title: Cooperative production of siderophores by Pseudomonas aeruginosa.
abstract: The production of iron-scavenging siderophores by the opportunistic animal pathogen Pseudomonas aeruginosa is a textbook example of public goods cooperation. This trait provides an excellent model system with which to study cooperation. Further, the links between siderophore production and P. aeruginosa virulence allow us to investigate how pathogen ecology, social behaviour and pathology might be connected. We present here the results of basic research on the evolution and ecology of siderophore cooperation in this species. In particular, we explore the effects of population and community structure, iron regime and genomic mutation rate on the relative success of siderophore cooperators and cheats. We also present preliminary data on the links between siderophore production and another clinically-relevant social trait, biofilm formation. It is our hope that more realistic laboratory studies of siderophore cooperation in P. aeruginosa will eventually cast light on the roles played by social traits in long-term microbial infections.
authors.affiliation: Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS UK. freya.harrison@zoo.ox.ac.uk
authors.forename: Freya
authors.initials: F
authors.lastname: Harrison
authors.forename: Angus
authors.initials: A
authors.lastname: Buckling
mesh_terms: D011550:Pseudomonas aeruginosa / Q000378:metabolism* / Q000472:pathogenicity; D017262:Siderophores / Q000096:biosynthesis*; D014774:Virulence
chemical_list: D017262:Siderophores