Advances in myogenic cell transplantation and skeletal muscle tissue engineering.
Curative treatments are currently not available for people suffering from one of the many prevalent muscle myopathies. One approach to ameliorate these conditions relies on the cell-based transplantation of potential myogenic precursors, or more optimistically, the transfer of engineered skeletal muscle tissue. To date, clinical trials with myogenic stem cell transplantation have met with only modest success while the transplantation of engineered muscle tissue is at the earliest stages of development. Despite the slow progress, these studies have provided insights and avenues that will eventually lead to a powerful therapeutic tool.
Scime
Anthony
A
Regenerative Medicine Program and Center for Stem Cell and Gene Therapy, Ottawa Health Research Institute, 501 Smyth Road, Ottawa, Ontario, Canada, K1H 8L6.
Caron
Annabelle Z
AZ
Grenier
Guillaume
G
D000818:Animals; D017690:Cell Transplantation; D051379:Mice; D018482:Muscle, Skeletal / Q000166:cytology*; D009135:Muscular Diseases / Q000628:therapy; D023822:Tissue Engineering