A new phenothiazine structural scaffold as inhibitors of bacterial quorum sensing in Vibrio harveyi.
Quorum sensing has attracted much attention due to its involvement in pathologically relevant events such as biofilm formation, virulence factor production, and sporulation. Inhibitors of quorum sensing are important research tools and potential therapeutic agents. In this paper, we describe a phenothiazine structural scaffold as a new type of quorum sensing inhibitors with IC(50) values in the single digit micro molar range in Vibrio harveyi.
Ni
Nanting
N
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Campus Box 4098, Atlanta, GA 30302-4098, USA.
Choudhary
Gaurav
G
Li
Minyong
M
Wang
Binghe
B
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001881:Borates / Q000494:pharmacology*; D010640:Phenothiazines / Q000737:chemistry / Q000494:pharmacology*; D053038:Quorum Sensing / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014733:Vibrio / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D001881:Borates; D010640:Phenothiazines; D015107:4-Butyrolactone