Influence of water-soluble flavonoids, quercetin-5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model.
Water-soluble quercetin-5'-sulfonic acid sodium salt (NaQSA) and morin-5'-sulfonic acid sodium salt (NaMSA) could exert an antagonistic effect on cadmium intoxication. The aim of the study was to examine the influence of these substances on superoxide dismutase (SOD) and glutathione (GSH) levels in the mouse liver in the subacute cadmium intoxication model. NaQSA and NaMSA significantly counteracted cadmium-induced decreases in SOD and GSH levels. No significant differences in SOD and GSH levels between groups exposed to cadmium receiving NaQSA or/and NaMSA were observed.
Chlebda
Ewa
E
Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, PL-50-345 Wroclaw, Poland. echlebda@mp.pl
Magdalan
Jan
J
Merwid-Lad
Anna
A
Trocha
Małgorzata
M
Kopacz
Maria
M
Kuźniar
Anna
A
Nowak
Dorota
D
Szelag
Adam
A
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002105:Cadmium Poisoning / Q000188:drug therapy*; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000187:drug effects; D047309:Flavones
D000975:Antioxidants; D005419:Flavonoids; D005978:Glutathione; D011794:Quercetin; D013482:Superoxide Dismutase; C502510:quercetin-5'-sulfonic acid; C008548:morin; D047309:Flavones