MDM2 309 T/G polymorphism is associated with lung cancer risk among Asians.
Published data on the association between MDM2 309 T/G polymorphism and lung cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of eight studies including 6063 cases and 6678 controls were involved in this meta-analysis. Overall, significantly elevated lung cancer risk was associated with GG variant genotype in recessive model when all the eligible studies were pooled into the meta-analysis (OR=1.17; 95% CI=1.02-1.34; P(heterogeneity)=0.06). In the subgroup analysis by ethnicity, significantly increased risks were found among Asians for TG versus TT (OR=1.20; 95% CI=1.05-1.37; P(heterogeneity)=0.30), GG versus TT (OR = 1.34; 95% CI=1.01-1.79; P(heterogeneity)=0.03) and dominant model (OR=1.26; 95% CI=1.11-1.43; P(heterogeneity)=0.14). However, no significant associations were found in both Europeans and Africans for all genetic models. This meta-analysis suggests that the MDM2 309G allele is a low-penetrant risk factor for developing lung cancer in Asians.
Gui
Xian-Hua
XH
Department of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Qiu
Li-Xin
LX
Zhang
Hai-Feng
HF
Zhang
De-Ping
DP
Zhong
Wen-Zhao
WZ
Li
Jin
J
Xiao
Yong-Long
YL
D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012306:Risk; D012907:Smoking / Q000009:adverse effects
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2