Emerging drugs for psoriasis.
BACKGROUND
Psoriasis is a relatively common, chronic and disabling skin disease, due to a disturbed proliferation and differentiation of keratinocytes, accompanied by vascular alterations and infiltration of inflammatory cells with a local T(H)1-type cytokine immune response. There is no cure, but several treatment options are available.


OBJECTIVE
The treatment of psoriasis is far from being satisfactory, due to the impractical modalities of topical treatment and the suboptimal safety profile of the systemic treatments available. In the last few years, parallel to an improved understanding of the disease pathogenesis, there has been a boosting of research in new agents for the treatment of psoriasis. These new agents are the focus of this paper.


METHODS
After a short review of the treatment options already available (mainly based on the available systematic reviews), we focused on agents that are still in clinical development (Phase I - III) and have not yet entered the market. For the purpose of this study, we systematically searched the main registries of ongoing trials up to August 2008.


CONCLUSIONS
The field is very dynamic, with both immunopharmacology of recombinant DNA techniques and more traditional small-molecule pharmacology actively delivering new agents. With the increasing number of new options, there is a need for research systems that enable to effectively collect long-term safety data on treated patients.
Naldi
Luigi
L
Department of Dermatology, Ospedali Riuniti, Bergamo, Italy. luigi.naldi@gised.it
Raho
Giovanna
G
D000818:Animals; D002454:Cell Differentiation; D049109:Cell Proliferation; D002986:Clinical Trials as Topic; D016503:Drug Delivery Systems; D006801:Humans; D015603:Keratinocytes / Q000276:immunology; D010778:Photochemotherapy / Q000379:methods; D011565:Psoriasis / Q000188:drug therapy* / Q000503:physiopathology