Bioactive alkaloids from endophytic Aspergillus fumigatus.
Two new alkaloids, named 9-deacetylfumigaclavine C (1) and 9-deacetoxyfumigaclavine C (2), along with 12 known compounds (3-14), were isolated from the culture of Aspergillus fumigatus. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compound 2 showed selectively potent cytotoxicity against human leukemia cells (K562) with an IC(50) value of 3.1 microM, which was comparable to that of doxorubicin hydrochloride, a presently prescribed drug for the treatment of leukemia. Furthermore, 14-norpseurotin (4) significantly induced neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration.
Ge
Hui Ming
HM
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.
Yu
Zhi Guo
ZG
Zhang
Jie
J
Wu
Jun Hua
JH
Tan
Ren Xiang
RX
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000737:chemistry*; D031744:Cynodon / Q000382:microbiology*; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009414:Nerve Growth Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats; D013141:Spiro Compounds
C540632:14-norpseurotin; C540634:9-deacetoxyfumigaclavine C; C540633:9-deacetylfumigaclavine C; D000970:Antineoplastic Agents; D026121:Indole Alkaloids; D009414:Nerve Growth Factors; D013141:Spiro Compounds