title: Ultrasound triggered image-guided drug delivery.
abstract: The integration of therapeutic interventions with diagnostic imaging has been recognized as one of the next technological developments that will have a major impact on medical treatments. Important advances in this field are based on a combination of progress in guiding and monitoring ultrasound energy, novel drug classes becoming available, the development of smart delivery vehicles, and more in depth understanding of the mechanisms of the cellular and molecular basis of diseases. Recent research demonstrates that both pressure sensitive and temperature sensitive delivery systems hold promise for local treatment. The use of ultrasound for the delivery of drugs has been demonstrated in particular the field of cardiology and oncology for a variety of therapeutics ranging from small drug molecules to biologics and nucleic acids.
authors.affiliation: Philips Research Europe, Biomolecular Engineering, HTC11, Eindhoven, The Netherlands. marcel.bohmer@philips.com
authors.forename: Marcel R
authors.initials: MR
authors.lastname: Böhmer
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Klibanov
authors.forename: Klaus
authors.initials: K
authors.lastname: Tiemann
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Hall
authors.forename: Holger
authors.initials: H
authors.lastname: Gruell
authors.forename: Oliver C
authors.initials: OC
authors.lastname: Steinbach
mesh_terms: D004337:Drug Carriers / Q000737:chemistry* / Q000528:radiation effects; D016503:Drug Delivery Systems / Q000379:methods*; D004867:Equipment Design; D013010:Sonication / Q000295:instrumentation* / Q000379:methods* / Q000639:trends; D014463:Ultrasonography / Q000295:instrumentation* / Q000379:methods* / Q000639:trends
chemical_list: D004337:Drug Carriers