title: Squamous cell carcinoma arising in an ovarian mature cystic teratoma: a case report.
abstract: Malignant transformation in a mature cystic teratoma of the ovary is rare. The most common malignancy is squamous cell carcinoma, which consists of about 75% of malignant transformations. In the present report, we describe a case of advanced-stage squamous cell carcinoma arising in a mature cystic teratoma. A postmenopausal 63-year-old woman with squamous cell carcinoma arising in a mature cystic teratoma is presented. The initial investigation by ultrasound showed a left adnexal mass with mixed echo pattern, which arose the suspension of malignancy. She underwent a laparotomy and left oophorectomy. Histopatholog was compatible with squamous cell carcinoma arising in a mature cystic teratoma. After a few episodes of intestinal obstruction and colostomy, she underwent partial resection of the ileum and sigmoid colon four months after the initial oophorectomy. Histopathologic study showed metastatic poorly-differentiated squamous cell carcinoma. Subsequently, she underwent two courses of combination chemotherapy with cisplatin, leucovorin, and 5-fluorouracil with no response. She died from progression of the disease nine months after the initial operation.
authors.affiliation: Department of Pathology, Imam Khomeini Medical Center, Tehran University of Medical Sciences, Tehran, Iran. siamak_shariat@yahoo.com
authors.forename: Siamak
authors.initials: S
authors.lastname: Shariat-Torbaghan
authors.forename: Mohsen
authors.initials: M
authors.lastname: Emami-Aleagha
authors.forename: Sanambar
authors.initials: S
authors.lastname: Sedighi
authors.forename: Farnoosh
authors.initials: F
authors.lastname: Azadbakht
authors.forename: Amir
authors.initials: A
authors.lastname: Keshvari
authors.forename: Behzad
authors.initials: B
authors.lastname: Hajarizadeh
authors.forename: Juan
authors.initials: J
authors.lastname: Rosai
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D003125:Colostomy; D017809:Fatal Outcome; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications / Q000556:secondary / Q000628:therapy; D007415:Intestinal Obstruction / Q000209:etiology / Q000601:surgery; D002955:Leucovorin / Q000627:therapeutic use; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging* / Q000628:therapy; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy; D010052:Ovariectomy; D012811:Sigmoid Neoplasms / Q000150:complications / Q000556:secondary / Q000628:therapy; D013724:Teratoma / Q000000981:diagnostic imaging* / Q000628:therapy; D014463:Ultrasonography; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D014803:Vitamin B Complex; D002945:Cisplatin; D002955:Leucovorin; D005472:Fluorouracil