Fetal borderline cerebral ventriculomegaly: clinical significance and management.
OBJECTIVE
The aim of this study was to evaluate the clinical significance and the management of fetal borderline lateral cerebral ventriculomegaly.


METHODS
Fetuses with a sonographic diagnosis of lateral cerebral ventriculomegaly isolated or associated to other fetal malformations were followed monthly and a review of the English-language literature was made.


RESULTS
Of 86 fetuses analyzed, 30 suffered from hydrocephaly (monolateral, bilateral), 56 showed also several other malformations . Chromosomal aberrations is possible also in case of isolated hydrocephaly. Neurological sequelae, mostly a mild to moderate delay in cognitive and/or motor development, is present in 10% of the cases.


CONCLUSIONS
In most cases, isolated borderline lateral cerebral ventriculomegaly has no consequence. However, the risk of cerebral maldevelopment, delayed neurological development and, possibly, chromosomal aberrations is increased. The optimum management of these cases remains uncertain.
Simioli
S
S
Ostetrics and Ginecology Emergency Unit, Department of Ostetrics, Ginecology and Reproduction Physiopathology, University Federico II, Naples, Italy. martinel@unina.it
Napolitano
R
R
Quaglia
F
F
Mazzarelli
L L
LL
Agangi
A
A
Milanes
G Mallia
GM
Tessitore
G
G
Iannaccone
A
A
Maruotti
G M
GM
Martinelli
P
P
D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging*; D000029:Abortion, Legal; D000328:Adult; D002552:Cerebral Ventricles / Q000002:abnormalities; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging*; D020547:Lateral Ventricles / Q000002:abnormalities*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011296:Prenatal Diagnosis; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D016216:Ultrasonography, Prenatal