Engineering parathyroid cells to treat secondary hyperparathyroidism.
Kanai et al. used antisense technology to reduce excessive PTH production. The authors have overcome technical difficulties to demonstrate that, by strategies of RNA interference, a steady reduction of PTH secretion can be induced in cultured parathyroid-cell spheroids and in athymic nude mice with hyperplastic parathyroid cells transplanted from patients with secondary hyperparathyroidism.
Rodríguez
Mariano
M
Unidad de Investigación, Servicio de Nefrología, Hospital Universitario Reina Sofía, Córdoba, Spain. juanm.rodriguez.sspa@juntadeandalucia.es
Martinez-Moreno
Julio M
JM
Almadén
Yolanda
Y
D000818:Animals; D018929:Cell Culture Techniques; D017690:Cell Transplantation; D015536:Down-Regulation / Q000235:genetics; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000628:therapy*; D051379:Mice; D010280:Parathyroid Glands / Q000166:cytology*; D010281:Parathyroid Hormone / Q000096:biosynthesis / Q000235:genetics; D034622:RNA Interference
D010281:Parathyroid Hormone