title: Chronic effects of flunitrazepam on shock-induced behavioral inhibition   in adult male rats.
abstract: Flunitrazepam has been reported to trigger cases of extreme violence in man and recently it was shown to heighten aggression in experimental rats. The underlying mechanisms may involve disinhibited/impulsive behavior. Here, tolerance developed to the behavioral disinhibiting effect of flunitrazepam in Vogel's drinking conflict model, both in rats treated with flunitrazepam (0.32 mg/kg/day) for three weeks, as well as in rats treated for six weeks (0.32 mg/kg/day three weeks + 0.56 mg/kg/day three weeks). The results suggest that behavioral disinhibition is of limited importance in the mechanisms underlying the pro-aggressive effect of chronic flunitrazepam administration.
authors.affiliation: Addiction Biology Unit, Section of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Box 410, S-405 30 Göteborg, Sweden. anders.svensson@neuro.gu.se
authors.forename: Anders I
authors.initials: AI
authors.lastname: Svensson
mesh_terms: D000818:Animals; D003220:Conflict, Psychological; D004361:Drug Tolerance; D004558:Electric Stimulation; D005445:Flunitrazepam / Q000008:administration & dosage* / Q000494:pharmacology*; D007266:Inhibition, Psychological; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D005445:Flunitrazepam