Mitochondrial NADH-dehydrogenase subunit 3 (ND3) polymorphism (A10398G) and sporadic breast cancer in Poland.
Mitochondria are subcellular organelles that produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). As suggested over 70 years ago by Otto Warburg and recently confirmed with molecular techniques, alterations in respiratory activity and mitochondrial DNA (mtDNA) appear to be common features of malignant cells. Somatic mtDNA mutations have been reported in many types of cancer cells, but very few reports document the prevalence of inherited mitochondrial DNA polymorphisms in cancer patients compared to healthy control populations. Here we report the abundance of the 10398G polymorphism in a Polish breast cancer population and its frequency in controls. Amongst individuals with breast cancer the G single nucleotide polymorphism (SNP) is present in 23% of affected females compared to 3% of controls. This difference is highly statistically significant (P = 0.0008). It is therefore possible that the 10398G SNP constitutes an inherited predisposition factor for the development of breast cancer.
Czarnecka
Anna M
AM
Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul Pawińskiego 5a, 02-106 Warsaw, Poland.
Krawczyk
Tomasz
T
Zdrozny
Marek
M
Lubiński
Jan
J
Arnold
Rebecca S
RS
Kukwa
Wojciech
W
Scińska
Anna
A
Golik
Paweł
P
Bartnik
Ewa
E
Petros
John A
JA
D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D042967:Electron Transport Complex I / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D011044:Poland; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
D042967:Electron Transport Complex I; C114961:MT-ND3 protein, human