A familial case of autoimmune hepatitis.
Autoimmune hepatitis is a chronic liver disease, and both genetic background and environmental factors are related to its pathogenesis. Here, we report that out of five members of a family with similar human leukocyte antigen haplotypes, two developed autoimmune hepatitis, one was positive for antinuclear antibody, and the remaining two had no features of autoimmunity. The two patients with autoimmune hepatitis had a history of medication use, whereas the other family members did not. Our familial study suggests that in addition to genetic background, medication use and other environmental factors may be related to the onset of autoimmune hepatitis.
Yoshida
Osamu
O
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To-on.
Abe
Masanori
M
Furukawa
Shinya
S
Murata
Yosuke
Y
Hamada
Maho
M
Hiasa
Yoichi
Y
Matsuura
Bunzo
B
Akbar
Fazle
F
Michitaka
Kojiro
K
Onji
Morikazu
M
D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D010375:Pedigree
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C493960:HLA-DRB1*04:05 antigen