title: Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy.
abstract: A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.
authors.affiliation: Division of Medicinal Chemistry, Faculty of Sciences, Leiden/Amsterdam Center for Drug Research, VU University Amsterdam, Amsterdam, The Netherlands.
authors.forename: Maikel
authors.initials: M
authors.lastname: Wijtmans
authors.forename: Dennis
authors.initials: D
authors.lastname: Verzijl
authors.forename: Cindy M E
authors.initials: CM
authors.lastname: van Dam
authors.forename: Leontien
authors.initials: L
authors.lastname: Bosch
authors.forename: Martine J
authors.initials: MJ
authors.lastname: Smit
authors.forename: Rob
authors.initials: R
authors.lastname: Leurs
authors.forename: Iwan J P
authors.initials: IJ
authors.lastname: de Esch
mesh_terms: D000218:Adamantane / Q000737:chemistry; D000586:Amination; D001665:Binding Sites / Q000502:physiology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis; D001892:Camphanes / Q000737:chemistry; D002460:Cell Line; D006801:Humans; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000378:metabolism*; D054367:Receptors, CXCR3 / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; C515187:CXCR3 protein, human; D001892:Camphanes; D011083:Polycyclic Compounds; D054367:Receptors, CXCR3; C067796:camphane; D000218:Adamantane