title: Pathophysiological implications of focal cortical dysplasia of end folium for hippocampal sclerosis.
abstract: Dual pathology is a well-known cause of temporal lobe epilepsy (TLE), but TLE associated with dual pathology within the hippocampus has rarely been reported. We describe a patient with medically refractory TLE due to a focal cortical dysplasia of the end folium of the left hippocampus (i.e. CA4) and left hippocampal sclerosis (HS) that was successfully treated with left anterior temporal lobectomy and speculate on the interaction between end folium sclerosis and HS.
authors.affiliation: Department of Clinical Neurological Sciences, University of Western Ontario, London, Ontario, Canada. smirsat2@uwo.ca
authors.forename: Seyed M
authors.initials: SM
authors.lastname: Mirsattari
authors.forename: David A
authors.initials: DA
authors.lastname: Steven
authors.forename: Julia
authors.initials: J
authors.lastname: Keith
authors.forename: Robert R
authors.initials: RR
authors.lastname: Hammond
mesh_terms: D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000473:pathology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D054220:Malformations of Cortical Development / Q000150:complications*; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D012598:Sclerosis / Q000209:etiology; D055815:Young Adult
chemical_list: D010751:Phosphopyruvate Hydratase