Lung transplantation: does oxidative stress contribute to the development of bronchiolitis obliterans syndrome?
Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%. However, 5-year survival rates drop to 50% due to bronchiolitis obliterans syndrome (BOS). Ischemia/reperfusion injury, infections, and acute rejection are major risk factors contributing to the development of BOS. These risk factors are also associated with increased oxidative stress. Oxidative stress is a condition whereby prooxidants overwhelm the antioxidant defense system and may contribute to the pathogenesis of BOS by inducing more tissue injury and inflammation. This article reviews the current state of knowledge on oxidative stress in lung transplantation and BOS.
Madill
Janet
J
University of Toronto, Lung Transplant Program, University Health Network, Toronto, ON, Canada.
Aghdassi
Ellie
E
Arendt
Bianca
B
Hartman-Craven
Brenda
B
Gutierrez
Carlos
C
Chow
Chung-Wai
CW
Allard
Johane
J
D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality; D018384:Oxidative Stress / Q000502:physiology*; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism / Q000401:mortality; D012307:Risk Factors