title: Liver cell adenoma showing sequential alteration of radiological findings suggestive of well-differentiated hepatocellular carcinoma.
abstract: A liver tumor 35 mm in diameter was found incidentally in a 40-year-old woman who had no history of liver diseases or the use of oral contraceptives. Radiological diagnostics showed the typical findings of liver cell adenoma (LCA). Dynamic computed tomography revealed that the tumor showed a homogenous enhancement in the arterial phase and almost the same enhancement as the surrounding liver parenchyma in the delayed phase. The tumor was found to contain fat on magnetic resonance imaging. A benign fat containing liver tumor was suggested. However, radiological findings altered, which caused us to suspect that a well-differentiated hepatocellular carcinoma (HCC) containing fat was becoming dedifferentiated. Partial hepatectomy was performed and the pathological findings showed the typical findings of LCA. This case was an extremely rare LCA, which had no background of risk for LCA and developed the sequential alteration of the radiological findings to suspect well-differentiated HCC.
authors.affiliation: Division of Gastroenterology, Graduate School of Medicine, Tohoku University, Sendai 980-8574, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kogure
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Ueno
authors.forename: Satoshi
authors.initials: S
authors.lastname: Sekiguchi
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ishida
authors.forename: Takehiko
authors.initials: T
authors.lastname: Igarashi
authors.forename: Yuta
authors.initials: Y
authors.lastname: Wakui
authors.forename: Takao
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Tooru
authors.initials: T
authors.lastname: Shimosegawa
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome