title: In Vitro activity of terbinafine combined with caspofungin and azoles against Pythium insidiosum.
abstract: In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.
authors.affiliation: Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Ayrton S
authors.initials: AS
authors.lastname: Cavalheiro
authors.forename: Grazieli
authors.initials: G
authors.lastname: Maboni
authors.forename: Maria I
authors.initials: MI
authors.lastname: de Azevedo
authors.forename: Juliana S
authors.initials: JS
authors.lastname: Argenta
authors.forename: Daniela I B
authors.initials: DI
authors.lastname: Pereira
authors.forename: Tatiana B
authors.initials: TB
authors.lastname: Spader
authors.forename: Sydney H
authors.initials: SH
authors.lastname: Alves
authors.forename: Janio M
authors.initials: JM
authors.lastname: Santurio
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000145:classification / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D001938:Brazil; D000077336:Caspofungin; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000494:pharmacology*; D006734:Horse Diseases / Q000382:microbiology; D006736:Horses; D007239:Infections / Q000382:microbiology; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests / Q000379:methods; D009281:Naphthalenes / Q000494:pharmacology*; D011775:Pythium / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D000077291:Terbinafine
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D000077336:Caspofungin; D000077291:Terbinafine