title: Haplotype analysis of the engrailed-2 gene in young-onset Parkinson's disease.
abstract: OBJECTIVE
  Engrailed-2 is a homeobox transcription factor that is expressed in mesencephalic dopaminergic neurons from development to adulthood and probably plays an important role in the survival of these neurons.
  
  
  METHODS
  Here, we investigated six single-nucleotide polymorphisms (SNPs) in the promoter region (rs1345514) or transcribed part (rs3735653, rs6460013, rs1861972, rs2361689, and rs3808330) of the engrailed-2 gene, respectively, in 103 discordant pairs with young-onset Parkinson's disease (YOPD).
  
  
  RESULTS
  The nominally significant p values in the single-marker and haplotype-based association analysis were suggestive of an association of SNP rs1345514 with YOPD.
  
  
  CONCLUSIONS
  Altogether, our data suggest the possibility that variations of the engrailed-2 gene are implicated in the development of YOPD, although our results with respect to SNP rs1345514 should be verified in an independent sample.
authors.affiliation: Department of Neurology, Philipps University, Marburg, Germany.
authors.forename: Ida
authors.initials: I
authors.lastname: Rissling
authors.forename: Konstantin
authors.initials: K
authors.lastname: Strauch
authors.forename: Christine
authors.initials: C
authors.lastname: Höft
authors.forename: Wolfgang Hermann
authors.initials: WH
authors.lastname: Oertel
authors.forename: Jens Carsten
authors.initials: JC
authors.lastname: Möller
mesh_terms: D000328:Adult; D017668:Age of Onset; D005260:Female; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D000099266:Engrailed 2 Protein
chemical_list: D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D000099266:Engrailed 2 Protein