Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.
Xie
Yuli
Y
Department of Medicine, Columbia University, New York, NY 10032, USA.
Liu
Yidong
Y
Gong
Gangli
G
Smith
Deborah H
DH
Yan
Fang
F
Rinderspacher
Alison
A
Feng
Yan
Y
Zhu
Zhengxiang
Z
Li
Xiangpo
X
Deng
Shi-Xian
SX
Branden
Lars
L
Vidović
Dusica
D
Chung
Caty
C
Schürer
Stephan
S
Morisseau
Christophe
C
Hammock
Bruce D
BD
Landry
Donald W
DW
D055808:Drug Discovery / Q000379:methods*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D012995:Solubility; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry / Q000145:classification / Q000378:metabolism* / Q000494:pharmacology
D014508:Urea; D004851:Epoxide Hydrolases