title: A coding SNP of LHX4 gene is associated with body weight and body length in bovine.
abstract: Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency. In this study, the polymorphism of LHX4-HaeIII locus was revealed in 822 individuals from four Chinese cattle breeds. The PCR-RFLP analysis showed that there were three genotypes: GG, GA, AA. The frequencies of genotype GG ranged from 0.6620 to 0.9789 in analyzed populations. The genotypic frequencies of LHX4 locus in the four populations all agreed with Hardy-Weinberg equilibrium (P > 0.05). Distributions of genotypic frequencies of different breeds (QC, NY, JX, CH) at this locus were found to be significantly different based on a chi(2) test (P < 0.001). The genetic diversity analysis revealed the JX cattle possessed intermediate genetic diversity, and the other three Chinese cattle breeds belonged to poor genetic diversity. Correlation analysis with growth traits in the NY breed indicated that: the animals with genotype GA had greater body weight than those with genotype GG (P < 0.05); the animals with GA genotype owned significantly longer body length than the ones with GG genotype (P < 0.05) at 18 and 24 months.
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, Shaanxi, China. rengang666@yahoo.com.cn
authors.forename: G
authors.initials: G
authors.lastname: Ren
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: L Z
authors.initials: LZ
authors.lastname: Zhang
authors.forename: X Y
authors.initials: XY
authors.lastname: Lan
authors.forename: T B
authors.initials: TB
authors.lastname: Wei
authors.forename: M J
authors.initials: MJ
authors.lastname: Li
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jing
authors.forename: C Z
authors.initials: CZ
authors.lastname: Lei
authors.forename: J Q
authors.initials: JQ
authors.lastname: Wang
mesh_terms: D000818:Animals; D001483:Base Sequence; D001699:Biometry; D001835:Body Weight / Q000235:genetics; D001947:Breeding; D002417:Cattle / Q000033:anatomy & histology* / Q000235:genetics* / Q000254:growth & development; D004587:Electrophoresis, Agar Gel; D005091:Exons / Q000235:genetics; D005787:Gene Frequency / Q000235:genetics; D056426:Genetic Loci / Q000235:genetics; D005838:Genotype; D018398:Homeodomain Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D018398:Homeodomain Proteins