title: Osler vindicated: glioma of the leg center with Jacksonian epilepsy; removal and cure, with a 50-year follow-up. Historical vignette.
abstract: On December 14, 1883, William Osler, then pathologist at the Montreal General Hospital, presented the specimen of a brain with an almond-sized glioma beneath the right motor cortex to the Montreal Medico-Chirurgical Society. The brain specimen was from a young woman who had suffered from intermittent Jacksonian seizures for 14 years and had eventually died in status epilepticus. Aware of the pioneering removal of a tumor from the cortex reported on in 1885 by Bennett and Godlee, Osler wrote of his case, "this was an instance in which operation would have been justifiable and possibly have been the means of saving life." In 1953, a young man with Jacksonian attacks that began in his foot underwent removal of a Grade I glioma from the central fissure. The operation was performed in an awake craniotomy during which cortical mapping was used to define the motor and sensory cortices. Treatment with focal radiation followed, and afterward the patient became seizure-free, stopped taking anticonvulsant medication, and has led an active life over the past 50 years. Reference is made to the experiences of Sherrington, Cushing, and Penfield with cortical stimulation in the awake patient under regional anesthesia as an effective aid to surgery for epileptogenic lesions, tumors, and vascular malformations. Their technique allows for maximal resection with minimal neurological deficits. Over the past 20 years, this approach has been adopted effectively in many neurosurgical centers.
authors.affiliation: Montreal Neurological Institute and Hospital, McGill University, Montreal, Québec, Canada. william.feindel@mcgill.ca
authors.forename: William
authors.initials: W
authors.lastname: Feindel
mesh_terms: D001932:Brain Neoplasms / Q000150:complications / Q000266:history* / Q000601:surgery; D002170:Canada; D005260:Female; D005910:Glioma / Q000150:complications / Q000266:history / Q000601:surgery; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D008297:Male; D009493:Neurosurgery / Q000266:history; D012640:Seizures / Q000209:etiology / Q000266:history* / Q000601:surgery; D014481:United States