[Serum markers of synovitis and bone metabolism in rheumatoid arthritis].
Matrix metalloproteinase-3 (MMP-3) is a useful marker to evaluate the prognosis of joint destruction in rheumatoid arthritis (RA) . The role of MMP-3 in immune cells, however, remains to be elucidated in the pathogenesis of RA. On the other hand, biologic therapies, including tumor necrosis factor alpha (TNF-alpha) -blocking therapy, has been shown to reduce disease activity measures and joint damage progression ; however, the effects of biologic therapies on systemic osteoporosis remain to be elucidated in RA. In this article, we reviewed the literature on these issues after describing our hypothesis of the pathogenesis of synovitis in RA.
Kotake
Shigeru
S
Institute of Rheumatology, Tokyo Women's Medical University.
Nanke
Yuki
Y
Yago
Toru
T
Yamanaka
Hisashi
H
D000469:Alkaline Phosphatase / Q000097:blood; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D015519:Bone Density; D001862:Bone Resorption; D024042:Collagen Type I / Q000097:blood; D000069448:Denosumab; D000068800:Etanercept; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D000069285:Infliximab; D019278:Matrix Metalloproteinase 3 / Q000097:blood*; D015675:Osteocalcin / Q000097:blood; D010012:Osteogenesis; D010455:Peptides / Q000097:blood; D053245:RANK Ligand / Q000627:therapeutic use; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use; D013585:Synovitis / Q000175:diagnosis* / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D015415:Biomarkers; D024042:Collagen Type I; D007074:Immunoglobulin G; D010455:Peptides; D053245:RANK Ligand; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D000069448:Denosumab; D000069285:Infliximab; D000469:Alkaline Phosphatase; D019278:Matrix Metalloproteinase 3; D000068800:Etanercept