title: Preparation and characterization of antioxidant nanospheres from multiple alpha-lipoic acid-containing compounds.
abstract: The purpose of this study was to prepare and characterize antioxidant nanospheres composed of multiple alpha-lipoic acid-containing compounds (mALAs). It was found that the nanospheres were remarkably stable under physiologic conditions, maintained the antioxidant property of alpha-lipoic acid, and could be destabilized oxidatively and enzymatically. The preparations were simple and highly reproducible providing a new strategy for the development of nanometer-sized antioxidant biomaterials. The nanospheres may find applications as antioxidant therapeutics and oxidation-responsive antioxidant nanocontainers in drug delivery for pathological conditions characterized by oxidative stress including cancer and neurodegenerative diseases.
authors.affiliation: Department of Neurosurgery, Cedars-Sinai Medical Center, 8631 W. Third Street, Suite 800 East, Los Angeles, CA 90048, USA.
authors.forename: Bong Seop
authors.initials: BS
authors.lastname: Lee
authors.forename: Xiangpeng
authors.initials: X
authors.lastname: Yuan
authors.forename: Qijin
authors.initials: Q
authors.lastname: Xu
authors.forename: Fred S
authors.initials: FS
authors.lastname: McLafferty
authors.forename: Brian A
authors.initials: BA
authors.lastname: Petersen
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Collette
authors.forename: Keith L
authors.initials: KL
authors.lastname: Black
authors.forename: John S
authors.initials: JS
authors.lastname: Yu
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry; D002621:Chemistry / Q000379:methods; D015195:Drug Design; D008956:Models, Chemical; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D010100:Oxygen / Q000737:chemistry; D013696:Temperature; D008063:Thioctic Acid / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000975:Antioxidants; D001672:Biocompatible Materials; D008063:Thioctic Acid; D010100:Oxygen