title: Recurrence pattern in glioblastoma multiforme patients treated with anti-angiogenic chemotherapy.
abstract: OBJECTIVE
  Glioblastoma multiforme is the prototype of an angiogenic tumour. Under experimental conditions, anti-angiogenic therapy strategies lead to an increased invasion. Here we report on the pattern of tumour recurrence in glioblastoma patients treated with an anti-angiogenic chemotherapy.
  
  
  METHODS
  A total of 32 patients with glioblastoma multiforme and a residual tumour mass after operation were treated with a continuous low-dose chemotherapy with temozolomide and a COX-II inhibitor, a presumably anti-angiogenic therapy.
  
  
  RESULTS
  While anti-tumour activity of this therapy regimen was excellent with a mean overall time to progression of 10.4 (+/-0.9) months and a mean overall survival of 17.8 (+/-1.5) months, an unusually high rate of distant recurrences was observed (62.5%).
  
  
  CONCLUSIONS
  Patients treated with an anti-angiogenic chemotherapy experience distant recurrences at a higher rate than reported for conventional therapies. This may reflect an anti-angiogenic therapy-induced activation of glioma invasion confirming similar recently published experimental results.
authors.affiliation: Department of Neurosurgery, Universitätsmedizin Mannheim, University of Heidelberg, 68167 Mannheim, Germany. jochen.tuettenberg@nch.ma.uni-heidelberg.de
authors.forename: Jochen
authors.initials: J
authors.lastname: Tuettenberg
authors.forename: Rainer
authors.initials: R
authors.lastname: Grobholz
authors.forename: Marcel
authors.initials: M
authors.lastname: Seiz
authors.forename: Marc A
authors.initials: MA
authors.lastname: Brockmann
authors.forename: Frank
authors.initials: F
authors.lastname: Lohr
authors.forename: Frederik
authors.initials: F
authors.lastname: Wenz
authors.forename: Peter
authors.initials: P
authors.lastname: Vajkoczy
mesh_terms: D000328:Adult; D000368:Aged; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005909:Glioblastoma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000188:drug therapy*; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate
chemical_list: D020533:Angiogenesis Inhibitors