Role of anti-MHC class I antibody in facilitating transplant accommodation.
The ligation of MHC class I molecules by class I antibodies on endothelial cells leads to both proliferation and survival signal transduction. This signaling pathway has been implicated in the development of acute and chronic antibody-mediated rejection. The ability of a graft to acquire resistance to immune-mediated graft injury is the basis of accommodation. The mechanisms of MHC class I-induced accommodation are unknown, but under certain circumstances following the ligation of MHC class I molecules by antibodies, the survival pathway is activated. This review explores what is currently known about accommodation and how MHC class I signaling may play a role in the process of enhancing graft survival.
Atz
Mary E
ME
UCLA Immunogenetics Center, Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.
Reed
Elaine F
EF
D000208:Acute Disease; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002908:Chronic Disease; D003165:Complement System Proteins / Q000276:immunology* / Q000378:metabolism; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism; D006084:Graft Rejection / Q000276:immunology* / Q000378:metabolism; D006085:Graft Survival / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology* / Q000378:metabolism; D006789:Host vs Graft Reaction / Q000276:immunology*; D006801:Humans; D015398:Signal Transduction / Q000276:immunology; D014183:Transplantation, Heterologous / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology
D000906:Antibodies; D015395:Histocompatibility Antigens Class I; D003165:Complement System Proteins