[Family and polygenic hypercholesteremia: similarities and differencies according to long-term clinical observations].
OBJECTIVE
Detection and analysis of similarities and differences in patients with family and polygenic hypercholesterolemia (FHCE and PHCE).


METHODS
The study included 100 patients with FHCE and 80 PHCE patients with LD-LP cholesterol level at least 4.3 mmol/l (170 mg/dl).


RESULTS
The patients differed by age, gender, severity of hypercholesterolemia, clinical symptoms. Half of PHCE patients had myocardial infarction, 18% had angina pectoris, 29% cerebrovascular events. The disease was asymptomatic in 19% FHCE patients, 33% had myocardial infarction, 15%--angina pectoris, 12%--cerebrovascular events, 9%--aortic problems. Total mortality in both groups was similar--32 and 33%. Long-term treatment with statins reduced lethality twice both in FHCE and PHCE. Adequate statin therapy prolonged life of the patients by 11 years, on the average.


CONCLUSIONS
Regular treatment of patients with hypercholesterolemia reduces lethality and prolong their life span.
Lipovetskiĭ
B M
BM
D000328:Adult; D000367:Age Factors; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D006937:Hypercholesterolemia / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000401:mortality; D006938:Hyperlipoproteinemia Type II / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000401:mortality; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D011973:Receptors, LDL / Q000235:genetics; D012737:Sex Factors; D013997:Time Factors; D055815:Young Adult
D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D008055:Lipids; D011973:Receptors, LDL