title: Linear growth in relation to the circulating concentration of insulin-like growth factor-I and free thyroxine in infants and children with congenital cyanotic heart disease before vs. after surgical intervention.
abstract: This prospective controlled study recorded the anthropometric data and measured the circulating insulin-like growth factor-I (IGF-I) in 16 children with congenital cyanotic heart disease before and a year after surgical intervention. At presentation patients were significantly shorter [length SD scores (LSDS) = -2.44 +/- 1.31], vs. controls (LSDS = -0.25 +/- 0.18). After surgical treatment the LSDS and growth velocity SD scores (GVSDS) increased significantly to (-) 0.25 +/- 0.95 and 3.7 +/- 2.1, respectively. IGF-I increased from 45.7 +/- 26.3 ng ml(-1) to 67.7 +/- 16.4 ng ml(-1). The GVSDS after treatment was correlated with the body mass index (BMI) (r = 0.339, p < 0.05) and negatively with the LSDS before surgery (r = -0.461, p < 0.05). The percentage increase of IGF-I after operation was correlated significantly with the BMI after surgical intervention (r = 0.82, p < 0.001). It appears that the postoperative growth spurt in infants with cyanotic congenital heart disease (CHD) is mediated through activation of the GH/IGF-I system and improved nutrition.
authors.affiliation: Department of Pediatric Cardiology, Hamad General Hospital, Doha, Qatar.
authors.forename: Amal
authors.initials: A
authors.lastname: El-Sisi
authors.forename: Aiman
authors.initials: A
authors.lastname: Khella
authors.forename: Mohamed
authors.initials: M
authors.lastname: Numan
authors.forename: Mohamed
authors.initials: M
authors.lastname: Dilwar
authors.forename: Akhlaque
authors.initials: A
authors.lastname: Bhat
authors.forename: Ashraf
authors.initials: A
authors.lastname: Soliman
mesh_terms: D000886:Anthropometry; D001827:Body Height; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006128:Growth / Q000502:physiology*; D006330:Heart Defects, Congenital / Q000097:blood / Q000601:surgery*; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D011446:Prospective Studies; D013972:Thyrotropin; D013974:Thyroxine / Q000097:blood*; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D013972:Thyrotropin; D013974:Thyroxine