Calcium signalling: mitofusins promote interorganellar crosstalk.
Juxtaposition of the endoplasmic reticulum with mitochondria facilitates Ca(2+) fluxes between the organelles. However, the molecular basis of interorganellar tethering remains unknown. A recent report has identified a fundamental role for the dynamin-related mitofusins in the tethering mechanism, thereby ensuring rapid and high fidelity Ca(2+) signalling between the organelles.
Parekh
Anant
A
Department of Physiology, Anatomy and Genetics, Oxford University, Parks Road, Oxford, UK. anant.parekh@dpag.ox.ac.uk
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling / Q000502:physiology*; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics / Q000378:metabolism; D034281:Dynamins / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D020558:GTP Phosphohydrolases; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism
D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; C470018:MFN2 protein, human; D034281:Dynamins; D002118:Calcium