Stroop-test interference in bipolar disorder.
We analysed Stroop (neuropsychological screening test) measures of response inhibition in 18 twin pairs discordant for bipolar I disorder compared with 17 healthy control pairs, as well as 40 singletons with bipolar disorder with psychotic features and a family history of psychosis, 46 of their first-degree relatives without bipolar disorder or psychosis and 48 controls. In both studies, individuals with bipolar disorder showed Stroop deficits and their first-degree relatives showed intact performance. In the twin patients, an interference score was associated with depressive symptoms. Having a first-degree relative with bipolar disorder, even a familial, psychotic form, did not confer risk for enhanced susceptibility to interference in our studies.
Kravariti
Eugenia
E
Institute of Psychiatry, King's College London, De Crespigny Park, London SE5 8AF, UK. e.kravariti@iop.kcl.ac.uk
Schulze
Katja
K
Kane
Fergus
F
Kalidindi
Sridevi
S
Bramon
Elvira
E
Walshe
Muriel
M
Marshall
Nicolette
N
Hall
Mei-Hua
MH
Georgiades
Anna
A
McDonald
Colm
C
Murray
Robin M
RM
D001714:Bipolar Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D020022:Genetic Predisposition to Disease / Q000235:genetics* / Q000523:psychology; D006801:Humans; D009483:Neuropsychological Tests; D010375:Pedigree; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology