Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice.
Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 deficiency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.
Ikeno
Yuji
Y
Barshop Institute for Longevity and Aging Studies, San Antonio, TX 78245-3207, USA. ikeno@uthscsa.edu
Hubbard
Gene B
GB
Lee
Shuko
S
Cortez
Lisa A
LA
Lew
Christie M
CM
Webb
Celeste R
CR
Berryman
Darlene E
DE
List
Edward O
EO
Kopchick
John J
JJ
Bartke
Andrzej
A
D000375:Aging / Q000378:metabolism*; D000818:Animals; D015994:Incidence; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000378:metabolism*; D011986:Receptors, Somatotropin / Q000378:metabolism*
D011986:Receptors, Somatotropin; C519530:insulin-like growth factor-1, mouse; D007334:Insulin-Like Growth Factor I