title: Idiopathic hypogonadotropic hypogonadism in selective human gonadotropin deficiency in adult man: a case report.
abstract: We report a rare case of idiopathic hypogonadotropic hypogonadism in an adult male (31-year-old), who underwent an endocrinological examination because of erectile dysfunction and suspected infertility. Laboratory data showed isolated gonadotropin deficiency. Magnetic resonance imaging (MRI) of the hypothalamic-pituitary unit showed no tumoral expansions. The patient was tested with gonadotropin releasing hormone (Gn-RH) (100 microg as an i.v. bolus injection). No significant LH and FSH responses were observed. Idiopathic hypogonadotropic hypogonadism is usually caused by hypothalamic lesions, however, since Gn-RH was unable to stimulate LH and FSH secretions, we supposed that our patient was affected by defective gonadotropin secretion at pituitary level.
authors.affiliation: Department of Internal Medicine and Biomedical Sciences, University of Parma, Parma, Italy. riccardo.volpi@unipr.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Volpi
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Ugolotti
authors.forename: Andrea
authors.initials: A
authors.lastname: Carbucicchio
authors.forename: Roberto
authors.initials: R
authors.lastname: Delsignore
mesh_terms: D000328:Adult; D000728:Androgens / Q000627:therapeutic use; D007172:Erectile Dysfunction / Q000209:etiology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D013739:Testosterone / Q000627:therapeutic use
chemical_list: D000728:Androgens; D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone