title: [Surveillance network of bacterial meningitis in children, 7 years of survey in France].
abstract: OBJECTIVE
  Consequence of the introduction of vaccines against bacteria involved in meningitis in children and various recommendations concerning antibiotics, the epidemiology of bacterial meningitis has changed during the last fifteen years. The GPIP/ACTIV (Groupe de Pathologie Infectieuse Pédiatrique and Association Clinique et Thérapeutique Infantile du Val de Marne) set up an active surveillance network to analyze the clinical and biological features of bacterial meningitis.
  
  
  METHODS
  From 2001 to 2007, 252 French pediatric wards working with 168 microbiology laboratories enrolled all children (0-18 years old) with bacterial meningitis. Risk factors, vaccination status, signs and symptoms, cerebrospinal fluid analysis, treatments and case fatality rate were recorded.
  
  
  RESULTS
  2951 cases of bacterial menigitis were recorded by 237 pediatric wards. Geographical distribution covered a large part of the national territory. Overall, the annual number of cases varied from 452 (in 2001 and 2003) to 378 (in 2004). Meningococcal and pneumococcal meningitis respectively represented about the half (46 %) and the third (28 %) of cases. Few cases of Haemophilus influenzae meningitis were reported (3 %). For the neonatal period, group B Streptococcus and E. coli were the most frequently identified pathogens. In children less than one year old, pneumococcus was the first one, and after 1 year, meningococcus was predominant. The mortality rate varied according to bacteria, 6.6 % for the meningococcus, 11.6 % for pneumococcus, 14.1 % for group B streptococcus and 16.7 % for Listeria meningitis. It varied also with age, 14.9 % among infants 1 to 2 months old and 6.3 % in children over 5 years.
  
  
  CONCLUSIONS
  Closed to 3000 meningitis were recorded during seven years in children, which underlines the interest of the survey. This network is principally supported by the goodwill and availability of pediatricians and microbiologists who participate in the study. This special supplement issue of Archive de Pédiatrie allows a complete presentation of our results. In next following years, any amendment to the immunization schedule, any perspective of implementation of new vaccines will transform the epidemiology and clinical caracteristics of bacterial menigitis. Therefore, continued surveillance appears necessary.
authors.affiliation: GPIP (Groupe de Pathologie Infectieuse Pédiatrique) de la SFP (Société Française de Pédiatrie), 27 rue Inkermann, F94100 Saint Maur des Fossés, France. activ@activfrance.fr
authors.forename: C
authors.initials: C
authors.lastname: Levy
authors.forename: E
authors.initials: E
authors.lastname: Bingen
authors.forename: Y
authors.initials: Y
authors.lastname: Aujard
authors.forename: M
authors.initials: M
authors.lastname: Boucherat
authors.forename: D
authors.initials: D
authors.lastname: Floret
authors.forename: D
authors.initials: D
authors.lastname: Gendrel
authors.forename: R
authors.initials: R
authors.lastname: Cohen
mesh_terms: D002648:Child; D002675:Child, Preschool; D005602:France / Q000453:epidemiology; D005843:Geography; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology