Term pregnancy with intraperitoneal levonorgestrel intrauterine system: a case report and review of the literature.
BACKGROUND
The risk of adverse effects of fetal exposure to the levonorgestrel intrauterine system (LNG-IUS) has not been established.


METHODS
In this case report and literature review, we describe a pregnant patient with an intraperitoneal LNG-IUS and the subsequent maternal and neonatal outcomes. A systematic literature search was performed to identify similar clinical reports. The MEDLINE, EMBASE, Cochrane Database of Systematic Reviews, CENTRAL, Web of Science and Scopus databases were searched from inception through March 2007.


RESULTS
The pregnancy progressed uneventfully and culminated in the elective cesarean delivery of a full-term healthy boy. Of the 35 pregnancies identified in the literature review (34 pregnancies with intrauterine LNG-IUS and 1 term delivery with intraperitoneal LNG-IUS), congenital anomalies were reported in 2 infants (6%).


CONCLUSIONS
Fetal exposure to LNG-IUS is associated with a low frequency of congenital anomalies.
Hopkins
Matthew R
MR
Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA. hopkins.matthew@mayo.edu
Agudelo-Suarez
Patricia
P
El-Nashar
Sherif A
SA
Creedon
Douglas J
DJ
Rose
Carl H
CH
Famuyide
Abimbola O
AO
D000328:Adult; D002585:Cesarean Section; D005260:Female; D005548:Foreign-Body Migration; D006801:Humans; D007231:Infant, Newborn; D007436:Intrauterine Devices, Medicated; D016912:Levonorgestrel; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome
D016912:Levonorgestrel