Sharing data between LSDBs and central repositories.
Several Locus-Specific DataBases (LSDBs) have recently been approached by larger, more general data repositories (including NCBI and UCSC) with the request to share the DNA variant data they have collected. Within the Human Genome Variation Society (HGVS) a document was generated summarizing the issues related to these requests. The document has been circulated in the HGVS/LSDB community and was discussed extensively. Here we summarize these discussions and present the concluded recommendations for LSDB data sharing with central repositories.
den Dunnen
Johan T
JT
Leiden University Medical Center, Albinusdreef 2, Leiden, The Netherlands. ddunnen@lumc.nl
Sijmons
Rolf H
RH
Andersen
Paal S
PS
Vihinen
Mauno
M
Beckmann
Jacques S
JS
Rossetti
Sandro
S
Talbot
C Conover
CC
Hardison
Ross C
RC
Povey
Sue
S
Cotton
Richard G H
RG
D019295:Computational Biology / Q000379:methods / Q000592:standards; D030541:Databases, Genetic; D014644:Genetic Variation; D015894:Genome, Human / Q000235:genetics*; D006801:Humans; D033181:Information Dissemination; D009154:Mutation; D020641:Polymorphism, Single Nucleotide