title: Asymmetric dihydroxylation of aryl olefins by sequential enantioselective epoxidation and regioselective hydrolysis with tandem biocatalysts.
abstract: Chiral aryl vicinal diols were obtained in high ee and yield by asymmetric dihydroxylation of aryl olefins with tandem biocatalysts: one contains an enantioselective styrene monooxygenase, and the other contains a regioselective epoxide hydrolase.
authors.affiliation: Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xu
authors.forename: Xin
authors.initials: X
authors.lastname: Jia
authors.forename: Sven
authors.initials: S
authors.lastname: Panke
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D055162:Biocatalysis; D004851:Epoxide Hydrolases / Q000737:chemistry*; D004925:Escherichia / Q000201:enzymology; D006900:Hydroxylation; D015394:Molecular Structure; D010105:Oxygenases / Q000737:chemistry*; D020578:Sphingomonas / Q000201:enzymology; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D010105:Oxygenases; C026721:styrene monooxygenase; D004851:Epoxide Hydrolases