[Characteristic effects of L-lysine-alpha-oxidase, an antitumor enzyme produced by Trichoderma sp].
Acute toxicity of L-lysine-alpha-oxidase, an antitumor enzyme of fungal origin was studied. After intravenous administration in a dose of 3000 U/kg the substance induced no signs of intoxication in the laboratory animals or their death. Direct dependence of the vessel permeability increase on the enzyme concentration was determined. In experiments on rabbits and guinea pigs L-lysine-alpha-oxidase showed no local irritating effect.
Alekseev
S B
SB
Smirnova
I P
IP
D000594:Amino Acid Oxidoreductases / Q000633:toxicity*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D002199:Capillary Permeability / Q000187:drug effects; D006168:Guinea Pigs; D007928:Lethal Dose 50; D051379:Mice; D011817:Rabbits; D011896:Rana temporaria; D051381:Rats; D023422:Skin Irritancy Tests; D036401:Toxicity Tests, Chronic; D014242:Trichoderma / Q000201:enzymology*
D000903:Antibiotics, Antineoplastic; D000594:Amino Acid Oxidoreductases; C041123:L-lysine oxidase