title: Ultrahigh-resolution versus speckle noise-reduction in spectral-domain optical coherence tomography.
abstract: Ultrahigh-resolution (UHR) spectral-domain optical coherence tomography (SD-OCT) and speckle noise-reduced SD-OCT instruments were compared with regard to their ability to visualize retinal microstructures and detect micropathologies in the same series of eyes in this hospital-based study. Both the instruments identically visualized normal retinal structures, except for the retinal ganglion cell layer, which was better delineated by the speckle noise-reduced SD-OCT instrument. Retinal pigment epithelium (RPE) and Bruch's membrane were better delineated by UHR SD-OCT. Retinal and sub-RPE pathologies were also identically visualized by both the instruments. Layer differentiation for locating each pathology was better visualized by speckle noise-reduced SD-OCT.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, 54 Kawaharacho, Shougoin, Sakyo-ku, Kyoto 606-8507, Japan. hangai@kuhp.kyoto-u.ac.jp
authors.forename: Masanori
authors.initials: M
authors.lastname: Hangai
authors.forename: Motoshi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D000368:Aged; D020256:Choroidal Neovascularization / Q000473:pathology; D003930:Diabetic Retinopathy / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000033:anatomy & histology / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis / Q000473:pathology*; D055213:Retinal Pigment Epithelium / Q000473:pathology; D012174:Retinitis Pigmentosa / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000706:statistics & numerical data