Intrauterine insemination with or without mild ovarian stimulation in couples with male subfertility due to oligo/astheno- and/or teratozoospermia or antisperm antibodies: a prospective cross-over trial.
Seventy-three couples with male subfertility, which was due to oligo/astheno- and/or teratozoospermia (n = 63) or antisperm antibodies (n = 10), were randomly assigned to sequential timed natural intercourse, intrauterine insemination (IUI) and IUI + mild ovarian hyperstimulation. From the analysis of 384 observed cycles, IUI was shown to be effective in oligo/asthenozoospermia without severe teratozoospermia, when it was associated with moderate multifollicular induction, and in male immunologic subfertility, IUI was highly effective in nonstimulated cycles also.
Francavilla
Felice
F
Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy. Electronic address: francavi@cc.univaq.it.
Sciarretta
Filomena
F
Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.
Sorgentone
Sara
S
Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.
Necozione
Stefano
S
Epidemiology, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.
Santucci
Riccardo
R
Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.
Barbonetti
Arcangelo
A
Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.
Francavilla
Sandro
S
Andrologic Unit, Department of Internal Medicine, University of L'Aquila, L'Aquila, Italy.
D000888:Antibodies, Anti-Idiotypic / Q000009:adverse effects*; D053627:Asthenozoospermia / Q000150:complications*; D002996:Clomiphene / Q000494:pharmacology; D003075:Coitus / Q000502:physiology; D018592:Cross-Over Studies; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology; D006801:Humans; D007248:Infertility, Male / Q000209:etiology* / Q000628:therapy*; D007315:Insemination, Artificial / Q000379:methods*; D050498:Live Birth; D008297:Male; D008596:Menotropins / Q000494:pharmacology; D009845:Oligospermia / Q000150:complications*; D010053:Ovary / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D013094:Spermatozoa / Q000276:immunology*; D016896:Treatment Outcome
D000888:Antibodies, Anti-Idiotypic; D005300:Fertility Agents, Female; D002996:Clomiphene; D008596:Menotropins