title: Antimalarial bromophycolides J-Q from the Fijian red alga Callophycus serratus.
abstract: Bromophycolides J-Q (1-8) were isolated from extracts of the Fijian red alga Callophycus serratus and identified with 1D and 2D NMR spectroscopy and mass spectral analyses. These diterpene-benzoate macrolides represent two novel carbon skeletons and add to the 10 previously reported bromophycolides (9-18) from this alga. Among these 18 bromophycolides, several exhibited activities in the low micromolar range against the human malaria parasite Plasmodium falciparum.
authors.affiliation: School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Lane
authors.forename: E Paige
authors.initials: EP
authors.lastname: Stout
authors.forename: An-Shen
authors.initials: AS
authors.lastname: Lin
authors.forename: Jacques
authors.initials: J
authors.lastname: Prudhomme
authors.forename: Karine
authors.initials: K
authors.lastname: Le Roch
authors.forename: Craig R
authors.initials: CR
authors.lastname: Fairchild
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: Mark E
authors.initials: ME
authors.lastname: Hay
authors.forename: William
authors.initials: W
authors.lastname: Aalbersberg
authors.forename: Julia
authors.initials: J
authors.lastname: Kubanek
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects; D000461:Rhodophyta / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D004224:Diterpenes