SUMO conjugation and cardiovascular development.
SUMOs (Small Ubiquitin-like modifiers) belong to a superfamily of ubiquitin like proteins (Ubls) that are covalently conjugated to their substrates via enzymatic cascade reactions. The heterodimeric activating complex (SAE1/SAE2, E1) and conjugating enzyme (Ubc9, E2) required for the SUMO conjugation pathway are distinct from those involved in other Ubl pathways, and the presence of ligases (E3) stimulates the conjugation reaction. SUMO is implicated in a variety of physiological as well as pathological processes such as cell division, signal transduction, DNA damage and repair, and cancer development. This review focuses on the fundamental features of SUMO conjugation and its potential implication in cardiovascular development.
Wang
Jun
J
Institute of Biosciences and Technology, Texas AandM Health Science Center, 2121 W. Holcombe, Boulevard, Houston, TX 77030, USA. junwang@ibt.tamhsc.edu
D000595:Amino Acid Sequence; D002319:Cardiovascular System / Q000254:growth & development*; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction; D025841:Small Ubiquitin-Related Modifier Proteins / Q000737:chemistry / Q000378:metabolism*
D025841:Small Ubiquitin-Related Modifier Proteins