title: Low-dose aspirin therapy to prevent ovarian hyperstimulation syndrome.
abstract: OBJECTIVE
  To evaluate the effect of low-dose aspirin therapy on ovarian hyperstimulation syndrome (OHSS) in an unselected group of patients undergoing in vitro fertilization (IVF).
  
  
  METHODS
  Randomized clinical trial.
  
  
  METHODS
  Division of Reproductive Medicine at the Department of Obstetrics and Gynecology, University of Pécs, Faculty of Medicine, Pécs, Hungary.
  
  
  METHODS
  Patients who underwent IVF between 2000 and 2006.
  
  
  METHODS
  Initiation of 3154 IVF cycles, for which gonadotropin-releasing hormone agonist was used in 2425 cycles; 1503 cycles randomly selected for low-dose aspirin treatment starting from the first day of controlled ovarian hyperstimulation compared with no treatment in the remaining 922 cycles.
  
  
  METHODS
  The incidence of severe or critical OHSS and the rate of clinical pregnancy.
  
  
  RESULTS
  During this time period, 45 cases of severe OHSS were detected. Only two of the OHSS patients had received aspirin previously.
  
  
  CONCLUSIONS
  Based on our preliminary results, introduction of low-dose aspirin therapy during ovulation induction for the prevention of OHSS in high-risk patients should be considered.
authors.affiliation: Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, H-7624 Pécs, Hungary. akos.varnagy@aok.pte.hu
authors.forename: Akos
authors.initials: A
authors.lastname: Várnagy
authors.forename: József
authors.initials: J
authors.lastname: Bódis
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Mánfai
authors.forename: Ferenc
authors.initials: F
authors.lastname: Wilhelm
authors.forename: Csaba
authors.initials: C
authors.lastname: Busznyák
authors.forename: Miklós
authors.initials: M
authors.lastname: Koppán
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin