Antibacterial activity of ultrashort cationic lipo-beta-peptides.
Previously reported D,L-lipo-alpha-peptides and their lipo-beta-peptide counterparts (C16-KGGK, C16-KAAK, C16-KKKK, and C12-KLLK) were studied, and the lipo-beta-peptides were found to retain antimicrobial activity. Likewise, no significant changes in antimicrobial activity were found upon activity comparisons with D,L-amino acid-based lipopeptides or any L-amino acid lipopeptides. As a defined amphipathic structure is unlikely to form with such short molecules and as similar activities were obtained from all lipopeptides, we suspect that the action of membrane permeation is retained.
Serrano
Griselda N
GN
Department of Chemistry, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada.
Zhanel
George G
GG
Schweizer
Frank
F
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002463:Cell Membrane Permeability; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects*; D006095:Gram-Positive Cocci / Q000145:classification / Q000187:drug effects*; D006801:Humans; D055666:Lipopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D055666:Lipopeptides