Citronamides A and B, tetrapeptides from the Australian sponge Citronia astra.
Two new linear tetrapeptides, citronamides A (1) and B (2), were isolated from the Australian sponge Citronia astra and their structures determined by 1D and 2D NMR spectroscopy. The peptides contain two previously unreported amino acids, 3-(2-oxo-2,3-dihydro-1H-imidazol-4-yl)serine and 6-amino-7-(4-methoxyphenyl)heptanoic acid, and alpha-iduronic acid modified at either C-3 or C-4 with a carbamate. Citronamide A showed moderate antifungal activity against Saccharomyces cerevisiae.
Carroll
Anthony R
AR
Australian Rivers Institute, Griffith University, Gold Coast, Queensland, Australia.
Duffy
Sandra
S
Avery
Vicky M
VM
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001315:Australia; D004926:Escherichia coli / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D014345:Trypanosoma / Q000187:drug effects
D000935:Antifungal Agents; D009842:Oligopeptides; C540699:citronamide A; C540700:citronamide B