Expression of cyclooxygenase-1 in epithelial ovarian cancer: a clinicopathological study.
OBJECTIVE
To determine immunohistochemical expression of cyclooxygenase-1 (COX-1) in epithelial ovarian cancer (EOC), and its association with clinical features and prognosis.


METHODS
EOC patients treated in Bangkok Metropolitan Administration Medical College and Vajira Hospital during 1996-2003, and with available pathological tissue sections, were identified. Immunohistochemical staining was accomplished with antibodies to COX-1 and degree of expression was categorized into low and high for assessment of any. association with clinicopathological factors and survival.


RESULTS
One-hundred and seven patients were included in the study, with a median age of 50 years. Most had stage I and III disease. The most common histologic subtype was serous carcinoma. Overall, we found COX-1 expression in 83.2 %. Non-mucinous lesions had significant higher levels of expression than mucinous tumors, but there was no link expression with other clinicopathological factors or survival.


CONCLUSIONS
EOCs showed highexpression of COX-1, especially with a non-mucinous histology, but this appears to lack prognostic significance.
Khunnarong
Jakkapan
J
Department of Obstetrics and Gynecology, Bangkok Metropolitan Medical College and Vajira Hospital, Samsen Road, Dusit District, Bangkok, Thailand. jak020@hotmail.com
Tangjitgamol
Siriwan
S
Manusirivithaya
Sumonmal
S
Suekwattana
Pacheun
P
Leelahakorn
Surawute
S
D000328:Adult; D000367:Age Factors; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001707:Biopsy, Needle; D002277:Carcinoma / Q000201:enzymology* / Q000401:mortality / Q000473:pathology*; D015331:Cohort Studies; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D015588:Observer Variation; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology*; D011336:Probability; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D013785:Thailand
D014408:Biomarkers, Tumor; D051545:Cyclooxygenase 1