Statins as potential antimalarial drugs: low relative potency and lack of synergy with conventional antimalarial drugs.
The in vitro sensitivity of Plasmodium falciparum to atorvastatin and rosuvastatin was assessed using chloroquine-sensitive and chloroquine-resistant strains. Although atorvastatin was more potent, it had weak activity (mean 50% inhibitory concentration of > or = 17 microM) and an indifferent interaction with chloroquine and dihydroartemisinin. Bioassay of plasma from an atorvastatin-treated subject showed similar results.
Wong
Rina P M
RP
School of Medicine and Pharmacology, University of Western Australia, Nedlands, Western Australia, Australia.
Davis
Timothy M E
TM
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D000069059:Atorvastatin; D002738:Chloroquine / Q000494:pharmacology; D003470:Culture Media; D004351:Drug Resistance; D004357:Drug Synergism; D006538:Heptanoic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D011758:Pyrroles / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology
D000962:Antimalarials; D003470:Culture Media; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D002738:Chloroquine; D000069059:Atorvastatin