title: Factors associated with HIV-1 proviral DNA loads in patients with undetectable plasma RNA load.
abstract: To evaluate factors associated with human immunodeficiency virus type 1 (HIV-1) proviral DNA load, we conducted a cross-sectional study of 36 chronically HIV-1-infected individuals with undetectable plasma viral RNA. We used real-time polymerase chain reaction to determine the number of HIV-1 proviral DNA copies per 10(6) peripheral blood mononuclear cells. The mean level of plasma viral RNA when the CD4+ T cell count was above 500 cells/microL without highly active antiretroviral therapy (HAART) was significantly associated with proviral DNA load at the time of undetectable plasma HIV RNA with HAART. Strategies to reduce the level of plasma viral RNA when patients' CD4+ T cell counts are above 500 cells/microL without HAART could help reduce HIV-1 proviral DNA load.
authors.affiliation: Department of Internal Medicine and AIDS Research Institute, BK21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Jun Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Young Goo
authors.initials: YG
authors.lastname: Song
authors.forename: Young Hwa
authors.initials: YH
authors.lastname: Kim
authors.forename: Chang Oh
authors.initials: CO
authors.lastname: Kim
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Bum Sik
authors.initials: BS
authors.lastname: Chin
authors.forename: Sang Hoon
authors.initials: SH
authors.lastname: Han
authors.forename: Suk Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Han Sung
authors.initials: HS
authors.lastname: Lee
authors.forename: Su Jin
authors.initials: SJ
authors.lastname: Jeong
authors.forename: Heekyoung
authors.initials: H
authors.lastname: Choi
authors.forename: June Myung
authors.initials: JM
authors.lastname: Kim
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D003430:Cross-Sectional Studies; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011533:Proviruses / Q000235:genetics*; D012367:RNA, Viral / Q000097:blood
chemical_list: D019380:Anti-HIV Agents; D004279:DNA, Viral; D012367:RNA, Viral