Paraneoplastic sensory neuropathy associated with small cell carcinoma of the gallbladder.
A small number of patients with carcinoma of the gallbladder can present with a variety of paraneoplastic syndromes, including the Cushing syndrome, hypercalcemia, acanthosis nigricans, bullous pemphigoid, dermatomyositis, and the Leser-Trélat sign. We report on what appears to be the first case of a patient, a 48-year-old woman, with anti-Hu paraneoplastic sensory neuropathy and small cell carcinoma of the gallbladder. The patient's neurologic symptoms preceded the diagnosis of small cell carcinoma by 11 months. These symptoms improved after surgical removal of the tumor and chemotherapy. The small cell carcinoma was relatively small and was not associated with gallstones. In spite of the small size of the tumor, it metastasized to a celiac lymph node and probably to the liver. Anti-Hu paraneoplastic sensory neuropathy should be added to the list of paraneoplastic syndromes associated with small cell carcinoma of the gallbladder.
Uribe-Uribe
Norma O
NO
Department of Pathology, Instituto Nacional de Ciencias Medicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Jimenez-Garduño
Aura Matilde
AM
Henson
Donald E
DE
Albores-Saavedra
Jorge
J
D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D015153:Blotting, Western; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D051959:ELAV Proteins / Q000276:immunology; D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis / Q000473:pathology; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000209:etiology / Q000473:pathology*
D001323:Autoantibodies; D051959:ELAV Proteins