A mechanism for stochastic decision making by bacteria.
What mechanism underlies the induction of the lac operon? Expression from the lac operon is an all-or-none phenomenon. Recent work by Choi et al. combines single-molecule imaging of gene expression with single-cell induction measurements to develop a stochastic model describing the critical role of single lac-repressor molecules in induction.
Hensel
Zach
Z
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xiao
Jie
J
D001419:Bacteria / Q000166:cytology* / Q000235:genetics / Q000378:metabolism; D007763:Lac Operon; D026901:Membrane Transport Proteins / Q000378:metabolism; D008954:Models, Biological; D013269:Stochastic Processes
D026901:Membrane Transport Proteins