Serial cytokine levels in patients with severe sepsis.
OBJECTIVE
The serial or dynamic changes of cytokine levels in severely septic patients, between shock and no shock, survivors and non-survivors are still unclear.


METHODS
Seventy-six patients with severe sepsis were enrolled to our study. Plasma levels of interferon-gamma, interleukin (IL)-6, IL-10, IL-12 and transforming growth factor-beta1 from day 1 to day 7 were determined.


RESULTS
IL-6 level in non-survivors was higher than that in survivors on day 1. IL-10 level in non-survivors was higher than that in survivors on day 1, 2, and 3. IL-6 level in shock patients was higher than that in non-shock patients on day 1, 2, 6 and 7. IL-10 level in shock patients was higher than that in non-shock patients from day 1 to day 7. Plasma time-course curves of IL-6 and IL-10 were different between survivors and non-survivors. Plasma time-course curve of IL-6 was different between patients with shock and without shock. Regression analysis found that IL-6 was correlated with IL-10 and shock. IL-10 was correlated with IL-6 and mortality.


CONCLUSIONS
IL-6 and IL-10 were the key cytokines in the pathogenesis of severe sepsis. IL-6 was comparatively more associated with septic shock and IL-10 was comparatively more associated with mortality.
Wu
Huang-Pin
HP
Division of Pulmonary Medicine, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung, #222, Maijin Rd. Anle Chiu, Keelung 204, Taiwan, ROC. whanpyng@cgmh.org.tw
Chen
Chian-Kuang
CK
Chung
Kong
K
Tseng
Jo-Chi
JC
Hua
Chung-Ching
CC
Liu
Yu-Chih
YC
Chuang
Duen-Yau
DY
Yang
Chung-Han
CH
D000368:Aged; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D018805:Sepsis / Q000097:blood* / Q000401:mortality
D016207:Cytokines