Antioxidant activities of new flavonoids from Cudrania tricuspidata root bark.
Two new flavonoids, hydroxybenzyl flavonoid glycosides (6-p-hydroxybenzyl kaempferol-7-O-beta-D-glucopyranoside named cudranian 1 and 6-p-hydroxybenzyl quercetin-7-O-beta-D-glucopyranoside named cudranian 2), and 3 known flavonoids (kaempferol-7-O-beta-D-glucopyranoside, quercetin-7-O-beta-D-glucopyranoside and aromadendrin) were isolated from root bark of Cudrania tricuspidata and their structures were elucidated by spectroscopic methods. These compounds showed remarkable radical scavenging effects against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and anti-lipid peroxidation efficacy on human low-density lipoprotein by TBARS assay.
Lee
Young Jae
YJ
College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Kim
Sungun
S
Lee
Seung Jae
SJ
Ham
Inhye
I
Whang
Wan Kyunn
WK
D001713:Biphenyl Compounds / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry; D015394:Molecular Structure; D029586:Moraceae / Q000737:chemistry*; D010084:Oxidation-Reduction; D010851:Picrates / Q000737:chemistry; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D017392:Thiobarbituric Acid Reactive Substances / Q000737:chemistry
D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D008077:Lipoproteins, LDL; D010851:Picrates; D017392:Thiobarbituric Acid Reactive Substances; C004931:1,1-diphenyl-2-picrylhydrazyl