A case of systemic amyloidosis following ankylosing spondylitis associated with congestive heart failure.
Secondary (amyloid A [AA]) amyloidosis is a systemic disease characterized by amyloid deposition in many organs, leading to impaired function. Although cardiac involvement may occur with AA amyloidosis, significant deposition of amyloid in the heart is considered an infrequent observation and is rarely the cause of death. It occurs in 5% of patients with poorly controlled chronic inflammatory disease, mainly rheumatoid arthritis, ankylosing spondylitis, and familial Mediterranean fever. The authors report a case of AA amyloidosis diagnosed by rectal and skin biopsies, with cardiac involvement demonstrated by typical echocardiographic features in the presence of low voltage on electrocardiography.
Ha
Sang Jin
SJ
Division of Cardiology, Department of Internal Medicine, School of Medicine, Kyung Hee University, Seoul, Korea.
Kim
Woo-Shik
WS
Hwang
Seung-Joon
SJ
Woo
Jong Shin
JS
Shon
Il Seok
IS
Bae
Jong-Hoa
JH
Kim
Kwon Sam
KS
D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000209:etiology*; D006333:Heart Failure / Q000150:complications* / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000150:complications* / Q000000981:diagnostic imaging*; D014463:Ultrasonography