Sessile hemocytes as a hematopoietic compartment in Drosophila melanogaster.
The blood cells, or hemocytes, in Drosophila participate in the immune response through the production of antimicrobial peptides, the phagocytosis of bacteria, and the encapsulation of larger foreign particles such as parasitic eggs; these immune reactions are mediated by phylogenetically conserved mechanisms. The encapsulation reaction is analogous to the formation of granuloma in vertebrates, and is mediated by large specialized cells, the lamellocytes. The origin of the lamellocytes has not been formally established, although it has been suggested that they are derived from the lymph gland, which is generally considered to be the main hematopoietic organ in the Drosophila larva. However, it was recently observed that a subepidermal population of sessile blood cells is released into the circulation in response to a parasitoid wasp infection. We set out to analyze this phenomenon systematically. As a result, we define the sessile hemocytes as a novel hematopoietic compartment, and the main source of lamellocytes.
Márkus
Róbert
R
Institute of Genetics, Biological Research Center of the Hungarian Academy of Sciences, PO Box 521, H-6701, Szeged, Hungary.
Laurinyecz
Barbara
B
Kurucz
Eva
E
Honti
Viktor
V
Bajusz
Izabella
I
Sipos
Botond
B
Somogyi
Kálmán
K
Kronhamn
Jesper
J
Hultmark
Dan
D
Andó
István
I
D000818:Animals; D002452:Cell Count; D002454:Cell Differentiation; D002469:Cell Separation; D004331:Drosophila melanogaster / Q000033:anatomy & histology* / Q000166:cytology / Q000276:immunology*; D049452:Green Fluorescent Proteins / Q000378:metabolism; D006410:Hematopoiesis; D006434:Hemocytes / Q000166:cytology* / Q000637:transplantation; D007109:Immunity; D007814:Larva / Q000166:cytology / Q000276:immunology / Q000469:parasitology; D010641:Phenotype; D013997:Time Factors
D049452:Green Fluorescent Proteins