Alarmins and antimicrobial immunity.
Alarmins are endogenous mediators capable of enhancing innate and adaptive immune response through induction of concomitant recruitment and activation of antigen-presenting cells. Here we provide a brief overview of various alarmins, highlight their critical roles in innate and adaptive antimicrobial immunity, and speculate on potential usage of alarmins in combating aspergillosis.
Yang
D
D
Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research, National Cancer Institute at Frederick, National Institute of Health, 1050 Boyles Street, Frederick, MD 21702-1201, USA. dyang@ncifcrf.gov
Oppenheim
J J
JJ
D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy; D003141:Communicable Diseases / Q000276:immunology*; D006801:Humans; D007155:Immunologic Factors / Q000276:immunology*
D007155:Immunologic Factors