Poly(styrene-alt-maleic anhydride) derivatives as potent anti-HIV microbicide candidates.
Topical microbicides offer women the opportunity to protect themselves from sexual HIV transmission under their own control. A series of poly[styrene-alt-(maleic anhydride)] derivatives were prepared by amidation or hydrolysis of the anhydride moiety. The derivatives were shown to be of low cell toxicity and effectively inhibited HIV-1 infections in an in vitro cellular model. Poly[styrene-alt-(maleic acid, sodium salt)] was the most potent inhibitor, being 100-fold more potent than dextran sulfate suggesting its potential application as a new class of polyanionic microbicides.
Fang
Weijun
W
Department of Chemistry, College of Chemistry and Chemical Engineering, and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, PR China.
Cai
Yijun
Y
Chen
Xiaoping
X
Su
Rongmin
R
Chen
Tong
T
Xia
Ningshao
N
Li
Lei
L
Yang
Quanli
Q
Han
Jiahuai
J
Han
Shoufa
S
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D000891:Anti-Infective Agents, Local / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002460:Cell Line; D015658:HIV Infections / Q000517:prevention & control; D006367:HeLa Cells; D006801:Humans; D008298:Maleates / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011137:Polystyrenes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D019380:Anti-HIV Agents; D000891:Anti-Infective Agents, Local; D008298:Maleates; D011137:Polystyrenes; C520889:poly(styrene-alt-maleic anhydride)