Autologous adipose tissue as a new source of progenitor cells for therapeutic angiogenesis.
Therapeutic angiogenesis is an important means for salvaging tissues from severe ischemic diseases in patients with no option for other vascular interventions. A number of recent studies examined the possibilities of cell transplantation-mediated angiogenesis using autologous bone marrow mononuclear cells, CD34(+) cells, peripheral mononuclear cells, etc. Subcutaneous adipose tissue can be harvested by relatively easy technology. Recent studies indicate that adipose tissue contains progenitor cells that can give rise to several mesenchymal lineages. Moreover, these progenitor cells can release multiple angiogenic growth factors including vascular endothelial growth factor, hepatocyte growth factor, and chemokine stromal cell-derived factor. The combination of these biological properties of adipose-derived regenerative cells indicates that autologous adipose tissue will be a useful cell source for therapeutic angiogenesis.
Murohara
Toyoaki
T
Department of Cardiology, Nagoya University, Graduate School of Medicine, 65 Tsurumai, Showa-ku, Nagoya 466-8550, Japan. murohara@med.nagoya-u.ac.jp
D000273:Adipose Tissue / Q000166:cytology* / Q000637:transplantation; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D007511:Ischemia / Q000628:therapy; D018919:Neovascularization, Physiologic; D033581:Stem Cell Transplantation / Q000379:methods*; D013234:Stem Cells / Q000378:metabolism; D014182:Transplantation, Autologous; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
D042461:Vascular Endothelial Growth Factor A; D017228:Hepatocyte Growth Factor