title: [Candiduria in type 2 diabetes mellitus patients and its clinical significance. Candida spp. antifungal susceptibility].
abstract: BACKGROUND
  Candida is frequently seen in urinalysis studies in patients with diabetes mellitus. The objective was to determine the presence and clinical significance of candiduria, and to identify the different isolated Candida species and their in vitro susceptibility pattern to different antifungal agents by means of the broth microdilution method.
  
  
  METHODS
  We studied the urine from 50 type 2 diabetes mellitus (DMT2) patients. 24 patients had controlled DMT2 and 26 non-controlled DMT2.
  
  
  RESULTS
  Twenty-three Candida spp. positive cultures were obtained, of which 17 were obtained from the non-controlled DMT2 patients; 30.7% of the isolates were caused by Candida infection. The main isolated species were C. glabrata (48%) and C. albicans (35%). Itraconazole, amphotericine B, and ketoconazole showed less antifungal activity in C. glabrata isolates, whereas fluconazole and voriconazole displayed higher antifungal activity.
  
  
  CONCLUSIONS
  It is important to search routinely for yeast in the urine of DMT2 patients to detect candidiasis, and to perform antifungal susceptibility tests to Candida isolates in order to establish antifungal therapy for these patients.
authors.affiliation: Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México. angelesmg@liceaga.facmed.unam.mx
authors.forename: Patricia
authors.initials: P
authors.lastname: Manzano-Gayosso
authors.forename: Francisca
authors.initials: F
authors.lastname: Hernández-Hernández
authors.forename: Nancy
authors.initials: N
authors.lastname: Zavala-Velásquez
authors.forename: Luis Javier
authors.initials: LJ
authors.lastname: Méndez-Tovar
authors.forename: J Miguel
authors.initials: JM
authors.lastname: Naquid-Narváez
authors.forename: Josep M
authors.initials: JM
authors.lastname: Torres-Rodríguez
authors.forename: Rubén
authors.initials: R
authors.lastname: López-Martínez
mesh_terms: D000328:Adult; D000368:Aged; D002177:Candidiasis / Q000652:urine*; D003924:Diabetes Mellitus, Type 2 / Q000382:microbiology* / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D014552:Urinary Tract Infections / Q000382:microbiology* / Q000652:urine*