title: Multidrug resistance mediated by MRP1 gene overexpression in breast cancer patients.
abstract: Multidrug resistance (MDR) is a serious handicap towards the effective treatment of breast cancer patients. One of the most prevalent MDR mechanisms is through the overexpression of genes coding the proteins called Multidrug Resistance-associated Proteins (MRPs). The aim of this study was to investigate the expression of MRP1 in tumor tissues from breast cancer patients. In this study, a semi-quantitative RT-PCR approach was utilized. Our results suggest that MRP1 overexpression can mediate MDR in patients. Pre-evaluation of the level of such MDR mediators before chemotherapy can increase the efficacy of the treatment.
authors.affiliation: Department of Biology, Middle East Technical University, Ankara, Turkey.
authors.forename: Ogan Demir
authors.initials: OD
authors.lastname: Abaan
authors.forename: Pelin Kaya
authors.initials: PK
authors.lastname: Mutlu
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Baran
authors.forename: Can
authors.initials: C
authors.lastname: Atalay
authors.forename: Ufuk
authors.initials: U
authors.lastname: Gunduz
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D045744:Cell Line, Tumor; D003720:Densitometry; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D006801:Humans; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics / Q000502:physiology*; D001613:beta 2-Microglobulin / Q000235:genetics
chemical_list: D027425:ATP-Binding Cassette, Sub-Family C Proteins; D001613:beta 2-Microglobulin; C421109:multidrug resistance-associated protein 1