title: Review: cellular metabolism: contribution to postoperative adhesion development.
abstract: Postoperative adhesions are a significant source of morbidity, including contributions to pelvic pain, bowel obstruction, and infertility. While the mechanisms of postoperative adhesion development are complex and incompletely understood, hypoxia appears to trigger a cascade of intracellular responses involving hypoxia-inducible factors, lactate, reactive oxygen species, reactive nitrogen species, and insulin-like growth factors that results in manifestation of the adhesion phenotype. Thus, substantial evidence exists to implicate the direct role of cellular metabolism in wound repair and adhesion development.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
authors.forename: Valerie I
authors.initials: VI
authors.lastname: Shavell
authors.forename: Ghassan M
authors.initials: GM
authors.lastname: Saed
authors.forename: Michael P
authors.initials: MP
authors.lastname: Diamond
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000473:pathology; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D000267:Tissue Adhesions / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*