Stress and addiction: glucocorticoid receptor in dopaminoceptive neurons facilitates cocaine seeking.
The glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons expressing dopamine receptor 1a, but not in dopamine-releasing neurons, markedly decreased the motivation of mice to self-administer cocaine, dopamine cell firing and the control exerted by dopaminoceptive neurons on dopamine cell firing activity. In contrast, anxiety was unaffected, indicating that glucocorticoid receptors modify a number of behavioral disorders through different neuronal populations.
Ambroggi
Frédéric
F
INSERM U862, NeuroCenter Magendie, Pathophysiology of Addiction, 147 Rue Léo Saignat, 33077 Bordeaux Cedex, France.
Turiault
Marc
M
Milet
Aude
A
Deroche-Gamonet
Véronique
V
Parnaudeau
Sébastien
S
Balado
Eric
E
Barik
Jacques
J
van der Veen
Rixt
R
Maroteaux
Grégoire
G
Lemberger
Thomas
T
Schütz
Günther
G
Lazar
Monique
M
Marinelli
Michela
M
Piazza
Pier Vincenzo
PV
Tronche
François
F
D000818:Animals; D016739:Behavior, Addictive / Q000235:genetics / Q000378:metabolism* / Q000523:psychology; D003042:Cocaine / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D019970:Cocaine-Related Disorders / Q000235:genetics / Q000378:metabolism / Q000523:psychology; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D017447:Receptors, Dopamine D1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D012646:Self Administration; D013315:Stress, Psychological / Q000235:genetics / Q000378:metabolism* / Q000523:psychology
C497713:NR3C1 protein, human; D017447:Receptors, Dopamine D1; D011965:Receptors, Glucocorticoid; D003042:Cocaine; D004298:Dopamine