Inhibition of lung metastasis in mice by oligonol.
Oligonol is a polyphenol formulation enriched with catechin-type oligomers. As an initial approach to assess the chemopreventive potential of Oligonol, the study investigated the effects of Oligonol on the inhibition of lung metastasis induced by B16F-10 melanoma cells in C57BL/6 mice. Oligonol, which is abundantly found in plants, vegetables and fruits, was found to possess antimetastatic activity against B16F-10 melanoma cells. Continued consumption of Oligonol, even at high doses, for long periods does not seem to cause any toxic symptoms because excess Oligonol is stored in adipose tissue rather than in the liver. However, the mechanism by which Oligonol exerts its antimetastatic activity remains unclear. Further investigations are required to clarify the exact role of Oligonol in such B16F-10 melanoma regulation.
Lee
Sung-Jae
SJ
Department of Integrative Medicine, College of Medicine, Korea University, Seoul 136-705, South Korea.
Chung
Ill-Min
IM
Kim
Min-Young
MY
Park
Keum-Duk
KD
Park
Won-Hwan
WH
Park
Won-Wan
WW
Moon
Hyung-In
HI
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003094:Collagen / Q000378:metabolism; D006595:Hexosamines / Q000032:analysis; D006909:Hydroxyproline / Q000378:metabolism; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008175:Lung Neoplasms / Q000517:prevention & control* / Q000556:secondary; D008546:Melanoma, Experimental / Q000556:secondary; D051379:Mice; D008810:Mice, Inbred C57BL; D010636:Phenols / Q000627:therapeutic use*; D012794:Sialic Acids / Q000097:blood; D014574:Uronic Acids / Q000032:analysis; D005723:gamma-Glutamyltransferase / Q000097:blood
D000972:Antineoplastic Agents, Phytogenic; D006595:Hexosamines; D010636:Phenols; D012794:Sialic Acids; D014574:Uronic Acids; C514283:oligonol; D002392:Catechin; D003094:Collagen; D005723:gamma-Glutamyltransferase; D006909:Hydroxyproline