Posterior segment involvement in Korean patients with HLA-B27-associated uveitis.
OBJECTIVE
To compare clinical characteristics and visual prognosis between HLA-B27-associated uveitis patients with and without posterior segment involvement.


METHODS
Medical records of 78 patients with HLA-B27-associated uveitis were retrospectively analyzed.


RESULTS
Neither demographic nor clinical characteristics were associated with the presence of posterior segment involvement. In patients with posterior segment involvement, more aggressive therapeutic strategies, including immunomodulatory therapy, were frequently required. The rate of visual acuity 20/50 or worse was higher in patients with posterior involvement than in patients without posterior involvement.


CONCLUSIONS
Patients with posterior segment involvement showed worse visual outcome than patients without posterior involvement.
Kim
Sang Jin
SJ
Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea.
Chung
Hum
H
Yu
Hyeong Gon
HG
D000293:Adolescent; D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005128:Eye Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D015796:HLA-B27 Antigen / Q000276:immunology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007723:Korea; D008269:Macular Edema / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D031300:Retinal Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D012189:Retrospective Studies; D015866:Uveitis, Posterior / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D014792:Visual Acuity / Q000502:physiology; D014822:Vitreous Body / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D055815:Young Adult
D005938:Glucocorticoids; D015796:HLA-B27 Antigen; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D001379:Azathioprine