Use of autologous platelet gel in female pelvic organ prolapse surgery: a feasibility study.
OBJECTIVE
We sought to evaluate whether autologous platelet gel (APG) application during anterior colporrhaphy could increase collagen content of the pubocervical fascia and thereby create a more durable repair.


METHODS
Prospective cohort study (Canadian Task Force classification II-2).


METHODS
University hospital.


METHODS
Nine patients undergoing anterior colporrhaphy.


METHODS
We applied APG to the surgical site during anterior colporrhaphy in 9 patients. We collected biopsy specimens from the anterior vaginal wall at surgery and 3 months postoperatively. Collagen content was measured and compared. We evaluated objective and subjective failure rates at 20 months postoperatively.


RESULTS
No significant increase occurred in collagen content at 3 months. Subjective failure rate was 12.5%, objective failure rate was 66.7%, and 1 (12.5%) patient required reoperation 10 months postoperatively.


CONCLUSIONS
The application of APG during anterior colporrhaphy does not seem to increase collagen content or durability of the surgical repair.
Einarsson
Jon I
JI
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. jeinarsson@partners.org
Jonsdottir
Kristin
K
Mandle
Robert
R
D000328:Adult; D003094:Collagen / Q000378:metabolism; D052858:Cystocele / Q000601:surgery*; D005205:Fascia / Q000502:physiology; D000071938:Fasciotomy; D005240:Feasibility Studies; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D014182:Transplantation, Autologous; D013520:Urologic Surgical Procedures / Q000379:methods*
D003094:Collagen