title: Ki-67 and outcome in clinically localised prostate cancer: analysis of conservatively treated prostate cancer patients from the Trans-Atlantic Prostate Group study.
abstract: Treatment decisions after diagnosis of clinically localised prostate cancer are difficult due to variability in tumour behaviour. We therefore examined one of the most promising biomarkers in prostate cancer, Ki-67, in a cohort of 808 patients diagnosed with prostate cancer between 1990 and 1996 and treated conservatively. Ki-67 expression was assessed immunohistochemically, in two laboratories, by two different scoring methods and the results compared with cancer-specific and overall survival. The power of the biomarker was compared with Gleason score and initial serum prostate-specific antigen (PSA). Both methods showed that Ki-67 provided additional prognostic information beyond that available from Gleason score and PSA: for the semi-quantitative method, Deltachi(2) (1 d.f.)=24.6 (P<0.0001), overall survival chi(2)=20.5 (P<0.0001), and for the quantitative method, Deltachi(2) (1 d.f.)=15.1 (P=0.0001), overall survival chi(2)=10.85 (P=0.001). Ki-67 is a powerful biomarker in localised prostate cancer and adds to a model predicting the need for radical or conservative therapy. As it is already in widespread use in routine pathology, it is confirmed as the most promising biomarker to be applied into routine practice.
authors.affiliation: The Orchid Tissue Laboratory, Centre for Molecular Oncology, Barts and The London School of Medicine and Dentistry, London, UK. D.Berney@bartsandthelondon.nhs.uk
authors.forename: D M
authors.initials: DM
authors.lastname: Berney
authors.forename: A
authors.initials: A
authors.lastname: Gopalan
authors.forename: S
authors.initials: S
authors.lastname: Kudahetti
authors.forename: G
authors.initials: G
authors.lastname: Fisher
authors.forename: L
authors.initials: L
authors.lastname: Ambroisine
authors.forename: C S
authors.initials: CS
authors.lastname: Foster
authors.forename: V
authors.initials: V
authors.lastname: Reuter
authors.forename: J
authors.initials: J
authors.lastname: Eastham
authors.forename: H
authors.initials: H
authors.lastname: Moller
authors.forename: M W
authors.initials: MW
authors.lastname: Kattan
authors.forename: W
authors.initials: W
authors.lastname: Gerald
authors.forename: C
authors.initials: C
authors.lastname: Cooper
authors.forename: P
authors.initials: P
authors.lastname: Scardino
authors.forename: J
authors.initials: J
authors.lastname: Cuzick
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology* / Q000628:therapy
chemical_list: D015415:Biomarkers; D019394:Ki-67 Antigen