Carbohydrate recognition by boronolectins, small molecules, and lectins.
Carbohydrates are known to mediate a large number of biological and pathological events. Small and macromolecules capable of carbohydrate recognition have great potentials as research tools, diagnostics, vectors for targeted delivery of therapeutic and imaging agents, and therapeutic agents. However, this potential is far from being realized. One key issue is the difficulty in the development of "binders" capable of specific recognition of carbohydrates of biological relevance. This review discusses systematically the general approaches that are available in developing carbohydrate sensors and "binders/receptors," and their applications. The focus is on discoveries during the last 5 years.
Jin
Shan
S
Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30302-4098, USA.
Cheng
Yunfeng
Y
Reid
Suazette
S
Li
Minyong
M
Wang
Binghe
B
D000818:Animals; D000951:Antigens, Neoplasm / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002417:Cattle; D045744:Cell Line, Tumor; D019040:E-Selectin / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D037102:Lectins / Q000737:chemistry*; D008024:Ligands; D051379:Mice; D011485:Protein Binding
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D001897:Boronic Acids; D002241:Carbohydrates; D019040:E-Selectin; D005456:Fluorescent Dyes; D037102:Lectins; D008024:Ligands