Molecular genetics of atherosclerosis.
Atherosclerosis is a complex multifocal arterial disease involving interactions of multiple genetic and environmental factors. Advances in techniques of molecular genetics have revealed that genetic polymorphisms significantly influence susceptibility to atherosclerotic vascular diseases. A large number of candidate genes, genetic polymorphisms and susceptibility loci associated with atherosclerotic diseases have been identified in recent years and their number is rapidly increasing. In this review we focus on some of the major candidate genes and genetic polymorphisms associated with human atherosclerotic vascular diseases.
Roy
Himadri
H
Department of Molecular Medicine and Biotechnology, A.I. Virtanen Institute, University of Kuopio, Kuopio, Finland. himadri.roy@uku.fi
Bhardwaj
Shalini
S
Yla-Herttuala
Seppo
S
D050197:Atherosclerosis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000235:genetics; D050356:Lipid Metabolism / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics; D011110:Polymorphism, Genetic