Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles.
Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.
Bouchard
Louis-S
LS
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA. bouchard@chem.ucla.edu
Anwar
M Sabieh
MS
Liu
Gang L
GL
Hann
Byron
B
Xie
Z Harry
ZH
Gray
Joe W
JW
Wang
Xueding
X
Pines
Alexander
A
Chen
Fanqing Frank
FF
D003035:Cobalt; D003952:Diagnostic Imaging / Q000379:methods; D006046:Gold; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles; D012680:Sensitivity and Specificity; D014054:Tomography / Q000379:methods*
D003035:Cobalt; D006046:Gold