title: RNA localization and polarity: from A(PC) to Z(BP).
abstract: Cell polarization relies on the asymmetric organization of cellular structures and activities, and is fundamentally important both during development and for the proper function of most somatic cells. Asymmetries in the distribution and activity of proteins can be achieved through localization of RNA molecules that usually give rise to proteins at specific subcellular sites. It is increasingly appreciated that this is a widely used mechanism affecting protein function at multiple levels. The description of a new RNA localization pathway involving the tumor-suppressor protein APC raises questions regarding coordination between distinct localization pathways and their effects on protein function and cell polarity.
authors.affiliation: Department of Microbiology, Center for Cell Signaling, University of Virginia, HSC, Charlottesville, 22908-0577, USA.
authors.forename: Stavroula
authors.initials: S
authors.lastname: Mili
authors.forename: Ian G
authors.initials: IG
authors.lastname: Macara
mesh_terms: D025601:Adenomatous Polyposis Coli Protein / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement; D016764:Cell Polarity; D006801:Humans; D021381:Protein Transport; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D025601:Adenomatous Polyposis Coli Protein; C406144:IGF2BP1 protein, human; D016601:RNA-Binding Proteins; D012313:RNA