An unexpected Bis-ligation of S-nitrosothiols.
A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.
Zhang
Jiming
J
Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
Wang
Hua
H
Xian
Ming
M
D004220:Disulfides; D007098:Imino Acids; D008722:Methods; D015538:Nitrosation; D010753:Phosphoranes; D011506:Proteins / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*
D004220:Disulfides; D007098:Imino Acids; D010753:Phosphoranes; D011506:Proteins; D026403:S-Nitrosothiols