title: A nonlinear model of the neural integrator improves detection of deficits in the human VOR.
abstract: A nonlinear model has been proposed to describe the set-point-dependent characteristics of the neural integrator (NI) in the oculomotor system. It was shown to yield improved prediction of slow-phase eye position in the vestibulo-ocular reflex (VOR) of normal subjects, when compared to the classical linear model of the NI. In this paper, we compare the parameters of this nonlinear NI model fitted to VOR data from: 1) compensated subjects diagnosed with vestibular deficiencies such as vestibular neuronitis and Meniere's disease and 2) normal (symptom-free) subjects. The identified models exhibit more severe nonlinearity in VOR patients than the normal controls. Several of the identified parameters in patients unmask asymmetries and more context dependence in the NI and in the VOR gain that are consistent with the lesioned side and could serve to support detection of lesions even after compensation.
authors.affiliation: Department of Biomedical Engineering, McGill University, Montreal, QC, Canada. wilbur.chan@mcgill.ca
authors.forename: Wilbur
authors.initials: W
authors.lastname: Chan
authors.forename: Henrietta L
authors.initials: HL
authors.lastname: Galiana
mesh_terms: D003198:Computer Simulation; D005133:Eye Movements; D006801:Humans; D008959:Models, Neurological; D017711:Nonlinear Dynamics; D012027:Reflex, Vestibulo-Ocular; D012665:Semicircular Canals / Q000503:physiopathology*; D015837:Vestibular Diseases / Q000503:physiopathology*; D014726:Vestibular Nuclei / Q000503:physiopathology*