title: Rivastigmine in Chinese patients with subcortical vascular dementia.
abstract: BACKGROUND
  We explored the efficacy and tolerability of rivastigmine among Chinese patients with subcortical vascular dementia.
  
  
  METHODS
  Forty subjects were randomized to either placebo (n = 20) or rivastigmine (n = 20) in a double-blind 26-week trial. Outcome measures were cognition (mini-mental state examination, frontal assessment battery), neuropsychiatric inventory (NPI), instrumental activities of daily living, clinical dementia rating scale, and adverse events.
  
  
  RESULTS
  No statistical significant benefit could be observed in the active group in any of the efficacy measures. A trend favoring active group was observed only in the NPI subscore of irritability (p = 0.066) and aberrant motor behavior (p = 0.068). Withdrawal rate was 30% and 15% in the active and placebo group, respectively.
  
  
  CONCLUSIONS
  Among Chinese subcortical vascular dementia patients, there was no apparent cognitive benefit associated with use of rivastigmine over the 6 months period. A trend favoring rivastigmine was observed in certain behavioral measures. Rivastigmine was associated with more withdrawals relative to placebo.
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Shatin, Hong Kong, China. vctmok@cuhk.edu.hk
authors.forename: Vincent
authors.initials: V
authors.lastname: Mok
authors.forename: Adrian
authors.initials: A
authors.lastname: Wong
authors.forename: Simon
authors.initials: S
authors.lastname: Ho
authors.forename: Thomas
authors.initials: T
authors.lastname: Leung
authors.forename: Wynnie W M
authors.initials: WW
authors.lastname: Lam
authors.forename: Ka Sing
authors.initials: KS
authors.lastname: Wong