The interplay between secondhand cigarette smoke, genetics, and cervical cancer: a review of the literature.
Research has suggested a link between smoking and cervical cancer; however, little data are available on secondhand smoke (SHS) exposure and cervical cancer risk. This article reviews the literature on the links among smoking, SHS exposure and cervical cancer. The review was based on a search of electronic databases. The research reviewed clearly showed that smoking increases cervical cancer risk through myriad mechanisms that interact with genetics and the pathologic processes leading to cervical cancer. However, less is understood about the role of SHS in cervical cancer. With new technology enabling scientists to examine how genomic structure responds to environmental stimuli, more information should be forthcoming on links between SHS exposure, biomarkers, and genetic changes involved in the development of cervical cancer.
Pate Capps
Natalie
N
University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. NJCapps@uams.edu
Stewart
Ayasha
A
Burns
Cindy
C
D017766:Acid Anhydride Hydrolases / Q000235:genetics; D015703:Antigens, CD / Q000235:genetics; D014408:Biomarkers, Tumor / Q000032:analysis; D003043:Cocarcinogenesis; D004781:Environmental Exposure / Q000009:adverse effects; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D019656:Loss of Heterozygosity / Q000235:genetics; D008562:Membrane Glycoproteins / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications; D011110:Polymorphism, Genetic / Q000235:genetics; D018570:Risk Assessment; D012307:Risk Factors; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000209:etiology*; D000097802:CD83 Antigen; D000099170:Bis(5'-adenosyl)triphosphatase
D017766:Acid Anhydride Hydrolases; D015703:Antigens, CD; D014408:Biomarkers, Tumor; D005982:Glutathione Transferase; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D014028:Tobacco Smoke Pollution; D000097802:CD83 Antigen; D000099170:Bis(5'-adenosyl)triphosphatase