Chemokines and chemokine receptors: an overview.
Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.
Bonecchi
Raffaella
R
Department of Translational Medicine, University of Milan, IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Italy.
Galliera
Emanuela
E
Borroni
Elena Monica
EM
Corsi
Massimiliano Marco
MM
Locati
Massimo
M
Mantovani
Alberto
A
D000818:Animals; D018925:Chemokines / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D019707:Receptors, Chemokine / Q000502:physiology*
D018925:Chemokines; D019707:Receptors, Chemokine