title: Vitamin D status and falls, frailty, and fractures among postmenopausal Japanese women living in Hawaii.
abstract: Vitamin D status and its relationship to physical performance, falls, and fractures in 495 postmenopausal women of Japanese ancestry in Hawaii were investigated. The mean 25-hydroxyvitamin D (25-OHD) was 31.94 ng/mL. No significant association of 25-OHD was demonstrated with most outcomes, possibly due to higher 25-OHD levels in this population.
  
  
  BACKGROUND
  In this study, we investigated vitamin D status and its relationship to physical performance, muscle strength, falls, and fractures in postmenopausal Japanese females living in Hawaii.
  
  
  METHODS
  Of 510 community-dwelling women who participated in the eighth examination of the Hawaii Osteoporosis Study, 495 were included in these analyses. Multivariate regression models were used to evaluate the relationship of 25-OHD (D(3) and total) to eight performance-based measurements, 12 activities of daily living (ADLs), and muscle strength (grip, triceps, and quadriceps). Logistic regression analyses were performed to evaluate the relationship of 25-OHD to falls, vertebral fractures, and non-vertebral fractures.
  
  
  RESULTS
  The mean total 25-OHD was 31.94 +/- 9.46 ng/mL; 44% of subjects had values <30 ng/mL, while none had values <10-12 ng/mL. There was little evidence of seasonal variation. Among performance-based measures, ADLs, and strength tests, only quadriceps strength was significantly associated with total 25-OHD (p = 0.0063) and 25-OHD(3) (p = 0.0001). No significant association of 25-OHD was found with vertebral or non-vertebral fractures, or incidence of one or more falls.
  
  
  CONCLUSIONS
  Lack of serum 25-OHD relationship with falls and fractures or most physical performance measures in this study may be related to the low prevalence of very low 25-OHD levels in this population.
authors.affiliation: University of Hawaii Internal Medicine Residency Program, Honolulu, HI, USA.
authors.forename: P
authors.initials: P
authors.lastname: Pramyothin
authors.forename: S
authors.initials: S
authors.lastname: Techasurungkul
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Shah
authors.forename: P D
authors.initials: PD
authors.lastname: Ross
authors.forename: R
authors.initials: R
authors.lastname: Puapong
authors.forename: R D
authors.initials: RD
authors.lastname: Wasnich
mesh_terms: D000058:Accidental Falls / Q000706:statistics & numerical data*; D000203:Activities of Daily Living; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data*; D015519:Bone Density; D002111:Calcaneus / Q000503:physiopathology; D005260:Female; D050723:Fractures, Bone / Q000097:blood / Q000208:ethnology* / Q000503:physiopathology; D016330:Frail Elderly; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000208:ethnology; D053580:Muscle Strength / Q000502:physiology; D017698:Postmenopause / Q000097:blood / Q000502:physiology; D012621:Seasons; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D