Anti-aging effect of rice wine in cultured human fibroblasts and keratinocytes.
The application of rice wine on skin is known to have beneficial effects such as enhancement of the skin barrier function and skin whitening. In this study, we focused on examination of the anti-aging effects of rice wine. The treatment of fibroblasts with rice wine in vitro increased the expression of procollagen and laminin-5, a key basement membrane component in cultured human fibroblasts. Rice wine significantly reduced the expression of UV-induced matrix metalloproteinase-1 (MMP-1) in a dose-dependent manner in both cultured human fibroblasts and keratinocytes. In addition, treatment with rice wine decreased UV-induced tumor necrosis factor-alpha (TNF-alpha) production in human keratinocytes. An in vivo study using hairless mice showed that topical application of rice wine protected mouse skin from photoaging. Thus, we suggest that rice wine may have potential as an effective agent for the prevention and treatment of UV-induced skin aging.
Seo
Miy-Young
MY
Doosan R&D Center, 39-3 Sungbok-dong, Yongin-si, Gyeonggi-do 449-795, Republic of Korea.
Chung
So-Young
SY
Choi
Wang-Keun
WK
Seo
Young-Kwon
YK
Jung
Su-Hyun
SH
Park
Jung-Min
JM
Seo
Min-Jae
MJ
Park
Jung-Keug
JK
Kim
Jin-Wook
JW
Park
Chang-Seo
CS
D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D007797:Laminin / Q000378:metabolism; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis; D051379:Mice; D008812:Mice, Hairless; D012275:Oryza; D011347:Procollagen / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects; D014920:Wine
D007797:Laminin; D011347:Procollagen; D014409:Tumor Necrosis Factor-alpha; D020781:Matrix Metalloproteinase 1