title: Biological activity of secondary metabolites from Peltostigma guatemalense.
abstract: Leaves and wood of Peltostigma guatemalense, a novel species of the family Rutaceae, yielded a total of 14 secondary metabolites, i.e. methyl p-hydroxy benzoate, phenylacetic acid, beta-sitosterol, lupeol, syringaresinol, scopoletin, gardenin B (1), and seven alkaloids: gamma-fagarine (2), skimmianine (3), kokusaginine (4), 7-O-isopentenyl-gamma-fagarine (5), anhydro-evoxine (6), evoxine (7) and 4-methoxy-1-methyl-quinolin-2-one (8). The compounds have been identified by spectroscopic methods. Antibacterial and antimalarial in vitro activity of the isolated compounds were also determined. Methyl p-hydroxy benzoate and quinolone (8) were the most effective on Plasmodium falciparium strains.
authors.affiliation: Departamento de Quimica, Universidad Nacional de Colombia, Bogota, Colombia.
authors.forename: Luis Enrique
authors.initials: LE
authors.lastname: Cuca Suarez
authors.forename: Manuel Elkin
authors.initials: ME
authors.lastname: Pattarroyo
authors.forename: Jose Manuel
authors.initials: JM
authors.lastname: Lozano
authors.forename: Franco
authors.initials: F
authors.lastname: Delle Monache
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D000094042:Lupanes
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000962:Antimalarials; D005663:Furans; D017705:Lignans; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D011804:Quinolines; D012855:Sitosterols; D014315:Triterpenes; C042192:syringaresinol; C035932:skimmianine; C049193:gamma-fagarine; C025473:gamma-sitosterol; C010480:lupeol; D000094042:Lupanes