title: Development of imipenem resistance in an Aeromonas veronii biovar sobria clinical isolate recovered from a patient with cholangitis.
abstract: Several imipenem-susceptible and -resistant Aeromonas veronii biovar sobria isolates with different morphologies and antimicrobial susceptibilities recovered from bile samples of a patient with cholangitis were analysed. These isolates belonged to the same clone and the imipenem-resistant strains showed overexpression of the imiS gene, encoding a chromosomal carbapenemase. These results should make clinicians aware of the possible emergence of multidrug-resistant A. veronii biovar sobria, perhaps as a consequence of previous treatment of a urinary tract infection with amoxicillin plus clavulanic acid.
authors.affiliation: Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-Céspedes
authors.affiliation: Unitat de Microbiologia, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Figueras
authors.affiliation: Unidad de Microbiología, Hospital Royo Villanova, Avda San Gregorio 30, 59915 Zaragoza, Spain.
authors.forename: Carmen
authors.initials: C
authors.lastname: Aspiroz
authors.affiliation: Unidad de Microbiología, Hospital Royo Villanova, Avda San Gregorio 30, 59915 Zaragoza, Spain.
authors.forename: Maria José
authors.initials: MJ
authors.lastname: Aldea
authors.affiliation: Unidad de Microbiología, Hospital Royo Villanova, Avda San Gregorio 30, 59915 Zaragoza, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Toledo
authors.affiliation: Unitat de Microbiologia, Departament de Ciències Mèdiques Bàsiques, Facultat de Medicina i Ciències de la Salut, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Spain.
authors.forename: Anabel
authors.initials: A
authors.lastname: Alperí
authors.affiliation: Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Francesc
authors.initials: F
authors.lastname: Marco
authors.affiliation: Servei de Microbiologia, Centre de Diagnòstic Biomèdic, Hospital Clínic, IDIBAPS, Facultat de Medicina, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain.
authors.forename: Jordi
authors.initials: J
authors.lastname: Vila
mesh_terms: D000333:Aeromonas / Q000145:classification / Q000187:drug effects*; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002761:Cholangitis / Q000382:microbiology*; D024881:Drug Resistance, Bacterial; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D015378:Imipenem