The ameliorative effect of black tea extract and quercetin on bisphenol A-induced cytotoxicity.
The purpose of our study was, to explore the possible ameliorating effects of black tea extract and quercetin, against bisphenol A-induced cytotoxicity. For this, human red blood corpuscles (RBC) were taken as the model. Blood samples collected in EDTA vials from healthy adults were used for preparation of RBC suspension. This suspension was treated with bisphenol A (0-150 microg/mL) with and without black tea extract or quercetin (0-200 microg/mL). The results showed that addition of bisphenol A causes concentration-dependent increase in rate of hemolysis. Addition of black tea extract or quercetin alone to RBC suspension did not cause any significant reduction. However, concurrent addition of bisphenol A (0-150 microg/mL) and black tea extract or quercetin caused concentration-dependent amelioration in bisphenol A-induced cytotoxicity.
Verma
Ramtej J
RJ
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad-380 009, India. ramtejverma2000@yahoo.com
Sangai
Neha P
NP
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D001559:Benzhydryl Compounds; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D010636:Phenols / Q000008:administration & dosage / Q000633:toxicity; D010936:Plant Extracts / Q000494:pharmacology*; D011794:Quercetin / Q000008:administration & dosage / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D000098826:Bisphenol A Compounds
D000975:Antioxidants; D001559:Benzhydryl Compounds; D010636:Phenols; D010936:Plant Extracts; D011794:Quercetin; D013662:Tea; C006780:bisphenol A; D000098826:Bisphenol A Compounds