Presence of thrombin-activatable fibrinolysis inhibitor in Helicobacter pylori-associated gastroduodenal disease.
Thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role in the regulation of coagulation and inflammation. In addition to inhibiting the fibrinolytic system, TAFI may also regulate the bradykinin and complement systems. We hypothesized that TAFI also plays a role in defense mechanisms of the gastric mucosa during Helicobacter pylori infection. This study comprised 65 patients with gastroduodenal disorders: 41 patients with H. pylori infection, 13 without, and 11 patients with cured H. pylori infection. The gastric intramucosal concentrations of TAFI were measured by enzyme immunoassay. The gastric levels of TAFI and plasminogen activator inhibitor-1 were significantly increased in patients with H. pylori compared to those without infection or cured H. pylori. The presence of TAFI was detected in gastric mucosal epithelial cells. The concentration of TAFI was correlated with the degree of gastric mucosal atrophy, inflammation, and disease activity. These results show that TAFI is present in the gastric mucosa and that it may play a role in the pathogenesis of H. pylori infection-associated gastroduodenal disorders.
Ikeda
Ayumi
A
Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu-city, Mie, Japan.
Gabazza
Esteban C
EC
Morser
John
J
Imoto
Ichiro
I
Kuroda
Mikihito
M
D'Alessandro-Gabazza
Corina N
CN
Hara
Kenichiro
K
Ruiz
Daniel Boveda
DB
Bernabe
Paloma Gil
PG
Katsurahara
Masaki
M
Toda
Masaaki
M
Kobayashi
Yoshinao
Y
Yano
Yutaka
Y
Sumida
Yasuhiro
Y
Suzuki
Koji
K
Taguchi
Osamu
O
Takei
Yoshiyuki
Y
D025901:Carboxypeptidase B2 / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000378:metabolism; D004378:Duodenal Diseases / Q000378:metabolism* / Q000382:microbiology; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology; D016481:Helicobacter Infections / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification* / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D013272:Stomach Diseases / Q000378:metabolism* / Q000382:microbiology
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D005340:Fibrinogen; D025901:Carboxypeptidase B2