Enhancing oxygen solubility using hemoglobin- and perfluorocarbon-based carriers.
The objective of this paper is to review the properties of fluids capable to enhance oxygen transport and transfer and recent developments in this field. This paper reviews and compares two different approaches, which could be used to solve the important problem of oxygen supply in some cell and tissue cultures: 1) hemoglobin-based and 2) perfluorocarbon-based (PFC) oxygen carriers. Several types of modified hemoglobin-based oxygen carriers (HBOCs) and their preparation are reviewed, as well as advances in the field of PFC oxygen carriers. Finally, we highlight the advantages and pitfalls, when reported in the literature, associated with each technique.
Centis
Valerie
V
Laboratoire de Bioingenierie et de Biophysique de , Universite de Sherbrooke, Department of Chemical Engineering, Universite de Sherbrooke, 2500, boul. de l'Universite, Sherbrooke, Quebec, Canada, J1K 2R1.
Vermette
Patrick
P
D000818:Animals; D004337:Drug Carriers; D005466:Fluorocarbons / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000097:blood*; D012995:Solubility
D004337:Drug Carriers; D005466:Fluorocarbons; D006454:Hemoglobins; D010100:Oxygen