title: Haliclonin A, a new macrocyclic diamide from the sponge Haliclona sp.
abstract: Haliclonin A (1), a macrocyclic diamide of a novel skeletal class, was isolated from the marine sponge Haliclona sp. collected from Korean waters. The structure of this compound was determined using a combination of spectroscopic and chemical analyses. The new compound exhibited moderate cytotoxicity and antibacterial activity against diverse microbial strains.
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Seoul 151-742, Korea.
authors.forename: Kyoung Hwa
authors.initials: KH
authors.lastname: Jang
authors.forename: Gyoung Won
authors.initials: GW
authors.lastname: Kang
authors.forename: Ju-Eun
authors.initials: JE
authors.lastname: Jeon
authors.forename: Chaemin
authors.initials: C
authors.lastname: Lim
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Chung J
authors.initials: CJ
authors.lastname: Sim
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003959:Diamines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D047129:Haliclona / Q000737:chemistry*; D006801:Humans; D020014:K562 Cells; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D003959:Diamines; D047028:Macrocyclic Compounds; C540232:haliclonin A