title: Immunotherapy for liver tumors: present status and future prospects.
abstract: Increasing evidence suggests that immune responses are involved in the control of cancer and that the immune system can be manipulated in different ways to recognize and attack tumors. Progress in immune-based strategies has opened new therapeutic avenues using a number of techniques destined to eliminate malignant cells. In the present review, we overview current knowledge on the importance, successes and difficulties of immunotherapy in liver tumors, including preclinical data available in animal models and information from clinical trials carried out during the lasts years. This review shows that new options for the treatment of advanced liver tumors are urgently needed and that there is a ground for future advances in the field.
authors.affiliation: Institute of Experimental Genetics, School of Medical Sciences, National University of Rosario, Santa Fe 3100, (2000) Rosario, Argentina. matarpablo@hotmail.com
authors.forename: Pablo
authors.initials: P
authors.lastname: Matar
authors.forename: Laura
authors.initials: L
authors.lastname: Alaniz
authors.forename: Viviana
authors.initials: V
authors.lastname: Rozados
authors.forename: Jorge B
authors.initials: JB
authors.lastname: Aquino
authors.forename: Mariana
authors.initials: M
authors.lastname: Malvicini
authors.forename: Catalina
authors.initials: C
authors.lastname: Atorrasagasti
authors.forename: Manuel
authors.initials: M
authors.lastname: Gidekel
authors.forename: Marcelo
authors.initials: M
authors.lastname: Silva
authors.forename: O Graciela
authors.initials: OG
authors.lastname: Scharovsky
authors.forename: Guillermo
authors.initials: G
authors.lastname: Mazzolini
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D019496:Cancer Vaccines / Q000235:genetics / Q000276:immunology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D016207:Cytokines / Q000276:immunology / Q000627:therapeutic use; D003713:Dendritic Cells / Q000276:immunology; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007107:Immune System / Q000502:physiology; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D008099:Liver / Q000276:immunology / Q000473:pathology; D008113:Liver Neoplasms / Q000188:drug therapy / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D019496:Cancer Vaccines; D016207:Cytokines