The (mis) use of bone resorption markers in the context of bisphosphonate exposure, dental surgery and osteonecrosis of the jaw.
OBJECTIVE
To evaluate the argument for use of bone resorption markers in patients exposed to bisphosphonates and requiring dental surgery to prevent development of osteonecrosis of the jaw.


METHODS
Review of literature.


RESULTS
5 primary reports and a number of reviews were considered.


CONCLUSIONS
There is insufficient evidence to recommend use of bone resorption markers in patients exposed to bisphosphonates prior to dental surgery as a routine test to assess risk of osteonecrosis of the jaw.
Don-Wauchope
Andrew C
AC
Department of Pathology and Molecular Medicine, McMaster University and Hamilton Regional Laboratory Medicine Program, Canada. donwauc@mcmaster.ca
Cole
David E C
DE
D015415:Biomarkers / Q000378:metabolism; D001862:Bone Resorption / Q000378:metabolism*; D004164:Diphosphonates / Q000627:therapeutic use*; D006801:Humans; D007571:Jaw Diseases / Q000473:pathology*; D019647:Oral Surgical Procedures; D010020:Osteonecrosis / Q000473:pathology*
D015415:Biomarkers; D004164:Diphosphonates