Comparison of clinical characteristics between early and late patterns in hospitalized patients with ovarian hyperstimulation syndrome.
OBJECTIVE
To clarify the differences in clinical characteristics between early and late ovarian hyperstimulation syndrome (OHSS).


METHODS
Retrospective study.


METHODS
Tertiary university hospital.


METHODS
Ninety-four patients/cycles hospitalized for moderate-to-severe OHSS after controlled ovarian hyperstimulation (COH) for IVF/intracytoplasmic sperm injection (ICSI); early type (n = 69) and late type (n = 25).


METHODS
None.


METHODS
The COH and pregnancy outcomes, preclinical and clinical miscarriage rate, and hospital courses.


RESULTS
Serum E(2) levels (4,955.5 +/- 3,268.5 pg/mL vs. 2,340.8 +/- 960.6 pg/mL) and the number of follicles > or =11 mm on day of hCG administration (15.9 +/- 6.0 vs. 13.0 +/- 4.0), and the number of oocytes retrieved (21.9 +/- 9.7 vs. 13.2 +/- 5.9) were significantly higher in the early OHSS group compared with the late OHSS group. Clinical pregnancy rate (PR) was significantly higher in the late OHSS group (23.6% [13/55] vs. 92.0% [23/25]). There were no significant differences in multiple PR and disease severity between the two groups.


CONCLUSIONS
Early OHSS is associated with excessive ovarian response to gonadotropin stimulation, whereas late OHSS is closely associated with conception cycle. Our findings do not support that late OHSS is more severe and closely associated with multiple pregnancies compared with early OHSS.
Lee
Kyung Hee
KH
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, Seoul 110-744, South Korea.
Kim
Seok Hyun
SH
Jee
Byung Chul
BC
Kim
Yong Jin
YJ
Suh
Chang Suk
CS
Kim
Ki Chul
KC
Lee
Won Don
WD
D000328:Adult; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000145:classification* / Q000150:complications* / Q000453:epidemiology / Q000209:etiology; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D015995:Prevalence; D027724:Reproductive Techniques, Assisted / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D013997:Time Factors