title: Protective role of vitamin E on nickel and/or chromium induced oxidative stress in the mouse ovary.
abstract: In the present study, we report the invivo effects of nickel chloride (NiCl2; 8 and 16 mg/kg body weight) and/or potassium dichromate (K2Cr2O7; 5 and 10mg/kg body weight) in the ovary of adult mice. The protective role of vitamin E (2mg/kg body weight) along with their combination was also studied. Nickel and/or chromium to mice enhanced the levels of lipid peroxides in the ovary, which was accompanied by a significant decline in the levels of protein, glutathione, total ascorbic acid and activities of superoxide dismutase and catalase. Supplementation of vitamin E along with NiCl2 + K2Cr2O7 significantly lowered the levels of lipid peroxidation and enhanced the antioxidant status. Findings of the present study suggest that vitamin E exerts its protective effect against nickel and/or chromium induced toxicity by preventing lipid peroxidation and protecting antioxidant system in the mouse ovary.
authors.affiliation: Zoology Department, University School of Sciences, Gujarat University, Ahmedabad 380 009, Gujarat, India. zooldeptgu@satyam.net.in
authors.forename: Mandava V
authors.initials: MV
authors.lastname: Rao
authors.forename: Sunita L
authors.initials: SL
authors.lastname: Chawla
authors.forename: Seema R
authors.initials: SR
authors.lastname: Sharma
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D017608:Chromium Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D005260:Female; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009532:Nickel / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D011192:Potassium Dichromate / Q000633:toxicity; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D017608:Chromium Compounds; D014810:Vitamin E; D008315:Malondialdehyde; D009532:Nickel; D011192:Potassium Dichromate