Pulsatile flow in a coronary artery using multiphase kinetic theory.
Pulsatile flow in a model of a right coronary artery (RCA) was previously modeled as a single-phase fluid and as a two-phase fluid using experimental rheological data for blood as a function of hematocrit and shear rate. Here we present a multiphase kinetic theory model which has been shown to compute correctly the viscosity of red blood cells (RBCs) and their migration away from vessel walls: the Fahraeus-Lindqvist effect. The computed RBC viscosity decreases with shear rate and vessel size, consistent with measurements. The pulsatile computations were performed using a typical cardiac waveform until a limit cycle was well established. The RBC volume fractions, shear stresses, shear stress gradients, granular temperatures, viscosities, and phase velocities varied with time and position during each cardiac cycle. Steady-state computations were also performed and were found to compare well with time-averaged transient results. The wall shear stress and wall shear stress gradients (both spatial and temporal) were found to be highest on the inside area of maximum curvature. Potential atherosclerosis sites are identified using these computational results.
Huang
Jing
J
Illinois Institute of Technology, Department of Chemical and Biological Engineering, Chicago, IL 60616, USA.
Lyczkowski
Robert W
RW
Gidaspow
Dimitri
D
D001809:Blood Viscosity / Q000502:physiology; D003198:Computer Simulation; D003331:Coronary Vessels / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology; D021621:Imaging, Three-Dimensional; D007700:Kinetics; D008954:Models, Biological; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012212:Rheology