Autoimmune pancreatitis associated with high prevalence of gastric ulcer independent of Helicobacter pylori infection status.
OBJECTIVE
The relationship between Helicobacter pylori status and host tumor necrosis factor alpha (TNF-alpha) promoter susceptibility in ulcers inautoimmune pancreatitis (AIP) is unknown. We sought to study the frequency of peptic ulcer, the association of peptic ulcer with H. pylori and host TNF-alpha promoter haplotype in AIP and nonautoimmune chronic pancreatitis.


METHODS
Esophagogastroduodenoscopy (EGD) was performed in 40 patients with AIP and 113 patients with nonautoimmune chronic pancreatitis (CP). The status of H. pylori infection was determined. Genotyping and 5-locus haplotype assembly of the TNF-alpha promoter were performed. The correlation between clinical characteristics, endoscopic findings, Helicobacter pylori infection status, and TNF-alpha promoter polymorphism and haplotype was analyzed.


RESULTS
The frequencies of gastric ulcer (GU) was higher in patients with AIP compared with patients with nonautoimmune CP (22.5% vs 4.4%, P = 0.001). Duodenal ulcer (DU) was more prevalent than GU in both patients with AIP and patients with nonautoimmune CP. There was no difference in the positive status of H. pylori and TNF-alpha promoter polymorphism/haplotype.


CONCLUSIONS
Our results demonstrated that GU was more prevalent in AIP compared with nonautoimmune CP. Positive H. pylori status and host TNF-alpha promoter susceptibility could not explain the pathogenesis of higher GU prevalence and pathogenesis of AIP in our population.
Chang
Ming-Chu
MC
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Chang
Yu-Ting
YT
Wei
Shu-Chen
SC
Kuo
Chun-Hung
CH
Liang
Po-Chin
PC
Wong
Jau-Min
JM
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D001483:Base Sequence; D004381:Duodenal Ulcer / Q000150:complications / Q000175:diagnosis / Q000235:genetics; D016145:Endoscopy, Digestive System; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis*; D016480:Helicobacter pylori / Q000502:physiology; D054884:Host-Pathogen Interactions; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D010195:Pancreatitis / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics; D013276:Stomach Ulcer / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D007074:Immunoglobulin G; D014409:Tumor Necrosis Factor-alpha