title: Serum arylesterase activity is negatively correlated with inflammatory markers in patients with acute coronary syndromes.
abstract: OBJECTIVE
  To examined whether serum paraoxonase (PON1) and arylesterase (ARE) activities are correlated with inflammatory biomarkers (procalcitonin and high sensitivity C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS).
  
  
  METHODS
  This cross-sectional study was conducted at the Departments of Cardiology and Biochemistry, Uludag University School of Medicine, Bursa, Turkey, from April 2007 to December 2007. Seventy-eight consecutive patients with ACS and 39 healthy controls were investigated. Acute coronary syndrome patients were divided into 3 groups according to their clinical presentation: unstable angina pectoris (UAP) (Braunwald III-B, n=25), non-ST elevation myocardial infarction (NSTEMI) (n=18), and ST-elevation myocardial infarction (STEMI) (n=35). Serum PON1/ARE activities were measured spectrophotometrically. Levels of procalcitonin and hs-CRP were measured by immunoassay.
  
  
  RESULTS
  Paraoxonase/ARE activities were significantly lower in all patient groups compared to controls. No correlation between PON1/ARE activities and high-density-cholesterol levels was seen. Among ACS patients, serum ARE activity correlated inversely with baseline and 48-hour procalcitonin (r=-0.577, p=0.009, and r=-0.642, p=0.019) and hs-CRP levels (r=-0.614, p=0.03, and r=-0.719, p=0.044).
  
  
  CONCLUSIONS
  Serum ARE activity is reduced in ACS patients and inversely correlated with inflammatory markers.
authors.affiliation: Department of Cardiology, Uludag University School of Medicine, 16059, Gorukle, Bursa, Turkey. tunaysenturk@hotmail.com
authors.forename: Tunay
authors.initials: T
authors.lastname: Senturk
authors.forename: Emre
authors.initials: E
authors.lastname: Sarandol
authors.forename: Sumeyye
authors.initials: S
authors.lastname: Gullulu
authors.forename: Selda
authors.initials: S
authors.lastname: Erdinc
authors.forename: Osman
authors.initials: O
authors.lastname: Ozdabakoglu
authors.forename: Bulent
authors.initials: B
authors.lastname: Ozdemir
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Baran
authors.forename: Sinan
authors.initials: S
authors.lastname: Arslan
authors.forename: Ali
authors.initials: A
authors.lastname: Aydinlar
mesh_terms: D054058:Acute Coronary Syndrome / Q000201:enzymology*; D043303:Aryldialkylphosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002116:Calcitonin / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D002265:Carboxylic Ester Hydrolases / Q000097:blood*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000097:blood; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D002097:C-Reactive Protein; D002265:Carboxylic Ester Hydrolases; C019734:arylesterase; D043303:Aryldialkylphosphatase; D015740:Calcitonin Gene-Related Peptide