title: Neuroendocrine carcinoma of the thymus gland with sternal invasion.
abstract: Large-cell neuroendocrine carcinoma of the thymus is a rare cancer that is more aggressive than other thymic epithelial tumors with poorer prognosis. We report one such case in a 44-year-old male patient with invasion into the upper 2/3rd of the sternum but no endocrinopathy. Complete enbloc resection of the tumor with adherent pericardium, upper 2/3rd of the sternum and mediastinal lymphadenectomy was performed. The chest wall was reconstructed with polypropylene mesh and bilateral pectoralis major muscle advancement flap cover. A search of PubMed database with user query words 'neuroendocrine carcinoma, thymus gland, sternal invasion' revealed no case report in the literature of thymic neuroendocrine carcinoma with invasion of the sternum.
authors.affiliation: Department of Surgical Disciplines, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Roman
authors.initials: R
authors.lastname: Dutta
authors.forename: Arvind
authors.initials: A
authors.lastname: Kumar
authors.forename: Tarun
authors.initials: T
authors.lastname: Jindal
authors.forename: Sandeep Rajinder
authors.initials: SR
authors.lastname: Mathur
mesh_terms: D000328:Adult; D001706:Biopsy; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D009361:Neoplasm Invasiveness; D019637:Orthopedic Procedures; D010492:Pericardiectomy; D018714:Radiotherapy, Adjuvant; D013249:Sternum / Q000473:pathology* / Q000601:surgery; D013524:Surgical Flaps; D013526:Surgical Mesh; D013934:Thymectomy; D013953:Thymus Neoplasms / Q000473:pathology* / Q000628:therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome