title: Feasibility of implementing a reduced fasting protocol for critically ill trauma patients undergoing operative and nonoperative procedures.
abstract: BACKGROUND
  This prospective, observational cohort study was designed to determine the feasibility of implementing a reduced enteral fasting protocol in mechanically ventilated trauma patients undergoing selected operative and nonoperative procedures.
  
  
  METHODS
  Critically ill, mechanically ventilated trauma patients undergoing selected operative and nonoperative procedures received enteral nutrition up until the time of the procedure, if receiving small bowel feeds, or received enteral nutrition that was discontinued 45 minutes before the procedure, if receiving gastric feeds.
  
  
  RESULTS
  Measures of delivery of nutrition such as total enteral nutrition delivered and days required to reach nutrition goal were collected. Complications measured were death, incidence of ventilator-associated pneumonia, urinary tract infection, catheter-related bloodstream infection, wound infection, hypoglycemia, and emesis during procedures. No significant demographic differences were observed between the 2 groups. Patients in the intervention group showed trends toward greater total enteral nutrition delivered and faster attainment of target nutrition goals, although these measures were not statistically significant. Patients in the intervention group had rates of infective complications similar to those in the standard group. The median (interquartile range) for intensive care unit length of stay in the intervention group vs standard group was 7 (5, 15) vs 7 (5, 12) (P = 0.94), and the ventilator days were 8 (4.2, 14) vs 7 (3, 11) (P = 0.37).
  
  
  CONCLUSIONS
  A reduced fasting protocol was feasible for selected operative procedures, with trends toward improving nutrition delivery and no increase in adverse outcomes. A larger randomized study of this approach is warranted before adoption of this practice can be advocated.
authors.affiliation: Department of Anesthesiology, David Geffen School of Medicine at UCLA, West Los Angeles VA, Los Angeles, California, USA. frostitude@yahoo.com
authors.forename: Robert M
authors.initials: RM
authors.lastname: Pousman
authors.forename: Colleen
authors.initials: C
authors.lastname: Pepper
authors.forename: Pratik
authors.initials: P
authors.lastname: Pandharipande
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Ayers
authors.forename: Beth
authors.initials: B
authors.lastname: Mills
authors.forename: Jose
authors.initials: J
authors.lastname: Diaz
authors.forename: Brian
authors.initials: B
authors.lastname: Collier
authors.forename: Rick
authors.initials: R
authors.lastname: Miller
authors.forename: Gordon
authors.initials: G
authors.lastname: Jensen
mesh_terms: D018806:APACHE; D000328:Adult; D015331:Cohort Studies; D016638:Critical Illness / Q000628:therapy*; D004750:Enteral Nutrition; D005215:Fasting / Q000502:physiology*; D005240:Feasibility Studies; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011300:Preoperative Care / Q000379:methods*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012121:Respiration, Artificial; D013997:Time Factors; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000601:surgery / Q000628:therapy*