Multicentric infantile myofibromatosis: a rare disorder of the calvarium.
BACKGROUND
Infantile myofibromatosis is a rare mesenchymal disorder that occurs predominantly in infancy and early childhood, in either solitary or multicentric form. It can affect soft tissue, muscle, skeleton, and occasionally, visceral organs. Infantile myofibromatosis without visceral involvement frequently undergoes spontaneous regression. Multicentric infantile myofibromatosis with involvement exclusively of the calvarium is extremely rare.


CONCLUSIONS
We report an 8-month-old girl who presented with multifocal calvarial lesions. The child underwent total excision of the temporal mass, and histopathological study gave a diagnosis of infantile myofibromatosis. Serial follow-up by neuroimaging was obtained at 3, 6, 12, and 24 months postoperatively. Three months after surgery, a new lesion in the midline of frontal bone was found, and there was partial regression of the occipital lesion. Complete regression of the untreated lesions was shown at 24 months. Illustrated by our patient and literature review, we emphasize the importance of recognition and proper intervention for this rare, nonmalignant disorder.
Zhou
Da-Biao
DB
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. dabiao.zhou@gmail.com
Zhao
Ji-Zong
JZ
Zhang
Dong
D
Huang
Xiao-Yuan
XY
D017677:Age Distribution; D017668:Age of Onset; D001847:Bone Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008578:Meninges / Q000000981:diagnostic imaging / Q000473:pathology; D018224:Myofibromatosis / Q000000981:diagnostic imaging / Q000473:pathology*; D009365:Neoplasm Regression, Spontaneous / Q000473:pathology* / Q000503:physiopathology; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D012886:Skull / Q000000981:diagnostic imaging / Q000254:growth & development / Q000473:pathology*; D013355:Subdural Space / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed