title: Long-term quality of life evaluation after laser microsurgery with or without adjuvant radiotherapy for laryngeal carcinoma.
abstract: OBJECTIVE
  We evaluated long-term quality of life of patients successfully treated with either laser-assisted microsurgery alone or combined with adjuvant radiotherapy for laryngeal carcinoma.
  
  
  METHODS
  The study included 53 patients who were treated by laser surgery and 16 patients who were treated by laser surgery combined with adjuvant radiotherapy. Quality of life was evaluated with two validated questionnaires: the global EORTC QLQ-C30 and the head and neck specific EORTC QLQ-H&N35. The mean follow-up was 59 months (range 10 to 111 months).
  
  
  RESULTS
  Patients receiving adjuvant radiotherapy showed a significantly lower level of global health status. Surprisingly, the two treatment groups showed close similarities with respect to symptoms specific to the head and neck region. The most frequent complaints were coughing and speech problems in both groups. On the other hand, patients with a follow-up duration of more than or less than five years did not differ significantly with regard to the global health status.
  
  
  CONCLUSIONS
  Adjuvant radiotherapy must be selectively utilized in patients treated with laser surgery for laryngeal carcinoma.
authors.affiliation: Department of Otolaryngology, Ruhr-University Bochum, St. Elisabeth Hospital, Bochum, Germany.
authors.forename: Amir
authors.initials: A
authors.lastname: Minovi
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ural
authors.forename: Chantal
authors.initials: C
authors.lastname: Nowak
authors.forename: Marc
authors.initials: M
authors.lastname: Pearson
authors.forename: Stefan
authors.initials: S
authors.lastname: Dazert
authors.forename: Dominik
authors.initials: D
authors.lastname: Brors
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000532:radiotherapy* / Q000601:surgery*; D053685:Laser Therapy; D008297:Male; D018613:Microscopy, Confocal / Q000295:instrumentation / Q000379:methods; D008866:Microsurgery; D008875:Middle Aged; D011446:Prospective Studies; D011594:Psychometrics; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome