title: Prospective multicenter evaluation of rapid, gated SPECT myocardial perfusion upright imaging.
abstract: BACKGROUND
  A novel three-dimensional (3D) iterative image reconstruction method (3D-OSEM) has been developed that in phantom studies yielded comparable image quality at one half the imaging time. In this study, we compared standard (STD) and rapid (nSPEED) protocols for diagnostic quality of images and quantitation of end-diastolic volume (EDV), end-systolic volume (ESV), left ventricular ejection fraction (LVEF), and perfusion defect severity.
  
  
  METHODS
  At 11 US community centers, 448 patients prospectively underwent rest-stress-gated SPECT imaging using Tc-99m-labeled agent. The difference in quality and diagnostic equivalence of STD and nSPEED images were blindly evaluated by three experts. Defect intensity was quantitated as %normal in the three coronary artery territories.
  
  
  RESULTS
  Studies were abnormal in 40% of patients. In 98.7% of stress and 98% of rest images, the nSPEED image quality was identical to or better than the STD images. nSPEED images were diagnostically equivalent to the STD in 444/448 (99%) patients. A high correlation was observed between nSPEED and STD studies for measurement of EDV (Y = 0.957X, R (2) = 0.99), ESV (Y = 0.962X, R (2) = 0.99), and LVEF (Y = 1.005X, R (2) = 0.96). STD and nSPEED studies were not significantly different (P = ns) for quantitative perfusion defect severity.
  
  
  CONCLUSIONS
  Rapid, gated rest-stress myocardial perfusion upright SPECT imaging may be achieved without compromising perfusion and function information.
authors.affiliation: Departments of Molecular and Medical Pharmacology (Nuclear Medicine) and Medicine (Cardiology), David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. jmaddahi@mednet.ucla.edu
authors.forename: Jamshid
authors.initials: J
authors.lastname: Maddahi
authors.forename: Ricardo
authors.initials: R
authors.lastname: Mendez
authors.forename: John J
authors.initials: JJ
authors.lastname: Mahmarian
authors.forename: Gregory
authors.initials: G
authors.lastname: Thomas
authors.forename: Hetal
authors.initials: H
authors.lastname: Babla
authors.forename: Chuanyong
authors.initials: C
authors.lastname: Bai
authors.forename: Samia
authors.initials: S
authors.lastname: Arram
authors.forename: Peter
authors.initials: P
authors.lastname: Maffetone
authors.forename: Richard
authors.initials: R
authors.lastname: Conwell
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D003627:Data Interpretation, Statistical; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000639:trends*; D011187:Posture; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014481:United States; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*