Regulation of imprinted expression by macro non-coding RNAs.
In mammals, imprinted genes are clustered and at least one gene in each imprinted cluster is a long i.e., macro non-coding (nc) RNA. Most genes in a cluster show concordant parental-specific expression but the ncRNA is the odd one out, and is expressed from the opposite parental chromosome. While reciprocal expression between imprinted macro non-coding RNAs and flanking mRNA genes is indicative of a functional role, only two of three tested macro ncRNAs have been shown to induce imprinted gene expression. The two known functional imprinted macro non-coding RNAs are both RNAPII transcripts with unusual transcriptional properties that may be functionally relevant and their analysis may shed light on the function of non-coding RNAs that have been shown to comprise the majority of the mammalian transcriptome.
Latos
Paulina A
PA
CeMM-Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna Biocenter, Vienna, Austria.
Barlow
Denise P
DP
D000818:Animals; D004622:Embryo, Mammalian / Q000502:physiology; D044127:Epigenesis, Genetic; D005260:Female; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D005810:Multigene Family; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D022661:RNA, Untranslated / Q000502:physiology*
D022661:RNA, Untranslated