title: Soluble endothelial protein C receptor levels in healthy population.
abstract: Increased levels of sEPCR lead to dysfunction of EPCR-mediated coagulation. The aim of this present study was to determine plasma sEPCR levels in a group of Turkish healthy population including both adults and children. The study population consisted of 230 healthy individuals (108 children and 122 adults) having no acute or chronic disease. Plasma sEPCR levels were measured with ELISA. Analysis revealed a bimodal distribution in both groups. There was a negative relationship between sEPCR levels and the age of individuals (r = -0.385, P = 0.0001). The sEPCR levels of children were found significantly higher than that of adults (P < 0.001). This study is the first study to determine the relationship of sEPCR levels and terms of age. Higher levels of sEPCR may suggest a regulation mechanism for the protein C anticoagulation system over the first years of life. Further studies should be conducted to evaluate the physiological importance and molecular mechanism of increased sEPCR levels in children.
authors.affiliation: Department of Pediatrics, Division of Social Pediatrics, Ankara University School of Medicine, Ankara, Turkey. simsekfiliz@hotmail.com
authors.forename: Filiz Simsek
authors.initials: FS
authors.lastname: Orhon
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ergun
authors.forename: Yonca
authors.initials: Y
authors.lastname: Egin
authors.forename: Betul
authors.initials: B
authors.lastname: Ulukol
authors.forename: Sevgi
authors.initials: S
authors.lastname: Baskan
authors.forename: Nejat
authors.initials: N
authors.lastname: Akar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood; D015703:Antigens, CD / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D000074283:Endothelial Protein C Receptor; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000097:blood*; D012016:Reference Values; D012737:Sex Factors; D014421:Turkey; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D000074283:Endothelial Protein C Receptor; C478370:PROCR protein, human; D011956:Receptors, Cell Surface