title: Comparison of visual evoked-related potentials in healthy young adults of different catechol-O-methyltransferase genotypes in a continuous 3-back task.
abstract: We further support the notion that the catechol-O-methyltransferase (COMT) polymorphism may play a role in cognitive function. A continuous visual 3-back numerical working memory task was performed for an hour among 21 patients with different COMT genotypes. P300 visual event-related potentials evoked from the 3-back task were first utilized to observe the relationship between this COMT polymorphism and cortical physiology. The results showed that Val/Met heterozygous individuals show poorer performance, lower P300 amplitude, and higher P300 latency than those bearing the Val/Val homozygote on the task. This visual 3-back paradigm is a promising tool to examine continuous working memory capacity. The role of the COMT gene in dopamine catabolism makes for the influence of COMT polymorphism on P300 endophenotypes.
authors.affiliation: Institute of Biomedical Engineering, West China Medical Center, SichuanUniversity, Chengdu, China.
authors.forename: Chunlin
authors.initials: C
authors.lastname: Yue
authors.forename: Tiejun
authors.initials: T
authors.lastname: Wu
authors.forename: Weiming
authors.initials: W
authors.lastname: Deng
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Wang
authors.forename: Xuechuan
authors.initials: X
authors.lastname: Sun
mesh_terms: D000704:Analysis of Variance; D001921:Brain / Q000502:physiology*; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D004569:Electroencephalography; D005006:Ethnicity / Q000235:genetics; D018913:Event-Related Potentials, P300; D005074:Evoked Potentials, Visual; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D011110:Polymorphism, Genetic; D055815:Young Adult
chemical_list: D002394:Catechol O-Methyltransferase