title: Inhibitory effects of 6-(3-hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis.
abstract: As a part of an ongoing project searching for new skin-lightening agents, the inhibitory property of 6-(3-Hydroxyphenyl)-2-naphthol (HPN) on melanogenesis was investigated. The inhibitory action of HPN (IC(50)=15.2 muM) on mushroom tyrosinase was revealed. To further explore the action of HPN on melanogenesis, the inhibition of tyrosinase and melanin levels were measured in B16 melanoma cells (B16 cells). Results show that HPN inhibited tyrosinase activity and reduced melanin in B16 cells. Therefore, our data indicate HPN as a new candidate for depigmentation reagents.
authors.affiliation: College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan 609-735, Korea.
authors.forename: Sang Woon
authors.initials: SW
authors.lastname: Chung
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Ha
authors.forename: You Jung
authors.initials: YJ
authors.lastname: Kim
authors.forename: Suhee
authors.initials: S
authors.lastname: Song
authors.forename: Hyojin
authors.initials: H
authors.lastname: Lee
authors.forename: Hongsuk
authors.initials: H
authors.lastname: Suh
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
mesh_terms: D000363:Agaricales / Q000201:enzymology; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008546:Melanoma, Experimental; D051379:Mice; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D009284:Naphthols / Q000737:chemistry / Q000494:pharmacology*; D012880:Skin Pigmentation / Q000187:drug effects
chemical_list: C540204:6-(3-hydroxyphenyl)-2-naphthol; D008543:Melanins; D009284:Naphthols; D014442:Monophenol Monooxygenase