Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice.
OBJECTIVE
Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT(3) receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol).


METHODS
The present study was designed to explore the effect of 3 serotonin 5-HT(3) receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests.


RESULTS
Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test.


CONCLUSIONS
These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.
Girard
Philippe
P
Biocodex, Service de Pharmacologie, Compiègne, France.
Pansart
Yannick
Y
Coppé
Marie-Claude
MC
Niedergang
Betty
B
Gillardin
Jean-Marie
JM
D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology; D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009340:Nefopam / Q000008:administration & dosage / Q000494:pharmacology*; D017294:Ondansetron / Q000008:administration & dosage / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000077526:Tropisetron
D000700:Analgesics; D007211:Indoles; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists; D000082:Acetaminophen; D017294:Ondansetron; D009340:Nefopam; D000077526:Tropisetron; D019342:Acetic Acid