Terminal ileal atresia, total colonic aganglionosis, and thrombophilia.
Inherited thrombophilia, a predisposition for a hypercoagulable state, has been associated with cases of intestinal atresia. In this communication, we report a case of terminal ileal atresia and total colonic aganglionosis (Hirschsprung's disease), a rarely documented association, in a neonate who seemed to have a hypercoagulable state. The case stresses the need for recognition of this sequence of events in order to achieve optimal management.
de Chadarévian
Jean-Pierre
JP
Department of Pathology and Laboratory Medicine, Drexel University College of Medicine and St. Christopher's Hospital for Children, Philadelphia, PA, USA. J.deChadarevian@DrexelMed.edu
Bouie
Shondell M
SM
Peddinghaus
Marie E
ME
Luck
Lori R
LR
Schwartz
Marshall Z
MZ
Prasad
Rajeev
R
Faerber
Eric N
EN
D000015:Abnormalities, Multiple / Q000473:pathology*; D006627:Hirschsprung Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007082:Ileum / Q000002:abnormalities*; D007223:Infant; D007231:Infant, Newborn; D007409:Intestinal Atresia / Q000150:complications* / Q000473:pathology; D008297:Male; D019851:Thrombophilia / Q000150:complications / Q000151:congenital* / Q000473:pathology