New cytotoxic phenolic derivatives from matured fruits of Magnolia denudata.
Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.
Noshita
Toshiro
T
Department of Clinical Pharmacy, Aomori University, Kohbata, Aomori, Japan. noshita@aomori-u.ac.jp
Kiyota
Hiromasa
H
Kidachi
Yumi
Y
Ryoyama
Kazuo
K
Funayama
Shinji
S
Hanada
Ken
K
Murayama
Tetsuya
T
D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D005638:Fruit / Q000737:chemistry* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry* / Q000254:growth & development; D019800:Phenol / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*
D019800:Phenol