title: Association between the use of non-antiarrhythmic drugs and postoperative atrial fibrillation.
abstract: OBJECTIVE
  To evaluate the association between statins, N-acetylcysteine (NAC) and angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) and postoperative atrial fibrillation (AF).
  
  
  METHODS
  A total of 590 patients undergoing coronary artery bypass and/or valve surgery were studied. An AF episode lasting >5 min during hospitalization was accepted as endpoint.
  
  
  RESULTS
  AF rate was 18% (n=106). Multivariable positive predictors of AF included age ≥ 65, left atrial diameter ≥ 45 mm, cross clamp time; negative predictors included use of left internal mammarian artery, NAC, and ACEIs or ARBs.
  
  
  CONCLUSIONS
  ACEIs or ARBs and NAC is associated with low incidence of postoperative AF, however, this association was not found with statin or combined use these agents.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozaydin
authors.forename: Yasin
authors.initials: Y
authors.lastname: Turker
authors.forename: Oktay
authors.initials: O
authors.lastname: Peker
authors.forename: Dogan
authors.initials: D
authors.lastname: Erdogan
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.forename: Abdullah
authors.initials: A
authors.lastname: Dogan
authors.forename: Erdogan
authors.initials: E
authors.lastname: Ibrisim
mesh_terms: D000111:Acetylcysteine / Q000627:therapeutic use; D057911:Angiotensin Receptor Antagonists / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000188:drug therapy* / Q000209:etiology*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000111:Acetylcysteine