title: Decreased IgA antibody production in the stomach of gastric adenocarcinoma patients.
abstract: Gastric adenocarcinoma is closely associated with Helicobacter pylori infection. It is also much more frequent in patients with common variable immunodeficiency or selective IgA-deficiency than in the general population. To investigate a possible link between local antibody production and gastric tumors, we studied gastric B cell infiltration and local IgA production in patients with H. pylori induced gastric adenocarcinomas. These studies showed that total and H. pylori-specific IgA antibody levels were substantially lower in gastric tissue from the cancer patients compared to those from asymptomatic H. pylori carriers. However, serum IgA levels were similar in the cancer patients and asymptomatic carriers. As could be expected, H. pylori infected asymptomatic carriers had considerably increased IgA antibody levels compared to uninfected subjects. We conclude that patients suffering from gastric adenocarcinoma have a dramatically decreased local IgA production in the stomach compared to asymptomatic H. pylori infected individuals.
authors.affiliation: Department of Microbiology and Immunology and Gothenburg University Vaccine Research Institute (GUVAX), Institute of Biomedicine, The Sahlgrenska Academy at University of Gothenburg, Sweden. marianne.quiding@microbio.gu.se
authors.forename: Marianne
authors.initials: M
authors.lastname: Quiding-Järbrink
authors.forename: Patrik
authors.initials: P
authors.lastname: Sundström
authors.forename: Anna
authors.initials: A
authors.lastname: Lundgren
authors.forename: Malin
authors.initials: M
authors.lastname: Hansson
authors.forename: Malin
authors.initials: M
authors.lastname: Bäckström
authors.forename: Camilla
authors.initials: C
authors.lastname: Johansson
authors.forename: Karin
authors.initials: K
authors.lastname: Enarsson
authors.forename: Michael
authors.initials: M
authors.lastname: Hermansson
authors.forename: Erik
authors.initials: E
authors.lastname: Johnsson
authors.forename: Ann-Mari
authors.initials: AM
authors.lastname: Svennerholm
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000382:microbiology; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000276:immunology*; D016481:Helicobacter Infections / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D013274:Stomach Neoplasms / Q000276:immunology* / Q000382:microbiology; D014510:Urease / Q000276:immunology / Q000378:metabolism
chemical_list: D000907:Antibodies, Bacterial; D018925:Chemokines; D007070:Immunoglobulin A; D014510:Urease