title: Dumbbell-like Au-Fe3O4 nanoparticles for target-specific platin delivery.
abstract: Dumbbell-like Au-Fe(3)O(4) nanoparticles (NPs) were made and coupled with Herceptin and a platin complex. The platin-Au-Fe(3)O(4)-Herceptin NPs act as a target-specific nanocarriers for delivery of platin into Her2-positive breast cancer cells (Sk-Br3) with strong therapeutic effects. The conjugate has a half-maximal inhibitory concentration (IC(50)) toward Sk-Br3 cells of 1.76 microg of Pt/mL, which is lower than that needed for cisplatin (3.5 microg/mL). The work demonstrates that the dumbbell-like Au-Fe(3)O(4) NPs are promising nanocarriers for highly sensitive diagnostic and therapeutic applications.
authors.affiliation: Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
authors.forename: Chenjie
authors.initials: C
authors.lastname: Xu
authors.forename: Baodui
authors.initials: B
authors.lastname: Wang
authors.forename: Shouheng
authors.initials: S
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000008:administration & dosage*; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D007501:Iron / Q000737:chemistry*; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D049329:Nanostructures; D036103:Nanotechnology; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D006046:Gold; D007501:Iron; D002945:Cisplatin