauinstitute.org
Kohlmeier
Jacob E
JE
D000818:Animals; D002465:Cell Movement; D003141:Communicable Diseases / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D006801:Humans; D007110:Immunity, Active; D007156:Immunologic Memory; D007422:Intestines / Q000276:immunology; D008168:Lung / Q000276:immunology; D012867:Skin / Q000276:immunology; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*; D014612:Vaccines / Q000276:immunology
D014612:Vaccines