title: Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications.
abstract: To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM x HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infrared spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r(2) and coronal image of the crossing of mouse kidney.
authors.affiliation: College of New Drug Innovation Research & Development, East China Normal University, Shanghai 200062, PR China.
authors.forename: Yanbao
authors.initials: Y
authors.lastname: Gong
authors.forename: Mingxia
authors.initials: M
authors.lastname: Fan
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Jun
authors.initials: J
authors.lastname: Hong
authors.forename: Shunying
authors.initials: S
authors.lastname: Liu
authors.forename: Shufang
authors.initials: S
authors.lastname: Luo
authors.forename: Jiahui
authors.initials: J
authors.lastname: Yu
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
mesh_terms: D000588:Amines / Q000737:chemistry*; D000818:Animals; D005290:Ferric Compounds / Q000737:chemistry; D007668:Kidney / Q000033:anatomy & histology; D008027:Light; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D051379:Mice; D000080385:Nanogels; D053758:Nanoparticles / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012542:Scattering, Radiation; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013997:Time Factors
chemical_list: D000588:Amines; D005290:Ferric Compounds; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; C000499:ferric oxide; D011092:Polyethylene Glycols; D011094:Polyethyleneimine