title: What happens to the thymus in children who have undergone a median sternotomy?
abstract: BACKGROUND
  The thymus grows rapidly during fetal life and continues to grow during childhood. When a child undergoes a median sternotomy during cardiac surgery, most of the thymus is removed to gain access to the mediastinum. What happens to the residual thymic tissue in the long term?
  
  
  OBJECTIVE
  To test the hypothesis that residual thymic tissue left after sternotomy regenerates into an identifiable thymus and is visible on MRI.
  
  
  METHODS
  We retrospectively reviewed the cardiac MR images obtained over a 14-month period in all children under the age of 17 years who had undergone a median sternotomy (n=62) to establish the presence/absence of a thymus. We also reviewed the cardiac MR images obtained over the same time period in children who had never undergone open cardiac surgery (n=37).
  
  
  RESULTS
  In the sternotomy group, 18 patients (29%) had an identifiable thymus on MR images, compared to 92% (n=34) in the nonsternotomy group. This difference was statistically significant.
  
  
  CONCLUSIONS
  The majority of children in the study group did not have a visible thymus on MR images, which suggests that in these children any residual thymic tissue left postoperatively does not regenerate.
authors.affiliation: Department of Paediatric Radiology, Bristol Royal Hospital for Children, Bristol, UK. agatha@doctors.org.uk
authors.forename: Kelly
authors.initials: K
authors.lastname: MacDonald
authors.forename: Stephanie
authors.initials: S
authors.lastname: Mackenzie
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D013249:Sternum / Q000473:pathology* / Q000601:surgery*; D013950:Thymus Gland / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome