title: Can we be optimistic about asthma in childhood? A Greek cohort study.
abstract: OBJECTIVE
  To examine the prevalence and natural course of asthma from childhood to adolescence in a population-based, Greek birth cohort and to identify associated factors.
  
  
  METHODS
  Longitudinal information on asthma symptoms, physician diagnosed and treated, was available for 2133 children at 7 and 18 years of age.
  
  
  RESULTS
  The prevalence of current asthma was 9.0% and 5.0% at 7 and 18 years, respectively. The prevalence of lifetime asthma was 26.3% at 18 years. More than half of the children (58.2%) with early onset asthma were asymptomatic at 7 years and only 7.6% continued to have symptoms during adolescence. However, in 48.2% of those with late onset asthma, symptoms persisted up to 18 years. Logistic regression analyses showed that male gender, family history of atopy, active adolescent smoking and maternal smoking were significantly positively associated with lifetime asthma at 18 years. In addition, smoking during pregnancy was associated with an increased risk for persistence of asthma symptoms at 18 years. Asthma during childhood and active adolescent smoking were positively associated, and daily consumption of fruit and vegetables was negatively associated with current asthma at 18 years of age. Finally, children who were breastfed had a lower risk for lifetime asthma at 7 years.
  
  
  CONCLUSIONS
  The prevalence of asthma symptoms at 7 and 18 years of age was low throughout Greece. Our results suggest that, among others, nutrition is an important correlate of asthma in Greek children.
authors.affiliation: 1st Department of Paediatrics, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
authors.forename: Flora
authors.initials: F
authors.lastname: Bacopoulou
authors.forename: Alexandra
authors.initials: A
authors.lastname: Veltsista
authors.forename: Ippolyti
authors.initials: I
authors.lastname: Vassi
authors.forename: Artemis
authors.initials: A
authors.lastname: Gika
authors.forename: Vasso
authors.initials: V
authors.lastname: Lekea
authors.forename: Kostas
authors.initials: K
authors.lastname: Priftis
authors.forename: Chryssa
authors.initials: C
authors.lastname: Bakoula
mesh_terms: D000293:Adolescent; D017668:Age of Onset; D001249:Asthma / Q000453:epidemiology*; D001942:Breast Feeding / Q000706:statistics & numerical data; D002648:Child; D003876:Dermatitis, Atopic / Q000453:epidemiology; D004032:Diet / Q000706:statistics & numerical data; D005260:Female; D005638:Fruit; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology; D015995:Prevalence; D006255:Rhinitis, Allergic, Seasonal / Q000453:epidemiology; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014675:Vegetables