Resistin, adiponectin, and risk of heart failure the Framingham offspring study.
OBJECTIVE
We tested the association of the adipokines resistin and adiponectin with incident heart failure.


BACKGROUND
Abnormal concentrations of adipokines may partially explain the association between obesity and heart failure.


METHODS
We related circulating adipokine concentrations to the incidence of heart failure in 2,739 participants in the Framingham Offspring Study.


RESULTS
During 6 years of follow-up, 58 participants developed new-onset heart failure. In proportional hazards models (adjusting for age, sex, blood pressure, antihypertensive treatment, diabetes, smoking, total/high-density lipoprotein cholesterol ratio, prevalent coronary heart disease, valvular heart disease, left ventricular hypertrophy, and estimated glomerular filtration rate) using the lowest third of the resistin distribution as the referent, the hazard ratios for heart failure in the middle and top thirds were 2.89 (95% confidence interval [CI]: 1.05 to 7.92) and 4.01 (95% CI: 1.52 to 10.57), respectively (p = 0.004 for trend). Additional adjustment for body mass index, insulin resistance (measured with the homeostasis model), C-reactive protein, and B-type natriuretic peptide did not substantively weaken this association (multivariable hazard ratios [HRs]: 2.62 and 3.74, p = 0.007). In the maximally adjusted model, each SD increment in resistin (7.45 ng/ml) was associated with a 26% increase in heart failure risk (95% CI: 1% to 60%). Concentrations of adiponectin were not associated with heart failure (multivariable HRs: 0.87 and 0.97, p = 0.9).


CONCLUSIONS
Increased circulating concentrations of resistin were associated with incident heart failure, even after accounting for prevalent coronary heart disease, obesity, and measures of insulin resistance and inflammation. The findings suggest a role for resistin in human disease and a novel pathway to heart failure.
Frankel
David S
DS
Department of Medicine, Massachusetts General Hospital, Boston, 02114, USA.
Vasan
Ramachandran S
RS
D'Agostino
Ralph B
RB
Benjamin
Emelia J
EJ
Levy
Daniel
D
Wang
Thomas J
TJ
Meigs
James B
JB
D052242:Adiponectin / Q000097:blood*; D032721:Adult Children; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016001:Confidence Intervals; D017079:Exercise Tolerance; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008404:Massachusetts / Q000453:epidemiology; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D011237:Predictive Value of Tests; D011446:Prospective Studies; D052243:Resistin / Q000097:blood*; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D052242:Adiponectin; D015415:Biomarkers; D052243:Resistin; D020097:Natriuretic Peptide, Brain; D002097:C-Reactive Protein