[Role of hypoxia-induced transcriptional factor HIF-1 in the regulation of enterocytic metabolism].
The mechanisms responsible for the induction of the desquamation and death of intestinal epithelial cells in the areas of extrusion in normalcy remain unknown so far. The author's ultrastructural data and the data available in the literature suggest that HIF-1 [corrected] may regulate these processes. Its activators may be both lower oxygen concentrations in the upper portions of the intestinal villus ("physiological hypoxia") and some nonhypoxic factors, such as LPS of the enteric microflora. On the one hand, HIF-1 is involved in adaptive processes, by mobilizing specifically cellular and tissue resources, and, on the other hand, it promotes the inclusion of the mechanisms of programmed cell death at a certain stage, by provoking the synthesis of the proapoptotic mitochondrial proteins BNIP3 and BNIP3L, which is morphologically manifested as different types of apoptotic and necrotic cell death.
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D000222:Adaptation, Physiological; D000818:Animals; D017209:Apoptosis; D020895:Enterocytes / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology*; D008070:Lipopolysaccharides / Q000378:metabolism; D008565:Membrane Proteins / Q000096:biosynthesis; D010100:Oxygen / Q000378:metabolism; D013552:Swine; D013556:Swine, Miniature; D015854:Up-Regulation
D051793:Hypoxia-Inducible Factor 1; D008070:Lipopolysaccharides; D008565:Membrane Proteins; D010100:Oxygen