title: Diagnosis, management and outcome of clinically- suspected spinal infection.
abstract: OBJECTIVE
  Spontaneous spinal infection (SI) is a quite rare but serious entity. This study aimed to evaluate outcome and follow-up data of SI cases without a microbiological diagnosis (suspected SI).
  
  
  METHODS
  We undertook a retrospective, comparative study of 82 spontaneous SI cases in adults presenting over an 11-year period to two Italian hospitals.
  
  
  RESULTS
  The diagnostic yields of blood culture, percutaneous needle biopsy of spine, and surgical sample culture were 43.6%, 72.7%, and 91.6%, respectively. Overall, causative organisms were identified in 60 (73.2%) cases, the most frequently isolated pathogens being Staphylococcus aureus and Mycobacterium tuberculosis. The median diagnostic delay was similar (p=0.39) in pyogenic (1 month) and suspected (0.5 month) SI cases, and longer in tuberculous cases (4 months) than in the other SI case groups (p=0.069 and p=0.062, respectively). All patients received antibiotic treatment, and 21 (25.5%) underwent surgery, that was required more frequently in tuberculous (40.7%) than in pyogenic (25.0%) and suspected SI cases (9.1%) (p=0.028). Of 67 patients who completed a 1-year follow-up period, 24 had persisting painful disability that was more frequent in tuberculous (66.7%) cases than in pyogenic (21.7%) and suspected SI (15.0%) cases (p=0.03).
  
  
  CONCLUSIONS
  Although a microbiological diagnosis was not achieved in nearly a quarter of SI cases, both diagnostic delay and outcome were similar to those of pyogenic SI cases. Earlier recognition of tuberculous SI is mandatory, as this is associated with the highest long-term morbidity.
authors.affiliation: Unit of Infectious Diseases, University Hospital, Trieste, Italy. roberto.luzzati@aots.sanita.fvg.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Luzzati
authors.forename: Donatella
authors.initials: D
authors.lastname: Giacomazzi
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Danzi
authors.forename: Leonello
authors.initials: L
authors.lastname: Tacconi
authors.forename: Ercole
authors.initials: E
authors.lastname: Concia
authors.forename: Sandro
authors.initials: S
authors.lastname: Vento
mesh_terms: D000328:Adult; D001707:Biopsy, Needle; D001769:Blood / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D012189:Retrospective Studies; D013122:Spinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D013211:Staphylococcus aureus / Q000302:isolation & purification; D018709:Statistics, Nonparametric; D014399:Tuberculosis, Spinal / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery