IQGAP1 regulation and roles in cancer.
IQGAP1 is a key mediator of several distinct cellular processes, in particular cytoskeletal rearrangements. Recent studies have implicated a potential role for IQGAP1 in cancer, supported by the over-expression and distinct membrane localisation of IQGAP1 observed in a range of tumours. IQGAP1 is thought to contribute to the transformed cancer cell phenotype by regulating signalling pathways involved in cell proliferation and transformation, weakening of cell:cell adhesion contacts and stimulation of cell motility and invasion. In this review we discuss these different functional and regulatory roles of IQGAP1 and its homologues in relation to their potential impact on tumourigenesis.
Johnson
Michael
M
Westmead Institute for Cancer Research, Westmead Millennium Institute at Westmead Hospital, University of Sydney, NSW 2145, Australia.
Sharma
Manisha
M
Henderson
Beric R
BR
D000818:Animals; D002448:Cell Adhesion; D002465:Cell Movement; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D023421:Models, Animal; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D015398:Signal Transduction; D020703:ras GTPase-Activating Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
C101203:IQ motif containing GTPase activating protein 1; D020703:ras GTPase-Activating Proteins