title: [Distribution of hepatitis B virus genotypes and subgenotypes among chronically infected patients in Xinjiang Uighur.].
abstract: OBJECTIVE
  To investigate the distribution of Hepatitis B virus genotypes and subgenotypes among patients with chronic hepatitis B in Xinjiang Uighur.
  
  
  METHODS
  The HBV genotypes and subgenotypes were analyzed by PCR-restriction fragment length polymorphism in 109 patients with chronic hepatitis B.
  
  
  RESULTS
  Two HBV genotypes, genotype C (45.9%) and genotype C/D (29.4%) were prevalent, genotype B (8.3%) and genotype D (16.5%) were also found in Xinjiang Uighur. Genotype C had two subgenotypes, C1 (54%) and C2 (46%). Genotype B had only one subgenotype, i.e. Ba. The subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.
  
  
  CONCLUSIONS
  In Uygurs, the most common HBV genotypes were C and C/D, and the subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.
authors.affiliation: Department of Infectious Diseases, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
authors.forename: Shu-Juan
authors.initials: SJ
authors.lastname: Wen
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Jin-Lin
authors.initials: JL
authors.lastname: Hou
authors.forename: Yue-Xin
authors.initials: YX
authors.lastname: Zhang
authors.forename: Zhan-Hui
authors.initials: ZH
authors.lastname: Wang
authors.forename: Yu-Jian
authors.initials: YJ
authors.lastname: Zheng
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000821:virology; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology