Mouse studies of SARS coronavirus-specific immune responses to recombinant replication-defective adenovirus expressing SARS coronavirus N protein.
1. A recombinant adenovirus encoding SARS coronavirus(SARS-CoV) nucleocapsid protein (rAd-N) was constructed. 2. The ability of the rAd-N to induce anti-SARS-CoV N antibody production and cellular immune responses was evaluated in an HLA-A2.1/Kb transgenic mouse model.
Sin
F W Y
FW
Department of Biology, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong SAR, China.
Cheng
S C S
SC
Chan
K T
KT
Meng
L
L
Yu
J
J
Xie
Y
Y
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D000917:Antibody Formation; D000086462:Coronavirus Nucleocapsid Proteins; D005260:Female; D005822:Genetic Vectors; D015789:HLA-A2 Antigen / Q000235:genetics*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008822:Mice, Transgenic; D019590:Nucleocapsid Proteins / Q000235:genetics / Q000276:immunology*; D045473:Severe acute respiratory syndrome-related coronavirus / Q000235:genetics / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000086462:Coronavirus Nucleocapsid Proteins; D015789:HLA-A2 Antigen; D019590:Nucleocapsid Proteins; D014765:Viral Vaccines