Ameliorating effect of capsaicin on alterations in lipid metabolism during mice lung carcinoma.
Spices and vegetables possess antioxidant activity that can be applied for preservation of lipids and lower lipid peroxidation in biological systems. In the present study, we have investigated the effect of capsaicin on lipid metabolism during benzo(a)pyrene induced lung cancer in Swiss albino mice. Benzo(a)pyrene (50 mg/kg wt) induced lung cancer animals showed abnormal changes in the tissue and serum lipids, lipoproteins and lipid metabolizing enzymes. Treatment with capsaicin (10 mg/kg body wt) remarkably attenuated all the above alterations and restored normalcy. These findings reveal the chemomodulatory potential of capsaicin in attenuating the alterations in lipid metabolism during experimental lung carcinogenesis.
Anandakumar
P
P
Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
Jagan
S
S
Kamaraj
S
S
Ramakrishnan
G
G
Clara
J Binu
JB
Pathitha
D
D
Kavitha
T
T
Devaki
T
T
D000818:Animals; D001564:Benzo(a)pyrene; D002211:Capsaicin / Q000008:administration & dosage / Q000627:therapeutic use*; D050356:Lipid Metabolism / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008168:Lung / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism*; D008297:Male; D051379:Mice
D008055:Lipids; D001564:Benzo(a)pyrene; D002211:Capsaicin