Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression.
Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.
Kelly
Claire M
CM
Cardiff University, UK. kellycm@cf.ac.uk
Precious
Sophie V
SV
Scherf
Caroline
C
Penketh
Richard
R
Amso
Nazar N
NN
Battersby
Alysia
A
Allen
Nicholas D
ND
Dunnett
Stephen B
SB
Rosser
Anne E
AE
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology* / Q000601:surgery*; D002470:Cell Survival; D002478:Cells, Cultured; D003888:Desensitization, Immunologic / Q000379:methods*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D009474:Neurons / Q000276:immunology* / Q000637:transplantation*; D051381:Rats; D033581:Stem Cell Transplantation / Q000379:methods*