title: Quantitative differential proteome analysis in an animal model for human melanoma.
abstract: In fish of the genus Xiphophorus, different grades of pigment cell lesions from nevi to melanoma can be gained by simple crossbreeding. With this model, one can easily access tissues of different malignancies from animals with highly identical genetic background. To find protein expression differences between healthy, benign and malignant tissues, we performed 2D PAGE and DIGE and found among regulated proteins antioxidant proteins that were overexpressed with increasing malignancy.
authors.affiliation: Rudolf-Virchow-Center, DFG-Research Center for Experimental Biomedicine, University of Wurzburg, Versbacher Str. 9, 97078 Wurzburg, Germany.
authors.forename: Katrin
authors.initials: K
authors.lastname: Lokaj
authors.forename: Svenja
authors.initials: S
authors.lastname: Meierjohann
authors.forename: Claudia
authors.initials: C
authors.lastname: Schütz
authors.forename: Janka
authors.initials: J
authors.lastname: Teutschbein
authors.forename: Manfred
authors.initials: M
authors.lastname: Schartl
authors.forename: Albert
authors.initials: A
authors.lastname: Sickmann
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002471:Cell Transformation, Neoplastic; D003532:Cyprinodontiformes / Q000378:metabolism*; D015180:Electrophoresis, Gel, Two-Dimensional; D006801:Humans; D008546:Melanoma, Experimental / Q000378:metabolism*; D020543:Proteome / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D020543:Proteome