title: [Two cases of interstitial lung diseases in patients treated with oxaliplatin, 5-fluorouracil and Leucovorin (FOLFOX)].
abstract: Oxaliplatin in combination with 5-fluorouracil (5-FU) and Leucovorin (FOLFOX) currently represents a valid approach for treating advanced colorectal cancer. In Japan, it is generally performed. Gastrointestinal, hematological and neurosensory toxicities are the most common. However, information concerning the pulmonary toxicity of this regimen is very limited. We report here two cases of interstitial lung disease occurring in association with the use of this combination chemotherapy. Reports of interstitial lung disease due to FOLFOX are infrequent, but could lead to severe complications. It is important to perform an X-ray examination regularly and detect symptoms early.
authors.affiliation: Dept. of Clinical Oncology, Iwate Prefectural Central Hospital.
authors.forename: Hisatsugu
authors.initials: H
authors.lastname: Ohori
authors.forename: Masanobu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Ogasawara
authors.forename: Michihiro
authors.initials: M
authors.lastname: Suzuki
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Miyate
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kato
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D008297:Male; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000900:Anti-Bacterial Agents; D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil