Lanostane-triterpenoids from the fungus Phellinus gilvus.
Triterpenoids gilvsins A-D (1-4), with oxygenated lanostane skeletons, were isolated from the fruiting body of Phellinus gilvus, together with two known compounds, 24-methylenelanost-8-ene-3beta, 22-diol and 5alpha-ergosta-7,22-diene-3-one. The structures of 1-4 were deduced from analysis of spectroscopic data. The absolute configuration at C-22 of 1 was determined by the modified Mosher's method and the structure of 1 was confirmed by X-ray analysis. The hypoglycemic activities of the crude extract of P. gilvus and the isolated compounds were also evaluated, but were not promising for further investigation.
Liu
Hui-Kang
HK
National Research Institute of Chinese Medicine, Taipei, Taiwan.
Tsai
Tung-Hu
TH
Chang
Tun-Tschu
TT
Chou
Cheng-Jen
CJ
Lin
Lie-Chwen
LC
D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D045424:Complex Mixtures / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
D045424:Complex Mixtures; D007004:Hypoglycemic Agents; D014315:Triterpenes; D010729:Phosphoenolpyruvate Carboxykinase (GTP)