title: Interleukin-1 gene cluster polymorphisms and gingival recessions after orthodontic treatment.
abstract: BACKGROUND
  Genetic polymorphisms in the interleukin-1 gene cluster have been associated with the severity of periodontal diseases featured by a variable degree of destruction of connective tissue and bone, such as periodontitis and periimplantitis. This study was aimed to investigate if a link exists between such interleukin-1 gene polymorphisms and the development of gingival recessions during orthodontic treatment in Italian children.
  
  
  METHODS
  We evaluated, in 74 young Italian patients of both sexes, the -889 C/T polymorphism of the interleukin-1alpha gene and the -511 C/T and +3954 C/T polymorphisms of interleukin-1alpha gene by polymerase chain reactions-restriction fragment length polymorphism method using NcoI, AvaI and TaqI as restriction enzymes.
  
  
  RESULTS
  No association of interleukin-1 genotypes investigated and gingival recession occurring during orthodontic treatment were identified.
  
  
  CONCLUSIONS
  In the population studied specific interleukin-1 genotypes (linked to a higher susceptibility to bone resorption in periodontal disease) there does not appear to be any association with the development of gingival recessions during orthodontic treatment.
authors.affiliation: Department of Genetics, Biology and Biochemistry, University of Torino, Italy.
authors.forename: Loredana
authors.initials: L
authors.lastname: Bergandi
authors.forename: Rachele
authors.initials: R
authors.lastname: Rubiano
authors.forename: Matteo
authors.initials: M
authors.lastname: Brunazzo
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Aldieri
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Alfieri
authors.forename: Paola
authors.initials: P
authors.lastname: Dalmasso
authors.forename: Paola
authors.initials: P
authors.lastname: Dal Masso
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cardaropoli
authors.forename: Pietro
authors.initials: P
authors.lastname: Bracco
authors.forename: Cesare
authors.initials: C
authors.lastname: Debernardi
authors.forename: Dario
authors.initials: D
authors.lastname: Ghigo
mesh_terms: D000293:Adolescent; D002648:Child; D020022:Genetic Predisposition to Disease; D005889:Gingival Recession / Q000209:etiology / Q000235:genetics*; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D008310:Malocclusion / Q000628:therapy; D005810:Multigene Family / Q000235:genetics; D009811:Odontometry; D011110:Polymorphism, Genetic; D014087:Tooth Movement Techniques / Q000009:adverse effects*
chemical_list: D053582:Interleukin-1alpha