Lack of efficacy of prophylactic platelet transfusion for severe thrombocytopenia in adults with acute uncomplicated dengue infection.
Thrombocytopenia in dengue infection raises concerns about bleeding risk. Of 256 patients with dengue infection who developed thrombocytopenia (platelet count, < 20 x 10(3) platelets/microL) without prior bleeding, 188 were given platelet transfusion. Subsequent bleeding, platelet increment, and platelet recovery were similar between patients given transfusion and patients not given transfusion. Prophylactic platelet transfusion was ineffective in preventing bleeding in adult patients with dengue infection.
Lye
David C
DC
Department of Infectious Disease, Tan Tock Seng Hospital, National Healthcare Group, Singapore.
Lee
Vernon J
VJ
Sun
Yan
Y
Leo
Yee Sin
YS
D000293:Adolescent; D000328:Adult; D003715:Dengue / Q000150:complications*; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D017713:Platelet Transfusion; D020127:Recovery of Function; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000517:prevention & control*; D016896:Treatment Outcome; D055815:Young Adult