title: Characterization of white matter degeneration in elderly subjects by magnetic resonance diffusion and FLAIR imaging correlation.
abstract: Fluid attenuated inversion recovery (FLAIR) and diffusion tensor imaging (DTI) techniques have been widely used to evaluate white matter (WM) alterations associated with aging, dementia and cerebral vascular disease. The relationship between FLAIR detected WM lesions (WML) and DTI detected WM integrity changes, however, remains unclear. To investigate this association, voxelwise correlations between 4 Tesla DTI and FLAIR images from elderly subjects were performed by relating WML volume and intensity in FLAIR to fractional anisotropy (FA) and mean diffusivity (MD) in DTI. Significant DTI-FLAIR correlations were found in regions overlapping with the WML of moderate intensities in FLAIR. No significant correlations were detected in periventricular regions where the FLAIR intensities are particularly high. The findings are consistent with a transitional model for WM degeneration from normal WM to cerebrospinal fluid (CSF). The results show that the correlation between DTI and FLAIR disappears when the FLAIR intensity of WML reaches its maximum at a certain lesion severity, and that the correlations may remerge with reversed signs when the lesion severity is further increased. These results suggest that the different stages of WM degeneration in elderly subjects can be better characterized by regional DTI-FLAIR correlations than single modality alone.
authors.affiliation: University of California San Francisco, VA Medical Center, Department of Radiology, Center of Imaging for Neurodegenerative Diseases, 4150 Clement Street, 114M, San Francisco, CA 94121, USA. Wang.Zhan@ucsf.edu
authors.forename: Wang
authors.initials: W
authors.lastname: Zhan
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Susanne G
authors.initials: SG
authors.lastname: Mueller
authors.forename: Peter
authors.initials: P
authors.lastname: Lorenzen
authors.forename: Stathis
authors.initials: S
authors.lastname: Hadjidemetriou
authors.forename: Norbert
authors.initials: N
authors.lastname: Schuff
authors.forename: Michael W
authors.initials: MW
authors.lastname: Weiner
mesh_terms: D000368:Aged; D016880:Anisotropy; D001921:Brain / Q000473:pathology*; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009186:Myelin Sheath / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000473:pathology*; D009929:Organ Size