title: Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein.
abstract: 1. A recombinant adenovirus encoding SARS coronavirus(SARS-CoV) nucleocapsid protein (rAd-N) was constructed. 2. The ability of the rAd-N to induce anti-SARS-CoV N antibody production and cellular immune responses was evaluated in an HLA-A2.1/Kb transgenic mouse model.
authors.affiliation: Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
authors.forename: F W Y
authors.initials: FW
authors.lastname: Sin
authors.forename: S C S
authors.initials: SC
authors.lastname: Cheng
authors.forename: K T
authors.initials: KT
authors.lastname: Chan
authors.forename: L
authors.initials: L
authors.lastname: Meng
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D000917:Antibody Formation; D000086462:Coronavirus Nucleocapsid Proteins; D005260:Female; D005822:Genetic Vectors; D015789:HLA-A2 Antigen / Q000235:genetics*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D019590:Nucleocapsid Proteins / Q000235:genetics / Q000276:immunology*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000086462:Coronavirus Nucleocapsid Proteins; D015789:HLA-A2 Antigen; D019590:Nucleocapsid Proteins; D014765:Viral Vaccines