Microchip atmospheric pressure photoionization for analysis of petroleum by Fourier transform ion cyclotron resonance mass spectrometry.
Atmospheric pressure photoionization (APPI) Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) has significantly contributed to the molecular speciation of petroleum. However, a typical APPI source operates at 50 microL/min flow rate and thus causes a considerable mass load to the mass spectrometer. The recently introduced microchip APPI (microAPPI) operates at much lower flow rates (0.05-10 microL/min) providing decreased mass load and therefore decreased contamination in analysis of petroleum by FT-ICR MS. In spite of the 25 times lower flow rate, the signal response with microAPPI was only 40% lower than with a conventional APPI source. It was also shown that microAPPI provides very efficient vaporization of higher molecular weight components in petroleum analysis.
Haapala
Markus
M
Division of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 Helsinki, Finland.
Purcell
Jeremiah M
JM
Saarela
Ville
V
Franssila
Sami
S
Rodgers
Ryan P
RP
Hendrickson
Christopher L
CL
Kotiaho
Tapio
T
Marshall
Alan G
AG
Kostiainen
Risto
R
D001274:Atmospheric Pressure; D005240:Feasibility Studies; D005583:Fourier Analysis; D013058:Mass Spectrometry / Q000379:methods*; D046208:Microchip Analytical Procedures / Q000379:methods*; D010578:Petroleum / Q000032:analysis*; D055668:Photochemical Processes
D010578:Petroleum