Implication of GAB2 gene polymorphism in Italian patients with Alzheimer's disease.
A common polymorphism (rs2373115) in the GRB-associated binding protein 2 (GAB2) gene has been recently associated with the risk of developing Alzheimer's disease (AD) in 644 apolipoprotein E (ApoE) epsilon4 carriers. In order to assess the involvement of the GAB2 polymorphism in the risk of developing AD, we analyzed the genotype and allele distributions of the GAB2 rs2373115 polymorphism in 579 Italian subjects. Our results support a possible implication of GAB2 genetic variant in AD. However, the observed association was confined to ApoE epsilon4 non-carriers, thus suggesting a possible role of GAB2 as an independent risk factor for AD.
Nacmias
Benedetta
B
Department of Neurological and Psychiatric Sciences, University of Florence and Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Firenze, Italy. nacmias@unifi.it
Tedde
Andrea
A
Bagnoli
Silvia
S
Cellini
Elena
E
Guarnieri
Bianca Maria
BM
Piacentini
Silvia
S
Sorbi
Sandro
S
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012307:Risk Factors
D048868:Adaptor Proteins, Signal Transducing; D001057:Apolipoproteins E; C490895:GAB2 protein, human