Spatial patterns in discordant diagnostic test results for Chagas disease: links to transmission hotspots.
Diagnosis of Chagas disease is hindered by discordance between screening and confirmatory test results for Trypanosoma cruzi infection. In periurban Arequipa, Peru, spatial analysis revealed that individuals with discordant test results are spatially clustered in hotspots of T. cruzi transmission, suggesting that discordant results likely represent true infections in this setting.
Levy
Michael Z
MZ
Fogarty International Center, National Institutes of Health, Bethesda, Maryland, USA. mzlevy@sas.upenn.edu
Bowman
Natalie M
NM
Kawai
Vivian
V
Plotkin
Joshua B
JB
Waller
Lance A
LA
Cabrera
Lilia
L
Steurer
Frank
F
Seitz
Amy E
AE
Pinedo-Cancino
Viviana V
VV
Cornejo del Carpio
Juan Geny
JG
Cordova Benzaquen
Eleazar
E
McKenzie
F Ellis
FE
Maguire
James H
JH
Gilman
Robert H
RH
Bern
Caryn
C
D000818:Animals; D014355:Chagas Disease / Q000175:diagnosis* / Q000453:epidemiology* / Q000635:transmission; D016000:Cluster Analysis; D003198:Computer Simulation; D004797:Enzyme-Linked Immunosorbent Assay; D005455:Fluorescent Antibody Technique; D006801:Humans; D008954:Models, Biological; D009010:Monte Carlo Method; D010568:Peru / Q000453:epidemiology; D015531:Radioimmunoprecipitation Assay; D013997:Time Factors; D019371:Topography, Medical; D014349:Trypanosoma cruzi / Q000302:isolation & purification*