title: CCR5 proinflammatory allele in prostate cancer risk: a pilot study in patients and centenarians from Sicily .
abstract: Prostate cancer (PCa) is the most common malignant neoplasm in older men in Western countries. The number of affected older men is increasing. Therefore, strategies for prevention of prostate cancer are crucial. To this purpose it is essential to know the mechanisms involved in development and progression of this malignancy. Recently, an increasing body of genetic and epidemiological studies proposed new hypotheses for prostate carcinogenesis. It has been suggested that genetic factors as well as exposure to environmental factors such as infectious agents, dietary carcinogens, and hormonal imbalances participate in PCa development. Besides, chronic inflammation plays a key role in PCa. Taking into consideration this complex scenario, in the present study we evaluated whether CCR5Delta32 deletion of CCR5 gene might be associated with PCa susceptibility. For the control group we used centenarians, since they represent a disease-free human model. These preliminary results suggest that the CCR5Delta32 anti-inflammatory variant might be a resistance factor for the development of PCa.
authors.affiliation: Gruppo di Studio sull'Immunosenescenza, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy. crbalistreri@unipa.it
authors.forename: Carmela Rita
authors.initials: CR
authors.lastname: Balistreri
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Carruba
authors.forename: Maurizio
authors.initials: M
authors.lastname: Calabrò
authors.forename: Ildegarda
authors.initials: I
authors.lastname: Campisi
authors.forename: Daniele
authors.initials: D
authors.lastname: Di Carlo
authors.forename: Domenico
authors.initials: D
authors.lastname: Lio
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Colonna-Romano
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Candore
authors.forename: Calogero
authors.initials: C
authors.lastname: Caruso
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D008297:Male; D010865:Pilot Projects; D011471:Prostatic Neoplasms / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*
chemical_list: D018836:Inflammation Mediators; D019713:Receptors, CCR5