title: Continuous renal replacement therapy for refractory intracranial hypertension.
abstract: BACKGROUND
  Little is known about the effects of hemodialysis on the injured brain, however; concern exists over the use of intermittent hemodialysis in patients with acute brain injury (ABI) due to its hemodynamic effects and increased intracranial pressure (ICP) associated with therapy. Continuous renal replacement therapy (CRRT) has become the preferred method of renal support in these patients though there is limited data to support its safety. Furthermore, exacerbations of cerebral edema have been reported. CRRT is an option for the treatment of hypervolemia and in theory may improve intracranial compliance. We report the case of a poly-trauma patient with severe traumatic brain injury (TBI) in which CRRT was implemented solely for refractory intracranial hypertension.
  
  
  METHODS
  A 28-year-old male was involved in a high-speed motor vehicle collision suffering a severe TBI and polytrauma. He required significant volume resuscitation. Intensive care unit course was complicated by shock, acute respiratory distress syndrome, ventilator associated pneumonia, and development of intracranial hypertension (IH). Data were collected by retrospective chart review.
  
  
  RESULTS
  Continuous hemofiltration was initiated for IH refractory to medical therapy. Within hours of initiation increase, ICP improved and normalized. Hemofiltration was safely discontinued after 48 h. Modified Rankin Score was 2 at 90 days.
  
  
  CONCLUSIONS
  Though unproven, CRRT may be beneficial in patients with IH due to gentle removal of fluid, solutes, and inflammatory cytokines. Given the limited data on safety of CRRT in patients with ABI, we encourage further reports.
authors.affiliation: Department of Neurology (Neurocritical Care), Bronson Methodist Hospital, 601 John Street Suite M-124, Kalamazoo, MI 49007, USA. fletchej@bronsonhg.org
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Fletcher
authors.forename: Karen
authors.initials: K
authors.lastname: Bergman
authors.forename: Eric C
authors.initials: EC
authors.lastname: Feucht
authors.forename: Paul
authors.initials: P
authors.lastname: Blostein
mesh_terms: D000208:Acute Disease; D000328:Adult; D001810:Blood Volume; D001929:Brain Edema / Q000628:therapy; D001930:Brain Injuries / Q000628:therapy*; D003422:Critical Care; D006440:Hemofiltration; D006801:Humans; D019586:Intracranial Hypertension / Q000628:therapy*; D007427:Intracranial Pressure; D008297:Male; D017582:Renal Replacement Therapy / Q000379:methods*