Clinical biochemistry of assisted conception.
Assisted reproductive technology has shown rapid advancement since the birth of the first 'test-tube' baby in Oldham, UK, in 1978. Since April 2005, women between the ages of 23 and 39, who meet the described eligibility criteria, are able to get one free in vitro fertilization cycle funded by the National Health Service. Private treatment costs anything from pound4000 to pound8000 for a single cycle of treatment. Almost 15% of the couples in UK are affected by fertility problems and undergo detailed investigations before being offered assisted conception. Assisted reproduction is the collective name for treatments designed to lead to conception by means other than sexual intercourse. These include intrauterine insemination, in vitro fertilization, intracytoplasmic sperm injection and gamete donation. This review is intended to summarize the principles of assisted conception and examine the role of the biochemistry laboratory in: (A) the diagnosis and subsequent management of ovulatory disorders; (B) assessing ovarian reserve before initiating fertility treatment and (C) monitoring fertility treatment. It touches on the screening of potential gamete donors and follow-up of children born after assisted conception. This article was prepared at the invitation of the Clinical Sciences Reviews Committee of the Association of Clinical Biochemistry.
Srivastava
Rajeev
R
Department of Biochemical Medicine, Ninewells Hospital and Medical School, Dundee, UK. rajeev.srivastava@nhs.net
Kay
Vanessa
V
D005260:Female; D006801:Humans; D007246:Infertility / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D008297:Male; D027724:Reproductive Techniques, Assisted; D006113:United Kingdom