title: [Colchicine: rationale for its use in liver disease].
abstract: Colchicine is a substance derived from the Colchicum Autumnale plant, its pharmacological uses have been demonstrated over the years. Initially used for the treatment of acute gout, it has been utilized for a wide variety of diseases, including mediterranean familial fever, alcoholic, posthepatitic and primary biliary liver cirrhosis. We have demonstrated in different studies that colchicine reduces markedly mortality rates in cirrhotics and the levels of interleukin-1 in patients with primary biliary cirrhosis.
authors.affiliation: Departamento de Gastroenterología, Instituto Nacional de la Nutrición "Salvador Zubirán", Tlalphan, 14000 México, DF.
authors.forename: D
authors.initials: D
authors.lastname: Kershenobich
authors.forename: J
authors.initials: J
authors.lastname: Borovoy
authors.forename: R L
authors.initials: RL
authors.lastname: Guevara
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D003078:Colchicine / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005934:Glucagon / Q000187:drug effects; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D008103:Liver Cirrhosis / Q000188:drug therapy*; D008105:Liver Cirrhosis, Biliary / Q000097:blood / Q000188:drug therapy; D015394:Molecular Structure; D008517:Phytotherapy; D050257:Tubulin Modulators / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007375:Interleukin-1; D050257:Tubulin Modulators; D005934:Glucagon; D003078:Colchicine