title: Prenylation of flavonoids by biotransformation of yeast expressing plant membrane-bound prenyltransferase SfN8DT-1.
abstract: Prenylated flavonoids are natural products that exhibit diverse biological effects and often represent the active components of various medicinal plants. This study demonstrated the production of prenylated naringenin by biotransformation using transgenic yeast expressing naringenin 8-dimethylallyltransferase, a membrane-bound enzyme, without feeding of prenyl donors. This method provides the possibility of generating prenylated flavonoids that occur rarely in nature.
authors.affiliation: Laboratory of Plant Gene Expression, Research Institute for Sustainable Humanosphere, Kyoto University, Gokasho, Uji, Japan.
authors.forename: Kanako
authors.initials: K
authors.lastname: Sasaki
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tsurumaru
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Yazaki
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D004122:Dimethylallyltranstransferase / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D005419:Flavonoids / Q000378:metabolism*; D054876:Prenylation; D029909:Sophora / Q000166:cytology* / Q000201:enzymology*; D015003:Yeasts / Q000235:genetics*
chemical_list: D005419:Flavonoids; D004122:Dimethylallyltranstransferase