[Morphological characteristics of the testicles of male Wistar rats intoxicated with morphine].
Experimental study of the effect of morphine on reproductive organs was made in Wistar rats. In the experimental animals from Group 1, 1% morphine solution was intraperitoneally injected in increasing doses during 10 days while in Group 2 animals were taught to administer morphine themselves during 28 days. Morphological and morphometric studies were conducted. The plasma levels of follicle-stimulating hormone, luteinizing hormone, corticosterone, testosterone, and estradiol were measured by enzyme immunoassay. It was ascertained that there was a progressive inhibition of both hormonopoietic and spermatogenic functions depending on the duration of morphine use.
Mkhitarov
V A
VA
Lun'kova
L K
LK
D000818:Animals; D003345:Corticosterone / Q000097:blood; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013091:Spermatogenesis; D013737:Testis / Q000187:drug effects* / Q000473:pathology*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D004958:Estradiol; D009020:Morphine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D003345:Corticosterone