Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature.
BACKGROUND
Carcinosarcomas of the uterine cervix are very rare. Most of them have a homologous mesenchymal component, and cervical carcinosarcomas with a heterologous mesenchymal component are limited to nine cases.


METHODS
A 61-year-old Japanese woman was admitted to the hospital for treatment of a ureteral stone. Imaging studies detected an indistinct cervical mass. A histopathological diagnosis of the cervical biopsy was a carcinosarcoma. A total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was carried out upon a diagnosis of stage Ib1 cervical carcinosarcoma. Microscopically, the cervical mass revealed a carcinosarcoma consisting of endometrioid adenocarcinoma and chondrosarcoma. Immunohistochemically, p53 was positive in the epithelial and mesenchymal components. Postoperatively, the patient underwent radiation and chemotherapy. She is alive with no evidence of recurrence 5 years and 10 months after the operation.


CONCLUSIONS
We suppose that the similar proportion of p53 overexpression in both the epithelial and mesenchymal components may be one of the findings explaining the histogenesis of this tumor by combination theory.
Kadota
Kyuichi
K
Department of Diagnostic Pathology, Faculty of Medicine, University Hospital, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kagawa 761-0793, Japan. qichi@med.kagawa-u.ac.jp
Haba
Reiji
R
Ishikawa
Masashi
M
Kushida
Yoshio
Y
Katsuki
Naomi
N
Hayashi
Toshitetsu
T
Miyai
Yumi
Y
Bando
Kenji
K
Shiota
Atsuko
A
Hata
Toshiyuki
T
D001706:Biopsy; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*