title: Retinal blood flow detection in diabetic patients by Doppler Fourier domain optical coherence tomography.
abstract: We present human retinal blood flow investigation for diabetic patients using Doppler Fourier domain optical coherence tomography (FDOCT). The scanning pattern consisted of two concentric circles around the optic nerve head. The blood flow in one patient with diabetes and no retinpathy and another patient with treated proliferative diabetic retinopathy were measured. The patient without retinopathy showed a total blood flow value at the lower level of the normal range. The flow distribution between superior and inferior retina was balanced. The patient with diabetic retinopathy had a flow value lower than the normal people. Our study shows that Doppler FD-OCT can be used to evaluate the total retinal blood flow in patients with retinal diseases.
authors.affiliation: Center for Ophthalmic Optics & Lasers, Doheny Eye Institute and Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. yiminwan@usc.edu
authors.forename: Yimin
authors.initials: Y
authors.lastname: Wang
authors.forename: Amani
authors.initials: A
authors.lastname: Fawzi
authors.forename: Ou
authors.initials: O
authors.lastname: Tan
authors.forename: John
authors.initials: J
authors.lastname: Gil-Flamer
authors.forename: David
authors.initials: D
authors.lastname: Huang
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D004301:Doppler Effect; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008962:Models, Theoretical; D012039:Regional Blood Flow; D012171:Retinal Vessels / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000706:statistics & numerical data