title: Molecular targets for cancer chemoprevention.
abstract: Vaccines targeting infections with hepatitis B virus, a risk factor for hepatocellular cancer, and human papillomavirus, a risk factor for cervical cancer, are considered major clinical cancer chemoprevention successes. Molecularly targeted agents can prevent breast cancer (raloxifene and tamoxifen), colorectal adenomas (celecoxib), and prostate cancer (finasteride). Nevertheless, the broad translation of chemoprevention to the clinic is not yet a reality. Continuing research of molecular targets promises to expand the reach of chemoprevention and to personalize it as well.
authors.affiliation: Department of Thoracic/Head and Neck Medical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030, USA.
authors.forename: William N
authors.initials: WN
authors.lastname: William
authors.forename: John V
authors.initials: JV
authors.lastname: Heymach
authors.forename: Edward S
authors.initials: ES
authors.lastname: Kim
authors.forename: Scott M
authors.initials: SM
authors.lastname: Lippman
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control*; D012307:Risk Factors; D014612:Vaccines / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016588:Anticarcinogenic Agents; D014612:Vaccines