Tissue regeneration as next-generation therapy for COPD--potential applications.
COPD is a major cause of chronic morbidity and mortality worldwide, and there is a need to develop more effective therapeutic strategies to replace specialized treatment such as lung transplantation. Recent studies suggest that recognition of apoptotic lung epithelial or endothelial cells may result in growth factors to stimulate cell replacement, and defects in these processes may contribute to the pathogenesis of COPD. Furthermore, recent animal and human studies have revealed that tissue-specific stem cells and bone marrow-derived cells contribute to lung tissue regeneration and protection, and thus administration of exogenous stem/progenitor cells or humoral factors responsible for activation of endogenous stem/progenitor cells may be a potent next-generation therapy for COPD.
Ohnishi
Shunsuke
S
Department of Regenerative Medicine and Tissue Engineering, National Cardiovascular Center Research Institute, Suita, Osaka, Japan. shunpou@hotmail.com
Nagaya
Noritoshi
N
D000818:Animals; D017209:Apoptosis; D016026:Bone Marrow Transplantation; D015444:Exercise; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012038:Regeneration; D044968:Regenerative Medicine; D040242:Risk Reduction Behavior; D016540:Smoking Cessation; D033581:Stem Cell Transplantation
D036341:Intercellular Signaling Peptides and Proteins