title: The potential of RF backscattered IVUS data and multidetector-row computed tomography images for tissue characterization of human coronary atherosclerotic plaques.
abstract: The aim is to compare virtual histology which uses spectral analysis of backscattered intravascular ultrasound (VH-IVUS) and multidetector-row computed tomography (MDCT) for the characterization of coronary atherosclerotic plaques obtained by directional coronary atherectomy (DCA). We performed DCA in 15 de novo native coronary stenotic lesions (15 patients) and selected one or two segments within the plaque from each patient (total 29 segments). Then, we evaluated the accuracy of the VH-IVUS findings in 50 sites among the 29 segments compared with the histopathology findings. MDCT was performed in all patients before percutaneous coronary intervention (PCI), and CT density values were measured. VH-IVUS data analysis correlated well with histopathological examination (predictive accuracy: 66.7% for fibrous, 100% for fibro-fatty, 100% for necrotic core, and 100% for dense calcium regions, respectively). In addition, CT density values between fibrous and fibro-fatty plaques classified by histopathology were 100.0 +/- 26.0 HU versus 110.4 +/- 67.9 HU, there were no difference among them (P = 0.594). These findings indicated that the validation of plaque characteristics using VH-IVUS correlates well with histopathology. While tissue characterization using CT density could be difficult to distinguish between fibro-fatty and fibrous tissue.
authors.affiliation: Department of Cardiology, The Cardiovascular Institute, 7-3-10 Roppongi Minato-ku, Tokyo, Japan. funapon@mui.biglobe.ne.jp
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Funada
authors.forename: Yuji
authors.initials: Y
authors.lastname: Oikawa
authors.forename: Junji
authors.initials: J
authors.lastname: Yajima
authors.forename: Hajime
authors.initials: H
authors.lastname: Kirigaya
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Nagashima
authors.forename: Ken
authors.initials: K
authors.lastname: Ogasawara
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Matsuno
authors.forename: Toshiro
authors.initials: T
authors.lastname: Inaba
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: Michinari
authors.initials: M
authors.lastname: Nakamura
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kurabayashi
authors.forename: Tadanori
authors.initials: T
authors.lastname: Aizawa
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017225:Atherectomy, Coronary; D002114:Calcinosis / Q000000981:diagnostic imaging; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D005260:Female; D005355:Fibrosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed; D018084:Ultrasonography, Interventional; D014584:User-Computer Interface