Effect of sublingual medication of sildenafil citrate/ apomorphine on sexual behaviour of male rats.
The study investigated the combined effect of sublingually administered sildenafil (SN) and apomorphine (APO SL) on the sexual behaviour of male rats. Male Sprague-Dawley rats (50) were divided into five groups (10 rats per each group): blank control, sildenafil group and SN plus APO SL high dosage, medium dosage and low dosage group. After sublingual administration of the agents (control and SN plus APO SL) and a sole dosage of sildenafil (stomach irrigation), the rats were mated with female counterparts in pairs, and the latent period of chasing, the frequency of chasing in 60 min, the latent period of mounting and the frequency of mounting in 60 min were recorded. The lower dosage of SN plus APO SL exerted a stronger influence on the sexual activities in male rats than did the higher sole dosage of sildenafil. Identification of common neurochemical and neuroanatomical substrates of sexual responding between animals and humans suggests that the evolution of sexual behaviour has been highly conserved and indicates that animal models of human sexual response can be used successfully as pre-clinical tools. So sublingual medication of SN combined with APO SL may be at least a support inference about male sexual libido.
Huang
X
X
Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. huangxb@mails.tjmu.edu.cn
Xiong
C
C
Zhou
J
J
Shen
J
J
D000286:Administration, Sublingual; D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D008297:Male; D023421:Models, Animal; D010879:Piperazines / Q000008:administration & dosage*; D011687:Purines / Q000008:administration & dosage; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000008:administration & dosage*
D004338:Drug Combinations; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D001058:Apomorphine