title: Ocular side effects associated with imatinib mesylate and perifosine for gastrointestinal stromal tumor.
abstract: Imatinib mesylate and perifosine are two relatively new drugs that have improved outcomes for patients with gastrointestinal stromal tumors in recent years. The ocular side effects of these two drugs are discussed in this chapter. The most common ocular side effect associated with imatinib mesylate is periorbital edema. Perifosine has been associated with a ring-shaped perilimbal corneal ulceration that can be treated with topical steroids and topical antibiotics.
authors.affiliation: Section of Ophthalmology, Department of Head and Neck Surgery, The University of Texas M.D. Anderson Cancer Center, Unit 441, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
authors.forename: S Serdar
authors.initials: SS
authors.lastname: Dogan
authors.forename: Bita
authors.initials: B
authors.lastname: Esmaeli
mesh_terms: D001549:Benzamides; D005128:Eye Diseases / Q000139:chemically induced* / Q000188:drug therapy; D046152:Gastrointestinal Stromal Tumors / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D000068877:Imatinib Mesylate; D010767:Phosphorylcholine / Q000009:adverse effects / Q000031:analogs & derivatives*; D010879:Piperazines / Q000009:adverse effects*; D011743:Pyrimidines / Q000009:adverse effects*
chemical_list: D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D010767:Phosphorylcholine; C105905:perifosine; D000068877:Imatinib Mesylate