title: Semi-synthetic analogs of pinitol as potential inhibitors of TNF-alpha cytokine expression in human neutrophils.
abstract: Semi-synthetic analogs of pinitol were subjected to screening by determining TNF-alpha expression in human neutrophils using flowcytometry. Among the tested compounds, three derivatives displayed more than 50% inhibition of TNF-alpha cytokine secretion in LPS induced stimulated neutrophils and can be considered as potent anti-inflammatory moieties.
authors.affiliation: Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180001, India.
authors.forename: Khurshid A
authors.initials: KA
authors.lastname: Bhat
authors.forename: Bhahwal A
authors.initials: BA
authors.lastname: Shah
authors.forename: Kuldeep K
authors.initials: KK
authors.lastname: Gupta
authors.forename: Anjali
authors.initials: A
authors.lastname: Pandey
authors.forename: Sarang
authors.initials: S
authors.lastname: Bani
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Taneja
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005786:Gene Expression Regulation; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C021730:pinitol; D007294:Inositol