A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype.
N-acetyltransferase-2 (NAT2) is an important enzyme that catalyzes the acetylation of aromatic and heterocyclic amine carcinogens. Individuals in human populations are divided into three NAT2 acetylator phenotypes: slow, rapid and intermediate. NAT2PRED is a web server that implements a supervised pattern recognition method to infer NAT2 phenotype from SNPs found in NAT2 gene positions 282, 341, 481, 590, 803 and 857. The web server can be used for a fast determination of NAT2 phenotypes in genetic screens.


BACKGROUND
Freely available at http://nat2pred.rit.albany.edu.


BACKGROUND
Supplementary data are available at Bioinformatics online.
Kuznetsov
Igor B
IB
Gen*NY*Sis Center for Excellence in Cancer Genomics, Department of Epidemiology and Biostatistics, University at Albany, One Discovery Drive, Rensselaer, NY 12144, USA. ikuznetsov@albany.edu
McDuffie
Michael
M
Moslehi
Roxana
R
D001191:Arylamine N-Acetyltransferase / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D005838:Genotype; D006801:Humans; D020407:Internet; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D012984:Software; D013379:Substrate Specificity
D001191:Arylamine N-Acetyltransferase; C478900:NAT2 protein, human