Interleukin-7 receptor-alpha gene polymorphisms in bone marrow transplant recipients.
Graft-versus-host disease is the main complication after hematopoietic stem cells transplantation (HSCT). Non-HLA genotypes, such as cytokines, have been investigated for their potential roles in the occurrence and severity of GVHD as well as for their contribution to overall transplant-related mortality and survival. IL-7 which is secreted by bone marrow stromal cells plays an important role in the development and survival of T cells. Its effect is mediated via interleukin 7 receptor (IL7R). This study investigates the possible links between IL-7alphaR single nucleotide polymorphisms (+510 C/T, +1237 A/G, +2087 T/C and +3110A/G) and transplant outcomes among 116 recipients of HSCT. Genotypes were determined using polymerase chain reaction-sequence-specific primers. No significant differences were observed between the genotypic distributions of IL-7alphaR polymorphisms and incidence of acute or chronic graft versus host disease. Additional studies with larger sample are necessary to further define the influence of IL-7alphaR on the immune response after bone marrow transplantation.
Azarpira
Negar
N
Organ Transplant Research Center, Shiraz University of Medical Sciences, Zand Street, Nemazi Hospital, Shiraz, Iran. negarazarpira@yahoo.com
Dehghani
Mehdi
M
Aghdaie
Mahdokth H
MH
Darai
Masumeh
M
D000328:Adult; D016026:Bone Marrow Transplantation; D003710:Demography; D005260:Female; D005838:Genotype; D006086:Graft vs Host Disease / Q000235:genetics; D006801:Humans; D053699:Interleukin-7 Receptor alpha Subunit / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D053699:Interleukin-7 Receptor alpha Subunit