title: Total synthesis of (-)-amphidinolide K.
abstract: Macrolide magic: An enyne cross-metathesis reaction of an alkynyl boronate with an alkene derivative as well as a radical cyclization reaction of a homopropargylic beta-alkoxyacrylate are the key transformations in the total synthesis of the cytotoxic macrolide (-)-amphidinolide K.
authors.affiliation: Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Korea.
authors.forename: Haye Min
authors.initials: HM
authors.lastname: Ko
authors.forename: Chung Whan
authors.initials: CW
authors.lastname: Lee
authors.forename: Hyung Kyoo
authors.initials: HK
authors.lastname: Kwon
authors.forename: Hea Seung
authors.initials: HS
authors.lastname: Chung
authors.forename: Soo Young
authors.initials: SY
authors.lastname: Choi
authors.forename: Young Keun
authors.initials: YK
authors.lastname: Chung
authors.forename: Eun
authors.initials: E
authors.lastname: Lee
mesh_terms: D000475:Alkenes / Q000737:chemistry; D003500:Cyclization; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D000097442:Amphidinolides
chemical_list: D000475:Alkenes; D018942:Macrolides; C409107:amphidinolide K; D000097442:Amphidinolides