title: Synthesis, characterization, and bioconjugation of fluorescent gold nanoclusters toward biological labeling applications.
abstract: Synthesis of ultrasmall water-soluble fluorescent gold nanoclusters is reported. The clusters have a decent quantum yield, high colloidal stability, and can be readily conjugated with biological molecules. Specific staining of cells and nonspecific uptake by living cells is demonstrated.
authors.affiliation: Department of Biomedical Engineering, Chung Yuan Christian University, Chung-Li 32023, Taiwan, ROC.
authors.forename: Cheng-An J
authors.initials: CA
authors.lastname: Lin
authors.forename: Ting-Ya
authors.initials: TY
authors.lastname: Yang
authors.forename: Chih-Hsien
authors.initials: CH
authors.lastname: Lee
authors.forename: Sherry H
authors.initials: SH
authors.lastname: Huang
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Sperling
authors.forename: Marco
authors.initials: M
authors.lastname: Zanella
authors.forename: Jimmy K
authors.initials: JK
authors.lastname: Li
authors.forename: Ji-Lin
authors.initials: JL
authors.lastname: Shen
authors.forename: Hsueh-Hsiao
authors.initials: HH
authors.lastname: Wang
authors.forename: Hung-I
authors.initials: HI
authors.lastname: Yeh
authors.forename: Wolfgang J
authors.initials: WJ
authors.lastname: Parak
authors.forename: Walter H
authors.initials: WH
authors.lastname: Chang
mesh_terms: D000818:Animals; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival; D002850:Chromatography, Gel; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013194:Staining and Labeling / Q000379:methods*; D013379:Substrate Specificity
chemical_list: D005456:Fluorescent Dyes; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; D006046:Gold