title: Nevus spilus with synchronous melanomas: case report and literature review.
abstract: BACKGROUND
  Nevus spilus is a rare, acquired, and often large cutaneous lesion consisting of a light brown background macule containing varying numbers of small darker macular or papular areas.
  
  
  OBJECTIVE
  Nevus spilus may contain dysplastic melanocytic elements, and there are also reports of melanoma arising from nevus spilus. However, the absolute risk for malignant transformation is not well defined.
  
  
  CONCLUSIONS
  We discuss a case of synchronous melanomas arising from a nevus spilus and potential management recommendations based on a review of the pertinent literature.
authors.affiliation: Department of Surgical Oncology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA. ari-nareg.meguerditchian@roswellpark.org
authors.forename: Ari-Nareg
authors.initials: AN
authors.lastname: Meguerditchian
authors.forename: Richard T
authors.initials: RT
authors.lastname: Cheney
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
mesh_terms: D006801:Humans; D008297:Male; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000601:surgery; D009506:Nevus / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy