title: Necrotizing fasciitis: microbiological characteristics and predictors of postoperative outcome.
abstract: OBJECTIVE
  Necrotizing fasciitis is a life threatening soft-tissue infection with a high morbidity and mortality. Prompt treatment based on extensive surgical debridement and antibiotic therapies are the therapeutic principles.
  
  
  METHODS
  The medical records of patients with necrotizing fasciitis (n = 26) from 1996 to 2005 were retrospectively analyzed.
  
  
  RESULTS
  The localization of necrotizing fasciitis was most commonly the trunk (42.3 %). Type I polymicrobial infection was the dominating infection. The involvement of anaerobic bacteria was associated with an increase in the number of surgical revisions (p = 0.005). Length of postoperative intensive care unit stay, duration of postoperative ventilation and mortality were significantly increased in the ASA IV-V group. Computed tomography displayed only a limited significance as diagnostic tool for initial diagnosis.
  
  
  CONCLUSIONS
  In severe cases the combination of necrotic skin and soft tissue gas facilitates the correct diagnosis, which should than be followed by immediate - and most often - repeated debridement. If anaerobes are isolated an early and aggressive second look is necessary.
authors.affiliation: Department of General Surgery, Heinrich Heine University, Moorenstr. 5, 40225 Duesseldorf, Germany. andreas.krieg@med.uni-duesseldorf.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Krieg
authors.forename: A
authors.initials: A
authors.lastname: Röhrborn
authors.forename: J
authors.initials: J
authors.lastname: Schulte Am Esch
authors.forename: D
authors.initials: D
authors.lastname: Schubert
authors.forename: L W
authors.initials: LW
authors.lastname: Poll
authors.forename: C
authors.initials: C
authors.lastname: Ohmann
authors.forename: S
authors.initials: S
authors.lastname: Braunstein
authors.forename: W T
authors.initials: WT
authors.lastname: Knoefel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001421:Bacteria, Anaerobic / Q000302:isolation & purification*; D003422:Critical Care; D003646:Debridement; D019115:Fasciitis, Necrotizing / Q000175:diagnosis / Q000382:microbiology* / Q000401:mortality / Q000628:therapy; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D019651:Plastic Surgery Procedures; D012086:Reoperation; D012121:Respiration, Artificial; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents