title: Elevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort.
abstract: There is considerable interest in identifying children at high risk for developing atopic diseases for primary prevention. This study evaluates risk factors for detectable cord blood IgE and assesses CB-IgE in predicting asthma and other IgE-mediated allergic diseases in children at high risk because of family history. Cord blood was obtained as part of a randomized controlled trial assessing the efficacy of an intervention program in the primary prevention of IgE-mediated allergic diseases. CB-IgE was measured and the degree to which this was associated with perinatal risk factors was assessed. The cohort was then evaluated for atopic disorders at 7 yrs of age to assess the predictive value of CB-IgE. Fifty-five (19.3%) of infants had detectable CB-IgE (>/=0.5 kU/l). Maternal atopy and birth in winter months were risk factors associated with detectable CB-IgE. CB-IgE was found to be significantly associated with allergic sensitization (OR 2.22; 95% CI 1.11, 4.41) and recurrent wheeze at 7 yrs (OR 2.51, 95% CI 1.09, 5.76) but not with other outcomes. CB-IgE may be a useful measure for identifying children at high risk of atopic diseases for the purpose of primary prevention.
authors.affiliation: Division of Allergy, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Alexander
authors.initials: A
authors.lastname: Ferguson
authors.forename: Helen
authors.initials: H
authors.lastname: Dimich-Ward
authors.forename: Allan
authors.initials: A
authors.lastname: Becker
authors.forename: Wade
authors.initials: W
authors.lastname: Watson
authors.forename: Anne
authors.initials: A
authors.lastname: DyBuncio
authors.forename: Chris
authors.initials: C
authors.lastname: Carlsten
authors.forename: Moira
authors.initials: M
authors.lastname: Chan-Yeung
mesh_terms: D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000453:epidemiology* / Q000517:prevention & control; D002170:Canada / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D042241:Early Diagnosis; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology* / Q000517:prevention & control; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D011322:Primary Prevention; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012135:Respiratory Sounds / Q000276:immunology*; D012307:Risk Factors
chemical_list: D000485:Allergens; D007073:Immunoglobulin E