title: Dependence of pharmacokinetics and biodistribution on polymer architecture: effect of cyclic versus linear polymers.
abstract: The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable molecular weight.
authors.affiliation: Department of Biopharmaceutical Sciences, School of Pharmacy, University of California, 513 Parnassus Avenue, San Francisco, California 94143-0912, USA.
authors.forename: Norased
authors.initials: N
authors.lastname: Nasongkla
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Nichole
authors.initials: N
authors.lastname: Macaraeg
authors.forename: Megan E
authors.initials: ME
authors.lastname: Fox
authors.forename: Jean M J
authors.initials: JM
authors.lastname: Fréchet
authors.forename: Francis C
authors.initials: FC
authors.lastname: Szoka
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D006207:Half-Life; D051379:Mice; D008968:Molecular Conformation; D008970:Molecular Weight; D010599:Pharmacokinetics; D011108:Polymers / Q000737:chemistry* / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D001672:Biocompatible Materials; D011108:Polymers