title: Synthesis of isoquinoline derivatives via Ag-catalyzed cyclization of 2-alkynyl benzyl azides.
abstract: Ag-catalyzed cyclization of 2-alkynyl benzyl azides offers a novel and efficient method for the synthesis of substituted isoquinoline. The reaction proceeds smoothly in moderate to good yields and tolerates considerable functional groups. The reaction conditions and the scope of the process are examined, and a plausible mechanism is proposed.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Yan-Ning
authors.initials: YN
authors.lastname: Niu
authors.forename: Ze-Yi
authors.initials: ZY
authors.lastname: Yan
authors.forename: Guo-Lin
authors.initials: GL
authors.lastname: Gao
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Shu
authors.forename: Ke-Gong
authors.initials: KG
authors.lastname: Ji
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000478:Alkylation; D001386:Azides / Q000737:chemistry*; D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D004583:Electrons; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012834:Silver / Q000737:chemistry*
chemical_list: D001386:Azides; D007546:Isoquinolines; D012834:Silver; D001554:Benzene; C039109:isoquinoline