Dihydrostilbene derivatives from the Mongolian medicinal plant Scorzonera radiata.
Chromatographic separation of a crude extract obtained from aerial parts of the Mongolian medicinal plant Scorzonera radiata yielded five new dihydrostilbenes, scorzodihydrostilbenes A-E (1-5). The structures were unambiguously elucidated on the basis of one- and two-dimensional NMR ((1)H, (13)C, COSY, HMBC, HMQC, and ROESY) and mass spectrometric data. Compounds 1-5 exhibited antioxidative activity when analyzed in the DPPH (2,2-diphenyl-1-picrylhydrazyl) assay. For 1 and 5 the antioxidant activities were stronger than that of the well-known naturally occurring stilbene antioxidant resveratrol.
Wang
Yao
Y
Institut fur Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universitat Dusseldorf, Dusseldorf, Germany.
Edrada-Ebel
RuAngelie
R
Tsevegsuren
Nanzad
N
Sendker
Jandirk
J
Braun
Manfred
M
Wray
Victor
V
Lin
Wenhan
W
Proksch
Peter
P
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D000077185:Resveratrol; D031186:Scorzonera / Q000737:chemistry*; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000975:Antioxidants; D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D010851:Picrates; D013267:Stilbenes; C004931:1,1-diphenyl-2-picrylhydrazyl; D000077185:Resveratrol