Mononuclear Cu(II)-phenolate bioinspired complex is catalytically promiscuous: phosphodiester and peptide amide bond cleavage.
In this work, the cleavage activity of the metal complex [Cu(C(21)H(21)N(3)O(2))(OH(2))(2)](2+) is demonstrated to occur toward double-stranded DNA, in addition to its previously described amide bond cleavage activity, thus suggesting catalytic promiscuity for this complex.
Oliveira
Mauricio C Bof
MC
Centro de Biologia Molecular Estrutural, Departamento de Bioquímica, Universidade Federal de Santa Catarina, 88040-900 Florianópolis-SC, Brazil.
Mazera
Deise
D
Scarpellini
Marciela
M
Severino
Patricia Cardoso
PC
Neves
Ademir
A
Terenzi
Hernán
H
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004247:DNA / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009942:Organometallic Compounds / Q000737:chemistry*; D010755:Organophosphates / Q000737:chemistry*; D009994:Osmolar Concentration; D010455:Peptides / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D010957:Plasmids / Q000737:chemistry; D013696:Temperature
D000577:Amides; D009942:Organometallic Compounds; D010755:Organophosphates; D010455:Peptides; D010636:Phenols; D003300:Copper; D004247:DNA