[Studies and application of fluorescence of metacycline enhanced by synergetic effect of beta-cyclodextrin and DBS].
The fluorescence of metacycline enhanced by the synergetic effect of beta-cyclodextrin with anion surfactant sodium dodecylbenzene sulfonate (DBS) was studied. It was found that the fluorescence intensity of metacycline was greatly enhanced in the system of beta-CD-DBS. Based on this a new sensitive method for the determination of metacycline was established. The experiments indicated that MTC-beta-CD-DBS can form 1 : 1 : 1 ternary inclusion complex with apparent stability constant of 1 294 L2 x mol(-2), respectively. The fluorescence intensity was linearly related to the metacycline concentration in the range of 1.7 x 10(-7) to 8.8 x 10(-5) mol x L(-1) with a correlation coefficient of 0.996 6. The detection limit was 7.4 x 10(-9) mol x L(-1) this method was satisfactorily applied to the determination of metacycline in pharmaceutical preparations. The recovery was within the range of 95% to 106%.
Ao
Deng-Gaowa
DG
College of Chemistry and Chemical Engineering, Inner Mongolia University, Huhhot 010021, China. hxgaowa@126.com
Si
Qin
Q
D001557:Benzenesulfonates / Q000737:chemistry*; D008690:Methacycline / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D047392:beta-Cyclodextrins / Q000737:chemistry*
D001557:Benzenesulfonates; D047392:beta-Cyclodextrins; C001114:dodecylbenzenesulfonic acid; D008690:Methacycline; C031215:betadex