title: Increasing invasive disease due to penicillin resistant S. pneumoniae in India.
abstract: S. pneumoniae continues to be a major cause of invasive disease worldwide with considerable mortality and morbidity. Here we report the emergence of penicillin intermediate resistance to S. pneumoniae in India, which may predispose for an increased incidence of invasive pneumococcal disease in both children and adults with multi-drug resistance profile resulting in clinical failure.
authors.affiliation: Department of Clinical Microbiology, Christian Medical College, Vellore, India. vbalaji@cmcvellore.ac.in
authors.forename: Veeraraghavan
authors.initials: V
authors.lastname: Balaji
authors.forename: Kurien
authors.initials: K
authors.lastname: Thomas
authors.forename: Hari Har
authors.initials: HH
authors.lastname: Joshi
authors.forename: Bernard
authors.initials: B
authors.lastname: Beall
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007194:India; D008297:Male; D010068:Oxacillin / Q000494:pharmacology; D010403:Penicillin Resistance; D013290:Streptococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013296:Streptococcus pneumoniae / Q000187:drug effects / Q000302:isolation & purification*; D014640:Vancomycin / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D002443:Ceftriaxone; D010068:Oxacillin