title: Prokaryotic and eukaryotic integral membrane proteins have similar architecture.
abstract: Integral membrane proteins constitute a major constituent of lipid bilayer both in prokaryotes and eukaryotes. The statistical analysis was carried out to determine the bias in amino acid distribution between prokaryotic and eukaryotic integral membrane proteins (pIntMPs and eIntMPs). Our results indicate that both pIntMPs and eIntMPs demonstrate the striking similarity in amino acid distribution in their transmembrane and extramembranous region. pIntMPs have relatively greater functional importance for Gly and Asn in comparison to eIntMPs.
authors.affiliation: Redox Biology Center, N118 Beadle Center, University of Nebraska, Lincoln, NE 68588-0662, USA. meetgaur@gmail.com
authors.forename: Rajneesh Kumar
authors.initials: RK
authors.lastname: Gaur
authors.forename: Girija Arun
authors.initials: GA
authors.lastname: Natekar
mesh_terms: D000596:Amino Acids / Q000032:analysis*; D005057:Eukaryotic Cells / Q000737:chemistry*; D008565:Membrane Proteins / Q000235:genetics*; D011387:Prokaryotic Cells / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D008565:Membrane Proteins