A practical, two-step synthesis of 2-substituted 1,3-butadienes.
A two-step procedure for preparing 2-alkyl-1,3-butadienes is described. Cuprate addition to commercially available 1,4-dibromo-2-butene yields 3-alkyl-4-bromo-1-butene, a product of S(N)2' substitution. Dehydrohalogenation gives 2-alkyl-1,3-butadienes.
Sen
Sushmita
S
Department of Chemistry, Temple University, 1901 North 13th Street, Philadelphia, Pennsylvania 19122, USA.
Singh
Swapnil
S
Sieburth
Scott McN
SM
D002070:Butadienes / Q000138:chemical synthesis* / Q000737:chemistry; D054879:Halogenation; D015394:Molecular Structure
D002070:Butadienes