[Effect of atractylodes rhizome oil and other volatile oils on percutaneous absorption of baicalin].
OBJECTIVE
To study the effects of atractylodes rhizome oil, patchouli oil, angelica volatile oil on the transdermal delivery of baicalin.


METHODS
The modified Valia-Chien diffusion cells was used. With saline isotonic solution as receptor fluid and different concentration of atractylodes rhizome oil, patchouli oil, angelica volatile oil as enhancers, the cumulative amount of baicalin penatrating through the skin was determined in vitro.


RESULTS
All the three volatile oils improved the skin penetration of baicalin, and the effect of atractylodes rhizome oil was the best.


CONCLUSIONS
Atractylodes rhizome oil is an effective enhancer for percutaneous penetration of baicalin.
Luo
Mao-Fu
MF
Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China.
Shen
Qi
Q
Zhang
Tong
T
Xu
Yue-Hong
YH
D000279:Administration, Cutaneous; D000818:Animals; D031174:Atractylodes / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000493:pharmacokinetics*; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D010539:Permeability / Q000187:drug effects; D010938:Plant Oils / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D031364:Scutellaria baicalensis / Q000737:chemistry*; D012867:Skin / Q000187:drug effects / Q000378:metabolism; D012869:Skin Absorption / Q000187:drug effects*; D013056:Spectrophotometry, Ultraviolet
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009822:Oils, Volatile; D010938:Plant Oils; C038044:baicalin