[Combined indicators for diagnosing immune thrombocytopenic purpura].
OBJECTIVE
To search for the best combined indicators for diagnosing immune thrombocytopenic purpura (ITP).


METHODS
Reticulated platelet (RP), thrombopoietin (TPO), platelet-associated immunoglobulins (PAIgG, by ELISA), mean platelet volume (MPV), platelet distribution width (PDW), platelet-large cell ratio(P-LCR) by flow cytometry), and automated blood cytometer were tested in three groups of people: patients with ITP (n=45), healthy people (n=45), and patients without ITP (n=42). Receiver operating characteristic (ROC) curve, LSD-t test, logistic regression, and correlation analysis were performed to identify the best indicators for diagnosing ITP.


RESULTS
The patients with ITP had higher levels of RP, MPV, PDW, P-LCR, and PAIgG than the healthy people and the patients without ITP (P<0.05). The patients without ITP had higher TPO than the healthy people and the patients with ITP (P<0.05). RP and PAIgG were sensitive indicators to ITP. PR was correlated to the diagnosis of ITP (chi2=10.458, P=0.001).


CONCLUSIONS
Individual indicator has limited diagnostic values for ITP, which could be improved by a combination of the indicators.
Zhou
Jing
J
Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Jiang
Neng-gang
NG
Kuang
Ling-han
LH
Liao
Juan
J
D001323:Autoantibodies / Q000097:blood*; D001792:Blood Platelets / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis* / Q000276:immunology; D012156:Reticulocytes / Q000473:pathology*; D012680:Sensitivity and Specificity
D001323:Autoantibodies; D007074:Immunoglobulin G