title: Effects of human midkine on spontaneous resorption of herniated intervertebral discs.
abstract: This study was performed in 36 rabbits to investigate the role of midkine (MK) in the resorption of herniated intervertebral discs. The L(1-2) disc was excised and immersed in one of three kinds of solution for two hours before relocation into the L4 epidural space. In the MK-treated group, the weight of relocated intervertebral discs decreased more over time than in the control group. Newly formed vessels and inflammatory cells were more frequently observed in the MK-treated group than in the control group two weeks after surgery. The degradation of matrix was more significant in the MK-treated group than in the control group four weeks after surgery. Larger areas were replaced by fibrous tissues in the MK-treated group eight weeks after surgery. Thus, MK can accelerate the resorption of the intervertebral disc relocation to the epidural space. Epidural injection of MK may contribute to the therapy of lumber disc herniation.
authors.affiliation: Department of Orthopaedics, Huzhou Central Hospital, Huzhou 313000, China. guoshun_zhou@yahoo.cn
authors.forename: Guoshun
authors.initials: G
authors.lastname: Zhou
authors.forename: Licheng
authors.initials: L
authors.lastname: Dai
authors.forename: Xuesheng
authors.initials: X
authors.lastname: Jiang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Ma
authors.forename: Jinliang
authors.initials: J
authors.lastname: Ping
authors.forename: Jianyou
authors.initials: J
authors.lastname: Li
authors.forename: Xiongfeng
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology*; D004195:Disease Models, Animal; D004824:Epidural Space / Q000601:surgery; D006801:Humans; D007403:Intervertebral Disc / Q000187:drug effects / Q000473:pathology* / Q000637:transplantation; D007405:Intervertebral Disc Displacement / Q000473:pathology* / Q000601:surgery; D008159:Lumbar Vertebrae / Q000473:pathology; D000078792:Midkine; D009389:Neovascularization, Pathologic / Q000139:chemically induced / Q000473:pathology*; D009414:Nerve Growth Factors / Q000494:pharmacology / Q000502:physiology*; D011817:Rabbits; D012075:Remission, Spontaneous
chemical_list: D016207:Cytokines; D009414:Nerve Growth Factors; D000078792:Midkine