New 17-methyl-13-octadecenoic and 3,16-docosadienoic acids from the sponge Polymastia penicillus.
The phospholipid fatty acid composition of the North-East Atlantic sponge Polymastia penicillus (South Brittany, France) was investigated. Sixty fatty acids (FA) were identified as methyl esters (FAME) and N-acyl pyrrolidides (NAP) by gas chromatography-mass spectrometry (GC/MS), including eight Delta5,9 unsaturated FA and three long-chain 2-hydroxylated FA. The major phospholipid FA were palmitic (14.3% of the total FA mixture), vaccenic (12.7%), 15(Z)-docosenoic (13.4%) and 5(Z),9(Z)-hexacosadienoic (13.3%) acids. In addition to the iso- and anteiso-branched saturated FA, several unusual short-chain branched saturated FA were identified. In addition to the known Delta5,9 FA, and interestingly regarding their identification by GC-MS as N-acyl pyrrolidides, was the co-occurrence of unusual FA possessing a Delta3, Delta4 and Delta5 double bond such as iso-4-pentadecenoic, iso-5-heptadecenoic, anteiso-5-heptadecenoic and two new compounds, not hitherto found in nature, namely 17-methyl-13-octadecenoic (0.8%) and 3,16-docosadienoic (1.1%) acids.
Denis
Claire
C
Groupe MMS (Mer, Molécules, Santé) EA 2160, Equipe Lipides Marins, Faculté de Pharmacie, Pôle Mer et Littoral, Université de Nantes, 2 rue de La Houssinière, BP 92208, 44322 Nantes Cedex 03, France.
Wielgosz-Collin
Gaëtane
G
Bretéché
Anne
A
Ruiz
Nicolas
N
Rabesaotra
Vony
V
Boury-Esnault
Nicole
N
Kornprobst
Jean-Michel
JM
Barnathan
Gilles
G
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification*; D009829:Oleic Acids / Q000737:chemistry / Q000302:isolation & purification; D011161:Porifera / Q000737:chemistry* / Q000378:metabolism*
C543872:17-methyl-13-octadecenoic acid; D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids; C078401:13,16-docosadienoic acid