Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones.
Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this synthesis.
Heravi
Majid M
MM
Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran. mmh1331@yahoo.com
Baghernejad
Bita
B
Oskooie
Hossein A
HA
D000447:Aldehydes / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D003500:Cyclization; D003510:Cyclohexanes / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D055772:Green Chemistry Technology / Q000379:methods*; D007189:Indans / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry*
D000447:Aldehydes; D003486:Cyanides; D003510:Cyclohexanes; D005663:Furans; D007189:Indans; D014867:Water; C001445:1,3-indandione