Specificity of systemic inflammatory response syndrome during the peri-operative period in patients with GH-secreting adenoma.
OBJECTIVE
To analyze the differences in systemic inflammatory responses (SIRS) during the peri-operative period following pituitary surgery, patients with pituitary adenomas were studied.


METHODS
There were three patient groups: group A consisted of 30 patients with GH-secreting adenoma, group B consisted of 20 age-matched patients with Cushing's disease, and group C consisted of 30 patients with other kinds of pituitary adenoma. Levels of white blood cells, C-reactive protein (CRP) and IL-6 in peripheral blood, as well as vital signs, were measured before and after operation.


RESULTS
Leucocytosis in peri-operative period was significantly milder in group A patients compared with either group B or C patients. The CRP level was significantly higher in both group B and group C patients than in group A patients. SIRS was observed in 17% of the cases in group A; by contrast, it was found in 55%, and 33% of the cases in group B, and in group C, respectively.


CONCLUSIONS
The inflammatory reaction to surgical trauma is milder in patients with GH-secreting adenomas than in patients with other kinds of pituitary adenoma.
Ikeda
Hidetoshi
H
Department of Neurosurgery, Ohara Medical Center, Fukushima City, Japan.
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D015850:Interleukin-6 / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D007964:Leukocytosis / Q000097:blood; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism; D010907:Pituitary Hormones / Q000097:blood; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000601:surgery*; D018746:Systemic Inflammatory Response Syndrome / Q000378:metabolism*
D015850:Interleukin-6; D010907:Pituitary Hormones; D019382:Human Growth Hormone; D002097:C-Reactive Protein