title: Decreased viral load and symptoms of polyomavirus-associated chronic interstitial cystitis after intravesical cidofovir treatment.
abstract: Interstitial cystitis causes disabling bladder pain and is usually diagnosed in the absence of infection. We describe a patient with interstitial cystitis who had high urinary levels of polyomavirus that decreased dramatically after initiation of intravesical cidofovir treatment; the patient also showed substantial improvement in symptoms. Another patient had milder symptoms of cystitis and intermittent polyomavirus shedding. Polyomaviruses, particularly BK virus, may cause some cases of interstitial cystitis.
authors.affiliation: Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia. damon.eisen@mh.org.au
authors.forename: Damon P
authors.initials: DP
authors.lastname: Eisen
authors.forename: Ian R
authors.initials: IR
authors.lastname: Fraser
authors.forename: Linda M
authors.initials: LM
authors.lastname: Sung
authors.forename: Moira
authors.initials: M
authors.lastname: Finlay
authors.forename: Scott
authors.initials: S
authors.lastname: Bowden
authors.forename: Helen
authors.initials: H
authors.lastname: O'Connell
mesh_terms: D000283:Administration, Intravesical; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077404:Cidofovir; D018856:Cystitis, Interstitial / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D011120:Polyomavirus / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology; D014556:Urine / Q000821:virology*
chemical_list: D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir