title: Computer controlled sequential simulation method: reconsidering evaluation of measurements from frequently sampled intravenous glucose tolerance test.
abstract: This work describes quantification of regulatory mechanisms glucose-insulin, using data from a frequently sampled intravenous glucose tolerance test (FSIVGTT) and a mechanistically motivated model with time delays. FSIVGTT was performed on 14 young healthy volunteers. The constructed model computationally takes into account the form of the short-time glucose infusion used. Estimated model parameters are used to derive relationships quantifying the following mechanisms of regulatory systems glucose-insulin of the volunteers enrolled: (1) glucose uptake by body cells; (2) cessation (suppression) of glucose output from liver; (3) glucose clearance. The model presented correctly approximates initial peaks and subsequent waves in plasma glucose concentration-time profiles after the glucose infusion. These results indicate that the model presented is an appropriate tool for assessing glucose behavior during a FSIVGTT.
authors.affiliation: Faculty of Mechanical Engineering, Institute of Automation, Measurement and Applied Informatics, Slovak University of Technology, Bratislava, Slovak Republic. ladislav.dedik@stuba.sk
authors.forename: Ladislav
authors.initials: L
authors.lastname: Dedík
authors.forename: Martina
authors.initials: M
authors.lastname: Tvrdonová
authors.forename: Mária
authors.initials: M
authors.lastname: Durisová
authors.forename: Adela
authors.initials: A
authors.lastname: Penesová
authors.forename: Daniela
authors.initials: D
authors.lastname: Miklovicová
authors.forename: Marián
authors.initials: M
authors.lastname: Kozlovský
mesh_terms: D000328:Adult; D001786:Blood Glucose; D019295:Computational Biology / Q000379:methods*; D003627:Data Interpretation, Statistical; D005260:Female; D005951:Glucose Tolerance Test / Q000379:methods; D006801:Humans; D007328:Insulin / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D015233:Models, Statistical; D008962:Models, Theoretical; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D012984:Software
chemical_list: D001786:Blood Glucose; D007328:Insulin