title: Systemic candidiasis and mesenteric mast cell tumor with multiple metastases in a dog.
abstract: A 5-year-old female miniature dachshund presenting with persistent vomiting and diarrhea had two concurrent rare pathological conditions: systemic candidiasis and mesenteric mast cell tumor with multiorgan metastases. Neoplastic mast cells formed mass in the mesentery of the cecal-colonic region and were also found in the liver, spleen, kidneys, lungs, adrenal grands, ovaries, bone marrow and other tissues. The cells had intracytoplasmic granules with metachromasia and were immunohistochemically positive for c-kit and histamine. Granulomatous lesions with fungal organisms were present in the heart, lungs, kidneys, pancreas, subserosal and surrounding adipose tissue of the duodenum, thyroid glands and mesenteric mass, and phagocytosed organisms were detected in the liver and bone marrow. Bacteriologically and immunohistochemically, the fungi were consistent with Candida albicans.
authors.affiliation: Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan. kmatsuda@rakuno.ac.jp
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsuda
authors.forename: Kanako
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Shintaro
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Makiko
authors.initials: M
authors.lastname: Tominaga
authors.forename: Kazuko
authors.initials: K
authors.lastname: Hirayama
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kadosawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Taniyama
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000254:growth & development*; D002177:Candidiasis / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000382:microbiology* / Q000473:pathology; D004285:Dogs; D005260:Female; D012515:Mast-Cell Sarcoma / Q000473:pathology / Q000662:veterinary*; D008643:Mesentery / Q000473:pathology*; D009362:Neoplasm Metastasis / Q000473:pathology