title: Short report: Development of post-kala-azar dermal leishmaniasis (PKDL) in miltefosine-treated visceral leishmaniasis.
abstract: We report two cases of post-kala-azar dermal leishmaniasis (PKDL), which had subsequently developed after successful treatment of visceral leishmaniasis with miltefosine. Both patients had maculo-nodular lesions all over the body, and they were diagnosed as PKDL by parasitologic examination for Leishmania donovani bodies in a skin snip of lesions. Patients were put on amphotericin B and responded very well for nodular lesions with one course of treatment. However, longer duration of the treatment is needed for total clearance of macular lesions from body surface in PKDL cases. This is the first case report of PKDL in India, which developed after successful treatment of visceral leishmaniasis with miltefosine.
authors.affiliation: Division of Clinical Medicine, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India. drkrishnapandey@yahoo.com
authors.forename: Vidya Nand Rabi
authors.initials: VN
authors.lastname: Das
authors.forename: Krishna
authors.initials: K
authors.lastname: Pandey
authors.forename: Neena
authors.initials: N
authors.lastname: Verma
authors.forename: Chandra Shekhar
authors.initials: CS
authors.lastname: Lal
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Bimal
authors.forename: Roshan Kamal
authors.initials: RK
authors.lastname: Topno
authors.forename: Dharmendra
authors.initials: D
authors.lastname: Singh
authors.forename: Niyamat Ali
authors.initials: NA
authors.lastname: Siddiqui
authors.forename: Rakesh Bihari
authors.initials: RB
authors.lastname: Verma
authors.forename: Pradeep
authors.initials: P
authors.lastname: Das
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D003872:Dermatitis / Q000150:complications; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000209:etiology; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine; D000666:Amphotericin B