Heat shock protein 27 in neuronal survival and neurite outgrowth.
The small heat shock protein 27 (Hsp27) is well documented to promote neuronal survival in neurodegenerative diseases and following nerve injury. It can directly inhibit apoptotic pathways, and as a chaperone it can ameliorate the toxic effects of misfolded proteins. More recently, Hsp27 has been implicated to also play a role in neurite outgrowth. Thus, Hsp27 is situated at the intersection of neuronal survival and differentiation and, as such, it has dual potential as a key therapeutic target for neuroregeneration.
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Danielle E
DE
Cell Death and Survival Group, Department of Biochemistry, School of Natural Sciences, National University of Ireland, Galway, Ireland.
Gorman
Adrienne M
AM
D017209:Apoptosis; D002470:Cell Survival; D055551:HSP27 Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D016501:Neurites / Q000502:physiology*; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D009474:Neurons / Q000502:physiology*
D055551:HSP27 Heat-Shock Proteins