Polyfluoroalkyl chemicals in house dust.
We developed a high throughput analytical method using on-line solid phase extraction coupled with isotope dilution high-performance liquid chromatography-tandem mass spectrometry (on-line SPE-HPLC-MS/MS) to simultaneously determine the concentrations of 17 polyfluoroalkyl chemicals (PFCs) in house dust. The sample preparation includes dispersion of the dust samples in 0.1 M formic acid:MeOH (1:1), followed by agitation and filtration, addition of the isotope-labeled internal standard solution to the filtrate, and analysis by on-line SPE-HPLC-MS/MS. The limits of quantitation were <4.0 ng/g. The method accuracies ranged between 73.2% and 100.2% for the different analytes at two spike levels. We confirmed the validity of the method by analyzing 39 household dust samples collected in 2004. Of the 17 PFCs measured, 6 of them--perfluorobutane sulfonate (PFBuS), N-ethyl-perfluorooctane sulfonamide, 2-(N-ethyl-perfluorooctane sulfonamido) acetic acid (Et-PFOSA-AcOH), 2-(N-methyl-perfluorooctane sulfonamido) ethanol (Me-PFOSA-EtOH), perfluorohexane sulfonate (PFHxS), and perfluorooctane sulfonate (PFOS)--had detection frequencies >70%. We detected PFOS, PFBuS, and PFHxS at the highest median concentration, followed by Et-PFOSA-AcOH and Me-PFOSA-EtOH.
Kato
Kayoko
K
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, 4770 Buford Hwy., Mailstop F53, Atlanta, GA 30341, USA.
Calafat
Antonia M
AM
Needham
Larry L
LL
D002851:Chromatography, High Pressure Liquid; D004391:Dust / Q000032:analysis*; D005466:Fluorocarbons / Q000032:analysis*; D015203:Reproducibility of Results; D053719:Tandem Mass Spectrometry
D004391:Dust; D005466:Fluorocarbons