title: Seroprevalence and risk factors of human cytomegalovirus infection in the eastern Chinese population.
abstract: Epidemiology and clinical outcomes of human cytomegalovirus (HCMV) infection are known to vary between countries and are associated with socio-economic background. So far, few data are available from developing countries, where the overall burden of infectious diseases is frequently higher. Therefore, we analyzed the seroprevalence in a population of 3,740 individuals selected randomly from eastern China, aiming to determine the seroprevalence of and risk factors for HCMV infection. The overall seroprevalence was 48.07%, higher in the socioeconomically developing inland districts than in the developed forelands. The seroprevalence in females (54.60%) was significantly higher than that in males (41.58%) (P < 0.001). As for profession, peasants (61.54%) and doctors (68.48%) had a higher seropositive rate than members of other professions (P < 0.0001). A significant association between seroprevalence and increasing age was identified (P < 0.05). Our study might help to identify appropriate populations on which to focus for future HCMV vaccination.
authors.affiliation: Department of Hematology, Qilu Hospital, Shandong University, Jinan, People's Republic of China.
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: Daoxin
authors.initials: D
authors.lastname: Ma
authors.forename: Fuzhong
authors.initials: F
authors.lastname: Xue
authors.forename: Chunyan
authors.initials: C
authors.lastname: Ji
authors.forename: Shukang
authors.initials: S
authors.lastname: Wang
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Zhang
authors.forename: Yabin
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xiuping
authors.initials: X
authors.lastname: Yu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D003586:Cytomegalovirus Infections / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D012737:Sex Factors; D012959:Socioeconomic Factors; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G