title: [Semen descurainiae inhibits CYP11B1, CYP11B2 and TGF-beta1 mRNA expression in left ventricular].
abstract: OBJECTIVE
  To investigate the effects of Semen descurainiae and Captopril on CYP11B1, CYP11B2 and TGF-beta1 mRNA expression of heart tissue in rats treated with Abdominal Aortic Banding.
  
  
  METHODS
  Ventricular remodeling was induced by abdominal aortic banding (AAB) in rats. After 30 days' treatment, the ratios of LVW/BW (left ventricle weight/body weight), HW/BW (heart weight/body weight) were calculated; Then the CYP11B, CYP11B2 and TGF-beta1 mRNA expression of left ventricle were detected by Real-time PCR, respectively.
  
  
  RESULTS
  The experimental data demonstrated that Semen descurainiae decreased the indexes of LVW/BW and HW/BW, down-regulated CYP11B, CYP11B2 and TGF-beta1 mRNA expression in left ventricle (P<0.05).
  
  
  CONCLUSIONS
  Semen desceurainiae can significantly inhibit the experimental ventricular remodeling; the mechanism is related to its ability to attenuate the mRNA expression of CYP11B1, CYP11B2 and TGF-beta1 in left ventricle. The inhibition of aldosterone key gene expression by Semen descurainiae may contribute to its effect on restraint cardiac remodeling.
authors.affiliation: Department of Pharmacology, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. guojuan338@yahoo.com.cn
authors.forename: Juan
authors.initials: J
authors.lastname: Guo
authors.forename: Chang-Xun
authors.initials: CX
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Du
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Gu
authors.forename: Yun-Hui
authors.initials: YH
authors.lastname: Shen
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D019607:Brassicaceae / Q000737:chemistry*; D002312:Cardiomyopathy, Hypertrophic / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010946:Plants, Medicinal / Q000737:chemistry; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry; D013252:Steroid 11-beta-Hydroxylase / Q000235:genetics / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D016212:Transforming Growth Factor beta; D019405:Cytochrome P-450 CYP11B2; D013252:Steroid 11-beta-Hydroxylase