A preliminary neutron crystallographic study of an A-DNA crystal.
The LADI-III diffractometer at the Institut Laue-Langevin has been used to carry out a preliminary neutron crystallographic study of the self-complementary DNA oligonucleotide d(AGGGGCCCCT)(2) in the A conformation. The results demonstrate the viability of a full neutron crystallographic analysis with the aim of providing enhanced information on the ion-water networks that are known to be important in stabilizing A-DNA. This is the first account of a single-crystal neutron diffraction study of A-DNA. The study was carried out with the smallest crystal used to date for a neutron crystallographic study of a biological macromolecule.
Leal
Ricardo M F
RM
ESRF, Grenoble, France.
Teixeira
Susana C M
SC
Blakeley
Matthew P
MP
Mitchell
Edward P
EP
Forsyth
V Trevor
VT
D003460:Crystallization; D044704:DNA, A-Form / Q000737:chemistry*; D006859:Hydrogen; D033363:Neutron Diffraction; D009841:Oligonucleotides / Q000737:chemistry
D044704:DNA, A-Form; D009841:Oligonucleotides; D006859:Hydrogen