Isolation and structure of a galactocerebroside from the sea cucumber Bohadschia argus.
A galactocerebroside (BAC-4-4a) was obtained from its parent galactocerebroside molecular species (BAC-4) by using two types of reversed-phase HPLC column. The parent cerebroside BAC-4 has been isolated from less polar lipid fraction of CHCl(3)/MeOH extract of sea cucumber Bohadschia argus, together with known typical types of glucocerebroside molecular species. The structure of BAC-4-4a was determined on the basis of chemical and spectroscopic evidences as 1-O-(beta-D-galactopyranosyl)-(2S,3R,4E)-2[(2'R,15'Z)-2-hydroxytetracosenoylamino]-4-heptadecene-1,3-diol. This is the first report of isolation and structure determination of galactocerebroside from sea cucumber.
Ikeda
Yuriko
Y
Graduate School of Pharmaceutical Sciences, Kyushu University, higashi-ku, Fukuoka 812-8582, Japan.
Inagaki
Masanori
M
Yamada
Koji
K
Zhang
Xiao Wen
XW
Zhang
Bo
B
Miyamoto
Tomofumi
T
Higuchi
Ryuichi
R
D000818:Animals; D005699:Galactosylceramides / Q000737:chemistry* / Q000302:isolation & purification; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D012616:Sea Cucumbers / Q000737:chemistry*
D005699:Galactosylceramides; C002454:galactocerebroside