title: [Pharmacokinetics of PEG recombinant human interleukin-6 in rats].
abstract: OBJECTIVE
  To study the pharmacokinetics and tissue distribution of PEG-rhIL-6 in rats after a single dose administration.
  
  
  METHODS
  Pharmacokinetics and distribution of PEG-rhIL-6 in rats were studied by 125I isotope tracing method. Pharmacokinetic analysis was performed using 3P97 computer software.
  
  
  RESULTS
  PEG-rhIL-6 declined in one-compartment model with half-lives of 10.44-11.37 h for t1/2 Ka, 19.77-21.53 h for t1/2 Ke and 20.51-21.96 h for T(pcak), respectively. PEG-rhIL-6 was mainly distributed in blood and excreted via urine.
  
  
  CONCLUSIONS
  The half-lives of PEG-rhIL-6 are prolonged after being modified by PEG.
authors.affiliation: Laboratory Animal Center, Sichuan University, Chengdu 610041, China.
authors.forename: Xue-Ling
authors.initials: XL
authors.lastname: He
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Yin
authors.forename: Xue-Me
authors.initials: XM
authors.lastname: Zhang
mesh_terms: D000818:Animals; D005260:Female; D006207:Half-Life; D006801:Humans; D007279:Injections, Subcutaneous; D015850:Interleukin-6 / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D011994:Recombinant Proteins; D011092:Polyethylene Glycols