title: Insulin resistance, leptin and monocyte chemotactic protein-1 levels in diabetic and non-diabetic Afro-Caribbean subjects.
abstract: OBJECTIVE
  To determine how the levels of leptin and monocyte chemotactic protein-1 (MCP-1) are associated with insulin resistance (IR) in obese, non-obese, diabetic and non-diabetic subjects.
  
  
  METHODS
  112 type 2 diabetics and 43 non-diabetics were studied fasting. Anthropometric indices were measured and glucose, insulin, leptin and MCP-1 were measured in blood. IR was calculated.
  
  
  RESULTS
  MCP-1 level was significantly higher in diabetics than non-diabetics irrespective of gender (p < 0.05). Irrespective of diabetes status, the serum leptin concentration was significantly higher (p < 0.05) in obese and females subjects than in non-obese and male subjects respectively. There were no significant correlations between IR and MCP-1 or leptin in all subgroups of subjects studied. General linear modelling analysis showed that only diabetes state significantly predicted MCP-1 levels (p < 0.05) whereas non of the factors predicted leptin levels (p > 0.05).
  
  
  CONCLUSIONS
  Routine measurement of leptin and MCP-1 would be potentially useful in assessment of patients for the metabolic syndrome or coronary heart disease especially in black population.
authors.affiliation: The University of the West Indies, St Augustine, Trinidad. cezenwaka@fms.uwi.tt
authors.forename: C E
authors.initials: CE
authors.lastname: Ezenwaka
authors.forename: E
authors.initials: E
authors.lastname: Nwagbara
authors.forename: D
authors.initials: D
authors.lastname: Seales
authors.forename: F
authors.initials: F
authors.lastname: Okali
authors.forename: H
authors.initials: H
authors.lastname: Sell
authors.forename: J
authors.initials: J
authors.lastname: Eckel
mesh_terms: D000349:Africa; D000368:Aged; D000818:Animals; D018932:Chemokine CCL2 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D014300:Trinidad and Tobago
chemical_list: D018932:Chemokine CCL2; D020738:Leptin