Synthesis and characterization of copolymers of methylmethacrylate and 2-hydroxyethyl methacrylate for the aqueous solubilization of Paclitaxel.
The aim of the present work is the modification of a hydrophobic polymeric macromolecule, polymethylmethacrylate, by introducing hydrophilic moieties of 2-hydroxyethyl methacrylate within the polymer chain. Synthesis, characterization, and drug delivery control capabilities exerted on a highly hydrophobic drug (Paclitaxel) are illustrated. In particular, the dependency of the drug delivery kinetic on the fraction of hydrophilic units inserted in the copolymer chain was studied. Results showed that it is possible to have an increase of the kinetic delivery introducing hydrophilic units. In addition, a double control, diffusive and due to the relaxation of the molecules, on drug delivery was obtained.
Silvestri
Davide
D
Department of Chemical Engineering, Industrial Chemistry and Materials Science, University of Pisa, Pisa, Italy.
Gagliardi
Mariacristina
M
Barbani
Niccoletta
N
Cristallini
Caterina
C
Giusti
Paolo
P
D000465:Algorithms; D001682:Biological Availability; D002152:Calorimetry, Differential Scanning; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D020366:Methylmethacrylate / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013057:Spectrum Analysis; D013818:Thermogravimetry; D044366:Transition Temperature; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D008689:Methacrylates; D011108:Polymers; D014867:Water; D020366:Methylmethacrylate; C005044:hydroxyethyl methacrylate; D017239:Paclitaxel