title: Allocation of deceased donor kidneys in São Paulo, Brazil: effect of human leukocyte antigen compatibility on graft survival.
abstract: In Brazil, organ transplantation has been regulated by a federal law since 1997. This law was created to guarantee equal access to treatment on a national scale. Deceased donor organ procurement and sharing are centralized and controlled by the Health Department of each state of the nation, following a regional allocation policy. In São Paulo, time on the waiting list was the main criterion adopted to allocate deceased donor kidneys up to January 1, 2002. After that, HLA mismatches (MM) were the main criterion. The aim of this study was to investigate the impact of HLA compatibility on graft survival among 3312 consecutive kidney recipients. The 2-year kidney graft survival rates were compared among recipients transplanted based on the waiting time policy and based on HLA MM. Better results were observed in the HLA MM group (78.1% vs 64.9%; P < .0001). Regarding kidney allocation based on HLA MM, recipients transplanted with 0 HLA-A, -B, or -DR MM showed significantly better 5-year survival rates than those with 1-2 or 3-4 or 5-6 HLA-A, -B, or -DR MM (70.36% vs 64.71% vs 58.07% vs 55.64%; P < .050). We concluded that HLA compatibility is a feasible criterion to allocate deceased donor kidneys in Brazil.
authors.affiliation: São Paulo Organ Allocation System, Health Secretariat of São Paulo, São Paulo, Brazil. ctrans@saude.sp.gov.br
authors.forename: F
authors.initials: F
authors.lastname: Monteiro
authors.forename: S A
authors.initials: SA
authors.lastname: Coria
authors.forename: R
authors.initials: R
authors.lastname: Boni
authors.forename: L A
authors.initials: LA
authors.lastname: Pereira
mesh_terms: D001938:Brazil; D002102:Cadaver; D006085:Graft Survival / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D018579:Patient Selection; D040841:Resource Allocation / Q000379:methods*; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000379:methods*; D014850:Waiting Lists
chemical_list: D006680:HLA Antigens