Vitamin-d-receptor genotypes and bone-mineral density in postmenopausal women: interaction with physical activity.
The current study investigated the association between vitamin-D-receptor (VDR) genotypes with bone-mineral density (BMD) and its interaction with physical activity level (PAL). Individuals in a sample of 192 volunteers (67.84 +/- 5.23 years) underwent BMD evaluation and were genotyped for VDR ApaI, BsmI, FokI, and TaqI polymorphisms. Haplotypes were reconstructed through expectation-maximization algorithm, and regression-based haplotype-specific association tests were performed with studied phenotypes. None of the polymorphisms were associated with BMD at any site; however, haplotype was associated with femoral-neck and Ward's-triangle BMD. Interaction between PAL and VDR genotypes was significant for the FokI polymorphism at femoral-neck and Ward's-triangle BMD. The FokI T/T genotype was associated with higher BMD in active women. It was concluded that VDR haplotypes, but not genotypes, are associated with femoral-neck and Ward's-triangle BMD in postmenopausal women. Moreover, the results suggest that VDR FokI polymorphism might be a potential determinant of BMD response to physical activity.
Gentil
Paulo
P
Graduate Program in Physical Education, the College of Physical Education, University of Brasilia, Brazil.
de Lima Lins
Tulio Cesar
TC
Lima
Ricardo Moreno
RM
de Abreu
Breno Silva
BS
Grattapaglia
Dario
D
Bottaro
Martim
M
de Oliveira
Ricardo Jaco
RJ
Pereira
Rinaldo Wellerson
RW
D015502:Absorptiometry, Photon; D000368:Aged; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics* / Q000502:physiology; D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008159:Lumbar Vertebrae; D009043:Motor Activity / Q000235:genetics*; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics* / Q000502:physiology; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D011795:Surveys and Questionnaires
D018167:Receptors, Calcitriol