title: Ceftriaxone-induced acute reversible encephalopathy in a patient treated for a urinary tract infection.
abstract: Encephalopathy is a rare side effect of third- and fourth-generation cephalosporins. Renal failure and previous disease of the central nervous system predispose to this neurotoxicity. We describe a case of encephalopathy with generalised triphasic waves in a patient with pre-existent cerebrovascular disease who was treated with ceftriaxone for a urinary tract infection. Early recognition of this complication is relevant given that ceftriaxone discontinuation reverted the neurological syndrome.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine of Porto, Hospital S. João, Porto, Portugal. rra_jr@yahoo.com
authors.forename: R
authors.initials: R
authors.lastname: Roncon-Albuquerque
authors.forename: I
authors.initials: I
authors.lastname: Pires
authors.forename: R
authors.initials: R
authors.lastname: Martins
authors.forename: R
authors.initials: R
authors.lastname: Real
authors.forename: G
authors.initials: G
authors.lastname: Sousa
authors.forename: P
authors.initials: P
authors.lastname: von Hafe
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D020258:Neurotoxicity Syndromes; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D002443:Ceftriaxone