title: Two cases of bovine sarcoma in clinically long-standing lesions.
abstract: Histopathological examination of clinically long-standing lesions with durations of one year or more in the extremities of two cattle revealed the presence of sarcomas with distant metastases. In case 1, neoplastic cells were fusiform to pleomorphic, stained for no specific differentiation markers, and diagnosed as undifferentiated sarcoma. Neoplastic growth in case 2 was composed of spindle to histiocytoid cells and a significant number of multinucleated giant cells, both of which were immunoreactive to histiocyte markers, and diagnosed as giant cell malignant fibrous histiocytoma. Neoplastic cells of both cases were immunohistochemically positive for nitric oxide-related antigens, which were recognized as markers of inflammation-induced carcinogenesis in human and laboratory animals.
authors.affiliation: Department of Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan. kmatsuda@rakuno.ac.jp
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsuda
authors.forename: Kanako
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Shushi
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Takafumi
authors.initials: T
authors.lastname: Higashi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Taguchi
authors.forename: Masateru
authors.initials: M
authors.lastname: Koiwa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Taniyama
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D051677:Histiocytoma, Malignant Fibrous / Q000473:pathology / Q000662:veterinary; D007150:Immunohistochemistry; D007249:Inflammation / Q000473:pathology; D009569:Nitric Oxide; D012509:Sarcoma / Q000473:pathology* / Q000662:veterinary; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000662:veterinary
chemical_list: D009569:Nitric Oxide