title: Responses of Pseudomonas to small toxic molecules by a mosaic of domains.
abstract: Transcriptional responses of microorganisms to environmental perturbations are broad and complex, and often involve regulatory cascades in which an interplay of regulatory factors trigger a specific expression program. Here, we describe how Pseudomonas responds to challenges from toxic chemicals, for which they use a dedicated program that subsequently confers resistance to these compounds. A mosaic of domains has been recruited to sense and metabolize these chemicals in order to obtain energy and carbon.
authors.affiliation: Consejo Superior de Investigaciones Científica, Estación Experimental del Zaidín, Department of Environmental Protection, Granada, Spain. jlramos@eez.csic.es
authors.forename: Juan L
authors.initials: JL
authors.lastname: Ramos
authors.forename: Tino
authors.initials: T
authors.lastname: Krell
authors.forename: Craig
authors.initials: C
authors.lastname: Daniels
authors.forename: Ana
authors.initials: A
authors.lastname: Segura
authors.forename: Estrella
authors.initials: E
authors.lastname: Duque
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism; D004785:Environmental Pollutants / Q000378:metabolism* / Q000633:toxicity; D006841:Hydrocarbons, Aromatic / Q000378:metabolism / Q000633:toxicity; D011494:Protein Kinases / Q000378:metabolism; D016958:Pseudomonas putida / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D004785:Environmental Pollutants; D006841:Hydrocarbons, Aromatic; D014157:Transcription Factors; C074322:XylR protein, Pseudomonas; D011494:Protein Kinases; C104649:TodS protein, Pseudomonas putida