[Somatic comorbidities in irritable bowel syndrome: fibromyalgia, chronic fatigue syndrome, and interstitial cystitis].
Fibromyalgia, chronic fatigue syndrome, and interstitial cystitis frequently overlap with irritable bowel syndrome (IBS). There is a positive correlation between the incidence of these comorbidities and increased health care seeking, reduction in quality of life, and higher levels of mood disorders, which raises the question of a common underlying pathophysiology. A possible central hypersensitization disorder seems to be particularly involved in the dysfunction of bidirectional neural pathways and viscerovisceral cross-interactions within the CNS, thus explaining these many extraintestinal manifestations in IBS.
Mathieu
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Clinique Universitaire d'Hépato-Gastroentérologie, Pôle DIGIDUNE, Centre Hospitalo-universitaire de Grenoble, France. NMathieu@chu-grenoble.fr
D015897:Comorbidity; D018856:Cystitis, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D003937:Diagnosis, Differential; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D005356:Fibromyalgia / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D010342:Patient Acceptance of Health Care