Histiocytic erythema multiforme.
Erythema multiforme is histologically characterized by liquefactive degeneration along the dermal-epidermal junction, necrotic keratinocytes and a lymphocytic infiltrate. We report a 10-year-old boy with recurrent erythema multiforme major of undetermined etiology with unusual histologic findings. A skin biopsy taken at day 2 of his eruption revealed histologic features otherwise characteristic of erythema multiforme, but mediated instead by a CD68-positive infiltrate, resembling cutaneous Kikuchi's disease. To the best of our knowledge this is the first reported case of 'histiocytic' erythema multiforme.
Sebastian
Anita
A
Department of Pathology, Hahnemann University Hospital/Drexel College of Medicine, Philadelphia, PA, USA.
Patterson
Connor
C
Zaenglein
Andrea L
AL
Ioffreda
Michael D
MD
Helm
Klaus F
KF
D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002648:Child; D004892:Erythema Multiforme / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D016756:Immunoglobulins, Intravenous; C067980:CD68 antigen, human; D000097382:CD68 Molecule