Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies.
Neonatal thrombocytopenia or neutropenia may result from passive transfusion of maternally derived antibodies. Antibodies against platelet antigens are commonly associated with neonatal alloimmune thrombocytopenia (NAIT), and anti-neutrophil antibodies are frequently identified in alloimmune neonatal neutropenia (ANN). Combined alloimmune cytopenias in the newborn are rarely reported; even fewer reports document human leukocyte antigen (HLA) antibodies as a potential cause of neonatal thrombocytopenia or neutropenia. We describe neutropenia and thrombocytopenia in a newborn associated with markedly elevated maternal HLA antibodies in the absence of anti-neutrophil or anti-platelet antibodies to highlight consideration of HLA antibodies in the pathogenesis of ANN and NAIT.
Gramatges
M Monica
MM
Department of Pediatrics, Stanford University School of Medicine, Palo Alto, California 94107, USA.
Fani
Pauline
P
Nadeau
Kari
K
Pereira
Shalini
S
Jeng
Michael R
MR
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology*; D008297:Male; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D009503:Neutropenia / Q000151:congenital* / Q000276:immunology*; D011247:Pregnancy; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D006680:HLA Antigens; D007518:Isoantibodies