Synthesis and property of a novel calcium phosphate cement.
The beta-cyclodextrins (beta-CDs) and amorphous calcium phosphate were used to prepare a novel calcium phosphate cement (CPC) after mechanochemical activation. Under the mechanochemical treatment, hydrogen bonding formed between beta-CD molecules, which induced strong interaction among beta-CD molecules in aqueous solution, thus conferring good antiwashout property for CPC. After mechanochemical treatment, the solubility of beta-CD was increased and so beta-CD showed different behaviors within and on the outer surface of CPC. During the setting process, when beta-CD was injected it flowed to the surface of CPC, forming a beta-CD film on the surface of CPC; inside the cement, the hydration reaction of calcium phosphates was not affected. Moreover, the antiwashout CPC with beta-CD also showed good mechanical setting, rheological properties, and injectability. The novel CPC was supposed to be developed as a good injectable bone substitute material in the clinical application.
Yu
Tao
T
Key Laboratory of Specially Functional Materials of the Ministry of Education and School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China. yt04post@yahoo.com.cn
Ye
Jiandong
J
Wang
Yingjun
Y
D001672:Biocompatible Materials / Q000737:chemistry*; D001843:Bone Cements / Q000138:chemical synthesis*; D018786:Bone Substitutes; D002130:Calcium Phosphates / Q000737:chemistry*; D019245:Compressive Strength; D008855:Microscopy, Electron, Scanning / Q000379:methods; D011208:Powders; D012212:Rheology / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013997:Time Factors; D014783:Viscosity; D014961:X-Ray Diffraction / Q000379:methods; D047392:beta-Cyclodextrins / Q000737:chemistry
D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D011208:Powders; D047392:beta-Cyclodextrins; C020243:calcium phosphate; C031215:betadex