Advances in beta-cell imaging.
Diabetes mellitus results in impaired insulin production by pancreatic beta-cells due to their death and/or dysfunction. There is a growing unmet need among diabetes researches and clinicians to assess the level of surviving beta-cells non-invasively. This review will focus on employment of state-of-the-art in vivo imaging methods to estimate and evaluate beta-cell mass in animal models of diabetes.
Moore
Anna
A
Molecular Imaging Laboratory, MGH/MIT/HMS Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital/Harvard Medical School, Charlestown, MA 02129, USA. amoore@helix.mgh.harvard.edu
D000818:Animals; D003920:Diabetes Mellitus / Q000175:diagnosis*; D003952:Diagnostic Imaging / Q000639:trends*; D006801:Humans; D050417:Insulin-Secreting Cells / Q000000981:diagnostic imaging* / Q000473:pathology*; D015336:Molecular Probe Techniques / Q000639:trends*; D011877:Radionuclide Imaging