Preparation and characterization of amino-functionalized magnetic nanogels via photopolymerization for MRI applications.
To design peptide-targeted iron oxide as magnetic resonance imaging (MRI) contrast agents, amino-functionalized magnetic nanogels were prepared by using N-(2-aminoethyl) methacrylamide hydrochloride (AEM x HCl) as monomer via new photochemical approach. Their chemical structure and composition were characterized by Fourier transform infrared spectra (FTIR) and thermogravimetric analyses (TGA). The core-shell structure of magnetic nanogels was confirmed by high-resolution transmission electron microscopy (HRTEM). The good storage stability, high magnetic content (88.7%), high saturation magnetizations and superparamagnetic behavior suggested their great potentials as MRI contrast agents, which were confirmed by their measurements of r(2) and coronal image of the crossing of mouse kidney.
Gong
Yanbao
Y
College of New Drug Innovation Research & Development, East China Normal University, Shanghai 200062, PR China.
Fan
Mingxia
M
Gao
Feng
F
Hong
Jun
J
Liu
Shunying
S
Luo
Shufang
S
Yu
Jiahui
J
Huang
Jin
J
D000588:Amines / Q000737:chemistry*; D000818:Animals; D005290:Ferric Compounds / Q000737:chemistry; D007668:Kidney / Q000033:anatomy & histology; D008027:Light; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D051379:Mice; D000080385:Nanogels; D053758:Nanoparticles / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012542:Scattering, Radiation; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry; D013997:Time Factors
D000588:Amines; D005290:Ferric Compounds; D000080385:Nanogels; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; C000499:ferric oxide; D011092:Polyethylene Glycols; D011094:Polyethyleneimine