[The effects of carbogen inhalation on microvascular within lateral wall of cochlear following acute acoustic trauma].
OBJECTIVE
To explore the influence of carbogen on lateral wall microvascular of cochlear after acute acoustic trauma.


METHODS
Forty guinea pigs were divided into 4 groups: group A (noise damage), group B (carbogen inhalation), group C (noise damage + carbogen inhalation), and the control group without any treatment. The diameter of the column of RBCs (RBC column diameter, RBCCD), blood flow velocity (BFV) and blood flow states(BFS) in microvasculature were measured and described under microscope.


RESULTS
The microvascular in group A demonstrated a blood flow in contrary direction, granuliform flow, and granular slow flow. The erythrocytes aggregated in the microvascular of the cochlea. The RBCCD decreased 12.1% compared with the control group (P < 0.05). The blood flow in group B showed a laminar flow or laminar granular flow, and the RBCCD increased 20.7% compared with the control group. The blood condition in group C was the same as the control group-laminar granular blood flow; the blood flow with contrary direction was less than group A, and the RBCCD was 17.4% lager than that of group A.


CONCLUSIONS
Carbogen can dilate the RBCCD and increase the BFV in stria vascular. So carbogen can alleviate the harm from noise.
Zhao
Jing
J
Department of Otolaryngology, Beijing Nary General Hospital, Beijing 100037, China. zhaoj_ent2008@126.com
Sun
Jianjun
J
Kong
Weijia
W
D000818:Animals; D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000627:therapeutic use*; D003051:Cochlea / Q000098:blood supply*; D004912:Erythrocytes / Q000166:cytology; D005260:Female; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000473:pathology / Q000628:therapy*; D008297:Male; D008833:Microcirculation; D010100:Oxygen / Q000008:administration & dosage / Q000627:therapeutic use*
D002245:Carbon Dioxide; C011700:carbogen; D010100:Oxygen