title: Light-regulated activation of cellular signaling by gold nanoparticles that capture and release amines.
abstract: A photoresponsive nanocarrier for amines based on gold nanoparticles (GNPs) having a photocleavable succinimidyl ester has been developed. It offers a useful platform for the synthesis of caged compounds. Using the GNPs, we have developed caged histamine for the first time and applied it to evoke intracellular signaling by controlled near-UV irradiation. The present work will allow for new possibilities in studies of inter- and intracellular signaling networks.
authors.affiliation: World Premier International Research Center Initiative, International Center for Materials Nanoarchitectonics, National Institute for Materials Science (NIMS), 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. nakanishi.jun@nims.go.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Nakanishi
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Nakayama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shimizu
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Ishida
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Horiike
mesh_terms: D000588:Amines / Q000737:chemistry*; D006046:Gold; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry*; D012107:Research Design; D015398:Signal Transduction / Q000528:radiation effects*
chemical_list: D000588:Amines; D006046:Gold