Drug resistance mutations for surveillance of transmitted HIV-1 drug-resistance: 2009 update.
Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately compare transmitted drug resistance rates across geographic regions and times, the World Health Organization has recommended the adoption of a consensus genotypic definition of transmitted HIV-1 drug resistance. In January 2007, we outlined criteria for developing a list of mutations for drug-resistance surveillance and compiled a list of 80 RT and protease mutations meeting these criteria (surveillance drug resistance mutations; SDRMs). Since January 2007, several new drugs have been approved and several new drug-resistance mutations have been identified. In this paper, we follow the same procedures described previously to develop an updated list of SDRMs that are likely to be useful for ongoing and future studies of transmitted drug resistance. The updated SDRM list has 93 mutations including 34 NRTI-resistance mutations at 15 RT positions, 19 NNRTI-resistance mutations at 10 RT positions, and 40 PI-resistance mutations at 18 protease positions.
Bennett
Diane E
DE
World Health Organization, Geneva, Switzerland.
Camacho
Ricardo J
RJ
Otelea
Dan
D
Kuritzkes
Daniel R
DR
Fleury
Hervé
H
Kiuchi
Mark
M
Heneine
Walid
W
Kantor
Rami
R
Jordan
Michael R
MR
Schapiro
Jonathan M
JM
Vandamme
Anne-Mieke
AM
Sandstrom
Paul
P
Boucher
Charles A B
CA
van de Vijver
David
D
Rhee
Soo-Yon
SY
Liu
Tommy F
TF
Pillay
Deenan
D
Shafer
Robert W
RW
D019380:Anti-HIV Agents / Q000494:pharmacology; D024882:Drug Resistance, Viral / Q000235:genetics*; D016333:HIV Protease / Q000235:genetics; D015497:HIV-1 / Q000737:chemistry / Q000235:genetics*; D009154:Mutation; D012194:RNA-Directed DNA Polymerase / Q000235:genetics; D014944:World Health Organization
D019380:Anti-HIV Agents; D012194:RNA-Directed DNA Polymerase; D016333:HIV Protease