Unfinished business: Incomplete laminin processing exposes a tumor target.
The G45 domain of laminin-332 is cleaved in normal tissues but remains in squamous cell carcinomas. Targeting this domain using a G45 antibody reduced in vivo tumor growth and invasion and suggests a role for G45 as a new therapeutic target.
Banyard
Jacqueline
J
Vascular Biology Program, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. jacqueline.banyard@childrens.harvard.edu
D018450:Disease Progression; D006801:Humans; D007797:Laminin / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D009361:Neoplasm Invasiveness; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D007797:Laminin