title: Oxidative stress in depressive patients with gastric adenocarcinoma.
abstract: Recent data from several studies suggest that oxidative stress is involved in the biochemical mechanisms that underlie neuropsychiatric disorders. The present study was designed to investigate oxidative stress status in depressive patients with gastric adenocarcinoma (GA) at TNM stage III. Oxidative stress, depression and expression of specific genes were monitored during a pretreatment period. Serum total antioxidant capacity, catalase, superoxide dismutase concentrations, and antisuperoxide anion capacity (A-ASC) were significantly decreased in depressive patients compared to control subjects, whereas serum malondialdehyde (MDA) levels were significantly increased. Importantly, the formation of 8-hydroxy-deoxyguanosine (8-OHdG) accumulated. Furthermore, SYBR Green real-time PCR revealed that the expression levels of human oxoguanine glycosylase 1 and APEX nuclease 1 (APEX1) were increased in depressive patients. Pearson correlation analysis revealed that depression was positively correlated with SAS, SCL-90, MDA, 8-OHdG and APEX1, but negatively correlated with A-ASC. Thus, this study confirms oxidative imbalance in depressive patients with GA, and oxidative stress may play a role in the onset and exacerbation of depression.
authors.affiliation: Department of Clinical Oncology, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China. weiyongchang8@163.com
authors.forename: Yong-Chang
authors.initials: YC
authors.lastname: Wei
authors.forename: Fu-Ling
authors.initials: FL
authors.lastname: Zhou
authors.forename: Da-Lin
authors.initials: DL
authors.lastname: He
authors.forename: Ji-Rong
authors.initials: JR
authors.lastname: Bai
authors.forename: Hui
authors.initials: H
authors.lastname: Ding
authors.forename: Xin-Yang
authors.initials: XY
authors.lastname: Wang
authors.forename: Ke-Jun
authors.initials: KJ
authors.lastname: Nan
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood; D045647:DNA Glycosylases / Q000235:genetics / Q000378:metabolism; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase / Q000235:genetics / Q000378:metabolism; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000378:metabolism; D003863:Depression / Q000150:complications*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D013274:Stomach Neoplasms / Q000150:complications*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D002374:Catalase; D013482:Superoxide Dismutase; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human; C085108:APEX1 protein, human; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D003849:Deoxyguanosine