3-Hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylates--a new class of HIV-1 integrase inhibitors.
A new class of inhibitors of HIV-1 integrase has been optimized to provide selective and highly efficient strand transfer inhibition.
Donghi
Monica
M
Department of Medicinal Chemistry, IRBM, Merck Research Laboratories Rome, Via Pontina km 30,600, 00040 Pomezia, Rome, Italy. monica_donghi@merck.com
Kinzel
Olaf D
OD
Summa
Vincenzo
V
D000818:Animals; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D015497:HIV-1 / Q000187:drug effects; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D013329:Structure-Activity Relationship
D019428:HIV Integrase Inhibitors; D011743:Pyrimidines; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1