Effects of acetate on lipid metabolism in muscles and adipose tissues of type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
We have reported that orally administrated acetate contributed to suppression of lipogenesis in the liver and to reduction of lipid accumulation in the adipose tissue of Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The aim of this study was to investigate the effect of acetate on skeletal muscle and adipose tissues. Treatment with acetate showed a higher rate of oxygen consumption and a smaller size of lipid droplets in white adipose and brown adipose tissues. An analysis by Northern blotting revealed that the transcripts of myoglobin and Glut4 genes in the abdominal muscle of the OLETF rats were increased by acetate treatment, while the transcripts of lipolytic genes increased in the white adipose and brown adipose tissues. It is possible that acetate has effects on lipid metabolism in the skeletal muscles and the adipose tissues, and has functions that work against obesity and obesity-linked type 2 diabetes.
Yamashita
Hiromi
H
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Soja, Okayama, Japan. yamashit@fhw.oka-pu.ac.jp
Maruta
Hitomi
H
Jozuka
Michiyo
M
Kimura
Rie
R
Iwabuchi
Hiromi
H
Yamato
Makiko
M
Saito
Tsukasa
T
Fujisawa
Katsuhiko
K
Takahashi
Yoshitaka
Y
Kimoto
Masumi
M
Hiemori
Miki
M
Tsuji
Hideaki
H
D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000009:Abdominal Muscles / Q000187:drug effects / Q000378:metabolism; D000085:Acetates / Q000494:pharmacology*; D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D052437:Adipocytes, Brown / Q000187:drug effects / Q000378:metabolism; D052438:Adipocytes, White / Q000187:drug effects / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology; D004734:Energy Metabolism / Q000187:drug effects; D005786:Gene Expression Regulation / Q000187:drug effects; D051275:Glucose Transporter Type 4 / Q000235:genetics; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism*; D009211:Myoglobin / Q000235:genetics; D010100:Oxygen / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D020334:Rats, Inbred OLETF
D000085:Acetates; D051275:Glucose Transporter Type 4; D009211:Myoglobin; D012333:RNA, Messenger; C495694:Slc2a4 protein, rat; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D055372:AMP-Activated Protein Kinases; D010100:Oxygen