title: Longitudinal assessments of quality of life in endometrial cancer patients: effect of surgical approach and adjuvant radiotherapy.
abstract: OBJECTIVE
  Adjuvant radiotherapy (RT) is often considered for endometrial cancer. We studied the effect of RT and surgical treatment on patients' quality of life (QOL).
  
  
  METHODS
  All patients referred to the gynecologic oncology clinics with biopsy findings showing endometrial cancer were recruited. QOL assessments were performed using the European Organization for Research and Treatment of Cancer QOL questionnaire-C30, version 3. Assessments were obtained at study entry and at regular 3-month intervals for a maximum of 2 years. Open-ended telephone interviews were done every 6 months. Linear mixed regression models were built using QOL domain scores as dependent variables, with the predictors of surgical treatment and adjuvant RT type.
  
  
  RESULTS
  A total of 40 patients were recruited; 80% of the surgeries were performed by laparotomy. Significant improvements were seen in most QOL domains with increased time from treatment. Adjuvant RT resulted in significantly more severe bowel symptoms and improvement in insomnia compared with conservative follow-up. No significant adverse effect from adjuvant RT was seen on the overall QOL. Bowel symptoms were significantly increased in patients treated with laparotomy compared with laparoscopy in the patients treated with whole pelvic RT. Qualitatively, about one-half of the patients noted improvements in their overall QOL during follow-up, with easy fatigability the most prevalent.
  
  
  CONCLUSIONS
  No significant adverse effect was seen on patients' overall QOL with adjuvant pelvic RT after the recovery period. The acute adverse effects on patients' QOL significantly improved with an increasing interval from diagnosis.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Ottawa, 501 Smyth Road, Ottawa, Ontario, Canada. tle@ottawahospital.on.ca
authors.forename: Tien
authors.initials: T
authors.lastname: Le
authors.forename: Chantal
authors.initials: C
authors.lastname: Menard
authors.forename: Rajiv
authors.initials: R
authors.lastname: Samant
authors.forename: E
authors.initials: E
authors.lastname: Choan
authors.forename: Laura
authors.initials: L
authors.lastname: Hopkins
authors.forename: Wylam
authors.initials: W
authors.lastname: Faught
authors.forename: Michael
authors.initials: M
authors.lastname: Fung-Kee-Fung
mesh_terms: D016889:Endometrial Neoplasms / Q000150:complications / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects; D007813:Laparotomy / Q000009:adverse effects; D008137:Longitudinal Studies; D008875:Middle Aged; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D014592:Uterine Hemorrhage / Q000209:etiology