title: Osteoclastlike giant cell tumor of the salivary gland.
abstract: Giant cell tumor of the salivary gland is extremely rare, with only 15 cases published in the English literature. The tumor characteristically contains a mixture of multinucleated giant cells, resembling osteoclasts of bone, and neoplastic mononuclear cells. In about half of the reported cases, there is an associated carcinomatous component. We are reporting an additional case of giant cell tumor of the parotid gland that was initially misinterpreted as an extraosseous osteosarcoma in the biopsy specimen. The histologic and immunohistochemical findings as well as a review of the literature with discussion of the histogenesis of this unusual neoplasm are presented.
authors.affiliation: Department of Pathology, SUNY at Buffalo, Buffalo General Hospital, Buffalo, NY 14203, USA. xfang3@buffalo.edu
authors.forename: Xueping
authors.initials: X
authors.lastname: Fang
authors.forename: David G
authors.initials: DG
authors.lastname: Hicks
authors.forename: Wesley
authors.initials: W
authors.lastname: Hicks
authors.forename: Shaozeng
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005870:Giant Cell Tumors / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010010:Osteoclasts / Q000473:pathology*; D012516:Osteosarcoma / Q000473:pathology; D010307:Parotid Neoplasms / Q000378:metabolism / Q000473:pathology*