Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).
In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3) cells were incubated with these compounds and the release of beta-hexosaminidase was measured kinetically. The data obtained suggest that ginger rhizomes harbor potent compounds capable of inhibiting allergic reactions and may be useful for the treatment and prevention of allergic diseases.
Chen
Bing-Hung
BH
Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
Wu
Pei-Yu
PY
Chen
Kuan-Ming
KM
Fu
Tzu-Fun
TF
Wang
Hui-Min
HM
Chen
Chung-Yi
CY
D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020939:Zingiber officinale / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D027343:Rhizome / Q000737:chemistry; D013624:Taiwan
D018926:Anti-Allergic Agents; D010636:Phenols