A randomized clinical trial to compare plaque inhibition of a sodium fluoride/potassium nitrate dentifrice versus a stabilized stannous fluoride/sodium hexametaphosphate dentifrice.
OBJECTIVE
To compare the plaque inhibition efficacy of a sodium fluoride/potassium nitrate (NaF/KNO3 with 1450 ppm F) test dentifrice to a 0.454% stannous fluoride/sodium hexametaphosphate/sodium fluoride positive control dentifrice (SnF2/SHMP with 1450 ppm F).


METHODS
Twenty-five subjects were randomized to a two-period, two-treatment, double blind crossover sequence using NaF/KNO3 (Sensodyne ProNamel dentifrice) and SnF2/SHMP (blend-a-med* EXPERT GUMS PROTECTION dentifrice). Each treatment was conducted with a standard manual toothbrush (Oral-B P35 Indicator). Digital plaque image analysis (DPIA) was used on three consecutive days to evaluate: (a) overnight plaque formation (A.M. pre-brushing); (b) following 40 seconds of brushing with the test product (A.M. post-brushing); and (c) mid-afternoon (P.M.). Images were analysed using an objective computer algorithm to calculate the total area of visible plaque. A four-day washout period was instituted for the crossover phase.


RESULTS
All 25 subjects completed the study. The SnF2/SHMP positive control dentifrice provided statistically significantly lower levels of plaque area coverage versus the NaF/KNO3 test dentifrice at each timepoint. For the SnF2/SHMP dentifrice, plaque coverage was 23.0% lower (p< 0.0001) at A.M. pre-brushing, 17.3% (p= 0.0163) lower at A.M. post-brushing, and 22.6% (p= 0.0004) lower at the P.M. measure relative to the NaF/KNO3 dentifrice.


CONCLUSIONS
The SnF2/SHMP dentifrice (blend-a-med EXPERT GUMS PROTECTION) inhibits plaque regrowth both overnight and during the day to a significantly greater degree than the NaF/KNO3 dentifrice (Sensodyne ProNamel).


CONCLUSIONS
Dentists recommending an effective home use dentifrice for patients experiencing dentinal hypersensitivity and/or dental erosion may previously have needed to compromise on other key benefits, such as plaque control. blend-a-med EXPERT GUMS PROTECTION is a dentifrice when integrated into an oral hygiene routine can provide a proven treatment for hypersensitivity, dental erosion, and a reduction in the regrowth of plaque.
Bellamy
Philip G
PG
Oral Care Research and Development, London Innovation Centre of the Procter & Gamble Company in Egham, Surrey, UK. bellamy.pg@pg.com
Khera
Nichelle
N
Day
Trevor N
TN
Barker
Matthew L
ML
Mussett
Andrew J
AJ
D000328:Adult; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003481:Cuspid / Q000473:pathology; D003773:Dental Plaque / Q000473:pathology / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D019793:Fluorescein; D005456:Fluorescent Dyes; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007180:Incisor / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000008:administration & dosage / Q000627:therapeutic use*; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D017680:Potassium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D014099:Toothbrushing / Q000295:instrumentation
D002327:Cariostatic Agents; D004338:Drug Combinations; D005456:Fluorescent Dyes; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; D014002:Tin Fluorides; D012969:Sodium Fluoride; C009285:sodium polymetaphosphate; C023844:potassium nitrate; D019793:Fluorescein