Paraoxonase activity and dementia.
Paraoxonase activity, homocysteine level and lipids were determined in 120 patients with dementia (51 with Alzheimer disease, 28 with dementia of vascular origin, 41 with mixed dementia), 45 with mild cognitive impairment and in 61 age and sex matched controls without dementia. Paraoxonase activity was decreased in Alzheimer disease and in mixed dementia as compared with control group. In the same forms of dementia homocysteine levels were increased. In Alzheimer disease paraoxonase activity was negatively correlated with homocysteine levels. Minimental State Examination results showed positive correlation with paraoxonase activity. The results suggest an important role of oxidative stress in the development of the forms of dementia with prevailing neurodegeneration.
Wehr
Hanna
H
Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland. wehr@ipin.edu.pl
Bednarska-Makaruk
Małgorzata
M
Graban
Ałła
A
Lipczyńska-Łojkowska
Wanda
W
Rodo
Maria
M
Bochyńska
Anna
A
Ryglewicz
Danuta
D
D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000201:enzymology / Q000235:genetics; D043303:Aryldialkylphosphatase / Q000097:blood* / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003072:Cognition Disorders / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D003704:Dementia / Q000097:blood / Q000201:enzymology* / Q000235:genetics; D015140:Dementia, Vascular / Q000097:blood / Q000201:enzymology / Q000235:genetics; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA; D013053:Spectrophotometry; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D014280:Triglycerides; D006710:Homocysteine; D002784:Cholesterol; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human