title: [Renal morphofunctional changes in peritonitis].
abstract: Acute hepatic insufficiency (AHI) is a topical problem in intensive therapy of peritonitis complications. In 30-60% of the cases, AHI is a component of polyorgan failure syndrome (POFS) which markedly worsens prognosis due to enhanced mortality rate. Different authors estimate lethality from 20-50 to 80-100%. Pathogenesis of AHI complicating the clinical course of peritonitis of different nature is underlain by endotoxemia and morphofunctional disturbances of renal microcirculation. Systemic endotoxemia is not restricted to renal damage alone but affects all physiological systems which leads to POFS. It means that improvement of pathogenetic therapy of AHI-complicated peritonitis requires a deeper insight into processes that take place in the kidneys during endotoxicosis and after its resolution.
authors.forename: D N
authors.initials: DN
authors.lastname: Telepanov
authors.forename: V E
authors.initials: VE
authors.lastname: Miliukov
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D000818:Animals; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D010538:Peritonitis / Q000150:complications / Q000503:physiopathology*; D012079:Renal Circulation / Q000502:physiology*