Angiographic follow-up of genous bioengineered stent in acute myocardial infarction (GENAMI)-a pilot study.
OBJECTIVE
GENAMI, an angiographic follow-up study was undertaken to evaluate the safety and efficacy of a new generation endothelial progenitor cell (EPC) capture stent, GENOUS during primary angioplasty for ST-elevation myocardial infarction (MI).


METHODS
Eleven consecutive patients with acute ST-elevation MI underwent primary percutaneous coronary intervention (PCI) using a bio-engineered GENOUS EPC stent.


RESULTS
Procedural success was 100%. Ten patients who survived underwent a follow-up angiography at 8 months. There was no instance of stent thrombosis during the follow-up period up to 12 months. The quantitative angiographic (quantitative coronary analysis [QCA]) follow-up data showed a late loss at 8 months of 0.97 +/- 0.94 mm and the late loss index was 44.35 +/- 40.47% with angiographic restenosis seen in 5 of 10 patients (50%). One of these patients with provocable ischemia underwent repeat PCI.


CONCLUSIONS
The QCA data of this study shows a high late loss with frequent angiographic restenosis during follow-up with this stent during primary PCI for acute STEMI. This observation, with important clinical implications, needs to be confirmed in larger studies.
Kaul
Upendra
U
Fortis Hospitals, Vasant Kunj and NOIDA. ukaul@vsnl.com
Bhatia
Vineet
V
Ghose
Tapan
T
Gupta
Ripen
R
Kachru
Ranjan
R
Singh
Gyanti
G
D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D023903:Coronary Restenosis / Q000517:prevention & control*; D003328:Coronary Thrombosis / Q000517:prevention & control; D042783:Endothelial Cells; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control / Q000601:surgery* / Q000628:therapy; D010865:Pilot Projects; D011446:Prospective Studies; D013234:Stem Cells; D015607:Stents