title: [Protective effects of Huanglian-Jiedu-Tang on chronic brain injury after focal cerebral ischemia in mice].
abstract: To investigate the neuroprotective effects of Chinese herb medicine Huanglian-Jiedu-Tang (HJDT) on chronic brain injury after focal cerebral ischemia in mice.
  
  
  
  Focal cerebral ischemia was induced by occlusion of right middle cerebral artery (MCA) for 15 min. HJDT (at dosage of 2 g/kg or 4 g/kg, qd, orally) was administered for 21 d from d 7 before ischemia until d 14 after ischemia. The sham and ischemic controls were administered with normal saline orally. The neurological deficit scoring and the inclined board testing were performed within 35 d after ischemia. The survival rate, the infarct volume and the neuron density were assessed 35 d after ischemia.
  
  
  
  HJDT increased the survival rate at dose of 4 g/kg; significantly reduced the neurological deficits, infarct volume and cerebral atrophy at doses of 2 and 4 g/kg after ischemia; and significantly increased the neuron density in the ischemic hippocampal CA1 region, striatum and cortex at dose of 4 g/kg but only increase the density in hippocampal CA1 region at dose of 2 g/kg.
  
  
  
  Chinese herb medicine HJDT has neuroprotective effects on chronic brain injury after focal cerebral ischemia in mice.
authors.affiliation: Department of Pharmacology, Zhejiang Medical College, Hangzhou 310053, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yi-Lu
authors.initials: YL
authors.lastname: Ye
authors.forename: Yin-Xue
authors.initials: YX
authors.lastname: Yan
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Zhang
authors.forename: Li-Sheng
authors.initials: LS
authors.lastname: Chu
authors.forename: Er-Qing
authors.initials: EQ
authors.lastname: Wei
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Yu
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D009474:Neurons / Q000473:pathology; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; C061676:oren gedoku to