title: Treatment outcomes after radiotherapy alone for patients with early-stage nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To analyze the treatment outcomes of patients with early-stage nasopharyngeal carcinoma after radiotherapy (RT) alone and discuss the effects of different T and N stages on the prognosis.
  
  
  METHODS
  The clinical data from 362 early-stage (T1-T2N0-N1M0, 1992 Fuzhou, China staging system) nasopharyngeal carcinoma patients who had undergone RT alone between January 1999 and December 2001 and were hospitalized in the Cancer Center of Sun Yat-Sen University were collected and reviewed.
  
  
  RESULTS
  The median follow-up was 70 months. The 5-year overall survival rate for the whole group was 85%. The 5-year overall survival rate of those with T1N0, T2N0, and T1N1 was 96.6%, 91.3%, and 85.8%, respectively, with no statistically significant difference detected among the three groups (p > .05). However, the 5-year overall survival rate of 73.1% for those with Stage T2N1 was significantly different from that of the former three groups. The 5-year local recurrence-free survival and 5-year regional recurrence-free survival rates among the four groups was not significantly different (p < .05). The 5-year distant metastasis-free survival rate of those with Stage T1N0, T2N0, and T1N1 was 94.9%, 97.5%, and 95.6%, respectively, without any significant differences (p > .05); however, the 81.2% rate for those with Stage T2N1 was significantly different (p < .05).
  
  
  CONCLUSIONS
  RT alone for Stage T1N0, T2N0, and T1N1 yielded satisfactory results. The outcome for those with T2N1 was obviously poorer than that for the other three groups. The main reason for treatment failure in this group was distant metastasis. Patients who have a high risk of distant metastasis in the T2N1 group may need combined treatment instead of RT alone.
authors.affiliation: Department of Radiation Oncology, State Key Laboratory of Oncology in Southern China, Guangzhou, China.
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Xiao
authors.forename: Fei
authors.initials: F
authors.lastname: Han
authors.forename: Tai-Xiang
authors.initials: TX
authors.lastname: Lu
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Chen
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Chong
authors.initials: C
authors.lastname: Zhao
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult