Thyroid-associated autoimmune coagulation disorders.
Abnormalities of blood coagulation are not rarely observed in patients with thyroid dysfunctions and may range from subclinical laboratory abnormalities to clinically significant hemorrhagic or thrombotic complications. In this review, we summarize the current knowledge on thyroid-associated autoimmune coagulation disorders (i.e., autoimmune thrombocytopenic purpura, antiphospholipid syndrome, and autoantibodies against coagulation factor VIII) and discuss their laboratory characteristics, clinical impact, and recent progresses in the understanding of pathogenesis. Finally, we conclude that the prompt recognition of possible concomitant autoimmune coagulation disorders is important for the correct management of these patients.
Franchini
Massimo
M
Servizio di Immunoematologia e Medicina Trasfusionale, Dipartimento di Patologia e Medicina di Laboratorio, Azienda Ospedaliero-Universitaria di Parma, Parma, Italy. massimo.franchini@azosp.vr.it
Lippi
Giuseppe
G
Manzato
Franco
F
Vescovi
Pier Paolo
PP
D016736:Antiphospholipid Syndrome / Q000209:etiology*; D001323:Autoantibodies / Q000097:blood; D005169:Factor VIII / Q000276:immunology; D006801:Humans; D011696:Purpura, Thrombocytopenic / Q000209:etiology*; D013967:Thyroiditis, Autoimmune / Q000150:complications*
D001323:Autoantibodies; D005169:Factor VIII