title: Highly enantioselective and diastereoselective synthesis of chiral amino alcohols by ruthenium-catalyzed asymmetric hydrogenation of alpha-amino aliphatic ketones.
abstract: A highly efficient asymmetric hydrogenation of racemic acyclic alpha-amino aliphatic ketones via dynamic kinetic resolution has been realized, providing chiral amino alcohols in excellent enantioselectivities and diastereoselectivities. A hydrogen-bonding transition state mode was proposed for explaining the high diastereoselectivity and enantioselectivity of the reaction.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Sheng
authors.initials: S
authors.lastname: Liu
authors.forename: Wei-Ling
authors.initials: WL
authors.lastname: Kong
authors.forename: Wen-Ju
authors.initials: WJ
authors.lastname: Bai
authors.forename: Xiao-Chen
authors.initials: XC
authors.lastname: Wang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou