title: Vertical and horizontal integrator failure in a ponto-medullary infarction: A possible role for paramedian tract neurons.
abstract: Gaze-evoked nystagmus is caused by a "leaky" neural integrator, which fails to maintain eccentric gaze positions after centrifugal eye movements. It is usually observed as the result of toxic, metabolic or paraneoplastic disorders, rather than single structural lesions. We demonstrate a case of an omnidirectional gaze-evoked nystagmus due to an ischemic paramedian ponto-medullar infarction. The most probable explanation is a damage of paramedian tract neurons, which have been recently recognized as a site of neural integration.
authors.affiliation: Department of Neurology, Eginition Hospital, University of Athens, Vas. Sophias Avenue 74, 11528 Athens, Greece. granavan@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Anagnostou
authors.forename: K
authors.initials: K
authors.lastname: Spengos
authors.forename: S
authors.initials: S
authors.lastname: Margeti
authors.forename: S
authors.initials: S
authors.lastname: Vassilopoulou
authors.forename: G P
authors.initials: GP
authors.lastname: Paraskevas
authors.forename: V
authors.initials: V
authors.lastname: Zis
mesh_terms: D001933:Brain Stem / Q000473:pathology; D020526:Brain Stem Infarctions / Q000150:complications* / Q000473:pathology; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009760:Nystagmus, Physiologic; D015835:Ocular Motility Disorders / Q000209:etiology* / Q000523:psychology; D014741:Video Recording