title: Glucometabolic state of in-hospital primary hypertension patients with normal fasting blood glucose in a sub-population of China.
abstract: BACKGROUND
  There is a high prevalence of abnormal glucometabolism (AGM) in patients with coronary heart disease (CHD) and primary hypertension (PH). However, little is known about the glucometabolic state of PH patients with normal fasting blood glucose (FBG).
  
  
  METHODS
  Oral glucose tolerance test (OGTT) was performed for 445 in-hospital PH patients with normal FBG and re-performed for those patients with impaired glucose tolerance (IGT) during the follow-up period.
  
  
  RESULTS
  Diabetes mellitus (DM), IGT, and AGM (including IGT and DM) accounted for 4.4, 24.5, and 28.9% of patients, respectively. Prevalence of AGM in patients with higher haemoglobin A(1c) (HbA(1c)) (> or =6.0%), risk factors (CHD, overweight, hyperlipidaemia, proteinuria) was significantly higher than that in patients without these factors. Regression analysis showed that age, overweight, proteinuria, HbA(1c), and CRP were the independent risk factors of AGM. Follow-up data in 98 IGT patients showed that no improvement of glucometabolism was found, but contrarily, a significant increase of new onset of impaired fasting glucose (IFG) and DM was found after 9 months (P < 0.05), even if diet control and moderate exercise were adopted.
  
  
  CONCLUSIONS
  AGM is prevalent and underestimated in PH patients with normal FBG, and it will develop even if therapeutic life-style changes are adopted. Except for FBG, more attention should be paid to postprandial blood glucose. OGTT should be a routine procedure for PH patients, especially in-hospital PH patients, regardless of normal FBG, and active drug intervention for IGT patients with PH may be recommended.
authors.affiliation: Department of Cardiology, Sun Yat-sen Memorial Hospital of Sun Yat-sen University, Guangzhou 510120, Guangdong, China.
authors.forename: Yang-Xin
authors.initials: YX
authors.lastname: Chen
authors.forename: Chong-Feng
authors.initials: CF
authors.lastname: Fang
authors.forename: XiaoQiao
authors.initials: X
authors.lastname: Wang
authors.forename: Ru-Qiong
authors.initials: RQ
authors.lastname: Nie
authors.forename: GuoQi
authors.initials: G
authors.lastname: Li
authors.forename: LiJiang
authors.initials: L
authors.lastname: Tang
authors.forename: Shu-Xian
authors.initials: SX
authors.lastname: Zhou
authors.forename: Jing-Feng
authors.initials: JF
authors.lastname: Wang
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting / Q000097:blood*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000378:metabolism; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance
chemical_list: D001786:Blood Glucose