Efficient iron/copper cocatalyzed S-arylations of thiols with aryl halides.
A practical and promising protocol was developed for S-arylations of various thiols with different substituted aryl halides. The reactions were readily facilitated to afford desired thioethers under mild conditions in good to excellent yields. The versatility, air-stability, operational simplicity of this method, in addition to the higher yields and shorter reaction time it provides, highlight the potential of using this method in large scale library synthesis involving carbon-heteroatom formation.
Ku
Xin
X
Drug Discovery and Design Centre, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
Huang
He
H
Jiang
Hualiang
H
Liu
Hong
H
D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D003300:Copper / Q000737:chemistry*; D005029:Ethylenediamines / Q000138:chemical synthesis / Q000737:chemistry; D006219:Halogens / Q000138:chemical synthesis / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry; D007501:Iron / Q000737:chemistry*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry
D005029:Ethylenediamines; D006219:Halogens; D006841:Hydrocarbons, Aromatic; D013438:Sulfhydryl Compounds; D013440:Sulfides; C005798:N,N,N',N'-tetramethylethylenediamine; D002244:Carbon; D003300:Copper; D007501:Iron