title: [Age-related macular degeneration (AMD)].
abstract: Today age-related macular degeneration (AMD) is the most frequent cause for legal blindness in western industrialized countries. The prevalence of this disease rises with increasing age. A multifactorial pathogenesis of AMD is postulated including genetic predisposition and environmental risk factors. The most relevant modifiable risk factor is smoking. Up to today there is no cure of this chronic disease. Prophylaxis, including a healthy diet and antioxidants as nutrional supplements for selected patients, aims to slow down the disease progression. Significant progress has been made in the treatment of the neovascular form of the disease using inhibitors of the vascular endothelial growth factor (VEGF).
authors.affiliation: Augenklinik, Universitätsspital Zürich. stephan.michels@usz.ch
authors.forename: Stephan
authors.initials: S
authors.lastname: Michels
authors.forename: Malaika
authors.initials: M
authors.lastname: Kurz-Levin
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use; D052157:Aptamers, Nucleotide / Q000627:therapeutic use; D004032:Diet; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D020022:Genetic Predisposition to Disease; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000235:genetics / Q000517:prevention & control; D008875:Middle Aged; D010778:Photochemotherapy; D011110:Polymorphism, Genetic; D015995:Prevalence; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors; D014792:Visual Acuity; D015032:Zinc / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D052157:Aptamers, Nucleotide; D042461:Vascular Endothelial Growth Factor A; C495058:pegaptanib; D015032:Zinc