Integrin switching modulates adhesion dynamics and cell migration.
When cells are stimulated to move, for instance during development, wound healing or angiogenesis, they undergo changes in the turnover of their cell-matrix adhesions. This is often accompanied by alterations in the expression profile of integrins-the extracellular matrix receptors that mediate anchorage within these adhesions. Here, we discuss how a shift in expression between two different types of integrins that bind fibronectin can have dramatic consequences for cell-matrix adhesion dynamics and cell motility.
Truong
Hoa
H
Leiden Amsterdam Center for Drug Research, Leiden University, Netherlands.
Danen
Erik H J
EH
D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D016023:Integrins / Q000502:physiology*
D016023:Integrins