title: Posterior fossa neoplasm and PHACES syndrome: a case report.
abstract: A 4-year-old girl with PHACES syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, cardiac anomalies/coarctation of the aorta, eye abnormalities, and sternal clefting/supraumbilical raphe) developed a cerebellar pilocytic astrocytoma 18 months after resolution of her neck, ear, and thoracic hemangiomas. Because cutaneous hemangiomas may have involuted by the time a patient is diagnosed with a central nervous system neoplasm, it seems possible that in other such patients the association may have gone unrecognized. Cerebellar pilocytic astrocytoma may be a rare manifestation of the posterior fossa malformations of PHACES.
authors.affiliation: Division of Pediatric Hematology Oncology, The University of North Carolina, Chapel Hill, NC 27599-7236, USA. kwallen@unch.unc.edu
authors.forename: Katharine E
authors.initials: KE
authors.lastname: Wallen
authors.forename: Eldad J
authors.initials: EJ
authors.lastname: Hadar
authors.forename: Victor
authors.initials: V
authors.lastname: Perry
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Bouldin
authors.forename: James
authors.initials: J
authors.lastname: Loehr
authors.forename: Julie
authors.initials: J
authors.lastname: Blatt
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology / Q000503:physiopathology; D001254:Astrocytoma / Q000209:etiology* / Q000473:pathology; D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications; D006391:Hemangioma / Q000150:complications* / Q000151:congenital; D006801:Humans; D015192:Infratentorial Neoplasms / Q000209:etiology* / Q000473:pathology; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D013577:Syndrome