Subcorneal pustulosis with combined lack of IgG/IgM and monoclonal gammopathy type IgA/Kappa.
Subcorneal pustulosis (Sneddon-Wilkinson disease) is a rare inflammatory neutrophilic dermatosis. While subcorneal pustulosis is often associated with an IgA gammopathy, the combined lack of IgG/IgM seen in our case is rare. An 83-year-old man with combined lack of IgG/IgM and monoclonal gammopathy type IgA/Kappa presented with subcorneal pustules. Intravenous immunoglobulin therapy led to complete regression and might be another therapeutic option.
Rasch
Astrid
A
Eduard Arning Clinic for Dermatology and Allergy, Asklepios Clinic St. Georg, Hamburg, Germany. raschastrid@hotmail.com
Schimmer
Melanie
M
Sander
Christian A
CA
D000369:Aged, 80 and over; D006801:Humans; D017099:IgG Deficiency / Q000150:complications* / Q000188:drug therapy*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007155:Immunologic Factors / Q000008:administration & dosage; D008297:Male; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000188:drug therapy*; D016896:Treatment Outcome
D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors