title: [The expression and significance of integrin beta1 and focal adhesion kinase and its clinical value in laryngeal carcinoma].
abstract: OBJECTIVE
  To study the expressions and clinical significance of integrin beta1 and focal adhesion kinase (FAK) in laryngeal carcinoma (LSCC).
  
  
  METHODS
  The mRNA and protein levels of integrin beta1 and focal adhesion kinase and the surrounding tissue of laryngeal carcinoma in 48 specimens and 20 specimens of vocal cord polyp were detected by reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry SABC method.
  
  
  RESULTS
  The mRNA levels and positive rates of integrin beta1 and FAK protein were significantly higher in laryngeal carcinoma than that in the surrounding tissue and vocal cord polyp (P < 0.05). The expression levels of integrin beta1 and FAK were significantly higher in the group with cervical lymph node metastasis than those without (P < 0.05), and they were significantly higher in the tissue of stage of T3 and T4 than those of T1 and T2 (P < 0.05). But pathological grades was not significantly related with the expression levels of integrin beta1 or FAK (P > 0.05).
  
  
  CONCLUSIONS
  The expression levels of integrin beta1 and FAK were increased in LSCC, and they may contribute significantly to invasion and metastasis of LSCC.
authors.affiliation: Department of Otolaryngology, the First Affiliated Hospital of Jiaxing Medical College, Jiaxing, 314000, China. w.gb1988@163.com
authors.forename: Guobiao
authors.initials: G
authors.lastname: Wei
authors.forename: Yuxiao
authors.initials: Y
authors.lastname: Du
authors.forename: Chengzhang
authors.initials: C
authors.lastname: Yang
authors.forename: Xiaomeng
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005260:Female; D051417:Focal Adhesion Kinase 1 / Q000378:metabolism*; D006801:Humans; D019012:Integrin beta1 / Q000378:metabolism*; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D019012:Integrin beta1; D051417:Focal Adhesion Kinase 1; C496050:PTK2 protein, human