Quantification of dengue virus type 3 RNA in fatal and non-fatal cases in Brazil, 2002.
We examined levels of dengue virus type 3 (DENV-3) RNA in association with the type of infection (primary or secondary) in 42 patients with fatal and non-fatal outcomes in Rio de Janeiro, Brazil, 2002. Subjects with fatal outcomes had mean virus titers significantly higher than those who survived (12.5 vs. 7.9 log(10) RNA copies/ml). Because primary infections were confirmed among the fatal cases (52.1%), antibody-dependent enhancement alone did not explain all the cases of severe disease in this study population. These findings suggest that high levels of DENV-3 may have contributed to the severe form of dengue in Rio de Janeiro, 2002.
de Araújo
Josélio M G
JM
Laboratory of Flavivirus, Oswaldo Cruz Institute, 21045-900 Rio de Janeiro, Brazil. joselio@ioc.fiocruz.br
de Filippis
Ana M B
AM
Schatzmayr
Hermann G
HG
de Araújo
Eliane S M
ES
Britto
Constança
C
Cardoso
Maria A
MA
Camacho
Luiz A B
LA
Nogueira
Rita M R
RM
D019067:Antibody-Dependent Enhancement / Q000276:immunology; D001938:Brazil / Q000453:epidemiology; D003715:Dengue / Q000453:epidemiology / Q000401:mortality / Q000821:virology*; D003716:Dengue Virus / Q000145:classification / Q000235:genetics* / Q000276:immunology; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction
D007074:Immunoglobulin G; D012367:RNA, Viral