title: Implication of GAB2 gene polymorphism in Italian patients with Alzheimer's disease.
abstract: A common polymorphism (rs2373115) in the GRB-associated binding protein 2 (GAB2) gene has been recently associated with the risk of developing Alzheimer's disease (AD) in 644 apolipoprotein E (ApoE) epsilon4 carriers. In order to assess the involvement of the GAB2 polymorphism in the risk of developing AD, we analyzed the genotype and allele distributions of the GAB2 rs2373115 polymorphism in 579 Italian subjects. Our results support a possible implication of GAB2 genetic variant in AD. However, the observed association was confined to ApoE epsilon4 non-carriers, thus suggesting a possible role of GAB2 as an independent risk factor for AD.
authors.affiliation: Department of Neurological and Psychiatric Sciences, University of Florence and Centro di Ricerca, Trasferimento e Alta Formazione DENOTHE, University of Florence, Firenze, Italy. nacmias@unifi.it
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
authors.forename: Andrea
authors.initials: A
authors.lastname: Tedde
authors.forename: Silvia
authors.initials: S
authors.lastname: Bagnoli
authors.forename: Elena
authors.initials: E
authors.lastname: Cellini
authors.forename: Bianca Maria
authors.initials: BM
authors.lastname: Guarnieri
authors.forename: Silvia
authors.initials: S
authors.lastname: Piacentini
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D001057:Apolipoproteins E; C490895:GAB2 protein, human