[Endothelium-dependent vascular smooth muscle relaxation and contraction].
Attempt is made to summarize an information concerning the participation of endotheliocytes in regulation of vascular smooth muscle tone. The role of main endothelium-dependent factors in relaxation and contraction of smooth muscles is analyzed. Particularly: the role of formed in endothelial cells nitric oxide, that is necessary for maintenance of the vascular vasodilatory tone. It is shown that in contrast to non cerebral vessels the effect of acetylcholine on endothelium-mediated relaxation of cerebral vessels is the matter of argument, but bradykinin unlike to acetylcholine causes significant endothelium-dependent smooth muscle relaxation, although so far it is not completely clear - either that is manifestation of physiological regulation, or it is relevant just to pathological conditions. The role of thrombin as activating agent of endothelium-dependent relaxation as well as endothelium-dependent action of vasopressin, and anoxic prevention of these effects are discussed.
Babiluri
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D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply; D002560:Cerebrovascular Circulation; D045462:Endothelium-Dependent Relaxing Factors / Q000378:metabolism*; D009130:Muscle, Smooth / Q000378:metabolism*; D051381:Rats; D017466:Receptors, Endothelin / Q000378:metabolism*; D013917:Thrombin / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism
D045462:Endothelium-Dependent Relaxing Factors; D017466:Receptors, Endothelin; D014667:Vasopressins; D013917:Thrombin; D000109:Acetylcholine