Role of epigenetic regulatory mechanisms in neonatal hypoxic-ischemic brain injury.
Hypoxic-ischemic brain injury is an important cause of neonatal mortality and subsequent serious neurological sequel. In neonatal brain the severity of hypoxic injury varies most probably due to the effects of multiple protective or deleterious factors. But the mechanisms under this difference are still not full understood. In recent years, some evidence has been found supporting the involvement of epigenetic mechanisms in many neurodegenerative diseases and stroke. We hypothesised that epigenetic mechanisms have been also involved in neonatal hypoxic-ischemic brain injury possibly by suppression of ischemia-induced cerebral inflammation and changing the expression of proapoptotic-antiapoptotic genes.
Kumral
Abdullah
A
Dokuz Eylul University Faculty of Medicine, Department of Pediatrics, Subdivision of Neonatology, Izmir, Turkey.
Tuzun
Funda
F
Yesilirmak
Didem
D
Duman
Nuray
N
Ozkan
Hasan
H
D044127:Epigenesis, Genetic / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D002534:Hypoxia, Brain / Q000151:congenital* / Q000235:genetics*; D007231:Infant, Newborn; D008957:Models, Genetic