title: Theoretic basis and technical implementations of CT perfusion in acute ischemic stroke, part 2: technical implementations.
abstract: CT perfusion (CTP) is a functional imaging technique that provides important information about capillary-level hemodynamics of the brain parenchyma and is a natural complement to the strengths of unenhanced CT and CT angiography in the evaluation of acute stroke, vasospasm, and other neurovascular disorders. CTP is critical in determining the extent of irreversibly infarcted brain tissue (infarct "core") and the severely ischemic but potentially salvageable tissue ("penumbra"). This is achieved by generating parametric maps of cerebral blood flow, cerebral blood volume, and mean transit time.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA. akonstas@partners.org
authors.forename: A A
authors.initials: AA
authors.lastname: Konstas
authors.forename: G V
authors.initials: GV
authors.lastname: Goldmakher
authors.forename: T-Y
authors.initials: TY
authors.lastname: Lee
authors.forename: M H
authors.initials: MH
authors.lastname: Lev
mesh_terms: D000465:Algorithms; D002545:Brain Ischemia / Q000150:complications* / Q000000981:diagnostic imaging*; D002533:Cerebral Angiography / Q000379:methods; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D020521:Stroke / Q000000981:diagnostic imaging* / Q000209:etiology*; D014057:Tomography, X-Ray Computed / Q000379:methods*