In vitro study of the effectiveness of three commercial adsorbents for binding oleander toxins.
BACKGROUND
Oleander (Nerium oleander) poisoning is a common problem found in many parts of the world. The oleander toxicity is due to oleandrin and its aglycone metabolite oleandrigenin. Activated charcoal is a useful gastrointestinal decontamination agent that limits the absorption of ingested toxins. A relatively new clay product, Bio-Sponge, containing di-tri-octahedral smectite as the active ingredient, is also recommended for adsorbing bacterial toxins in the gastrointestinal tract. Bio-Sponge has been used to prevent gastrointestinal absorption of oleander toxins in livestock but the efficacy of activated charcoal and Bio-Sponge for adsorbing oleandrin and oleandrigenin has not yet been studied.


METHODS
An in vitro experiment to compare the efficacy of three commercially available adsorbents was performed. The adsorbents include Bio-Sponge, ToxiBan granules, and a generic grade activated charcoal.


RESULTS
ToxiBan granules have the highest adsorptive capacity, followed by the generic grade activated charcoal, and finally, Bio-Sponge.


CONCLUSIONS
Bio-Sponge did not adsorb oleandrin and oleandrigenin at concentrations that are expected to be present in the gastrointestinal tract of poisoned animals.


CONCLUSIONS
On the basis of this in vitro study, products containing activated charcoal are more effective for binding oleander toxins and providing gastrointestinal decontamination than products containing di-tri-octahedral smectite. However, the ability of these adsorbents to alter the clinical outcome in oleander-poisoned animals or humans is yet to be evaluated.
Tiwary
Asheesh K
AK
California Animal Health and Food Safety Laboratory System, School of Veterinary Medicine, University of California, West Health Sciences Drive, Davis, CA 95616, USA. aktiwary@ucdavis.edu
Poppenga
Robert H
RH
Puschner
Birgit
B
D000327:Adsorption; D000931:Antidotes / Q000737:chemistry* / Q000627:therapeutic use; D002298:Cardenolides / Q000737:chemistry / Q000506:poisoning; D002606:Charcoal / Q000737:chemistry* / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D030007:Nerium / Q000506:poisoning*; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry; D010939:Plant Poisoning / Q000188:drug therapy*; D017640:Silicates / Q000737:chemistry* / Q000627:therapeutic use
D000931:Antidotes; D002298:Cardenolides; D010936:Plant Extracts; D017640:Silicates; D002606:Charcoal; C033214:Smectite; C021065:oleandrin