[Relationship between renal apparent diffusion coefficient and renal interstitial fibrosis: preliminary study].
OBJECTIVE
To explore the relationship between renal ADCs (apparent diffusion coefficient values) and renal interstitial fibrosis (RIF) grades.


METHODS
Twenty four patients with chronic renal diseases and 48 healthy volunteers (control group) were examined with SS-EPI DWI at 3. OT MR. In chronic renal disease group, RIF of 14 patients who received renal biopsy was determined as grade I and II based on the tubuleinterstitial damage degree, while RIF of 10 patients with uremia, who did not receive biopsy but had nephrogenic renal atrophy, was categorized as grade III.


RESULTS
With comparison of the study group and control group, ADCs of renal cortex were significantly different. In either grade II or III RIF, and ADCs of renal medulla showed difference in grade III RIF (P<0.05). Also, ADCs of both cortex and medulla displayed a decreasing trend as RIF grade increased (P<0.05).


CONCLUSIONS
ADCs of renal cortex and medulla may reflect the grades of RIF. ADC of renal cortex might be more sensitive than that of renal medulla.
Zhu
Jie
J
Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Zhou
Xiang-ping
XP
Liu
Rong-bo
RB
Fu
Ping
P
Hu
Zhang-xue
ZX
Ma
Ai-jing
AJ
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D005355:Fibrosis / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007672:Kidney Cortex / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000150:complications / Q000175:diagnosis*; D055815:Young Adult