title: Ectoenzymes and innate immunity: the role of human CD157 in leukocyte trafficking.
abstract: CD157 is a glycosylphosphatidylinositol-anchored molecule encoded by a member of the CD38/ADP-ribosyl cyclase gene family, involved in the metabolism of NAD. Expressed mainly by cells of the myeloid lineage and by vascular endothelial cells, CD157 has a dual nature behaving both as an ectoenzyme and as a receptor. Although it lacks a cytoplasmic domain, and cannot transduce signals on its own, the molecule compensates for this structural limit by interacting with conventional receptors. Recent experimental evidence suggests that CD157 orchestrates critical functions of human neutrophils. Indeed, CD157-mediated signals promote cell polarization, regulate chemotaxis induced through the high affinity fMLP receptor and control transendothelial migration.
authors.affiliation: Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Torino, Italy. ada.funaro@unito.it
authors.forename: Ada
authors.initials: A
authors.lastname: Funaro
authors.forename: Erika
authors.initials: E
authors.lastname: Ortolan
authors.forename: Paola
authors.initials: P
authors.lastname: Bovino
authors.forename: Nicola
authors.initials: N
authors.lastname: Lo Buono
authors.forename: Giulia
authors.initials: G
authors.lastname: Nacci
authors.forename: Rossella
authors.initials: R
authors.lastname: Parrotta
authors.forename: Enza
authors.initials: E
authors.lastname: Ferrero
authors.forename: Fabio
authors.initials: F
authors.lastname: Malavasi
mesh_terms: D036541:ADP-ribosyl Cyclase / Q000235:genetics / Q000276:immunology*; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology*; D058851:GPI-Linked Proteins; D006801:Humans; D007113:Immunity, Innate; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology; D005810:Multigene Family
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D036541:ADP-ribosyl Cyclase; C087521:ADP-ribosyl cyclase 2