title: First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant.
abstract: The first total synthesis of the potent antioxidant antiostatin A1 is reported, where its key features rely on a chemo- and regioselective rhodium-catalysed crossed alkyne cyclotrimerisation reaction applying functionalised ynamides and a palladium-catalysed arylamidation reaction.
authors.affiliation: Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 6 Boulevard du Maréchal Juin, 14050, Caen, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Alayrac
authors.forename: Dieter
authors.initials: D
authors.lastname: Schollmeyer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Witulski
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000975:Antioxidants; D002227:Carbazoles; C540617:antiostatin A1; C041514:carbazole; D010165:Palladium; D012238:Rhodium