title: Association between manganese superoxide dismutase (MnSOD) gene polymorphism and elderly obesity.
abstract: Evidence suggests an association between obesity and oxidative stress caused by superoxide production. Since the dismutation of superoxide is catalyzed by superoxide dismutase enzymes, we tested the association between obesity and Ala16Val manganese-dependent superoxide dismutase gene (MnSOD) polymorphism. We analyzed 815 free-living community subjects (> or =60 years old) grouped into subjects who were either obese (BMI > or = 30 kg/m(2)) or non-obese (BMI < 25 kg/m(2)). Additionally, we investigated the possible interaction between the Ala16Val MnSOD gene polymorphism and obesity in the modulation of biochemical and nutritional variables. We found a positive association between MnSOD polymorphism and obesity, since higher VV frequency (28.2%) was observed in the obese group (P = 0.002, odds ratio 1.949, 95% CI: 1.223-3.008). This result was independent of sex, age, diabetes, dyslipidemia, hypertension, and metabolic syndrome. A possible biological explanation of the association described here could be a chronic state of superoxide enzyme imbalance present in VV carriers, which could affect differential metabolic pathways contributing to the obese state.
authors.affiliation: Departamento de Ciencias Biomedicas, Universidad de Leon, Spain.
authors.forename: Marco Aurélio Echart
authors.initials: MA
authors.lastname: Montano
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Barrio Lera
authors.forename: Maria Gabriela Valle
authors.initials: MG
authors.lastname: Gottlieb
authors.forename: Carla Helena Augustin
authors.initials: CH
authors.lastname: Schwanke
authors.forename: Maria Izabel Ugalde Marques
authors.initials: MI
authors.lastname: da Rocha
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Manica-Cattani
authors.forename: Greice Feyl
authors.initials: GF
authors.lastname: dos Santos
authors.forename: Ivana Beatrice Manica
authors.initials: IB
authors.lastname: da Cruz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D009752:Nutritional Status; D009765:Obesity / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D013482:Superoxide Dismutase