A case of late-onset Tourette's disorder successfully treated with aripiprazole: view from blood levels of catecholamine metabolites and brain-derived neurotrophic factor (BDNF).
We reported a case with late-onset Tourette's disorder (TD) in whom motor tics and emotional instability improved with 18 mg/day of aripiprazole treatment. Plasma HVA levels, but not MHPG levels, were altered during the treatment. In contrast, serum BDNF levels remained consistently low during the treatment course. The present case suggests that aripiprazole might ameliorate tics and emotional instability via influencing dopaminergic neurons in late-onset TD.
Ikenouchi-Sugita
Atsuko
A
Department of Psychiatry, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan. atsuko-i@med.uoeh-u.ac.jp
Yoshimura
Reiji
R
Hayashi
Kenji
K
Ueda
Nobuhisa
N
Umene-Nakano
Wakako
W
Hori
Hikaru
H
Nakamura
Jun
J
D000367:Age Factors; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D000068180:Aripiprazole; D001921:Brain / Q000000981:diagnostic imaging; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D002395:Catecholamines / Q000097:blood / Q000378:metabolism*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D006801:Humans; D008297:Male; D010879:Piperazines / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use*; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D005879:Tourette Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D055815:Young Adult
D014150:Antipsychotic Agents; D019208:Brain-Derived Neurotrophic Factor; D002395:Catecholamines; D010879:Piperazines; D015363:Quinolones; D000068180:Aripiprazole