Visualization of 3-D high speed ultrahigh resolution optical coherence tomographic data identifies structures visible in 2D frames.
Optical coherence tomography has allowed unprecedented visualization of ocular structures, but the identity of some visible objects within slices remains unknown. This study reconstructs a number of those objects in 3D space, allowing their identification by observation of their 3D morphology. In the case mottling deep within image slices through the optic disc, C-mode imaging provided visualization of the appearance and distribution of laminar pores. In the case of white spots and streaks sometimes observed in image slices through the cornea, C-mode imaging contoured to the path of those white spots allowed their visual identification as nerves extending radially into the cornea from the limbus. White spots observed in ultra-high resolution retinal image slices were identified as blood within retinal capillaries. C-mode contour-corrected imaging of three dimensional structures provided the identification of previously unidentified structures visible in cross-sectional image slices.
Kagemann
Larry
L
UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Ishikawa
Hiroshi
H
Wollstein
Gadi
G
Gabriele
Michelle
M
Schuman
Joel S
JS
D003315:Cornea / Q000033:anatomy & histology; D016208:Databases, Factual; D005123:Eye / Q000033:anatomy & histology*; D005451:Fluorescein Angiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D008266:Macula Lutea / Q000033:anatomy & histology; D009898:Optic Disk / Q000033:anatomy & histology; D009900:Optic Nerve / Q000033:anatomy & histology; D012160:Retina / Q000033:anatomy & histology; D012171:Retinal Vessels / Q000033:anatomy & histology; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000706:statistics & numerical data