Factors associated with HIV-1 proviral DNA loads in patients with undetectable plasma RNA load.
To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1-infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/microL without highly active antiretroviral therapy (HAART) was significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/microL without HAART could help reduce HIV-1 proviral DNA load.
Choi
Jun Yong
JY
Department of Internal Medicine and AIDS Research Institute, BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
Song
Young Goo
YG
Kim
Young Hwa
YH
Kim
Chang Oh
CO
Kim
Myung Soo
MS
Chin
Bum Sik
BS
Han
Sang Hoon
SH
Choi
Suk Hoon
SH
Lee
Han Sung
HS
Jeong
Su Jin
SJ
Choi
Heekyoung
H
Kim
June Myung
JM
D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000235:genetics*; D012367:RNA, Viral / Q000097:blood
D019380:Anti-HIV Agents; D004279:DNA, Viral; D012367:RNA, Viral