title: Breast cancer quality control.
abstract: Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth, suggesting a new role for quality-control mechanisms in suppressing cells with malignant potential.
authors.affiliation: Division of Cardiology and Carolina Cardiovascular Biology Center, University of North Carolina at Chapel Hill, 8200 Medical Biomolecular Research Building, Chapel Hill, North Carolina 27599-7126, USA. cpatters@med.unc.edu
authors.forename: Cam
authors.initials: C
authors.lastname: Patterson
authors.forename: Sarah
authors.initials: S
authors.lastname: Ronnebaum
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D048708:Cell Growth Processes; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D051548:Histone Acetyltransferases / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D056921:Nuclear Receptor Coactivator 3; D015534:Trans-Activators / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*; D023041:Xenograft Model Antitumor Assays
chemical_list: D015534:Trans-Activators; D051548:Histone Acetyltransferases; C538866:NCOA3 protein, human; C538867:Ncoa3 protein, mouse; D056921:Nuclear Receptor Coactivator 3; C467728:STUB1 protein, human; D044767:Ubiquitin-Protein Ligases