title: Prions remodel gene expression in yeast.
abstract: Epigenetic mechanisms participate in the regulation of gene transcription in eukaryotes. Two studies in yeast have revealed an additional mechanism for controlling global gene transcription that is based on an inherited self-perpetuating change in the conformation of two different components of key transcriptional regulatory complexes.
authors.affiliation: Kent Fungal Group, Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, UK. m.f.tuite@kent.ac.uk
authors.forename: Mick F
authors.initials: MF
authors.lastname: Tuite
authors.forename: Brian S
authors.initials: BS
authors.lastname: Cox
mesh_terms: D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics; D044127:Epigenesis, Genetic; D015966:Gene Expression Regulation, Fungal; D006801:Humans; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D011328:Prions / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics*; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: C065455:CYC8 protein, S cerevisiae; D004268:DNA-Binding Proteins; D011328:Prions; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins