title: The stability of biapenem and structural identification of impurities in aqueous solution.
abstract: The stability of biapenem in aqueous solution was investigated. Forced degradation of biapenem was carried out under different concentrations, pH values and temperatures. The degradation products were determined by reverse-phase HPLC and identified by LC-MS/MS. One dimeric impurity was obtained by reverse-phase preparative HPLC and characterized by LC-MS/MS and NMR. A possible degradation mechanism has been presented.
authors.affiliation: Department of Pharmacy, Jiangsu Simcere Pharmaceutical R&D Co Ltd, Nanjing, PR China. xiaming1217@163.com
authors.forename: Ming
authors.initials: M
authors.lastname: Xia
authors.forename: Tai-Jun
authors.initials: TJ
authors.lastname: Hang
authors.forename: Fei
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Li
authors.forename: Xiang-Yang
authors.initials: XY
authors.lastname: Xu
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004340:Drug Contamination; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012996:Solutions; D013696:Temperature; D013845:Thienamycins / Q000032:analysis*; D014867:Water
chemical_list: D000890:Anti-Infective Agents; D012996:Solutions; D013845:Thienamycins; D014867:Water; C065257:biapenem