title: Assessing depression outcome in patients with moderate dementia: sensitivity of the HoNOS65+ scale.
abstract: To date, there is no widely accepted clinical scale to monitor the evolution of depressive symptoms in demented patients. We assessed the sensitivity to treatment of a validated French version of the Health of the Nation Outcome Scale (HoNOS) 65+ compared to five routinely used scales. Thirty elderly inpatients with ICD-10 diagnosis of dementia and depression were evaluated at admission and discharge using paired t-test. Using the Brief Psychiatric Rating Scale (BPRS) "depressive mood" item as gold standard, a receiver operating characteristic curve (ROC) analysis assessed the validity of HoNOS65+F "depressive symptoms" item score changes. Unlike Geriatric Depression Scale, Mini Mental State Examination and Activities of Daily Living scores, BPRS scores decreased and Global Assessment Functioning Scale score increased significantly from admission to discharge. Amongst HoNOS65+F items, "behavioural disturbance", "depressive symptoms", "activities of daily life" and "drug management" items showed highly significant changes between the first and last day of hospitalization. The ROC analysis revealed that changes in the HoNOS65+F "depressive symptoms" item correctly classified 93% of the cases with good sensitivity (0.95) and specificity (0.88) values. These data suggest that the HoNOS65+F "depressive symptoms" item may provide a valid assessment of the evolution of depressive symptoms in demented patients.
authors.affiliation: Division of Geriatric Psychiatry, Department of Psychiatry, HUG, Belle-Idée, University of Geneva School of Medicine, Geneva, Switzerland.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Canuto
authors.forename: Valérie
authors.initials: V
authors.lastname: Rudhard-Thomazic
authors.forename: François R
authors.initials: FR
authors.lastname: Herrmann
authors.forename: Christophe
authors.initials: C
authors.lastname: Delaloye
authors.forename: Panteleimon
authors.initials: P
authors.lastname: Giannakopoulos
authors.forename: Kerstin
authors.initials: K
authors.lastname: Weber
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003704:Dementia / Q000523:psychology* / Q000628:therapy; D003863:Depression / Q000175:diagnosis* / Q000628:therapy; D003866:Depressive Disorder / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012959:Socioeconomic Factors; D016896:Treatment Outcome