title: Determination of organochlorine pesticide and polychlorinated biphenyl levels in adipose tissue of infertile men.
abstract: During the recent two decades, a remarkable drop in fertility rates has been noticed almost all over the world. A series of studies have showed that environmental factors had the primary role causing the observed adverse trends in the male reproductive health problems. Especially chlorinated hydrocarbons, for instance polychlorinated biphenyls (PCB) and pesticides, could mimic or antagonize the effects of steroid hormones, like estrogens and androgens and possibly interfering with male reproductive capacity. Organochlorine pesticides (OCPs) (i.e. p.p'-DDT, endosulfan...) and PCBs are widespread used chemicals in agriculture and industry for different purposes all over the world. Although direct evidence is lacking, theoretical considerations and epidemiological evidence implicate these compounds as potential hazards to human and wildlife reproductive health. For this purpose, in this study adipose tissue samples have provided from healthy males which were diagnosed as infertile men living in Ankara, Turkey at least for 5 years. Residual levels of OCPs (alpha-BHC, beta-BHC, gamma-BHC, HCB, Endosulfan I, II, p,p'-DDE, and p,p'-DDT) and seven major persistent PCB congeners (PCB 28, 52, 101, 118, 138, 153, and 180) were measured in 25 infertile men and 21 healthy men's adipose tissue samples by GC-ECD. Levels of OCPs and PCBs in adipose tissue of infertile men compared with those provided from controls. When the concentrations of each of the OCP were compared between the fertile and infertile groups, no statistical significance was obtained. Concentrations of each of the PCB congeners were compared between the fertile and infertile groups, no statistical significance was obtained (p > 0.05), except for 2,2',5,5'-Tetrachlorobiphenyl (PCB 52) (p = 0.032) and 2,2',3,4,4',5,5'-heptachlorobiphenyl (PCB 180) (p = 0.017).
authors.affiliation: Faculty of Pharmacy, Department of Toxicology, Gazi University, 06330, Hipodrom, Ankara, Turkey. ismetc@gazi.edu.tr
authors.forename: Ismet
authors.initials: I
authors.lastname: Cok
authors.forename: Tuba Calik
authors.initials: TC
authors.lastname: Durmaz
authors.forename: Emre
authors.initials: E
authors.lastname: Durmaz
authors.forename: M Hakan
authors.initials: MH
authors.lastname: Satiroglu
authors.forename: Cihan
authors.initials: C
authors.lastname: Kabukcu
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D002849:Chromatography, Gas; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D007248:Infertility, Male / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010575:Pesticides / Q000378:metabolism*; D011078:Polychlorinated Biphenyls / Q000378:metabolism*
chemical_list: D006843:Hydrocarbons, Chlorinated; D010575:Pesticides; D011078:Polychlorinated Biphenyls