title: An unexpected Bis-ligation of S-nitrosothiols.
abstract: A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This reaction converts unstable primary S-nitrosothiols to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection of S-nitrosation in protein systems.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Jiming
authors.initials: J
authors.lastname: Zhang
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D004220:Disulfides; D007098:Imino Acids; D008722:Methods; D015538:Nitrosation; D010753:Phosphoranes; D011506:Proteins / Q000737:chemistry; D026403:S-Nitrosothiols / Q000737:chemistry*
chemical_list: D004220:Disulfides; D007098:Imino Acids; D010753:Phosphoranes; D011506:Proteins; D026403:S-Nitrosothiols