The value of CD23 expression as an additional marker in distinguishing mediastinal (thymic) large B-cell lymphoma from Hodgkin lymphoma.
Mediastinal diffuse large B-cell lymphoma (Med-DLBCL) is a subtype of DLBCL that has morphologic and clinical similarities and phenotypic overlaps with classical Hodgkin lymphoma (CHL) involving the mediastinum. CD23 is a marker that has been previously reported in Med-DLBCI and is proposed in the differential diagnosis of M-DLBCL and CHL. A panel of immunostains, including CD45, CD20, CD3, CD30, CD15, CD21, and CD23 as well as Eber was performed on Med-DLBCL and 20CHL. 23/27 Med-DLBCL (85%) were positive for CD23 (membranous) CD30 was negative in 6 and positive in 21 cases. 18 CHL cases were negative for CD23 and only 2 showed rare scattered Reed-Sternberg cells with weak cytoplasmic CD23 staining. CD23 showed a sensitivity of 85% and positive predictive value of 92%. In conclusion CD23 is a useful marker in distinguishing Med-DLBCL and CHL in mediastinal biopsies and may be helpful as an adjunct to histomorphology and other markers in the diagnosis and appropriate clinical management of these lesions.
Salama
Mohamed E
ME
Department of Pathology, University of Utah Health Sciences Center, Salt Lake City, Utah 84108, USA. mohamed.salama@path.utah.edu
Rajan Mariappan
M
M
Inamdar
Kedar
K
Tripp
Sheryl R
SR
Perkins
Sherrie L
SL
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000378:metabolism; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000378:metabolism; D008297:Male; D008479:Mediastinal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged; D011237:Predictive Value of Tests; D017455:Receptors, IgE / Q000378:metabolism*; D016539:Reed-Sternberg Cells / Q000473:pathology; D012189:Retrospective Studies; D013953:Thymus Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D055815:Young Adult
D014408:Biomarkers, Tumor; D017455:Receptors, IgE