title: Transcatheter arterial embolization therapy for a massive polycystic liver in autosomal dominant polycystic kidney disease patients.
abstract: Polycystic liver is the most common extra-renal manifestation associated with autosomal dominant polycystic kidney disease (ADPKD), comprising up to 80% of all features. Patients with polycystic liver often suffer from abdominal discomfort, dyspepsia, or dyspnea; however, there have been few ways to relieve their symptoms effectively and safely. Therefore, we tried transcatheter arterial embolization (TAE), which has been used in treating hepatocellular carcinoma. We enrolled four patients with ADPKD in Seoul National University Hospital, suffering from enlarged polycystic liver. We embolized the hepatic arteries supplying the dominant hepatic segments replaced by cysts using polyvinyl alcohol particles and micro-coils. The patients were evaluated 12 months after embolization for the change in both liver and cyst volumes. Among four patients, one patient was lost in follow up and 3 patients were included in the analysis. Both liver (33%; 10%) and cyst volume (47.7%; 11.4%) substantially decreased in two patients. Common adverse events were fever, epigastric pain, nausea, and vomiting. We suggest that TAE is effective and safe in treating symptomatic polycystic liver in selected ADPKD patients.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Hayne Cho
authors.initials: HC
authors.lastname: Park
authors.forename: Chi Weon
authors.initials: CW
authors.lastname: Kim
authors.forename: Han
authors.initials: H
authors.lastname: Ro
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Moon
authors.forename: Kook-Hwan
authors.initials: KH
authors.lastname: Oh
authors.forename: Yonsu
authors.initials: Y
authors.lastname: Kim
authors.forename: Jung Sang
authors.initials: JS
authors.lastname: Lee
authors.forename: Yong Hu
authors.initials: YH
authors.lastname: Yin
authors.forename: Hwan Jun
authors.initials: HJ
authors.lastname: Jae
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Chung
authors.forename: Curie
authors.initials: C
authors.lastname: Ahn
authors.forename: Young-Hwan
authors.initials: YH
authors.lastname: Hwang
mesh_terms: D000368:Aged; D002404:Catheterization; D003560:Cysts / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D008099:Liver / Q000473:pathology / Q000502:physiology; D008107:Liver Diseases / Q000473:pathology / Q000628:therapy*; D008875:Middle Aged; D016891:Polycystic Kidney, Autosomal Dominant / Q000175:diagnosis / Q000628:therapy*; D011142:Polyvinyl Alcohol / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D011142:Polyvinyl Alcohol