Antimitotic chalcones and related compounds as inhibitors of tubulin assembly.
The development of chalcones as antimitotic agents has led to the design of other analogues able to interact with tubulin and inhibit its assembly into microtubules. This activity has also been associated with their anti-vascular activity. This review focuses on the development of chalcones and related analogues as antimitotic agents.
Ducki
Sylvie
S
ENSCCF, Clermont Université, Aubière, France. Sylvie.DUCKI@univ-bpclermont.fr
D000818:Animals; D050256:Antimitotic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D008870:Microtubules / Q000187:drug effects* / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
D050256:Antimitotic Agents; D047188:Chalcones; D014404:Tubulin