title: Blood pressure levels, left ventricular mass and function are correlated with left atrial volume in mild to moderate hypertensive patients.
abstract: Arterial hypertension is associated with an increased risk of atrial fibrillation (AF), and leads to a pronounced increase in morbidity and mortality. Left atrial volume (LAV) is an important prognostic marker in the older populations. The aim of our study was to identify the clinical and echocardiographic determinants of LAV in middle-aged (<70 years old) essential hypertensive patients.We evaluated cardiac structure and function in 458 patients, 394 treated and untreated mild to moderate essential hypertensives patients (mean+/-s.d. age 48.4+/-11.1 years) with no associated clinical condition and 64 normotensive control participants (age 45.7+/-12.8 years; P=0.12). A multivariate analysis was performed to calculate the relative weight of each of the variables considered able to predict LAV. The LAV index (LAVi) was significantly increased in the essential hypertensive group vs the control group and was significantly dependent on blood pressure levels (SBP and DBP, P<0.05 for both) and body mass index (BMI) (P<0.0001). Considering the left ventricular (LV) variables, the LV mass index (LVMI) (R(2)=0.19, P<0.001) and LAV were increased in essential hypertensive patients with left ventricular hypertrophy (LVH), and patients with enlarged LAV showed lower systolic and diastolic function and an increased LVMI. The LAVi is dependent on blood pressure levels and anthropometric variables (age and BMI). Further structural (LVMI) and functional (systolic and diastolic) variables are related to the LAVi; LVMI is the most important variable associated with LAV in mild to moderate essential hypertensive adult patients. These findings highlight the importance of left atrium evaluation in adult, relatively young, essential hypertensive patients.
authors.affiliation: Hypertension Unit, Department of Medicine and Experimental Oncology, Division of Internal Medicine, University of Torino, Torino, Italy. alby.milan@libero.it
authors.forename: A
authors.initials: A
authors.lastname: Milan
authors.forename: M A
authors.initials: MA
authors.lastname: Caserta
authors.forename: A
authors.initials: A
authors.lastname: Dematteis
authors.forename: D
authors.initials: D
authors.lastname: Naso
authors.forename: A
authors.initials: A
authors.lastname: Pertusio
authors.forename: C
authors.initials: C
authors.lastname: Magnino
authors.forename: E
authors.initials: E
authors.lastname: Puglisi
authors.forename: F
authors.initials: F
authors.lastname: Rabbia
authors.forename: N G
authors.initials: NG
authors.lastname: Pandian
authors.forename: P
authors.initials: P
authors.lastname: Mulatero
authors.forename: F
authors.initials: F
authors.lastname: Veglio
mesh_terms: D000328:Adult; D000367:Age Factors; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D001794:Blood Pressure; D015992:Body Mass Index; D016022:Case-Control Studies; D015150:Echocardiography, Doppler; D006325:Heart Atria / Q000000981:diagnostic imaging; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000503:physiopathology; D016014:Linear Models; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D016277:Ventricular Function, Left
chemical_list: D000959:Antihypertensive Agents