title: A familial case of autoimmune hepatitis.
abstract: Autoimmune hepatitis is a chronic liver disease, and both genetic background and environmental factors are related to its pathogenesis. Here, we report that out of five members of a family with similar human leukocyte antigen haplotypes, two developed autoimmune hepatitis, one was positive for antinuclear antibody, and the remaining two had no features of autoimmunity. The two patients with autoimmune hepatitis had a history of medication use, whereas the other family members did not. Our familial study suggests that in addition to genetic background, medication use and other environmental factors may be related to the onset of autoimmune hepatitis.
authors.affiliation: Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, To-on.
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoshida
authors.forename: Masanori
authors.initials: M
authors.lastname: Abe
authors.forename: Shinya
authors.initials: S
authors.lastname: Furukawa
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Murata
authors.forename: Maho
authors.initials: M
authors.lastname: Hamada
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiasa
authors.forename: Bunzo
authors.initials: B
authors.lastname: Matsuura
authors.forename: Fazle
authors.initials: F
authors.lastname: Akbar
authors.forename: Kojiro
authors.initials: K
authors.lastname: Michitaka
authors.forename: Morikazu
authors.initials: M
authors.lastname: Onji
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D019693:Hepatitis, Autoimmune / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D010375:Pedigree
chemical_list: D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C493960:HLA-DRB1*04:05 antigen