Interleukin-17 increased progesterone secretion by JEG-3 human choriocarcinoma cells.
OBJECTIVE
JEG-3 choriocarcinoma cell line has previously been reported to express a receptor for interleukin (IL)-17. The involvement of IL-17 in the production of progesterone and human chorionic gonadotropin by placental trophoblast has not been investigated.


METHODS
The present study investigated the in vitro effect of IL-17 on progesterone and human chorionic gonadotropin (hCG) secretion by JEG-3 cells. Both hormones were quantified using enzyme-linked immunosorbent assays.


RESULTS
The results showed that IL-17 significantly increased progesterone secretion at 6 (P < 0.001) and 24 (P < 0.01) hr, while this cytokine had no effect on hCG secretion.


CONCLUSIONS
Interleukin-17 may regulate the function of JEG-3 cells through increased progesterone secretion.
Pongcharoen
Sutatip
S
Department of Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand. sutatipp@nu.ac.th
Supalap
Kwansuda
K
D045744:Cell Line, Tumor; D002822:Choriocarcinoma / Q000276:immunology / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology; D011247:Pregnancy; D011374:Progesterone / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D053722:Receptors, Interleukin-17 / Q000276:immunology / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D020381:Interleukin-17; D053722:Receptors, Interleukin-17; D011374:Progesterone