title: A reduced SNARE model for membrane fusion.
abstract: Let's get together: A minimal model system was developed to mimic the SNARE-protein-mediated fusion of biological membranes (see picture). Fusion between two populations of liposomes is controlled by a pair of complementary lipidated oligopeptides that form noncovalent coiled-coil complexes and thereby force the membranes into close proximity to promote fusion. The model system displays the key characteristics of in vivo fusion events.
authors.affiliation: Leiden Institute of Chemistry, Leiden University, P.O. Box 9502, 2300 RA, Leiden, The Netherlands.
authors.forename: Hana
authors.initials: H
authors.lastname: Robson Marsden
authors.forename: Nina A
authors.initials: NA
authors.lastname: Elbers
authors.forename: Paul H H
authors.initials: PH
authors.lastname: Bomans
authors.forename: Nico A J M
authors.initials: NA
authors.lastname: Sommerdijk
authors.forename: Alexander
authors.initials: A
authors.lastname: Kros
mesh_terms: D000595:Amino Acid Sequence; D002942:Circular Dichroism; D036341:Intercellular Signaling Peptides and Proteins; D008051:Lipid Bilayers / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry; D008561:Membrane Fusion; D046529:Microscopy, Electron, Transmission; D008956:Models, Chemical; D010455:Peptides / Q000737:chemistry; D050600:SNARE Proteins / Q000737:chemistry*
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008051:Lipid Bilayers; D008081:Liposomes; D010455:Peptides; D050600:SNARE Proteins; C043948:lipid-associating peptides