Ancient tRNA synthetase meets modern structural biology.
Use of heavy atoms to calculate the phases in protein X-ray crystallography has now been extended to include site-specific in vivo incorporation of 3-iodo-tyrosine, enabled by the use of an archaeal aminoacyl-tRNA synthetase (Sakamoto et al., 2009).
Schimmel
Paul
P
Guo
Min
M
D000604:Amino Acyl-tRNA Synthetases / Q000737:chemistry*; D019843:Archaeal Proteins / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry; D018360:Crystallography, X-Ray; D008954:Models, Biological; D015202:Protein Engineering; D013379:Substrate Specificity
D019843:Archaeal Proteins; D001426:Bacterial Proteins; D000604:Amino Acyl-tRNA Synthetases