Key endothelial signals required for hematopoietic recovery.
In this issue of Cell Stem Cell, Hooper et al. (2009) use a combination of immunohistochemistry and flow cytometry to characterize the bone marrow vasculature both before and after injury. The authors demonstrate that recovery of normal hematopoiesis after myelosuppressive insult is dependent upon endothelial VEGFR2.
Porter
Rebecca L
RL
Wilmot Cancer Center and Endocrine Division, University of Rochester School of Medicine, 601 Elmwood Avenue, Box 693, Rochester, NY 14642, USA.
Calvi
Laura M
LM
D000818:Animals; D001853:Bone Marrow / Q000098:blood supply*; D004730:Endothelium, Vascular / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D051379:Mice; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000502:physiology*
D040301:Vascular Endothelial Growth Factor Receptor-2