title: Unusual metastases from extremity soft tissue sarcomas.
abstract: The most common metastatic route for extremity soft-tissue sarcomas is via the venous system to the lungs. Metastases to other sites such as the brain, liver, and soft tissue distant from the primary tumor are rare. A tumor registry, prospectively kept since 1986, was reviewed for unusual metastatic spread. Of 3671 tumors, 346 high-grade extremity soft-tissue sarcomas were evaluated. A total of 15 patients (4.3%) presented with initial recurrence of disease that was extrapulmonary and distant from the site of the primary tumor. Four of these patients (27%) were successfully treated for their recurrence. Based on these findings, a different strategy for follow-up of patients after treatment of a high-grade extremity soft-tissue sarcoma is suggested.
authors.affiliation: Department of Orthopedics, University of Colorado Health Sciences Center, 4200 E 9th Ave, Mail Stop B202, Denver, CO 80262, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Ryzewicz
authors.forename: Heather A
authors.initials: HA
authors.lastname: McLoughlin
authors.forename: Curt
authors.initials: C
authors.lastname: Freudenberger
authors.forename: Allison
authors.initials: A
authors.lastname: Williams
authors.forename: Bennie
authors.initials: B
authors.lastname: Lindeque
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003120:Colorado / Q000453:epidemiology; D005121:Extremities; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D035583:Rare Diseases; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D012509:Sarcoma / Q000453:epidemiology* / Q000556:secondary*; D055815:Young Adult