title: Maternal thrombocytopenia-absent radius syndrome complicated by severe pre-eclampsia.
abstract: Thrombocytopenia-absent radius (TAR) syndrome affects 0.5-1/100,000 live births. We describe, to the best of our knowledge, the sixth patient with TAR to experience a successful pregnancy and the first such case complicated by severe pre-eclampsia. The diagnosis of pre-eclampsia was made at 33 weeks by blood pressure and proteinuria. A further decline in platelets suggested, but could not reliably confirm, severe pre-eclampsia until she experienced persistently elevated aspartate aminotransferase levels. Repeat cesarean delivery was performed at 33 4/7 weeks' gestation. Obstetrical conditions characterised by thrombocytopenia may present diagnostic challenges and should be considered in the differential diagnosis of thrombocytopenic exacerbations in TAR syndrome.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Maine Medical Center, Portland, Maine, USA. waxj@mmc.org
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Wax
authors.forename: Chelsea
authors.initials: C
authors.lastname: Crabtree
authors.forename: Jacquelyn
authors.initials: J
authors.lastname: Blackstone
authors.forename: Michael G
authors.initials: MG
authors.lastname: Pinette
authors.forename: Angelina
authors.initials: A
authors.lastname: Cartin
mesh_terms: D000328:Adult; D001219:Aspartate Aminotransferases / Q000032:analysis; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D017713:Platelet Transfusion; D011225:Pre-Eclampsia; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D011884:Radius / Q000002:abnormalities*; D012720:Severity of Illness Index; D013921:Thrombocytopenia / Q000150:complications*
chemical_list: D001219:Aspartate Aminotransferases