title: Stability of vitamin A palmitate in cosmetic emulsions: influence of physical parameters.
abstract: Synopsis The aim of this work was to verify if a close relationship exists between the physical stability of an emulsion and the chemical stability of vitamin A palmitate included in it. Oil-in-water cosmetic emulsions with high viscoelastic properties were prepared, and their rheological behaviour was investigated in oscillatory conditions. The stability of each sample was verified in high-temperature stress conditions: periodical checks of physical parameters and chromatographic analysis of vitamin A were performed during storage. Results show that the chemical stability of vitamin A palmitate strictly depends on the physical stability of the formulation and in particular on the presence of a coherent gel-like structure in the external phase of the emulsion.
authors.affiliation: Centro di Cosmetologia Chimica dell'Università di Padova, Dipartimento di Scienze Farmaceutiche, Via Marzolo 5, 35131 Padova, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Semenzato
authors.forename: A
authors.initials: A
authors.lastname: Baù
authors.forename: C
authors.initials: C
authors.lastname: Dall'aglio
authors.forename: M
authors.initials: M
authors.lastname: Nicolini
authors.forename: A
authors.initials: A
authors.lastname: Bettero
authors.forename: I
authors.initials: I
authors.lastname: Calliari