title: Modulation of paracetamol and nefopam antinociception by serotonin 5-HT(3) receptor antagonists in mice.
abstract: OBJECTIVE
  Post-operative nausea and vomiting are common adverse events that require administration of anti-emetic compounds, such as the serotonin 5-HT(3) receptor antagonists, but these drugs can also reduce the analgesic efficacy of some analgesics (paracetamol, tramadol).
  
  
  METHODS
  The present study was designed to explore the effect of 3 serotonin 5-HT(3) receptor antagonists on the antinociceptive efficacy of another frequently used post-operative analgesic, nefopam, in the mouse writhing and formalin tests.
  
  
  RESULTS
  Pre-treatment with tropisetron, ondansetron or MDL72222 did not significantly modify nefopam antinociception in both tests. However, paracetamol antinociception was blocked by ondansetron in the formalin test.
  
  
  CONCLUSIONS
  These results provide a rationale for the clinical use of nefopam with anti-emetics during surgery.
authors.affiliation: Biocodex, Service de Pharmacologie, Compiègne, France.
authors.forename: Philippe
authors.initials: P
authors.lastname: Girard
authors.forename: Yannick
authors.initials: Y
authors.lastname: Pansart
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Coppé
authors.forename: Betty
authors.initials: B
authors.lastname: Niedergang
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Gillardin
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000494:pharmacology; D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009340:Nefopam / Q000008:administration & dosage / Q000494:pharmacology*; D017294:Ondansetron / Q000008:administration & dosage / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000077526:Tropisetron
chemical_list: D000700:Analgesics; D007211:Indoles; D058831:Serotonin 5-HT3 Receptor Antagonists; D012702:Serotonin Antagonists; D000082:Acetaminophen; D017294:Ondansetron; D009340:Nefopam; D000077526:Tropisetron; D019342:Acetic Acid