title: Safety of living donor in pediatric liver transplantation--analysis of 100 consecutive donors.
abstract: OBJECTIVE
  The aim of this study was to evaluate safety of donors of liver fragments of different size and regeneration of the remaining liver.
  
  
  METHODS
  Between October 1999 and January 2007 liver segments II and III were harvested from 90 donors and segments II, III and IV from 10 donors. Liver volumetry by computed tomography (CT) and biochemical liver function tests were performed at baseline and 7 days, 30 days and 12 months after the operation.
  
  
  RESULTS
  CT-assisted volumetry correlated with mass of harvested graft (r=0.779; p<0.05). Twelve months after resection mean regeneration index was 138.64% +/- 23.98% in donors of segments II, III and IV and 109.93% +/- 18.36% in donors of segments II and III (p<0.02). Transient elevation of bilirubin and trans-aminases and decreased prothrombin index were observed in the early postoperative period. Twelve months after the operation mean levels of these parameters were within normal limits. No deaths and no severe complications were observed during the follow-up.
  
  
  CONCLUSIONS
  CT-assisted volumetry permits an adequate estimation of liver fragments intended for harvesting. Harvesting of II and III or II, III and IV segments does not compromise donor's safety. Liver regeneration is significantly greater after harvesting of II, III and IV segments than that of II and III segments.
authors.affiliation: Department of General, Transplant and Liver Surgery, Medical University of Warsaw, Poland. jrpalusz@excite.com
authors.forename: Rafał
authors.initials: R
authors.lastname: Paluszkiewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zieniewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Kalinowski
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Grzelak
authors.forename: Piotr
authors.initials: P
authors.lastname: Hevelke
authors.forename: Ryszard
authors.initials: R
authors.lastname: Pacho
authors.forename: Robert
authors.initials: R
authors.lastname: Lechowicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Kaliciński
authors.forename: Marek
authors.initials: M
authors.lastname: Krawczyk
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D008099:Liver / Q000033:anatomy & histology; D016031:Liver Transplantation / Q000379:methods; D019520:Living Donors; D008297:Male; D009929:Organ Size; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin