title: The ratio of NR2A/B NMDA receptor subunits determines the qualities of ocular dominance plasticity in visual cortex.
abstract: Bidirectional synaptic plasticity during development ensures that appropriate synapses in the brain are strengthened and maintained while inappropriate connections are weakened and eliminated. This plasticity is well illustrated in mouse visual cortex, where monocular deprivation during early postnatal development leads to a rapid depression of inputs from the deprived eye and a delayed strengthening of inputs from the non-deprived eye. The mechanisms that control these bidirectional synaptic modifications remain controversial. Here we demonstrate, both in vitro and in vivo, that genetic deletion or reduction of the NR2A NMDA receptor subunit impairs activity-dependent weakening of synapses and enhances the strengthening of synapses. Although brief monocular deprivation in juvenile WT mice normally causes a profound depression of the deprived-eye response without a change in the non-deprived eye response, NR2A-knockout mice fail to exhibit deprivation-induced depression and instead exhibit precocious potentiation of the non-deprived eye inputs. These data support the hypothesis that a reduction in the NR2A/B ratio during monocular deprivation is permissive for the compensatory potentiation of non-deprived inputs.
authors.affiliation: Picower Institute for Learning and Memory, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors.forename: Kathleen K A
authors.initials: KK
authors.lastname: Cho
authors.forename: Lena
authors.initials: L
authors.lastname: Khibnik
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Philpot
authors.forename: Mark F
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000818:Animals; D023882:Dominance, Ocular; D051379:Mice; D018345:Mice, Knockout; D009473:Neuronal Plasticity; D016194:Receptors, N-Methyl-D-Aspartate / Q000032:analysis*; D015349:Vision, Monocular; D014793:Visual Cortex
chemical_list: C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate