Parvovirus b19 infection localized in the intestinal mucosa and associated with severe inflammatory bowel disease.
Infection by human parvovirus B19 is widespread and can be associated with a wide range of different pathologies and clinical manifestations. We provide the first evidence of localization of an active parvovirus B19 infection in the intestinal mucosa and its association with a severe inflammatory bowel disease, characterized by duodenal villous atrophy with increased intraepithelial lymphocytes and inflammatory infiltrates in the colonic mucosa. Virus in the intestinal mucosa was detected in cells of the inflammatory infiltrate, identified as T lymphocytes and selectively localized in sites of active tissue degeneration.
Pironi
Loris
L
Department of Internal Medicine and Gastroenterology, Center for Chronic Intestinal Failure, University of Bologna, S Orsola-Malpighi Hospital, Bologna, Italy.
Bonvicini
Francesca
F
Gionchetti
Paolo
P
D'Errico
Antonia
A
Rizzello
Fernando
F
Corsini
Catia
C
Foroni
Laura
L
Gallinella
Giorgio
G
D003106:Colon / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D007413:Intestinal Mucosa / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications* / Q000473:pathology* / Q000821:virology; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D013601:T-Lymphocytes / Q000821:virology