title: Pagetoid spread to oral mucosa from submandibular gland salivary duct carcinoma: a case report.
abstract: Salivary duct carcinoma is a high-grade malignant tumor arising predominantly in the major salivary glands. We describe herein a rare presentation of salivary duct carcinoma arising in the submandibular gland and showing pagetoid spread to the oral mucosa. A 46-year-old man was admitted with a 2-year history of swelling in the floor of the mouth. Resection of the submandibular gland tumor was followed by mucosal biopsy around the aperture of the right Wharton's duct. The tumor recurred in the oral mucosa with pagetoid spread and extended widely in the oral cavity for the following 10 years, despite chemo- and radiotherapy. Mucosal spread, although a relatively remote possibility, can occur in the setting of salivary duct carcinoma.
authors.affiliation: Department of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-0033 Japan. ompyk@hotmail.com
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Uozaki
authors.forename: Shinji
authors.initials: S
authors.lastname: Itoyama
authors.forename: Hideto
authors.initials: H
authors.lastname: Saijo
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takato
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
mesh_terms: D044584:Carcinoma, Ductal / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology*; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D018987:Salivary Ducts / Q000473:pathology; D013363:Submandibular Gland / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000473:pathology*