Placental pathology in egg donor pregnancies.
OBJECTIVE
To determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies.


METHODS
Retrospective case-control study.


METHODS
Academic medical center.


METHODS
The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation.


METHODS
None.


METHODS
Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry.


RESULTS
There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group.


CONCLUSIONS
There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon.
Gundogan
Fusun
F
Department of Pathology, Women and Infants Hospital101 Dudley St. Providence, Rhode Island 02905, USA. fgundogan@wihri.org
Bianchi
Diana W
DW
Scherjon
Sicco A
SA
Roberts
Drucilla J
DJ
D015703:Antigens, CD / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006680:HLA Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000276:immunology / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology*; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D015703:Antigens, CD; D006680:HLA Antigens; D015236:HLA-C Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I