Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer.
The p53 protein is critical for multiple cellular functions including cell growth and DNA repair. We assessed whether polymorphisms in the region encoding TP53 were associated with risk of invasive ovarian cancer. The study population includes a total of 5,206 invasive ovarian cancer cases (2,829 of which were serous) and 8,790 controls from 13 case-control or nested case-control studies participating in the Ovarian Cancer Association Consortium (OCAC). Three of the studies performed independent discovery investigations involving genotyping of up to 23 single nucleotide polymorphisms (SNP) in the TP53 region. Significant findings from this discovery phase were followed up for replication in the other OCAC studies. Mixed effects logistic regression was used to generate posterior median per allele odds ratios (OR), 95% probability intervals (PI), and Bayes factors (BF) for genotype associations. Five SNPs showed significant associations with risk in one or more of the discovery investigations and were followed up by OCAC. Mixed effects analysis confirmed associations with serous invasive cancers for two correlated (r(2) = 0.62) SNPs: rs2287498 (median per allele OR, 1.30; 95% PI, 1.07-1.57) and rs12951053 (median per allele OR, 1.19; 95% PI, 1.01-1.38). Analyses of other histologic subtypes suggested similar associations with endometrioid but not with mucinous or clear cell cancers. This large study provides statistical evidence for a small increase in risk of ovarian cancer associated with common variants in the TP53 region.
Schildkraut
Joellen M
JM
Comprehensive Cancer Center, Department of Community and Family Medicine, Duke University Medical Center, and Department of Statistical Science, Duke University, Durham, North Carolina, USA. schil001@mc.duke.edu
Goode
Ellen L
EL
Clyde
Merlise A
MA
Iversen
Edwin S
ES
Moorman
Patricia G
PG
Berchuck
Andrew
A
Marks
Jeffrey R
JR
Lissowska
Jolanta
J
Brinton
Louise
L
Peplonska
Beata
B
Cunningham
Julie M
JM
Vierkant
Robert A
RA
Rider
David N
DN
Chenevix-Trench
Georgia
G
Webb
Penelope M
PM
Beesley
Jonathan
J
Chen
Xiaoqing
X
Phelan
Catherine
C
Sutphen
Rebecca
R
Sellers
Thomas A
TA
Pearce
Leigh
L
Wu
Anna H
AH
Van Den Berg
David
D
Conti
David
D
Elund
Christopher K
CK
Anderson
Rebecca
R
Goodman
Marc T
MT
Lurie
Galina
G
Carney
Michael E
ME
Thompson
Pamela J
PJ
Gayther
Simon A
SA
Ramus
Susan J
SJ
Jacobs
Ian
I
Krüger Kjaer
Susanne
S
Hogdall
Estrid
E
Blaakaer
Jan
J
Hogdall
Claus
C
Easton
Douglas F
DF
Song
Honglin
H
Pharoah
Paul D P
PD
Whittemore
Alice S
AS
McGuire
Valerie
V
Quaye
Lydia
L
Anton-Culver
Hoda
H
Ziogas
Argyrios
A
Terry
Kathryn L
KL
Cramer
Daniel W
DW
Hankinson
Susan E
SE
Tworoger
Shelley S
SS
Calingaert
Brian
B
Chanock
Stephen
S
Sherman
Mark
M
Garcia-Closas
Montserrat
M
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D016158:Genes, p53; D020022:Genetic Predisposition to Disease; D006801:Humans; D015810:Linkage Disequilibrium; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult