Apoptosis and gene expression after TBI.
Proper CNS function depends on concerted expression of thousands of genes in a controlled and timely manner. Traumatic brain injury (TBI) in humans results in neuronal death and neurological dysfunction, which might be mediated by altered expression of several genes. By employing a CNS-specific GeneChip and real time polymerase chain reaction (PCR), the study analyzed the gene expression changes. The findings of necrosis and apoptosis can help to improve the wound age estimation after TBI in legal medicine.
Dressler
Jan
J
Institute of Legal Medicine, Technical University Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. Jan.Dressler@tu-dresden.de
Vemuganti
Raghu
R
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D017209:Apoptosis; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D001930:Brain Injuries / Q000235:genetics* / Q000473:pathology*; D017252:CD3 Complex / Q000032:analysis; D053148:Caspase 3 / Q000378:metabolism; D006098:Granulocytes / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008264:Macrophages / Q000276:immunology; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D017252:CD3 Complex; D053148:Caspase 3; C067980:CD68 antigen, human; D000097382:CD68 Molecule