Interfacing glycosylated carbon-nanotube-network devices with living cells to detect dynamic secretion of biomolecules.
A sense of cell-being: Single-walled carbon nanotubes (SWNTs) are functionalized with bioactive monosaccharides to enable their use as biosensors. The glycosylated nanotube network is biocompatible and can interface with living cells (see scheme) to electronically detect biomolecular release with high temporal resolution and high sensitivity.
Sudibya
Herry Gunadi
HG
School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Singapore.
Ma
Jimei
J
Dong
Xiaochen
X
Ng
Simon
S
Li
Lain-Jong
LJ
Liu
Xue-Wei
XW
Chen
Peng
P
D000818:Animals; D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D006031:Glycosylation; D018625:Microscopy, Atomic Force; D009005:Monosaccharides / Q000138:chemical synthesis / Q000737:chemistry; D037742:Nanotubes, Carbon / Q000737:chemistry*; D016716:PC12 Cells; D051381:Rats
D009005:Monosaccharides; D037742:Nanotubes, Carbon