title: Pharmacokinetics of intracameral voriconazole injection.
abstract: Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-microg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis. A rapid decline in intracameral concentration suggests that frequent supplementation of intracameral voriconazole may be required in clinical settings.
authors.affiliation: Department of Ophthalmology, Taichung Veterans General Hospital, No. 160, Section 3, Taichung Harbor Road, Taichung, Taiwan, Republic of China.
authors.forename: Ying-Cheng
authors.initials: YC
authors.lastname: Shen
authors.forename: Mei-Yen
authors.initials: MY
authors.lastname: Wang
authors.forename: Chun-Yuan
authors.initials: CY
authors.lastname: Wang
authors.forename: Tsun-Chung
authors.initials: TC
authors.lastname: Tsai
authors.forename: Hin-Yeung
authors.initials: HY
authors.lastname: Tsai
authors.forename: Hsin-Nung
authors.initials: HN
authors.lastname: Lee
authors.forename: Li-Chen
authors.initials: LC
authors.lastname: Wei
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D006207:Half-Life; D007267:Injections; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D014230:Triazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014822:Vitreous Body / Q000378:metabolism*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole