When you are Dishevelled, fat is good and acid is bad!
Frizzled receptors regulate cell fate decisions and planar cell polarity by means of distinct intracellular effectors. The choice between these two signalling outputs may involve a pH-dependent interaction between Dishevelled and negatively charged lipids at the plasma membrane.
Schweisguth
François
F
Institut Pasteur, CNRS URA2578, 25 rue du Dr Roux, 75015 Paris, France. francois.schweisguth@pasteur.fr
D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology* / Q000378:metabolism*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D051157:Frizzled Receptors / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D010743:Phospholipids / Q000378:metabolism*; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D010743:Phospholipids; D010750:Phosphoproteins; C000606588:dsh protein, Drosophila