title: Mononuclear Cu(II)-phenolate bioinspired complex is catalytically promiscuous: phosphodiester and peptide amide bond cleavage.
abstract: In this work, the cleavage activity of the metal complex [Cu(C(21)H(21)N(3)O(2))(OH(2))(2)](2+) is demonstrated to occur toward double-stranded DNA, in addition to its previously described amide bond cleavage activity, thus suggesting catalytic promiscuity for this complex.
authors.affiliation: Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, 88040-900 Florianópolis-SC, Brazil.
authors.forename: Mauricio C Bof
authors.initials: MC
authors.lastname: Oliveira
authors.forename: Deise
authors.initials: D
authors.lastname: Mazera
authors.forename: Marciela
authors.initials: M
authors.lastname: Scarpellini
authors.forename: Patricia Cardoso
authors.initials: PC
authors.lastname: Severino
authors.forename: Ademir
authors.initials: A
authors.lastname: Neves
authors.forename: Hernán
authors.initials: H
authors.lastname: Terenzi
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009942:Organometallic Compounds / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry*; D009994:Osmolar Concentration; D010455:Peptides / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry; D013696:Temperature
chemical_list: D000577:Amides; D009942:Organometallic Compounds; D010755:Organophosphates; D010455:Peptides; D010636:Phenols; D003300:Copper; D004247:DNA