Ewing's sarcoma / primitive neuroectodermal tumor of the kidney.
A 42-year-old female presented with right back pain. The CT scan revealed a 72-mm space-occupying lesion in the middle portion of the right kidney. No metastasis was proven. She underwent laparoscopic radical nephrectomy and lymph node disection. The histopathological examination revealed a high-grade primitive small round tumor the cells of which were strongly positive for CD99 and vimentin. Fluorescence in situ hybridization analysis using a DNA probe for the Ewing sarcoma breakpoint region 1 (EWSR 1) on chromosome 22g12 revealed a rearrangement of the EWSR 1 locus. The diagnosis was Ewing's sarcoma / primitive neuroectodermal tumor of the kidney. She underwent 13 cycles of chemotherapy, and has no evidence of recurrence 19 months after surgery.
Funahashi
Y
Y
Department of Urology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan. funa418@yahoo.co.jp
Hattori
R
R
Yamamoto
T
T
Mizutani
K
K
Yoshino
Y
Y
Matsukawa
Y
Y
Sassa
N
N
Okumura
K
K
Gotoh
M
M
D000328:Adult; D014408:Biomarkers, Tumor / Q000235:genetics; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D017024:Chemotherapy, Adjuvant; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D015321:Gene Rearrangement / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007668:Kidney / Q000473:pathology; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D010535:Laparoscopy; D008197:Lymph Node Excision; D009392:Nephrectomy; D018242:Neuroectodermal Tumors, Primitive / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins / Q000235:genetics; D011877:Radionuclide Imaging; D012512:Sarcoma, Ewing / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D002148:Calmodulin-Binding Proteins; C500986:EWSR1 protein, human; D034802:RNA-Binding Protein EWS; D016601:RNA-Binding Proteins