title: [Pathogenesis of portal systemic encephalopathy].
abstract: Hepatic encephalopathy is a neuropsyquiatric syndrome associated to multifactorial metabolic disruptions. Several physiopathogenic theories have been proposed. In this review authors explain and analyze most of theses theories which include ammonia, mercaptans, false neurotransmitters, gamma aminobutiric acid, endogenous benzodiazepins, and zinc deficiency as well as some of the new biochemical concepts of neurotransmission.
authors.affiliation: Departamento de Medicina Interna, Servicio de Gastroenterología del Hospital Universitario "Dr. José E. González" de la Universidad Autónoma de Nuevo León, Monterrey, NL México.
authors.forename: D
authors.initials: D
authors.lastname: García Compeán
authors.forename: R
authors.initials: R
authors.lastname: Valadez Castillo
authors.forename: R F
authors.initials: RF
authors.lastname: Barragán
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism; D006501:Hepatic Encephalopathy / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D018377:Neurotransmitter Agents / Q000378:metabolism; D011963:Receptors, GABA-A / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism; D015032:Zinc / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D000596:Amino Acids; D005227:Fatty Acids; D008024:Ligands; D018377:Neurotransmitter Agents; D011963:Receptors, GABA-A; D013438:Sulfhydryl Compounds; D005680:gamma-Aminobutyric Acid; D000641:Ammonia; D015032:Zinc