[Experimental studies on hypoglycemic effects of total flavonoid from Toona sinensis].
OBJECTIVE
To study hypoglycemic effects of total flavonoid from Toona sinensis (TSTF) on diabetic mice model.


METHODS
To confect alloxan 0.02 g/ml with NS and injected alloxan into abdominal cavity to induce diabetic model, and all rats were fed bid with glucose for 2 consecutive days, then the blood glucose was detected by glucose oxidizes, when hypoglycemic point >11.00 mmol/L the rats were successful model made. 100 model rats were divided into 5 groups as contrast groups (distilled water), model control control groups, hight doses group (0.12 g/kg) and low doses group (0.6 g/kg) of TSTF, positive control groups of phenformin (0.10 g/kg); In addition to set 20 natural rats (distilled water), and all groups were fed qd for 15 consecutive days, and then the blood glucose were detected by glucose oxidizes in the sixteenth day.


RESULTS
The blood glucose levels of the diabetic rats in TSTF groups significantly decreased.


CONCLUSIONS
TSTF can significantly decrease the blood glucose levels of diabetic mice induced by alloxan.
Zhang
Jun-Fang
JF
Depart. of Pharmacy, Guangdong Provincial People's Hospital, Guangzhou 510080, China. johnsonzhang2006@163.com
Yang
Jia-Yu
JY
Wen
Jin
J
Wang
Ding-Yong
DY
Yang
Min
M
Liu
Qiu-Qiong
QQ
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D031587:Cedrela / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation; D051381:Rats
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007004:Hypoglycemic Agents