title: An integrated diffusion map for the analysis of diffusion properties: a feasibility study in patients with acoustic neuroma.
abstract: OBJECTIVE
  To develop an integrated diffusion map (iDM) for evaluation of diffusion properties, including the mean diffusivity and diffusion anisotropy concurrently.
  
  
  METHODS
  The proposed integrated diffusion map consisted of trace and the deviation tensor. It measures the diffusion distributions from a region of interest. Diffusion tensor imaging was acquired from nine healthy volunteers and four patients with acoustic neuroma before and 3 months after the stereotactic radiosurgery. Five regions of interest were selected from healthy subjects and the whole tumor from the patients. The diffusion properties were analyzed in the proposed integrated diffusion map.
  
  
  RESULTS
  In healthy subjects, iDM showed different distributions in regions of interest that can lead to cluster segmentation. In monitoring the treatment response, the number of pixels with meaningful changes in iDM is 12.5% compared to 32.37% in apparent diffusion coefficient and 16.67% in fractional anisotropy. It suggested the effect from radiation therapy might affect the anisotropic diffusion. The interpretation of the diffusion properties, such as changes in mean diffusivity and anisotropy, should be treated in an integrated method.
  
  
  CONCLUSIONS
  The integrated diffusion map can be used to analyze the diffusion properties in a comprehensive manner.
authors.affiliation: Department of Medical Imaging and Radiological Sciences, ChangGung Memorial Hospital, 5 FuHsing Street, TaoYuan County, KueiShan, Taiwan.
authors.forename: YauYau
authors.initials: Y
authors.lastname: Wai
authors.forename: JuHsu
authors.initials: J
authors.lastname: Chu
authors.forename: ChunChieh
authors.initials: C
authors.lastname: Wang
authors.forename: YuChun
authors.initials: Y
authors.lastname: Lin
authors.forename: Gigin
authors.initials: G
authors.lastname: Lin
authors.forename: YungLiang
authors.initials: Y
authors.lastname: Wan
authors.forename: JiunJie
authors.initials: J
authors.lastname: Wang
mesh_terms: D000465:Algorithms; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D009464:Neuroma, Acoustic / Q000175:diagnosis* / Q000601:surgery*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D018511:Systems Integration; D016896:Treatment Outcome; D055815:Young Adult