Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab')2 components mediates reduced pulmonary inflammation in mice.
Therapeutic treatment with a non-neutralizing monoclonal antibody (mAb) (131-2G) specific to respiratory syncytial virus (RSV) G glycoprotein mediates virus clearance and decreases leukocyte trafficking and interferon gamma (IFN-gamma) production in the lungs of RSV-infected mice. Its F(ab')(2) component only mediates decreased leukocyte trafficking and IFN-gamma production without reducing virus replication. Thus, this mAb has two independent actions that could facilitate treatment and/or prevention of RSV infection by reducing both virus replication and virus-induced pulmonary inflammation.
Miao
Congrong
C
National Centers for Immunization and Respiratory Disease, Division of Viral Diseases, Respiratory and Gastroenteritis Viruses Laboratory Branch, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30333, USA.
Radu
Gertrud U
GU
National Centers for Immunization and Respiratory Disease, Division of Viral Diseases, Respiratory and Gastroenteritis Viruses Laboratory Branch, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30333, USA.
Caidi
Hayat
H
National Centers for Immunization and Respiratory Disease, Division of Viral Diseases, Respiratory and Gastroenteritis Viruses Laboratory Branch, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30333, USA.
Tripp
Ralph A
RA
College of Veterinary Medicine, Department of Infectious Disease, University of Georgia, Athens, GA 30602, USA.
Anderson
Larry J
LJ
National Centers for Immunization and Respiratory Disease, Division of Viral Diseases, Respiratory and Gastroenteritis Viruses Laboratory Branch, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30333, USA.
Haynes
Lia M
LM
National Centers for Immunization and Respiratory Disease, Division of Viral Diseases, Respiratory and Gastroenteritis Viruses Laboratory Branch, Centers for Disease Control and Prevention (CDC), 1600 Clifton Road NE, Atlanta, GA 30333, USA.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D008168:Lung / Q000166:cytology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology* / Q000473:pathology; D012136:Respiratory Syncytial Viruses / Q000378:metabolism*; D013997:Time Factors; D014760:Viral Fusion Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; C502275:G glycoprotein, Respiratory syncytial virus; D007140:Immunoglobulin Fab Fragments; D014760:Viral Fusion Proteins