Glycine absorption in operative hysteroscopy: the impact of anesthesia.
OBJECTIVE
This study aimed to evaluate the impact of anesthesia on the absorption of glycine in operative hysteroscopy.


METHODS
A retrospective cohort study was performed over 2 years. The absorption of glycine was compared among general anesthesia, local anesthesia with intravenous sedation, and spinal anesthesia. Multiple logistic regression analyses were performed.


RESULTS
In all, 282 operative hysteroscopies were reviewed. The median absorption was 145 mL (10th-90th centile: 0-963 mL) for general anesthesia, 35 mL (10th-90th centile: 0-389 mL) for local anesthesia, and 100 mL (10th-90th centile: 0-500 mL) for spinal anesthesia (P = .002). In comparison with general anesthesia, local anesthesia was associated with lower rate of absorption of 500-1000 mL (4.2% vs 13.4%) and of 1000-1500 mL (3.6% vs 9.8; P = .002). Laparoscopic tubal ligation performed during the procedure was also associated with higher glycine absorption (odds ratio, 3.63; 95% confidence interval, 1.12-11.84).


CONCLUSIONS
Local anesthesia with sedation is associated with significantly decreased glycine absorption and lower rate of absorption > 500 mL when compared with general anesthesia.
Bergeron
Marie-Eve
ME
Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Québec, Faculty of Medicine, Université Laval, Québec City, QC, Canada.
Beaudet
Christine
C
Bujold
Emmanuel
E
Rhéaume
Caroline
C
Ouellet
Pascale
P
Laberge
Philippe
P
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D000772:Anesthesia, Local; D000775:Anesthesia, Spinal; D015331:Cohort Studies; D005260:Female; D005998:Glycine / Q000493:pharmacokinetics*; D006801:Humans; D015907:Hysteroscopy; D016015:Logistic Models; D008875:Middle Aged; D012189:Retrospective Studies; D014592:Uterine Hemorrhage / Q000601:surgery*
D005998:Glycine