[Sickle cell anemia in perinatal placental diagnostics].
Hereditary hemoglobinopathies should be considered as differential diagnosis when examining placental specimens for fetal growth retardation and spontaneous abortion. They can cause various macroscopic and microscopic changes in the placenta that are relevant for routine pathology examination. The importance of interdisciplinary co-operation between obstetrics and pathology to achieve optimum diagnostics and therapy planning is demonstrated using the case of a pregnant woman with heterozygous genotype and her child with homozygous genotype. Within this context, the influence of hemoglobinopathies on placental pathology and fetal development are summarized and exemplified.
Oppitz
M
M
Institut für Pathologie und Zytologie, Dr. Horst Schmidt-Klinken, Wiesbaden, Deutschland. moppitz@anatom.uni-tuebingen.de
Klee
A
A
Panitz
H-G
HG
Gonser
M
M
Fisseler-Eckhoff
A
A
D000022:Abortion, Spontaneous / Q000473:pathology; D000328:Adult; D000755:Anemia, Sickle Cell / Q000235:genetics / Q000473:pathology*; D001706:Biopsy; D002823:Chorion / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology; D005838:Genotype; D006453:Hemoglobinopathies / Q000235:genetics / Q000473:pathology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D010920:Placenta / Q000473:pathology; D010922:Placenta Diseases / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology*