title: An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells.
abstract: A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC(50) 5.0 microg/mL.
authors.affiliation: Institut Teknologi Bandung, Natural Products Research Group, Faculty of Mathematics and Natural Sciences, Jalan Ganesha 10, Bandung 40132, Indonesia.
authors.forename: Iqbal
authors.initials: I
authors.lastname: Musthapa
authors.forename: Lia D
authors.initials: LD
authors.lastname: Juliawaty
authors.forename: Yana M
authors.initials: YM
authors.lastname: Syah
authors.forename: Euis H
authors.initials: EH
authors.lastname: Hakim
authors.forename: Jalifah
authors.initials: J
authors.lastname: Latip
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Ghisalberti
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D010082:Oxepins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D005419:Flavonoids; D010082:Oxepins; C540203:artoindonesianin E1