An unusual observation of tetragametic chimerism: forensic aspects.
A 41-year-old healthy Caucasian male showed an unidentifiable direct AB0 group and a B group by an indirect method revealing the presence of natural antibodies anti-A1 and anti-A2. Mixed fields with anti-B and anti-A+B antisera led to the conclusion that blood group B and 0 cell populations were present in a 1:1 ratio. A negative anamnesis for both transplantation and transfusion suggested a chimerism. DNA analysis of tissues revealed a tetragametic chimerism due to an apparent double parental contribution of nuclei in a phenotypically normal man.
Verdiani
S
S
Department of Legal Medicine, University of Genova, Via De Toni 12, 16132, Genova, Italy.
Bonsignore
A
A
Casarino
L
L
Ferrari
G M
GM
Zia
S C
SC
De Stefano
F
F
D000017:ABO Blood-Group System / Q000235:genetics*; D000328:Adult; D001788:Blood Grouping and Crossmatching; D046528:Chimerism; D016172:DNA Fingerprinting; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020080:Tandem Repeat Sequences
D000017:ABO Blood-Group System