HIV-1 Vpr: regulator of viral survival.
The HIV-1 Vpr protein is a viral accessory protein that plays a number of important roles during HIV infection. The activities of Vpr are numerous and include the induction of apoptosis, the modulation of cell cycle arrest, as well as control of viral transcription. Study of HIV clones lacking Vpr in vitro and analysis of HIV variants isolated from long-term nonprogressors in vivo highlight the importance of Vpr for viral replication as well as immune suppression and cell death. Vpr may therefore be considered among the most important accessory proteins encoded by HIV.
Thieu
Khanh P
KP
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Morrow
Matthew P
MP
Shedlock
Devon J
DJ
Schoenly
Kimberly A
KA
Mallilankaraman
Karthikbabu
K
Choo
Andrew Y
AY
Fagone
Paolo
P
Weiner
David B
DB
Muthumani
Karuppiah
K
D015497:HIV-1 / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007108:Immune Tolerance; D014779:Virus Replication; D054325:vpr Gene Products, Human Immunodeficiency Virus / Q000502:physiology*
D054325:vpr Gene Products, Human Immunodeficiency Virus; C514912:vpr protein, Human immunodeficiency virus 1