title: [Study on activity and mechanism of Sini Decoction anti-mitochondrial oxidation injury caused by myocardial ischemia/reperfusion].
abstract: OBJECTIVE
  To study the activity and mechanism of Sini Decoction (SND) Anti-mitochondrial Oxidation Injury caused by Myocardial Ischemia/Reperfusion.
  
  
  METHODS
  Kun ming mice were randomly divided into three groups: Control group, Ischemia/Reperfusion (I/R) group and SND-treated group. At the end of experiment,hearts of mice were taken out for further detection. Activity of myocardium and mitochondrial SOD, content of myocardium and mitochondrial MDA, swelling of mitochondria, Lactic Acid content of myocardium and MnSODmRNA expression were observed.
  
  
  RESULTS
  SND could increase the activity of myocardium and mitochondrial SOD (P<0.01), decrease the content of myocardium and mitochondrial MDA (P<0.01), decrease the Lactic Acid content of myocardium, lighted the swelling of mitochondria (P<0.01) and change the expression of MnSODmRNA (P<0.01).
  
  
  CONCLUSIONS
  Sini decoction can anti-mitochondrial oxidation injury caused by Myocardial Ischemia/Reperfusion, its mechanism may be relate to increasing the MnSODmRNA expression.
authors.affiliation: Guangzhou Children's Hospital, Guangzhou 510120, China.
authors.forename: Dan-Yang
authors.initials: DY
authors.lastname: Zhao
authors.forename: Ming-Qi
authors.initials: MQ
authors.lastname: Zhao
authors.forename: Wei-Kang
authors.initials: WK
authors.lastname: Wu
mesh_terms: D031841:Aconitum / Q000737:chemistry; D000818:Animals; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D020939:Zingiber officinale / Q000737:chemistry; D029882:Glycyrrhiza uralensis / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D010946:Plants, Medicinal / Q000737:chemistry; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013482:Superoxide Dismutase / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D012333:RNA, Messenger; D008315:Malondialdehyde; D013482:Superoxide Dismutase