ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks.
We have developed ClueGO, an easy to use Cytoscape plug-in that strongly improves biological interpretation of large lists of genes. ClueGO integrates Gene Ontology (GO) terms as well as KEGG/BioCarta pathways and creates a functionally organized GO/pathway term network. It can analyze one or compare two lists of genes and comprehensively visualizes functionally grouped terms. A one-click update option allows ClueGO to automatically download the most recent GO/KEGG release at any time. ClueGO provides an intuitive representation of the analysis results and can be optionally used in conjunction with the GOlorize plug-in.
Bindea
Gabriela
G
INSERM, AVENIR Team, Integrative Cancer Immunology, U872, Paris, France.
Mlecnik
Bernhard
B
Hackl
Hubert
H
Charoentong
Pornpimol
P
Tosolini
Marie
M
Kirilovsky
Amos
A
Fridman
Wolf-Herman
WH
Pagès
Franck
F
Trajanoski
Zlatko
Z
Galon
Jérôme
J
D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D053263:Gene Regulatory Networks; D008954:Models, Biological; D005810:Multigene Family; D012984:Software