title: Primary cutaneous anaplastic large cell lymphoma of the medial canthus and orbit.
abstract: A 59-year-old man sought evaluation for a rapidly enlarging, nontender, ulcerated right medial canthal lesion unresponsive to antibiotics. Biopsy revealed CD30+ anaplastic large cell lymphoma. CT demonstrated contiguous spread in the orbit. Systemic evaluation for lymphoma was negative, and he underwent local radiotherapy. The lesion regressed completely, and he has remained disease free for 7 months. CD30+ anaplastic large cell lymphoma of the periocular skin and orbit are usually distinct, exceedingly rare entities; no reported cases had simultaneous involvement of both tissues. The authors present the first reported case, to their knowledge, of simultaneous skin and orbital involvement by anaplastic large cell lymphoma.
authors.affiliation: Department of Ophthalmology, University of Michigan, Ann Arbor, Michigan 48105, USA.
authors.forename: Irina V
authors.initials: IV
authors.lastname: Koreen
authors.forename: Raymond I
authors.initials: RI
authors.lastname: Cho
authors.forename: Bartley R
authors.initials: BR
authors.lastname: Frueh
authors.forename: Victor M
authors.initials: VM
authors.lastname: Elner
mesh_terms: D017252:CD3 Complex / Q000032:analysis; D005142:Eyelid Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D006801:Humans; D007124:Immunoenzyme Techniques; D017730:Ki-1 Antigen / Q000032:analysis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed
chemical_list: D017252:CD3 Complex; D017730:Ki-1 Antigen