title: [Hepatocellular carcinoma with neoplastic thrombosis of the common hepatic duct].
abstract: Biliary tract involvement in patients with hepatocellular carcinoma usually occurs in advanced stages and is due to tumour compression or infiltration. In a few cases, however, a tumour thrombus may grow into the biliary ducts (bile duct thrombosis). Identification of this condition is important because surgical treatment may be beneficial in selected cases. A 69-year-old man came from another hospital after repeated sessions of radiofrequency thermoablation and alcoholisation of 3 nodules of hepatocellular carcinoma. At admission to our unit, the nodule in S5-S8 was still viable and a neoplastic thrombus had invaded the right and common bile ducts. S5-S8 sub-segmentectomy, S6 wedge resection and removal of the tumour thrombus were performed. Seventeen months later the tumour thrombus recurred in the hepatic ducts without evidence of intrahepatic recurrence and was again removed. Eight months later a large metastatic lymph node appeared at the hepatic hilum, without evidence of liver recurrence or distant metastases, and the patient underwent lymphadenectomy. Eighteen months after the last procedure the patient is alive without recurrence. The appearance of bile duct thrombosis in the natural history of hepatocellular carcinoma does not necessarily entail an unfavourable prognosis. An early diagnosis is crucial to select the appropriate treatment. Biliary decompression with removal of tumour debris and blood clots and curative resection of the hepatocellular carcinoma can result in effective palliation and occasional long-term survival. Also in the presence of intrabiliary, hepatic or limited extrahepatic recurrence, surgical exeresis is the best therapeutic choice in selected cases.
authors.affiliation: Unità Operativa di Chirurgia Generale, Dipartimento di Emergenza/Urgenza - Chirurgia Generale e dei Trapianti, Policlinico S. Orsola-Malpighi, Azienda Ospedaliero-Universitaria di Bologna.
authors.forename: Emilio
authors.initials: E
authors.lastname: De Raffele
authors.forename: Mariateresa
authors.initials: M
authors.lastname: Mirarchi
authors.forename: Francesco
authors.initials: F
authors.lastname: Bassi
authors.forename: Bruno
authors.initials: B
authors.lastname: Cola
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000473:pathology* / Q000601:surgery*; D017115:Catheter Ablation; D000431:Ethanol / Q000008:administration & dosage; D005500:Follow-Up Studies; D006500:Hepatic Duct, Common / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D006979:Hyperthermia, Induced; D008113:Liver Neoplasms / Q000473:pathology* / Q000601:surgery*; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D009361:Neoplasm Invasiveness; D010166:Palliative Care; D011379:Prognosis; D012008:Recurrence; D012086:Reoperation; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000431:Ethanol