title: Lanostane-triterpenoids from the fungus Phellinus gilvus.
abstract: Triterpenoids gilvsins A-D (1-4), with oxygenated lanostane skeletons, were isolated from the fruiting body of Phellinus gilvus, together with two known compounds, 24-methylenelanost-8-ene-3beta, 22-diol and 5alpha-ergosta-7,22-diene-3-one. The structures of 1-4 were deduced from analysis of spectroscopic data. The absolute configuration at C-22 of 1 was determined by the modified Mosher's method and the structure of 1 was confirmed by X-ray analysis. The hypoglycemic activities of the crude extract of P. gilvus and the isolated compounds were also evaluated, but were not promising for further investigation.
authors.affiliation: National Research Institute of Chinese Medicine, Taipei, Taiwan.
authors.forename: Hui-Kang
authors.initials: HK
authors.lastname: Liu
authors.forename: Tung-Hu
authors.initials: TH
authors.lastname: Tsai
authors.forename: Tun-Tschu
authors.initials: TT
authors.lastname: Chang
authors.forename: Cheng-Jen
authors.initials: CJ
authors.lastname: Chou
authors.forename: Lie-Chwen
authors.initials: LC
authors.lastname: Lin
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002460:Cell Line; D045424:Complex Mixtures / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics; D051381:Rats; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D045424:Complex Mixtures; D007004:Hypoglycemic Agents; D014315:Triterpenes; D010729:Phosphoenolpyruvate Carboxykinase (GTP)