title: [Allergic contact dermatitis to cosmetics].
abstract: BACKGROUND
  Contact dermatitis to cosmetics is a common problem in the general population, although its prevalence appears to be underestimated. We reviewed cases of allergic contact dermatitis to cosmetics diagnosed in our dermatology department over a 7-year period with a view to identifying the allergens responsible, the frequency of occurrence of these allergens, and the cosmetic products implicated.
  
  
  METHODS
  Using the database of the skin allergy department, we undertook a search of all cases of allergic contact dermatitis to cosmetics diagnosed in our department from January 2000 through October 2007.
  
  
  RESULTS
  In this period, patch tests were carried out on 2,485 patients, of whom 740 were diagnosed with allergic contact dermatitis and the cause was cosmetics in 202 of these patients (170 women and 32 men), who accounted for 27.3 % of all cases. A total of 315 positive results were found for 46 different allergens. Allergens most often responsible for contact dermatitis in a cosmetics user were methylisothiazolinone (19 %), paraphenylenediamine (15.2 %), and fragrance mixtures (7.8 %). Acrylates were the most common allergens in cases of occupational disease. Half of the positive results were obtained with the standard battery of the Spanish Group for Research Into Dermatitis and Skin Allergies (GEIDAC). The cosmetic products most often implicated among cosmetics users were hair dyes (18.5 %), gels/soaps (15.7 %), and moisturizers (12.7 %).
  
  
  CONCLUSIONS
  Most patients affected were women. Preservatives, paraphenylenediamine, and fragrances were the most frequently detected cosmetic allergens, in line with previous reports in the literature. Finally, in order to detect new cosmetic allergens, cooperation between physicians and cosmetics producers is needed.
authors.affiliation: Servicio de Dermatología, Hospital General Universitario de Valencia, Valencia, España. cecipru@comv.es
authors.forename: C
authors.initials: C
authors.lastname: Laguna
authors.forename: J
authors.initials: J
authors.lastname: de la Cuadra
authors.forename: B
authors.initials: B
authors.lastname: Martín-González
authors.forename: V
authors.initials: V
authors.lastname: Zaragoza
authors.forename: L
authors.initials: L
authors.lastname: Martínez-Casimiro
authors.forename: V
authors.initials: V
authors.lastname: Alegre
mesh_terms: D000180:Acrylic Resins / Q000009:adverse effects; D000485:Allergens / Q000009:adverse effects*; D001505:Beauty Culture; D003358:Cosmetics / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000453:epidemiology / Q000209:etiology; D004643:Emollients / Q000009:adverse effects; D005260:Female; D006203:Hair Preparations / Q000009:adverse effects; D006801:Humans; D008297:Male; D010476:Perfume / Q000009:adverse effects; D010655:Phenylenediamines / Q000009:adverse effects; D012189:Retrospective Studies; D012915:Soaps / Q000009:adverse effects; D013030:Spain / Q000453:epidemiology; D013844:Thiazoles / Q000009:adverse effects
chemical_list: D000180:Acrylic Resins; D000485:Allergens; D003358:Cosmetics; D004643:Emollients; D006203:Hair Preparations; D010476:Perfume; D010655:Phenylenediamines; D012915:Soaps; D013844:Thiazoles; C011506:2-methyl-4-isothiazolin-3-one; C029728:4-phenylenediamine