title: [Effect of disease modifying anti-rheumatic drugs on radiographic progression in rheumatoid arthritis].
abstract: Because of a paradigm shift in the therapeutic strategy of RA by biologics, the goal of RA therapy became not only the clinical remission, but also the imaging remission. From the results of randomized controlled clinical trials of disease modifying anti-rheumatic drugs (DMARDs), decreased radiographic progression has been documented. In particular, methotrexate (MTX) is described as "anchor drug" of RA therapy because inhibitory effects of MTX on radiographic progression are proved by many clinical trials. Although DMARDs can slow down the radiographic progression with the achievement of clinical remission in RA, some patients still have subclinical synovitis detected by imaging technique. Such subclinical inflammation may explain the observed discrepancy between disease activity and radiographic progression in RA during DMARD therapy.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University.
authors.forename: Naoichiro
authors.initials: N
authors.lastname: Yukawa
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D016572:Cyclosporine / Q000627:therapeutic use; D003545:Cysteine / Q000031:analogs & derivatives / Q000627:therapeutic use; D018450:Disease Progression; D004359:Drug Therapy, Combination; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use; D006801:Humans; D007555:Isoxazoles / Q000627:therapeutic use; D000077339:Leflunomide; D008727:Methotrexate / Q000627:therapeutic use; D010396:Penicillamine / Q000627:therapeutic use; D011859:Radiography; D016032:Randomized Controlled Trials as Topic; D012460:Sulfasalazine / Q000627:therapeutic use; D016559:Tacrolimus / Q000627:therapeutic use
chemical_list: D018501:Antirheumatic Agents; D007555:Isoxazoles; D006052:Gold Sodium Thiomalate; D012460:Sulfasalazine; D016572:Cyclosporine; D000077339:Leflunomide; D010396:Penicillamine; D003545:Cysteine; C026535:bucillamine; D016559:Tacrolimus; D008727:Methotrexate