Decreased IgA antibody production in the stomach of gastric adenocarcinoma patients.
Gastric adenocarcinoma is closely associated with Helicobacter pylori infection. It is also much more frequent in patients with common variable immunodeficiency or selective IgA-deficiency than in the general population. To investigate a possible link between local antibody production and gastric tumors, we studied gastric B cell infiltration and local IgA production in patients with H. pylori induced gastric adenocarcinomas. These studies showed that total and H. pylori-specific IgA antibody levels were substantially lower in gastric tissue from the cancer patients compared to those from asymptomatic H. pylori carriers. However, serum IgA levels were similar in the cancer patients and asymptomatic carriers. As could be expected, H. pylori infected asymptomatic carriers had considerably increased IgA antibody levels compared to uninfected subjects. We conclude that patients suffering from gastric adenocarcinoma have a dramatically decreased local IgA production in the stomach compared to asymptomatic H. pylori infected individuals.
Quiding-Järbrink
Marianne
M
Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, The Sahlgrenska Academy at University of Gothenburg, Sweden. marianne.quiding@microbio.gu.se
Sundström
Patrik
P
Lundgren
Anna
A
Hansson
Malin
M
Bäckström
Malin
M
Johansson
Camilla
C
Enarsson
Karin
K
Hermansson
Michael
M
Johnsson
Erik
E
Svennerholm
Ann-Mari
AM
D000230:Adenocarcinoma / Q000276:immunology* / Q000382:microbiology; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology*; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D013274:Stomach Neoplasms / Q000276:immunology* / Q000382:microbiology; D014510:Urease / Q000276:immunology / Q000378:metabolism
D000907:Antibodies, Bacterial; D018925:Chemokines; D007070:Immunoglobulin A; D014510:Urease