LDV assessment of methyl nicotinate biological response in aqueous solution against that of a w/o microemulsion system.
Synopsis The aim of this work was to check if the specific microstructure of a water/oil nonionic microemulsion could induce a modification of the bioavailability of a probe (methyl nicotinate). The vasodilatory drug effects were recorded by laser doppler velocimetry in vivo, in man. The results show a quicker activity, and a better release of the drug in the microemulsion, than in the well-known kinetics of an aqueous solution.
Meloni
M
M
Faculté des Sciences Pharmaceutiques et Biologiques de l'Université René Descartes - Paris V - 4, Avenue de L'Observatoire, 75006 Paris, France.
Poelman
M C
MC
Lavazza
M
M