Effect of quercetin on the gene expression profile of the mouse intestine.
BALB/c mice were administered with quercetin or its derivatives (quercetin-3-glucoside, quercetin-4'-glucoside and rutin, 5 or 50 mg/kg BW) for 2 weeks. The mucosa of the small intestine were recovered and subjected to a microarray analysis using Affymetrix Mouse Genome 430 2.0 Array. A cluster analysis shows that only the "low dose group" had a significantly different gene expression profile from the negative control group.
Natsume
Yayoi
Y
Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Toky, Japan.
Kadota
Koji
K
Satsu
Hideo
H
Shimizu
Makoto
M
D000818:Animals; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011794:Quercetin / Q000494:pharmacology*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
D012333:RNA, Messenger; D011794:Quercetin