Synthesis and anti-HSV-1 evaluation of some pyrazoles and fused pyrazolopyrimidines.
5-Amino-1-substituted-1H-pyrazole-4-carbonitrile derivative 1 was used as a precursor for preparation of some novel substituted pyrazole and pyrazolo[3,4-d]pyrimidine derivatives 2-10. Furthermore, the preparation of sugar hydrazone derivatives 11a,b, 12a,b and their annelated C-nucleosides 13a,b was described. Some of the prepared products revealed promising antiviral activity against herpes simplex virus type-1 (HSV-1) in comparison to Acyclovir as a control.
Rashad
Aymn E
AE
Photochemistry Department, National Research Centre, Behos Street, Dokki, Cairo, Egypt. aymnelzeny@yahoo.com
Hegab
Mohamed I
MI
Abdel-Megeid
Randa E
RE
Fathalla
Nahed
N
Abdel-Megeid
Farouk M E
FM
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D011720:Pyrazoles; D011743:Pyrimidines