Reverse seroconversion of hepatitis B virus after allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease.
The appearance of hepatitis B surface antigen (HBsAg) in patients previously positive for antibody to this antigen (HBsAb) is called reverse seroconversion, a rare complication after hematopoietic stem cell transplantation (HSCT), which occurs almost exclusively after HSCT from an HBsAb-negative donor and the development of chronic graft-versus-host disease (CGVHD). However, we experienced a patient who developed reverse seroconversion 23 months after unrelated HSCT even in the absence of immunosuppressants use or CGVHD. Serum immunoglobulin level was persistently normal. Therefore, all HBsAb-positive recipients should be considered to be at risk for HBV reactivation, even in patients without any risk factors.
Oshima
Kumi
K
Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
Sato
Miki
M
Okuda
Shinya
S
Terasako
Kiriko
K
Nakasone
Hideki
H
Kako
Shinichi
S
Yamazaki
Rie
R
Tanaka
Yukie
Y
Tanihara
Aki
A
Higuchi
Takakazu
T
Nishida
Junji
J
Nakamura
Ikuo
I
Yoshida
Yukio
Y
Kanda
Yoshinobu
Y
D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006509:Hepatitis B / Q000097:blood / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D012189:Retrospective Studies; D014184:Transplantation, Homologous
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens