Identification of the novel HLA-G*010112 allele by sequencing genomic DNA of Korean individuals.
Human leukocyte antigen (HLA)-G is an immune modulator that inhibits the functions of cytotoxic T lymphocytes and natural killer cells. Immune modulation of HLA-G plays an important role in the prevention of fetal rejection. We found a novel substitution at nucleotide position 195 (G-T), codon 41 (Ala), in exon 2 of HLA-G. This substitution does not change the amino acid (GCG-->GCT).
Kim
J-G
JG
School of Biological Science and Technology, Pochon CHA University, Sungnam, Korea.
Yun
H-S
HS
Lee
J-K
JK
Kwack
K
K
D000483:Alleles; D044466:Asian People / Q000235:genetics; D001483:Base Sequence; D004247:DNA / Q000737:chemistry*; D005091:Exons; D015894:Genome, Human / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007723:Korea; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA
D006680:HLA Antigens; D059951:HLA-G Antigens; C540900:HLA-G*01:01:12 antigen; D015395:Histocompatibility Antigens Class I; D004247:DNA