STAT3 induces muscle stem cell differentiation by interaction with myoD.
Signal transducers and activators of transcription (STAT) family proteins transduce pivotal biological effects of various cytokines and hormones. STAT3 proteins are known to play a central role in the regulation of growth, differentiation, and survival of many types of cells. However, the function of STAT3 in myogenesis still remains largely unknown. We now provided direct evidence that STAT3 could induce myogenic differentiation and this effect might be mediated by interaction with MyoD--the essential transcription factor during myogenic differentiation. Furthermore, leukemia inhibitory factor (LIF) might be the upstream factor which activated JAK2/STAT3 pathway to stimulate muscle cell differentiation. Taken together, these results provide a molecular basis for further understanding of the muscle regeneration mechanism.
Yang
Yanping
Y
Department of Hematology and Oncology, The First Hospital, Jilin University, 71 Xinmin Street, Changchun 130021, China.
Xu
Ying
Y
Li
Wei
W
Wang
Guanjun
G
Song
Yanqiu
Y
Yang
Guozi
G
Han
Xue
X
Du
Zhonghua
Z
Sun
Luguo
L
Ma
Kewei
K
D000818:Animals; D002454:Cell Differentiation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D053614:Janus Kinase 2 / Q000378:metabolism; D053605:Leukemia Inhibitory Factor / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009132:Muscles / Q000166:cytology* / Q000473:pathology; D017570:MyoD Protein / Q000378:metabolism*; D010766:Phosphorylation; D011485:Protein Binding; D012038:Regeneration; D050796:STAT3 Transcription Factor / Q000378:metabolism / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology*; D020032:Tyrphostins / Q000494:pharmacology
D004791:Enzyme Inhibitors; D053605:Leukemia Inhibitory Factor; D017570:MyoD Protein; C057363:MyoD1 myogenic differentiation protein; D050796:STAT3 Transcription Factor; C494087:Stat3 protein, mouse; D020032:Tyrphostins; C095512:alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide; C507926:Jak2 protein, mouse; D053614:Janus Kinase 2