title: Impact of AV conduction disorders on SafeR mode performance.
abstract: OBJECTIVE
  CAN-SAVE R is a Canadian multicenter study that compares the effects of a new pacing mode algorithm designed to minimize right ventricular (V) pacing versus DDD mode with a long atrioventricular (AV) delay in a general population of pacemaker (PM) recipients.
  
  
  METHODS
  Patients with permanent atrial fibrillation (AF) or high-degree AV block (AVB) were excluded. We present preliminary data collected in 208 patients (mean age=71 +/- 11 years, 68% men), for the 2-month baseline period during which all PM were programmed in the new pacing mode. The pacing indications were sinus node disease (SND) without AVB in 39%, AVB without SND in 30%, SND and AVB in 16%, and miscellaneous in 15% of patients.
  
  
  RESULTS
  The mean percent V pacing in the overall population was 9.5 +/- 23.8% (range=0-100%, median <1%), ranging between 0.5 +/- 1.5% (median=0) in patients without AVB and 18.7 +/- 31.2% in patients (median = 1) with AVB. Adverse events potentially related to the new pacing mode were observed in two patients with AVB.
  
  
  CONCLUSIONS
  A new pacing mode was effective and safe in a general population of PM recipients without permanent AVB and was associated with an overall <1% median V pacing. CAN-SAVE R will compare the long-term effects of the new pacing mode with DDD with a long AV delay on clinical outcomes and cardiac function.
authors.affiliation: Montreal Heart Institute, Montreal, Quebec, Canada. ablation2000@videotron.ca
authors.forename: Bernard
authors.initials: B
authors.lastname: Thibault
authors.forename: Christopher
authors.initials: C
authors.lastname: Simpson
authors.forename: Carl-Eric
authors.initials: CE
authors.lastname: Gagné
authors.forename: Louis
authors.initials: L
authors.lastname: Blier
authors.forename: Manohara
authors.initials: M
authors.lastname: Senaratne
authors.forename: Serge
authors.initials: S
authors.lastname: McNicoll
authors.forename: Carlo
authors.initials: C
authors.lastname: Stuglin
authors.forename: Randy
authors.initials: R
authors.lastname: Williams
authors.forename: Arnold
authors.initials: A
authors.lastname: Pinter
authors.forename: Yaariv
authors.initials: Y
authors.lastname: Khaykin
authors.forename: Remi
authors.initials: R
authors.lastname: Nitzsche
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000453:epidemiology* / Q000517:prevention & control*; D054537:Atrioventricular Block / Q000453:epidemiology* / Q000517:prevention & control*; D002170:Canada; D002304:Cardiac Pacing, Artificial / Q000706:statistics & numerical data*; D015897:Comorbidity; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D016896:Treatment Outcome