title: [Experimental study on antitumor effect of extracts from Cestrum nocturnum in vivo].
abstract: OBJECTIVE
  To observe the antitumor effects of extracts from Cestrum nocturnum (CN) in vivo.
  
  
  METHODS
  The S180-mice model was used to observe the tumor-inhibition rate of CN and the H22-mice model was used to test the survival time.
  
  
  RESULTS
  The experiment in S180-mice demonstrated that the n-butanol and polysaccharides extracts from CN had obvious effects on tumor inhibition. Its inhibitory rates were 52.30%, 46.75%, 42.28%, 43.19%, 37.96% and 31.82% respectively in the mice administrated the n-butanol and polysaccharides extracts from CN with 30 mg/kg, 20 mg/kg and 15 mg/kg weight dosage. It was noted that tumor formation postponed in mice treated with the n-butanol and polysaccharides extracts from CN compared with the control panel and tumor growth became slower; The n-butanol and polysaccharides extracts from CN could also greatly enhance the life span of mice with H22 ascitic tumors by 116.43%, 44.52%, 20.54%, 109.52%, 112.61% and 115.01%, respectively. The inhibit effects of n-butanol fraction extracts from CN had direct relationship with dose, while the polysaccharides fraction extracts from CN had no obvious relationship with dose.
  
  
  CONCLUSIONS
  The n-butanol and polysaccharides extracts of CN are able to inhibit tumor growth and prolong the lifetime of the tumor-bearing mice in a dose-dependent pattern.
authors.affiliation: New Drug Development Center of University of Traditional Chinese Medicine, Nanning 530001, China. zhongzg@gxtcmu.edu.cn
authors.forename: Zhen-Guo
authors.initials: ZG
authors.lastname: Zhong
authors.forename: Shi-Yuan
authors.initials: SY
authors.lastname: Zhao
authors.forename: Jin-Yan
authors.initials: JY
authors.lastname: Lv
authors.forename: Peng
authors.initials: P
authors.lastname: Li
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology; D045744:Cell Line, Tumor; D032301:Cestrum / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D012510:Sarcoma 180 / Q000188:drug therapy / Q000473:pathology*; D015996:Survival Rate
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal