[Effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats].
OBJECTIVE
To determine the effect of clofibrate on myocardial triglyceride accumulation in female obese Zucker rats and its role in lipotoxic heart disease.


METHODS
Twenty four female Zucker rats were divided into four groups: lean rats+vehicle, lean rats+clofibrate, obese rats + vehicle, obese rats+clofibrate. Daily intraperitoneal injection of clofibrate (300 mg/kg) or vehicle (olive oil, 1 mL/kg) was given to the rats for two weeks. Plasma glucose, insulin, free fatty acids, triglycerdies, cholesterol, and cardiac triglycerdies and fatty acids were measured.


RESULTS
Clofibrate normalized plasma free fatty acid and cholesterol and reduced plasma triglyceride and insulin in obese rats. However, clofibrate led to accumulation of heart TG and increased myocardial long-chain unsaturated and monounsaturated fatty acids in obese rats.


CONCLUSIONS
Clofibrate aggravates myocardial triglyceride accumulation in female obese Zucker rats. Further studies are needed for the use of clofibrate in treating cardiac lipid accumulation.
Yang
Bang-xiang
BX
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Li
Yu
Y
Liao
Ren
R
Tian
Qi
Q
D000818:Animals; D009202:Cardiomyopathies / Q000188:drug therapy / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000494:pharmacology*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D009206:Myocardium / Q000378:metabolism*; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D014280:Triglycerides / Q000097:blood / Q000378:metabolism*
D005227:Fatty Acids; D000960:Hypolipidemic Agents; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D002994:Clofibrate