title: High dose of red wine elicits enhanced inhibition of fibrinolysis.
abstract: METHODS
  The purpose of this randomized controlled cross-over study was to determine the acute effects of high doses of alcoholic beverages on circulating markers related to atherosclerosis and fibrinolysis.
  
  
  METHODS
  Twenty-two healthy men consumed a high dose (8.1+/-0.9 dl) of alcohol-containing red wine and dealcoholized red wine, and an equal ethanol dose of cognac (2.4+/-0.3 dl). Blood samples were taken before and shortly after interventions.
  
  
  RESULTS
  Red wine, unlike dealcoholized red wine and cognac, increased tissue plasminogen activator inhibitor-1 levels significantly, indicating an acute inhibition of fibrinolysis after a high dose.
  
  
  CONCLUSIONS
  Findings may explain the increased risk of cardiovascular mortality among binge drinkers.
authors.affiliation: Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. tuoski@utu.fi
authors.forename: Tuomas O
authors.initials: TO
authors.lastname: Kiviniemi
authors.forename: Antti
authors.initials: A
authors.lastname: Saraste
authors.forename: Terho
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: Jyri O
authors.initials: JO
authors.lastname: Toikka
authors.forename: Markku
authors.initials: M
authors.lastname: Saraste
authors.forename: Olli T
authors.initials: OT
authors.lastname: Raitakari
authors.forename: Jussi P
authors.initials: JP
authors.lastname: Pärkkä
authors.forename: Jaakko J
authors.initials: JJ
authors.lastname: Hartiala
authors.forename: Jorma
authors.initials: J
authors.lastname: Viikari
authors.forename: Juha W
authors.initials: JW
authors.lastname: Koskenvuo
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects* / Q000097:blood; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology*; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology*; D018592:Cross-Over Studies; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D008297:Male; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D014920:Wine / Q000009:adverse effects*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D000431:Ethanol