title: Ghrelin, paraoxonase and arylesterase levels in depressive patients before and after citalopram treatment.
abstract: OBJECTIVE
  The purpose of this study was to examine alterations in lipid profiles and in the serum concentrations of acylated and desacylated ghrelin, paraoxonase and arylesterase in psychiatric patients before and after treatment with 40 mg citalopram daily for 3 months.
  
  
  METHODS
  Samples were collected from 22 healthy controls and 24 psychiatric patients before and after citalopram treatment. Blood levels of acylated and desacylated ghrelin were measured by radioimmunoassay. Paraoxonase and arylesterase activities were determined spectrophotometrically. Lipid parameters were measured on the OLYMPUS-AU400.
  
  
  RESULTS
  It was found that the levels of acylated, desacylated ghrelin, paraoxonase arylesterase, total cholesterol and triglyceride were lower in depressive patients before citalopram treatment than in the control group. Those parameters were not restored after citalopram treatment except for the arylesterase level.
  
  
  CONCLUSIONS
  Decreased PON1 and ghrelin levels as well as fluctuations in lipid profiles may be involved in the etiology of depressive disorders.
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormone Research Group), Firat University, School of Medicine, Firat University Hospital, Elazig, 23119, Turkey.
authors.forename: Abdullah Onder
authors.initials: AO
authors.lastname: Barim
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.forename: Ramis
authors.initials: R
authors.lastname: Colak
authors.forename: Ersel
authors.initials: E
authors.lastname: Dag
authors.forename: Omer
authors.initials: O
authors.lastname: Deniz
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sahin
mesh_terms: D000215:Acylation; D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D043303:Aryldialkylphosphatase / Q000097:blood*; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D015283:Citalopram / Q000627:therapeutic use*; D003710:Demography; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D008297:Male
chemical_list: D018687:Antidepressive Agents, Second-Generation; D054439:Ghrelin; D015283:Citalopram; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase