title: Comparison of reflectivity maps and outer retinal topography in retinal disease by 3-D Fourier domain optical coherence tomography.
abstract: We demonstrate and compare two image processing methods for visualization and analysis of three-dimensional optical coherence tomography (OCT) data acquired in eyes with different retinal pathologies. A method of retinal layer segmentation based on a multiple intensity thresholding algorithm was implemented in order to generate simultaneously outer retinal topography maps and reflectivity maps. We compare the applicability of the two methods to the diagnosis of retinal diseases and their progression. The data presented in this contribution were acquired with a high speed (25,000 A-scans/s), high resolution (4.5 microm) spectral OCT prototype instrument operating in the ophthalmology clinic.
authors.affiliation: Institute of Physics, Nicolaus Copernicus University, Grudziadzka 5/7, PL-87-100 Toruń, Poland. max@fizyka.umk.pl
authors.forename: Maciej
authors.initials: M
authors.lastname: Wojtkowski
authors.forename: Bartosz L
authors.initials: BL
authors.lastname: Sikorski
authors.forename: Iwona
authors.initials: I
authors.lastname: Gorczynska
authors.forename: Michalina
authors.initials: M
authors.lastname: Gora
authors.forename: Maciej
authors.initials: M
authors.lastname: Szkulmowski
authors.forename: Danuta
authors.initials: D
authors.lastname: Bukowska
authors.forename: Jakub
authors.initials: J
authors.lastname: Kaluzny
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
authors.forename: Andrzej
authors.initials: A
authors.lastname: Kowalczyk
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D020256:Choroidal Neovascularization / Q000473:pathology; D016208:Databases, Factual; D004867:Equipment Design; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D021621:Imaging, Three-Dimensional; D007368:Interferometry; D008268:Macular Degeneration / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012160:Retina / Q000033:anatomy & histology / Q000473:pathology*; D012163:Retinal Detachment / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis / Q000473:pathology*; D015593:Retinal Drusen / Q000473:pathology; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D055815:Young Adult