title: Design, synthesis, and anti-HCV activity of thiourea compounds.
abstract: A series of thiourea derivatives were synthesized and their antiviral activity was evaluated in a cell-based HCV subgenomic replicon assay. SAR studies revealed that the chain length and the position of the alkyl linker largely influenced the in vitro anti-HCV activity of this class of potent antiviral agents. Among this series of compounds synthesized, the thiourea derivative with a six-carbon alkyl linker at the meta-position of the central phenyl ring (10) was identified as the most potent anti-HCV inhibitor (EC(50) = 0.047 microM) with a selectivity index of 596.
authors.affiliation: Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, No. 35, Keyan Road, Zhunan Town, Miaoli County 350, Taiwan, ROC.
authors.forename: Iou-Jiun
authors.initials: IJ
authors.lastname: Kang
authors.forename: Li-Wen
authors.initials: LW
authors.lastname: Wang
authors.forename: Chung-Chi
authors.initials: CC
authors.lastname: Lee
authors.forename: Yen-Chun
authors.initials: YC
authors.lastname: Lee
authors.forename: Yu-Sheng
authors.initials: YS
authors.lastname: Chao
authors.forename: Tsu-An
authors.initials: TA
authors.lastname: Hsu
authors.forename: Jyh-Haur
authors.initials: JH
authors.lastname: Chern
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D015195:Drug Design; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D012093:Replicon / Q000235:genetics; D013329:Structure-Activity Relationship; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; D013890:Thiourea