title: Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia.
abstract: Matrix metalloproteinase-9 (MMP-9) plays a role in many pathological conditions (e.g. cancer and heart disease). Recently, MMP-9 has been implicated in the activity of the prefrontal cortex and we therefore hypothesized that the MMP-9 gene may be associated with schizophrenia. We genotyped the functional -1562C/T polymorphism in a group of 442 schizophrenia patients and in 558 healthy control subjects. A significant preponderance of C/C genotype and C allele was found in the schizophrenia subjects compared to healthy controls. The results may provide the first evidence for involvement of the MMP-9 gene in the pathogenesis of schizophrenia and could also contribute to explaining a genetic connection between schizophrenia and some somatic illnesses.
authors.affiliation: Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. rybakows@wlkp.top.pl
authors.forename: Janusz K
authors.initials: JK
authors.lastname: Rybakowski
authors.forename: Maria
authors.initials: M
authors.lastname: Skibinska
authors.forename: Pawel
authors.initials: P
authors.lastname: Kapelski
authors.forename: Leszek
authors.initials: L
authors.lastname: Kaczmarek
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D020780:Matrix Metalloproteinase 9