Tickets for p53 journey among organelles.
A broad range of stressors - intrinsic and extrinsic to the cell - stabilize and activate p53, affecting it by a series of post-translational modifications such as phosphorylation, acetylation, ubiquitination, methylation and sumoylation. p53 is able to integrate each kind of post-translational modification and to adequately respond by inducing cell cycle arrest, senescence or apoptosis. p53 controls the cell fate at the level of different compartments, and its trafficking among organelles is modulated by different types of post-translational modifications. Thus, miss-location or sequestration of p53 within a compartment might obstruct its function as tumor suppressor leading to cell immortalization and tumorigenesis. The aim of this contribution is to give a unified overview of several reports in the literature, concerning the post-translational modifications endured by p53 which regulate its cellular trafficking and distribution at different organelles.
Ferecatu
Ioana
I
Laboratoire de Genetique et Biologie Cellulaire, CNRS UMR 8159, Universite de Versailles Saint-Quentin-en-Yvelines, 45 avenue des Etats-Unis, 78035 Versailles cedex, France.
Rincheval
Vincent
V
Mignotte
Bernard
B
Vayssiere
Jean-Luc
JL
D006801:Humans; D015388:Organelles / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
D016159:Tumor Suppressor Protein p53