title: Picomolar sensitivity MRI and photoacoustic imaging of cobalt nanoparticles.
abstract: Multimodality imaging based on complementary detection principles has broad clinical applications and promises to improve the accuracy of medical diagnosis. This means that a tracer particle advantageously incorporates multiple functionalities into a single delivery vehicle. In the present work, we explore a unique combination of MRI and photoacoustic tomography (PAT) to detect picomolar concentrations of nanoparticles. The nanoconstruct consists of ferromagnetic (Co) particles coated with gold (Au) for biocompatibility and a unique shape that enables optical absorption over a broad range of frequencies. The end result is a dual-modality probe useful for the detection of trace amounts of nanoparticles in biological tissues, in which MRI provides volume detection, whereas PAT performs edge detection.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA. bouchard@chem.ucla.edu
authors.forename: Louis-S
authors.initials: LS
authors.lastname: Bouchard
authors.forename: M Sabieh
authors.initials: MS
authors.lastname: Anwar
authors.forename: Gang L
authors.initials: GL
authors.lastname: Liu
authors.forename: Byron
authors.initials: B
authors.lastname: Hann
authors.forename: Z Harry
authors.initials: ZH
authors.lastname: Xie
authors.forename: Joe W
authors.initials: JW
authors.lastname: Gray
authors.forename: Xueding
authors.initials: X
authors.lastname: Wang
authors.forename: Alexander
authors.initials: A
authors.lastname: Pines
authors.forename: Fanqing Frank
authors.initials: FF
authors.lastname: Chen
mesh_terms: D003035:Cobalt; D003952:Diagnostic Imaging / Q000379:methods; D006046:Gold; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053768:Metal Nanoparticles; D012680:Sensitivity and Specificity; D014054:Tomography / Q000379:methods*
chemical_list: D003035:Cobalt; D006046:Gold