title: Inhibitors of potassium channels KV1.3 and IK-1 as immunosuppressants.
abstract: New structural classes of K(V)1.3 and IK-1 ion channel blockers have been identified based on a virtual high throughput screening approach using a homology model of KcsA. These compounds display inhibitory effects on T-cell and/or keratinocyte proliferation and immunosuppressant activity within a DTH animal model.
authors.affiliation: 4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany.
authors.forename: Stefano
authors.initials: S
authors.lastname: Pegoraro
authors.forename: Martin
authors.initials: M
authors.lastname: Lang
authors.forename: Tobias
authors.initials: T
authors.lastname: Dreker
authors.forename: Jürgen
authors.initials: J
authors.lastname: Kraus
authors.forename: Svetlana
authors.initials: S
authors.lastname: Hamm
authors.forename: Cathal
authors.initials: C
authors.lastname: Meere
authors.forename: Juliane
authors.initials: J
authors.lastname: Feurle
authors.forename: Stefan
authors.initials: S
authors.lastname: Tasler
authors.forename: Sylvia
authors.initials: S
authors.lastname: Prütting
authors.forename: Zerrin
authors.initials: Z
authors.lastname: Kuras
authors.forename: Violeta
authors.initials: V
authors.lastname: Visan
authors.forename: Stephan
authors.initials: S
authors.lastname: Grissmer
mesh_terms: D000818:Animals; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004195:Disease Models, Animal; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000188:drug therapy / Q000378:metabolism; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology*; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000502:physiology; D015603:Keratinocytes / Q000187:drug effects / Q000502:physiology; D051664:Kv1.3 Potassium Channel / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000502:physiology; D018408:Patch-Clamp Techniques; D026902:Potassium Channel Blockers / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology*
chemical_list: D007166:Immunosuppressive Agents; D051660:Intermediate-Conductance Calcium-Activated Potassium Channels; C496923:KCNN4 protein, human; D051664:Kv1.3 Potassium Channel; D026902:Potassium Channel Blockers