title: [Elimination of inflammatory mediators in sepsis by means of sorption detoxification methods].
abstract: The levels of pro- and anti-inflammatory cytokines were studied in 31 patients with sepsis of varying etiology; in 17 patients of them hemosorption through the antiproteinase sorbent Ovosorb was included into a complex of traditional intensive care, in 14 patients hemocarboperfusion was made through the carbon hemosorbent Simplex-F. The sorption detoxification methods were found to cause a reduction in the excessive levels of blood inflammatory cytokines, the hemosorbent Ovosorb showing the most pronounced eliminating effect. At the same time, there was an increase in the blood level of anti-inflammatory mediators in patients on Ovosorb hemosorption. This effect in regulating pro- and anti-inflammatory cytokines was absent when hemocarboperfusion was applied.
authors.forename: R E
authors.initials: RE
authors.lastname: Iakubtsevich
authors.forename: V V
authors.initials: VV
authors.lastname: Spas
authors.forename: I A
authors.initials: IA
authors.lastname: Shapel'
authors.forename: O E
authors.initials: OE
authors.lastname: Kuznetsov
mesh_terms: D018806:APACHE; D016207:Cytokines / Q000097:blood; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008875:Middle Aged; D018805:Sepsis / Q000097:blood / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D016060:Sorption Detoxification / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators