title: Recent advances in cell-free PrPSc amplification technique.
abstract: The development of amplification technology for abnormal forms of prion protein in vitro has had a great impact on the field of prion research. This novel technology has generated new possibilities for understanding the molecular basis of prions and for developing an early diagnostic test for prion diseases. This review provides an overview of recent progress in cell-free PrPSc amplification techniques.
authors.affiliation: Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. atarashi@nagasaki-u.ac.jp
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Atarashi
mesh_terms: D000818:Animals; D006801:Humans; D018620:PrPSc Proteins / Q000378:metabolism*; D017096:Prion Diseases / Q000175:diagnosis*; D011328:Prions / Q000235:genetics / Q000378:metabolism; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D018620:PrPSc Proteins; D011328:Prions; D011994:Recombinant Proteins