Caffeinated and alcoholic beverage intake in relation to ovulatory disorder infertility.
BACKGROUND
Many studies have examined whether caffeine, alcohol, or specific beverages containing these substances affect fertility in women. However, most of these studies have retrospectively collected information on alcohol and caffeine intake, making the results susceptible to biases.


METHODS
We followed 18,555 married women without a history of infertility for 8 years as they attempted to become (or became) pregnant. Diet was measured twice during this period and prospectively related to the incidence of ovulatory disorder infertility.


RESULTS
There were 438 incident report of ovulatory disorder infertility during follow-up. Intakes of alcohol and caffeine were unrelated to the risk of ovulatory disorder infertility. Comparing the highest to lowest categories of intake, the multivariate-adjusted relative risk, was 1.11 (95% confidence interval = 0.76-1.64; P for trend 0.78) for alcohol and 0.86 (0.61-1.20; 0.44) for total caffeine. However, intake of caffeinated soft drinks was positively related to ovulatory disorder infertility. Comparing the highest to lowest categories of caffeinated soft drink consumption, the RR was 1.47 (1.09-1.98; 0.01). Similar associations were observed for noncaffeinated, sugared, diet, and total soft drinks.


CONCLUSIONS
Our findings do not support the hypothesis that alcohol and caffeine impair ovulation to the point of decreasing fertility. The association between soft drinks and ovulatory disorder infertility seems not to be attributable to their caffeine or sugar content, and deserves further investigation.
Chavarro
Jorge E
JE
Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. jchavarr@hsph.harvard.edu
Rich-Edwards
Janet W
JW
Rosner
Bernard A
BA
Willett
Walter C
WC
D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D000858:Anovulation / Q000453:epidemiology*; D001628:Beverages; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects*; D002253:Carbonated Beverages; D016001:Confidence Intervals; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000453:epidemiology*; D009726:Nurses; D010060:Ovulation / Q000187:drug effects*; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D055815:Young Adult
D002110:Caffeine