title: Protective effects of electroacupuncture on acetylsalicylic acid-induced acute gastritis in rats.
abstract: OBJECTIVE
  To investigate the protective effects of electroacupuncture (EA) pretreatment on acetylsalicylic acid (ASA)-induced ulceration in rats.
  
  
  METHODS
  We randomly divided 72 rats into three groups including control (administered with distilled water), ASA group (administered 100 mg/kg ASA) and EA group (administered EA + 100 mg/kg ASA). Each rat was fasted for 18 to 24 h before experimentation, and lesion scores, gastric acidity, cyclooxygenase (COX)-1 and -2 mRNA levels, and total nitric oxide (NO) concentration were measured.
  
  
  RESULTS
  The lesion scores of the EA group were significantly lower than those of the ASA group. Gastric acidity of the ASA and EA groups was reduced compared to the control group. COX-1 and -2 mRNA levels were significantly increased in the EA group as compared to the control and ASA groups, and NO levels were also significantly increased in the EA group as compared to the ASA group.
  
  
  CONCLUSIONS
  These results suggest that EA-mediated protection against ASA-induced ulceration in rats may occur via gastric defense components.
authors.affiliation: Department of Medical Research, Korea Institute of Oriental Medicine, 483 Exporo, Yuseong-Gu, Daejeon, South Korea.
authors.forename: Hye-Suk
authors.initials: HS
authors.lastname: Hwang
authors.forename: Kyung-Ju
authors.initials: KJ
authors.lastname: Han
authors.forename: Yeon-Hee
authors.initials: YH
authors.lastname: Ryu
authors.forename: Eun-Jin
authors.initials: EJ
authors.lastname: Yang
authors.forename: Yoo-Sung
authors.initials: YS
authors.lastname: Kim
authors.forename: Sang-Yong
authors.initials: SY
authors.lastname: Jeong
authors.forename: Young-Seop
authors.initials: YS
authors.lastname: Lee
authors.forename: Myeong-Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Sung-Tae
authors.initials: ST
authors.lastname: Koo
authors.forename: Sun-Mi
authors.initials: SM
authors.lastname: Choi
mesh_terms: D000818:Animals; D001241:Aspirin / Q000633:toxicity; D051545:Cyclooxygenase 1 / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics; D004195:Disease Models, Animal; D015671:Electroacupuncture / Q000379:methods*; D005744:Gastric Acid / Q000378:metabolism; D005756:Gastritis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D012333:RNA, Messenger; D009569:Nitric Oxide; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D001241:Aspirin