title: Gastric cancer mortality trends in Tuscany, Italy, 1971-2004.
abstract: AIMS, BACKGROUND, AND METHODS: In Tuscany, Italy, gastric cancer mortality has been decreasing since 1950, although with relevant geographical variability across the region. In Eastern Tuscan areas close to the mountains (high risk areas), gastric cancer mortality has been and is still significantly higher than that recorded in Western coastal areas and in the city of Florence (low risk areas). High-risk areas also showed higher Helicobacter pylori seroprevalence. Aim of this paper is to study gastric cancer mortality trends in high and low-risk areas, during the period 1971-2004, using age-period-cohort models.
  
  
  RESULTS
  In high-risk areas, gastric cancer mortality rates declined from 61.4 per 100,000 in 1971-74 to 19.8 in 2000-2004 and in low-risk areas from 34.9 to 9.8. Mortality decline in high-risk areas was mainly attributable to a birth cohort effect, whereas in low-risk areas it was due either to a birth cohort effect or a period effect. In low- and high-risk areas, birth-cohort risks of dying decreased over subsequent generations, except for the birth cohorts born around the second world war.
  
  
  CONCLUSIONS
  Gastric cancer mortality in areas with higher H. pylori seroprevalence in Tuscany (high-risk areas) showed a predominant decline by birth cohort, in particular for younger generations, possibly due to the decrease of the infection for improvement of living conditions.
authors.affiliation: Environmental and Occupational Epidemiology Unit, Institute for Study and Prevention of Cancer, Florence, Italy. g.gorini@ispo.toscana.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gorini
authors.forename: Lucia
authors.initials: L
authors.lastname: Giovannetti
authors.forename: Giovanna
authors.initials: G
authors.lastname: Masala
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Chellini
authors.forename: Andrea
authors.initials: A
authors.lastname: Martini
authors.forename: Sandra
authors.initials: S
authors.lastname: Mallone
authors.forename: Adele Seniori
authors.initials: AS
authors.lastname: Costantini
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005843:Geography; D016481:Helicobacter Infections / Q000453:epidemiology / Q000401:mortality / Q000821:virology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends*; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000401:mortality* / Q000821:virology; D015996:Survival Rate; D013997:Time Factors