title: [Conservative anal fistula treatment with collagenic plug and human fibrin sealant. Preliminary results].
abstract: The authors, on the basis of a long clinical experience with human fibrin glue in general surgery, compared two different extracellular matrix (collagen), Surgisis and TissueDura, with human fibrin glue, applied during the operation, and sometimes in postoperative, to obtain the healing of perianal fistulas. The collagenic extracellular matrix provides, according to the rationale suggested, an optimal three-dimensional structure for the fibroblastic implant and neoangiogenesis, hence for the fistula "fibrotizzation" and closure. The encouraging results for transphincteric fistulas and a simple and easy technique push to researchers on samples statistically significant.
authors.affiliation: Seconda Università degli Studi di Napoli, Azienda Ospedaliera Universitaria, DAI di Chirurgia Generale e dei Trapianti.
authors.forename: A
authors.initials: A
authors.lastname: Gubitosi
authors.forename: G
authors.initials: G
authors.lastname: Moccia
authors.forename: F A
authors.initials: FA
authors.lastname: Malinconico
authors.forename: G
authors.initials: G
authors.lastname: Docimo
authors.forename: R
authors.initials: R
authors.lastname: Ruggiero
authors.forename: G
authors.initials: G
authors.lastname: Iside
authors.forename: N
authors.initials: N
authors.lastname: Avenia
authors.forename: L
authors.initials: L
authors.lastname: Docimo
authors.forename: F
authors.initials: F
authors.lastname: Foroni
authors.forename: F
authors.initials: F
authors.lastname: Gilio
authors.forename: L
authors.initials: L
authors.lastname: Sparavigna
authors.forename: M
authors.initials: M
authors.lastname: Agresti
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000818:Animals; D003094:Collagen / Q000008:administration & dosage / Q000627:therapeutic use*; D005109:Extracellular Matrix; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D006736:Horses; D006801:Humans; D008297:Male; D008875:Middle Aged; D012003:Rectal Fistula / Q000628:therapy*; D012008:Recurrence; D012189:Retrospective Studies; D013552:Swine; D014014:Tissue Adhesives / Q000627:therapeutic use*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D003094:Collagen