vfr, a novel locus affecting cysteine protease production in Streptococcus pyogenes.
A gene unique to Streptococcus pyogenes, called vfr, that negatively regulates speB, an important extracellular proteinase, has been identified. Disruption of vfr markedly increased SpeB production in a clinical strain of S. pyogenes and relieved its growth phase dependency. These findings may provide important insights into the pathogenesis of invasive S. pyogenes infections.
Ma
Yongsheng
Y
Research & Development Service, Veterans Affairs Medical Center, 500 West Fort St. (Bldg. 45), Boise, ID 83702, USA. yongsheng.ma@va.gov
Bryant
Amy E
AE
Salmi
Dan B
DB
McIndoo
Eric
E
Stevens
Dennis L
DL
D001426:Bacterial Proteins / Q000096:biosynthesis*; D004251:DNA Transposable Elements; D005098:Exotoxins / Q000096:biosynthesis*; D015964:Gene Expression Regulation, Bacterial; D055786:Gene Knockout Techniques; D006801:Humans; D016254:Mutagenesis, Insertional; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D013297:Streptococcus pyogenes / Q000201:enzymology* / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D005098:Exotoxins; D012097:Repressor Proteins; C027951:erythrogenic toxin