title: Cisplatin-based chemotherapy for pulmonary metastasized germ cell tumors of the testis--be aware of acute respiratory distress syndrome.
abstract: BACKGROUND
  Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of a 'tumorassociated' acute respiratory distress syndrome (ARDS) has been hypothesized.
  
  
  METHODS
  We report the clinical course of a 19-year-old patient who rapidly developed fatal ARDS during the first cycle of chemotherapy using the PEI regimen (cisplatin, etoposide and ifosfamide) for a metastasized (lung, liver, lymph nodes) germ cell tumor of the testis.
  
  
  CONCLUSIONS
  Further clinical research in order to better define risk factors for developing ARDS in this patient population as well as novel strategies for the prevention and treatment of ARDS in those patients are necessary.
authors.affiliation: Department of Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Germany. stefan.boeck@med.uni-muenchen.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Boeck
authors.forename: Klaus H
authors.initials: KH
authors.lastname: Metzeler
authors.forename: Andreas
authors.initials: A
authors.lastname: Hausmann
authors.forename: Anja
authors.initials: A
authors.lastname: Baumann
authors.forename: Eike
authors.initials: E
authors.lastname: Gallmeier
authors.forename: Klaus G
authors.initials: KG
authors.lastname: Parhofer
authors.forename: Hans-Joachim
authors.initials: HJ
authors.lastname: Stemmler
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects*; D005870:Giant Cell Tumors / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000556:secondary*; D008297:Male; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000517:prevention & control; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin