title: Preservation of basophils in dapsone-induced agranulocytosis suggests a possible pathogenetic role for leucocyte peroxidases.
abstract: We describe a hitherto unreported laboratory observation, namely the selective preservation of basophils, in a case of severe dapsone-induced agranulocytosis. Dapsone is known to be metabolised by peroxidases to nitroso derivatives in non-hemopoietic cells where these can in turn act as haptens. Our observation that basophils are selectively spared in this syndrome supports the hypothesis that leucocyte peroxidases function in a similar way to facilitate the pathogenesis of this form of agranulocytosis in susceptible individuals.
authors.affiliation: Department of Haematology, West Suffolk Hospital, Cambridge University Hospitals NHS Trust, Cambridge, UK.
authors.forename: M
authors.initials: M
authors.lastname: Besser
authors.forename: J
authors.initials: J
authors.lastname: Vera
authors.forename: J
authors.initials: J
authors.lastname: Clark
authors.forename: D
authors.initials: D
authors.lastname: Chitnavis
authors.forename: C
authors.initials: C
authors.lastname: Beatty
authors.forename: G
authors.initials: G
authors.lastname: Vassiliou
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced* / Q000201:enzymology*; D001491:Basophils / Q000201:enzymology; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008179:Lupus Erythematosus, Discoid / Q000188:drug therapy*; D010544:Peroxidases / Q000378:metabolism*; D014021:Tissue Preservation
chemical_list: D003622:Dapsone; D010544:Peroxidases