title: Epicardial control of myocardial proliferation and morphogenesis.
abstract: The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.
authors.affiliation: Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St., IGM240, Los Angeles, CA 90033, USA. sucov@usc.edu
authors.forename: Henry M
authors.initials: HM
authors.lastname: Sucov
authors.forename: Ying
authors.initials: Y
authors.lastname: Gu
authors.forename: Simmy
authors.initials: S
authors.lastname: Thomas
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Mohammad
authors.initials: M
authors.lastname: Pashmforoush
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D049109:Cell Proliferation; D003331:Coronary Vessels / Q000196:embryology; D006133:Growth Substances; D006321:Heart / Q000196:embryology*; D051379:Mice; D009206:Myocardium; D032383:Myocytes, Cardiac / Q000502:physiology; D010496:Pericardium / Q000196:embryology*; D015398:Signal Transduction
chemical_list: D006133:Growth Substances