title: Mechanistic insights into Bardet-Biedl syndrome, a model ciliopathy.
abstract: Bardet-Biedl syndrome (BBS) is a multisystemic disorder typified by developmental and progressive degenerative defects. A combination of genetic, in vitro, and in vivo studies have highlighted ciliary dysfunction as a primary cause of BBS pathology, which has in turn contributed to the improved understanding of the functions of the primary cilium in humans and other vertebrates. Here we discuss the evidence linking the clinical BBS phenotype to ciliary defects, highlight how the genetic and cellular characteristics of BBS overlap with and inform other ciliary disorders, and explore the possible mechanistic underpinnings of ciliary dysfunction.
authors.affiliation: McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Norann A
authors.initials: NA
authors.lastname: Zaghloul
authors.forename: Nicholas
authors.initials: N
authors.lastname: Katsanis
mesh_terms: D000818:Animals; D020788:Bardet-Biedl Syndrome / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D002874:Chromosome Mapping; D002923:Cilia / Q000473:pathology; D002925:Ciliary Motility Disorders / Q000235:genetics; D006801:Humans; D009765:Obesity / Q000235:genetics; D010641:Phenotype; D017689:Polydactyly / Q000235:genetics; D015995:Prevalence; D012164:Retinal Diseases / Q000235:genetics; D014714:Vertebrates