title: Expanding the repertoire of fluorescent calcium sensors.
abstract: Fluorescent indicators for calcium are incredibly powerful because they enable researchers to watch the movement of calcium ions in real time in living cells. The popular small molecule indicator Indo-1 has now been targeted to a defined location, namely, the nucleus of muscle cells, using SNAP-tag technology. This combination of a chemical probe with genetic targeting expands the available options for measuring local calcium events in cells.
authors.affiliation: Department of Chemistry and Biochemistry, University of Colorado, UCB 215, Boulder, Colorado 80309, USA. amy.palmer@colorado.edu
authors.forename: Amy E
authors.initials: AE
authors.lastname: Palmer
mesh_terms: D000818:Animals; D002118:Calcium / Q000032:analysis* / Q000378:metabolism; D002477:Cells / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D007211:Indoles / Q000737:chemistry; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000378:metabolism
chemical_list: D005456:Fluorescent Dyes; D007211:Indoles; C048960:indo-1; D002118:Calcium