title: Drug targets in infections with Ebola and Marburg viruses.
abstract: The development of antiviral drugs for Ebola and Marburg viruses has been slow. To date, beyond supportive care, no effective treatments, prophylactic measures, therapies, or vaccines are approved to treat or prevent filovirus infections. In this review, we examine the current treatments available to administer care for filovirus infection, the potential therapeutic targets that can be used for filovirus drug development, and the various drug targeting techniques used against filoviruses.
authors.affiliation: United States Army Medical Research Institute of Infectious Diseases, Division of Virology, Frederick, Maryland 21702-5011, USA.
authors.forename: Olinger G
authors.initials: OG
authors.lastname: Gene
authors.forename: Biggins E
authors.initials: BE
authors.lastname: Julia
authors.forename: Melanson R
authors.initials: MR
authors.lastname: Vanessa
authors.forename: Wahl-Jensen
authors.initials: WJ
authors.lastname: Victoria
authors.forename: Geisbert W
authors.initials: GW
authors.lastname: Thomas
authors.forename: Hensley E
authors.initials: HE
authors.lastname: Lisa
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D029043:Ebolavirus / Q000187:drug effects*; D019142:Hemorrhagic Fever, Ebola / Q000188:drug therapy* / Q000473:pathology / Q000821:virology*; D006801:Humans; D007167:Immunotherapy; D008379:Marburg Virus Disease / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D029024:Marburgvirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents