title: [Do isolated hypertension and metabolic syndrome have equal risk of stroke in Chinese adults?].
abstract: OBJECTIVE
  To analyze whether isolated hypertension and metabolic syndrome ( Based on the 2005 IDF criteria) have equal risk on stroke in Chinese adults.
  
  
  METHODS
  25194 subjects (25-75 years old) from Chinese National Health and Nutrition Survey in 2002 were divided into control group, isolated hypertension ( i-HTN) group, metabolic syndrome (MS) without hypertension ( non-HTN/MS) group , MS with hypertension (HTN/MS) group. The clinical features and risk for stroke ( using multiple logistic stepwise regression analysis) were compared among 4 groups.
  
  
  RESULTS
  (1) The clinic features in the i-HTN group was non-central obesity, and its plasma glucose, triglyceride 9TG), high density lipoprotein cholesterol ( HDL-C) levels were normal . (2) The prevalence of stroke in control group , i-HTN group, non-HTN/MS group and HTN/MS group was 0.14%, 1.27%, 1.19% and 2.14%, respectively. (3) After adjustment for age, sex, smoking, low density lipoprotein cholesterol level, logistic regression analysis showed that the i-HTN group, non-HTN/MS group and HTN/MS group had higher risk of stroke compared with the controls, the odd ratio (OR) were 4.18, 8.00, 8.69 (P < 0.01), respectively. Compared with i-HTN group, OR in HTN/MS group was 2.05, while no difference was found between i-HTN group and non-HTN/MS group ( P>0.05). (4) Among different components of the MS, hypertension (OR 2.33), central obesity (OR 2.09), low HDL-C (OR 1.69), hyperglycemia (OR 1.66) except hypertriglyceridemia were all significantly related to stroke (P < 0.01).
  
  
  CONCLUSIONS
  (1) MS and hypertension were an independent risk factor for the development of stroke in Chinese adults. (2) Though there was no clinical features of insulin resistance in i-HTN group, it was observed that the i-HTN and non-HTN/MS had equal contribution to stroke. The risk of stroke will be further increased if hypertension included in the MS.
authors.affiliation: Center of Endocrinology and Metabolism, China-Japan Friendship Hospital, Beijing, China.
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Xing
authors.forename: Guang-wei
authors.initials: GW
authors.lastname: Li
authors.forename: Chong-hua
authors.initials: CH
authors.lastname: Yao
authors.forename: Yi-song
authors.initials: YS
authors.lastname: Hu
authors.forename: Feng-ying
authors.initials: FY
authors.lastname: Zhai
authors.forename: Ke-qin
authors.initials: KQ
authors.lastname: Rao
authors.forename: Ling-zhi
authors.initials: LZ
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002681:China / Q000453:epidemiology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology*; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D012307:Risk Factors; D020521:Stroke / Q000453:epidemiology* / Q000209:etiology