Paraneoplastic necrotizing myelopathy in a patient with advanced esophageal cancer: An autopsied case report.
We report the first autopsied case of paraneoplastic necrotizing myelopathy associated with esophageal cancer in the literature. The patient had acute flaccid paraplegia and urinary retention, and had a good recovery of strength of both legs in response to corticosteroids. MRI showed a characteristic lesion with post-gadolinium enhancement of the cervical to mid-thoracic spinal cord at the onset, which has never been reported. Taken together, these results suggest that there is an underlying autoimmune mechanism in paraneoplastic necrotizing myelopathy.
Urai
Yoshiteru
Y
Department of Gastroenterology and Neurology, School of Medicine, Kagawa University, Japan. yurai@med.kagawa-u.ac.jp
Matsumoto
Kouichi
K
Shimamura
Mieko
M
Ikeda
Kazuyo
K
Tsukaguchi
Masago
M
Deguchi
Kazushi
K
Touge
Tetsuo
T
Ueno
Masaki
M
Sakamoto
Haruhiko
H
Kuriyama
Shigeki
S
Kinekawa
Fumihiko
F
Kurokohchi
Kazutaka
K
Uchida
Naohito
N
Masaki
Tsutomu
T
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D002574:Cervical Vertebrae; D003937:Diagnosis, Differential; D004938:Esophageal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D020361:Paraneoplastic Syndromes, Nervous System / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D013904:Thoracic Vertebrae