title: Heat shock protein 27 in neuronal survival and neurite outgrowth.
abstract: The small heat shock protein 27 (Hsp27) is well documented to promote neuronal survival in neurodegenerative diseases and following nerve injury. It can directly inhibit apoptotic pathways, and as a chaperone it can ameliorate the toxic effects of misfolded proteins. More recently, Hsp27 has been implicated to also play a role in neurite outgrowth. Thus, Hsp27 is situated at the intersection of neuronal survival and differentiation and, as such, it has dual potential as a key therapeutic target for neuroregeneration.
authors.affiliation: Cell Death and Survival Group, Department of Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland.
authors.forename: Danielle E
authors.initials: DE
authors.lastname: Read
authors.forename: Adrienne M
authors.initials: AM
authors.lastname: Gorman
mesh_terms: D017209:Apoptosis; D002470:Cell Survival; D055551:HSP27 Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D016501:Neurites / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000502:physiology*
chemical_list: D055551:HSP27 Heat-Shock Proteins