Decoding the hemogenic endothelium in mammals.
A collection of recent Nature papers examines the relationship between endothelial precursors and hematopoietic cells. Two of these studies (Eilken et al., 2009; Lancrin et al., 2009) use time-lapse imaging with live markers and genetic analysis of differentiating ESCs to reveal that even non-aortic-derived endothelial cells are hemogenic.
Dieterlen-Lièvre
Françoise
F
UPMC, CNRS UMR7622, Laboratoire de Biologie du Développement, Bat C, 6(ème) étage, Case 24, Paris 75252, Cedex 05, France. francoise.dieterlen@club-internet.fr
Jaffredo
Thierry
T
D000818:Animals; D001808:Blood Vessels / Q000502:physiology*; D002454:Cell Differentiation / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology*; D055018:Hemangioblasts / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D051379:Mice