title: Quantitative trait loci for porcine white blood cells and platelet-related traits in a White Duroc x Erhualian F resource population.
abstract: White blood cell count and platelets are implicated as risk factors for common complex diseases. Genetic factors substantially affect these traits in humans and mice. However, little is known about the genetic architecture of these traits in pigs. To identify quantitative trait loci (QTL) for leucocyte- and platelet-related traits in pigs, the total leucocyte number and differential leucocyte counts including the fraction of basophils, eosinophils, lymphocytes, monocytes, neutrophils, and a series of platelet parameters including platelet count, mean platelet volume, platelet distribution width and plateletcrit were measured in 1033 F(2) animals on 240 days from a White Duroc x Erhualian intercross resource population. A total of 183 informative microsatellites distributed across 19 pig chromosomes (SSC) were genotyped across the entire resource population. Thirty-three QTL were identified for the examined traits, including eight genome-wide significant QTL for white blood cells and differential leucocyte counts on SSC2, 7, 8, 12 and 15 and six significant QTL for platelet-related traits on SSC2, 8, 13 and X. Erhualian or White Duroc alleles were not systematically associated with increased phenotypic values. These results not only confirmed many QTL identified previously in the mouse and swine, but also revealed a number of novel QTL for the traits recorded. Moreover, it is the first time that QTL for platelet-related traits in pigs have been reported.
authors.affiliation: Key Laboratory for Animal Biotechnology of Jiangxi Province and the Ministry of Agriculture of China, Jiangxi Agricultural University, Nanchang, China.
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: X
authors.initials: X
authors.lastname: Yan
authors.forename: X
authors.initials: X
authors.lastname: Huang
authors.forename: Z
authors.initials: Z
authors.lastname: Zou
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: B
authors.initials: B
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Huang
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D055106:Genome-Wide Association Study; D005838:Genotype; D007958:Leukocyte Count / Q000662:veterinary; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D010976:Platelet Count / Q000662:veterinary; D016133:Polymerase Chain Reaction; D040641:Quantitative Trait Loci / Q000502:physiology*; D013552:Swine / Q000097:blood* / Q000235:genetics
chemical_list: D004247:DNA