Swimming exercise at weaning improves glycemic control and inhibits the onset of monosodium L-glutamate-obesity in mice.
Swimming exercises by weaning pups inhibited hypothalamic obesity onset and recovered sympathoadrenal axis activity, but this was not observed when exercise training was applied to young adult mice. However, the mechanisms producing this improved metabolism are still not fully understood. Low-intensity swimming training started at an early age and was undertaken to observe glycemic control in hypothalamic-obese mice produced by neonatal treatment with monosodium l-glutamate (MSG). Whereas MSG and control mice swam for 15 min/day, 3 days a week, from the weaning stage up to 90 days old, sedentary MSG and normal mice did not exercise at all. After 14 h of fasting, animals were killed at 90 days of age. Perigonadal fat accumulation was measured to estimate obesity. Fasting blood glucose and insulin concentrations were also measured. Fresh isolated pancreatic islets were used to test glucose-induced insulin release and total catecholamine from the adrenal glands was measured. Mice were also submitted to intraperitoneal glucose tolerance test. MSG-obese mice showed fasting hyperglycemia, hyperinsulinemia, and glucose intolerance. Severe reduction of adrenal catecholamines content has also been reported. Besides, the inhibition of fat tissue accretion, exercise caused normalization of insulin blood levels and glycemic control. The pancreatic islets of obese mice, with impaired glucose-induced insulin secretion, were recovered after swimming exercises. Adrenal catecholamine content was increased by swimming. Results show that attenuation of MSG-hypothalamic obesity onset is caused, at least in part, by modulation of sympathoadrenal axis activity imposed by early exercise, which may be associated with subsequent glucose metabolism improvement.
Andreazzi
A E
AE
Laboratory of Secretion Cell Biology, Department of Cell Biology and Genetics, State University of Maringá, PR, Brazil.
Scomparin
D X
DX
Mesquita
F P
FP
Balbo
S L
SL
Gravena
C
C
De Oliveira
J C
JC
Rinaldi
W
W
Garcia
R M G
RM
Grassiolli
S
S
Mathias
P C F
PC
D000818:Animals; D000833:Animals, Suckling; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005951:Glucose Tolerance Test; D008297:Male; D051379:Mice; D009765:Obesity / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D010805:Physical Conditioning, Animal / Q000502:physiology; D012970:Sodium Glutamate; D013550:Swimming / Q000502:physiology*; D014886:Weaning
D001786:Blood Glucose; D012970:Sodium Glutamate