title: Protein-protein interactions and gene expression regulation in HTLV-1 infected cells.
abstract: Human T-cell leukemia virus type 1 (HTLV-1) propagates in CD4 or CD8 T cells and, after extended latency periods of 30-50 years, causes a rapidly fatal leukemia called adult T-cell leukemia/lymphoma (ATL). Infection with HTLV-1 is also associated with a degenerative neuromuscular disease referred to as tropical spastic paraparesis or HTLV-1-associated myelopathy. HTLV genome, in addition to the structural proteins and retroviral enzymes, codes for a region at its 3' end originally designated pX. The products of this region (Tax, Rex, p12I, p13II, p30II and HBZ) play important roles in deregulation of cellular functions by either directly disrupting cellular factors or altering transcription of viral and cellular genes. Here, we will review current knowledge of protein-protein interactions that regulate transcriptional functions of proteins encoded by the pX region.
authors.affiliation: Cellular and Molecular Biology Unit, FUSAGx, 5030 Gembloux, Belgium.
authors.forename: Sebastien
authors.initials: S
authors.lastname: Legros
authors.forename: Mathieu
authors.initials: M
authors.lastname: Boxus
authors.forename: Jean Francois
authors.initials: JF
authors.lastname: Dewulf
authors.forename: Franck
authors.initials: F
authors.lastname: Dequiedt
authors.forename: Richard
authors.initials: R
authors.lastname: Kettmann
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Twizere
mesh_terms: D015967:Gene Expression Regulation, Viral; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011485:Protein Binding; D014764:Viral Proteins / Q000378:metabolism*
chemical_list: D014764:Viral Proteins