Controlled release of dehydroacetic acid sodium salt for the stability improvement of cosmetic formulations*.
Synopsis The kinetics of decomposition of the sodium salt of dehydroacetic acid (DHA.Na) in presence of formaldehyde and formaldehyde donors was investigated. The possibility of preparing systems capable of providing the cosmetic preparation with increasing amounts of DHA.Na corresponding to portions interacted with formaldehyde was explored. Data relevant to matrices prepared from ethylcellulose and polyethylene by casting and moulding process, respectively, are reported and discussed. Experimental data demonstrate the possibility of preparing polymeric systems able to control in terms of rate and duration the relase of DHA.Na, according to time and concentration needs of a typical cosmetic formulation.
Gazzaniga
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A
Istituto Chimico Farmaceutico, Università di Milano, Viale Abruzzi 42, 20131 Milano, Italy.
Sangalli
M E
ME
Giordano
F
F
Conte
U
U
Semenzato
A
A
Bettero
A
A