title: Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histological and immunohistochemical features of 3 cases.
abstract: This report describes the histological and immunohistochemical characteristics of 3 cases of nerve sheath myxoma (NSM)/neurothekeoma arising in the oral cavity. Histopathologically, 3 distinct variants were observed based on the amount of myxoid matrix: classic/hypocellular, cellular, and mixed types. Immunohistochemically, all types expressed strong immunoreactivity to S-100 protein (3/3), NSE (neuron-specific enolase) (3/3), and NGFR (nerve growth factor receptor) (3/3), whereas all cases were negative for SMA (smooth muscle actin) and FVIII. The number of Ki-67 positive cells was less than 5% in all lesions confirming the slow growing characteristics of NSM. The results suggest that NSMs of the oral cavity are true peripheral nerve sheath tumors and show close relationship to schwannoma.
authors.affiliation: Department of Diagnostic Oral Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. maimai.dlab@tmd.ac.jp
authors.forename: Mai
authors.initials: M
authors.lastname: Nishioka
authors.forename: Rodelio L
authors.initials: RL
authors.lastname: Aguirre
authors.forename: Ayataka
authors.initials: A
authors.lastname: Ishikawa
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Nagumo
authors.forename: Li-Hong
authors.initials: LH
authors.lastname: Wang
authors.forename: Norihiko
authors.initials: N
authors.lastname: Okada
mesh_terms: D002610:Cheek / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000473:pathology*; D018321:Neurothekeoma / Q000737:chemistry / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D017475:Receptors, Nerve Growth Factor / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
chemical_list: D017475:Receptors, Nerve Growth Factor; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase