title: Factors influencing the case-fatality rate of Legionnaires' disease.
abstract: METHODS
  The extent of the public health problem posed by Legionnaires' disease (LD) is not always well- appreciated.
  
  
  OBJECTIVE
  To determine the characteristics and factors associated with the case fatality rate (CFR) of LD in Catalonia, Spain.
  
  
  METHODS
  Confirmed cases of LD reported during 1993-2004 were studied. Age, sex, hospitalisation, the type of diagnostic confirmation test and the personal risk factors for LD of cases were collected. Comparative bivariate and multivariate analyses according to origin (community-acquired or nosocomial) and nature (sporadic or outbreaks) were performed.
  
  
  RESULTS
  Of 1938 cases reported, 164 died (case-fatality rate [CFR] 8.5%). The CFR fell from 35% in 1993 to 5.6% in 2004, and was higher in sporadic than in outbreak-associated cases (10% vs. 4.7%) and in nosocomial than community-acquired cases (31.7% vs. 6.8%). In community-acquired cases, the CFR was associated with age >70 years (OR 3.42, 95%CI 2.02-5.79), cancer (OR 4.58, 95%CI 2.36-8.90) and diagnostic confirmation methods other than Legionella urinary antigen test. The CFR of nosocomial cases was not associated with any of these factors.
  
  
  CONCLUSIONS
  The CFR of LD fell during the study period due to the incorporation of new diagnostic techniques and improved detection of outbreaks.
authors.affiliation: Department of Public Health, University of Barcelona, Barcelona, Spain. angela.dominguez@ub.edu
authors.forename: A
authors.initials: A
authors.lastname: Dominguez
authors.forename: J
authors.initials: J
authors.lastname: Alvarez
authors.forename: M
authors.initials: M
authors.lastname: Sabria
authors.forename: G
authors.initials: G
authors.lastname: Carmona
authors.forename: N
authors.initials: N
authors.lastname: Torner
authors.forename: M
authors.initials: M
authors.lastname: Oviedo
authors.forename: J
authors.initials: J
authors.lastname: Cayla
authors.forename: S
authors.initials: S
authors.lastname: Minguell
authors.forename: I
authors.initials: I
authors.lastname: Barrabeig
authors.forename: M
authors.initials: M
authors.lastname: Sala
authors.forename: P
authors.initials: P
authors.lastname: Godoy
authors.forename: N
authors.initials: N
authors.lastname: Camps
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007877:Legionnaires' Disease / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology