Pharmacology of antineoplastic medications in older cancer patients.
Older patients are more susceptible to the complications of chemotherapy, and may be less equipped to react to these complications. After an introduction to the basic principles of geriatric medicine, this article explores the treatment of older cancer patients with systemic chemotherapy, including discussions of the pharmacology of aging, the effectiveness and toxicity of antineoplastic treatment in this population, and issues that need to be addressed in future clinical trials.
Balducci
Lodovico
L
Senior Adult Oncology Program, Moffitt Cancer Center, Tampa, Florida 33612, USA. Lodovico.balducci@moffitt.org
D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000627:therapeutic use; D004347:Drug Interactions; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans
D000970:Antineoplastic Agents