New directions for induction immunosuppression strategy in solid organ transplantation.
BACKGROUND
Solid organ transplant centers are increasingly using induction immunosuppression strategies. Induction immunosuppression involves the use of intense therapy at the time of transplantation with the goal of preventing acute rejection and ultimately inducing a tolerogenic state. The objective of this review is to examine specialized induction agents currently in clinical use and highlight novel therapeutics on the horizon for induction immunosuppression.


METHODS
A literature search using the PubMed and MEDLINE databases identified salient basic science and clinical research articles on induction immunosuppression for solid organ transplantation.


CONCLUSIONS
While current induction immunosuppression agents have reduced the incidence of acute rejection, the goal of transplant tolerance has not been realized. Furthermore, the long-term allograft survival rate is not clearly influenced by the practice of induction immunosuppression. New approaches to tolerance induction, such as costimulatory-based therapy, mixed chimerism, and adoptive cellular transfer, hold promise for more effective induction immunosuppression in solid organ transplantation.
Hawksworth
Jason S
JS
Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA.
Leeser
David
D
Jindal
Rahul M
RM
Falta
Edward
E
Tadaki
Douglas
D
Elster
Eric A
EA
D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000639:trends; D007166:Immunosuppressive Agents / Q000008:administration & dosage* / Q000276:immunology; D016377:Organ Transplantation; D023001:Transplantation Tolerance / Q000276:immunology
D007166:Immunosuppressive Agents