title: Angiotensin-converting enzyme gene and endothelial nitric oxide synthase gene polymorphisms in Behçet's disease with or without ocular involvement.
abstract: OBJECTIVE
  The association of known ACE gene and eNOS gene polymorphisms with BD in a group of Turkish patients with or without ocular involvement has been investigated.
  
  
  METHODS
  The ACE and eNOS gene polymorphisms were investigated in 73 BD patients and 90 controls.
  
  
  RESULTS
  The distrubition of "DD", "ID" and "II" genotypes of the ACE gene were 32 (43.8%), 29 (39.8%) and 12 (16.4%) for BD patients and 32 (35.5%), 35 (38.9%) and 23 (25.6%) for healthy controls. There was no significant difference between the groups (p = 0.140, OR 1.44, CI 0.90-2.30). When Behçet patients with ocular involvement were compared to the control group, statistical significance was found (p = 0.049, OR 2.18, CI 1.00-4.81). The "bb", "ba", and "aa" genotype frequencies of the eNOS gene were 48 (65.8%), 23 (31.5%), and 2 (2.7%) for patients with BD and 75 (83.3%), 15 (16.7%), and 0 (0%) for healthy controls, respectively. The significant difference found in allelic frequencies between the two groups (p = 0.011, OR 2.32, CI 1.11-4.87). When Behçet patients with ocular involvement were compared, sharper statistical significance was found (p = 0.001,OR 4.61,CI 1.85-11.52).
  
  
  CONCLUSIONS
  The ACE gene polymorphism does not play a role in the pathogenesis of BD. The findings of the eNOS gene polymorphisms confirmed the significant association with BD and even more in patients with ocular involvement.
authors.affiliation: Department of Medical Genetics, Medical Faculty Zonguldak, Zonguldak Karaelmas University, 67600 Zonguldak, Turkey. dursuna@karaelmas.edu.tr
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dursun
authors.forename: Hatice Gul
authors.initials: HG
authors.lastname: Durakbasi-Dursun
authors.forename: Recep
authors.initials: R
authors.lastname: Dursun
authors.forename: Savas
authors.initials: S
authors.lastname: Baris
authors.forename: Levent
authors.initials: L
authors.lastname: Akduman
mesh_terms: D001528:Behcet Syndrome / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D015864:Panuveitis / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D031300:Retinal Vasculitis / Q000235:genetics*; D014421:Turkey / Q000453:epidemiology
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III; D007703:Peptidyl-Dipeptidase A