title: PET/CT localisation of a scapular haemangiopericytoma with tumour-induced osteomalacia.
abstract: Oncogenic osteomalacia, or tumour-induced osteomalacia (TIO), is a rare paraneoplastic syndrome characterised by hypophosphataemia, phosphaturia, inappropriately low serum levels of 1,25-dihydroxyvitamin D for hypophosphataemia. TIO is caused by mesenchymal tumours that secrete phosphaturic substances, leading to increased renal wasting of phosphates. These tumours are very small in size and grow slowly. Localisation of these tumours has always been difficult with the available biochemical and imaging techniques. At times, despite all efforts, the tumour could not be localised. We report our experience with a 42-year-old woman with TIO where whole-body magnetic resonance imaging could not localise the tumour, a scapular haemangiopericytoma. PET/CT was helpful in the localisation of the tumour which, when surgically removed, resulted in the normalisation of biochemical parameters with clinical improvement.
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. rajeshkhadgawat@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Khadgawat
authors.forename: Y
authors.initials: Y
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Kansara
authors.forename: N
authors.initials: N
authors.lastname: Tandon
authors.forename: C
authors.initials: C
authors.lastname: Bal
authors.forename: A
authors.initials: A
authors.lastname: Seith
authors.forename: P
authors.initials: P
authors.lastname: Kotwal
mesh_terms: D000328:Adult; D001847:Bone Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging; D003287:Contrast Media / Q000494:pharmacology; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology; D006393:Hemangiopericytoma / Q000175:diagnosis* / Q000000981:diagnostic imaging*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010018:Osteomalacia / Q000175:diagnosis* / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000494:pharmacology; D012540:Scapula / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000378:metabolism
chemical_list: D003287:Contrast Media; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D