title: Correlation amyloid in brain, kidney, and CSF of castrated guinea pigs.
abstract: OBJECTIVE
  The association between low testosterone levels and Alzheimer's disease (AD) amyloid beta-peptide (Abeta) metabolism was investigated in brain and kidney of guinea pigs.
  
  
  METHODS
  The expression of Abeta peptide in the brain and kidney was assessed by using the immunohistochemistry method.
  
  
  RESULTS
  No expression of Abeta was seen in both groups of animals. This negative staining was found until the fourth week following castration. The formation of Abeta in guinea pigs is perhaps not a short duration process and may undergo different metabolic pathway compare to humans.
  
  
  CONCLUSIONS
  castration was not associated with the formation of Abeta in the brain and kidneys during a 1-month period and might require a longer period of time.
authors.affiliation: Medical Faculty, Pelita Harapan University-Neuroscience Centre, Siloam Hospitals Lippo Karawaci, Tangerang, Indonesia. eka@siloamhospitals.com
authors.forename: Eka J
authors.initials: EJ
authors.lastname: Wahjoepramonono
authors.forename: Vilia
authors.initials: V
authors.lastname: Aniwiyanti
authors.forename: Suga T
authors.initials: ST
authors.lastname: Anggawidjaja
authors.lastname: Yunianto
authors.forename: Irawan
authors.initials: I
authors.lastname: Yusuf
mesh_terms: D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D013739:Testosterone / Q000378:metabolism / Q000502:physiology; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D013739:Testosterone