title: A randomized trial to investigate the effects of functional electrical stimulation and therapeutic exercise on walking performance for people with multiple sclerosis.
abstract: BACKGROUND
  Functional electrical stimulation (FES), is a means of producing a contraction in a paralyzed or weak muscle to enable function through electrical excitation of the innervating nerve.
  
  
  OBJECTIVE
  This two-group randomized trial assessed the effects of single channel common peroneal nerve stimulation on objective aspects of gait relative to exercise therapy for people with secondary progressive multiple sclerosis (SPMS).
  
  
  METHODS
  Forty-four people with a diagnosis of SPMS and unilateral dropped foot completed the trial. Twenty patients were randomly allocated to a group receiving FES and the remaining 24 to a group receiving a physiotherapy home exercise program for a period of 18 weeks.
  
  
  RESULTS
  The exercise group showed a statistically significant increase in 10 m walking speed and distance walked in 3 min, relative to the FES group who showed no significant change in walking performance without stimulation. At each stage of the trial, the FES group performed to a significantly higher level with FES than without for the same outcome measures.
  
  
  CONCLUSIONS
  Exercise may provide a greater training effect on walking speed and endurance than FES for people with SPMS. FES may provide an orthotic benefit when outcome is measured using the same parameters. More research is required to investigate the combined therapeutic effects of FES and exercise for this patient group.
authors.affiliation: The National Clinical FES Centre, Department of Clinical Sciences and Biomedical Engineering, Salisbury District Hospital, Salisbury, Wiltshire SP2 8BJ, UK.
authors.forename: C L
authors.initials: CL
authors.lastname: Barrett
authors.forename: G E
authors.initials: GE
authors.lastname: Mann
authors.forename: P N
authors.initials: PN
authors.lastname: Taylor
authors.forename: P
authors.initials: P
authors.lastname: Strike
mesh_terms: D000328:Adult; D000368:Aged; D004599:Electric Stimulation Therapy; D005081:Exercise Therapy; D005260:Female; D005684:Gait; D020233:Gait Disorders, Neurologic / Q000534:rehabilitation / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D020528:Multiple Sclerosis, Chronic Progressive / Q000534:rehabilitation* / Q000628:therapy*; D010543:Peroneal Nerve / Q000502:physiology; D026741:Physical Therapy Modalities; D016896:Treatment Outcome; D016138:Walking