title: New cytotoxic lupane triterpenes from Perrottetia arisanensis.
abstract: Eight new lupane triterpenes, including 7beta-cis-coumaroylbetulinic acid (1), 7beta-trans-coumaroylbetulinic acid (2), 7beta-cis-coumaroyl-3-epi-betulinic acid (3), 7beta-trans-coumaroyl-3-epi-betulinic acid (4), 7beta-cis-coumaroylbetulonic acid (5), 7beta-trans-coumaroylbetulonic acid (6), 7beta-hydroxybetulinaldehyde (7) and 28-norlup-20(29)-ene-3alpha,17beta-diol (8), together with fifteen known compounds were isolated from the bioactive methanol extract of the stems of Perrottetia arisanensis. The structures of the new compounds were elucidated by spectroscopic and HR-ESI-MS analysis. All new compounds were evaluated for their cytotoxicity against six human cancer cell lines. Among them, lupane triterpene coumaroyl esters 1-6 showed moderate cytotoxicity with IC (50) values ranging from 3.75 to 21.29 microM. This is the first report for lupane triterpenes with a phenylpropane moiety substituted at C-7.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Ying-Chi
authors.initials: YC
authors.lastname: Du
authors.forename: An-Shen
authors.initials: AS
authors.lastname: Lin
authors.forename: Chin-Chung
authors.initials: CC
authors.lastname: Wu
authors.forename: Pei-Wen
authors.initials: PW
authors.lastname: Hsieh
authors.forename: Yung-Husan
authors.initials: YH
authors.lastname: Chen
authors.forename: I-Hsiao
authors.initials: IH
authors.lastname: Chen
authors.forename: Shu-Li
authors.initials: SL
authors.lastname: Chen
authors.forename: Hsin-Fu
authors.initials: HF
authors.lastname: Yen
authors.forename: Tilo
authors.initials: T
authors.lastname: Lübken
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Chang
authors.forename: Yang-Chang
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D019684:Magnoliopsida; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D018547:Plant Stems; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014315:Triterpenes