Low-dose aspirin therapy to prevent ovarian hyperstimulation syndrome.
OBJECTIVE
To evaluate the effect of low-dose aspirin therapy on ovarian hyperstimulation syndrome (OHSS) in an unselected group of patients undergoing in vitro fertilization (IVF).


METHODS
Randomized clinical trial.


METHODS
Division of Reproductive Medicine at the Department of Obstetrics and Gynecology, University of Pécs, Faculty of Medicine, Pécs, Hungary.


METHODS
Patients who underwent IVF between 2000 and 2006.


METHODS
Initiation of 3154 IVF cycles, for which gonadotropin-releasing hormone agonist was used in 2425 cycles; 1503 cycles randomly selected for low-dose aspirin treatment starting from the first day of controlled ovarian hyperstimulation compared with no treatment in the remaining 922 cycles.


METHODS
The incidence of severe or critical OHSS and the rate of clinical pregnancy.


RESULTS
During this time period, 45 cases of severe OHSS were detected. Only two of the OHSS patients had received aspirin previously.


CONCLUSIONS
Based on our preliminary results, introduction of low-dose aspirin therapy during ovulation induction for the prevention of OHSS in high-risk patients should be considered.
Várnagy
Akos
A
Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Pécs, H-7624 Pécs, Hungary. akos.varnagy@aok.pte.hu
Bódis
József
J
Mánfai
Zoltán
Z
Wilhelm
Ferenc
F
Busznyák
Csaba
C
Koppán
Miklós
M
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D001241:Aspirin / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005307:Fertilization in Vitro / Q000706:statistics & numerical data; D006801:Humans; D016471:Ovarian Hyperstimulation Syndrome / Q000145:classification / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin