title: Design and efficient synthesis of novel ascorbyl conjugated peptide with high collagen biosynthesis stimulating effects.
abstract: Collagen is critical for skin strength and elasticity, and its degradation leads to wrinkles that accompany aging. Based emphasis on the aesthetics, we tried to make a new compound that can highly stimulate collagen biosynthesis and synthesized ascorbyl conjugated peptide that is a complex form connected by succinoyl linker. We conducted several in vitro and in vivo experiments to identify if the compound has a potent activity, comparing to the ascorbic acid only for collagen biosynthesis. Our in vitro and in vivo result identified that ascorbyl conjugated peptide can stimulate collagen biosynthesis in human dermis and is assumably stable in the rat skin extracts. In conclusion, we strongly suggest that ascorbyl conjugated peptide can be used as a main ingredient for cosmetic products as well as wound healing agents.
authors.affiliation: 385-19 Doryong-Dong, Yusong-Gu, Peptron, Inc., Daejeon, Republic of Korea.
authors.forename: Ho-Il
authors.initials: HI
authors.lastname: Choi
authors.forename: Heung-Jae
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jong-Il
authors.initials: JI
authors.lastname: Park
authors.forename: Eun-Ho
authors.initials: EH
authors.lastname: Shin
authors.forename: Dong-Won
authors.initials: DW
authors.lastname: Kim
authors.forename: Soung-Soo
authors.initials: SS
authors.lastname: Kim
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D003094:Collagen / Q000096:biosynthesis* / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D015595:Skin Aging
chemical_list: D009842:Oligopeptides; D010455:Peptides; D003094:Collagen; D001205:Ascorbic Acid