Efficient system for the preparation of [13N]labeled nitrosamines.
In the present Letter, a fast and reproducible method for the synthesis of N-[(13)N]nitrosamines is reported. The labeling strategy is based on trapping [(13)N]NO2- in an anion exchange resin. The reaction with secondary amines in the presence of Ph(3)P and Br(2) led to the formation of the desired nitrosamines in short reaction times (2 min) with excellent radiochemical conversion (>45%). Final radiotracers were obtained after purification in good radiochemical yields (>30%, decay corrected). Radiochemical purity was above 99% in all cases.
Gómez-Vallejo
Vanessa
V
Radiochemistry Department, CIC biomaGUNE, Parque Tecnológico de San Sebastián, po Miramón 182, Edificio Empresarial C, 20009 San Sebastián, Guipúzcoa, Spain.
Kato
Koichi
K
Hanyu
Masayuki
M
Minegishi
Katsuyuki
K
Borrell
José I
JI
Llop
Jordi
J
D007553:Isotope Labeling / Q000379:methods*; D009590:Nitrogen Radioisotopes / Q000737:chemistry / Q000302:isolation & purification; D009602:Nitrosamines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification
D009590:Nitrogen Radioisotopes; D009602:Nitrosamines