Benzyne click chemistry with in situ generated aromatic azides.
An efficient synthesis of substituted benzotriazoles using an azide-alkyne 1,3-dipolar cycloaddition "click reaction" is described. Key to the procedure is the in situ generation of the reactive aromatic azide and benzyne reaction partners.
Zhang
Fengzhi
F
School of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, UK.
Moses
John E
JE
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000138:chemical synthesis / Q000737:chemistry; D001555:Benzene Derivatives / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
D000480:Alkynes; D001386:Azides; D001555:Benzene Derivatives; D014230:Triazoles; C524146:benzyne; C012771:benzotriazole