title: Design, synthesis and anti-HIV integrase evaluation of 4-oxo-4H-quinolizine-3-carboxylic acid derivatives.
abstract: 4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by (1)H-NMR, (13)C- NMR, IR and ESI (or HRMS) spectra. Compounds were screened for possible HIV integrase inhibitory activity.
authors.affiliation: Beijing University of Technology, P. R. China. xuys@craes.org.cn
authors.forename: Yi-Sheng
authors.initials: YS
authors.lastname: Xu
authors.forename: Cheng-Chu
authors.initials: CC
authors.lastname: Zeng
authors.forename: Zi-Guo
authors.initials: ZG
authors.lastname: Jiao
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Hu
authors.forename: Ru-gang
authors.initials: RG
authors.lastname: Zhong
mesh_terms: D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D019427:HIV Integrase / Q000378:metabolism*; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008274:Magnesium / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D002264:Carboxylic Acids; D019428:HIV Integrase Inhibitors; D011807:Quinolizines; D019427:HIV Integrase; D008274:Magnesium