title: Functional polymorphisms of matrix metallopeptidase-9 and risk of coronary artery disease in a Chinese population.
abstract: Matrix metallopeptidase-9 (MMP-9) plays a pivotal role in vascular remodeling and development of atherosclerotic lesion. The potentially functional MMP-9 polymorphisms may contribute to the susceptibility of coronary artery disease (CAD). A case-control study composed of 762 CAD cases and 555 CAD-free controls was conducted in a Chinese population to investigate the association between the MMP-9 -1562 C>T, R279Q, P574R and R668Q polymorphisms and CAD risk. It was found that the variant genotypes of R279Q, P574R and R668Q were associated with a non-significant decreased risk of CAD when compared with their wild-type genotypes, respectively, Furthermore, compared with those without any variant genotypes for these four nonsynonymouse loci, individuals carrying all four variant genotypes (-1562 CT/TT, 279 RQ/QQ, 574 PR/RR and 668 RQ/QQ) had a 51% decreased risk of CAD (adjusted OR = 0.49; 95% CI = 0.26-0.95, P = 0.033). Although no significant main effects were observed for MMP-9 -1562 C>T locus on CAD risk, variant genotypes of -1562 C>T were associated with a 2.53 increased risk of CAD in subjects with diabetes mellitus (DM) (95% CI = 1.18-5.45, P = 0.018). In CAD cases, variant genotypes of -1562 C>T were associated with a significantly increased risk of MI (adjusted OR, 1.48, 95% CI, 1.01-2.20, P = 0.048). These findings suggest that MMP-9 R279Q, P574R and R668Q may have combined effect in the occurrence of CAD and -1562 CT/TT genotypes may contribute to CAD in diabetics and MI in CAD patients.
authors.affiliation: Department of Cardiology, ZhongDa Hospital, Southeast University, Nanjing, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Zhi
authors.forename: Hua
authors.initials: H
authors.lastname: Wang
authors.forename: Liqun
authors.initials: L
authors.lastname: Ren
authors.forename: Zhiyang
authors.initials: Z
authors.lastname: Shi
authors.forename: Haiyan
authors.initials: H
authors.lastname: Peng
authors.forename: Lunbiao
authors.initials: L
authors.lastname: Cui
authors.forename: Genshan
authors.initials: G
authors.lastname: Ma
authors.forename: Xingzhou
authors.initials: X
authors.lastname: Ye
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.forename: Chengxing
authors.initials: C
authors.lastname: Shen
authors.forename: Xiangjun
authors.initials: X
authors.lastname: Zhai
authors.forename: Chenyu
authors.initials: C
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Zen
authors.forename: Naifeng
authors.initials: N
authors.lastname: Liu
mesh_terms: D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003324:Coronary Artery Disease / Q000150:complications / Q000201:enzymology* / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis; D012907:Smoking / Q000235:genetics
chemical_list: D020780:Matrix Metalloproteinase 9