Matrix-free formation of gas-phase biomolecular ions by soft cluster-induced desorption.
All in a ball: Neutral molecular clusters consisting of a few thousand molecules can be seen as tiny snow balls; if they are thrown fast enough onto a surface, they are able to pick up biomolecules such as insulin from that surface. Since they break down and evaporate during and after the collision, bare biomolecular ions are available for mass spectrometry after such an energetic throw.
Gebhardt
Christoph R
CR
Max-Planck-Institut für Quantenoptik, Hans-Kopfermann-Strasse 1, 85748 Garching, Germany. christoph.gebhardt@bdal.de
Tomsic
Anna
A
Schröder
Hartmut
H
Dürr
Michael
M
Kompa
Karl L
KL
D000596:Amino Acids / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / Q000379:methods*; D013458:Sulfur Dioxide / Q000737:chemistry*
D000596:Amino Acids; D007477:Ions; D011506:Proteins; D013458:Sulfur Dioxide