title: Tuberculosis of the breast: analysis of 20 cases and a literature review.
abstract: Tuberculosis (TB) of the breast is a very rare pathology. The clinical presentations of this disease are manifold, often mimicking carcinoma of the breast. We conducted a retrospective analysis of 20 women with TB of the breast receiving care at the mastology clinic at Getúlio Vargas Hospital, PI, Brazil, between 1994 and 2007. The clinical presentation of the disease, the diagnosis and the response to specific treatment were analyzed. Most of the patients were of reproductive age, with the disease affecting the right breast in eleven patients (55%) and the left breast in nine patients (45%). Palpable nodules were present in five patients (25%) and fistulae in 15 (75%). The mean time between onset of symptoms and diagnosis was 7.7 months (range 3-12 months). Skin testing with purified protein derivative of tuberculin was strongly reactive in all patients, six (30%) of whom were breastfeeding. Diagnosis was confirmed by histopathology and all patients were satisfactorily treated with a combination of rifampicin, isoniazid and pyrazinamide. In the present study, TB of the breast presented predominantly as breast abscesses and fistulae and responded satisfactorily to treatment with anti-TB drugs.
authors.affiliation: Department of Gynecology, Hospital Getúlio Vargas, Federal University of Piauí, Teresina, PI, Brazil. beneditoborges@globo.com
authors.forename: B B
authors.initials: BB
authors.lastname: da Silva
authors.forename: P V
authors.initials: PV
authors.lastname: Lopes-Costa
authors.forename: C G
authors.initials: CG
authors.lastname: Pires
authors.forename: J D
authors.initials: JD
authors.lastname: Pereira-Filho
authors.forename: A R
authors.initials: AR
authors.lastname: dos Santos
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D001938:Brazil; D001941:Breast Diseases / Q000188:drug therapy / Q000473:pathology*; D001942:Breast Feeding / Q000706:statistics & numerical data; D004359:Drug Therapy, Combination; D004812:Epidemiologic Methods; D005260:Female; D005402:Fistula / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D011247:Pregnancy; D016896:Treatment Outcome; D014376:Tuberculosis / Q000188:drug therapy / Q000473:pathology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents