title: Gene regulation by voltage-dependent calcium channels.
abstract: Ca2+ is the most widely used second messenger in cell biology and fulfills a plethora of essential cell functions. One of the most exciting findings of the last decades was the involvement of Ca2+ in the regulation of long-term cell adaptation through its ability to control gene expression. This finding provided a link between cell excitation and gene expression. In this review, we chose to focus on the role of voltage-dependent calcium channels in mediating gene expression in response to membrane depolarization. We illustrate the different pathways by which these channels are involved in excitation-transcription coupling, including the most recent Ca2+ ion-independent strategies that highlight the transcription factor role of calcium channels.
authors.affiliation: Grenoble Institute of Neuroscience, Inserm U 836-Team 3 Calcium Channels, Functions and Pathologies, Bâtiment Edmond Safra, Université Joseph Fourier, Site santé de la Tronche, BP 170, 38042 Grenoble cedex 9, France.
authors.forename: Maud
authors.initials: M
authors.lastname: Barbado
authors.forename: Katell
authors.initials: K
authors.lastname: Fablet
authors.forename: Michel
authors.initials: M
authors.lastname: Ronjat
authors.forename: Michel
authors.initials: M
authors.lastname: De Waard
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D015290:Second Messenger Systems / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D014157:Transcription Factors; D002118:Calcium