Efficacy of antivascular photodynamic therapy using benzoporphyrin derivative monoacid ring A (BPD-MA) in 14 dogs with oral and nasal tumors.
Antivascular photodynamic therapy (PDT) suppresses tumor growth and prolonged the survival in solid tumor-bearing mice. The purpose of this study was to assess the efficacy of antivascular PDT using BPD-MA for treatment of oral and nasal tumors in 14 dogs. At 15 min after initiating intravenous infusion of 0.5 mg/kg benzoporphyrin derivative monoacid ring A, tumors were irradiated with laser light at 690 nm emitted by a diode laser. The 1-year survival rate of 7 dogs with oral tumors was 71%. The 1-year survival rate of 7 dogs with nasal tumors was 57%. Imaging of each tumor was performed by using angiographic computed tomography before and after each antivascular PDT. Contrast-enhanced tumors were observed before antivascular PDT, but these tumors were not enhanced with contrast medium following antivascular PDT. Antivascular PDT is suggested to be a promising method for dogs with oral and nasal tumors that cannot be effectively treated with current antitumor therapies.
Osaki
Tomohiro
T
Laboratory of Veterinary Surgery, Department of Veterinary Clinical Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan. ohchan@vetmed.hokudai.ac.jp
Takagi
Satoshi
S
Hoshino
Yuki
Y
Okumura
Masahiro
M
Kadosawa
Tsuyoshi
T
Fujinaga
Toru
T
D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007262:Infusions, Intravenous / Q000662:veterinary; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000662:veterinary; D009669:Nose Neoplasms / Q000188:drug therapy* / Q000662:veterinary; D010778:Photochemotherapy / Q000379:methods* / Q000662:veterinary; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D011166:Porphyrins / Q000627:therapeutic use*; D016019:Survival Analysis; D014057:Tomography, X-Ray Computed; D000077362:Verteporfin
D017319:Photosensitizing Agents; D011166:Porphyrins; D000077362:Verteporfin