title: Scraping cytology with a guidewire for pancreatic-ductal strictures.
abstract: BACKGROUND
  Strictures of the pancreatic duct may be caused by a variety of underlying pathologic conditions that imaging examinations often fail to define. Conventional procedures for acquisition of a specimen for cytology during ERCP have been limited in their ability to discriminate pancreatic-ductal strictures.
  
  
  OBJECTIVE
  Our aim was to discriminate pancreatic-ductal strictures by a new technique of sampling material for cytodiagnosis: scraping cytology with a guidewire.
  
  
  METHODS
  A retrospective study.
  
  
  METHODS
  A single cancer center.
  
  
  METHODS
  Eighty-six patients with pancreatic-ductal strictures composed of 71 malignant and 15 benign diseases were evaluated. Malignant diseases included 70 pancreatic carcinomas and 1 endocrine tumor; benign diseases included the following: 7 chronic pancreatitis, 3 autoimmune pancreatitis, 3 idiopathic pancreatic-ductal strictures, and 2 pancreatic cysts. During ERCP, pancreatic juice was collected with a cannula in the main duct just below the stricture after scraping it with a 0.025-inch hydrophilic guidewire. Cytodiagnosis of the specimen was performed by the Papanicolaou method.
  
  
  METHODS
  Diagnostic sensitivities and specificities of scraping cytology with a guidewire for pancreatic carcinoma.
  
  
  RESULTS
  Scraping cytology with a guidewire yielded 93% sensitivity, 100% specificity, 100% positive predictive value, 75% negative predictive value, and 94% accuracy. Sensitivities for pancreatic carcinoma in the head, body, and tail of the pancreas were 91%, 100%, and 91%, respectively. Sensitivities for pancreatic carcinoma with a tumor of <20 mm, 21 to 40 mm, 41 to 60 mm, and >61 mm were 95%, 92%, 100%, and 100%, respectively. Pancreatitis subsequent to the procedure occurred in 4 patients (5%), all of whom were cured by conservative treatment.
  
  
  CONCLUSIONS
  Benign or malignant pancreatic-ductal strictures were accurately discriminated by scraping cytology with a guidewire during ERCP. The technique yielded high diagnostic sensitivities in pancreatic carcinoma, regardless of the location or size of the tumor.
authors.affiliation: Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan. uehara-hi@mc.pref.osaka.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uehara
authors.forename: Koichi
authors.initials: K
authors.lastname: Tatsumi
authors.forename: Eriko
authors.initials: E
authors.lastname: Masuda
authors.forename: Motohiko
authors.initials: M
authors.lastname: Kato
authors.forename: Takashi
authors.initials: T
authors.lastname: Kizu
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Ishida
authors.forename: Rena
authors.initials: R
authors.lastname: Takakura
authors.forename: Yasuna
authors.initials: Y
authors.lastname: Takano
authors.forename: Akihiko
authors.initials: A
authors.lastname: Nakaizumi
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishikawa
authors.forename: Akemi
authors.initials: A
authors.lastname: Takenaka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods; D002760:Cholangiopancreatography, Endoscopic Retrograde; D003251:Constriction, Pathologic; D003584:Cytological Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010183:Pancreatic Ducts / Q000473:pathology*; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity