title: Preventing and treating chronic disorders using the modified vaccination technique.
abstract: It is anticipated that the ultimate solution for the prevention and termination of autoimmune disorders will be based on somehow manipulating the cells of the immune system to attain antigen (ag) specific downregulation and termination. In the last few years we have developed a new vaccination technique that we call "modified vaccination technique" (MVT). It has with equal effectiveness both prevented and terminated autoimmune disease causing events in an experimental autoimmune kidney disease model. We expect that our technique will be similarly applicable to the specific treatment and cure of numerous other chronic disorders presently treated only by drugs. The vaccine is composed of two components, an ag and a specific antibody against it. When these are combined at slight ag excess they constitute a vaccine which is capable of treating chronic ailments by redirecting immune response outcomes in the vaccinated host. Both components, like drugs, will have to be produced ex vivo in order to maintain uniformity, safety, efficacy, and specificity.
authors.affiliation: Department of Surgery, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada. barabas@ucalgary.ca
authors.forename: Arpad Zsigmond
authors.initials: AZ
authors.lastname: Barabas
authors.forename: Donald Mackay
authors.initials: DM
authors.lastname: Weir
authors.forename: Chad Douglas
authors.initials: CD
authors.lastname: Cole
authors.forename: Arpad David
authors.initials: AD
authors.lastname: Barabas
authors.forename: Nizar Jacques
authors.initials: NJ
authors.lastname: Bahlis
authors.forename: Richard Milton
authors.initials: RM
authors.lastname: Graeff
authors.forename: Rene
authors.initials: R
authors.lastname: Lafreniere
mesh_terms: D002908:Chronic Disease / Q000517:prevention & control* / Q000628:therapy*; D006801:Humans; D014611:Vaccination