title: Endoscopic management of large colorectal polyps.
abstract: OBJECTIVE
  The optimal treatment for large colorectal polyps (LCPs) is still a controversial issue. The aim of this study was to evaluate the safety and effectiveness of endoscopic polypectomy (EP) of colorectal polyps >or=2 cm in size.
  
  
  METHODS
  One hundred fifty-one EP LCPs were performed over a period of 7 years. Diathermal snare was used for pedunculated and pseudopedunculated polyps and endoscopic mucosal resection (EMR) or biopsy forceps polypectomy for sessile and flat polyps. The resected polyps were recovered and collected for histology. At scheduled follow-up visits 1, 3, 6, and 12 months after polypectomy, complications and recurrences were recorded in all patients.
  
  
  RESULTS
  Fifteen polyps were located in the rectum, 84 in the sigmoid colon, 11 in the descending colon, four in the splenic flexure, 11 in the transverse colon, 11 in the hepatic flexure, seven in the ascending colon and eight in the cecum. Fifty-six polyps were sessile, 54 pedunculated, 25 pseudopedunculated, and 16 flat. At histology, most of polyps (131) were adenomas (nine with adenocarcinoma in situ). Five were invasive polypoid carcinomas and required colonic resection. Immediate bleeding occurred in ten patients (7.6%) and it was stopped by endoscopic hemoclips (7), epinephrine injection (1), or surgery (2). There were three perforations (2.3%; all polypoid carcinomas), managed endoscopically (1) or surgically (2). Delayed bleeding occurred in two patients (1.5%) and was treated by endoscopic diathermy and hemoclips (1) or surgery (1). During follow-up, six (4.6%) incompletely excised polyps and three (2.3%) relapses in the site of previous EP were detected and endoscopically removed.
  
  
  CONCLUSIONS
  EP is relatively safe and effective for benign-appearing LCPs.
authors.affiliation: Department of Emergency and Organ Transplantation, General Surgery and Liver Transplantation Units-University of Bari, Policlinico, Bari, Italy.
authors.forename: Onofrio
authors.initials: O
authors.lastname: Caputi Iambrenghi
authors.forename: Ippazio
authors.initials: I
authors.lastname: Ugenti
authors.forename: Gennaro
authors.initials: G
authors.lastname: Martines
authors.forename: Fabio
authors.initials: F
authors.lastname: Marino
authors.forename: Donato
authors.initials: D
authors.lastname: Francesco Altomare
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Memeo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003111:Colonic Polyps / Q000473:pathology / Q000601:surgery*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000473:pathology* / Q000601:surgery*