Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats.
Baccharis dracunculifolia DC (Asteraceae), a native plant from Brazil, commonly known as 'Alecrimdo-campo' is widely used in folk medicine to treat inflammation, hepatic disorders and stomach ulcers, and it is the most important botanical source of Southeastern Brazilian propolis, known as green propolis. Its essential oil is composed of non-oxygenated and oxygenated terpenes. In this work, the effects of the essential oil obtained from the aerial parts of B. dracunculifolia on gastric ulcers were evaluated. The antiulcer assays were undertaken using the following protocols in rats: nonsteroidal antiinflammatory drug (NSAID)-induced ulcer, ethanol-induced ulcer, stress-induced ulcer, and determination of gastric secretion using ligated pylorus. The treatment in the doses of 50, 250 and 500 mg/kg of B. dracunculifolia essential oil significantly diminished the lesion index, the total lesion area and the percentage of lesions in comparison with both positive and negative control groups. With regard to the model of gastric secretion a reduction of gastric juice volume and total acidity was observed, as well as an increase in the gastric pH. No sign of toxicity was observed in the acute toxicity study. Considering the results, it is suggested that the essential oil of B. dracunculifolia could probably be a good therapeutic agent for the development of new phytotherapeutic medicine for the treatment of gastric ulcer.
Massignani
Juliane Jose
JJ
Núcleo de Ciência e Tecnologia, Area de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Videira, SC, Brazil.
Lemos
Marivane
M
Maistro
Edson Luis
EL
Schaphauser
Hamilton Pedro
HP
Jorge
Renata Fabiane
RF
Sousa
João Paulo Barreto
JP
Bastos
Jairo Kennup
JK
de Andrade
Sérgio Faloni
SF
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D031175:Baccharis / Q000737:chemistry*; D004195:Disease Models, Animal; D000431:Ethanol; D005750:Gastric Juice / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D009822:Oils, Volatile / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology; D013315:Stress, Psychological
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D009822:Oils, Volatile; D010936:Plant Extracts; D000431:Ethanol