title: Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trial.
abstract: OBJECTIVE
  To test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer of embryos with a normal chromosomal pattern for the chromosomes studied with preimplantation genetic screening (PGS) compared with patients who had an embryo transfer without PGS.
  
  
  METHODS
  Prospective randomized controlled trial (RCT).
  
  
  METHODS
  Academic tertiary setting.
  
  
  METHODS
  Patients with AMA (> or =35 years).
  
  
  METHODS
  In an RCT, the clinical IR per embryo transferred was compared after embryo transfer on day 5 or 6 between the PGS group (analysis of chromosomes 13, 16, 18, 21, 22, X, and Y) and the Control group without PGS.
  
  
  METHODS
  No differences were observed between the PGS group and the Control group for the clinical IR (15.1%; 14.9%; rate ratio 1.01; exact confidence interval [CI], 0.25-5.27), the ongoing IR (at 12 weeks) (9.4%; 14.9%), and the live born rate per embryo transferred (9.4%; 14.9%; rate ratio 0.63; exact CI, 0.08-3.37). Fewer embryos were transferred in the PGS group (1.6 +/- 0.6) than in the Control group (2.0 +/- 0.6). A normal diploid status was observed in 30.3% of the embryos screened by PGS.
  
  
  CONCLUSIONS
  In this RCT, the results did not confirm the hypothesis that PGS results in improved reproductive outcome in patients with AMA.
authors.affiliation: Leuven University Fertility Center, Leuven, Belgium.
authors.forename: Sophie
authors.initials: S
authors.lastname: Debrock
authors.forename: Cindy
authors.initials: C
authors.lastname: Melotte
authors.forename: Carl
authors.initials: C
authors.lastname: Spiessens
authors.forename: Karen
authors.initials: K
authors.lastname: Peeraer
authors.forename: Evelyne
authors.initials: E
authors.lastname: Vanneste
authors.forename: Luc
authors.initials: L
authors.lastname: Meeuwis
authors.forename: Christel
authors.initials: C
authors.lastname: Meuleman
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Frijns
authors.forename: Joris R
authors.initials: JR
authors.lastname: Vermeesch
authors.forename: Thomas M
authors.initials: TM
authors.lastname: D'Hooghe
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000502:physiology; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology; D008423:Maternal Age; D054315:Oocyte Retrieval; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D006063:Chorionic Gonadotropin