title: Is there a role for enucleation in the management of ameloblastoma?
abstract: This study aimed to determine the appropriate long-term management for ameloblastoma and the role of enucleation in the management of the subtypes of ameloblastoma (solid ameloblastomas, cystic ameloblastomas and peripheral ameloblastomas). They differ in their degrees of aggressive behavior and recurrence rates. This is an evidence-based study with review of relevant articles from PubMed, EMBASE and the Cochrane Library. Articles were categorized for quality according to the Oxford Center of Evidence-Based Medicine (CEBM). 58 articles met the inclusion criteria; their evidence level varied from IIA to V. No randomized control trials were identified. Solid and multicystic ameloblastomas have a high recurrence rate (60-80%) with simple enucleation and require more aggressive treatment. The treatment of choice is resection with 1-cm margins. This may require segmental resection in the mandible, and partial maxillectomy in the maxilla. For the unicystic ameloblastoma recurrence rates are high for simple enucleation. The intraluminal subtype of unicystic ameloblastoma may do well with enucleation, but the intramural subtype may not, and since these cannot be identified preoperatively more aggressive treatment is recommended, including peripheral ostectomy or enucleation with subsequent treatment of the surrounding bone with liquid nitrogen, Carnoy's solution, or similar physicochemical modality. The peripheral ameloblastoma has a different origin and responds to local excision.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of California-San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143-0440, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Pogrel
authors.forename: D M
authors.initials: DM
authors.lastname: Montes
mesh_terms: D019342:Acetic Acid / Q000627:therapeutic use; D000564:Ameloblastoma / Q000145:classification / Q000601:surgery*; D002725:Chloroform / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003452:Cryosurgery; D000431:Ethanol / Q000627:therapeutic use; D055094:Evidence-Based Dentistry; D006801:Humans; D007573:Jaw Neoplasms / Q000601:surgery*; D008334:Mandible / Q000601:surgery; D008339:Mandibular Neoplasms / Q000601:surgery; D008437:Maxilla / Q000601:surgery; D008441:Maxillary Neoplasms / Q000601:surgery; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010027:Osteotomy / Q000379:methods; D016032:Randomized Controlled Trials as Topic
chemical_list: C033474:Carnoy's solution; D000431:Ethanol; D002725:Chloroform; D019342:Acetic Acid