Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.
Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).
Lee
Yan
Y
Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
Ishii
Takehiko
T
Cabral
Horacio
H
Kim
Hyun Jin
HJ
Seo
Ji-Hun
JH
Nishiyama
Nobuhiro
N
Oshima
Hiroki
H
Osada
Kensuke
K
Kataoka
Kazunori
K
D000577:Amides / Q000737:chemistry; D000818:Animals; D001224:Aspartic Acid / Q000737:chemistry; D045744:Cell Line, Tumor; D002949:Citraconic Anhydrides / Q000737:chemistry*; D045304:Cytochromes c / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D003593:Cytoplasm / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D006321:Heart; D006736:Horses; D006801:Humans; D007477:Ions / Q000737:chemistry; D008823:Micelles; D009206:Myocardium / Q000201:enzymology; D011092:Polyethylene Glycols / Q000737:chemistry
D000577:Amides; D002949:Citraconic Anhydrides; D004337:Drug Carriers; D007477:Ions; D008823:Micelles; D001224:Aspartic Acid; D011092:Polyethylene Glycols; D045304:Cytochromes c