title: Organic synthesis in water: a green protocol for the synthesis of 2-(cyclohexylamino)-3- aryl- indeno[1,2-b]furan-4-ones.
abstract: Aldehydes, 1,3-indandione and cyclohexylisocyanide undergo smooth coupling-cyclization in water to produce the corresponding 2-(cyclohexylamino)-3-aryl- indeno [1,2-b] furan-4-ones in good yields. Water was used as a solvent to avoid the use of other highly toxic and environmentally unfavorable solvents for this synthesis.
authors.affiliation: Department of Chemistry, School of Science, Azzahra University, Vanak, Tehran, Iran. mmh1331@yahoo.com
authors.forename: Majid M
authors.initials: MM
authors.lastname: Heravi
authors.forename: Bita
authors.initials: B
authors.lastname: Baghernejad
authors.forename: Hossein A
authors.initials: HA
authors.lastname: Oskooie
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D003500:Cyclization; D003510:Cyclohexanes / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D055772:Green Chemistry Technology / Q000379:methods*; D007189:Indans / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D003486:Cyanides; D003510:Cyclohexanes; D005663:Furans; D007189:Indans; D014867:Water; C001445:1,3-indandione