Multipurpose disinfecting solutions and their interactions with a silicone hydrogel lens.
OBJECTIVE
To assess the compatibility of a new silicone hydrogel lens, asmofilcon A (with four multipurpose disinfecting solutions: OPTIFREE RepleniSH, ReNu MultiPlus, Solo-Care Aqua and MeniCare Soft). Ocular responses and subjective responses were monitored with each lens-care system combination.


METHODS
The study was conducted as a prospective, bilateral, clinical trial with a single-masked investigator, and randomized cross-over design with four phases, (one for each care system). Each study phase comprised of two consecutive days of lens wear where the lenses were inserted on day 1 directly from the blister-packs and worn for over 8 hr, then inserted on day 2 after overnight disinfection with one of the study lens care systems. Twenty-five adapted soft contact lens wearers who were able to wear their habitual lenses comfortably for more than 12 hr were recruited.


RESULTS
There were statistically significant differences in corneal staining found for all the lens-care systems when comparing the results of day 1 (from the blister pack) with day 2 (following care system use) (P < 0.05). ReNu MultiPlus solution had the highest grade for corneal staining at the 2-hr time point on day 2 which then decreased by 6 hr (P < 0.05). There was no difference between the lens care systems and the rating of subjective comfort over either of the two days. The rating of dryness and burning sensations were only slightly increased at 6 hr for all lens care systems except ReNu MultiPlus where burning was highest on insertion (P < 0.05).


CONCLUSIONS
Corneal staining observed in this study does not seem to have been related to the presence of polyhexamethylene biguanide (0.0001% wv) that was present in three of the four care systems. Only one care system (ReNu MultiPlus) demonstrated an associated level of corneal staining that was statistically significant; however, this was not considered to be of clinical relevance. These results suggest that using this novel surface-treated silicone hydrogel lens may result in less lens and lens care-related interactions.
Sorbara
Luigina
L
Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada. gsorbara@scimail.uwaterloo.ca
Peterson
Rachael
R
Woods
Craig
C
Fonn
Desmond
D
D000293:Adolescent; D000328:Adult; D018639:Contact Lens Solutions / Q000009:adverse effects / Q000494:pharmacology*; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000187:drug effects; D018592:Cross-Over Studies; D005123:Eye; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000139:chemically induced; D020034:Silicone Gels; D016037:Single-Blind Method; D013194:Staining and Labeling; D013997:Time Factors; D014985:Xerophthalmia / Q000139:chemically induced; D055815:Young Adult
D018639:Contact Lens Solutions; D020034:Silicone Gels