[Viral pathogens of acute lower respiratory tract infection in hospitalized children from East Guangdong of China].
OBJECTIVE
To investigate the viral pathogens of acute lower respiratory tract infection (ALRTI) in hospitalized children from East Guangdong Province of China and the relationship of the pathogens with age and seasons.


METHODS
The nasopharyngeal aspirates samples obtained from 345 hospitalized children with ALRTI were investigated for respiratory syncytial virus (RSV), human bocavirus (HBoV), human metapneumovirus (hMPV), influenza virus types A and B, rhinovirus, parainfluenza virus types 1 and 3 and adenovirus by PCR.


RESULTS
Viral pathogens were detected in 178 patients (51.6%). RSV was the most frequent (19.3%). Novel viruses hMPV (3.2%) and HBoV (3.2%) were found. A highest detection rate (61.9%) of virus was found between January to March. The infants aged 1 to 6 months showed a higher detection rate (71.3%) of virus than the other age groups. The detection rate of viral pathogens was 72.6% in children with bronchiolitis, followed by asthmatic bronchitis (70.0%) and bronchial pneumonia (44.6%).


CONCLUSIONS
RSV remained the leading viral pathogens in children with ALRTI in East Guangdong of China. Novel viruses HBoV and hMPV were also important pathogens. The detection rate of viral pathogens was associated with seasonal changes and age. Different respiratory infectious diseases had different viral detection rates, with highest detection rate in bronchiolitis cases.
Ou
Shao-Yang
SY
Department of Pediatrics, People's Hospital of Jieyang, Jieyang, Guangdong 522000, China.
Lin
Guang-Yu
GY
Wu
Yang
Y
Lu
Xue-Dong
XD
Lin
Chuang-Xing
CX
Zhou
Ren-Bin
RB
D000208:Acute Disease; D000256:Adenoviridae / Q000302:isolation & purification; D002673:Child, Hospitalized; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D029121:Metapneumovirus / Q000302:isolation & purification; D009305:Nasopharynx / Q000821:virology*; D009975:Orthomyxoviridae / Q000302:isolation & purification; D018113:Respiratory Syncytial Virus, Human / Q000302:isolation & purification; D012141:Respiratory Tract Infections / Q000821:virology*; D012229:Rhinovirus / Q000302:isolation & purification; D012621:Seasons