title: Prevalence of left main coronary artery disease among patients with ischemic heart disease: insights from the Tehran Angiography Registry.
abstract: OBJECTIVE
  This study was designed to investigate the prevalence of left main coronary artery (LMCA) significant stenosis among patients with stable angina (SA) or acute coronary syndromes (ACSs) and to assess the influence of demographic and clinical profiles on these findings.
  
  
  METHODS
  A review of the Angiography Registry demonstrated that 18137 patients had SA or ACSs. The patients' characteristics were compared in subgroups with and without LMCA disease.
  
  
  RESULTS
  Significant and minimal LMCA stenoses were found in 659 (3.6%) and 1157 (6.4%) patients, respectively. An unprotected LMCA disease was estimated in 609 (3.4%) subjects. A cumulative Logit Model analysis revealed the male gender (odds ratio [OR]=1.480, 95% confidence interval [CI]=1.287 to 1.703; P<0.001), diabetes mellitus (OR=1.158, 95% CI=1.029 to 1.303; P=0.015), dyslipidemia (OR=1.125, 95% CI=1.001 to 1.265; P=0.048), and aging (OR=1.028, 95% CI=1.022 to 1.034; P<0.001) as the independent predictors of LMCA stenosis with coexistent diseases in the rest of the coronary arteries. In the patients with normal or minimal stenoses of the other coronary arteries, cigarette smoking (OR=3.749, 95% CI=1.698 to 8.070) was found to be the independent risk factor of isolated LMCA disease. Luminal stenosis >50% in the right coronary artery, the left circumflex artery, and the left anterior descending artery was significantly more frequent in association with LMCA disease.
  
  
  CONCLUSIONS
  The patients with LMCA disease were more likely to be male, older, and have diabetes mellitus or dyslipidemia, whereas cigarette smoking was found as an independent predictor of isolated LMCA. There was a strong correlation between the severity of LMCA stenosis and coexistent diseases in the rest of the coronary arteries.
authors.affiliation: Department of Research, Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: A
authors.initials: A
authors.lastname: Soleimani
authors.forename: A
authors.initials: A
authors.lastname: Abbasi
authors.forename: E H
authors.initials: EH
authors.lastname: Kazzazi
authors.forename: K
authors.initials: K
authors.lastname: Hosseini
authors.forename: M
authors.initials: M
authors.lastname: Salirifar
authors.forename: S
authors.initials: S
authors.lastname: Darabian
authors.forename: S
authors.initials: S
authors.lastname: Sadeghian
authors.forename: M
authors.initials: M
authors.lastname: Sheikhfathol-Lahi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003324:Coronary Artery Disease / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D048909:Diabetes Complications / Q000453:epidemiology; D050171:Dyslipidemias / Q000150:complications; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008499:Medical Records / Q000706:statistics & numerical data*; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000453:epidemiology; D016017:Odds Ratio; D015995:Prevalence; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects