title: [Association of cathepsin L with coronary heart disease and its risk factors].
abstract: OBJECTIVE
  To explore the relationship of cathepsin L (CatL) with coronary heart disease (CHD), severity of coronary stenosis and risk factors of CHD.
  
  
  METHODS
  A total of 137 CHD patients and 48 controls were included in the study, to determined the serum levels of CatL, high sensitive C reactive protein (hs-CRP), fasting glucose (FBS), total cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1(Apo-A1) and apolipoprotein B. All the subjects were invited for a coronary angiography, using the sum of the Gensini scores to assess the severity of coronary artery stenosis.
  
  
  RESULTS
  Serum CatL levels were significantly higher in CHD patients (5.63 +/= 0.12 microg/L) than non-CHD subjects (3.93 +/= 0.22 microg/L, P<0.01). CatL was an independent risk factor of CHD in Logistic regression analysis [Exp(B)=2.341, 95%CI 1.567 approximately 3.496, P<0.01]. Serum CatL levels were associated positively with the Gensini scores(r=0.228, P<0.01); In fact, CatL was an independent correlator of Gensini scores (P<0.05). CatL inversely associated with HDL-C (r=-0.228, P<0.01) and ApoA1(r=-0.187, P<0.05), and positively with FBS(r=0.161, P<0.05).
  
  
  CONCLUSIONS
  CatL is involved in the pathogenesis of CHD. Serum CatL levels could reflect the severity of coronary luminal narrowings. CatL might participate in glucose and lipid metabolic disorders.
authors.affiliation: Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Yingxian
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiangping
authors.initials: X
authors.lastname: Li
authors.forename: Daoquan
authors.initials: D
authors.lastname: Peng
authors.forename: Zhen
authors.initials: Z
authors.lastname: Tan
authors.forename: Hongmin
authors.initials: H
authors.lastname: Liu
authors.forename: Yingnan
authors.initials: Y
authors.lastname: Qin
authors.forename: Yanqiong
authors.initials: Y
authors.lastname: Xue
mesh_terms: D016022:Case-Control Studies; D056668:Cathepsin L / Q000097:blood*; D003327:Coronary Disease / Q000097:blood* / Q000473:pathology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D056668:Cathepsin L