title: [Fluoroquinolones: antimicrobial activity and chemotherapeutic efficacy with respect to various pathogens in highly dangerous diseases].
abstract: Comparative in vitro and in vivo efficacy of new fluoroquinolones with respect to pathogens of tularemia, glanders, melioidosis and anthrax was estimated. It was shown that the strains of the tularemia, glanders, melioidosis and anthrax pathogens were in vitro highly susceptible to the new agents. The experiments on laboratory animals demonstrated that pefloxacin and sparfloxacin had extremely broad spectra and were of special value in emergency prophylaxis of tularemia, glanders, melioidosis and anthrax.
authors.forename: T A
authors.initials: TA
authors.lastname: Bondareva
authors.forename: V B
authors.initials: VB
authors.lastname: Kalininskiĭ
authors.forename: I V
authors.initials: IV
authors.lastname: Borisevich
authors.forename: V P
authors.initials: VP
authors.lastname: Bondarev
authors.forename: V V
authors.initials: VV
authors.lastname: Kozhukhov
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Amosov
authors.forename: G V
authors.initials: GV
authors.lastname: Baramzina
authors.forename: O O
authors.initials: OO
authors.lastname: Fomenkov
authors.forename: F V
authors.initials: FV
authors.lastname: Krinitsyn
mesh_terms: D000818:Animals; D000881:Anthrax / Q000188:drug therapy* / Q000382:microbiology; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001408:Bacillus anthracis / Q000187:drug effects; D016957:Burkholderia pseudomallei / Q000187:drug effects; D006224:Cricetinae; D024841:Fluoroquinolones / Q000494:pharmacology* / Q000627:therapeutic use; D005604:Francisella tularensis / Q000187:drug effects; D005896:Glanders / Q000188:drug therapy* / Q000382:microbiology; D006168:Guinea Pigs; D008554:Melioidosis / Q000188:drug therapy* / Q000382:microbiology; D008647:Mesocricetus; D014406:Tularemia / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones