NW-G01, a novel cyclic hexadepsipeptide antibiotic, produced by Streptomyces alboflavus 313: I. Taxonomy, fermentation, isolation, physicochemical properties and antibacterial activities.
NW-G01, a novel cyclic hexadepsipeptide antibiotic, was isolated by macroporous resin and silica gel column chromatography and HPLC from the fermentation broth of strain no. 313. The producing strain was identified as Streptomyces alboflavus on the basis of the morphological characteristics, physiological property and 16S rDNA gene sequence analysis. NW-G01 exhibited strong antibacterial activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, methicillin-resistant S. aureus, and their MIC values were 3.90, 3.90, 7.81 and 7.81 microg ml(-1), respectively.
Guo
Zhengyan
Z
Institute of Pesticide Science, Northwest Agricultural & Forestry University, Shaanxi, China.
Shen
Ling
L
Ji
Zhiqin
Z
Zhang
Jiwen
J
Huang
Luzhi
L
Wu
Wenjun
W
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D003470:Culture Media; D047630:Depsipeptides / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D047630:Depsipeptides; C544293:NW-G01