title: Antioxidative iridoid glycosides and phenolic compounds from Veronica peregrina.
abstract: Eight iridoid glycosides and four phenolic compounds were isolated from the EtOAc soluble fraction of Veronica peregrina MeOH extract as the radical scavengers for antioxidant activity. The compounds were identified as protocatechuic acid (1), luteolin (2), veronicoside (3), minecoside (4), specioside (5), amphicoside (6), catalposide (7), 6-O-cis-p-coumaroyl catalpol (8), p-hydroxy benzoic acid methyl ester (9), verproside (10), verminoside (11), and chrysoeriol 7-glucuronide (12) by spectroscopic analysis. All compounds except for 1 and 2 were isolated for the first time from this plant. The antioxidant activity was evaluated by the ORAC(Oxygen Radical Absorbance Capacity) assay, which measures scavenging activity against peroxy radicals induced by 2,2'-azobis (2-methoxypropion-amidine) dihydrochloride, and the ORAC value is expressed as relative trolox equivalent. Compounds 2, 4, 5, 6, 8, and 12 exhibited potent antioxidant activity, and compounds 1, 11 had similar activity with trolox, whereas the other compounds showed weaker activity than trolox.
authors.affiliation: College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea. jhkwak@skku.edu
authors.forename: Jong Hwan
authors.initials: JH
authors.lastname: Kwak
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
authors.forename: Ok Pyo
authors.initials: OP
authors.lastname: Zee
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D039823:Iridoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000737:chemistry; D032264:Veronica / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D006027:Glycosides; D039823:Iridoids; D010636:Phenols; D017382:Reactive Oxygen Species