Coronary hemodynamics in heart failure and effects of therapeutic interventions.
BACKGROUND
The abnormalities in coronary hemodynamics in systolic heart failure are frequent. Myocardial oxygen demand and consumption are increased and myocardial perfusion is also impaired, which may result in myocardial ischemia, necrosis, and apoptosis. This is potentially a contributing factor for progressive heart failure.


RESULTS
Neurohormonal abnormalities such as activated renin-angiotensin-aldosterone system, increased adrenergic activity, hemodynamic abnormalities such as decreased left ventricular perfusion pressure, and increased left ventricular diastolic pressure are important mechanisms for myocardial ischemia.


CONCLUSIONS
Different pharmacologic agents may exert different effects on coronary hemodynamics although changes in systemic hemodynamics may be similar. Some agents may enhance myocardial ischemia and others may decrease it. Thus, an understanding of changes in coronary hemodynamics may have therapeutic implications.
Chatterjee
Kanu
K
Division of Cardiology, Moffitt-Long Hospital, University of California, San Francisco, CA 94143-0124, USA. chatterj@medicine.ucsf.edu
D017209:Apoptosis; D002316:Cardiotonic Agents / Q000627:therapeutic use; D003326:Coronary Circulation / Q000187:drug effects*; D018450:Disease Progression; D054143:Heart Failure, Systolic / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism; D010101:Oxygen Consumption; D016896:Treatment Outcome
D002316:Cardiotonic Agents; D018377:Neurotransmitter Agents