title: A correlation found between contact allergy to stent material and restenosis of the coronary arteries.
abstract: BACKGROUND
  Metallic implants, stents, are increasingly being used especially in patients with stenosis of the cardiac vessels. Ten to thirty per cent of the patients suffer from restenosis regardless of aetiology. We have shown increased frequency of contact allergy to stent metals in stented patients.
  
  
  OBJECTIVE
  To we evaluate whether contact allergy to stent material is a risk factor for restenosis.
  
  
  METHODS
  Patients with stainless steel stents, with or without gold plating, were epicutaneously tested and answered a questionnaire. The restenosis rate was evaluated.
  
  
  RESULTS
  We found a correlation between contact allergy to gold, gold stent, and restenosis (OR 2.3, CI 1.0-5.1, P = 0.04). The risk for restenosis was threefold increased when the patient was gold allergic and stented with a gold-plated stent. An increased degree of chest pain in gold-allergic patients stented with gold-plated stent was found.
  
  
  CONCLUSIONS
  We found a correlation between contact allergy to gold, gold-stent, and restenosis. It may be of importance to consider contact allergy when developing new materials for stenting.
authors.affiliation: Department of Occupational and Environmental Dermatology, Malmö University Hospital, Malmö, Sweden. cecilia.svedman@skane.se
authors.forename: Cecilia
authors.initials: C
authors.lastname: Svedman
authors.forename: Susanne
authors.initials: S
authors.lastname: Ekqvist
authors.forename: Halvor
authors.initials: H
authors.lastname: Möller
authors.forename: Jonas
authors.initials: J
authors.lastname: Björk
authors.forename: Carl-Magnus
authors.initials: CM
authors.lastname: Pripp
authors.forename: Birgitta
authors.initials: B
authors.lastname: Gruvberger
authors.forename: Eva
authors.initials: E
authors.lastname: Holmström
authors.forename: Carl-Gunnar
authors.initials: CG
authors.lastname: Gustavsson
authors.forename: Magnus
authors.initials: M
authors.lastname: Bruze
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D016009:Chi-Square Distribution; D003324:Coronary Artery Disease / Q000628:therapy; D023903:Coronary Restenosis / Q000453:epidemiology / Q000209:etiology*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D013193:Stainless Steel / Q000009:adverse effects*; D015607:Stents / Q000009:adverse effects*; D013548:Sweden
chemical_list: D013193:Stainless Steel; D006046:Gold