title: Double-balloon enteroscopy in Crohn's disease patients suspected of small bowel activity: findings and clinical impact.
abstract: BACKGROUND
  It is estimated that 10-30% of patients with Crohn's disease (CD) have small bowel (SB) involvement, but the exact frequency and clinical relevance of these findings is unknown. Double-balloon enteroscopy (DBE) enables endoscopic visualization of the SB. In this study we evaluated whether DBE is a feasible technique for detection of CD localized in the SB in CD patients with clinical suspicion of SB lesions and whether these findings have clinical impact.
  
  
  METHODS
  Retrospectively we analyzed 52 DBE procedures in 40 CD patients (16 males, mean age 40 years, mean duration of CD 15 years). Included patients had clinical suspicion of small bowel CD activity, including persistent abdominal discomfort (n = 27), iron deficiency anemia (n = 9) and/or hypomagnesemia (n = 4).
  
  
  RESULTS
  Active small bowel CD was found in 24 (60%) patients, leading to a change in therapy in 18 patients (75%). After a mean follow-up of 13 months, 15 (83%) had persistent clinical improvement with a significant drop of mean CDAI from 178 to 90, after a mean follow-up of 13 months.
  
  
  CONCLUSIONS
  DBE is a useful diagnostic tool for the evaluation of SB lesions in CD patients. The significance of these findings is emphasized by the fact that adjustment of therapy in the majority of these patients leads to significant and sustained clinical improvement.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC University Medical Center, 's Gravendijkwal 230, 3015 CE, Rotterdam, The Netherlands. p.mensink@erasmusmc.nl
authors.forename: P B F
authors.initials: PB
authors.lastname: Mensink
authors.forename: M J
authors.initials: MJ
authors.lastname: Groenen
authors.forename: H R
authors.initials: HR
authors.lastname: van Buuren
authors.forename: E J
authors.initials: EJ
authors.lastname: Kuipers
authors.forename: C J
authors.initials: CJ
authors.lastname: van der Woude
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000209:etiology; D002404:Catheterization; D003424:Crohn Disease / Q000175:diagnosis* / Q000503:physiopathology; D016099:Endoscopy, Gastrointestinal / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007421:Intestine, Small / Q000473:pathology*; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D008274:Magnesium