title: The IL-16 gene polymorphisms and the risk of the systemic lupus erythematosus.
abstract: BACKGROUND
  Interleukin 16 (IL-16) is an immunomodulatory cytokine which plays an important role in many inflammatory and autoimmune diseases. We determined the association between SNPs of IL-16 gene (i.e. rs11556218 G/T, rs4778889 C/T, and rs4072111 C/T) and systemic lupus erythematosus (SLE).
  
  
  METHODS
  One hundred thirty-eight SLE patients and 199 controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and DNA sequencing assay.
  
  
  RESULTS
  In the SLE group, the individuals carrying the G allele of rs11556218, the C allele of rs4778889 and the T allele of rs4072111 are at a significantly higher risk of SLE as compared with those carrying the T allele of rs11556218, the T allele of rs4778889, and the C allele of rs4072111 respectively (for rs11556218, OR=2.264, 95% CI, 1.64-3.127; for rs4778889, OR=1.927, 95%CI, 1.359-2.731; and for rs4072111, OR=2.417, 95% CI, 1.691-3.455).
  
  
  CONCLUSIONS
  The IL-16 gene polymorphisms may be associated with the risk of SLE.
authors.affiliation: Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xue
authors.forename: Linbo
authors.initials: L
authors.lastname: Gao
authors.forename: Yongkang
authors.initials: Y
authors.lastname: Wu
authors.forename: Wenliang
authors.initials: W
authors.lastname: Fang
authors.forename: Lanlan
authors.initials: L
authors.lastname: Wang
authors.forename: Cui
authors.initials: C
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Weibo
authors.initials: W
authors.lastname: Liang
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic
chemical_list: D019410:Interleukin-16