The combination of IMT and stiffness parameter beta is highly associated with concurrent coronary artery disease in type 2 diabetes.
OBJECTIVE
The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter beta (ST) and IMT with concurrent CAD.


METHODS
IMT and ST were measured by ultrasound in 439 nondiabetic subjects as a control and 1528 type 2 diabetic subjects (T2DM) with or without CAD in a cross-sectional study.


RESULTS
Both IMT and ST significantly increased with age and group category, in the order of control, T2DM without CAD, and T2DM with CAD (p<0.001). The area under the curve on ROC analysis of ST for concurrent CAD was comparable to that for IMT. On multivariate logistic regression analysis, High IMT (>or=1.30 mm) and High stiffness (>or=20.0) had significant odds ratios for concurrent CAD (2.205, p<0.001 and 1.548, p<0.05, respectively). The group with High IMT and High Stiffness exhibited a stronger multivariate odds ratio (3.115, p=0.0001).


CONCLUSIONS
ST and IMT are associated with CAD and exhibited significant odds ratios for CAD. Our findings suggest that the combination of IMT and ST is a useful marker of atherosclerosis.
Lee
Eiko
E
Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka, Japan.
Emoto
Masanori
M
Teramura
Megumi
M
Tsuchikura
Shoko
S
Ueno
Hiroki
H
Shinohara
Kayo
K
Morioka
Tomoaki
T
Mori
Katsuhito
K
Koyama
Hidenori
H
Shoji
Tetsuo
T
Okuno
Yasuhisa
Y
Inaba
Masaaki
M
Nishizawa
Yoshiki
Y
D000367:Age Factors; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000209:etiology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D014463:Ultrasonography