[Post-varicella purpura fulminans: potentially fatal].
Although varicella is usually a benign disease, some of its complications, such as post-varicella purpura fulminans, can be fatal. Its pathophysiological mechanism is caused by the production of antibodies to protein C and protein S in the coagulation cascade. This could have fatal consequences for those patients with partial deficiency of these proteins that develop disseminated intravascular coagulation. Treatment is symptomatic: fresh frozen plasma to treat protein depletion, antithrombin III and heparinization against thrombus formation, and anti-inflammatory drugs (steroids). However, new therapies, such as prostaglandin E1 IV and prostacyclin, are being introduced.
Hernández Blanco
A
A
Servicio de Pediatría, Hospital Universitario San Juan, Alicante, España. aida12@gmail.com
González Montero
R
R
Urán Moreno
M M
MM
Caturla Martínez-Moratalla
J
J
Moya Benavent
M
M
D000671:Amputation, Surgical; D002644:Chickenpox / Q000150:complications*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007866:Leg / Q000601:surgery; D055665:Purpura Fulminans / Q000601:surgery / Q000821:virology*