Ethnic differences in brain-derived neurotrophic factor Val66Met polymorphism in Croatian and Korean healthy participants.
OBJECTIVE
To compare the frequency of alleles and genotypes in brain-derived neurotrophic factor (BDNF) val66met polymorphism in ethnically homogenous Caucasian (from Croatia) and ethnically homogenous Asian (from South Korea) healthy participants, as inter-population differences in BDNF val66met may be responsible for the divergent findings in genetic and association studies.


METHODS
BDNF val66met was genotyped in 800 (556 Croatian and 244 Korean) healthy participants. Frequencies of alleles and genotypes were evaluated using a chi(2) test.


RESULTS
The frequencies for genotypes (chi(2)2=114.69; P<0.001) and alleles (chi(2)1=120.07; P<0.001) between Korean and Croatian individuals differed significantly, due to significantly lower (46.3% and 19.5%, P<0.001) frequency of "Met" allele and significantly higher (53.7% and 80.5%, P<0.001) frequency of "Val" allele in Croatian than in Korean participants.


CONCLUSIONS
The study found significant ethnic differences in BDNF val66met polymorphism. The most frequent genotype among Korean participants was "Met/Val" and they had similar distribution of "Met" and "Val" alleles. In contrast, the most frequent genotype among Caucasian participants was "Val/Val" and they had different distribution of "Met" and "Val" alleles. These ethnic differences require matching participants for ethnicity in pharmacogenetic studies and in the studies investigating genetic variations in neuropsychiatric disorders.
Pivac
Nela
N
Laboratory for Molecular Neuropsychiatry, Division of Molecular Medicine, Rudjer Bosković Institute, 10002 Zagreb, Croatia. npivac@irb.hr
Kim
Byungsu
B
Nedić
Gordana
G
Joo
Yeon Ho
YH
Kozarić-Kovacić
Dragica
D
Hong
Jin Pyo
JP
Muck-Seler
Dorotea
D
D000328:Adult; D000483:Alleles; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D017523:Croatia; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006304:Health Status; D006801:Humans; D007723:Korea; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*
D019208:Brain-Derived Neurotrophic Factor