title: Review: Ischaemia-reperfusion injury in flap surgery.
abstract: Ischaemia-reperfusion injury is the mechanism underlying (partial) flap loss. This is not only a traumatic event for the patient, it also causes increased patient morbidity [Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165-75] as well as prolonged hospitalisation, increasing medical consumption and costs. For surgeons who perform flap surgery, it is important to have knowledge of ischaemia-reperfusion injury in order to prevent it. In this article, an update on the recent research on ischaemia-reperfusion is given. The production of reactive oxygen species, neutrophil influx, depletion of NO and apoptosis are discussed as well.
authors.affiliation: Department of Plastic, Reconstructive and Hand Surgery, Maastricht University Medical Centre, PO Box 5800-6202 AZ, Maastricht, The Netherlands. m.vandenheuvel@AH.unimaas.nl
authors.forename: Marieke G W
authors.initials: MG
authors.lastname: van den Heuvel
authors.forename: Wim A
authors.initials: WA
authors.lastname: Buurman
authors.forename: Aalt
authors.initials: A
authors.lastname: Bast
authors.forename: René R W J
authors.initials: RR
authors.lastname: van der Hulst
mesh_terms: D017209:Apoptosis; D006801:Humans; D020556:Neutrophil Infiltration; D009569:Nitric Oxide / Q000172:deficiency; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000378:metabolism* / Q000473:pathology / Q000517:prevention & control; D013524:Surgical Flaps / Q000098:blood supply* / Q000473:pathology
chemical_list: D017382:Reactive Oxygen Species; D009569:Nitric Oxide