[Effect of vitamin A provision on antineoplastic resistance in rats].
While studying Guerin's carcinoma development under conditions of different vitamin A provision in the period of tumor growth and before it appearance, it was established, that strengthened saturation of an organism with a tumor by vitamin A hyper doses can both stimulate and inhibit tumor progression. The effect depends on duration of vitamin A administration and on the level of preliminary provision of an organism with this vitamin. The hyper doses administration for 7 days on the normal vitamin A provision background and the normal doses administration to vitamin A-deficient animals which is especially expressed antitumor effect. The continuation of hyper doses administration to 14 days leads to rising of tumor sizes, especially expressed in vitamin A-deficient animals.
Marchenko
M M
MM
Shmarakov
I A
IA
Pasaĭliuk
M V
MV
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004224:Diterpenes; D004305:Dose-Response Relationship, Drug; D019008:Drug Resistance, Neoplasm; D005260:Female; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000150:complications / Q000517:prevention & control*; D051381:Rats; D000084562:Retinyl Esters; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000150:complications*
D000970:Antineoplastic Agents; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate