Translating pathology in multiple sclerosis: the combination of postmortem imaging, histopathology and clinical findings.
BACKGROUND
Studies combining postmortem magnetic resonance imaging (MRI) and histopathology have provided important insights into the abnormalities reflected by MRI.


METHODS
A short overview of these studies applied to multiple sclerosis (MS) is provided in this review, and the Amsterdam postmortem imaging protocol is specifically highlighted.


CONCLUSIONS
Postmortem MRI and histopathology correlation studies have enabled a direct translation of basic pathology in MS to the clinical setting, and have simultaneously served as a biological validation of new MRI techniques.
Seewann
A
A
Department of Neurology, VU University Medical Centre, MS Centre Amsterdam, Amsterdam, The Netherlands.
Kooi
E-J
EJ
Roosendaal
S D
SD
Barkhof
F
F
van der Valk
P
P
Geurts
J J G
JJ
D001921:Brain / Q000473:pathology*; D003952:Diagnostic Imaging; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009103:Multiple Sclerosis / Q000473:pathology*; D011180:Postmortem Changes