Purinergic regulation of glomerular microvasculature and tubular function.
Purinergic molecules: ATP, ADP and adenosine regulate physiological processes through activation of purinoceptors in the plasma membrane. Experimental evidence supports the view that purinergic molecules affect glomerular and tubular functions. Purinergic molecule-induced changes of tension of mesangial cells and/or podocytes may influence GFR by affecting the glomerular ultrafiltration coefficient. On the other hand, purinoceptors are crucial for electrolyte and fluid homeostasis by modulating activity of sodium-potassium-ATPase, voltage-independent or -dependent ion channels and cAMP-dependent water channels.
Jankowski
M
M
Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdansk, Poland. majank@amg.gda.pl
D000241:Adenosine / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004573:Electrolytes / Q000378:metabolism; D005919:Glomerular Filtration Rate / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008833:Microcirculation; D011983:Receptors, Purinergic / Q000378:metabolism
D004573:Electrolytes; D011983:Receptors, Purinergic; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000241:Adenosine