title: A reevaluation of the ambident reactivity of the guanine moiety towards hydroxyl radicals.
abstract: Radically different: Contrary to previous proposals, the main reaction of the HO(*) radical with guanosine or 2'-deoxyguanosine is the hydrogen abstraction from the NH(2) moiety to give a guanyl radical. This radical, characterized by a broad band in the visible region (around 610 nm), undergoes tautomerization to the most stable isomer.
authors.affiliation: ISOF, Consiglio Nazionale delle Ricerche, Via P. Gobetti 101, 40129 Bologna, Italy. chrys@isof.cnr.it
authors.forename: Chryssostomos
authors.initials: C
authors.lastname: Chatgilialoglu
authors.forename: Mila
authors.initials: M
authors.lastname: D'Angelantonio
authors.forename: Maurizio
authors.initials: M
authors.lastname: Guerra
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kaloudis
authors.forename: Quinto G
authors.initials: QG
authors.lastname: Mulazzani
mesh_terms: D003849:Deoxyguanosine / Q000737:chemistry; D006147:Guanine / Q000737:chemistry*; D017665:Hydroxyl Radical / Q000737:chemistry*
chemical_list: D017665:Hydroxyl Radical; D006147:Guanine; D003849:Deoxyguanosine