[Glucose metabolism alterations and follow-up study of a non-diabetic adult population].
OBJECTIVE
To determine the appearance of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) at five years of follow-up in a known non-diabetic population.


METHODS



METHODS
nested case control studies (case s-control into a cohort) developed in two stages: 1) identification and characterization of the cohort and 2) follow-up.


METHODS
representative sample of a non-diabetic population between 40 and 75 years old attended in a Primary Health Center.


RESULTS



METHODS
326 persons, 2.1% of whom were diagnosed of previously unknown DM2 and 7.3% of IFG. Insulin resistance (IR) was higher in patients with IFG and pancreatic function of beta cells (PFBC) was higher in the population without glucose metabolism alteration.


RESULTS
121 persons, 9.7 % of whom evolved to DM2 (all with IFG). IFG proportion at the end of the follow-up was 23.96%.


CONCLUSIONS
At 5 years of follow-up, more than 1/3 of the population studied developed DM2 or IFG. These diagnoses were related with IR and PFBC.
Vernet Vernet
M
M
Centro de Atención Primaria Terrassa Nord, Consorci Sanitari de Terrassa, Terrassa, Barcelona, España. mvernet@cst.cat
Sender Palacios
M J
MJ
Jovell Fernández
E
E
Casals Riera
R
R
Tor Figueras
E
E
Anglada Barceló
J
J
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D044882:Glucose Metabolism Disorders / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose