title: Structural requirements of the Pseudomonas quinolone signal for membrane vesicle stimulation.
abstract: Pseudomonas aeruginosa produces the quorum signal 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal), which is important for stimulating outer membrane vesicle (MV) formation. Here we describe the importance of the 3-hydroxyl and 2-alkyl chain for MV production and the length of the 2-alkyl chain for association with MVs.
authors.affiliation: Section of Molecular Genetics and Microbiology and Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: Lauren
authors.initials: L
authors.lastname: Mashburn-Warren
authors.forename: Jörg
authors.initials: J
authors.lastname: Howe
authors.forename: Klaus
authors.initials: K
authors.lastname: Brandenburg
authors.forename: Marvin
authors.initials: M
authors.lastname: Whiteley
mesh_terms: D008070:Lipopolysaccharides / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry* / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: C407944:2-heptyl-3-hydroxy-4-quinolone; D008070:Lipopolysaccharides; D015363:Quinolones