Highly enantioselective and diastereoselective synthesis of chiral amino alcohols by ruthenium-catalyzed asymmetric hydrogenation of alpha-amino aliphatic ketones.
A highly efficient asymmetric hydrogenation of racemic acyclic alpha-amino aliphatic ketones via dynamic kinetic resolution has been realized, providing chiral amino alcohols in excellent enantioselectivities and diastereoselectivities. A hydrogen-bonding transition state mode was proposed for explaining the high diastereoselectivity and enantioselectivity of the reaction.
Xie
Jian-Hua
JH
State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Liu
Sheng
S
Kong
Wei-Ling
WL
Bai
Wen-Ju
WJ
Wang
Xiao-Chen
XC
Wang
Li-Xin
LX
Zhou
Qi-Lin
QL