title: Gait disorders of unknown cause in the elderly: Clinical and MRI findings.
abstract: BACKGROUND
  Disequilibrium of unknown cause in older people has been associated with white matter lesions on neuroimaging studies.
  
  
  OBJECTIVE
  To investigate the relationship between gait and balance problems in the elderly, white matter hyperintensities, and vascular risk factors.
  
  
  METHODS
  We studied clinical and neuroimaging features in 30 people older than 65 years of age with gait disorders of unknown cause and 30 age- and sex-matched controls. Patients and controls underwent the same extensive quantitative test battery. White matter lesions on MRI scans were graded in different brain regions.
  
  
  RESULTS
  History of hypertension was more common among patients than controls (60% vs. 27%, p=0.012). On all scales, patients with gait disorders scored worse than controls. The frequency of white matter lesions was significantly higher in patients than in controls (p<0.001). In a multivariate logistic regression analysis in which diagnosis (patient vs. control) was the dependent variable, there was an association between diagnosis and white matter signal hyperintensity score (p<0.001) and history of hypertension (p=0.039).
  
  
  CONCLUSIONS
  Gait disorders of unknown cause in older people are associated both with white matter lesions on MRI scans and with history of hypertension.
authors.affiliation: Department of Neurology, Hospital Ruber Internacional, Madrid, Spain. ofranch@ruberinternacional.es
authors.forename: Oriol
authors.initials: O
authors.lastname: Franch
authors.forename: Luis
authors.initials: L
authors.lastname: Calandre
authors.forename: Juan
authors.initials: J
authors.lastname: Alvarez-Linera
authors.forename: Elan D
authors.initials: ED
authors.lastname: Louis
authors.forename: Félix
authors.initials: F
authors.lastname: Bermejo-Pareja
authors.forename: Julián
authors.initials: J
authors.lastname: Benito-León
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology*; D002318:Cardiovascular Diseases / Q000150:complications; D016022:Case-Control Studies; D005260:Female; D005684:Gait / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D012307:Risk Factors