Horizontal DNA and mRNA transfer between donor and recipient cells after allogeneic hematopoietic cell transplantation?
Allogeneic hematopoietic cell transplantation in humans results in true biological chimeras. There is now accumulating evidence that besides Graft versus Host Disease (GvHD), there are also other consequences in the co-existence of two genetically distinct populations in the transplant recipient. First, epithelial cells with donor-derived genotype emerge. Second, epithelial tissues of the host acquire genomic alterations. The current review discusses existing data on these recently discovered phenomena and focuses on horizontal gene transfer between donor and recipient cells as a possible mechanism explaining and linking these phenomena.
Waterhouse
Miguel
M
Department of Hematology and Oncology, Albert-Ludwigs University Medical Center, Freiburg, Germany.
Themeli
Maria
M
Metaxas
Yannis
Y
Lagadinou
Eleni D
ED
Finke
Jurgen
J
Spyridonidis
Alexandros
A
D002678:Chimera; D004247:DNA / Q000235:genetics*; D022761:Gene Transfer, Horizontal; D018380:Hematopoietic Stem Cell Transplantation; D012333:RNA, Messenger / Q000235:genetics*; D014019:Tissue Donors; D014184:Transplantation, Homologous
D012333:RNA, Messenger; D004247:DNA