A case of optic neuropathy after short-term linezolid use in a patient with acute lymphocytic leukemia.
A patient undergoing chemotherapy for treatment of acute lymphocytic leukemia developed septicemia that was treated with linezolid for 16 days. The patient subsequently reported reduced vision in both eyes and was found to have bilateral optic neuropathy. After the discontinuation of linezolid treatment, both the optic neuropathy and visual impairment resolved without sequelae.
Joshi
Lavnish
L
Multidisciplinary Vasculitis Clinic, Imperial College Healthcare National Health Service Trust, Hammersmith Hospital, London, United Kingdom.
Taylor
Simon R J
SR
Large
Oliver
O
Yacoub
Sophie
S
Lightman
Susan
S
D000081:Acetamides / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000069349:Linezolid; D009901:Optic Nerve Diseases / Q000139:chemically induced*; D023303:Oxazolidinones / Q000009:adverse effects* / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D018805:Sepsis / Q000188:drug therapy*; D055815:Young Adult
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid