ERGs in children with pancreatic enzyme insufficient and pancreatic enzyme sufficient cystic fibrosis.
OBJECTIVE
We recorded scotopic and photopic flash electroretinograms (ERGs) in pediatric subjects with cystic fibrosis, aged 4 to 18 years, who were either pancreatic insufficient (PI) or pancreatic sufficient (PS). The aim of the study was to determine whether vitamin supplementation in the PI group allowed comparable retinal function in these two groups.


METHODS
ERGs were recorded from a mixed-gender group of 41 children and adolescents (4 to 17 years of age) with cystic fibrosis. The subjects were grouped according to pancreatic function into PI (n = 29) and PS (n = 12). Full-field flash ERGs were recorded from one eye using a DTL fiber. The pupil was dilated prior to recording using two drops of 0.5% tropicamide. ISCEV photopic and scotopic stimuli and recording conditions were used. Serum levels of vitamin A, beta carotene and retinol binding protein (RBP) were measured on the day of ERG recording.


RESULTS
There was no significant difference in ERG amplitudes or implicit times between PI and PS groups. Vitamin A, beta carotene, and RBP levels were not significantly different across the two groups and were not correlated with implicit times or amplitudes of any of the ERG types recorded here.


CONCLUSIONS
Similarity of ERGs across the PI and PS cystic fibrosis patient populations tested here suggests that the supplementation protocol applied to these populations allows similar levels of retinal function (as indicated by flash ERG parameters) in the two groups.
Whatham
Andrew
A
University of New South Wales, Sydney, Australia. Andrew.Whatham@gmail.com
Suttle
Catherine
C
Blumenthal
Caron
C
Allen
Jane
J
Gaskin
Kevin
K
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000201:enzymology / Q000503:physiopathology*; D004596:Electroretinography / Q000379:methods; D004798:Enzymes / Q000172:deficiency / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010179:Pancreas / Q000201:enzymology*; D012160:Retina / Q000503:physiopathology*; D012177:Retinol-Binding Proteins / Q000378:metabolism; D014801:Vitamin A / Q000097:blood; D019207:beta Carotene / Q000097:blood
D004798:Enzymes; D012177:Retinol-Binding Proteins; D019207:beta Carotene; D014801:Vitamin A