title: Moving towards making social toxins mainstream in children's environmental health.
abstract: OBJECTIVE
  Although traditional disciplinary research theory and methods have focused separately on how social and physical environmental factors affect children's health, evolving research underscores important integrated effects.
  
  
  RESULTS
  This review outlines the specific reasons why social determinants should be considered mainstream in children's environmental health research with particular focus on interactive effects between social and physical hazards. These include sensitivity of overlapping physiological systems, via epigenesis, programming, and plasticity to social and physical environmental moderation that may impact health across the life span; ways in which social environmental vulnerabilities moderate the effects of physical environmental factors, providing specific examples related to respiratory health and neurodevelopment; overlapping exposure distribution profiles; and relevance to pediatric health disparities.
  
  
  CONCLUSIONS
  Because of the covariance across exposures, and evidence that social stress and other environmental toxins (e.g., pollutants, tobacco smoke) may influence common physiological pathways (e.g., oxidative stress, proinflammatory immune pathways, autonomic disruption), understanding the potential synergistic effects promises to more completely inform children's environmental health risk. Although this discussion focuses around the respiratory and neurological systems, these concepts extend more broadly to children's psychological and physical development.
authors.affiliation: The Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02067, USA. rerjw@channing.harvard.edu
authors.forename: Rosalind J
authors.initials: RJ
authors.lastname: Wright
mesh_terms: D000818:Animals; D015984:Causality; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000453:epidemiology*; D004782:Environmental Health; D054624:Health Status Disparities; D006801:Humans; D008954:Models, Biological; D012140:Respiratory Tract Diseases / Q000453:epidemiology*; D012931:Social Environment