title: Soluble endoglin and transforming growth factor-beta1 in women who subsequently developed preeclampsia.
abstract: OBJECTIVE
  This study aimed to analyze the differences of soluble endoglin (sEng) and transforming growth factor-beta1 (TGF-beta1) according to preeclamptic complications and to investigate the correlation between these factors and the clinical symptoms of preeclampsia.
  
  
  METHODS
  We estimated the levels of sEng and TGF-beta1 in plasma collected in the second trimester at the time of genetic amniocentesis from 60 women who subsequently developed preeclampsia and 124 contemporaneous normotensive women.
  
  
  RESULTS
  sEng levels were higher in cases than in controls, whereas TGF-beta1 levels were lower (P < 0.001). sEng levels, but not TGF-beta1 levels, were higher in cases with severe or preterm delivery than in cases with mild preeclampsia or term delivery (P < 0.001) and were increased in cases destined to deliver a small gestational age neonate (P < 0.001). Moreover, sEng levels, but not TGF-beta1 levels, showed a positive correlation with maximum diastolic and systolic blood pressure (r = 0.57, P < 0.001; and r = 0.33, P < 0.001, respectively) and proteinuria (r = 0.42, P < 0.001).
  
  
  CONCLUSIONS
  Early midtrimester plasma levels of sEng are predictive of subsequence occurrence and severity of preeclampsia, in terms of severity of hypertension and proteinuria, prematurity, and association with small for gestational age neonates.
authors.affiliation: The Laboratory of Medical Genetics, Medical Research Institute, Cheil General Hospital and Women's Healthcare Center, Seoul, Korea.
authors.forename: Ji Hyae
authors.initials: JH
authors.lastname: Lim
authors.forename: Shin Young
authors.initials: SY
authors.lastname: Kim
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Park
authors.forename: Moon Hee
authors.initials: MH
authors.lastname: Lee
authors.forename: Jae Hyug
authors.initials: JH
authors.lastname: Yang
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Jin Hoon
authors.initials: JH
authors.lastname: Chung
authors.forename: Si Won
authors.initials: SW
authors.lastname: Lee
authors.forename: Hyun Mee
authors.initials: HM
authors.lastname: Ryu
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D016022:Case-Control Studies; D003944:Diagnostic Techniques, Obstetrical and Gynecological; D000071063:Endoglin; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000097:blood*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D053773:Transforming Growth Factor beta1 / Q000097:blood*
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D053773:Transforming Growth Factor beta1