title: Pylephlebitis after a duodenal ulcer in a patient with metastasised colon carcinoma treated with chemotherapy and bevacizumab: a case report.
abstract: Pylephlebitis or septic thrombophlebitis of the portal vein is a rare entity with a high mortality rate. It is often a complication of intra-abdominal infection most commonly caused by diverticulitis and appendicitis. Diagnosis is often delayed since clinical signs and symptoms are nonspecific. Pylephlebitis should be considered in patients with sepsis due to gut-associated organisms without a clear focus of infection. We describe a patient with metastastatic colon carcinoma treated with chemotherapy and bevacizumab who was diagnosed with pylephlebitis after a duodenal ulcer and responded well to antibiotic treatment.
authors.affiliation: Departments of Medical Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, the Netherlands.
authors.forename: L
authors.initials: L
authors.lastname: Mannaerts
authors.forename: C P
authors.initials: CP
authors.lastname: Bleeker-Rovers
authors.forename: M
authors.initials: M
authors.lastname: Koopman
authors.forename: C J A
authors.initials: CJ
authors.lastname: Punt
authors.forename: C M L
authors.initials: CM
authors.lastname: van Herpen
mesh_terms: D000368:Aged; D000658:Amoxicillin / Q000627:therapeutic use; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000209:etiology*; D000068258:Bevacizumab; D019818:Clavulanic Acid / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D004381:Duodenal Ulcer / Q000150:complications*; D006801:Humans; D008297:Male; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D010878:Piperacillin / Q000627:therapeutic use; D011169:Portal Vein / Q000473:pathology*; D000078142:Tazobactam; D013924:Thrombophlebitis / Q000209:etiology*
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D000970:Antineoplastic Agents; D019818:Clavulanic Acid; D000068258:Bevacizumab; D000658:Amoxicillin; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin