title: Frequency of pelvic lymph node metastases and parametrial involvement in stage IA2 cervical cancer: a population-based study and literature review.
abstract: The frequency of lymph node metastases in stage IA2 cervical cancer is reported to range from 0% to 9.7%. Treatment recommendations vary likewise from a cone biopsy to a Wertheim radical hysterectomy and pelvic lymph node dissection. The objective of this study was to get insight into the true frequency of lymph node metastases and/or parametrial involvement in stage IA2 cervical cancer.
  
  
  METHODS
  : The hospital records of 48 patients with stage IA2 cervical carcinoma who registered from 1994 to 2006 were reviewed, and a literature search was performed.
  
  
  RESULTS
  : Of 48 registered patients, 14 were confirmed to have stage IA2. No lymph node metastases or parametrial invasion and recurrences were found. The collated literature data showed a risk of lymph node metastases of 4.8% (range, 0%-9.7%). The presence of adenocarcinoma and the absence of lymph vascular space invasion resulted in a low risk on lymph node metastases (0.3% and 1.3%, respectively). Parametrial involvement has not been reported.
  
  
  CONCLUSIONS
  : The risk of the selected patients with stage IA2 cervical cancer on lymph node metastases is low. In patients with stage IA2 squamous cell cancer with lymph vascular space invasion, a standard pelvic lymph node dissection should be recommended. Parametrectomy should be included if the nodes are positive. In the other patients, the treatment can be individualized and does not have to include lymph node dissection or parametrectomy.
authors.affiliation: Department of Gynecologic Oncology, Academic Medical Centre, Amsterdam, the Netherlands.
authors.forename: Hannah
authors.initials: H
authors.lastname: van Meurs
authors.forename: Otto
authors.initials: O
authors.lastname: Visser
authors.forename: Marrije R
authors.initials: MR
authors.lastname: Buist
authors.forename: Fibo J W
authors.initials: FJ
authors.lastname: Ten Kate
authors.forename: Jacobus
authors.initials: J
authors.lastname: van der Velden
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009426:Netherlands; D010388:Pelvis; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000473:pathology*