[Nanosystems and targeted transport of medicinal preparations to the brain].
Intense efforts in the last decades have resulted in numerous inventions to improve drug delivery to CNS. Some of them have significant potential for clinical applications. At the same time, the variety of these strategies is in itself indicative of great difficulties inherent in the transfer of therapeutic and imaging agents across the blood-brain barrier. Combination of several approaches, such as encapsulation of drugs in nanocontainers, incorporation in micellar nanostructures, the use of Pluronic "unimers" for inhibition of drug efflux in endothelial cells of brain capillaries, appears to be the most promising modality. The same refers to the methods of intracellular transport of drug suspensions developed recently. All these achievements provide a solid basis for the further improvement of drug pharmacokinetic properties, reduction of systemic toxicity, increase of therapeutic efficacy, and earlier diagnosis of CNS pathology.
Chekhonin
V P
VP
Dmitrieva
T B
TB
Zhirkov
Iu A
IuA
Kabanov
A V
AV
Gendel'man
Kh E
KhE
D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy*; D016503:Drug Delivery Systems / Q000295:instrumentation*; D015195:Drug Design; D006801:Humans; D053758:Nanoparticles / Q000008:administration & dosage*; D036103:Nanotechnology / Q000379:methods*