OCT4B1 isoform: the novel OCT4 alternative spliced variant as a putative marker of stemness.
A novel OCT4 alternative spliced variant (OCT 4B1) is deduced to be the isoform present in 59 hESC lines characterised by the International Stem Cell Initiative (ISCI) rather than OCT4A as previously assumed. The new variant may be a more reliable marker of stemness than OCT4A and studies are needed to test this.
Papamichos
Spyros I
SI
First Department of Obstetrics and Gynaecology, General Regional Hospital Papageorgiou, Aristotle University, Thessaloniki, Greece. spmedauth@yahoo.gr
Kotoula
Vassiliki
V
Tarlatzis
Basil C
BC
Agorastos
Theodoros
T
Papazisis
Konstantinos
K
Lambropoulos
Alexandros F
AF
D017398:Alternative Splicing; D015415:Biomarkers / Q000378:metabolism*; D002460:Cell Line; D053595:Embryonic Stem Cells / Q000378:metabolism*; D006801:Humans; D050814:Octamer Transcription Factor-3 / Q000235:genetics / Q000378:metabolism*; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers; D050814:Octamer Transcription Factor-3; D020033:Protein Isoforms