title: Overcoming various comorbidities by G-CSF-primed unmanipulated BM SCT in adult patients with AML.
abstract: We examined whether the use of G-CSF-primed unmanipulated bone marrow (pBM) permits successful transplantation in patients with adverse comorbid pretransplantation conditions. A total of 33 patients at variable risk of AML undergoing allogeneic SCT from an HLA-identical sibling participated. The patients suffered from a variety of treatment-related sequelae before SCT and many cases also featured the presence of major organ dysfunction. The median follow-up duration of patients who were among the overall survivors was 58 months (range, 11-125 months). The median number of CD34(+) cells infused was 3.5 x 10(6) per kg (range, 0.8-15.6 x 10(6) per kg). The median number of days for recovery of ANC and platelet count without transfusion was 13 (range, 6-22) and 18 (range, 11-29) days, respectively. Four patients (12%) died due to nonrelapse causes and only one patient developed the same course of infectious complication as before SCT. No particular finding in the context of CMV infection or other post transplant complication was observed. The estimated 10-year overall survival rate was 68%. Our results suggest that the use of pBM allows successful engraftment without increasing complications in patients with various comorbidities before transplantation.
authors.affiliation: Division of Hematology, Department of Internal Medicine, St Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: W-S
authors.initials: WS
authors.lastname: Min
authors.forename: B-S
authors.initials: BS
authors.lastname: Cho
authors.forename: K-S
authors.initials: KS
authors.lastname: Eom
authors.forename: S-Y
authors.initials: SY
authors.lastname: Kim
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Kim
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: C-K
authors.initials: CK
authors.lastname: Min
authors.forename: S-G
authors.initials: SG
authors.lastname: Cho
authors.forename: J-W
authors.initials: JW
authors.lastname: Lee
authors.forename: C-C
authors.initials: CC
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D001835:Body Weight; D001853:Bone Marrow / Q000187:drug effects*; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000379:methods; D015897:Comorbidity; D016001:Confidence Intervals; D046148:Donor Selection; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000517:prevention & control; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000401:mortality / Q000628:therapy*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D035781:Siblings; D016019:Survival Analysis; D013997:Time Factors; D019172:Transplantation Conditioning; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D016179:Granulocyte Colony-Stimulating Factor