title: Comparison of hypoglycemic activity of trace elements absorbed in fermented mushroom of Coprinus comatus.
abstract: The effect of fermented mushroom of Coprinus comatus rich in trace elements, including vanadium, chromium, zinc, magnesium, copper, iron, and nickel, on glycemic metabolism was studied in this paper. Alloxan-induced hyperglycemic mice were used in the study. The blood glucose, glycohemoglobin, and glycogen synthesis of the mice were analyzed, respectively. At the same time, the gluconeogenesis of the normal mice was also determined. After the mice were administered (ig) with C. comatus rich in vanadium (CCRV), the blood glucose and the glycohemoglobin of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01), glycogen synthesis of alloxan-induced hyperglycemic mice elevated (p < 0.01), the gluconeogenesis of the normal mice was inhibited (p < 0.01), and the sugar tolerance of the normal mice was improved. However, the same result did not occur in other groups. Vanadium at lower doses in combination with C. comatus induced significant effect on glycemic metabolism in mice.
authors.affiliation: College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China.
authors.forename: Yingtao
authors.initials: Y
authors.lastname: Lv
authors.forename: Linna
authors.initials: L
authors.lastname: Han
authors.forename: Chao
authors.initials: C
authors.lastname: Yuan
authors.forename: Jianyou
authors.initials: J
authors.lastname: Guo
mesh_terms: D000496:Alloxan; D000818:Animals; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D002857:Chromium / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D003302:Coprinus / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D015536:Down-Regulation; D005260:Female; D005285:Fermentation; D005943:Gluconeogenesis; D006442:Glycated Hemoglobin / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D019216:Metals, Heavy / Q000494:pharmacology*; D051379:Mice; D008820:Mice, Obese; D012015:Reference Standards; D014639:Vanadium / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
chemical_list: D000496:Alloxan; D001786:Blood Glucose; D002857:Chromium; D003300:Copper; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007501:Iron; D019216:Metals, Heavy; D014639:Vanadium; D015032:Zinc