title: [Research progress on relationship between subchondral bone and cartilage degeneration in osteoarthritis].
abstract: OBJECTIVE
  To review the recent research progress on relationship between subchondral bone and cartilage degeneration in osteoarthritis (OA), and to predict future research directions.
  
  
  METHODS
  Recent literatures about the pathological changes of subchondral bone in OA were reviewed and analyzed in terms of biomechanics, bone remodeling and biological factors.
  
  
  RESULTS
  Subchondral bone sclerosis or softening was the result of osteoarthritis and also closely related to the occurrence and development of OA. Inhibiting the bone metabolism of subchondral bone could slow the degeneration of articular cartilage.
  
  
  CONCLUSIONS
  For the treatment of OA, it is necessary to pay close attention to cartilage changes and the prevention of subchondral bone degeneration.
authors.affiliation: Department of Orthopaedics, Affiliated Hospital of North China Coal Medical College, Tangshan Hebei, 063000, P.R. China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Li
authors.forename: Liu
authors.initials: L
authors.lastname: Zhang
mesh_terms: D001696:Biomechanical Phenomena; D015519:Bone Density; D016723:Bone Remodeling; D002358:Cartilage, Articular / Q000378:metabolism / Q000473:pathology*; D010003:Osteoarthritis / Q000378:metabolism / Q000473:pathology*