title: Structure revision of the lantibiotic 97518.
abstract: The lantibiotic 97518, produced by a Planomonospora sp., was reported as a 2194 Da polypeptide comprising 24 amino acid residues with five thioether bridges. It was assigned to the mersacidin subgroup of type B lantibiotics by Castiglione et al. (Biochemistry 2007, 46, 5884-5897) and named planosporicin. New analytical, chemical, and genetic data and reinterpretation of the published NMR chemical shifts enable structure revision of 97518. The resulting revision of the 97518 structure involves both a shift of two amino acids and a reorganization of two thioether bridges. With this revision, the lantibiotic 97518 becomes a clear member of the nisin subgroup of compounds.
authors.affiliation: NAICONS, New Anti-Infective CONSortium, Milan, Italy. SMaffioli@naicons.com
authors.forename: Sonia I
authors.initials: SI
authors.lastname: Maffioli
authors.forename: Donatella
authors.initials: D
authors.lastname: Potenza
authors.forename: Francesca
authors.initials: F
authors.lastname: Vasile
authors.forename: Marilenia
authors.initials: M
authors.lastname: De Matteo
authors.forename: Margherita
authors.initials: M
authors.lastname: Sosio
authors.forename: Barbara
authors.initials: B
authors.lastname: Marsiglia
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Rizzo
authors.forename: Carlo
authors.initials: C
authors.lastname: Scolastico
authors.forename: Stefano
authors.initials: S
authors.lastname: Donadio
mesh_terms: D000192:Actinomycetales / Q000737:chemistry*; D000595:Amino Acid Sequence; D001430:Bacteriocins / Q000737:chemistry*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry
chemical_list: D001430:Bacteriocins; D010455:Peptides; C520832:planosporicin