Image integration-guided catheter ablation of atrial fibrillation: a prospective randomized study.
BACKGROUND
Several studies have provided details of left atrial anatomy by means of the image integration techniques, particularly focusing on the atypical patterns of the pulmonary veins.


OBJECTIVE
To compare, in a prospective, randomized fashion, the conventional method of pulmonary vein disconnection and the image integration-guided approach.


METHODS
Two hundred and ninety consecutive patients (290 patients, mean age 55 +/- 11 years) with drug-refractory paroxysmal or persistent atrial fibrillation were enrolled in the study and were divided into two treatment groups: group 1 (145 patients) undergoing an imaging integration-guided (CartoMerge TM) ablation; group 2 (145 patients) treated by a conventional radiofrequency catheter ablation procedure. The arrhythmia was refractory to at least two antiarrhythmic drugs (IC, amiodarone).


RESULTS
Electrical disconnection of all identified pulmonary veins was obtained in all patients of both groups. Bidirectional block of the cavotricuspid isthmus was achieved in 34 group 1 patients and in 40 group 2 patients. Left mitral isthmus ablation was attempted in 52 group 1 patients and in 56 group 2 patients. At a mean follow-up of 14 +/- 12 months, the atrial fibrillation-free survival rate was significantly higher in group 1 patients compared with group 2 patients (88% vs 69%, P = 0.017). The analysis for the subset of patients with previously ineffective ablation (98 patients: 52 group 1 patients and 46 group 2 patients) showed a significantly lower recurrence rate in group 1 versus group 2 (19% vs 48%, P < 0.01).


CONCLUSIONS
Our data indicate a superior efficacy of the image-integration guided catheter ablation of atrial fibrillation over the long term.
Della Bella
Paolo
P
Centro Cardiologico Monzino, Institute of Cardiology of the University of Milan, Milan, Italy. paolo.dellabella@ccfm.it
Fassini
Gaetano
G
Cireddu
Manuela
M
Riva
Stefania
S
Carbucicchio
Corrado
C
Giraldi
Francesco
F
Maccabelli
Giuseppe
G
Trevisi
Nicola
N
Moltrasio
Massimo
M
Pepi
Mauro
M
Galli
Claudia A
CA
Andreini
Daniele
D
Ballerini
Giovanni
G
Pontone
Gianluca
G
D001281:Atrial Fibrillation / Q000000981:diagnostic imaging* / Q000601:surgery*; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D017115:Catheter Ablation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D025321:Surgery, Computer-Assisted / Q000379:methods*; D018511:Systems Integration; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome