title: New cytotoxic phenolic derivatives from matured fruits of Magnolia denudata.
abstract: Magnolia species are widely cultivated in Japan as garden plants, and have been found to contain various compounds, including alkaloids, terpenoids, lignans, and neolignans. The constituents of the mature fruits of M. denudata were investigated, and two new phenolic derivatives, named denudalide and denudaquinol, were isolated and characterized, together with a known neolignan compound (denudatin A). Denudalide and denudaquinol showed cytotoxicity against the SFME and r/mHM-SFME-1 cell lines.
authors.affiliation: Department of Clinical Pharmacy, Aomori University, Kohbata, Aomori, Japan. noshita@aomori-u.ac.jp
authors.forename: Toshiro
authors.initials: T
authors.lastname: Noshita
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
authors.forename: Yumi
authors.initials: Y
authors.lastname: Kidachi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Ryoyama
authors.forename: Shinji
authors.initials: S
authors.lastname: Funayama
authors.forename: Ken
authors.initials: K
authors.lastname: Hanada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Murayama
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D005638:Fruit / Q000737:chemistry* / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry* / Q000254:growth & development; D019800:Phenol / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*
chemical_list: D019800:Phenol