title: Accuracy of EEG source imaging of epileptic spikes in patients with large brain lesions.
abstract: OBJECTIVE
  To test the accuracy of EEG source imaging in epilepsy patients with large cerebral lesions. It is hypothesized that lesions are most likely to change conductivity properties and to significantly impair the accuracy of electromagnetic source imaging (ESI) based on the EEG. This has, however, not been tested in patients' EEG.
  
  
  METHODS
  Fourteen patients with focal epilepsy and large cerebral lesions underwent high-resolution (128-256 channels) interictal EEG recordings. Thirteen patients were operated, leading to seizure freedom in 12. The spike sources were localized with a distributed linear inverse solution (LAURA) and compared to the post-operative MRI or the results of other invasive or non-invasive exams.
  
  
  RESULTS
  In 12 patients ESI indicated the maximum source of the epileptic activity to be located within the epileptogenic zone (85%). One of the remaining cases was not seizure free after surgery. According to the ESI result, however, the focus was incompletely removed.
  
  
  CONCLUSIONS
  High resolution ESI constrained to the individual anatomy identifies the epileptogenic focus in patients with volume relevant brain lesions with excellent accuracy, comparable to that of other non-invasive methods.
  
  
  CONCLUSIONS
  Our results are of particular clinical importance, as they show that ESI can be extended to patients with large inhomogeneous lesions.
authors.affiliation: Functional Brain Mapping Laboratory, University Hospital Geneva, 24, Rue Micheli-du-Crest, CH-1211 Geneva, Switzerland. verena.brodbeck@medecine.unige.ch
authors.forename: Verena
authors.initials: V
authors.lastname: Brodbeck
authors.forename: Agustina M
authors.initials: AM
authors.lastname: Lascano
authors.forename: Laurent
authors.initials: L
authors.lastname: Spinelli
authors.forename: Margitta
authors.initials: M
authors.lastname: Seeck
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Michel
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000473:pathology* / Q000601:surgery; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D012189:Retrospective Studies; D014851:Wakefulness