Physical activity, high-density lipoprotein cholesterol subfractions and lecithin:cholesterol acyltransferase in dialysis patients.
OBJECTIVE
Although a low level of high-density lipoprotein cholesterol (HDL-C) is an independent risk factor for atherosclerotic heart disease, the mechanism of HDL-C abnormality in hemodialysis (HD) as well as peritoneal dialysis (PD) patients is not fully understood. The purpose of this study was to investigate the relationship of physical activity with HDL-C subfractions and lecithin:cholesterol acyltransferase activity in HD and PD patients.


METHODS
Thirty-five HD and 26 PD patients were studied. Physical activity was estimated as the average number of steps taken per day over 7 days (steps/day).


RESULTS
When possible confounding factors were included in the stepwise multiple regression analyses, in HD patients, steps/day was significantly positively related to HDL(2)-C and apolipoprotein (Apo) A-I, while it was significantly positively related to HDL(3)-C in PD patients. When subjects were subdivided into 3 groups according to steps/day, in HD patients, the highest category of steps/day had significantly higher HDL(2)-C and Apo A-I than the lowest category, while such results were not observed in PD patients.


CONCLUSIONS
These results suggest that the associations of physical activity with HDL-C subfractions and Apo A-I that are known in the general population are more pronounced in HD patients than PD patients.
Masuda
Reika
R
Laboratory of Nutrition and Exercise Physiology, Nakamura Gakuen University Graduate School, 5-7-1 Befu, Jonan-ku, Fukuoka, Japan.
Imamura
Hiroyuki
H
Mizuuchi
Keiko
K
Miyahara
Keiko
K
Kumagai
Harumitsu
H
Hirakata
Hideki
H
D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D054709:Lecithins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D006435:Renal Dialysis; D002785:Sterol O-Acyltransferase / Q000097:blood*
D054709:Lecithins; D008075:Lipoproteins, HDL; D002785:Sterol O-Acyltransferase