Aromatase inhibitory, radical scavenging, and antioxidant activities of depsidones and diaryl ethers from the endophytic fungus Corynespora cassiicola L36.
Isolation of a broth extract of the endophytic fungus Corynespora cassiicola L36 afforded three compounds, corynesidones A (1) and B (3), and corynether A (5), together with a known diaryl ether 7. Compounds 1, 3, 5, and 7 were relatively non-toxic against cancer cells, and inactive toward normal cell line, MRC-5. Corynesidone B (3) exhibited potent radical scavenging activity in the DPPH assay, whose activity was comparable to ascorbic acid. Based on the ORAC assay, compounds 1, 3, 5, and 7 showed potent antioxidant activity. However, the isolated natural substances and their methylated derivatives (1-8) neither inhibited superoxide anion radical formation in the XXO assay nor suppressed TPA-induced superoxide anion generation in HL-60 cell line. Corynesidone A (1) inhibited aromatase activity with an IC(50) value of 5.30 microM.
Chomcheon
Porntep
P
Chulabhorn Research Institute, Vibhavadi-Rangsit Highway, Laksi, Bangkok 10210, Thailand.
Wiyakrutta
Suthep
S
Sriubolmas
Nongluksna
N
Ngamrojanavanich
Nattaya
N
Kengtong
Surapong
S
Mahidol
Chulabhorn
C
Ruchirawat
Somsak
S
Kittakoop
Prasat
P
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification; D047072:Aromatase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification; D001203:Ascomycota / Q000737:chemistry*; D045744:Cell Line, Tumor; D053630:Depsides / Q000737:chemistry* / Q000302:isolation & purification; D004987:Ethers / Q000737:chemistry* / Q000302:isolation & purification; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization
D000975:Antioxidants; D047072:Aromatase Inhibitors; D053630:Depsides; D004987:Ethers; D016166:Free Radical Scavengers; D007783:Lactones; C000875:depsidone