title: Molecular mechanisms of macrolide resistance in clinical isolates of Mycoplasma pneumoniae from China.
abstract: Fifty clinical Mycoplasma pneumoniae strains were isolated from 370 children with respiratory tract infections. Four strains were susceptible to macrolides, while the other 46 (92%) were macrolide resistant. The molecular mechanism of resistance was shown to be associated with point mutations in 23S rRNA at positions 2063 and 2064.
authors.affiliation: Pediatric Department of Beijing Friendship Hospital, Capital Medical University, No. 95, Yongan Road, XuanWu District, Beijing 100050, China. xindl48@sina.com.cn
authors.forename: Deli
authors.initials: D
authors.lastname: Xin
authors.forename: Zuhuang
authors.initials: Z
authors.lastname: Mi
authors.forename: Xu
authors.initials: X
authors.lastname: Han
authors.forename: Ling
authors.initials: L
authors.lastname: Qin
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Tianli
authors.initials: T
authors.lastname: Wei
authors.forename: Xiaogeng
authors.initials: X
authors.lastname: Chen
authors.forename: Shaojie
authors.initials: S
authors.lastname: Ma
authors.forename: Ancun
authors.initials: A
authors.lastname: Hou
authors.forename: Gui
authors.initials: G
authors.lastname: Li
authors.forename: Dawei
authors.initials: D
authors.lastname: Shi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002681:China; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D011019:Pneumonia, Mycoplasma / Q000382:microbiology; D017354:Point Mutation; D012338:RNA, Ribosomal, 23S / Q000235:genetics*; D012141:Respiratory Tract Infections / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; D012338:RNA, Ribosomal, 23S