title: Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines.
abstract: The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
authors.affiliation: Laboratori de Química Farmacèutica (Unitat Associada al CSIC), Facultat de Farmàcia, and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Diagonal, 643, Barcelona E-08028, Spain.
authors.forename: María D
authors.initials: MD
authors.lastname: Duque
authors.forename: Pelayo
authors.initials: P
authors.lastname: Camps
authors.forename: Lenuta
authors.initials: L
authors.lastname: Profire
authors.forename: Silvia
authors.initials: S
authors.lastname: Montaner
authors.forename: Santiago
authors.initials: S
authors.lastname: Vázquez
authors.forename: Francesc X
authors.initials: FX
authors.lastname: Sureda
authors.forename: Jordi
authors.initials: J
authors.lastname: Mallol
authors.forename: Marta
authors.initials: M
authors.lastname: López-Querol
authors.forename: Lieve
authors.initials: L
authors.lastname: Naesens
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: S Radhika
authors.initials: SR
authors.lastname: Prathalingam
authors.forename: John M
authors.initials: JM
authors.lastname: Kelly
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D018929:Cell Culture Techniques; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000588:Amines; D000998:Antiviral Agents; D016194:Receptors, N-Methyl-D-Aspartate; D014344:Trypanocidal Agents; D000218:Adamantane