The effect of microelements supplementation on beta-oxidation activity in healthy and type 1 diabetic rats.
Diabetes mellitus type 1 disease changes the activity of fatty acid degradation as compared to healthy animals. Supplementation in vitro with microelements chromium Cr3+ and selenium Se4+ and Se2- in non-toxic ([96.15 pmol (5 ppm) for chromium and 6.33 micromol (0.5 ppm) for selenium] concentrations strongly stimulates the activity of this process in diabetic rats. In healthy animals only chromium Cr3+ in concentration of 96.15 micromol (5 ppm) stimulated beta-oxidation activity in lymphocytes. It may indicate the beneficial effect of supplementation of the diet with microelements, chromium Cr3 and selenium Se4+ or Se2- at concentrations as low as 100 micromol for chromium and 6 micromol for selenium, respectively.
Kuryl
Tomasz
T
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Nowoursynowska 159, 02-776 Warsaw, Poland. Tomasz_Kuryl@SGGW.pl
Debski
Bogdan
B
Martinik
Karel
K
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D017608:Chromium Compounds / Q000378:metabolism / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000178:diet therapy / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism*; D019587:Dietary Supplements; D005227:Fatty Acids / Q000378:metabolism / Q000493:pharmacokinetics; D007328:Insulin / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D018036:Selenium Compounds / Q000378:metabolism / Q000494:pharmacology*; D013311:Streptozocin / Q000008:administration & dosage / Q000378:metabolism; D014131:Trace Elements / Q000008:administration & dosage* / Q000378:metabolism; D015430:Weight Gain / Q000187:drug effects
D001786:Blood Glucose; D017608:Chromium Compounds; D005227:Fatty Acids; D007328:Insulin; D018036:Selenium Compounds; D014131:Trace Elements; D013311:Streptozocin