title: Prenatal diagnosis of transient abnormal myelopoiesis in a Down syndrome fetus.
abstract: We report a case of transient abnormal myelopoiesis in a Down syndrome fetus diagnosed at 28(+3) weeks of gestation that rapidly progressed to intrauterine death 10 days later. Fetal hepatosplenomegaly with cerebral ventriculomegaly, although not specific, may be a suggestive finding of Down syndrome with transient abnormal myelopoiesis. Prompt fetal blood sampling for liver function test and chromosomal analysis are mandatory for early detection and management.
authors.affiliation: Department of Obstetric and Gynecology, Chung-Ang University School of Medicine, Seoul, Korea.
authors.forename: Gwang Jun
authors.initials: GJ
authors.lastname: Kim
authors.forename: Eun Sil
authors.initials: ES
authors.lastname: Lee
mesh_terms: D000328:Adult; D004314:Down Syndrome / Q000000981:diagnostic imaging*; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D005313:Fetal Death; D005315:Fetal Diseases / Q000175:diagnosis*; D006529:Hepatomegaly / Q000000981:diagnostic imaging; D006801:Humans; D007964:Leukocytosis / Q000175:diagnosis; D038042:Myelopoiesis; D011247:Pregnancy; D011296:Prenatal Diagnosis; D013163:Splenomegaly / Q000000981:diagnostic imaging; D013921:Thrombocytopenia / Q000175:diagnosis; D014463:Ultrasonography