Stability of cough linctus (streptol) formulated from named medicinal plant extracts.
Extracts of named medicinal herbs (Garcinia kola, Zingiber oificinale, Aframonum melequeta and Ocimum viride) were formulated into an antitussive preparation to alleviate cough. Some physical properties of the cough syrup formulation evaluated were: specific gravity, pH, viscosity, content uniformity, and shelf life. The specific gravity and viscosity of the formulations were stable on storage, with glycerin-based formulations having higher values. The pH of the formulation varied from 4.2 to 5.3 and was also stable on storage. Glycerin-based formulations had lower pH values. The total flavonoids content of Streptol was calculated based on GB1 and found to be 46 mg. The estimated shelf life of the Streptol cough syrup was 4.5 years.
Iwu
Maurice
M
International Centre for Ethno Medicine and Drug Discovery (InterCEDD), Nsukka, Enugu State Nigeria.
Okunji
Christopher
C
Tchimene
Michel
M
Anele
Ngozi
N
Chah
Kennedy
K
Osonwa
Uduma
U
Akpa
Paul Achile
PA
Onunkwo
Godswill Chukwunweike
GC
D000996:Antitussive Agents / Q000737:chemistry* / Q000494:pharmacology; D002626:Chemistry, Pharmaceutical; D005419:Flavonoids / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013012:Sorbitol / Q000737:chemistry; D013046:Specific Gravity; D013696:Temperature; D014783:Viscosity
D000996:Antitussive Agents; D005419:Flavonoids; D010936:Plant Extracts; D013012:Sorbitol; D005990:Glycerol