title: Cytoskeleton rearrangements during Listeria infection: clathrin and septins as new players in the game.
abstract: The study of an infection process can reveal how microbes exploit the host, and can illuminate unknown host cellular functions. Invasive pathogens have evolved efficient strategies to promote their internalization within normally non-phagocytic host cells. The so-called "zippering" bacteria present to host cell receptors molecules that mimic endogenous ligands, thereby inducing specific intracellular signaling cascades ultimately resulting in actin polymerization and uptake. Here we review how the bacterial pathogen Listeria monocytogenes enters into cells, and present a series of studies revealing that in addition to actin rearrangements this bacterium exploits the clathrin-mediated endocytosis machinery together with septins, a novel cytoskeleton element. The challenge is now to decipher how all of these components orchestrate themselves to permit entry into normally non-phagocytic cells.
authors.affiliation: Institut Pasteur, Département de Biologie Cellulaire et Infection, Unité des Interactions Bactéries-Cellules, Paris, F-75015 France.
authors.forename: Serge
authors.initials: S
authors.lastname: Mostowy
authors.forename: Pascale
authors.initials: P
authors.lastname: Cossart
mesh_terms: D000199:Actins / Q000378:metabolism*; D001426:Bacterial Proteins / Q000502:physiology; D015820:Cadherins / Q000502:physiology; D002966:Clathrin / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism* / Q000502:physiology; D003599:Cytoskeleton / Q000378:metabolism*; D004705:Endocytosis; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D008089:Listeria monocytogenes / Q000502:physiology; D008088:Listeriosis / Q000503:physiopathology*; D008565:Membrane Proteins / Q000502:physiology; D019859:Proto-Oncogene Proteins c-met / Q000378:metabolism; D058112:Septins
chemical_list: D000199:Actins; D001426:Bacterial Proteins; D015820:Cadherins; D002966:Clathrin; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; C095768:inlB protein, Listeria monocytogenes; D019859:Proto-Oncogene Proteins c-met; D019204:GTP-Binding Proteins; C474315:SEPTIN9 protein, human; D058112:Septins