title: Thalamic activity that drives visual cortical plasticity.
abstract: Manipulations of activity in one retina can profoundly affect binocular connections in the visual cortex. Retinal activity is relayed to the cortex by the dorsal lateral geniculate nucleus (dLGN). We compared the qualities and amount of activity in the dLGN following monocular eyelid closure and monocular retinal inactivation in awake mice. Our findings substantially alter the interpretation of previous studies and define the afferent activity patterns that trigger cortical plasticity.
authors.affiliation: Howard Hughes Medical Institute, The Picower Institute for Learning and Memory, Cambridge, Massachusetts, USA.
authors.forename: Monica L
authors.initials: ML
authors.lastname: Linden
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Heynen
authors.forename: Robert H
authors.initials: RH
authors.lastname: Haslinger
authors.forename: Mark F
authors.initials: MF
authors.lastname: Bear
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000779:Anesthetics, Local; D000818:Animals; D001931:Brain Mapping; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000502:physiology; D007839:Functional Laterality; D005829:Geniculate Bodies / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D051379:Mice; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010424:Pentobarbital / Q000494:pharmacology; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology; D013997:Time Factors; D015349:Vision, Monocular / Q000187:drug effects / Q000502:physiology; D014793:Visual Cortex / Q000166:cytology* / Q000502:physiology*; D014795:Visual Pathways / Q000187:drug effects / Q000502:physiology; D014796:Visual Perception; D014851:Wakefulness
chemical_list: D000779:Anesthetics, Local; D006993:Hypnotics and Sedatives; D013779:Tetrodotoxin; D010424:Pentobarbital