[Distribution of hepatitis B virus genotypes and subgenotypes among chronically infected patients in Xinjiang Uighur.].
OBJECTIVE
To investigate the distribution of Hepatitis B virus genotypes and subgenotypes among patients with chronic hepatitis B in Xinjiang Uighur.


METHODS
The HBV genotypes and subgenotypes were analyzed by PCR-restriction fragment length polymorphism in 109 patients with chronic hepatitis B.


RESULTS
Two HBV genotypes, genotype C (45.9%) and genotype C/D (29.4%) were prevalent, genotype B (8.3%) and genotype D (16.5%) were also found in Xinjiang Uighur. Genotype C had two subgenotypes, C1 (54%) and C2 (46%). Genotype B had only one subgenotype, i.e. Ba. The subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.


CONCLUSIONS
In Uygurs, the most common HBV genotypes were C and C/D, and the subgenotype C2 was associated with cirrhosis and hepatocellular carcinoma.
Sun
Xiao-Feng
XF
Department of Infectious Diseases, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
Wen
Shu-Juan
SJ
Li
Hui
H
Hou
Jin-Lin
JL
Zhang
Yue-Xin
YX
Wang
Zhan-Hui
ZH
Zheng
Yu-Jian
YJ
D006528:Carcinoma, Hepatocellular / Q000821:virology; D005838:Genotype; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000821:virology; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology