Profile of autoantibodies in Jaccoud's arthropathy.
OBJECTIVE
To compare the frequency of different autoantibodies in a group of patients with Jaccoud's arthropathy (JA) secondary to systemic lupus erythematosus (SLE) with those without JA.


METHODS
A group of SLE patients with JA was compared with another group of SLE patients without this complication, matched by age and gender, regarding the presence of autoantibodies. Antibodies to cyclical citrullinated peptides (anti-CCP) and to mutated citrullinated vimentin (anti-MCV) as well as anti-SSA/Ro, anti-SSB/La, anti-Sm and anti-RNP and anticardiolipin (aCL) antibodies were searched by ELISA, using commercial kits. Rheumatoid factor was determined by nephelometry and antinuclear and anti-dsDNA antibodies by IIF.


RESULTS
Forty-eight individuals were included in the study, being 24 patients with JA and 24 without JA, matched by gender and age. The frequency of anti-CCP antibodies in the whole population was 12.5% (6 cases), with no difference between the 2 groups. Anti-MCV antibodies were detected in 10.4% (5 cases), being found only in those with JA (p=0.05). There was no association between the presence of JA and aCL, anti-Sm, anti-RNP and anti-SSB/La antibodies. On the other hand, a statistically significant association between the presence of anti-dsDNA antibodies and JA was observed (p=0.04) as well as a marginal association with a decrease in serum levels of C3 (p=0.06).


CONCLUSIONS
In the present study, there was an association between the presence of JA and anti-dsDNA antibodies, and anti-MCV antibodies were found only in those SLE patients with JA. Whether these antibodies have an etiopathogenic role in JA is entirely unknown.
Galvão
Verena
V
Fundação Bahiana para o Desenvolvimento das Ciências, Salvador, Bahia, Brazil.
Atta
Ajax Mercês
AM
Sousa Atta
Maria Luiza
ML
Motta
Marina
M
Dourado
Stella
S
Grimaldi
Lara
L
Oliveira e Silva
Natália
N
Silva de Oliveira
Isabela
I
Santiago
Mittermayer B
MB
D000328:Adult; D001168:Arthritis / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000276:immunology; D002956:Citrulline / Q000378:metabolism; D004247:DNA / Q000276:immunology*; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000276:immunology / Q000378:metabolism; D012217:Rheumatoid Factor / Q000276:immunology; D012261:Ribonucleoproteins / Q000276:immunology; D014746:Vimentin / Q000276:immunology* / Q000378:metabolism; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D001323:Autoantibodies; D001324:Autoantigens; D002956:Citrulline; D004247:DNA; D010455:Peptides; D012217:Rheumatoid Factor; D012261:Ribonucleoproteins; D014746:Vimentin; D000097585:SS-B Antigen; D000099207:SS-A Antigen