title: [Clinical study on aggressive rhinocerebral mucormycosis].
abstract: OBJECTIVE
  To study the clinical diagnosis, course and combined therapy of aggressive rhinocerebral mucormycosis.
  
  
  METHODS
  The clinical feature, diagnosis and therapy were analyzed in 5 cases with rhinocerebral mucormycosis throughout disease progress. Good treatments were found by analyzing curative effect of different treatment.
  
  
  RESULTS
  One patient died within three weeks in hospital three patients survived from 2 months to 2 years; and one patient was alive over 3 years. The mortality rate was 80% in this study.
  
  
  CONCLUSIONS
  Rhinocerebral mucormycosis is always secondary to patients with severe diseases and bad immunologic function. The lesion can invade the orbit and brain quickly, and the mortality rate is high. The cause of the disease can be retarded by clearing up the focus early and removing the environment of fungi thriving with combined therapy. It is effective of remodelling the necrotic tissues by nasal endoscopy.
authors.affiliation: Hospital of Otolaryngology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. entxgfess@163.com
authors.forename: Xuan
authors.initials: X
authors.lastname: Wu
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Weiping
authors.initials: W
authors.lastname: Wen
authors.forename: Jiebo
authors.initials: J
authors.lastname: Guo
mesh_terms: D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000175:diagnosis / Q000628:therapy; D009668:Nose Diseases / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy