Targeting ketone drugs towards transport by the intestinal peptide transporter, PepT1.
Thiodipeptide prodrugs of the ketone nabumetone are shown to have affinity for, and be transported by, PepT1 in vitro.
Foley
David
D
School of Chemistry, University of Manchester, Manchester, M13 9PL, UK. david.foley@postgrad.manchester.ac.uk
Bailey
Patrick
P
Pieri
Myrtani
M
Meredith
David
D
D001692:Biological Transport; D002074:Butanones / Q000737:chemistry*; D004151:Dipeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007421:Intestine, Small / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D000077430:Nabumetone; D000074011:Peptide Transporter 1; D011355:Prodrugs / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism*; D027981:Symporters / Q000737:chemistry / Q000378:metabolism*
D002074:Butanones; D004151:Dipeptides; D007659:Ketones; D000074011:Peptide Transporter 1; D011355:Prodrugs; C082186:SLC15A1 protein, human; D013438:Sulfhydryl Compounds; D027981:Symporters; D000077430:Nabumetone