Dynamic kinetic resolution of beta-keto sulfones via asymmetric transfer hydrogenation.
The dynamic kinetic resolution of beta-keto sulfones was achieved via asymmetric transfer hydrogenation using (S,S)-RuCl[N-(tosyl)-1,2-diphenylethylenediamine](p-cymene) in the presence of formic acid and triethylamine afforded the desired products in good yield with up to >99 : 1 dr and high ee up to >99%.
Ding
Zhenhua
Z
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Soochow University, Suzhou 215123, China.
Yang
Jin
J
Wang
Ting
T
Shen
Zongxuan
Z
Zhang
Yawen
Y