title: Correlating extent of neuromuscular instability with acetylcholine receptor antibodies.
abstract: In a retrospective study of 86 patients with myasthenia gravis (MG), we correlated the acetylcholine receptor (AChR) antibody titers with single-fiber EMG studies to explore whether a relationship exists between these parameters. We found that the AChR antibody titers correlated significantly with the mean of the mean consecutive difference of orbicularis oculi (OO, P<0.0001) and extensor digitorum communis (EDC, P<0.0001). The correlation was found to be stronger in OO. The antibody titers also correlated with the percentage of potential pairs with increased jitter in both muscles and, again, the correlation was more significant in OO (P<0.0001) than in EDC (P=0.001). We speculate that this relationship is stronger in OO than in the limb muscles, because the architectural and immunological differences in the motor unit render OO more vulnerable and sensitive to disturbances in neuromuscular transmission.
authors.affiliation: Department of Clinical Neurophysiology, West Wing, John Radcliffe Hospital, Headley Way, Oxford OX3 9DU, UK. m.e.farrugia@doctors.org.uk
authors.forename: Maria E
authors.initials: ME
authors.lastname: Farrugia
authors.forename: Saiju
authors.initials: S
authors.lastname: Jacob
authors.forename: Ptolemaios G
authors.initials: PG
authors.lastname: Sarrigiannis
authors.forename: Robin P
authors.initials: RP
authors.lastname: Kennett
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D004576:Electromyography; D005152:Facial Muscles / Q000276:immunology / Q000503:physiopathology; D005260:Female; D005385:Fingers; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000276:immunology / Q000503:physiopathology*; D009157:Myasthenia Gravis / Q000276:immunology* / Q000503:physiopathology*; D011978:Receptors, Nicotinic / Q000276:immunology*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D011978:Receptors, Nicotinic