The IL-16 gene polymorphisms and the risk of the systemic lupus erythematosus.
BACKGROUND
Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an important role in many inflammatory and autoimmune diseases. We determined the association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and rs4072111 C/T) and systemic lupus erythematosus (SLE).


METHODS
One hundred thirty-eight SLE patients and 199 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing assay.


RESULTS
In the SLE group, the individuals carrying the G allele of rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a significantly higher risk of SLE as compared with those carrying the T allele of rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455).


CONCLUSIONS
The IL-16 gene polymorphisms may be associated with the risk of SLE.
Xue
Hui
H
Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, PR China.
Gao
Linbo
L
Wu
Yongkang
Y
Fang
Wenliang
W
Wang
Lanlan
L
Li
Cui
C
Li
Yi
Y
Liang
Weibo
W
Zhang
Lin
L
D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic
D019410:Interleukin-16