Stem cell-like plasticity of naïve and distinct memory CD8+ T cell subsets.
Most models regarding the 'clonal' origin of CD8(+) T cell effector and memory subset diversification suggest that during the first contact of a naïve T cell with the priming antigen-presenting cell major decisions for subsequent differentiation are made. Data using novel single-cell T cell tracking technologies demonstrate that a single naïve CD8(+) T cell can give rise to virtually all different subtypes of effector and memory T cells, and direct major determinants of subset diversification to the time period beyond the first cell division. Thereby, some 'stem cell-like' characteristics typical for naïve T cells are probably still maintained within distinct subsets of memory T cells. These observations have direct consequences for clinical applications like adoptive T cell therapy.
Stemberger
Christian
C
Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich, Munich, Germany.
Neuenhahn
Michael
M
Gebhardt
Friedemann E
FE
Schiemann
Matthias
M
Buchholz
Veit R
VR
Busch
Dirk H
DH
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D002454:Cell Differentiation / Q000276:immunology*; D019070:Cell Lineage; D049109:Cell Proliferation; D003602:Cytotoxicity, Immunologic; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D016219:Immunotherapy, Adoptive; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction; D013234:Stem Cells / Q000276:immunology / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism*
D015415:Biomarkers; D011948:Receptors, Antigen, T-Cell