Direct amination of azoles via catalytic C-H, N-H coupling.
C-H, N-H Coupling of azoles takes place with several amines in the presence of a copper catalyst to undergo amination at the 2-position. The reaction of benzothiazole with N-methylaniline in the presence of sodium acetate and 20 mol % Cu(OAc)(2) in xylene under an oxygen atmosphere afforded the aminated product in 81% yield.
Monguchi
Daiki
D
Department of Chemical Science and Engineering, Kobe University, 1-1 Rokkodai, Nada, Kobe 657-8501, Japan.
Fujiwara
Taiki
T
Furukawa
Hirotoshi
H
Mori
Atsunori
A