title: Serum deoxyribonuclease I can be used as a useful marker for diagnosis of death due to ischemic heart disease.
abstract: We recently reported abrupt elevation of serum deoxyribonuclease I (DNase I) activity in the early stage of acute myocardial infarction (AMI). The aim of this study was to evaluate whether serum DNase I could be used as a marker for detection of myocardial ischemia that accompanies AMI. In consecutive patients with stable angina pectoris undergoing elective percutaneous coronary intervention (PCI) or the vasospastic angina pectoris (VSAP) provocation test, together with patients undergoing coronary angiography (CAG), serum samples were tested for DNase I activity. Serum DNase I activity was found to rise significantly within 3h after PCI, and also after the provocation test in the VSAP-positive group. In all of the CAG and VSAP-negative patients, DNase I activity levels remained unchanged. Transient myocardial ischemia resulting from PCI or VSAP induces a significant elevation of serum DNase I activity, indicating that serum DNase I may be applicable as a novel and specific marker for detection of myocardial ischemia. Similarly, it is suggested that serum DNase I could be potentially useful as a biochemical marker for diagnosis of death due to ischemic heart disease.
authors.affiliation: Division of Medical Genetics and Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910-1193, Japan. tyasuda@u-fukui.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yasuda
authors.forename: Reiko
authors.initials: R
authors.lastname: Iida
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kawai
authors.forename: Tamiko
authors.initials: T
authors.lastname: Nakajima
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Kominato
authors.forename: Junko
authors.initials: J
authors.lastname: Fujihara
authors.forename: Haruo
authors.initials: H
authors.lastname: Takeshita
mesh_terms: D000787:Angina Pectoris / Q000097:blood; D015906:Angioplasty, Balloon, Coronary; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003850:Deoxyribonuclease I / Q000097:blood*; D004874:Ergonovine; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D008297:Male; D017202:Myocardial Ischemia / Q000097:blood / Q000175:diagnosis*; D014662:Vasoconstrictor Agents
chemical_list: D015415:Biomarkers; D014662:Vasoconstrictor Agents; D003850:Deoxyribonuclease I; D004874:Ergonovine