Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.
Bromophycolides J-Q (1-8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene-benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9-18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.
Lane
Amy L
AL
School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
Stout
E Paige
EP
Lin
An-Shen
AS
Prudhomme
Jacques
J
Le Roch
Karine
K
Fairchild
Craig R
CR
Franzblau
Scott G
SG
Hay
Mark E
ME
Aalbersberg
William
W
Kubanek
Julia
J
D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D000461:Rhodophyta / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000962:Antimalarials; D004224:Diterpenes