title: Cytotoxic sesquiterpenoids from Winteraceae of Caledonian rainforest.
abstract: One secobutanolide, two butanolides and six drimane sesquiterpenoids were isolated from the bark and leaves of Zygogynum pancheri and Zygogynum acsmithii (Winteraceae) along with six known drimanes, isodrimanial, 1beta-O-p-methoxy-E-cinnamoyl-bemadienolide, 7-ketoisodrimenin, drimenin, polygodial and 1beta-E-cinnamoyl-6alpha-hydroxypolygodial. Their structures were elucidated through analysis of spectroscopic data. Drimane sesquiterpenoids with a dialdehyde function exhibited significant inhibitory activities in the in vitro cytotoxic assays against KB, HL60 and HCT116 cancer cell lines.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences de Sfax, B.P. 802, 3018 Sfax, Tunisia.
authors.forename: Noureddine
authors.initials: N
authors.lastname: Allouche
authors.forename: Cécile
authors.initials: C
authors.lastname: Apel
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Martin
authors.forename: Vincent
authors.initials: V
authors.lastname: Dumontet
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007624:KB Cells; D009510:New Caledonia; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014329:Tropical Climate; D032423:Winteraceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes