Examination of the nicotine dependence (NICSNP) consortium findings in the Iowa adoption studies population.
BACKGROUND
Nicotine dependence results from a complex interplay of genetic and environmental factors. Over the past several years, a large number of studies have been performed to identify distinct gene loci containing genetic vulnerability to nicotine dependence. Two of the most prominent studies were conducted by the Collaborative Study of the Genetics of Nicotine Dependence (NICSNP) Consortium using both candidate gene and high-density association approaches.


METHODS
We attempted to confirm and extend the most significant findings from the high-density association study and the candidate gene study using the behavioral and genetic resources of the Iowa Adoption Studies, the largest case-control adoption study of substance use in the United States.


RESULTS
We found evidence that genetic variation at CHRNA1, CHRNA2, CHRNA7, and CHRNB1 alters susceptibility to nicotine dependence, but we did not replicate any of the most significant single nucleotide polymorphism associations from the NICSNP high-density association study.


CONCLUSIONS
Further examination of the NICSNP findings in other population samples is indicated.
Philibert
Robert A
RA
Department of Psychiatry and Neuroscience and Genetics Programs, University of Iowa, Rm 2-126 MEB, Iowa City, IA 52242, USA. robert-philibert@uiowa.edu
Todorov
Alexandre
A
Andersen
Allan
A
Hollenbeck
Nancy
N
Gunter
Tracy
T
Heath
Andrew
A
Madden
Pamela
P
D000328:Adult; D016022:Case-Control Studies; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007484:Iowa; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D020033:Protein Isoforms / Q000235:genetics; D011978:Receptors, Nicotinic / Q000235:genetics; D012044:Regression Analysis; D014029:Tobacco Use Disorder / Q000235:genetics*
D020033:Protein Isoforms; D011978:Receptors, Nicotinic