title: Performance evaluation of a particle-enhanced turbidimetric cystatin C assay on the Abbott ci8200 analyzer.
abstract: OBJECTIVE
  Glomerular filtration rate (GFR) is widely accepted as the best overall measure of kidney function. Cystatin C is a novel endogenous GFR marker that has been shown to be superior to creatinine for estimation of GFR in several studies. There is a need for cystatin C assays adapted to routine chemistry instrument to minimize turnaround times and allowing 24 h/day availability.
  
  
  METHODS
  We have evaluated a new cystatin C assay developed for Architect cSystem (Abbott Laboratories, Abbott Park, IL, USA).
  
  
  RESULTS
  The cystatin C assay showed good agreement with the corresponding assay from Dade Behring (Deerfield, IL, USA). The assay has a very low total imprecision and a good linearity.
  
  
  CONCLUSIONS
  The new cystatin C assay is an interesting alternative to current cystatin C assays. On an Architect cSystem the assay can be performed with the same turnaround times and availability as creatinine.
authors.affiliation: Department of Clinical Chemistry and Pharmacology, University Hospital, Uppsala, Sweden.
authors.forename: Mats
authors.initials: M
authors.lastname: Flodin
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
mesh_terms: D001681:Biological Assay / Q000379:methods*; D055316:Cystatin C / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D009391:Nephelometry and Turbidimetry / Q000379:methods*
chemical_list: D055316:Cystatin C