title: Animal models of smoke inhalation induced injuries.
abstract: Smoke inhalation injury is the leading cause of mortality from structural fires, as a result of complications such as systemic inflammatory response syndrome and chronic obstructive pulmonary disease, which can be caused by a localized or systemic response. In this review, the pathophysiology of smoke inhalation injury, along with the characteristics found in clinical settings, common animal models, current treatment methods and future potential therapeutics are discussed.
authors.affiliation: Combat Care Laboratory, Combat Care and Performance Programme, Defence Medical and Environmental Research Institute, DSO National Laboratories (Kent Ridge), 27 Medical Drive 09-01, Singapore 117510.
authors.forename: Poon
authors.initials: P
authors.lastname: David
authors.forename: Denny
authors.initials: D
authors.lastname: Dunsford
authors.forename: Jia
authors.initials: J
authors.lastname: Lu
authors.forename: Shabbir
authors.initials: S
authors.lastname: Moochhala
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D019570:Inhalation Exposure; D012137:Respiratory System / Q000293:injuries*; D012906:Smoke / Q000009:adverse effects*
chemical_list: D012906:Smoke