Activation of hemiaminal ethers by chiral Brønsted acids for facile access to enantioselective two-carbon homologation using enecarbamates.
An enriching experience: Chiral phosphoric acids have been used to catalyze the title transformation for aromatic and aliphatic hemiaminal ethers. The process affords the corresponding products in good to high enantioselectivity (see scheme; Boc = tert-butoxycarbonyl, G = aromatic group). The method enables facile access to highly enantioenriched 1,3-diamine derivatives.
Terada
Masahiro
M
Department of Chemistry, Graduate School of Scienece, Tohoku University, Aramaki, Aoba-ku, Sendai 980-8578, Japan. mterada@mail.tains.tohoku.ac.jp
Machioka
Kyoko
K
Sorimachi
Keiichi
K