A new dicoumarin and anticoagulant activity from Viola yedoensis Makino.
A new dicoumarin, named as dimeresculetin (1), together with another dicoumarin, euphorbetin (2) and esculetin (3) were isolated from the ethyl acetate extract of the dried whole plants of Viola yedoensis Makino. The structure of 1 was elucidated as 7-hydroxy-6-[(6,7-dihydroxy-2-oxo-2H-1-benzopyran-5-yl)oxy]-2H-1-benzopyran-2-one on the basis of extensive NMR, as well as the other spectral analysis. Compounds 1-3 exhibited anticoagulant activities with respect to activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT).
Zhou
Hai Yan
HY
Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, China. liliaceae@126.com
Hong
Jun Li
JL
Shu
Pan
P
Ni
Yue Juan
YJ
Qin
Min Jian
MJ
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D001728:Dicumarol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D010314:Partial Thromboplastin Time; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011517:Prothrombin Time; D011817:Rabbits; D013918:Thrombin Time; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032413:Viola / Q000737:chemistry*
C543238:7-hydroxy-6-((6,7-dihydroxy-2-oxo-2H-1-benzopyran-5-yl)oxy)-2H-1-benzopyran-2-one; D000925:Anticoagulants; D003374:Coumarins; D010936:Plant Extracts; D014468:Umbelliferones; C543239:euphorbetin; D001728:Dicumarol; D006493:Heparin; C007628:esculetin