title: Cardiopulmonary manifestations of hepatosplenic schistosomiasis.
abstract: BACKGROUND
  Schistosomiasis is a highly prevalent disease with >200 million infected people. Pulmonary hypertension is one of the pulmonary manifestations in this disease, particularly in its hepatosplenic presentation. The aim of this study was to determine the prevalence of pulmonary hypertension in schistosomiasis patients with the hepatosplenic form of the disease.
  
  
  RESULTS
  All patients with hepatosplenic schistosomiasis followed up at the gastroenterology department of our university hospital underwent echocardiographic evaluation to search for pulmonary hypertension. Patients presenting with systolic pulmonary artery pressure >40 mm Hg were further evaluated through right heart catheterization. Our study showed an 18.5% prevalence of patients with elevated systolic pulmonary artery pressure at echocardiography. Invasive hemodynamics confirmed the presence of pulmonary hypertension in 7.7% (95% confidence interval, 3.3 to 16.7) of patients, with a prevalence of precapillary (arterial) pulmonary hypertension of 4.6% (95% confidence interval, 1.5 to 12.7).
  
  
  CONCLUSIONS
  Our study reinforces the role of echocardiography as a screening tool in the investigation of pulmonary hypertension, together with the need for invasive monitoring for a proper diagnosis. We conclude that hepatosplenic schistosomiasis may account for one of the most prevalent forms of pulmonary hypertension worldwide, justifying the development of further studies to evaluate the effect of specific pulmonary hypertension treatment in this particular form of the disease.
authors.affiliation: Pulmonary Hypertension Group, Pulmonary Department, Heart Institute, University of Sao Paulo Medical School, Sao Paulo, Brazil.
authors.forename: Monica
authors.initials: M
authors.lastname: Lapa
authors.forename: Bruno
authors.initials: B
authors.lastname: Dias
authors.forename: Carlos
authors.initials: C
authors.lastname: Jardim
authors.forename: Caio J C
authors.initials: CJ
authors.lastname: Fernandes
authors.forename: Paulo M M
authors.initials: PM
authors.lastname: Dourado
authors.forename: Magda
authors.initials: M
authors.lastname: Figueiredo
authors.forename: Alberto
authors.initials: A
authors.lastname: Farias
authors.forename: Jeane
authors.initials: J
authors.lastname: Tsutsui
authors.forename: Mario
authors.initials: M
authors.lastname: Terra-Filho
authors.forename: Marc
authors.initials: M
authors.lastname: Humbert
authors.forename: Rogerio
authors.initials: R
authors.lastname: Souza
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization; D004452:Echocardiography; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000469:parasitology*; D008109:Liver Diseases, Parasitic / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011669:Pulmonary Wedge Pressure; D012555:Schistosomiasis mansoni / Q000453:epidemiology*; D013158:Splenic Diseases / Q000453:epidemiology* / Q000469:parasitology*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000469:parasitology