Simultaneous determination of cefuroxime axetil and ornidazole in tablet dosage form using reversed-phase high performance liquid chromatography.
A simple, accurate and sensitive reversed-phase high performance liquid chromatographic (RP-HPLC) method for the simultaneous determination of cefuroxime axetil and ornidazole in combined tablet dosage form has been developed. The method was performed with a HiQ-SiL C18 column (250 mm x 4.6 mm) and photodiode array (PDA) detector, using 0.01 mol/L potassium dihydrogen orthophosphate-methanol (56 : 44, v/v) as the mobile phase and tinidazole as the internal standard. Beer's law obeys in the concentration ranges of 5 - 25 microg/mL and 10 - 50 microg/mL for cefuroxime axetil and ornidazole, respectively. The method has been successfully validated statistically and applied for the analysis of the drugs in pharmaceutical formulation.
Ranjane
Poonam N
PN
Department of Pharmaceutical Analysis, A. I. S. S. M. S. College of Pharmacy, Pune-411001, India.
Gandhi
Santosh V
SV
Kadukar
Sayali S
SS
Ranher
Sandeep S
SS
D002444:Cefuroxime / Q000031:analogs & derivatives* / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid / Q000191:economics / Q000379:methods*; D056148:Chromatography, Reverse-Phase / Q000191:economics / Q000379:methods*; D009950:Ornidazole / Q000032:analysis*; D015203:Reproducibility of Results; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D009950:Ornidazole; D002444:Cefuroxime; C040738:cefuroxime axetil