Asymmetric Suzuki-Miyaura coupling in water with a chiral palladium catalyst supported on an amphiphilic resin.
You oughta use water: Broad functional-group (FG) tolerance was observed for the title coupling of aryl halides (X = Cl, Br, I) and aryl boronic acids to give biaryl compounds with up to 94% ee. The chiral imidazoindole phosphine-palladium catalyst supported on an amphiphilic polystyrene-poly(ethylene glycol) (PS-PEG) resin could be recycled readily.
Uozumi
Yasuhiro
Y
Institute for Molecular Science and The Graduate School for Advanced Studies, Myodaiji, Okazaki, Aichi 444-8787, Japan. uo@ims.ac.jp
Matsuura
Yutaka
Y
Arakawa
Takayasu
T
Yamada
Yoichi M A
YM