title: On the path to seeking novel radiosensitizers.
abstract: Radiation therapy is a highly effective cancer treatment modality, and extensive investigations have been undertaken over the years to augment its efficacy in the clinic. This review summarizes the current understanding of the biologic bases underpinning many of the clinically used radiosensitizers. In addition, this review illustrates how the advent of innovative, high-throughput technologies with integration of different disciplines could be harnessed for an expeditious discovery process for novel radiosensitizers, providing an exciting future for such pursuits in radiation biology and oncology.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada.
authors.forename: David
authors.initials: D
authors.lastname: Katz
authors.forename: Emma
authors.initials: E
authors.lastname: Ito
authors.forename: Fei-Fei
authors.initials: FF
authors.lastname: Liu
mesh_terms: D015687:Cell Hypoxia / Q000502:physiology; D003131:Combined Modality Therapy / Q000379:methods; D004249:DNA Damage / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000502:physiology; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011836:Radiation Tolerance / Q000502:physiology; D011838:Radiation-Sensitizing Agents / Q000145:classification / Q000378:metabolism / Q000627:therapeutic use*
chemical_list: D051793:Hypoxia-Inducible Factor 1; D011838:Radiation-Sensitizing Agents