title: The impact of extratemporal epilepsy surgery on quality of life.
abstract: Quality of life (QOL) with respect to seizure outcome, cognitive performance, and depressive symptoms was analyzed in 21 adult patients undergoing extratemporal epilepsy surgery (EXTLE). The Subjective Handicap of Epilepsy questionnaire was administered before and 1 year after surgery. Additionally, cognitive performance, depressive symptoms (Beck Depression Inventory), and seizure frequency were assessed. After surgery, seizure frequency decreased and various aspects of QOL significantly improved. Improvements in the domain of Work and Activities correlated with a reduction in complex partial seizure frequency. Alterations in the subscale change correlated with a decrease in simple partial seizure frequency. The present results provide detailed evidence that patients with extratemporal epilepsy benefit from epilepsy surgery.
authors.affiliation: Epilepsy Center, University Hospital Freiburg, Breisacher Strasse 64, Freiburg, Germany. Franziska.Buschmann@uniklinik-freiburg.de
authors.forename: F
authors.initials: F
authors.lastname: Buschmann
authors.forename: K
authors.initials: K
authors.lastname: Wagner
authors.forename: B
authors.initials: B
authors.lastname: Metternich
authors.forename: S
authors.initials: S
authors.lastname: Biethahn
authors.forename: J
authors.initials: J
authors.lastname: Zentner
authors.forename: A
authors.initials: A
authors.lastname: Schulze-Bonhage
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004828:Epilepsies, Partial / Q000523:psychology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000379:methods; D011569:Psychiatric Status Rating Scales; D011788:Quality of Life; D013223:Statistics as Topic; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult