title: Four-year clinical update from the American Society of Breast Surgeons MammoSite brachytherapy trial.
abstract: BACKGROUND
  We present a 4-year update on the efficacy, cosmetic results, and complications of MammoSite breast brachytherapy in patients enrolled in the American Society of Breast Surgeons registry trial.
  
  
  METHODS
  A total of 1,449 breasts in 1,440 patients with early stage breast cancer undergoing breast-conserving therapy were treated with adjuvant, accelerated partial breast irradiation (APBI) (34 Gy in 3.4-Gy fractions) delivered with the MammoSite device. The median follow-up period for the entire group was 36.1 months.
  
  
  RESULTS
  The 3-year actuarial rate of ipsilateral breast tumor recurrence was 2.15%. The 3-year actuarial rate of axillary recurrence was .36%. Complication rates were as follows: infection, 9.5%; seroma, 26.8% (symptomatic seroma, 12.7%); and fat necrosis, 2.0%. The percentages of breasts with good or excellent cosmetic results were as follows: 12 months, 95%; 24 months, 94%; 36 months, 94%; and 48 months, 91%.
  
  
  CONCLUSIONS
  Locoregional control, complications, and cosmetic outcomes from MammoSite APBI at the 4-year update are acceptable and similar to results seen with other forms of APBI.
authors.affiliation: Department of Surgical Oncology, The University of Texas MD Anderson, Cancer Center, Houston, TX 77030, USA.
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Nelson
authors.forename: Peter D
authors.initials: PD
authors.lastname: Beitsch
authors.forename: Frank A
authors.initials: FA
authors.lastname: Vicini
authors.forename: Coral A
authors.initials: CA
authors.lastname: Quiet
authors.forename: Delia
authors.initials: D
authors.lastname: Garcia
authors.forename: Howard C
authors.initials: HC
authors.lastname: Snider
authors.forename: Mark A
authors.initials: MA
authors.lastname: Gittleman
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Zannis
authors.forename: Pat W
authors.initials: PW
authors.lastname: Whitworth
authors.forename: Richard E
authors.initials: RE
authors.lastname: Fine
authors.forename: Angela J
authors.initials: AJ
authors.lastname: Keleher
authors.forename: Henry M
authors.initials: HM
authors.lastname: Kuerer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D011446:Prospective Studies; D011879:Radiotherapy Dosage / Q000592:standards; D012307:Risk Factors; D012955:Societies, Medical; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology