title: Placental pathology in egg donor pregnancies.
abstract: OBJECTIVE
  To determine placental pathology and immune response at the maternal-fetal interface in pregnancies conceived by IVF via egg donation compared with nondonor IVF pregnancies.
  
  
  METHODS
  Retrospective case-control study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  The study population included 20 egg donor and 33 nondonor IVF pregnancies of >24 weeks' gestation.
  
  
  METHODS
  None.
  
  
  METHODS
  Perinatal complications (gestational hypertension, abruption, preterm delivery, cesarean section), microscopic features indicating an immune response and trophoblast damage, and characterization of inflammatory cells using immunohistochemistry.
  
  
  RESULTS
  There was an increase in gestational hypertension and preterm delivery in egg donor pregnancies. Dense fibrinoid deposition in the basal plate with severe chronic deciduitis containing significantly increased numbers of T helper and natural killer cells were demonstrated in egg donor placentas. Trophoblast damage was also increased in the preterm egg donor group.
  
  
  CONCLUSIONS
  There are significant histological and immunohistochemical differences between the placentas of egg donor and nondonor IVF pregnancies. The increased immune activity and fibrinoid deposition at the maternal-fetal interface of egg donor pregnancies could represent a host versus graft rejection-like phenomenon.
authors.affiliation: Department of Pathology, Women and Infants Hospital101 Dudley St. Providence, Rhode Island 02905, USA. fgundogan@wihri.org
authors.forename: Fusun
authors.initials: F
authors.lastname: Gundogan
authors.forename: Diana W
authors.initials: DW
authors.lastname: Bianchi
authors.forename: Sicco A
authors.initials: SA
authors.lastname: Scherjon
authors.forename: Drucilla J
authors.initials: DJ
authors.lastname: Roberts
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006680:HLA Antigens / Q000032:analysis; D015236:HLA-C Antigens / Q000032:analysis; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000276:immunology / Q000473:pathology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology*; D012189:Retrospective Studies; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D015703:Antigens, CD; D006680:HLA Antigens; D015236:HLA-C Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I