title: Successful treatment of locally advanced anaplastic thyroid carcinoma by chemotherapy and hyperfractionated radiotherapy.
abstract: The authors report a case of anaplastic thyroid carcinoma which was treated with chemotherapy and radiotherapy and proved to achieve pathological CR (complete response) after a radical operation. A 53-year-old female presented with a mass of about 4 cm in diameter arising from the left lobe of her thyroid and surrounding her cervical esophagus. Pre-operative aspiration cytology and open biopsy revealed the tumor was a giant cell anaplastic carcinoma. There was no sign of distant metastasis. Two cycles of chemotherapy were very effective in treating the tumor but regrowth appeared to occur during hyperfractionated radiotherapy. A radical operation, including a resection of the larynx, cervical trachea and esophagus, was successfully performed and no living cancer cells, only granulation and necrosis, were observed in the operation specimen. The patient has been alive for over 2 years since without any evidence of recurrence.
authors.affiliation: Department of Otolaryngology, Kobe City Medical Center General Hospital, Minatojimanaka-machi 4-6, Chuo-Ku, Kobe, Hyogo 650-0046, Japan. sinosino@kcgh.gr.jp
authors.forename: Shogo
authors.initials: S
authors.lastname: Shinohara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Naito
authors.forename: Keizo
authors.initials: K
authors.lastname: Fujiwara
authors.forename: Shinya
authors.initials: S
authors.lastname: Hori
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Tona
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Ishihara
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D044963:Biopsy, Fine-Needle; D018286:Carcinoma, Giant Cell / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D019583:Dose Fractionation, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D037981:Neck Dissection; D009336:Necrosis; D018714:Radiotherapy, Adjuvant; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D013965:Thyroidectomy
chemical_list: D014408:Biomarkers, Tumor