Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. (Bowerbank).
Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. has been conducted. The structure identification was judged based on the spectroscopic data, namely, ultraviolet, MS, one and two-dimensional 1H-NMR and 13C-NMR methods. The cytotoxic constituent was identified as 1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)-5-methyl pyrimidine-2,4(1H,3H)-dione. This constituent hasn't been isolated from sponges as natural product.
Setyowati
E P
EP
Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.
Jenie
U A
UA
Sudarsono
Kardono
L B S
LB
Rahmat
R
R
D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044366:Transition Temperature
C539903:1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)pyrimidine-2,4(1H,3H)-dione; D001688:Biological Products; D003603:Cytotoxins; D005663:Furans; D011743:Pyrimidines; D013941:Thymine