Decreased viral load and symptoms of polyomavirus-associated chronic interstitial cystitis after intravesical cidofovir treatment.
Interstitial cystitis causes disabling bladder pain and is usually diagnosed in the absence of infection. We describe a patient with interstitial cystitis who had high urinary levels of polyomavirus that decreased dramatically after initiation of intravesical cidofovir treatment; the patient also showed substantial improvement in symptoms. Another patient had milder symptoms of cystitis and intermittent polyomavirus shedding. Polyomaviruses, particularly BK virus, may cause some cases of interstitial cystitis.
Eisen
Damon P
DP
Victorian Infectious Diseases Service, Royal Melbourne Hospital, Parkville, Australia. damon.eisen@mh.org.au
Fraser
Ian R
IR
Sung
Linda M
LM
Finlay
Moira
M
Bowden
Scott
S
O'Connell
Helen
H
D000283:Administration, Intravesical; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000077404:Cidofovir; D018856:Cystitis, Interstitial / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000008:administration & dosage / Q000627:therapeutic use*; D011120:Polyomavirus / Q000302:isolation & purification*; D027601:Polyomavirus Infections / Q000188:drug therapy / Q000503:physiopathology* / Q000821:virology; D014556:Urine / Q000821:virology*
D000998:Antiviral Agents; D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir