Transcription-factor-mediated epigenetic control of cell fate and lineage commitment.
Epigenetic control is required to maintain competency for the activation and suppression of genes during cell division. The association between regulatory proteins and target gene loci during mitosis is a parameter of the epigenetic control that sustains the transcriptional regulatory machinery that perpetuates gene-expression signatures in progeny cells. The mitotic retention of phenotypic regulatory factors with cell cycle, cell fate, and tissue-specific genes supports the coordinated control that governs the proliferation and differentiation of cell fate and lineage commitment.
Stein
Gary S
GS
Department of Cell Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655-0002, USA. gary.stein@umassmed.edu
Zaidi
Sayyed K
SK
Stein
Janet L
JL
Lian
Jane B
JB
van Wijnen
Andre J
AJ
Montecino
Martin
M
Young
Daniel W
DW
Javed
Amjad
A
Pratap
Jitesh
J
Choi
Je-Yong
JY
Ali
Syed A
SA
Pande
Sandhya
S
Hassan
Mohammad Q
MQ
D000818:Animals; D019070:Cell Lineage / Q000235:genetics*; D002467:Cell Nucleus / Q000235:genetics; D049109:Cell Proliferation; D044127:Epigenesis, Genetic; D006801:Humans; D008938:Mitosis; D014157:Transcription Factors / Q000378:metabolism*
D014157:Transcription Factors