title: [The correlation between interleukin-1 receptor antagonist genotype and coronary heart disease in patients with chronic periodontitis].
abstract: OBJECTIVE
  To investigate the correlation between interleukin-1 receptor antagonist (IL-1ra) genotype and chronic periodontitis in patients with coronary heart disease.
  
  
  METHODS
  Genomic DNA was obtained from buccal swabs in 86 patients with coronary heart disease,of which 45 patients with chronic periodontitis, the other without chronic periodontitis. Genotypes of IL-1RN intron 2 VNTR were analyzed by SSP-PCR method. Then the differences in distribution of each genotype were analyzed with SPSS 13.0 software package.
  
  
  RESULTS
  A significant over-representation of IL-1 RN intron 2 VNTR allele 2 was found in patients with coronary heart disease and chronic periodontitis group (chi(2)=4.960,P=0.026).
  
  
  CONCLUSIONS
  IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of chronic periodontitis in patients with coronary heart disease.
authors.affiliation: Department of Stomatology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: Meng
authors.initials: M
authors.lastname: Chu
authors.forename: Liang-jun
authors.initials: LJ
authors.lastname: Zhong
authors.forename: Sheng-biao
authors.initials: SB
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
authors.forename: Han
authors.initials: H
authors.lastname: Jiang
mesh_terms: D000483:Alleles; D055113:Chronic Periodontitis; D003327:Coronary Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D012307:Risk Factors
chemical_list: D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1