title: Morbidity and mortality in patients with cancer who become nonambulatory after spinal cord compression: a case series on end-of-life care.
abstract: BACKGROUND
  Few studies have focused on the outcomes of nonambulatory patients diagnosed with spinal cord compression from metastatic cancer. The purpose of this study was to review the morbidity and mortality suffered by these patients.
  
  
  METHODS
  Over a 10-year period (1996-2006), a retrospective review was undertaken to assess the outcomes of 39 nonambulatory patients diagnosed with spinal cord compression from metastatic cancer.
  
  
  RESULTS
  Treatment for cord compression included corticosteroids (n = 33), radiation (n = 25), and surgical decompression (n = 13). Nonetheless, 23 patients (59%) required bowel and/or bladder catheterization, and 33 (85%) required pain medications. Twenty-five (64%) did not regain ambulation. Only 13 patients (33%) went home without assistance. In contrast, 10 (26%) were transferred to a nursing home, 6 (15%) were sent home with hospice, 5 (13%) went home with home health care, and 1 (3%) was moved to a hospice inpatient facility. At the time of this report, all patients had died with a median survival of 76 days (range, 4-1975 days). Long-term survivors who lived beyond a year were primarily patients who had regained ambulation.
  
  
  CONCLUSIONS
  Metastatic cord compression causes severe morbidity and compromised survival in patients who become nonambulatory. Future palliative care efforts should focus on further characterizing and addressing these needs.
authors.affiliation: Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors.forename: Jocelin
authors.initials: J
authors.lastname: Huang
authors.forename: Aminah
authors.initials: A
authors.lastname: Jatoi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D010166:Palliative Care; D012189:Retrospective Studies; D013117:Spinal Cord Compression / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D013120:Spinal Cord Neoplasms / Q000150:complications* / Q000401:mortality / Q000556:secondary*; D016896:Treatment Outcome; D055815:Young Adult