title: Physical function in older candidates for renal transplantation: an impaired population.
abstract: OBJECTIVE
  Although physical function is a major determinant of health outcomes and quality of life in older adults, standard tools for its assessment have not been routinely applied to the fastest growing segment of the kidney transplant candidate population, which is at high risk of comorbidity and disability--people over age 60. The objective of this study was to describe the baseline physical function in older adults with renal failure referred for transplantation and compare them with older adults with other significant comorbidity.
  
  
  METHODS
  An observational sample comparing physical performance in renal transplant candidates over age 60 (Renal Failure) to older people with diastolic heart failure (Heart Failure), chronic obstructive pulmonary disease (COPD), or at high risk for cardiovascular disease (High CV Risk) was studied.
  
  
  RESULTS
  Older people with Renal Failure were significantly impaired by objective measures of physical function, including lower Short Physical Performance Battery, slower gait speed, and lower grip strength.
  
  
  CONCLUSIONS
  Older people referred for renal transplantation had poorer physical performance than older adults with other common chronic diseases and may be at high risk for disability while awaiting transplantation.
authors.affiliation: Department of Internal Medicine, Wake Forest University Health Sciences, Section on Nephrology, Medical Center Boulevard Winston-Salem, NC 27157, USA. ehartman@wfubmc.edu
authors.forename: Erica L
authors.initials: EL
authors.lastname: Hartmann
authors.forename: Dalane
authors.initials: D
authors.lastname: Kitzman
authors.forename: Michael
authors.initials: M
authors.lastname: Rocco
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Leng
authors.forename: Heidi
authors.initials: H
authors.lastname: Klepin
authors.forename: Michelle
authors.initials: M
authors.lastname: Gordon
authors.forename: Jack
authors.initials: J
authors.lastname: Rejeski
authors.forename: Michael
authors.initials: M
authors.lastname: Berry
authors.forename: Stephen
authors.initials: S
authors.lastname: Kritchevsky
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004185:Disability Evaluation; D005260:Female; D018737:Hand Strength; D054144:Heart Failure, Diastolic / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis* / Q000503:physiopathology; D011788:Quality of Life; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014850:Waiting Lists; D016138:Walking