A study of the quantity of some stable and labile coagulation factors in fresh-frozen plasma produced from whole blood stored for 24 hours in Iran.
BACKGROUND
The aim of this study was to assess whether the quantities of some coagulation factors in fresh-frozen plasma (FFP) produced from whole blood stored at 4 degrees C for 24 h are adequate for their intended purpose.


METHODS
The amounts of some coagulation factors (fibrinogen, FV, FVII, FVIII, FX and FXI) in FFP separated from whole blood after storage at 4 degrees C for 24 h were compared with the amounts of the corresponding coagulation factors in FFP separated from whole blood within 8 h of donation.


RESULTS
In 98% of the FFP units prepared after 24 h of storage, the levels of fibrinogen, FV, FVII, FX and FXI were greater than 0.5 IU/mL. The concentration of FVIII in the 24 h plasma units was 82% of that found in the FFP units prepared within 8 h of blood collection. In FFP, FVIII, FVII and FX were reduced by 38%, 8% and 3%, respectively, but FV, FXI and fibrinogen were not reduced.


CONCLUSIONS
These data suggest that there is good retention of coagulation factor activity in plasma produced from whole blood stored at 4 masculineC for 24 h and that such plasma would be an acceptable product for most patients requiring FFP.
Naghadeh
Hossin Timori
HT
Research Center, Iranian Blood Transfusion Organization, Tehran, Iran.
Roudkenar
Mehryar Habibi
MH
D001779:Blood Coagulation Factors / Q000737:chemistry / Q000378:metabolism*; D001793:Blood Preservation; D003080:Cold Temperature; D006801:Humans; D007492:Iran; D010949:Plasma / Q000737:chemistry / Q000378:metabolism*; D013997:Time Factors
D001779:Blood Coagulation Factors