title: Chlorogenic acid protects paraoxonase 1 activity in high density lipoprotein  from inactivation caused by physiological concentrations of hypochlorite.
abstract: We hypothesized that chlorogenic acids, the main phenolics in coffee, many fruits and Ilex paraguariensis extracts, protect paraoxonase 1 activity in HDL from inactivation by chlorination at concentrations of HOCl (50 microM) and chlorogenic acid (2-10 microM) compatible with those found in humans. When human HDL was incubated in the presence of HOCl/OCl-, a concentration dependent loss of activity was apparent. Of interest, 5 caffeoylquinic acid at 5 micromol/L affords more than 60% protection of the activity reaching 100% at 25 micromol/L. This compound and the plant sources that are rich in them may be protectors of paraoxonase 1 activity.
authors.affiliation: Glycation, Oxidation and Disease Laboratory, Touro University-California, Vallejo, CA 94592, USA. agugliuc@touro.edu
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gugliucci
authors.forename: Deborah H Markowicz
authors.initials: DH
authors.lastname: Bastos
mesh_terms: D043303:Aryldialkylphosphatase / Q000187:drug effects* / Q000378:metabolism; D002726:Chlorogenic Acid / Q000494:pharmacology*; D003069:Coffee; D006801:Humans; D006997:Hypochlorous Acid / Q000009:adverse effects*; D030019:Ilex paraguariensis; D008075:Lipoproteins, HDL / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*
chemical_list: D003069:Coffee; D008075:Lipoproteins, HDL; D010936:Plant Extracts; D020011:Protective Agents; D002726:Chlorogenic Acid; D006997:Hypochlorous Acid; D043303:Aryldialkylphosphatase