title: Flavonoid glucosides from the hairy roots of Catharanthus roseus.
abstract: Four new flavonoid glucosides, 3',4'-di-O-methylquercetin-7-O-[(4''-->13''')-2''',6''',10''',14'''-tetramethylhexadec-13'''-ol-14'''-enyl]-beta-D-glucopyranoside (1), 4'-O-methylkaempferol-3-O-[(4''-->13''')- 2''',6''',10''',14'''-tetramethylhexadecan-13'''-olyl]-beta-D-glucopyranoside (2), 3',4'-di-O-methylbutin-7-O-[(6''-->1''')-3''',11'''-dimethyl-7'''-methylenedodeca-3''',10'''-dienyl]-beta-D-glucopyranoside (3), and 4'-O-methylbutin-7-O-[(6''-->1''')-3''',11'''-dimethyl-7'''-hydroxymethylenedodecanyl]-beta-D-glucopyranoside (4), along with the three known compounds were isolated from the methanol extract of Catharanthus roseus hairy roots. Their structures were elucidated spectroscopically. The new flavonoid glucosides inhibited both MMP-9 activity and TNF-alpha production in THP-1 cells treated with lipopolysaccharide.
authors.affiliation: Department of Applied Life Science, Konkuk University, Seoul, Korea.
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Ateeque
authors.initials: A
authors.lastname: Ahmad
authors.forename: Mohd
authors.initials: M
authors.lastname: Ali
authors.forename: Oh-Kyu
authors.initials: OK
authors.lastname: Lee
authors.forename: Min-Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Jung-Hee
authors.initials: JH
authors.lastname: Kim
authors.forename: Do-Young
authors.initials: DY
authors.lastname: Yoon
authors.forename: Christie A M
authors.initials: CA
authors.lastname: Peebles
authors.forename: Ka Yiu
authors.initials: KY
authors.lastname: San
mesh_terms: D000818:Animals; D030008:Catharanthus / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D061965:Matrix Metalloproteinase Inhibitors; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D005419:Flavonoids; D005960:Glucosides; D008070:Lipopolysaccharides; D061965:Matrix Metalloproteinase Inhibitors; D014409:Tumor Necrosis Factor-alpha