title: Sulfated steroids: ptilosteroids A-C and ptilosaponosides A and B from the Solomon Islands marine sponge Ptilocaulis spiculifer.
abstract: Three new pregnanes, ptilosteroid A (1), ptilosteroid B (2), and ptilosteroid C (3), and two new pregnane glycosides, ptilosaponoside A (4) and ptilosaponoside B (5), were isolated from the marine sponge Ptilocaulis spiculifer collected in the Solomon Islands. The structures were determined by spectroscopic methods. Biological tests of these compounds showed that they are not cytotoxic against KB cells.
authors.affiliation: Institut de Chimie des Substances Naturelles du CNRS, Gif-sur-Yvette, France.
authors.forename: Marion
authors.initials: M
authors.lastname: Gabant
authors.forename: Isabelle
authors.initials: I
authors.lastname: Schmitz-Afonso
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Gallard
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Menou
authors.forename: Dominique
authors.initials: D
authors.lastname: Laurent
authors.forename: Cécile
authors.initials: C
authors.lastname: Debitus
authors.forename: Ali
authors.initials: A
authors.lastname: Al-Mourabit
mesh_terms: D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008386:Marine Biology; D008542:Melanesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D011278:Pregnanes; D012503:Saponins; D013463:Sulfuric Acid Esters; C540641:ptilosaponoside A; C540642:ptilosaponoside B; C540638:ptilosteroid A; C540639:ptilosteroid B; C540640:ptilosteroid C