title: Visualization of 3-D high speed ultrahigh resolution optical coherence tomographic data identifies structures visible in 2D frames.
abstract: Optical coherence tomography has allowed unprecedented visualization of ocular structures, but the identity of some visible objects within slices remains unknown. This study reconstructs a number of those objects in 3D space, allowing their identification by observation of their 3D morphology. In the case mottling deep within image slices through the optic disc, C-mode imaging provided visualization of the appearance and distribution of laminar pores. In the case of white spots and streaks sometimes observed in image slices through the cornea, C-mode imaging contoured to the path of those white spots allowed their visual identification as nerves extending radially into the cornea from the limbus. White spots observed in ultra-high resolution retinal image slices were identified as blood within retinal capillaries. C-mode contour-corrected imaging of three dimensional structures provided the identification of previously unidentified structures visible in cross-sectional image slices.
authors.affiliation: UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
authors.forename: Larry
authors.initials: L
authors.lastname: Kagemann
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishikawa
authors.forename: Gadi
authors.initials: G
authors.lastname: Wollstein
authors.forename: Michelle
authors.initials: M
authors.lastname: Gabriele
authors.forename: Joel S
authors.initials: JS
authors.lastname: Schuman
mesh_terms: D003315:Cornea / Q000033:anatomy & histology; D016208:Databases, Factual; D005123:Eye / Q000033:anatomy & histology*; D005451:Fluorescein Angiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D008266:Macula Lutea / Q000033:anatomy & histology; D009898:Optic Disk / Q000033:anatomy & histology; D009900:Optic Nerve / Q000033:anatomy & histology; D012160:Retina / Q000033:anatomy & histology; D012171:Retinal Vessels / Q000033:anatomy & histology; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000706:statistics & numerical data