YY1 Over-expression in human brain gliomas and meningiomas correlates with TGF-beta1, IGF-1 and FGF-2 mRNA levels.
In this study we examined by QRT-PCR the mRNA expression of TGF-beta 1, IGF-1, EGF, FGF-2 and YY1 in human brain tumors. Our findings introduce YY1, for the first time, as a novel gene implicated in brain gliomatogenesis and meningioma establishment. We present a positive correlation between the autocrine expression of YY1 and TGF-beta 1, IGF-1 and FGF-2, known to be involved in the progression of gliomas and meningiomas. We suggest that mRNA profiling of the above genes in the early stages of disease development could be useful for prognostic purposes, and these genes can be considered as potential targets for therapeutic approaches against brain tumors.
Baritaki
Stavroula
S
Department of Clinical Virology, Medical School, University of Crete, Crete, Greece. sbaritak@ucla.edu
Chatzinikola
Anthoula M
AM
Vakis
Antonios F
AF
Soulitzis
Nikolaos
N
Karabetsos
Dimitris A
DA
Neonakis
Ioannis
I
Bonavida
Benjamin
B
Spandidos
Demetrios A
DA
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000209:etiology / Q000378:metabolism*; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000235:genetics*; D005910:Glioma / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics*; D008297:Male; D008579:Meningioma / Q000209:etiology / Q000378:metabolism*; D008875:Middle Aged; D012333:RNA, Messenger / Q000032:analysis*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D050986:YY1 Transcription Factor / Q000235:genetics*
D012333:RNA, Messenger; D053773:Transforming Growth Factor beta1; D050986:YY1 Transcription Factor; C494698:YY1 protein, human; D016222:Fibroblast Growth Factor 2; D007334:Insulin-Like Growth Factor I