Tyro3 receptor tyrosine kinases in the heterogeneity of apoptotic cell uptake.
Mononuclear phagocytes comprise a mobile, broadly dispersed and highly adaptable system that lies at the very epicenter of host defense against pathogens and the interplay of the innate and adaptive arms of immunity. Understanding the molecular mechanisms that control the response of mononuclear phagocytes to apoptotic cells and the anti-inflammatory consequences of that response is an important goal with implications for multiple areas of biomedical sciences. This review details current understanding of the heterogeneity of apoptotic cell uptake by different members of the mononuclear phagocyte family in humans and mice. It also recounts the unique role of the Tyro3 family of receptor tyrosine kinases, best characterized for Mertk, in the signal transduction leading both to apoptotic cell ingestion and the anti-inflammatory effects that result.
Curtis
Jeffrey L
JL
Pulmonary and Critical Care Medicine, Department of Veterans Affairs Healthsystem and University of Michigan Health System, Ann Arbor, MI 48105, USA. jlcurtis@umich.edu
Todt
Jill C
JC
Hu
Bin
B
Osterholzer
John J
JJ
Freeman
Christine M
CM
D000818:Animals; D017209:Apoptosis; D006801:Humans; D051379:Mice; D010586:Phagocytes / Q000201:enzymology; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction
D020794:Receptor Protein-Tyrosine Kinases; C084944:TYRO3 protein, human