Successful treatment with intravenous colistin for sinusitis, orbital cellulites, and pneumonia caused by multidrug-resistant metallo-beta-lactamase-producing Pseudomonas aeruginosa in a patient with acute myeloid leukemia.
The incidence of multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing P. aeruginosa has increased worldwide. The treatment options are limited for infectious diseases caused by these two organisms. The use of colistin has been of recent interest in cases involving both types. We report the case of a 74-year-old man with acute myeloid leukemia who was successfully treated with intravenous colistin for maxillary sinusitis and orbital cellulites due to MBL-producing MDRPA during neutropenia, and then for pneumonia caused by the bacteria after the recovery of neutrophil counts.
Saito
Takashi
T
Department of Clinical Laboratory Medicine, Kyoto University Hospital, Shougoin, Kyoto, Japan. saitota@kuhp.kyoto-u.ac.jp
Takaori-Kondo
Akifumi
A
Tashima
Masaharu
M
Yamashita
Kohei
K
Iinuma
Yoshitsugu
Y
Takakura
Shunji
S
Nagao
Miki
M
Ichinohe
Tatsuo
T
Ishikawa
Takayuki
T
Uchiyama
Takashi
T
Ichiyama
Satoshi
S
D000368:Aged; D000900:Anti-Bacterial Agents; D003091:Colistin / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy / Q000382:microbiology; D054517:Orbital Cellulitis / Q000188:drug therapy / Q000382:microbiology; D011014:Pneumonia / Q000188:drug therapy / Q000382:microbiology; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011550:Pseudomonas aeruginosa; D016896:Treatment Outcome; D001618:beta-Lactamases
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; D003091:Colistin