title: Preliminary genome-wide association study of bipolar disorder in the Japanese population.
abstract: Recent progress in genotyping technology and the development of public databases has enabled large-scale genome-wide association tests with diseases. We performed a two-stage genome-wide association study (GWAS) of bipolar disorder (BD) in Japanese cohorts. First we used Affymetrix 100K GeneChip arrays in the analysis of 107 cases with bipolar I disorder and 107 controls, and selected markers that were nominally significant (P < 0.01) in at least one of the three models (1,577 markers in total). In the follow-up stage, we analyzed these markers using an Illumina platform (1,526 markers; 51 markers were not designable for the platform) and an independent sample set, which consisted of 395 cases (bipolar I + II) and 409 controls. We also assessed the population stratification of current samples using principal components analysis. After the two-stage analysis, 89 markers remained nominally significant (allelic P < 0.05) with the same allele being consistently over-represented in both the first and the follow-up stages. However, none of these were significant after correction for multiple-testing by false discovery rates. Sample stratification was virtually negligible. Collectively, this is the first GWAS of BD in the Japanese population. But given the small sample size and the limited genomic coverage, these results should be taken as preliminary.
authors.affiliation: RIKEN Brain Science Institute, Saitama, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Hattori
authors.forename: Tomoko
authors.initials: T
authors.lastname: Toyota
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ishitsuka
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Iwayama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ujike
authors.forename: Yukitaka
authors.initials: Y
authors.lastname: Morita
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kodama
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakata
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Minabe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Iwata
authors.forename: Nori
authors.initials: N
authors.lastname: Takei
authors.forename: Norio
authors.initials: N
authors.lastname: Mori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Naitoh
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamanouchi
authors.forename: Nakao
authors.initials: N
authors.lastname: Iwata
authors.forename: Norio
authors.initials: N
authors.lastname: Ozaki
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Toru
authors.initials: T
authors.lastname: Nishikawa
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kashiwa
authors.forename: Mika
authors.initials: M
authors.lastname: Suzuki
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Shioe
authors.forename: Manabu
authors.initials: M
authors.lastname: Shinohara
authors.forename: Masami
authors.initials: M
authors.lastname: Hirano
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Nanko
authors.forename: Akihisa
authors.initials: A
authors.lastname: Akahane
authors.forename: Mikako
authors.initials: M
authors.lastname: Ueno
authors.forename: Naoshi
authors.initials: N
authors.lastname: Kaneko
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Someya
authors.forename: Kenji
authors.initials: K
authors.lastname: Hashimoto
authors.forename: Masaomi
authors.initials: M
authors.lastname: Iyo
authors.forename: Masanari
authors.initials: M
authors.lastname: Itokawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Arai
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nankai
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inada
authors.forename: Sumiko
authors.initials: S
authors.lastname: Yoshida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kunugi
authors.forename: Michiko
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Iijima
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Teruhiko
authors.initials: T
authors.lastname: Higuchi
authors.forename: Takeo
authors.initials: T
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D001714:Bipolar Disorder / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005819:Genetic Markers; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D010865:Pilot Projects; D025341:Principal Component Analysis
chemical_list: D005819:Genetic Markers