Evolution models with base substitutions, insertions, deletions, and selection.
The evolution model with parallel mutation-selection scheme is solved for the case when selection is accompanied by base substitutions, insertions, and deletions. The fitness is assumed to be either a single-peak function (i.e., having one finite discontinuity) or a smooth function of the Hamming distance from the reference sequence. The mean fitness is calculated exactly in large-genome limit. In the case of insertions and deletions the evolution characteristics depend on the choice of reference sequence.
Saakian
D B
DB
Institute of Physics, Academia Sinica, Nankang, Taipei 11529, Taiwan. saakian@yerphi.am
D001483:Base Sequence; D055592:Biophysical Phenomena; D019143:Evolution, Molecular; D008957:Models, Genetic; D016254:Mutagenesis, Insertional; D009154:Mutation; D012641:Selection, Genetic; D017384:Sequence Deletion