Identification of nobiletin, a polymethoxyflavonoid, as an enhancer of adiponectin secretion.
Adiponectin, an adipocyte-derived protein with insulin-sensitizing, anti-diabetic and anti-atherogenic activities, is known to be induced during adipocyte differentiation. Nobiletin, a citrus polymethoxy flavonoid, was found to induce the differentiation of ST-13 preadipocytes into mature adipocytes and enhance the production of adiponectin protein at a concentration of 10 microM.
Kunimasa
Kazuhiro
K
Laboratory of Cell and Molecular Biology of Aging, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, Shizuoka 422-8526, Japan.
Kuranuki
Sachi
S
Matsuura
Nobuyasu
N
Iwasaki
Nozomi
N
Ikeda
Megumi
M
Ito
Akira
A
Sashida
Yutaka
Y
Mimaki
Yoshihiro
Y
Yano
Masamichi
M
Sato
Mayumi
M
Igarashi
Yasuhiro
Y
Oikawa
Tsutomu
T
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D052242:Adiponectin / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D011416:Complement Factor D / Q000378:metabolism; D050556:Fatty Acid-Binding Proteins / Q000378:metabolism; D047309:Flavones / Q000737:chemistry / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D047495:PPAR gamma / Q000819:agonists; D015854:Up-Regulation
D052242:Adiponectin; C493411:Fabp4 protein, mouse; D050556:Fatty Acid-Binding Proteins; D047309:Flavones; D005419:Flavonoids; D047495:PPAR gamma; C008661:nobiletin; D011416:Complement Factor D