title: [Immune mechanisms of inflammation in dilated cardiomyopathy].
abstract: OBJECTIVE
  To study immune mechanisms of inflammation in dilated cardiomyopathy (DCM).
  
  
  METHODS
  The study of main markers of immune activation was conducted in 44 patients with DCM with stage I - IIB and NYHA functional class (FC) I - IV chronic heart failure (CHF). Among them there were 42 men (95%) and 2 women (5%) in the age from 22 to 61 years. Mean age was 43(10) years. According to FC the patients were distributed in the following way: FC I--10 (23%), FC II--9 (20%), FC III--13 (30%), FC IV--12 (27%). EchoCG was carried out by standard recommendations with assessment of systolic and diastolic function of LV. Measurement of CRP, IgG, IgA, IgM was based on nephelometric method of detection. Content of Il-6, Il-18, Il-10, Il-10, sIl-2R, Il-8, IFN-gamma in blood serum was measured by the method of immunoenzyme analysis.
  
  
  RESULTS
  Elevation of levels of CRP, sIl-2R, Il-8 was established in DCM, what evidenced for the presence of inflammatory process. In the group of patients with DCM with rhythm disturbances (predominantly of atrial fibrillation type) elevation of levels of IFN-gamma, CRP was noted what probably was related to Th-1 type of inflammatory reaction. It was revealed that disturbances of diastolic function of the heart had inflammatory genesis (IFN-gamma correlated with parameter of diastolic function DT; elevation of Il-6 level was found in restrictive type of diastolic function).
  
  
  CONCLUSIONS
  Elevation of proinflammatory factors in DCM evidence for the presence of inflammatory process. there exist a link between elevated level of mediators of inflammation and complications of the disease--arrhythmia, worsening of heart failure class, deranged diastolic function of the heart.
authors.forename: S N
authors.initials: SN
authors.lastname: Tatenkulova
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Mareev
authors.forename: K A
authors.initials: KA
authors.lastname: Zykov
authors.forename: N A
authors.initials: NA
authors.lastname: Baklanova
authors.forename: E A
authors.initials: EA
authors.lastname: Beliavskiĭ
authors.forename: Iu N
authors.initials: IuN
authors.lastname: Belenkov
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D006801:Humans; D007109:Immunity / Q000276:immunology*; D007118:Immunoassay; D007136:Immunoglobulins / Q000097:blood*; D007249:Inflammation / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009391:Nephelometry and Turbidimetry; D055815:Young Adult
chemical_list: D016207:Cytokines; D007136:Immunoglobulins; D002097:C-Reactive Protein