An efficient synthesis of substituted 2-iminothiazolidin-4-one and thiadiazoloquinazolinone derivatives.
A convenient synthesis of functionalized 2-iminothiazolidin-4-ones and thiadiazoloquinazolinones has been achieved by the reaction of dialkyl acetylenedicarboxylates (DAAD) with 1-pheny-3-pyridin-2-yl-thiourea (1) and 3-amino-2-mercapto-3H-quinazolin-4-one (8), respectively. The starting materials for these processes were prepared from phenyl isothiocyanate, 2-aminopyridine for (1) and anthranilic acid, carbon disulfide, hydrazine for (8). Treatment of these compounds with DAAD resulted in the formation of an intermediate that readily underwent intramolecular cyclization to afford functionalized five membered heterocyclic rings was formed.
Ahmadi
Ali
A
Department of Chemistry, Shahid Bahonar University of Kerman, 76169 Kerman, Iran.
Saidi
Kazem
K
Khabazzadeh
Hojattollah
H
D000480:Alkynes / Q000737:chemistry; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D052999:Quinazolinones / Q000138:chemical synthesis* / Q000737:chemistry; D013830:Thiadiazoles / Q000737:chemistry; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry
D000480:Alkynes; D052999:Quinazolinones; D013830:Thiadiazoles; D053778:Thiazolidines; C022918:acetylenedicarboxylic acid dimethyl ester; D013890:Thiourea