Biological activity of secondary metabolites from Peltostigma guatemalense.
Leaves and wood of Peltostigma guatemalense, a novel species of the family Rutaceae, yielded a total of 14 secondary metabolites, i.e. methyl p-hydroxy benzoate, phenylacetic acid, beta-sitosterol, lupeol, syringaresinol, scopoletin, gardenin B (1), and seven alkaloids: gamma-fagarine (2), skimmianine (3), kokusaginine (4), 7-O-isopentenyl-gamma-fagarine (5), anhydro-evoxine (6), evoxine (7) and 4-methoxy-1-methyl-quinolin-2-one (8). The compounds have been identified by spectroscopic methods. Antibacterial and antimalarial in vitro activity of the isolated compounds were also determined. Methyl p-hydroxy benzoate and quinolone (8) were the most effective on Plasmodium falciparium strains.
Cuca Suarez
Luis Enrique
LE
Departamento de Quimica, Universidad Nacional de Colombia, Bogota, Colombia.
Pattarroyo
Manuel Elkin
ME
Lozano
Jose Manuel
JM
Delle Monache
Franco
F
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005663:Furans / Q000737:chemistry / Q000494:pharmacology; D017705:Lignans / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011804:Quinolines / Q000737:chemistry / Q000494:pharmacology; D027821:Rutaceae / Q000737:chemistry*; D012855:Sitosterols / Q000737:chemistry / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000494:pharmacology; D000094042:Lupanes
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000962:Antimalarials; D005663:Furans; D017705:Lignans; D053978:Pentacyclic Triterpenes; D010936:Plant Extracts; D011804:Quinolines; D012855:Sitosterols; D014315:Triterpenes; C042192:syringaresinol; C035932:skimmianine; C049193:gamma-fagarine; C025473:gamma-sitosterol; C010480:lupeol; D000094042:Lupanes