title: Fish consumption, allergic sensitisation and allergic diseases in adults.
abstract: BACKGROUND
  Previous studies have suggested that fish intake plays a protective role in the development of allergic diseases because of its high content of n-3 very long chain polyunsaturated fatty acid (VLC-PUFA). However, it is not clear whether fish intake also has a beneficial effect in adulthood, when allergic diseases are thought to be predominantly manifested.
  
  
  METHODS
  Data from 388 adults from German study centres within the European Community Respiratory Health Study II were analysed. These subjects completed an extensive interviewer-administered questionnaire as well as a food frequency questionnaire, lung function measurement and blood drawing for specific IgE testing at the study centre.
  
  
  RESULTS
  Allergic sensitisation (RAST >or=2) was negatively associated with high fish consumption (adjusted OR 0.20, 95% CI 0.05-0.83) and high docosahexaenoic acid (DHA) intake (adjusted OR 0.26, 95% CI 0.07-0.95) in females but not in males when comparing the fourth quartile with the first quartile of intake. No other outcome was related to fish or DHA consumption.
  
  
  CONCLUSIONS
  The findings of this study suggest that adult females with a high fish and DHA intake have a lower rate of allergic sensitisation. It is not understood why this association was only seen in females, but gender-related differences in metabolism of PUFAs could be a possible explanation.
authors.affiliation: Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Schnappinger
authors.forename: Stefanie
authors.initials: S
authors.lastname: Sausenthaler
authors.forename: Jakob
authors.initials: J
authors.lastname: Linseisen
authors.forename: Hans
authors.initials: H
authors.lastname: Hauner
authors.forename: Joachim
authors.initials: J
authors.lastname: Heinrich
mesh_terms: D000328:Adult; D004032:Diet; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000378:metabolism / Q000502:physiology; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control; D007073:Immunoglobulin E / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012129:Respiratory Function Tests; D017747:Seafood; D012737:Sex Factors; D011795:Surveys and Questionnaires
chemical_list: D015525:Fatty Acids, Omega-3; D007073:Immunoglobulin E