title: Serum and BAL cytokine and antioxidant enzyme levels at different stages of pneumoconiosis in coal workers.
abstract: Coal workers' pneumoconiosis (CWP) is an occupational pulmonary disease that occurs by chronic inhalation of coal dust. CWP is divided into two stages depending on the extent of the disease, as simple pneumoconiosis (SP) and progressive massive fibrosis (PMF). In the present study, serum and bronchoalveolar lavage (BAL) cytokine (interleukin-1beta [IL-1beta], IL-6, tumor necrosis factor-alpha [TNF-alpha], transforming growth factor-beta [TGF-beta]) and antioxidant enzymes levels, their relation with the disease severity, and whether they can be considered as biological markers were investigated. Serum and BAL levels of IL-1beta, IL-6, and TNF-alpha were higher in SP and PMF patient groups compared with that in active and retired miner groups. Serum and BAL IL-1beta, IL-6, and TNF-alpha levels were also found to be higher in patients with PMF compared with the SP group. BAL superoxide dismutase (SOD), glutathione peroxidase, and catalase levels and serum SOD level were increased in both patient groups compared with the control group. In addition, mean serum and BAL TGF-beta levels were found to be increased in patients with SP compared with PMF group. Based on these results, BAL and serum cytokine and antioxidant enzymes levels were evaluated and discussed as potential biomarkers for different stages of CWP.
authors.affiliation: Department of Toxicology, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
authors.forename: Oc
authors.initials: O
authors.lastname: Ulker
authors.forename: B
authors.initials: B
authors.lastname: Yucesoy
authors.forename: O
authors.initials: O
authors.lastname: Demir
authors.forename: Io
authors.initials: I
authors.lastname: Tekin
authors.forename: A
authors.initials: A
authors.lastname: Karakaya
mesh_terms: D000368:Aged; D055008:Anthracosis / Q000097:blood / Q000276:immunology / Q000378:metabolism*; D000975:Antioxidants / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000276:immunology; D016022:Case-Control Studies; D002374:Catalase / Q000032:analysis; D003032:Coal Mining; D016207:Cytokines / Q000032:analysis* / Q000097:blood; D018450:Disease Progression; D004798:Enzymes / Q000032:analysis* / Q000097:blood; D005979:Glutathione Peroxidase / Q000032:analysis; D006801:Humans; D053583:Interleukin-1beta / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000032:analysis; D016212:Transforming Growth Factor beta / Q000032:analysis; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016207:Cytokines; D004798:Enzymes; C508600:IL6 protein, human; D053583:Interleukin-1beta; D015850:Interleukin-6; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase