An acute myeloid leukemia M6b blast crisis with giant proerythroblasts in chronic myeloid leukemia.
The case of a 12 yr old female with bcr-abl positive chronic myeloid leukemia who subsequently developed a fatal AML-M6b (pure erythroleukemia) blast crisis is presented. The case is unique for its rarity of occurrence and for the striking resemblance that the circulating proerythroblasts showed to the giant cells characteristically seen in Parvovirus B19-induced acute pure red cell aplasia. This is, to the best of our knowledge, the first description of such cells in a blast crisis of chronic myeloid leukemia.
Sharma
Prashant
P
Department of Pathology, Maulana Azad Medical College and Lok Nayak Hospital, New Delhi, India.
Dhingra
Kajal Kiran
KK
Roy
Somak
S
Singh
Tejinder
T
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001752:Blast Crisis / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D001803:Blood Transfusion; D002648:Child; D004900:Erythroblasts / Q000473:pathology*; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use; D007150:Immunohistochemistry; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D009378:Neoplasms, Multiple Primary / Q000378:metabolism / Q000473:pathology* / Q000628:therapy
D000970:Antineoplastic Agents; D006918:Hydroxyurea