Long-term minocycline use for acne in healthy adolescents can cause severe autoimmune hepatitis.
Over the years, a variety of abnormal immune reactions to minocycline have been reported including arthritis, systemic lupus erythematosus, and hepatitis. The current report describes the detailed clinical and pathologic features of 3 patients who presented with chronic/autoimmune hepatitis alone while on minocycline at our hospital over a 2-year period. Minocycline use in these patients was temporally related to onset of severe hepatitis. Adolescents with such a reaction to minocycline have been included in previous reports but have not been well described as a distinct entity. We have compared our cases with similar cases previously reported with a review of the literature and a discussion of the implications for prescribing physicians.
Ramakrishna
Jyoti
J
Pediatric Gastroenterology and Nutrition, Department of Pediatrics, UMass Medical School/UMMHC, Worcester, MA 01655, USA. ramakrij@ummhc.org
Johnson
Amy R
AR
Banner
Barbara F
BF
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056487:Chemical and Drug Induced Liver Injury, Chronic / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D019693:Hepatitis, Autoimmune / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008911:Minocycline / Q000009:adverse effects* / Q000627:therapeutic use; D012720:Severity of Illness Index
D000900:Anti-Bacterial Agents; D008911:Minocycline