title: A case study of an emerging visual artist with frontotemporal lobar degeneration and amyotrophic lateral sclerosis.
abstract: Patients presenting with left-sided FTLD syndromes sometimes develop a new preoccupation with art, greater attention to visual stimuli, and increased visual creativity. We describe the case of a 53-year-old, right-handed man with a history of bipolar disorder who presented with language and behavior impairments characteristic of FTLD, then developed motor symptoms consistent with a second diagnosis of amyotrophic lateral sclerosis. Though the patient had never created visual art before, he developed a compulsion for painting beginning at the earliest stages of his disease, and continued producing art daily until he could no longer lift a paintbrush because of his motor deficits. Upon autopsy, he was found to have ubiquitin and TDP43-positive inclusions with MND pathology. This case study details the patient's longitudinal neuropsychological, emotional, behavioral, and motor symptoms, along with structural imaging, neurologic, and neuropathologic findings. Multiple examples of the patient's art are depicted throughout all stages of his illness, and the possible cognitive, behavioral, and neurologic correlates of his new-onset visual artistry are discussed.
authors.affiliation: University of California San Francisco, CA 94143, USA.
authors.forename: Anli
authors.initials: A
authors.lastname: Liu
authors.forename: Kelly
authors.initials: K
authors.lastname: Werner
authors.forename: Subhojit
authors.initials: S
authors.lastname: Roy
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: Ursula
authors.initials: U
authors.lastname: Morgan-Kane
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Miller
authors.forename: Katherine P
authors.initials: KP
authors.lastname: Rankin
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D001154:Art; D001284:Atrophy / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001714:Bipolar Disorder / Q000150:complications; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D003405:Creativity; D018450:Disease Progression; D004292:Dominance, Cerebral / Q000502:physiology; D004644:Emotions / Q000502:physiology; D017809:Fatal Outcome; D057174:Frontotemporal Lobar Degeneration / Q000150:complications / Q000503:physiopathology / Q000523:psychology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000378:metabolism / Q000473:pathology; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D012920:Social Behavior Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D013116:Spinal Cord / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*