Allosteric switches: remote controls for proteins.
Long-distance service: Finding a selective small-molecule modulator for every domain of every human protein is a Herculean task. Wouldn't it be much easier to control the activity of any protein of choice by simply fusing it with a generally adaptable switch protein and controlling protein activity indirectly?
Berg
Thorsten
T
Department of Molecular Biology, Max Planck Institute of Biochemistry and Cluster for Integrated Protein Science Munich, Am Klopferspitz 18, 82152 Martinsried, Germany. berg@biochem.mpg.de
D000494:Allosteric Regulation; D006801:Humans; D011487:Protein Conformation; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism*
D011993:Recombinant Fusion Proteins