title: Altered flow-mediated vasodilatation, low paraoxonase-1 activity, and abnormal high-density lipoprotein subclass distribution in Takayasu's arteritis.
abstract: BACKGROUND
  Takayasu's arteritis (TA) is an idiopathic chronic inflammatory disease that causes occlusion of large arteries, but little is known about whether affected patients are characterized by endothelial dysfunction, different high-density lipoproteins (HDL) subclasses and paraoxonase-1 (PON1) activity.
  
  
  RESULTS
  In the present study, 30 patients with TA, 30 age- and gender-matched volunteers (controls) and 15 patients with essential hypertension were studied. Flow-mediated vasodilation (FMD) and maximal blood flow velocity, assessed in the brachial artery by high-resolution ultrasound, were significantly lower in patients. HDL subclass distribution was determined by polyacrylamide gradient gel electrophoresis. HDL-cholesterol, HDL3b subclass and PON1 activity, assessed spectrophotometrically using phenylacetate as the substrate, were also lower in patients compared with controls. In a multiple regression analysis, the use of prednisone and systolic blood pressure were independent variables that predicted the FMD.
  
  
  CONCLUSIONS
  A low FMD, abnormal size distribution of HDLs, and low PON1 activity are observed in TA patients. These abnormalities appear independently and constitute a cluster that may contribute to the vascular dysfunction of TA arteritis.
authors.affiliation: Echocardiography in Out Patient Clinic, Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
authors.forename: Nilda
authors.initials: N
authors.lastname: Espinola-Zavaleta
authors.forename: María Elena
authors.initials: ME
authors.lastname: Soto-López
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Carreón-Torres
authors.forename: Ricardo
authors.initials: R
authors.lastname: Gamboa
authors.forename: Ana M
authors.initials: AM
authors.lastname: Mejía
authors.forename: Ricardo
authors.initials: R
authors.lastname: Márquez-Velasco
authors.forename: Rafael
authors.initials: R
authors.lastname: Bojalil
authors.forename: Claudia
authors.initials: C
authors.lastname: Huesca-Gomez
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Reyes
authors.forename: Oscar
authors.initials: O
authors.lastname: Pérez-Méndez
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000097:blood*; D001783:Blood Flow Velocity; D005260:Female; D006801:Humans; D053440:Lipoproteins, HDL3 / Q000097:blood*; D008875:Middle Aged; D013625:Takayasu Arteritis / Q000097:blood* / Q000503:physiopathology; D014664:Vasodilation
chemical_list: D053440:Lipoproteins, HDL3; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human