title: Stereodivergent access to polyhydroxylated 10-azabicyclo[4.3.1]decanes as new calystegine analogues.
abstract: A rapid and stereodivergent access to polyhydroxylated 10-azabicyclo[4.3.1]decanes as new calystegine analogues by way of a double benzotriazolyl/carbon nucleophile exchange followed by a ring-closing metathesis was achieved. Preliminary evaluation of the new compounds as glucocerebrosidase inhibitors was also performed.
authors.affiliation: Institut de Chimie Organique et Analytique, Université d'Orléans-CNRS UMR 6005, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Chagnault
authors.forename: Philippe
authors.initials: P
authors.lastname: Compain
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Lewinski
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ikeda
authors.forename: Naoki
authors.initials: N
authors.lastname: Asano
authors.forename: Olivier R
authors.initials: OR
authors.lastname: Martin
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry*; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D014326:Tropanes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D014326:Tropanes; C055033:calystegin