title: Structure of new monoterpene glycoside from Sibiraea angustata RCHD. and its anti-obestic effect.
abstract: A new monoterpene glycoside (1) isolated from the aerial part of Sibirae angustata RCHD. (Rosaceae) was found to be 1-O-beta-D-glucopyranosyl-geraniol-5,10-olide and named as sibiskoside. Acute toxicity study revealed that oral administration of 1 (2.5 g/kg body weight) to mice resulted in no death and no evidence of abnormalities in internal organs. Its oral administration to the mice reared with high-fat diet resulted in weight-loss, which was also reflected in serum triglyceride and sugar level, and the weight of abdominal fat. Sibiskoside could be considered to be an active ingredient of Liucha for exerting weight-loss effect in a drink of S. angustata.
authors.affiliation: Iskra Industry Co., Ltd, Chuo-ku, Tokyo 103-0027, Japan. y.ito@iskra.co.jp
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ito
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kamo
authors.forename: Samir Kumar
authors.initials: SK
authors.lastname: Sadhu
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohtsuki
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kano
mesh_terms: D000080462:Acyclic Monoterpenes; D000284:Administration, Oral; D000818:Animals; D019440:Anti-Obesity Agents / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D010936:Plant Extracts / Q000737:chemistry; D027824:Rosaceae / Q000737:chemistry*
chemical_list: C539544:1-O-beta-D-glucopyranosyl-geraniol-5,10-olide; D000080462:Acyclic Monoterpenes; D019440:Anti-Obesity Agents; D006027:Glycosides; D039821:Monoterpenes; D010936:Plant Extracts