Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression.
To identify the structural requirements that are pivotal in enhancing Early growth response-1 (Egr-1) expression, the quantitative relationships between the structural properties of flavanone derivatives and their increments of Egr-1 expression were elucidated using comparative molecular field analysis and comparative molecular similarity indices analysis.
Lee
Sunhee
S
Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul, Republic of Korea.
Woo
Yoonkyung
Y
Shin
Soon Young
SY
Lee
Young Han
YH
Lim
Yoongho
Y
D051766:Early Growth Response Protein 1 / Q000096:biosynthesis* / Q000235:genetics*; D044950:Flavanones / Q000737:chemistry* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D021281:Quantitative Structure-Activity Relationship
D051766:Early Growth Response Protein 1; D044950:Flavanones