title: Fibrinogen plasma levels are an independent prognostic parameter in patients with cervical cancer.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the association between fibrinogen plasma levels on disease-free patients and overall survival in patients with cervical cancer.
  
  
  METHODS
  Pretherapeutic fibrinogen plasma levels were examined in 313 patients with cervical cancer who were treated at the Department of Obstetrics and Gynecology, Medical University of Vienna. Fibrinogen plasma levels were correlated with clinical-pathologic findings and patient survival.
  
  
  RESULTS
  Mean (+/- SD) pretherapeutic fibrinogen plasma levels were 417.4 mg/dL (+/- 130.3 mg/dL). Elevated fibrinogen plasma levels were associated with advanced tumor stage (P < .001) and patient age (P < .001), but not with histologic type (P = .4), histologic grade (P = .1), and pelvic lymph node involvement (P = .9). In a multivariate survival analysis, fibrinogen plasma levels (P < .001 and < .001) and lymph node involvement (P < .001 and = .001), but not patients' age (P = .8 and .4) and histologic type (P = .7 and .5) were associated with overall or disease-free survival, respectively. Histologic grade was associated with disease-free (P = .01), but not with overall, survival (P = .2).
  
  
  CONCLUSIONS
  Fibrinogen plasma levels are an independent prognostic parameter in patients with cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria. stephan.polterauer@meduniwien.ac.at
authors.forename: Stephan
authors.initials: S
authors.lastname: Polterauer
authors.forename: Veronika
authors.initials: V
authors.lastname: Seebacher
authors.forename: Katrin
authors.initials: K
authors.lastname: Hefler-Frischmuth
authors.forename: Christoph
authors.initials: C
authors.lastname: Grimm
authors.forename: Georg
authors.initials: G
authors.lastname: Heinze
authors.forename: Clemens
authors.initials: C
authors.lastname: Tempfer
authors.forename: Alexander
authors.initials: A
authors.lastname: Reinthaller
authors.forename: Lukas
authors.initials: L
authors.lastname: Hefler
mesh_terms: D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000401:mortality*
chemical_list: D005340:Fibrinogen