Modeling cell migration in 3D: Status and challenges.
Cell migration is a multi-scale process that integrates signaling, mechanics and biochemical reaction kinetics. Various mathematical models accurately predict cell migration on 2D surfaces, but are unable to capture the complexities of 3D migration. Additionally, quantitative 3D cell migration models have been few and far between. In this review we look and characterize various mathematical models available in literature to predict cell migration in 3D matrices and analyze their strengths and possible changes to these models that could improve their predictive capabilities.
Rangarajan
Rajagopal
R
Department of Biomedical Engineering, The University of Texas at Austin, Austin, Texas 78712, USA.
Zaman
Muhammad H
MH
D002465:Cell Movement; D006801:Humans; D021621:Imaging, Three-Dimensional; D008954:Models, Biological; D009010:Monte Carlo Method