RNA localization and polarity: from A(PC) to Z(BP).
Cell polarization relies on the asymmetric organization of cellular structures and activities, and is fundamentally important both during development and for the proper function of most somatic cells. Asymmetries in the distribution and activity of proteins can be achieved through localization of RNA molecules that usually give rise to proteins at specific subcellular sites. It is increasingly appreciated that this is a widely used mechanism affecting protein function at multiple levels. The description of a new RNA localization pathway involving the tumor-suppressor protein APC raises questions regarding coordination between distinct localization pathways and their effects on protein function and cell polarity.
Mili
Stavroula
S
Department of Microbiology, Center for Cell Signaling, University of Virginia, HSC, Charlottesville, 22908-0577, USA.
Macara
Ian G
IG
D025601:Adenomatous Polyposis Coli Protein / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D006801:Humans; D021381:Protein Transport; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction
D025601:Adenomatous Polyposis Coli Protein; C406144:IGF2BP1 protein, human; D016601:RNA-Binding Proteins; D012313:RNA