[miRNAs play an essential role in stem cell self-renewal and differentiation].
Stem cells and miRNAs are two of the most intriguing research topics in recent years. Stem cells with properties of self-renewal and multipotency are remarkable cells since they play key roles in animal development and tumorigenesis. microRNAs (miRNAs) are approximately 22nt non-coding RNAs, which have spatiotemporally specific expression patterns, and are highly conserved between species. Researchers have demonstrated that miRNAs can regulate gene expression at post-transcriptional level, and their action is one of the essential intracellular regulatory pathways. Recent evidence showed that miRNAs can regulate stem cells self-renewal and differentiation. The evidence mostly derived from the following research strategies: (1) deletion or mutation of the genes that encoding essential enzymes for miRNAs biogenesis, such as Dicer1, Loqs, DGCR8, and Argonaute; (2) screening of specific miRNAs from stem cells and investigation of their function. Comprehension of the miRNAs functions in stem cells is of great importance for further understanding their self-renewal and differentiation mechanism, as well as identification of stem cells. This paper reviews the potential roles of miRNAs in stem cells on the basis of recent researches.
An
Yang
Y
Laboratory of Animal Development Biology, College of Life Science, Northeast Forestry University, Harbin 150040, China. AN.Yang.public@gmail.com
An
Tie-Zhu
TZ
Teng
Chun-Bo
CB
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D019070:Cell Lineage; D055088:Early Detection of Cancer; D006412:Hematopoietic Stem Cells; D006801:Humans; D035683:MicroRNAs / Q000235:genetics / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology
D035683:MicroRNAs