[Inhibitory mechanisms of three compounds for chrysotile-induced biological activities].
OBJECTIVE
To study the effects of aluminum citrate (AC), rare earth compounds (REC) and sodium selenite (SS) on the surface elements of chrysotile fibers and the inhibitory mechanisms of three compounds for chrysotile-induced biological activities.


METHODS
After being soaked in 250, 500 and 1000 microg/ml aluminum citrate solutions, 125, 250, 500 and 1000 microg/ml mixed rare earths solutions or 125, 250, 500 and 1000 microg/ml sodium selenite solutions for 10 min or 1 hour, the fabrication and the levels of surface elements of chrysotile fibers were determined.


RESULTS
Aluminum citrate, mixed rare earths or sodium selenite all could be adsorbed by chrysotile fibers. After pretreatment of chrysotile fibers with aluminum citrate, mixed rare earths or sodium selenite solutions for 10 min or 1 hour, the corresponding elements or ion on the surface of chrysotile fibers increased with the increase of concentration of the solutions.


CONCLUSIONS
Pretreatment of chrysotile with aluminum citrate, mixed rare earths or sodium selenite solutions can change the fabrication and the levels of surface elements of chrysotile fibers, and inhibit the biological activities of chrysotile by "sealing" some "active sites" on the surface of chrysotile fibers.
Fan
Jing-Guang
JG
China Academy of Safety Sciences and Technology, Beijing 100029, China.
Wang
Qi-En
QE
D017632:Asbestos, Serpentine / Q000737:chemistry* / Q000633:toxicity; D019343:Citric Acid / Q000737:chemistry*; D008674:Metals, Rare Earth / Q000737:chemistry*; D018038:Sodium Selenite / Q000737:chemistry*
D017632:Asbestos, Serpentine; D008674:Metals, Rare Earth; D019343:Citric Acid; D018038:Sodium Selenite; C455846:aluminum citrate