title: [Proton magnetic resonance spectroscopy in Asperger's syndrome: correlations with neuropsychological test scores].
abstract: OBJECTIVE
  It has been shown that autistic spectrum patients have impaired theory of mind (ToM) performance; however, no study has investigated the relationship between ToM performance and brain neurochemistry in these patients. The present study aimed to investigate the correlations between dorsolateral prefrontal cortex (DLPFC) and anterior cingulate cortex (ACC) N-acetyl-aspartate (NAA)/choline (Cho), NAA/creatine (Cr), and Cho/Cr values based on 1H magnetic resonance spectroscopy and ToM tests.
  
  
  METHODS
  The study sample included 13 adult, right-handed, Caucasian males with Asperger's syndrome (AS) (age range: 17-37 years) and 20 controls matched by age, gender, handedness, and Wechsler Adult Intelligence Scale, Revised (WAIS-R) full-scale IQ scores.
  
  
  RESULTS
  AS cases had significantly lower ToM performance. DLPFC NAA/Cho levels were inversely correlated to ToM scores (r = -0.738, P = 0.004). On the other hand, ToM performance improved as DLPFC Cho/Cr increased (r = 0.656, P = 0.015). ACC MRS variables were not significantly correlated with ToM performance in the AS group. No significant correlation was observed between ACC or DLPFC MRS variables and ToM performance in the control group.
  
  
  CONCLUSIONS
  Because NAA/Cho was inversely correlated with ToM performance and Cho/Cr was correlated with ToM performance, it can be suggested that the Cho level was related to better ToM test performance in the AS group. An increase in the Cho peak was associated with an increase in membrane breakdown or turnover. The Cho peak was also thought to reflect cellular density and astrocytosis. It is suggested that membrane turnover and astrocytosis might affect cognitive functioning.
authors.affiliation: ozgur.oner@yahoo.com
authors.forename: Ozgür
authors.initials: O
authors.lastname: Oner
authors.forename: Halise Devrimci
authors.initials: HD
authors.lastname: Ozgüven
authors.forename: Ferhunde
authors.initials: F
authors.lastname: Oktem
authors.forename: Banu
authors.initials: B
authors.lastname: Yağmurlu
authors.forename: Bora
authors.initials: B
authors.lastname: Baskak
authors.forename: Senay
authors.initials: S
authors.lastname: Olmez
authors.forename: Kerim
authors.initials: K
authors.lastname: Munir
mesh_terms: D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D020817:Asperger Syndrome / Q000503:physiopathology* / Q000523:psychology; D016022:Case-Control Studies; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005911:Gliosis / Q000150:complications; D006179:Gyrus Cinguli / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000737:chemistry*; D011522:Protons; D055815:Young Adult
chemical_list: D011522:Protons; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline