title: An association between resistant hypertension and the null GSTM1 genotype.
abstract: Reduction in expression levels of glutathione S-transferase (GST) mu type 1 (GSTM1) in stroke-prone spontaneously hypertensive rats has recently been reported. GSTM1 genotype was evaluated in 49 patients with resistant hypertension and compared with selected patients with controlled hypertension (n=232) and healthy participants (n=110). Null GSTM1 genotype occurred more frequent in patients with resistant hypertension than those with controlled hypertension (57.1 vs 39.7%; P=0.03; RR 1.96; 95% CI 1.04-3.69) suggesting that null GSTM1 genotype may predispose to resistant hypertension.
authors.forename: I
authors.initials: I
authors.lastname: Cruz-Gonzalez
authors.forename: E
authors.initials: E
authors.lastname: Corral
authors.forename: M
authors.initials: M
authors.lastname: Sanchez-Ledesma
authors.forename: A
authors.initials: A
authors.lastname: Sanchez-Rodriguez
authors.forename: C
authors.initials: C
authors.lastname: Martin-Luengo
authors.forename: R
authors.initials: R
authors.lastname: Gonzalez-Sarmiento
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D005982:Glutathione Transferase