Search for MDR modulators: design, syntheses and evaluations of N-substituted acridones for interactions with p-glycoprotein and Mg2+.
By combining the structural features of acridone based anti-cancer drugs (like amsacrine) and MDR modulator propafenone, acridones with hydroxyl amine chain at N-10 have been designed and synthesized. These molecules exhibit appreciable interactions with p-gp and Mg(2+) indicating their suitability to modulate p-gp mediated multi drug resistance.
Singh
Palwinder
P
Department of Chemistry, Guru Nanak Dev University, Amritsar 143 005, India. palwinder_singh_2000@yahoo.com
Kaur
Jatinder
J
Kaur
Prabhjit
P
Kaur
Satwinderjeet
S
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry*; D054831:Acridones / Q000138:chemical synthesis* / Q000737:chemistry; D015195:Drug Design; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D008274:Magnesium / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D016339:Spectrometry, Mass, Fast Atom Bombardment
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D054831:Acridones; D008274:Magnesium