title: Synthesis and antiviral evaluation of thieno[3,4-d]pyrimidine C-nucleoside analogues of 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-adenosine and -inosine.
abstract: Several thieno[3,4-d]pyrimidine derivatives, including four hitherto unknown 2',3'-dideoxy- and 2',3'-dideoxy-2',3'-didehydro-C-nucleoside analogues of adenosine and inosine have been synthesized. When evaluated in cell culture experiments against human immunodeficiency virus, none of the tested compounds exhibited any significant antiviral effect, while two of them showed some cytotoxicity.
authors.affiliation: Idenix Pharmaceuticals, Medicinal Chemistry Laboratories IDENIX Sarl, Cap Gamma, 1682 rue de la Valsière, 34189 Montpellier Cedex 4, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Hamann
authors.forename: Claire
authors.initials: C
authors.lastname: Pierra
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Sommadossi
authors.forename: Chiara
authors.initials: C
authors.lastname: Musiu
authors.forename: Luana
authors.initials: L
authors.lastname: Vargiu
authors.forename: Michel
authors.initials: M
authors.lastname: Liuzzi
authors.forename: Richard
authors.initials: R
authors.lastname: Storer
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects; D007288:Inosine / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000998:Antiviral Agents; D011743:Pyrimidines; D007288:Inosine; D000241:Adenosine