Studies on distribution of para-methoxymethamphetamine (PMMA) designer drug in rats using gas chromatography-mass spectrometry.
para-Methoxymethamphetamine (PMMA) is an abused psychedelic compound with reports of several intoxications and deaths after ingestion. However, its pharmacokinetics based on a controlled study is unknown and only partial information on its biotransformation is available. Our experimental study was designed for the time disposition profile of PMMA and its metabolites para-methoxyamphetamine (PMA), para-hydroxymethamphetamine (OH-MAM) and para-hydroxyamphetamine (OH-AM) in blood and biological tissues in rats after the bolus subcutaneous dose 40 mg/kg using a validated GC-MS method. The experimental results ascertained could be useful for subsequent evaluation of PMMA psychotropic or neurotoxic effects and the diagnostic concern of intoxication.
Rohanova
Miroslava
M
Institute of Forensic Medicine and Toxicology, First Faculty of Medicine, Charles University in Prague, 121 08 Prague 2, Czech Republic. ezerrohan@gmail.com
Balikova
Marie
M
D000818:Animals; D001923:Brain Chemistry; D000697:Central Nervous System Stimulants / Q000032:analysis / Q000493:pharmacokinetics*; D015198:Designer Drugs / Q000493:pharmacokinetics*; D053593:Forensic Toxicology; D008401:Gas Chromatography-Mass Spectrometry; D008099:Liver / Q000737:chemistry; D008168:Lung / Q000737:chemistry; D008297:Male; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
D000697:Central Nervous System Stimulants; D015198:Designer Drugs; C060169:4-methoxymethamphetamine; D008694:Methamphetamine