[Studies on the influences of Changan Granule on the model of irritable bowel syndrome rat].
OBJECTIVE
To investigate the influences of Changan Granule on the model of rat with irritable bowel syndrome (IBS) by observing the weight, the content of Nitric Oxide (NO) and 5-hydroxytryptamine (5-HT) in serum of rat.


METHODS
The model of IBS rat was established by decoction of Folium Sennae and restraint stress, effects of Changan Granule were studied through observing the influences on rat weight and the content of NO and 5-HT in serum.


RESULTS
Compared to those of the model group, Changan Granule could improve diarrhea induced by Folium Sennae and increase body weight obviously (P<0.05 or P<0.01). Compared to the control group, Changan Granule could also increase the content of NO and 5-HT in serum significantly (P<0.05 or P<0.01). Through histological survey, we discovered that the high and middle dose of Changan Granule could change the symptom of inflammation and improve the morphous of epithelium mucosae compared to the model group. And there were no obvious pathological changes on the high and middle dose groups of Changan Granule compared to the control group.


CONCLUSIONS
Changan Granule is effective to cure IBS and has protective effects on the bowel mucosae.
Yang
Hai-Yan
HY
Henan Provincial Institute of Food and Drug Control, Zhengzhou 450003, China. myhaiyan2002@yahoo.com.cn
Zhang
Li-Li
LL
Yuan
Xiu-Rong
XR
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects; D043183:Irritable Bowel Syndrome / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D008297:Male; D009569:Nitric Oxide / Q000097:blood*; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012676:Senna Extract / Q000302:isolation & purification; D012701:Serotonin / Q000097:blood*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D009569:Nitric Oxide; D012701:Serotonin; D012676:Senna Extract