title: The interplay between secondhand cigarette smoke, genetics, and cervical cancer: a review of the literature.
abstract: Research has suggested a link between smoking and cervical cancer; however, little data are available on secondhand smoke (SHS) exposure and cervical cancer risk. This article reviews the literature on the links among smoking, SHS exposure and cervical cancer. The review was based on a search of electronic databases. The research reviewed clearly showed that smoking increases cervical cancer risk through myriad mechanisms that interact with genetics and the pathologic processes leading to cervical cancer. However, less is understood about the role of SHS in cervical cancer. With new technology enabling scientists to examine how genomic structure responds to environmental stimuli, more information should be forthcoming on links between SHS exposure, biomarkers, and genetic changes involved in the development of cervical cancer.
authors.affiliation: University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. NJCapps@uams.edu
authors.forename: Natalie
authors.initials: N
authors.lastname: Pate Capps
authors.forename: Ayasha
authors.initials: A
authors.lastname: Stewart
authors.forename: Cindy
authors.initials: C
authors.lastname: Burns
mesh_terms: D017766:Acid Anhydride Hydrolases / Q000235:genetics; D015703:Antigens, CD / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis; D003043:Cocarcinogenesis; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D019656:Loss of Heterozygosity / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications; D011110:Polymorphism, Genetic / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*; D000097802:CD83 Antigen; D000099170:Bis(5'-adenosyl)triphosphatase
chemical_list: D017766:Acid Anhydride Hydrolases; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D005982:Glutathione Transferase; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D014028:Tobacco Smoke Pollution; D000097802:CD83 Antigen; D000099170:Bis(5'-adenosyl)triphosphatase