title: Association of total cholesterol/ high-density lipoprotein cholesterol ratio with proximal coronary atherosclerosis detected by multislice computed tomography.
abstract: The authors assessed the association between an elevated total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio (> or = 4) and proximal coronary artery disease (CAD), as observed on multislice computed tomography. Coronary multislice computed tomographic angiography (96% on 40- or 64-slice) was performed in 295 individuals (39% women; mean age, 54 +/- 13 years) without documented CAD who were referred for coronary evaluation. Significant CAD was defined as > or = 50% stenosis in the left main, proximal left anterior descending, or > or = 2 epicardial vessels. Proximal plaque was defined as presence of any plaque in left main or proximal left anterior descending vessels. Individuals with an elevated TC/HDL-C ratio vs those without had a higher prevalence of proximal plaque (62% vs 48%, P = .04) and significant CAD (19% vs 9%, P = .009). On multivariate logistic regression analysis, only age, sex, and TC/HDL-C ratio > or = 4 were associated with significant CAD and proximal plaque.
authors.affiliation: Cardiovascular Imaging Laboratory, Heart and Vascular Institute, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Deepu
authors.initials: D
authors.lastname: Nair
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Carrigan
authors.forename: Ronan J
authors.initials: RJ
authors.lastname: Curtin
authors.forename: Zoran B
authors.initials: ZB
authors.lastname: Popovic
authors.forename: Stacie
authors.initials: S
authors.lastname: Kuzmiak
authors.forename: Paul
authors.initials: P
authors.lastname: Schoenhagen
authors.forename: Scott D
authors.initials: SD
authors.lastname: Flamm
authors.forename: Milind Y
authors.initials: MY
authors.lastname: Desai
mesh_terms: D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009820:Ohio / Q000453:epidemiology; D015995:Prevalence; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D008076:Cholesterol, HDL; D002784:Cholesterol