title: Transcranial optical monitoring of cerebrovascular hemodynamics in acute stroke patients.
abstract: "Diffuse correlation spectroscopy" (DCS) is a technology for non-invasive transcranial measurement of cerebral blood flow (CBF) that can be hybridized with "near-infrared spectroscopy" (NIRS). Taken together these methods hold potential for monitoring hemodynamics in stroke patients. We explore the utility of DCS and NIRS to measure effects of head-of-bed (HOB) positioning at 30 degrees , 15 degrees , 0 degrees , -5 degrees and 0 degrees angles in patients with acute ischemic stroke affecting frontal cortex and in controls. HOB positioning significantly altered CBF, oxy-hemoglobin (HbO(2)) and total-hemoglobin (THC) concentrations. Moreover, the presence of an ipsilateral infarct was a significant effect for all parameters. Results are consistent with the notion of impaired CBF autoregulation in the infarcted hemisphere.
authors.affiliation: Departments of Radiology, University of Pennsylvania, PA, USA. durduran@alumni.upenn.edu
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Brian L
authors.initials: BL
authors.lastname: Edlow
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Yu
authors.forename: Regine
authors.initials: R
authors.lastname: Choe
authors.forename: Meeri N
authors.initials: MN
authors.lastname: Kim
authors.forename: Brett L
authors.initials: BL
authors.lastname: Cucchiara
authors.forename: Mary E
authors.initials: ME
authors.lastname: Putt
authors.forename: Qaisar
authors.initials: Q
authors.lastname: Shah
authors.forename: Scott E
authors.initials: SE
authors.lastname: Kasner
authors.forename: Joel H
authors.initials: JH
authors.lastname: Greenberg
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
authors.forename: John A
authors.initials: JA
authors.lastname: Detre
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000097:blood / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003943:Diagnostic Techniques, Neurological; D005260:Female; D007839:Functional Laterality; D006454:Hemoglobins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D055620:Optical Phenomena; D010108:Oxyhemoglobins / Q000378:metabolism; D019095:Point-of-Care Systems; D011187:Posture; D019265:Spectroscopy, Near-Infrared / Q000379:methods; D020521:Stroke / Q000097:blood / Q000503:physiopathology*
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin