title: Enantioselective synthesis of C2-symmetric spirobilactams via Pd-catalyzed intramolecular double N-arylation.
abstract: A Pd/BINAP-complex-catalyzed enantioselective intramolecular double N-arylation of malonamides bearing 2-bromoarylmethyl groups furnished C(2)-symmetric spirobi(3,4-dihydro-2-quinolone) derivatives in up to 70% ee.
authors.affiliation: The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takenaka
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Itoh
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai