Hypoadiponectinemia: a risk factor for metabolic syndrome.
OBJECTIVE
To find out correlation between plasma adiponectin levels, insulin resistance and IDF criteria of Mets Patients.


METHODS
A case-control study was conducted on Native Javanese people from June 2006 to January 2007 in Outpatients Clinic of Dr Sardjito Hospital. The case group involved patients aged between 20 to 55 years old. The diagnosis of metabolic syndrome was confirmed according to IDF criteria. Patients without metabolic syndrome with matching age and sex,were taken as control group.


RESULTS
there were significant differences between case and control group for BMI (body mass index) (30.2 +/- 4.1 vs 26.9 +/- 4.7 kg/m2), waist circumference (93.5 +/- 7.9 vs 84.4 +/- 11.5 cm), triglyceride (207.4 +/- 101.8 vs. 119.3 +/- 71.5 mg/dL) , HDL cholesterol (48.6 +/- 9.4 vs. 59.9 +/- 11.8m g/dL), systolic blood pressure (132.8 +/- 17.9 mmHg vs 120.6 +/- 13.5 mmHg) and diastolic blood pressure (83.8 +/- 8.5 mmHg vs. 79.4 +/- 10.7), fasting blood glucose (128.3 +/- 40.8 mg/dL vs. 100.7 +/- 29.4 mg/dL), HOMA index (6.7 +/- 17.4 vs. 2.0 +/- 2.0) and adiponectin levels (3.8 +/- 1.4 vs. 5.9 +/- 2.5), respectively. For metabolic syndrome, hypoadiponectinemia showed the OR value of 6.0 (95% CI 2.13 to 16.98); insulin resistance showed the OR value of 5.7 (95% CI 1.3 to 25.02), after adjustment for waist circumference, TG, HLD, blood pressure, fasting blood glucose.


CONCLUSIONS
Hypoadiponectinemia and insulin resistance represent independent risk factors for metabolic syndrome development.
Renaldi
Olly
O
Department of Internal Medicine, Gadjah Mada University, Yogyakarta, Indonesia.
Pramono
Bowo
B
Sinorita
Hemi
H
Purnomo
Luthfan Budi
LB
Asdie
Rizka Humardewayanti
RH
Asdie
Ahmad H
AH
D052242:Adiponectin / Q000097:blood / Q000172:deficiency*; D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D013223:Statistics as Topic; D055815:Young Adult
D052242:Adiponectin