The use of voriconazole in the management of post-penetrating keratoplasty Paecilomyces keratitis.
OBJECTIVE
The aim of this study was to report successful treatment of Paecilomyces lilacinus keratitis with voriconazole.


METHODS
Case series.


RESULTS
Two patients with history of penetrating keratoplasty (PKP) presented with progressive P. lilacinus keratitis. Initial medical treatment failed to control the infection. The first patient received topical voriconazole at the early stage of infection. The second patient required therapeutic PKP and intracameral voriconazole was given at the end of the surgery. He developed presumed secondary endophthalmitis and was treated aggressively with intravitreal and systemic voriconazole. Both the patients responded well to the treatment and achieved complete recovery.


CONCLUSIONS
These cases illustrated effectiveness and safety of various modes of voriconazole administration in treating P. lilacinus ocular infection.
Deng
Sophie X
SX
The Jules Stein Eye Institute, University of California, Los Angeles, California, USA. sdeng@jsei.ucla.edu
Kamal
Khairidzan M
KM
Hollander
David A
DA
D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004333:Drug Administration Routes; D009877:Endophthalmitis / Q000188:drug therapy; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007634:Keratitis / Q000188:drug therapy* / Q000601:surgery; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D010143:Paecilomyces; D011743:Pyrimidines / Q000008:administration & dosage / Q000627:therapeutic use*; D014230:Triazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole