title: Hair growth regulation by the extract of aromatic plant Erica multiflora.
abstract: Hair growth problems can affect human physical and mental health and are of particular relevance during the aging process. In an effort to resolve such problems, we attempted to find plants having hair growth regulation activity and thus collected plant extracts from Tunisia for bioprospecting purposes. Among them, we investigated the Erica multiflora extract to evaluate the hair growth promotion activity by using the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) assay and cell cycle assay on human dermal papilla cells in vitro and an administration assay on mouse dorsal skin in vivo. The results showed that the Erica multiflora extract promotes dermal papilla cell growth and cell cycle with high activity, and induced hair growth in vivo by induction of anagen phase from telogen phase.
authors.affiliation: Alliance for Research on North Africa, Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8572, Japan.
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Kawano
authors.forename: Junkyu
authors.initials: J
authors.lastname: Han
authors.forename: Mohamed Elyes
authors.initials: ME
authors.lastname: Kchouk
authors.forename: Hiroko
authors.initials: H
authors.lastname: Isoda
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D029791:Ericaceae / Q000737:chemistry*; D006197:Hair / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D012867:Skin / Q000166:cytology / Q000187:drug effects*
chemical_list: D010936:Plant Extracts