Design, synthesis and anti-HIV integrase evaluation of 4-oxo-4H-quinolizine-3-carboxylic acid derivatives.
4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
Xu
Yi-Sheng
YS
Beijing University of Technology, P. R. China. xuys@craes.org.cn
Zeng
Cheng-Chu
CC
Jiao
Zi-Guo
ZG
Hu
Li-Ming
LM
Zhong
Ru-gang
RG
D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
D002264:Carboxylic Acids; D019428:HIV Integrase Inhibitors; D011807:Quinolizines; D019427:HIV Integrase; D008274:Magnesium