Medicinal Flowers. XXVI. structures of acylated oleanane-type triterpene oligoglycosides, yuchasaponins A, B, C, and D, from the flower buds of Camellia oleifera-gastroprotective, aldose reductase inhibitory, and radical scavenging effects-.
The methanolic extract and its 1-butanol-soluble fraction from the flower buds of Camellia oleifera ABEL were found to exhibit inhibitory effects on ethanol- and indomethacin-induced gastric mucosal lesions in rats. The ethyl acetate- and 1-butanol-soluble fractions also showed inhibitory effects on rat lens aldose reductase and scavenging effects on 1,1-diphenylpicryl-2-hydrazyl radical and superoxide. From the 1-butanol-soluble fraction, four new acylated oleanane-type triterpene oligoglycosides, yuchasaponins A, B, C, and D, were isolated and their structures were elucidated on the basis of chemical and physicochemical evidence. On the other hand, quercetin 3-O-alpha-L-rhamnopyranoside and kaempferol 3-O-alpha-L-rhamnopyranoside were isolated from the ethyl acetate- and 1-butanol-soluble fractions as the principal constituents, and their gastroprotective effects were examined.
Sugimoto
Sachiko
S
Kyoto Pharmaceutical University, Yamashitaa-ku, Kyoto 607-8412, Japan.
Chi
Guihua
G
Kato
Yasuyo
Y
Nakamura
Seikou
S
Matsuda
Hisashi
H
Yoshikawa
Masayuki
M
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D028244:Camellia / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D023421:Models, Animal; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
D000897:Anti-Ulcer Agents; D016166:Free Radical Scavengers; D012503:Saponins; D014315:Triterpenes; C413246:oleanane; D009828:Oleanolic Acid; D000449:Aldehyde Reductase