title: Genome-assisted prediction of a quantitative trait measured in parents and progeny: application to food conversion rate in chickens.
abstract: Accuracy of prediction of yet-to-be observed phenotypes for food conversion rate (FCR) in broilers was studied in a genome-assisted selection context. Data consisted of FCR measured on the progeny of 394 sires with SNP information. A Bayesian regression model (Bayes A) and a semi-parametric approach (Reproducing kernel Hilbert Spaces regression, RKHS) using all available SNPs (p = 3481) were compared with a standard linear model in which future performance was predicted using pedigree indexes in the absence of genomic data. The RKHS regression was also tested on several sets of pre-selected SNPs (p = 400) using alternative measures of the information gain provided by the SNPs. All analyses were performed using 333 genotyped sires as training set, and predictions were made on 61 birds as testing set, which were sons of sires in the training set. Accuracy of prediction was measured as the Spearman correlation (_r(S)) between observed and predicted phenotype, with its confidence interval assessed through a bootstrap approach. A large improvement of genome-assisted prediction (up to an almost 4-fold increase in accuracy) was found relative to pedigree index. Bayes A and RKHS regression were equally accurate (_r(S)) = 0.27) when all 3481 SNPs were included in the model. However, RKHS with 400 pre-selected informative SNPs was more accurate than Bayes A with all SNPs.
authors.affiliation: Department of Dairy Science, University of Wisconsin, Madison, WI 53706, USA. gonzalez.oscar@inia.es
authors.forename: Oscar
authors.initials: O
authors.lastname: González-Recio
authors.forename: Daniel
authors.initials: D
authors.lastname: Gianola
authors.forename: Guilherme Jm
authors.initials: GJ
authors.lastname: Rosa
authors.forename: Kent A
authors.initials: KA
authors.lastname: Weigel
authors.forename: Andreas
authors.initials: A
authors.lastname: Kranis
mesh_terms: D000818:Animals; D001947:Breeding; D002645:Chickens / Q000235:genetics*; D005260:Female; D016678:Genome; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide; D019655:Quantitative Trait, Heritable