Local protein synthesis in axonal growth cones: what is next?
While initially thought to be essentially a developmental characteristic, observed in artificial in vitro models, local protein synthesis in growth cones has been described in the adult, and more interestingly, during nerve regeneration. This emerging field is under intense investigation, revealing new functions of localized protein synthesis that include axon guidance, growth cone adaptation and sensitivity modulation at intermediate targets or axon regeneration. Here, we will review these functions and provide a short survey of the current knowledge on mechanisms of mRNA transport and regulation of localized protein synthesis. In addition, we will consider what lessons can be learned from localized protein synthesis in dendrites, and what developments can be expected next in the field. This latter question relates to the crucial point of which technical strategy to adopt for an ideal and pertinent analysis of the phenomenon.
Satkauskas
Saulius
S
INSERM U575 Physiopathologie du Système Nerveux, Strasbourg, France.
Bagnard
Dominique
D
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D020439:Growth Cones / Q000378:metabolism*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D014176:Protein Biosynthesis / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D012038:Regeneration / Q000502:physiology*
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger