Evaluation of potassium permanganate against an experimental subacute infection of Flavobacterium columnare in channel catfish, Ictalurus punctatus (Rafinesque).
An experiment was performed to evaluate the efficacy of potassium permanganate (KMnO4) as a prophylactic and therapeutic treatment of an experimental subacute infection of Flavobacterium columnare in channel catfish, Ictalurus punctatus. Fish were cutaneously abraded and divided into five treatment groups: (i) challenged by waterborne exposure to F. columnare and not treated with KMnO4 (positive control), (ii) challenged and simultaneously treated with KMnO4, (iii) challenged and treated with KMnO4 at 1, 6 and 9 days post-challenge, (iv) not challenged and treated with KMnO4 at 1, 6 and 9 days post-challenge (first negative control) and (v) not challenged and not treated (second negative control). The dosing of KMnO4 was 2.0 mg L(-1) above the potassium permanganate demand for 2 h duration. The survival of the group challenged and simultaneously treated with KMnO4 (99%) was significantly higher than the positive control (78%) and was not significantly different from the negative control groups. The challenged fish treated with KMnO4 post-challenge had 7% higher survival than the positive control (85% compared with 78%), but that difference was not statistically significant. The results demonstrate that KMnO4 has a clear prophylactic value but probably a marginal therapeutic value once the infection has established.
Darwish
A M
AM
Harry K. Dupree-Stuttgart National Aquaculture Research Center, Agricultural Research Service, United States Department of Agriculture, Stuttgart, Arkansas, USA. ahmed.darwish@ars.usda.gov
Mitchell
A J
AJ
Straus
D L
DL
D000818:Animals; D005393:Fish Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control; D045826:Flavobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D005417:Flavobacterium / Q000187:drug effects / Q000502:physiology*; D007059:Ictaluridae / Q000382:microbiology*; D011196:Potassium Permanganate / Q000627:therapeutic use*; D011897:Random Allocation; D016019:Survival Analysis
D011196:Potassium Permanganate