Inflammatory bowel disease: a paradigm for the link between coagulation and inflammation.
Inflammatory bowel diseases (IBDs) are associated with platelet activation and an increased risk for thromboembolism. While the mechanisms that underlie the altered platelet function and hypercoagulable state in IBD remain poorly understood, emerging evidence indicates that inflammation and coagulation are interdependent processes that can initiate a vicious cycle wherein each process propagates and intensifies the other. This review addresses the mechanisms that may account for the mutual activation of coagulation and inflammation during inflammation and summarizes evidence that implicates a role for platelets and the coagulation system in the pathogenesis of human and experimental IBD. The proposed link between inflammation and coagulation raises the possibility of targeting the inflammation-coagulation interface to reduce the morbidity and mortality associated with IBD.
Yoshida
Hideo
H
Department of Molecular & Cellular Physiology, LSU Health Sciences Center, Shreveport, Louisiana 71130-3932, USA.
Granger
D Neil
DN
D001777:Blood Coagulation; D001778:Blood Coagulation Disorders / Q000150:complications*; D006801:Humans; D007249:Inflammation / Q000150:complications*; D015212:Inflammatory Bowel Diseases / Q000209:etiology*