In vitro activity of terbinafine associated to amphotericin B, fluvastatin, rifampicin, metronidazole and ibuprofen against Pythium insidiosum.
We evaluated the in vitro activities of terbinafine alone and in combination with amphotericin B, fluvastatin, rifampicin, metronidazole or ibuprofen against 17 clinical isolates of Pythium insidiosum. The assays were based on technique M38-A2, as well as the checkerboard microdilution method. The main synergism observed was by combination of terbinafine plus amphotericin B (41.18%). Antagonisms were observed in combinations of terbinafine with fluvastatin (35.30%) or rifampicin (5.88%).
Cavalheiro
Ayrton S
AS
Departamento de Microbiologia e Parasitologia, Laboratório de Pesquisas Micológicas (LAPEMI), Universidade Federal de Santa Maria (UFSM), Avenida Roraima, 1000, Cidade Universitária, Bairro Camobi, Santa Maria-RS, 97105-900, Brazil.
Zanette
Régis A
RA
Spader
Tatiana B
TB
Lovato
Luciane
L
Azevedo
Maria Isabel
MI
Botton
Sonia
S
Alves
Sydney H
SH
Santurio
Janio M
JM
D000666:Amphotericin B / Q000008:administration & dosage / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology; D000077340:Fluvastatin; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology; D008795:Metronidazole / Q000008:administration & dosage / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000008:administration & dosage / Q000494:pharmacology*; D011775:Pythium / Q000187:drug effects*; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology; D000077291:Terbinafine
D000890:Anti-Infective Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005229:Fatty Acids, Monounsaturated; D007211:Indoles; D009281:Naphthalenes; D008795:Metronidazole; D000077340:Fluvastatin; D000666:Amphotericin B; D000077291:Terbinafine; D012293:Rifampin; D007052:Ibuprofen