Human organ/tissue growth algorithms that include obese individuals and black/white population organ weight similarities from autopsy data.
Physiologically based pharmacokinetic (PBPK) models need the correct organ/tissue weights to match various total body weights in order to be applied to children and the obese individual. Baseline data from Reference Man for the growth of human organs (adrenals, brain, heart, kidneys, liver, lungs, pancreas, spleen, thymus, and thyroid) were augmented with autopsy data to extend the describing polynomials to include the morbidly obese individual (up to 250 kg). Additional literature data similarly extends the growth curves for blood volume, muscle, skin, and adipose tissue. Collectively these polynomials were used to calculate blood/organ/tissue weights for males and females from birth to 250 kg, which can be directly used to help parameterize PBPK models. In contrast to other black/white anthropomorphic measurements, the data demonstrated no observable or statistical difference in weights for any organ/tissue between individuals identified as black or white in the autopsy reports.
Young
John F
JF
Division of Personalized Nutrition & Medicine, National Center for Toxicological Research, Jefferson, Arkansas 72079, USA. johnfyoung@aristotle.net
Luecke
Richard H
RH
Pearce
Bruce A
BA
Lee
Taewon
T
Ahn
Hongshik
H
Baek
Songjoon
S
Moon
Hojin
H
Dye
Daniel W
DW
Davis
Thomas M
TM
Taylor
Susan J
SJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001344:Autopsy / Q000706:statistics & numerical data*; D044383:Black People; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000378:metabolism*; D009929:Organ Size / Q000502:physiology*; D012044:Regression Analysis; D044465:White People