title: CD44 targeting reduces tumour growth and prevents post-chemotherapy relapse of human breast cancers xenografts.
abstract: CD44 is a marker of tumour-initiating cells and is upregulated in invasive breast carcinoma; however, its role in the cancer progression is unknown. Here, we show that antibody-mediated CD44-targeting in human breast cancer xenografts (HBCx) significantly reduces tumour growth and that this effect is associated to induction of growth-inhibiting factors. Moreover, treatment with this antibody prevents tumour relapse after chemotherapy-induced remission in a basal-like HBCx.
authors.affiliation: Translational Research Department, Institut Curie, 75010 Paris, France. Elisabetta.Marangoni@curie.fr
authors.forename: E
authors.initials: E
authors.lastname: Marangoni
authors.forename: N
authors.initials: N
authors.lastname: Lecomte
authors.forename: L
authors.initials: L
authors.lastname: Durand
authors.forename: G
authors.initials: G
authors.lastname: de Pinieux
authors.forename: D
authors.initials: D
authors.lastname: Decaudin
authors.forename: C
authors.initials: C
authors.lastname: Chomienne
authors.forename: F
authors.initials: F
authors.lastname: Smadja-Joffe
authors.forename: M-F
authors.initials: MF
authors.lastname: Poupon
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis / Q000276:immunology / Q000502:physiology*; D008325:Mammary Neoplasms, Experimental / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D023041:Xenograft Model Antitumor Assays
chemical_list: D000911:Antibodies, Monoclonal; C476399:Cd44 protein, mouse; D018960:Hyaluronan Receptors