Electroosmotic flow as a result of buccal iontophoresis--buccal mucosa properties.
The objective of this study was to investigate and to better understand the properties of buccal mucosa as a semipermeable membrane and a portal for drug administration by iontophoretic and electroosmotic means. In vitro experiments showed that buccal mucosa at the pH of about 7.4 behaved as a cation-exchange membrane and non-linear resistor. It had lower resistance and was more permeable for water than a skin. The electroosmotic volume flow through mucosa depended on current density, mucosa resistance and electrolyte concentration. Sodium dodecyl sulfate (in concentration range 0.001-0.005 mol L(-1)) and urea (in concentration range 0.42-1.67 mol L(-1)) did not promote a water transfer through buccal mucosa, however, both substances enhanced flow through the skin.
Moscicka-Studzinska
Aleksandra
A
Faculty of Chemical and Process Engineering, Warsaw University of Technology, Warsaw, Poland. moscicka@ichip.pw.edu.pl
Kijeńska
Ewa
E
Ciach
Tomasz
T
D000278:Administration, Buccal; D000818:Animals; D053841:Electroosmosis / Q000379:methods*; D007478:Iontophoresis / Q000379:methods*; D009061:Mouth Mucosa / Q000737:chemistry / Q000378:metabolism*; D012869:Skin Absorption / Q000502:physiology; D013552:Swine