Sphingosine-1 phosphate: a new player in osteoimmunology.
Osteoclasts, the cells that degrade bone, differentiate from bone marrow-derived myeloid precursors. Recent work by Ishii et al. shows that sphingosine-1 phosphate in blood attracts osteoclast precursors into the bloodstream to keep them away from bone surfaces. These findings point to a novel mechanism to inhibit bone degradation and prevent bone loss.
Boyce
Brendan F
BF
Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, 601 Elmwood Avenue, Box 626, Rochester, NY 14642, USA. brendan_boyce@urmc.rochester.edu
D000818:Animals; D016723:Bone Remodeling / Q000276:immunology / Q000502:physiology*; D005260:Female; D006801:Humans; D008246:Lysophospholipids / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D010010:Osteoclasts / Q000276:immunology / Q000502:physiology; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000517:prevention & control; D049349:Receptors, Lysosphingolipid / Q000819:agonists / Q000502:physiology; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000276:immunology / Q000502:physiology; D000081025:Sphingosine-1-Phosphate Receptors
D008246:Lysophospholipids; D049349:Receptors, Lysosphingolipid; C477362:S1PR1 protein, human; D000081025:Sphingosine-1-Phosphate Receptors; C060506:sphingosine 1-phosphate; D013110:Sphingosine