title: Coronary CT angiography with dual source computed tomography in 170 patients.
abstract: BACKGROUND
  In preliminary studies DSCT provides robust image quality over a wide range of heart rates and excludes CAD with high accuracy. The aim of the present study was to evaluate the reproducibility of these results in a large, unselected and consecutive group of patients scheduled for invasive coronary angiography (ICA).
  
  
  METHODS
  170 patients (124 men, 46 women; mean age: 64+/-9 years) with known CAD (101 patients) or suspected CAD (69 patients) scheduled for ICA were examined by coronary CTA prior to ICA. All coronary segments were assessed for image quality (1: excellent; 5: non-diagnostic). The presence of significant vessel stenosis (>50%) was calculated using ICA as standard of reference.
  
  
  RESULTS
  A total of 680 vessels were analyzed. Despite of 45 arrythmic patients all analyzed coronary segments were diagnostically evaluable. Mean Agatston score equivalent was 686 (range 0-4950). ICA revealed 364 lesions with > or =50% diameter stenosis. DSCT correctly identified 336 of these lesions. 115 lesions with a diameter stenosis < or =50% were overestimated by DSCT and thus considered as false-positive findings. On a per-segment basis, sensitivity was 92%, specificity 93%, positive predictive value (PPV) was 75% and negative predictive value (NPV) 98%. On a per-vessel basis DSCT revealed a sensitivity of 93%, a specificity of 88%, a PPV of 78% and a NPV of 97%. On a per-patient basis sensitivity was 94%, specificity 79%, PPV 88% and NPV 90%.
  
  
  CONCLUSIONS
  Initial results of preliminary studies showing robust image quality and high accuracy in DSCT cardiac imaging could be approved with the present study enclosing a large consecutive population. However severe coronary calcifications and irregular heart rate still remain limiting factors for coronary CTA. Despite improved image quality and high accuracy of coronary DSCT angiography, proof of indication is necessary, due to still remaining limiting factors.
authors.affiliation: University Hospital of Tuebingen, Department of Diagnostic and Interventional Radiology, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany. ilias.tsiflikas@med.uni-tuebingen.de
authors.forename: Ilias
authors.initials: I
authors.lastname: Tsiflikas
authors.forename: Harald
authors.initials: H
authors.lastname: Brodoefel
authors.forename: Anja J
authors.initials: AJ
authors.lastname: Reimann
authors.forename: Christoph
authors.initials: C
authors.lastname: Thomas
authors.forename: Dominik
authors.initials: D
authors.lastname: Ketelsen
authors.forename: Stephen
authors.initials: S
authors.lastname: Schroeder
authors.forename: Andreas F
authors.initials: AF
authors.lastname: Kopp
authors.forename: Claus D
authors.initials: CD
authors.lastname: Claussen
authors.forename: Christof
authors.initials: C
authors.lastname: Burgstahler
authors.forename: Martin
authors.initials: M
authors.lastname: Heuschmid
mesh_terms: D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed