In vivo evidence of hepato- and reno-protective effect of garlic oil against sodium nitrite-induced oxidative stress.
Sodium nitrite (NaNO2), a food color fixative and preservative, contributes to carcinogenesis. We investigated the protective role of garlic oil against NaNO2-induced abnormalities in metabolic biochemical parameters and oxidative status in male albino rats. NaNO2 treatment for a period of three months induced a significant increase in serum levels of glucose, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bilirubin, urea and creatinine as well as hepatic AST and ALT. However, significant decrease was recorded in liver ALP activity, glycogen content, and renal urea and creatinine levels. In parallel, a significant increase in lipid peroxidation, and a decrease in glutathione content and catalase activity were observed in the liver and the kidney. However, garlic oil supplementation showed a remarkable amelioration of these abnormalities. Our data indicate that garlic is a phytoantioxidant with powerful chemopreventive properties against chemically-induced oxidative stress.
Hassan
Hanaa A
HA
Department of Zoology, Faculty of Science, Mansoura University, Mansoura, Egypt.
El-Agmy
Sherif M
SM
Gaur
Rajiv L
RL
Fernando
Augusta
A
Raj
Madhwa Hg
MH
Ouhtit
Allal
A
D000410:Alanine Transaminase / Q000097:blood / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000097:blood; D000498:Allyl Compounds / Q000494:pharmacology*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood / Q000378:metabolism; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002273:Carcinogens / Q000633:toxicity; D002374:Catalase / Q000032:analysis; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D005978:Glutathione / Q000032:analysis; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009566:Nitrates / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D013440:Sulfides / Q000494:pharmacology*; D014508:Urea / Q000097:blood / Q000378:metabolism
D000498:Allyl Compounds; D016588:Anticarcinogenic Agents; D001786:Blood Glucose; D002273:Carcinogens; D004042:Dietary Fats, Unsaturated; D008112:Liver Glycogen; D009566:Nitrates; D013440:Sulfides; C038491:allyl sulfide; C031618:sodium nitrate; D014508:Urea; D003404:Creatinine; D002374:Catalase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005978:Glutathione; D001663:Bilirubin