[Brain injury marker S100B can reduce the use of computer tomography in minor head injuries--secondary publication].
The risk of acute intracranial complications after minor head injury (MHI) is low. Despite this, computed tomography (CT) is generally recommended with clinical observation as a secondary option. Both options have disadvantages. Clinical studies have shown the potential advantages of using the biomarker S100B. The specificity of S100B is low, but a high sensitivity for brain damage results in a clinically useful, high negative predictive value (NPV). Integration of S100B into existing management routines can reduce the need for CT scans or admission by over 30%.
Springborg
Jtiaocnob Bertram
JB
Neurokirurgisk Klinik, Rigshospitalet, DK-2100 København Ø. jacob.springborg@rh.regionh.dk
Undén
Johan
J
Ingebrigtsen
Tor
T
Romner
Bertil
B
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002648:Child; D017046:Cost Savings; D006259:Craniocerebral Trauma / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D009414:Nerve Growth Factors / Q000097:blood*; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000191:economics
D015415:Biomarkers; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human