Karl d. Nolph state of the art lecture: feasible and future options for salvation of the peritoneal membrane.
A review is given of the various available strategies that can be used to protect the peritoneal membrane. A discussion of experimental studies on approaches that are still experimental, but that might be applied in patients in the future, follows. The currently available approaches include dietary sodium restriction, use of high-dose loop diuretics and of inhibitors of the renin-angiotensin system. All should preferably be combined with a dialysis prescription aimed at reducing the patient's exposure to glucose and its degradation products. The experimental studies indicate favorable effects of combining osmotic agents, together with drugs that interfere with the polyol pathway and the formation of advanced glycosylation end-products.
Krediet
Raymond T
RT
Division of Nephrology, Department of Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands. C.N.deboer@amc.uva.nl
Coester
Annemieke M
AM
Kolesnyk
Inna
I
de Graaff
Marijke
M
Zweers
Machteld M
MM
Smit
Watske
W
Struijk
Dirk G
DG
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D000818:Animals; D015314:Dialysis Solutions / Q000493:pharmacokinetics / Q000592:standards*; D004232:Diuretics / Q000627:therapeutic use*; D005947:Glucose / Q000493:pharmacokinetics; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006801:Humans; D010530:Peritoneal Dialysis / Q000592:standards*; D010532:Peritoneal Diseases / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D010537:Peritoneum / Q000187:drug effects / Q000378:metabolism*; D017410:Practice Guidelines as Topic
D000806:Angiotensin-Converting Enzyme Inhibitors; D015314:Dialysis Solutions; D004232:Diuretics; D017127:Glycation End Products, Advanced; D005947:Glucose