title: Eliminating spiral waves pinned to an anatomical obstacle in cardiac myocytes by high-frequency stimuli.
abstract: The unpinning of spiral waves by the application of high-frequency wave trains was studied in cultured cardiac myocytes. Successful unpinning was observed when the frequency of the paced waves exceeded a critical level. The unpinning process was analyzed by a numerical simulation with a model of cardiac tissue. The mechanism of unpinning by high-frequency stimuli is discussed in terms of local entrainment failure, through a reduction of the two-dimensional spatial characteristics into one dimension.
authors.affiliation: Department of Physics, Graduate School of Science, Kyoto University and Spatio-Temporal Project, ICORP JST, Kyoto 606-8502, Japan.
authors.forename: Akihiro
authors.initials: A
authors.lastname: Isomura
authors.forename: Marcel
authors.initials: M
authors.lastname: Hörning
authors.forename: Konstantin
authors.initials: K
authors.lastname: Agladze
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yoshikawa