Design of protein-protein interaction inhibitors based on protein epitope mimetics.
On the scaffold: Grafting protein epitopes onto conformationally designed scaffolds represents a very promising approach to protein ligand design, with potential applications in many areas of chemical biology and molecular medicine. The highlighted article describes the design and anticancer activity of novel p53/MDM2 inhibitors built upon a scorpion toxin scaffold. Other approaches to protein epitope mimetics are also briefly discussed.
Robinson
John A
JA
Chemistry Department, University of Zürich, Switzerland. robinson@oci.unizh.ch
D000818:Animals; D040761:Biomimetic Materials / Q000737:chemistry* / Q000494:pharmacology*; D032701:Biomimetics; D015195:Drug Design; D000939:Epitopes / Q000737:chemistry*; D008958:Models, Molecular; D011485:Protein Binding / Q000187:drug effects; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D012604:Scorpion Venoms / Q000737:chemistry / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D000939:Epitopes; D011506:Proteins; D012604:Scorpion Venoms; D016159:Tumor Suppressor Protein p53