A myeloproliferative disorder may hide another one.
Chronic myeloproliferative disorders (MPDs) are divided into Philadelphia-positive chronic myeloid leukemia (CML) and Philadelphia-negative disorders including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis (IMF). Concomitance of a CML and another MPD is a rare event. We report here the case of a patient presenting initially with IMF who developed a Philadelphia-positive CML 7 years later. At the time of CML diagnosis, two distinct clones were present, one with a 13q deletion and one with a t(9;22). We raise the problem of a CML developing on an initial IMF, or two MPDs occurring from a common or two different stem cells.
Laibe
Sophy
S
Département de Biopathologie, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille Marseille, France.
Tadrist
Zoulika
Z
Arnoulet
Christine
C
Sainty
Danielle
D
Mozziconacci
Marie-Joëlle
MJ
D000368:Aged; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D008297:Male; D010677:Philadelphia Chromosome; D055728:Primary Myelofibrosis / Q000150:complications* / Q000235:genetics / Q000473:pathology; D013234:Stem Cells / Q000473:pathology; D013997:Time Factors