title: Neonatal desensitization allows long-term survival of neural xenotransplants without immunosuppression.
abstract: Preclinical development of human cells for potential therapeutic application in neurodegenerative diseases requires that their long-term survival, stability and functional efficacy be studied in animal models of human disease. Here we describe a strategy for long-term immune protection of human fetal and stem cell-derived neural cells transplanted into the adult rat brain, by desensitizing the host rat to similar cells in the neonatal period, without the need for additional immunosuppression.
authors.affiliation: Cardiff University, UK. kellycm@cf.ac.uk
authors.forename: Claire M
authors.initials: CM
authors.lastname: Kelly
authors.forename: Sophie V
authors.initials: SV
authors.lastname: Precious
authors.forename: Caroline
authors.initials: C
authors.lastname: Scherf
authors.forename: Richard
authors.initials: R
authors.lastname: Penketh
authors.forename: Nazar N
authors.initials: NN
authors.lastname: Amso
authors.forename: Alysia
authors.initials: A
authors.lastname: Battersby
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Allen
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Dunnett
authors.forename: Anne E
authors.initials: AE
authors.lastname: Rosser
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000166:cytology* / Q000601:surgery*; D002470:Cell Survival; D002478:Cells, Cultured; D003888:Desensitization, Immunologic / Q000379:methods*; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D009474:Neurons / Q000276:immunology* / Q000637:transplantation*; D051381:Rats; D033581:Stem Cell Transplantation / Q000379:methods*