The abbreviated impactor measurement (AIM) concept: part 1--Influence of particle bounce and re-entrainment-evaluation with a "dry" pressurized metered dose inhaler (pMDI)-based formulation.
The abbreviated impactor measurement concept is a potential improvement to the labor-intensive full-resolution cascade impactor methodology for inhaler aerosol aerodynamic particle size distribution (APSD) measurement by virtue of being simpler and therefore quicker to execute. At the same time, improved measurement precision should be possible by eliminating stages upon which little or no drug mass is collected. Although several designs of abbreviated impactor systems have been developed in recent years, experimental work is lacking to validate the technique with aerosols produced by currently available inhalers. In part 1 of this two-part article that focuses on aerosols produced by pressurized metered dose inhalers (pMDIs), the evaluation of two abbreviated impactor systems (Copley fast screening Andersen impactor and Trudell fast screening Andersen impactor), based on the full-resolution eight-stage Andersen nonviable cascade impactor (ACI) operating principle, is reported with a formulation producing dry particles. The purpose was to investigate the potential for non-ideal collection behavior associated with particle bounce in relation to internal losses to surfaces from which particles containing active pharmaceutical ingredient are not normally recovered. Both abbreviated impactors were found to be substantially equivalent to the full-resolution ACI in terms of extra-fine and fine particle and coarse mass fractions used as metrics to characterize the APSD of these pMDI-produced aerosols when sampled at 28.3 L/min, provided that precautions are taken to coat collection plates to minimize bounce and entrainment.
Mitchell
J P
JP
Trudell Medical International, 725 Third Street, London, Ontario, Canada. jmitchell@trudellmed.com
Nagel
M W
MW
Avvakoumova
V
V
MacKay
H
H
Ali
R
R
D000280:Administration, Inhalation; D000336:Aerosols; D004867:Equipment Design; D008422:Materials Testing / Q000295:instrumentation*; D036501:Metered Dose Inhalers; D010316:Particle Size; D011312:Pressure; D015203:Reproducibility of Results; D019141:Respiratory System Agents / Q000008:administration & dosage / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000295:instrumentation*
D000336:Aerosols; D019141:Respiratory System Agents