title: Efficient three-component Strecker reaction of aldehydes/ketones via NHC-amidate palladium(II) complex catalysis.
abstract: A simple and efficient one-pot, three-component method has been developed for the synthesis of alpha-aminonitriles. This Strecker reaction is applicable for aldehydes and ketones with aliphatic or aromatic amines and trimethylsilyl cyanide in the presence of a palladium Lewis acid catalyst in dichloromethane solvent at room temperature.
authors.affiliation: Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, California 90089-0166, USA.
authors.forename: Jamie
authors.initials: J
authors.lastname: Jarusiewicz
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Choe
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Yoo
authors.forename: Chan Pil
authors.initials: CP
authors.lastname: Park
authors.forename: Kyung Woon
authors.initials: KW
authors.lastname: Jung
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000577:Amides; D006571:Heterocyclic Compounds; D007659:Ketones; C030011:carbene; D010165:Palladium; D008697:Methane