Association of cytokine and chemokine gene polymorphisms with severe acute respiratory syndrome.
1. The IFN-gamma +874A allele and RANTES -28 G allele are risk factors for SARS susceptibility. 2. The RANTES -28 G allele plays a role in the pathogenesis of SARS. 3. The polymorphisms of IL-10, TNF-alpha, IL-12, IP-10, Mig and MCP-1 are not associated with SARS susceptibility.
Lau
Y L
YL
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Pokfulam, Hong Kong SAR, China. lauylung@hkucc.hku.hk
Peiris
J S M
JS
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000235:genetics*; D018925:Chemokines / Q000235:genetics; D016207:Cytokines / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006723:Hong Kong; D006801:Humans; D007371:Interferon-gamma / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors; D045169:Severe Acute Respiratory Syndrome / Q000235:genetics*; D055815:Young Adult
D018946:Chemokine CCL5; D018925:Chemokines; D016207:Cytokines; D007371:Interferon-gamma