title: Synthesis of actin-depolymerizing compounds.
abstract: The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.
authors.affiliation: Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kitamura
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Teruya
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kuroda
authors.forename: Hideo
authors.initials: H
authors.lastname: Kigoshi
authors.forename: Kiyotake
authors.initials: K
authors.lastname: Suenaga
mesh_terms: D000199:Actins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D012694:Serine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity
chemical_list: D000199:Actins; D007783:Lactones; D018942:Macrolides; C104057:aplyronine A; D012694:Serine