title: Phenylboronic acid selectively inhibits human prostate and breast cancer cell migration and decreases viability.
abstract: We compared the in vitro effect of boric acid (BA) versus phenylboronic acid (PBA) on the migration of prostate and breast cancer cell lines and non-tumorigenic cells from the same tissues. Treatment at 24 hours with BA (< or =500 microM) did not inhibit chemotaxis on fibronectin in any cell line. However, treatment over the same time course with concentrations of PBA as low as 1 muM significantly inhibited cancer cell migration without effecting non-tumorigenic cell lines. The compounds did not affect cell adhesion or viability at 24 hours but did alter morphology; both decreased cancer cell viability at eight days. These results suggest that PBA is more potent than BA in targeting the metastatic and proliferative properties of cancer cells.
authors.affiliation: Department of Biology, Rensselaer Polytechnic Institute, Troy, New York 12180-3596, USA.
authors.forename: Tiffany M
authors.initials: TM
authors.lastname: Bradke
authors.forename: Casey
authors.initials: C
authors.lastname: Hall
authors.forename: Stephen W
authors.initials: SW
authors.lastname: Carper
authors.forename: George E
authors.initials: GE
authors.lastname: Plopper
mesh_terms: D001888:Boric Acids / Q000494:pharmacology; D001897:Boronic Acids / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000473:pathology*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D005353:Fibronectins / Q000378:metabolism; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000473:pathology*; D013997:Time Factors
chemical_list: D001888:Boric Acids; D001897:Boronic Acids; D005353:Fibronectins; C010686:benzeneboronic acid; C032688:boric acid