Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity.
Peroxisome proliferator-activated receptor alpha and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR alpha-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E(2)-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E(2)-treated group, but interestingly not in PPAR alpha-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E(2)-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR alpha and E2, causing obesity in vivo.
Kim
Bang Hyun
BH
Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea.
Won
Young Suk
YS
Kim
Dae Yong
DY
Kim
Bora
B
Kim
Eun-Young
EY
Yoon
Mijung
M
Oh
Goo Taeg
GT
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism*; D000818:Animals; D004041:Dietary Fats; D004967:Estrogens / Q000378:metabolism; D005260:Female; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009765:Obesity / Q000378:metabolism*; D010052:Ovariectomy; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D004041:Dietary Fats; D004967:Estrogens; D047493:PPAR alpha; D008071:Lipoprotein Lipase