Multiple pilomatricomas and gliomatosis cerebri--a new association?
Pilomatricomas are benign skin tumors originating from hair follicle matrix cells. In 2% to 3.5% of cases they occur in multiplicity and then may be associated with genetic diseases, such as myotonic dystrophy Curschmann-Steinert, familial adenomatous polyposis (Gardner syndrome), and Rubinstein-Taybi syndrome. A 15-year-old boy treated with temozolomide and oxcarbazepine for gliomatosis cerebri with symptomatic epilepsy developed four firm cutaneous nodules on his face and right upper arm in the course of 1 year. All four tumors were excised under local anesthesia. Histological examination confirmed the clinical diagnosis of pilomatricomas. This is the first published case of a patient suffering from gliomatosis cerebri and developing multiple pilomatricomas. Whether this observation represents a new association or is a mere coincidence cannot be clarified at present.
Wachter-Giner
Tina
T
Department of Dermatology, University of Wuerzburg, Germany. giner_t@klinik.uni-wuerzburg.de
Bieber
Imke
I
Warmuth-Metz
Monika
M
Bröcker
Eva-B
EB
Hamm
Henning
H
D000293:Adolescent; D001706:Biopsy; D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology; D006201:Hair Diseases / Q000150:complications* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology; D018302:Neoplasms, Neuroepithelial / Q000150:complications* / Q000473:pathology; D018296:Pilomatrixoma / Q000150:complications* / Q000235:genetics / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications* / Q000235:genetics / Q000473:pathology