title: Ovarian stimulation in polycystic ovary syndrome patients: the role of body mass index.
abstract: In an attempt to examine whether body mass index (BMI) may influence IVF outcome in polycystic ovary syndrome (PCOS) patients undergoing ovarian stimulation with either gonadotrophin-releasing hormone (GnRH)-agonist (agonist group) or antagonist (antagonist group), 100 IVF cycles were studied: 35 in the agonist and 65 in the antagonist groups. In both agonist and antagonist groups, patients with BMI < or = 25 kg/m(2) had a significantly higher fertilization rate compared with patients with BMI > 25 kg/m(2) (P < 0.02 and P < 0.01, respectively). Lean patients (BMI < or = 25) undergoing ovarian stimulation using the GnRH-agonist, demonstrated the highest pregnancy rate. In conclusion, in this series of PCOS patients undergoing IVFembryo transfer cycles, ovarian stimulation utilizing the midluteal long GnRH-agonist suppressive protocol yielded a higher pregnancy rate in lean patients, probably due to its ability to lower the high basal LH milieu and its detrimental effect on oocyte quality and implantation potential.
authors.affiliation: Department of Obstetrics and Gynecology, Barzilai Medical Centre, Ashkelon, Israel. raoulo@barzi.health.gov.il
authors.forename: Raoul
authors.initials: R
authors.lastname: Orvieto
authors.forename: Ravit
authors.initials: R
authors.lastname: Nahum
authors.forename: Simion
authors.initials: S
authors.lastname: Meltcer
authors.forename: Roy
authors.initials: R
authors.lastname: Homburg
authors.forename: Jacob
authors.initials: J
authors.lastname: Rabinson
authors.forename: Eyal Y
authors.initials: EY
authors.lastname: Anteby
authors.forename: Jacob
authors.initials: J
authors.lastname: Ashkenazi
mesh_terms: D015992:Body Mass Index; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors; D006801:Humans; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D007987:Gonadotropin-Releasing Hormone