title: Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx.
abstract: Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical office-based laryngoscopy examination is presented. An optical-ballast-based 4f optical relay system is proposed to realize variable working distance with a constant optical delay. In-vivo OCT imaging of the human larynx is demonstrated. Office-based OCT is a promising imaging modality for early laryngeal cancer diagnosis.
authors.affiliation: University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA.
authors.forename: Shuguang
authors.initials: S
authors.lastname: Guo
authors.forename: Lingfeng
authors.initials: L
authors.lastname: Yu
authors.forename: Ali
authors.initials: A
authors.lastname: Sepehr
authors.forename: Jorge
authors.initials: J
authors.lastname: Perez
authors.forename: Jianping
authors.initials: J
authors.lastname: Su
authors.forename: James M
authors.initials: JM
authors.lastname: Ridgway
authors.forename: David
authors.initials: D
authors.lastname: Vokes
authors.forename: Brian J F
authors.initials: BJ
authors.lastname: Wong
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000553:Ambulatory Care / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007830:Larynx / Q000033:anatomy & histology*; D007909:Lenses; D012031:Refractometry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation*