Passenger lymphocyte syndrome and liver transplantation.
The authors reviewed the passenger lymphocyte syndrome (PLS) that has appeared after transplantation. The definition, mechanism, serological, clinical features, and treatment for PLS after solid organ transplantation, especially liver transplantation, are described. The PLS refers to the clinical phenomenon of alloimmune hemolysis resulting from the adoptive transfer of viable lymphocytes from donor during solid organ or hematopoietic stem cell transplant. Sometimes, it is very severe and may cause "unexplained" hemolysis during the postoperative period. The authors reviewed literature about the PLS in liver transplantation.
Audet
Maxime
M
Centre de Chirurgie Viscérale et de Transplantation, Hôpital de Hautepierre, Hopitaux Universitaires de Strasbourg-Université Louis Pasteur, Strasbourg, France.
Panaro
Fabrizio
F
Piardi
Tullio
T
Huang
Ping
P
Cag
Murat
M
Cinqualbre
Jacques
J
Wolf
Philippe
P
D000017:ABO Blood-Group System / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006087:Graft vs Host Reaction / Q000276:immunology*; D006461:Hemolysis / Q000276:immunology; D006801:Humans; D016031:Liver Transplantation / Q000276:immunology*; D013577:Syndrome; D014184:Transplantation, Homologous / Q000276:immunology
D000017:ABO Blood-Group System