Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features.
We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F=8.0, p=.031) and QPDTPHASE (chi-square=12.54, p=.028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square=15.51, p=.030), but not QTDT (chi-square=2.07, p=.560).
Bergen
Sarah E
SE
Virginia Commonwealth University, Department of Human and Molecular Genetics, Richmond, Virginia 23219, USA. sbergen@gmail.com
Fanous
Ayman H
AH
Walsh
Dermot
D
O'Neill
F Anthony
FA
Kendler
Kenneth S
KS
D003702:Delusions / Q000235:genetics; D005190:Family; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006212:Hallucinations / Q000235:genetics; D006801:Humans; D026901:Membrane Transport Proteins / Q000235:genetics; D008995:Monoamine Oxidase / Q000235:genetics*; D010651:Phenylalanine Hydroxylase / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011618:Psychotic Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D018079:Receptors, GABA / Q000235:genetics; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
D005819:Genetic Markers; D026901:Membrane Transport Proteins; D018079:Receptors, GABA; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D010651:Phenylalanine Hydroxylase; D008995:Monoamine Oxidase