title: Three-dimensional ultrahigh resolution optical coherence tomography imaging of age-related macular degeneration.
abstract: Ultrahigh resolution optical coherence tomography (OCT) enhances the ability to visualize different intra retinal layers. In age-related macular degeneration (AMD), pathological changes in individual retinal layers, including photoreceptor inner and outer segments and retinal pigment epithelium, can be detected. OCT using spectral / Fourier domain detection enables high speed, volumetric imaging of the macula, which provides comprehensive three-dimensional tomographic and morphologic information. We present a case series of AMD patients, from mild drusen to more advanced geographic atrophy and exudative AMD. Patients were imaged with a research prototype, ultrahigh resolution spectral / Fourier domain OCT instrument with 3.5 microm axial image resolution operating at 25,000 axial scans per second. These cases provide representative volumetric datasets of well-documented AMD pathologies which could be used for the development of visualization and imaging processing methods and algorithms.
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: Yueli
authors.initials: Y
authors.lastname: Chen
authors.forename: Laurel N
authors.initials: LN
authors.lastname: Vuong
authors.forename: Jonathan
authors.initials: J
authors.lastname: Liu
authors.forename: Joseph
authors.initials: J
authors.lastname: Ho
authors.forename: Vivek J
authors.initials: VJ
authors.lastname: Srinivasan
authors.forename: Iwona
authors.initials: I
authors.lastname: Gorczynska
authors.forename: Andre J
authors.initials: AJ
authors.lastname: Witkin
authors.forename: Jay S
authors.initials: JS
authors.lastname: Duker
authors.forename: Joel
authors.initials: J
authors.lastname: Schuman
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008268:Macular Degeneration / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D015593:Retinal Drusen / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000473:pathology; D041623:Tomography, Optical Coherence / Q000379:methods* / Q000706:statistics & numerical data