title: Multiple sclerosis-associated retroviral agent (MSRV)-stimulated cytokine production in patients with relapsing-remitting multiple sclerosis.
abstract: BACKGROUND
  Human endogenous retroviruses are suggested to play a pathogenic role in multiple sclerosis (MS); one of such retroviruses, the MS-associated retroviral agent (MSRV) has repeatedly been isolated in MS patients.
  
  
  OBJECTIVE
  We analyzed cytokine profiles in MSRV envelope protein (MSRV ENV-SU)-stimulated peripheral blood mononuclear cells of 30 relapsing-remitting MS patients with either acute (AMS) (n = 13) or stable (SMS) (n = 17) disease. Results suggest that MSRV ENV-SU induces the production of inflammatory cytokines, including tumor necrosis factor-alpha (P < 0.05) and interferon-gamma (P < 0.004) in AMS patients and of interleukin-10 (P < 0.05), an inflammation-dampening cytokine, in SMS individuals.
  
  
  CONCLUSIONS
  These data strengthen the hypothesis indicating that MSRV could be involved in the pathogenesis of MS.
authors.affiliation: Laboratory of Molecular Medicine and Biotechnology, Don C. Gnocchi ONLUS Foundation IRCCS, Via Capecelatro, 66, Milano 20148, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Saresella
authors.forename: A
authors.initials: A
authors.lastname: Rolland
authors.forename: I
authors.initials: I
authors.lastname: Marventano
authors.forename: R
authors.initials: R
authors.lastname: Cavarretta
authors.forename: D
authors.initials: D
authors.lastname: Caputo
authors.forename: P
authors.initials: P
authors.lastname: Marche
authors.forename: H
authors.initials: H
authors.lastname: Perron
authors.forename: M
authors.initials: M
authors.lastname: Clerici
mesh_terms: D000208:Acute Disease; D000328:Adult; D017252:CD3 Complex / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism*; D020077:Endogenous Retroviruses / Q000276:immunology*; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D016753:Interleukin-10 / Q000378:metabolism; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008297:Male; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000276:immunology* / Q000821:virology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D055815:Young Adult
chemical_list: D017252:CD3 Complex; D016207:Cytokines; C508609:IL10 protein, human; D018950:Lipopolysaccharide Receptors; D016693:Receptors, Antigen, T-Cell, alpha-beta; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma