[Evidence-based pharmacological interventions in intensive therapy].
Very few randomised controlled trials (RCTs) conducted in intensive care units and using mortality as their primary outcome have shown a beneficial effect of pharmacological intervention on survival. Other types of evidence than the RCT should therefore be considered. Observational studies (clinical epidemiological studies) based on public registers and clinical databases have shown good agreement with the results from RCTs. The populations of Denmark and the remaining Scandinavian countries are well-registered and as such an ideal base for clinical, epidemiological studies supplementing the RCTs.
Tønnesen
Else Kirstine
EK
Anaestesiologisk-intensiv Afdeling, Arhus Universitetshospital, DK-8000 Arhus C. elsetoen@rm.dk
Toft
Palle
P
D003422:Critical Care / Q000379:methods; D016638:Critical Illness / Q000401:mortality*; D019317:Evidence-Based Medicine; D005938:Glucocorticoids / Q000008:administration & dosage; D017052:Hospital Mortality; D006801:Humans; D007328:Insulin / Q000008:administration & dosage; D019370:Observation / Q000379:methods; D017063:Outcome Assessment, Health Care; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011486:Protein C / Q000378:metabolism; D016032:Randomized Controlled Trials as Topic; D011994:Recombinant Proteins / Q000008:administration & dosage; D012772:Shock, Septic / Q000188:drug therapy / Q000401:mortality; D015996:Survival Rate; D016896:Treatment Outcome
D005938:Glucocorticoids; D007328:Insulin; D004364:Pharmaceutical Preparations; D011486:Protein C; D011994:Recombinant Proteins