title: A myeloproliferative disorder may hide another one.
abstract: Chronic myeloproliferative disorders (MPDs) are divided into Philadelphia-positive chronic myeloid leukemia (CML) and Philadelphia-negative disorders including polycythemia vera, essential thrombocythemia and idiopathic myelofibrosis (IMF). Concomitance of a CML and another MPD is a rare event. We report here the case of a patient presenting initially with IMF who developed a Philadelphia-positive CML 7 years later. At the time of CML diagnosis, two distinct clones were present, one with a 13q deletion and one with a t(9;22). We raise the problem of a CML developing on an initial IMF, or two MPDs occurring from a common or two different stem cells.
authors.affiliation: Département de Biopathologie, Institut Paoli-Calmettes, Centre de Recherche en Cancérologie de Marseille Marseille, France.
authors.forename: Sophy
authors.initials: S
authors.lastname: Laibe
authors.forename: Zoulika
authors.initials: Z
authors.lastname: Tadrist
authors.forename: Christine
authors.initials: C
authors.lastname: Arnoulet
authors.forename: Danielle
authors.initials: D
authors.lastname: Sainty
authors.forename: Marie-Joëlle
authors.initials: MJ
authors.lastname: Mozziconacci
mesh_terms: D000368:Aged; D002872:Chromosome Deletion; D002882:Chromosomes, Human, Pair 13; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive; D008297:Male; D010677:Philadelphia Chromosome; D055728:Primary Myelofibrosis / Q000150:complications* / Q000235:genetics / Q000473:pathology; D013234:Stem Cells / Q000473:pathology; D013997:Time Factors