title: Chiral Brønsted acid-catalyzed enantioselective alpha-hydroxylation of beta-dicarbonyl compounds.
abstract: A novel, facile, and highly enantioselective Brønsted acid-catalyzed alpha-hydroxylation of beta-dicarbonyl compounds with up to 99:1 er using nitroso compounds as the oxygen source has been developed. The results disclosed herein considerably extend the substrate scope for the alpha-aminoxylation, allowing expeditious, straightforward, and efficient access to valuable alpha-hydroxy-beta-dicarbonyl compounds with the highest levels of enantiocontrol.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Di
authors.initials: D
authors.lastname: Zhu
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Lu
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zeng
authors.forename: Bin
authors.initials: B
authors.lastname: Tan
authors.forename: Zhenjiang
authors.initials: Z
authors.lastname: Xu
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong
mesh_terms: D000143:Acids / Q000737:chemistry*; D002384:Catalysis; D006900:Hydroxylation; D007659:Ketones / Q000138:chemical synthesis / Q000737:chemistry*; D009603:Nitroso Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000143:Acids; D007659:Ketones; D009603:Nitroso Compounds