Genomic profiling of mesenchymal stem cells.
Mesenchymal stem/stromal cells (MSC) are an accessible source of precursor cells that can be expanded in vitro and used for tissue regeneration for different clinical applications. The advent of microarray technology has enabled the monitoring of individual and global gene expression patterns across multiple cell populations. Thus, genomic profiling has fundamentally changed our capacity to characterize MSCs, identify potential biomarkers and determined key molecules regulating biological processes involved in stem cell survival, growth and development. Numerous studies have now examined the genomic profiles of MSCs derived from different tissues that exhibit varying levels of differentiation and proliferation potentials. The knowledge gained from these studies will help improve our understanding of the cellular signalling pathways involved in MSC growth, survival and differentiation, and may aid in the development of strategies to improve the tissue regeneration potential of MSCs for different clinical indications. The present review summarizes studies characterizing the gene expression profile of MSCs.
Menicanin
Danijela
D
Mesenchymal Stem Cell Group, Bone and Cancer Laboratories, Division of Haematology, Institute of Medical and Veterinary Science/ Hanson Institute and CSCR, University of Adelaide, SA, Australia.
Bartold
P Mark
PM
Zannettino
Andrew C W
AC
Gronthos
Stan
S
D017667:Adipocytes / Q000166:cytology; D000818:Animals; D015415:Biomarkers; D001854:Bone Marrow Cells / Q000166:cytology*; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D020869:Gene Expression Profiling; D005821:Genetic Techniques; D023281:Genomics; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis; D017154:Stromal Cells / Q000166:cytology*
D015415:Biomarkers