title: Intra-anal condyloma: surgical or topical treatment?
abstract: Human Papillomavirus infections are the strongest risk factors for genital cancer and are the causative agents of anogenital warts. Although the viral types associated with condylomata usually do not cause carcinoma, in women with a history of these lesions there is an increased risk of intraepithelial neoplasia and cancer. Generally the lesions are not life-threatening, but they provoke significant morbidity, are difficult to treat, and are a source of psychosocial stress. Thus, condylomata represent not only a health problem for the patient but also an economic burden for the society. Considering the individual episodes of care, men experience a longer duration of the lesions and incur greater costs than women. We report a case of a male patient with external and intra-anal condyloma resistant to laser therapy. Initially, surgical intervention appeared required because of florid and intra-anal growth. HPV DNA testing and sequencing revealed the presence of HPV 6. After initial discomfort, the lesions were successfully cleared with topical imiquimod 5 percent cream therapy.
authors.affiliation: Department of Dermatology, "Campus Biomedico," University of Rome, Italy. c.dianzani@unicampus.it
authors.forename: Caterina
authors.initials: C
authors.lastname: Dianzani
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pierangeli
authors.forename: Alessandra
authors.initials: A
authors.lastname: Avola
authors.forename: Domenico
authors.initials: D
authors.lastname: Borzomati
authors.forename: Paolo
authors.initials: P
authors.lastname: Persichetti
authors.forename: Anna Marta
authors.initials: AM
authors.lastname: Degener
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000634:Aminoquinolines / Q000008:administration & dosage*; D001003:Anal Canal; D001004:Anus Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery* / Q000821:virology; D003218:Condylomata Acuminata / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery* / Q000821:virology; D006801:Humans; D000077271:Imiquimod; D053685:Laser Therapy; D008297:Male; D009824:Ointments; D019233:Retreatment; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery* / Q000821:virology; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D009824:Ointments; D000077271:Imiquimod