Pouchitis: an evolving clinical enigma--a review.
While the overall incidence of pouchitis is low, extensive research continues at clinical and experimental levels in attempts to unravel its etiology. The ileal pouch and pouchitis together represent a unique in vivo opportunity to study mucosal adaptation and inflammation in depth. In the recent past, molecular data relating to pouchitis has significantly expanded. These data provide invaluable insight into intracellular and extracellular events that underpin mucosal adaptation and inflammation. Advances in classification, risk factor evaluation, and prevention have meant that a review of this data, as well as its relationship to our current understanding of pouchitis, is both timely and warranted. Therefore, the aim of this review is to summarize recent data in the context of the established literature.
Coffey
John Calvin
JC
Department of Academic Surgery, Cork University Hospital, Cork, Ireland. calvincoffey@hotmail.com
McCarthy
Eoghan
E
Kavanagh
Eamon
E
Redmond
Henry Paul
HP
Kirwan
William Oliver
WO
D000818:Animals; D039021:Colonic Pouches / Q000009:adverse effects; D006801:Humans; D019449:Pouchitis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000628:therapy; D012307:Risk Factors