title: This bud's for Vpu.
abstract: Successful viruses must overcome the body's immune defenses. In this issue of Cell Host & Microbe, Goffinet et al. (2009) provide evidence that the host protein CD317, the target of the HIV Vpu protein, is part of an ancient innate immune response directed against budding viruses.
authors.affiliation: Department of Internal Medicine and Microbiology & Immunology, University of Michigan, Ann Arbor, MI 48109, USA. klcollin@umich.edu
authors.forename: Kathleen L
authors.initials: KL
authors.lastname: Collins
mesh_terms: D015703:Antigens, CD / Q000276:immunology*; D058851:GPI-Linked Proteins; D006678:HIV / Q000276:immunology* / Q000472:pathogenicity*; D054298:Human Immunodeficiency Virus Proteins / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins / Q000037:antagonists & inhibitors* / Q000276:immunology*; D054334:Viral Regulatory and Accessory Proteins / Q000502:physiology*; D037521:Virulence Factors / Q000502:physiology*; D000074010:Bone Marrow Stromal Antigen 2; D000086082:Viroporin Proteins
chemical_list: D015703:Antigens, CD; D058851:GPI-Linked Proteins; D054298:Human Immunodeficiency Virus Proteins; D008562:Membrane Glycoproteins; D054334:Viral Regulatory and Accessory Proteins; D037521:Virulence Factors; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins