title: Polypyrrole nanotubes conjugated with human olfactory receptors: high-performance transducers for FET-type bioelectronic noses.
abstract: Get a whiff of this: Human olfactory receptor (hOR)-conjugated polypyrrole (PPy) nanotubes were integrated into the field-effect transistor (FET) sensor platform for the fabrication of high-performance bioelectronic noses (see picture, S = source, D = drain). The device can translate and amplify hOR-odorant interaction into a detectable signal, and it showed highly sensitive and specific responses toward a target odorant.
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangno, Gwanakgu, Seoul 151-742, Korea.
authors.forename: Hyeonseok
authors.initials: H
authors.lastname: Yoon
authors.forename: Sang Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Oh Seok
authors.initials: OS
authors.lastname: Kwon
authors.forename: Hyun Seok
authors.initials: HS
authors.lastname: Song
authors.forename: Eun Hae
authors.initials: EH
authors.lastname: Oh
authors.forename: Tai Hyun
authors.initials: TH
authors.lastname: Park
authors.forename: Jyongsik
authors.initials: J
authors.lastname: Jang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation* / Q000379:methods; D002087:Butyrates / Q000032:analysis / Q000737:chemistry; D004566:Electrodes; D004581:Electronics / Q000295:instrumentation / Q000379:methods; D006801:Humans; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009666:Nose / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D018035:Receptors, Odorant / Q000737:chemistry* / Q000378:metabolism; D014173:Transistors, Electronic
chemical_list: D002087:Butyrates; C514887:OR2AG1 protein, human; D011108:Polymers; D011758:Pyrroles; D018035:Receptors, Odorant; C067635:polypyrrole; C046390:n-amyl butyrate