The evolving understanding of COPI vesicle formation.
The coat protein I (COPI) complex is considered to be one of the best-characterized coat complexes. Studies on how it functions in vesicle formation have provided seminal contributions to the general paradigm in vesicular transport that the ADP-ribosylation factor (ARF) small GTPases are key regulators of coat complexes. Here, we discuss emerging evidence that suggests the need to revise some long-held views on how COPI vesicle formation is achieved.
Hsu
Victor W
VW
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA. vhsu@rics.bwh.harvard.edu
Lee
Stella Y
SY
Yang
Jia-Shu
JS
D020727:ADP-Ribosylation Factors / Q000378:metabolism; D000818:Animals; D020755:Coat Protein Complex I / Q000378:metabolism / Q000502:physiology*; D018699:Coated Vesicles / Q000378:metabolism*; D006801:Humans
D020755:Coat Protein Complex I; D020727:ADP-Ribosylation Factors