Monitoring strontium ranelate therapy in patients with osteoporosis.
OBJECTIVE
The purpose of this study was to review the monitoring of strontium ranelate osteoporosis therapy.


METHODS
The method used in this study was comprehensive literature review with clinical perspectives.


RESULTS
Changes in bone turnover markers (BTM) or bone mineral density (BMD) have been documented in osteoporosis clinical trials. However, neither BMD nor BTM changes fully explain the observed fracture risk reduction in treated patients. If changes in BMD or BTM on therapy would be easily discernable in individual patients, and were strongly associated with fracture risk reduction, monitoring individuals would be more useful. BMD changes in patients on strontium ranelate are of a greater magnitude and hence can be easily determined in an individual patient. In addition, there exists a better correlation between fracture risk reduction and increases in BMD.


CONCLUSIONS
The strong correlation between measured BMD increases and fracture risk reduction in patients on strontium ranelate therapy will be of clinical benefit to physicians wishing to evaluate both treatment persistence and fracture risk reduction.
Kendler
D L
DL
University of British Columbia, Vancouver, BC, Canada. kendler@ca.inter.net
Adachi
J D
JD
Josse
R G
RG
Slosman
D O
DO
D015415:Biomarkers / Q000378:metabolism; D015519:Bone Density / Q000187:drug effects*; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D016723:Bone Remodeling; D002986:Clinical Trials as Topic; D050723:Fractures, Bone / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D009942:Organometallic Compounds / Q000627:therapeutic use*; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome
D015415:Biomarkers; D050071:Bone Density Conservation Agents; D009942:Organometallic Compounds; D013876:Thiophenes; C081587:strontium ranelate