Liver histology according to the presence of metabolic syndrome in nonalcoholic fatty liver disease cases.
OBJECTIVE
To investigate the histologic features of the liver in nonalcoholic fatty liver disease (NAFLD) cases according to the presence of metabolic syndrome or its individual components.


METHODS
We enrolled 81 patients (40 male, 41 female) who were diagnosed with fatty liver by ultrasonographic scan and fulfilled the inclusion criteria. First anamnesis, anthropometric, clinical, laboratory and imaging features of all participants were recorded and then liver biopsy was performed after gaining consent from patients. Diagnosis of metabolic syndrome was dependent on patients having 3 or more out of 5 risk criteria defined by the WHO. Biopsy specimens were assessed according to Brunt et al's classification.


RESULTS
Sixty-nine of the 81 patients had nonalcoholic steatohepatitis (NASH), 11 had simple fatty liver and 1 had cirrhosis according to histologic evaluation. Comparisons were made between two groups of NASH patients, those with and without metabolic syndrome. We did not detect statistically significant differences in liver histology between NASH patients with and without metabolic syndrome.


CONCLUSIONS
NASH can progress without metabolic risk factors or the presence of metabolic syndrome.
Uslusoy
Hüseyin Saadettin
HS
Uludag University Medical School, Department of Gastroenterology, Bursa 16059, Turkey. huslusoy.23@hotmail.com
Nak
Selim-Giray
SG
Gülten
Macit
M
Biyikli
Zeynep
Z
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001706:Biopsy; D015992:Body Mass Index; D048909:Diabetes Complications / Q000473:pathology; D003920:Diabetes Mellitus / Q000473:pathology; D018450:Disease Progression; D005234:Fatty Liver / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000473:pathology*; D009765:Obesity / Q000453:epidemiology / Q000473:pathology; D012307:Risk Factors; D014463:Ultrasonography; D049629:Waist-Hip Ratio
D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase