Metabolic syndrome and risk of cancer mortality in men.
BACKGROUND
Metabolic syndrome (MetS) has been linked with an increased risk of developing cancer; however, the association between MetS and cancer mortality remains less clear. Little research has focused on pre-cancer risk factors that may affect the outcome of treatment. The purpose of this study was to examine the association between MetS and all-cancer mortality in men.


METHODS
The participants included 33,230 men aged 20-88 years who were enrolled in the Aerobics Centre Longitudinal Study and who were free of known cancer at the baseline.


RESULTS
At baseline 28% of all the participants had MetS. During an average of 14 years follow-up, there were a total of 685 deaths due to cancer. MetS at baseline was associated with a 56% greater age-adjusted risk in cancer mortality.


CONCLUSIONS
These data show that MetS is associated with an increased risk of all-cause cancer mortality in men. Based on these findings, it is evident that successful interventions should be identified to attenuate the negative effects of MetS.
Jaggers
Jason R
JR
Department of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, United States. jaggersj@gwm.sc.edu
Sui
Xuemei
X
Hooker
Steven P
SP
LaMonte
Michael J
MJ
Matthews
Charles E
CE
Hand
Gregory A
GA
Blair
Steven N
SN
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D008076:Cholesterol, HDL / Q000097:blood; D004812:Epidemiologic Methods; D006801:Humans; D006943:Hyperglycemia / Q000150:complications / Q000401:mortality; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000401:mortality; D008875:Middle Aged; D009369:Neoplasms / Q000097:blood / Q000209:etiology / Q000401:mortality*; D009765:Obesity / Q000150:complications / Q000401:mortality; D013781:Texas / Q000453:epidemiology; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D008076:Cholesterol, HDL; D014280:Triglycerides