HIV-1 Vpr: a novel role in regulating RNA splicing.
Pre-mRNA splicing is a critical step in gene expression for metazoans. Several viral proteins regulate the splicing of pre-mRNAs through complex interactions with the host cell RNA splicing machinery. Here, we focus on a novel function of HIV-1 Vpr, which selectively inhibits cellular and viral pre-mRNA splicing via interactions with components of the spliceosome complex. This review discusses our current knowledge of how RNA splicing regulation is accomplished by Vpr-host factor interactions.
Zhang
Xianfeng
X
Institute for Genetic Medicine, Hokkaido University, Kita-ku, Sapporo, Japan.
Aida
Yoko
Y
D005786:Gene Expression Regulation; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D012326:RNA Splicing; D054325:vpr Gene Products, Human Immunodeficiency Virus / Q000502:physiology*
D054325:vpr Gene Products, Human Immunodeficiency Virus; C514912:vpr protein, Human immunodeficiency virus 1