title: Hypoglycaemic and antioxidant activities of Ficus racemosa Linn. fruits.
abstract: The effects of Ficus racemosa Linn. fruit extract and fraction on fasting serum glucose levels of normal, type 1 and type 2 diabetic model rats are presented. The aqueous 80% EtOH extract and its water soluble fraction of F. racemosa fruit did not show any serum glucose lowering effect on non-diabetic and type 2 diabetic rats at the fasting condition, whereas the extract showed significant hypoglycaemic effect on the type 1 diabetic model rats. Both the extract and fraction were consistently active in both non-diabetic and types 1 and 2 diabetic model rats when fed simultaneously with glucose load. On the contrary, they were ineffective in lowering blood glucose levels when fed 30 min prior to glucose load. The 1-BuOH soluble part of the ethanol extract exhibited significant antioxidant activity in DPPH free radical scavenging assay. 3-O-(E)-Caffeoyl quinate (1) was isolated for the first time from this plant, which also showed significant antioxidant activity.
authors.affiliation: Bangladesh Council of Scientific and Industrial Research, Dhaka, Bangladesh. ismet0103@yahoo.com
authors.forename: Ismet Ara
authors.initials: IA
authors.lastname: Jahan
authors.forename: Nilufar
authors.initials: N
authors.lastname: Nahar
authors.forename: M
authors.initials: M
authors.lastname: Mosihuzzaman
authors.forename: Begum
authors.initials: B
authors.lastname: Rokeya
authors.forename: Liaquat
authors.initials: L
authors.lastname: Ali
authors.forename: A K
authors.initials: AK
authors.lastname: Azad Khan
authors.forename: Talat
authors.initials: T
authors.lastname: Makhmur
authors.forename: M
authors.initials: M
authors.lastname: Iqbal Choudhary
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D004195:Disease Models, Animal; D030681:Ficus / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D020318:Rats, Long-Evans
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts