title: Avian Aspergillus fumigatus strains resistant to both itraconazole and voriconazole.
abstract: The in vitro susceptibilities of 59 avian Aspergillus fumigatus strains to amphotericin B, itraconazole, and voriconazole were determined using the standard microdilution broth method (CLSI M38-A2). Four isolates showed acquired resistance to itraconazole and voriconazole, harboring implications for the treatment of aspergillosis in both birds and humans.
authors.affiliation: Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. lies.beernaert@ugent.be
authors.forename: L A
authors.initials: LA
authors.lastname: Beernaert
authors.forename: F
authors.initials: F
authors.lastname: Pasmans
authors.forename: L
authors.initials: L
authors.lastname: Van Waeyenberghe
authors.forename: G M
authors.initials: GM
authors.lastname: Dorrestein
authors.forename: F
authors.initials: F
authors.lastname: Verstappen
authors.forename: F
authors.initials: F
authors.lastname: Vercammen
authors.forename: F
authors.initials: F
authors.lastname: Haesebrouck
authors.forename: A
authors.initials: A
authors.lastname: Martel
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000829:Animals, Domestic / Q000382:microbiology; D000835:Animals, Wild / Q000382:microbiology; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000382:microbiology / Q000662:veterinary*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000302:isolation & purification; D001715:Bird Diseases / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D065819:Voriconazole