title: MDM2 309 T/G polymorphism is associated with lung cancer risk among Asians.
abstract: Published data on the association between MDM2 309 T/G polymorphism and lung cancer risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of eight studies including 6063 cases and 6678 controls were involved in this meta-analysis. Overall, significantly elevated lung cancer risk was associated with GG variant genotype in recessive model when all the eligible studies were pooled into the meta-analysis (OR=1.17; 95% CI=1.02-1.34; P(heterogeneity)=0.06). In the subgroup analysis by ethnicity, significantly increased risks were found among Asians for TG versus TT (OR=1.20; 95% CI=1.05-1.37; P(heterogeneity)=0.30), GG versus TT (OR = 1.34; 95% CI=1.01-1.79; P(heterogeneity)=0.03) and dominant model (OR=1.26; 95% CI=1.11-1.43; P(heterogeneity)=0.14). However, no significant associations were found in both Europeans and Africans for all genetic models. This meta-analysis suggests that the MDM2 309G allele is a low-penetrant risk factor for developing lung cancer in Asians.
authors.affiliation: Department of Respiratory Medicine, Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
authors.forename: Xian-Hua
authors.initials: XH
authors.lastname: Gui
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Qiu
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Zhang
authors.forename: De-Ping
authors.initials: DP
authors.lastname: Zhang
authors.forename: Wen-Zhao
authors.initials: WZ
authors.lastname: Zhong
authors.forename: Jin
authors.initials: J
authors.lastname: Li
authors.forename: Yong-Long
authors.initials: YL
authors.lastname: Xiao
mesh_terms: D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D012306:Risk; D012907:Smoking / Q000009:adverse effects
chemical_list: C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2