title: Amoxicillin may cause molar incisor hypomineralization.
abstract: The etiology of molar incisor hypomineralization (MIH) is unclear. Our hypothesis was that certain antibiotics cause MIH. We examined 141 schoolchildren for MIH and, from their medical files, recorded the use of antibiotics under the age of 4 yrs. MIH was found in 16.3% of children. MIH was more common among those children who had taken, during the first year of life, amoxicillin (OR=2.06; 95% CI, 1.01-4.17) or the rarely prescribed erythromycin (OR=4.14; 95% CI, 1.05-16.4), compared with children who had not received treatment. Mouse E18 teeth were cultured for 10 days with/without amoxicillin at concentrations of 100 microg/mL-4 mg/mL. Amoxicillin increased enamel but not dentin thickness. An altered pattern of amelogenesis may have interfered with mineralization. We conclude that the early use of amoxicillin is among the causative factors of MIH.
authors.affiliation: Health Center, Ylämaa, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Laisi
authors.forename: A
authors.initials: A
authors.lastname: Ess
authors.forename: C
authors.initials: C
authors.lastname: Sahlberg
authors.forename: P
authors.initials: P
authors.lastname: Arvio
authors.forename: P-L
authors.initials: PL
authors.lastname: Lukinmaa
authors.forename: S
authors.initials: S
authors.lastname: Alaluusua
mesh_terms: D000566:Amelogenesis / Q000187:drug effects*; D000658:Amoxicillin / Q000009:adverse effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D002648:Child; D003744:Dental Enamel Hypoplasia / Q000139:chemically induced*; D004917:Erythromycin / Q000009:adverse effects; D005260:Female; D006801:Humans; D007180:Incisor / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008963:Molar / Q000473:pathology; D012189:Retrospective Studies; D014074:Tooth Calcification / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin; D000658:Amoxicillin