title: Frontolimbic function and cortisol reactivity in response to emotional stimuli.
abstract: Frontolimbic structures involved in fear conditioning have also been associated with hypothalamic-pituitary-adrenal (HPA)-axis modulation, including amygdaloid, hippocampal, and ventromedial prefrontal cortex regions. Although HPA-axis function and endocrine changes have been investigated in the context of stress provocation, much research has not been conducted using functional neuroimaging in the study of the HPA axis and frontolimbic function in response to emotional stimuli. Using functional magnetic resonance imaging, the association of blood-oxygen-level dependent signal with salivary cortisol in response to an emotional visual scene paradigm was investigated, with prescan and postscan salivary cortisol analyzed as a covariate of interest during specific conditions. Cortisol reactivity to the paradigm was positively associated with amygdalar and hippocampal activity and negatively associated with ventromedial prefrontal cortex activity in conditions involving emotional imagery.
authors.affiliation: Functional Neuroimaging Laboratory, Department of Psychiatry, PO Box 140, Weill Medical College of Cornell University, 1300 York Avenue, NY 10021, USA. jcr2003@med.cornell.edu
authors.forename: James C
authors.initials: JC
authors.lastname: Root
authors.forename: Oliver
authors.initials: O
authors.lastname: Tuescher
authors.forename: Amy
authors.initials: A
authors.lastname: Cunningham-Bussel
authors.forename: Hong
authors.initials: H
authors.lastname: Pan
authors.forename: Jane
authors.initials: J
authors.lastname: Epstein
authors.forename: Margaret
authors.initials: M
authors.lastname: Altemus
authors.forename: Marylene
authors.initials: M
authors.lastname: Cloitre
authors.forename: Martin
authors.initials: M
authors.lastname: Goldstein
authors.forename: Michael
authors.initials: M
authors.lastname: Silverman
authors.forename: Daniella
authors.initials: D
authors.lastname: Furman
authors.forename: Joseph
authors.initials: J
authors.lastname: Ledoux
authors.forename: Bruce
authors.initials: B
authors.lastname: McEwen
authors.forename: Emily
authors.initials: E
authors.lastname: Stern
authors.forename: David
authors.initials: D
authors.lastname: Silbersweig
mesh_terms: D000328:Adult; D004644:Emotions / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D008032:Limbic System / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000737:chemistry*; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
chemical_list: D006854:Hydrocortisone