Highly enantioselective asymmetric autocatalysis using chiral ruthenium complex-ion-exchanged synthetic hectorite as a chiral initiator.
The synthetic hectorite containing intercalated chiral Delta- and Lambda-tris(1,10-phenanthroline)ruthenium(II) ions acts as a heterogeneous chiral catalyst in the enantioselective addition of diisopropylzinc to pyrimidine-5-carbaldehyde to afford, in combination with asymmetric autocatalytic amplification of enantiomeric excess, 5-pyrimidyl alkanol with high enantiomeric excess.
Kawasaki
Tsuneomi
T
Department of Applied Chemistry, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan.
Omine
Toshiki
T
Suzuki
Kenta
K
Sato
Hisako
H
Yamagishi
Akihiko
A
Soai
Kenso
K
D002384:Catalysis; D007474:Ion Exchange; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010618:Phenanthrolines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D017640:Silicates / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D009942:Organometallic Compounds; D010618:Phenanthrolines; D017640:Silicates; C013547:hectorite; D012428:Ruthenium; C025205:1,10-phenanthroline