Entry of herpesviruses into cells: more than one way to pull the trigger.
Interaction of viral protein gp42 with its receptor is the trigger for the entry of Epstein-Barr virus into B cells. The structure of gp42 reported by Kirschner etal. (2009) in this issue of Structure suggests a likely triggering mechanism substantially different from that of a related herpesvirus.
Heldwein
Ekaterina E
EE
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA. katya.heldwein@tufts.edu
D000818:Animals; D001402:B-Lymphocytes / Q000821:virology*; D006564:Herpesviridae / Q000502:physiology*; D004854:Herpesvirus 4, Human / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D011485:Protein Binding; D053586:Virus Internalization
D008562:Membrane Glycoproteins