Idiopathic infantile pyoderma gangrenosum with stridor responsive to infliximab.
A 4-month-old female infant presented with widespread pyoderma gangrenosum associated with stridor, presumed secondary to tracheal involvement. No underlying cause was revealed despite extensive investigation. Treatment with immunosuppressive agents only partially suppressed disease activity. Complete resolution followed treatment with infliximab. We review this rare condition in infants and discuss treatment with infliximab not previously described in this age group.
Rajan
Neil
N
Department of Dermatology, The James Cook University Hospital, Middlesbrough, UK. drneilrajan@googlemail.com
Das
Sharmila
S
Taylor
Aileen
A
Abinun
Mario
M
Spencer
David
D
Carmichael
Andrew
A
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D001980:Bronchi / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D000069285:Infliximab; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D020545:Respiratory Mucosa / Q000473:pathology; D012135:Respiratory Sounds / Q000209:etiology*; D012867:Skin / Q000473:pathology; D014132:Trachea / Q000473:pathology
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab