Immunohistochemical and histopathological evaluation of 2,4-dichlorophenoxyacetic acid-induced changes in rat kidney cortex.
This study aims to investigate the effect of 2,4-dichlorophenoxyacetic acid (2,4-D) on rat kidney cortex histology. Oral exposure of rats to 2,4-D for 28 days resulted in decreases in body weight gain and kidney weight. Histological examination showed degeneration in renal corpuscles and podocytes; vacuolization in the glomerulus with disintegration of the basal membrane; tissue edema; vacuolization, cystic dilation and invagination of the basal laminae in the tubular structures; dilation and congestion in renal corpuscular vessels and marked decrease in glomerular and stromal fibronectin reaction; suggesting that subacute 2,4-D administration induces dose-dependent histopathological degenerative effects in rat kidney cortex.
Uyanikgil
Yiğit
Y
Faculty of Medicine, Department of Histology and Embryology, Ege University, 35100, Bornova, Izmir, Turkey. yigit.uyanikgil@ege.edu.tr
Ateş
Utku
U
Baka
Meral
M
Biçer
Songül
S
Oztaş
Ebru
E
Ergen
Gürsel
G
D015084:2,4-Dichlorophenoxyacetic Acid / Q000633:toxicity*; D000818:Animals; D006540:Herbicides / Q000633:toxicity*; D007150:Immunohistochemistry; D007672:Kidney Cortex / Q000737:chemistry / Q000187:drug effects* / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D036401:Toxicity Tests, Chronic
D006540:Herbicides; D015084:2,4-Dichlorophenoxyacetic Acid