title: Embryonal neural tumours and cell death.
abstract: Medulloblastoma and neuroblastoma are malignant embryonal childhood tumours of the central and peripheral nervous systems, respectively, which often show poor clinical prognosis due to resistance to current chemotherapy. Both these tumours have deficient apoptotic machineries adopted from their respective progenitor cells. This review focuses on the specific background for tumour development, and highlights biological pathways that present potential targets for novel therapeutic approaches.
authors.affiliation: Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Childhood Cancer Research Unit, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: John Inge
authors.initials: JI
authors.lastname: Johnsen
authors.forename: Per
authors.initials: P
authors.lastname: Kogner
authors.forename: Ami
authors.initials: A
authors.lastname: Albihn
authors.forename: Marie Arsenian
authors.initials: MA
authors.lastname: Henriksson
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D016543:Central Nervous System Neoplasms / Q000196:embryology / Q000378:metabolism / Q000628:therapy*; D002648:Child; D006801:Humans; D008527:Medulloblastoma / Q000378:metabolism / Q000628:therapy; D008954:Models, Biological; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism / Q000628:therapy*; D009447:Neuroblastoma / Q000378:metabolism / Q000628:therapy