title: Highly enantioselective direct Michael addition of nitroalkanes to nitroalkenes catalyzed by amine-thiourea bearing multiple hydrogen-bonding donors.
abstract: A highly diastereoselective and enantioselective Michael addition of nitroalkanes to nitroalkenes has been achieved by chiral bifunctional amine-thiourea catalyst bearing multiple hydrogen-bonding donors. This catalytic system performs well over a broad scope of substrates, furnishing various 1,3-dinitro compounds in high diastereoselectivity (up to 98:2) and excellent enantioselectivity (up to 99% ee) under mild conditions. Multiple hydrogen bonding donors play a significant role in accelerating reactions, improving diastereoselectivities and enantioselectivities.
authors.affiliation: College of Chemistry and Molecular Sciences, Wuhan University, Hubei 430072, China.
authors.forename: Xiu-Qin
authors.initials: XQ
authors.lastname: Dong
authors.forename: Huai-Long
authors.initials: HL
authors.lastname: Teng
authors.forename: Chun-Jiang
authors.initials: CJ
authors.lastname: Wang