title: Paraneoplastic necrotizing myelopathy in a patient with advanced esophageal cancer: An autopsied case report.
abstract: We report the first autopsied case of paraneoplastic necrotizing myelopathy associated with esophageal cancer in the literature. The patient had acute flaccid paraplegia and urinary retention, and had a good recovery of strength of both legs in response to corticosteroids. MRI showed a characteristic lesion with post-gadolinium enhancement of the cervical to mid-thoracic spinal cord at the onset, which has never been reported. Taken together, these results suggest that there is an underlying autoimmune mechanism in paraneoplastic necrotizing myelopathy.
authors.affiliation: Department of Gastroenterology and Neurology, School of Medicine, Kagawa University, Japan. yurai@med.kagawa-u.ac.jp
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Urai
authors.forename: Kouichi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Mieko
authors.initials: M
authors.lastname: Shimamura
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Ikeda
authors.forename: Masago
authors.initials: M
authors.lastname: Tsukaguchi
authors.forename: Kazushi
authors.initials: K
authors.lastname: Deguchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Touge
authors.forename: Masaki
authors.initials: M
authors.lastname: Ueno
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sakamoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Kuriyama
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kinekawa
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Kurokohchi
authors.forename: Naohito
authors.initials: N
authors.lastname: Uchida
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Masaki
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002574:Cervical Vertebrae; D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D013904:Thoracic Vertebrae