title: Stir bar sorptive extraction-gas chromatography-mass spectrometry analysis of tetramethylene disulfotetramine in food: Method development and comparison to solid-phase microextraction.
abstract: A stir bar sorptive extraction-gas chromatography-mass spectrometry (SBSE-GC-MS) method for the determination of tetramethylene disulfotetramine is presented. The limits of detection (LOD) of the optimized method was 0.2ngg(-1) for extractions from water and 0.3-2.1ngg(-1) for extractions from foods. Recovery was highly matrix dependent (36-130%) and quantification required standard addition calibrations. Standard addition calibration lines had high linearity (R(2)>0.97) and replicate extractions had good reproducibility (R.S.D.=4.4-9.8%). A comparison of the SBSE method and a previously developed headspace (HS)-solid-phase microextraction (SPME) method was performed. Generally, SBSE provided higher sensitivity with decreased analysis time.
authors.affiliation: Center for Food Safety and Applied Nutrition, US Food and Drug Administration, 5100 Paint Branch Parkway, College Park, MD 20740, USA. lowri.dejager@fda.hhs.gov
authors.forename: Lowri S
authors.initials: LS
authors.lastname: De Jager
authors.forename: Gracia A
authors.initials: GA
authors.lastname: Perfetti
authors.forename: Gregory W
authors.initials: GW
authors.lastname: Diachenko
mesh_terms: D001952:Bridged-Ring Compounds / Q000032:analysis* / Q000302:isolation & purification; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D052617:Solid Phase Microextraction / Q000379:methods*
chemical_list: D001952:Bridged-Ring Compounds; C010349:tetramethylenedisulfotetramine