[Experimental study on antitumor effect of extracts from Cestrum nocturnum in vivo].
OBJECTIVE
To observe the antitumor effects of extracts from Cestrum nocturnum (CN) in vivo.


METHODS
The S180-mice model was used to observe the tumor-inhibition rate of CN and the H22-mice model was used to test the survival time.


RESULTS
The experiment in S180-mice demonstrated that the n-butanol and polysaccharides extracts from CN had obvious effects on tumor inhibition. Its inhibitory rates were 52.30%, 46.75%, 42.28%, 43.19%, 37.96% and 31.82% respectively in the mice administrated the n-butanol and polysaccharides extracts from CN with 30 mg/kg, 20 mg/kg and 15 mg/kg weight dosage. It was noted that tumor formation postponed in mice treated with the n-butanol and polysaccharides extracts from CN compared with the control panel and tumor growth became slower; The n-butanol and polysaccharides extracts from CN could also greatly enhance the life span of mice with H22 ascitic tumors by 116.43%, 44.52%, 20.54%, 109.52%, 112.61% and 115.01%, respectively. The inhibit effects of n-butanol fraction extracts from CN had direct relationship with dose, while the polysaccharides fraction extracts from CN had no obvious relationship with dose.


CONCLUSIONS
The n-butanol and polysaccharides extracts of CN are able to inhibit tumor growth and prolong the lifetime of the tumor-bearing mice in a dose-dependent pattern.
Zhong
Zhen-Guo
ZG
New Drug Development Center of University of Traditional Chinese Medicine, Nanning 530001, China. zhongzg@gxtcmu.edu.cn
Zhao
Shi-Yuan
SY
Lv
Jin-Yan
JY
Li
Peng
P
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D032301:Cestrum / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology*; D015996:Survival Rate
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal