title: Signet ring cell carcinoma of the appendix manifesting as colonic obstruction and ovarian tumors: report of a case.
abstract: Appendiceal cancer is rare and associated with a poor prognosis because it is usually found at an advanced stage. We report a case of appendiceal adenocarcinoma manifesting as a colonic obstruction with a lower abdominal mass. Laparotomy revealed bilateral ovarian tumors and a small appendiceal tumor with peritoneal metastases. We performed ileocecal resection, colectomy, and oophorectomy, following which a histological diagnosis of signet ring cell carcinoma was made. Immunohistochemical analysis revealed positive expression of cytokeratin 7 and 20, and mucin core protein 2 (MUC2), compatible with appendiceal cancer and Kruckenberg metastases. When a patient is found to have disseminated pelvic signet ring cell carcinoma of unknown origin, the appendix should be considered as a possible primary site.
authors.affiliation: Division of Surgical Oncology and Vascular Surgery, Department of Surgery, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Suzuki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Kazama
authors.forename: Joji
authors.initials: J
authors.lastname: Kitayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uozaki
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Miyata
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Nagawa
mesh_terms: D000368:Aged; D001063:Appendiceal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D015415:Biomarkers / Q000032:analysis; D018279:Carcinoma, Signet Ring Cell / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D015415:Biomarkers