Coexpression of the mutated BRCA1 mRNA and p53 mRNA and its association in Chinese prostate cancer.
The mutations of BRCA1 and p53 genes have been simultaneously characterized in many tumors. However, their coexpression and associations have not been investigated quantitatively in prostate cancer. In the present study, the expressions of the mutated BRCA1 mRNA and p53 mRNA were examined in 48 Chinese prostate cancer cases and 10 corresponding adjacent benign tissues with in situ hybridization. The 5-year survival rates of the corresponding patients after operation were investigated. The results showed that the positive expressions of the mutated BCRA1 mRNA and p53 mRNA are involved in prostate cancer (P < 0.05). Moreover, there is a closed negative association between the expressions of the mutated BRCA1 gene and p53 gene in the mRNA level with the progression, angiogenesis, metastasis, and survival rate of prostate cancer. Their coexpression and negative association suggest that the two altered tumor suppressor genes might interact functionally in prostate cancer to provide a potential signal determining a prognosis of the tumor metastasis and survival rate. Further work will be done to elucidate the interaction mechanisms in prostate cancer.
Ding
Guo-Fang
GF
School of Medicine, Zhejiang Ocean University, Zhoushan, PR China.
Xu
Yin-Feng
YF
Yang
Zui-Su
ZS
Ding
Yi-Lin
YL
Fang
Hai-Fei
HF
Zhao
Hong-Ping
HP
D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D019313:BRCA1 Protein / Q000235:genetics*; D002681:China; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009367:Neoplasm Staging; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000208:ethnology / Q000235:genetics* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
D019313:BRCA1 Protein; D012333:RNA, Messenger; D016159:Tumor Suppressor Protein p53