title: Silicon-substituted hydroxyapatite composite coating by using vacuum-plasma spraying and its interaction with human serum albumin.
abstract: The incorporation of silicon can improve the bioactivity of hydroxyapatite (HA). Silicon-substituted HA (Ca(10)(PO(4))(6-x )(SiO(4))( x )(OH)(2-x ), Si-HA) composite coatings on a bioactive titanium substrate were prepared by using a vacuum-plasma spraying method. The surface structure was characterized by using XRD, SEM, XRF, EDS and FTIR. The bond strength of the coating was investigated and XRD patterns showed that Ti/Si-HA coatings were similar to patterns seen for HA. The only different XRD pattern was a slight trend toward a smaller angle direction with an increase in the molar ratio of silicon. FTIR spectra showed that the most notable effect of silicon substitution was that -OH group decreased as the silicon content increased. XRD and EDS elemental analysis indicated that the content of silicon in the coating was consistent with the silicon-substituted hydroxyapatite used in spraying. A bioactive TiO(2) coating was formed on an etched surface of Ti, and the etching might improve the bond strength of the coatings. The interaction of the Ti/Si-HA coating with human serum albumin (HSA) was much greater than that of the Ti/HA coating. This might suggest that the incorporation of silicon in HA can lead to significant improvements in the bioactive performance of HA.
authors.affiliation: Department of Material Science and Engineering, Shjiazhuang Railway Institute, Shijiazhuang, Hebei Province, China. xfj66@126.com
authors.forename: Feng-Juan
authors.initials: FJ
authors.lastname: Xiao
authors.forename: Lei
authors.initials: L
authors.lastname: Peng
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Li-Jiang
authors.initials: LJ
authors.lastname: Yun
mesh_terms: D000268:Adhesiveness / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry*; D006801:Humans; D008422:Materials Testing; D008669:Metallurgy / Q000295:instrumentation / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D012709:Serum Albumin / Q000494:pharmacology*; D012825:Silicon / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties / Q000187:drug effects; D014618:Vacuum; D014961:X-Ray Diffraction
chemical_list: D020099:Coated Materials, Biocompatible; D012709:Serum Albumin; D017886:Durapatite; D012825:Silicon