Geraniol restores antibiotic activities against multidrug-resistant isolates from gram-negative species.
The essential oil of Helichrysum italicum significantly reduces the multidrug resistance of Enterobacter aerogenes, Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii. Combinations of the two most active fractions of the essential oil with each other or with phenylalanine arginine beta-naphthylamide yield synergistic activity. Geraniol, a component of one fraction, significantly increased the efficacy of beta-lactams, quinolones, and chloramphenicol.
Lorenzi
Vannina
V
Université de la Méditerranée, UMR-MD1, IFR88, Faculté de Médecine, 13385 Marseille Cedex 05, France.
Muselli
Alain
A
Bernardini
Antoine François
AF
Berti
Liliane
L
Pagès
Jean-Marie
JM
Amaral
Leonard
L
Bolla
Jean-Michel
JM
D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D004357:Drug Synergism; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D036562:Helichrysum / Q000737:chemistry*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015363:Quinolones / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*; D047090:beta-Lactams / Q000494:pharmacology
D000080462:Acyclic Monoterpenes; D000900:Anti-Bacterial Agents; D004151:Dipeptides; D015363:Quinolones; D013729:Terpenes; D047090:beta-Lactams; C419365:phenylalanine arginine beta-naphthylamide; D002701:Chloramphenicol; C007836:geraniol