title: The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches.
abstract: The effects of terpenes on the release and permeation of ofloxacin and lidocaine from moisture-activated composite patches were investigated. Ofloxacin without enhancers showed very low permeation rate (0.58 microg/cm(2)/hr), and the addition of cineole enhanced the permeation flux 14.1-times; /-menthol and d-limonene increased it 4.7- and 3.5-times, respectively. The highest permeation flux (77.7 +/- 25.3 microg/cm(2)/hr) of lidocaine from the composite patches was also achieved when cineole at the concentration of 0.33% in the gel base was added. /-Menthol also revealed enhancing effect on the permeation of lidocaine; however, d-limonene failed to increase the permeation rate of lidocaine. In conclusion, for effective moisture- activated patches containing lidocaine and ofloxacin, cineole could be used as an effective and safe enhancer.
authors.affiliation: College of Pharmacy, Dongduk Women's University, Seoul, Korea.
authors.forename: Yeon Hwa
authors.initials: YH
authors.lastname: Song
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Gwak
authors.forename: In Koo
authors.initials: IK
authors.lastname: Chun
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000180:Acrylic Resins / Q000737:chemistry; D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology*; D000279:Administration, Cutaneous; D000818:Animals; D001682:Biological Availability; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D003511:Cyclohexanols / Q000494:pharmacology; D053138:Cyclohexenes / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D000077591:Eucalyptol; D005079:Excipients / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D066298:In Vitro Techniques; D008012:Lidocaine / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D000077222:Limonene; D008297:Male; D008298:Maleates / Q000737:chemistry; D008610:Menthol / Q000494:pharmacology; D051379:Mice; D008812:Mice, Hairless; D039821:Monoterpenes / Q000494:pharmacology; D015242:Ofloxacin / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D011095:Polyethylenes / Q000737:chemistry; D011136:Polysorbates / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects*; D013729:Terpenes / Q000494:pharmacology*; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D000180:Acrylic Resins; D000277:Adjuvants, Pharmaceutic; D003511:Cyclohexanols; D053138:Cyclohexenes; D005079:Excipients; D020100:Hydrogels; D008298:Maleates; D039821:Monoterpenes; D011095:Polyethylenes; D011136:Polysorbates; D013729:Terpenes; D047392:beta-Cyclodextrins; C479038:carbomer; D008610:Menthol; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002482:Cellulose; C002283:hydroxyethylcellulose; C043105:poly(methyl vinyl ether-co-maleic anhydride); D008012:Lidocaine; D000077222:Limonene; D015242:Ofloxacin; D000077591:Eucalyptol