Genomic approaches to small molecule discovery.
With the sequencing of the human genome and the development of new genomic technologies, biomedical discovery has been transformed. The applications of these new approaches are ever-expanding from disease classification, to identification of new targets, to outcome prediction. A logical next step is the integration of genomic approaches into small molecule discovery. This review will focus on the application of genomics to compound discovery, with an emphasis on the hematological malignancies. It will focus on the use of genomic tools to discover cancer targets and the development and application of both cell-based and in silico gene expression-based approaches to small molecule discovery.
Stegmaier
K
K
Department of Pediatric Oncology, Dana-Farber Cancer Institute, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. kimberly_stegmaier@dfci.harvard.edu
D055808:Drug Discovery; D015870:Gene Expression; D015894:Genome, Human; D023281:Genomics; D006801:Humans