Preserved residual renal function is associated with lower oxidative stress in peritoneal dialysis patients.
BACKGROUND
Residual renal function (RRF) correlates with survival in peritoneal dialysis (PD). We investigated the association between oxidative stress and RRF in PD.


METHODS
Adequacy of dialysis, total and free malondialdehydes (MDA), and lipid hydroperoxides (LHP) were obtained from 23 stable PD patients.


RESULTS
Free MDA level decreased with total weekly Kt/V urea (r = -0.51, P = 0.013) and urinary Kt/V (KRU) (r = -0.53, P = 0.009), but not with peritoneal Kt/V. Similar results were found with LHP level. In multivariate analysis, total weekly Kt/V urea and KRU remained associated with free MDA and LHP, independently of gender, nutritional or inflammatory status, and peritoneal permeability.


CONCLUSIONS
A preserved RRF is associated with lower serum levels of lipid peroxidation products among PD patients.
Ignace
Sophie
S
Hospices Civils de Lyon, Department of Nephrology and Hypertension, Edouard Herriot Hospital, 5, Place d'Arsonval, 69 347 Lyon Cedex 03, France. sophie.ignace@free.fr
Fouque
Denis
D
Arkouche
Walid
W
Steghens
Jean-Paul
JP
Guebre-Egziabher
Fitsum
F
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology* / Q000628:therapy*; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015999:Multivariate Analysis; D018384:Oxidative Stress / Q000502:physiology*; D010530:Peritoneal Dialysis
D008054:Lipid Peroxides; D008315:Malondialdehyde