title: Analysis of the transforming growth factor beta1 gene -509 C/T polymorphism in patients with advanced-stage endometriosis.
abstract: OBJECTIVE
  To investigate whether the transforming growth factor beta (TGF-beta) gene -509 C/T polymorphism is associated with susceptibility to advanced-stage endometriosis.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  University department of obstetrics and gynecology.
  
  
  METHODS
  Women with advanced-stage endometriosis (n = 485) and without endometriosis (n = 352).
  
  
  METHODS
  Genotyping by real-time polymerase chain reaction using a Taqman assay.
  
  
  METHODS
  Genotype distribution and allele frequency of the -509 C/T polymorphism in the TGF-beta1 gene.
  
  
  RESULTS
  The genotype distribution of the TGF-beta1 gene -509 C/T polymorphism in the endometriosis group was not different from that of the control group (CC/CT/TT rates were 29.3%/48.2%/22.5% and 27.3%/50.3%/22.4% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometrioma also revealed no significant differences in the genotype distribution between each of the subgroups and the control group.
  
  
  CONCLUSIONS
  These results suggest that the TGF-beta1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Seon Ha
authors.initials: SH
authors.lastname: Choung
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Yoon
authors.forename: Kyu Sup
authors.initials: KS
authors.lastname: Lee
authors.forename: Seung Yup
authors.initials: SY
authors.lastname: Ku
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D018450:Disease Progression; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1