title: Ovarian epithelial dysplasia and prophylactic oophorectomy for genetic risk.
abstract: To make an accurate histopathological description of ovarian dysplasia in a population at genetic risk of ovarian cancer and devise an ovarian dysplasia score.
  
  
  METHODS
  In this retrospective cohort study, 90 patients who had undergone bilateral oophorectomy or ovarian cystectomy between 1992 and 2005 and whose ovaries were reported as normal were divided into two groups: Group A comprising prophylactic oophorectomies for genetic predisposition (N = 28), and Group B or control group, fertile and non-cancerous (N = 62). Eleven epithelial cytological and architectural features were defined. Ovaries were analysed and reviewed by four pathologists blinded to clinical data. An ovarian dysplasia score was devised to quantify extent of ovarian epithelial abnormalities. The degrees of ovarian epithelial abnormalities (dysplasia scores) were compared between the two groups.
  
  
  RESULTS
  Mean dysplasia score was significantly higher in Group A (prophylactic oophorectomies) than in Group B (control group) (9.67 vs. 4.19, P < 0.001). In Group A, we observed a gradation in the severity of the dysplastic lesions between (i) proven BRCA mutations and prophylactic oophorectomies without mutations (11.26 vs. 8.1), and (ii) according to age (10.27 after age 50 years vs. 8.6 before age 50 years, P = 0.2962).
  
  
  CONCLUSIONS
  These results suggest abnormalities in ovaries from high risk women. The ovarian dysplasia may be a pre-malignant, non-invasive histological lesion that could be an important step in early neoplasia.
authors.affiliation: Department of Surgery, Centre Jean Perrin, rue Montalembert, Clermont-Ferrand, France. chenegautier@yahoo.fr
authors.forename: Gautier
authors.initials: G
authors.lastname: Chêne
authors.forename: Frederique
authors.initials: F
authors.lastname: Penault-Llorca
authors.forename: Guillaume
authors.initials: G
authors.lastname: Le Bouëdec
authors.forename: Florence
authors.initials: F
authors.lastname: Mishellany
authors.forename: Marie-Melanie
authors.initials: MM
authors.lastname: Dauplat
authors.forename: Patricia
authors.initials: P
authors.lastname: Jaffeux
authors.forename: Bruno
authors.initials: B
authors.lastname: Aublet-Cuvelier
authors.forename: Jean Luc
authors.initials: JL
authors.lastname: Pouly
authors.forename: Pierre
authors.initials: P
authors.lastname: Déchelotte
authors.forename: Jacques
authors.initials: J
authors.lastname: Dauplat
mesh_terms: D000328:Adult; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D010049:Ovarian Diseases / Q000235:genetics / Q000473:pathology* / Q000601:surgery*; D010052:Ovariectomy; D012189:Retrospective Studies