title: Evaluation of a computerized system for mechanical ventilation of infants.
abstract: OBJECTIVE
  To evaluate a computerized system for mechanical ventilation of infants.
  
  
  METHODS
  FLEX is a computerized system that includes the features of a patented mode known as adaptive-support ventilation (ASV). In addition, it has many other features including adjustment of positive end-expiratory pressure (PEEP), fraction of inspired oxygen (F(IO2)), minute ventilation, and control of weaning. It is used as an open-loop decision support system or as a closed-loop technique. Blood gas and ventilation data were collected from 12 infants in the neonatal intensive care at baseline and at the next round of evaluation. This data were input to open-loop version of FLEX. The system recommendations were compared to clinical determinations.
  
  
  RESULTS
  FLEX recommended values for ventilation were on the average within 25% and 16.5% of the measured values at baseline and at the next round of evaluation, respectively. For F(IO2) and PEEP, FLEX recommended values were in general agreement with the clinical settings. FLEX recommendations for weaning were the same as the clinical determinations 50% of the time at baseline and 55% of the time at the next round of evaluation. FLEX did not recommend weaning for infants with weak spontaneous breathing effort or those who showed signs of dyspnea.
  
  
  CONCLUSIONS
  A computerized system for mechanical ventilation is evaluated for treatment of infants. The results of the study show that the system has good potential for use in neonatal ventilatory care. Further refinements can be made in the system for very low-birth-weight infants.
authors.affiliation: California State University, Fullerton, 800 N. State College Boulevard, Fullerton, CA 92831, USA. ftehrani@fullerton.edu
authors.forename: Fleur T
authors.initials: FT
authors.lastname: Tehrani
authors.forename: Soraya
authors.initials: S
authors.lastname: Abbasi
mesh_terms: D000465:Algorithms; D001784:Blood Gas Analysis; D003199:Computer Systems; D005260:Female; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D010101:Oxygen Consumption / Q000502:physiology; D011175:Positive-Pressure Respiration; D012121:Respiration, Artificial / Q000295:instrumentation* / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology / Q000628:therapy*; D015656:Respiratory Mechanics / Q000502:physiology; D013990:Tidal Volume