Diacylglycerol kinases as sources of phosphatidic acid.
There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA). They do so in some cases by associating with proteins and then modifying their activity by generating PA. In other cases, DGKs broadly regulate signaling events by virtue of their ability to provide PA for the synthesis of phosphatidylinositols (PtdIns).
Cai
Jinjin
J
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.
Abramovici
Hanan
H
Gee
Stephen H
SH
Topham
Matthew K
MK
D000818:Animals; D019852:Diacylglycerol Kinase / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D010712:Phosphatidic Acids / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
D010712:Phosphatidic Acids; D010716:Phosphatidylinositols; D019852:Diacylglycerol Kinase