title: Pd(II)/Pd(IV) catalytic enantioselective synthesis of bicyclo[3.1.0]hexanes via oxidative cyclization of enynes.
abstract: The first asymmetric Pd(II)/Pd(IV) catalysis has been achieved by employing the combination of a hypervalent iodine reagent and a chiral ligand, SPRIX. Enantioselective cyclization of enyne derivatives catalyzed by the Pd-i-Pr-SPRIX complex furnished lactones bearing a bicyclo[3.1.0]hexane skeleton with up to 95% ee.
authors.affiliation: Department of Medicinal Organic Chemistry, School of Pharmacy, Iwate Medical University, Yahaba, Iwate 028-3694, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tsujihara
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Takenaka
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Onitsuka
authors.forename: Minoru
authors.initials: M
authors.lastname: Hatanaka
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Sasai
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D010084:Oxidation-Reduction; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D001643:Bridged Bicyclo Compounds; C046059:bicyclo(3.1.0)hexane; D010165:Palladium