title: Towards quorum-quenching catalytic antibodies.
abstract: The development of a novel method to attenuate bacterial virulence is reported, which is based upon the use of designed transition-state analogues to select human catalytic antibodies capable of degrading bacterial quorum-sensing molecules.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW. drspring@ch.cam.ac.uk.
authors.forename: Prashant B
authors.initials: PB
authors.lastname: Kapadnis
authors.forename: Evan
authors.initials: E
authors.lastname: Hall
authors.forename: Madeleine
authors.initials: M
authors.lastname: Ramstedt
authors.forename: Warren R J D
authors.initials: WR
authors.lastname: Galloway
authors.forename: Martin
authors.initials: M
authors.lastname: Welch
authors.forename: David R
authors.initials: DR
authors.lastname: Spring
mesh_terms: D054742:Acyl-Butyrolactones / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D017151:Antibodies, Catalytic / Q000378:metabolism*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D006868:Hydrolysis; D053038:Quorum Sensing; D013450:Sulfones / Q000737:chemistry*
chemical_list: D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D017151:Antibodies, Catalytic; D001426:Bacterial Proteins; D013450:Sulfones