title: Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus.
abstract: Lead is a well-known toxin in the environment that causes severe damage to the nervous system. Gastrodin is the main bioactive component of Tian ma ( GASTRODIA ELATA Bl.), which is a traditional herbal medicine widely used in eastern Asia. Increasing lines of evidence show that gastrodin has diverse effects, especially neuroprotective effects. In the present study, we investigated whether gastrodin supplementation can rescue impairments of synaptic plasticity produced by developmental lead exposure. We examined three electrophysiological parameters of synaptic plasticity: input/output (I/O) function, paired-pulse facilitation (PPF), and long-term potentiation (LTP) of field excitatory postsynaptic potential (fEPSP) in the hippocampal CA1 region of rats on postnatal day 22 (P22). Our results showed that lead exposure significantly impaired synaptic plasticity in the hippocampal CA1 region and that gastrodin can effectively rescue these lead-induced impairments. Therefore, gastrodin may have potential therapeutic value for lead-induced impairments during human developmental stages.
authors.affiliation: Department of Neurobiology and Biophysics, School of Life Sciences, University of Science and Technology of China, Hefei, Anhui, P. R. China.
authors.forename: Wu
authors.initials: W
authors.lastname: Yong
authors.forename: Tai-Ran
authors.initials: TR
authors.lastname: Xing
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Liang
authors.initials: L
authors.lastname: Chen
authors.forename: Pu
authors.initials: P
authors.lastname: Hu
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Li
authors.forename: Hui-Li
authors.initials: HL
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Ju-Tao
authors.initials: JT
authors.lastname: Chen
authors.forename: Di-Yun
authors.initials: DY
authors.lastname: Ruan
mesh_terms: D000818:Animals; D001592:Benzyl Alcohols / Q000494:pharmacology*; D019706:Excitatory Postsynaptic Potentials; D005260:Female; D005960:Glucosides / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects*
chemical_list: D001592:Benzyl Alcohols; D005960:Glucosides; C045345:gastrodin