title: BioXyce: an engineering platform for the study of cellular systems.
abstract: Researchers use constructs from the field of electrical engineering for the modelling and analysis of biological systems, but few exploit parallels between electrical and biological circuits for simulation purposes. The authors discuss the development of BioXyce, a circuit-based biological simulation platform that uses Xyce, a large-scale electrical circuit simulator, as its simulation engine. BioXyce is capable of simulating whole-cell and multicellular systems. Simulation results for the central metabolism in Escherichia coli K12 and cellular differentiation in Drosophila sp. are presented.
authors.affiliation: Sandia National Laboratories, Discrete Mathematics and Complex Systems Department, Albuquerque, NM 87185, USA. eemay@sandia.gov
authors.forename: E E
authors.initials: EE
authors.lastname: May
authors.forename: R L
authors.initials: RL
authors.lastname: Schiek
mesh_terms: D000465:Algorithms; D000818:Animals; D001669:Biochemical Phenomena; D002454:Cell Differentiation; D002468:Cell Physiological Phenomena; D003198:Computer Simulation; D004330:Drosophila / Q000502:physiology; D055590:Electromagnetic Phenomena; D048168:Escherichia coli K12 / Q000502:physiology; D053858:Metabolic Networks and Pathways / Q000502:physiology; D008954:Models, Biological; D049490:Systems Biology / Q000379:methods*