title: Apoptotic signaling cascades operating in poliovirus-infected cells.
abstract: The flaccid paralyses characteristic of poliomyelitis are a direct consequence of the infection of motor neurons with poliovirus (PV). In PV-infected mice, motor neurons die by apoptosis. However, the mechanisms by which PV induces cell death in neurons remain unclear. Analyses of the apoptotic pathways induced by PV infection in several cell lines have demonstrated that mitochondria play a key role in PV-induced apoptosis. Furthermore, mitochondrial dysfunction results from an imbalance between pro- and anti-apoptotic pathways. We present here an overview of the many studies of PV-induced apoptosis carried out in recent years and discuss the contribution of these studies to our understanding of poliomyelitis.
authors.affiliation: Biologie des Virus Enteriques, Institut Pasteur, 28 rue du Docteur Roux, 75724 Paris cedex 15, France. bblondel@pasteur.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Blondel
authors.forename: Arnaud
authors.initials: A
authors.lastname: Autret
authors.forename: Cynthia
authors.initials: C
authors.lastname: Brisac
authors.forename: Sandra
authors.initials: S
authors.lastname: Martin-Latil
authors.forename: Laurence
authors.initials: L
authors.lastname: Mousson
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pelletier
authors.forename: Jerome
authors.initials: J
authors.lastname: Estaquier
authors.forename: Florence
authors.initials: F
authors.lastname: Colbere-Garapin
mesh_terms: D000818:Animals; D017209:Apoptosis; D006801:Humans; D017955:Poliovirus / Q000502:physiology*; D015398:Signal Transduction; D014779:Virus Replication