title: Uterine cervical carcinosarcoma with heterologous mesenchymal component: a case report and review of the literature.
abstract: BACKGROUND
  Carcinosarcomas of the uterine cervix are very rare. Most of them have a homologous mesenchymal component, and cervical carcinosarcomas with a heterologous mesenchymal component are limited to nine cases.
  
  
  METHODS
  A 61-year-old Japanese woman was admitted to the hospital for treatment of a ureteral stone. Imaging studies detected an indistinct cervical mass. A histopathological diagnosis of the cervical biopsy was a carcinosarcoma. A total abdominal hysterectomy with bilateral salpingo-oophorectomy and pelvic lymphadenectomy was carried out upon a diagnosis of stage Ib1 cervical carcinosarcoma. Microscopically, the cervical mass revealed a carcinosarcoma consisting of endometrioid adenocarcinoma and chondrosarcoma. Immunohistochemically, p53 was positive in the epithelial and mesenchymal components. Postoperatively, the patient underwent radiation and chemotherapy. She is alive with no evidence of recurrence 5 years and 10 months after the operation.
  
  
  CONCLUSIONS
  We suppose that the similar proportion of p53 overexpression in both the epithelial and mesenchymal components may be one of the findings explaining the histogenesis of this tumor by combination theory.
authors.affiliation: Department of Diagnostic Pathology, Faculty of Medicine, University Hospital, Kagawa University, 1750-1, Ikenobe, Miki-cho, Kagawa 761-0793, Japan. qichi@med.kagawa-u.ac.jp
authors.forename: Kyuichi
authors.initials: K
authors.lastname: Kadota
authors.forename: Reiji
authors.initials: R
authors.lastname: Haba
authors.forename: Masashi
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kushida
authors.forename: Naomi
authors.initials: N
authors.lastname: Katsuki
authors.forename: Toshitetsu
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yumi
authors.initials: Y
authors.lastname: Miyai
authors.forename: Kenji
authors.initials: K
authors.lastname: Bando
authors.forename: Atsuko
authors.initials: A
authors.lastname: Shiota
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Hata
mesh_terms: D001706:Biopsy; D002296:Carcinosarcoma / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007150:Immunohistochemistry; D008875:Middle Aged; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery*