Interaction of genistein benzyl derivatives with lipid bilayers--fluorescence spectroscopic and calorimetric study.
The purpose of the present paper was to assess the ability of genistein benzyl derivatives to interact with lipid bilayers. Calorimetric and fluorescence spectroscopic measurements revealed that, depending on the details of chemical structure, the studied compounds penetrated bilayers and affected their polar as well as hydrophobic regions. It was also found that physical state of bilayer played some role in flavonoid-lipid interactions.
Maniewska
J
J
Department of Biophysics, Wrocław Medical University, Wrocław, Poland.
Grynkiewicz
G
G
Szeja
W
W
Hendrich
A B
AB
D002151:Calorimetry / Q000379:methods*; D019833:Genistein / Q000737:chemistry*; D008051:Lipid Bilayers; D013050:Spectrometry, Fluorescence / Q000379:methods*
D008051:Lipid Bilayers; D019833:Genistein