Relationship between adiponectin, inflammatory markers and obesity in type 2 diabetic and non-diabetic Trinidadians.
OBJECTIVE
To determine and study the relationship between adiponectin and inflammatory markers in obese, non-obese, type 2 diabetic and non-diabetic Trinidadians.


METHODS
It was a cross-sectional study comprised of 133 subjects of Trinidadians. Anthropometric indices were measured and adiponectin, inflammatory marker levels, lipid profiles and glucose were measured in fasting blood samples.


RESULTS
Adiponectin levels were significantly lower (P = 0.003) in diabetics (n = 60) than non diabetics (n = 73). No correlation between adiponectin and inflammatory markers was found. Adiponectin levels were negatively correlated with BMI adjusting for age and diabetic status, and gender (beta = -0.200, P = 0.020; beta = -0.235, P = 0.004).


CONCLUSIONS
No correlation exists between adiponectin and inflammatory markers. Adiponectin levels are lower in type 2 diabetic Trinidadians than in non-diabetics and decreases with increasing adiposity, using BMI as the marker.
Nayak
Shivananda
S
University of the West Indies, Champs Fleurs, Trinidad and Tobago. shiv25@gmail.com
Soon
Stephanie Quan
SQ
Kunjal
Ryan
R
Ramadoo
Ria
R
Baptiste
Okera
O
Persad
Josann
J
Temull
Vasant
V
Diptee
Leon
L
Balgobin
Sophia
S
D052242:Adiponectin / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood*; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D014300:Trinidad and Tobago; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
D052242:Adiponectin; D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein