title: Effect of renal function loss on NT-proBNP level variations.
abstract: OBJECTIVE
  NT-proBNP level is used for the detection of acute CHF and as a predictor of survival. However, a number of factors, including renal function, may affect the NT-proBNP levels. This study aims to provide a more precise way of interpreting NT-proBNP levels based on GFR, independent of age.
  
  
  METHODS
  This study includes 247 pts in whom CHF and known confounders of elevated NT-proBNP were excluded, to show the relationship of GFR in association with age. The effect of eGFR on NT-proBNP level was adjusted by dividing 1000 x log(NT-proBNP) by eGFR then further adjusting for age in order to determine a normalized NT-proBNP value.
  
  
  RESULTS
  The normalized NT-proBNP levels were affected by eGFR independent of the age of the patient.
  
  
  CONCLUSIONS
  A normalizing function based on eGFR eliminates the need for an age-based reference ranges for NT-proBNP.
authors.affiliation: Department of Pathology, New York Methodist Hospital, 506 6th Street, Brooklyn, NY 11215, USA. plbern@yahoo.com
authors.forename: Larry H
authors.initials: LH
authors.lastname: Bernstein
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Zions
authors.forename: Salman A
authors.initials: SA
authors.lastname: Haq
authors.forename: Stuart
authors.initials: S
authors.lastname: Zarich
authors.forename: James
authors.initials: J
authors.lastname: Rucinski
authors.forename: Bette
authors.initials: B
authors.lastname: Seamonds
authors.forename: Stanley
authors.initials: S
authors.lastname: Berger
authors.forename: Daniel Y
authors.initials: DY
authors.lastname: Lesley
authors.forename: William
authors.initials: W
authors.lastname: Fleischman
authors.forename: John F
authors.initials: JF
authors.lastname: Heitner
mesh_terms: D017677:Age Distribution; D000368:Aged; D004032:Diet; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000503:physiopathology; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain