title: Escherichia coli keratitis treated with ultraviolet A/riboflavin corneal cross-linking: a case report.
abstract: OBJECTIVE
  To describe a case of keratitis caused by the Gram-negative Escherichia coli, treated with UVA-riboflavin cross linking.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 78-year-old woman with diabetes presented with a 1-week history of pain, photophobia, foreign body sensation, and lacrimation in the right eye. The patient underwent topical and systemic antimicrobial therapy, without improvement. The authors treated the patient with riboflavin and corneal UVA crosslinking, with the aim to promote healing of the ulceration. One day after the procedure, the corneal ulceration was covered by cicatricial tissue, and the patient reported a significant improvement in symptoms. One month after the treatment, corneal edema was almost completely resolved, corneal ulceration was healed, and the painful symptoms of the patient had disappeared.
  
  
  CONCLUSIONS
  UVA-riboflavin crosslinking can be useful for the treatment of corneal ulceration unresponsive to medical treatment.
authors.affiliation: UOC Oculistica, Ospedale Generale Regionale F. Miulli, Acquaviva delle Fonti, Bari - Italy. tommasomicelliferrari@alice.it
authors.forename: Tommaso
authors.initials: T
authors.lastname: Micelli Ferrari
authors.forename: Marco
authors.initials: M
authors.lastname: Leozappa
authors.forename: Massimo
authors.initials: M
authors.lastname: Lorusso
authors.forename: Enrico
authors.initials: E
authors.lastname: Epifani
authors.forename: Luisa
authors.initials: L
authors.lastname: Micelli Ferrari
mesh_terms: D000368:Aged; D003094:Collagen / Q000378:metabolism; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000378:metabolism / Q000382:microbiology; D005260:Female; D006801:Humans; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D012256:Riboflavin / Q000627:therapeutic use*; D014466:Ultraviolet Rays
chemical_list: D017319:Photosensitizing Agents; D003094:Collagen; D012256:Riboflavin