title: Use of autologous platelet gel in female pelvic organ prolapse surgery: a feasibility study.
abstract: OBJECTIVE
  We sought to evaluate whether autologous platelet gel (APG) application during anterior colporrhaphy could increase collagen content of the pubocervical fascia and thereby create a more durable repair.
  
  
  METHODS
  Prospective cohort study (Canadian Task Force classification II-2).
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Nine patients undergoing anterior colporrhaphy.
  
  
  METHODS
  We applied APG to the surgical site during anterior colporrhaphy in 9 patients. We collected biopsy specimens from the anterior vaginal wall at surgery and 3 months postoperatively. Collagen content was measured and compared. We evaluated objective and subjective failure rates at 20 months postoperatively.
  
  
  RESULTS
  No significant increase occurred in collagen content at 3 months. Subjective failure rate was 12.5%, objective failure rate was 66.7%, and 1 (12.5%) patient required reoperation 10 months postoperatively.
  
  
  CONCLUSIONS
  The application of APG during anterior colporrhaphy does not seem to increase collagen content or durability of the surgical repair.
authors.affiliation: Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. jeinarsson@partners.org
authors.forename: Jon I
authors.initials: JI
authors.lastname: Einarsson
authors.forename: Kristin
authors.initials: K
authors.lastname: Jonsdottir
authors.forename: Robert
authors.initials: R
authors.lastname: Mandle
mesh_terms: D000328:Adult; D003094:Collagen / Q000378:metabolism; D052858:Cystocele / Q000601:surgery*; D005205:Fascia / Q000502:physiology; D000071938:Fasciotomy; D005240:Feasibility Studies; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D053657:Platelet-Rich Plasma; D014182:Transplantation, Autologous; D013520:Urologic Surgical Procedures / Q000379:methods*
chemical_list: D003094:Collagen