Malignant melanoma and breast carcinoma: a bidirectional correlation.
BACKGROUND
Epidemiologic and genetic studies have suggested a bidirectional association between breast carcinoma (BC) and malignant melanoma (MM).


METHODS
We present a series of patients with MM and BC detected in our department within a span of 6 months, raising concerns for the high associations between the two malignancies. This led us to match the concordance of the two tumours in the National Irish Cancer Registry.


CONCLUSIONS
The national figures provide evidence of a link between BC and MM. We recommend increased awareness among clinicians leading to more detailed surveillance of both second primary tumours. All MM patients with a family history of BC should be referred to a breast clinic. Women above the age of 40 with MM should undergo annual mammography and those less than 40 may be better evaluated with a breast MRI. All breast cancer patients should be made aware of the significance of changing moles and those with suspicious lesions referred to a dermatologist for evaluation.
Ho
W L
WL
Department of Dermatology, Beaumont Hospital, Dublin 9, Ireland. drwlho@yahoo.com
Comber
H
H
Hill
A D K
AD
Murphy
G M
GM
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015994:Incidence; D007494:Ireland / Q000453:epidemiology; D008545:Melanoma / Q000175:diagnosis / Q000453:epidemiology*; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012042:Registries