title: Synthesis of 1,3-diamines through rhodium-catalyzed C-H insertion.
abstract: A grand opening: N-Boc-N-alkylsulfamides are effective substrates for the title transformation. Oxidative cyclization is highly chemoselective as well as being both stereospecific and diastereoselective. With the advent of new protocols that facilitate ring opening of the six-membered-ring heterocyclic products, access to differentially protected 1,3-diamines has been made possible (see scheme).
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kurokawa
authors.forename: Mihyong
authors.initials: M
authors.lastname: Kim
authors.forename: J
authors.initials: J
authors.lastname: Du Bois
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003959:Diamines / Q000138:chemical synthesis* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003959:Diamines; D002244:Carbon; D006859:Hydrogen; D012238:Rhodium