title: Unsymmetrically disubstituted urea derivatives: a potent class of antiglycating agents.
abstract: A series of unsymmetrically disubstituted urea derivatives 1-28 has been synthesized and screened for their antiglycation activity in vitro. Compounds 26 (IC(50)=4.26+/-0.25 microM), 1 (IC(50)=5.8+/-0.08 microM), 22 (IC(50)=4.26+/-0.25 microM), 6 (IC(50)=6.4+/-0.02 microM), 5 (IC(50)=6.6+/-0.26 microM), 2 (IC(50)=7.02+/-0.31 microM), 3 (IC(50)=7.14+/-0.84 microM), 27 (IC(50)=7.27+/-0.36 microM), 4 (IC(50)=8.16+/-1.04 microM), 21 (IC(50)=8.4+/-0.15 microM), 23 (IC(50)=9.0+/-0.35 microM) and 13 (IC(50)=15.22+/-6.7 microM) showed an excellent antiglycation activity far better than the standard (rutin, IC(50)=41.9+/-2.3 microM). This study thus provides a series of potential molecules for further studies of antiglycation agents.
authors.affiliation: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. khalid.khan@iccs.edu
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Khan
authors.forename: Sumayya
authors.initials: S
authors.lastname: Saeed
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ali
authors.forename: Madiha
authors.initials: M
authors.lastname: Gohar
authors.forename: Javariya
authors.initials: J
authors.lastname: Zahid
authors.forename: Ambreen
authors.initials: A
authors.lastname: Khan
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D005947:Glucose / Q000037:antagonists & inhibitors* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D014508:Urea; D005947:Glucose