Effect of pre-transplant dialysis modality on kidney transplantation outcome.
BACKGROUND
The effect of pre-transplant dialysis modality on early graft function is a matter of debate. Although some authors deny the existence of a significant influence, others suggest that peritoneal dialysis (PD) affects early graft function favorably, possibly by contributing to a more physiologic water balance. In the present study, we evaluated the influence of pre-transplant dialysis modality on early and late graft function.


METHODS
We studied 745 patients who underwent a first renal transplantation during 1983-2006, comparing the records of 44 PD patients [26 male; mean age: 26 +/- 9 years (range: 8-56 years)] who received 36 living related and 8 cadaveric renal transplantations with those of a control group of 44 consecutive hemodialysis (HD) patients [26 male; mean age: 27 +/- 11 years (range: 7-49 years)] for the index cases.


RESULTS
The groups showed no significant differences in donor type, human leukocyte antigen matching, immunosuppressive protocols, and duration of dialysis. Also, neither group differed significantly with regard to incidence of delayed graft function, acute tubular necrosis, wound infection, systemic viral and bacterial infections, or acute rejection in the early post-transplant period. In the late post-transplant period, incidences of chronic rejection, graft failure, and malignancies were also similar. During the follow-up period, 3 patients in the PD group experienced acute rejection, 2 developed cytomegalovirus (CMV) disease, and 5 developed various other infections. In the HD group, 4 patients experienced acute rejection, 1 developed CMV disease, and 8 experienced other infections. Five patients in the PD group and one in the HD group died with functioning grafts (p = 0.09). No differences were noted between the groups in the incidences of post-transplant cardiovascular complications, malignancies, and diabetes mellitus. In the PD group, 33 patients with functioning grafts are still being followed, 6 have returned to dialysis, and 5 have died. In the HD group, 38 patients with functioning grafts are still being followed, 5 have returned to dialysis, and 1 has died.


CONCLUSIONS
As a pre-transplant dialysis modality, neither HD nor PD affects the outcome of renal transplantation.
Caliskan
Yasar
Y
Division of Nephrology, Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Istanbul, Turkey. ykcaliskan@yahoo.com
Yazici
Halil
H
Gorgulu
Numan
N
Yelken
Berna
B
Emre
Turker
T
Turkmen
Aydin
A
Yildiz
Alaattin
A
Aysuna
Nilgun
N
Bozfakioglu
Semra
S
Sever
Mehmet Sukru
MS
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D006435:Renal Dialysis / Q000379:methods*; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult