Adjuvant properties of a simplified C32 monomycolyl glycerol analogue.
A simplified C(32) monomycolyl glycerol (MMG) analogue demonstrated enhanced immunostimulatory activity in a dioctadecyl ammonium bromide (DDA)/Ag85B-ESAT-6 formulation. Elevated levels of IFN-gamma and IL-6 were produced in spleen cells from mice immunised with a C(32) MMG analogue comparable activity to the potent Th1 adjuvant, trehalose 6,6'-di-behenate (TDB).
Bhowruth
Veemal
V
School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Minnikin
David E
DE
Agger
Else Marie
EM
Andersen
Peter
P
Bramwell
Vincent W
VW
Perrie
Yvonne
Y
Besra
Gurdyal S
GS
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D007371:Interferon-gamma / Q000276:immunology / Q000378:metabolism; D015850:Interleukin-6 / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D000644:Quaternary Ammonium Compounds / Q000276:immunology; D015854:Up-Regulation; D014611:Vaccination
D000276:Adjuvants, Immunologic; D015850:Interleukin-6; D000644:Quaternary Ammonium Compounds; C015831:dimethyldioctadecylammonium; D007371:Interferon-gamma; D005990:Glycerol