Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.
One secobutanolide, two butanolides and six drimane sesquiterpenoids were isolated from the bark and leaves of Zygogynum pancheri and Zygogynum acsmithii (Winteraceae) along with six known drimanes, isodrimanial, 1beta-O-p-methoxy-E-cinnamoyl-bemadienolide, 7-ketoisodrimenin, drimenin, polygodial and 1beta-E-cinnamoyl-6alpha-hydroxypolygodial. Their structures were elucidated through analysis of spectroscopic data. Drimane sesquiterpenoids with a dialdehyde function exhibited significant inhibitory activities in the in vitro cytotoxic assays against KB, HL60 and HCT116 cancer cell lines.
Allouche
Noureddine
N
Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences de Sfax, B.P. 802, 3018 Sfax, Tunisia.
Apel
Cécile
C
Martin
Marie-Thérèse
MT
Dumontet
Vincent
V
Guéritte
Françoise
F
Litaudon
Marc
M
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D009510:New Caledonia; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014329:Tropical Climate; D032423:Winteraceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes