title: [Physical activity and prevention of Alzheimer's dementia: current evidence and feasibility of an interventional trial].
abstract: There is accumulating evidence from animal and epidemiologic studies that physical exercise is neuroprotective in healthy animals and humans and can prevent cognitive decline in chronic neurodegenerative processes like Alzheimer's dementia. However, data from well-designed interventional, randomized non-pharmacologic trials is lacking in contrast to other areas of medicine like prevention of hypertension, diabetes or the antipsychotic-associated metabolic syndrome. The demonstration of a potential positive effect of physical exercise on preventing dementia using a controlled study design would represent a significant progress in the prevention of dementia and public health, especially as long as other treatments for dementia prevention are lacking.
authors.affiliation: Psychiatrische und Psychotherapeutische Klinik, Universitätsklinikum Erlangen. markus.weih@uk-erlangen.de
authors.forename: M
authors.initials: M
authors.lastname: Weih
authors.forename: K
authors.initials: K
authors.lastname: Abu-Omar
authors.forename: H
authors.initials: H
authors.lastname: Esselmann
authors.forename: G
authors.initials: G
authors.lastname: Gelbrich
authors.forename: P
authors.initials: P
authors.lastname: Lewczuk
authors.forename: A
authors.initials: A
authors.lastname: Rütten
authors.forename: J
authors.initials: J
authors.lastname: Wiltfang
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000517:prevention & control*; D002320:Cardiovascular Physiological Phenomena; D003071:Cognition / Q000502:physiology; D023381:Endpoint Determination; D006801:Humans; D008019:Life Style; D009043:Motor Activity / Q000502:physiology*; D009424:Nervous System Physiological Phenomena; D010919:Placebos; D016032:Randomized Controlled Trials as Topic; D012107:Research Design
chemical_list: D010919:Placebos