title: Integrin switching modulates adhesion dynamics and cell migration.
abstract: When cells are stimulated to move, for instance during development, wound healing or angiogenesis, they undergo changes in the turnover of their cell-matrix adhesions. This is often accompanied by alterations in the expression profile of integrins-the extracellular matrix receptors that mediate anchorage within these adhesions. Here, we discuss how a shift in expression between two different types of integrins that bind fibronectin can have dramatic consequences for cell-matrix adhesion dynamics and cell motility.
authors.affiliation: Leiden Amsterdam Center for Drug Research, Leiden University, Netherlands.
authors.forename: Hoa
authors.initials: H
authors.lastname: Truong
authors.forename: Erik H J
authors.initials: EH
authors.lastname: Danen
mesh_terms: D002448:Cell Adhesion / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D016023:Integrins / Q000502:physiology*
chemical_list: D016023:Integrins