title: Four successful pregnancies in a patient with mucopolysaccharidosis type I treated by allogeneic bone marrow transplantation.
abstract: To date, little is known about the fertility of women suffering from mucopolysaccharidosis type I (MPS I). We report on a female patient with MPS I treated by allogeneic bone marrow transplantation (BMT) at the age of 4 years (after a conditioning regimen containing busulfan 16 mg/kg and cyclophosphamide 100 mg/kg) who had four successful pregnancies without any reproductive assistance. Clinical and biological examinations of the children were normal. On the basis of this case, we discuss the fertility counselling of female MPS I patients at the time of BMT.
authors.affiliation: CHU Clermont-Ferrand, Centre Régional de Cancérologie et Thérapie Cellulaire Pédiatrique, Clermont-Ferrand, France.
authors.forename: G
authors.initials: G
authors.lastname: Remérand
authors.forename: E
authors.initials: E
authors.lastname: Merlin
authors.forename: R
authors.initials: R
authors.lastname: Froissart
authors.forename: F
authors.initials: F
authors.lastname: Brugnon
authors.forename: J
authors.initials: J
authors.lastname: Kanold
authors.forename: L
authors.initials: L
authors.lastname: Janny
authors.forename: F
authors.initials: F
authors.lastname: Deméocq
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007231:Infant, Newborn; D008059:Mucopolysaccharidosis I / Q000150:complications* / Q000235:genetics / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000235:genetics; D011256:Pregnancy Outcome; D055815:Young Adult