title: MIC6 associates with aldolase in host cell invasion by Toxoplasma gondii.
abstract: The transmembrane microneme protein MIC6 and its partner MIC1, MIC4 comprise an adhesive complex that play important roles in host cell attachment by the obligate intracellular parasite Toxoplasma gondii. Successful penetration of host cells by T. gondii depends on coordinated interactions between MICs complex and the parasite's cytoskeleton. We have identified that the carboxy-terminal cytoplasmic domain (C domain) of MIC6 interacts with aldolase and the parasite cytoskeleton. Our finding uncovers new features regarding MIC6-aldolase interactions in host cell invasion by T. gondii.
authors.affiliation: Department of Parasitology, Zhongshan School of Medicine, SunYat-sen University, Guangzhou, 510080, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Zheng
authors.forename: Ai
authors.initials: A
authors.lastname: He
authors.forename: Ming
authors.initials: M
authors.lastname: Gan
authors.forename: Zhouya
authors.initials: Z
authors.lastname: Li
authors.forename: Hualiang
authors.initials: H
authors.lastname: He
authors.forename: Ximei
authors.initials: X
authors.lastname: Zhan
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D006801:Humans; D047468:Immunoprecipitation; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D025941:Protein Interaction Mapping; D015800:Protozoan Proteins / Q000378:metabolism*; D014122:Toxoplasma / Q000472:pathogenicity*
chemical_list: D015815:Cell Adhesion Molecules; C512738:MIC6 protein, Toxoplasma gondii; D015800:Protozoan Proteins; D005634:Fructose-Bisphosphate Aldolase