High-throughput experimentation platform: parallel microwave chemistry in HPLC/GC vials.
A high-throughput reaction platform for performing parallel microwave chemistry in sealed HPLC/GC vials is described. The system consists of a strongly microwave-absorbing silicon carbide plate with 20 cylindrical wells of appropriate dimensions to be fitted with standard HPLC/GC autosampler vials serving as reaction vessels. In combination with an aluminum sealing plate the setup can be used for microwave processing reaction volumes from 0.5-1.5 mL at a maximum temperature/pressure limit of 250 degrees C/20 bar. The parallel reaction platform displays excellent temperature and reaction homogeneity and has been used for high-throughput reaction optimization studies involving the parallel screening of catalyst, solvent and substrate reactivity for esterification reactions and metal-catalyzed dehydrative C-C couplings.
Damm
Markus
M
Christian Doppler Laboratory for Microwave Chemistry (CDLMC), Karl-Franzens-University Graz, Graz, Austria.
Kappe
C Oliver
CO
D017554:Carbon Compounds, Inorganic / Q000737:chemistry*; D002384:Catalysis; D002849:Chromatography, Gas / Q000295:instrumentation*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000295:instrumentation* / Q000379:methods*; D004867:Equipment Design / Q000295:instrumentation; D006358:Hot Temperature; D008872:Microwaves; D011312:Pressure; D017655:Silicon Compounds / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013379:Substrate Specificity
D017554:Carbon Compounds, Inorganic; D017655:Silicon Compounds; D012997:Solvents; C022088:silicon carbide