title: Arterial access-site-related outcomes of patients undergoing invasive coronary procedures for acute coronary syndromes (from the ComPaRison of Early Invasive and Conservative Treatment in Patients With Non-ST-ElevatiOn Acute Coronary Syndromes [PRESTO-ACS] Vascular Substudy).
abstract: Transradial access (TRA) decreased bleeding after coronary interventions compared with femoral access (FA). However, no large study focused on arterial access-related outcomes in patients with acute coronary syndromes, although procedure-related bleeding significantly impaired prognosis. The aim was to evaluate access site-related outcomes of patients who underwent an invasive coronary procedure in the PRESTO-ACS Study. The cumulative primary study end point was death or reinfarction during hospitalization and at 1-year follow-up. Secondary end points were in-hospital bleeding and a net clinical outcome (combination of the primary end point and bleeding). Of 1,170 patients studied, 863 underwent a percutaneous coronary procedure using FA, and 307, using TRA. Compared with FA, TRA was associated with higher glycoprotein IIb/IIIa inhibitor use (52% vs 34%; p <0.0001). The in-hospital primary end point was similar between TRA (2.6%) and FA (2.9%; p = 0.79). However, TRA was associated with a significant decrease in bleeding (0.7% vs 2.4%; p = 0.05) and a nonsignificant decrease in net clinical outcome (3.3% vs 4.6%; p = 0.30). At 1-year follow-up, the TRA group had a statistically significant decrease in death or reinfarction (4.9% vs 8.3%; p = 0.05), bleeding (0.7% vs 2.7%; p = 0.03), and net clinical outcome (5.5% vs 9.9%; p = 0.02). In conclusion, in patients with non-ST-elevation acute coronary syndromes, use of TRA was associated with lower bleeding complications and identified patients with better long-term outcomes.
authors.affiliation: Policlinico Casilino, ASL RMB, Rome, Italy. alessandro.sciahbasi@fastwebnet.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Sciahbasi
authors.forename: Christian
authors.initials: C
authors.lastname: Pristipino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ambrosio
authors.forename: Isabella
authors.initials: I
authors.lastname: Sperduti
authors.forename: Enrico Vittorio
authors.initials: EV
authors.lastname: Scabbia
authors.forename: Cesare
authors.initials: C
authors.lastname: Greco
authors.forename: Roberto
authors.initials: R
authors.lastname: Ricci
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ferraiolo
authors.forename: Domenico
authors.initials: D
authors.lastname: Di Clemente
authors.forename: Claudio
authors.initials: C
authors.lastname: Giombolini
authors.forename: Ernesto
authors.initials: E
authors.lastname: Lioy
authors.forename: Marco
authors.initials: M
authors.lastname: Tubaro
mesh_terms: D054058:Acute Coronary Syndrome / Q000628:therapy*; D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects* / Q000379:methods; D005260:Female; D005263:Femoral Artery; D006801:Humans; D008297:Male; D008875:Middle Aged; D019106:Postoperative Hemorrhage / Q000209:etiology*; D011677:Punctures / Q000009:adverse effects; D017534:Radial Artery; D016896:Treatment Outcome