Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes.
OBJECTIVE
To examined whether serum paraoxonase (PON1) and arylesterase (ARE) activities are correlated with inflammatory biomarkers (procalcitonin and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS).


METHODS
This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turkey, from April 2007 to December 2007. Seventy-eight consecutive patients with ACS and 39 healthy controls were investigated. Acute coronary syndrome patients were divided into 3 groups according to their clinical presentation: unstable angina pectoris (UAP) (Braunwald III-B, n=25), non-ST elevation myocardial infarction (NSTEMI) (n=18), and ST-elevation myocardial infarction (STEMI) (n=35). Serum PON1/ARE activities were measured spectrophotometrically. Levels of procalcitonin and hs-CRP were measured by immunoassay.


RESULTS
Paraoxonase/ARE activities were significantly lower in all patient groups compared to controls. No correlation between PON1/ARE activities and high-density-cholesterol levels was seen. Among ACS patients, serum ARE activity correlated inversely with baseline and 48-hour procalcitonin (r=-0.577, p=0.009, and r=-0.642, p=0.019) and hs-CRP levels (r=-0.614, p=0.03, and r=-0.719, p=0.044).


CONCLUSIONS
Serum ARE activity is reduced in ACS patients and inversely correlated with inflammatory markers.
Senturk
Tunay
T
Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. tunaysenturk@hotmail.com
Sarandol
Emre
E
Gullulu
Sumeyye
S
Erdinc
Selda
S
Ozdabakoglu
Osman
O
Ozdemir
Bulent
B
Baran
Ibrahim
I
Arslan
Sinan
S
Aydinlar
Ali
A
D054058:Acute Coronary Syndrome / Q000201:enzymology*; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood; D018709:Statistics, Nonparametric
D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; D015740:Calcitonin Gene-Related Peptide