The search for the mechanism of the reaction catalyzed by farnesyltransferase.
Atomic-level portrait: The mechanism of the reaction catalyzed by the puzzling enzyme farnesyltransferase is elucidated by using computational methods, allowing the obtainment of the first real detailed atomistic quantum-chemical transition-state structure (see figure) for the reaction catalyzed by this enzyme. The results obtained provide an atomic-level framework for the design of more potent and specific inhibitors for this important enzyme.
Sousa
Sérgio Filipe
SF
REQUIMTE, Departamento de Química, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre, 687, 4160-007 Porto, Portugal.
Fernandes
Pedro Alexandrino
PA
Ramos
Maria João
MJ
D002384:Catalysis; D018360:Crystallography, X-Ray; D051231:Farnesyltranstransferase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D008956:Models, Chemical; D011487:Protein Conformation; D013816:Thermodynamics
D051231:Farnesyltranstransferase