title: [Pharmacogenetics and tailored drug therapy].
abstract: Pharmacogenetics traditionally designates the study of genetically determined variation in metabolism of drugs and toxins from the environment. The concept of phamacogenetics has been widened to encompass how essential genetic alterations central to the development of diseases may by used to target medical treatment in a patient-tailored way. This paper highlights some of the novel developments in relation to oncology and haematology.
authors.affiliation: Haematologisk Afdeling, Rigshospitalet, DK-2100 København Ø. borregaard@rh.regionh.dk
authors.forename: Finn Cilius
authors.initials: FC
authors.lastname: Nielsen
authors.forename: Niels
authors.initials: N
authors.lastname: Borregaard
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics; D010597:Pharmacogenetics; D010879:Piperazines / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000627:therapeutic use*; D011743:Pyrimidines / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate