title: Regional pulmonary blood flow: Comparison of dynamic contrast-enhanced MR perfusion and phase-contrast MR.
abstract: Regional pulmonary blood flow can be assessed using both dynamic contrast-enhanced (DCE) MR and phase-contrast (PC) MR. These methods provide somewhat complementary information: DCE MR can assess flow over the entire lung while PC MR can detect rapid changes in flow to a targeted region. Although both methods are considered accurate, one may be more feasible than the other depending on pathology, patient condition, and availability of an intravenous route. The objective of this study was to establish a consensus between the two methods by comparing paired DCE MR and PC MR measurements of relative blood flow in Yorkshire piglets (N = 5, age = 7 days, weight = 3.3 +/- 0.6 kg) under various physiological states including regional lung collapse. A strong correlation (R(2) = 0.71, P < 0.01) was observed between the methods. In conclusion, DCE MR and PC MR provide a consistent measure of changes in regional pulmonary blood flow.
authors.affiliation: Department of Medical Biophysics, University of Toronto and Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: Joshua F P
authors.initials: JF
authors.lastname: van Amerom
authors.forename: Logi
authors.initials: L
authors.lastname: Vidarsson
authors.forename: Shengping
authors.initials: S
authors.lastname: Wu
authors.forename: Rogerio
authors.initials: R
authors.lastname: Tessler
authors.forename: Shi-Joon
authors.initials: SJ
authors.lastname: Yoo
authors.forename: Jaques
authors.initials: J
authors.lastname: Belik
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Macgowan
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D003287:Contrast Media; D019786:Gadolinium DTPA; D018810:Magnetic Resonance Angiography / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D011651:Pulmonary Artery / Q000503:physiopathology*; D001261:Pulmonary Atelectasis / Q000175:diagnosis* / Q000503:physiopathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013552:Swine
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA