Adult hippocampal neurogenesis is involved in anxiety-related behaviors.
Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.
Revest
J-M
JM
INSERM U862, Neurocenter Magendie, Pathophysiology of Addiction group, Bordeaux, France.
Dupret
D
D
Koehl
M
M
Funk-Reiter
C
C
Grosjean
N
N
Piazza
P-V
PV
Abrous
D N
DN
D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002452:Cell Count; D002707:Chlordiazepoxide / Q000494:pharmacology; D003863:Depression / Q000503:physiopathology; D004318:Doxycycline / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism
D051028:bcl-2-Associated X Protein; D002707:Chlordiazepoxide; D004318:Doxycycline