title: Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation.
abstract: To evaluate the differences in graft survival and histopathological characteristics between full-thickness and lamellar orthotopic corneal xenotransplantation in a pig-to-rabbit model, we orthotopically transplanted a full-thickness or the anterior half of a pig's cornea onto the OD of 16 rabbits. As a result, the median survival were 16.83 and 29.07 days for the full-thickness and lamellar xenografts, respectively (P = 0.0005). Histologically, the full-thickness corneal xenografts had massive infiltration by eosinophils, whereas the lamellar xenografts showed predominantly mononuclear infiltrates (P < 0.05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full-thickness xenografts and each type of graft demonstrated different rejection mechanisms.
authors.affiliation: Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
authors.forename: Joo Youn
authors.initials: JY
authors.lastname: Oh
authors.forename: Mee Kum
authors.initials: MK
authors.lastname: Kim
authors.forename: Jung Hwa
authors.initials: JH
authors.lastname: Ko
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Lee
authors.forename: Chung-Gyu
authors.initials: CG
authors.lastname: Park
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Kim
authors.forename: Won Ryang
authors.initials: WR
authors.lastname: Wee
authors.forename: Jin Hak
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000818:Animals; D003315:Cornea / Q000166:cytology / Q000473:pathology; D016039:Corneal Transplantation / Q000379:methods / Q000662:veterinary*; D004804:Eosinophils; D006084:Graft Rejection; D007963:Leukocytes, Mononuclear; D011817:Rabbits; D013552:Swine; D014183:Transplantation, Heterologous / Q000662:veterinary*