title: Enantiorecognition of profens by capillary electrophoresis using a novel chiral selector eremomycin.
abstract: The evaluation of a macrocyclic glycopeptide antibiotic, eremomycin, as a chiral selector in capillary electrophoresis (CE) has been performed. The stability of eremomycin in solution and capillary electrolyte, as well as its optical and electrophoretic properties have been discussed. The effect of experimental parameters influencing the enantioseparation of several profens has been studied. Excellent enantioseparation of profens has been achieved and migration order has been validated. Comparison of enantioseparations of profens in CE by using eremomycin-mediated electrolytes and in HPLC with eremomycin immobilized on silica has revealed similar trends for both methods.
authors.affiliation: Chemistry Department, Division of Analytical Chemistry, Lomonosov Moscow State University, Leninskie Gory, Moscow, Russian Federation.
authors.forename: Aleksandra F
authors.initials: AF
authors.lastname: Prokhorova
authors.forename: Elena N
authors.initials: EN
authors.lastname: Shapovalova
authors.forename: Aleksei V
authors.initials: AV
authors.lastname: Shpak
authors.forename: Sergei M
authors.initials: SM
authors.lastname: Staroverov
authors.forename: Oleg A
authors.initials: OA
authors.lastname: Shpigun
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004573:Electrolytes / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D005480:Flurbiprofen / Q000032:analysis*; D006020:Glycopeptides / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010666:Phenylpropionates / Q000032:analysis*; D012680:Sensitivity and Specificity; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D004573:Electrolytes; D006020:Glycopeptides; D010666:Phenylpropionates; D012997:Solvents; C053759:eremomycin; D005480:Flurbiprofen