Mortality and serum insulin-like growth factor (IGF)-I and IGF binding protein 3 concentrations.
BACKGROUND
Previous studies provided conflicting results regarding the association of serum IGF-I or IGF-binding protein-3 (IGFBP-3) and mortality. The aim of this study was to assess the relation of IGF-I and IGFBP-3 levels with mortality from all causes, cardiovascular disease (CVD), and cancer in a prospective population-based study.


METHODS
From the Study of Health in Pomerania (SHIP) 1988 men and 2069 women aged 20-79 yr were followed up on average 8.5 yr. Causes of deaths were coded according to the International Classification of Diseases, 10th revision. Serum IGF-I and IGFBP-3 levels were determined by chemiluminescence immunoassays and categorized into three groups (low, normal, high) according to the sex- and age-specific 10th and 90th percentiles.


RESULTS
Adjusted analyses revealed that men with low but not high IGF-I levels had an almost 2-fold higher risk of all-cause mortality [hazard ratio (HR) 1.92 (95% confidence interval [CI] 1.35; 2.73)], CVD mortality [HR 1.92 (95% CI 1.00; 3.71)], and cancer mortality [HR 1.85 (95% CI 1.00; 3.45)] compared with men with normal IGF-I levels. In women, no association between IGF-I and mortality was found. Moreover, low IGFBP-3 levels were associated with higher all-cause mortality in men [HR 1.87 (95% CI 1.31; 2.64)] and women [HR 1.63 (95% CI 0.96; 2.76)].


CONCLUSIONS
The present study found inverse associations between IGF-I or IGFBP-3 levels and mortality from all causes, CVD, or cancer in men and between IGFBP-3 and all-cause mortality in women.
Friedrich
Nele
N
Institute for Community Medicine, Ernst Moritz Arndt University, D-17487 Greifswald, Germany. nele.friedrich@uni-greifswald.de
Haring
Robin
R
Nauck
Matthias
M
Lüdemann
Jan
J
Rosskopf
Dieter
D
Spilcke-Liss
Elisabeth
E
Felix
Stephan B
SB
Dörr
Marcus
M
Brabant
Georg
G
Völzke
Henry
H
Wallaschofski
Henri
H
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000235:genetics / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood / Q000235:genetics*; D007334:Insulin-Like Growth Factor I / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009026:Mortality; D009369:Neoplasms / Q000235:genetics / Q000401:mortality; D016016:Proportional Hazards Models; D012959:Socioeconomic Factors; D055815:Young Adult
D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I