title: Invasion of the alveolar-capillary barrier by Aspergillus spp.: therapeutic and diagnostic implications for immunocompromised patients with invasive pulmonary aspergillosis.
abstract: Aspergillus spp. are leading causes of morbidity and mortality in immunocompromised patients. This review provides an overview of host defenses, the mechanisms by which the alveolar-capillary barrier is breeched by Aspergillus, and the implications for diagnosis and treatment of patients with invasive pulmonary aspergillosis.
authors.affiliation: The University of Manchester, Manchester, UK. william.hope@manchester.ac.uk
authors.forename: William W
authors.initials: WW
authors.lastname: Hope
mesh_terms: D001230:Aspergillus / Q000254:growth & development* / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D055744:Invasive Pulmonary Aspergillosis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D008168:Lung / Q000276:immunology / Q000382:microbiology / Q000473:pathology