Mouse models for human otitis media.
Otitis media (OM) remains the most common childhood disease and its annual costs exceed $5 billion. Its potential for permanent hearing impairment also emphasizes the need to better understand and manage this disease. The pathogenesis of OM is multifactorial and includes infectious pathogens, anatomy, immunologic status, genetic predisposition, and environment. Recent progress in mouse model development is helping to elucidate the respective roles of these factors and to significantly contribute toward efforts of OM prevention and control. Genetic predisposition is recognized as an important factor in OM and increasing numbers of mouse models are helping to uncover the potential genetic bases for human OM. Furthermore, the completion of the mouse genome sequence has offered a powerful set of tools for investigating gene function and is generating a rich resource of mouse mutants for studying the genetic factors underlying OM.
Trune
Dennis R
DR
Oregon Hearing Research Center, Mail Code NRC04, Oregon Health & Science University, 3181 S.W. Sam Jackson Park Road, Portland, OR 97239-3098, USA.
Zheng
Qing Yin
QY
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D016233:Immunotherapy, Active; D051379:Mice; D010033:Otitis Media / Q000235:genetics* / Q000276:immunology / Q000382:microbiology* / Q000628:therapy; D051193:Toll-Like Receptors / Q000378:metabolism
D051193:Toll-Like Receptors