title: STOP proteins contribute to the maturation of the olfactory system.
abstract: Regulation of microtubule dynamics is crucial for axon growth and guidance as well as for the establishment of synaptic connections. STOPs (Stable Tubule Only Polypeptides) are microtubule-associated proteins that regulate microtubule stabilization but are also able to interact with actin or Golgi membranes. Here, we have investigated the involvement of STOPs during the development of the olfactory system. We first describe the spatio-temporal expression patterns of N- and E-STOP, the two neuronal-specific isoforms of STOP. E- and N-STOP are expressed in the axonal compartment of olfactory sensory neurons, but are differentially regulated during development. Interestingly, each neuronal isoform displays a specific gradient distribution within the olfactory nerve layer. Then, we have examined the development of the olfactory system in the absence of STOPs. Olfactory axons display a normal outgrowth and targeting in STOP-null mice, but maturation of the synapses in the glomerular neuropil is altered.
authors.affiliation: Laboratoire Neurosciences Sensorielles, Comportement, Cognition, CNRS-UMR 5020, Université de Lyon, Lyon 1, F-69366, France. marion.richard@yale.edu
authors.forename: Marion
authors.initials: M
authors.lastname: Richard
authors.forename: Joëlle
authors.initials: J
authors.lastname: Sacquet
authors.forename: Marion
authors.initials: M
authors.lastname: Jany
authors.forename: Annie
authors.initials: A
authors.lastname: Schweitzer
authors.forename: François
authors.initials: F
authors.lastname: Jourdan
authors.forename: Annie
authors.initials: A
authors.lastname: Andrieux
authors.forename: Véronique
authors.initials: V
authors.lastname: Pellier-Monnin
mesh_terms: D000818:Animals; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D009833:Olfactory Pathways / Q000502:physiology*; D018034:Olfactory Receptor Neurons / Q000166:cytology / Q000502:physiology; D011247:Pregnancy; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D046509:Tissue Culture Techniques; D019147:Vomeronasal Organ / Q000166:cytology / Q000502:physiology
chemical_list: C113727:Map6 protein, rat; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms