title: Porous silicon biosensors on the advance.
abstract: Biosensor research is a rapidly expanding field with an immense market potential spanning a broad spectrum of applications including biomedical diagnostics, environmental monitoring, veterinary and food quality control. Porous silicon (pSi) is a nanostructured material poised to take centre stage in the biosensor development effort. This can be ascribed to the ease and speed of fabrication, remarkable optical and morphological properties of the material (including tuneable pore size and porosity), large internal surface area and the versatile surface chemistry. The past decade has, therefore, seen diverse proof-of-principle studies involving pSi-based optical and electrochemical transducers, which are highlighted here. We also provide comparative analysis of transducer sensitivity, robustness and susceptibility to interferences and cover strategies for sensitivity enhancement by means of signal amplification.
authors.affiliation: School of Chemistry, Physics and Earth Sciences, Flinders University, SA 5001, Australia.
authors.forename: Andrew
authors.initials: A
authors.lastname: Jane
authors.forename: Roman
authors.initials: R
authors.lastname: Dronov
authors.forename: Alastair
authors.initials: A
authors.lastname: Hodges
authors.forename: Nicolas H
authors.initials: NH
authors.lastname: Voelcker
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D016062:Porosity; D012680:Sensitivity and Specificity; D012825:Silicon / Q000737:chemistry*; D014159:Transducers
chemical_list: D012825:Silicon