title: Quantum dots-based immunofluorescence technology for the quantitative determination of HER2 expression in breast cancer.
abstract: HER2 detection is important for breast cancer (BC) treatment and prognosis, but the detection methods currently used have some disadvantages. Quantum dots (QDs)-based probes provide a potentially important new method for HER2 detection in clinical practice. This potential is examined in this paper. A QDs HER2 probe kit and QDs image acquisition and analysis software were developed and applied to 94 clinical samples of BC. Compared to conventional immunohistochemistry techniques, this method provided a superior accurate and sensitive method for the detection of HER2 in clinical breast cancer diagnosis.
authors.affiliation: Department of Oncology, Zhongnan Hospital of Wuhan University, Wuchang District, PR China.
authors.forename: Chuang
authors.initials: C
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Peng
authors.forename: He-Shun
authors.initials: HS
authors.lastname: Xia
authors.forename: Gui-Fang
authors.initials: GF
authors.lastname: Yang
authors.forename: Qiong-Shui
authors.initials: QS
authors.lastname: Wu
authors.forename: Liang-Dong
authors.initials: LD
authors.lastname: Chen
authors.forename: Li-Bo
authors.initials: LB
authors.lastname: Zeng
authors.forename: Zhi-Ling
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Dai-Wen
authors.initials: DW
authors.lastname: Pang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics*; D005240:Feasibility Studies; D005455:Fluorescent Antibody Technique; D018734:Genes, erbB-2; D006801:Humans; D045663:Quantum Dots; D012680:Sensitivity and Specificity