Neutrophils in acute kidney injury: not neutral any more.
Awad and colleagues elucidate the spatiotemporal profile of neutrophil infiltration in the kidney following ischemia-reperfusion injury. Using elegant in vivo labeling techniques, they demonstrate increased neutrophil content in the kidney following ischemia-reperfusion, which is largely due to transmigration from the circulation into the interstitial compartment. The authors also provide mechanistic insights into this phenomenon and show that adenosine 2A receptor agonists reduce interstitial neutrophil infiltration and improve renal function.
Bolisetty
Subhashini
S
Division of Nephrology, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Agarwal
Anupam
A
D058908:Adenosine A2 Receptor Agonists; D006801:Humans; D007674:Kidney Diseases / Q000276:immunology / Q000473:pathology*; D020556:Neutrophil Infiltration / Q000276:immunology; D009504:Neutrophils / Q000502:physiology*; D043705:Receptor, Adenosine A2A / Q000502:physiology; D015427:Reperfusion Injury / Q000276:immunology*
D058908:Adenosine A2 Receptor Agonists; D043705:Receptor, Adenosine A2A