[Research concerning the characterization of Allium cepa based ointments].
Three topical formulae with Allium cepa L. extract 30% (w/w) were studied for the evaluation of their release profiles of flavonoids and for their potency on experimental wounds on mice. The rates of release were performed under occluded conditions using cellulose acetate membrane. Data obtained from the in vitro release show that the gel formula F1 is the most efficient in the membrane diffusion process. The rate of wound healing was assessed by the contracting ability and the period of epithelization. The most important effect in the contracting ability was noticed in the case of F2 formula.
Gafiţanu
Eliza
E
Universitatea de Medicină şi Farmacie "Gr.T. Popa" Iaşi, Facultatea de Farmacie, Disciplina de Tehnologie farmaceutică.
Tătărîngă
Gabriela
G
Ghiciuc
Cristina
C
Lupuşoru
Cătălina Elena
CE
Hăncianu
Monica
M
D000279:Administration, Cutaneous; D000818:Animals; D004195:Disease Models, Animal; D005419:Flavonoids / Q000494:pharmacology; D008297:Male; D051379:Mice; D009824:Ointments; D019697:Onions / Q000737:chemistry*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy*
D005419:Flavonoids; D009824:Ointments; D010936:Plant Extracts