title: Adult hippocampal neurogenesis is involved in anxiety-related behaviors.
abstract: Adult hippocampal neurogenesis is a unique example of structural plasticity, the functional role of which has been a matter of intense debate. New transgenic models have recently shown that neurogenesis participates in hippocampus-mediated learning. Here, we show that transgenic animals, in which adult hippocampal neurogenesis has been specifically impaired, exhibit a striking increase in anxiety-related behaviors. Our results indicate that neurogenesis plays an important role in the regulation of affective states and could be the target of new treatments for anxiety disorders.
authors.affiliation: INSERM U862, Neurocenter Magendie, Pathophysiology of Addiction group, Bordeaux, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Revest
authors.forename: D
authors.initials: D
authors.lastname: Dupret
authors.forename: M
authors.initials: M
authors.lastname: Koehl
authors.forename: C
authors.initials: C
authors.lastname: Funk-Reiter
authors.forename: N
authors.initials: N
authors.lastname: Grosjean
authors.forename: P-V
authors.initials: PV
authors.lastname: Piazza
authors.forename: D N
authors.initials: DN
authors.lastname: Abrous
mesh_terms: D000818:Animals; D001007:Anxiety / Q000188:drug therapy / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002452:Cell Count; D002707:Chlordiazepoxide / Q000494:pharmacology; D003863:Depression / Q000503:physiopathology; D004318:Doxycycline / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D055495:Neurogenesis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000235:genetics / Q000378:metabolism
chemical_list: D051028:bcl-2-Associated X Protein; D002707:Chlordiazepoxide; D004318:Doxycycline