title: Sublethal cyfluthrin toxicity to carp (Cyprinus carpio L.) fingerlings: biochemical, hematological, histopathological alterations.
abstract: This study measures a whole series of biological endpoints, and histopathological and behavioral changes of carp (Cyprinus carpio L.) fingerlings in order to investigate the adverse effects of a sublethal concentration of 10 microg/L cyfluthrin for 48h and one week using the semi-static test system. The most significantly altered findings of this study was that total antioxidant status levels decreased in 48h, chloride levels decreased in one week, and sodium and phosphorous levels increased in the 48h-exposed group. Plasma cortisol increased in both the 48h-exposed and the one-week-exposed groups. The unique tissue was the brain that had an increased level of malondialdehyde after one week of exposure. Such biomarkers may be used in assessing adverse/toxic effects of pesticides as environmental stressors. Potential oxidative-stress-inducing effect of synthetic pyrethroid cyfluthrin, as lipid peroxidation, in addition to its sodium channel blocking, is reported for the first time as an additional mechanism of action.
authors.affiliation: Department of Medical Biochemistry, Faculty of Medicine, Gazi University, Ankara, Turkey. asepici@yahoo.com
authors.forename: Aylin
authors.initials: A
authors.lastname: Sepici-Dinçel
authors.forename: A
authors.initials: A
authors.lastname: Cağlan Karasu Benli
authors.forename: Mahmut
authors.initials: M
authors.lastname: Selvi
authors.forename: Rabia
authors.initials: R
authors.lastname: Sarikaya
authors.forename: Duygu
authors.initials: D
authors.lastname: Sahin
authors.forename: I
authors.initials: I
authors.lastname: Ayhan Ozkul
authors.forename: Figen
authors.initials: F
authors.lastname: Erkoç
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D002347:Carps / Q000097:blood / Q000254:growth & development / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods; D005880:Gills / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007306:Insecticides / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D009570:Nitriles / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects; D011722:Pyrethrins / Q000633:toxicity*; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007306:Insecticides; D009570:Nitriles; D011722:Pyrethrins; D014874:Water Pollutants, Chemical; C052570:cyfluthrin