Synthesis and anticonvulsant activity of amino acid-derived sulfamides.
Sulfamides are promising functions for the design of new antiepileptic drugs ( Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614 ). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
Gavernet
Luciana
L
Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, 47 and 115, La Plata B1900BJW, Argentina. lgavernet@biol.unlp.edu.ar
Elvira
Juan E
JE
Samaja
Gisela A
GA
Pastore
Valentina
V
Cravero
Mariana Sella
MS
Enrique
Andrea
A
Estiu
Guillermina
G
Bruno-Blanch
Luis E
LE
D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D000577:Amides; D000927:Anticonvulsants