Vpr-induced DNA double-strand breaks: molecular mechanism and biological relevance.
We focus on the role of Vpr in inducing DNA double-strand breaks (DSBs) in the host cell. Based on the summarized findings of Vpr-induced DSBs and the finding of Vpr in the plasma of HIV-1-positive patients, we discuss the roles of Vpr in viral infection, especially viral infection of resting macrophages. We also describe the possible involvement of Vpr in non-AIDS-defining cancers, which represent an emerging crisis in HIV-1-positive patients.
Nakai-Murakami
Chikako
C
Department of Intractable Diseases, Research Institute, International Medical Center of Japan, Toyama, Shinuku-ku, Tokyo, Japan.
Minemoto
Yuzuru
Y
Ishizaka
Yukihito
Y
D004247:DNA / Q000378:metabolism*; D053903:DNA Breaks, Double-Stranded; D006801:Humans; D054325:vpr Gene Products, Human Immunodeficiency Virus / Q000378:metabolism*
D054325:vpr Gene Products, Human Immunodeficiency Virus; C514912:vpr protein, Human immunodeficiency virus 1; D004247:DNA