Total synthesis of hopeahainol A and hopeanol.
Similar, but different: Possessing almost the same but not identical structures, the recently discovered natural products hopeahainol A (1) and hopeanol (2) exhibit important but differing biological properties (see structures). Their first total synthesis has now been achieved through a series of novel cascade reactions and skeletal rearrangements.
Nicolaou
K C
KC
Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research, 11 Biopolis Way, The Helios Block, 03-08, Singapore 138667, Singapore. kcn@scripps.edu
Wu
T Robert
TR
Kang
Qiang
Q
Chen
David Y-K
DY
D053958:Dipterocarpaceae / Q000737:chemistry / Q000378:metabolism; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry
D006576:Heterocyclic Compounds, 4 or More Rings; D010636:Phenols; C526863:hopeahainol A; C540974:hopeanol