Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
Duque
María D
MD
Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Diagonal, 643, Barcelona E-08028, Spain.
Camps
Pelayo
P
Profire
Lenuta
L
Montaner
Silvia
S
Vázquez
Santiago
S
Sureda
Francesc X
FX
Mallol
Jordi
J
López-Querol
Marta
M
Naesens
Lieve
L
De Clercq
Erik
E
Prathalingam
S Radhika
SR
Kelly
John M
JM
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D018929:Cell Culture Techniques; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000494:pharmacology
D000588:Amines; D000998:Antiviral Agents; D016194:Receptors, N-Methyl-D-Aspartate; D014344:Trypanocidal Agents; D000218:Adamantane