A novel twist to protein secretion in eukaryotes.
A recent functional analysis of the protein translocase, which is present in the trypanosomal endoplasmic reticulum membrane, by Michaeli and co-workers has indicated an unexpected diversity in the mechanisms and components of protein secretion in eukaryotes and might eventually pave the way for the development of anti-trypanosomal drugs. Furthermore, the work on these human parasites also supports conclusions that were drawn previously for components of protein secretion in human cells on the basis of in vitro studies.
Zimmermann
Richard
R
Medical Biochemistry and Molecular Biology, Saarland University, 66421 Homburg, Germany. bcrzim@uks.eu
Blatch
Gregory L
GL
D000818:Animals; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism*; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D010458:Peptidyl Transferases / Q000378:metabolism*; D021382:Protein Sorting Signals; D021381:Protein Transport
D021382:Protein Sorting Signals; D010458:Peptidyl Transferases