title: Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria.
abstract: It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondrial DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P=0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P=0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P=0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.
authors.affiliation: Division of Nephrology, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
authors.forename: Jung Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Hansoo
authors.initials: H
authors.lastname: Park
authors.forename: Young Seok
authors.initials: YS
authors.lastname: Ju
authors.forename: Minhye
authors.initials: M
authors.lastname: Kwak
authors.forename: Jong Il
authors.initials: JI
authors.lastname: Kim
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Oh
authors.forename: Jeong Sun
authors.initials: JS
authors.lastname: Seo
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D003430:Cross-Sectional Studies; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial