title: Phenotypic characteristics and pathogenic ability across distinct morphotypes of Burkholderia pseudomallei DT.
abstract: Burkholderia pseudomallei DT is unusual as it exhibits six distinct colony morphotypes. Types III and V show stronger motility, whereas type VI exhibits the highest levels of bacterial association with peritoneal exudate cells. Although the bacterial loads in the organs are not significantly different for infections by the six distinct morphotypes, higher mortality (100% and 89%, respectively) and larger areas of abnormal liver debris (20.6% and 22.4%, respectively) are found with types I- and III-infected mice compared to the others. These morphotypes sometimes undergo switching to a mucoid type in the body of mice, but the reverse has never been observed.
authors.affiliation: Section of Infectious Disease, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
authors.forename: Yao-Shen
authors.initials: YS
authors.lastname: Chen
authors.forename: Hsi-Hsun
authors.initials: HH
authors.lastname: Lin
authors.forename: Chih-Chang
authors.initials: CC
authors.lastname: Hung
authors.forename: Jung-Jung
authors.initials: JJ
authors.lastname: Mu
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Hsiao
authors.forename: Ya-Lei
authors.initials: YL
authors.lastname: Chen
mesh_terms: D000825:Animal Structures / Q000382:microbiology; D000818:Animals; D016957:Burkholderia pseudomallei / Q000472:pathogenicity* / Q000502:physiology*; D005122:Exudates and Transudates / Q000382:microbiology; D008099:Liver / Q000473:pathology; D008124:Locomotion; D008554:Melioidosis / Q000382:microbiology* / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010533:Peritoneal Lavage; D016019:Survival Analysis