title: Contribution of the vertebral posterior elements in anterior-posterior DXA spine scans in young subjects.
abstract: Because DXA is a projection technique, anterior-posterior (AP) measurements of the spine include the posterior elements and the vertebral body. This may be a disadvantage because the posterior elements likely contribute little to vertebral fracture resistance. This study used QCT to quantify the impact of the posterior elements in DXA AP spine measures. We examined 574 subjects (294 females and 280 males), age 6-25 yr, with DXA and QCT. QCT measures were calculated for the cancellous bone region and for the vertebral body including and excluding the posterior elements. DXA data were analyzed for the entire L(3) vertebra and for a 10-mm slice corresponding to the QCT scan region. BMC and BMD were determined and compared using Pearson's correlation. The posterior elements accounted for 51.4 +/- 4.2% of the total BMC, with a significant difference between males (49.9 +/- 4.0%) and females (52.8 +/- 3.9%, p < 0.001). This percentage increased with age in younger subjects of both sexes (p < 0.001) but was relatively consistent after age 17 for males and 16 for females (p > 0.10). DXA areal BMD and QCT volumetric BMD correlated strongly for the whole vertebra including the posterior elements (R = 0.83), with BMC measures showing a stronger relationship (R = 0.93). Relationships were weaker when excluding the posterior elements. We conclude that DXA BMC provides a measure of bone that is most consistent with QCT and that the contribution of the posterior elements is consistent in young subjects after sexual maturity.
authors.affiliation: Orthopaedic Center, Childrens Hospital, Los Angeles, California, USA. davidcle@usc.edu
authors.forename: David C
authors.initials: DC
authors.lastname: Lee
authors.forename: Patricia P
authors.initials: PP
authors.lastname: Campbell
authors.forename: Vicente
authors.initials: V
authors.lastname: Gilsanz
authors.forename: Tishya Al
authors.initials: TA
authors.lastname: Wren
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D015519:Bone Density; D002648:Child; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae; D008297:Male; D013131:Spine / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D055815:Young Adult