title: Relation between abnormalities in circadian blood pressure rhythm and target organ damage in normotensives.
abstract: BACKGROUND
  To determine the individual effect of abnormalities in blood pressure (BP) circadian rhythm (non-dipping status (NDS), increased morning BP (MBP) or increased MBP surge (MBPS)) on target organ damage (TOD) and which of these is more closely related to TOD in normotensives.
  
  
  RESULTS
  The 24-h ambulatory BP monitoring (ABPM) and echocardiography were performed and urinary albumin excretion (UAE) was measured in 47 dipper (28 women, mean age 45.8 +/- 9.3) and 32 non-dipper (25 women, mean age 49.1 +/- 8.3 years) normotensive subjects. The left ventricular mass index (LVMI) was higher in non-dipper group (103.8 +/- 24.1 vs 91.6 +/- 23.5 g/m2, P=0.03). UAE in non-dipper group was higher, but the difference between the two was not statistically significant (18.9 [10.3, 28.9] vs 14.1 [7.5, 23.8], P=0.11). In multivariate analysis, both LVMI and UAE were affected by NDS and MBP independent of other confounding variables (for LVMI; Coefficient =0.27, P=0.01 and Coefficient =0.37, P=0.001, respectively, and for UAE; Coefficient =0.27, P=0.02 and Coefficient =0.28, P=0.01, respectively).
  
  
  CONCLUSIONS
  It may be postulated that increased night and MBP are the factors that cause TOD, and it seems reasonable to attempt to restore normal diurnal rhythm of the BP even in normotensive subjects.
authors.affiliation: Department of Cardiology, Meram Medical School of Selcuk University, Konya, Turkey. asoylu44@gmail.com
authors.forename: Ahmet
authors.initials: A
authors.lastname: Soylu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Yazici
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Duzenli
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tokac
authors.forename: Kurtuluş
authors.initials: K
authors.lastname: Ozdemir
authors.forename: Hasan
authors.initials: H
authors.lastname: Gok
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000209:etiology / Q000503:physiopathology; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002940:Circadian Rhythm; D004452:Echocardiography; D005260:Female; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000503:physiopathology / Q000652:urine; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment