Analgesia for cats after ovariohysterectomy with either buprenorphine or carprofen alone or in combination.
Eighty-four female cats undergoing ovariohysterectomy in a blinded, randomised, prospective clinical study were assigned to one of three groups of 28 to receive either 0.01 mg/kg buprenorphine (group B), 4 mg/kg carprofen (group C), or the same doses of both drugs (group BC). A dynamic and interactive visual analogue scale (DIVAS) from 0 to 100 mm, and a simple descriptive scale (SDS) from 0 to 4 were used to evaluate the cats' degree of analgesia and sedation for 24 hours postoperatively. There was no significant difference in the cats' sedation scores by SDS or DIVAS, and no difference in their pain scores by DIVAS. By SDS, the cats in group BC had significantly lower pain scores than the cats in group C (P<0.001) and group B (P<0.05). Nine of the cats in group B, nine in group C and five in group BC required rescue analgesia, and the cats in group C required rescue earlier than those in group B (P<0.05).
Steagall
P V M
PV
Department of Surgery and Veterinary Anaesthesiology, School of Veterinary Medicine and Animal Science, FMVZ, UNESP, Botucatu, SP, Brazil.
Taylor
P M
PM
Rodrigues
L C C
LC
Ferreira
T H
TH
Minto
B W
BW
Aguiar
A J A
AJ
D000701:Analgesics, Opioid / Q000008:administration & dosage*; D000768:Anesthesia, General / Q000662:veterinary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001522:Behavior, Animal / Q000187:drug effects; D002047:Buprenorphine / Q000008:administration & dosage*; D002227:Carbazoles / Q000008:administration & dosage*; D002415:Cats / Q000502:physiology / Q000601:surgery; D004359:Drug Therapy, Combination; D005260:Female; D007044:Hysterectomy / Q000379:methods / Q000662:veterinary; D010052:Ovariectomy / Q000379:methods / Q000662:veterinary; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000188:drug therapy / Q000662:veterinary*; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome
D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D002047:Buprenorphine; C007005:carprofen