title: PTK-pathways and TGF-beta signaling pathways in schistosomes.
abstract: Schistosome parasites have co-evolved an intricate relationship with their human and snail hosts as well as a novel interplay between the adult male and female parasites. Drug-induced suppression of female schistosome sexual maturation is an auspicious strategy to combat schistosomiasis since the eggs are the causative agent. Studies on signaling in schistosomes opens a new era for investigation of host-parasite and male-female interactions. We review the role of the TGF-beta signaling pathway in parasite development, host-parasite interactions and male-female interactions. This review also summarizes recent studies suggesting tyrosine kinases as important factors for the regulation of female gonad development. In this context, cytoplasmatic tyrosine kinases of the Src class seem to play especially dominant roles. Moreover, experimental data and theoretical concepts are provided supporting a crosstalk between tyrosine kinase and TGF-beta signaling in the production of vitellocytes. Finally, we take advantage of the schistosome genome project to propose a model for the regulation of vitelline-cell production and differentiation.
authors.affiliation: Department of Pathogenic Organisms, Preclinical Medicine College, Soochow University, Suzhou, China.
authors.forename: Wang
authors.initials: W
authors.lastname: Ting-An
authors.forename: Zhuge
authors.initials: Z
authors.lastname: Hong-Xiang
mesh_terms: D000818:Animals; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006790:Host-Parasite Interactions; D008297:Male; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D012547:Schistosoma / Q000378:metabolism*; D012741:Sexual Maturation; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D016212:Transforming Growth Factor beta; D011505:Protein-Tyrosine Kinases