Estimating the lipophilicity of a number of 2-amino-1-cyclohexanol derivatives exhibiting anticonvulsant activity.
The lipophilicity of a number of N-acyl derivatives of trans- or cis-: racemic, (1R,2R)- or (1S,2S)-aminocyclohexanol (1-13) exhibiting anticonvulsant activity was investigated. Their lipophilicity (R(m0)) was determined using reversed-phase thin-layer chromatography (RP-TLC) with mixtures of methanol and water as mobile phases. The partition coefficients of compounds 1-13 (log P) were also calculated using two computer programs (Pallas and Chem DU) and compared with R(m0).
Pekala
Elzbieta
E
Department of Technology and Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Cracow, Poland. mfpekala@cyf-kr.edu.pl
Marona
Henryk
H
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer / Q000379:methods*; D003511:Cyclohexanols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007536:Isomerism; D008055:Lipids / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D051379:Mice; D014867:Water / Q000737:chemistry
C516358:2-aminocyclohexanol; D000927:Anticonvulsants; D003511:Cyclohexanols; D008055:Lipids; D014867:Water; D000432:Methanol