title: [Preparation of floxuridine loaded polycation and its antitumor activity].
abstract: To develop a new prodrug of 5-fluorouracil-polyethylenimine-beta-cyclodextrin-floxuridine (PEI-beta-CyD-Fd) and to test its antitumor activity.
  
  
  
  Floxuridine was conjugated to polyethylenimine-beta-cyclodextrin to form prodrug PEI-beta-CyD-Fd. The structure of synthesized PEI-beta-CyD-Fd was confirmed by (1)H-NMR, FT-IR and UV. MTT assay and cell wound healing assay were performed on human hepatic carcinoma cell line HepG2.
  
  
  
  The drug loading was 2 %. The MTT assay and cell wound healing assay indicated that PEI-beta-CyD-Fd significantly inhibited proliferation and migration of HepG2 cells.
  
  
  
  The synthesized prodrug PEI-CyD-Fd has a significant antitumor activity on HepG2 cells.
authors.affiliation: Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou 310028, China.
authors.forename: Dan-Jun
authors.initials: DJ
authors.lastname: Zhao
authors.forename: Xiao
authors.initials: X
authors.lastname: Lu
authors.forename: Qi-Ying
authors.initials: QY
authors.lastname: Jiang
authors.forename: Dan
authors.initials: D
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Zhou
authors.forename: Hai
authors.initials: H
authors.lastname: Yu
authors.forename: Qing-Qing
authors.initials: QQ
authors.lastname: Wang
authors.forename: Gu-Ping
authors.initials: GP
authors.lastname: Tang
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D005467:Floxuridine / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D011094:Polyethyleneimine / Q000494:pharmacology*; D011355:Prodrugs / Q000138:chemical synthesis / Q000494:pharmacology; D047392:beta-Cyclodextrins / Q000494:pharmacology*
chemical_list: D000964:Antimetabolites, Antineoplastic; D011355:Prodrugs; D047392:beta-Cyclodextrins; D005467:Floxuridine; D011094:Polyethyleneimine; D005472:Fluorouracil