Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histological and immunohistochemical features of 3 cases.
This report describes the histological and immunohistochemical characteristics of 3 cases of nerve sheath myxoma (NSM)/neurothekeoma arising in the oral cavity. Histopathologically, 3 distinct variants were observed based on the amount of myxoid matrix: classic/hypocellular, cellular, and mixed types. Immunohistochemically, all types expressed strong immunoreactivity to S-100 protein (3/3), NSE (neuron-specific enolase) (3/3), and NGFR (nerve growth factor receptor) (3/3), whereas all cases were negative for SMA (smooth muscle actin) and FVIII. The number of Ki-67 positive cells was less than 5% in all lesions confirming the slow growing characteristics of NSM. The results suggest that NSMs of the oral cavity are true peripheral nerve sheath tumors and show close relationship to schwannoma.
Nishioka
Mai
M
Department of Diagnostic Oral Pathology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan. maimai.dlab@tmd.ac.jp
Aguirre
Rodelio L
RL
Ishikawa
Ayataka
A
Nagumo
Kiyoko
K
Wang
Li-Hong
LH
Okada
Norihiko
N
D002610:Cheek / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000473:pathology*; D018321:Neurothekeoma / Q000737:chemistry / Q000473:pathology*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D017475:Receptors, Nerve Growth Factor / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis
D017475:Receptors, Nerve Growth Factor; D009418:S100 Proteins; D010751:Phosphopyruvate Hydratase