title: The effects of sodium pump inhibitors on sensory ganglion neurite growth.
abstract: The effects of sodium pump inhibitors of the cardiac glycoside family (strophanthin K and digoxin) on neurite growth in the sensory ganglia of chick embryos (10-12 days) were studied in organotypic tissue cultures. These experiments produced the first evidence that these medicinal agents have marked neurite-suppressing actions. Their effects on sensory ganglion neurite growth were dose-dependent. At 1.10(-6) M, strophanthin K and digoxin completely blocked sensory ganglion neurite growth. Addition of study compounds to the medium at a concentration of 1.10(-7) M decreased the area index of the experimental explants to a level significantly below that of the controls, by a mean of 45%. These strophanthin K and digoxin concentrations were comparable with those at which endogenous digitalis-like factors are present in the systemic circulation. These results provide evidence that cardiac glycosides can produce the directed regulation of nervous tissue growth by affecting the signal transducer Na+, K+-ATPase.
authors.affiliation: I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, 6 Makarov Bank, 199034, St. Petersburg, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Penniyainen
authors.forename: E V
authors.initials: EV
authors.lastname: Lopatina
authors.forename: V A
authors.initials: VA
authors.lastname: Tsyrlin
authors.forename: B V
authors.initials: BV
authors.lastname: Krylov
mesh_terms: D000818:Animals; D002642:Chick Embryo; D004077:Digoxin / Q000494:pharmacology*; D017950:Ganglia, Sensory / Q000187:drug effects* / Q000196:embryology / Q000502:physiology; D016501:Neurites / Q000187:drug effects* / Q000502:physiology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*; D013328:Strophanthins / Q000494:pharmacology*
chemical_list: D013328:Strophanthins; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase; C029082:strophanthin K