title: Synthesis of 3,4-disubstituted maleimides by selective cross-coupling reactions using indium organometallics.
abstract: Unsymmetrical 3,4-disubstituted maleimides have been synthesized by palladium-catalyzed cross-coupling reactions of indium organometallics with 3,4-dihalomaleimides. The synthesis was performed by stepwise or sequential one-pot palladium-catalyzed cross-coupling reactions with various triorganoindium reagents. This method was used to prepare a wide variety of alkyl, aryl, heteroaryl, and alkynyl 3,4-disubstituted maleimides in good yields and with high selectivity and atom economy.
authors.affiliation: Departamento de Química Fundamental, Universidade da Coruña, E-15071 A Coruña, Spain.
authors.forename: Latifa
authors.initials: L
authors.lastname: Bouissane
authors.forename: José
authors.initials: J
authors.lastname: Pérez Sestelo
authors.forename: Luis A
authors.initials: LA
authors.lastname: Sarandeses
mesh_terms: D020650:Combinatorial Chemistry Techniques; D007204:Indium / Q000737:chemistry*; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry
chemical_list: D008301:Maleimides; D009942:Organometallic Compounds; D007204:Indium; D010165:Palladium