title: Interleukin-1beta gene (IL-1beta) polymorphisms (SNP -511 and SNP +3953) in thyroid-associated ophthalmopathy (TAO) among the Polish population.
abstract: OBJECTIVE
  The aim of this study was to evaluate whether the IL-1beta gene could be a genetic marker of the thyroid-associated ophthalmopathy (TAO) development.
  
  
  METHODS
  The IL-1beta gene polymorphisms at -511 and +3953 regions in 117 TAO patients of Polish origin (ATA/NOSPECS class III or greater) and in 106 controls were studied.
  
  
  RESULTS
  We found no significant differences in the frequencies of genotypes and allelic variants for SNP -511 and SNP +3953 between the controls and the studied groups.
  
  
  CONCLUSIONS
  No association between the IL-1beta polymorphisms and the TAO existed, so those polymorphisms are not suitable genetic markers for TAO.
authors.affiliation: Department of Endocrinology, University of Medical Science, Poznan, Poland. K_Lacka@wp.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Lacka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Paradowska
authors.forename: Teresa
authors.initials: T
authors.lastname: Gasinska
authors.forename: Joanna
authors.initials: J
authors.lastname: Soszynska
authors.forename: Hanna
authors.initials: H
authors.lastname: Wichary
authors.forename: Lucyna
authors.initials: L
authors.lastname: Kramer
authors.forename: Jan K
authors.initials: JK
authors.lastname: Lacki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017931:DNA Primers / Q000737:chemistry; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D049970:Graves Ophthalmopathy / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D017931:DNA Primers; D005819:Genetic Markers; D053583:Interleukin-1beta