title: Fermented barley extract suppresses the development of atopic dermatitis-like skin lesions in NC/Nga mice, probably by inhibiting inflammatory cytokines.
abstract: We have found that fermented barley extract (FBE), prepared from barley shochu residue, alleviates allergic rhinitis in OVA-sensitized mice. In this study, we examined to determine whether FBE suppresses the development of atopic dermatitis (AD)-like skin lesions in NC/Nga mice. The development of AD-like skin lesions in a 5% FBE containing diet group was significantly inhibited, and scratching behavior, one of aggravating factors, was also suppressed. Neither serum immunoglobulin E (IgE) levels nor interleukin (IL)-4 production by spleen cells in the 5% FBE diet group was found to be significantly reduced. On the other hand, interferon-gamma (IFN-gamma) and IL-17 production by spleen cells in the 5% FBE diet group was significantly reduced. Hence it was assumed that FBE alleviates AD-like skin lesions in NC/Nga mice, probably by modulating the cytokine production involved in chronic inflammation, such as IFN-gamma or IL-17.
authors.affiliation: YAEGAKI Bio-Industry, Inc., Himeji, Hyogo, Japan. iguch-tk@yaegaki.co.jp
authors.forename: Takafumi
authors.initials: T
authors.lastname: Iguchi
authors.forename: Ayumi
authors.initials: A
authors.lastname: Kawata
authors.forename: Toshiro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Tapan Kumar
authors.initials: TK
authors.lastname: Mazumder
authors.forename: Soichi
authors.initials: S
authors.lastname: Tanabe
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D016207:Cytokines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D005285:Fermentation; D006241:Haptens / Q000009:adverse effects; D001467:Hordeum / Q000737:chemistry* / Q000378:metabolism*; D007073:Immunoglobulin E / Q000097:blood; D007249:Inflammation / Q000378:metabolism / Q000517:prevention & control; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
chemical_list: D016207:Cytokines; D006241:Haptens; D010936:Plant Extracts; D007073:Immunoglobulin E