title: Isolation of antibabesial compounds from Brucea javanica, Curcuma xanthorrhiza, and Excoecaria cochinchinensis.
abstract: One new curcuminoid, 3'-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1-4, and diminazene aceturate were studied with IC(50) values of 16.6, 7.6, 15.6, 10.0, and 0.6 microg/ml, respectively.
authors.affiliation: Laboratory of Bioorganic Chemistry, Division of Applied Bioscience, Research Faculty of Agriculture, Hokkaido University, Sapporo, Japan.
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Yamada
authors.lastname: Subeki
authors.forename: Kensuke
authors.initials: K
authors.lastname: Nabeta
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamasaki
authors.forename: Ken
authors.initials: K
authors.lastname: Katakura
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Matsuura
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001403:Babesia / Q000187:drug effects*; D032269:Brucea / Q000737:chemistry*; D030024:Curcuma / Q000737:chemistry*; D019665:Euphorbiaceae / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000981:Antiprotozoal Agents