title: 5-(Pyrrolidin-2-yl)tetrazole-catalyzed aldol and mannich reactions: acceleration and lower catalyst loading in a continuous-flow reactor.
abstract: Continuous organocatalysis: Fast aldol and Mannich reactions require less catalyst when conducted in a microreactor. A proline tetrazole derivative (5-10 mol %) catalyzes asymmetric aldol reactions between various aromatic aldehydes and ketones in microreactor at 60 degrees C with reaction times ranging from 10 to 30 min.
authors.affiliation: Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zurich, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland.
authors.forename: Arjan
authors.initials: A
authors.lastname: Odedra
authors.forename: Peter H
authors.initials: PH
authors.lastname: Seeberger
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry; D011392:Proline / Q000138:chemical synthesis / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism; D013696:Temperature; D013777:Tetrazoles / Q000138:chemical synthesis / Q000737:chemistry*; D013997:Time Factors
chemical_list: C540256:5-(pyrrolidin-2-yl)tetrazole; D000447:Aldehydes; D007659:Ketones; D011759:Pyrrolidines; D013777:Tetrazoles; D011392:Proline