title: Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1.
abstract: Thiodipeptide prodrugs of the ketone nabumetone are shown to have affinity for, and be transported by, PepT1 in vitro.
authors.affiliation: School of Chemistry, University of Manchester, Manchester, M13 9PL, UK. david.foley@postgrad.manchester.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Foley
authors.forename: Patrick
authors.initials: P
authors.lastname: Bailey
authors.forename: Myrtani
authors.initials: M
authors.lastname: Pieri
authors.forename: David
authors.initials: D
authors.lastname: Meredith
mesh_terms: D001692:Biological Transport; D002074:Butanones / Q000737:chemistry*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007421:Intestine, Small / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D000077430:Nabumetone; D000074011:Peptide Transporter 1; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D027981:Symporters / Q000737:chemistry / Q000378:metabolism*
chemical_list: D002074:Butanones; D004151:Dipeptides; D007659:Ketones; D000074011:Peptide Transporter 1; D011355:Prodrugs; C082186:SLC15A1 protein, human; D013438:Sulfhydryl Compounds; D027981:Symporters; D000077430:Nabumetone