Expression and prognostic significance of human growth and transformation-dependent protein in gastric carcinoma and gastric adenoma.
Human growth and transformation-dependent protein is a hypoxia-responsive, proapoptotic protein downstream of hypoxia-inducible factor 1alpha. Its function and expression pattern in human cancers are largely unknown. We investigated the expression profile of human growth and transformation-dependent protein using immunohistochemistry in gastric tissues including cancer (n = 138), adenoma (n = 37), intestinal metaplasia (n = 20), and normal gastric epithelium (n = 20), then correlated human growth and transformation-dependent protein expression in tumors with clinicopathologic features. Human growth and transformation-dependent protein showed strong staining in the cytoplasm of intestinal-type adenocarcinoma and gastric adenoma, whereas normal gastric antral mucosa showed no staining. Human growth and transformation-dependent protein expression in gastric cancer showed a close association with the Lauren classification, tumor stage, and Ki-67 proliferation index. These findings suggest that human growth and transformation-dependent protein expression is a common occurrence during the progression from a normal gastric mucosa to an intestinal-type carcinoma and may be associated with tumor cell proliferation activity.
Cho
Young-Eun
YE
Department of Pathology and Medical Research Center for Bioreaction to Reactive Oxygen Species, School of Medicine, Kyung Hee University, Seoul 130-701, Korea.
Kim
Jee-Youn
JY
Kim
Youn-Wha
YW
Park
Jae-Hoon
JH
Lee
Sun
S
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008297:Male; D008565:Membrane Proteins / Q000096:biosynthesis*; D008679:Metaplasia / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D024101:Mitochondrial Proteins / Q000096:biosynthesis*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
C486647:FAM162A protein, human; D019394:Ki-67 Antigen; D008565:Membrane Proteins; D024101:Mitochondrial Proteins