title: Bridgehead enolates and bridgehead alkenes in a welwistatin model series.
abstract: Bridgehead metallation is possible in a ketone having the welwistatin skeleton, and this facilitates installation of the isothiocyanate function present in the natural product, and also enables synthesis of remarkable bridgehead alkenes.
authors.affiliation: School of Chemistry, The University of Nottingham, University Park, Nottingham, UK NG7 2RD.
authors.forename: Valerie
authors.initials: V
authors.lastname: Boissel
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Simpkins
authors.forename: Gurdip
authors.initials: G
authors.lastname: Bhalay
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Blake
authors.forename: William
authors.initials: W
authors.lastname: Lewis
mesh_terms: D000470:Alkaloids / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D018360:Crystallography, X-Ray; D026121:Indole Alkaloids; D008958:Models, Molecular; D015394:Molecular Structure; D018036:Selenium Compounds / Q000737:chemistry; D064588:Selenium Oxides
chemical_list: D000470:Alkaloids; D000475:Alkenes; D026121:Indole Alkaloids; D018036:Selenium Compounds; D064588:Selenium Oxides; C092270:welwitindolinone C isothiocyanate