High dose of red wine elicits enhanced inhibition of fibrinolysis.
METHODS
The purpose of this randomized controlled cross-over study was to determine the acute effects of high doses of alcoholic beverages on circulating markers related to atherosclerosis and fibrinolysis.


METHODS
Twenty-two healthy men consumed a high dose (8.1+/-0.9 dl) of alcohol-containing red wine and dealcoholized red wine, and an equal ethanol dose of cognac (2.4+/-0.3 dl). Blood samples were taken before and shortly after interventions.


RESULTS
Red wine, unlike dealcoholized red wine and cognac, increased tissue plasminogen activator inhibitor-1 levels significantly, indicating an acute inhibition of fibrinolysis after a high dose.


CONCLUSIONS
Findings may explain the increased risk of cardiovascular mortality among binge drinkers.
Kiviniemi
Tuomas O
TO
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. tuoski@utu.fi
Saraste
Antti
A
Lehtimäki
Terho
T
Toikka
Jyri O
JO
Saraste
Markku
M
Raitakari
Olli T
OT
Pärkkä
Jussi P
JP
Hartiala
Jaakko J
JJ
Viikari
Jorma
J
Koskenvuo
Juha W
JW
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D018592:Cross-Over Studies; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D014920:Wine / Q000009:adverse effects*; D055815:Young Adult
D015415:Biomarkers; D018836:Inflammation Mediators; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D000431:Ethanol