title: [Comparison on mitochondrial ATP6, ATP8 and Cyt b genes between Chinese Tibetans in three different zones: detecting the signature of natural selection on mitochondrial genome].
abstract: Mitochondrial DNA (mtDNA) differs from nuclear genome in many aspects such as lack of recombination, thus the investigation of mtDNA plays an essential role in human evolutionary history. We compared different sequences (approximately 2 kb) of ATP6, ATP8 and Cyt b genes in mtDNA among Tibetans in three different zones and found that the whole mtDNA sequences of the three genes, ATP6 and ATP 8 genes deviate gradually from neutral model with the increase of altitudes, yet no differences were observed. Also we found that the effect of purifying selection on Cyt b gene was elevated with the decrease of altitudes. Meanwhile, there was a possibility for the adaptive selection in ATP6 gene, which had an enhanced trend with the increase of altitudes. Thus, the geographic environment is the main determinant for selection, namely, different geographic environment has direct effect on selection.
authors.affiliation: Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences (CAMS) & Institute of Medical Biology, Peking Union Medical College (PUMC), Kunming 650118, China. minglianggu@imbcams.com.cn
authors.forename: Ming-Liang
authors.initials: ML
authors.lastname: Gu
authors.forename: Ye-Jun
authors.initials: YJ
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Yong-Biao
authors.initials: YB
authors.lastname: Zhang
authors.forename: Jia-You
authors.initials: JY
authors.lastname: Chu
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics*; D044466:Asian People; D004272:DNA, Mitochondrial / Q000032:analysis*; D019143:Evolution, Molecular; D020869:Gene Expression Profiling; D005787:Gene Frequency; D054629:Genome, Mitochondrial; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D025261:Mitochondrial Proton-Translocating ATPases / Q000235:genetics*; D008969:Molecular Sequence Data; D012343:RNA, Transfer; D012641:Selection, Genetic; D017422:Sequence Analysis, DNA; D018609:Tibet / Q000208:ethnology
chemical_list: D004272:DNA, Mitochondrial; C501005:MT-ATP6 protein, human; D012343:RNA, Transfer; D000251:Adenosine Triphosphatases; C111067:ATP8B1 protein, human; D025261:Mitochondrial Proton-Translocating ATPases