The effects of terpenes on the permeation of lidocaine and ofloxacin from moisture-activated patches.
The effects of terpenes on the release and permeation of ofloxacin and lidocaine from moisture-activated composite patches were investigated. Ofloxacin without enhancers showed very low permeation rate (0.58 microg/cm(2)/hr), and the addition of cineole enhanced the permeation flux 14.1-times; /-menthol and d-limonene increased it 4.7- and 3.5-times, respectively. The highest permeation flux (77.7 +/- 25.3 microg/cm(2)/hr) of lidocaine from the composite patches was also achieved when cineole at the concentration of 0.33% in the gel base was added. /-Menthol also revealed enhancing effect on the permeation of lidocaine; however, d-limonene failed to increase the permeation rate of lidocaine. In conclusion, for effective moisture- activated patches containing lidocaine and ofloxacin, cineole could be used as an effective and safe enhancer.
Song
Yeon Hwa
YH
College of Pharmacy, Dongduk Women's University, Seoul, Korea.
Gwak
Hye Sun
HS
Chun
In Koo
IK
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000180:Acrylic Resins / Q000737:chemistry; D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology*; D000279:Administration, Cutaneous; D000818:Animals; D001682:Biological Availability; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D003511:Cyclohexanols / Q000494:pharmacology; D053138:Cyclohexenes / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D000077591:Eucalyptol; D005079:Excipients / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry; D066298:In Vitro Techniques; D008012:Lidocaine / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D000077222:Limonene; D008297:Male; D008298:Maleates / Q000737:chemistry; D008610:Menthol / Q000494:pharmacology; D051379:Mice; D008812:Mice, Hairless; D039821:Monoterpenes / Q000494:pharmacology; D015242:Ofloxacin / Q000008:administration & dosage / Q000378:metabolism* / Q000493:pharmacokinetics; D011095:Polyethylenes / Q000737:chemistry; D011136:Polysorbates / Q000494:pharmacology; D012869:Skin Absorption / Q000187:drug effects*; D013729:Terpenes / Q000494:pharmacology*; D047392:beta-Cyclodextrins / Q000737:chemistry
D000180:Acrylic Resins; D000277:Adjuvants, Pharmaceutic; D003511:Cyclohexanols; D053138:Cyclohexenes; D005079:Excipients; D020100:Hydrogels; D008298:Maleates; D039821:Monoterpenes; D011095:Polyethylenes; D011136:Polysorbates; D013729:Terpenes; D047392:beta-Cyclodextrins; C479038:carbomer; D008610:Menthol; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002482:Cellulose; C002283:hydroxyethylcellulose; C043105:poly(methyl vinyl ether-co-maleic anhydride); D008012:Lidocaine; D000077222:Limonene; D015242:Ofloxacin; D000077591:Eucalyptol