title: Mental-stress-induced platelet activation among patients with coronary artery disease.
abstract: OBJECTIVE
  To study patients with coronary artery disease (CAD) scheduled for coronary angioplasty and to examine platelet activation in response to mental stress as a potential mechanism involved in the association between psychosocial factors and cardiac outcomes. Psychosocial factors have been identified as risk factors for CAD and adverse cardiac outcomes, although the underlying mechanisms are poorly understood.
  
  
  METHODS
  Markers of platelet activation and platelet reactivity in response to experimentally induced mental stress (mental arithmetic and anger recall) were examined, using flow cytometry analysis and beta-thromboglobulin (BTG) assays among 249 CAD patients (age = 60.3 +/- 9.0 years, 15% women) who were scheduled to undergo elective percutaneous coronary intervention.
  
  
  RESULTS
  Mental stress-induced increases in platelet activation (CD41 (GP IIb/IIIa), p = .002; percent of mononuclear cells positive for CD41, p = .01; CD62P (P-selectin) expression, p = .005; and percent platelets positive for CD62P, p < .001). The degree of platelet reactivity was not related to demographic, clinical, or psychological variables, or cardiovascular hemodynamic changes.
  
  
  CONCLUSIONS
  Experimentally induced mental stress induced platelet activation in patients with CAD. This mechanism may partially explain the link between psychosocial variables and the development of adverse cardiac outcomes in patients with CAD.
authors.affiliation: Department of Psychology, University of Western Ontario, Westminster Hall, London ON N6A 3K7, Canada. greid@uwo.ca
authors.forename: Graham J
authors.initials: GJ
authors.lastname: Reid
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seidelin
authors.forename: Willem J
authors.initials: WJ
authors.lastname: Kop
authors.forename: M Jane
authors.initials: MJ
authors.lastname: Irvine
authors.forename: Bradley H
authors.initials: BH
authors.lastname: Strauss
authors.forename: Robert P
authors.initials: RP
authors.lastname: Nolan
authors.forename: Herbert K
authors.initials: HK
authors.lastname: Lau
authors.forename: Erik L
authors.initials: EL
authors.lastname: Yeo
mesh_terms: D000368:Aged; D000786:Anger; D015906:Angioplasty, Balloon, Coronary; D055252:Cell-Derived Microparticles; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000523:psychology / Q000628:therapy; D003863:Depression / Q000097:blood / Q000453:epidemiology; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D011939:Mental Recall; D008875:Middle Aged; D009864:Ontario / Q000453:epidemiology; D015539:Platelet Activation; D011932:Reading; D016037:Single-Blind Method; D012944:Social Support; D013315:Stress, Psychological / Q000097:blood*; D001620:beta-Thromboglobulin / Q000032:analysis
chemical_list: D001620:beta-Thromboglobulin