The role of hypoxia-inducible factor in osteogenesis and chondrogenesis.
Oxygen availability is a critical signal for the proper development of many tissues. The transcription factor hypoxia-inducible factor (HIF) plays an important role in maintenance of oxygen homeostasis in all metazoans. Numerous growth and transcription factors have been implicated in the development of the skeletal system. Many of the factors that are up-regulated during hypoxia are downstream of HIF activation. Recent work has demonstrated that HIF has a critical function in cartilage and bone development. We summarize current understanding of the role of HIF in bone and cartilage development.
Sun
Xiaotang
X
Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China.
Wei
Yiyong
Y
D000818:Animals; D017209:Apoptosis; D020219:Chondrogenesis; D005260:Female; D047109:Fetal Development; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism*; D007231:Infant, Newborn; D010012:Osteogenesis; D018384:Oxidative Stress; D010101:Oxygen Consumption; D011247:Pregnancy
D051793:Hypoxia-Inducible Factor 1