title: Validation of continuous glucose monitoring in children and adolescents with cystic fibrosis: a prospective cohort study.
abstract: OBJECTIVE
  To validate continuous glucose monitoring (CGM) in children and adolescents with cystic fibrosis.
  
  
  METHODS
  Paired oral glucose tolerance tests (OGTTs) and CGM monitoring was undertaken in 102 children and adolescents with cystic fibrosis (age 9.5-19.0 years) at baseline (CGM1) and after 12 months (CGM2). CGM validity was assessed by reliability, reproducibility, and repeatability.
  
  
  RESULTS
  CGM was reliable with a Bland-Altman agreement between CGM and OGTT of 0.81 mmol/l (95% CI for bias +/- 2.90 mmol/l) and good correlation between the two (r = 0.74-0.9; P < 0.01). CGM was reproducible with no significant differences in the coefficient of variation of the CGM assessment between visits and repeatable with a mean difference between CGM1 and CGM2 of 0.09 mmol/l (95% CI for difference +/- 0.46 mmol/l) and a discriminant ratio of 13.0 and 15.1, respectively.
  
  
  CONCLUSIONS
  In this cohort of children and adolescents with cystic fibrosis, CGM performed on two occasions over a 12-month period was reliable, reproducible, and repeatable.
authors.affiliation: National Children's Hospital, Tallaght, Dublin, Ireland. s.oriordan@ich.ucl.ac.uk
authors.forename: Stephen M P
authors.initials: SM
authors.lastname: O'Riordan
authors.forename: Peter
authors.initials: P
authors.lastname: Hindmarsh
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Hill
authors.forename: David R
authors.initials: DR
authors.lastname: Matthews
authors.forename: Sherly
authors.initials: S
authors.lastname: George
authors.forename: Peter
authors.initials: P
authors.lastname: Greally
authors.forename: Gerard
authors.initials: G
authors.lastname: Canny
authors.forename: Dubhfeasa
authors.initials: D
authors.lastname: Slattery
authors.forename: Nuala
authors.initials: N
authors.lastname: Murphy
authors.forename: Edna
authors.initials: E
authors.lastname: Roche
authors.forename: Colm
authors.initials: C
authors.lastname: Costigan
authors.forename: Hilary
authors.initials: H
authors.lastname: Hoey
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D018670:Monitoring, Ambulatory / Q000379:methods*; D008991:Monitoring, Physiologic / Q000379:methods*; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D001786:Blood Glucose