title: Intravenous flurbiprofen axetil can increase analgesic effect in refractory cancer pain.
abstract: BACKGROUND
  The aim of this study was to investigate the analgesic effects of intravenous flurbiprofen axetil for the refractory pain in cancer patients.
  
  
  METHODS
  2109 patients were screened from the department of medical oncology, the first affiliated hospital of Anhui medical university in China between October of 2007 and October of 2008. Thirty-seven cases of cancer patients who had bad effect from anaesthetic drugs were received administration of intravenous flurbiprofen axetil with dose of 50 mg/5 ml/day. The pain score was evaluated for pre- and post- treatment by Pain Faces Scale criteria, and the side effects were also observed.
  
  
  RESULTS
  Intravenous flurbiprofen axetil increased the analgesic effects. The total effective rate was 92%. The side effects, such as abdominal pain, alimentary tract bleeding which were found in using NSAIDs or constipation, nausea, vomit, sleepiness which were found in using opioid drugs did not be found.
  
  
  CONCLUSIONS
  Intravenous flurbiprofen axetil could provide better analgesia effects and few side effects to patients with refractory cancer pain. It could also increase analgesia effects when combining with anesthetic drugs in treatment of moderate or severe pain, especially breakthrough pain, and suit to patients who can not take oral drugs for the reason of constipation and psychosomatic symptoms.
authors.affiliation: Department of Medical Oncology, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, PR China. why970@yahoo.com.cn
authors.forename: Hongyang
authors.initials: H
authors.lastname: Wu
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Chen
authors.forename: Guoping
authors.initials: G
authors.lastname: Sun
authors.forename: Kangsheng
authors.initials: K
authors.lastname: Gu
authors.forename: Yueyin
authors.initials: Y
authors.lastname: Pan
authors.forename: Jiqing
authors.initials: J
authors.lastname: Hao
authors.forename: Yingying
authors.initials: Y
authors.lastname: Du
authors.forename: Jie
authors.initials: J
authors.lastname: Ning
mesh_terms: D000698:Analgesia / Q000379:methods*; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications*; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology; D011355:Prodrugs / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D011355:Prodrugs; D005480:Flurbiprofen; C504422:flurbiprofen axetil