Physiological and pathophysiological functions of SIRT1.
The human SIRT1 is a nuclear enzyme from the class III histone deacetylases (HDACs) which is widely distributed in mammalian tissues. A variety of SIRT1 substrates hints that this protein is involved in the regulation of diverse biological processes, including cell survival, apoptosis, gluconeogenesis, adipogenesis, lipolysis, stress resistance, muscle differentiation, and insulin secretion. This review emphasizes catalytic properties of SIRT1 and its role in apoptosis, insulin pathway, and neuron survival.
Wojcik
M
M
Department of Structural Biology, Medical University of Łódz, 7/9 Zeligowskiego Str., 90-752 Lodz, Poland.
Mac-Marcjanek
K
K
Wozniak
L A
LA
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002384:Catalysis; D002470:Cell Survival / Q000502:physiology; D056572:Histone Deacetylase Inhibitors; D006655:Histone Deacetylases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology; D037761:Sirtuins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*
D056572:Histone Deacetylase Inhibitors; D007328:Insulin; D037761:Sirtuins; D006655:Histone Deacetylases