Inhibitory effects of 6-(3-hydroxyphenyl)-2-naphthol on tyrosinase activity and melanin synthesis.
As a part of an ongoing project searching for new skin-lightening agents, the inhibitory property of 6-(3-Hydroxyphenyl)-2-naphthol (HPN) on melanogenesis was investigated. The inhibitory action of HPN (IC(50)=15.2 muM) on mushroom tyrosinase was revealed. To further explore the action of HPN on melanogenesis, the inhibition of tyrosinase and melanin levels were measured in B16 melanoma cells (B16 cells). Results show that HPN inhibited tyrosinase activity and reduced melanin in B16 cells. Therefore, our data indicate HPN as a new candidate for depigmentation reagents.
Chung
Sang Woon
SW
College of Pharmacy, Aging Tissue Bank, Pusan National University, Busan 609-735, Korea.
Ha
Young Mi
YM
Kim
You Jung
YJ
Song
Suhee
S
Lee
Hyojin
H
Suh
Hongsuk
H
Chung
Hae Young
HY
D000363:Agaricales / Q000201:enzymology; D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D008546:Melanoma, Experimental; D051379:Mice; D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D009284:Naphthols / Q000737:chemistry / Q000494:pharmacology*; D012880:Skin Pigmentation / Q000187:drug effects
C540204:6-(3-hydroxyphenyl)-2-naphthol; D008543:Melanins; D009284:Naphthols; D014442:Monophenol Monooxygenase