Communication breakdown: protein dynamics and drug design.
Mauldin et al. (2009) use NMR to show that drug binding can break up collective protein motions necessary for function. We discuss their findings in the context of drug discovery in pharmaceutical research.
Peng
Jeffrey W
JW
D001665:Binding Sites; D015195:Drug Design; D005493:Folic Acid Antagonists / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013329:Structure-Activity Relationship; D013762:Tetrahydrofolate Dehydrogenase / Q000737:chemistry* / Q000378:metabolism
D005493:Folic Acid Antagonists; D013762:Tetrahydrofolate Dehydrogenase