title: Glycine absorption in operative hysteroscopy: the impact of anesthesia.
abstract: OBJECTIVE
  This study aimed to evaluate the impact of anesthesia on the absorption of glycine in operative hysteroscopy.
  
  
  METHODS
  A retrospective cohort study was performed over 2 years. The absorption of glycine was compared among general anesthesia, local anesthesia with intravenous sedation, and spinal anesthesia. Multiple logistic regression analyses were performed.
  
  
  RESULTS
  In all, 282 operative hysteroscopies were reviewed. The median absorption was 145 mL (10th-90th centile: 0-963 mL) for general anesthesia, 35 mL (10th-90th centile: 0-389 mL) for local anesthesia, and 100 mL (10th-90th centile: 0-500 mL) for spinal anesthesia (P = .002). In comparison with general anesthesia, local anesthesia was associated with lower rate of absorption of 500-1000 mL (4.2% vs 13.4%) and of 1000-1500 mL (3.6% vs 9.8; P = .002). Laparoscopic tubal ligation performed during the procedure was also associated with higher glycine absorption (odds ratio, 3.63; 95% confidence interval, 1.12-11.84).
  
  
  CONCLUSIONS
  Local anesthesia with sedation is associated with significantly decreased glycine absorption and lower rate of absorption > 500 mL when compared with general anesthesia.
authors.affiliation: Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada.
authors.forename: Marie-Eve
authors.initials: ME
authors.lastname: Bergeron
authors.forename: Christine
authors.initials: C
authors.lastname: Beaudet
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bujold
authors.forename: Caroline
authors.initials: C
authors.lastname: Rhéaume
authors.forename: Pascale
authors.initials: P
authors.lastname: Ouellet
authors.forename: Philippe
authors.initials: P
authors.lastname: Laberge
mesh_terms: D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000772:Anesthesia, Local; D000775:Anesthesia, Spinal; D015331:Cohort Studies; D005260:Female; D005998:Glycine / Q000493:pharmacokinetics*; D006801:Humans; D015907:Hysteroscopy; D016015:Logistic Models; D008875:Middle Aged; D012189:Retrospective Studies; D014592:Uterine Hemorrhage / Q000601:surgery*
chemical_list: D005998:Glycine