An oxepinoflavone from Artocarpus elasticus with cytotoxic activity against P-388 cells.
A new oxepinoflavone, artoindonesianin E1 (1), was isolated from the wood of Artocarpus elasticus, along with four known prenylated flavones: artocarpin (2), cycloartocarpin (3), cudraflavones A (4) and C (5). The structure of the new compound was identified by spectroscopic methods. Upon cytotoxic evaluation against murine leukemia P-388 cells, the new compound showed IC(50) 5.0 microg/mL.
Musthapa
Iqbal
I
Institut Teknologi Bandung, Natural Products Research Group, Faculty of Mathematics and Natural Sciences, Jalan Ganesha 10, Bandung 40132, Indonesia.
Juliawaty
Lia D
LD
Syah
Yana M
YM
Hakim
Euis H
EH
Latip
Jalifah
J
Ghisalberti
Emilio L
EL
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D010082:Oxepins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D047309:Flavones; D005419:Flavonoids; D010082:Oxepins; C540203:artoindonesianin E1