title: Bypass specialists operate together.
abstract: New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (pol zeta) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.
authors.affiliation: Department of Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA.
authors.forename: Kei-ichi
authors.initials: K
authors.lastname: Takata
authors.forename: Richard D
authors.initials: RD
authors.lastname: Wood
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D004247:DNA / Q000737:chemistry; D018736:DNA Adducts / Q000737:chemistry; D004249:DNA Damage; D017931:DNA Primers / Q000737:chemistry; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism*; D019281:Dimerization; D006801:Humans; D008954:Models, Biological; D011743:Pyrimidines / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D018736:DNA Adducts; D017931:DNA Primers; D011743:Pyrimidines; D004247:DNA; D004259:DNA-Directed DNA Polymerase; C030986:pyrimidine