Clozapine-associated weight loss.
Clozapine is associated with weight gain. We report three patients with substantial weight loss following treatment with clozapine. The weight loss observed in the three patients was 33, 18 and 14.4 kg with percentage loss of body weight of 49, 18 and 21 respectively. Two patients had diabetes mellitus. History, physical examination and extensive investigations in the three patients did not reveal any cause that could account for the weight loss.
Hanwella
R
R
Department of Psychological Medicine, Faculty of Medicine, Colombo, Sri Lanka.
de Silva
V
V
Wijeratne
C
C
Ketharanathan
T
T
de Silva
J
J
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015992:Body Mass Index; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D048909:Diabetes Complications / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000150:complications / Q000188:drug therapy; D015431:Weight Loss / Q000187:drug effects*
D014150:Antipsychotic Agents; D003024:Clozapine