title: Polycythaemia vera in Nigeria.
abstract: BACKGROUND
  There is a paucity of reports on polycythaemia vera (PV) in Nigeria. The aim of this review is to present the pattern of clinical presentation, method of diagnosis, therapeutic options and treatment outcome in the face of limited facilities.
  
  
  METHODS
  Case notes of patients with confirmed diagnosis of PV managed at the Obafemi Awolowo University Teaching Hospitals Complex (OAUTHC), Ile-Ife, Nigeria from 1997 to 2006, were reviewed for clinical and laboratory parameters. The relative proportion of PV to other cases of haematologic cancers seen within the same period was determined.
  
  
  RESULTS
  Seven patients, 5 males and 2 females, aged 42-70 years (median, 53 years) were studied. All the patients were symptomatic at diagnosis with the majority presenting with headaches, visual disturbances, and tinnitus. Clinical signs include conjuctival suffusion in all the patients; splenomegaly, hepatomegaly and hypertension in 3 patients (42.8%). Pruritus was uncommon (14.3%). One patient (14.3%) presented with fatal cerebrovacscular accident on admission. The average follow up period was 39.9 months, and 2 patients (28.6%) were followed up for more than 7years. Therapy consisted mainly of regular phlebotomy and low dose aspirin for suppression of thromboxane synthesis and control of thrombocytosis and erythomelalgia. PV accounts for just 0.03% of all the haematologic cancers seen.
  
  
  CONCLUSIONS
  PV has a low incidence in our population and affects significantly the middle age persons. The clinical presentation consisted of headaches, visual disturbance, hypertension, and organomegaly. Treatment outcome are not different from those previously reported. The need for life-long follow up must be emphasised to patients at diagnosis.
authors.affiliation: Department of Haematology and Blood Transfusion, OAUTHC, Ile-Ife, Nigeria. E-mail: bolarinwaraa@yahoo.co.uk.
authors.forename: R A A
authors.initials: RA
authors.lastname: Bolarinwa
authors.forename: M A
authors.initials: MA
authors.lastname: Durosinmi
mesh_terms: D006801:Humans; D015994:Incidence; D009549:Nigeria / Q000453:epidemiology; D011087:Polycythemia Vera; D012189:Retrospective Studies; D016896:Treatment Outcome