The synthesis and characterization of [(124)I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer's disease.
6-[(124)I]iodo-2-(4'-N,N-dimethylamino)-phenylimidazo[1,2-a]pyridine ([(124)I]IMPY) was synthesized and characterized as a positron-emitting probe to identify Alzheimer's disease in transgenic mouse models. A significant reduction in radioactivity retention in the hippocampus and frontal cortex by co-incubation with nonradioactive IMPY was observed. Highly specific retention of radioactivity in beta-amyloid-rich regions of brain sections was also noted. This study demonstrated that [(124)I]IMPY was a promising probe for the mouse model and may be useful for positron emission tomography to image beta-amyloid plaques in the human brain.
Chang
K W
KW
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, No. 155, Sect. 2, Li-Nong St., Taipei 112, Taiwan.
Chen
C C
CC
Lee
S Y
SY
Shen
L H
LH
Wang
H E
HE
D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016229:Amyloid beta-Peptides / Q000032:analysis; D000818:Animals; D052160:Benzothiazoles; D001921:Brain / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006624:Hippocampus / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D051379:Mice; D008822:Mice, Transgenic; D058225:Plaque, Amyloid / Q000000981:diagnostic imaging*; D049268:Positron-Emission Tomography; D011725:Pyridines / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D011877:Radionuclide Imaging / Q000379:methods; D013844:Thiazoles / Q000737:chemistry; D014018:Tissue Distribution
C473191:6-iodo-2-(4'-dimethylamino-)phenyl-imidazo(1,2-a)pyridine; D016229:Amyloid beta-Peptides; D052160:Benzothiazoles; D007457:Iodine Radioisotopes; D011725:Pyridines; D013844:Thiazoles; C009462:thioflavin T