title: Analysis of the dose-response relationship between high-risk human papillomavirus viral load and cervical lesions.
abstract: The aims of this study were to explore the dose-response relationship between high-risk human papillomavirus (hrHPV) load and cervical lesions; the relationship between hrHPV viral load and the severity of cervical lesions; and the clinical application of the hybrid capture II (HC-II) system in the secondary prevention of cervical cancer. HrHPV viral load was detected by the HC-II system and cervical lesions were diagnosed from biopsied tissue. Curve estimation and Mantel trend analysis were used to explore the dose-response relationship between hrHPV viral load and cervical lesions. Spearman's rank correlation analysis and ordinal regression model were used for the analysis of hrHPV viral load and the severity of cervical lesions. Curve estimation showed good correlation between cervical lesion rates and hrHPV viral load (r=0.775, P=0.008); the rate of cervical lesions increased with hrHPV viral load (chi(trend)=8.000, P<0.001). Medium intensity rank correlation was found between hrHPV viral load grades and the severity of cervical lesions (r(s)=0.321, P<0.001); a correlation appeared between hrHPV viral load and the severity of cervical lesions (P<0.001). These results suggest a dose-response relationship between hrHPV viral load and the severity of cervical lesions. This dependence has important clinical applications and shows the potential value of the HC-II system in cervical cancer prevention.
authors.affiliation: Public Health School of Central South University, Changsha 410078, Hunan Province, China.
authors.forename: Min-Zhu
authors.initials: MZ
authors.lastname: Huang
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Li
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Nie
authors.forename: Xiao-Man
authors.initials: XM
authors.lastname: Jiang
authors.forename: Hui
authors.initials: H
authors.lastname: Ming
authors.forename: Deng-Qing
authors.initials: DQ
authors.lastname: Li
authors.forename: Xin-Yin
authors.initials: XY
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002681:China; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D013223:Statistics as Topic; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D019562:Viral Load; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000821:virology*
chemical_list: D004279:DNA, Viral