Dendritic cell interactions with NK cells from different tissues.
BACKGROUND
In recent years, it has been realized that innate lymphocytes do not act in isolation but potentiate their efficiency by interacting with each other, resulting even in the regulation of adaptive immune response. One such cross-talk exists between dendritic cells (DCs) and natural killer (NK) cells. Here, we summarize recent studies on which subsets of these two innate immune components participate in this interaction, how it influences immune responses, and to which extent similar stimuli are integrated by DCs and NK cells during innate immunity.


CONCLUSIONS
We suggest that this cross-talk should be harnessed by activating both of these innate leucocyte populations with new adjuvant formulations for immunotherapies.
Ferlazzo
Guido
G
Laboratory of Immunology and Biotherapy, Department of Human Pathology, School of Medicine, University of Messina, Policlinico, Via Consolare Valeria, 98125 Messina, Italy. guido.ferlazzo@unime.it
Münz
Christian
C
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D002450:Cell Communication / Q000276:immunology*; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007113:Immunity, Innate; D007167:Immunotherapy; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000276:immunology / Q000473:pathology; D020239:Receptor Cross-Talk / Q000276:immunology; D055607:Receptors, Natural Killer Cell / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology; D051193:Toll-Like Receptors / Q000276:immunology / Q000378:metabolism
D016207:Cytokines; D055607:Receptors, Natural Killer Cell; D051193:Toll-Like Receptors