title: Effect of culprit-lesion remodeling versus plaque rupture on three-year outcome in patients with acute coronary syndrome.
abstract: To investigate intravascular ultrasound predictors of long-term clinical outcome in patients with acute coronary syndrome, 94 patients with a first acute coronary syndrome with both preintervention intravascular ultrasound imaging and long-term follow-up were enrolled in this study. Remodeling index was defined as external elastic membrane cross-sectional area at the target lesion divided by that at the proximal reference. Arterial remodeling was defined as either positive (PR: remodeling index >1.05) or intermediate/negative remodeling (remodeling index < or =1.05). Clinical events were death, myocardial infarction, and target-lesion revascularization. Patients were followed up for a mean of 3 years. PR was observed in 50 (53%), and intermediate/negative remodeling, in 44 (47%). During the 3-year follow-up, there were 20 target-lesion revascularization events and 5 deaths (2 cardiac and 3 noncardiac), but no myocardial infarctions. Patients with PR showed significantly lower major adverse cardiac event (MACE; death, myocardial infarction, and target-lesion revascularization)-free survival (log-rank p = 0.03). However, patients with plaque rupture showed a nonsignificant trend toward lower MACE-free survival (p = 0.13), but there were no significant differences in MACE-free survival between those with single versus multiple plaque ruptures. Using multivariate logistic regression analysis, only culprit lesion PR was an independent predictor of MACEs (p = 0.04). In conclusion, culprit-lesion remodeling rather than the presence or absence of culprit-lesion plaque rupture was a strong predictor of long-term (3-year) clinical outcome in patients with acute coronary syndrome.
authors.affiliation: Division of Cardiology, Bell Land General Hospital, Sakai, Japan. hokura@fides.dti.ne.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Satoru
authors.initials: S
authors.lastname: Sumitsuji
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Terashima
authors.forename: Toru
authors.initials: T
authors.lastname: Kataoka
authors.forename: Motomaru
authors.initials: M
authors.lastname: Masutani
authors.forename: Mitsumasa
authors.initials: M
authors.lastname: Ohyanagi
authors.forename: Kenei
authors.initials: K
authors.lastname: Shimada
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Taguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yasuga
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Takeda
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Kojiro
authors.initials: K
authors.lastname: Awano
authors.forename: Kenichi
authors.initials: K
authors.lastname: Fujii
authors.forename: Gary S
authors.initials: GS
authors.lastname: Mintz
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D018084:Ultrasonography, Interventional