title: [Clinical and epidemiological features of tuberculosis ostitis in BCG-vaccinated children].
abstract: There has been a drastic increase in the incidence of ostitis in children since 2001. Comparison of current tuberculous ostitis (n = 70) and primary pulmonary tuberculosis (n = 60) in infants revealed significant clinical and epidemiological differences. Molecular genetic methods identified BCG M. bovis strain DNA in 13 (46.4%) intraoperative samples and 4 samples of obtained cultures from bone destruction foci. Isolation of BCG cultures and/or verification of BCG M. ovis DNA from the bone lesion focus by polymerase chain reaction is a significant criterion for verification of the BCG etiology of ostitis having a morphological pattern of productive necrotic tuberculosis in children.
authors.forename: N G
authors.initials: NG
authors.lastname: Kamaeva
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Chugaev
authors.forename: L M
authors.initials: LM
authors.lastname: Grinberg
authors.forename: N A
authors.initials: NA
authors.lastname: Anisimova
authors.forename: T V
authors.initials: TV
authors.lastname: Golubeva
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Kamaev
mesh_terms: D001500:BCG Vaccine / Q000009:adverse effects*; D002675:Child, Preschool; D004269:DNA, Bacterial / Q000032:analysis; D006801:Humans; D015994:Incidence; D007223:Infant; D009163:Mycobacterium bovis / Q000235:genetics / Q000302:isolation & purification*; D010000:Osteitis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000382:microbiology; D016133:Polymerase Chain Reaction; D012800:Siberia / Q000453:epidemiology; D014394:Tuberculosis, Osteoarticular / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology
chemical_list: D001500:BCG Vaccine; D004269:DNA, Bacterial