title: Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women.
abstract: CYP1B1 is a key enzyme involved in estrogen metabolism and may play an important role in the development and progression of breast cancer. In a population-based case-control study, we examined eight CYP1B1 haplotype-tagging single nucleotide polymorphisms in relation to invasive breast cancer risk. Analyses were based on 1,655 cases and 1,470 controls; all women were Caucasian. Among the individual single nucleotide polymorphisms, one (rs9341266) was associated with increased risk of breast cancer (P(trend) = 0.021), although the association was no longer significant after adjusting for multiple tests. A marginally significant haplotype effect was identified (P(global) = 0.015), with significant associations identified for 2 uncommon haplotypes comprising 4% of the controls. Results suggest that genetic variation in CYP1B1 has at most a minor influence on breast cancer susceptibility among Caucasian women.
authors.affiliation: H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
authors.forename: Yifan
authors.initials: Y
authors.lastname: Huang
authors.forename: Amy
authors.initials: A
authors.lastname: Trentham-Dietz
authors.forename: Montserrat
authors.initials: M
authors.lastname: García-Closas
authors.forename: Polly A
authors.initials: PA
authors.lastname: Newcomb
authors.forename: Linda
authors.initials: L
authors.lastname: Titus-Ernstoff
authors.forename: John M
authors.initials: JM
authors.lastname: Hampton
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Jonathan L
authors.initials: JL
authors.lastname: Haines
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Egan
mesh_terms: D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D044465:White People / Q000235:genetics*; D055815:Young Adult
chemical_list: D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1