title: Genome-wide association study of smoking initiation and current smoking.
abstract: For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.
authors.affiliation: Department of Biological Psychology, Center for Neurogenomic and Cognitive Research, VU University Amsterdam, The Netherlands. jm.vink@psy.vu.nl
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Vink
authors.forename: August B
authors.initials: AB
authors.lastname: Smit
authors.forename: Eco J C
authors.initials: EJ
authors.lastname: de Geus
authors.forename: Patrick
authors.initials: P
authors.lastname: Sullivan
authors.forename: Gonneke
authors.initials: G
authors.lastname: Willemsen
authors.forename: Jouke-Jan
authors.initials: JJ
authors.lastname: Hottenga
authors.forename: Johannes H
authors.initials: JH
authors.lastname: Smit
authors.forename: Witte J
authors.initials: WJ
authors.lastname: Hoogendijk
authors.forename: Frans G
authors.initials: FG
authors.lastname: Zitman
authors.forename: Leena
authors.initials: L
authors.lastname: Peltonen
authors.forename: Jaakko
authors.initials: J
authors.lastname: Kaprio
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Pedersen
authors.forename: Patrik K
authors.initials: PK
authors.lastname: Magnusson
authors.forename: Tim D
authors.initials: TD
authors.lastname: Spector
authors.forename: Kirsten Ohm
authors.initials: KO
authors.lastname: Kyvik
authors.forename: Katherine I
authors.initials: KI
authors.lastname: Morley
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Heath
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Rudi G J
authors.initials: RG
authors.lastname: Westendorp
authors.forename: P Eline
authors.initials: PE
authors.lastname: Slagboom
authors.forename: Henning
authors.initials: H
authors.lastname: Tiemeier
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: Andre G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Yurii S
authors.initials: YS
authors.lastname: Aulchenko
authors.forename: Najaf
authors.initials: N
authors.lastname: Amin
authors.forename: Cornelia
authors.initials: C
authors.lastname: van Duijn
authors.forename: Brenda W
authors.initials: BW
authors.lastname: Penninx
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
mesh_terms: D000328:Adult; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D017470:Receptors, Glutamate / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D012907:Smoking / Q000235:genetics*; D016540:Smoking Cessation
chemical_list: D015815:Cell Adhesion Molecules; D017470:Receptors, Glutamate; D020794:Receptor Protein-Tyrosine Kinases