title: Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel.
abstract: The aim of the present work is the modification of a hydrophobic polymeric macromolecule, polymethylmethacrylate, by introducing hydrophilic moieties of 2-hydroxyethyl methacrylate within the polymer chain. Synthesis, characterization, and drug delivery control capabilities exerted on a highly hydrophobic drug (Paclitaxel) are illustrated. In particular, the dependency of the drug delivery kinetic on the fraction of hydrophilic units inserted in the copolymer chain was studied. Results showed that it is possible to have an increase of the kinetic delivery introducing hydrophilic units. In addition, a double control, diffusive and due to the relaxation of the molecules, on drug delivery was obtained.
authors.affiliation: Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Pisa, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Silvestri
authors.forename: Mariacristina
authors.initials: M
authors.lastname: Gagliardi
authors.forename: Niccoletta
authors.initials: N
authors.lastname: Barbani
authors.forename: Caterina
authors.initials: C
authors.lastname: Cristallini
authors.forename: Paolo
authors.initials: P
authors.lastname: Giusti
mesh_terms: D000465:Algorithms; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D020366:Methylmethacrylate / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis; D013818:Thermogravimetry; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D008689:Methacrylates; D011108:Polymers; D014867:Water; D020366:Methylmethacrylate; C005044:hydroxyethyl methacrylate; D017239:Paclitaxel