Use of the hollow fibre assay for studies of tumor neovasculature.
In vivo preclinical assays are required to screen potential agents that target the tumor vasculature. Here, a hollow fibre-based assay for the quantification of neovasculature in the presence or absence of an agent that potentially targets tumor neovasculature is described. The neovasculature is developed as a consequence of the presence of tumor cells encapsulated in hollow fibres, which are transplanted subcutaneously in the dorsal flanks of mice.
Shnyder
Steven D
SD
Institute of Cancer Therapeutics, University of Bradford, Bradford, UK.
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D045744:Cell Line, Tumor; D051379:Mice; D009369:Neoplasms / Q000098:blood supply*; D009389:Neovascularization, Pathologic; D019736:Prostheses and Implants; D046509:Tissue Culture Techniques