Association of HLA-A in autoimmune myasthenia gravis with thymoma.
We investigated an association of the HLA-A locus in 78 French Caucasian patients with autoimmune myasthenia gravis (MG) and thymic epithelial tumours. The largest effect was a protection associated with HLA-A02 in MG patients with a B2 type thymoma (OR=0.323, 95% CI: 0.113-0.756, P=0.00041). The frequency of HLA-A25 was also increased in the whole group of patients (OR=3.62, 95% CI: 1.62-7.08, P=0.0041). Our findings emphasise the interest of the histological classification in the genetic study of thymomas.
Vandiedonck
Claire
C
Inserm U and Université Paris Descartes, Institut Cochin, Department of Immunology, France.
Raffoux
Colette
C
Eymard
Bruno
B
Tranchant
Christine
C
Dulmet
Elisabeth
E
Krumeich
Sophie
S
Gajdos
Philippe
P
Garchon
Henri-Jean
HJ
D000328:Adult; D001323:Autoantibodies / Q000032:analysis / Q000097:blood; D004252:DNA Mutational Analysis; D005260:Female; D005602:France; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005828:Genetics, Population; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D006579:Heterozygote; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000208:ethnology / Q000235:genetics* / Q000276:immunology*; D013945:Thymoma / Q000235:genetics* / Q000276:immunology* / Q000473:pathology; D013950:Thymus Gland / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D044465:White People
D001323:Autoantibodies; D005819:Genetic Markers; D015234:HLA-A Antigens; C037019:HLA-A*25 antigen