[Expression of OX40 and Bcl-2 in allergic rhinitis].
OBJECTIVE
To investigate the role of OX40 and Bcl-2 in allergic rhinitis(AR).


METHODS
Twenty-three subjects of allergic rhinitis as experimental group were collected and 20 subjects of deflection of nasal septum as control group. OX40 and Bcl-2 expression were examined in biopsy specimens of AR patients and nasal septum patients by immunohistochemistry respectively. The relationship between OX40 and Bcl-2 expression was analyzed.


RESULTS
OX40 and Bcl-2 expression increased in the AR patients. There were positive staining not only in CD4+ T cells,but also in vascular endothelial cell, epithelial cell and glandular epithelium cell (P < 0.01). Compared with control group, the expression of OX40 (0.239 4 +/- 0.033 5) and Bcl-2 (0.237 3 +/- 0.042 1) were significantly higher than that in control group (P < 0.01). The OX40 expression was closely related to Bcl-2 expression (r = 0.869 0, P < 0.05).


CONCLUSIONS
The abnormal expression of costimulatory molecule OX40 is well evidenced in AR. Bcl-2 expression is likely mediated by OX40 signal pathway.
Zhao
Jiandong
J
Department of Otolaryngology, Second Affiliated Hospital, Shandong University, Jinan 270012, China. zhaojd.jack@yahoo.com.cn
Li
Wei
W
Wang
Yanjun
Y
Chen
Xuemei
X
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism* / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D053262:Receptors, OX40 / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
D019253:Proto-Oncogene Proteins c-bcl-2; D053262:Receptors, OX40; C505716:TNFRSF4 protein, human