Is a history of gestational diabetes related to risk factors for coronary heart disease?
Coronary heart disease (CHD) risk in 20 non-diabetic women with and 20 without a distant history of gestational diabetes (hGDM), matched on age, body mass index, and time since GDM-affected pregnancy, was compared in a case control study. Women with an hGDM had lower high-density lipoprotein cholesterol (HDL-c), p = .02, and higher triglycerides, p < or = .001, versus controls. The combination of high triglycerides and low HDL-c occurred in 25% of hGDM cases versus 0% of controls, p </= .01. Two-hour post-load glucose indicated that 45% of hGDM cases were pre-diabetic versus 20% of controls, p < or = .05. Non-diabetic women with a distant hGDM are at increased risk for DM and may be at increased risk for CHD.
King
Kathleen B
KB
University of Rochester School of Nursing, 601 Elmwood Avenue, Rochester, NY 14642, USA. Kathleen_King@URMC.Rochester.edu
Gerich
John E
JE
Guzick
David S
DS
King
Kathleen U
KU
McDermott
Michael P
MP
D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D048909:Diabetes Complications / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications; D011236:Prediabetic State / Q000209:etiology; D011247:Pregnancy; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol