title: Antibiotic resistance and penicillin tolerance in ano-vaginal group B streptococci.
abstract: OBJECTIVE
  We sought to determine the prevalence of group B streptococcus (GBS) colonisation and to characterise antibiotic resistance patterns.
  
  
  METHODS
  Vaginal and ano-rectal cultures were evaluated for GBS colonisation, and antibiotic susceptibility profiles were determined to 15 antibiotics according to the guidelines of the National Committee for Clinical Laboratory Standards.
  
  
  RESULTS
  Our GBS prevalence was 30%. All isolates were sensitive to amoxicillin/clavulanic acid, ampicillin, ampicillin/sulbactam, cefotaxime, ceftriaxone, cefuroxime-sodium, imipenem, linezolid, penicillin G and vancomycin. Thirty-two percent of the isolates were resistant to azithromycin, 21% to clindamycin, 25% to erythromycin and 23% to tetracycline.
  
  
  CONCLUSIONS
  The relatively high rates of resistance to four of the 15 antibiotics tested confirm that for women allergic to penicillin and colonised with GBS, antibiotic sensitivities should be determined. We noticed increasing resistance to clindamycin over a 7-year period. Ongoing surveillance of local antibiotic resistance patterns at the institutional level is important in determining optimal prophylaxis as resistance patterns differ between institutions and are increasing.
authors.affiliation: Department of OB/Gyn, Bridgeport Hospital, Yale New Haven Health System, Bridgeport, Connecticut 06610, USA. brittapanda@web.de
authors.forename: Britta
authors.initials: B
authors.lastname: Panda
authors.forename: Igor
authors.initials: I
authors.lastname: Iruretagoyena
authors.forename: Robert
authors.initials: R
authors.lastname: Stiller
authors.forename: Alexander
authors.initials: A
authors.lastname: Panda
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D044383:Black People; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D010400:Penicillin G / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D011446:Prospective Studies; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy*; D013292:Streptococcus agalactiae / Q000302:isolation & purification; D014621:Vagina / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D010400:Penicillin G