title: The headache of a hyperactive calcium channel.
abstract: Migraine is thought to be triggered by excessive neocortical neuronal excitability that leads to cortical spreading depression. In this issue of Neuron, Tottene et al. study a mouse model of familial hemiplegic migraine type 1, and provide evidence for the hyperactivity of P/Q-type calcium channel-mediated cortical glutamatergic synaptic transmission as an underlying mechanism for the susceptibility of cortical spreading depression initiation in migraine disorders.
authors.affiliation: Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Mingshan
authors.initials: M
authors.lastname: Xue
authors.forename: Christian
authors.initials: C
authors.lastname: Rosenmund
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000235:genetics*; D006261:Headache / Q000235:genetics*; D009154:Mutation
chemical_list: D015220:Calcium Channels