title: Localized delivery of growth factors for periodontal tissue regeneration: role, strategies, and perspectives.
abstract: Difficulties associated with achieving predictable periodontal regeneration, means that novel techniques need to be developed in order to regenerate the extensive soft and hard tissue destruction that results from periodontitis. Localized delivery of growth factors to the periodontium is an emerging and versatile therapeutic approach, with the potential to become a powerful tool in future regenerative periodontal therapy. Optimized delivery regimes and well-defined release kinetics appear to be logical prerequisites for safe and efficacious clinical application of growth factors and to avoid unwanted side effects and toxicity. While adequate concentrations of growth factor(s) need to be appropriately localized, delivery vehicles are also expected to possess properties such as protein protection, precision in controlled release, biocompatibility and biodegradability, self-regulated therapeutic activity, potential for multiple delivery, and good cell/tissue penetration. Here, current knowledge, recent advances, and future possibilities of growth factor delivery strategies are outlined for periodontal regeneration. First, the role of those growth factors that have been implicated in the periodontal healing/regeneration process, general requirements for their delivery, and the different material types available are described. A detailed discussion follows of current strategies for the selection of devices for localized growth factor delivery, with particular emphasis placed upon their advantages and disadvantages and future prospects for ongoing studies in reconstructing the tooth supporting apparatus.
authors.affiliation: Department of Periodontology and Oral Medicine, School of Stomatology, The Fourth Military Medical University, Shaanxi, People's Republic of China. cfmsunhh@fmmu.edu.cn
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Chen
authors.forename: Richard M
authors.initials: RM
authors.lastname: Shelton
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Iain L C
authors.initials: IL
authors.lastname: Chapple
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods* / Q000639:trends*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D008954:Models, Biological; D010510:Periodontal Diseases / Q000628:therapy*; D010519:Periodontium / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D036341:Intercellular Signaling Peptides and Proteins