title: High suicide risk after the development of cognitive and working memory deficits caused by cannabis, cocaine and ecstasy use.
abstract: We report the case of attempted suicide by a 30-year-old man who had significant cognitive deficits that developed after at least three years of polysubstance use with cannabis, methylenedioxymethamphetamine (MDMA, "ecstasy") and cocaine. The patient reported increasing difficulties in his professional and interpersonal life which may have been associated with his cognitive dysfunction caused by his poly-drug use. In this setting, the patient complained of increasing symptoms of depression, including feelings of hopelessness and helplessness, and multi somatic complaints (based on DSM-IV criteria). These depressive symptoms led to the development of active suicidal ideation and ultimately to a suicide attempt. We propose that the patient's cognitive deficits resulted directly from his polysubstance use and contributed to his depression, suicide attempt and current serious suicidal ideation.
authors.affiliation: Department of Psychiatry, Saint'Andrea Hospital, University of Rome "La Sapienza," Italy. maurizio.pompili@uniroma1.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Pompili
authors.forename: David
authors.initials: D
authors.lastname: Lester
authors.forename: Paolo
authors.initials: P
authors.lastname: Girardi
authors.forename: Roberto
authors.initials: R
authors.lastname: Tatarelli
mesh_terms: D000328:Adult; D019970:Cocaine-Related Disorders / Q000150:complications*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D002189:Marijuana Abuse / Q000150:complications*; D008569:Memory Disorders / Q000175:diagnosis / Q000209:etiology*; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000009:adverse effects*; D009483:Neuropsychological Tests; D012307:Risk Factors; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000150:complications*; D013405:Suicide / Q000706:statistics & numerical data*
chemical_list: D018817:N-Methyl-3,4-methylenedioxyamphetamine