title: Peroxiredoxin I is overexpressed in oncocytic lesions of salivary glands.
abstract: BACKGROUND
  Oncocytic lesions, particularly frequent in the salivary glands, are characterized by cells with an atypical accumulation of mitochondria. This accumulation has been recognized as a compensatory mechanism to intrinsic functional defects of these organelles, resulting in energy production impairment and increased generation of reactive oxygen species (ROS), including hydrogen peroxide (H(2)O(2)). Peroxiredoxin I (Prx I) is a H(2)O(2) scavenging protein and the expression of its yeast homolog was reported to be influenced by mitochondrial function.
  
  
  METHODS
  In this study, we evaluated Prx I expression in oncocytic lesions of salivary glands by immunohistochemistry.
  
  
  RESULTS
  Our results showed that Prx I is overexpressed in oncocytes regardless of the salivary gland lesion where they appear.
  
  
  CONCLUSIONS
  These results suggest that Prx I expression in oncocytes is related to its ability to decompose mitochondrial-derived H(2)O(2) and that it could provide to the cells a protective role in an environment that, by continuously producing potential DNA-damaging ROS, predisposes to genome instability and cellular transformation.
authors.affiliation: Department of Oral Pathology, São Leopoldo Mandic Research Center, SP, Brazil. demasiap@gmail.com
authors.forename: Ana P D
authors.initials: AP
authors.lastname: Demasi
authors.forename: Cristiane
authors.initials: C
authors.lastname: Furuse
authors.forename: Albina
authors.initials: A
authors.lastname: Altemani
authors.forename: José L C
authors.initials: JL
authors.lastname: Junqueira
authors.forename: Paulo R G
authors.initials: PR
authors.lastname: Oliveira
authors.forename: Vera C
authors.initials: VC
authors.lastname: Araújo
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology; D000235:Adenolymphoma / Q000201:enzymology / Q000473:pathology; D018249:Adenoma, Oxyphilic / Q000201:enzymology / Q000473:pathology; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D018277:Carcinoma, Mucoepidermoid / Q000201:enzymology / Q000473:pathology; D016166:Free Radical Scavengers / Q000032:analysis; D015971:Gene Expression Regulation, Enzymologic; D016586:Granular Cell Tumor / Q000201:enzymology / Q000473:pathology; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis; D006965:Hyperplasia; D008247:Lysosomes / Q000473:pathology; D008679:Metaplasia; D008928:Mitochondria / Q000473:pathology; D024862:Oxyphil Cells / Q000201:enzymology* / Q000473:pathology; D054464:Peroxiredoxins / Q000032:analysis*; D017382:Reactive Oxygen Species / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000201:enzymology / Q000473:pathology; D012469:Salivary Glands / Q000201:enzymology* / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins