title: Brazilian natural medicines. III. structures of triterpene oligoglycosides and lipase inhibitors from mate, leaves of ilex paraguariensis.
abstract: The methanolic extract from the leaves of Ilex paraguariensis (Aquifoliaceae) was found to show an inhibitory activity on porcine pancreatic lipase. From the methanolic extract, three new triterpene oligoglycosides, mateglycosides A, B, and C, were isolated together with 18 known compounds. The chemical structures of new oligoglycosides were elucidated on the basis of chemical and physicochemical evidence. Several constituents showed inhibitory activities on pancreatic lipase.
authors.affiliation: Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sugimoto
authors.forename: Seikou
authors.initials: S
authors.lastname: Nakamura
authors.forename: Sachiyo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Chihiro
authors.initials: C
authors.lastname: Yamashita
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Oda
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsuda
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
mesh_terms: D000818:Animals; D001938:Brazil; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry*; D030019:Ilex paraguariensis / Q000737:chemistry*; D008049:Lipase / Q000037:antagonists & inhibitors*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry; D013552:Swine; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes; D008049:Lipase