title: Spontaneous lysosomal storage disease caused by Sida carpinifolia (Malvaceae) poisoning in cattle.
abstract: Clinical and pathologic findings for the spontaneous poisoning by Sida carpinifolia in cattle are described in this study. A survey on field cases of S. carpinifolia in cattle was carried out on farms of Alto Vale do Itajaí, State of Santa Catarina, southern Brazil. Sixteen affected animals were clinically evaluated and 9 were subjected to postmortem examination. The main clinical signs consisted of marching gait, alert gaze, head tremors, and poor growth. Histologic and ultrastructural lesions consisted of vacuolization and distension of neuronal perikarya, mainly from Purkinje cells, and of the cytoplasm of acinar pancreatic and thyroid follicular cells. Clinical signs and lesions varied from mild to severe. Improvement of the clinical signs was observed in cattle after a period of up to 90 days without consuming the plant; however, residual lesions, mainly characterized by axonal spheroids and absence of Purkinje neurons in some areas of the cerebellum, were observed in these cases. It is concluded that the natural chronic consumption of S. carpinifolia was the etiologic cause of storage disease in cattle in this study.
authors.affiliation: Laboratory of Animal Pathology, Santa Catarina State University, Av. Luís de Camões 2090, Lages-SC, Brazil.
authors.forename: F H
authors.initials: FH
authors.lastname: Furlan
authors.forename: J
authors.initials: J
authors.lastname: Lucioli
authors.forename: L O
authors.initials: LO
authors.lastname: Veronezi
authors.forename: A L
authors.initials: AL
authors.lastname: Medeiros
authors.forename: S S
authors.initials: SS
authors.lastname: Barros
authors.forename: S D
authors.initials: SD
authors.lastname: Traverso
authors.forename: A
authors.initials: A
authors.lastname: Gava
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced*; D002531:Cerebellum / Q000473:pathology; D016464:Lysosomal Storage Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D019660:Malvaceae / Q000506:poisoning*; D010939:Plant Poisoning / Q000473:pathology / Q000662:veterinary; D013961:Thyroid Gland / Q000473:pathology