Triterpenes from Acanthopanax sessiliflorus fruits and their antiplatelet aggregation activities.
One new triterpenoid saponin and two lupane-derived triterpenes were isolated from Acanthopanax sessiliflorus fruits. The structures of the two new compounds were elucidated as 3- O-[(alpha- L-arabinopyranosyl)-(1 --> 2)]-[ beta- D-glucuronopyranosyl-6- O-methyl ester]-olean-12-ene-28-olic acid (1) and (1 R,11 alpha,22 alpha)-1,4-epoxy-11,22-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid (3) on the basis of spectral analysis, including MS, (1)H-NMR, (13)C-NMR, DEPT, HMBC, HMQC and NOESY. The structure of the other new natural product was elucidated as (1 R,11 alpha)-1,4-epoxy-11-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid (2). All these compounds showed antiplatelet aggregation activity on ADP-induced platelet aggregation.
Yang
Chunjuan
C
School of Pharmacy, Shenyang Pharmaceutical University, 110016 Shenyang, PR China.
An
Qi
Q
Xiong
Zhili
Z
Song
Yang
Y
Yu
Kai
K
Li
Famei
F
D000818:Animals; D028001:Eleutherococcus / Q000737:chemistry*; D005638:Fruit; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
C544503:(1 R,11 alpha)-1,4-epoxy-11-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid; C544502:(1 R,11 alpha,22 alpha)-1,4-epoxy-11,22-hydroxy-3,4-secolupane-20(30)-ene-3,28-dioic acid; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D012503:Saponins; D014315:Triterpenes