Preservation of basophils in dapsone-induced agranulocytosis suggests a possible pathogenetic role for leucocyte peroxidases.
We describe a hitherto unreported laboratory observation, namely the selective preservation of basophils, in a case of severe dapsone-induced agranulocytosis. Dapsone is known to be metabolised by peroxidases to nitroso derivatives in non-hemopoietic cells where these can in turn act as haptens. Our observation that basophils are selectively spared in this syndrome supports the hypothesis that leucocyte peroxidases function in a similar way to facilitate the pathogenesis of this form of agranulocytosis in susceptible individuals.
Besser
M
M
Department of Haematology, West Suffolk Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK.
Vera
J
J
Clark
J
J
Chitnavis
D
D
Beatty
C
C
Vassiliou
G
G
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000201:enzymology*; D001491:Basophils / Q000201:enzymology; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy*; D010544:Peroxidases / Q000378:metabolism*; D014021:Tissue Preservation
D003622:Dapsone; D010544:Peroxidases