[Fatty acid synthase: a new anti-tumor target].
Fatty acid synthase (FASN), an enzyme capable of de novo fatty acid synthesis, is highly expressed and activated in most human carcinomas. FASN is associated with poor prognosis in prostate and breast cancer and its inhibition is selectively cytotoxic to human cancer cells. Thus, FASN and fatty acid metabolism have become an important focus for the diagnostic and treatment of cancer. In this sense, there is an increasing interest in identifying and developing new antitumor compounds that inhibit FASN.
Puig
Teresa
T
Oncología Médica, Instituto Catalán de Oncología (ICO-Girona) Instituto de Investigación Biomédica de Girona (IdIBGi), Hospital Universitari Dr. Josep Trueta, Girona, España. mtpuig@iconcologia.net
Porta
Rut
R
Colomer
Ramon
R
D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D064429:Fatty Acid Synthases / Q000037:antagonists & inhibitors* / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000209:etiology; D011379:Prognosis
D000970:Antineoplastic Agents; D064429:Fatty Acid Synthases