title: Cardiac recovery in a human non-heart-beating donor after extracorporeal perfusion: source for human heart donation?
abstract: Successful renal, liver and more recently lung transplantation using organs from non-heart-beating donors (NHBDs) has been reported. Regarding the heart, it has generally been assumed that warm ischemic insult would result in overwhelming and irreversible myocardial damage. We report recovery of cardiac function in a human NHBD by using extracorporeal perfusion 23 minutes after cardiorespiratory arrest. Successful cardiac resuscitation in the NHBD represents a potential source of increased donor organ supply for clinical heart transplantation.
authors.affiliation: Department of Cardiothoracic Surgery, Papworth Hospital, Papworth Everard, Cambridge, UK. ayyaz75@gmail.com
authors.forename: Ayyaz
authors.initials: A
authors.lastname: Ali
authors.forename: Paul
authors.initials: P
authors.lastname: White
authors.forename: Kumud
authors.initials: K
authors.lastname: Dhital
authors.forename: Marian
authors.initials: M
authors.lastname: Ryan
authors.forename: Steven
authors.initials: S
authors.lastname: Tsui
authors.forename: Stephen
authors.initials: S
authors.lastname: Large
mesh_terms: D005112:Extracorporeal Circulation; D005260:Female; D006321:Heart / Q000502:physiology*; D016027:Heart Transplantation; D006801:Humans; D008875:Middle Aged; D020127:Recovery of Function; D014019:Tissue Donors