TRIM-NHL proteins take on miRNA regulation.
The TRIM-NHL family of proteins is conserved among metazoans and has been shown to regulate cell proliferation and development. In this issue, Hammell et al. (2009) and Schwamborn et al. (2009) identify two members of this protein family, NHL-2 in worms and TRIM32 in mice, as positive regulators of microRNA function.
Loedige
Inga
I
Filipowicz
Witold
W
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000378:metabolism*; D017173:Caenorhabditis elegans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D051792:Basic Helix-Loop-Helix Proteins; D035683:MicroRNAs; D044767:Ubiquitin-Protein Ligases