Ccbe1 is required for embryonic lymphangiogenesis and venous sprouting.
Lymphatic vessels have important roles in fluid homeostasis, fat absorption, inflammation and cancer metastasis and develop in a dynamic process (called lymphangiogenesis) involving budding, migration and proliferation of lymphangioblasts. Using a genetic screen in zebrafish we identify ccbe1 (collagen and calcium-binding EGF domain-1) as indispensible for embryonic lymphangiogenesis. Ccbe1 acts at the same stage of development as Vegfc and is required for lymphangioblast budding and angiogenic sprouting from venous endothelium.
Hogan
Benjamin M
BM
Hubrecht Institute-KNAW & University Medical Centre, Utrecht, The Netherlands.
Bos
Frank L
FL
Bussmann
Jeroen
J
Witte
Merlijn
M
Chi
Neil C
NC
Duckers
Henricus J
HJ
Schulte-Merker
Stefan
S
D019943:Amino Acid Substitution; D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D002455:Cell Division; D002465:Cell Movement; D004625:Embryo, Nonmammalian / Q000502:physiology; D047108:Embryonic Development; D004815:Epidermal Growth Factor / Q000235:genetics*; D006801:Humans; D042583:Lymphangiogenesis / Q000235:genetics*; D042601:Lymphatic Vessels / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D023421:Models, Animal; D009154:Mutation; D042582:Vascular Endothelial Growth Factor C / Q000235:genetics; D015027:Zebrafish
C467486:VEGFC protein, human; D042582:Vascular Endothelial Growth Factor C; D004815:Epidermal Growth Factor; D002118:Calcium