One-pot synthesis of cyclic antifreeze glycopeptides.
The first cyclic glycopeptides exhibiting significant antifreeze activity by forming hexagonal-bipyramidal ice crystals, denoted cyclic antifreeze glycopeptides (cyclic AFGPs), were constructed by a one-pot synthesis based on the controlled cyclization reaction of pre-formed small linear glycopeptides.
Hachisu
Masakazu
M
Laboratory of Advanced Chemical Biology, Graduate School of Advanced Life Science, and Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, Sapporo, Japan.
Hinou
Hiroshi
H
Takamichi
Manabu
M
Tsuda
Sakae
S
Koshida
Shuhei
S
Nishimura
Shin-Ichiro
S
D021301:Antifreeze Proteins / Q000138:chemical synthesis*; D002942:Circular Dichroism; D010456:Peptides, Cyclic / Q000138:chemical synthesis*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D021301:Antifreeze Proteins; D010456:Peptides, Cyclic