title: [Group A streptococcal meningitis in children: clinical characteristics and outcome].
abstract: METHODS
  Group A streptococcal (GAS) invasive infections have been increasingly reported in recent years but meningitis due to GAS remains a rare affection. In children some scarce case reports have been described. The aim of this study was to describe and analyze the clinical and biological data on GAS meningitis recorded in the Bacterial Meningitis (BM) French Surveillance Network (GPIP/ACTIV).
  
  
  RESULTS
  From 2001 through end 2006, 2539 children suffering from proven bacterial meningitis were recorded in the data base. Among them 10 children presented GAS infections. The mean age was 6 years (9 months to 14.1 years) and the sex ratio (male/female) 4/1. Seven out of the 10 patients had a history of community acquired infection before the onset of GAS meningitis : 3 had previous acute otitis media, 1 otitis media with mastoiditis, 2 sinusitis and 1 soft tissue infection. In the 3 remaining children no risk factors of invasive GAS infection could be identified. All but 1 patient survived. The patient who died had no risk factors for invasive infectious disease. He presented with fulminant septicaemia and died 6hours after hospital admission despite appropriate supportive care and prompt antibiotic treatment. The cerebrospinal fluid examination revealed high white blood cells counts (>500/mm(3)) in 8 patients and Gram stained smear showed gram-positive cocci in 6 patients. All the patients received antibiotic regimen including 3(rd) generation cephalosporins before definite bacterial identification and all the strains were susceptible to the first line antibiotic treatment chosen.
  
  
  CONCLUSIONS
  GAS is an uncommon organism causing meningitis in children. In our study upper respiratory tract infection is the most common predisposing factor for GAS meningitis but even apparently healthy children can suffer from this severe form of bacterial meningitis.
authors.affiliation: Service de pédiatrie, Hop de Versailles, Le Chesnay; GPIP : Groupe de Pathologie Infectieuse Pédiatrique. vhentgen@ch-versailles.fr
authors.forename: V
authors.initials: V
authors.lastname: Hentgen
authors.forename: C
authors.initials: C
authors.lastname: Levy
authors.forename: E
authors.initials: E
authors.lastname: Bingen
authors.forename: R
authors.initials: R
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D006801:Humans; D007223:Infant; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000628:therapy; D012744:Sex Ratio; D013290:Streptococcal Infections / Q000175:diagnosis* / Q000628:therapy; D013292:Streptococcus agalactiae / Q000145:classification / Q000302:isolation & purification