Formulation development of oral controlled release tablets of hydralazine: optimization of drug release and bioadhesive characteristics.
The current study involves development of oral bioadhesive hydrophilic matrices of hydralazine hydrochloride, and optimization of their in vitro drug release profile and ex vivo bioadhesion against porcine gastric mucosa. A 32 central composite design was employed to systematically optimize the drug delivery formulations containing two polymers, viz., carbomer and hydroxypropyl methyl cellulose. Response surface plots were drawn and optimum formulations were selected by brute force searches. Validation of the formulation optimization study indicated a very high degree of prognostic ability. The study successfully undertook the development of an optimized once-a-day formulation of hydralazine with excellent bioadhesive and controlled release characteristics.
Singh
Bhupinder
B
University Institute of Pharmaceutical Sciences (UGC Centre for Advanced Studies), Panjab University, Chandigarh-160014, India. bsbhoop@yahoo.com
Pahuja
Sonia
S
Kapil
Rishi
R
Ahuja
Naveen
N
D000180:Acrylic Resins / Q000737:chemistry; D000268:Adhesiveness; D000284:Administration, Oral; D000818:Animals; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D005753:Gastric Mucosa / Q000378:metabolism; D006830:Hydralazine / Q000008:administration & dosage* / Q000737:chemistry; D065347:Hypromellose Derivatives; D066298:In Vitro Techniques; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D013552:Swine; D013607:Tablets; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000737:chemistry
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D013607:Tablets; D014665:Vasodilator Agents; C479038:carbomer; D006830:Hydralazine; D065347:Hypromellose Derivatives; D008747:Methylcellulose