title: Synthesis and cytotoxicity of 2-cyano-28-hydroxy-lup-1-en-3-ones.
abstract: New A-ring modified betulin and dihydrobetulin derivatives possessing the 2-cyano-1-en-3-one moiety were prepared and tested for cytotoxicity in seven cancer cell lines. The most active agent 9a synthesized in this account was further demonstrated to induce apoptosis and to activate caspases in malignant melanoma cells.
authors.affiliation: Advanced Life Sciences, Inc, Research and Development, Woodridge, IL 60517, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Koohang
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Majewski
authors.forename: Erika L
authors.initials: EL
authors.lastname: Szotek
authors.forename: Aye Aye
authors.initials: AA
authors.lastname: Mar
authors.forename: David A
authors.initials: DA
authors.lastname: Eiznhamer
authors.forename: Michael T
authors.initials: MT
authors.lastname: Flavin
authors.forename: Ze-Qi
authors.initials: ZQ
authors.lastname: Xu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006131:Growth Inhibitors / Q000138:chemical synthesis* / Q000633:toxicity*; D006801:Humans; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000138:chemical synthesis* / Q000633:toxicity*; D000094062:Betulinic Acid
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D000094062:Betulinic Acid