The anatomy of memory: an interactive overview of the parahippocampal-hippocampal network.
Converging evidence suggests that each parahippocampal and hippocampal subregion contributes uniquely to the encoding, consolidation and retrieval of declarative memories, but their precise roles remain elusive. Current functional thinking does not fully incorporate the intricately connected networks that link these subregions, owing to their organizational complexity; however, such detailed anatomical knowledge is of pivotal importance for comprehending the unique functional contribution of each subregion. We have therefore developed an interactive diagram with the aim to display all of the currently known anatomical connections of the rat parahippocampal-hippocampal network. In this Review, we integrate the existing anatomical knowledge into a concise description of this network and discuss the functional implications of some relatively underexposed connections.
van Strien
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NM
Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, The Netherlands. n.vanstrien@temporal-lobe.com
Cappaert
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NL
Witter
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D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D006801:Humans; D008568:Memory / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*