title: Stereotactic interstitial radiosurgery for intracranial Rosai-Dorfman disease. A novel therapeutic approach.
abstract: BACKGROUND
  Rosai-Dorfman disease is an idiopathic, histoproliferative disorder characterized by massive painless lymphadenopathy. The favorable treatment of Rosai-Dorfman disease affecting the central nervous system is surgical resection. Histological and immunohistochemical confirmation is essential for a definitive diagnosis.
  
  
  METHODS
  The authors report on a 10-year-old patient with Rosai-Dorfman disease of the central nervous system who presented with increased intracranial pressure. She was treated by stereotactic interstitial irradiation using iodine-125 seeds (interstitial radiosurgery).
  
  
  RESULTS
  Stereotactic surgery was performed without complications. The patient recovered well to a normal neurologic status. MR images showed a complete remission 49 months after treatment.
  
  
  CONCLUSIONS
  The presented case demonstrates the high efficacy and safety of interstitial irradiation for intracranial Rosai-Dorfman disease. Hence, interstitial radiosurgery could be an appropriate therapeutic option for high-risk resectable intracranial Rosai-Dorfman disease.
authors.affiliation: Department of Stereotactic and Functional Neurosurgery, University of Cologne, Köln, Germany.
authors.forename: Faycal
authors.initials: F
authors.lastname: El Majdoub
authors.forename: Anna
authors.initials: A
authors.lastname: Brunn
authors.forename: Frank
authors.initials: F
authors.lastname: Berthold
authors.forename: Volker
authors.initials: V
authors.lastname: Sturm
authors.forename: Mohammad
authors.initials: M
authors.lastname: Maarouf
mesh_terms: D001927:Brain Diseases / Q000175:diagnosis* / Q000532:radiotherapy*; D002648:Child; D005260:Female; D015618:Histiocytosis, Sinus / Q000175:diagnosis* / Q000532:radiotherapy*; D006801:Humans; D016634:Radiosurgery / Q000379:methods*; D016896:Treatment Outcome