title: Image integration-guided catheter ablation of atrial fibrillation: a prospective randomized study.
abstract: BACKGROUND
  Several studies have provided details of left atrial anatomy by means of the image integration techniques, particularly focusing on the atypical patterns of the pulmonary veins.
  
  
  OBJECTIVE
  To compare, in a prospective, randomized fashion, the conventional method of pulmonary vein disconnection and the image integration-guided approach.
  
  
  METHODS
  Two hundred and ninety consecutive patients (290 patients, mean age 55 +/- 11 years) with drug-refractory paroxysmal or persistent atrial fibrillation were enrolled in the study and were divided into two treatment groups: group 1 (145 patients) undergoing an imaging integration-guided (CartoMerge TM) ablation; group 2 (145 patients) treated by a conventional radiofrequency catheter ablation procedure. The arrhythmia was refractory to at least two antiarrhythmic drugs (IC, amiodarone).
  
  
  RESULTS
  Electrical disconnection of all identified pulmonary veins was obtained in all patients of both groups. Bidirectional block of the cavotricuspid isthmus was achieved in 34 group 1 patients and in 40 group 2 patients. Left mitral isthmus ablation was attempted in 52 group 1 patients and in 56 group 2 patients. At a mean follow-up of 14 +/- 12 months, the atrial fibrillation-free survival rate was significantly higher in group 1 patients compared with group 2 patients (88% vs 69%, P = 0.017). The analysis for the subset of patients with previously ineffective ablation (98 patients: 52 group 1 patients and 46 group 2 patients) showed a significantly lower recurrence rate in group 1 versus group 2 (19% vs 48%, P < 0.01).
  
  
  CONCLUSIONS
  Our data indicate a superior efficacy of the image-integration guided catheter ablation of atrial fibrillation over the long term.
authors.affiliation: Centro Cardiologico Monzino, Institute of Cardiology of the University of Milan, Milan, Italy. paolo.dellabella@ccfm.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Della Bella
authors.forename: Gaetano
authors.initials: G
authors.lastname: Fassini
authors.forename: Manuela
authors.initials: M
authors.lastname: Cireddu
authors.forename: Stefania
authors.initials: S
authors.lastname: Riva
authors.forename: Corrado
authors.initials: C
authors.lastname: Carbucicchio
authors.forename: Francesco
authors.initials: F
authors.lastname: Giraldi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Maccabelli
authors.forename: Nicola
authors.initials: N
authors.lastname: Trevisi
authors.forename: Massimo
authors.initials: M
authors.lastname: Moltrasio
authors.forename: Mauro
authors.initials: M
authors.lastname: Pepi
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Galli
authors.forename: Daniele
authors.initials: D
authors.lastname: Andreini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Ballerini
authors.forename: Gianluca
authors.initials: G
authors.lastname: Pontone
mesh_terms: D001281:Atrial Fibrillation / Q000000981:diagnostic imaging* / Q000601:surgery*; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D025321:Surgery, Computer-Assisted / Q000379:methods*; D018511:Systems Integration; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome