Induction of gene encoding FABP4 in Pten-null keratinocytes.
Keratinocyte-specific Pten-null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that contribute to their phenotypes, we analyzed a comprehensive gene expression of Pten-null keratinocytes using microarray technology. Consequently, it was demonstrated that the most induced gene was adipocyte-specific fatty acid-binding protein (FABP4). Collectively, it is conceivable that the FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice.
Tsuda
Masaaki
M
Department of Dermatology and Plastic Surgery, Akita University School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan.
Inoue-Narita
Tae
T
Suzuki
Akira
A
Itami
Satoshi
S
Blumenberg
Miroslav
M
Manabe
Motomu
M
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D020869:Gene Expression Profiling; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000502:physiology*
D017931:DNA Primers; C493411:Fabp4 protein, mouse; D050556:Fatty Acid-Binding Proteins; D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse