Anxiolytic-like effects of ginsenosides Rg3 and Rh2 from red ginseng in the elevated plus-maze model.
The anxiolytic-like effects of red ginseng (RG, the steamed root of Panax ginseng, family Araliaceae), its saponin fraction, and its representative constituents, ginsenosides Rg3 and Rh2, were investigated in mice using the elevated plus-maze test. These agents significantly increased the time spent on the open arms and the number of open-arm entries. The anxiolytic-like activities of Rg3 and Rh2 were antagonized by flumazenil but not by WAY-100635. RG and its constituents, Rg3 and Rh2, may exert anxiolytic effects by antagonizing GABA/benzodiazepines.
Kim
Tae Woo
TW
Gu-Jeong High School, Gangnam-ku, Seoul, Korea.
Choi
Hyuck-Jai
HJ
Kim
Nam-Jae
NJ
Kim
Dong-Hyun
DH
D000818:Animals; D014151:Anti-Anxiety Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects; D002065:Buspirone / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005442:Flumazenil / Q000494:pharmacology; D036145:Ginsenosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D010879:Piperazines / Q000494:pharmacology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D011725:Pyridines / Q000494:pharmacology; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use
D014151:Anti-Anxiety Agents; D036145:Ginsenosides; D010879:Piperazines; D010936:Plant Extracts; D011725:Pyridines; D012503:Saponins; C097367:ginsenoside Rg3; D005442:Flumazenil; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide; C055305:ginsenoside Rh2; D002065:Buspirone