title: Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the chinese mangrove plant Rhizophora mucronata.
abstract: Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A-F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.
authors.affiliation: Institut fur Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universitat, Dusseldorf, Germany.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Julia
authors.initials: J
authors.lastname: Kjer
authors.forename: Jandirk
authors.initials: J
authors.lastname: Sendker
authors.forename: Victor
authors.initials: V
authors.lastname: Wray
authors.forename: Huashi
authors.initials: H
authors.lastname: Guan
authors.forename: Ruangelie
authors.initials: R
authors.lastname: Edrada
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Peter
authors.initials: P
authors.lastname: Proksch
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D043982:Rhizophoraceae / Q000382:microbiology*; D013098:Xylariales / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002867:Chromones; D004365:Drugs, Chinese Herbal