Calponin control of cerebrovascular reactivity: therapeutic implications in brain trauma.
Calponin (Cp) is an actin-binding protein first characterized in chicken gizzard smooth muscle (SM). This review discusses the role of Cp in mediating SM contraction, the biochemical process by which Cp facilitates SM contraction and the function of Cp in the brain. Recent work on the role of Cp in pathological states with emphasis on traumatic brain injury is also discussed. Based on past and present data, the case is presented for targeting Cp for novel genetic and pharmacological therapies aimed at improving outcome following traumatic brain injury (TBI).
Kreipke
Christian W
CW
Department of Anatomy and Cell Biology, Wayne State University, Detroit, MI, USA.
Rafols
Jose A
JA
D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D019332:Endothelin-1 / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism*; D009119:Muscle Contraction / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D044022:Receptor, Endothelin A / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D000096985:Calponins
D002135:Calcium-Binding Proteins; D019332:Endothelin-1; D008840:Microfilament Proteins; D044022:Receptor, Endothelin A; D000096985:Calponins