Clinical investigation of asmofilcon a silicone hydrogel lenses.
OBJECTIVE
To investigate the clinical and subjective performance of asmofilcon A, a new third generation silicone hydrogel contact lens during 6-night extended wear (EW) over 6 months.


METHODS
A prospective, randomized, single-masked study was conducted. Sixty experienced daily wear soft contact lens wearers were randomly assigned to wear either asmofilcon A or senofilcon A contact lenses bilaterally for 6 months on an EW basis. Evaluations were conducted at contact lens delivery and after 1 week, 4 weeks, 3 and 6 months of EW.


RESULTS
Fifty subjects (83%) successfully completed the study. Two subjects experienced adverse events; one unilateral red eye with asmofilcon A and one asymptomatic infiltrate with senofilcon A. There were no significant differences in high or low contrast distance visual acuity between asmofilcon A and senofilcon A; however, low contrast distance visual acuity decreased significantly over time with both contact lens types (p < 0.05). The two lens types did not vary significantly with respect to any of the objective and subjective measures assessed (p > 0.05). Superior palpebral conjunctival injection showed a statistically significant increase over time with both lens types (p < 0.05). Both lens types were rated highly with respect to overall comfort, with subjects reporting 14 or 15 h of comfortable lens wearing time per day at each of the study visits (p > 0.05). Overall satisfaction ratings were also very high at all visits, with median scores of 95 (86 to 99) for asmofilcon A and 90 (85 to 96) for senofilcon A at 6 months (p > 0.05).


CONCLUSIONS
Over 6 months of EW, the asmofilcon A contact lens performed in a similar manner to senofilcon A with respect to visual acuity, ocular health, and contact lens performance measures. Longer-term EW studies are required to investigate the changes over time observed with both lens types.
Lakkis
Carol
C
Clinical Vision Research Australia, Victorian College of Optometry, Carlton, Australia. clakkis@vco.org.au
Vincent
Stephen
S
D000328:Adult; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects / Q000592:standards*; D015350:Contrast Sensitivity; D004215:Distance Perception; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D017060:Patient Satisfaction; D012828:Silicones; D016037:Single-Blind Method; D014792:Visual Acuity; D055815:Young Adult
D012828:Silicones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate