Total helical-sense bias of an achiral peptide main chain induced by a chiral side-chain bridge.
A single intramolecular cross-linking between the chiral side chains at the i and i + 3 positions induces only a one-handed helix in a 3(10)-helical peptide of which the main chain lacks a chiral center and, thus, transforms the "dynamic" helix to a "static" one.
Ousaka
Naoki
N
Japan Science and Technology Agency, ERATO-SORST Kuroda Chiromorphology Team, 4-7-6, Komaba, Meguro-ku, Tokyo 153-0041, Japan. ousaka@chiromor2.erato.rcast.u-tokyo.ac.jp
Sato
Tomohiro
T
Kuroda
Reiko
R
D003432:Cross-Linking Reagents; D010455:Peptides / Q000737:chemistry*; D017433:Protein Structure, Secondary; D013237:Stereoisomerism
D003432:Cross-Linking Reagents; D010455:Peptides