title: Mycobacterium abscessus from respiratory isolates: activities of drug combinations.
abstract: Mycobacterium abscessus is the most resistant of rapidly growing pathogenic mycobacteria. We performed a screening of the in vitro sterilizing capacity of various antibiotic combinations against two strains isolated from respiratory samples (in vitro activity of each antibiotic: 51 combinations of two drugs and 47 of three drugs). Our findings confirm that clarithromycin is the most useful drug. The combination of this drug with linezolid exhibits good activity. In addition, the fluoroquinolones and rifabutin in association with clarithromycin may have clinical utility because they are administered orally. Therapeutic alternatives in this type of infections should be evaluated in greater depth.
authors.affiliation: Section of Microbiology and Section of Pneumology, Hospital General Universitario de Elche, Camí de L'Almàssera, no. 11, 03203, Elche, Spain.
authors.forename: Rosa
authors.initials: R
authors.lastname: Cremades
authors.forename: Ana
authors.initials: A
authors.lastname: Santos
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Rodríguez
authors.forename: Eduardo
authors.initials: E
authors.lastname: Garcia-Pachón
authors.forename: Montserrat
authors.initials: M
authors.lastname: Ruiz
authors.forename: Gloria
authors.initials: G
authors.lastname: Royo
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009165:Mycobacterium Infections, Nontuberculous / Q000453:epidemiology / Q000382:microbiology*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects* / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000453:epidemiology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents