title: [Isolated intracranial relapse in previously treated Hodgkin's disease].
abstract: Isolated brain relapse is uncommon in Hodgkin's lymphoma and often linked with advanced or refractory disease.
  
  
  METHODS
  We report two patients with stage IV Hodgkin's disease, previously treated with chemotherapy, who later developed neurological symptoms. Brain MRI demonstrated two different types of lesions. Histological findings were consistent with intracranial location of Hodgkin lymphoma. Both of the patients presented only with isolated CNS relapse of the lymphoma.
  
  
  CONCLUSIONS
  The two cases demonstrated the MRI appearance of intracranial involvement can be varied and mimic other disease processes in patients with a previous history of Hodgkin's lymphoma. Thus, a biopsy is necessary for diagnosis and correct treatment.
authors.affiliation: Service de neurochirurgie B, hôpital Roger-Salengro, CHRU, rue Emile-Laine, 59037 Lille cedex, France. c-ramirez@chru-lille.fr
authors.forename: C
authors.initials: C
authors.lastname: Ramirez
authors.forename: N
authors.initials: N
authors.lastname: Reyns
authors.forename: M
authors.initials: M
authors.lastname: Ayachi
authors.forename: S
authors.initials: S
authors.lastname: Blond
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000473:pathology*; D005260:Female; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging