title: [Thrombosis of the cavernous sinus following prone-position spinal surgery in a patient with factor V Leiden].
abstract: BACKGROUND
  Non-infectious thrombosis of the cavernous sinus has sometimes been reported as a complication following neurosurgical procedures and, in one case, after carrying out the operation in a prone position. Factor V Leiden is a genetic risk factor for presenting an intracranial venous thrombotic disease. We report the case of a patient who suffered thrombosis of the cavernous sinus following prolonged surgery in the prone position and in whom a mutation of factor V Leiden in a heterozygotic state was discovered.
  
  
  METHODS
  A 64-year-old male, with arterial hypertension as the only known vascular risk factor, who, after prolonged surgery in a prone position, presented amaurosis in the left eye accompanied some hours later by ocular pain, conjunctival ecchymosis, proptosis and abolition of extrinsic ocular mobility. An angiography scan confirmed the existence of thrombosis in the cavernous sinus. Treatment was established with low-molecular-weight heparin without the occurrence of any other kinds of complications. The patient gradually recovered extrinsic ocular mobility but not visual acuity. A heterozygotic mutation for factor V Leiden was found in a hypercoagulability study that was later performed.
  
  
  CONCLUSIONS
  The coexistence of a risk factor for presenting a venous thrombotic disease and a mechanical phenomenon, venous statis, due to the posture adopted for the surgical intervention together account for the complication presented by the patient.
authors.affiliation: Sección de Neurología, Hospital de Cabueñes, Gijón, Asturias, Spain. nacasame@yahoo.es
authors.forename: I
authors.initials: I
authors.lastname: Casado-Menéndez
authors.forename: C
authors.initials: C
authors.lastname: González-Rodríguez
authors.forename: M
authors.initials: M
authors.lastname: Díaz-González
authors.forename: A
authors.initials: A
authors.lastname: Gómez Díaz-Castroverde
authors.forename: M
authors.initials: M
authors.lastname: Fayad
authors.forename: R
authors.initials: R
authors.lastname: de la Cruz
mesh_terms: D002426:Cavernous Sinus / Q000033:anatomy & histology / Q000473:pathology; D005165:Factor V / Q000009:adverse effects* / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures / Q000009:adverse effects*; D016684:Prone Position; D012307:Risk Factors; D013131:Spine / Q000601:surgery*; D013927:Thrombosis / Q000209:etiology*
chemical_list: C095381:factor V Leiden; D005165:Factor V