Altered frontal-parietal functioning during verbal working memory in children and adolescents with heavy prenatal alcohol exposure.
This study evaluated the neural basis of verbal working memory (WM) function in a group of 20 children and adolescents with fetal alcohol spectrum disorders (FASDs) and 20 typically developing comparison participants using functional magnetic resonance imaging (fMRI). Both groups showed prominent activation in the frontal-parietal-cerebellar network known to be important for verbal WM. Despite equivalent behavioral performance between groups, alcohol-exposed individuals showed increased activation relative to typically developing individuals in left dorsal frontal and left inferior parietal cortices, and bilateral posterior temporal regions during verbal WM. These effects remained even when group differences on IQ were statistically controlled. This pattern of increased activation coupled with equivalent behavioral performance between groups suggests that individuals with FASD recruit a more extensive network of brain regions during verbal WM relative to typically developing individuals. These findings may suggest that frontal-parietal processing during verbal WM is less efficient in alcohol-exposed individuals.
O'Hare
Elizabeth D
ED
Department of Neurology, University of California, Los Angeles, CA, USA. edohare@berkeley.edu
Lu
Lisa H
LH
Houston
Suzanne M
SM
Bookheimer
Susan Y
SY
Mattson
Sarah N
SN
O'Connor
Mary J
MJ
Sowell
Elizabeth R
ER
D000293:Adolescent; D000428:Alcohol Drinking / Q000009:adverse effects*; D000704:Analysis of Variance; D001931:Brain Mapping; D002648:Child; D017352:Echo-Planar Imaging / Q000379:methods; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects* / Q000502:physiology; D009483:Neuropsychological Tests; D010100:Oxygen / Q000097:blood; D010296:Parietal Lobe / Q000098:blood supply / Q000187:drug effects* / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D014706:Verbal Learning / Q000187:drug effects* / Q000502:physiology
D010100:Oxygen