title: Whole-body MR angiography with body coil acquisition at 3 T in patients with peripheral arterial disease using the contrast agent gadofosveset trisodium.
abstract: OBJECTIVE
  Whole-body magnetic resonance angiography (WB-MRA) at 3 T with body coil acquisition has not previously been investigated. In this study, WB-MRA was performed in this manner using the blood pool contrast agent gadofosveset trisodium.
  
  
  METHODS
  Eleven consecutive patients (five men, six women) with symptomatic peripheral arterial disease (two with critical limb ischemia, nine with claudication) were examined. Conventional digital subtraction angiography (DSA) of the aorta and the inflow and runoff arteries was used as the reference method. WB-MRA was performed using four slightly overlapping stations covering the arteries from the neck to the ankles. The arterial system was divided into 42 segments that were analyzed for the presence of significant arterial disease (> or =50% luminal narrowing or occlusion) by two blinded observers.
  
  
  RESULTS
  Sensitivities for detecting a significant arterial lesion with WB-MRA using gadofosveset as the contrast agent were 0.66 (95% confidence interval [CI], 0.49-0.79) and 0.68 (95% CI, 0.52-0.81) for the two observers. Specificities were 0.82 (95% CI, 0.74-0.88) and 0.93 (95% CI, 0.87-0.96), respectively. Intermodality agreement between WB-MRA and DSA was moderate to good, with overall kappa values of 0.44 (95% CI, 0.29-0.59) and 0.63 (95% CI, 0.5-0.77) for the two observers. Interobserver agreement for WB-MRA was good, at kappa = 0.60 (95% CI, 0.50-0.71).
  
  
  CONCLUSIONS
  WB-MRA at 3 T with body coil acquisition in patients with peripheral arterial disease showed good reproducibility but only moderate to good agreement with DSA. Further assessment of the method's clinical application is warranted.
authors.affiliation: Department of Radiology, Copenhagen University Hospital Herlev, Herlev Ringvej 75, DK-2730 Copenhagen, Denmark. yujwni01@heh.regionh.dk
authors.forename: Yousef W
authors.initials: YW
authors.lastname: Nielsen
authors.forename: Jonas P
authors.initials: JP
authors.lastname: Eiberg
authors.forename: Vibeke B
authors.initials: VB
authors.lastname: Løgager
authors.forename: Marc A
authors.initials: MA
authors.lastname: Hansen
authors.forename: Torben V
authors.initials: TV
authors.lastname: Schroeder
authors.forename: Henrik S
authors.initials: HS
authors.lastname: Thomsen
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D005682:Gadolinium; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds; D016491:Peripheral Vascular Diseases / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D051598:Whole Body Imaging / Q000379:methods*
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D005682:Gadolinium; C109932:gadofosveset trisodium