Idiopathic hypogonadotropic hypogonadism in selective human gonadotropin deficiency in adult man: a case report.
We report a rare case of idiopathic hypogonadotropic hypogonadism in an adult male (31-year-old), who underwent an endocrinological examination because of erectile dysfunction and suspected infertility. Laboratory data showed isolated gonadotropin deficiency. Magnetic resonance imaging (MRI) of the hypothalamic-pituitary unit showed no tumoral expansions. The patient was tested with gonadotropin releasing hormone (Gn-RH) (100 microg as an i.v. bolus injection). No significant LH and FSH responses were observed. Idiopathic hypogonadotropic hypogonadism is usually caused by hypothalamic lesions, however, since Gn-RH was unable to stimulate LH and FSH secretions, we supposed that our patient was affected by defective gonadotropin secretion at pituitary level.
Volpi
Riccardo
R
Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy. riccardo.volpi@unipr.it
Ugolotti
Maria Chiara
MC
Carbucicchio
Andrea
A
Delsignore
Roberto
R
D000328:Adult; D000728:Androgens / Q000627:therapeutic use; D007172:Erectile Dysfunction / Q000209:etiology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013739:Testosterone / Q000627:therapeutic use
D000728:Androgens; D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone