Imaging oncogene expression.
This review briefly outlines the importance of molecular imaging, particularly imaging of endogenous gene expression for noninvasive genetic analysis of radiographic masses. The concept of antisense imaging agents and the advantages and challenges in the development of hybridization probes for in vivo imaging are described. An overview of the investigations on oncogene expression imaging is given. Finally, the need for further improvement in antisense-based imaging agents and directions to improve oncogene mRNA targeting is stated.
Mukherjee
Archana
A
Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Archana.Mukherjee@jefferson.edu
Wickstrom
Eric
E
Thakur
Mathew L
ML
D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D015336:Molecular Probe Techniques / Q000639:trends; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D009857:Oncogenes; D049268:Positron-Emission Tomography / Q000379:methods*; D011868:Radioisotopes / Q000493:pharmacokinetics*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D011868:Radioisotopes