title: Vaccination reduces the viral load and the risk of transmission of Jembrana disease virus in Bali cattle.
abstract: The efficacy of a tissue-derived vaccine, which is currently used in Indonesia to control the spread of Jembrana disease in Bali cattle, was determined by quantifying the viral load in plasma following experimental infection with Jembrana disease virus. Virus transmission is most likely to occur during the acute phase of infection when viral titers are greater than 10(6) genomes/ml. Vaccinated cattle were found to have a 96% reduction in viral load above this threshold compared to control cattle. This would reduce the chance of virus transmission as the number of days above the threshold in the vaccinated cattle was reduced by 33%. Viral loads at the onset and resolution of fever were significantly lower in the vaccinated cattle and immune function was maintained with the development of antibody responses to Env proteins within 10-24 days post challenge. There was, however, no significant reduction in the duration of the febrile period in vaccinated animals. The duration and severity of clinical parameters were found to be variable within each group of cattle but the quantification of viral load revealed the benefits of vaccinating to reduce the risk of virus transmission as well as to ameliorate disease.
authors.affiliation: School of Veterinary and Biomedical Science, Murdoch University, Perth, Western Australia 6150, Australia.
authors.forename: William G F
authors.initials: WG
authors.lastname: Ditcham
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Lewis
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Dobson
authors.forename: Nining
authors.initials: N
authors.lastname: Hartaningsih
authors.forename: Graham E
authors.initials: GE
authors.lastname: Wilcox
authors.forename: Moira
authors.initials: M
authors.lastname: Desport
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D005260:Female; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D016180:Lentivirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D017960:Lentiviruses, Bovine / Q000276:immunology*; D016014:Linear Models; D012367:RNA, Viral / Q000032:analysis; D014611:Vaccination / Q000662:veterinary; D019562:Viral Load; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D012367:RNA, Viral; D014765:Viral Vaccines