Preimplantation genetic screening for aneuploidy of embryos after in vitro fertilization in women aged at least 35 years: a prospective randomized trial.
OBJECTIVE
To test the hypothesis that patients with advanced maternal age (AMA) have a higher implantation rate (IR) after embryo transfer of embryos with a normal chromosomal pattern for the chromosomes studied with preimplantation genetic screening (PGS) compared with patients who had an embryo transfer without PGS.


METHODS
Prospective randomized controlled trial (RCT).


METHODS
Academic tertiary setting.


METHODS
Patients with AMA (> or =35 years).


METHODS
In an RCT, the clinical IR per embryo transferred was compared after embryo transfer on day 5 or 6 between the PGS group (analysis of chromosomes 13, 16, 18, 21, 22, X, and Y) and the Control group without PGS.


METHODS
No differences were observed between the PGS group and the Control group for the clinical IR (15.1%; 14.9%; rate ratio 1.01; exact confidence interval [CI], 0.25-5.27), the ongoing IR (at 12 weeks) (9.4%; 14.9%), and the live born rate per embryo transferred (9.4%; 14.9%; rate ratio 0.63; exact CI, 0.08-3.37). Fewer embryos were transferred in the PGS group (1.6 +/- 0.6) than in the Control group (2.0 +/- 0.6). A normal diploid status was observed in 30.3% of the embryos screened by PGS.


CONCLUSIONS
In this RCT, the results did not confirm the hypothesis that PGS results in improved reproductive outcome in patients with AMA.
Debrock
Sophie
S
Leuven University Fertility Center, Leuven, Belgium.
Melotte
Cindy
C
Spiessens
Carl
C
Peeraer
Karen
K
Vanneste
Evelyne
E
Meeuwis
Luc
L
Meuleman
Christel
C
Frijns
Jean-Pierre
JP
Vermeesch
Joris R
JR
D'Hooghe
Thomas M
TM
D000328:Adult; D001755:Blastocyst / Q000502:physiology; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005820:Genetic Testing / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D050498:Live Birth / Q000453:epidemiology; D008423:Maternal Age; D054315:Oocyte Retrieval; D011247:Pregnancy; D011446:Prospective Studies
D006063:Chorionic Gonadotropin