title: Peripheral squamous cell carcinoma of lung: patterns of growth with particular focus on airspace filling.
abstract: Because the clinical behavior of low-stage adenocarcinomas of the lung is best predicted when adjusted for the presence of a lepidic growth pattern, we studied the marginal growth patterns of 62 peripheral squamous cell carcinomas of lung focusing on the patterns of marginal/peripheral growth and presence of an alveolar filling component. Approximately one fourth of squamous carcinomas had 20% of their gross diameters composed of carcinoma cells filling airspaces with preserved alveolar architecture, and 26% of these cases had their gross size downgraded from a T2 to a T1 lesion. Despite this size recalculation, insufficient numbers of cases made it impossible to determine if this change had independent prognostic significance for T1/T2N0 lesions. Nonetheless, such a growth pattern was common and should be studied further in larger series to determine if an airspace filling growth pattern in squamous carcinoma is clinically important.
authors.affiliation: Department of Pathology, University of Pittsburgh Medical Center, PA 15213-2582, USA. yousemsa@upmc.edu
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Yousem
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging / Q000379:methods; D011650:Pulmonary Alveoli / Q000473:pathology*