title: Update on the natural history and systemic treatment of psoriasis.
abstract: The onset of psoriatic disease and its associated comorbidities involves the interplay among a myriad of genetic and environmental risk factors. As we gain further insight into the immunopathogenesis of psoriasis, we hope it will provide the basis for the development of safer, more efficacious, and more durable therapeutics in the future. Given its enormous toll on patient health and quality of life, steps should be taken to prevent or decrease the risk for psoriasis-associated comorbidities through behavior modification and use of preventative health screenings and treatments. Future studies will need to be performed to determine if successful treatment of psoriasis will lead to a decreased risk for developing psoriasis-associated comorbidities over time.
authors.affiliation: Florida State University College of Medicine/Dermatology Associates of Tallahassee, 1714 Mahan Center Boulevard, Tallahassee, FL 32308, USA.
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Richardson
authors.forename: Joel M
authors.initials: JM
authors.lastname: Gelfand
mesh_terms: D003879:Dermatologic Agents / Q000627:therapeutic use; D006801:Humans; D011565:Psoriasis / Q000188:drug therapy*; D012307:Risk Factors; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D003879:Dermatologic Agents; D014409:Tumor Necrosis Factor-alpha