title: Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus.
abstract: Effective immunity is dependent on long-surviving memory T cells. Various memory subsets make distinct contributions to immune protection, especially in peripheral infection. It has been suggested that T cells in nonlymphoid tissues are important during local infection, although their relationship with populations in the circulation remains poorly defined. Here we describe a unique memory T cell subset present after acute infection with herpes simplex virus that remained resident in the skin and in latently infected sensory ganglia. These T cells were in disequilibrium with the circulating lymphocyte pool and controlled new infection with this virus. Thus, these cells represent an example of tissue-resident memory T cells that can provide protective immunity at points of pathogen entry.
authors.affiliation: Department of Microbiology and Immunology, The University of Melbourne, Melbourne Victoria, Australia.
authors.forename: Thomas
authors.initials: T
authors.lastname: Gebhardt
authors.forename: Linda M
authors.initials: LM
authors.lastname: Wakim
authors.forename: Liv
authors.initials: L
authors.lastname: Eidsmo
authors.forename: Patrick C
authors.initials: PC
authors.lastname: Reading
authors.forename: William R
authors.initials: WR
authors.lastname: Heath
authors.forename: Francis R
authors.initials: FR
authors.lastname: Carbone
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology; D005434:Flow Cytometry; D017950:Ganglia, Sensory / Q000166:cytology / Q000276:immunology* / Q000821:virology; D006561:Herpes Simplex / Q000276:immunology*; D007150:Immunohistochemistry; D007156:Immunologic Memory; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D018139:Simplexvirus / Q000276:immunology; D012867:Skin / Q000166:cytology / Q000276:immunology* / Q000821:virology; D016176:T-Lymphocyte Subsets / Q000276:immunology*