Nicolau syndrome induced by intramuscular vitamin K in a premature newborn.
BACKGROUND
Nicolau syndrome (NS), also known as livedo-like dermatitis or embolia cutis medicamentosa, is a very rare complication of intramuscular and intraarticular injection of various drugs.


METHODS
We herein report a case of NS developing approximately 2 h after the intramuscular administration of vitamin K1 in an extremely low birth weight premature newborn. To our knowledge, this patient is the youngest case suffering from such a livedoid skin necrosis and the first case of neonatal NS developing due to intramuscular administration of vitamin K1.
Koklu
Esad
E
Division of Neonatology, Department of Pediatrics, Gulhane Military Medical Academy, Ankara, Turkey. esadsena@yahoo.com.tr
Sarici
Serdar Umit
SU
Altun
Demet
D
Erdeve
Omer
O
D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced*; D007273:Injections, Intramuscular; D008297:Male; D012867:Skin / Q000187:drug effects; D017445:Skin Diseases, Vascular / Q000139:chemically induced*; D013577:Syndrome; D014805:Vitamin B 12 / Q000008:administration & dosage / Q000009:adverse effects*; D014803:Vitamin B Complex / Q000008:administration & dosage / Q000009:adverse effects*; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control
D014803:Vitamin B Complex; D014805:Vitamin B 12