[The neuromuscular toxicity and clinical application of adriamycin].
Adriamycin (doxorubicin) is commonly used in the treatment of malignant tumours. In recent years,retrograde adriamycin sensory ganglionectomy has been used in treatment of trigeminal neuralgia and has obtained good therapeutic effect. The mechanism of action, particularly, of the toxic effects with different medication methods and choice of doses for muscle cells and nerve cells is still unclear. This article reviewed the mechanism and feature of the toxicity of adriamycin effects on these cells and its advance in experimental study. The damage of adriamycin was highly selective and self-limited. The different effects of adriamycin with different administration routes and doses is also described. Adriamycin shows great potentiality in treatment of trigeminal neuralgia, facial spasm and some other neuromuscular diseases.
Li
Chao
C
Department of Stomatology, Second Military Medical University, Shanghai 200003, China. lc1238@126.com
Jiang
Xiao-zhong
XZ
Zhao
Yun-fu
YF
D004317:Doxorubicin; D006801:Humans; D014277:Trigeminal Neuralgia
D004317:Doxorubicin