Genetic polymorphisms of glycine N-acyltransferase in Japanese individuals.
In the present study, we identified 5 novel single nucleotide polymorphisms (SNPs) in the gene ofglycine N-acyltransferase (GlyAT) by resequencing the entire coding region and the exon-intron junctions from 95 Japanese individuals. The allelic frequencies of 5 novel SNPs were 0.016 for -695T>C, 0.021 for -260C>T, 0.005 for 290C>T, 0.005 for 19371G>A, and 0.005 for 21289G>A. Genetic variants of -979C>G and 21409A>G were in perfect linkage disequilibrium with 21364A>G and 21422C>T, respectively. The nonsynonymous SNP, 21289G>A (Arg131His) in exon 5, was also genotyped in 31 Caucasian individuals, but none of them possessed 21289A (131His) allele.
Yamamoto
Akiko
A
Osaka University, Japan.
Nonen
Shinpei
S
Fukuda
Tsuyoshi
T
Yamazaki
Hiroshi
H
Azuma
Junichi
J
D000217:Acyltransferases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D004364:Pharmaceutical Preparations / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide
D004364:Pharmaceutical Preparations; D004247:DNA; D000217:Acyltransferases; C020680:glycine acyltransferase