title: Spatial patterns in discordant diagnostic test results for Chagas disease: links to transmission hotspots.
abstract: Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.
authors.affiliation: Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA. mzlevy@sas.upenn.edu
authors.forename: Michael Z
authors.initials: MZ
authors.lastname: Levy
authors.forename: Natalie M
authors.initials: NM
authors.lastname: Bowman
authors.forename: Vivian
authors.initials: V
authors.lastname: Kawai
authors.forename: Joshua B
authors.initials: JB
authors.lastname: Plotkin
authors.forename: Lance A
authors.initials: LA
authors.lastname: Waller
authors.forename: Lilia
authors.initials: L
authors.lastname: Cabrera
authors.forename: Frank
authors.initials: F
authors.lastname: Steurer
authors.forename: Amy E
authors.initials: AE
authors.lastname: Seitz
authors.forename: Viviana V
authors.initials: VV
authors.lastname: Pinedo-Cancino
authors.forename: Juan Geny
authors.initials: JG
authors.lastname: Cornejo del Carpio
authors.forename: Eleazar
authors.initials: E
authors.lastname: Cordova Benzaquen
authors.forename: F Ellis
authors.initials: FE
authors.lastname: McKenzie
authors.forename: James H
authors.initials: JH
authors.lastname: Maguire
authors.forename: Robert H
authors.initials: RH
authors.lastname: Gilman
authors.forename: Caryn
authors.initials: C
authors.lastname: Bern
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000175:diagnosis* / Q000453:epidemiology* / Q000635:transmission; D016000:Cluster Analysis; D003198:Computer Simulation; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D010568:Peru / Q000453:epidemiology; D015531:Radioimmunoprecipitation Assay; D013997:Time Factors; D019371:Topography, Medical; D014349:Trypanosoma cruzi / Q000302:isolation & purification*