Complement-mediated tumour growth: implications for cancer nanotechnology and nanomedicines.
The recent unexpected observation that complement activation helps tumour growth and progression has an important bearing on the future development of cancer nanomedicines for site-specific tumour targeting as these entities are capable of triggering complement. These issues are discussed and suggestions are provided for future design and development of safer and effective cancer nanomedicines.
Moghimi
S M
SM
Andresen
T L
TL
D048708:Cell Growth Processes / Q000502:physiology; D003165:Complement System Proteins / Q000502:physiology*; D018450:Disease Progression; D006801:Humans; D050997:Nanomedicine / Q000379:methods / Q000639:trends*; D036103:Nanotechnology / Q000379:methods / Q000639:trends*; D009369:Neoplasms / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000628:therapy*
D003165:Complement System Proteins