Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia.
Matrix metalloproteinase-9 (MMP-9) plays a role in many pathological conditions (e.g. cancer and heart disease). Recently, MMP-9 has been implicated in the activity of the prefrontal cortex and we therefore hypothesized that the MMP-9 gene may be associated with schizophrenia. We genotyped the functional -1562C/T polymorphism in a group of 442 schizophrenia patients and in 558 healthy control subjects. A significant preponderance of C/C genotype and C allele was found in the schizophrenia subjects compared to healthy controls. The results may provide the first evidence for involvement of the MMP-9 gene in the pathogenesis of schizophrenia and could also contribute to explaining a genetic connection between schizophrenia and some somatic illnesses.
Rybakowski
Janusz K
JK
Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland. rybakows@wlkp.top.pl
Skibinska
Maria
M
Kapelski
Pawel
P
Kaczmarek
Leszek
L
Hauser
Joanna
J
D000328:Adult; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
D020780:Matrix Metalloproteinase 9