Modulatory effects of rutin on biochemical and hematological parameters in hypercholesterolemic Golden Syrian hamsters.
Flavonoids have been reported to exhibit several pharmacological properties, mainly in cardiovascular and inflammatory diseases. In the present study, we observed that rutin, a known glycosylated flavonoid isolated from Dimorphandra mollis, had a lowering effect on plasma triglyceride levels of diet-induced hypercholesterolemic Golden Syrian hamsters, but did not change total cholesterol and high-density lipoprotein cholesterol levels. Moreover, high-fat or rutin supplemented diets showed no immunotoxic effects, since no significant changes were observed on total white blood cells, granulocytes and mononuclear cells, as well as on the neutrophil apoptosis degree, when compared to untreated animals. Therefore, rutin seems to be a selective and non-toxic modulator of hypercholesterolemia, which can be promising for the development of new drugs.
Kanashiro
Alexandre
A
Departamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil, 14040-903.
Andrade
Daiani C O
DC
Kabeya
Luciana M
LM
Turato
Walter M
WM
Faccioli
Lucia H
LH
Uyemura
Sérgio A
SA
Lucisano-Valim
Yara M
YM
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002791:Cholesterol, Dietary / Q000494:pharmacology; D008076:Cholesterol, HDL / Q000097:blood* / Q000187:drug effects; D006224:Cricetinae; D004041:Dietary Fats / Q000494:pharmacology; D006937:Hypercholesterolemia / Q000097:blood* / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D009504:Neutrophils / Q000187:drug effects; D012431:Rutin / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood*
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D004041:Dietary Fats; D014280:Triglycerides; D012431:Rutin