title: Subjective cognitive impairment: increased prefrontal cortex activation compared to controls during an encoding task.
abstract: OBJECTIVE
  Subjective cognitive impairment (SCI) has been proposed as a clinical stage which may precede mild cognitive impairment in the clinical continuum of AD, and is characterised by the presence of subjective memory complaints in the absence of objective cognitive deficits. Specific memory-related brain activation differences have been reported in mild cognitive impairment and in cognitively normal individuals at known genetic risk of AD; our objective was to determine whether similar differences are present in people with SCI.
  
  
  METHODS
  We compared brain activation in a memory clinic sample of 10 SCI subjects and 10 controls during a verbal episodic memory encoding task using functional magnetic resonance imaging (fMRI).
  
  
  RESULTS
  There were no differences between groups on measures of encoding success (recognition accuracy) nor was there evidence of altered semantic processing. Both groups activated left prefrontal cortex (PFC) and cerebellum during encoding. The SCI group also demonstrated activation in left medial temporal, occipitoparietal and medial frontal cortex. Group comparisons revealed increased activation in SCI in left PFC, where activation strength correlated with memory task performance.
  
  
  CONCLUSIONS
  The activation differences reported in this study may reflect the employment of compensatory strategies in the face of early AD pathology, although a number of alternative explanations need to be considered. Further studies with larger samples may help to determine whether the observed activation changes are likely to be associated with early neuropathological processes or with other unrelated factors.
authors.affiliation: University College London, Department of Mental Health Sciences, UK. j.rodda@ucl.ac.uk
authors.forename: Joanne E
authors.initials: JE
authors.lastname: Rodda
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Dannhauser
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Cutinha
authors.forename: Sukhwinder S
authors.initials: SS
authors.lastname: Shergill
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Walker
mesh_terms: D000161:Acoustic Stimulation; D000544:Alzheimer Disease / Q000503:physiopathology; D000704:Analysis of Variance; D003072:Cognition Disorders / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology*