title: Oxidative stress in response to aerobic and anaerobic power testing: influence of exercise training and carnitine supplementation.
abstract: The purpose of this study is to compare the oxidative stress response to aerobic and anaerobic power testing, and to determine the impact of exercise training with or without glycine propionyl-L-carnitine (GPLC) in attenuating the oxidative stress response. Thirty-two subjects were assigned (double blind) to placebo, GPLC-1 (1g PLC/d), GPLC-3 (3g PLC/d) for 8 weeks, plus aerobic exercise. Aerobic (graded exercise test: GXT) and anaerobic (Wingate cycle) power tests were performed before and following the intervention. Blood was taken before and immediately following exercise tests and analyzed for malondialdehyde (MDA), hydrogen peroxide (H2O2), and xanthine oxidase activity (XO). No interaction effects were noted. MDA was minimally effected by exercise but lower at rest for both GPLC groups following the intervention (p = 0.044). A time main effect was noted for H2O2 (p = 0.05) and XO (p = 0.003), with values increasing from pre- to postexercise. Both aerobic and anaerobic power testing increase oxidative stress to a similar extent. Exercise training plus GPLC can decrease resting MDA, but it has little impact on exercise-induced oxidative stress biomarkers.
authors.affiliation: Cardiorespiratory/Metabolic Laboratory, Department of Health and Sport Sciences, The University of Memphis, Memphis, Tennessee 38152, USA. rbloomer@memphis.edu
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Bloomer
authors.forename: Webb A
authors.initials: WA
authors.lastname: Smith
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002331:Carnitine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D026361:Reactive Nitrogen Species / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000097:blood / Q000378:metabolism; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D014803:Vitamin B Complex; D002331:Carnitine