Violacein extracted from Chromobacterium violaceum inhibits Plasmodium growth in vitro and in vivo.
Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum. It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi-infected mice from a lethal challenge.
Lopes
Stefanie C P
SC
Departamento de Microbiologia e Imunologia, Instituto de Biologia, Universidade Estadual de Campinas, UNICAMP, P.O. Box 6109, 13083-970 Campinas, SP, Brazil.
Blanco
Yara C
YC
Justo
Giselle Z
GZ
Nogueira
Paulo A
PA
Rodrigues
Francisco L S
FL
Goelnitz
Uta
U
Wunderlich
Gerhard
G
Facchini
Gustavo
G
Brocchi
Marcelo
M
Duran
Nelson
N
Costa
Fabio T M
FT
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D002738:Chloroquine / Q000494:pharmacology; D002861:Chromobacterium / Q000378:metabolism*; D004351:Drug Resistance; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D008288:Malaria / Q000188:drug therapy / Q000469:parasitology; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D051379:Mice; D008810:Mice, Inbred C57BL; D018512:Parasitemia / Q000188:drug therapy / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D016788:Plasmodium chabaudi / Q000187:drug effects*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D016896:Treatment Outcome
D000962:Antimalarials; D007211:Indoles; D002738:Chloroquine; C063155:violacein