title: Total synthesis of phomactin A.
abstract: A total synthesis of (+/-)-phomactin A is described to highlight the final completion of a complex natural product target that had commenced with an intramolecular oxa-[3 + 3] annulation strategy in the construction of the ABD-tricycle. These efforts reveal structural intricacies of this ABD-tricycle with an illustrative example being the conformational analysis that was ultimately critical for the C5a-homolgation.
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53705, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tang
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Cole
authors.forename: Grant S
authors.initials: GS
authors.lastname: Buchanan
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D001688:Biological Products; D006576:Heterocyclic Compounds, 4 or More Rings; C413206:phomactin A