title: Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases.
abstract: OBJECTIVE
  To investigate the histologic features of the liver in nonalcoholic fatty liver disease (NAFLD) cases according to the presence of metabolic syndrome or its individual components.
  
  
  METHODS
  We enrolled 81 patients (40 male, 41 female) who were diagnosed with fatty liver by ultrasonographic scan and fulfilled the inclusion criteria. First anamnesis, anthropometric, clinical, laboratory and imaging features of all participants were recorded and then liver biopsy was performed after gaining consent from patients. Diagnosis of metabolic syndrome was dependent on patients having 3 or more out of 5 risk criteria defined by the WHO. Biopsy specimens were assessed according to Brunt et al's classification.
  
  
  RESULTS
  Sixty-nine of the 81 patients had nonalcoholic steatohepatitis (NASH), 11 had simple fatty liver and 1 had cirrhosis according to histologic evaluation. Comparisons were made between two groups of NASH patients, those with and without metabolic syndrome. We did not detect statistically significant differences in liver histology between NASH patients with and without metabolic syndrome.
  
  
  CONCLUSIONS
  NASH can progress without metabolic risk factors or the presence of metabolic syndrome.
authors.affiliation: Uludag University Medical School, Department of Gastroenterology, Bursa 16059, Turkey. huslusoy.23@hotmail.com
authors.forename: Hüseyin Saadettin
authors.initials: HS
authors.lastname: Uslusoy
authors.forename: Selim-Giray
authors.initials: SG
authors.lastname: Nak
authors.forename: Macit
authors.initials: M
authors.lastname: Gülten
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Biyikli
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D015992:Body Mass Index; D048909:Diabetes Complications / Q000473:pathology; D003920:Diabetes Mellitus / Q000473:pathology; D018450:Disease Progression; D005234:Fatty Liver / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000473:pathology*; D009765:Obesity / Q000453:epidemiology / Q000473:pathology; D012307:Risk Factors; D014463:Ultrasonography; D049629:Waist-Hip Ratio
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase