New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells.
The growth and metastasis of prostate cancer are regulated by prostate stroma through the tumor-stromal cell interactions. Small molecules that modulate the tumor-stromal cell interactions will be new anticancer drugs. In the course of our screening of the modulators, we isolated two new atpenins, NBRI23477 A (4) and B (5), from the fermentation broth of Penicillium atramentosum PF1420. Compounds 4 and 5 as well as atpenin A4 (1), A5 (2) and B (3) inhibited the growth of human prostate cancer DU-145 cells in the coculture with human prostate stromal cells more strongly than that of DU-145 cells alone.
Kawada
Manabu
M
Microbial Chemistry Research Center, Numazu Bio-Medical Research Institute, Shizuoka, Japan. kawadam@bikaken.or.jp
Momose
Isao
I
Someno
Tetsuya
T
Tsujiuchi
Goh
G
Ikeda
Daishiro
D
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D005285:Fermentation; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry / Q000378:metabolism; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011725:Pyridines / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D007202:Indicators and Reagents; C544402:NBR 123477 A; C544403:NBR 123477 B; D011725:Pyridines