Effects of subchronic phencyclidine on behaviour of female rats on the elevated plus maze and open field.
Female hooded-Lister rats received either subchronic phencyclidine (PCP) (2 mg/kg, n = 20) or vehicle (1 ml/kg, n = 20) intraperitoneally twice daily for 7 days, followed by a 7-day washout period. Rats were challenged with acute PCP or vehicle and tested for locomotor activity to ensure hyperactivity was observed in the subchronic PCP-treated rats. Rats were then tested on the elevated plus maze and in an open field for 10 min. Subchronic PCP did not significantly affect behaviour on the elevated plus maze or in the open field. In conclusion, subchronic PCP does not induce anxiety-like behaviour.
McLean
S L
SL
Bradford School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK.
Woolley
M L
ML
Neill
J C
JC
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001522:Behavior, Animal / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects*; D005260:Female; D006948:Hyperkinesis / Q000139:chemically induced; D009043:Motor Activity / Q000187:drug effects; D010622:Phencyclidine / Q000008:administration & dosage / Q000633:toxicity*; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013997:Time Factors
D011619:Psychotropic Drugs; D016194:Receptors, N-Methyl-D-Aspartate; D010622:Phencyclidine