Potential use of the hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus expressed in Rachiplusia nu larvae as an immunogen for chickens.
The hemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV) was obtained as a recombinant antigen in Rachiplusia nu larvae. When it was used as an immunogen in chickens, a solid immune response, including neutralizing antibodies, was detected, demonstrating the potential use of this simple and economic strategy in the design of recombinant anti-NDV vaccines.
Chimeno Zoth
Silvina
S
Instituto de Biotecnología, CICVyA, INTA, Castelar, Cc 25 B1712WAA, Buenos Aires, Argentina.
Gómez
Evangelina
E
Carballeda
Juan Manuel
JM
Taboga
Oscar
O
Carrillo
Elisa
E
Berinstein
Analía
A
D000818:Animals; D030801:Animals, Genetically Modified; D000914:Antibodies, Viral / Q000097:blood; D002645:Chickens; D015707:HN Protein / Q000276:immunology*; D007313:Insecta / Q000235:genetics / Q000378:metabolism; D007814:Larva / Q000235:genetics / Q000378:metabolism; D009500:Neutralization Tests; D009521:Newcastle Disease / Q000517:prevention & control*; D009522:Newcastle disease virus / Q000276:immunology*; D011201:Poultry Diseases / Q000517:prevention & control*; D014614:Vaccines, Synthetic / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
D000914:Antibodies, Viral; D015707:HN Protein; D014614:Vaccines, Synthetic; D014765:Viral Vaccines