title: Gold nanorod/Fe3O4 nanoparticle "nano-pearl-necklaces" for simultaneous targeting, dual-mode imaging, and photothermal ablation of cancer cells.
abstract: Gold and pearls: Multifunctional nanoparticles, each composed of a single, amine-modified gold nanorod, decorated with multiple "pearls" of Fe(3)O(4) nanoparticles capped with carboxy groups, are prepared. Their effectiveness in simultaneous targeting, dual-mode imaging, and photothermal ablation of breast cancer cells is demonstrated.
authors.affiliation: Birck Nanotechnology, Bindley Bioscience, and Purdue Cancer Center, Purdue University, 225 S. University Street, West Lafayette, IN 47906, USA.
authors.forename: Chungang
authors.initials: C
authors.lastname: Wang
authors.forename: Jiji
authors.initials: J
authors.lastname: Chen
authors.forename: Tom
authors.initials: T
authors.lastname: Talavage
authors.forename: Joseph
authors.initials: J
authors.lastname: Irudayaraj
mesh_terms: D000911:Antibodies, Monoclonal / Q000737:chemistry; D061067:Antibodies, Monoclonal, Humanized; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry*; D052203:Ferrosoferric Oxide / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D053768:Metal Nanoparticles / Q000032:analysis / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D008856:Microscopy, Fluorescence; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000628:therapy*; D010777:Photochemistry; D012542:Scattering, Radiation; D000068878:Trastuzumab
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D003287:Contrast Media; D006046:Gold; D000068878:Trastuzumab; D052203:Ferrosoferric Oxide