title: The evolving understanding of COPI vesicle formation.
abstract: The coat protein I (COPI) complex is considered to be one of the best-characterized coat complexes. Studies on how it functions in vesicle formation have provided seminal contributions to the general paradigm in vesicular transport that the ADP-ribosylation factor (ARF) small GTPases are key regulators of coat complexes. Here, we discuss emerging evidence that suggests the need to revise some long-held views on how COPI vesicle formation is achieved.
authors.affiliation: Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. vhsu@rics.bwh.harvard.edu
authors.forename: Victor W
authors.initials: VW
authors.lastname: Hsu
authors.forename: Stella Y
authors.initials: SY
authors.lastname: Lee
authors.forename: Jia-Shu
authors.initials: JS
authors.lastname: Yang
mesh_terms: D020727:ADP-Ribosylation Factors / Q000378:metabolism; D000818:Animals; D020755:Coat Protein Complex I / Q000378:metabolism / Q000502:physiology*; D018699:Coated Vesicles / Q000378:metabolism*; D006801:Humans
chemical_list: D020755:Coat Protein Complex I; D020727:ADP-Ribosylation Factors