Ecdysteroids and a sucrose phenylpropanoid ester from Froelichia floridana.
Phytoecdysteroid glycosides (1-5) and a phenylpropanoid ester of sucrose (6) were isolated from the whole plant of Froelichia floridana, along with eight known compounds including three ecdysteroids (7-9), four flavonoids (10-13), and one phenolic compound (14). Structures were determined using a combination of spectroscopic techniques. Compounds 1, 2 and 6-14 were tested in vitro for their activity against human DNA topoisomerase I. Compound 13 (diosmetin) showed marginal inhibition against topoisomerase I with IC(50) of 130 microM in conjunction with low intercalation ability.
Wang
Ping
P
National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962, USA.
Li
Shiyou
S
Ownby
Stacy
S
Zhang
Zhizhen
Z
Yuan
Wei
W
Zhang
Wanli
W
Scott Beasley
R
R
D027703:Amaranthaceae / Q000737:chemistry*; D026461:Ecdysteroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors
D026461:Ecdysteroids; D004952:Esters; D005419:Flavonoids; D010636:Phenols; D059004:Topoisomerase I Inhibitors