D2R striatopallidal neurons inhibit both locomotor and drug reward processes.
The specific functions of dopamine D(2) receptor-positive (D(2)R) striatopallidal neurons remain poorly understood. Using a genetic mouse model, we found that ablation of D(2)R neurons in the entire striatum induced hyperlocomotion, whereas ablation in the ventral striatum increased amphetamine conditioned place preference. Thus D(2)R striatopallidal neurons limit both locomotion and, unexpectedly, drug reinforcement.
Durieux
Pierre F
PF
Laboratory of Neurophysiology, Université Libre de Bruxelles, Brussels, Belgium.
Bearzatto
Bertrand
B
Guiducci
Stefania
S
Buch
Thorsten
T
Waisman
Ari
A
Zoli
Michele
M
Schiffmann
Serge N
SN
de Kerchove d'Exaerde
Alban
A
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001345:Autoradiography; D003216:Conditioning, Operant / Q000502:physiology; D003342:Corpus Striatum / Q000166:cytology*; D004167:Diphtheria Toxin / Q000494:pharmacology; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology; D004745:Enkephalins / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects / Q000235:genetics; D005917:Globus Pallidus / Q000166:cytology*; D005968:Glutamate Decarboxylase / Q000235:genetics / Q000378:metabolism; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics; D008124:Locomotion / Q000187:drug effects / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011485:Protein Binding / Q000187:drug effects; D043683:Receptors, Adenosine A2 / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000172:deficiency / Q000378:metabolism*; D012055:Reinforcement Schedule; D012201:Reward; D013997:Time Factors; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics / Q000378:metabolism
D004167:Diphtheria Toxin; D018765:Dopamine Uptake Inhibitors; D004745:Enkephalins; C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D043683:Receptors, Adenosine A2; D017448:Receptors, Dopamine D2; D000661:Amphetamine; D014446:Tyrosine 3-Monooxygenase; D005968:Glutamate Decarboxylase; C402565:glutamate decarboxylase 1