Renal dendritic cells: an update.
Discovery into the role of renal dendritic cells (rDCs) in health and disease of the kidney is rapidly accelerating. Progress in deciphering DC precursors and the heterogeneity of monocyte subsets in mice and humans is providing insight into the biology of rDCs. Recent findings have extended knowledge of the origins, anatomy and function of the rDC network at steady state and during periods of injury to the renal parenchyma. This brief review highlights these new findings and provides an update on the study of rDCs.
Velázquez
Peter
P
Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, N.Y., USA.
Dustin
Michael L
ML
Nelson
Peter J
PJ
D000818:Animals; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000473:pathology; D006085:Graft Survival / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007668:Kidney / Q000166:cytology / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D007674:Kidney Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects