title: Actual management of ductal carcinoma in situ of the breast.
abstract: Ductal carcinoma in situ (DCIS) represents a premalignant, non-invasive intraductal carcinoma of the breast. About 30% of all mammographically detected breast cancers contain DCIS. Due to the increased use of mammography during the last 20 years the incidence of DCIS has dramatically risen. Histologically it represents a heterogenous group of potentially malignant lesions. The prognosis of DCIS is excellent, but the optimal management of the disease still remains controversial. This review summarizes the results of the latest randomized trials and retrospective analyses investigating the optimal therapeutic strategies in the treatment of DCIS. In addition, it presents a range of treatment options on the basis of the guidelines of the German gynecological oncology group (AGO) 2008.
authors.affiliation: Department of Gynecology and Obstetrics, University Hospital Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany. nmaass@ukaachen.de
authors.forename: Nicolai
authors.initials: N
authors.lastname: Maass
authors.forename: Ozkan
authors.initials: O
authors.lastname: Alkasi
authors.forename: Maret
authors.initials: M
authors.lastname: Bauer
authors.forename: Walter
authors.initials: W
authors.lastname: Jonat
authors.forename: R
authors.initials: R
authors.lastname: Souchon
authors.forename: Ivo
authors.initials: I
authors.lastname: Meinhold-Heerlein
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant