title: Genome stability roles of SUMO-targeted ubiquitin ligases.
abstract: Post-translational modification of the cell's proteome by ubiquitin and ubiquitin-like proteins provides dynamic functional regulation. Ubiquitin and SUMO are well-studied post-translational modifiers that typically impart distinct effects on their targets. The recent discovery that modification by SUMO can target proteins for ubiquitination and proteasomal degradation sets a new paradigm in the field, and offers insights into the roles of SUMO and ubiquitin in genome stability.
authors.affiliation: Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: J
authors.initials: J
authors.lastname: Heideker
authors.forename: J J P
authors.initials: JJ
authors.lastname: Perry
authors.forename: M N
authors.initials: MN
authors.lastname: Boddy
mesh_terms: D000818:Animals; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000378:metabolism; D004261:DNA Replication; D042822:Genomic Instability; D006801:Humans; D020935:MAP Kinase Signaling System; D011499:Protein Processing, Post-Translational; D025841:Small Ubiquitin-Related Modifier Proteins / Q000502:physiology*; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000502:physiology*; D054875:Ubiquitination
chemical_list: D025841:Small Ubiquitin-Related Modifier Proteins; D025801:Ubiquitin; D004247:DNA; D044767:Ubiquitin-Protein Ligases; D045643:DNA Repair Enzymes