title: Cytotoxic prenylated flavonoids from the stem bark of Maackia amurensis.
abstract: Five new prenylated flavonoids, maackiaflavanone A (1), maackiaflavanone B (2), maackiapentone (3), maackiapterocarpan A (4), maackiapterocarpan B (5) along with eleven known flavonoids were isolated from the stem bark of Maackia amurensis. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4, 6, 8-12 and 14-16 against four human cancer cell lines, A375S2, HeLa, MCF-7 and HepG2, were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, compound 2 showed the strongest cytotoxic activity with IC(50) value of 7.8 microM against A375S2 and euchrenone b(1) showed the most potent cytotoxicity with IC(50) value of 4.5 microM against HeLa.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Xiong
authors.initials: X
authors.lastname: Li
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Xia
authors.forename: Zhi-Hui
authors.initials: ZH
authors.lastname: Wang
authors.forename: Wei-Ning
authors.initials: WN
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Cui
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D029901:Maackia / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D054876:Prenylation
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids