Taking the stress out of melanoma.
A recent study published in Molecular Cell describes a mechanism whereby oncogenic BRAF inhibits AMPK in melanoma cells. This may explain why cancer cells expressing oncogenic BRAF grow under conditions of metabolic stress and may provide new therapeutic opportunities to treat this life-threatening disease.
Martin
Matthew J
MJ
Signal Transduction Team, The Institute of Cancer Research, London SW3 6JB, UK.
Carling
David
D
Marais
Richard
R
D000091162:AMP-Activated Protein Kinase Kinases; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008545:Melanoma / Q000235:genetics / Q000378:metabolism*; D011494:Protein Kinases / Q000378:metabolism*; D048493:Proto-Oncogene Proteins B-raf / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D011494:Protein Kinases; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf; D000091162:AMP-Activated Protein Kinase Kinases