Strong expression of chemokine receptor CXCR4 by renal cell carcinoma correlates with advanced disease.
Diverse chemokines and their receptors have been associated with tumor growth, tumor dissemination, and local immune escape. In different tumor entities, the level of chemokine receptor CXCR4 expression has been linked with tumor progression and decreased survival. The aim of this study was to evaluate the influence of CXCR4 expression on the progression of human renal cell carcinoma. CXCR4 expression of renal cell carcinoma was assessed by immunohistochemistry in 113 patients. Intensity of CXCR4 expression was correlated with both tumor and patient characteristics. Human renal cell carcinoma revealed variable intensities of CXCR4 expression. Strong CXCR4 expression of renal cell carcinoma was significantly associated with advanced T-status (P = .039), tumor dedifferentiation (P = .0005), and low hemoglobin (P = .039). In summary, strong CXCR4 expression was significantly associated with advanced dedifferentiated renal cell carcinoma.
Wehler
Thomas C
TC
Third Department of Internal Medicine, Johannes Gutenberg University of Mainz, 55131 Mainz, Germany.
Graf
Claudine
C
Biesterfeld
Stefan
S
Brenner
Walburgis
W
Schadt
Jörg
J
Gockel
Ines
I
Berger
Martin R
MR
Thüroff
Joachim W
JW
Galle
Peter R
PR
Moehler
Markus
M
Schimanski
Carl C
CC