Clinicopathological features of patients with bronchial-associated lymphoid tissue lymphoma.
OBJECTIVE
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) type is the most frequent type of non-Hodgkin's lymphoma to primarily involve the lung. Pulmonary MALT lymphoma, also known as bronchial-associated lymphoid tissue (BALT) lymphoma, is a rare disease and the clinicopathological features have yet to be clearly elucidated.


METHODS
The present study retrospectively reviewed 13 patients (8 men, 5 women) with BALT lymphoma from 3 institutions between 1989 and 2007 to assess clinicopathological features.


RESULTS
At diagnosis, the median age was 61.6 years (range, 37-80 years), and 11 patients were asymptomatic while 2 had non-specific pulmonary symptoms. Two patients had a history of Sjögren's syndrome. Computed tomography of the chest revealed bilateral disease in 7 patients, lung nodules in 8 patients and air space consolidation with or without air bronchogram in 5 patients. In all cases, disease was localized within the lung at the initial diagnosis. Of the 13 patients, 5 remain untreated, while 8 received various combinations of treatment (surgery alone in 6 patients, surgery plus chemotherapy in 1 patient, and radiotherapy alone in 1 patient). Twelve patients remained alive during the median follow-up of 31.3 months (range, 2-147 months), while 1 patient died from unknown causes.


CONCLUSIONS
The present study indicates that BALT lymphoma tends to be limited to the lung on the initial diagnosis and responds well to local therapy such as surgery. Prognosis for this lymphoma tends to be indolent.
Imai
Hisao
H
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Maebashi. imaih@med.gunma-u.ac.jp
Sunaga
Noriaki
N
Kaira
Kyoichi
K
Kawashima
Osamu
O
Yanagitani
Noriko
N
Sato
Koji
K
Tomizawa
Yoshio
Y
Hisada
Takeshi
T
Ishizuka
Tamotsu
T
Hirato
Junko
J
Saito
Ryusei
R
Nakajima
Takashi
T
Mori
Masatomo
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004358:Drug Therapy; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011878:Radiotherapy; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome