title: Stability of analytes related to clinical chemistry and bone metabolism in blood specimens after delayed processing.
abstract: OBJECTIVE
  We investigated the stability of 36 analytes related to clinical chemistry in a controlled storage study.
  
  
  METHODS
  Blood was collected from 11 subjects and was maintained for 45 min, 2.5 h, 5 h, or 24 h after phlebotomy before centrifugation.
  
  
  RESULTS
  Statistically significant changes were observed only for parathyroid hormone, osteocalcin, zinc, pyridoxal 5'-phosphate, and homocysteine.
  
  
  CONCLUSIONS
  These studies indicate that many analytes in clinical chemistry are stable for 24 h before centrifugation.
authors.affiliation: Universities Space Research Association, Houston, TX, USA. sara.zwart-1@nasa.gov
authors.forename: Sara R
authors.initials: SR
authors.lastname: Zwart
authors.forename: Megan
authors.initials: M
authors.lastname: Wolf
authors.forename: Ann
authors.initials: A
authors.lastname: Rogers
authors.forename: Shanna
authors.initials: S
authors.lastname: Rodgers
authors.forename: Patti L
authors.initials: PL
authors.lastname: Gillman
authors.forename: Kristen
authors.initials: K
authors.lastname: Hitchcox
authors.forename: Karen L
authors.initials: KL
authors.lastname: Ericson
authors.forename: Scott M
authors.initials: SM
authors.lastname: Smith
mesh_terms: D001842:Bone and Bones / Q000378:metabolism*; D002498:Centrifugation; D002624:Chemistry, Clinical / Q000379:methods*; D006801:Humans; D015675:Osteocalcin / Q000097:blood; D010281:Parathyroid Hormone / Q000097:blood; D018962:Phlebotomy; D011732:Pyridoxal Phosphate / Q000097:blood; D013048:Specimen Handling; D013997:Time Factors
chemical_list: C470125:PTH protein, human; D010281:Parathyroid Hormone; D015675:Osteocalcin; D011732:Pyridoxal Phosphate