title: Extended prone position ventilation in severe acute respiratory distress syndrome: a pilot feasibility study.
abstract: OBJECTIVE
  The aim of the study was to evaluate the safety of extended prone position ventilation (PPV) and its impact on respiratory function in patients with severe acute respiratory distress syndrome (ARDS).
  
  
  METHODS
  This was a prospective interventional study.
  
  
  METHODS
  Patients were recruited from a mixed medical-surgical intensive care unit in a university hospital.
  
  
  METHODS
  Fifteen consecutive patients with severe ARDS, previously unresponsive to positive end-expiratory pressure adjustment, were treated with PPV.
  
  
  METHODS
  Prone position ventilation for 48 hours or until the oxygenation index was 10 or less (extended PPV).
  
  
  RESULTS
  The elapsed time from the initiation of mechanical ventilation to pronation was 35 +/- 11 hours. Prone position ventilation was continuously maintained for 55 +/- 7 hours. Two patients developed grade II pressure ulcers of small extent. None of the patients experienced life-threatening complications or hemodynamic instability during the procedure. The patients showed a statistically significant improvement in Pao(2)/Fio(2) (92 +/- 12 vs 227 +/- 43, P < .0001) and oxygenation index (22 +/- 5 vs 8 +/- 2, P < .0001), reduction of PaCo(2) (54 +/- 9 vs 39 +/- 4, P < .0001) and plateau pressure (32 +/- 2 vs 27 +/- 3, P < .0001), and increment of the static compliance (21 +/- 3 vs 37 +/- 6, P < .0001) with extended PPV. All the parameters continued to improve significantly while they remained in prone position and did not change upon returning the patients to the supine position.
  
  
  CONCLUSIONS
  The results obtained suggest that extended PPV is safe and effective in patients with severe ARDS when it is carried out by a trained staff and within an established protocol. Extended PPV is emerging as an effective therapy in the rescue of patients from severe ARDS.
authors.affiliation: Critical Patient Unit, Department of Medicine, University of Chile Clinical Hospital, Santiago Norte, Chile. caromero@redclinicauchile.cl
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Romero
authors.forename: Rodrigo A
authors.initials: RA
authors.lastname: Cornejo
authors.forename: L Ricardo
authors.initials: LR
authors.lastname: Gálvez
authors.forename: Osvaldo P
authors.initials: OP
authors.lastname: Llanos
authors.forename: Eduardo A
authors.initials: EA
authors.lastname: Tobar
authors.forename: M Angélika
authors.initials: MA
authors.lastname: Berasaín
authors.forename: Daniel H
authors.initials: DH
authors.lastname: Arellano
authors.forename: Jorge F
authors.initials: JF
authors.lastname: Larrondo
authors.forename: José S
authors.initials: JS
authors.lastname: Castro
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D002677:Chile; D003422:Critical Care / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008170:Lung Compliance; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D003668:Pressure Ulcer / Q000209:etiology; D016684:Prone Position / Q000502:physiology; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000009:adverse effects / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D015656:Respiratory Mechanics / Q000502:physiology; D016683:Supine Position / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult