Identification of a novel protein encoded by third conserved gene within RAG locus.
Recently, a third evolutionarily conserved gene, NWC, was discovered within the recombination activating gene (RAG) locus, known to contain the RAG1 and RAG2 genes. Here, we identify and characterize the murine endogenous NWC protein which has no homology to any known protein and is ubiquitously expressed. In the cell, the NWC protein which has been suggested to function as a transcriptional repressor, is found in the cytoplasm as well as in the nucleus.
Kasztura
Monika
M
Laboratory of Transgenesis and Lymphocyte Biology, Department of Tumor Immunology, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, Poland.
Miazek
Arkadiusz
A
Cebrat
Małgorzata
M
Kisielow
Paweł
P
D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D015180:Electrophoresis, Gel, Two-Dimensional; D019143:Evolution, Molecular; D016654:Genes, RAG-1 / Q000235:genetics*; D051379:Mice; D020133:Reverse Transcriptase Polymerase Chain Reaction
D017931:DNA Primers; D004268:DNA-Binding Proteins; C064655:V(D)J recombination activating protein 2