HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing.
The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.
Chatterjee
Somik
S
Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, 44272, USA.
Wang
Jason W
JW
Cismowski
Mary J
MJ
Bower
John R
JR
Rosenthal
Kenneth Steven
KS
D000818:Animals; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D015870:Gene Expression; D018259:Herpesvirus 1, Human / Q000235:genetics*; D018258:Herpesvirus 2, Human / Q000235:genetics*; D011499:Protein Processing, Post-Translational; D014709:Vero Cells; D014759:Viral Envelope Proteins / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
C540071:ICP34.5 protein, human herpesvirus-2; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C066469:gamma 34.5 protein, Human herpesvirus 1; C038535:glycoprotein gC, herpes simplex virus type 1