Cerebrospinal fluid levels of iodothyronines and nerve growth factor in patients with multiple sclerosis and neuromyelitis optica.
OBJECTIVE
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the human central nervous system (CNS) and a major cause of neurological disability among adults in North America and Europe. Neuromyelitis optica (NMO) is a very severe disease of inflammatory demyelination located in the optic chiasm, nerves and the spinal cord. The aim of this study is to assess thyroid hormone (TH) and nerve growth factor (NGF) levels in cerebrospinal fluid (CSF) of MS, NMO patients and controls, and investigate whether there is any correlation between TH and NGF levels in the CSF.


METHODS
38 relapsing-remitting multiple sclerosis (RRMS), 10 NMO and 19 controls were investigated whether there was any correlation between TH and NGF levels in the CSF.


RESULTS
MS and NMO patients exhibited significantly higher CSF NGF (respectively P<0.05, P<0.05), TT4 levels (P<0.001) and higher TT4/ rT3 ratio (respectively P<0.01, P<0.01) compared with the controls. Significant correlation was found between CSF NGF levels and CSF rT3 levels or TT4/ rT3 ratio in controls (respectively P<0.01, P<0.05). EDSS was significantly correlated with CSF rT3 levels and TT4/ rT3 ratio in MS patients (respectively P<0.05, P<0.001).


CONCLUSIONS
These results indicate that an abnormal thyroid hormone may exist within the brain in the patients with MS. CSF rT3 levels and TT4/ rT3 ratio could be regarded as useful markers of underlying disease activity.
Jiang
Ying
Y
Department of Neurology, the Third Affiliated Hospital of Sun Yat-Sen University, 600# Tianhe Road, GuangZhou, 510630 Guangdong Province, China.
Yang
Yu
Y
Zhang
Bin
B
Peng
Fuhua
F
Bao
Jian
J
Hu
Xueqiang
X
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000473:pathology; D020932:Nerve Growth Factor / Q000134:cerebrospinal fluid*; D009471:Neuromyelitis Optica / Q000134:cerebrospinal fluid* / Q000473:pathology; D012107:Research Design; D012720:Severity of Illness Index; D013963:Thyroid Hormones / Q000134:cerebrospinal fluid; D013970:Thyronines / Q000134:cerebrospinal fluid*; D055815:Young Adult
D013963:Thyroid Hormones; D013970:Thyronines; D020932:Nerve Growth Factor