title: Ecdysteroids and a sucrose phenylpropanoid ester from Froelichia floridana.
abstract: Phytoecdysteroid glycosides (1-5) and a phenylpropanoid ester of sucrose (6) were isolated from the whole plant of Froelichia floridana, along with eight known compounds including three ecdysteroids (7-9), four flavonoids (10-13), and one phenolic compound (14). Structures were determined using a combination of spectroscopic techniques. Compounds 1, 2 and 6-14 were tested in vitro for their activity against human DNA topoisomerase I. Compound 13 (diosmetin) showed marginal inhibition against topoisomerase I with IC(50) of 130 microM in conjunction with low intercalation ability.
authors.affiliation: National Center for Pharmaceutical Crops, Arthur Temple College of Forestry and Agriculture, Stephen F. Austin State University, Nacogdoches, TX 75962, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Shiyou
authors.initials: S
authors.lastname: Li
authors.forename: Stacy
authors.initials: S
authors.lastname: Ownby
authors.forename: Zhizhen
authors.initials: Z
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Yuan
authors.forename: Wanli
authors.initials: W
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: Scott Beasley
mesh_terms: D027703:Amaranthaceae / Q000737:chemistry*; D026461:Ecdysteroids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D004952:Esters / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors
chemical_list: D026461:Ecdysteroids; D004952:Esters; D005419:Flavonoids; D010636:Phenols; D059004:Topoisomerase I Inhibitors