Role of autophagy in mammary gland development.
Autophagy is a highly conserved catabolic process responsible for degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway, together with proteasome system is particularly important during development and under certain environmental stress conditions. This review summarizes the latest achievements of studies aiming to explore the role of autophagy in development and differentiation of eukaryotic cells. It shows the importance of this process in the development of lower eukaryotic organisms such as Dicyostelium discoideum, and Caenorhabditis elegans, as well as functions of autophagy and autophagy related genes (Atg) in development and differentiation of higher eukaryotic organisms. The review is focused on the results of studies conducted on mammary gland, as it is a good model for studying the mechanisms controlling higher eukaryotic organisms' development. Studies have shown that autophagy is involved in the removal of epithelial cells during formation of alveolar structures, indicating its role in mammogenesis. There are also evidences of involvement of Atg's in epithelial tumors development. Context dependent manipulations of autophagic pathways may create more effective anticancer therapies in the future.
Gajewska
M
M
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences, Poland. gajewska_knf@yahoo.pl
Sobolewska
A
A
Kozlowski
M
M
Motyl
T
T
D000818:Animals; D001343:Autophagy / Q000235:genetics; D001943:Breast Neoplasms / Q000503:physiopathology; D002454:Cell Differentiation; D004847:Epithelial Cells / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D008321:Mammary Glands, Animal / Q000254:growth & development* / Q000378:metabolism; D042361:Mammary Glands, Human / Q000254:growth & development* / Q000378:metabolism; D015674:Mammary Neoplasms, Animal / Q000503:physiopathology