Avian Aspergillus fumigatus strains resistant to both itraconazole and voriconazole.
The in vitro susceptibilities of 59 avian Aspergillus fumigatus strains to amphotericin B, itraconazole, and voriconazole were determined using the standard microdilution broth method (CLSI M38-A2). Four isolates showed acquired resistance to itraconazole and voriconazole, harboring implications for the treatment of aspergillosis in both birds and humans.
Beernaert
L A
LA
Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. lies.beernaert@ugent.be
Pasmans
F
F
Van Waeyenberghe
L
L
Dorrestein
G M
GM
Verstappen
F
F
Vercammen
F
F
Haesebrouck
F
F
Martel
A
A
D000666:Amphotericin B / Q000494:pharmacology; D000818:Animals; D000829:Animals, Domestic / Q000382:microbiology; D000835:Animals, Wild / Q000382:microbiology; D000935:Antifungal Agents / Q000494:pharmacology*; D001228:Aspergillosis / Q000382:microbiology / Q000662:veterinary*; D001232:Aspergillus fumigatus / Q000187:drug effects* / Q000302:isolation & purification; D001715:Bird Diseases / Q000382:microbiology*; D025141:Drug Resistance, Fungal; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D000666:Amphotericin B; D065819:Voriconazole