Stabilizing guanosine-sterol ion channels with a carbamate to urea modification in the linker.
The use of a bis-urea lithocholamide linker within a guanosine-sterol dimer resulted in formation of large and stable ion channels. The channels were longer-lived than those formed by the corresponding bis-carbamate.
Ma
Ling
L
Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742, USA.
Harrell
William A
WA
Davis
Jeffery T
JT
D002219:Carbamates / Q000737:chemistry*; D006151:Guanosine / Q000737:chemistry*; D007473:Ion Channels / Q000138:chemical synthesis* / Q000737:chemistry; D008095:Lithocholic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D015394:Molecular Structure; D013261:Sterols / Q000737:chemistry*; D014508:Urea / Q000737:chemistry*
D002219:Carbamates; D007473:Ion Channels; D013261:Sterols; C408481:lithocholamide; D006151:Guanosine; D008095:Lithocholic Acid; D014508:Urea