title: Unfinished business: Incomplete laminin processing exposes a tumor target.
abstract: The G45 domain of laminin-332 is cleaved in normal tissues but remains in squamous cell carcinomas. Targeting this domain using a G45 antibody reduced in vivo tumor growth and invasion and suggests a role for G45 as a new therapeutic target.
authors.affiliation: Vascular Biology Program, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. jacqueline.banyard@childrens.harvard.edu
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Banyard
mesh_terms: D018450:Disease Progression; D006801:Humans; D007797:Laminin / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
chemical_list: D007797:Laminin