title: [Clinical analysis and laboratory findings in a patient with acquired hemophilia A].
abstract: In order to analyze the clinical features and laboratory findings in patients with acquired hemophilia A, one case of acquired hemophilia A was studied, the medical history, clinical features, ultrasonography and laboratory examination including activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and FVIII:C, FIX:C, FXI:C, FXII:C ratio, as well as medical treatment were analyzed. The results showed 99.3 sec of APTT, 13 sec of PT, and 13.5 sec of TT, 2% of FVIII:C, 7% of FIX:C, 9% of FXI:C and 21% of FXII:C. The prolongation of APTT could not be completely corrected by mixing the patient plasma with an equal volume of normal fresh plasma; the APTT increased with prolongation of incubation time, when patient plasma was mixed with an equal volume of normal fresh plasma and incubated at 37 degrees C. The plasma FVIII:C, FIX:C, FXI:C and FXII:C levels in patient were 6%, 75%, 95% and 123% respectively, when patient's plasma was diluted by tenfold and mixed with an equal volume of non-diluted normal plasma. FVIII inhibitor in the patient's serum was at a level >32.0 Bethesda units/ml after acquired hemophilia was diagnosed, the patient was admitted to hospital and given orally prednisone and azathioprine therapy. One month later, clinical status of the patient were improved with 33.3 seconds of APTT, 128% of FVIII level and elimination of FVIII inhibitor. In conclusion, inquiring case history, analyzing imaging results, detecting level of APTT, performing dilution test and assaying titer of FVIII inhibitor can reduce misdiagnosis and wrong therapy for patients with acquired hemophilia A. The FVIII inhibitor can be eliminated and function of clotting can be recovered by using immunosuppressive therapy.
authors.affiliation: Department of Hematology, Wenzhou Third People Hospital, Wenzhou 325000, China. xiebs308@126.com
authors.forename: Bing-Shou
authors.initials: BS
authors.lastname: Xie
authors.forename: Wen-Quan
authors.initials: WQ
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Huang
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Ye
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Hu
mesh_terms: D005169:Factor VIII / Q000032:analysis* / Q000037:antagonists & inhibitors; D005260:Female; D006467:Hemophilia A / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008875:Middle Aged
chemical_list: D005169:Factor VIII