Furostanol saponins and ecdysones with cytotoxic activity from Helleborus bocconei ssp. intermedius.
Two furostanol saponins helleboroside A (1) and helleboroside B (2) were isolated from the methanol extract of Helleborus bocconei Ten. subsp. intermedius (Guss.) Greuter and Burdet, along with the furospirostanol saponin 4 and two ecdysones: ecdysterone (5) and polypodyne B (6). Compound 2 was enzymatically hydrolysed to give product 3. The biological activity of all compounds was tested against rat C6 glioma cells showing a significant cytotoxicity for compounds 3, 4 and 6.
Rosselli
Sergio
S
Dipartimento di Chimica Organica, Università degli Studi di Palermo, Viale delle Scienze, I-90128 Palermo, Italy. rosselli@unipa.it
Maggio
Antonella
A
Bruno
Maurizio
M
Spadaro
Vivienne
V
Formisano
Carmen
C
Irace
Carlo
C
Maffettone
Carmen
C
Mascolo
Nicola
N
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D004440:Ecdysone / Q000302:isolation & purification* / Q000494:pharmacology; D039322:Helleborus / Q000737:chemistry*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D051381:Rats; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D013261:Sterols; D004440:Ecdysone