title: The CNS midline cells and Egfr signaling genes are required for establishment of the RP2 motoneuron lineage in the Drosophila central nervous system.
abstract: It is well established that CNS midline cells are essential for the identity determination, division, and differentiation of neurons and glia in the Drosophila CNS. However, it is not clear whether CNS midline cells control the establishment and differentiation of the well-known RP2 motoneuron lineage. The present study showed by using several RP2 lineage markers that CNS midline cells and Egfr signaling genes are required for identity determination and formation of precursors of the RP2 motoneurons. Overexpression and ectopic expression of sim and components of the EGFR signaling pathway in the ventral neuroectoderm induced the formation of extra RP2s and their sibling cells by activating EGFR signaling. We demonstrated that CNS midline cells and Egfr signaling genes play essential roles in the establishment of the RP2 motoneuron lineage.
authors.affiliation: Department of Chemistry, Konkuk University, 1 Hwayang-dong Gwangjin-gu, Seoul 143-701, Republic of Korea.
authors.forename: Jung Yun
authors.initials: JY
authors.lastname: Huh
authors.forename: Sang-Hak
authors.initials: SH
authors.lastname: Jeon
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Kim
mesh_terms: D000818:Animals; D002460:Cell Line; D019070:Cell Lineage / Q000235:genetics*; D002490:Central Nervous System / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism; D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology*; D009046:Motor Neurons / Q000166:cytology* / Q000378:metabolism; D018010:Receptors, Invertebrate Peptide / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; C087725:Hkb protein, Drosophila; D018010:Receptors, Invertebrate Peptide; C066532:Egfr protein, Drosophila; D066246:ErbB Receptors