title: Impact of liver cirrhosis on mortality in patients with community-acquired bacteremia.
abstract: Few studies have analyzed the impact of liver cirrhosis, a clinically significant comorbid medical condition, on the mortality of patients with community-acquired bacteremia. We conducted an observational study of 839 consecutive community-acquired bacteremia patients who were hospitalized through the emergency department (ED). We compared the 30-day mortality of bacteremia patients with and without liver cirrhosis using Cox proportional hazards regression. The probability of survival at day 30 was significantly different for the cirrhotic and noncirrhotic groups (53% versus 82%, respectively; P < 0.001 by the log-rank test). Multivariate analysis indicated that liver cirrhosis was associated with an increased risk of short-term mortality (hazard ratio, 2.0; 95% confidence interval, 1.1-3.5), as well as age, higher comorbidity index, and markers obtained from clinical presentation at ED. In conclusion, in addition to the effects from other prognostic factors, liver cirrhosis has a significant impact on the mortality of patients with community-acquired bacteremia.
authors.affiliation: Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
authors.forename: Shey-Ying
authors.initials: SY
authors.lastname: Chen
authors.forename: Chu-Lin
authors.initials: CL
authors.lastname: Tsai
authors.forename: Chien-Hao
authors.initials: CH
authors.lastname: Lin
authors.forename: Chien-Chang
authors.initials: CC
authors.lastname: Lee
authors.forename: Wen-Chu
authors.initials: WC
authors.lastname: Chiang
authors.forename: Jiun-Ling
authors.initials: JL
authors.lastname: Wang
authors.forename: Matthew Huei-Ming
authors.initials: MH
authors.lastname: Ma
authors.forename: Shyr-Chyr
authors.initials: SC
authors.lastname: Chen
authors.forename: Wen-Jone
authors.initials: WJ
authors.lastname: Chen
authors.forename: Shan-Chwen
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000367:Age Factors; D000368:Aged; D016470:Bacteremia / Q000150:complications* / Q000401:mortality*; D017714:Community-Acquired Infections / Q000150:complications* / Q000401:mortality*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors