Abdominal cysticercosis in a cynomolgus monkey.
Cysticercus tenuicollis, the larval form of Taenia hydatigena, was observed in a 5-year-old male cynomolgus monkey used in a toxicity study for a safety assessment of a pharmaceutical. The animal was born and raised in a primate colony in China. A pale yellow cyst filled with more than 100ml of pale yellow fluid was found in the abdominal cavity in the autopsy. The cyst was found attached to the greater omentum, and it was double layered. Histopathologically, the outer layer was a part of the greater omentum, and the inner layer was the bladder wall of a cysticercus with a well developed scolex. A partial sequence of mitochondrial NADH dehydrogenase subunit 1 showed a high homology to the same region of Taenia hydatigena (1.5-3.3%).
Tsubota
Kenjiro
K
Toxicologic Pathology, Drug Safety Research Labs., Astellas Pharma Inc., 2-1-6 Kashima Yodogawa-ku, Osaka 532-8514, Japan. kenjiro.tsubota@jp.astellas.com
Nakatsuji
Shunji
S
Matsumoto
Masahiro
M
Fujihira
Shiro
S
Yoshizawa
Katsuhiko
K
Okazaki
Yoshimasa
Y
Murakami
Yuichi
Y
Anagawa
Akiko
A
Oku
Yuzaburo
Y
Oishi
Yuji
Y
D000005:Abdomen / Q000469:parasitology*; D000818:Animals; D003551:Cysticercosis / Q000473:pathology / Q000662:veterinary*; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000469:parasitology* / Q000473:pathology