title: [Nuchal translucency and ductus venosus as ultrasound markers of chromosomal abnormalities].
abstract: Chromosomal abnormalities are frequent pathologies. We must find new methods for early prenatal diagnosis. Therefore we propose to assess the effectiveness of nuchal translucency thickness and abnormal Doppler of ductus venosus as ultrasound markers of aneuploidies. We evaluated 228 high risk pregnancies between 11 and 14 weeks. Later amniocentesis or newborn evaluation by a genetist was made. 28 patients were lost at follow up; the definitive sample was 200 pregnancies. Nuchal translucency thickness was increased in 5 fetuses, of these 4 presented abnormal Doppler of ductus venosus. Chromosomal anomalies were confirmed in 3 of these fetuses, for an incidence of 1.5%. Nuchal translucency thickness increased had: 100% sensitivity and 98.98% specificity. Abnormal Doppler of ductus venosus had: 100% sensitivity and 99.49% specificity. Nuchal translucency thickness and Doppler of ductus venosus are excellent markers of chromosomal abnormalities
authors.affiliation: Universidad Central de Venezuela, Maternidad Concepción Palacios, Caracas, Venezuela.
authors.forename: Victor
authors.initials: V
authors.lastname: Díaz
authors.forename: Ramón
authors.initials: R
authors.lastname: Guevara
authors.forename: Julio
authors.initials: J
authors.lastname: Brito
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D002869:Chromosome Aberrations; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D005865:Gestational Age; D006801:Humans; D008099:Liver / Q000098:blood supply / Q000000981:diagnostic imaging; D048208:Nuchal Translucency Measurement / Q000379:methods*; D011247:Pregnancy; D012680:Sensitivity and Specificity; D014471:Umbilical Veins / Q000000981:diagnostic imaging* / Q000502:physiology; D014682:Vena Cava, Inferior / Q000000981:diagnostic imaging* / Q000502:physiology