3D pressure field in lipid membranes and membrane-protein complexes.
We calculate full 3D pressure fields for inhomogeneous nanoscale systems using molecular dynamics simulation data. The fields represent systems with increasing level of complexity, ranging from semivesicles and vesicles to membranes characterized by coexistence of two phases, including also a protein-membrane complex. We show that the 3D pressure field is distinctly different for curved and planar bilayers, the pressure field depends strongly on the phase of the membrane, and that an integral protein modulates the tension and elastic properties of the membrane.
Ollila
O H Samuli
OH
Department of Physics, Tampere University of Technology, P.O. Box 692, FI-33101 Tampere, Finland.
Risselada
H Jelger
HJ
Louhivuori
Martti
M
Lindahl
Erik
E
Vattulainen
Ilpo
I
Marrink
Siewert J
SJ
D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000378:metabolism; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008563:Membrane Lipids / Q000737:chemistry* / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism; D008954:Models, Biological; D008956:Models, Chemical
D029968:Escherichia coli Proteins; D007473:Ion Channels; D008051:Lipid Bilayers; D008563:Membrane Lipids; D008565:Membrane Proteins; C086596:MscL protein, E coli; D015060:1,2-Dipalmitoylphosphatidylcholine