title: Salt impregnation of implant materials.
abstract: Implant infection and peri-implantitis are recurrent and serious complications in implantology. Antibiotic treatment of infected implants in bone is complicated because of limited vascularization of the surrounding tissue on the one hand, and biofilm formation on the implant surface on the other. Therefore, contamination of the implant surface has to be prevented. For this purpose we developed a method of coating Ti6Al4V samples with NaCl in order to reduce the water activity on the sample surface. The resulting NaCl-coated surfaces showed good biocompatibility with osteoblastlike cells and resulted in a significant reduction of bacterial strains. The presented surface modification is hence a promising method to reduce bacterially induced implant failure.
authors.affiliation: Department of Functional Materials in Medicine and Dentistry, Dental School of the University of Würzburg, Würzburg, Germany. andrea.ewald@fmz.uni-wuerzburg.de
authors.forename: Andrea
authors.initials: A
authors.lastname: Ewald
authors.forename: Stefan
authors.initials: S
authors.lastname: Ihde
mesh_terms: D001419:Bacteria / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015169:Colony Count, Microbial; D003758:Dental Implantation, Endosseous / Q000295:instrumentation; D015921:Dental Implants / Q000009:adverse effects* / Q000382:microbiology; D017267:Dental Prosthesis Design; D004866:Equipment Contamination / Q000517:prevention & control*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D010006:Osteoblasts / Q000187:drug effects / Q000648:ultrastructure; D010518:Periodontitis / Q000209:etiology / Q000517:prevention & control*; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000517:prevention & control*; D012965:Sodium Chloride / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D012965:Sodium Chloride; D014025:Titanium