A radical bailout strategy for cancer stem cells.
In a recent issue of Nature, Diehn et al. (2009) demonstrate that breast cancer stem cells (CSCs) maintain lower levels of reactive oxygen species (ROS) than their nontumorigenic counterparts. Their studies provide a link between the management of ROS by CSCs and enhanced tumor radioresistance.
Tothova
Zuzana
Z
Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. zuzana_tothova@hms.harvard.edu
Gilliland
D Gary
DG
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism*; D049109:Cell Proliferation; D051379:Mice; D009364:Neoplasm Recurrence, Local / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D011836:Radiation Tolerance / Q000502:physiology*; D011839:Radiation, Ionizing; D017382:Reactive Oxygen Species / Q000378:metabolism*
D017382:Reactive Oxygen Species