title: Bladder cancer SNP panel predicts susceptibility and survival.
abstract: Bladder cancer is the fourth most common malignancy in men and the eighth most common in women in western countries. Single nucleotide polymorphisms (SNPs) in genes that regulate telomere maintenance, mitosis, inflammation, and apoptosis have not been assessed extensively for this disease. Using a population-based study with 832 bladder cancer cases and 1,191 controls, we assessed genetic variation in relation to cancer susceptibility or survival. Findings included an increased risk associated with variants in the methyl-metabolism gene, MTHFD2 (OR 1.7 95% CI 1.3-2.3), the telomerase TEP1 (OR 1.8 95% CI 1.2-2.6) and decreased risk associated with the inflammatory response gene variant IL8RB (OR 0.6 95% CI 0.5-0.9) compared to wild-type. Shorter survival was associated with apoptotic gene variants, including CASP9 (HR 1.8 95% CI 1.1-3.0). Variants in the detoxification gene EPHX1 experienced longer survival (HR 0.4 (95% CI 0.2-0.8). These genes can now be assessed in multiple study populations to identify and validate SNPs appropriate for clinical use.
authors.affiliation: Section of Biostatistics and Epidemiology, Department of Community and Family Medicine, Dartmouth Medical School, Lebanon, NH 03756, USA. Angeline.Andrew@dartmouth.edu
authors.forename: Angeline S
authors.initials: AS
authors.lastname: Andrew
authors.forename: Jiang
authors.initials: J
authors.lastname: Gui
authors.forename: Arthur C
authors.initials: AC
authors.lastname: Sanderson
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Mason
authors.forename: Elaine V
authors.initials: EV
authors.lastname: Morlock
authors.forename: Alan R
authors.initials: AR
authors.lastname: Schned
authors.forename: Karl T
authors.initials: KT
authors.lastname: Kelsey
authors.forename: Carmen J
authors.initials: CJ
authors.lastname: Marsit
authors.forename: Jason H
authors.initials: JH
authors.lastname: Moore
authors.forename: Margaret R
authors.initials: MR
authors.lastname: Karagas
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D017720:Molecular Epidemiology; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D001749:Urinary Bladder Neoplasms / Q000235:genetics* / Q000401:mortality
chemical_list: D004273:DNA, Neoplasm