First total synthesis of antiostatin A1, a potent carbazole-based naturally occurring antioxidant.
The first total synthesis of the potent antioxidant antiostatin A1 is reported, where its key features rely on a chemo- and regioselective rhodium-catalysed crossed alkyne cyclotrimerisation reaction applying functionalised ynamides and a palladium-catalysed arylamidation reaction.
Alayrac
Carole
C
Laboratoire de Chimie Moléculaire et Thio-organique, ENSICAEN, Université de Caen Basse-Normandie, CNRS, 6 Boulevard du Maréchal Juin, 14050, Caen, France.
Schollmeyer
Dieter
D
Witulski
Bernhard
B
D000975:Antioxidants / Q000737:chemistry*; D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry; D013237:Stereoisomerism
D000975:Antioxidants; D002227:Carbazoles; C540617:antiostatin A1; C041514:carbazole; D010165:Palladium; D012238:Rhodium