title: Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA.
abstract: AsbA catalyses the highly enantioselective desymmetrisation of citric acid via ATP-dependent condensation with spermidine, as well as the condensation of citric acid with several spermidine analogues and the condensation of the citric acid analogue tricarballylic acid with spermidine, suggesting that it may be a useful biocatalyst for asymmetric synthesis.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
authors.forename: Daniel
authors.initials: D
authors.lastname: Oves-Costales
authors.forename: Lijiang
authors.initials: L
authors.lastname: Song
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Challis
mesh_terms: D001408:Bacillus anthracis / Q000201:enzymology*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D019343:Citric Acid / Q000737:chemistry*; D015394:Molecular Structure; D013095:Spermidine / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001549:Benzamides; C450699:petrobactin; D019343:Citric Acid; D013095:Spermidine