Hyperimmunoglobulin E syndrome (Job's syndrome).
Hyperimmunoglobulin E (Hyper IgE) syndrome, also described as Job's syndrome, is a rare primary immunodeficiency disease characterized by recurrent skin and respiratory tract infections, chronic eczematous dermatitis, skeletal abnormalities associated with markedly elevated serum IgE levels. Variable impaired T cell function is described in this disease, but no direct association between IgE levels or clinical manifestations with these abnormalities does exist. We report a case of a patient with recurrent staphylococcal cold abscesses, eczematous dermatitis and high serum IgE levels in which the treatment with Cyclosporine A seems to have a favorable effect.
Tămaş
Maria-Magdalena
MM
Department of Rheumatology, Iuliu Haţieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. mm_tamas@yahoo.com
Baican
Corina
C
Rednic
Simona
S
D000328:Adult; D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007589:Job Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008297:Male
D007166:Immunosuppressive Agents; D016572:Cyclosporine