Predicting aspiration after hemispheric stroke from timing measures of oropharyngeal bolus flow and laryngeal closure.
Deglutitive aspiration is common after stroke, affecting up to 50% of patients and predisposing them to pneumonia, yet it is virtually impossible to predict those patients at greatest risk. The aim of this study was to develop a robust predictive model for aspiration after stroke. Swallowing was assessed by digital videofluoroscopy (VF) in 90 patients following hemispheric stroke. Lesion characteristics were determined by computerized tomography (CT) brain scan using the Alberta Stroke Programme Early CT Score (ASPECTS). Aspiration severity was measured using a validated penetration-aspiration scale. The probability of aspiration was then determined from measures of swallowing pathophysiology and lesion location by discriminant analysis. Aspiration was observed in 47 (52%) patients, yet despite disrupted swallowing physiology, intrasubject aspiration scores were variable. The best discriminant model combined pharyngeal transit time, swallow response time, and laryngeal closure duration to predict 73.11% of those aspirating (sensitivity = 66.54, specificity = 80.22, p > 0.001). The addition of lesion location did not add anything further to the predictive model. We conclude that the pathophysiology of poststroke aspiration is multifactorial but in most cases can be predicted by three key swallowing measurements. These measurements, if translatable into clinical bedside evaluation, may assist with the development of novel measurement and intervention techniques to detect and treat poststroke aspiration.
Power
Maxine L
ML
Department of Rehabilitation and Human Performance Research, University of Salford, Salford, Greater Manchester M5 4WT, UK. Maxine.power@srft.nhs.uk
Hamdy
Shaheen
S
Goulermas
John Y
JY
Tyrrell
Pippa J
PJ
Turnbull
Ian
I
Thompson
David G
DG
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003680:Deglutition Disorders / Q000209:etiology*; D005260:Female; D005471:Fluoroscopy; D006305:Health Status Indicators; D006429:Hemiplegia / Q000150:complications*; D006801:Humans; D007818:Laryngeal Diseases / Q000209:etiology*; D007830:Larynx / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009960:Oropharynx / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D053120:Respiratory Aspiration / Q000209:etiology*; D012307:Risk Factors; D013997:Time Factors; D014741:Video Recording