[Role of cellular proteins in the life cycle of human immunodeficiency virus].
The paper shows a role of cellular proteins that control the early and late stages of HIV infection due to the keen genetic parasitism of human immunodeficiency virus (HIV). In its early life cycle, the virus uses the cell receptors CD4, CCR5, G-protein processor, and actin filaments of the cytoskeleton for nuclear transport. The cellular proteins transport the preintegration complex through the nuclear pores and assist complementary DNA to integrate with cellular DNA. At late stages, the cellular proteins provide the transport of viral components to the assemblage site--lipid rafts, the strong binding to them, the insertion of glycoproteins into the viral particle, and the cellular escape of the virus. To inhibit the cellular mechanisms involved in the infectious process is a new antiviral strategy approach to treating AIDS.
Bukrinskaia
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D008841:Actin Cytoskeleton / Q000502:physiology; D015704:CD4 Antigens / Q000502:physiology; D019204:GTP-Binding Proteins / Q000502:physiology; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000378:metabolism* / Q000821:virology*; D006801:Humans; D021962:Membrane Microdomains / Q000502:physiology; D019713:Receptors, CCR5 / Q000502:physiology; D016662:Virus Integration / Q000502:physiology; D014779:Virus Replication / Q000502:physiology*
D015704:CD4 Antigens; D019713:Receptors, CCR5; D019204:GTP-Binding Proteins