Haliclonin A, a new macrocyclic diamide from the sponge Haliclona sp.
Haliclonin A (1), a macrocyclic diamide of a novel skeletal class, was isolated from the marine sponge Haliclona sp. collected from Korean waters. The structure of this compound was determined using a combination of spectroscopic and chemical analyses. The new compound exhibited moderate cytotoxicity and antibacterial activity against diverse microbial strains.
Jang
Kyoung Hwa
KH
Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Seoul 151-742, Korea.
Kang
Gyoung Won
GW
Jeon
Ju-Eun
JE
Lim
Chaemin
C
Lee
Hyi-Seung
HS
Sim
Chung J
CJ
Oh
Ki-Bong
KB
Shin
Jongheon
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003959:Diamines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D047129:Haliclona / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003959:Diamines; D047028:Macrocyclic Compounds; C540232:haliclonin A