title: Penicillamine-induced elastosis of the mucosal lip.
abstract: Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, "lumpy-bumpy"" or "bramble-bush"" morphologic changes of elastic fibers in the dermis are characteristic. Previous reports of these findings in normal-appearing skin and internal organs suggest a systemic elastolytic process. Here we report an unusual case of penicillamine-induced elastosis affecting the mucosa of the lip with characteristic histologic features.
authors.affiliation: Department of Internal Medicine, University of Utah Hospitals and Clinics, Salt Lake City, Utah, USA.
authors.forename: Bethany K H
authors.initials: BK
authors.lastname: Lewis
authors.forename: Peggy L
authors.initials: PL
authors.lastname: Chern
authors.forename: Mary Seabury
authors.initials: MS
authors.lastname: Stone
mesh_terms: D002614:Chelating Agents / Q000009:adverse effects*; D006801:Humans; D008047:Lip Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects*
chemical_list: D002614:Chelating Agents; D010396:Penicillamine