The effects of vitamin E on NK cell activity and lymphocyte proliferation in treated mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
The study was conducted to investigate the effects of vitamin E on NK cell activity and lymphocyte proliferation in tr eated female mice by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). In chronic TCDD trial, 45 mice were divided into 5 groups, and the levels of TCDD and vitamin E were 0 and 0, 100 and 0, 100 and 20, 100 and 100, and 100 ng/kg/d and 500 mg/kg/d, respectively. In acute TCDD trial, 24 mice were divided into three groups, and the levels of TCDD and vitamin E were 0 and 0, 30 and 0, and 30 microg/kg and 100 mg/kg, respectively. The results showed chronic TCDD-treatment caused decrease tendencies of spleen NK cell activity and lymphocyte proliferation, and vitamin E 100mg/kg alleviated the decreases tendencies caused by chronic TCDD-treatment, and the lymphocyte proliferation in the group given vitamin E 100mg/kg was significantly higher than that of the chronic TCDD-treated group. Acute TCDD-treatment suppressed the NK cell activity and lymphocyte proliferation, and vitamin E 100mg/kg significantly alleviated the decrease caused by acute TCDD-treatment. These results suggested that TCDD resulted in immunotoxicity, and the toxicity of acute TCDD-treatment was severe compared with chronic TCDD, while vitamin E alleviated the immunotoxicity from TCDD.
Wang
Xiao-Hui
XH
Department of Laboratory Animal Science, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
Zhou
Xian-Qing
XQ
Xu
Jian-Ping
JP
Wang
Ying
Y
Lu
Jing
J
D000818:Animals; D000975:Antioxidants / Q000009:adverse effects* / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D007694:Killer Cells, Natural / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice; D008813:Mice, Inbred ICR; D000072317:Polychlorinated Dibenzodioxins / Q000819:agonists / Q000633:toxicity*; D013723:Teratogens / Q000633:toxicity*; D014810:Vitamin E / Q000009:adverse effects* / Q000494:pharmacology
D000975:Antioxidants; D000072317:Polychlorinated Dibenzodioxins; D013723:Teratogens; D014810:Vitamin E