title: One-stage Integra reconstruction in head and neck defects.
abstract: BACKGROUND
  Integra dermal regeneration template - a two-stage, tissue-engineered, artificial skin - was introduced in the UK in May 1996. There were no restrictions on clinical application and a series of applications in reconstructive surgery were undertaken. One case involved a Caucasian lady with a nose tip basal cell carcinoma (BCC) who had a single-stage reconstruction. The 6-year follow-up was remarkable as it showed a scarless repair.
  
  
  OBJECTIVE
  We undertook a clinical evaluation to explore the outcome of one-stage Integra reconstruction in a selected series of Chinese patients.
  
  
  METHODS
  Ten patients (five male and five female; age range: 54-86 years) with complicated or atypical cutaneous lesions involving the head and neck were treated in an outpatient setting.
  
  
  RESULTS
  Pathology revealed eight BCCs, one squamous cell carcinoma (SCC) and one seborrhoeic keratosis. Healing took place either by wound contraction alone or in conjunction with re-epithelialisation. All wounds were fully healed within 6 weeks. Follow-up ranged from 18 to 30 months, and there has been no recurrence of the malignant lesions.
  
  
  CONCLUSIONS
  In selected cases, one-stage reconstruction using Integra can reduce operating time with no delay for frozen section, flap raising or graft harvesting. More immediate postoperative care is needed, but the long-term aesthetic results are uniformly acceptable.
authors.affiliation: Division of Plastic, Reconstructive and Aesthetic Surgery, Department of Surgery, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, SAR. andrewburd@surgery.cuhk.edu.hk
authors.forename: Andrew
authors.initials: A
authors.lastname: Burd
authors.forename: Pauline S Y
authors.initials: PS
authors.lastname: Wong
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D002809:Chondroitin Sulfates; D003094:Collagen; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D017492:Keratosis, Seborrheic / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009668:Nose Diseases / Q000601:surgery*; D012878:Skin Neoplasms / Q000601:surgery*; D014947:Wounds and Injuries / Q000601:surgery*
chemical_list: C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen