title: New imidazo[1,2-a]quinoxaline derivatives: synthesis and in vitro activity against human melanoma.
abstract: New imidazo[1,2-a]quinoxaline analogues have been synthesized in good yields via a bimolecular condensation of 2-imidazole carboxylic acid, followed by a coupling with ortho-fluoroaniline and subsequent substitution on the imidazole ring by Suzuki Cross-coupling reaction using microwave assistance. Antitumor activities of these derivatives were evaluated by growth inhibition of A375 cells in vitro. All compounds exhibited high activities compared to imiquimod and fotemustine used as references.
authors.affiliation: EA 4215, Laboratoire de Chimie des Biomolécules et de l'Environnement, Pharmacochimie et Biomolécules, Université Montpellier I, Faculté de Pharmacie, 15 av. Charles Flahault, BP 14491, 34 093 Montpellier Cedex 5, France. carine.masquefa@univ-montp1.fr
authors.forename: Carine
authors.initials: C
authors.lastname: Deleuze-Masquefa
authors.forename: Georges
authors.initials: G
authors.lastname: Moarbess
authors.forename: Sonia
authors.initials: S
authors.lastname: Khier
authors.forename: Nadège
authors.initials: N
authors.lastname: David
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Gayraud-Paniagua
authors.forename: Françoise
authors.initials: F
authors.lastname: Bressolle
authors.forename: Frédéric
authors.initials: F
authors.lastname: Pinguet
authors.forename: Pierre-Antoine
authors.initials: PA
authors.lastname: Bonnet
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D008545:Melanoma / Q000188:drug therapy*; D011810:Quinoxalines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D011810:Quinoxalines; C029899:imidazole