The use of estrogen therapy in women's sexual functioning (CME).
BACKGROUND
Estrogen is relevant to women's well-being including sexual functioning. Aim. The goal of this Continuing Medical Education article was to provide a comprehensive review of the effect of exogenous estrogen use on women's sexual function. Main Outcome Measures. We present a literature review.


METHODS
The medical literature was accurately searched (1990-2008) with regard to estrogen therapy in menopausal women by using several terms related to and including the terms "estrogen" and "sexual function."


RESULTS
A review of the studies most useful to guide menopausal practice.


CONCLUSIONS
Estrogen decline is one of the key factors contributing to sexual functioning during menopausal transition and beyond. Systemic estrogen treatments are associated with significant benefits in some domains of menopausal sexual function, especially when estradiol is delivered transdermally, whereas local estrogens are effective in preventing urogenital aging. Even tibolone, a selective tissue estrogenic activity regulator, displays positive effects in postmenopausal women with sexual complaints. However, a tailored approach to the individual woman is always needed.
Nappi
Rossella E
RE
Department of Morphological, University of Pavia-Research Center for Reproductive Medicine, Pavia, Italy. renappi@tin.it
Polatti
Franco
F
D000279:Administration, Cutaneous; D000368:Aged; D001284:Atrophy; D004958:Estradiol / Q000627:therapeutic use*; D020847:Estrogen Receptor Modulators / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008593:Menopause; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use; D012735:Sexual Dysfunction, Physiological / Q000188:drug therapy*; D014621:Vagina / Q000098:blood supply / Q000473:pathology; D014661:Vasoconstriction / Q000502:physiology
D020847:Estrogen Receptor Modulators; D004967:Estrogens; D009652:Norpregnenes; D004958:Estradiol; C027385:tibolone