Lost in transcription--inhibition of RNA polymerase.
Form and function: The natural product myxopyronin A provides the key to understanding the inhibition of bacterial RNA polymerase and should spark new ideas for the design of new antibiotics against tuberculosis and other infectious diseases.
Haebich
Dieter
D
Bayer Schering Pharma AG, Medicinal Chemistry Europe, 42096 Wuppertal, Germany. dieter.haebich@bayerhealthcare.com
von Nussbaum
Franz
F
D000904:Antibiotics, Antitubercular / Q000737:chemistry* / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry* / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D014158:Transcription, Genetic / Q000187:drug effects*
D000904:Antibiotics, Antitubercular; D004791:Enzyme Inhibitors; D007783:Lactones; C040322:myxopyronin A; D012321:DNA-Directed RNA Polymerases