[Clinical significance of anti-D IgG screening and titer detection in 286 RhD negative pregnant women].
OBJECTIVE
Anti-D IgG in RhD negative pregnant women is the main antibody of Rh-induced hemolytic disease of newborn (HDN). The study aimed to investigate the clinical significance of anti-D IgG screening and titer detection in RhD negative pregnant women.


METHODS
Sera of 286 RhD negative pregnant women were collected. Microtube column indirect antiglobulin test was used to screen and identify anti-D IgG. The indirect antiglobulin test was used to test the titer of anti-D IgG.


RESULTS
Anti-D IgG was identified in 21 cases (7.3%). The titer of anti-D showed an increasing trend with pregnancy progresses. The clinical outcomes of 12 fetuses (newborns) from positive anti-D pregnant women were observed. Two cases died in utero, 2 cases did not show abnormality and 8 cases had hemolysis. The 8 cases with hemolysis were treated with exchange transfusion or blood transfusion, and they had a good prognosis.


CONCLUSIONS
The screening and titer detection of anti-D IgG in RhD negative pregnant women are valuable in the prediction and treatment of HDN.
Liu
Kai-Liang
KL
Department of Blood Transfusion, Xiangya Hospital, Central South University, Changsha 410008, China. kailiang1974@163.com
Li
Ning
N
Li
Bi-Juan
BJ
Peng
Jin-Yan
JY
Shu
Xiang-Wu
XW
Yu
Yun-Ying
YY
D000017:ABO Blood-Group System / Q000276:immunology; D000328:Adult; D001787:Blood Group Incompatibility; D004899:Erythroblastosis, Fetal / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007518:Isoantibodies / Q000097:blood*; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000097:blood*; D018029:Rho(D) Immune Globulin
D000017:ABO Blood-Group System; D007074:Immunoglobulin G; D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin