title: Skin necrosis after self-administered intramuscular diclofenac.
abstract: Intramuscular diclofenac is used extensively for pain relief in medical practice. Tissue necrosis is a rare but serious complication of intramuscular injections. The pathogenetic mechanism is still not completely understood. A case of tissue necrosis following self-administration of diclofenac inadvertently injected into an arterial perforator branch of the superficial femoral artery is reported, supporting a vascular pathogenesis.
authors.affiliation: Department of Orthopedics A, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, 6 Weizman Street, Tel-Aviv 64239, Israel. ofiruri@gmail.com
authors.forename: Ofir
authors.initials: O
authors.lastname: Uri
authors.forename: Ehud
authors.initials: E
authors.lastname: Arad
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001416:Back Pain / Q000188:drug therapy; D002481:Cellulitis / Q000139:chemically induced* / Q000601:surgery; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced* / Q000601:surgery; D012646:Self Administration / Q000009:adverse effects; D012867:Skin / Q000187:drug effects; D013203:Staphylococcal Infections / Q000628:therapy; D013530:Surgical Wound Infection / Q000382:microbiology / Q000628:therapy; D013848:Thigh
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac