title: Wear resistance of artificial hip joints with poly(2-methacryloyloxyethyl phosphorylcholine) grafted polyethylene: comparisons with the effect of polyethylene cross-linking and ceramic femoral heads.
abstract: Aseptic loosening of artificial hip joints induced by wear particles from the polyethylene (PE) liner remains the ruinous problem limiting their longevity. We reported here that grafting with a polymer, poly(2-methacryloyloxyethyl phosphorylcholine (MPC)) (PMPC), on the PE liner surface dramatically decreased the wear production under a hip joint simulator condition. We examined that the effect of properties of both PE by cross-linking and femoral head by changing the materials on wearing properties of PE. The PMPC grafting on the liners increased hydrophilicity and decreased friction torque, regardless of the cross-linking of the PE liner or the difference in the femoral head materials. During the hip joint simulator experiments (5 x 10(6) cycles of loading), cross-linking caused a decrease of wear amount and a reduction of the particle size, while the femoral head materials did not affect it. The PMPC grafting abrogated the wear production, confirmed by almost no wear of the liner surface, independently of the liner cross-linking or the femoral head material. We concluded that the PMPC grafting on the PE liner surpasses the liner cross-linking or the change of femoral head materials for extending longevity of artificial hip joints.
authors.affiliation: Division of Science for Joint Reconstruction, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Moro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Ishihara
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kyomoto
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Karita
authors.forename: Hideya
authors.initials: H
authors.lastname: Ito
authors.forename: Kozo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Takatori
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002516:Ceramics / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D005270:Femur Head / Q000737:chemistry; D006622:Hip Prosthesis; D006801:Humans; D008422:Materials Testing; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D018613:Microscopy, Confocal; D008855:Microscopy, Electron, Scanning; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011095:Polyethylenes / Q000737:chemistry*; D011109:Polymethacrylic Acids
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D008689:Methacrylates; D011095:Polyethylenes; D011109:Polymethacrylic Acids; C115766:poly(2-methacryloyloxyethyl-phosphorylcholine); D010767:Phosphorylcholine; C070638:2-methacryloyloxyethyl phosphorylcholine