Sulfated steroids: ptilosteroids A-C and ptilosaponosides A and B from the Solomon Islands marine sponge Ptilocaulis spiculifer.
Three new pregnanes, ptilosteroid A (1), ptilosteroid B (2), and ptilosteroid C (3), and two new pregnane glycosides, ptilosaponoside A (4) and ptilosaponoside B (5), were isolated from the marine sponge Ptilocaulis spiculifer collected in the Solomon Islands. The structures were determined by spectroscopic methods. Biological tests of these compounds showed that they are not cytotoxic against KB cells.
Gabant
Marion
M
Institut de Chimie des Substances Naturelles du CNRS, Gif-sur-Yvette, France.
Schmitz-Afonso
Isabelle
I
Gallard
Jean-François
JF
Menou
Jean-Louis
JL
Laurent
Dominique
D
Debitus
Cécile
C
Al-Mourabit
Ali
A
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D008386:Marine Biology; D008542:Melanesia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013463:Sulfuric Acid Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D006027:Glycosides; D011278:Pregnanes; D012503:Saponins; D013463:Sulfuric Acid Esters; C540641:ptilosaponoside A; C540642:ptilosaponoside B; C540638:ptilosteroid A; C540639:ptilosteroid B; C540640:ptilosteroid C