title: Influenza A virus induces p53 accumulation in a biphasic pattern.
abstract: Tumor suppressor p53, the major cellular defense against tumor development, has recently been implicated in host antiviral defense. Previous studies have shown that p53 was induced at the apoptotic stage of influenza virus-infected cells. However, we found that p53 was induced not only at the apoptotic stage but also at the beginning phase of infection, showing a biphasic pattern with a first transient elevation apparent at the beginning phase of infection and a second elevation observable at the middle-late phase of infection. This up-regulation of p53 was independent of increased p53 transcription, but dependent on virus adsorption and replication. The increased p53 was active and able to transactivate its downstream target genes, such as interferon regulatory factor 9 (IRF9) and Bax. To our knowledge, this is the first report to describe a biphasic pattern of p53 accumulation in influenza virus-infected cells.
authors.affiliation: Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Shen
authors.forename: Xiaodu
authors.initials: X
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Qiu
authors.forename: Xiangdong
authors.initials: X
authors.lastname: Li
authors.forename: Hai
authors.initials: H
authors.lastname: Yu
authors.forename: Hua
authors.initials: H
authors.lastname: Xiang
authors.forename: Guangzhi
authors.initials: G
authors.lastname: Tong
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Ma
mesh_terms: D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D002642:Chick Embryo; D004285:Dogs; D006801:Humans; D009980:Influenza A virus / Q000502:physiology*; D007251:Influenza, Human / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D053586:Virus Internalization; D014779:Virus Replication
chemical_list: D016159:Tumor Suppressor Protein p53