title: 5HTT polymorphisms are associated with job stress in Japanese workers.
abstract: Recently, the number of workers who suffer from job stress was increasing in Japan because of a prolonged recession, increasing number of elderly workers, and structural reorganization of companies. On the other hand, polymorphism associated with depression or alcoholism was detected. Relationship between job stress and these polymorphisms were investigated. Brief job stress questionnaire was assessed for 243 employees who worked at a manufacturing company and a local hospital in Japan (mean age 40.8 years). Alcohol consumption and smoking habit were assessed as lifestyle factors. DNA samples were prepared to detect polymorphisms of 5HTT, aldehyde dehydrogenase 2 (ALDH2), D2 dopamine receptor (DRD2), and cytochrome p450 2A6 (CYP2A6) genes. The level of depressed mood by job stress was significantly higher among carriers of two short alleles of the 5HTT regulatory region compared with carriers of one or two long alleles (Mann-Whitney U, p<0.05). In a logistic regression analysis, the s/s allele of the 5HTT had a tendency to be a risk of depressed mood. When subjects had high supervisor's support, depressed mood was significantly lower irrespective of 5HTT polymorphism. Job stress may elicit biological responses that contribute to depressed mood in relation to 5HTT polymorphism.
authors.affiliation: Department of Public Health, Kawasaki Medical School, 577 Matsushima, Kurashiki 701-0192, Japan. katsu@med.kawasaki-m.ac.jp
authors.forename: Hironobu
authors.initials: H
authors.lastname: Katsuyama
authors.forename: Masafumi
authors.initials: M
authors.lastname: Tomita
authors.forename: Toshiko
authors.initials: T
authors.lastname: Okuyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Hidaka
authors.forename: Yoko
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Yoshie
authors.initials: Y
authors.lastname: Tamechika
authors.forename: Shigeko
authors.initials: S
authors.lastname: Fushimi
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Saijoh
mesh_terms: D000328:Adult; D000444:Aldehyde Dehydrogenase / Q000235:genetics; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000483:Alleles; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D065637:Cytochrome P-450 CYP2A6; D003863:Depression / Q000235:genetics; D004651:Employment; D005260:Female; D006579:Heterozygote; D006801:Humans; D007564:Japan; D008297:Male; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013315:Stress, Psychological / Q000235:genetics*; D011795:Surveys and Questionnaires
chemical_list: D017448:Receptors, Dopamine D2; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D001189:Aryl Hydrocarbon Hydroxylases; C585710:CYP2A6 protein, human; D065637:Cytochrome P-450 CYP2A6; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial