title: The role of recombinant activated Factor VII in major obstetric haemorrhage: the Farnborough experience.
abstract: Major obstetric haemorrhage is one of the commonest causes of maternal mortality and morbidity worldwide. It may result in coagulopathy and diffuse pelvic or vaginal bleeding. Correction of coagulopathy when administering Factor VII may be crucial to the management of selected cases. We report the use of recombinant activated factor in three cases of massive obstetric haemorrhage. Prolonged international normalised ratio, activated partial thromboplastin time, and reduced fibrinogen were the trigger to use rFVIIa. It was effective to halt the process of coagulopathy, secure haemostasis and improve laboratory parameters in all three patients. We review the relevant literature and discuss its indications, the potential benefits and possible complications. Recombinant activated Factor VII is a potential haemostatic agent in massive obstetric haemorrhage. Its successful use has been reported in post-surgical bleeding and consumptive coagulopathy. It may abolish the need for hysterectomy, which has a devastating effect on the patient future fertility and psychological well-being.
authors.affiliation: Princess Royal University Hospital, Orpington, London, UK. ihab@doctors.org.uk
authors.forename: I
authors.initials: I
authors.lastname: Wissa
authors.forename: E
authors.initials: E
authors.lastname: Ebeid
authors.forename: S
authors.initials: S
authors.lastname: El-Shawarby
authors.forename: S
authors.initials: S
authors.lastname: Chandakas
authors.forename: T
authors.initials: T
authors.lastname: Kamal
authors.forename: N
authors.initials: N
authors.lastname: Hill
mesh_terms: D000328:Adult; D002585:Cesarean Section / Q000009:adverse effects*; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D006473:Postpartum Hemorrhage / Q000188:drug therapy*; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D006490:Hemostatics; D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa