title: One-year results of total arterial revascularization vs. conventional coronary surgery: CARRPO trial.
abstract: OBJECTIVE
  To investigate clinical and angiographic outcomes after coronary surgery using total arterial revascularization (TAR).
  
  
  RESULTS
  We randomized 331 patients with multivessel or isolated left main disease to TAR [internal thoracic (ITA) and radial arteries] vs. conventional revascularization (CR) using left ITA and vein grafts. The primary angiographic outcome was the patency index: number of patent grafts (<50% stenosed) divided by number of constructed grafts. One-year angiography was complete for 83% of patients. Mean patency index (+/-SD) was 87 +/- 22% in the TAR group and 88 +/- 18% in the conventional group (P = 0.52). In 72% of TAR patients and 67% of the conventional group, all grafts were patent (P = 0.45). Multiple imputation of missing angiographic data did not influence on results. Within 1 year, 37 (23%) TAR patients and 43 (25%) conventional group patients suffered cardiac events (HR 1.09, 95% CI 0.70-1.69, P = 0.70). One patient (0.6%) in the TAR group and two (1.2%) in the conventional group died (P = 1.00).
  
  
  CONCLUSIONS
  Within 1 year post-operatively, TAR seems at least as safe and effective as CR. Prolonged follow-up will reveal whether this is sustained or superior results of TAR can justify a more general use.
authors.affiliation: Department of Cardiothoracic Surgery, The Heart Centre, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. sunedamgaard@dadlnet.dk
authors.forename: Sune
authors.initials: S
authors.lastname: Damgaard
authors.forename: Jørn
authors.initials: J
authors.lastname: Wetterslev
authors.forename: Jens T
authors.initials: JT
authors.lastname: Lund
authors.forename: Nikolaj B
authors.initials: NB
authors.lastname: Lilleør
authors.forename: Mario J
authors.initials: MJ
authors.lastname: Perko
authors.forename: Henning
authors.initials: H
authors.lastname: Kelbaek
authors.forename: Jan K
authors.initials: JK
authors.lastname: Madsen
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Steinbrüchel
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D001026:Coronary Artery Bypass / Q000379:methods* / Q000401:mortality; D023921:Coronary Stenosis / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014654:Vascular Patency