title: Expression and prognostic significance of CK19 in canine malignant mammary tumours.
abstract: Expression of the luminal cytokeratin CK19 was examined in 102 canine mammary carcinomas by immunohistochemical analysis and associated with known expression of oestrogen receptor (ER), basal/myoepithelial cell markers, proliferation and survival. Negative staining for CK19 was present in 23.5% of tumours and was associated with histological type, grade, invasiveness, Ki67 index and expression of basal/myoepithelial cell markers. Positive staining for CK19 was associated with ER expression. Reduced expression of CK19 was associated with both shorter overall and disease-free survival rates; however, CK19 was not an independent prognostic factor in multivariate analysis. Reduced expression of CK19 in canine mammary carcinomas is related to an aggressive phenotype and may play a role in tumour progression.
authors.affiliation: Department of Veterinary Sciences, CECAV, University of Trás-os-Montes and Alto Douro, 5001-811 Vila Real, Portugal.
authors.forename: Adelina
authors.initials: A
authors.lastname: Gama
authors.forename: Anabela
authors.initials: A
authors.lastname: Alves
authors.forename: Fernando
authors.initials: F
authors.lastname: Schmitt
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D002454:Cell Differentiation; D018572:Disease-Free Survival; D004283:Dog Diseases / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D053539:Keratin-19 / Q000235:genetics / Q000378:metabolism*; D015674:Mammary Neoplasms, Animal / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D053539:Keratin-19; D011960:Receptors, Estrogen