title: C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
abstract: Inflammation is believed to play a role in prostate cancer (PCa) etiology, but it is unclear whether inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) associate with PCa risk in older men. Using Cox regression, we assessed the relationship between baseline concentrations of CRP and IL-6 and the subsequent PCa risk in the Cardiovascular Health Study, a population-based cohort study of mostly European American men of ages >64 years (n = 2,234; mean follow-up = 8.7 years; 215 incident PCa cases). We also tested associations between CRP and IL-6 tagSNPs and PCa risk, focusing on SNPs that are known to associate with circulating CRP and/or IL-6. Neither CRP nor IL-6 blood concentrations was associated with PCa risk. The C allele of IL-6 SNP rs1800795 (-174), a known functional variant, was associated with increased risk in a dominant model (HR = 1.44; 95% CI = 1.03-2.01; p = 0.03), but was not statistically significant after accounting for multiple tests (permutation p = 0.21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
authors.affiliation: Institute for Public Health Genetics, University of Washington, Seattle, WA, USA. bpierce@health.bsd.uchicago.edu
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Pierce
authors.forename: Mary L
authors.initials: ML
authors.lastname: Biggs
authors.forename: Marvalyn
authors.initials: M
authors.lastname: DeCambre
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Reiner
authors.forename: Christopher
authors.initials: C
authors.lastname: Li
authors.forename: Annette
authors.initials: A
authors.lastname: Fitzpatrick
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Carlson
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Austin
mesh_terms: D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000150:complications; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000378:metabolism; D012307:Risk Factors; D044465:White People
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein