title: Perspectives on the Trypanosoma cruzi-host cell receptor interactions.
abstract: Chagas disease is caused by the parasite Trypanosoma cruzi. The critical initial event is the interaction of the trypomastigote form of the parasite with host receptors. This review highlights recent observations concerning these interactions. Some of the key receptors considered are those for thromboxane, bradykinin, and for the nerve growth factor TrKA. Other important receptors such as galectin-3, thrombospondin, and laminin are also discussed. Investigation into the molecular biology and cell biology of host receptors for T. cruzi may provide novel therapeutic targets.
authors.affiliation: Department of Microbial Pathogenesis and Immune Response, Meharry Medical College, Nashville, TN, USA. fvillalta@mmc.edu
authors.forename: Fernando
authors.initials: F
authors.lastname: Villalta
authors.forename: Julio
authors.initials: J
authors.lastname: Scharfstein
authors.forename: Anthony W
authors.initials: AW
authors.lastname: Ashton
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Tyler
authors.forename: Fangxia
authors.initials: F
authors.lastname: Guan
authors.forename: Shankar
authors.initials: S
authors.lastname: Mukherjee
authors.forename: Maria F
authors.initials: MF
authors.lastname: Lima
authors.forename: Sandra
authors.initials: S
authors.lastname: Alvarez
authors.forename: Louis M
authors.initials: LM
authors.lastname: Weiss
authors.forename: Huan
authors.initials: H
authors.lastname: Huang
authors.forename: Fabiana S
authors.initials: FS
authors.lastname: Machado
authors.forename: Herbert B
authors.initials: HB
authors.lastname: Tanowitz
mesh_terms: D000818:Animals; D014355:Chagas Disease / Q000469:parasitology*; D006790:Host-Parasite Interactions; D006801:Humans; D011956:Receptors, Cell Surface; D014349:Trypanosoma cruzi / Q000502:physiology*
chemical_list: D011956:Receptors, Cell Surface