[Mitochondrial diabetes: clinical features, diagnosis and management].
Mitochondrial diabetes affects up to 1% of patients with diabetes and is often unrecognised by the physicians. Maternally inherited diabetes and deafness (MIDD) resulting from the mutation 3243A>G of the mitochondrial DNA is the most frequent mutation associated with mitochondrial diabetes. This review summarizes the range of clinical phenotypes associated with MIDD and outlines the advances in genetic diagnosis, pathogenesis and management of these patients.
Meas
T
T
hôpital Lariboisière, Paris, France. taly.meas@lrb.aphp.fr
Laloi-Michelin
M
M
Virally
M
M
Ambonville
C
C
Kevorkian
J-P
JP
Guillausseau
P-J
PJ
D017668:Age of Onset; D004272:DNA, Mitochondrial / Q000235:genetics*; D003638:Deafness / Q000235:genetics; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D014644:Genetic Variation; D018392:Genomic Imprinting; D006801:Humans; D008928:Mitochondria / Q000235:genetics*; D028361:Mitochondrial Diseases / Q000175:diagnosis / Q000628:therapy; D010375:Pedigree; D010641:Phenotype; D017354:Point Mutation; D012164:Retinal Diseases / Q000235:genetics
D004272:DNA, Mitochondrial