title: Positive associations between ionizing radiation and lymphoma mortality among men.
abstract: The authors investigated the relation between ionizing radiation and lymphoma mortality in 2 cohorts: 1) 20,940 men in the Life Span Study, a study of Japanese atomic bomb survivors who were aged 15-64 years at the time of the bombings of Hiroshima and Nagasaki, and 2) 15,264 male nuclear weapons workers who were hired at the Savannah River Site in South Carolina between 1950 and 1986. Radiation dose-mortality trends were evaluated for all malignant lymphomas and for non-Hodgkin's lymphoma. Positive associations between lymphoma mortality and radiation dose under a 5-year lag assumption were observed in both cohorts (excess relative rates per sievert were 0.79 (90% confidence interval: 0.10, 1.88) and 6.99 (90% confidence interval: 0.96, 18.39), respectively). Exclusion of deaths due to Hodgkin's disease led to small changes in the estimates of association. In each cohort, evidence of a dose-response association was primarily observed more than 35 years after irradiation. These findings suggest a protracted induction and latency period for radiation-induced lymphoma mortality.
authors.affiliation: Department of Epidemiology, University of North Carolina at Chapel Hill, 27599, USA. david.richardson@unc.edu
authors.forename: David B
authors.initials: DB
authors.lastname: Richardson
authors.forename: Hiromi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Steve
authors.initials: S
authors.lastname: Wing
authors.forename: Ritsu
authors.initials: R
authors.lastname: Sakata
authors.forename: Eric
authors.initials: E
authors.lastname: Grant
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Nobuo
authors.initials: N
authors.lastname: Nishi
authors.forename: Susan
authors.initials: S
authors.lastname: Geyer
authors.forename: Midori
authors.initials: M
authors.lastname: Soda
authors.forename: Akihiko
authors.initials: A
authors.lastname: Suyama
authors.forename: Fumiyoshi
authors.initials: F
authors.lastname: Kasagi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kodama
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004781:Environmental Exposure / Q000032:analysis* / Q000706:statistics & numerical data; D004784:Environmental Monitoring / Q000706:statistics & numerical data*; D062665:Epidemiological Monitoring; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008223:Lymphoma / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009689:Nuclear Warfare / Q000706:statistics & numerical data*; D054043:Nuclear Weapons / Q000706:statistics & numerical data*; D011829:Radiation Dosage; D011839:Radiation, Ionizing; D011847:Radioactive Fallout / Q000032:analysis / Q000706:statistics & numerical data*; D013022:South Carolina / Q000453:epidemiology; D016019:Survival Analysis; D015996:Survival Rate; D017741:Survivors / Q000706:statistics & numerical data
chemical_list: D011847:Radioactive Fallout