Intracerebral Hodgkin's lymphoma in a patient with chronic lymphocytic leukemia/small lymphocytic lymphoma: a case report and literature review.
Richter's syndrome is defined as the transformation of low grade lymphoma to more aggressive high grade malignant form, usually diffuse large B cell lymphoma. Primary or metastatic cerebral Hodgkin's lymphoma and Hodgkin's lymphoma variant of Richter transformation are extremely rare. We report a case of 65-year old man who developed isolated intracerebral Hodgkin's lymphoma almost 8 years after the diagnosis of chronic lymphocytic leukemia/small lymphocytic lymphoma, and we reviewed the related literature. The patient had resection of his CNS lesion, followed by radiation and chemotherapy. The patient eventually died with progressive disease.
Almhanna
Khaldoun
K
Department of Hematologic Oncology and Blood Disorders, Cleveland Clinic, Taussig Cancer Institute, Cleveland, Ohio 44195, USA. almhank@CCF.org
Wongchaowart
Nicholas
N
Sweetenham
John
J
D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D006689:Hodgkin Disease / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*