[Effects of influenza vaccination on the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients: a cohort study].
OBJECTIVE
To determine the incidence of immunologic change in the percentage of CD4+ T lymphocytes in HIV 1/2 positive patients in the first quarter after influenza vaccination (P-CIR) and to compare the demographic and clinical characteristics associated with this change.


METHODS
We studied 105 patients with HIV/AIDS in a retrospective hospital cohort between 2001-2006. P-CIR was considered as a decrease of >3% in the prevaccination CD4+ percentage. Crude and adjusted OR (sex, age, antiretroviral therapy, clinical stability, prevaccination viremia and prevaccination total CD4) were evaluated by logistic regression (95%CI).


RESULTS
The incidence of P-CIR was 33.3%. P-CIR was persistent in 31.4% for 7 months after vaccination regardless of high prevaccination viremia. No association was found between demographic and clinical variables and P-CIR [crude OR: 0.90 (0.17-4.8); adjusted OR: 1.09 (0.17-6.8)].


CONCLUSIONS
The results showed that the immunological change after vaccination was not inconsiderable. However, this change was mainly transient.
Barrionuevo Rosas
Leslie
L
Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, España.
Masuet Aumatell
Cristina
C
Ramon Torrell
Josep M
JM
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology*; D015497:HIV-1; D015498:HIV-2; D006785:Hospitals, University; D006801:Humans; D007252:Influenza Vaccines / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology; D014611:Vaccination; D019562:Viral Load
D019380:Anti-HIV Agents; D007252:Influenza Vaccines