Long-acting lanreotide in adolescent girls with constitutional tall stature.
OBJECTIVE
The aim of the study was to evaluate the efficacy and safety of lanreotide prolonged release (PR) 30 mg (long-acting lanreotide) in girls with constitutional tall stature (CTS).


METHODS
This open label prospective study included 35 girls (mean age 12.6 years) with CTS and a predicted adult height of >180 cm. Intramuscular injections of lanreotide PR 30 mg were given every 14 days, for a minimum of 12 months and up to 36 months. Adult height was compared with pretreatment predicted height.


RESULTS
The mean predicted adult height was reduced by 3.8 cm (95% CI 3.7-4.9 cm) in the restricted intent-to-treat population. Mean growth velocity decreased from 7.9 +/- 1.5 cm/year at preinclusion to 1.7 +/- 2.3 cm/year at the last visit on treatment (n = 35). Gastrointestinal adverse events and cholelithiasis were reported in 35/37 patients and 5/37 patients, respectively. There was 1 withdrawal due to gastrointestinal disorders.


CONCLUSIONS
Biweekly intramuscular lanreotide PR 30 mg given to girls with CTS after the onset of pubertal development reduced adult height as compared with predicted height. Treatment-associated adverse events were consistent with the overall safety profile of lanreotide 30 mg PR and did not deter most patients from long-term treatment.
Carel
Jean-Claude
JC
Department of Pediatric Endocrinology and Diabetology, INSERM U690 and Centre de Référence des Maladies Endocriniennes Rares de la Croissance, Robert Debré Hospital and University Paris 7 Denis Diderot, Paris, France. jean-claude.carel@inserm.fr
Blumberg
Joëlle
J
Bougeard-Julien
Muriel
M
Rochiccioli
Pierre
P
Chaussain
Jean-Louis
JL
Tauber
Maïthé
M
D000293:Adolescent; D001827:Body Height / Q000187:drug effects; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D005260:Female; D006130:Growth Disorders / Q000188:drug therapy; D006801:Humans; D010456:Peptides, Cyclic / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D013004:Somatostatin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D010456:Peptides, Cyclic; C060347:lanreotide; D013004:Somatostatin