Synthesis of isoquinoline derivatives via Ag-catalyzed cyclization of 2-alkynyl benzyl azides.
Ag-catalyzed cyclization of 2-alkynyl benzyl azides offers a novel and efficient method for the synthesis of substituted isoquinoline. The reaction proceeds smoothly in moderate to good yields and tolerates considerable functional groups. The reaction conditions and the scope of the process are examined, and a plausible mechanism is proposed.
Niu
Yan-Ning
YN
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
Yan
Ze-Yi
ZY
Gao
Guo-Lin
GL
Wang
Hong-Li
HL
Shu
Xing-Zhong
XZ
Ji
Ke-Gong
KG
Liang
Yong-Min
YM
D000478:Alkylation; D001386:Azides / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004583:Electrons; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*
D001386:Azides; D007546:Isoquinolines; D012834:Silver; D001554:Benzene; C039109:isoquinoline