title: Interstitial lung disease and sleep: What is known?
abstract: OBJECTIVE
  Pulmonary fibrosis (PF), a group of disorders characterized by progressive scarring of the lung parenchyma, affects over 500,000 Americans. Fatigue is a common and frequently disabling symptom in PF. We have previously described poor subjective sleep quality in this patient population. We sought to ascertain what is known regarding sleep in PF.
  
  
  METHODS
  We reviewed the English language literature for reports on sleep and sleep disorders in patients with PF.
  
  
  RESULTS
  The existing literature is small and heterogeneous with regard to inclusion criteria. There are a number of distinctive changes in sleep architecture associated with PF including decreased REM sleep and increased sleep fragmentation. In addition, there is suggestion of possible sleep disturbances in this population including OSA, although the frequency of such sleep abnormalities as well as predictors of these abnormalities remain uncertain.
  
  
  CONCLUSIONS
  There is significant need for larger studies characterizing sleep in patients with defined PF. These studies are particularly critical given the limited options for therapy in patients with PF and the impact of fatigue in this disorder.
authors.affiliation: Cleveland Clinic, OH, United States.
authors.forename: Shikhar
authors.initials: S
authors.lastname: Agarwal
authors.forename: Brittany
authors.initials: B
authors.lastname: Richardson
authors.forename: Vidya
authors.initials: V
authors.lastname: Krishnan
authors.forename: Hartmut
authors.initials: H
authors.lastname: Schneider
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Collop
authors.forename: Sonye K
authors.initials: SK
authors.lastname: Danoff
mesh_terms: D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D017286:Polysomnography; D012894:Sleep Stages; D012893:Sleep Wake Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology