title: Cerebral MRI lesions and anti-tumor necrosis factor-alpha therapy.
abstract: We discuss two cases receiving different anti-tumornecrosis-factor alpha antagonists (anti-TNF-alpha); one for psoriatic arthritis (PA) and the other for ankylosing spondylitis (AS). Due to neurological symptoms cerebral magnetic resonance imaging (MRI) was performed and cerebral lesions were detected. Our interpretations of these cerebral lesions and the resulting diagnostic and therapeutic consequences are presented in regard of data published in the medical literature.
authors.affiliation: Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany. alexander.winkelmann@med.uni-rostock.de
authors.forename: Alexander
authors.initials: A
authors.lastname: Winkelmann
authors.forename: Robert
authors.initials: R
authors.lastname: Patejdl
authors.forename: Sabine
authors.initials: S
authors.lastname: Wagner
authors.forename: Reiner
authors.initials: R
authors.lastname: Benecke
authors.forename: Uwe Klaus
authors.initials: UK
authors.lastname: Zettl
mesh_terms: D000328:Adult; D000906:Antibodies / Q000009:adverse effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000276:immunology*
chemical_list: D000906:Antibodies; D014409:Tumor Necrosis Factor-alpha