[Prevention and treatment of experimental liver fibrosis in rats by Semen Hoveniae extracts].
OBJECTIVE
To investigate the prevention and treatment of experimental liver fibrosis in rats by Semen Hoveniae extracts (SHE).


METHODS
Rats liver fiborsis model was induced by carbon tetrachloride (CCl4). SD rats were randomly divided into six groups: the normal control group, the model control group, the positive control group and the SHE groups. The level of serum procollgan type-III (PC-III), hyaluronic acid (HA), laminin (LN) and liver function were measured, respectively. Liver histological examination was made.


RESULTS
SHE could ameliorate CCl4-induced liver fibrosis significantly. The lever of serum PC-III, HA, LN decreased and liver function was improved. The histological examination also demonstrated its anti-fibrotic effect.


CONCLUSIONS
SHE have anti-fibrotic effect on liver in vivo, and may have potential value for clinical use.
Geng
Wen-Xue
WX
Department of Internal Medicine, People's Hospital of You Qian Qi, Wulanhaote 137400, China.
Ding
Hong-Yi
HY
Yi
Yun-Su
YS
D000818:Animals; D015415:Biomarkers / Q000097:blood*; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride; D024061:Collagen Type III / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008099:Liver / Q000473:pathology; D008106:Liver Cirrhosis, Experimental / Q000097:blood / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry; D020011:Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D031957:Ziziphus / Q000737:chemistry
D015415:Biomarkers; D024061:Collagen Type III; D004365:Drugs, Chinese Herbal; D007797:Laminin; D020011:Protective Agents; D006820:Hyaluronic Acid; D002251:Carbon Tetrachloride