title: Pregnancy outcome in patients with homozygous sickle cell disease in a university hospital, Eastern Saudi Arabia.
abstract: OBJECTIVE
  To evaluate the maternal and fetal outcome in pregnant women with sickle cell disease and to highlight the complications encountered during pregnancy and delivery at a university hospital in the Eastern Saudi Arabia.
  
  
  METHODS
  A retrospective study of 255 pregnancies in 145 patients with sickle cell disease (SCD) over an 8-year-period analyzed the perinatal complications and maternal and fetal outcomes compared with a control group of 500 Saudi females with the normal hemoglobin phenotype selected randomly that matched for age, parity and delivered during the study period.
  
  
  RESULTS
  The incidence of SCD was 1.3% of all deliveries with one maternal death (0.4%) and a perinatal mortality rate of 78.2/1,000 deliveries in the series. The major maternal complications in the 255 pregnancies were anemia 84.3%, sickle cell crisis 44.3% (26.6% painful and 17.7% hemolytic crises), infection 45.9%, fetal growth restriction 20.1%, preterm delivery 12.6%, and pregnancy-induced hypertension 10.6%. Blood transfusion was necessary in 34% pregnancies. Stillbirths accounted for 63% of the perinatal mortality.
  
  
  CONCLUSIONS
  Saudi women with SCD are at a greater risk of morbidity and mortality in pregnancy than previously reported, with a high perinatal mortality rate. Early booking, meticulous antenatal care and supervised hospital delivery will improve the maternal and fetal outcomes in these patients.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, King Faisal University, Dammam, Saudi Arabia.
authors.forename: Fathia E
authors.initials: FE
authors.lastname: Al Jama
authors.forename: Turki
authors.initials: T
authors.lastname: Gasem
authors.forename: Sameera
authors.initials: S
authors.lastname: Burshaid
authors.forename: Jessica
authors.initials: J
authors.lastname: Rahman
authors.forename: Suleiman A
authors.initials: SA
authors.lastname: Al Suleiman
authors.forename: Mohammad Sayedur
authors.initials: MS
authors.lastname: Rahman
mesh_terms: D000328:Adult; D000740:Anemia / Q000473:pathology; D000755:Anemia, Sickle Cell / Q000473:pathology*; D001724:Birth Weight; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000473:pathology; D007231:Infant, Newborn; D007752:Obstetric Labor, Premature / Q000473:pathology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000473:pathology*; D011256:Pregnancy Outcome; D011295:Prenatal Care / Q000379:methods; D012189:Retrospective Studies; D012529:Saudi Arabia; D055815:Young Adult