title: Nicolau syndrome induced by intramuscular vitamin K in a premature newborn.
abstract: BACKGROUND
  Nicolau syndrome (NS), also known as livedo-like dermatitis or embolia cutis medicamentosa, is a very rare complication of intramuscular and intraarticular injection of various drugs.
  
  
  METHODS
  We herein report a case of NS developing approximately 2 h after the intramuscular administration of vitamin K1 in an extremely low birth weight premature newborn. To our knowledge, this patient is the youngest case suffering from such a livedoid skin necrosis and the first case of neonatal NS developing due to intramuscular administration of vitamin K1.
authors.affiliation: Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey. esadsena@yahoo.com.tr
authors.forename: Esad
authors.initials: E
authors.lastname: Koklu
authors.forename: Serdar Umit
authors.initials: SU
authors.lastname: Sarici
authors.forename: Demet
authors.initials: D
authors.lastname: Altun
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007273:Injections, Intramuscular; D008297:Male; D012867:Skin / Q000187:drug effects; D017445:Skin Diseases, Vascular / Q000139:chemically induced*; D013577:Syndrome; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000009:adverse effects*; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000009:adverse effects*; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control
chemical_list: D014803:Vitamin B Complex; D014805:Vitamin B 12