Trimethylsilyl trifluoromethanesulfonate-accelerated addition of catalytically generated zinc acetylides to aldehydes.
In the presence of TMSOTf, a wide variety of terminal acetylenes add rapidly and efficiently to aldehydes via a catalytically generated zinc acetylide. In the absence of TMSOTf, no reaction is observed under otherwise identical conditions.
Downey
C Wade
CW
Gottwald Center for the Sciences, University of Richmond, Richmond, Virginia 23173, USA. wdowney@richmond.edu
Mahoney
Brian D
BD
Lipari
Vincent R
VR