The good, the bad and the ugly: a neuropilin-2 story from normal to tumor-associated lymphangiogenesis.
VEGF-C is a crucial player in lymphangiogenesis. Besides VEGFR-2 and VEGFR-3, it also binds NRP2. NRP2 enhances VEGF-C/VEGFR-3 effects in developmental lymphangiogenesis, but its role in adult and tumoral lymphangiogenesis is not known. In their study, Bagri and colleagues demonstrate that blocking NRP2 results in a decrease of metastasis formation, a phenomenon relying on tumoral lymphangiogenesis. Thus, they identified NRP2 as an attractive new target for modulating metastasis.
Roth
Lise
L
INSERM U575 Centre de Neurochimie, Strasbourg, France. Lise.Roth@neurochem.u-strasbg.fr
D000818:Animals; D006262:Health; D006801:Humans; D042583:Lymphangiogenesis; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D039943:Neuropilin-2 / Q000378:metabolism*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D039943:Neuropilin-2; D042461:Vascular Endothelial Growth Factor A