[Combined application of hemodialysis and hemosorption for the treatment of acute cisplatin poisoning].
Overdose of cisplatin, a preparation with potentially high nephrotoxicity results in the damage of renal tubules, development of irreversible acute renal insufficiency, and death. Acute cisplatin poisoning requires maintenance and symptomatic treatment; antidotes are unknown. We report a case of successful therapy of acute cisplatin overdose in a 49 year-old patient by hemodialysis with successive inclusion of a column with hemosorbent before the dialyzer in the extracorporeal contour.
Lebed'kov
E V
EV
Makarov
D V
DV
Sarmanaev
S Kh
SKh
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000628:therapy*; D000970:Antineoplastic Agents / Q000506:poisoning* / Q000627:therapeutic use; D002945:Cisplatin / Q000506:poisoning* / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006464:Hemoperfusion / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods*; D014594:Uterine Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D002945:Cisplatin