Epicardial control of myocardial proliferation and morphogenesis.
The epicardium is a critical tissue that directs several aspects of heart development, particularly via the secretion of soluble factors. This review summarizes recent approaches that implicate the epicardium as the source of mitogenic factors promoting cardiomyocyte proliferation, as the source of instructive signals that direct compact zone organization (morphogenesis), and as the tissue that directs formation of the coronary vasculature.
Sucov
Henry M
HM
Institute for Genetic Medicine, University of Southern California Keck School of Medicine, 2250 Alcazar St., IGM240, Los Angeles, CA 90033, USA. sucov@usc.edu
Gu
Ying
Y
Thomas
Simmy
S
Li
Peng
P
Pashmforoush
Mohammad
M
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D049109:Cell Proliferation; D003331:Coronary Vessels / Q000196:embryology; D006133:Growth Substances; D006321:Heart / Q000196:embryology*; D051379:Mice; D009206:Myocardium; D032383:Myocytes, Cardiac / Q000502:physiology; D010496:Pericardium / Q000196:embryology*; D015398:Signal Transduction
D006133:Growth Substances