title: Selective electrochemical sensing of calcium dobesilate based on the nano-Pd/CNTs modified pyrolytic graphite electrode.
abstract: A new palladium nanoparticle functionalized multi-wall carbon nanotubes (nano-Pd/CNTs) modified pyrolytic graphite electrode (PGE) has been fabricated for electrochemical sensing of calcium dobesilate (CD) in pharmaceutical capsules. The nano-Pd/CNTs were characterized by transmission electron microscopy (TEM) and X-ray diffraction (XRD). The nano-Pd/CNTs composite showed a strong electrocatalytic property for CD. The anodic peak current is 6-fold than that obtained in bare PGE and the oxidation potential has an obvious shift to negative. The anodic peak current is proportional to the concentration of CD in the range of 1.0 x 10(-7) to 7.0 x 10(-4)mol L(-1), with a linear relative coefficient r=0.999 and a detection limit 4.0 x 10(-8)mol L(-1) (S/N=3). This kind of electrode shows good stability, sensitivity, reproducibility, large linear range and low detection limit towards electrochemical determination of CD. The proposed method provides a selective and sensitive electrochemical sensor of calcium dobesilate.
authors.affiliation: Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PR China.
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Hu
authors.forename: Long
authors.initials: L
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Guo
authors.forename: Shijun
authors.initials: S
authors.lastname: Shao
authors.forename: Xiaolai
authors.initials: X
authors.lastname: Wang
mesh_terms: D002123:Calcium Dobesilate / Q000032:analysis*; D002214:Capsules / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation / Q000379:methods; D004566:Electrodes; D006108:Graphite; D053758:Nanoparticles; D037742:Nanotubes, Carbon; D010165:Palladium; D004364:Pharmaceutical Preparations
chemical_list: D002214:Capsules; D037742:Nanotubes, Carbon; D004364:Pharmaceutical Preparations; D002123:Calcium Dobesilate; D010165:Palladium; D006108:Graphite