title: Association of HLA-A in autoimmune myasthenia gravis with thymoma.
abstract: We investigated an association of the HLA-A locus in 78 French Caucasian patients with autoimmune myasthenia gravis (MG) and thymic epithelial tumours. The largest effect was a protection associated with HLA-A02 in MG patients with a B2 type thymoma (OR=0.323, 95% CI: 0.113-0.756, P=0.00041). The frequency of HLA-A25 was also increased in the whole group of patients (OR=3.62, 95% CI: 1.62-7.08, P=0.0041). Our findings emphasise the interest of the histological classification in the genetic study of thymomas.
authors.affiliation: Inserm U and Université Paris Descartes, Institut Cochin, Department of Immunology, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Vandiedonck
authors.forename: Colette
authors.initials: C
authors.lastname: Raffoux
authors.forename: Bruno
authors.initials: B
authors.lastname: Eymard
authors.forename: Christine
authors.initials: C
authors.lastname: Tranchant
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Dulmet
authors.forename: Sophie
authors.initials: S
authors.lastname: Krumeich
authors.forename: Philippe
authors.initials: P
authors.lastname: Gajdos
authors.forename: Henri-Jean
authors.initials: HJ
authors.lastname: Garchon
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000097:blood; D004252:DNA Mutational Analysis; D005260:Female; D005602:France; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005828:Genetics, Population; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D006579:Heterozygote; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology*; D013945:Thymoma / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D044465:White People
chemical_list: D001323:Autoantibodies; D005819:Genetic Markers; D015234:HLA-A Antigens; C037019:HLA-A*25 antigen