title: Breast cancer, estrogen receptor and ligands.
abstract: This review emphasizes the relationship of breast cancer, estrogen receptor and ligands, especially the centrality of the estrogen receptor, which mediates on one hand the hormone-induced gene transcription and on the other hand the anti-estrogen action against breast cancer. The characterization of the estrogen receptor ligand-binding domain co-crystallized with agonists or antagonists provided a molecular basis to gain an insight into the regulation of estrogen receptor and, thereby, to describe the mechanism of the hormone therapy in treating breast cancer.
authors.affiliation: Institute of Pharmacy, Freie Universität Berlin, Knigin-Luise-Strasse 2 + 4, Berlin, Germany.
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Bai
authors.forename: Ronald
authors.initials: R
authors.lastname: Gust
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000209:etiology; D004965:Estrogen Antagonists; D005260:Female; D006801:Humans; D008024:Ligands; D011960:Receptors, Estrogen / Q000737:chemistry / Q000187:drug effects* / Q000235:genetics; D020845:Selective Estrogen Receptor Modulators; D014158:Transcription, Genetic
chemical_list: D004965:Estrogen Antagonists; D008024:Ligands; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators