Pharmacokinetics of intracameral voriconazole injection.
Elimination of voriconazole after intracameral injection exhibited an exponential decay with a half-life of 22 min. Voriconazole levels in the vitreous humor were below the detectable limit. The aqueous concentrations achieved with a 25-microg dose during the first 2 h were greater than the previously reported MICs of organisms most involved in fungal endophthalmitis. A rapid decline in intracameral concentration suggests that frequent supplementation of intracameral voriconazole may be required in clinical settings.
Shen
Ying-Cheng
YC
Department of Ophthalmology, Taichung Veterans General Hospital, No. 160, Section 3, Taichung Harbor Road, Taichung, Taiwan, Republic of China.
Wang
Mei-Yen
MY
Wang
Chun-Yuan
CY
Tsai
Tsun-Chung
TC
Tsai
Hin-Yeung
HY
Lee
Hsin-Nung
HN
Wei
Li-Chen
LC
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001082:Aqueous Humor / Q000378:metabolism*; D006207:Half-Life; D007267:Injections; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D014230:Triazoles / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014822:Vitreous Body / Q000378:metabolism*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole