Phloroglucinol-based biomimetic adhesives for medical applications.
An adhesive that functions well under moist conditions could facilitate many surgical procedures. In recent studies we designed novel biomimetic glues which mimic the adhesion mechanism of algae, renowned for their remarkable adherence to wet surfaces. Here we extend our previous studies and propose biomimetic formulations, composed of alginate gel and native phloroglucinol, that do not induce cell cytotoxicity. Characterization of the adherence to tissues showed that adhesion was directly related to the mechanical strength of the cross-linked alginate. Therefore the adhesion strength can be altered by changing the source of the calcium cross-linker, the alginate G-content or the molecular weight of the alginate. The adhesion strength was comparable to that of Tisseel, a commercial tissue adhesive.
Bitton
Ronit
R
Inter-Departmental Program for Biotechnology, Technion-Israel Institute of Technology, Technion City, Haifa 32000, Israel.
Josef
Elinor
E
Shimshelashvili
Irena
I
Shapira
Keren
K
Seliktar
Dror
D
Bianco-Peled
Havazelet
H
D000464:Alginates / Q000737:chemistry; D000818:Animals; D040761:Biomimetic Materials / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D008970:Molecular Weight; D009132:Muscles / Q000187:drug effects; D010696:Phloroglucinol / Q000494:pharmacology*; D034421:Sus scrofa; D013718:Tensile Strength / Q000187:drug effects; D014014:Tissue Adhesives / Q000494:pharmacology*
D000464:Alginates; D015718:Fibrin Tissue Adhesive; D006603:Hexuronic Acids; D014014:Tissue Adhesives; D020723:Glucuronic Acid; D010696:Phloroglucinol