Stereoselective synthesis of multisubstituted enamides via rhodium-catalyzed carbozincation of ynamides.
A new rhodium-catalyzed carbozincation of ynamides has been developed, using diorganozinc reagents or functionalized alkylzinc halides. The reactions are highly regio- and stereoselective, allowing access to a wide range of multisubstituted enamides, which are increasingly important building blocks for organic synthesis. Utilization of the alkenylzinc intermediates in further carbon-carbon bond-forming reactions to form trisubstituted enamides is also possible.
Gourdet
Benoit
B
School of Chemistry, University of Edinburgh, Joseph Black Building, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, United Kingdom.
Lam
Hon Wai
HW
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D009942:Organometallic Compounds / Q000737:chemistry; D012238:Rhodium; D013237:Stereoisomerism; D015032:Zinc
D000577:Amides; D009942:Organometallic Compounds; D012238:Rhodium; D015032:Zinc