An association between resistant hypertension and the null GSTM1 genotype.
Reduction in expression levels of glutathione S-transferase (GST) mu type 1 (GSTM1) in stroke-prone spontaneously hypertensive rats has recently been reported. GSTM1 genotype was evaluated in 49 patients with resistant hypertension and compared with selected patients with controlled hypertension (n=232) and healthy participants (n=110). Null GSTM1 genotype occurred more frequent in patients with resistant hypertension than those with controlled hypertension (57.1 vs 39.7%; P=0.03; RR 1.96; 95% CI 1.04-3.69) suggesting that null GSTM1 genotype may predispose to resistant hypertension.
Cruz-Gonzalez
I
I
Corral
E
E
Sanchez-Ledesma
M
M
Sanchez-Rodriguez
A
A
Martin-Luengo
C
C
Gonzalez-Sarmiento
R
R
D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage; D005260:Female; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D005982:Glutathione Transferase