A novel composite membrane of chitosan-carboxymethyl cellulose polyelectrolyte complex membrane filled with nano-hydroxyapatite I. Preparation and properties.
A novel tri-component composite membranes of chitosan/carboxymethyl cellulose (CS/CMC) polyelectrolyte complex membranes filled with different weight ratios of nano-hydroxyapatite (n-HA)(0, 20, 40 and 60 wt%), namely, n-HA/CS/CMC composite membrane, were prepared by self-assembly of static electricity. The structure and the properties of the composite membranes were investigated by Fourier transformed infrared spectroscopy(IR), X-ray diffraction(XRD), Scanning electron microscopy(SEM), mechanical performance measurement, swelling behavior test, and soaking behavior study in phosphate buffered saline (PBS) and simulate body fluid (SBF). The results showed that the n-HA/CS/CMC composite membrane was formed though superficial static electricity interaction among n-HA, CS and CMC. For the n-HA/CS/CMC composite membrane, the microstructure compatibility, mechanical property, swelling behavior, the degradation and bioactivity in vitro of the composite membrane were improved by the addition of n-HA, compared with CS/CMC polyelectrolyte complex membrane. Moreover, the n-HA/CS/CMC composite membrane with 40 wt% n-HA had the most highest mechanical property, which suggested that the novel n-HA/CS/CMC composite membrane with 40 wt% n-HA was more suitable to be used as guided bone tissue regeneration membrane than CS/CMC polyelectrolyte complex membrane.
Liuyun
Jiang
J
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, China. jlytxg@163.com
Yubao
Li
L
Chengdong
Xiong
X
D020341:Absorbable Implants; D001861:Bone Regeneration / Q000502:physiology*; D002266:Carboxymethylcellulose Sodium / Q000138:chemical synthesis* / Q000737:chemistry; D048271:Chitosan / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D004573:Electrolytes / Q000138:chemical synthesis / Q000737:chemistry; D048091:Guided Tissue Regeneration / Q000295:instrumentation / Q000379:methods*; D008422:Materials Testing; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D049329:Nanostructures / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D054457:Tissue Scaffolds / Q000737:chemistry; D014961:X-Ray Diffraction
D004573:Electrolytes; D008567:Membranes, Artificial; C514968:carboxymethyl-chitosan; D048271:Chitosan; D017886:Durapatite; D002266:Carboxymethylcellulose Sodium