Embryonal neural tumours and cell death.
Medulloblastoma and neuroblastoma are malignant embryonal childhood tumours of the central and peripheral nervous systems, respectively, which often show poor clinical prognosis due to resistance to current chemotherapy. Both these tumours have deficient apoptotic machineries adopted from their respective progenitor cells. This review focuses on the specific background for tumour development, and highlights biological pathways that present potential targets for novel therapeutic approaches.
Johnsen
John Inge
JI
Department of Woman and Child Health, Karolinska Institutet, Astrid Lindgren Children's Hospital, Childhood Cancer Research Unit, Karolinska University Hospital, Stockholm, Sweden.
Kogner
Per
P
Albihn
Ami
A
Henriksson
Marie Arsenian
MA
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D016923:Cell Death / Q000187:drug effects; D016543:Central Nervous System Neoplasms / Q000196:embryology / Q000378:metabolism / Q000628:therapy*; D002648:Child; D006801:Humans; D008527:Medulloblastoma / Q000378:metabolism / Q000628:therapy; D008954:Models, Biological; D009373:Neoplasms, Germ Cell and Embryonal / Q000378:metabolism / Q000628:therapy*; D009447:Neuroblastoma / Q000378:metabolism / Q000628:therapy