Harness the power: new insights into the inhibition of YAP/Yorkie.
YAP/Yorkie (Yki) is a transcriptional coactivator that controls organ size; dysregulation causes tumorigenesis by stimulating cell proliferation and inhibiting apoptosis. The Hippo pathway restrains YAP/Yki activity, but it remains unclear how cellular regulation at the plasma membrane influences the Hippo-YAP/Yki pathway. Two papers in this issue on Developmental Cell, by Badouel et al. and Nishioka et al., address this question.
Zhao
Bin
B
Department of Pharmacology and Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093-0815, USA.
Lei
Qun-Ying
QY
Guan
Kun-Liang
KL
D000818:Animals; D051017:Apoptosis Regulatory Proteins / Q000037:antagonists & inhibitors*; D004330:Drosophila; D029721:Drosophila Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008322:Mammals; D008954:Models, Biological; D009687:Nuclear Proteins / Q000037:antagonists & inhibitors*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D015398:Signal Transduction; D015534:Trans-Activators / Q000037:antagonists & inhibitors*; D000091102:YAP-Signaling Proteins; D000099317:Hippo Kinases
D051017:Apoptosis Regulatory Proteins; D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; D015534:Trans-Activators; D000091102:YAP-Signaling Proteins; C503814:Yki protein, Drosophila; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases