[Effects of puerarin with aspirin on the markers of damaged vascular endothelial cells in patients with acute cerebral infarction].
OBJECTIVE
To investigate the effects of puerarin with aspirin on the markers of damaged vascular endothelial cells, as von Willebrand factor (vWF), and thrombomodulin (TM) in patients with acute cerebral infarction (ACI).


METHODS
Forty-five patients with ACI were included in this study and divided into basic treatment and puerarin groups, meanwhile 26 healthy persons selected as control group. The serum vWF and sTM concentrations were measured by enzyme-linked immunosorbant assay (ELISA) and national institute health stroke scale (NIHSS) score was evaluated at admission and 14 days later after treatment.


RESULTS
The level of serum vWF significantly increased in patients with ACI compared to control and major stroke had higher vWF level than minor stroke (P < 0.01), but the serum level of sTM had no obviously differences respectively. Correlation analysis showed that there is a positive correlation between the level of vWF and NIHSS score (P < 0.05, r = 0.368), while the significant correlations between the level of vWF and sTM, sTM and NIHSS score were not observed. After 14 days treatment, the level of serum vWF and NIHSS score were obviously decreased in patients treated with puerarin and aspirin, not in basic treated patients. The level of sTM was increased in patients after 14 d, while puerarin treated patient has lower sTM level than patients with basic treatment (P < 0.05).


CONCLUSIONS
Patients with ACI cotreated with puerarin and aspirin improved the neurological function, decreased the levels of serum vWF and sTM, indicating puerarin with aspirin had the protective effects on the damaged vascular endothelial cells.
Hu
Hai-tao
HT
The Second Affiliated Hospital, Medical School, Zhejiang University, Hangzhou 310009, China.
Fen
Fei
F
Ding
Mei-ping
MP
D000208:Acute Disease; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage*; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000378:metabolism; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D018180:Thrombomodulin / Q000378:metabolism*; D014841:von Willebrand Factor / Q000378:metabolism*
D007529:Isoflavones; D018180:Thrombomodulin; D014841:von Willebrand Factor; D001241:Aspirin; C033607:puerarin