title: Modeling of soft poroelastic tissue in time-harmonic MR elastography.
abstract: Elastography is an emerging imaging technique that focuses on assessing the resistance to deformation of soft biological tissues in vivo. Magnetic resonance elastography (MRE) uses measured displacement fields resulting from low-amplitude, low-frequency (10 Hz-1 kHz) time-harmonic vibration to recover images of the elastic property distribution of tissues including breast, liver, muscle, prostate, and brain. While many soft tissues display complex time-dependent behavior not described by linear elasticity, the models most commonly employed in MRE parameter reconstructions are based on elastic assumptions. Further, elasticity models fail to include the interstitial fluid phase present in vivo. Alternative continuum models, such as consolidation theory, are able to represent tissue and other materials comprising two distinct phases, generally consisting of a porous elastic solid and penetrating fluid. MRE reconstructions of simulated elastic and poroelastic phantoms were performed to investigate the limitations of current-elasticity-based methods in producing accurate elastic parameter estimates in poroelastic media. The results indicate that linearly elastic reconstructions of fluid-saturated porous media at amplitudes and frequencies relevant to steady-state MRE can yield misleading effective property distributions resulting from the complex interaction between their solid and fluid phases.
authors.affiliation: Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA. phillip.r.perrinez@dartmouth.edu
authors.forename: Phillip R
authors.initials: PR
authors.lastname: Perriñez
authors.forename: Francis E
authors.initials: FE
authors.lastname: Kennedy
authors.forename: Elijah E W
authors.initials: EE
authors.lastname: Van Houten
authors.forename: John B
authors.initials: JB
authors.lastname: Weaver
authors.forename: Keith D
authors.initials: KD
authors.lastname: Paulsen
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D055119:Elastic Modulus; D054459:Elasticity Imaging Techniques; D020342:Finite Element Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008954:Models, Biological; D019047:Phantoms, Imaging; D016062:Porosity; D045730:Soy Foods