[Future breakthroughs in medical treatment of age-related conditions].
Significant progress in our understanding of age-related diseases including the metabolic syndrome, type 2 diabetes, arteriosclerosis and cancer have been achieved in recent years. Novel disease-causing mechanisms and, therefore, drug targets, include epigenetics, inflammation, telomeres, mitochondrial function, oxidative stress and sirtuins. There is a need for individualized treatments, and future medical interventions may be initiated in a primary preventive setting by targeting mechanisms similar to those influenced by calorie restriction and physical exercise.
Vaag
Allan
A
Steno Diabetes Center, DK-2820 Gentofte. avaa@steno.dk
Petersen
Jacob Sten
JS
D000368:Aged; D000375:Aging / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D004358:Drug Therapy / Q000639:trends*; D044127:Epigenesis, Genetic; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D018384:Oxidative Stress / Q000187:drug effects; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D010597:Pharmacogenetics / Q000639:trends*; D011322:Primary Prevention; D037761:Sirtuins / Q000235:genetics; D016615:Telomere / Q000187:drug effects
D004364:Pharmaceutical Preparations; D037761:Sirtuins