Can scavenger receptor Class B Type I loaded ultrasound contrast agent be a new method for treating atherosclerosis?
Nowadays, Ultrasound contrast agent (UCA) is not only a good contrast agent for ultrasonic imaging, but also an important tool for drug delivery. As a kind of UCA, lipofectamine has the shell with positive charge. It can encapsulate genes and also be adhered to cells because genes and cells are all with negative charge. With this feature, it plays an important role in transfection. Scavenger Receptor Class B Type I(SR-BI) is a HDL receptor thought to be the first step in the progress of cholesterol transport. In this way, SR-BI loaded UCA has great possibility to cure atherosclerosis plaque.
Jiang
Yeqing
Y
Department of Ultrasound in Medicine, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, 600 Yishan Rd, Shanghai 200233, China.
Zhu
Jiaan
J
Hu
Yizhou
Y
Xing
Chunyan
C
Li
Diancheng
D
Hu
Bing
B
D050197:Atherosclerosis / Q000188:drug therapy*; D003287:Contrast Media / Q000627:therapeutic use*; D006801:Humans; D008955:Models, Cardiovascular; D051124:Scavenger Receptors, Class C / Q000627:therapeutic use*; D014463:Ultrasonography / Q000379:methods
D003287:Contrast Media; D051124:Scavenger Receptors, Class C