Urinary protein assessment in preeclampsia: which sample is more suitable?
Mild or severe preeclampsia is responsible for about 70% of hypertensive disorders observed during pregnancy and 24 h urine collection is a gold standard for diagnosis ofpreeclampsia. This study was performed to determine whether the gold standard of 24 h urine protein value in pre-eclampsia can be substituted with 8 or 12 h urine protein values and to evaluate the effect of ambulation and immobilization on amount of protein excretion. A cross sectional study was conducted on 40 women with pre-eclampsia (BP > or = 140/90 mmHg), who referred to the Department of Obstetric and Gynecology, Imam Khomeiny hospital in Sari, Iran from April 2005 to September 2005. Positive urinary strip for protein of at least 1+ samples were collected over 24 h in subsequent periods: the first 8 h and the next 4 h and remaining 12 h urine, in separate containers. The correlation between groups was determined by Pearson's correlation. A total of 40 women were recurited in this study of which 36 had completed urine collection. A total of 21 had mild proteinuria, 5 had severe proteinuria and 10 had no proteinuria. There was significant correlation between the 8 or 12 h (day) and 12 h (night) with 24 h urine protein. Total protein values of 8 and 12 h (day) and 12 h (night) samples, positively correlated with values of 24 h samples in pre-eclampsia and could be substituted for assessment of proteinuria instead of 24 h urine collection in women with pre-eclampsia, as a simpler, faster and cheaper method for diagnosis of pre-eclampsia. And ambulation and immobilization in preeclamptic patients has not any effect on protein excretion.
Moslemizadeh
N
N
Department of Obstetric and Gynecology, Imam Khomeini Hospital, Amir-Mazandarani Boulevard, P.O. Box 48166-33131, Sari, Iran.
Yousefnejad
K
K
Moghadam
T Galini
TG
Peyvandi
S
S
D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000175:diagnosis* / Q000652:urine*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011507:Proteinuria / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D013997:Time Factors; D016482:Urinalysis / Q000379:methods*