Chrysin, a natural flavone, improves murine inflammatory bowel diseases.
Chrysin (5,7-dihydroxyflavone) is a natural flavone commonly found in many plants. It has previously been shown to be an anti-tumor agent. In this study, we investigated whether chrysin could alleviate the symptoms of dextran sodium sulfate (DSS)-induced colitis in mice and whether chrysin has an inhibitory effect on nuclear factor (NF)-kappaB activation in vitro. A significant blunting of weight loss and clinical signs was observed in DSS-exposed, chrysin-treated mice when compared to vehicle-treated mice. This was associated with a remarkable amelioration of the disruption of the colonic architecture, a significant reduction in colonic myeloperoxidase (MPO) activity, and a decrease in the production of inflammatory mediators such as nitric oxide (NO), prostaglandin (PG) E(2), and pro-inflammatory cytokines. In addition, chrysin inhibited tumor necrosis factor (TNF)-alpha-induced activation of NF-kappaB in IEC-6 cells. These findings suggest that chrysin exerts potentially clinically useful anti-inflammatory effects mediated through the suppression of NF-kappaB activation.
Shin
Eun Kyung
EK
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, GangwonDo, Republic of Korea.
Kwon
Hyuck-Se
HS
Kim
Yoon Hee
YH
Shin
Hyun-Kyung
HK
Kim
Jin-Kyung
JK
D000818:Animals; D003106:Colon / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D016264:Dextran Sulfate / Q000633:toxicity; D004195:Disease Models, Animal; D005419:Flavonoids / Q000627:therapeutic use*; D020672:I-kappa B Proteins / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D021381:Protein Transport / Q000187:drug effects; D015431:Weight Loss / Q000187:drug effects
D005419:Flavonoids; C083487:I kappa B beta protein; D020672:I-kappa B Proteins; D018836:Inflammation Mediators; C043561:chrysin; D016264:Dextran Sulfate