Cisplatinum and docetaxel for ovarian cancer in pregnancy.
BACKGROUND
There is limited data on chemotherapy for advanced ovarian cancer during pregnancy. Most women received cisplatin-based chemotherapy. There are no published reports on the use of docetaxel for ovarian cancer in pregnancy.


METHODS
A 32-year-old pregnant lady underwent laparatomy at 18-week gestation for ruptured ovarian cyst. The pregnancy was the result of in vitro fertilization with intracytoplasmic sperm injection. Left salpingo-oophorectomy and omental biopsy were done. A diagnosis of stage IIIC, poorly differentiated papillary serous adenocarcinoma of the ovary was made. She was given four cycles of cisplatinum and docetaxel followed by cesarean hysterectomy, right salpingo-oophorectomy, and cytoreductive surgery. The mother is well and has completed six cycle of chemotherapy.


CONCLUSIONS
This is the first report on the use of docetaxel during pregnancy for ovarian cancer.
Rouzi
Abdulrahim A
AA
Department of Obstetrics and Gynecology, King Abdulaziz University, PO Box 80215, Jeddah 21589, Saudi Arabia. aarouzi@gmail.com
Sahly
Nora N
NN
Sahly
Naif F
NF
Alahwal
Mahmoud S
MS
D000231:Adenocarcinoma, Papillary / Q000097:blood / Q000188:drug therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018394:CA-125 Antigen / Q000097:blood; D002585:Cesarean Section; D002945:Cisplatin / Q000008:administration & dosage; D000077143:Docetaxel; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood / Q000188:drug therapy* / Q000601:surgery; D043823:Taxoids / Q000008:administration & dosage
D018394:CA-125 Antigen; D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin