title: [Prognostic and survival factors among pediatric patients with ependymomas].
abstract: BACKGROUND
  Ependymomas constitute the third most common intracranial tumors in children. Risk factors include age, location, extent of surgical excision, and radiation therapy. Recently, chromosomal imbalances have been described.
  
  
  OBJECTIVE
  Determine global survival of patients with ependymomas according to different prognostic factors.
  
  
  METHODS
  We reviewed the medical charts of every pediatric patient with ependymoma from 1996 to 2005. Genomic imbalances were determined using comparative genomic hybridization (CGH). Survival was calculated using the Kaplan and Meier method. We used the Log Rank test for each risk factor. Death risk was calculated by odds ratio (OR).
  
  
  RESULTS
  We included 24 patients. Global survival was 58.04%. The presence of chromosomal imbalances, particularly in chromosome 21, significantly affected survival Being under 5 years of age, anaplastic histology, chemotherapy other than ICE (ifosfamida-carboplatin-etoposide) and partial resection increased the risk of death.
  
  
  CONCLUSIONS
  Known risk factors were confirmed in our study, including chromosomal imbalances. We describe a new chromosomal imbalance in chromosome 21 among 30% of study participants.
authors.affiliation: Departamento de Oncología Pediátrica, Unidad Médica de Alta Especialidad (UMAE) Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, México D.F., México. elopezaguilar@hotmail.com
authors.forename: Enrique
authors.initials: E
authors.lastname: López-Aguilar
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Sepúlveda-Vildósola
authors.forename: Yadira
authors.initials: Y
authors.lastname: Betanzos-Cabrera
authors.forename: Graciela
authors.initials: G
authors.lastname: Gascón-Lastiri
authors.forename: Liliana
authors.initials: L
authors.lastname: Ortiz-Suárez
authors.forename: Hugo
authors.initials: H
authors.lastname: Rivera-Márquez
authors.forename: Fernando
authors.initials: F
authors.lastname: Cerecedo-Díaz
authors.forename: Volkmar
authors.initials: V
authors.lastname: Wanzke-Del Angel
authors.forename: Hermilo
authors.initials: H
authors.lastname: De la Cruz-Yáñez
authors.forename: Griselda
authors.initials: G
authors.lastname: Ramírez-Reyes
authors.forename: Diego
authors.initials: D
authors.lastname: Arenas-Aranda
authors.forename: Georgina
authors.initials: G
authors.lastname: Siordia-Reyes
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000401:mortality*; D002648:Child; D002675:Child, Preschool; D004806:Ependymoma / Q000401:mortality*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011379:Prognosis; D015996:Survival Rate