title: Prevalence and natural history of gastroesophageal reflux: pediatric prospective survey.
abstract: OBJECTIVE
  The prevalence and natural history of gastroesophageal reflux in infants have been poorly documented. The aim of this study was to evaluate the prevalence and natural history of infant regurgitation in Italian children during the first 2 years of life.
  
  
  METHODS
  A detailed questionnaire, according to the Rome II criteria, was completed by 59 primary care pediatricians to assess infant regurgitation in consecutive patients seen in their office over a 3-month period. A total of 2642 patients aged 0 to 12 months were prospectively enrolled during this 3-month period. Follow-up was performed at 6, 12, 18, and 24 months of age.
  
  
  RESULTS
  A total of 313 children (12%; 147 girls) received the diagnosis of infant regurgitation. Vomiting was present in 34 of 313 patients. Their score for the Infant Gastroesophageal Reflux Questionnaire was 8.51 +/- 4.75 (mean +/- SD). Follow-up visits were conducted to the end in 210 of 313 subjects. Regurgitation had disappeared in 56 of 210 infants by the first 6 months of age, in 128 by the first 12 months, in 23 at 18 months, and in 3 patients by the first 24 months. At follow-up, 1 of 210 patients had developed a gastroesophageal reflux disease with esophagitis, proven endoscopically and histologically; another patient received a diagnosis of cow milk protein intolerance. The Infant Gastroesophageal Reflux Questionnaire score reached 0 after 8.2 +/- 3.9 months in breastfed infants (89 of 210) and after 9.6 +/- 4.1 months in artificially fed infants.
  
  
  CONCLUSIONS
  We found that 12% of Italian infants satisfied the Rome II criteria for infant regurgitation. Eighty-eight percent of 210 infants who had completed a 24-month follow-up period had improved at the age of 12 months. Only 1 patient later turned out to have gastroesophageal reflux disease. Use of breast milk was associated with a shorter time necessary to reach an Infant Gastroesophageal Reflux Questionnaire score of 0.
authors.affiliation: University Federico II, Department of Pediatrics, Via S. Pansini 5, 80131 Naples, Italy.
authors.forename: Angelo
authors.initials: A
authors.lastname: Campanozzi
authors.forename: Gabriella
authors.initials: G
authors.lastname: Boccia
authors.forename: Licia
authors.initials: L
authors.lastname: Pensabene
authors.forename: Fabio
authors.initials: F
authors.lastname: Panetta
authors.forename: Antonio
authors.initials: A
authors.lastname: Marseglia
authors.forename: Pietro
authors.initials: P
authors.lastname: Strisciuglio
authors.forename: Cristiana
authors.initials: C
authors.lastname: Barbera
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Magazzù
authors.forename: Massimo
authors.initials: M
authors.lastname: Pettoello-Mantovani
authors.forename: Annamaria
authors.initials: A
authors.lastname: Staiano
mesh_terms: D000367:Age Factors; D001903:Bottle Feeding / Q000706:statistics & numerical data; D001942:Breast Feeding / Q000706:statistics & numerical data; D003430:Cross-Sectional Studies; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000453:epidemiology; D004945:Esophagoscopy; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology*; D006306:Health Surveys; D006801:Humans; D007223:Infant; D007558:Italy; D008297:Male; D011446:Prospective Studies