title: [Glucose metabolism alterations and follow-up study of a non-diabetic adult population].
abstract: OBJECTIVE
  To determine the appearance of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) at five years of follow-up in a known non-diabetic population.
  
  
  METHODS
  
  
  
  METHODS
  nested case control studies (case s-control into a cohort) developed in two stages: 1) identification and characterization of the cohort and 2) follow-up.
  
  
  METHODS
  representative sample of a non-diabetic population between 40 and 75 years old attended in a Primary Health Center.
  
  
  RESULTS
  
  
  
  METHODS
  326 persons, 2.1% of whom were diagnosed of previously unknown DM2 and 7.3% of IFG. Insulin resistance (IR) was higher in patients with IFG and pancreatic function of beta cells (PFBC) was higher in the population without glucose metabolism alteration.
  
  
  RESULTS
  121 persons, 9.7 % of whom evolved to DM2 (all with IFG). IFG proportion at the end of the follow-up was 23.96%.
  
  
  CONCLUSIONS
  At 5 years of follow-up, more than 1/3 of the population studied developed DM2 or IFG. These diagnoses were related with IR and PFBC.
authors.affiliation: Centro de Atención Primaria Terrassa Nord, Consorci Sanitari de Terrassa, Terrassa, Barcelona, España. mvernet@cst.cat
authors.forename: M
authors.initials: M
authors.lastname: Vernet Vernet
authors.forename: M J
authors.initials: MJ
authors.lastname: Sender Palacios
authors.forename: E
authors.initials: E
authors.lastname: Jovell Fernández
authors.forename: R
authors.initials: R
authors.lastname: Casals Riera
authors.forename: E
authors.initials: E
authors.lastname: Tor Figueras
authors.forename: J
authors.initials: J
authors.lastname: Anglada Barceló
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D016022:Case-Control Studies; D003920:Diabetes Mellitus / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D044882:Glucose Metabolism Disorders / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D001786:Blood Glucose