Enantioselective synthesis of 2-isoxazolines by a one-flask conjugate addition/oxime-transfer process.
Enantioselective isoxazoline synthesis: A combination of 1) a catalytic enantioselective conjugate addition of oximes to alpha,beta-unsaturated aldehydes and 2) an acid-catalyzed intramolecular oxime-transfer reaction lead to the first asymmetric synthesis of 3-unsubstituted 2-isoxazolines (see scheme).
Pohjakallio
Antti
A
Department of Chemistry, Helsinki University of Technology, Kemistintie 1, 02150 Espoo, Finland.
Pihko
Petri M
PM