The headache of a hyperactive calcium channel.
Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical glutamatergic synaptic transmission as an underlying mechanism for the susceptibility of cortical spreading depression initiation in migraine disorders.
Xue
Mingshan
M
Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Rosenmund
Christian
C
D000818:Animals; D015220:Calcium Channels / Q000235:genetics*; D006261:Headache / Q000235:genetics*; D009154:Mutation
D015220:Calcium Channels