title: Modified deep sclerectomy (D-lectomy MMC) for primary open-angle glaucoma: preliminary results.
abstract: OBJECTIVE
  To evaluate the outcome of modified deep sclerectomy [D-lectomy mitomycin C (MMC)] for medically refractory glaucoma patients.
  
  
  METHODS
  In a retrospective comparative study, the surgical outcome in 1 eye each of 31 patients who underwent D-lectomy MMC was compared with that of 91 eyes of 91 patients who underwent trabeculectomy with adjunctive MMC. These eyes had a diagnosis of primary open-angle glaucoma or pseudoexfoliation glaucoma, a record of high intraocular pressure (IOP) exceeding 25 mm Hg, and planned for surgical intervention. In the D-lectomy MMC cases, a slit incision at the trabecular meshwork and peripheral iridectomy were created. The "lake" and trabeculo-Descemet membrane ("window") were examined by ultrasound biomicroscope, gonioscopy, and time-domain optical coherence tomography.
  
  
  RESULTS
  Postsurgical IOP at 1, 3, 6, and 12 months after the D-lectomy MMC and trabeculectomy MMC were comparable (P=0.63-0.97). The filtering bleb was noted in 14 (45%) of the 31 D-lectomy MMC eyes at 3 months, and their survival was significantly less than trabeculectomy MMC subjects in which 81 of 91 eyes had the bleb at 3 months (P<0.0001). The lake was noted in 29 of 31 D-lectomy MMC eyes. The sealing of the once penetrated trabecular meshwork was complete at 3 months in 23 of 29 eyes by ultrasound biomicroscopic and/or gonioscopic examinations, whereas that was incomplete in 6 eyes.
  
  
  CONCLUSIONS
  Addition of a slit incision to the trabecular meshwork and peripheral iridectomy (D-lectomy MMC) improved postsurgical IOP of the deep sclerectomy to the level comparable with trabeculectomy MMC, with a less frequency of the bleb formation.
authors.affiliation: Sensho-kai Eye Institute, Uji, Kyoto, Japan. chihara-oph@umin.net
authors.forename: Etsuo
authors.initials: E
authors.lastname: Chihara
authors.forename: Kazushiro
authors.initials: K
authors.lastname: Okazaki
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Takuhei
authors.initials: T
authors.lastname: Shoji
authors.forename: Hatsuto
authors.initials: H
authors.lastname: Adachi
authors.forename: Ken
authors.initials: K
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D017889:Exfoliation Syndrome / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005902:Glaucoma, Open-Angle / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006068:Gonioscopy; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D033401:Microscopy, Acoustic; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D012189:Retrospective Studies; D012590:Sclera / Q000601:surgery*; D012599:Sclerostomy / Q000379:methods*; D041623:Tomography, Optical Coherence; D014130:Trabeculectomy / Q000379:methods; D016896:Treatment Outcome
chemical_list: D016685:Mitomycin