The side story of stem-like glioma cells.
In this issue of Cell Stem Stell, Bleau et al. report that activity of the drug transporter ABCG2 defines a tumorigenic stem-like side population (SP) isolated from glioma. Surprisingly, temozolomide, the first-line chemotherapeutic used for treatment of glioma, increased this side population, and even more so when PTEN was deleted.
Persson
Anders I
AI
Department of Neurology, University of California, San Francisco, San Francisco, CA 94143, USA. anders.persson@ucsf.edu
Weiss
William A
WA
D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000378:metabolism*; D001932:Brain Neoplasms / Q000378:metabolism*; D003606:Dacarbazine / Q000031:analogs & derivatives* / Q000378:metabolism; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism*; D014411:Neoplastic Stem Cells / Q000378:metabolism*; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D000077204:Temozolomide
C116614:ABCG2 protein, human; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; C501412:Abcg2 protein, mouse; D018906:Antineoplastic Agents, Alkylating; D009363:Neoplasm Proteins; D003606:Dacarbazine; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D051059:PTEN Phosphohydrolase; D000077204:Temozolomide