Oxidation of tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes: evidence for their oxidative decarboxylation and molecular origin of their specific ability to react with O2*-.
Tris-(p-carboxyltetrathiaaryl)methyl radical EPR probes are very efficiently oxidized by superoxide and alkylperoxyl radicals with selective formation of quinone-methide products; this should explain the previously reported specific measurement of O2*- using these EPR probes.
Decroos
Christophe
C
Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, Université Paris Descartes, CNRS UMR 8601, 45 rue des Saints Pères, 75006 Paris, France.
Li
Yun
Y
Bertho
Gildas
G
Frapart
Yves
Y
Mansuy
Daniel
D
Boucher
Jean-Luc
JL
D002264:Carboxylic Acids / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D045563:Indolequinones / Q000737:chemistry; D015335:Molecular Probes / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*
D002264:Carboxylic Acids; D005609:Free Radicals; D006575:Heterocyclic Compounds, 3-Ring; D045563:Indolequinones; D015335:Molecular Probes; C068040:quinone methide; D010100:Oxygen