Acromegaly accompanied by Turner syndrome with 47,XXX/45,X/46,XX mosaicism.
A 33-year-old woman was hospitalized for examination of edematous laryngopharynx. She was acromegalic. A pituitary adenoma with elevated serum levels of growth hormone (GH) and insulin-like growth factor-I (IGF-I) was detected, indicating acromegaly caused by GH-secreting pituitary adenoma. Multiple pigmented nevi were also noted without overt short stature and cubitus valgus. Chromosome analysis revealed that she had contracted Turner syndrome with 47,XXX/45,X/46,XX mosaicism. Transsphenoidal resection of the tumor decreased serum GH and IGF-I levels, but the edema was not improved. Both premature ovarian failure and hypertension appeared after surgery. This case may indicate the important relationships between GH/IGF-I and Turner syndrome.
Yamazaki
Masanori
M
Department of Aging Medicine and Geriatrics, Division of Medicine, Institute on Aging and Adaptation, Shinshu University Graduate School, Matsumoto. macha@shinshu-u.ac.jp
Sato
Ai
A
Nishio
Shin-ichi
S
Takeda
Teiji
T
Miyamoto
Takahide
T
Katai
Miyuki
M
Hashizume
Kiyoshi
K
D000172:Acromegaly / Q000209:etiology / Q000235:genetics*; D000236:Adenoma / Q000097:blood / Q000150:complications / Q000175:diagnosis; D000328:Adult; D041321:Chromosomes, Human, X / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D009030:Mosaicism; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis; D014424:Turner Syndrome / Q000150:complications / Q000235:genetics*
D013006:Growth Hormone