title: Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
abstract: Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.
authors.affiliation: Laboratory for Health Protection Research, National Institute for Public Health and the Environment, Bilthoven, The Netherlands.
authors.forename: Christine L E
authors.initials: CL
authors.lastname: Siezen
authors.forename: Louis
authors.initials: L
authors.lastname: Bont
authors.forename: Hennie M
authors.initials: HM
authors.lastname: Hodemaekers
authors.forename: Marieke J
authors.initials: MJ
authors.lastname: Ermers
authors.forename: Gerda
authors.initials: G
authors.lastname: Doornbos
authors.forename: Ruben
authors.initials: R
authors.lastname: Van't Slot
authors.forename: Ciska
authors.initials: C
authors.lastname: Wijmenga
authors.forename: Hans C van
authors.initials: HC
authors.lastname: Houwelingen
authors.forename: Jan L L
authors.initials: JL
authors.lastname: Kimpen
authors.forename: Tjeerd G
authors.initials: TG
authors.lastname: Kimman
authors.forename: Barbara
authors.initials: B
authors.lastname: Hoebee
authors.forename: Riny
authors.initials: R
authors.lastname: Janssen
mesh_terms: D051722:ADAM Proteins / Q000235:genetics; D001990:Bronchiolitis, Viral / Q000235:genetics*; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000235:genetics*; D008168:Lung / Q000254:growth & development; D020641:Polymorphism, Single Nucleotide; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D000077293:Receptor, Transforming Growth Factor-beta Type I; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics; D018357:Respiratory Syncytial Virus Infections / Q000235:genetics*; D012307:Risk Factors
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; C000625841:TGFBR1 protein, human; D051722:ADAM Proteins; C450441:ADAM33 protein, human