title: Zn(II) complex for selective and rapid scission of protein backbone.
abstract: A ZnII complex with an aldehyde group hydrolyzed porcine pancreatic elastase under mild conditions, pH 8.0, 50 degrees C, by the Schiff base formation between the ZnII complex and the NH2 group in the protein, suggesting that a ZnII compound can be active toward peptide hydrolysis when it strongly binds to the substrate.
authors.affiliation: Department of Nanochemistry, Faculty of Engineering, Tokyo Polytechnic University, Iiyama, 1583, Atsugi, 243-0297, Japan. yashiro@nano.t-kougei.ac.jp
authors.forename: Morio
authors.initials: M
authors.lastname: Yashiro
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Kawakami
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Taya
authors.forename: Suguru
authors.initials: S
authors.lastname: Arai
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujii
mesh_terms: D000818:Animals; D046911:Macromolecular Substances / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D010196:Pancreatic Elastase / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013552:Swine; D015032:Zinc / Q000737:chemistry*
chemical_list: D046911:Macromolecular Substances; D010196:Pancreatic Elastase; D015032:Zinc