title: Histologic features of mesotherapy-induced orbital fat inflammation.
abstract: A 67-year-old man developed acute orbital inflammation after receiving cosmetic mesotherapy (Lipo-Dissolve) to the inferior orbital fat compartments. The injection was intended to cause lipolysis and shrinkage of fat lobules with subsequent cosmetic improvement. Injections of a mixture of bile salts, phospholipid, and alcohol preservative bilaterally in inferior orbital fat lobules led to an acute inflammatory reaction characterized histologically 12 days later by mild lymphocytic infiltration, fat necrosis, and fibrosis in the target areas. Benign proliferation of peripheral nerve trunks consistent with a traumatic neuroma was also noted histologically on one side. Inflammation including fat necrosis and traumatic neuroma are all possible consequences of mesotherapy.
authors.affiliation: Department of Ophthalmology, University of California, Irvine, California 92697-4375, USA. cnabavi@uci.edu
authors.forename: Cameron B
authors.initials: CB
authors.lastname: Nabavi
authors.forename: Donald S
authors.initials: DS
authors.lastname: Minckler
authors.forename: Jeremiah P
authors.initials: JP
authors.lastname: Tao
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects*; D000368:Aged; D003357:Cosmetic Techniques / Q000009:adverse effects*; D005218:Fat Necrosis / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D006801:Humans; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D009915:Orbit / Q000187:drug effects*; D054517:Orbital Cellulitis / Q000139:chemically induced* / Q000473:pathology* / Q000601:surgery; D010713:Phosphatidylcholines / Q000009:adverse effects*
chemical_list: D010713:Phosphatidylcholines; C005152:lipostabil