title: When you are Dishevelled, fat is good and acid is bad!
abstract: Frizzled receptors regulate cell fate decisions and planar cell polarity by means of distinct intracellular effectors. The choice between these two signalling outputs may involve a pH-dependent interaction between Dishevelled and negatively charged lipids at the plasma membrane.
authors.affiliation: Institut Pasteur, CNRS URA2578, 25 rue du Dr Roux, 75015 Paris, France. francois.schweisguth@pasteur.fr
authors.forename: François
authors.initials: F
authors.lastname: Schweisguth
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D016764:Cell Polarity; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology* / Q000378:metabolism*; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D051157:Frizzled Receptors / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D010743:Phospholipids / Q000378:metabolism*; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D015398:Signal Transduction
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D010743:Phospholipids; D010750:Phosphoproteins; C000606588:dsh protein, Drosophila