Time-dependent oxidative stress responses of crucian carp (Carassius auratus) to intraperitoneal injection of extracted microcystins.
This study was conducted to investigate time-dependent changes in oxidative enzymes in liver of crucian carp after intraperitoneally injection with extracted microcystins 600 and 150 microg kg(-1) body weight. The results showed that activities of antioxidant enzymes, including superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase generally exhibited a rapid increase in early phase (1-3 h post injection), but gradually decreased afterwards (12-48 h) compared with the control, with an evident time-dependent effect. These zigzag changes over time contributed a better understanding on oxidative stress caused by microcystins in fish.
Zhang
X
X
Fisheries College of Huazhong Agricultural University, 430070, Wuhan, People's Republic of China. xuezhen@mail.hzau.edu.cn
Xie
P
P
Li
D
D
Tang
R
R
Lei
H
H
Zhao
Y
Y
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D029941:Fish Proteins / Q000378:metabolism; D006054:Goldfish / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D052998:Microcystins / Q000008:administration & dosage / Q000302:isolation & purification / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D013997:Time Factors
D000975:Antioxidants; D029941:Fish Proteins; D052998:Microcystins