title: Biotin-avidin as a protease-responsive cap system for controlled guest release from colloidal mesoporous silica.
abstract: Tell your guests when it's time to go: When avidin caps are attached to biotinylated colloidal mesoporous silica, the four subunits of the protein avidin can each bind to a biotin moiety attached to the surface (see picture). The resulting material is a promising candidate for the design of smart detergents or drug-delivery systems. The caps can be opened to release guest molecules by controlled enzymatic hydrolysis of the protein.
authors.affiliation: Department of Chemistry and Biochemistry and Center for NanoScience (CeNS), University of Munich (LMU), Butenandtstrasse 11 (E), 81377 Munich, Germany.
authors.forename: Axel
authors.initials: A
authors.lastname: Schlossbauer
authors.forename: Johann
authors.initials: J
authors.lastname: Kecht
authors.forename: Thomas
authors.initials: T
authors.lastname: Bein
mesh_terms: D001360:Avidin / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry*; D003102:Colloids; D016503:Drug Delivery Systems; D055767:Immobilized Proteins / Q000737:chemistry; D010447:Peptide Hydrolases / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003102:Colloids; D055767:Immobilized Proteins; D001360:Avidin; D001710:Biotin; D012822:Silicon Dioxide; D010447:Peptide Hydrolases