title: Mitral valve-sparing procedures and prosthetic heart valve failure: a case report.
abstract: Prosthetic heart valve dysfunction due to thrombus or pannus formation can be a life-threatening complication. The present report describes a 47-year-old woman who developed valvular cardiomyopathy after chorda-sparing mitral valve replacement, and subsequently underwent heart transplantation for progressive heart failure. The explanted mitral valve prosthesis showed significant thrombus and pannus leading to reduced leaflet mobility and valvular stenosis. The present report illustrates the role of the subvalvular apparatus and pannus in prosthesis dysfunction.
authors.affiliation: Department of Pathology, Toronto General Hospital, University Health Network, Ontario, Canada.
authors.forename: N A
authors.initials: NA
authors.lastname: Khan
authors.forename: J
authors.initials: J
authors.lastname: Butany
authors.forename: S W
authors.initials: SW
authors.lastname: Leong
authors.forename: V
authors.initials: V
authors.lastname: Rao
authors.forename: R J
authors.initials: RJ
authors.lastname: Cusimano
authors.forename: H J
authors.initials: HJ
authors.lastname: Ross
mesh_terms: D019917:Blood Vessel Prosthesis Implantation / Q000379:methods; D002311:Cardiomyopathy, Dilated / Q000150:complications / Q000473:pathology / Q000601:surgery*; D002815:Chordae Tendineae / Q000601:surgery; D018450:Disease Progression; D005260:Female; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology; D006333:Heart Failure / Q000209:etiology / Q000601:surgery; D016027:Heart Transplantation; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D009206:Myocardium / Q000473:pathology; D017211:Treatment Failure