Enantioselective synthesis of C2-symmetric spirobilactams via Pd-catalyzed intramolecular double N-arylation.
A Pd/BINAP-complex-catalyzed enantioselective intramolecular double N-arylation of malonamides bearing 2-bromoarylmethyl groups furnished C(2)-symmetric spirobi(3,4-dihydro-2-quinolone) derivatives in up to 70% ee.
Takenaka
Kazuhiro
K
The Institute of Scientific and Industrial Research (ISIR), Osaka University, Mihogaoka, Ibaraki, Osaka 567-0047, Japan.
Itoh
Noriyuki
N
Sasai
Hiroaki
H