Synthesis of actin-depolymerizing compounds.
The artificial actin-depolymerizing compounds 3-6, based on aplyronine A, an actin-depolymerizing antitumor marine macrolide, were synthesized, and their actin-depolymerizing activities and cytotoxicities were evaluated.
Kitamura
Kazuhiro
K
Department of Chemistry, Faculty of Science and Technology, Keio University, 3-14-1 Hiyoshi, Kohoku, Yokohama 223-8522, Japan.
Teruya
Toshiaki
T
Kuroda
Takeshi
T
Kigoshi
Hideo
H
Suenaga
Kiyotake
K
D000199:Actins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D002460:Cell Line; D006367:HeLa Cells; D006801:Humans; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D012694:Serine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity
D000199:Actins; D007783:Lactones; D018942:Macrolides; C104057:aplyronine A; D012694:Serine