[An experimental study on pulmonary toxicity water extracts of Siegesbeckia pubescens on mice].
OBJECTIVE
The pulmonary toxicity of water extract of Siegesbeckia pubescens has been studied an mice following subchronic oral administration route.


METHODS
Mice were randomly grouped and administered with the water extract of S. pubescens at dosages of 3.0, 1.0, 0.3 g x kg(-1) and saline respectively. 10 mice of each group were sacrificed on the day of 7 th, 14 th, 21 th, and 2 weeks after stopping administration, histological changes of the lung were examined.


RESULTS
The water extract of S. pubescens at dosage of 3.0 g x kg(-1) increased the lung index on the of day 14 th and 21 th, significant histopathological damages were observed. The histopathological changes were disappeared after stopping administration for 2 weeks.


CONCLUSIONS
The water extract of S. pubescens has a pulmonary toxic effect on mice, and the toxic effect is reversible.
Guan
Jian-hong
JH
Shanxi University of Traditional Chinese Medicine, Taiyuan 030024, China. gjh1688@sina.com
Xue
Zheng
Z
Liu
Bing-chen
BC
Ren
Jin-bin
JB
D000284:Administration, Oral; D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*; D005260:Female; D008168:Lung / Q000187:drug effects*; D008297:Male; D051379:Mice; D011897:Random Allocation
D004365:Drugs, Chinese Herbal