Higher mitochondrial DNA copy number is associated with lower prevalence of microalbuminuria.
It has been suggested that mitochondrial dysfunction contributes to the initiation and development of atherosclerosis and cardiovascular disease. We examined the association between mitochondrial DNA (mtDNA) copy number and microalbuminuria in a cross-sectional community-based study. We measured peripheral blood mtDNA copy number in 694 adults without chronic kidney disease by a real-time PCR method. The overall prevalence of microalbuminuria (defined as an albumin creatinine ratio of 30 to 299 mg/g) was 4.5%. The prevalence of microalbuminuria decreased progressively from the lower to the upper quartiles of mtDNA copy number (6.9%, 5.7%, 2.9%, and 2.3% in quartiles 1, 2, 3, and 4, respectively, P=0.017 for trend). Multiple logistic regression models showed that the quartile of mtDNA copy number was independently associated with the prevalence of microalbuminuria (P=0.01 for trend). Compared with the lowest quartile, the highest quartile had an odds ratio of 0.22 for microalbuminuria (95% confidence interval, 0.05 to 0.87; P=0.03). Higher mtDNA copy number was associated with the lower prevalence of microalbuminuria in a community-based population.
Lee
Jung Eun
JE
Division of Nephrology, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea.
Park
Hansoo
H
Ju
Young Seok
YS
Kwak
Minhye
M
Kim
Jong Il
JI
Oh
Ha Young
HY
Seo
Jeong Sun
JS
D000328:Adult; D000419:Albuminuria / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D003430:Cross-Sectional Studies; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics*; D005260:Female; D018628:Gene Dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D055815:Young Adult
D004272:DNA, Mitochondrial