[Separation of enantiomers of three chiral drugs by capillary electrophoresis based on achiral ionic liquid].
Using an achiral ionic liquid, 1-butyl-3-methylimidazolium chlorine ([ BMIM] Cl), as an additive and beta-cyclodextrin (beta-CD) as a chiral selector, the enantiomers of chlorpheniramine, the precursor of chloramphenicol and of loxacin were separated by capillary zone electrophoresis. This work was directed to the study of the association of [BMIM] Cl to the chiral selector beta-CD and the possible effects of [BMIM] Cl on chiral separation. Simultaneously, the separation performances were studied when only containing beta-CD in the buffer. The results showed that there are synergistic effects of [BMIM] Cl as an additive for the enantiomeric separations. [BMIM] Cl can not only remarkably increase the separation selectivity and resolution of the enantiomers, but also effectively restrain the adsorption of the sample molecules and improve the peak shape. [BMIM] Cl as an additive of chiral separation can provide a new method for the separation of chiral drugs which are hard separable under common electrophoresis conditions.
Xia
Chen
C
College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400030, China. xiachen3722496@yahoo.com.cn
Chen
Zhitao
Z
Xia
Zhining
Z
D000327:Adsorption; D002744:Chlorpheniramine / Q000737:chemistry / Q000302:isolation & purification; D019075:Electrophoresis, Capillary / Q000379:methods*; D007093:Imidazoles / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D015242:Ofloxacin / Q000737:chemistry / Q000302:isolation & purification; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000302:isolation & purification*; D011355:Prodrugs / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism; D047392:beta-Cyclodextrins / Q000737:chemistry
D007093:Imidazoles; D052578:Ionic Liquids; D004364:Pharmaceutical Preparations; D011355:Prodrugs; D047392:beta-Cyclodextrins; D002744:Chlorpheniramine; C502841:1-butyl-3-methylimidazolium chloride; D015242:Ofloxacin; C031215:betadex