The association of diastolic dysfunction and circadian variation of blood pressure in prehypertension.
OBJECTIVE
In this study, we aimed to investigate the relationship between circadian blood pressure variations and left ventricular diastolic functions in patients with prehypertension.


METHODS
The study population consisted of 48 patients with nondipper prehypertension and 60 patients with dipper prehypertension. Conventional diastolic function parameters, tissue Doppler, and color M-mode flow parameters were obtained during echocardiographic examination.


RESULTS
The early diastolic septal myocardial velocity (E' septal) and early diastolic lateral myocardial velocity (E' lateral) were significantly decreased in nondippers (7.0 +/- 1.2 cm/s vs 9.2 +/- 2.3 cm/s, P < .01 and 11.4 +/- 2.4 cm/s vs 10.2 +/- 2.4 cm/s, P < .05). Mitral propagation velocity (Vp) was also significantly lower in nondippers than in dippers (48.2 +/- 8.3 cm/s vs 61.3 +/- 25.2 cm/s, P < .05). The ratio of E/E' septal, E/E' lateral, and E/Vp was significantly different between dippers and nondippers.


CONCLUSIONS
Diastolic parameters were impaired in nondipper prehypertensive patients. This may indicate diminished diastolic function that may contribute to hypertension in the near future.
Yeter
Ekrem
E
Atatürk Education and Research Hospital, Department of Cardiology, Ankara, Turkey. ekremyeter@hotmail.com
Akçay
Murat
M
Keleş
Telat
T
Durmaz
Tahir
T
Bayram
Nihal Akar
NA
Ozdemir
Levent
L
Yüksel
Isa
I
Bozkurt
Engin
E
D001794:Blood Pressure; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D018487:Ventricular Dysfunction, Left / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology*