title: Chronic nonhealing ulcer of the right thumb with multiple subcutaneous nodules.
abstract: A 60-year-old man presented with a 3-month history of nonhealing ulcer over the tip of his right thumb. The ulcer started as a blister over the tip of the thumb that later ruptured and spread proximally to cover the whole pulp area of the thumb. There was no history of trauma, fever, weight loss, or loss of appetite. He is a pensioner and an avid gardener. He has a few cats as pets. The patient initially presented to a private orthopedic surgeon with a nonhealing ulcer of the right thumb. Multiple debridements were unsuccessful in ameliorating the ulcer. Three months after the onset of the initial lesion, multiple painless erythematous nodules had developed on his right arm, and one on the right thigh. All routine blood investigations were nondiagnostic. Swab culture from the ulcer failed to grow any organism and a course of antibiotics did not resolve the problem. Cultures of the biopsy specimen using Sabouraud's dextrose agar and potato carrot medium grew dark brown plaques that microscopically appeared to be branching hyphae. A diagnosis of sporotrichosis of the right upper limb was made and the patient was started on antifungal treatment immediately (T. Itraconazole [Sporanox] 200 mg BD). One month after commencement of antifungal treatment, the ulcer began to dry up and at 3 months all the lesions including the one on the right thigh had healed.
authors.affiliation: Department of Orthopedic Surgery, Faculty of Medicine and Health Science, Universiti Putra Malaysia Jalan Puchong, 43400, Serdang, Selangor, Malaysia.
authors.forename: Arumugam
authors.initials: A
authors.lastname: Manohar
authors.forename: Mohd N
authors.initials: MN
authors.lastname: Nizlan
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000175:diagnosis / Q000601:surgery; D002908:Chronic Disease; D003937:Diagnosis, Differential; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000175:diagnosis / Q000601:surgery; D012883:Skin Ulcer / Q000175:diagnosis* / Q000188:drug therapy*; D013174:Sporotrichosis / Q000175:diagnosis* / Q000188:drug therapy*; D013933:Thumb / Q000473:pathology*; D017211:Treatment Failure; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole