title: Physical activity, high-density lipoprotein cholesterol subfractions and lecithin:cholesterol acyltransferase in dialysis patients.
abstract: OBJECTIVE
  Although a low level of high-density lipoprotein cholesterol (HDL-C) is an independent risk factor for atherosclerotic heart disease, the mechanism of HDL-C abnormality in hemodialysis (HD) as well as peritoneal dialysis (PD) patients is not fully understood. The purpose of this study was to investigate the relationship of physical activity with HDL-C subfractions and lecithin:cholesterol acyltransferase activity in HD and PD patients.
  
  
  METHODS
  Thirty-five HD and 26 PD patients were studied. Physical activity was estimated as the average number of steps taken per day over 7 days (steps/day).
  
  
  RESULTS
  When possible confounding factors were included in the stepwise multiple regression analyses, in HD patients, steps/day was significantly positively related to HDL(2)-C and apolipoprotein (Apo) A-I, while it was significantly positively related to HDL(3)-C in PD patients. When subjects were subdivided into 3 groups according to steps/day, in HD patients, the highest category of steps/day had significantly higher HDL(2)-C and Apo A-I than the lowest category, while such results were not observed in PD patients.
  
  
  CONCLUSIONS
  These results suggest that the associations of physical activity with HDL-C subfractions and Apo A-I that are known in the general population are more pronounced in HD patients than PD patients.
authors.affiliation: Laboratory of Nutrition and Exercise Physiology, Nakamura Gakuen University Graduate School, 5-7-1 Befu, Jonan-ku, Fukuoka, Japan.
authors.forename: Reika
authors.initials: R
authors.lastname: Masuda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Imamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Mizuuchi
authors.forename: Keiko
authors.initials: K
authors.lastname: Miyahara
authors.forename: Harumitsu
authors.initials: H
authors.lastname: Kumagai
authors.forename: Hideki
authors.initials: H
authors.lastname: Hirakata
mesh_terms: D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy*; D054709:Lecithins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009043:Motor Activity; D006435:Renal Dialysis; D002785:Sterol O-Acyltransferase / Q000097:blood*
chemical_list: D054709:Lecithins; D008075:Lipoproteins, HDL; D002785:Sterol O-Acyltransferase