title: Chemokines and chemokine receptors: an overview.
abstract: Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling activity. Here we analyze the chemokine system, with particular attention to available information on clinical situations in which chemokines or their receptors might assume diagnostic value.
authors.affiliation: Department of Translational Medicine, University of Milan, IRCCS Istituto Clinico Humanitas, I-20089 Rozzano, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Galliera
authors.forename: Elena Monica
authors.initials: EM
authors.lastname: Borroni
authors.forename: Massimiliano Marco
authors.initials: MM
authors.lastname: Corsi
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
mesh_terms: D000818:Animals; D018925:Chemokines / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D019707:Receptors, Chemokine / Q000502:physiology*
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine