title: Cerebral edema before onset of therapy in newly diagnosed type 2 diabetes.
abstract: To discuss the management of a rare case of cerebral edema before initiation of therapy in an adolescent with new-onset type 2 diabetes. The University of Arkansas for Medical Sciences Institutional Review Board approved the review of medical records. A previously healthy obese adolescent female suffered diabetic ketoacidosis (DKA)-related cerebral edema before initiation of therapy. Prompt management was associated with complete recovery. DKA-related cerebral edema before treatment can occur in patients with new-onset type 2 diabetes. Use of mannitol and hypertonic saline solution should be considered in the management of DKA-related cerebral edema.
authors.affiliation: Division of Pediatric Endocrinology, Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Sciences, Little Rock, AR 72202, USA. moralesalba@uams.edu
authors.forename: Alba E
authors.initials: AE
authors.lastname: Morales
authors.forename: Kerri A
authors.initials: KA
authors.lastname: Daniels
mesh_terms: D000293:Adolescent; D001929:Brain Edema / Q000188:drug therapy / Q000209:etiology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D016883:Diabetic Ketoacidosis / Q000150:complications*; D004234:Diuretics, Osmotic / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008353:Mannitol / Q000627:therapeutic use; D012462:Saline Solution, Hypertonic
chemical_list: D004234:Diuretics, Osmotic; D012462:Saline Solution, Hypertonic; D008353:Mannitol