[Gene expression profiling in lung cancer. Experimental research and clinical application].
The microarray technology allows simultaneous analysis of the global gene expression in cells and tissues. In tumor diseases, important transcriptional changes of genes have been unravelled by this method. The resulted gene expression profiles can be used for the prediction of diagnosis, prognosis or therapeutic outcome, as well as for the identification of novel drug targets. Our review depicts state-of-the-art, limitations, translational applications and future directions concerning microarray analyses in lung cancer.
Kuner
R
R
Molekulare Genomanalyse, Deutsches Krebsforschungszentrum, Heidelberg. r.kuner@dkfz.de
Hoffmann
H
H
Sültmann
H
H
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D020732:Cytogenetic Analysis; D003937:Diagnosis, Differential; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis; D011379:Prognosis; D016896:Treatment Outcome
D000970:Antineoplastic Agents