title: Spontaneous calcium signals induced by gap junctions in a network model of astrocytes.
abstract: The dynamics of a network model of astrocytes coupled by gap junctions is investigated. Calcium dynamics of the single cell is described by the biophysical model comprising the set of three nonlinear differential equations. Intercellular dynamics is provided by the diffusion of inositol 1,4,5-trisphosphate (IP3) through gap junctions between neighboring astrocytes. It is found that the diffusion induces the appearance of spontaneous activity patterns in the network. Stability of the network steady state is analyzed. It is proved that the increase of the diffusion coefficient above a certain critical value yields the generation of low-amplitude subthreshold oscillatory signals in a certain frequency range. It is shown that such spontaneous oscillations can facilitate calcium pulse generation and provide a certain time scale in astrocyte signaling.
authors.affiliation: Institute of Applied Physics of Russian Academy of Science, 46 Uljanov Strasse, 603950 Nizhny Novgorod, Russia. vkazan@neuron.appl.sci-nnov.ru
authors.forename: V B
authors.initials: VB
authors.lastname: Kazantsev
mesh_terms: D001253:Astrocytes / Q000166:cytology* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D017629:Gap Junctions / Q000378:metabolism*; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D009415:Nerve Net / Q000166:cytology / Q000378:metabolism*; D010539:Permeability; D015398:Signal Transduction
chemical_list: D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium