[Experimental study regarding the ureteral cicatrization pattern in rabbit].
This study aimed to elaborate an experimental model for ureteral cicatrization following surgical lesion, with direct involvement in urological therapy.


METHODS
The study was realized on a group of 9 female rabbits on which we have performed ureteral surgery. First surgical event consisted in partial cut of the left ureter following transperitoneal approach, ureteral stent insertion and the suture of the ureteral wound. The second surgical event has accomplished the harvesting of the ureteral fragment during cicatrisation process and was performed at various times from the first surgical event, accordingly at 1, 2, 3...6 days--on different rabbits. 3 rabbits composed the witness group. Fragments were fixed in formol 4%, and histologically stained with hematoxilin-eosin and van Gieson.


RESULTS
In the first two days we have observed an obvious inflammatory process on the postoperative ureteral scar. In days 3 and 4, the limited fibrosis appeared in the 2nd day engaged a peak in the 4th day when appeared a sketch of ureteral lumen constriction. In the 5th and 6th day the fibrosis process underwent a moderate resolution, simultaneously with a local diffuse congestion, marker for the remodeling processes of the connective matrix.


CONCLUSIONS
Animal cicatrisation model follows the same pattern as in human but at different timing so as extrapolation requires considering these facts.
Pintilie
R A
RA
Disciplina de Obstetrică-Ginecologie, Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
Grigorovici
Mirela
M
D000818:Animals; D002921:Cicatrix / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011817:Rabbits; D013997:Time Factors; D014513:Ureter / Q000293:injuries*; D014945:Wound Healing