Brazilian natural medicines. III. structures of triterpene oligoglycosides and lipase inhibitors from mate, leaves of ilex paraguariensis.
The methanolic extract from the leaves of Ilex paraguariensis (Aquifoliaceae) was found to show an inhibitory activity on porcine pancreatic lipase. From the methanolic extract, three new triterpene oligoglycosides, mateglycosides A, B, and C, were isolated together with 18 known compounds. The chemical structures of new oligoglycosides were elucidated on the basis of chemical and physicochemical evidence. Several constituents showed inhibitory activities on pancreatic lipase.
Sugimoto
Sachiko
S
Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
Nakamura
Seikou
S
Yamamoto
Sachiyo
S
Yamashita
Chihiro
C
Oda
Yoshimi
Y
Matsuda
Hisashi
H
Yoshikawa
Masayuki
M
D000818:Animals; D001938:Brazil; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry*; D030019:Ilex paraguariensis / Q000737:chemistry*; D008049:Lipase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D013552:Swine; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
D004791:Enzyme Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; D008049:Lipase