title: Increased risk of colonic neoplasia in patients with sporadic duodenal adenoma.
abstract: BACKGROUND
  Recent studies have shown an increased risk of colorectal neoplasia in patients with duodenal neoplasia. The aim of this retrospective case-control study was to confirm this risk.
  
  
  METHODS
  Rate of colorectal neoplasia in 29 patients with one or more duodenal adenomas were compared with controls matched for gender and age, but without duodenal adenomas (one case to two controls). Patients with neoplasia of the ampulla, familial adenomatous polyposis or other known hereditary conditions of the digestive tract were excluded. Indications for upper and lower gastrointestinal endoscopy in controls were abdominal pain or changes in bowel habits. Controls with anemia or digestive bleeding were not included. Neoplastic lesions found at colonoscopy were classified as adenomas, advanced adenomas (size > or =10 mm, villous component, high-grade dysplasia), cancers and advanced neoplasia (cancers and advanced adenomas). Comparison between groups was by Fisher's exact test or Student's t test. Odds-ratios (OR) and 95% confidence intervals were calculated, if the difference was significant.
  
  
  RESULTS
  Mean age of the 29 cases (seven women, 22 men) was 63.2 years and that of the 58 controls (14 women, 44 men) was 62.5 years. First-degree family history of colorectal cancer was present in four cases (13.8%) and eight controls (13.8%) (NS). Colonoscopy showed at least one adenoma in 15 cases (51.7%) and 11 controls (19%) (P=0.0027; OR 1.87, 1.0-3.49), advanced adenomas in four cases (13.8%) and three controls (5.2%) (NS), and colonic adenocarcinoma in three cases (10.3%) and no controls (0%) (P=0.03). Advanced neoplasia was present in seven cases (24.1%) and three controls (5.2%) (P=0.014; OR 2.86, 0.96-8.52). Results were not significantly modified after the exclusion of patients with a family history of colorectal cancer.
  
  
  CONCLUSIONS
  Although lacking in statistical power, these results confirm that patients with sporadic duodenal adenoma are at high risk of colonic adenoma and advanced neoplasia, warranting systematic colonoscopy.
authors.affiliation: Service d'hépatogastroentérologie, CHU Robert-Debré, avenue Général-Koenig, 51092 Reims cedex, France. stephlagarde@free.fr
authors.forename: S
authors.initials: S
authors.lastname: Lagarde
authors.forename: M
authors.initials: M
authors.lastname: Dauphin
authors.forename: C
authors.initials: C
authors.lastname: Delmas
authors.forename: F
authors.initials: F
authors.lastname: Vitry
authors.forename: O
authors.initials: O
authors.lastname: Bouché
authors.forename: G
authors.initials: G
authors.lastname: Thiéfin
authors.forename: M D
authors.initials: MD
authors.lastname: Diebold
authors.forename: G
authors.initials: G
authors.lastname: Cadiot
mesh_terms: D000236:Adenoma / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000453:epidemiology*; D004379:Duodenal Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D012189:Retrospective Studies; D012307:Risk Factors