title: New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1.
abstract: In the course of our screening program for novel metabolites from tunicate-derived fungi, novel sesquiterpenoids, named JBIR-27 (1) and -28 (2), together with known sporogen-AO1 and phomenone, were isolated from the culture broth of Penicillium sp. SS080624SCf1. The structures of 1 and 2 were determined to be eremophilane analogs on the basis of extensive NMR and MS analyses. Sporogen-AO1, phomenone and 2 showed cytotoxicity against human cervical carcinoma cell line HeLa at IC(50) values of 8.3, 19 and 92 microM, respectively, whereas 1 was inactive at a concentration of 80 microM.
authors.affiliation: Biomedicinal Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan.
authors.forename: Keiichiro
authors.initials: K
authors.lastname: Motohashi
authors.forename: Junko
authors.initials: J
authors.lastname: Hashimoto
authors.forename: Shigeki
authors.initials: S
authors.lastname: Inaba
authors.forename: Shams Tabrez
authors.initials: ST
authors.lastname: Khan
authors.forename: Hisayuki
authors.initials: H
authors.lastname: Komaki
authors.forename: Aya
authors.initials: A
authors.lastname: Nagai
authors.forename: Motoki
authors.initials: M
authors.lastname: Takagi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Shin-ya
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D003470:Culture Media; D004271:DNA, Fungal / Q000096:biosynthesis / Q000378:metabolism; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry* / Q000378:metabolism*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D014561:Urochordata / Q000382:microbiology*
chemical_list: D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D004271:DNA, Fungal; C544404:JBIR-27; C544405:JBIR-28; D012717:Sesquiterpenes