A sweet path to insulin resistance through PGC-1beta.
Fructose is a highly lipogenic dietary nutrient that has been implicated in the pathogenesis of hyperlipidemia and insulin resistance. In this issue, Nagai et al. (2009) provide in vivo evidence that pinpoints transcriptional coactivator PGC-1beta as a key factor in mediating the metabolic response to fructose intake.
Hernandez
Carlos
C
Life Sciences Institute and Department of Cell & Developmental Biology, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.
Lin
Jiandie D
JD
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004032:Diet; D005632:Fructose / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D016601:RNA-Binding Proteins
D002352:Carrier Proteins; C455622:PPARGC1B protein, human; D016601:RNA-Binding Proteins; D005632:Fructose