title: Bioactive nano-titania ceramics with biomechanical compatibility prepared by doping with piezoelectric BaTiO(3).
abstract: Piezoelectric BaTiO(3) was employed as a crystal growth inhibitor additive for the preparation of bioactive nano-titania ceramics in this study. It is found that the additive could significantly inhibit nano-titania ceramic crystal growth during the pressureless sintering process. This inhibitory ability has great effects on the mechanical properties and bioactivities of the nano-titania ceramics, making it possible to obtain bioactive nano-titania ceramics with mechanical properties analogous to human bone. In this study, the crystal grain sizes of the nano-titania ceramics ranged from 18 to 68nm and the particle sizes ranged from 187 to 580nm by changing the additive content from 1% to 20%. The elastic modulus of the nano-titania ceramics ranged from 6.2 to 10.6GPa, which is analogous to that of human bone, by adjusting the additive content. The piezoelectric properties of the additive also showed the enhancing effects on the bioactivity of the nano-titania ceramics, which made the osteoblasts proliferate faster on the nano-titania ceramics in cell culture experiments. It might be a potential way to prepare bioactive nano-titania ceramics with biomechanical compatibility by using BaTiO(3) as a crystal growth inhibitor.
authors.affiliation: Engineering Research Center in Biomaterials, Sichuan University, Chengdu, China.
authors.forename: Zhensheng
authors.initials: Z
authors.lastname: Li
authors.forename: Yang
authors.initials: Y
authors.lastname: Qu
authors.forename: Xingdong
authors.initials: X
authors.lastname: Zhang
authors.forename: Bangcheng
authors.initials: B
authors.lastname: Yang
mesh_terms: D000818:Animals; D017609:Barium Compounds / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry*; D018786:Bone Substitutes / Q000737:chemistry*; D002460:Cell Line; D049109:Cell Proliferation; D002516:Ceramics / Q000737:chemistry*; D019245:Compressive Strength; D003460:Crystallization / Q000379:methods; D055119:Elastic Modulus; D004563:Electrochemistry / Q000379:methods; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000502:physiology*; D051381:Rats; D014025:Titanium / Q000737:chemistry*
chemical_list: D017609:Barium Compounds; D001672:Biocompatible Materials; D018786:Bone Substitutes; C024547:barium titanate(IV); D014025:Titanium