title: Correlations of water quality parameters with mutagenicity of chlorinated drinking water samples.
abstract: Adverse health effects that may result from chronic exposure to mixtures of disinfection by-products (DBPs) present in drinking waters may be linked to both the types and concentrations of DBPs present. Depending on the characteristics of the source water and treatment processes used, both types and concentrations of DBPs found in drinking waters vary substantially. The composition of a drinking-water mixture also may change during distribution. This study evaluated the relationships between mutagenicity, using the Ames assay, and water quality parameters. The study included information on treatment, mutagenicity data, and water quality data for source waters, finished waters, and distribution samples collected from five full-scale drinking water treatment plants, which used chlorine exclusively for disinfection. Four of the plants used surface water sources and the fifth plant used groundwater. Correlations between mutagenicity and water quality parameters are presented. The highest correlation was observed between mutagenicity and the total organic halide concentrations in the treated samples.
authors.affiliation: U.S. Environmental Protection Agency, Cincinnati, Ohio 45268, USA. schenck.kathleen@epa.gov
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Schenck
authors.forename: Mano
authors.initials: M
authors.lastname: Sivaganesan
authors.forename: Glenn E
authors.initials: GE
authors.lastname: Rice
mesh_terms: D000818:Animals; D002713:Chlorine / Q000032:analysis / Q000633:toxicity*; D004202:Disinfectants / Q000032:analysis / Q000633:toxicity*; D004203:Disinfection; D005374:Filtration; D054879:Halogenation; D066298:In Vitro Techniques; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009930:Organic Chemicals / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D014881:Water Supply / Q000032:analysis / Q000592:standards*
chemical_list: D004202:Disinfectants; D009153:Mutagens; D009930:Organic Chemicals; D002713:Chlorine