title: Stroop-test interference in bipolar disorder.
abstract: We analysed Stroop (neuropsychological screening test) measures of response inhibition in 18 twin pairs discordant for bipolar I disorder compared with 17 healthy control pairs, as well as 40 singletons with bipolar disorder with psychotic features and a family history of psychosis, 46 of their first-degree relatives without bipolar disorder or psychosis and 48 controls. In both studies, individuals with bipolar disorder showed Stroop deficits and their first-degree relatives showed intact performance. In the twin patients, an interference score was associated with depressive symptoms. Having a first-degree relative with bipolar disorder, even a familial, psychotic form, did not confer risk for enhanced susceptibility to interference in our studies.
authors.affiliation: Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. e.kravariti@iop.kcl.ac.uk
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kravariti
authors.forename: Katja
authors.initials: K
authors.lastname: Schulze
authors.forename: Fergus
authors.initials: F
authors.lastname: Kane
authors.forename: Sridevi
authors.initials: S
authors.lastname: Kalidindi
authors.forename: Elvira
authors.initials: E
authors.lastname: Bramon
authors.forename: Muriel
authors.initials: M
authors.lastname: Walshe
authors.forename: Nicolette
authors.initials: N
authors.lastname: Marshall
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Hall
authors.forename: Anna
authors.initials: A
authors.lastname: Georgiades
authors.forename: Colm
authors.initials: C
authors.lastname: McDonald
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000523:psychology; D006801:Humans; D009483:Neuropsychological Tests; D010375:Pedigree; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology