Histological differences in full-thickness vs. lamellar corneal pig-to-rabbit xenotransplantation.
To evaluate the differences in graft survival and histopathological characteristics between full-thickness and lamellar orthotopic corneal xenotransplantation in a pig-to-rabbit model, we orthotopically transplanted a full-thickness or the anterior half of a pig's cornea onto the OD of 16 rabbits. As a result, the median survival were 16.83 and 29.07 days for the full-thickness and lamellar xenografts, respectively (P = 0.0005). Histologically, the full-thickness corneal xenografts had massive infiltration by eosinophils, whereas the lamellar xenografts showed predominantly mononuclear infiltrates (P < 0.05). Given these preliminary findings, lamellar corneal xenografts in rabbits survived longer than the full-thickness xenografts and each type of graft demonstrated different rejection mechanisms.
Oh
Joo Youn
JY
Seoul Artificial Eye Center, Seoul National University Hospital Clinical Research Institute, Seoul, Korea.
Kim
Mee Kum
MK
Ko
Jung Hwa
JH
Lee
Hyun Ju
HJ
Park
Chung-Gyu
CG
Kim
Sang Joon
SJ
Wee
Won Ryang
WR
Lee
Jin Hak
JH
D000818:Animals; D003315:Cornea / Q000166:cytology / Q000473:pathology; D016039:Corneal Transplantation / Q000379:methods / Q000662:veterinary*; D004804:Eosinophils; D006084:Graft Rejection; D007963:Leukocytes, Mononuclear; D011817:Rabbits; D013552:Swine; D014183:Transplantation, Heterologous / Q000662:veterinary*