[Analysis of the chromosomal abnormality in 5774 patients with clinical reproductive abnormality and 32 new karyotypes].
To study the relationship between chromosomal abnormality and clinical ending events of reproductive abnormality, G-banding and karyotype analyses were carried out by using chromosome preparations from peripheral blood lymphocytes. Out of 5 774 cases with reproductive abnormality, 550 individuals had chromosomal abnormalities. Among them, 255 cases (46.36%) were trisomy, 91 cases (16.55%) were reciprocal translocation, 85 cases (15.45%) were chromosomal inversion, 81 cases (14.73%) were deletions, 21 cases (3.82%) were Robertsonian translocation, 7 cases (1.27%) were short arm increment, 6 cases (1.09%) were Y chromosome increment and 4 cases (0.73%) were abnormal satellites. Thirty-two cases with novel chromosomal abnormality karyotypes in them, being complicated by miscarriage, sterility, and congenital malformation, were firstly reported. The results suggested that chromosomal abnormality could be the one of main factors related to the bad reproductive ending events.
Qin
Jing
J
Guangxi Zhuang Autonomous Region Women and Children Care Hospital, Nanning 530003, China.
Zheng
Chen-Guang
CG
DU
Juan
J
Chen
Ke
K
Tian
Xiao-Xian
XX
Xiang
Lei
L
Sun
Liang
L
Yang
Ze
Z
D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D000013:Congenital Abnormalities; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D014178:Translocation, Genetic; D014314:Trisomy