title: Interactions between chronic stress and chronic consumption of caffeine on the enzymatic antioxidant system.
abstract: We studied the effect of chronic caffeine on parameters related to oxidative stress in different brain regions of stressed and non-stressed rats. Wistar rats were divided into three groups: control (receiving water), caffeine 0.3 g/L and caffeine 1.0 g/L (in the drinking water). These groups were subdivided into non-stressed and stressed (repeated restraint stress during 40 days). Lipid peroxide levels and the total radical-trapping potential were assessed, as well as antioxidant enzyme activities superoxide dismutase, gluthatione peroxidase, and catalase in hippocampus, striatum and cerebral cortex. Results showed interactions between stress and caffeine, especially in the cerebral cortex, since caffeine increased the activity of some antioxidant enzymes, but not in stressed animals. We concluded that chronic administration of caffeine led, in some cases, to increased activity of antioxidant enzymes. However, these effects were not observed in the stressed animals.
authors.affiliation: Departamento de Bioquímica, Instituto de Ciências Básica da Saúde, ICBS, UFRGS, Ramiro Barcellos, Porto Alegre, RS, Brazil. cristienoschang@hotmail.com
authors.forename: Cristie Grazziotin
authors.initials: CG
authors.lastname: Noschang
authors.forename: Rachel
authors.initials: R
authors.lastname: Krolow
authors.forename: Leticia Ferreira
authors.initials: LF
authors.lastname: Pettenuzzo
authors.forename: Mônica Colpini
authors.initials: MC
authors.lastname: Avila
authors.forename: Andrelisa
authors.initials: A
authors.lastname: Fachin
authors.forename: Danusa
authors.initials: D
authors.lastname: Arcego
authors.forename: Eduardo
authors.initials: E
authors.lastname: von Pozzer Toigo
authors.forename: Leonardo Machado
authors.initials: LM
authors.lastname: Crema
authors.forename: Luísa Amália
authors.initials: LA
authors.lastname: Diehl
authors.forename: Deusa
authors.initials: D
authors.lastname: Vendite
authors.forename: Carla
authors.initials: C
authors.lastname: Dalmaz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002110:Caffeine / Q000494:pharmacology*; D002374:Catalase / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D002110:Caffeine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase