title: Daily regulation of serum and urinary hepcidin is not influenced by submaximal cycling exercise in humans with normal iron metabolism.
abstract: Hepcidin and hemojuvelin (HJV) are two critical regulators of iron metabolism as indicated by the development of major iron overload associated to mutations in hepcidin and HJV genes. Hepcidin and HJV are highly expressed in liver and muscles, respectively. Intensive muscular exercise has been reported to modify serum iron parameters and to increase hepcidinuria. The present study aimed at evaluating the potential impact of low intensity muscle exercise on iron metabolism and on hepcidin, its key regulator. Fourteen normal volunteers underwent submaximal cycling-based exercise in a crossover design and various iron parameters, including serum and urinary hepcidin, were serially studied. The results demonstrated that submaximal ergocycle endurance exercise did not modulate hepcidin. This study also indicated that hepcidinuria did not show any daily variation whereas serum hepcidin did. The findings, by demonstrating that hepcidin concentrations are not influenced by submaximal cycling exercise, may have implications for hepcidin sampling in medical practice.
authors.affiliation: Liver Disease Unit, Inserm U-522, IFR 140, University Hospital Pontchaillou, Rennes, France. marie-berengere.troadec@path.utah.edu
authors.forename: Marie-Bérengère
authors.initials: MB
authors.lastname: Troadec
authors.forename: Fabrice
authors.initials: F
authors.lastname: Lainé
authors.forename: Vincent
authors.initials: V
authors.lastname: Daniel
authors.forename: Pierre
authors.initials: P
authors.lastname: Rochcongar
authors.forename: Martine
authors.initials: M
authors.lastname: Ropert
authors.forename: Florian
authors.initials: F
authors.lastname: Cabillic
authors.forename: Michèle
authors.initials: M
authors.lastname: Perrin
authors.forename: Jeff
authors.initials: J
authors.lastname: Morcet
authors.forename: Olivier
authors.initials: O
authors.lastname: Loréal
authors.forename: Gordana
authors.initials: G
authors.lastname: Olbina
authors.forename: Mark
authors.initials: M
authors.lastname: Westerman
authors.forename: Elizabeta
authors.initials: E
authors.lastname: Nemeth
authors.forename: Tomas
authors.initials: T
authors.lastname: Ganz
authors.forename: Pierre
authors.initials: P
authors.lastname: Brissot
mesh_terms: D023181:Antimicrobial Cationic Peptides / Q000097:blood* / Q000652:urine*; D015444:Exercise / Q000502:physiology*; D064451:Hepcidins; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000378:metabolism; D019266:Iron, Dietary; D053858:Metabolic Networks and Pathways
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D019266:Iron, Dietary; D007501:Iron