A selective H4R antagonist prevents antigen-induced asthma-like reaction and airway inflammation in guinea pigs.
Masini
E
E
Departements of Preclinical and Clinical Pharmacology, Histology & Forensic Medicine, University of Florence, Viale Pieraccini, 6, 50139, Florence, Italy. emanuela.masini@unifi.it
Ragazzo
E
E
Vinci
M C
MC
Nistri
S
S
Cinci
L
L
Mastroianni
R
R
Thurmond
R L
RL
Salvemini
D
D
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001249:Asthma / Q000276:immunology*; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000517:prevention & control; D003371:Cough / Q000139:chemically induced / Q000276:immunology; D004417:Dyspnea / Q000139:chemically induced / Q000276:immunology; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000276:immunology / Q000517:prevention & control; D008297:Male; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors* / Q000276:immunology; D011968:Receptors, Histamine / Q000276:immunology; D000074040:Receptors, Histamine H4; D020545:Respiratory Mucosa / Q000187:drug effects / Q000276:immunology
D000941:Antigens; C418607:HRH4 protein, human; D006633:Histamine Antagonists; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D010047:Ovalbumin