title: Characteristics of gastric and intestinal mucin phenotypes of gastric carcinoma.
abstract: OBJECTIVE
  To better understand the carcinogenesis pathway in gastric cancer, we investigated the relationship between mucin phenotype and clinicopathologic features.
  
  
  METHODS
  The study was conducted in 203 consecutive patients with newly diagnosed gastric cancer. Sections from representative paraffin blocks of each case were immunostained with human gastric mucin, MUC2, CD10, and paradoxical concanavalin A class III. Gastric cancers were divided into three phenotypes; gastric phenotype (G-type), intestinal phenotype (I-type), and the Null phenotype (N-type). Surrounding non-cancerous mucosa was also phenotyped as G- or I-type.
  
  
  RESULTS
  In G-type surrounding non-cancerous mucosa, I-type cancers were more frequent among the differentiated type gastric cancers whereas G-type cancers were more frequent among the undifferentiated type gastric cancers (p=0.004). As for surrounding non-cancerous mucosa, the G-type mucosa was more frequently seen than the I-type mucosa in incomplete intestinal metaplasia (p<0.001). I-type gastric cancers were more frequent in non-cancerous surrounding mucosa with incomplete intestinal metaplasia, and G-type cancers were more frequent in non-cancerous surrounding mucosa with no intestinal metaplasia (p=0.03).
  
  
  CONCLUSIONS
  G-type gastric cancers may develop in G-type gastric mucosa with incomplete intestinal metaplasia and progress to the G-type undifferentiated carcinomas or the I-type differentiated carcinomas.
authors.affiliation: Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Mabuchi
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Niwa
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hirooka
authors.forename: Naoki
authors.initials: N
authors.lastname: Ohmiya
authors.forename: Akihiro
authors.initials: A
authors.lastname: Itoh
authors.forename: Osamu
authors.initials: O
authors.lastname: Maeda
authors.forename: Takafumi
authors.initials: T
authors.lastname: Ando
authors.forename: Hidemi
authors.initials: H
authors.lastname: Goto
mesh_terms: D000328:Adult; D000368:Aged; D019070:Cell Lineage; D018450:Disease Progression; D005260:Female; D005752:Gastric Mucins / Q000235:genetics; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D009077:Mucins / Q000235:genetics*; D009361:Neoplasm Invasiveness; D010641:Phenotype; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D005752:Gastric Mucins; D009077:Mucins