title: Ocular granulomatous meningoencephalomyelitis in a dog: magnetic resonance images and clinical findings.
abstract: A 4-year-old female miniature dachshund presented with a history of progressive decrease in vision, neck pain, and ataxia for which an MRI was performed 21 days after the initial consultation. The optic nerves showed isointensities on T1- (T1W) and T2-weighted (T2W) images that were enhanced by the contrast medium. The optic chiasm was swollen. Other parts of the cerebral parenchyma, not only the visual pathway, showed symmetrical hyperintensities on T2W images. Cerebrospinal fluid showed increased anti-GFAP autoantibodies. The dog received corticosteroid therapy despite which she exhibited anorexia, vomiting, and lethargy. Hence, a follow-up MRI was repeated 30 days after the initial consultation in which T2W images showed enlargement of the hyperintense area. The dog died 45 days after the initial consultation. Postmortem pathological examination confirmed a diagnosis of granulomatous meningoencephalomyelitis (GME).
authors.affiliation: Laboratory Comprehensive Veterinary Clinical Studies, Nihon University School of Veterinary Medicine, Fujisawa, Kanagawa, Japan. kitagawa@brs.nihon-u.ac.jp
authors.forename: Masato
authors.initials: M
authors.lastname: Kitagawa
authors.forename: Midori
authors.initials: M
authors.lastname: Okada
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Watari
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Sato
authors.forename: Kiichi
authors.initials: K
authors.lastname: Kanayama
authors.forename: Takeo
authors.initials: T
authors.lastname: Sakai
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D004679:Encephalomyelitis / Q000473:pathology / Q000662:veterinary*; D005123:Eye / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000473:pathology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008590:Meningoencephalitis / Q000473:pathology / Q000662:veterinary*