Chromones from the endophytic fungus Pestalotiopsis sp. isolated from the chinese mangrove plant Rhizophora mucronata.
Six new chromones, named pestalotiopsones A-F (1-6), and the known derivative 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (7) were obtained from the mycelia and culture filtrate of the mangrove endophytic fungus Pestalotiopsis sp., which was isolated from leaves of the Chinese Mangrove plant Rhizophora mucronata. Their structures were elucidated on the basis of spectroscopic data. Pestalotiopsones A-F are chromones having both an alkyl side chain substituted at C-2 and a free or substituted carboxyl group at C-5. Compound 6 exhibited moderate cytotoxicity against the murine cancer cell line L5178Y, whereas the other investigated compounds proved to be inactive.
Xu
Jing
J
Institut fur Pharmazeutische Biologie and Biotechnologie, Heinrich-Heine-Universitat, Dusseldorf, Germany.
Kjer
Julia
J
Sendker
Jandirk
J
Wray
Victor
V
Guan
Huashi
H
Edrada
Ruangelie
R
Lin
Wenhan
W
Wu
Jun
J
Proksch
Peter
P
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D043982:Rhizophoraceae / Q000382:microbiology*; D013098:Xylariales / Q000737:chemistry*
D000970:Antineoplastic Agents; D002867:Chromones; D004365:Drugs, Chinese Herbal