title: Fetal borderline cerebral ventriculomegaly: clinical significance and management.
abstract: OBJECTIVE
  The aim of this study was to evaluate the clinical significance and the management of fetal borderline lateral cerebral ventriculomegaly.
  
  
  METHODS
  Fetuses with a sonographic diagnosis of lateral cerebral ventriculomegaly isolated or associated to other fetal malformations were followed monthly and a review of the English-language literature was made.
  
  
  RESULTS
  Of 86 fetuses analyzed, 30 suffered from hydrocephaly (monolateral, bilateral), 56 showed also several other malformations . Chromosomal aberrations is possible also in case of isolated hydrocephaly. Neurological sequelae, mostly a mild to moderate delay in cognitive and/or motor development, is present in 10% of the cases.
  
  
  CONCLUSIONS
  In most cases, isolated borderline lateral cerebral ventriculomegaly has no consequence. However, the risk of cerebral maldevelopment, delayed neurological development and, possibly, chromosomal aberrations is increased. The optimum management of these cases remains uncertain.
authors.affiliation: Ostetrics and Ginecology Emergency Unit, Department of Ostetrics, Ginecology and Reproduction Physiopathology, University Federico II, Naples, Italy. martinel@unina.it
authors.forename: S
authors.initials: S
authors.lastname: Simioli
authors.forename: R
authors.initials: R
authors.lastname: Napolitano
authors.forename: F
authors.initials: F
authors.lastname: Quaglia
authors.forename: L L
authors.initials: LL
authors.lastname: Mazzarelli
authors.forename: A
authors.initials: A
authors.lastname: Agangi
authors.forename: G Mallia
authors.initials: GM
authors.lastname: Milanes
authors.forename: G
authors.initials: G
authors.lastname: Tessitore
authors.forename: A
authors.initials: A
authors.lastname: Iannaccone
authors.forename: G M
authors.initials: GM
authors.lastname: Maruotti
authors.forename: P
authors.initials: P
authors.lastname: Martinelli
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D000029:Abortion, Legal; D000328:Adult; D002552:Cerebral Ventricles / Q000002:abnormalities; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging*; D020547:Lateral Ventricles / Q000002:abnormalities*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D016216:Ultrasonography, Prenatal