Short report: Development of post-kala-azar dermal leishmaniasis (PKDL) in miltefosine-treated visceral leishmaniasis.
We report two cases of post-kala-azar dermal leishmaniasis (PKDL), which had subsequently developed after successful treatment of visceral leishmaniasis with miltefosine. Both patients had maculo-nodular lesions all over the body, and they were diagnosed as PKDL by parasitologic examination for Leishmania donovani bodies in a skin snip of lesions. Patients were put on amphotericin B and responded very well for nodular lesions with one course of treatment. However, longer duration of the treatment is needed for total clearance of macular lesions from body surface in PKDL cases. This is the first case report of PKDL in India, which developed after successful treatment of visceral leishmaniasis with miltefosine.
Das
Vidya Nand Rabi
VN
Division of Clinical Medicine, Rajendra Memorial Research Institute of Medical Sciences (Indian Council of Medical Research), Agamkuan, Patna, Bihar, India. drkrishnapandey@yahoo.com
Pandey
Krishna
K
Verma
Neena
N
Lal
Chandra Shekhar
CS
Bimal
Sanjeev
S
Topno
Roshan Kamal
RK
Singh
Dharmendra
D
Siddiqui
Niyamat Ali
NA
Verma
Rakesh Bihari
RB
Das
Pradeep
P
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D003872:Dermatitis / Q000150:complications; D006801:Humans; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000209:etiology; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010767:Phosphorylcholine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000981:Antiprotozoal Agents; D010767:Phosphorylcholine; C039128:miltefosine; D000666:Amphotericin B