Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD).
Traditionally, neuropsychological deficits due to Sickle Cell Disease (SCD) have been understudied in adults. We have begun to suspect, however, that symptomatic and asymptomatic Cerebrovascular Events (CVE) may account for an alarming number of deficits in this population. In the current brief review, we critically evaluated the pediatric and adult literatures on the neurocognitive effects of SCD. We highlighted the studies that have been published on this topic and posit that early detection of CVE via neurocognitive testing, neuropsychiatric evaluations, and neuroimaging may significantly reduce adult cognitive and functional morbidities.
Edwards
Christopher L
CL
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. cledwa00@acpub.duke.edu
Raynor
Renee Dunn
RD
Feliu
Miriam
M
McDougald
Camela
C
Johnson
Stephanie
S
Schmechel
Donald
D
Wood
Mary
M
Bennett
Gary G
GG
Saurona
Patrick
P
Bonner
Melanie
M
Wellington
Chante'
C
DeCastro
Laura M
LM
Whitworth
Elaine
E
Abrams
Mary
M
Logue
Patrick
P
Edwards
Lekisha
L
Martinez
Salutario
S
Whitfield
Keith E
KE