Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: experimental models and clinical perspectives.
In this review, we highlight some of recent studies underscoring the importance of the tumor microenvironment, especially the role of bone marrow-derived myeloid cells, in restoring tumor growth after irradiation. Myeloid cells are hematopoietic cells that give rise to monocytes and macrophages in the peripheral blood and tissues. These cells have been shown to be proangiogenic in tumors promoting tumor growth. We also discuss our previously unpublished results on the effect of irradiation on the tumor vasculature including pericyte and basement membrane coverage to the endothelium of tumor blood vessels. We summarize the clinical significance of these studies including the use of MMP-9 inhibitors, administering white blood cell boosters, or planning safety margin of tumor volumes, in order to improve overall clinical benefits in cancer patients treated with radiotherapy.
Ahn
G-One
GO
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford, California, USA.
Brown
J Martin
JM
D000818:Animals; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D006801:Humans; D008264:Macrophages / Q000502:physiology; D061965:Matrix Metalloproteinase Inhibitors; D009000:Monocytes / Q000502:physiology; D022423:Myeloid Cells / Q000502:physiology*; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D014916:Whole-Body Irradiation
D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D042461:Vascular Endothelial Growth Factor A