title: Atypical thyrotropin-secreting pituitary microadenoma revealed by severe osteoporosis in a young man.
abstract: For 10 years, a young man was followed for a severe osteoporosis associated with a considerable reduction in height and a massive weight loss. The constant increase of signs of tissue impregnation with thyroid hormones and the molar ratios of alpha-TSH suggested an inappropriate secretion of thyrotropin. Magnetic resonance imaging finally revealed a thyrotropic microadenoma of the pituitary gland. This case gives some new additional information on thyrotropin-induced osteoporosis. To our knowledge such a case has never been reported in the literature.
authors.affiliation: Service d'Endocrinologie-Diabétologie, Hôpital E. Herriot, Hospices Civils de Lyon, Lyon, 69003, France. alexis.de.rougemont@sante.univ-lyon1.fr
authors.forename: Alexis
authors.initials: A
authors.lastname: de Rougemont
authors.forename: Marie-Gabrielle
authors.initials: MG
authors.lastname: Mourot
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Riou
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001827:Body Height; D001835:Body Weight; D015519:Bone Density / Q000187:drug effects; D002118:Calcium / Q000097:blood / Q000652:urine; D002231:Carbimazole / Q000627:therapeutic use; D004164:Diphosphonates / Q000494:pharmacology / Q000627:therapeutic use; D015292:Glycoprotein Hormones, alpha Subunit / Q000097:blood / Q000378:metabolism; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D006980:Hyperthyroidism / Q000097:blood / Q000150:complications / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008297:Male; D015282:Octreotide / Q000627:therapeutic use; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000097:blood / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism*; D010710:Phosphates / Q000097:blood; D010902:Pituitary Gland / Q000473:pathology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D004164:Diphosphonates; D015292:Glycoprotein Hormones, alpha Subunit; D010710:Phosphates; D014284:Triiodothyronine; D015675:Osteocalcin; D002231:Carbimazole; D013972:Thyrotropin; D000469:Alkaline Phosphatase; D013974:Thyroxine; D006909:Hydroxyproline; D015282:Octreotide; D002118:Calcium