title: New therapeutic approaches for advanced gastrointestinal stromal tumors.
abstract: The management of advanced gastrointestinal stromal tumor is increasingly complex because of imatinib refractory disease. Primary resistance to imatinib is uncommon, and most patients progress after development of additional genetic changes. This article reviews management strategies including surgical approaches, local modalities for progressive liver metastases, as well as novel therapeutic agents.
authors.affiliation: Department of Medical Oncology, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA.
authors.forename: Neeta
authors.initials: N
authors.lastname: Somaiah
authors.forename: Margaret
authors.initials: M
authors.lastname: von Mehren
mesh_terms: D019008:Drug Resistance, Neoplasm; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy; D016879:Salvage Therapy / Q000379:methods*