title: Cytokine and nitric oxide production in an adult patient with staphylococcal scalded skin syndrome.
abstract: Staphylococcal scalded-skin syndrome (SSSS) is an exfoliative dermatitis resultant from the infection with exfoliative-toxin-producing (ET) Staphylococcus aureus. This syndrome usually occurs in children, while adult cases are generally linked to renal-deficiency or immunossupresion. A case of a 74 year old woman presenting SSSS after hospital admission due to cardiovascular disorders is presented and discussed. Cytokines (TNF-alpha, IFN-gamma, IL-6, IL-13 and IL-10) and nitric oxide (NO) production in vitro by whole blood leukocytes (WBL) were investigated. Leukocytes stimulated by lipopolysaccharide or phytohemagglutinin produced increased IFN-gamma, TNF-alpha, IL-13 and NO levels after treatment. Based on these results, immunological aspects of the disease are discussed.
authors.affiliation: Laboratório de Imunologia, Universidade Federal do Triâingulo Mineiro, Uberaba, MG, Brasil. lucio@mednet.com.br
authors.forename: Lúcio Roberto
authors.initials: LR
authors.lastname: Castellano
authors.forename: David Nascimento
authors.initials: DN
authors.lastname: Silva-Teixeira
authors.forename: Elida J
authors.initials: EJ
authors.lastname: Antonelli
authors.forename: Virmondes
authors.initials: V
authors.lastname: Rodrigues
authors.forename: Maria Bernarda
authors.initials: MB
authors.lastname: Cavalcanti-Cordeiro
mesh_terms: D000368:Aged; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D018793:Interleukin-13 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D013206:Staphylococcal Scalded Skin Syndrome / Q000276:immunology / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D018793:Interleukin-13; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D009569:Nitric Oxide; D007371:Interferon-gamma