Ovarian cancer: pathology, biology, and disease models.
Epithelial ovarian cancer, which comprises several histologic types and grades, is the most lethal cancer among women in the United States. In this review, we summarize recent progress in understanding the pathology and biology of this disease and in development of models for preclinical research. Our new understanding of this disease suggests new targets for therapeutic intervention and novel markers for early detection of disease.
Rosen
Daniel G
DG
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77005-4095, USA.
Yang
Gong
G
Liu
Guangzhi
G
Mercado-Uribe
Imelda
I
Chang
Bin
B
Xiao
Xue Sherry
XS
Zheng
Jingfang
J
Xue
Feng-Xia
FX
Liu
Jinsong
J
D005260:Female; D005801:Genes, Homeobox; D006801:Humans; D010051:Ovarian Neoplasms / Q000145:classification / Q000235:genetics / Q000473:pathology*