title: Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. (Bowerbank).
abstract: Identification of cytotoxic constituent of Indonesian sponge Kaliapsis sp. has been conducted. The structure identification was judged based on the spectroscopic data, namely, ultraviolet, MS, one and two-dimensional 1H-NMR and 13C-NMR methods. The cytotoxic constituent was identified as 1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)-5-methyl pyrimidine-2,4(1H,3H)-dione. This constituent hasn't been isolated from sponges as natural product.
authors.affiliation: Faculty of Pharmacy, Gadjah Mada University, Sekip Utara, Yogyakarta, Indonesia.
authors.forename: E P
authors.initials: EP
authors.lastname: Setyowati
authors.forename: U A
authors.initials: UA
authors.lastname: Jenie
authors.lastname: Sudarsono
authors.forename: L B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: R
authors.initials: R
authors.lastname: Rahmat
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003603:Cytotoxins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D007214:Indonesia; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013941:Thymine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044366:Transition Temperature
chemical_list: C539903:1-(tetrahydro-4-hydroxy-5-(hydroxymethyl)furan-2-yl)pyrimidine-2,4(1H,3H)-dione; D001688:Biological Products; D003603:Cytotoxins; D005663:Furans; D011743:Pyrimidines; D013941:Thymine