title: Effects of beraprost sodium, an oral prostaglandin i2 analog, on hemostatic factors and inflammation in chronic peritoneal dialysis patients.
abstract: Beraprost sodium, an orally active prostaglandin I2 analog with vasodilatory, cytoprotective, antiplatelet, antithrombotic, and anti-inflammatory effects, 120 microg daily for 8 weeks, decreased plasma D-dimer, a marker of intravascular coagulation, and von Willebrand factor, a marker for endothelial injury, in 100 chronic peritoneal dialysis patients. Total cholesterol, triglycerides, high-density lipoprotein, apolipoprotein A1, apolipoprotein B, albumin, prealbumin, fibrinogen, troponin-T, and high-sensitivity C-reactive protein levels were not changed. Three patients complained of headache and 1 patient experienced facial flushing; however, no serious adverse effects were observed. These results suggest that beraprost sodium is effective in partially reversing the thrombogenic coagulation profile and endothelial injury in chronic peritoneal dialysis patients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Kim
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Kim
authors.forename: Jang Han
authors.initials: JH
authors.lastname: Lee
authors.forename: Jai Won
authors.initials: JW
authors.lastname: Chang
authors.forename: Jung Sik
authors.initials: JS
authors.lastname: Park
authors.forename: Soon Bae
authors.initials: SB
authors.lastname: Kim
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
chemical_list: D000209:Acute-Phase Proteins; D001779:Blood Coagulation Factors; D018836:Inflammation Mediators; D008074:Lipoproteins; D010975:Platelet Aggregation Inhibitors; C048081:beraprost; D011464:Epoprostenol