title: Macrophage activation syndrome: serological markers and treatment with anti-thymocyte globulin.
abstract: Two patients presented at the University of Rochester Medical Center with a febrile illness, cytopenias, organ failure (liver failure or respiratory failure), and markedly elevated serum ferritin and sIL-2R. A diagnosis of probable macrophage activation syndrome was made. Both patients failed initial therapy with steroids and cyclosporine, either due to toxicity or lack of efficacy. Both patients responded dramatically to rabbit anti-thymocyte globulin (ATG).
authors.affiliation: University of Rochester, Department of Medicine, Allergy Immunology Rheumatology Division, Room G-6427C, 601 Elmwood Avenue, Rochester, New York 14642, USA.
authors.forename: Andreea
authors.initials: A
authors.lastname: Coca
authors.forename: Kemp W
authors.initials: KW
authors.lastname: Bundy
authors.forename: Bethany
authors.initials: B
authors.lastname: Marston
authors.forename: Jennifer
authors.initials: J
authors.lastname: Huggins
authors.forename: R John
authors.initials: RJ
authors.lastname: Looney
mesh_terms: D015703:Antigens, CD / Q000097:blood; D015214:Antigens, Differentiation, Myelomonocytic / Q000097:blood; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D055501:Macrophage Activation Syndrome / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy*; D011956:Receptors, Cell Surface / Q000097:blood; D015375:Receptors, Interleukin-2 / Q000097:blood; D055815:Young Adult; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000961:Antilymphocyte Serum; D015415:Biomarkers; D000098902:CD163 Antigen; D007166:Immunosuppressive Agents; D011956:Receptors, Cell Surface; D015375:Receptors, Interleukin-2; D005293:Ferritins