title: [Physical training at ambulatory-polyclinical stage in complex rehabilitation and secondary prevention of patients with ischemic heart disease after acute incidents. Effect on physical working capacity, hemodynamics, blood lipids, clinical course and prognosis (Russian cooperative study)].
abstract: OBJECTIVE
  To investigate efficacy of early and long term physical training (PT) of moderate intensity in conditions of practical health care in Russia in patients with ischemic heart disease (IHD) of able to work age - survivors of acute coronary events.
  
  
  METHODS
  Three hundred ninety two patients were enrolled in this study. They were randomized into intervention group " O" (n=197) and control group " C" (n=195). Inclusion period was 3- 8 weeks from onset of myocardial infarction (MI), unstable angina (UA), or intervention on coronary arteries. Patients were followed up for 1 year and efficacy of intervention was assessed by results of laboratory (levels of lipids), instrumental (ECG, exercise test on veloergometer, echocardiography), and clinical examination. In the group " O" regimen of PT with work loads of moderate intensity (50-60% of power achieved during exercise test) was used. Duration of FT was 45 - 60 min, frequency - 3 times a week. All patients received standard therapy for IHD and a lipid lowering drug when indicated.
  
  
  RESULTS
  Proofs of efficacy of PT in the given contingent of patients were obtained. This was manifested by significant increase of physical working capacity: prolongation of exercise time (+31.7%, p<0.001), increases of volume of work performed (+74.3%, p<0.001) and efficiency of cardiac work according to results of exercise tests. All parameters were significantly different from those in the group " C" . Structural functional parameters of the heart also improved in the group " O" : left ventricular (LV) stroke volume increased 4.5% (p<0.005), ejection fraction increased 7.2% (p<0.001), diastolic LV volume decreased 2.5% (p<0.05), systolic LV volume decreased 8.1% (p<0.001). In the group " C" stroke volume and LV ejection fraction rose to a lesser degree - by 5.5% (p<0.01) and 2.9% (p<0.05), respectively. Differences between groups in dynamics of these parameters turned out to be significant (p<0.05). Moreover in group " C" LV diastolic volume increased 2.3% (p<0.05) and systolic volume did not change, while left atrium increased 3.4% (p<0.002). At intergroup comparison differences in dynamics of these parameters were significant (p<0.005). Analysis of lipid profile after 1 year showed no changes in patients of group " C" , while in group " O" it revealed significant (3.6%) lowering of total (T) cholesterol (CH) (p<0.05 compared with baseline and change in group " C" ) and elevation of high density lipoprotein (HDL) CH (+12.3%, p<0.001; compared with group " C" p<0.005). Atherogeneity index TCH/HDLCH decreased 8.5% in the group " O" (p<0.01), and increased 12% (p<0.02) in the group " C" , difference between groups was statistically significant (p<0.001). In the group " O" body mass index decreased 2.8% (p<0.001), and frequency of attacks of angina decreased 50.8% (p<0.001; compared with group " C" p<0.001). Statistically significant differences were registered between the following parameters of composite end point and surrogate points: total number of cardiovascular events - 26 (14.8%) vs 47 (27%), p<0.01; number of cardiovascular catastrophes - 5 (3%) vs 15 (8.7%), p<0.05; number of days out of work because of exacerbation of IHD per 1 person/year - 2.4 vs 4.2, p<0.05 in groups " O" and " C" , respectively. Thus in the group " O" positive effect of PT on the course and outcomes of the disease was registered compared with the group " C" .
  
  
  CONCLUSIONS
  The data obtained are indicative of sufficient efficacy of the used program of PT and feasibility of its application in practice of ambulatory rehabilitation of patients with IHD - survivors of acute coronary events. It also can be looked upon as a method of secondary prevention as results of the study showed its positive impact on risk factors and outcomes of the disease.
authors.forename: D M
authors.initials: DM
authors.lastname: Aronov
authors.forename: V B
authors.initials: VB
authors.lastname: Krasnitskiĭ
authors.forename: M G
authors.initials: MG
authors.lastname: Bubnova
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Pozdniakov
authors.forename: D G
authors.initials: DG
authors.lastname: Ioseliani
authors.forename: A N
authors.initials: AN
authors.lastname: Shchegol'kov
authors.forename: G G
authors.initials: GG
authors.lastname: Efremushkin
authors.forename: I V
authors.initials: IV
authors.lastname: Osipova
authors.forename: S F
authors.initials: SF
authors.lastname: Guliaeva
authors.forename: S V
authors.initials: SV
authors.lastname: Mal'chikova
authors.forename: E V
authors.initials: EV
authors.lastname: Kazakevich
authors.forename: N P
authors.initials: NP
authors.lastname: Liamina
authors.forename: I N
authors.initials: IN
authors.lastname: Riamzina
authors.forename: L N
authors.initials: LN
authors.lastname: Mingazetdinova
authors.forename: G S
authors.initials: GS
authors.lastname: Galiautdinov
authors.forename: A N
authors.initials: AN
authors.lastname: Tin'kov
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Grinshteĭn
authors.forename: N K
authors.initials: NK
authors.lastname: Novikova
mesh_terms: D005081:Exercise Therapy; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control* / Q000534:rehabilitation*; D011379:Prognosis; D055502:Secondary Prevention / Q000379:methods*
chemical_list: D008055:Lipids