Analysis of the transforming growth factor beta1 gene -509 C/T polymorphism in patients with advanced-stage endometriosis.
OBJECTIVE
To investigate whether the transforming growth factor beta (TGF-beta) gene -509 C/T polymorphism is associated with susceptibility to advanced-stage endometriosis.


METHODS
Case-control study.


METHODS
University department of obstetrics and gynecology.


METHODS
Women with advanced-stage endometriosis (n = 485) and without endometriosis (n = 352).


METHODS
Genotyping by real-time polymerase chain reaction using a Taqman assay.


METHODS
Genotype distribution and allele frequency of the -509 C/T polymorphism in the TGF-beta1 gene.


RESULTS
The genotype distribution of the TGF-beta1 gene -509 C/T polymorphism in the endometriosis group was not different from that of the control group (CC/CT/TT rates were 29.3%/48.2%/22.5% and 27.3%/50.3%/22.4% for the endometriosis and control groups, respectively). Further subgroup analyses according to the stage of endometriosis or bilaterality of ovarian endometrioma also revealed no significant differences in the genotype distribution between each of the subgroups and the control group.


CONCLUSIONS
These results suggest that the TGF-beta1 -509 C/T polymorphism may not be associated with an increased risk for advanced-stage endometriosis.
Kim
Jin Ju
JJ
Department of Obstetrics and Gynecology, Medical Research Center, Seoul National University College of Medicine, Seoul, South Korea.
Choi
Young Min
YM
Choung
Seon Ha
SH
Yoon
Sang Ho
SH
Lee
Kyu Sup
KS
Ku
Seung Yup
SY
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D018450:Disease Progression; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
D053773:Transforming Growth Factor beta1