title: [Valuation of absorption of organic compounds in human body using liposome capillary electrophoresis].
abstract: Liposome capillary electrophoresis (LCE) was used as a model for the in vitro evaluation of the degree of membrane penetration of organic compounds. The hydrophobic parameters of 9 compounds were determined by LCE. In comparison of the correlation coefficient of log P(lw) (the logarithm of the partition coefficient of liposome/water system, calculated from retention factor) vs. log P(m) (the logarithm of osmotic coefficient) with that of log P(ow) (the logarithm of the partition coefficient of octanol/water system) vs. log P(m), the former was 0.94, much greater than the latter 0.78. It means that as the biomembrane model, liposome is more similar than the octanol/water system. The LCE method has the potential to be an in vitro screening model.
authors.affiliation: Department of Pharmaceutics, Institute of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China. wzcqdx002@163.com
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Zou
authors.forename: Honggui
authors.initials: H
authors.lastname: Jiang
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Dong
authors.forename: Zhining
authors.initials: Z
authors.lastname: Xia
authors.forename: Xuemei
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000042:Absorption; D002462:Cell Membrane / Q000378:metabolism; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008081:Liposomes / Q000378:metabolism*; D008954:Models, Biological; D009930:Organic Chemicals / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008081:Liposomes; D009930:Organic Chemicals