title: Adult patient with Epstein-Barr virus (EBV)-associated lymphoproliferative disorder: chronic active EBV infection or de novo extranodal natural killer (NK)/T-cell lymphoma, nasal type?
abstract: Chronic active Epstein-Barr virus (EBV) infection, which is considered to be a childhood disease, often develops into natural killer (NK) or T-cell lymphoma after recurrent infectious mononucleosis (IM)-like symptoms. We describe a 56-year-old woman who developed NK-cell lymphoma after 9 months of recurrent IM-like symptoms. The patient had an unusual anti-EBV antibody profile. Increased levels of EBV genome were detected in the liver and peripheral blood. Several chemotherapy regimens were ineffective, and the patient died of progression of lymphoma. Certain subtypes of NK-cell lymphoma showing a long-lasting prodrome related to chronic EBV infection may exist.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka.
authors.forename: Rie
authors.initials: R
authors.lastname: Ohtsuka
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Eriko
authors.initials: E
authors.lastname: Sada
authors.forename: Junichi
authors.initials: J
authors.lastname: Kiyasu
authors.forename: Akiyo
authors.initials: A
authors.lastname: Ashikari
authors.forename: Motoaki
authors.initials: M
authors.lastname: Shiratsuchi
authors.forename: Junji
authors.initials: J
authors.lastname: Nishimura
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002908:Chronic Disease; D003937:Diagnosis, Differential; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000175:diagnosis*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000821:virology; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis*; D013902:Radiography, Thoracic
chemical_list: D000914:Antibodies, Viral