title: Advances in mechanisms of asthma, allergy, and immunology in 2008.
abstract: This review summarizes selected articles appearing in 2008 in the Journal. Articles chosen include those improving our understanding of mechanisms of allergic diseases by focusing on human basophil, mast cell, and eosinophil biology; IgE and its high-affinity receptor on various cells; novel properties of omalizumab; airways remodeling; and genetics. Articles from other journals have been included to supplement the topics presented.
authors.affiliation: Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, and Harvard Medical School, Boston, Mass, USA.
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Boyce
authors.forename: David
authors.initials: D
authors.lastname: Broide
authors.forename: Kenji
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Bruce S
authors.initials: BS
authors.lastname: Bochner
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D001491:Basophils / Q000276:immunology* / Q000378:metabolism; D015550:Cell Degranulation / Q000276:immunology; D004804:Eosinophils / Q000276:immunology* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D007073:Immunoglobulin E / Q000097:blood; D018836:Inflammation Mediators / Q000276:immunology* / Q000378:metabolism; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism; D000069444:Omalizumab
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D018836:Inflammation Mediators; D000069444:Omalizumab; D007073:Immunoglobulin E