title: Removal of prostaglandin E2 and increased intraoperative blood pressure during modified ultrafiltration in pediatric cardiac surgery.
abstract: OBJECTIVE
  We investigated the relationship between serum prostaglandin E(2) and intraoperative blood pressure in pediatric cardiac surgery with modified ultrafiltration.
  
  
  METHODS
  In 35 consecutive patients (31.6 +/- 26.8 months, 0.4-111 months, 10.9 +/- 5.5 kg, 2.9-23.8 kg) who underwent cardiac surgery with modified ultrafiltration, we measured intraoperative serum prostaglandin E(2) changes and effluent prostaglandin E(2), assessed the relationship between serum prostaglandin E(2) and intraoperative hemodynamic parameters, and performed subset analyses to compare patients with low (<10 kg, n = 18) and high (>10 kg, n = 10) weights.
  
  
  RESULTS
  During cardiopulmonary bypass, systolic blood pressure decreased from 80.8 +/- 15.2 to 60.5 +/- 11.3 mm Hg (P = .00000002979) and serum prostaglandin E(2) increased from 16.6 +/- 8.7 to 58.8 +/- 53.3 pg/mL (P = .002). During modified ultrafiltration, although central venous pressure and catecholamine dosage transited at the same levels, systolic blood pressure increased from 60.5 +/- 11.3 to 83.4 +/- 14.1 mm Hg (P = .00000002979) and serum prostaglandin E(2) decreased from 58.8 +/- 53.3 to 21.1 +/- 11.6 pg/mL (P = .001), with negative correlation between serum prostaglandin E(2) and systolic blood pressure (R = -0.392, P = .0000277723) and 15,700 +/- 10,700 pg (1790 +/- 2230 pg/kg) prostaglandin E(2) removed during modified ultrafiltration. Decrease in serum prostaglandin E(2) was significantly higher in low-weight patients (51.8 +/- 58.4 pg/mL) than in high-weight patients (15.7 +/- 30.1 pg/mL).
  
  
  CONCLUSIONS
  Removal of prostaglandin E(2) is one reason for increased blood pressure during modified ultrafiltration, with the effect more marked in low-weight patients.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Mie University Graduate School of Medicine, Tsu, Japan.
authors.forename: Kazuto
authors.initials: K
authors.lastname: Yokoyama
authors.forename: Shin
authors.initials: S
authors.lastname: Takabayashi
authors.forename: Takuya
authors.initials: T
authors.lastname: Komada
authors.forename: Koji
authors.initials: K
authors.lastname: Onoda
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Mitani
authors.forename: Hideki
authors.initials: H
authors.lastname: Iwata
authors.forename: Hideto
authors.initials: H
authors.lastname: Shimpo
mesh_terms: D001794:Blood Pressure; D002315:Cardiopulmonary Bypass; D002648:Child; D015232:Dinoprostone / Q000097:blood*; D006440:Hemofiltration / Q000379:methods; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007432:Intraoperative Period
chemical_list: D015232:Dinoprostone