title: Antiulcerogenic activity of the essential oil of Baccharis dracunculifolia on different experimental models in rats.
abstract: Baccharis dracunculifolia DC (Asteraceae), a native plant from Brazil, commonly known as 'Alecrimdo-campo' is widely used in folk medicine to treat inflammation, hepatic disorders and stomach ulcers, and it is the most important botanical source of Southeastern Brazilian propolis, known as green propolis. Its essential oil is composed of non-oxygenated and oxygenated terpenes. In this work, the effects of the essential oil obtained from the aerial parts of B. dracunculifolia on gastric ulcers were evaluated. The antiulcer assays were undertaken using the following protocols in rats: nonsteroidal antiinflammatory drug (NSAID)-induced ulcer, ethanol-induced ulcer, stress-induced ulcer, and determination of gastric secretion using ligated pylorus. The treatment in the doses of 50, 250 and 500 mg/kg of B. dracunculifolia essential oil significantly diminished the lesion index, the total lesion area and the percentage of lesions in comparison with both positive and negative control groups. With regard to the model of gastric secretion a reduction of gastric juice volume and total acidity was observed, as well as an increase in the gastric pH. No sign of toxicity was observed in the acute toxicity study. Considering the results, it is suggested that the essential oil of B. dracunculifolia could probably be a good therapeutic agent for the development of new phytotherapeutic medicine for the treatment of gastric ulcer.
authors.affiliation: Núcleo de Ciência e Tecnologia, Area de Ciências Biológicas e da Saúde, Universidade do Oeste de Santa Catarina, Videira, SC, Brazil.
authors.forename: Juliane Jose
authors.initials: JJ
authors.lastname: Massignani
authors.forename: Marivane
authors.initials: M
authors.lastname: Lemos
authors.forename: Edson Luis
authors.initials: EL
authors.lastname: Maistro
authors.forename: Hamilton Pedro
authors.initials: HP
authors.lastname: Schaphauser
authors.forename: Renata Fabiane
authors.initials: RF
authors.lastname: Jorge
authors.forename: João Paulo Barreto
authors.initials: JP
authors.lastname: Sousa
authors.forename: Jairo Kennup
authors.initials: JK
authors.lastname: Bastos
authors.forename: Sérgio Faloni
authors.initials: SF
authors.lastname: de Andrade
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D031175:Baccharis / Q000737:chemistry*; D004195:Disease Models, Animal; D000431:Ethanol; D005750:Gastric Juice / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D009822:Oils, Volatile / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013270:Stomach / Q000187:drug effects*; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology; D013315:Stress, Psychological
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D009822:Oils, Volatile; D010936:Plant Extracts; D000431:Ethanol