title: Eye tracking during a visual paired comparison task as a predictor of early dementia.
abstract: The authors present findings from a behavioral task (visual paired comparison) using infrared eye-tracking that could potentially be useful in predicting the onset of Alzheimer's disease. Delay intervals of 2 seconds and 2 minutes were used between the initial viewing of a picture and when the picture was displayed alongside a novel picture. Eye-tracking revealed that at the 2-second delay, 6 patients with mild cognitive impairment, 15 matched control participants (normal control), and 4 neurological control participants with Parkinson's disease performed comparably, viewing the novel picture greater than 71% of the time. When the delay increased to 2 minutes, patients with mild cognitive impairment viewed the novel picture only 53% of the time (P < .05), while control participants and participants with Parkinson's disease remained above 70%. These findings demonstrate the usefulness of this task for assessing normal as well as impaired memory function.
authors.affiliation: Yerkes National Primate Research Center, Emory University, Emory Alzheimer's Disease Research Center, Atlanta, Georgia, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Crutcher
authors.forename: Rose
authors.initials: R
authors.lastname: Calhoun-Haney
authors.forename: Cecelia M
authors.initials: CM
authors.lastname: Manzanares
authors.forename: James J
authors.initials: JJ
authors.lastname: Lah
authors.forename: Allan I
authors.initials: AI
authors.lastname: Levey
authors.forename: Stuart M
authors.initials: SM
authors.lastname: Zola
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003704:Dementia / Q000175:diagnosis* / Q000503:physiopathology; D053483:Eye Movement Measurements; D005133:Eye Movements / Q000502:physiology*; D006801:Humans; D010300:Parkinson Disease / Q000503:physiopathology; D010775:Photic Stimulation; D013997:Time Factors