title: Highly enantioselective iridium-catalyzed hydrogenation of 2-benzylquinolines and 2-functionalized and 2,3-disubstituted quinolines.
abstract: The enantioselective hydrogenation of 2-benzylquinolines and 2-functionalized and 2,3-disubstituted quinolines was developed by using the [Ir(COD)Cl](2)/bisphosphine/I(2) system with up to 96% ee. Moreover, mechanistic studies revealed the hydrogenation mechanism of quinoline involves a 1,4-hydride addition, isomerization, and 1,2-hydride addition, and the catalytic active species may be a Ir(III) complex with chloride and iodide.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Wang
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Wang
authors.forename: Duo-Sheng
authors.initials: DS
authors.lastname: Wang
authors.forename: Sheng-Mei
authors.initials: SM
authors.lastname: Lu
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
authors.forename: Yu-Xue
authors.initials: YX
authors.lastname: Li