Studies on quinones. Part 45: novel 7-aminoisoquinoline-5,8-quinone derivatives with antitumor properties on cancer cell lines.
A variety of 7-aminoisoquinoline-5,8-quinone derivatives were prepared from 2,5-dihydroxyacetophenone, methyl aminocrotonate, and the corresponding amines, through a highly efficient three-step sequence. The members of this series were tested on normal human fibroblasts and on a panel of three human cancer cell lines and their redox properties were determined by cyclic voltammetry in acetonitrile. Both the cytotoxicity and antitumor activity of 7-phenylaminoisoquinoline-5,8-quinone derivatives showed correlation with their half wave potentials and lipophilicities.
Valderrama
Jaime A
JA
Facultad de Quimica, Pontificia Universidad Católica de Chile, Casilla 306, Santiago, Chile. jvalderr@uc.cl
Ibacache
J Andrea
JA
Arancibia
Verónica
V
Rodriguez
Jaime
J
Theoduloz
Cristina
C
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D011809:Quinones / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*
D000970:Antineoplastic Agents; D011809:Quinones