ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas.
Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.
Burim
Regislaine Valéria
RV
Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP 14040-903, Brazil. rvburim@fcfrp.usp.br
Teixeira
Silvia Aparecida
SA
Colli
Benedicto Oscar
BO
Peria
Fernanda Maris
FM
Tirapelli
Luis Fernando
LF
Marie
Suely Kazue Nagahashi
SK
Malheiros
Suzana Maria Fleury
SM
Oba-Shinjo
Sueli Mieko
SM
Gabbai
Alberto Alain
AA
Lotufo
Paulo Andrade
PA
Carlotti-Júnior
Carlos Gilberto
CG
D001254:Astrocytoma / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D019408:Platelet Endothelial Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1