title: Clivus metastases: report of seven patients and literature review.
abstract: BACKGROUND
  Tumours of the clivus are rare and metastases involving this area have been previously described only as single case reports or included in series with other skull base tumours. Here, we describe seven such examples and review the pertinent literature.
  
  
  METHODS
  Clinical, radiological and follow-up data of patients who had undergone surgery for clivus tumours at our Institution between January 1995 and December 2007 were retrospectively collected. A literature review was performed using PubMed.
  
  
  RESULTS
  Of 46 patients who underwent surgery for clivus bone tumours, seven proved to harbour a metastasis. This figure represents 0.18% and 0.42% respectively of intracranial and skull base tumours which were treated in our Institution in the study period. The primary tumours associated were lung adenocarcinoma (n = 2), prostate carcinoma (n = 2), skin melanoma (n = 1), hepatocarcinoma (n = 1) and lung squamous cell carcinoma (n = 1). All patients presented with a sixth nerve palsy as the symptom. Histopathology was obtained via a trans-sphenoidal biopsy. In spite of radiotherapy and chemotherapy, the mean survival was 12 months. On literature review, 27 examples of metastases located in the clival bone were found. Including our series, the most common primary tumours were prostate cancer (26.4%), thyroid carcinoma (11.7%) and hepatocarcinoma (11.7%).
  
  
  CONCLUSIONS
  Though exceedingly rare, metastases involving the clivus should be considered in the differential diagnosis with clivus chordoma. The metastatic lesion might be a late and single expression of the primary tumour. The trans-sphenoidal approach is the ideal procedure to establish a histopathological diagnosis. Prognosis is poor.
authors.affiliation: Institute of Neurosurgery, Catholic University School of Medicine, Roma, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Pallini
authors.forename: Giovanni
authors.initials: G
authors.lastname: Sabatino
authors.forename: Francesco
authors.initials: F
authors.lastname: Doglietto
authors.forename: Liverana
authors.initials: L
authors.lastname: Lauretti
authors.forename: Eduardo
authors.initials: E
authors.lastname: Fernandez
authors.forename: Giulio
authors.initials: G
authors.lastname: Maira
mesh_terms: D020434:Abducens Nerve Diseases / Q000209:etiology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000556:secondary*; D003388:Cranial Fossa, Posterior / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D019292:Skull Base Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D015996:Survival Rate; D014057:Tomography, X-Ray Computed