Electrokinetic dispersion of a cancer chemotherapeutic drug for the treatment of solid tumours.
Compromised tumour vascularisation presents a significant challenge to chemotherapeutic-based treatment of solid tumours. In this study we use subtle electric field characteristics to facilitate electrokinetic movement of a cancer chemotherapeutic agent in an ionically complex environment. We demonstrate that such an approach can be exploited to facilitate the electrokinetic movement of camptothecin from a peritumoural site through otherwise relatively impermeable tumour tissues. Here we demonstrate enhanced anti-tumour effects using this approach in a pre-clinical model for solid tumours and suggest one possible therapeutic application of the approach in the treatment of lung cancer.
Nomikou
Nikolitsa
N
School of Biomedical Sciences, University of Ulster, Cromore Rd., Coleraine, Co. Derry BT52 1SA, Northern Ireland, UK.
McHale
Anthony P
AP
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D002166:Camptothecin / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016503:Drug Delivery Systems; D004574:Electromagnetic Fields; D005354:Fibrosarcoma / Q000378:metabolism / Q000473:pathology; D051379:Mice; D009368:Neoplasm Transplantation; D051381:Rats
D000970:Antineoplastic Agents; D002166:Camptothecin