title: [Guillain-Barre syndrome in the paediatric age: epidemiological, clinical and therapeutic profile in a hospital in El Salvador].
abstract: BACKGROUND
  Guillain-Barre syndrome (GBS) is an acute polyradiculoneuropathy with, in most cases, an autoimmune aetiology. It manifests as a flaccid motor paralysis, of a distal ascending type, accompanied by areflexia with or without sensory alterations.
  
  
  OBJECTIVE
  To determine the clinical and therapeutic epidemiological profile of patients diagnosed as suffering from GBS who were attended at the Benjamin Bloom Children's Hospital in El Salvador, between 1st January 1997 and 31st December 2004.
  
  
  METHODS
  We performed an observation-based, descriptive, cross-sectional study that included 414 cases. The following data were evaluated: age distribution, sex, age, history of infections, clinical manifestations, results of the lumbar puncture, electrophysiological studies and treatment that was received.
  
  
  RESULTS
  A predominance of males was observed, together with a more frequent presentation in school-age children. The number of cases increased in the third quarter of each of the years included in the study. The most prevalent event in the history of infections was acute respiratory infection. And the most frequent clinical presentation was ascending weakness. Albuminocytological dissociation was detected in 88% of patients who had undergone lumbar puncture. Acute inflammatory demyelinating polyneuropathy predominated in 88.3% of cases. Sixty per cent of patients had to be admitted to the intensive care unit. In most cases treatment consisted in intravenous administration of immunoglobulin. Complications occurred in 30.5% of cases and the mortality rate was 2.9%.
  
  
  CONCLUSIONS
  GBS occurs predominantly in the rainiest season of the year, which is related to an increase in the number of infections in the upper respiratory tract and gastroenteric infections that give rise to a predisposition to present secular outbreaks of the disease.
authors.affiliation: Servicio de Neuropediatría, Hospital de Niños Benjamín Bloom, Facultad de Medicina, Universidad de El Salvador, San Salvador, República de El Salvador.
authors.forename: M
authors.initials: M
authors.lastname: Ramírez-Zamora
authors.forename: C R
authors.initials: CR
authors.lastname: Burgos-Ganuza
authors.forename: D A
authors.initials: DA
authors.lastname: Alas-Valle
authors.forename: P E
authors.initials: PE
authors.lastname: Vergara-Galán
authors.forename: C I
authors.initials: CI
authors.lastname: Ortez-González
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004544:El Salvador / Q000453:epidemiology; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology* / Q000628:therapy; D006776:Hospitals, Pediatric; D006801:Humans; D008297:Male; D011379:Prognosis; D011891:Rain; D012621:Seasons