title: Oligomerization of the heptahelical G protein coupling receptors: a case for association using transmembrane helices.
abstract: The heptahelical G protein coupling receptors oligomerize extensively via transmembrane domains, in association with heterotrimeric G proteins. This provides higher affinity for agonists, conformational stability necessary for signal transduction, and protection from intracellular proteinases. The oligomerization is relevant to organismic pathophysiology and could be targeted by natural or modified agonists.
authors.affiliation: Department of Molecular Cell Sciences, University of Memphis, Memphis, TN 38163, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Parker
authors.forename: R
authors.initials: R
authors.lastname: Sah
authors.forename: E A
authors.initials: EA
authors.lastname: Park
authors.forename: T
authors.initials: T
authors.lastname: Sweatman
authors.forename: A
authors.initials: A
authors.lastname: Balasubramaniam
authors.forename: F R
authors.initials: FR
authors.lastname: Sallee
authors.forename: S L
authors.initials: SL
authors.lastname: Parker
mesh_terms: D000818:Animals; D006801:Humans; D054730:Protein Interaction Domains and Motifs / Q000502:physiology; D055503:Protein Multimerization; D020836:Protein Structure, Quaternary; D021122:Protein Subunits / Q000737:chemistry / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000737:chemistry* / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D021122:Protein Subunits; D043562:Receptors, G-Protein-Coupled