Collaborative work on evaluation of ovarian toxicity. 4) Effects of fertility study of 4-vinylcyclohexene diepoxide in female rats.
As part of a collaborative project, 4-vinylcyclohexene diepoxide (VCD), an ovarian toxicant, was intraperitoneally administered to female Sprague-Dawley rats at 0, 5, 20 or 80 mg/kg from 2 weeks prior to mating to Day 7 of gestation. At necropsy, the number of implanted embryos, rate of implantation decreased and the rate of preimplantation loss showed an increasing tendency in the 80 mg/kg group. As for organ weight, decreases in absolute and relative ovary weight were observed in the 80 mg/kg group. Histopathologically, the ovaries showed a decrease in number of small follicles at 80 mg/kg
Kodama
Terutaka
T
Toxicology and Pathology, Nonclinical Developmental Research Department, Pharmaceutical Research Laboratories, Pharmaceutical Company, Ajinomoto Co., Inc., Kawasaki, Kanagawa, Japan. terutaka_kodama@ajinomoto.com
Yoshida
Junichi
J
Miwa
Tadashi
T
Hasegawa
Daiki
D
Masuyama
Takeshi
T
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity*; D053138:Cyclohexenes / Q000008:administration & dosage / Q000633:toxicity*; D010064:Embryo Implantation / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects; D030762:Estrous Cycle / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D007564:Japan; D008136:Longevity / Q000187:drug effects; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D055818:Public-Private Sector Partnerships; D051381:Rats; D017207:Rats, Sprague-Dawley; D012958:Societies, Scientific; D018675:Toxicity Tests / Q000379:methods*; D014753:Vinyl Compounds / Q000008:administration & dosage / Q000633:toxicity*; D015262:Xenobiotics
D002273:Carcinogens; D053138:Cyclohexenes; D014753:Vinyl Compounds; D015262:Xenobiotics; C012606:4-vinyl-1-cyclohexene dioxide