title: Numerical simulation of bone regeneration in a bone chamber.
abstract: While mathematical models are able to capture essential aspects of biological processes like fracture healing and distraction osteogenesis, their predictive capacity in peri-implant osteogenesis remains uninvestigated. We tested the hypothesis that a mechano-regulatory model has the potential to predict bone regeneration around implants. In an in vivo bone chamber set-up allowing for controlled implant loading (up to 90 microm axial displacement), bone tissue formation was simulated and compared qualitatively and quantitatively with histology. Furthermore, the model was applied to simulate excessive loading conditions. Corresponding to literature data, implant displacement magnitudes larger than 90 microm predicted the formation of fibrous tissue encapsulation of the implant. In contradiction to findings in orthopedic implant osseointegration, implant displacement frequencies higher than 1 Hz did not favor the formation of peri-implant bone in the chamber. Additional bone chamber experiments are needed to test these numerical predictions.
authors.affiliation: Division of Biomechanics and Engineering Design, Department of Mechanical Engineering, K.U. Leuven, Celestijnenlaan 300C-PB 2419, 3001 Leuven, Belgium. Liesbet.geris@mech.kuleuven.be
authors.forename: L
authors.initials: L
authors.lastname: Geris
authors.forename: K
authors.initials: K
authors.lastname: Vandamme
authors.forename: I
authors.initials: I
authors.lastname: Naert
authors.forename: J
authors.initials: J
authors.lastname: Vander Sloten
authors.forename: J
authors.initials: J
authors.lastname: Duyck
authors.forename: H
authors.initials: H
authors.lastname: Van Oosterwyck
mesh_terms: D000818:Animals; D003198:Computer Simulation; D015921:Dental Implants; D019232:Dental Restoration Failure; D003799:Dental Stress Analysis; D020342:Finite Element Analysis; D020007:Implants, Experimental; D008954:Models, Biological; D009716:Numerical Analysis, Computer-Assisted; D016348:Osseointegration / Q000502:physiology*; D011817:Rabbits; D013977:Tibia / Q000601:surgery
chemical_list: D015921:Dental Implants