title: Higher laryngeal preservation rate after CO2 laser surgery compared with radiotherapy in T1a glottic laryngeal carcinoma.
abstract: BACKGROUND
  Clinical outcome of endoscopic CO(2) laser surgery and radiotherapy in early-stage glottic laryngeal carcinoma is difficult to compare because of differences in treatment selection and patient groups. Therefore, we compared local control, overall survival, and laryngeal preservation in a homogenous group of patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with either CO(2) laser surgery or radiotherapy.
  
  
  METHODS
  Retrospective survival analysis was performed on 100 patients with T1a glottic carcinoma treated with CO(2) laser surgery (n = 49) or radiotherapy (n = 51), diagnosed at the University Medical Center Groningen between 1990 and 2004.
  
  
  RESULTS
  No significant differences in local control and overall survival were found. Ultimate 5-year laryngeal preservation was significantly better in the CO(2) laser surgery group (95% vs 77%, p = .043).
  
  
  CONCLUSIONS
  Patients with T1a glottic carcinoma with normal/diminished mucosal wave treated with CO(2) laser surgery had a significantly better laryngeal preservation rate than patients treated with radiotherapy.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck surgery, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Schrijvers
authors.forename: Eva L
authors.initials: EL
authors.lastname: van Riel
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Langendijk
authors.forename: Frederik G
authors.initials: FG
authors.lastname: Dikkers
authors.forename: Ed
authors.initials: E
authors.lastname: Schuuring
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: van der Wal
authors.forename: Bernard F A M
authors.initials: BF
authors.lastname: van der Laan
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005931:Glottis / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D053685:Laser Therapy / Q000379:methods* / Q000401:mortality; D054020:Lasers, Gas; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011788:Quality of Life; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012189:Retrospective Studies; D018570:Risk Assessment; D016019:Survival Analysis; D016896:Treatment Outcome; D014833:Voice Quality