Tuberculosis complicating hepatitis C treatment in HIV-infected patients.
Tuberculosis characteristics and incidence were assessed among patients with concurrent human immunodeficiency virus infection and chronic hepatitis C virus infection who were receiving interferon-based therapy at 3 hospitals in Spain. Four of 570 patients (0.7 cases per 100 person-years; 95% confidence interval, 0.19-1.78 cases per 100 person-years) received a diagnosis of tuberculosis; all of them presented with a decrease in CD4+ cell count before diagnosis, and 3 of them received a delayed diagnosis. After tuberculosis treatment, all patients were cured.
Pérez-Elías
Maria Jesús
MJ
Department of Infectious Diseases, Ramon y Cajal Hospital, Madrid, Spain. mjperez@telefonica.net
García-San Miguel
Lucía
L
González García
Juan
J
Montes Ramírez
Maria Luisa
ML
Muriel
Alfonso
A
Machín-Lázaro
Jose M
JM
Martínez-Baltanás
Aida
A
Zamora
Francisco
F
Moreno
Ana
A
Martín-Dávila
Pilar
P
Quereda
Carmen
C
Gómez-Mampaso
Enrique
E
Moreno
Santiago
S
D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014374:Tuberculin Test; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy
D000998:Antiviral Agents; D007372:Interferons