title: Solution structure of a locked nucleic acid modified quadruplex: introducing the V4 folding topology.
abstract: Sharp curves: The structure of a locked nucleic acid modified telomeric sequence from Oxytricha nova displays a remarkable folding topology, distinct from the native O. nova quadruplex. Each guanine stretch folds back in a V-shaped turn that puts the first and fourth guanines in the same tetrad, looping over a tetrad with a sharp turn in the DNA backbone, showing how subtle interplay between sequence and conformation defines the folding topology.
authors.affiliation: Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
authors.forename: Jakob T
authors.initials: JT
authors.lastname: Nielsen
authors.forename: Khalil
authors.initials: K
authors.lastname: Arar
authors.forename: Michael
authors.initials: M
authors.lastname: Petersen
mesh_terms: D020029:Base Pairing; D054856:G-Quadruplexes; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; C477371:locked nucleic acid