Dependence of pharmacokinetics and biodistribution on polymer architecture: effect of cyclic versus linear polymers.
The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight.
Nasongkla
Norased
N
Department of Biopharmaceutical Sciences, School of Pharmacy, University of California, 513 Parnassus Avenue, San Francisco, California 94143-0912, USA.
Chen
Bo
B
Macaraeg
Nichole
N
Fox
Megan E
ME
Fréchet
Jean M J
JM
Szoka
Francis C
FC
D000818:Animals; D001672:Biocompatible Materials; D006207:Half-Life; D051379:Mice; D008968:Molecular Conformation; D008970:Molecular Weight; D010599:Pharmacokinetics; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D001672:Biocompatible Materials; D011108:Polymers