title: In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum.
abstract: We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).
authors.affiliation: Departamento de Microbiologia e Parasitologia, Laboratório de Pesquisas Micológicas (LAPEMI), Universidade Federal de Santa Maria (UFSM), Avenida Roraima, 1000, Cidade Universitária, Bairro Camobi, Santa Maria-RS, 97105-900, Brazil.
authors.forename: Ayrton S
authors.initials: AS
authors.lastname: Cavalheiro
authors.forename: Régis A
authors.initials: RA
authors.lastname: Zanette
authors.forename: Tatiana B
authors.initials: TB
authors.lastname: Spader
authors.forename: Luciane
authors.initials: L
authors.lastname: Lovato
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Azevedo
authors.forename: Sonia
authors.initials: S
authors.lastname: Botton
authors.forename: Sydney H
authors.initials: SH
authors.lastname: Alves
authors.forename: Janio M
authors.initials: JM
authors.lastname: Santurio
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology; D000077340:Fluvastatin; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology; D008795:Metronidazole / Q000008:administration & dosage / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000008:administration & dosage / Q000494:pharmacology*; D011775:Pythium / Q000187:drug effects*; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology; D000077291:Terbinafine
chemical_list: D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005229:Fatty Acids, Monounsaturated; D007211:Indoles; D009281:Naphthalenes; D008795:Metronidazole; D000077340:Fluvastatin; D000666:Amphotericin B; D000077291:Terbinafine; D012293:Rifampin; D007052:Ibuprofen