title: [Alcoholic ketoacidosis].
abstract: Alcoholic ketoacidosis is an acute metabolic acidosis that typically occurs in people who chronically abuse alcohol and have a recent history of binge drinking, little or no food intake and persistent vomiting. Alcoholic ketoacidosis is a result of starvation with glycogen depletion and counter-regulatory hormone production, a raised nicotinamide adenine dinucleotide (NADH) to nicotinamide adenine dinucleotide (NAD+) ratio related to the metabolism of ethanol, and volume depletion resulting in ketogenesis. Alcoholic ketoacidosis is characterized by elevated serum ketone levels and a high anion gap. Once the diagnosis of alcoholic ketoacidosis is made, the mainstay of treatment is hydration with 5% dextrose in normal saline. With timely and aggressive intervention, the prognosis for a patient with alcoholic ketoacidosis is good.
authors.affiliation: Universitatea de Medicină si Farmacie Gr T Popa Iaşi, Facultatea de Medicină, Centrul Clinic de Diabet, Nutriţie si Boli Metabolice.
authors.forename: B
authors.initials: B
authors.lastname: Mihai
authors.forename: Cristina
authors.initials: C
authors.lastname: Lăcătuşu
authors.forename: Mariana
authors.initials: M
authors.lastname: Graur
mesh_terms: D000435:Alcoholic Intoxication / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D003937:Diagnosis, Differential; D005440:Fluid Therapy / Q000379:methods; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D007662:Ketosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011379:Prognosis; D013549:Sweetening Agents / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D013549:Sweetening Agents; D005947:Glucose