title: Newly detected glucose disturbance is associated with a high prevalence of diastolic dysfunction: double risk for the development of heart failure?
abstract: Diastolic dysfunction is associated with a high rate of morbidity and mortality and has a high prevalence in patients with diabetes. Aim of the study was to investigate the prevalence of diastolic dysfunction in patients with newly detected glucose metabolism disorder (GMD) submitted for coronary angiography. Oral glucose tolerance test, echocardiography, and tissue Doppler imaging were performed in patients referred to coronary angiography. Prevalence of diastolic dysfunction was 97, 88, and 74% in the known diabetes, newly detected diabetes, and new diagnosed impaired glucose tolerance group, respectively. This is higher than previously reported. Severity of diastolic dysfunction was associated with higher 2-h plasma glucose levels and with new diagnosed diabetes. Screening patients with newly detected GMD for diastolic dysfunction may identify patients with double risk for cardiovascular morbidity and mortality and this group might be a target population to avoid development heart failure.
authors.affiliation: Department of Cardiology, Helios Clinic Wuppertal, Arrenberger Strasse 20, 42117, Wuppertal, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Füth
authors.forename: W
authors.initials: W
authors.lastname: Dinh
authors.forename: L
authors.initials: L
authors.lastname: Bansemir
authors.forename: G
authors.initials: G
authors.lastname: Ziegler
authors.forename: A
authors.initials: A
authors.lastname: Bufe
authors.forename: J
authors.initials: J
authors.lastname: Wolfertz
authors.forename: T
authors.initials: T
authors.lastname: Scheffold
authors.forename: Mark
authors.initials: M
authors.lastname: Lankisch
mesh_terms: D000368:Aged; D001786:Blood Glucose; D003971:Diastole; D005260:Female; D044882:Glucose Metabolism Disorders / Q000150:complications* / Q000175:diagnosis; D005951:Glucose Tolerance Test; D006333:Heart Failure / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012307:Risk Factors
chemical_list: D001786:Blood Glucose