title: Towards optimized acquisition scheme for multiprojection correlation imaging of breast cancer.
abstract: OBJECTIVE
  Correlation imaging (CI) is a form of multiprojection imaging in which multiple images of a patient are acquired from slightly different angles. Information from these images is combined to make the final diagnosis. A critical factor affecting the performance of CI is its data acquisition scheme, because nonoptimized acquisition may distort pathologic indicators. The authors describe a computer-aided detection (CADe) methodology to optimize the acquisition scheme of CI for superior diagnostic accuracy.
  
  
  METHODS
  Images from 106 subjects were used. For each subject, 25 angular projections of a single breast were acquired. Projection images were supplemented with a simulated 3-mm three-dimensional lesion. Each projection was then processed using a traditional CADe algorithm at high sensitivity, followed by the reduction of false-positives by combining the geometric correlation information available from the multiple images. The performance of the CI system was determined in terms of free-response receiver-operating characteristic curves and the areas under receiver-operating characteristic curves. For optimization, the components of acquisition, such as the number of projections and their angular span, were systematically changed to investigate which of the many possible combinations maximized the obtainable CADe sensitivity and specificity.
  
  
  RESULTS
  The performance of the CI system was improved by increasing the angular span. Increasing the number of angular projections beyond a certain number did not improve performance. Maximum performance was obtained between 7 and 10 projections spanning a maximum angular arc of 45 degrees .
  
  
  CONCLUSIONS
  The findings suggest the existence of an optimum acquisition scheme for CI of the breast. CADe results confirmed earlier predictions on the basis of observer models. An optimized CI system may be an important diagnostic tool for improved breast cancer detection.
authors.affiliation: Department of Radiology, Duke Advanced Imaging Laboratories, Duke University, Durham, NC 27705, USA. asc14@duke.edu
authors.forename: Amarpreet S
authors.initials: AS
authors.lastname: Chawla
authors.forename: Robert S
authors.initials: RS
authors.lastname: Saunders
authors.forename: Swatee
authors.initials: S
authors.lastname: Singh
authors.forename: Joseph Y
authors.initials: JY
authors.lastname: Lo
authors.forename: Ehsan
authors.initials: E
authors.lastname: Samei
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008327:Mammography / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods*; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic