title: Intravenous immune globulin usage for neurological and neuromuscular disorders: an academic centre, 4 years experience.
abstract: Intravenous immune globulin (IVIg) use for labeled and unlabeled indications has grown in the last years. Aim of this study was to evaluate the IVIg usage profile for neurological inpatients in a single academic medical centre, over a long period of time. We retrospectively reviewed all approved IVIg transfusions for neurological disorders at Careggi Hospital from 2003 to 2006. The pharmacy records were then cross-referenced with patient medical records to determine the indication for IVIg administration. From 2003 to 2006 we observed a tremendous increase in IVIg administration, in the annual number of treated patients and in the mean annual courses. Fifty-seven patients (24%) received a long-term IVIg treatment, which accounted for 61% of the total IVIg consumption. The use of IVIg continues to expand despite concerns on future availability and long-term safety; alternative treatment strategies in chronic neurological disorders which require long-term, potentially indefinite therapy are warranted.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Firenze, Viale Morgagni, 85, 50138, Florence, Italy.
authors.forename: Lisa
authors.initials: L
authors.lastname: Sarti
authors.forename: Tiziana
authors.initials: T
authors.lastname: Falai
authors.forename: Francesco
authors.initials: F
authors.lastname: Pinto
authors.forename: Enrico
authors.initials: E
authors.lastname: Tendi
authors.forename: Sabrina
authors.initials: S
authors.lastname: Matà
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004363:Drug Utilization / Q000706:statistics & numerical data / Q000639:trends; D017723:Drug Utilization Review; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors; D007167:Immunotherapy / Q000639:trends; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000145:classification / Q000188:drug therapy*; D009468:Neuromuscular Diseases / Q000145:classification / Q000188:drug therapy*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D016756:Immunoglobulins, Intravenous; D007155:Immunologic Factors