title: Identification of autoantibody against beta-amyloid peptide in the serum of elderly.
abstract: Alzheimer's disease (AD) is characterized by two major neurological features: amyloid deposits and neurofibrillary tangles in the brain. According to the amyloid cascade hypothesis, accumulation of amyloid-beta peptide (A-beta) plays a central role in the pathogenesis of AD. Several lines of evidence suggest that antibodies against A-beta play a protective role in the neuropathology of AD. In this study, we describe the purification of an autoantibody against A-beta from human serum using affinity purification method. The purified autoantibody recognized A-beta deposits in the brain of aged Tg2676 mice, an animal model of AD. The serum levels of anti-A-beta autoantibody correlated inversely with age in both AD patients and control non-demented elderly subjects. Furthermore, the levels were significantly lower in AD patients compared with the age-matched control subjects. It is the first time to show the identification of endogenous anti-A-beta autoantibody in human serum and suggesting that serum levels of anti-A-beta autoantibody might be a good biomarker for AD patients.
authors.affiliation: University College of Medicine, Seoul, 110-799, Korea.
authors.forename: Ji-Hoon
authors.initials: JH
authors.lastname: Sohn
authors.forename: Jung On
authors.initials: JO
authors.lastname: So
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Hong
authors.forename: Jong Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Duk Ryul
authors.initials: DR
authors.lastname: Na
authors.forename: Manho
authors.initials: M
authors.lastname: Kim
authors.forename: Hee
authors.initials: H
authors.lastname: Kim
authors.forename: Eunjoo
authors.initials: E
authors.lastname: Nam
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Ha
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Inhee
authors.initials: I
authors.lastname: Mook-Jung
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016229:Amyloid beta-Peptides / Q000276:immunology*; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D008875:Middle Aged
chemical_list: D016229:Amyloid beta-Peptides; D001323:Autoantibodies