Screening of dipeptides having central functions for excitation and sedation.
The naturally-occurring dipeptide carnosine (beta-alanyl-L-histidine) and the tripeptide glutathione (L-gammaglutamyl-L-cysteinylglycine) are found extensively in animal tissues such as brain and skeletal muscle. Central functions for excitation and sedation of them and their derivatives were screened.
Yamane
H
H
Laboratory of Advanced Animal and Marine Bioresources, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
Denbow
D M
DM
Furuse
M
M
D000818:Animals; D002336:Carnosine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology* / Q000502:physiology; D004353:Drug Evaluation, Preclinical; D005978:Glutathione / Q000031:analogs & derivatives / Q000494:pharmacology / Q000502:physiology; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008954:Models, Biological; D015394:Molecular Structure
D000697:Central Nervous System Stimulants; D004151:Dipeptides; D006993:Hypnotics and Sedatives; D002336:Carnosine; D005978:Glutathione