title: The effect of bilio-pancreatic diversion on type 2 diabetes in patients with BMI <35 kg/m2.
abstract: OBJECTIVE
  To aim of the study was to investigate the effect of bilio-pancreatic diversion (BPD) on type 2 diabetes in patients with BMI <35 kg/m(2).
  
  
  METHODS
  OGTTs were performed and anthropometric data were compared between five diabetes patients (BMI 27-33 kg/m(2)) following BPD and seven diabetes patients after a low-energy diet. Insulin secretion was computed by C-peptide deconvolution. A euglycaemic-hyperinsulinaemic clamp was performed only in the BPD group and the M value measured.
  
  
  RESULTS
  One month after BPD, fasting and 2 h post-OGTT glycaemia decreased from 15.22 +/- 3.22 to 6.22 +/- 0.51 mmol/l (p = 0.043), while insulin sensitivity increased significantly. No significant changes were observed in the low-energy diet group. Insulin secretion did not differ significantly after either intervention. Diabetes amelioration (change in HbA(1c) level) was observed up to 18 months after BPD without pharmacological therapy.
  
  
  CONCLUSIONS
  BPD can achieve adequate control of type 2 diabetes also in patients with BMI <35 kg/m(2). The rapid postoperative remission of diabetes is primarily related to an improvement in insulin sensitivity.
authors.affiliation: Department of Internal Medicine, Catholic University, Rome, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Chiellini
authors.forename: F
authors.initials: F
authors.lastname: Rubino
authors.forename: M
authors.initials: M
authors.lastname: Castagneto
authors.forename: G
authors.initials: G
authors.lastname: Nanni
authors.forename: G
authors.initials: G
authors.lastname: Mingrone
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000601:surgery*; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008875:Middle Aged
chemical_list: D001786:Blood Glucose; D007328:Insulin