title: Altered brain activation during response inhibition in obstructive sleep apnea.
abstract: This study examined response inhibition during a Go-NoGo task in individuals with obstructive sleep apnea (OSA). Fourteen OSA patients and 14 controls were studied with functional magnetic resonance imaging. Compared to controls, the OSA group showed more false positives (error of commission) during the NoGo trials with decreased brain activation in the left postcentral gyrus, cingulate gyrus and inferior parietal lobe, as well as right insula and putamen. This is consistent with previous findings of impaired performance and decreased brain activation in OSA patients during a working memory task, suggesting that compromised brain function in response to cognitive challenges may underlie some of the cognitive deficits seen in patients with OSA.
authors.affiliation: Department of Psychiatry, University of California, 3350 La Jolla Village Dr., San Diego, CA 92161, USA. layalon@ucsd.edu
authors.forename: Liat
authors.initials: L
authors.lastname: Ayalon
authors.forename: Sonia
authors.initials: S
authors.lastname: Ancoli-Israel
authors.forename: Sean Pa
authors.initials: SP
authors.lastname: Drummond
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D001288:Attention / Q000502:physiology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009042:Motivation; D017286:Polysomnography; D011597:Psychomotor Performance / Q000502:physiology*; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology* / Q000523:psychology