title: Reproductive performance in oocyte donors and their recipients: comparative analysis from implantation to birth and lactation.
abstract: OBJECTIVE
  To compare reproductive performance among pregnancies initiated with autologous oocytes and donated oocytes.
  
  
  METHODS
  Retrospective cohort analysis.
  
  
  METHODS
  Clínica las Condes Hospital, a tertiary referral center in Chile; Fertility, Centro de Fertilizaçao Assistida, Brazil; and 130 institutions reporting to the Latin American Registry (RLA) of assisted reproductive technologies (ART).
  
  
  METHODS
  Cohort 1 evaluates 70 women who conceived during an IVF cycle, and simultaneously donated fresh oocytes to other 70 oocyte recipients who also conceived. Cohort 2 evaluates the follow-up of 31,550 pregnancies after IVF and 6,024 pregnancies in oocyte recipients, both reported to the RLA between 1995 and 2005.
  
  
  METHODS
  ART with autologous and donor oocytes.
  
  
  METHODS
  Embryo implantation rate, weight of newborns, gestational age at delivery, perinatal mortality and duration of lactation.
  
  
  RESULTS
  Oocyte donors and their recipients share similar embryo implantation rate, weight of newborns, gestational age at delivery, perinatal mortality, and duration of lactation.
  
  
  CONCLUSIONS
  The establishment of pregnancy is as efficient with autologous as with donated oocytes. Embryos transferred into their progenitors or in different women have similar chances of implantation, weight at birth, and perinatal outcome. Embryo implantation is affected by the age of the recipient, suggesting that uterine senescence plays a role in fecundity.
authors.affiliation: Reproductive Medicine Unit, Clínica Las Condes, Santiago, Chile. fzegers@clc.cl
authors.forename: Fernando
authors.initials: F
authors.lastname: Zegers-Hochschild
authors.forename: Diego
authors.initials: D
authors.lastname: Masoli
authors.forename: Juan-Enrique
authors.initials: JE
authors.lastname: Schwarze
authors.forename: Assumpto
authors.initials: A
authors.lastname: Iaconelli
authors.forename: Edson
authors.initials: E
authors.lastname: Borges
authors.forename: Isabel M
authors.initials: IM
authors.lastname: Pacheco
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004526:Efficiency; D010064:Embryo Implantation / Q000502:physiology*; D004624:Embryo Transfer / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007774:Lactation / Q000502:physiology; D008875:Middle Aged; D018587:Oocyte Donation / Q000706:statistics & numerical data*; D036801:Parturition / Q000502:physiology; D011247:Pregnancy; D018873:Pregnancy Rate; D012098:Reproduction / Q000502:physiology; D027724:Reproductive Techniques, Assisted / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013997:Time Factors; D014019:Tissue Donors / Q000706:statistics & numerical data*; D055815:Young Adult