Pharmacokinetic interaction of single dose of piperine with steady-state carbamazepine in epilepsy patients.
Piperine, the active principle of piper species, is commonly used as a spice and adjuvant in various traditional systems of medicine. It has been known as a bioavailability-enhancer. The present study aimed at evaluating the effect of piperine on the steady-state pharmacokinetics of a single dose of carbamazepine in poorly controlled epilepsy patients on carbamazepine monotherapy. Patients (n = 10 each) receiving either 300 mg or 500 mg dose of carbamazepine twice daily were selected. After administration of carbamazepine, venous blood samples were collected at 0, 0.5, 1, 2, 4, 6, 9, 12 h. Subsequently, piperine (20 mg p.o.) was administered along with carbamazepine and samples were collected similarly. The pharmacokinetic parameters were compared by Students t-test. Piperine significantly increased the mean plasma concentrations of carbamazepine at most of the time points in both dose groups. There was a significant increase in AUC(0-12hr) (p < 0.001), average C(ss) (p < 0.001), t(1\2el) (p < 0.05) and a decrease in K(el) (p < 0.05), in both the dose groups, whereas changes in K(a) and t(1\2a) were not significant. Cmax (p < 0.01) and t(max) (p < 0.01) were increased significantly following piperine administration in the 500 mg dose group; however, these parameters were not significant in the lower dose group. Piperine could significantly enhance the oral bioavailability of carbamazepine, possibly by decreasing the elimination and/or by increasing its absorption.
Pattanaik
Smita
S
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh-160012, India.
Hota
Debasish
D
Prabhakar
Sudesh
S
Kharbanda
Parampreet
P
Pandhi
Promila
P
D000328:Adult; D000470:Alkaloids / Q000493:pharmacokinetics*; D019540:Area Under Curve; D052117:Benzodioxoles / Q000493:pharmacokinetics*; D001682:Biological Availability; D002220:Carbamazepine / Q000097:blood / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D031701:Piper / Q000737:chemistry; D010880:Piperidines / Q000493:pharmacokinetics*; D053284:Polyunsaturated Alkamides / Q000493:pharmacokinetics*; D055815:Young Adult
D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D002220:Carbamazepine; C008922:piperine