Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.
Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.
Xin
Deli
D
Pediatric Department of Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Road, XuanWu District, Beijing 100050, China. xindl48@sina.com.cn
Mi
Zuhuang
Z
Han
Xu
X
Qin
Ling
L
Li
Jing
J
Wei
Tianli
T
Chen
Xiaogeng
X
Ma
Shaojie
S
Hou
Ancun
A
Li
Gui
G
Shi
Dawei
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002681:China; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D011019:Pneumonia, Mycoplasma / Q000382:microbiology; D017354:Point Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D012141:Respiratory Tract Infections / Q000382:microbiology
D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S