title: The impact of viral respiratory infection on the severity and recovery from an asthma exacerbation.
abstract: BACKGROUND
  : Viral respiratory illness triggers asthma exacerbations, but the influence of respiratory illness on the acute severity and recovery of childhood asthma is unknown. Our objective was to evaluate the impact of a concurrent acute respiratory illness (based on a clinical definition and PCR detection of a panel of respiratory viruses, Mycoplasma pneumoniae and Chlamydia pneumoniae) on the severity and resolution of symptoms in children with a nonhospitalized exacerbation of asthma.
  
  
  METHODS
  : Subjects were children aged 2 to 15 years presenting to an emergency department for an acute asthma exacerbation and not hospitalized. Acute respiratory illness (ARI) was clinically defined. Nasopharyngeal aspirates (NPA) were examined for respiratory viruses, Chlamydia and Mycoplasma using PCR. The primary outcome was quality of life (QOL) on presentation, day 7 and day 14. Secondary outcomes were acute asthma severity score, asthma diary, and cough diary scores on days 5, 7, 10, and 14.
  
  
  RESULTS
  : On multivariate regression, presence of ARI was statistically but not clinically significantly associated with QOL score on presentation (B = -0.36, P = 0.025). By day 7 and 14, there was no difference between groups. Asthma diary score was significantly higher in children with ARI (B = 0.41, P = 0.039) on day 5 but not on presentation or subsequent days. Respiratory viruses were detected in 54% of the 78 NPAs obtained. There was no difference in the any of the asthma outcomes of children grouped by positive or negative NPA.
  
  
  CONCLUSIONS
  : The presence of a viral respiratory illness has a modest influence on asthma severity, and does not influence recovery from a nonhospitalized asthma exacerbation.
authors.affiliation: Queensland Children's Respiratory Centre, Royal Children's Hospital, Brisbane, Queensland, Australia. annechang@ausdoctors.net
authors.forename: Anne B
authors.initials: AB
authors.lastname: Chang
authors.forename: Ron
authors.initials: R
authors.lastname: Clark
authors.forename: Jason P
authors.initials: JP
authors.lastname: Acworth
authors.forename: Helen L
authors.initials: HL
authors.lastname: Petsky
authors.forename: Theo P
authors.initials: TP
authors.lastname: Sloots
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001249:Asthma / Q000150:complications / Q000453:epidemiology / Q000382:microbiology / Q000821:virology; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D023521:Chlamydophila Infections; D016993:Chlamydophila pneumoniae / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D009177:Mycoplasma pneumoniae; D009305:Nasopharynx / Q000382:microbiology / Q000821:virology; D011019:Pneumonia, Mycoplasma / Q000235:genetics; D012141:Respiratory Tract Infections / Q000150:complications* / Q000453:epidemiology* / Q000382:microbiology / Q000821:virology; D018709:Statistics, Nonparametric; D014777:Virus Diseases / Q000150:complications* / Q000453:epidemiology* / Q000821:virology; D014780:Viruses / Q000235:genetics