Autophagy and ethanol-induced liver injury.
The majority of ethanol metabolism occurs in the liver. Consequently, this organ sustains the greatest damage from ethanol abuse. Ethanol consumption disturbs the delicate balance of protein homeostasis in the liver, causing intracellular protein accumulation due to a disruption of hepatic protein catabolism. Evidence indicates that ethanol or its metabolism impairs trafficking events in the liver, including the process of macroautophagy, which is the engulfment and degradation of cytoplasmic constituents by the lysosomal system. Autophagy is an essential, ongoing cellular process that is highly regulated by nutrients, endocrine factors and signaling pathways. A great number of the genes and gene products that govern the autophagic response have been characterized and the major metabolic and signaling pathways that activate or suppress autophagy have been identified. This review describes the process of autophagy, its regulation and the possible mechanisms by which ethanol disrupts the process of autophagic degradation. The implications of autophagic suppression are discussed in relation to the pathogenesis of alcohol-induced liver injury.
Donohue
Terrence M
TM
Liver Study Unit, The Omaha Veterans Affairs Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68105, United States. tdonohue@unmc.edu
D000437:Alcoholism / Q000378:metabolism / Q000473:pathology; D001343:Autophagy / Q000187:drug effects* / Q000235:genetics; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity*; D005786:Gene Expression Regulation / Q000187:drug effects; D006529:Hepatomegaly / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008247:Lysosomes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects
D000431:Ethanol