title: Interferon-alpha for treatment of essential thrombocythemia during pregnancy: case report and review of the literature.
abstract: Described as a myeloproliferative disorder mainly affecting elderly women, recent reports now confirm the occurrence of essential thrombocythemia at younger ages, which questions treatment during pregnancy. We report a further case of uneventful full term pregnancy with the use of interferon-alpha for maternal essential thrombocythemia which suggests that interferon-alpha could be considered as an effective and safe treatment during pregnancy for women with essential thrombocythemia. Further studies are warranted to determine whether interferon-alpha is the optimal therapeutic option during pregnancy for this patient population.
authors.affiliation: Department of Obstetrics and Gynecology, Rouen University Hospital, Rouen, France.
authors.forename: Jérémy
authors.initials: J
authors.lastname: Séror
authors.forename: Loïc
authors.initials: L
authors.lastname: Sentilhes
authors.forename: Céline
authors.initials: C
authors.lastname: Lefebvre-Lacoeuille
authors.forename: Loïc
authors.initials: L
authors.lastname: Marpeau
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D018811:Maternal Exposure; D011247:Pregnancy; D018570:Risk Assessment; D013920:Thrombocythemia, Essential / Q000188:drug therapy*
chemical_list: D016898:Interferon-alpha