Antioxidant effects of some drugs on ethanol-induced ulcers.
The aim of this work was to investigate the antioxidant potential of some commonly used drugs (bromocriptine, haloperidol and azithromycin) on alcohol-induced ulcers in the rat. The following parameters were determined: content of reduced glutathione, activities of catalase, xanthine oxidase, glutathione reductase, glutathione peroxidase, peroxidase, and lipid peroxidation intensity. A battery of biochemical assays were used and the resulting data was statistically analyzed. Alcohol stress caused gastric ulcerations and hemorrhages and changed all the examined parameters except glutathione peroxidase activity. All drugs reduced the ulcer index and hemorrhages, with azithromycin showing the strongest effects. The drugs in combination with alcohol showed different effects on biochemical parameters. Our results indicate that the gastroprotective effects of the investigated drugs on experimental lesions induced by 100% ethanol could not be correlated with their antioxidative properties.
Popovic
Mira
M
Department of Chemistry, University of Novi Sad, Serbia. popovic@ih.ns.ac.yu
Janicijevic-Hudomal
Snezana
S
Kaurinovic
Biljana
B
Rasic
Julijana
J
Trivic
Svetlana
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism / Q000627:therapeutic use*; D017963:Azithromycin / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D018491:Dopamine Agonists / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D000431:Ethanol / Q000009:adverse effects*; D006220:Haloperidol; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology
D000900:Anti-Bacterial Agents; D000975:Antioxidants; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D001971:Bromocriptine; D000431:Ethanol; D017963:Azithromycin; D006220:Haloperidol