Is the use of cyanoacrylate in intestinal anastomosis a good and reliable alternative?
OBJECTIVE
The present study aims to compare strength, healing, and operation time of experimental intestinal anastomoses performed by polyglactin 910 (Vicryl; Ethicon, Edinburgh, United Kingdom) sutures with ethyl-2-cyanoacrylate glue (Pattex; Henkel, Dusseldorf, Germany).


METHODS
Ninety-six Sprague-Dawley rats were divided into 2 (groups E and L). Each group was further subdivided into 6 subgroups (EA1, EA2, EA3, EB1, EB2, EB3, LA1, LA2, LA3, LB1, LB2, LB3), each containing 8 rats. Intestinal anastomosis was performed by polyglactin 910 sutures in A subgroups and with ethyl-2-cyanoacrylate in B subgroups. The anastomosis was end to end in A1 and B1, side to side in A2 and B2, and end to side in A3 and B3. Time for anastomosis performance (AT) was recorded. In group E, bursting pressures and hydroxyproline levels were determined on the second postoperative day, whereas in group L, the same measurements were made on the sixth postoperative day. One-way analysis of variance was used for analyses of variance in the groups. Quantitative data were analyzed with Student's t test. P value was considered significant at less than .05.


RESULTS
There was no significant difference between bursting pressures of subgroup pairs on both postoperative days 2 and 6. Hydroxyproline levels and AT were significantly better in B subgroups.


CONCLUSIONS
Better healing, shorter AT, and equal strength were achieved with ethyl-2-cyanoacrylate compared with polyglactin 910 sutures in intestinal anastomosis in the experimental setting.
Elemen
Levent
L
Department of Pediatric Surgery, Medical Faculty, Kocaeli University, Kocaeli, Turkey.
Sarimurat
Nuvit
N
Ayik
Bekir
B
Aydin
Seval
S
Uzun
Hafize
H
D000269:Adhesives / Q000627:therapeutic use*; D000714:Anastomosis, Surgical; D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D007422:Intestines / Q000601:surgery*; D011098:Polyglactin 910 / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength; D014945:Wound Healing
D000269:Adhesives; D003487:Cyanoacrylates; C029054:ethyl 2-cyanoacrylate; D011098:Polyglactin 910