Changes in lipid distribution during aging and its modulation by calorie restriction.
Adipogenesis and ectopic lipid accumulation during aging have a great impact on the aging process and the pathogenesis of chronic diseases with age. However, at present, information on the age-related molecular changes in lipid redistribution patterns and their potential nutritional interventions is sparse. We investigated the mechanism underlying age-related lipid redistribution and its modulation using 5-, 17-, and 24-month-old male Fischer 344 rats fed ad libitum (AL) or a 3-week-long CR (40% less than AL) diet. Results revealed that the activities of adipogenic transcription factors were decreased in the white adipose tissue (WAT) of aged AL rats. In contrast, the skeletal muscle of aged AL rats showed increased fat accumulation through decreased carnitine palmitoyltransferase-1 activity, which was blunted by short-term CR. This study suggests an age-related shift in lipid distribution by reducing the adipogenesis of WAT while increasing intramyocellular lipid accumulation, and that CR can modulate age-related adipogenesis and ectopic lipid accumulation.
Kim
Ji Young
JY
Department of Pharmacy, College of Pharmacy, Pusan National University, Gumjung-gu, Busan, 609-735, Korea.
Kim
Dae Hyun
DH
Choi
Jaehun
J
Park
Jin-Kyu
JK
Jeong
Kyu-Shik
KS
Leeuwenburgh
Christiaan
C
Yu
Byung Pal
BP
Chung
Hae Young
HY