Colloidal mesoporous silica nanoparticles with protoporphyrin IX encapsulated for photodynamic therapy.
Protoporphyrin IX (PpIX)-encapsulated mesoporous silica nanoparticles were synthesized, characterized, and utilized for photodynamic therapy (PDT) of cancer. Silica encapsulation is relatively transparent for activated light and can protect the PpIX against denaturation induced by the extreme bioenvironment. The mesoporous silica can also ensure that the encapsulated PpIX can be well-contacted with oxygen, stimulated, and released. PpIX-encapsulated colloidal mesoporous silica nanoparticles were uptaken by tumor cells in vitro, and the effect of photon-induced toxicity was demonstrated after comparison with some control experiments. The surface of PpIX-encapsulated silica nanoparticles can be grafted with appropriate functionalized groups and conjugated with certain biomolecules for specific targeting.
Qian
Jun
J
Zhejiang University, Joint Research Center of Photonics of the Royal Institute of Technology (Sweden) and Zhejiang University, Centre for Optical and Electromagnetic Research, Zijingang Campus, Hangzhou 310058, China.
Gharibi
Arash
A
He
Sailing
S
D002214:Capsules; D002470:Cell Survival / Q000187:drug effects*; D003102:Colloids; D004337:Drug Carriers / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D050997:Nanomedicine / Q000379:methods*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000737:chemistry; D016062:Porosity; D011524:Protoporphyrins / Q000008:administration & dosage* / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
D002214:Capsules; D003102:Colloids; D004337:Drug Carriers; D017319:Photosensitizing Agents; D011524:Protoporphyrins; D012822:Silicon Dioxide; C028025:protoporphyrin IX