title: Efficient one-pot synthesis of indol-3-yl-glycines via uncatalyzed Friedel-Crafts reaction in water.
abstract: The three component reaction of primary aliphatic amines, glyoxalic acid and indole or N-methylindole in water at ambient temperature affords indol-3-yl or N-methylindol-3-yl-glycine in almost quantitative yields.
authors.affiliation: School of Chemistry, University College of Science, University of Tehran, Tehran, Iran. ghandi@khayam.ut.ac.ir
authors.forename: Mehdi
authors.initials: M
authors.lastname: Ghandi
authors.forename: Abuzar
authors.initials: A
authors.lastname: Taheri
mesh_terms: D000588:Amines / Q000737:chemistry; D005998:Glycine / Q000138:chemical synthesis*; D006038:Glyoxylates / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D014867:Water
chemical_list: D000588:Amines; D006038:Glyoxylates; D007211:Indoles; D014867:Water; C031150:glyoxylic acid; D005998:Glycine