[Genetic polymorphism and risk of arterial thrombosis in patients with atrial fibrillation].
This study revealed the importance of 6 genetic determinants (accounting for predisposition to thrombophilia) as risk factors of thromboembolic stroke in patients with atrial fibrillation (AF). The occurrence of A-allele of FGB gene of patients with complicated form of AF was shown to be significantly higher compared with controls. Carriage of FGB-455A, grade II mitral regurgitation, and AF longer than 48 hours are assumed to be independent predictors of thromboembolic stroke.
Serdechnaia
E V
EV
Tatarskiĭ
B A
BA
Kazakevich
E V
EV
D001281:Atrial Fibrillation / Q000150:complications* / Q000235:genetics; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D003328:Coronary Thrombosis / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005260:Female; D005340:Fibrinogen / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012426:Russia / Q000453:epidemiology
D005340:Fibrinogen; D004247:DNA