title: Internet suicide guidelines: report of a life-threatening poisoning using tobacco extract.
abstract: BACKGROUND
  Severe nicotine intoxication occurred in a patient after ingestion of a tobacco extract made from a recipe found on a freely available Internet site.
  
  
  OBJECTIVE
  To determine the levels of nicotine and cotinine in the plasma of a patient who tried to commit suicide by drinking a highly concentrated tobacco extract.
  
  
  METHODS
  A 67-year-old man tried to commit suicide by following guidelines found on an Internet site. He soaked 300 grams of tobacco for 3 days in water, evaporated most of the extract, and drank the rest of it. He felt sick immediately, with the following signs: respiratory depression, hypothermia, hypersalivation, bradycardia, and myoclonic jerks. Soon after the ingestion he vomited most of the extract. Toxicological analysis revealed potentially life-threatening nicotine and cotinine serum concentrations. Surprisingly, nicotine peak levels (322 microg/L) and cotinine peak levels (9092 microg/L) were reached more than 3 h after ingestion of the extract. Estimated nicotine and cotinine half-lives were 200 min and 1185 min, respectively. Treatment consisted of gastric lavage, ventilation, and monitoring of vital functions. The patient recovered and was discharged from the Emergency Department 4 days later without sequelae.
  
  
  CONCLUSIONS
  Nicotinergic intoxication is not always easy to recognize, and without clues from the patient and the toxicologic analysis, might well have been missed in the present case.
authors.affiliation: Laboratoire National de Santé, Division de Toxicologie, Université du Luxembourg, Luxembourg.
authors.forename: Serge
authors.initials: S
authors.lastname: Schneider
authors.forename: Nico
authors.initials: N
authors.lastname: Diederich
authors.forename: Brice
authors.initials: B
authors.lastname: Appenzeller
authors.forename: Anne
authors.initials: A
authors.lastname: Schartz
authors.forename: Christiane
authors.initials: C
authors.lastname: Lorang
authors.forename: Robert
authors.initials: R
authors.lastname: Wennig
mesh_terms: D000284:Administration, Oral; D000368:Aged; D003866:Depressive Disorder; D006801:Humans; D020407:Internet; D008297:Male; D009538:Nicotine / Q000008:administration & dosage / Q000506:poisoning*; D010936:Plant Extracts / Q000008:administration & dosage / Q000506:poisoning*; D013406:Suicide, Attempted; D014026:Nicotiana / Q000506:poisoning*
chemical_list: D010936:Plant Extracts; D009538:Nicotine