[Effect of equol of a isoflavone metabolite on menopausal symptoms].
OBJECTIVE
To explore the effect of equol of a isoflavone metabolite on menopausal women and the menopausal syndrome.


METHODS
71 menopausal women living in Harbin were assessed, and the participants were at the age of 45-55 years. The concentrations of Isoflavone and equol in first-void morning urines were analyzed by HPLC. All participants completed Kupperman questionnaire tables which were used to evaluate the severity of menopausal symptoms. The association between the equol concentrations in menopausal women and the menopausal syndrome were examine by statistical analysis method.


RESULTS
The negative association between the urinary equol concentrations and the menopausal index score (P < 0.05) were found, and the negative correlation only exists in EP group after grouping at the concentration of 0.5 microg/ml equol.


CONCLUSIONS
It was suggested that it were more higher of urinary equol concentration in menopausal women, more less of the menopausal symptoms.
Wang
Lu
L
Department of Food Science and Engineering, Harbin Institute of Technology, Harbin 150090, China. wanglu-tianfeng@yahoo.com.cn
Zhao
Haitian
H
Cheng
Cuilin
C
Xie
Fangqin
F
D060754:Equol; D005260:Female; D019584:Hot Flashes / Q000517:prevention & control*; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D008593:Menopause / Q000187:drug effects* / Q000378:metabolism; D008875:Middle Aged; D048789:Phytoestrogens / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D030262:Soybean Proteins / Q000008:administration & dosage*; D011795:Surveys and Questionnaires; D013577:Syndrome
C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D007529:Isoflavones; D048789:Phytoestrogens; D030262:Soybean Proteins; D060754:Equol