[Surgical treatment of diabetes mellitus type 2].
The resolution of diabetes after gastric bypass is already observed during the first days after the operation, while the control of diabetes after gastric banding occurs after weight loss. Other mechanisms than weight loss must therefore explain the improved glucose tolerance. Focus has been on appetite-regulating gut hormone, particularly peptide YY and glucagon-like peptide-1. Nevertheless, other unknown hormones or mechanisms may be involved in the dramatic changes in the glucose metabolism. Development of new drugs and treatments based on the endocrine changes observed after bariatric surgery with the aim of curing type 2-diabetes are warranted.
Olesen
Stine Chabert
SC
Hvidovre Hospital.
Hansen
Dorte Lindqvist
DL
Almdal
Thomas
T
Bendtsen
Flemming
F
Nordgaard
Inge
I
Hvolris
Lisbeth Edvardsen
LE
Holst
Jens J
JJ
Naver
Lars
L
Madsbad
Sten
S
D000713:Anastomosis, Roux-en-Y; D050110:Bariatric Surgery; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery*; D015390:Gastric Bypass; D015391:Gastroplasty; D005947:Glucose / Q000378:metabolism; D006801:Humans; D012074:Remission Induction
D005947:Glucose