title: Animal models of tuberculosis for vaccine development.
abstract: Animal models for testing different vaccine candidates have been developed since a long time for studying tuberculosis. Mice, guinea pigs and rabbits are animals most frequently used. Each model has its own merits for studying human tuberculosis, and none completely mimics the human disease. Different animal models are being used depending upon the availability of the space, trained manpower as well as other resources. Efforts should continue to develop a vaccine which can replace/outperform the presently available vaccine BCG.
authors.affiliation: Experimental Animal Facility, National JALMA Institute for Leprosy & Other Mycobacterial Diseases, Agra, India. gdupg@yahoo.co.in
authors.forename: U D
authors.initials: UD
authors.lastname: Gupta
authors.forename: V M
authors.initials: VM
authors.lastname: Katoch
mesh_terms: D000818:Animals; D002417:Cattle; D004195:Disease Models, Animal; D055808:Drug Discovery / Q000379:methods*; D006168:Guinea Pigs; D008251:Macaca; D051379:Mice; D011817:Rabbits; D014376:Tuberculosis / Q000517:prevention & control*; D032581:Tuberculosis Vaccines
chemical_list: D032581:Tuberculosis Vaccines