title: [Association of interleukin-1B gene polymorphisms with coronary heart disease].
abstract: OBJECTIVE
  To determine whether polymorphisms in interleukin-1B gene promoter -31 and exon 5 +3953 loci are associated with coronary heart diseases (CHD) in Chengdu Han population.
  
  
  METHODS
  Two SNPs of IL-1B gene (+3953C/T and -31T/C) in 100 patients with CHD (CHD group) and 144 healthy controls in Chengdu were analysed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  Two genotypes at IL-1B + 3953 locus (CC and CT) and 3 genotypes at IL-1B -31 locus (CC, TC and TT) were identified. The -31T alleles carriers were associated with a significantly increased risk of CHD as compared with the non-carriers (OR = 2.12, 95% CI: 1.45-3.09, P < 0.01). Genotypes and allele frequencies at IL-1B + 3953 locus in CHD cases did not differ from the controls.
  
  
  CONCLUSIONS
  IL-1B -31T/C polymorphism may contribute to the risk of developing CHD in Chengdu Han population.
authors.affiliation: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
authors.forename: Yin-Hua
authors.initials: YH
authors.lastname: Zhu
authors.forename: Yong-Chun
authors.initials: YC
authors.lastname: Xu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Liang
authors.forename: Yan-Yun
authors.initials: YY
authors.lastname: Wang
authors.forename: Lin-Bo
authors.initials: LB
authors.lastname: Gao
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002681:China; D003327:Coronary Disease / Q000235:genetics*; D005091:Exons / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D053583:Interleukin-1beta