[Successful treatment of life-threatening Panton-Valentine leucocidin positive Staphylococcus aureus pneumonia with antibiotics and immunoglobulins targeting the toxin production].
We report a patient who presented a severe Panton-Valentine-secreting methicillin-susceptible Staphylococcus aureus pneumonia with threatening multi-organ failure including acute respiratory distress syndrome, cardiac failure, renal failure and disseminated intravascular coagulation. Clinical and biological disease course using empiric therapy with treatment directed against toxin production (linezolid, clindamycin and intravenous immunoglobulins) was found to be quickly effective.
Libert
N
N
Service d'anesthésie et réanimation, hôpital d'instruction-des-armées du Val-de-Grâce, Paris, France. nicolaslibert@free.fr
Borne
M
M
Janvier
F
F
Batjom
E
E
Cirodde
A
A
Nizou
J-Y
JY
Brinquin
L
L
D000081:Acetamides / Q000627:therapeutic use; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000096:biosynthesis*; D002981:Clindamycin / Q000627:therapeutic use; D005098:Exotoxins / Q000096:biosynthesis*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007956:Leukocidins / Q000096:biosynthesis*; D000069349:Linezolid; D008297:Male; D009102:Multiple Organ Failure / Q000188:drug therapy / Q000209:etiology; D023303:Oxazolidinones / Q000627:therapeutic use; D018410:Pneumonia, Bacterial / Q000188:drug therapy*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy / Q000209:etiology; D013203:Staphylococcal Infections / Q000188:drug therapy*
D000081:Acetamides; D000890:Anti-Infective Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D016756:Immunoglobulins, Intravenous; D007956:Leukocidins; D023303:Oxazolidinones; C078284:Panton-Valentine leukocidin; D002981:Clindamycin; D000069349:Linezolid