title: [Experimental studies on hypoglycemic effects of total flavonoid from Toona sinensis].
abstract: OBJECTIVE
  To study hypoglycemic effects of total flavonoid from Toona sinensis (TSTF) on diabetic mice model.
  
  
  METHODS
  To confect alloxan 0.02 g/ml with NS and injected alloxan into abdominal cavity to induce diabetic model, and all rats were fed bid with glucose for 2 consecutive days, then the blood glucose was detected by glucose oxidizes, when hypoglycemic point >11.00 mmol/L the rats were successful model made. 100 model rats were divided into 5 groups as contrast groups (distilled water), model control control groups, hight doses group (0.12 g/kg) and low doses group (0.6 g/kg) of TSTF, positive control groups of phenformin (0.10 g/kg); In addition to set 20 natural rats (distilled water), and all groups were fed qd for 15 consecutive days, and then the blood glucose were detected by glucose oxidizes in the sixteenth day.
  
  
  RESULTS
  The blood glucose levels of the diabetic rats in TSTF groups significantly decreased.
  
  
  CONCLUSIONS
  TSTF can significantly decrease the blood glucose levels of diabetic mice induced by alloxan.
authors.affiliation: Depart. of Pharmacy, Guangdong Provincial People's Hospital, Guangzhou 510080, China. johnsonzhang2006@163.com
authors.forename: Jun-Fang
authors.initials: JF
authors.lastname: Zhang
authors.forename: Jia-Yu
authors.initials: JY
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Wen
authors.forename: Ding-Yong
authors.initials: DY
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Yang
authors.forename: Qiu-Qiong
authors.initials: QQ
authors.lastname: Liu
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D031587:Cedrela / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006943:Hyperglycemia / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008517:Phytotherapy; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation; D051381:Rats
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D007004:Hypoglycemic Agents