title: Signal crosstalk between estrogen and peroxisome proliferator-activated receptor alpha on adiposity.
abstract: Peroxisome proliferator-activated receptor alpha and estrogen are believed to be involved in metabolic changes leading to obesity. To test this relationship, we divided female wildtype and PPAR alpha-deficient mice fed on a high fat diet into the following groups: mock-operated, ovariectomized (OVX), and E(2)-treated. The visceral white adipose tissue and plasma cholesterol levels were increased significantly in wild type OVX and decreased in the E(2)-treated group, but interestingly not in PPAR alpha-deficient mice. The mRNA levels of lipoprotein lipase in adipose tissue were also increased in only wild type OVX and decreased significantly in E(2)-treated mice. These novel results suggest the possibility of signaling crosstalk between PPAR alpha and E2, causing obesity in vivo.
authors.affiliation: Department of Toxicology, National Institute of Toxicological Research, Korea Food and Drug Administration, Seoul, Korea.
authors.forename: Bang Hyun
authors.initials: BH
authors.lastname: Kim
authors.forename: Young Suk
authors.initials: YS
authors.lastname: Won
authors.forename: Dae Yong
authors.initials: DY
authors.lastname: Kim
authors.forename: Bora
authors.initials: B
authors.lastname: Kim
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Mijung
authors.initials: M
authors.lastname: Yoon
authors.forename: Goo Taeg
authors.initials: GT
authors.lastname: Oh
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology / Q000378:metabolism*; D000818:Animals; D004041:Dietary Fats; D004967:Estrogens / Q000378:metabolism; D005260:Female; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009765:Obesity / Q000378:metabolism*; D010052:Ovariectomy; D047493:PPAR alpha / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D004041:Dietary Fats; D004967:Estrogens; D047493:PPAR alpha; D008071:Lipoprotein Lipase