Associations among hair loss, oral sulfur-containing gases, and gastrointestinal and metabolic linked diseases in Japanese elderly men: pilot study.
BACKGROUND
Male pattern baldness (MPB), an observable trait, has been reported to be associated with various diseases, such as prostate cancer and cardiovascular disease. Oral sulfur-containing gases have also been suggested to be useful as markers of systemic health condition. However, there are no known reports regarding the associations among MPB, and oral sulfur-containing gases, and systemic health conditions in males.


METHODS
We studied 170 male subjects aged either 60 or 65 years old. The degree of MPB was assessed using the Norwood-Hamilton Baldness scale. Oral sulfur-containing gases were measured using a compact-designed device. All subjects completed physical and laboratory blood examinations, a face-to-face medical questionnaire, and an oral examination.


RESULTS
There were significant differences between the levels of CH3SCH3 and baldness patterns, independent of age. When we analyzed whether the association was linked to systemic health condition, a strong significant association was observed between the level of CH3SCH3 and severe MPB in subjects with gastrointestinal diseases, hypertension, and hypercholesterolemia.


CONCLUSIONS
These results suggest that MPB is associated with the level of CH3SCH3, a sulfur-containing gas that causes oral malodor, in elderly Japanese males. Further, the association was intensified by the existence of gastrointestinal tract and metabolic disorders.
Ansai
Toshihiro
T
Division of Community Oral Health Science, Department of Health Promotion, Kyushu Dental College, Kitakyushu, Japan. ansai@kyu-dent.ac.jp
Awano
Shuji
S
Soh
Inho
I
Takata
Yutaka
Y
Yoshida
Akihiro
A
Hamasaki
Tomoko
T
Takehara
Tadamichi
T
D000368:Aged; D000505:Alopecia / Q000150:complications* / Q000503:physiopathology; D000704:Analysis of Variance; D001944:Breath Tests; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005740:Gases / Q000737:chemistry; D005767:Gastrointestinal Diseases / Q000150:complications*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D006973:Hypertension / Q000150:complications; D007564:Japan; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D013440:Sulfides / Q000032:analysis*; D013455:Sulfur / Q000032:analysis
D005740:Gases; D013440:Sulfides; D013455:Sulfur