Evaluation of commercially available anti-dengue virus immunoglobulin M tests.
Anti-dengue virus immunoglobulin M kits were evaluated. Test sensitivities were 21%-99% and specificities were 77%-98% compared with reference ELISAs. False-positive results were found for patients with malaria or past dengue infections. Three ELISAs showing strong agreement with reference ELISAs will be included in the World Health Organization Bulk Procurement Scheme.
Hunsperger
Elizabeth A
EA
Serology Diagnostics and Viral Pathogenesis Research Section, Centers for Disease Control and Prevention, San Juan, Puerto Rico.
Yoksan
Sutee
S
Buchy
Philippe
P
Nguyen
Vinh Chau
VC
Sekaran
Shamala D
SD
Enria
Delia A
DA
Pelegrino
Jose L
JL
Vázquez
Susana
S
Artsob
Harvey
H
Drebot
Michael
M
Gubler
Duane J
DJ
Halstead
Scott B
SB
Guzmán
María G
MG
Margolis
Harold S
HS
Nathanson
Carl-Michael
CM
Rizzo Lic
Nidia R
NR
Bessoff
Kovi E
KE
Kliks
Srisakul
S
Peeling
Rosanna W
RW
D000914:Antibodies, Viral / Q000097:blood*; D003715:Dengue / Q000175:diagnosis* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005189:False Positive Reactions; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D011933:Reagent Kits, Diagnostic; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000914:Antibodies, Viral; D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic