title: Evaluation of plexiform neurofibroma in neurofibromatosis type 1 in 18 family members of 3 generations: ultrasonography and magnetic resonance imaging a diagnostic supplement.
abstract: Abstract Plexiform neurofibroma in neurofibromatosis type 1, an autosomal-dominant genetic disorder, is characterized by a combination of interlacing components or a network. The prominent enlargement of a nerve with tumor nodules results in the gross pathologic appearance termed "bag of worms." Plexiform neurofibroma was found in two of seven family members with neurofibromatosis type 1 in three generations. Ultrasonography/color doppler and magnetic resonance imaging, in addition to microscopic pathology, were used as diagnostic tools, and their indications for future use in the diagnosis of plexiform neurofibroma are highlighted.
authors.affiliation: Dermato-Venereology (Skin/VD) Centre, Sehgal Nursing Home, Panchwati, Delhi, India. drsehgal@ndf.vsnl.net.in
authors.forename: Virendra N
authors.initials: VN
authors.lastname: Sehgal
authors.forename: Sonal
authors.initials: S
authors.lastname: Sharma
authors.forename: Rakesh
authors.initials: R
authors.lastname: Oberai
mesh_terms: D000328:Adult; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018318:Neurofibroma, Plexiform / Q000175:diagnosis* / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D018615:Ultrasonography, Doppler, Color