Review paper: Cancer chemopreventive compounds and canine cancer.
Canine cancer has become more prevalent in recent years because of increased life expectancy and greater attention to the health of pets. The range of cancers seen in dogs is as diverse as that in human patients, and despite more intensive therapeutic interventions, fatality rates remain unacceptably high in both species. Chemoprevention is therefore an important means of confronting this disease. Because domestic pets share our environment, greater cross-application and study of the protumorigenic and antitumorigenic factors in our shared environment will benefit all species, leading to the development of new families of less toxic antitumorigenic compounds based on novel and established molecular targets. Currently, the most interesting cancer preventive agents are nonsteroidal anti-inflammatory drugs, peroxisome proliferator-activated receptor-gamma ligands, and dietary compounds. This article provides an overview of what is known about how these agents affect molecular signaling in neoplastic disease, with reference to reported application and/or study in dogs where available.
Baek
S J
SJ
Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Dr., Knoxville, TN 37996-4542, USA. sbaek2@utk.edu
McEntee
M F
MF
Legendre
A M
AM
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D018890:Chemoprevention / Q000379:methods / Q000662:veterinary*; D051545:Cyclooxygenase 1 / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism; D019587:Dietary Supplements; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D051766:Early Growth Response Protein 1 / Q000378:metabolism; D008024:Ligands; D015394:Molecular Structure; D009369:Neoplasms / Q000517:prevention & control / Q000662:veterinary*; D047495:PPAR gamma / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D051766:Early Growth Response Protein 1; D008024:Ligands; D047495:PPAR gamma; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2