[Bullous keratopathy: etiopathogenesis and treatment].
Bullous keratopathy is characterized by corneal stromal edema with epithelial or subepithelial bullae due to cell loss and endothelial decompensation. In more advanced cases, subepithelial fibrosis, formation of a posterior collagenous layer or retrocorneal fibrous membrane, and corneal vascularization can occur. Decreased vision is present because the loss of corneal transparency with symptoms like tearing and pain caused by epithelial bullae that can rupture. Currently, bullous keratopathy is the most common indication for penetrating keratoplasty and regraft. The main etiology is the endothelial cell loss after ophthalmic surgeries as cataract surgery. Cataract affects approximately 20 million people worldwide, and this complication can occur in 1 to 2% of cataract surgeries. This study revised bullous keratopathy etiopathogenesis, clinical and surgical treatment available for this corneal disease.
Gonçalves
Eliana Domingues
ED
Departamento de Oftalmologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil. elianadgoncalves@terra.com.br
Campos
Mauro
M
Paris
Fabiana
F
Gomes
José Alvaro Pereira
JA
Farias
Charles Costa de
CC
D001768:Blister / Q000209:etiology / Q000628:therapy; D002387:Cataract Extraction / Q000009:adverse effects; D015715:Corneal Edema / Q000209:etiology / Q000628:therapy; D016039:Corneal Transplantation; D006801:Humans