title: Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species.
abstract: The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine beta-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of beta-lactams, quinolones, and chloramphenicol.
authors.affiliation: Université de la Méditerranée, UMR-MD1, IFR88, Faculté de Médecine, 13385 Marseille Cedex 05, France.
authors.forename: Vannina
authors.initials: V
authors.lastname: Lorenzi
authors.forename: Alain
authors.initials: A
authors.lastname: Muselli
authors.forename: Antoine François
authors.initials: AF
authors.lastname: Bernardini
authors.forename: Liliane
authors.initials: L
authors.lastname: Berti
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Pagès
authors.forename: Leonard
authors.initials: L
authors.lastname: Amaral
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bolla
mesh_terms: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004357:Drug Synergism; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D036562:Helichrysum / Q000737:chemistry*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents; D004151:Dipeptides; D015363:Quinolones; D013729:Terpenes; D047090:beta-Lactams; C419365:phenylalanine arginine beta-naphthylamide; D002701:Chloramphenicol; C007836:geraniol