title: Scatter-based magnetic resonance elastography.
abstract: Elasticity is a sensitive measure of the microstructural constitution of soft biological tissues and increasingly used in diagnostic imaging. Magnetic resonance elastography (MRE) uniquely allows in vivo measurement of the shear elasticity of brain tissue. However, the spatial resolution of MRE is inherently limited as the transformation of shear wave patterns into elasticity maps requires the solution of inverse problems. Therefore, an MRE method is introduced that avoids inversion and instead exploits shear wave scattering at elastic interfaces between anatomical regions of different shear compliance. This compliance-weighted imaging (CWI) method can be used to evaluate the mechanical consistency of cerebral lesions or to measure relative stiffness differences between anatomical subregions of the brain. It is demonstrated that CWI-MRE is sensitive enough to reveal significant elasticity variations within inner brain parenchyma: the caudate nucleus (head) was stiffer than the lentiform nucleus and the thalamus by factors of 1.3 +/- 0.1 and 1.7 +/- 0.2, respectively (P < 0.001). CWI-MRE provides a unique method for characterizing brain tissue by identifying local stiffness variations.
authors.affiliation: Department of Radiology, Charité-Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Papazoglou
authors.forename: Chao
authors.initials: C
authors.lastname: Xu
authors.forename: Uwe
authors.initials: U
authors.lastname: Hamhaber
authors.forename: Eberhard
authors.initials: E
authors.lastname: Siebert
authors.forename: Georg
authors.initials: G
authors.lastname: Bohner
authors.forename: Randolf
authors.initials: R
authors.lastname: Klingebiel
authors.forename: Jürgen
authors.initials: J
authors.lastname: Braun
authors.forename: Ingolf
authors.initials: I
authors.lastname: Sack
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D004453:Echoencephalography; D004548:Elasticity; D054459:Elasticity Imaging Techniques / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology; D009422:Nervous System Diseases / Q000000981:diagnostic imaging; D019047:Phantoms, Imaging; D015203:Reproducibility of Results