SpliceAid: a database of experimental RNA target motifs bound by splicing proteins in humans.
The correct post-transcriptional RNA processing is finely regulated by RNA-binding proteins. Unfortunately, there is little experimental information on target RNA sequences of RNA-binding proteins and moreover such experimentally derived target sequences are annotated in a compact form by the score matrices that overestimate the number of possible recognized sequences. We carried out an exhaustive hand curated literature search to create a database, SpliceAid, collecting all the experimentally assessed target RNA sequences that are bound by splicing proteins in humans. We built a web resource, database driven, to easy query SpliceAid and give back the results by an accurate and dynamic graphic representation.


BACKGROUND
SpliceAid database is freely accessible at http://www.introni.it/splicing.html.
Piva
Francesco
F
Institute of Biology and Genetics, Polytechnic University of Marche, 60131, Ancona, Italy. f.piva@univpm.it
Giulietti
Matteo
M
Nocchi
Linda
L
Principato
Giovanni
G
D001665:Binding Sites; D030561:Databases, Nucleic Acid; D006801:Humans; D020407:Internet; D012313:RNA / Q000737:chemistry*; D012326:RNA Splicing; D016601:RNA-Binding Proteins / Q000737:chemistry*
D016601:RNA-Binding Proteins; D012313:RNA