title: Effect of statin treatment on mortality in a large cohort of heart failure patients.
abstract: We studied 3162 heart failure patients included in the Spanish BADAPIC registry in order to determine whether statin treatment influences prognosis. Patients were followed up for 35 +/- 22 months (median, 32 months). Patients on statins were more often male and had higher prevalences of risk factors, ischemic heart disease and systolic dysfunction (P< .001) than those not on statins. After adjustment for age, risk factors, ischemic heart disease, renal failure, ejection fraction, anemia, heart rate and drug treatment, statin treatment was found to be a favorable independent predictor of survival: the hazard ratio for mortality was 0.73 (95% confidence interval, 0.45-0.88; P< .001). During follow-up, the 3-year survival rate was higher in patients treated with statins (75% vs. 68%; P< .001). In patients with heart failure, statin treatment appears to be independently associated with better survival.
authors.affiliation: Sección de Cardiología, Hospital General de Elche, Elche, 03007 Alicante, Spain. ajordant@coma.es
authors.forename: Alejandro J
authors.initials: AJ
authors.lastname: Jordán
authors.forename: Manuel P
authors.initials: MP
authors.lastname: Anguita
mesh_terms: D000368:Aged; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality*; D006334:Heart Function Tests; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology; D016019:Survival Analysis
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors