Use of monoclonal antibodies as an effective strategy for treatment of ciguatera poisoning.
Ciguatera is a global food poisoning caused by the consumption of fish that have accumulated sodium channel activator toxins, ciguatoxins. At present, most diagnosed cases of ciguatera are treated with symptomatic and supportive remedies, and no specific therapy has been devised. Here we report that ciguatoxin CTX3C can be effectively neutralized in vitro and in vivo by simultaneous use of two anti-ciguatoxin monoclonal antibodies, providing the first rational approach toward directly preventing and treating ciguatera.
Inoue
Masayuki
M
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. inoue@mol.f.u-tokyo.ac.jp
Lee
Nayoung
N
Tsumuraya
Takeshi
T
Fujii
Ikuo
I
Hirama
Masahiro
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D036841:Ciguatera Poisoning / Q000188:drug therapy*; D002922:Ciguatoxins / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009500:Neutralization Tests
D000911:Antibodies, Monoclonal; D002922:Ciguatoxins