title: Structure-activity relationship studies of curcumin analogues.
abstract: Two series of curcumin analogues, a total of twenty-four compounds, were synthesized and evaluated. The most potent compound, compound 23, showed potent growth inhibitory activities on both prostate and breast cancer lines with IC(50) values in sub-micromolar range, fifty times more potent than curcumin. Curcumin analogues might be potential anti-tumor agents for breast and prostate cancers.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, 338 Parks Hall, 500 West 12th Avenue, Columbus, OH 43210, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Fuchs
authors.forename: Bulbul
authors.initials: B
authors.lastname: Pandit
authors.forename: Deepak
authors.initials: D
authors.lastname: Bhasin
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Etter
authors.forename: Nicholas
authors.initials: N
authors.lastname: Regan
authors.forename: Dalia
authors.initials: D
authors.lastname: Abdelhamid
authors.forename: Chenglong
authors.initials: C
authors.lastname: Li
authors.forename: Jiayuh
authors.initials: J
authors.lastname: Lin
authors.forename: Pui-Kai
authors.initials: PK
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D003474:Curcumin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008297:Male; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010696:Phloroglucinol; D003474:Curcumin