title: Novel small molecule activators of beta-catenin-mediated signaling pathway: structure-activity relationships of indirubins.
abstract: Based on the beta-catenin-drived Wnt activator of bromoindirubin-3'-oxime (BIO), indirubin analogs were evaluated for beta-catenin-mediated gene expression. A novel indirubin analog, indirubin-5-nitro-3'-oxime (INO), was considered a potential activator, and structure-activity studies were conducted with indirubins. These data suggest that INO might be a novel Wnt activator and has a potential of signaling regulator in beta-catenin-mediated signaling pathways.
authors.affiliation: College of Pharmacy, Ewha Womans University, Seoul, Republic of Korea.
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Park
authors.forename: Soo Jeong
authors.initials: SJ
authors.lastname: Choi
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Kim
authors.forename: Sang Hyung
authors.initials: SH
authors.lastname: Lee
authors.forename: Seoung Woo
authors.initials: SW
authors.lastname: Park
authors.forename: Sang Kook
authors.initials: SK
authors.lastname: Lee
mesh_terms: D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013329:Structure-Activity Relationship; D051176:beta Catenin / Q000378:metabolism / Q000502:physiology*
chemical_list: D007211:Indoles; D051176:beta Catenin; C027185:indirubin