Acquired hepatocerebral degeneration.
Cirrhosis and its co-morbidities may cause a variety of neurological complications, the most common being bouts of toxic metabolic encephalopathy. A proportion of patients with chronic liver disease develop acquired hepatocerebral degeneration (AHD), a chronic progressive neurological syndrome characterized by parkinsonism, ataxia and other movement disorders. This article reviews the clinical spectrum, pathophysiology, neuroimaging features and differential diagnosis of AHD along with emerging treatment options.
Ferrara
Joseph
J
Dept. of Neurology, Baylor College of Medicine, 6550 Fannin, Suite 1801, Houston, Texas 77030, USA.
Jankovic
Joseph
J
D000368:Aged; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005260:Female; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008107:Liver Diseases / Q000150:complications*