title: The effect of anti-sensitivity dentifrices on brushing abrasion of eroded dentin in vitro.
abstract: OBJECTIVE
  To investigate the abrasive effects of three marketed anti-sensitivity, and one marketed regular dentifrice on dentin, using an erosion-abrasion in vitro model.
  
  
  METHODS
  Standardized human dentin specimens were prepared and exposed to cycles of erosion, remineralization, and tooth brushing, utilizing the four commercially available dentifrices. Dentin surface loss was then measured by optical profilometry after a total of nine complete cycles. The RDA and pH values of the dentifrices were also measured to assist in the interpretation of results.
  
  
  RESULTS
  Profilometry showed significantly greater dentin surface loss for both Colgate Sensitive Fresh Stripe and Colgate Sensitive Multi Protection when compared with Sensodyne Total Protection or Crest Cavity Protection dentifrices. The abrasive level of dentifrices correlated positively (r-squared = 0.66; p < 0.05) with dentin surface loss.
  
  
  CONCLUSIONS
  This study demonstrated that the abrasivity of dentifrices can have a significant effect on the wear of eroded dentin in vitro.
authors.affiliation: GlaxoSmithKline Consumer Healthcare, Weybridge, Surrey, UK. nathan.l.hughes@gsk.com
authors.forename: Nathan
authors.initials: N
authors.lastname: Hughes
authors.forename: Stephen
authors.initials: S
authors.lastname: Mason
authors.forename: Jonathan
authors.initials: J
authors.lastname: Creeth
authors.forename: Anderson T
authors.initials: AT
authors.lastname: Hara
authors.forename: Madhu
authors.initials: M
authors.lastname: Parmar
authors.forename: Carlos
authors.initials: C
authors.lastname: González-Cabezas
mesh_terms: D045424:Complex Mixtures / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D003802:Dentifrices / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use; D003804:Dentin / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000150:complications / Q000188:drug therapy*; D004338:Drug Combinations; D005459:Fluorides / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D009566:Nitrates / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D010710:Phosphates / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D017680:Potassium Compounds / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D011897:Random Allocation; D012824:Silicic Acid; D012822:Silicon Dioxide / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D014072:Tooth Abrasion / Q000139:chemically induced*; D014077:Tooth Erosion / Q000150:complications; D014092:Tooth Root; D014100:Toothpastes
chemical_list: D045424:Complex Mixtures; D003802:Dentifrices; D004338:Drug Combinations; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; C097427:Sensodyne; D014100:Toothpastes; C444700:colgate sensitive; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D005459:Fluorides