title: Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors.
abstract: Primary testicular tumors are the most common causes of cancer in male dogs. Overall, the majority of canine patients should be cured by testicular surgery. However, tumor markers are not well-known in veterinary medicine. We sought to determine using immunohistochemistry whether the combined human testicular tumor markers (placental alkaline phosphatase, OCT3/4, CD30, alpha-fetoprotein, inhibin-alpha, vimentin, c-KIT, and desmin) are expressed in canine seminomas and Sertoli cell tumors (SCTs). We examined 35 canine testicular tumors, 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas. Both inhibin-alpha and vimentin were expressed significantly in canine SCTs. The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans. All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression.
authors.affiliation: Department of Veterinary Pathobiology, Small Animal Tumor Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 143-701, Korea.
authors.forename: Chi-Ho
authors.initials: CH
authors.lastname: Yu
authors.forename: Du-Na
authors.initials: DN
authors.lastname: Hwang
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Yhee
authors.forename: Jong-Hyuk
authors.initials: JH
authors.lastname: Kim
authors.forename: Keum-Soon
authors.initials: KS
authors.lastname: Im
authors.forename: Whan-Gook
authors.initials: WG
authors.lastname: Nho
authors.forename: Young-Soo
authors.initials: YS
authors.lastname: Lyoo
authors.forename: Jung-Hyang
authors.initials: JH
authors.lastname: Sur
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry / Q000662:veterinary*; D008297:Male; D018239:Seminoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D012707:Sertoli Cell Tumor / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor