Four-year clinical update from the American Society of Breast Surgeons MammoSite brachytherapy trial.
BACKGROUND
We present a 4-year update on the efficacy, cosmetic results, and complications of MammoSite breast brachytherapy in patients enrolled in the American Society of Breast Surgeons registry trial.


METHODS
A total of 1,449 breasts in 1,440 patients with early stage breast cancer undergoing breast-conserving therapy were treated with adjuvant, accelerated partial breast irradiation (APBI) (34 Gy in 3.4-Gy fractions) delivered with the MammoSite device. The median follow-up period for the entire group was 36.1 months.


RESULTS
The 3-year actuarial rate of ipsilateral breast tumor recurrence was 2.15%. The 3-year actuarial rate of axillary recurrence was .36%. Complication rates were as follows: infection, 9.5%; seroma, 26.8% (symptomatic seroma, 12.7%); and fat necrosis, 2.0%. The percentages of breasts with good or excellent cosmetic results were as follows: 12 months, 95%; 24 months, 94%; 36 months, 94%; and 48 months, 91%.


CONCLUSIONS
Locoregional control, complications, and cosmetic outcomes from MammoSite APBI at the 4-year update are acceptable and similar to results seen with other forms of APBI.
Nelson
Jonathan C
JC
Department of Surgical Oncology, The University of Texas MD Anderson, Cancer Center, Houston, TX 77030, USA.
Beitsch
Peter D
PD
Vicini
Frank A
FA
Quiet
Coral A
CA
Garcia
Delia
D
Snider
Howard C
HC
Gittleman
Mark A
MA
Zannis
Victor J
VJ
Whitworth
Pat W
PW
Fine
Richard E
RE
Keleher
Angela J
AJ
Kuerer
Henry M
HM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000295:instrumentation*; D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D011446:Prospective Studies; D011879:Radiotherapy Dosage / Q000592:standards; D012307:Risk Factors; D012955:Societies, Medical; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology