C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.
Inflammation is believed to play a role in prostate cancer (PCa) etiology, but it is unclear whether inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6) associate with PCa risk in older men. Using Cox regression, we assessed the relationship between baseline concentrations of CRP and IL-6 and the subsequent PCa risk in the Cardiovascular Health Study, a population-based cohort study of mostly European American men of ages >64 years (n = 2,234; mean follow-up = 8.7 years; 215 incident PCa cases). We also tested associations between CRP and IL-6 tagSNPs and PCa risk, focusing on SNPs that are known to associate with circulating CRP and/or IL-6. Neither CRP nor IL-6 blood concentrations was associated with PCa risk. The C allele of IL-6 SNP rs1800795 (-174), a known functional variant, was associated with increased risk in a dominant model (HR = 1.44; 95% CI = 1.03-2.01; p = 0.03), but was not statistically significant after accounting for multiple tests (permutation p = 0.21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation.
Pierce
Brandon L
BL
Institute for Public Health Genetics, University of Washington, Seattle, WA, USA. bpierce@health.bsd.uchicago.edu
Biggs
Mary L
ML
DeCambre
Marvalyn
M
Reiner
Alexander P
AP
Li
Christopher
C
Fitzpatrick
Annette
A
Carlson
Christopher S
CS
Stanford
Janet L
JL
Austin
Melissa A
MA
D001741:Black or African American; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000150:complications; D015850:Interleukin-6 / Q000097:blood* / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000378:metabolism; D012307:Risk Factors; D044465:White People
D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein