title: Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation.
authors.forename: Kensaku
authors.initials: K
authors.lastname: Kasuga
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ohno
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Ishihara
authors.forename: Akinori
authors.initials: A
authors.lastname: Miyashita
authors.forename: Ryozo
authors.initials: R
authors.lastname: Kuwano
authors.forename: Osamu
authors.initials: O
authors.lastname: Onodera
authors.forename: Masatoyo
authors.initials: M
authors.lastname: Nishizawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ikeuchi
mesh_terms: D000328:Adult; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D001284:Atrophy / Q000209:etiology / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D004252:DNA Mutational Analysis; D003866:Depressive Disorder / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006212:Hallucinations / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D020734:Parkinsonian Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D010375:Pedigree; D053764:Presenilin-1 / Q000235:genetics*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: C508853:PSEN1 protein, human; D053764:Presenilin-1