title: Prevalence of polyomavirus viruria (JC virus/BK virus) in children following liver transplantation.
abstract: BKV infection is a potential cause of renal dysfunction in non-renal organ transplant recipients. JCV is the causative agent of PML. Furthermore, polyomaviruses are tumor inducing viruses and molecular data suggest an association with malignancies among solid organ transplant patients. So far, there are no studies analyzing polyomavirus viruria following Ltx in children. We performed a prospective prevalence study at a mean of 2187 (range 20-5671) days after transplantation in 100 consecutive children admitted for the routine follow-up examination post-Ltx. The urine was screened for BKV and JCV DNA by using PCR in each case. A plasma analysis by PCR was also done if more than 100,000 DNA copies/mL urine were detected. BKV or JCV viruria was found in 19% (n = 19) of our patients. All patients were free of clinical signs of viral infection, PML, or nephropathy. GFR was normal in 97% of patients and we found no statistical difference of kidney function between patients with and without BKV/JCV viruria. The extent of immunosuppressive therapy had no influence on the polyomavirus viruria. Overall, we found a higher prevalence of polyomavirus viruria in our pediatric liver transplant recipients than reported in adult patients.
authors.affiliation: Pediatric Gastroenterology and Hepatology, Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. f.brinkert@uke.uni-hamburg.de
authors.forename: Florian
authors.initials: F
authors.lastname: Brinkert
authors.forename: Andrea
authors.initials: A
authors.lastname: Briem-Richter
authors.forename: Corina
authors.initials: C
authors.lastname: Ilchmann
authors.forename: Markus J
authors.initials: MJ
authors.lastname: Kemper
authors.forename: Rainer
authors.initials: R
authors.lastname: Ganschow
mesh_terms: D000293:Adolescent; D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D004279:DNA, Viral / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007577:JC Virus / Q000235:genetics / Q000302:isolation & purification*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D016133:Polymerase Chain Reaction; D011120:Polyomavirus / Q000235:genetics / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000453:epidemiology* / Q000652:urine / Q000821:virology; D015995:Prevalence; D011446:Prospective Studies; D013997:Time Factors; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000652:urine / Q000821:virology; D014556:Urine / Q000821:virology*; D055815:Young Adult
chemical_list: D004279:DNA, Viral