title: [Effect of obstructive sleep apnea syndrome on blood lipid and blood glucose in elderly hypertensive patients].
abstract: OBJECTIVE
  To investigate the effect of obstructive sleep apnea syndrome (OSAS) on blood lipid and blood glucose in elderly hypertensive patients.
  
  
  METHODS
  a One hundred and seven elderly hypertensive patients received examinations by polysomnography and according to the apnea-hypopnea index (AHI), the patients were divided into four groups, namely uncomplicated hypertension group (n=23) and 3 hypertension groups with mild (n=31), moderate (n=29) and severe (n=24) OSAS. The fasting and 2-hour postprandial plasma glucose, glycosylated hemoglobin (HbA1c), total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), Apo-A, and Apo-B of these patients were measured.
  
  
  RESULTS
  aCompared with the non-OSAS patients, all the OSAS patients showed increased fasting and 2-hour postprandial plasma glucose, HbA1c, TC, TG, LDL and TC/HDL, and the increments were statistically significant in severe OSAS patients (P<0.05). The level of HDL was lowered in the OSAS groups, showing significant difference between severe OSAS group and the non-OSAS group (P<0.05). Apo-A level was lowered and Apo-B increased in the OSAS groups, but the differences were not statistically significant (P>0.05).
  
  
  CONCLUSIONS
  OSAS may produce harmful affect on the blood glucose and blood lipids in elderly hypertensive patients.
authors.affiliation: Institute of Geriatrics, Guangdong Provincial People's Hospital/Guangdong Academy of Medical Sciences, Guangzhou 510080, China. zhshqing@21cn.com
authors.forename: Sheng-qing
authors.initials: SQ
authors.lastname: Zhuo
authors.forename: Xue-ping
authors.initials: XP
authors.lastname: Yang
authors.forename: Yong-chi
authors.initials: YC
authors.lastname: Chen
authors.forename: Xiang-ting
authors.initials: XT
authors.lastname: Tian
authors.forename: Huan
authors.initials: H
authors.lastname: Lian
authors.forename: Qiong
authors.initials: Q
authors.lastname: Ou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications*
chemical_list: D001786:Blood Glucose; D008055:Lipids