Animal models of smoke inhalation induced injuries.
Smoke inhalation injury is the leading cause of mortality from structural fires, as a result of complications such as systemic inflammatory response syndrome and chronic obstructive pulmonary disease, which can be caused by a localized or systemic response. In this review, the pathophysiology of smoke inhalation injury, along with the characteristics found in clinical settings, common animal models, current treatment methods and future potential therapeutics are discussed.
David
Poon
P
Combat Care Laboratory, Combat Care and Performance Programme, Defence Medical and Environmental Research Institute, DSO National Laboratories (Kent Ridge), 27 Medical Drive 09-01, Singapore 117510.
Dunsford
Denny
D
Lu
Jia
J
Moochhala
Shabbir
S
D000818:Animals; D004195:Disease Models, Animal; D019570:Inhalation Exposure; D012137:Respiratory System / Q000293:injuries*; D012906:Smoke / Q000009:adverse effects*
D012906:Smoke