title: Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster.
abstract: The blood cells, or hemocytes, in Drosophila participate in the immune response through the production of antimicrobial peptides, the phagocytosis of bacteria, and the encapsulation of larger foreign particles such as parasitic eggs; these immune reactions are mediated by phylogenetically conserved mechanisms. The encapsulation reaction is analogous to the formation of granuloma in vertebrates, and is mediated by large specialized cells, the lamellocytes. The origin of the lamellocytes has not been formally established, although it has been suggested that they are derived from the lymph gland, which is generally considered to be the main hematopoietic organ in the Drosophila larva. However, it was recently observed that a subepidermal population of sessile blood cells is released into the circulation in response to a parasitoid wasp infection. We set out to analyze this phenomenon systematically. As a result, we define the sessile hemocytes as a novel hematopoietic compartment, and the main source of lamellocytes.
authors.affiliation: Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, PO Box 521, H-6701, Szeged, Hungary.
authors.forename: Róbert
authors.initials: R
authors.lastname: Márkus
authors.forename: Barbara
authors.initials: B
authors.lastname: Laurinyecz
authors.forename: Eva
authors.initials: E
authors.lastname: Kurucz
authors.forename: Viktor
authors.initials: V
authors.lastname: Honti
authors.forename: Izabella
authors.initials: I
authors.lastname: Bajusz
authors.forename: Botond
authors.initials: B
authors.lastname: Sipos
authors.forename: Kálmán
authors.initials: K
authors.lastname: Somogyi
authors.forename: Jesper
authors.initials: J
authors.lastname: Kronhamn
authors.forename: Dan
authors.initials: D
authors.lastname: Hultmark
authors.forename: István
authors.initials: I
authors.lastname: Andó
mesh_terms: D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation; D002469:Cell Separation; D004331:Drosophila melanogaster / Q000033:anatomy & histology* / Q000166:cytology / Q000276:immunology*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006410:Hematopoiesis; D006434:Hemocytes / Q000166:cytology* / Q000637:transplantation; D007109:Immunity; D007814:Larva / Q000166:cytology / Q000276:immunology / Q000469:parasitology; D010641:Phenotype; D013997:Time Factors
chemical_list: D049452:Green Fluorescent Proteins