A convenient synthesis of p-substituted 1-arylsulfonyl-pyrrolidin-2-ones.
A convenient and novel method of cyclisation of 4-(4-substituted-phenylsulfonamido)-butanoic acids to their corresponding p-substituted 1-arylsulfonyl-pyrrolidin-2-ones was achieved by using polyphosphate ester (PPE). The reaction times were considerably reduced, with an increase in yields, when PPE was used in combination with a catalytic amount of pyridine.
Zareef
Muhammad
M
Department of Chemistry, University of Gujrat, Gujrat, Pakistan. mzareef71@yahoo.com
Iqbal
Rashid
R
Khan
Khalid M
KM
Zaidi
Javid H
JH
Zia-Ullah
Arfan
Muhammad
M
D015394:Molecular Structure; D011122:Polyphosphates / Q000737:chemistry; D011760:Pyrrolidinones / Q000138:chemical synthesis*
D011122:Polyphosphates; D011760:Pyrrolidinones