title: Incidental detection by [11C]choline PET/CT of meningiomas in prostate cancer patients.
abstract: OBJECTIVE
  Anti-androgenic hormonal therapy in prostate cancer patients with concomitant meningioma may result in tumor growth and development of neurological symptoms. Positron emission tomography/computed tomography (PET/CT) with [11C]choline is used for restaging prostate cancer patients with biochemical failure. In vitro and in vivo data support altered choline metabolism in meningiomas.
  
  
  METHODS
  During a retrospective study in prostate cancer patients with biochemical failure referred to our institution between November 2004 and January 2007, encephalic focal uptake of [11C]choline was incidentally noted in 4 patients, 2 of which had been taking luteinizing hormone-releasing hormone analogs.
  
  
  RESULTS
  Subsequent to the incidental finding, one patient underwent surgical removal of the meningioma; strict neuroradiological follow-up was planned for the 3 other patients.
  
  
  CONCLUSIONS
  We suggest that in prostate cancer patients candidate for anti-androgenic therapy the whole body [11C]choline PET/CT scan should include the whole skull to check for the possible presence of meningiomas. This could help to identify patients at risk for the development of neurological symptoms during anti-androgenic therapy and help the referring urologist in the clinical management of these patients.
authors.affiliation: Department of Nuclear Medicine, San Gerardo Hospital, Monza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Fallanca
authors.forename: G
authors.initials: G
authors.lastname: Giovacchini
authors.forename: M
authors.initials: M
authors.lastname: Picchio
authors.forename: V
authors.initials: V
authors.lastname: Bettinardi
authors.forename: C
authors.initials: C
authors.lastname: Messa
authors.forename: F
authors.initials: F
authors.lastname: Fazio
mesh_terms: D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis*; D005260:Female; D006801:Humans; D033162:Incidental Findings; D008297:Male; D008577:Meningeal Neoplasms / Q000175:diagnosis*; D008579:Meningioma / Q000175:diagnosis*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis*; D049268:Positron-Emission Tomography / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals