Cytotoxic prenylated flavonoids from the stem bark of Maackia amurensis.
Five new prenylated flavonoids, maackiaflavanone A (1), maackiaflavanone B (2), maackiapentone (3), maackiapterocarpan A (4), maackiapterocarpan B (5) along with eleven known flavonoids were isolated from the stem bark of Maackia amurensis. The structures of the new compounds were elucidated by spectroscopic methods. The cytotoxicities of compounds 1-4, 6, 8-12 and 14-16 against four human cancer cell lines, A375S2, HeLa, MCF-7 and HepG2, were tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method. Among the compounds tested, compound 2 showed the strongest cytotoxic activity with IC(50) value of 7.8 microM against A375S2 and euchrenone b(1) showed the most potent cytotoxicity with IC(50) value of 4.5 microM against HeLa.
Li
Xiong
X
School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
Wang
Dong
D
Xia
Ming-Yu
MY
Wang
Zhi-Hui
ZH
Wang
Wei-Ning
WN
Cui
Zheng
Z
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D029901:Maackia / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry*; D054876:Prenylation
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids