Novel small molecule activators of beta-catenin-mediated signaling pathway: structure-activity relationships of indirubins.
Based on the beta-catenin-drived Wnt activator of bromoindirubin-3'-oxime (BIO), indirubin analogs were evaluated for beta-catenin-mediated gene expression. A novel indirubin analog, indirubin-5-nitro-3'-oxime (INO), was considered a potential activator, and structure-activity studies were conducted with indirubins. These data suggest that INO might be a novel Wnt activator and has a potential of signaling regulator in beta-catenin-mediated signaling pathways.
Park
Eun-Jung
EJ
College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
Choi
Soo Jeong
SJ
Kim
Yong-Chul
YC
Lee
Sang Hyung
SH
Park
Seoung Woo
SW
Lee
Sang Kook
SK
D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013329:Structure-Activity Relationship; D051176:beta Catenin / Q000378:metabolism / Q000502:physiology*
D007211:Indoles; D051176:beta Catenin; C027185:indirubin