Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization.
The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.
Asbahr
Ana Carolina C
AC
Departamento de Farmácia, Universidade Federal do Paraná, Av. Lothario Meissner, 632, Curitiba, PR 80210-170, Brazil. acasbahr@hotmail.com
Franco
Luzia
L
Barison
Andersson
A
Silva
Caroline W P
CW
Ferraz
Humberto G
HG
Rodrigues
Letícia N C
LN
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry; D018120:Finasteride / Q000138:chemical synthesis / Q000737:chemistry*; D005612:Freeze Drying; D009682:Magnetic Resonance Spectroscopy; D011108:Polymers / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
D011108:Polymers; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D018120:Finasteride; D048271:Chitosan; D011205:Povidone