title: Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.
abstract: A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).
authors.affiliation: School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
authors.forename: Veemal
authors.initials: V
authors.lastname: Bhowruth
authors.forename: David E
authors.initials: DE
authors.lastname: Minnikin
authors.forename: Else Marie
authors.initials: EM
authors.lastname: Agger
authors.forename: Peter
authors.initials: P
authors.lastname: Andersen
authors.forename: Vincent W
authors.initials: VW
authors.lastname: Bramwell
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Perrie
authors.forename: Gurdyal S
authors.initials: GS
authors.lastname: Besra
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007371:Interferon-gamma / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D000644:Quaternary Ammonium Compounds / Q000276:immunology; D015854:Up-Regulation; D014611:Vaccination
chemical_list: D000276:Adjuvants, Immunologic; D015850:Interleukin-6; D000644:Quaternary Ammonium Compounds; C015831:dimethyldioctadecylammonium; D007371:Interferon-gamma; D005990:Glycerol