title: Pulse wave velocity for assessment of arterial stiffness among people with spinal cord injury: a pilot study.
abstract: OBJECTIVE
  The most significant complication and leading cause of death for people with spinal cord injury (SCI) is coronary artery disease (CAD). It has been confirmed that aortic pulse wave velocity (PWV) is an emerging CAD predictor among able-bodied individuals. No prior study has described PWV values among people with SCI. The objective of this study was to compare aortic (the common carotid to femoral artery) PWV, arm (the brachial to radial artery) PWV, and leg (the femoral to posterior tibial artery) PWV in people with SCI (SCI group) to able-bodied controls (non-SCI group).
  
  
  METHODS
  Participants included 12 men with SCI and 9 non-SCI controls matched for age, sex, height, and weight. Participants with a history of CAD or current metabolic syndrome were excluded. Aortic, arm, and leg PWV was measured using the echo Doppler method.
  
  
  RESULTS
  Aortic PWV (mean +/- SD) in the SCI group (1,274 +/- 369 cm/s) was significantly higher (P < 0.05) than in the non-SCI group (948 +/- 110 cm/s). There were no significant between-group differences in mean arm PWV (SCI: 1,152 +/- 193 cm/s, non-SCI: 1,237 +/- 193 cm/s) or mean leg PWV (SCI: 1,096 +/- 173 cm/s, non-SCI: 994 +/- 178 cm/s) values.
  
  
  CONCLUSIONS
  Aortic PWV was higher among the SCI group compared with the non-SCI group. The higher mean aortic PWV values among the SCI group compared with the non-SCI group indicated a higher risk of CAD among people with SCI in the absence of metabolic syndrome.
authors.affiliation: Lyndhurst Center, Toronto Rehabilitation Institute, 520 Sutherland Drive, Toronto, Ontario, Canada M4G 3V9. miyatani.masae@torontorehab.on.ca
authors.forename: Masae
authors.initials: M
authors.lastname: Miyatani
authors.forename: Kei
authors.initials: K
authors.lastname: Masani
authors.forename: Paul I
authors.initials: PI
authors.lastname: Oh
authors.forename: Motohiko
authors.initials: M
authors.lastname: Miyachi
authors.forename: Milos R
authors.initials: MR
authors.lastname: Popovic
authors.forename: B Cathy
authors.initials: BC
authors.lastname: Craven
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D001794:Blood Pressure; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000209:etiology*; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011237:Predictive Value of Tests; D011673:Pulsatile Flow / Q000502:physiology*; D018570:Risk Assessment; D013119:Spinal Cord Injuries / Q000150:complications*