A second E2 for nedd8ylation expands substrate selection.
The ubiquitin-like modifier NEDD8 promotes substrate ubiquitination via its covalent linkage to ubiquitin cullin-RING ligases. This depends on a NEDD8-specific sequential enzymatic cascade of E1, E2, and E3 enzymes. The identification of a second E2 enzyme for nedd8ylation recently reported in Molecular Cell (Huang et al., 2009) reveals novel insights into the molecular mechanism of target cullin selection.
Pichler
Andrea
A
D001665:Binding Sites; D044842:Cullin Proteins / Q000378:metabolism; D013379:Substrate Specificity; D044763:Ubiquitin-Conjugating Enzymes / Q000378:metabolism*; D054875:Ubiquitination; D014452:Ubiquitins / Q000378:metabolism*
D044842:Cullin Proteins; D014452:Ubiquitins; D044763:Ubiquitin-Conjugating Enzymes