A detection system based on giant magnetoresistive sensors and high-moment magnetic nanoparticles demonstrates zeptomole sensitivity: potential for personalized medicine.
Zeptomole detector: A highly sensitive giant-magnetoresistive chip and FeCo nanoparticles can be used to linearly detect 600-4500 copies of streptavidin. Under unoptimized conditions, this system also detects human IL-6 with a sensitivity 13-times higher than that of standard ELISA techniques.
Srinivasan
Balasubramanian
B
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
Li
Yuanpeng
Y
Jing
Ying
Y
Xu
YunHao
Y
Yao
Xiaofeng
X
Xing
Chengguo
C
Wang
Jian-Ping
JP
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001710:Biotin / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D007501:Iron / Q000737:chemistry*; D008280:Magnetics / Q000295:instrumentation / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D040081:Protein Array Analysis; D015203:Reproducibility of Results; D019809:Streptavidin / Q000032:analysis
D015850:Interleukin-6; D003035:Cobalt; D001710:Biotin; D019809:Streptavidin; D007501:Iron