Organization, integration, and assembly of genetic and epigenetic regulatory machinery in nuclear microenvironments: implications for biological control in cancer.
There is growing awareness that the fidelity of gene expression necessitates coordination of transcription factor metabolism and organization of genes and regulatory proteins within the three-dimensional context of nuclear architecture. The regulatory machinery that governs genetic and epigenetic control of gene expression is compartmentalized in nuclear microenvironments. Temporal and spatial parameters of regulatory complex organization and assembly are functionally linked to biological control and are compromised with the onset and progression of tumorigenesis. High throughput imaging of cells, tissues, and tumors, including live cell analysis, is expanding research's capabilities toward translating components of nuclear organization into novel strategies for cancer diagnosis and therapy.
Stein
Gary S
GS
University of Massachusetts Medical School, Department of Cell Biology and Cancer Center, Worcester, Massachusetts 01655, USA. Gary.Stein@umassmed.edu
Zaidi
Sayyed K
SK
Stein
Janet L
JL
Lian
Jane B
JB
van Wijnen
Andre J
AJ
Montecino
Martin
M
Young
Daniel W
DW
Javed
Amjad
A
Pratap
Jitesh
J
Choi
Je-Yong
JY
Ali
Syed A
SA
Pande
Sandhya
S
Hassan
Mohammad Q
MQ
D002467:Cell Nucleus / Q000235:genetics*; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D044127:Epigenesis, Genetic; D015870:Gene Expression; D006801:Humans; D008938:Mitosis; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D014157:Transcription Factors