First total synthesis of the whole series of the antiostatins A and B.
The first synthesis of the whole antiostatin family is described by using an iron-mediated carbazole synthesis, regioselective nitration at C-4 and establishing 5-isobutyl-1-nitrobiuret as a reagent for introduction of the antiostatin B side chain at C-4.
Knott
Kerstin E
KE
Department Chemie, Technische Universität Dresden, Bergstrasse 66, 01069, Dresden, Germany.
Auschill
Stefan
S
Jäger
Anne
A
Knölker
Hans-Joachim
HJ
D002227:Carbazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007501:Iron / Q000737:chemistry; D013237:Stereoisomerism
D002227:Carbazoles; C540617:antiostatin A1; C540618:antiostatin B2; C041514:carbazole; D007501:Iron