[Comparison of two kinds of methods to prepare Chinese medicine Danggui Buxue formula pellets].
The pellet-preparating theories and processes of two kinds of methods of extrusion-spheronization and fluid-bed coating method were compared. The micromeritic properties, yield and in vitro dissolution of Danggui Buxue pellets prepared by the two methods were determined. Results showed that the Danggui Buxue pellets prepared by extrusion-spheronization were all spheral with smooth surface, the yield of those pellets was higher and in vitro dissolution of those pellets was more satisfactory. So the two kinds of methods were all suitable to prepare Dang-gui-bu-xue pellets, but Extrusion-spheronization was superior to fluid-bed coating method.
Chen
Hong-Xia
HX
School of Pharmacy, Jiangsu University, Zhenjiang 212013, China.
Jia
Xiao-Bin
XB
Fan
Chen-Yi
CY
Shi
Ya-Fang
YF
Wei
Hui-Hua
HH
D029971:Angelica sinensis; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004304:Dosage Forms; D004339:Drug Compounding / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*
D004304:Dosage Forms; D004365:Drugs, Chinese Herbal; C044613:angelicae sinensis extract