[Mental retardation as a risk factor to develop a psychotic disease].
BACKGROUND
One of the main aims of research on schizophrenia has been to pinpoint the early symptoms and signals of the disease before its appearance.


OBJECTIVE
We have examined the diagnoses previously given to patients before they were diagnosed of schizophrenia.


METHODS
This is a case-control study in which we used a data register including the fields of minimum basic data set (MBDS) whose time period included 1999 to 2005.


RESULTS
In our study, there was a 3.6% frequency of mental retardation and 2.1% one of behavioral and emotional disorders with onset usually occurring in childhood and adolescence, both diagnosed previously. The estimated odds ratio for a mentally retarded patient to suffer adult onset psychosis is 4.6 (95%CI [3.43-6.26]), schizophrenia 5.8 (95% CI [4.20-7.88]), paranoid schizophrenia 4.8 (95% CI [3.39 -6.93]), residual schizophrenia 7.0 (95% CI [4.81 -10.09]) and persistent delusional disorder 2.7 (95% CI [1.57 -4.73]).


CONCLUSIONS
It can be concluded from our study that there is an increased frequency of mental retardation among the pathological records of subjects who will be diagnosed with paranoid schizophrenia and residual schizophrenia in the future. This fact supports the etiological thesis of schizophrenia involving neurodevelopment disorders.
López
M Negueruela
MN
Fundación Jiménez Díaz, Madrid, Spain.
Domíngeuz
A Ceverino
AC
Quintero
J
J
Rodríguez
M M Pérez
MM
Fernández Del Moral
A
A
Arriero
M A Jiménez
MA
Vigo
M Martínez
MM
Villamor
I Basurte
IB
Vicente
M J Sevilla
MJ
Castromán
J López
JL
Jiménez
R Navarro
RN
Zambrano-Enríquez
D
D
González de Rivera
J L
JL
García
E Baca
EB
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008607:Intellectual Disability / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012559:Schizophrenia / Q000453:epidemiology / Q000209:etiology*; D055815:Young Adult