Purinergic receptors in airway epithelia.
Nucleotides and nucleosides within the airway surface liquid regulate mucociliary clearance (MCC) activities, the primary innate defense mechanism that removes foreign particles and pathogens from airway surfaces. Nucleotide and nucleoside actions in the airways are mediated mainly by two purinergic receptor subtypes, the Gq-coupled ATP/UTP-sensing P2Y2 receptor and the Gs-coupled A2b adenosine receptor. Activation of the A2b receptor results in cyclic AMP-dependent activation of the cystic fibrosis transmembrane regulator (CFTR) Cl- channel and stimulation of ciliary beat frequency. Agonist occupation of the P2Y2 receptor promotes inhibition of Na+ absorption as well as CFTR-dependent and CFTR-independent Cl- secretion, ciliary beating, and mucin secretion.
Lazarowski
Eduardo R
ER
Cystic Fibrosis/Pulmonary Research & Treatment Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. eduardo_lazarowski@med.unc.edu
Boucher
Richard C
RC
D000241:Adenosine / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D018118:Chloride Channels / Q000378:metabolism; D006801:Humans; D009079:Mucociliary Clearance / Q000502:physiology; D009705:Nucleosides / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism; D058913:Purinergic Agonists; D058906:Purinergic P1 Receptor Agonists; D011983:Receptors, Purinergic / Q000378:metabolism*; D018047:Receptors, Purinergic P1 / Q000378:metabolism*; D020545:Respiratory Mucosa / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D018118:Chloride Channels; D009705:Nucleosides; D009711:Nucleotides; D058913:Purinergic Agonists; D058906:Purinergic P1 Receptor Agonists; D011983:Receptors, Purinergic; D018047:Receptors, Purinergic P1; D000255:Adenosine Triphosphate; D012964:Sodium; D000241:Adenosine