Validation of continuous glucose monitoring in children and adolescents with cystic fibrosis: a prospective cohort study.
OBJECTIVE
To validate continuous glucose monitoring (CGM) in children and adolescents with cystic fibrosis.


METHODS
Paired oral glucose tolerance tests (OGTTs) and CGM monitoring was undertaken in 102 children and adolescents with cystic fibrosis (age 9.5-19.0 years) at baseline (CGM1) and after 12 months (CGM2). CGM validity was assessed by reliability, reproducibility, and repeatability.


RESULTS
CGM was reliable with a Bland-Altman agreement between CGM and OGTT of 0.81 mmol/l (95% CI for bias +/- 2.90 mmol/l) and good correlation between the two (r = 0.74-0.9; P < 0.01). CGM was reproducible with no significant differences in the coefficient of variation of the CGM assessment between visits and repeatable with a mean difference between CGM1 and CGM2 of 0.09 mmol/l (95% CI for difference +/- 0.46 mmol/l) and a discriminant ratio of 13.0 and 15.1, respectively.


CONCLUSIONS
In this cohort of children and adolescents with cystic fibrosis, CGM performed on two occasions over a 12-month period was reliable, reproducible, and repeatable.
O'Riordan
Stephen M P
SM
National Children's Hospital, Tallaght, Dublin, Ireland. s.oriordan@ich.ucl.ac.uk
Hindmarsh
Peter
P
Hill
Nathan R
NR
Matthews
David R
DR
George
Sherly
S
Greally
Peter
P
Canny
Gerard
G
Slattery
Dubhfeasa
D
Murphy
Nuala
N
Roche
Edna
E
Costigan
Colm
C
Hoey
Hilary
H
D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000097:blood*; D048909:Diabetes Complications / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D008297:Male; D018670:Monitoring, Ambulatory / Q000379:methods*; D008991:Monitoring, Physiologic / Q000379:methods*; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
D001786:Blood Glucose