title: Intestinal intussusception due to a pyogenic granuloma.
abstract: Pyogenic granuloma (PG), also known as lobular capillary hemangioma, is a benign vascular tumor, most commonly arising on the skin and the oral mucosa. Gastrointestinal localization of PG, except for the oral cavity, is exceptionally rare. We describe a case of ileal PG occurring in a 13-year-old girl, presenting with intestinal obstruction. Histological examination revealed proliferation of capillary-sized vessels, with prominent intravascular component, involving the entire thickness of the intestinal wall. Immunohistochemistry showed positivity for CD31, CD34 and von Willebrand factor, whereas immunostaining for glucose transporter-1 protein (GLUT1) and for human herpes virus 8 (HHV-8) was negative. We suggest that PG should be considered in the differential diagnosis of childhood gastrointestinal polypoid lesions.
authors.affiliation: Institute of Pathology, University of Belgrade, Serbia.
authors.forename: Zorica
authors.initials: Z
authors.lastname: Stojsic
authors.forename: Dimitrije
authors.initials: D
authors.lastname: Brasanac
authors.forename: George
authors.initials: G
authors.lastname: Kokai
authors.forename: Dragana
authors.initials: D
authors.lastname: Vujovic
authors.forename: Dragana
authors.initials: D
authors.lastname: Zivanovic
authors.forename: Ivan
authors.initials: I
authors.lastname: Boricic
authors.forename: Dragoljub
authors.initials: D
authors.lastname: Bacetic
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D017789:Granuloma, Pyogenic / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007443:Intussusception / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery