title: Primary pituitary lymphoma: a histological, immunohistochemical, and ultrastructural study with literature review.
abstract: We report the case of a 62-year-old man with headache and left sixth cranial nerve palsy. A computerized tomography scan revealed an osteolytic process involving the sella turcica and clivus. A partial tumor resection was achieved via an endoscopic transsphenoidal approach. Morphologic investigation revealed a diffuse large B cell lymphoma involving pituitary parenchyma. No systemic disease was found upon staging. Primary pituitary lymphoma is extremely rare. An accurate histologic diagnosis is key to successful treatment and a favorable prognosis. The literature is reviewed.
authors.affiliation: Department of Laboratory Medicine, St. Michael's Hospital, Toronto, Ontario, M5B 1W8, Canada. olga_m99@hotmail.com
authors.forename: Olga
authors.initials: O
authors.lastname: Moshkin
authors.forename: Paul
authors.initials: P
authors.lastname: Muller
authors.forename: Bernd W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: Jonathan
authors.initials: J
authors.lastname: Juco
authors.forename: Eva
authors.initials: E
authors.lastname: Horvath
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Patterson
authors.forename: Suzzane
authors.initials: S
authors.lastname: Kamel-Reid
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000378:metabolism / Q000648:ultrastructure*; D008297:Male; D046529:Microscopy, Electron, Transmission; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000648:ultrastructure*; D014057:Tomography, X-Ray Computed