Enhancement of aluminum intake of mice by specific amino acids: long-term dosing.
Aluminum ion was administered orally to mice for a long period (80 weeks). Aluminum, magnesium, and calcium in the urine were measured weekly, and aluminum in organs, i.e., brain, kidney, liver, heart, lung, and bone, was measured in the final stage. Calcium in the bones was also measured. The results of the urine tests suggest that aluminum ion is hardly absorbed by mice if it is dosed alone. Aluminum ion administered with glycine or glutamic acid is accumulated in vivo, but the presence of tryptophane has little influence on aluminum incorporation. When aluminum remains in the body, the calcium and magnesium excretions increase. The long-term administration of aluminum resulted in the accumulation of aluminum in all organs. The amount of aluminum increased distinctly in all organs. It notably increased when aluminum was dosed with either glycine or glutamic acid. Special attention should be paid to the fact that aluminum amounts in the brain and bones are very high when dosed with either glycine or glutamic acid.
Aikoh
Hiromi
H
Department of Chemistry, Okayama University of Science, Okayama City 700-0005, Japan. aikoh@chem.ous.ac.jp
Yamato
Masaaki
M
Shibahara
Takashi
T
D000535:Aluminum / Q000008:administration & dosage* / Q000378:metabolism / Q000652:urine; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism / Q000652:urine; D004357:Drug Synergism; D005260:Female; D018698:Glutamic Acid / Q000008:administration & dosage*; D005998:Glycine / Q000008:administration & dosage*; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism / Q000652:urine; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D014018:Tissue Distribution / Q000187:drug effects; D014364:Tryptophan / Q000008:administration & dosage*
D018698:Glutamic Acid; D014364:Tryptophan; D000535:Aluminum; D008274:Magnesium; D002118:Calcium; D005998:Glycine