title: [Estrogens and pharmacological modulation of estrogen receptors].
abstract: Estrogens belong to more or less frequently prescribed preparations. Main fields of application of these preparations (as in monotherapy as well as in combination) are contraception and hormone replacement therapy during menopause. More uncommon indications of estrogens are growth inhibition and hypogonadism (in this case they are prescribed along with gonadotropic hormones). Synthesis and metabolism of estrogens, as well as their intracellular receptors are well studied these days, which allow us to understand physiology and pharmacology of these hormones. In pharmacology the main stage is detection of estrogen receptors inside of cells of targets. There are two types of estrogen receptors alpha- and beta- coded by different genes. A number of steroid and non-steroid compounds have characteristics of estrogens. Likely in the future their popularity will increase, as by the aging of population number of those women, who receive replacement therapy, will increase. Investigations to find an ideal elective modulator of estrogen receptors, that will possess anti-estrogenic activity in connection with mammal gland and develop indifference in connection with endometrium and at the same time will display ability to reduce hot flushes, bone resorption, atrophy of mucous membranes of vagina and urinary bladder, as well as it will favorably effect on metabolism of lipoproteins are carried out.
authors.forename: T V
authors.initials: TV
authors.lastname: Sanidize
authors.forename: L R
authors.initials: LR
authors.lastname: Ratiani
authors.forename: L Iu
authors.initials: LIu
authors.lastname: Gabuniia
authors.forename: M L
authors.initials: ML
authors.lastname: Tortladze
authors.forename: N N
authors.initials: NN
authors.lastname: Kuridze
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy; D004965:Estrogen Antagonists / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D011960:Receptors, Estrogen / Q000037:antagonists & inhibitors*; D013629:Tamoxifen / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D004965:Estrogen Antagonists; D004967:Estrogens; D011960:Receptors, Estrogen; D013629:Tamoxifen