Highly efficient synthesis of aldenamines from carboxamides by iridium-catalyzed silane-reduction/dehydration under mild conditions.
The combination of IrCl(CO)(PPh3)2 with 1,1,3,3-tetramethyldisiloxane or poly(methylhydrosiloxane) (PMHS) is found to be an efficient catalyst system for the preparation of aldenamines from carboxamides; in particular, facile removal of silicone and iridium residues from the product can be achieved by the use of PMHS.
Motoyama
Yukihiro
Y
Institute for Materials Chemistry and Engineering, Kyushu University, Kasuga, Fukuoka 816-8580, Japan.
Aoki
Masaharu
M
Takaoka
Naoki
N
Aoto
Ryuta
R
Nagashima
Hideo
H