Enantioselective desymmetrisation of citric acid catalysed by the substrate-tolerant petrobactin biosynthetic enzyme AsbA.
AsbA catalyses the highly enantioselective desymmetrisation of citric acid via ATP-dependent condensation with spermidine, as well as the condensation of citric acid with several spermidine analogues and the condensation of the citric acid analogue tricarballylic acid with spermidine, suggesting that it may be a useful biocatalyst for asymmetric synthesis.
Oves-Costales
Daniel
D
Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
Song
Lijiang
L
Challis
Gregory L
GL
D001408:Bacillus anthracis / Q000201:enzymology*; D001549:Benzamides / Q000737:chemistry*; D002384:Catalysis; D019343:Citric Acid / Q000737:chemistry*; D015394:Molecular Structure; D013095:Spermidine / Q000737:chemistry; D013237:Stereoisomerism
D001549:Benzamides; C450699:petrobactin; D019343:Citric Acid; D013095:Spermidine