title: Absolute quantification of cerebral blood flow in neurologically normal volunteers: dynamic-susceptibility contrast MRI-perfusion compared with computed tomography (CT)-perfusion.
abstract: To improve the reproducibility of arterial input function (AIF) registration and absolute cerebral blood flow (CBF) quantification in dynamic-susceptibility MRI-perfusion (MRP) at 1.5T, we rescaled the AIF by use of a venous output function (VOF). We compared CBF estimates of 20 healthy, elderly volunteers, obtained by computed tomography (CT)-perfusion (CTP) and MRP on two consecutive days. MRP, calculated without the AIF correction, did not result in any significant correlation with CTP. The rescaled MRP showed fair to moderate correlation with CTP for the central gray matter (GM) and the whole brain. Our results indicate that the method used for correction of partial volume effects (PVEs) improves MRP experiments by reducing AIF-introduced variance at 1.5T.
authors.affiliation: Department of Neuroradiology, Sahlgrenska University Hospital, Gothenburg, Sweden. doerthe.ziegelitz@vgregion.se
authors.forename: Doerthe
authors.initials: D
authors.lastname: Ziegelitz
authors.forename: Göran
authors.initials: G
authors.lastname: Starck
authors.forename: Irene K
authors.initials: IK
authors.lastname: Mikkelsen
authors.forename: Mats
authors.initials: M
authors.lastname: Tullberg
authors.forename: Mikael
authors.initials: M
authors.lastname: Edsbagge
authors.forename: Carsten
authors.initials: C
authors.lastname: Wikkelsö
authors.forename: Eva
authors.initials: E
authors.lastname: Forssell-Aronson
authors.forename: Stig
authors.initials: S
authors.lastname: Holtås
authors.forename: Linda
authors.initials: L
authors.lastname: Knutsson
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D001921:Brain / Q000098:blood supply / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055420:Perfusion Imaging / Q000379:methods*; D012016:Reference Values; D015203:Reproducibility of Results; D012212:Rheology / Q000379:methods; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*