title: A prospective 7-year survey on central venous catheter-related complications at a single pediatric hospital.
abstract: The aims of this study were to assess the incidence and risk factors of major central venous catheter (CVC)-related complications in a large cohort of children affected by oncological, hematological, or immunological diseases in a 7-year prospective observational study at a single center. Nine hundred fifteen CVCs were inserted in 748 children for a total period of 307,846 CVC-days. Overall, 298 complications were documented with a complication rate of 0.97/1,000 CVC-days: 105 mechanical complications (dislocations 0.30/1,000 CVC-days, ruptures 0.04/1,000 CVC-days), 174 infections (bloodstream infections 0.46/1,000 CVC-days, tunnel infections 0.10/1,000 CVC-days), and 19 thrombosis (0.06/1,000 CVC-days). Significant risk factors were: diagnosis of acute lymphoblastic leukemia (ALL) and age <or=3 years for dislocations; nonmalignant disease for ruptures; ALL for thrombosis; double-lumen and partially implanted CVCs for bloodstream infections; age <or=3 years for tunnel infections. In conclusion, the rate of CVC-related complications in children was lower than that usually reported.
authors.affiliation: Department of Pediatrics, University of Turin, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Pinon
authors.forename: S
authors.initials: S
authors.lastname: Bezzio
authors.forename: P A
authors.initials: PA
authors.lastname: Tovo
authors.forename: F
authors.initials: F
authors.lastname: Fagioli
authors.forename: L
authors.initials: L
authors.lastname: Farinasso
authors.forename: R
authors.initials: R
authors.lastname: Calabrese
authors.forename: M
authors.initials: M
authors.lastname: Marengo
authors.forename: M
authors.initials: M
authors.lastname: Giacchino
mesh_terms: D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002648:Child; D004867:Equipment Design; D005260:Female; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy*; D006776:Hospitals, Pediatric; D006801:Humans; D015994:Incidence; D007239:Infections / Q000453:epidemiology* / Q000382:microbiology; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000628:therapy*; D011446:Prospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000453:epidemiology; D056824:Upper Extremity Deep Vein Thrombosis / Q000453:epidemiology*