Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
Siezen
Christine L E
CL
Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
Bont
Louis
L
Hodemaekers
Hennie M
HM
Ermers
Marieke J
MJ
Doornbos
Gerda
G
Van't Slot
Ruben
R
Wijmenga
Ciska
C
Houwelingen
Hans C van
HC
Kimpen
Jan L L
JL
Kimman
Tjeerd G
TG
Hoebee
Barbara
B
Janssen
Riny
R
D051722:ADAM Proteins / Q000235:genetics; D001990:Bronchiolitis, Viral / Q000235:genetics*; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000235:genetics*; D008168:Lung / Q000254:growth & development; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics; D018357:Respiratory Syncytial Virus Infections / Q000235:genetics*; D012307:Risk Factors
D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human; D051722:ADAM Proteins; C450441:ADAM33 protein, human