Antigen-presenting cells in human immunosuppressive drug-induced gingival enlargement.
An immunoperoxidase technique was used to compare the number of CD1a+ and factor XIIIa+ dendritic cells (DCs), and CD68+ Macrophages (M) in 30 gingival samples from subjects with clinically healthy periodontitium (HP) and 10 samples from subjects with drug-induced gingival enlargement (DIGE). Fewer CD1a+ and factor XIIIa+ DCs were found in areas with inflammatory infiltration (II) of the lamina propria (LP) in the group with immunosuppressed DIGE (IDIGE) compared to the group with HP. In the sulcular and junctional/pocket epithelia, the number of CD1a+ DCs was decreased in the group with IDIGE (p<0.05). There was a tendency toward a reduced number of CD1a+ DCs and CD68+ M in areas without inflammatory infiltrate of the LP in the group with IDIGE. The alterations in the number of antigen-presenting cells (APCs) may be the reason for the decreased periodontal inflammation and breakdown clinically observed in subjects who are immunosuppressed.
Cury
Patricia R
PR
Department of Microbiology and Immunology, São Leopoldo Mandic Dental Research Center, Campinas, São Paulo, Brazil. patcury@yahoo.com
Arsati
Franco
F
de Magalhães
Marina Helena Cury Gallottini
MH
de Araújo
Vera C
VC
de Araújo
Ney S
NS
Barbuto
José Alexandre
JA
D000328:Adult; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000473:pathology*; D015703:Antigens, CD / Q000032:analysis; D018949:Antigens, CD1 / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D004846:Epithelial Attachment / Q000276:immunology / Q000473:pathology; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D026122:Factor XIIIa / Q000032:analysis; D005260:Female; D005883:Gingival Crevicular Fluid / Q000276:immunology; D005886:Gingival Hypertrophy / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010514:Periodontal Pocket / Q000276:immunology / Q000473:pathology; D010519:Periodontium / Q000276:immunology / Q000473:pathology; D000097382:CD68 Molecule
D015703:Antigens, CD; D018949:Antigens, CD1; D015214:Antigens, Differentiation, Myelomonocytic; D026122:Factor XIIIa; D007166:Immunosuppressive Agents; C419393:CD1a antigen; C067980:CD68 antigen, human; D000097382:CD68 Molecule