title: Severe hyponatraemia in the setting of hypopituitarism associated with empty sella and herniation of the optic chiasm and gyrus rectus.
abstract: We present a patient with progressive weakness over months caused by untreated hyponatraemia. When hyponatraemia became severe, the patient could not move without help, was lethargic and had endocrinological dysfunction. Symptomatic therapy brought no improvement. MRI of the brain showed empty sella with gross herniation of the optic chiasma, gyrus rectus and third ventricle. After fluid and salt supplementation was combined with hydrocortisone, the patient regained his strength and could leave the hospital. Panhypopituitarism caused by empty sella should always be considered when hyponatraemia is not responsive to salt and fluid substitution alone. Additional hydrocortisone supplementation can be life saving.
authors.affiliation: Department of Neurosurgery, University Hospital of Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 10, 24105 Kiel, Germany. opticdisc@aol.com
authors.forename: Athanasios K
authors.initials: AK
authors.lastname: Petridis
authors.forename: Arya
authors.initials: A
authors.lastname: Nabavi
authors.forename: Alexandros
authors.initials: A
authors.lastname: Doukas
authors.forename: Ralf
authors.initials: R
authors.lastname: Buhl
authors.forename: Hubertus-Maximilian
authors.initials: HM
authors.lastname: Mehdorn
mesh_terms: D000368:Aged; D004652:Empty Sella Syndrome / Q000150:complications*; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D007010:Hyponatremia / Q000150:complications*; D007018:Hypopituitarism / Q000150:complications*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009897:Optic Chiasm / Q000473:pathology*; D020542:Third Ventricle / Q000473:pathology