2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.
The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated.
Weterings
Jimmy J
JJ
Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
Khan
Selina
S
van der Heden van Noort
Gerbrand J
GJ
Melief
Cornelis J M
CJ
Overkleeft
Herman S
HS
van der Burg
Sjoerd H
SH
Ossendorp
Ferry
F
van der Marel
Gijsbert A
GA
Filippov
Dmitri V
DV
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000588:Amines / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D003713:Dendritic Cells / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D051199:Toll-Like Receptor 7 / Q000819:agonists* / Q000502:physiology
D000588:Amines; D001386:Azides; D051199:Toll-Like Receptor 7; C002992:8-hydroxyadenine; D000225:Adenine