Long-term exercise training attenuates age-related diastolic dysfunction: association of myocardial collagen cross-linking.
The incidence of diastolic heart failure increases dramatically with age. We investigated the impact of long-term exercise training on age-related diastolic dysfunction. Old (25-month-old) male Fischer 344 rats were studied after 12 weeks of treadmill exercise training or sedentary cage life (N=7, in each group). We determined cardiac performance using a pressure-volume conductance catheter and magnetic resonance imaging. Collagen volume fraction (CVF) and myocardial collagen solubility by pepsin as an index of advanced glycation end products (AGEs) cross-linked collagen were measured. The maximal slope of systolic pressure increment (+dP/dt) and the slope of end-systolic pressure-volume relation were higher, and end diastolic volume (EDV), Delta EDV (the percentage of the EDV increment-to-baseline EDV) and the slope of end-diastolic pressure-volume relation were lower in training group. The maximal slope of diastolic pressure decrement (-dP/dt) and time constant of LV pressure decay (tau) had no difference. AGEs cross-linked collagen, not CVF was reduced by exercise training. Long-term exercise training appears to attenuate age-related deterioration in cardiac systolic function and myocardial stiffness and could be reduce in pathologic AGEs cross-linked collagen in myocardium.
Choi
Su-Yeon
SY
Department of Internal Medicine, Seoul National University College of Medicine, Cardiovascular Center, Cardiovascular Research Institute and Healthcare Research Institute, Seoul National University Hospital, Seoul, Korea.
Chang
Hyuk-Jae
HJ
Choi
Sang-Il
SI
Kim
Kwang-Il
KI
Cho
Yong-Seok
YS
Youn
Tae-Jin
TJ
Chung
Woo-Young
WY
Chae
In-Ho
IH
Choi
Dong-Ju
DJ
Kim
Hyo-Soo
HS
Kim
Cheol-Ho
CH
Oh
Byung-Hee
BH
Kim
Mi-Hyang
MH
D000375:Aging; D000818:Animals; D001794:Blood Pressure; D003094:Collagen / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism; D054144:Heart Failure, Diastolic / Q000378:metabolism / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010805:Physical Conditioning, Animal; D051381:Rats; D011916:Rats, Inbred F344; D012995:Solubility; D013318:Stroke Volume / Q000502:physiology
D017127:Glycation End Products, Advanced; D003094:Collagen