title: Synthesis and anticonvulsant activity of amino acid-derived sulfamides.
abstract: Sulfamides are promising functions for the design of new antiepileptic drugs ( Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614 ). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
authors.affiliation: Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, 47 and 115, La Plata B1900BJW, Argentina. lgavernet@biol.unlp.edu.ar
authors.forename: Luciana
authors.initials: L
authors.lastname: Gavernet
authors.forename: Juan E
authors.initials: JE
authors.lastname: Elvira
authors.forename: Gisela A
authors.initials: GA
authors.lastname: Samaja
authors.forename: Valentina
authors.initials: V
authors.lastname: Pastore
authors.forename: Mariana Sella
authors.initials: MS
authors.lastname: Cravero
authors.forename: Andrea
authors.initials: A
authors.lastname: Enrique
authors.forename: Guillermina
authors.initials: G
authors.lastname: Estiu
authors.forename: Luis E
authors.initials: LE
authors.lastname: Bruno-Blanch
mesh_terms: D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000927:Anticonvulsants