title: Non-NSAID non-H. pylori ulcer disease.
abstract: Non-NSAID non-Helicobacter pylori ulcer disease, which was believed to account for a minority of bleeding gastroduodenal ulcers, has been increasingly recognized for the past decade. Current data suggest that both relative proportion and actual numbers of patients with non-NSAID non-H. pylori ulcers have increased, whereas the prevalence of H. pylori-positive ulcers has declined. There is evidence to support that non-NSAID non-H. pylori ulcers associate with a higher risk of recurrent ulcer bleeding and a higher overall mortality as compared to H. pylori-positive ulcer disease. Patients with non-NSAID non-H. pylori ulcers are often older, sicker and more frequently experience bleeding episodes while in hospital. The pathogenesis of non-NSAID non-H. pylori ulcer is largely unknown and the efficacy of acid suppressants in the management and prevention of the disease remains to be defined. Well-designed, large-scale studies are awaited to shed light on this emerging condition.
authors.affiliation: Institute of Digestive Disease, The Chinese University of Hong Kong, Department of Medicine and Therapeutics, Prince of Wales Hospital, Hong Kong.
authors.forename: Dorothy K L
authors.initials: DK
authors.lastname: Chow
authors.forename: Joseph J Y
authors.initials: JJ
authors.lastname: Sung
mesh_terms: D000367:Age Factors; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D016480:Helicobacter pylori / Q000472:pathogenicity; D006801:Humans; D010437:Peptic Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000401:mortality; D015995:Prevalence; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents