title: Bone cells-biomaterials interactions.
abstract: With the aging population, the incidence of bone defects due to fractures, tumors and infection will increase. Therefore, bone replacement will become an ever bigger and more costly problem. The current standard for bone replacement is autograft, because these transplants are osteoconductive and osteoinductive. However, harvesting an autograft requires additional surgery at the donor site that is related to high level of morbidity. In addition, the quantity of bone tissue that can be harvested is limited. These limitations have necessitated the pursuit of alternatives using biomaterials. The control of bone tissue cell adhesion to biomaterials is an important requirement for the successful incorporation of implants or the colonization of scaffolds for tissue repair. Controlling cells-biomaterials interactions appears of prime importance to influence subsequent biological processes such as cell proliferation and differentiation. Therefore, interactions of cells with biomaterials have been widely studied especially on two-dimensional systems. This review focuses on these interactions.
authors.affiliation: Laboratory of Cells-Biomaterials Biohybrid Systems, Universite de Sherbrooke, Department of Chemical Engineering and Biotechnological Engineering, 2500, Universite Blvd, Sherbrooke, Quebec, Canada, J1K 2R1.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Marquis
authors.forename: Etienne
authors.initials: E
authors.lastname: Lord
authors.forename: Eric
authors.initials: E
authors.lastname: Bergeron
authors.forename: Olivier
authors.initials: O
authors.lastname: Drevelle
authors.forename: Hyunjin
authors.initials: H
authors.lastname: Park
authors.forename: Francois
authors.initials: F
authors.lastname: Cabana
authors.forename: Helena
authors.initials: H
authors.lastname: Senta
authors.forename: Nathalie
authors.initials: N
authors.lastname: Faucheux
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001842:Bone and Bones / Q000166:cytology*; D002448:Cell Adhesion; D006801:Humans
chemical_list: D001672:Biocompatible Materials