Pregnancy and disease outcome in patients with systemic lupus erythematosus (SLE): a study at Srinagarind Hospital.
BACKGROUND
Systemic lupus erythematosus (SLE) is a multi-system involvement autoimmune disease that commonly occurs in childbearing age women. During pregnancy and postpartum period, disease activity may be severe or unchanged. Disease flare during pregnancy consistently affects pregnancy outcome.


OBJECTIVE
To study pregnancy outcomes and predictive factor for disease flare during pregnancy in SLE patients.


METHODS
Retrospective descriptive study was performed The study population was pregnant SLE patients who were treated between January 1997 and December 2006 at Department of Obstetrics-Gynecologic and Medicine, Srinagarind Hospital, Khon Kaen University, Thailand.


RESULTS
The medical records of37 pregnant SLE patients were reviewed Of these, 33 cases gave delivery at Srinagarind Hospital. Mean age was 27.3 +/- 3.26 years, and mean disease duration was 59.67 +/- 38.62 months. Mostly SLE was established before pregnancy; about 10% SLE were firstly recognized during pregnancy During pregnancy, the disease activity was defined active in about two third (25 cases) of the patients. In most cases (60%), disease activity was continued from the pre-pregnancy period. The most common manifestations during pregnancy were lupus nephritis, hemolytic anemia, cutaneous rash, and arthritis respectively. In 40% (10 patients), SLE was severely active but could be controlled with high doses of corticosteroid, two of these required immunosuppressant. Overall live-birth in SLE patients who delivered at Srinagarind Hospital was 72.7%. Among this group, premature labor and intrauterine growth retardation were more commonly found in the patients who had active SLE than who had disease remission throughout pregnancy period with ratio of 4:1 and 7:1 respectively. Pregnancy lost (27.3%) was due to abortion (6 cases) and dead fetus in utero (DFIU; 2 cases) Termination of pregnancy was performed in 10 patients. Indications were severe active lupus (6 cases), DFIU (2 cases), and premature rupture of membrane (1 case). Pregnancy outcome was the best in patients who had inactive disease throughout pregnancy (75%) and worse in groups of patients whose disease flared up (54.5%) or emerged (50%) during pregnancy.


CONCLUSIONS
Even contraception was routinely advised in treating SLE patients, getting pregnant during active disease was eventually found. Lupus nephritis was the most common manifestation. Overall live-birth was 72.7%. Pregnancy lost was due to abortion and dead fetus in utero. Pregnancy outcome was worse in SLE patients who had disease flares up or emerging during pregnancy.
Foocharoen
Chingching
C
Division of Allergy-Immunology-Rheumatology, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. fching@kku.ac.th
Nanagara
Ratanavadee
R
Salang
Lingling
L
Suwannaroj
Siraphop
S
Mahakkanukrauh
Ajanee
A
D000328:Adult; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis; D011295:Prenatal Care; D046188:Protein Modification, Translational; D055815:Young Adult