Estimating the prevalence of myelodysplastic syndromes in patients with unexplained cytopenias: a retrospective study of 322 bone marrows.
Although unexplained anemia is common in the elderly, the prevalence of MDS is poorly defined. We reviewed 2267 bone marrows reviewed at our center between the years 2002 and 2005. Of these, 322 met our criteria for inclusion (14%). Seventy-three patients (22.6%) had a confirmed diagnosis of MDS and 32 (9.9%) had suspected MDS. Confirmed or suspected MDS was more likely in patients aged >65 (31.5% and 11%, respectively). Age, MCV, LDH and RDW were independently predictive of MDS. Extrapolation of our findings to the elderly anemic individuals in the community suggests MDS prevalence may be higher than previously postulated.
Buckstein
Rena
R
MDS Research Program, Department of Hematology/Oncology, Odette Cancer Center, Sunnybrook Health Sciences Center, Toronto, Ontario, Canada. rena.buckstein@sunnybrook.ca
Jang
Karen
K
Friedlich
Jessica
J
Zhang
Liying
L
Reis
Marciano
M
Chesney
Alden
A
Wells
Richard A
RA
D000368:Aged; D000740:Anemia / Q000097:blood / Q000453:epidemiology; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D007621:Karyotyping; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007970:Leukopenia / Q000097:blood / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000473:pathology; D010198:Pancytopenia / Q000097:blood / Q000453:epidemiology / Q000235:genetics; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000097:blood / Q000453:epidemiology
D007770:L-Lactate Dehydrogenase