title: Synthesis and antitubercular screening of imidazole derivatives.
abstract: A series of imidazole based compounds were synthesized by reacting simple imidazoles with alkyl halides or alkyl halocarboxylate in presence of tetrabutylammonium bromide (TBAB). The compounds bearing carbethoxy group undergo amidation with different amines in the presence of DBU to give respective carboxamides. The synthesized compounds were screened against Mycobacterium tuberculosis where compound 17 exhibited very good in vitro antitubercular activity and may serve as a lead for further optimization.
authors.affiliation: Division of Medicinal and Process Chemistry, Central Drug Research Institute, Lucknow, India.
authors.forename: Jyoti
authors.initials: J
authors.lastname: Pandey
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Tiwari
authors.forename: Shyam S
authors.initials: SS
authors.lastname: Verma
authors.forename: Vinita
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: S
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: S
authors.initials: S
authors.lastname: Sinha
authors.forename: A N
authors.initials: AN
authors.lastname: Gaikwad
authors.forename: Rama P
authors.initials: RP
authors.lastname: Tripathi
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D007093:Imidazoles