title: Recurrent fever and rash.
abstract: Periodic fever is uncommon in children. The differential diagnosis is large, even though associated symptoms such as rash may help narrow the differential diagnosis. Atypical presentations require thoughtful evaluation. This article describes a case of a 4-year-old boy who presented to the emergency department with recurrent fever, vomiting, abdominal pain, myalgias, and rash. His hospital course is described along with a review on the background, evaluation, management, and complications of tumor necrosis receptor-1 alpha periodic syndrome.
authors.affiliation: Carman and Adams Department of Pediatrics, Children's Hospital of Michigan, Detroit, Michigan, USA.
authors.forename: Katherine
authors.initials: K
authors.lastname: Cashen
authors.forename: Deepak
authors.initials: D
authors.lastname: Kamat
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005076:Exanthema / Q000209:etiology*; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005334:Fever / Q000209:etiology*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications; D008297:Male; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood; D016896:Treatment Outcome; D014839:Vomiting / Q000209:etiology
chemical_list: D018124:Receptors, Tumor Necrosis Factor