The mitochondrial outer membrane protein import machinery: a new player in apoptosis?
The proteins of the BCL-2 family (pBCL-2s) are involved in the sequence of events that culminates in apoptosis, a type I cell death program. The mitochondrion is the primary site of action of pBCL-2s and represents the cross roads between the initiation and the execution phases of apoptosis. pBCL-2s are either constitutively associated with the mitochondria outer membrane (MOM) or targeted to this membrane at the onset of apoptosis. The mechanisms implicated in their targeting and activation during apoptosis is largely unknown. Recently, several pBCL-2s have been shown to interact with components of the translocase of the outer membrane (TOM), a complex responsible for the import into and across the MOM of nuclear encoded mitochondrial proteins. Here we will review the available data and discuss the possible implications of this interaction in the apoptotic programme.
Petit
Elise
E
Equipe 9, Centre de Recherche en Cancerologie Nantes-Angers (U892 INSERM), Nantes, cedex 01, France.
Oliver
Lisa
L
Vallette
Francois M
FM
D017209:Apoptosis; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
D008565:Membrane Proteins; D019253:Proto-Oncogene Proteins c-bcl-2