title: Drug treatment of epilepsy in the century of the ILAE: the first 50 years, 1909-1958.
abstract: This paper provides a review of the drug treatment of epilepsy from 1909, the year of the foundation of the International League Against Epilepsy (ILAE), to 1958. It was during this period that modern approaches to the medicinal therapy of epilepsy were formulated and many new drugs were introduced. Of these, both phenytoin and phenobarbital continue to be widely used today. This was the period when scientific screening was also introduced into drug discovery. The leading figures in the ILAE played an important role in guiding the evolution of the treatment of epilepsy during this period.
authors.affiliation: UCL Institute of Neurology, University College London, London, United Kingdom. s.shorvon@ion.ucl.ac.uk
authors.forename: Simon D
authors.initials: SD
authors.lastname: Shorvon
mesh_terms: D000329:Advertising / Q000266:history; D000927:Anticonvulsants / Q000266:history* / Q000627:therapeutic use; D001965:Bromides / Q000266:history / Q000627:therapeutic use; D004827:Epilepsy / Q000188:drug therapy / Q000266:history*; D029001:Herbal Medicine / Q000266:history; D049671:History, 18th Century; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D009462:Neurology / Q000266:history; D010634:Phenobarbital / Q000266:history / Q000627:therapeutic use; D010672:Phenytoin / Q000266:history / Q000627:therapeutic use; D013782:Textbooks as Topic / Q000266:history
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D010672:Phenytoin; D010634:Phenobarbital