title: Cerebral sinus thrombosis in a child with active ulcerative colitis and factor V Leiden.
abstract: Ulcerative colitis (UC) is a rare cause of cerebral sinus thrombosis. We describe a 10-year-old patient with UC who developed cerebral sinus thrombosis during an acute exacerbation of his colitis and was found to be heterozygous for factor V Leiden. He was successfully treated with enoxaparin. Enoxaparin was then used for prophylaxis during acute exacerbations of his UC without any recurrence/progression of cerebral venous thrombosis. This report describes a cerebral thrombotic event in a child with UC and factor V Leiden.
authors.affiliation: Division of Pediatric Hematology-Oncology, Department of Pediatrics, Childrens Hospital Los Angeles, Los Angeles, California 90027, USA. nrobison@chla.usc.edu
authors.forename: Nathan J
authors.initials: NJ
authors.lastname: Robison
authors.forename: Nickolas
authors.initials: N
authors.lastname: Dawlabani
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Lastra
authors.forename: Girish
authors.initials: G
authors.lastname: Dhall
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002648:Child; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy / Q000235:genetics; D017984:Enoxaparin / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D020767:Intracranial Thrombosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D017354:Point Mutation / Q000235:genetics*; D012851:Sinus Thrombosis, Intracranial / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin; C095381:factor V Leiden; D005165:Factor V