Lymphocyte kinetics in health and disease.
Quantitative understanding of immunology requires the development of experimental and mathematical techniques for estimation of rates of division and death of lymphocytes under different conditions. Here, we review the advantages and limitations of several labelling methods that are currently used to quantify turnover of lymphocytes in vivo. In addition to highlighting insights into lymphocyte kinetics which have recently been gained thanks to the development of novel techniques, we discuss important directions for future experimental and theoretical work in the field of lymphocyte turnover.
Asquith
Becca
B
Department of Immunology, Wright-Fleming Institute, Imperial College London, London W2 1PG, UK.
Borghans
José A M
JA
Ganusov
Vitaly V
VV
Macallan
Derek C
DC
D000375:Aging; D000818:Animals; D016923:Cell Death; D002465:Cell Movement; D049109:Cell Proliferation; D019295:Computational Biology; D003198:Computer Simulation; D005947:Glucose / Q000276:immunology; D006706:Homeostasis; D006801:Humans; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007553:Isotope Labeling; D007938:Leukemia / Q000276:immunology* / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*
D005947:Glucose