title: In vivo proton magnetic resonance spectroscopy of intraventricular tumours of the brain.
abstract: The aim of this study was to assess the usefulness of proton MR spectroscopy in the diagnosis of intraventricular tumours. Fifty-two intraventricular tumours pertaining to 16 different tumour types were derived from our database. All cases had single-voxel proton MR spectroscopy performed at TE at both 30 and 136 ms at 1.5 T. The Mann-Whitney U test was used to search for the most discriminative datapoints each tumour type. Characteristic trends were found for some groups: high Glx and Ala in meningiomas (p < 0.001 and p < 0.01, respectively), high mobile lipids in metastasis (p < 0.001), high Cho in PNET (p < 0.001), high mI + Gly in ependymoma (p < 0.001), high NAC (p < 0.01) in the absence of the normal brain parenchyma pattern in colloid cysts, and high mI/Gly and Ala in central neurocytoma. Proton MR spectroscopy provides additional metabolic information that could be useful in the diagnosis of intraventricular brain tumors.
authors.affiliation: Institut de Diagnòstic per la Imatge, Centre Bellvitge, Hospital Universitari de Bellvitge, Autovia de Castelldefels km 2.7, 08907, L'Hospitalet de Llobregat, Barcelona, Spain. cmajos@csub.scs.es
authors.forename: Carles
authors.initials: C
authors.lastname: Majós
authors.forename: Carles
authors.initials: C
authors.lastname: Aguilera
authors.forename: Mònica
authors.initials: M
authors.lastname: Cos
authors.forename: Angels
authors.initials: A
authors.lastname: Camins
authors.forename: Ana P
authors.initials: AP
authors.lastname: Candiota
authors.forename: Teresa
authors.initials: T
authors.lastname: Delgado-Goñi
authors.forename: Alex
authors.initials: A
authors.lastname: Samitier
authors.forename: Sara
authors.initials: S
authors.lastname: Castañer
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Sánchez
authors.forename: David
authors.initials: D
authors.lastname: Mato
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Acebes
authors.forename: Carles
authors.initials: C
authors.lastname: Arús
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001921:Brain / Q000378:metabolism*; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011522:Protons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D011522:Protons