title: [A case of lymphocytic interstitial pneumonia complicated with primary Sjögren's syndrome followed by chest CT scanning for thirteen years].
abstract: We encountered a rare case of lymphocytic interstitial pneumonia (LIP) complicated with primary Sjögren's syndrome (SjS), followed by chest CT scanning for a long period of time. A 54-year-old man with hemoptysis was admitted to our hospital in December, 2001. A diagnosis of SjS was made based on elevation of anti-SS-B/La antibody titer in serum in combination with diagnosis of keratoconjunctivitis sicca and xerostomia on a Schirmer test and a lip biopsy, respectively. Subsequent histopathological diagnosis by open lung biopsy showed LIP. Chest CT in September, 1995 at previous hospital revealed ground-glassed opacity (GGO), small nodules, thickened bronchovascular bundles and cyst formation in lungs. Chest CT was performed every year until 2008, when remarkable progression from thickened bronchovascular bundles accompanied by nodular opacities to an air-space consolidation in the right lower lobe was observed. Also, appearance of cyst formation in the right middle lobe, nodular lesions and GGO in the left lower lobe were noticed. Although the nodular opacities and GGO improved after an administration of corticosteroid (PSL 0.5 mg/kg/day), little improvement in the consolidations and cyst formation was demonstrated. In conclusion, it was suggested that differences among CT findings of LIP may be important for evaluating of efficacy of treatment by steroid agents for LIP associated with SjS.
authors.affiliation: Respiratory Center, Yokohama City University Medical Center.
authors.forename: Jun
authors.initials: J
authors.lastname: Tsukiji
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
authors.forename: Masako
authors.initials: M
authors.lastname: Inoue
authors.forename: Toshinori
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Shiobara
authors.forename: Masaru
authors.initials: M
authors.lastname: Ito
authors.forename: Harumi
authors.initials: H
authors.lastname: Koizumi
authors.forename: Akinori
authors.initials: A
authors.lastname: Nozawa
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Shuji
authors.initials: S
authors.lastname: Murakami
authors.forename: Koji
authors.initials: K
authors.lastname: Tomaru
authors.forename: Hideaki
authors.initials: H
authors.lastname: Oka
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Hideto
authors.initials: H
authors.lastname: Goto
authors.forename: Makoto
authors.initials: M
authors.lastname: Kudo
authors.forename: Satoshi
authors.initials: S
authors.lastname: Inoue
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyazawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Watanuki
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Ishigatsubo
mesh_terms: D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications*; D014057:Tomography, X-Ray Computed