title: Feasibility of microelectrode array (MEA) based on silicone-polyimide hybrid for retina prosthesis.
abstract: OBJECTIVE
  To adopt micropatterning technology in manufacturing silicone elastomer-based microelectrode arrays for retinal stimulation, a silicone-polyimide hybrid microelectrode array was proposed and tested in vivo.
  
  
  METHODS
  Gold microelectrodes were created by semiconductor manufacturing technology based on polyimide and were hybridized with silicone elastomer by spin coating. The stability of the hybrid between the two materials was flex and blister tested. The feasibility of the hybrid electrode was evaluated in the rabbit eye by reviewing optical coherence tomography (OCT) findings after suprachoroidal implantation.
  
  
  RESULTS
  The flex test showed no dehiscence between the two materials for 24 hours of alternative flexion and extension from -45.0 degrees to +45.0 degrees . During the blister test, delamination was observed at 8.33 +/- 1.36 psi of pressure stress; however, this property was improved to 11.50 +/- 1.04 psi by oxygen plasma treatment before hybridization. OCT examination revealed that the implanted electrodes were safely located in the suprachoroidal space during the 4-week follow-up period.
  
  
  CONCLUSIONS
  The silicone-polyimide hybrid microelectrode array showed moderate physical properties, which are suitable for in vivo application. Appropriate pretreatment before hybridization improved electrode stability. In vivo testing indicated that this electrode is suitable as a stimulation electrode in artificial retina.
authors.affiliation: School of Electrical Engineering and Computer Science, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Eui Tae
authors.initials: ET
authors.lastname: Kim
authors.forename: Cinoo
authors.initials: C
authors.lastname: Kim
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Jong-Mo
authors.initials: JM
authors.lastname: Seo
authors.forename: Hum
authors.initials: H
authors.lastname: Chung
authors.forename: Sung June
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D000818:Animals; D001187:Artificial Organs; D001672:Biocompatible Materials; D004567:Electrodes, Implanted; D005240:Feasibility Studies; D006046:Gold; D008839:Microelectrodes; D009757:Nylons; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D011817:Rabbits; D012160:Retina / Q000601:surgery*; D012826:Silicone Elastomers; D041623:Tomography, Optical Coherence
chemical_list: D001672:Biocompatible Materials; D009757:Nylons; D012826:Silicone Elastomers; D006046:Gold