Afferent islands are larger than mu-opioid receptor patch in striatum of rat pups.
Dopamine afferent islands were observed in rodent caudate-putamen only during development, whereas patches with intense mu-opioid receptor (MOR) immunoreactivity were seen throughout the life. We performed direct comparison between MOR patches and dopamine islands in the caudate-putamen of rat pups, by double immunofluorescence labeling for MOR and tyrosine hydroxylase. MOR patches were included in dopamine islands at postnatal day (P) 0 to P8, although the patches occupied the same region as the islands at P12-16. Furthermore, the regions of glutamatergic afferents with intense vesicular glutamate transporter 1 and vesicular glutamate transporter 2 immunoreactivities well corresponded to those of dopamine islands at P4. These results suggest that the striatal 'afferent islands' are larger than MOR patches in the early postnatal life.
Nakamura
Kouichi C
KC
Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan. nakamura@mbs.med.kyoto-u.ac.jp
Fujiyama
Fumino
F
Furuta
Takahiro
T
Hioki
Hiroyuki
H
Kaneko
Takeshi
T
D000818:Animals; D002421:Caudate Nucleus / Q000254:growth & development / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D009474:Neurons / Q000378:metabolism*; D011699:Putamen / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D050599:Vesicular Glutamate Transport Protein 2 / Q000378:metabolism
D017450:Receptors, Opioid, mu; D050599:Vesicular Glutamate Transport Protein 2; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine