[The absorption kinetics of oleanolic acid self-microemulsion in rat stomach and intestine].
OBJECTIVE
To study the absorption kinetics of oleanolic acid self-microemulsion in rat stomach and intestine.


METHODS
The absorption kinetics were obtained by using the in situ perfusion method in rat. The absorption of drug was determinated by the decrease in stomach and intestine with the HPLC as the detection method.


RESULTS
The absorption percent of oleanolic acid microemulsion for 2 hours was 10.15% in stomach; The absorption rate constants of oleanolic acid microemulsion and micelle were 0.0901/h and 0.0486/h in small intestine, respectively; The best absorption segment in intestine was duodenum, ileum, jejunum and colon by turns.


CONCLUSIONS
The oleanolic acid self-microemulsifying system significantly enhances the absorption of oleanolic acid in the gastrointestinal tract and improves its bioavailability.
Yang
Rui
R
College of Pharmacy, Shandong University, Jinan 250012, China. yxyyr@163.com
Su
Le-Qun
LQ
Huang
Xin
X
D000818:Animals; D003106:Colon / Q000378:metabolism; D016503:Drug Delivery Systems; D004386:Duodenum / Q000378:metabolism; D004655:Emulsions; D005753:Gastric Mucosa / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D008297:Male; D008823:Micelles; D009828:Oleanolic Acid / Q000302:isolation & purification / Q000493:pharmacokinetics*; D010316:Particle Size; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D004655:Emulsions; D008823:Micelles; D009828:Oleanolic Acid