title: Neuronal protective effects of focal ischemic pre- and/or postconditioning on the model of transient focal cerebral ischemia in rats.
abstract: We investigated the neuroprotective effects of pre- and postconditioning on infarct volume in the transient middle cerebral artery occlusion (MCAo) model in rats. Thirty-two male rats were divided into occlusion, preconditioning, postconditioning and both pre- and postconditioning groups. MCAo (120 minutes) was monitored with continuous cerebral tissue oxygen (O2) pressure (PtiO2). Pre-conditioning comprised 10 minutes of MCAo, 24 hours prior to the 120 minute MCAo. The postconditioning algorithm was 30 seconds of reperfusion followed by 30 seconds of MCAo. This cycle was repeated 3 times at the onset of reperfusion. Comparison of infarct volumes showed a significant difference between the conditioned groups and occlusion group. Although there was better protection in the preconditioning group compared with the other two conditioned groups, the results did not reach statistically significant levels. The results suggest that preconditioning, postconditioning and pre/post conditioning have protective effects on cerebral ischemia.
authors.affiliation: Department of Neurosurgery, Uludag University School of Medicine, Bursa, Turkey.
authors.forename: M Ozgur
authors.initials: MO
authors.lastname: Taskapilioglu
authors.forename: Tulin
authors.initials: T
authors.lastname: Alkan
authors.forename: Bulent
authors.initials: B
authors.lastname: Goren
authors.forename: Kudret
authors.initials: K
authors.lastname: Tureyen
authors.forename: Soner
authors.initials: S
authors.lastname: Sahin
authors.forename: Ozlem
authors.initials: O
authors.lastname: Taskapilioglu
authors.forename: Ender
authors.initials: E
authors.lastname: Korfali
mesh_terms: D000818:Animals; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000517:prevention & control*; D019194:Ischemic Preconditioning / Q000379:methods*; D008297:Male; D009460:Neurologic Examination; D010100:Oxygen / Q000378:metabolism; D011312:Pressure; D051381:Rats; D017207:Rats, Sprague-Dawley; D015424:Reperfusion / Q000379:methods*; D015427:Reperfusion Injury; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D010100:Oxygen