Effect of irsogladine maleate on NSAID-induced reduction of gastric mucosal blood flow in anesthetized dogs.
OBJECTIVE
Although mucoprotective agents are commonly used against gastric and duodenal lesions in Japan, their availability as agents for non-steroidal anti-inflammatory drug (NSAID)-induced gastrointestinal damage has not been clarified. To investigate the effect of irsogladine maleate (IM) on gastric mucosal blood flow (GMBF) reduction induced by diclofenac sodium, a NSAID commonly used in Japan, by laser Doppler flowmetry (LDF) and ultrasonography (US) in canine stomach.


METHODS
GMBF was measured by LDF and contrast-enhanced US in 15 beagles. US was performed employing real-time harmonic imaging under low acoustic power after intravenous contrast injection using Definity (60 mg/kg). 60 min after insertion of a diclofenac sodium suppository (1.0 mg/kg) into the rectum, LDF and contrast-enhanced US were repeated. The examination was done in a crossover, single-blinded fashion.


RESULTS
The mean extent of the change in GMBF in the IM group and in the placebo group was +29.3 and -38%, respectively.


CONCLUSIONS
IM alleviates the reduction of GMBF induced by diclofenac sodium.
Sato
Motonori
M
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School, Okayama 701-0192, Japan.
Manabe
Noriaki
N
Hata
Jiro
J
Ishii
Manabu
M
Kamada
Tomoari
T
Kusunoki
Hiroaki
H
Shiotani
Akiko
A
Haruma
Ken
K
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D004285:Dogs; D005466:Fluorocarbons; D005753:Gastric Mucosa / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects; D017078:Laser-Doppler Flowmetry; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects*; D014227:Triazines / Q000494:pharmacology*; D014463:Ultrasonography
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D005466:Fluorocarbons; D014227:Triazines; C041836:irsogladine; C042852:perflutren