title: In DNA replication, the early bird catches the worm.
abstract: The initiation of DNA replication is a complex, multistep process with important implications for genomic stability. In this issue, Wu and Nurse (2009) find that initiation factors are differentially recruited to replication origins. They uncover evidence suggesting that the efficiency of this recruitment may determine whether and when an origin is used to initiate DNA replication in S phase.
authors.forename: Erik
authors.initials: E
authors.lastname: Boye
authors.forename: Beáta
authors.initials: B
authors.lastname: Grallert
mesh_terms: D004261:DNA Replication; D004271:DNA, Fungal / Q000235:genetics; D042822:Genomic Instability; D018741:Replication Origin; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism
chemical_list: D004271:DNA, Fungal; D029702:Schizosaccharomyces pombe Proteins