IRS-2 and its involvement in diabetes and aging.
Insulin receptor substrate 2 (IRS-2) is a key molecule in insulin signaling pathway, serving as an adaptor protein to insulin receptor to activate downstream kinase cascades, including MAP kinase and PI-3 kinase cascades. While reduced IRS-2 expression is tightly associated with diabetes and insulin resistance in various rodent diabetic models, this gene is also suggested to play a critical role in reproductive system and pancreas development. Recently, IRS-2 is demonstrated to be actively involved in lifespan regulation. In this chapter, we attempt to give a brief review of what we have learned about this molecule in metabolism and growth.
Zhang
Jiandi
J
Rigel Pharmaceuticals, Inc., South San Francisco, California 94080, USA.
Sun
Tian-Qiang
TQ
D000375:Aging / Q000502:physiology*; D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D055504:Insulin Receptor Substrate Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007448:Invertebrates; D008322:Mammals
D055504:Insulin Receptor Substrate Proteins