title: Common genetic variants of the vitamin D binding protein (DBP) predict differences in response of serum 25-hydroxyvitamin D [25(OH)D] to vitamin D supplementation.
abstract: BACKGROUND
  To determine the effect of vitamin D binding protein (DBP) genotypes on 25-hydroxyvitamin D [25(OH)D] changes with vitamin D supplements, we studied 98 adults receiving 600 or 4000 IU/d vitamin D(3) for one year.
  
  
  METHODS
  The DBP functional variant, T436K, was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Mean 25(OH)D increases were 97% for TT (n=48), 151% for TK (n=31) and 307% (n=6) for KK genotypes (p=.004).
  
  
  CONCLUSIONS
  As with baseline 25(OH)D, T436K genotype predicts 25(OH)D changes after long-term vitamin D supplementation.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada M5G 1L5.
authors.forename: Lei
authors.initials: L
authors.lastname: Fu
authors.forename: Francisco
authors.initials: F
authors.lastname: Yun
authors.forename: Marko
authors.initials: M
authors.lastname: Oczak
authors.forename: Betty Y L
authors.initials: BY
authors.lastname: Wong
authors.forename: Reinhold
authors.initials: R
authors.lastname: Vieth
authors.forename: David E C
authors.initials: DE
authors.lastname: Cole
mesh_terms: D019587:Dietary Supplements; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014809:Vitamin D-Binding Protein / Q000235:genetics*
chemical_list: D014809:Vitamin D-Binding Protein; D014807:Vitamin D; C104450:25-hydroxyvitamin D