Gradient-index lens rod based probe for office-based optical coherence tomography of the human larynx.
Optical coherence tomography (OCT) is an evolving noninvasive imaging modality that has been used to image the human larynx during surgical endoscopy. The design of a long gradient-index lens-based probe capable of capturing images of the human larynx by use of spectral domain OCT during a typical office-based laryngoscopy examination is presented. An optical-ballast-based 4f optical relay system is proposed to realize variable working distance with a constant optical delay. In-vivo OCT imaging of the human larynx is demonstrated. Office-based OCT is a promising imaging modality for early laryngeal cancer diagnosis.
Guo
Shuguang
S
University of California, Irvine, Department of Biomedical Engineering, Irvine, California 92697, USA.
Yu
Lingfeng
L
Sepehr
Ali
A
Perez
Jorge
J
Su
Jianping
J
Ridgway
James M
JM
Vokes
David
D
Wong
Brian J F
BJ
Chen
Zhongping
Z
D000553:Ambulatory Care / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007830:Larynx / Q000033:anatomy & histology*; D007909:Lenses; D012031:Refractometry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation*