title: Candida glabrata endophthalmitis following penetrating keratoplasty.
abstract: We report a case of Candida glabrata endophthalmitis following penetrating keratoplasty in a 57-year-old man. The infection was thought to be treated successfully with intravitreal amphotericin B but flared 7 months later following cataract extraction and eventually required explantation of the intraocular lens and therapeutic keratoplasty. The literature regarding this rare infection is reviewed. Candida glabrata, an uncommon ocular pathogen, is being reported with increasing frequency and with a notable predilection for post-keratoplasty eyes. In the 10 reported cases, there is 100% concordance between host and donor tissue cultures. In half the cases, there was a latent period of several months. These infections can be difficult to treat because C glabrata is often resistant to the antifungal agents commonly used to treat Candida albicans.
authors.affiliation: Duke University Eye Center, Duke University Medical Center, Durham, North Carolina 27701, USA. matthew.caldwell@duke.edu
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Caldwell
authors.forename: John R
authors.initials: JR
authors.lastname: Perfect
authors.forename: Alan N
authors.initials: AN
authors.lastname: Carlson
authors.forename: Alan D
authors.initials: AD
authors.lastname: Proia
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D041221:Candida glabrata / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D018918:Phacoemulsification; D012008:Recurrence
chemical_list: D000935:Antifungal Agents