title: An examination of subjective response to alcohol in African Americans.
abstract: OBJECTIVE
  Alcohol response is a widely studied risk factor for heavy drinking behavior and alcohol-use disorders. This study examined acute subjective response to alcohol as a predictor of drinking behavior, alcohol-related problems, and family history of alcoholism in African Americans. The convergent validity of self-reported response to alcohol (Self-Rating of the Effects of Alcohol scale [SRE]) in an African-American sample was also examined.
  
  
  METHODS
  One hundred and three African-American young adults participated in an alcohol-challenge study, receiving a moderate dose of alcohol (0.72 g/kg alcohol for men, 0.65 g/kg for women). Breath alcohol concentration and subjective response to alcohol were assessed before beverage consumption, in 15-minute intervals for the first hour following consumption, and in 30-minute intervals thereafter.
  
  
  RESULTS
  Latent variable growth models indicated that experiencing increased acute stimulation from alcohol was related to past-month drinking behavior and alcohol-related problems. Regression analyses indicated that the SRE was related to drinking behavior, alcohol-related problems, having an alcohol-use disorder, and a family history of alcoholism. The SRE was not related to either sedation or stimulation following alcohol administration.
  
  
  CONCLUSIONS
  Results support alcohol response as a marker of risk for increased drinking behavior and alcohol-related problems in African Americans. Further research is required to directly compare African-American and white response to alcohol within an alcohol-challenge paradigm.
authors.affiliation: Department of Psychological Sciences, 210 McAlester Hall, University of Missouri, Columbia, Missouri 65211, USA.
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Pedersen
authors.forename: Denis M
authors.initials: DM
authors.lastname: McCarthy
mesh_terms: D000328:Adult; D001741:Black or African American / Q000523:psychology*; D000428:Alcohol Drinking / Q000208:ethnology* / Q000523:psychology*; D019973:Alcohol-Related Disorders / Q000208:ethnology; D001944:Breath Tests; D000431:Ethanol / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors; D012647:Self-Assessment
chemical_list: D000431:Ethanol