title: [Research progress on genetic diversity of sheep PRNP and resistance breeding].
abstract: Prion protein (PrP) is a pathogeny identified in recent years, which infects both mankind and other mammals. It has been proved that PrP is a sole protein able to duplicate and propagate with itself. PrP can express in many tissues and has important physiological functions in many species of animals. The conformation change of PrP is the origin of transmissible spongiform encephalopathies (TSEs). It has been proved that the sheep genetic diversity of prion protein gene (PRNP) is significantly associated with the resistance to scrapie. In this review, the evidence of association between polymorphisms of PRNP and resistance or susceptibility to scrapie and its effects on reproduction and performance traits were focused. The aim is to provide theory guidance for sheep breeding resistant to disease.
authors.affiliation: College of Life Sciences, China Jiliang University, Hangzhou 310018, China. jlguanfeng@yahoo.com.cn
authors.forename: Feng
authors.initials: F
authors.lastname: Guan
authors.forename: Lei
authors.initials: L
authors.lastname: Pan
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Shi
authors.forename: Shou-Ren
authors.initials: SR
authors.lastname: Liu
authors.forename: Li-Guo
authors.initials: LG
authors.lastname: Yang
mesh_terms: D000818:Animals; D001669:Biochemical Phenomena; D001947:Breeding / Q000379:methods*; D015870:Gene Expression; D014644:Genetic Variation; D007113:Immunity, Innate / Q000235:genetics; D011110:Polymorphism, Genetic; D017096:Prion Diseases / Q000235:genetics*; D011328:Prions / Q000235:genetics*; D012608:Scrapie / Q000235:genetics* / Q000635:transmission; D012756:Sheep / Q000235:genetics*; D012757:Sheep Diseases / Q000635:transmission*
chemical_list: D011328:Prions