title: Prevalence of the metabolic syndrome in kidney transplantation.
abstract: OBJECTIVE
  We investigated the prevalence of the metabolic syndrome (MS) in kidney transplantation patients and assessed its development based on plasma adiponectin levels and the results of an oral glucose tolerance test (OGTT).
  
  
  METHODS
  We performed a cross-sectional study of 94 recipients with stable graft function who underwent kidney transplantation between January 1999 and October 2008. The presence of MS was determined using National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) criteria with body mass index (BMI) used in place of waist circumference. In addition, we measured plasma adiponectin level and performed a 75-g oral GTT.
  
  
  RESULTS
  Fourteen (14.9 %) recipients suffered from MS for a mean period of 46.7 months (range, 1-106) after transplantation. BMI at the time of transplantation was significantly greater in the MS group (23.4 +/- 3.24 vs 20.1 +/- 2.50; P < .0001), whereas plasma adiponectin level was significantly lower (11.95 +/- 5.13 vs 17.71 +/- 8.47; P = .0158). The insulinogenic index values were similar, whereas the homeostatic model assessment of insulin resistance was greater in the MS group (2.598 +/- 1.918 vs 1.340 +/- 0.934; P = .0002).
  
  
  CONCLUSIONS
  The level of adiponectin, which was lower in kidney transplant recipients who developed MS, was negatively correlated with insulin sensitivity. We concluded that a low adiponectin level may correlate with the prevalence of MS in kidney transplantation in association with impaired insulin sensitivity.
authors.affiliation: Department of Renal Transplantation Center, Hyogo Prefectural Nishinomiya Hospital, Hyogo, Japan. hidefumi69@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Kishikawa
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Arichi
authors.forename: A
authors.initials: A
authors.lastname: Okuno
authors.forename: N
authors.initials: N
authors.lastname: Fujii
authors.forename: M
authors.initials: M
authors.lastname: Kyo
authors.forename: S
authors.initials: S
authors.lastname: Takahara
authors.forename: Y
authors.initials: Y
authors.lastname: Ichikawa
mesh_terms: D052242:Adiponectin / Q000097:blood; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D013997:Time Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers