title: [Unicenter versus multicenter clinical trials].
abstract: Multicenter and single centre clinical trials share methodological problems. Advantages and difficulties have to be learn in order to improve the quality of clinical investigation. In this review, the author analyze some of the domestic experience in the field, and focuss the discution in some issues that may offer particular advantage and difficulties in multicentre clinical trials.
authors.affiliation: Gastroenterólogo, Hospital General de Irapuato, SSA.
authors.forename: J R
authors.initials: JR
authors.lastname: Nogueira de Rojas
mesh_terms: D002986:Clinical Trials as Topic / Q000379:methods*; D003299:Cooperative Behavior; D005762:Gastroenterology / Q000458:organization & administration; D006801:Humans; D008800:Mexico; D015337:Multicenter Studies as Topic; D018579:Patient Selection; D012107:Research Design