title: HSV-2 ICP34.5 protein modulates herpes simplex virus glycoprotein processing.
abstract: The ICP34.5 gene from HSV-2 strain 333 was cloned and, when expressed in Vero cells, enhanced the efficiency and extent of glycoprotein processing of glycoprotein C (gC1), a representative viral glycoprotein, during infection with HSV-1 SP7. The ICP34.5 from HSV-1 SP7 limits the extent and efficiency of viral glycoprotein processing. The ability of the HSV-2 ICP34.5 protein to enhance the efficiency and extent of HSV-1 SP7 glycoprotein processing indicates that modulation of viral glycoprotein processing is also a property of the HSV-2 ICP34.5 protein.
authors.affiliation: Integrative Medical Sciences, Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, 44272, USA.
authors.forename: Somik
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Jason W
authors.initials: JW
authors.lastname: Wang
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Cismowski
authors.forename: John R
authors.initials: JR
authors.lastname: Bower
authors.forename: Kenneth Steven
authors.initials: KS
authors.lastname: Rosenthal
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D015870:Gene Expression; D018259:Herpesvirus 1, Human / Q000235:genetics*; D018258:Herpesvirus 2, Human / Q000235:genetics*; D011499:Protein Processing, Post-Translational; D014709:Vero Cells; D014759:Viral Envelope Proteins / Q000378:metabolism*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C540071:ICP34.5 protein, human herpesvirus-2; D014759:Viral Envelope Proteins; D014764:Viral Proteins; C066469:gamma 34.5 protein, Human herpesvirus 1; C038535:glycoprotein gC, herpes simplex virus type 1