Prenatal diagnosis of transient abnormal myelopoiesis in a Down syndrome fetus.
We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28(+3) weeks of gestation that rapidly progressed to intrauterine death 10 days later. Fetal hepatosplenomegaly with cerebral ventriculomegaly, although not specific, may be a suggestive finding of Down syndrome with transient abnormal myelopoiesis. Prompt fetal blood sampling for liver function test and chromosomal analysis are mandatory for early detection and management.
Kim
Gwang Jun
GJ
Department of Obstetric and Gynecology, Chung-Ang University School of Medicine, Seoul, Korea.
Lee
Eun Sil
ES
D000328:Adult; D004314:Down Syndrome / Q000000981:diagnostic imaging*; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005313:Fetal Death; D005315:Fetal Diseases / Q000175:diagnosis*; D006529:Hepatomegaly / Q000000981:diagnostic imaging; D006801:Humans; D007964:Leukocytosis / Q000175:diagnosis; D038042:Myelopoiesis; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013163:Splenomegaly / Q000000981:diagnostic imaging; D013921:Thrombocytopenia / Q000175:diagnosis; D014463:Ultrasonography