Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines.
A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.
Nakanishi
Jun
J
World Premier International Research Center Initiative, International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. nakanishi.jun@nims.go.jp
Nakayama
Hidekazu
H
Shimizu
Takahiro
T
Ishida
Haruhisa
H
Kikuchi
Yukiko
Y
Yamaguchi
Kazuo
K
Horiike
Yasuhiro
Y
D000588:Amines / Q000737:chemistry*; D006046:Gold; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D012107:Research Design; D015398:Signal Transduction / Q000528:radiation effects*
D000588:Amines; D006046:Gold