Feline intestinal T-cell lymphoma: assessment of morphologic and kinetic features in 30 cases.
In this study, 30 feline intestinal T-cell lymphomas (ITCLs) from 77 cats with gastrointestinal lymphoma were evaluated. Neoplastic lesions were composed predominantly of small (n = 21) or medium to large (n = 9) anaplastic cells. Different patterns of tumor growth were observed. A starry-sky pattern was evident in 7 cases (23.3%), fibrosis in 18 cases (60%), and neovascularization in 19 cases (63.3%). The cell proliferation index (assessed by MIB1 [mindbomb homolog 1] immunohistochemistry) ranged from 0.21% to 66.91%. Mean MIB1 index was 3.49% within the first 33rd percentile, 18.31% within the second 33rd percentile, and 40.16% within the third 33rd percentile (P < 0.000001). Microscopic and kinetic features provided evidence that ITCL in cats exhibits a spectrum in cytological composition and growth patterns that could putatively reflect differences in biologic behavior.
Cesari
Alessandro
A
Pathology Division of the Department of Veterinary Public Health and Animal Pathology, Faculty of Veterinary Medicine, University of Bologna, Ozzano dell'Emilia, Bologna, Italy.
Bettini
Giuliano
G
Vezzali
Enrico
E
D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D007414:Intestinal Neoplasms / Q000473:pathology / Q000662:veterinary*; D016399:Lymphoma, T-Cell / Q000473:pathology / Q000662:veterinary*; D008297:Male; D012189:Retrospective Studies