Zeolite catalyzed solvent-free one-pot synthesis of dihydropyrimidin-2(1H)-ones--a practical synthesis of monastrol.
A zeolite-catalyzed, simple, one-pot, solvent-free, cost effective, and environmentally benign process for the synthesis of dihydropyrimidones is described. This reaction is scaleable to multigram scale and the catalyst is recyclable. This methodology has resulted in an efficient synthesis of monastrol, a potent inhibitor of kinesin Eg5.
Kulkarni
Mukund G
MG
Department of Chemistry, University of Pune, Ganeshkhind, Pune 411007, Maharashtra, India. mgkulkarni@chem.unipune.ernet.in
Chavhan
Sanjay W
SW
Shinde
Mahadev P
MP
Gaikwad
Dnyaneshwar D
DD
Borhade
Ajit S
AS
Dhondge
Attrimuni P
AP
Shaikh
Yunnus B
YB
Ningdale
Vijay B
VB
Desai
Mayur P
MP
Birhade
Deekshaputra R
DR