Asymmetric dihydroxylation of aryl olefins by sequential enantioselective epoxidation and regioselective hydrolysis with tandem biocatalysts.
Chiral aryl vicinal diols were obtained in high ee and yield by asymmetric dihydroxylation of aryl olefins with tandem biocatalysts: one contains an enantioselective styrene monooxygenase, and the other contains a regioselective epoxide hydrolase.
Xu
Yi
Y
Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576.
Jia
Xin
X
Panke
Sven
S
Li
Zhi
Z
D000475:Alkenes / Q000737:chemistry*; D055162:Biocatalysis; D004851:Epoxide Hydrolases / Q000737:chemistry*; D004925:Escherichia / Q000201:enzymology; D006900:Hydroxylation; D015394:Molecular Structure; D010105:Oxygenases / Q000737:chemistry*; D020578:Sphingomonas / Q000201:enzymology; D013237:Stereoisomerism
D000475:Alkenes; D010105:Oxygenases; C026721:styrene monooxygenase; D004851:Epoxide Hydrolases