Synthesis of hindered biphenyls by sequential non-transition metal-catalyzed reaction/palladium-catalyzed cross-couplings.
The sequential reaction of 1,2-dihalobenzenes with aryl lithiums followed by palladium-catalyzed cross-coupling reactions with Grignard reagents and arylboronic acids is described. This sequential reaction provides a convenient and expeditious access to tri-ortho substituted biaryl derivatives.
He
Ping
P
Department of Chemistry, College of Staten Island and the Graduate Center of the City University of New York, Staten Island, New York 10314.
Dong
Cheng-Guo
CG
Hu
Qiao-Sheng
QS