Pharmacological effects and behavioral interventions on memory consolidation and reconsolidation.
In this article, we will review some behavioral, pharmacological and neurochemical studies from our laboratory on mice, which might contribute to our understanding of the complex processes of memory consolidation and reconsolidation. We discuss the post-training (memory consolidation) and post-reactivation (memory reconsolidation) effects of icv infusions of hemicholinium, a central inhibitor of acetylcholine synthesis, of intraperitoneal administration of L-NAME, a non-specific inhibitor of nitric oxide synthase, of intrahippocampal injections of an inhibitor of the transcription factor NF-kappaB, and the exposure of mice to a new learning situation on retention performance of an inhibitory avoidance response. All treatments impair long-term memory consolidation and retrieval-induced memory processes different from extinction, probably in accordance with the 'reconsolidation hypothesis'.
Baratti
C M
CM
Laboratorio de Neurofarmacología de los Procesos de Memoria, Cátedra de Farmacología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Buenos Aires, Argentina. cbaratti@ffyb.uba.ar
Boccia
M M
MM
Blake
M G
MG
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D006426:Hemicholinium 3 / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D016328:NF-kappa B / Q000494:pharmacology*; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology
D016328:NF-kappa B; D006426:Hemicholinium 3; D019001:Nitric Oxide Synthase; D000109:Acetylcholine; D019331:NG-Nitroarginine Methyl Ester