title: Assessment of patient and caregiver experiences of dementia-related symptoms: development of the Multidimensional Assessment of Neurodegenerative Symptoms questionnaire.
abstract: BACKGROUND
  To provide preliminary validation data on a self- or informant-report multidimensional questionnaire of symptoms associated with neurodegenerative disorders.
  
  
  METHODS
  Participants from 2 trials (n = 125), the Arizona APOE Cohort and the Arizona Alzheimer's Disease Center, completed the Multidimensional Assessment of Neurodegenerative Symptoms questionnaire (MANS) and other related measures.
  
  
  RESULTS
  Measures of central tendency are provided for the sample as a whole and by cognitive status. Internal consistency of the MANS is excellent (alpha = 0.98). Factor analysis suggests 4 factors. Correlational analyses support the construct validity of the MANS with moderate to high (r = 0.54-0.87) correlations between the MANS and measures of mood, cognition and daily functioning.
  
  
  CONCLUSIONS
  Results provide initial support for the MANS as a brief measure that is a reliable and valid indicator of cognitive, personality, functional and motor symptoms potentially related to neurodegenerative etiologies. Further research with the MANS is warranted.
authors.affiliation: Division of Psychology, Mayo Clinic, Scottsdale, AZ 85259, USA. locke.dona@mayo.edu
authors.forename: Dona E C
authors.initials: DE
authors.lastname: Locke
authors.forename: Kara B
authors.initials: KB
authors.lastname: Dassel
authors.forename: Geri
authors.initials: G
authors.lastname: Hall
authors.forename: Leslie C
authors.initials: LC
authors.lastname: Baxter
authors.forename: Bryan K
authors.initials: BK
authors.lastname: Woodruff
authors.forename: Charlene
authors.initials: C
authors.lastname: Hoffman Snyder
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Caselli
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001057:Apolipoproteins E / Q000235:genetics; D001130:Arizona / Q000453:epidemiology; D017028:Caregivers / Q000523:psychology*; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D003704:Dementia / Q000235:genetics / Q000523:psychology*; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000523:psychology*; D010361:Patients; D011569:Psychiatric Status Rating Scales; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires
chemical_list: D001057:Apolipoproteins E