title: Idiopathic infantile pyoderma gangrenosum with stridor responsive to infliximab.
abstract: A 4-month-old female infant presented with widespread pyoderma gangrenosum associated with stridor, presumed secondary to tracheal involvement. No underlying cause was revealed despite extensive investigation. Treatment with immunosuppressive agents only partially suppressed disease activity. Complete resolution followed treatment with infliximab. We review this rare condition in infants and discuss treatment with infliximab not previously described in this age group.
authors.affiliation: Department of Dermatology, The James Cook University Hospital, Middlesbrough, UK. drneilrajan@googlemail.com
authors.forename: Neil
authors.initials: N
authors.lastname: Rajan
authors.forename: Sharmila
authors.initials: S
authors.lastname: Das
authors.forename: Aileen
authors.initials: A
authors.lastname: Taylor
authors.forename: Mario
authors.initials: M
authors.lastname: Abinun
authors.forename: David
authors.initials: D
authors.lastname: Spencer
authors.forename: Andrew
authors.initials: A
authors.lastname: Carmichael
mesh_terms: D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001980:Bronchi / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D000069285:Infliximab; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D020545:Respiratory Mucosa / Q000473:pathology; D012135:Respiratory Sounds / Q000209:etiology*; D012867:Skin / Q000473:pathology; D014132:Trachea / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab