The role of WNT in rheumatoid arthritis and its therapeutic implication.
Rheumatoid arthritis (RA) is a systematic inflammatory and intractable disease, which progressively affects multiple joints. Recent findings strongly suggest a key role of WNT signaling in the disease initiation and progression. In this review, we discuss the role and possibility of treatment by targeting WNT signaling.
Imai
Kazushi
K
Department of Biochemistry, School of Life Dentistry at Tokyo, The Nippon Dental University, 1-9-20 Fujimi, Chiyoda-ku, Tokyo 102-8159, Japan. kimai@tky.ndu.ac.jp
Chiba
Tadashige
T
Maeda
Genta
G
Morikawa
Masako
M
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000378:metabolism*; D001842:Bone and Bones / Q000166:cytology / Q000378:metabolism; D004967:Estrogens / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013583:Synovial Membrane / Q000166:cytology / Q000378:metabolism; D051153:Wnt Proteins / Q000502:physiology*
D004967:Estrogens; D051153:Wnt Proteins