Effects of the introduction of inversion of polarity sites in the quadruplex forming oligonucleotide TGGGT.
Insight into the influence of inversion of polarity sites on the structural features of quadruplex structures is presented. The NMR and CD studies concern modified oligodeoxynucleotides (ODNs) based on the quadruplex forming sequence TGGGT. The presence of inversion of polarity sites not only does not compromise the formation of quadruplexes, but in some cases it increases the thermal stability of modified complexes compared with that of the unmodified one.
Esposito
Veronica
V
Dipartimento di Chimica delle Sostanze Naturali,Università degli Studi di Napoli Federico II, Napoli, Italy.
Virgilio
Antonella
A
Pepe
Antonietta
A
Oliviero
Giorgia
G
Mayol
Luciano
L
Galeone
Aldo
A
D001483:Base Sequence; D002942:Circular Dichroism; D054856:G-Quadruplexes; D006027:Glycosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000737:chemistry*; D044366:Transition Temperature
D006027:Glycosides; D009838:Oligodeoxyribonucleotides