title: Interventional sialendoscopy for treatment of radioiodine-induced sialadenitis.
abstract: OBJECTIVE
  The purpose of this study is to review our experience with sialendoscopy for the management of radioiodine-induced sialadenitis.
  
  
  METHODS
  Retrospective chart review of all patients with radioiodine-induced sialadenitis treated with interventional sialendoscopy.
  
  
  RESULTS
  Twelve female patients with a mean age of 46.5 years (range, 25-77 years) underwent interventional sialendoscopy for the treatment of recalcitrant sialadenitis from radioiodine-induced damage to the major salivary glands. Symptoms arising from the parotid gland were seen in 75% of patients, whereas symptoms arising from the submandibular gland were seen in 50%. Three patients (25%) presented symptoms in both the parotids and the submandibular glands. The mean dose of radioiodine was 143 mCi (range, 101.9-185.7 mCi) received as a single dose prior to their referral. The mean duration from radioiodine ablation therapy to sialendoscopy was 10.4 months (range, 5-16 months). Thirty-two glands (20 parotid, 12 submandibular) were taken to the operating room, with complete endoscopy successful in 27 glands (84.4%). Ductal stenosis (30%) and mucus plugs (44%) were the most common types of ductal pathology. Sialendoscopy improved the symptoms in 75% (9/12) of patients, with no serious complications reported in follow-up ranging from 2 weeks to 33 months (median, 6 months).
  
  
  CONCLUSIONS
  Interventional sialendoscopy is an effective tool for the management of patients with radioiodine-induced sialadenitis that is unresponsive to medical management.
authors.affiliation: Department of Otolaryngology and Head Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Bomeli
authors.forename: Barry
authors.initials: B
authors.lastname: Schaitkin
authors.forename: Ricardo L
authors.initials: RL
authors.lastname: Carrau
authors.forename: Rohan R
authors.initials: RR
authors.lastname: Walvekar
mesh_terms: D000328:Adult; D000368:Aged; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies; D012469:Salivary Glands / Q000528:radiation effects*; D012793:Sialadenitis / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*; D013964:Thyroid Neoplasms / Q000532:radiotherapy; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes