title: [Cancer chemotherapy utilizing nanotechnology].
abstract: Various attempts are under way to apply nanotechnology, in which remarkable progress has been made in recent years, to the diagnosis and treatment of cancer. For treating solid tumors, a system has been developed for more efficiently delivering nano-scale polymeric formulations to the tumors, utilizing the Enhanced Permeability and Retention( EPR)effect due to the characteristics of the tumor vascular system. Such nano-scale devices include a liposomal formulation, albumin-bound formulation and polymer micellar formulation, and each is currently under clinical development; some of these, such as doxorubicin-containing liposome(Doxyl), are already used in clinical practice. This paper describes the characterization of these nano-scale devices and ongoing clinical trials.
authors.affiliation: General Inpatient Division, National Cancer Center Hospital.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hamaguchi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use*; D002463:Cell Membrane Permeability; D008823:Micelles; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D011108:Polymers / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D011108:Polymers