Prevalence of aac(6')-Ib-cr encoding a ciprofloxacin-modifying enzyme among Enterobacteriaceae blood isolates in Korea.
The aac(6')-Ib gene was detected in 86 of 555 (15.5%) Enterobacteriaceae isolates. Among these 86 aac(6')-Ib-positive isolates, 19 (22.0%) were positive for aac(6')-Ib-cr: 4 of 31 (12.9%) Enterobacter spp., 7 of 13 (53.8%) Escherichia coli isolates, and 8 of 42 (19.0%) Klebsiella pneumoniae isolates. There was a strong association between aac(6')-Ib-cr and OXA-1 and CTX-M-1 group beta-lactamase genes. One aac(6')-Ib-positive K. pneumoniae isolate carried both aac(6')-Ib-cr and qnrS.
Kim
Eun Sil
ES
Division of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea.
Jeong
Jin-Yong
JY
Jun
Jae-Bum
JB
Choi
Sang-Ho
SH
Lee
Sang-Oh
SO
Kim
Mi-Na
MN
Woo
Jun Hee
JH
Kim
Yang Soo
YS
D000123:Acetyltransferases / Q000235:genetics*; D002939:Ciprofloxacin / Q000378:metabolism* / Q000494:pharmacology; D003227:Conjugation, Genetic; D004755:Enterobacteriaceae / Q000187:drug effects / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D001618:beta-Lactamases / Q000235:genetics
D002939:Ciprofloxacin; D000123:Acetyltransferases; C019681:aminoglycoside acetyltransferase; D001618:beta-Lactamases