The basic science of bone induction.
The last few decades of basic science research have provided an increased understanding of the role of osteogenic glycoproteins in bone formation. The isolation of such molecules now permits de novo orthotopic induction with increasing evidence of the ability to also induce bone growth in heterotopic sites. The current editorial focuses on the basic science of bone induction with two subsequent issues dedicated to the translation of these principles into both animal subjects and human clinical applications.
Heliotis
Manolis
M
North West London Regional Maxillofacial Unit, Northwick Park Hospital, London, United Kingdom.
Ripamonti
Ugo
U
Ferretti
Carlo
C
Kerawala
Cyrus
C
Mantalaris
Athanasios
A
Tsiridis
Eleftherios
E
D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D006801:Humans; D009999:Ossification, Heterotopic / Q000503:physiopathology; D010012:Osteogenesis / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology; D055411:TGF-beta Superfamily Proteins / Q000502:physiology; D023822:Tissue Engineering; D054457:Tissue Scaffolds
D019485:Bone Morphogenetic Proteins; D055411:TGF-beta Superfamily Proteins