title: Synthesis of quinazolines as tyrosine kinase inhibitors.
abstract: In the present review, the discovery and development of quinazoline as tyrosine kinase inhibitors has been described. The synthesis of most potent quinazoline inhibitors of EGFR, VEGFR and PDGRF has been discussed. Structure activity relationship for quinazoline as tyrosine kinase inhibitors has been established. It was found that C-4, C-6 and C-7 positions in quinazoline are appropriate sites for designing new tyrosine kinase inhibitors. This review should help the medicinal chemist in designing more effective tyrosine kinase inhibitors.
authors.affiliation: Dabur Research Foundation, Sahibabad, Ghaziabad, U.P., India.
authors.forename: Sanjay K
authors.initials: SK
authors.lastname: Srivastava
authors.forename: Vivek
authors.initials: V
authors.lastname: Kumar
authors.forename: Shiv K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: Rama
authors.initials: R
authors.lastname: Mukherjee
authors.forename: Anand C
authors.initials: AC
authors.lastname: Burman
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D011505:Protein-Tyrosine Kinases