title: [Case of extra-hepatic lymph node metastasis of hepatocellular carcinoma with no evident sign of intra-hepatic recurrence].
abstract: A 73-year-old man with chronic hepatitis C was Successfully treated for hepatocellular carcinoma (HCC) by localized treatment. During the follow-up period, abdominal computed tomography (CT) revealed no HCC recurrence in the liver. However, 9 months after the treatment, abdominal lymph nodes appeared enlarged on CT. Laparoscopic biopsy of the lymph nodes showed that the lesion was HCC, and TS-1/cisplatin chemotherapy was performed. However, extra-hepatic lymph nodes rapidly grew, leading to obstructive jaundice and finally death 10 months after of HCC metastasis. Although abdominal lymph node metastasis of HCC has been widely considered to be rare, the confirmation of effective therapy is awaited because histological studies have suggested that this pathologic lesion may occur more often than expected.
authors.affiliation: The Third Department of Internal Medicine, Niigata University School of Medicine, Japan. m0riz0u@extra.ocn.ne.jp
authors.forename: Shinichi
authors.initials: S
authors.lastname: Morita
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Matsuda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Oshima
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kubota
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kawauchi
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Minoru
authors.initials: M
authors.lastname: Nomoto
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Aoyagi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000556:secondary* / Q000628:therapy; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D017809:Fatal Outcome; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D009364:Neoplasm Recurrence, Local; D017640:Silicates / Q000008:administration & dosage; D014025:Titanium / Q000008:administration & dosage
chemical_list: D017640:Silicates; C103828:titanium silicide; D014025:Titanium; D002945:Cisplatin