title: Hairy cell leukemia-related disorders consistently show low CD27 expression.
abstract: In Japan, typical hairy cell leukemia (HCL) is rare, and HCL-Japanese variant (HCL-JV) is more common. Hairy B-cell lymphoproliferative disorder (HBLD) is another unusual disorder of polyclonal B-lymphocytosis of hairy cell appearance. In the present study, we analyzed the clinical features of 3 patients with HCL, 3 with HCL-JV, and 3 with HBLD. All HBLD patients had the DRB1*04 allele. As compared with other B-cell lymphoproliferative disorders, CD27 expression on B cells was significantly lower in all patients, ranging from 0.3% to 23.4%. Our results suggest that low CD27 expression may be a distinct feature of these HCL-related disorders.
authors.affiliation: Department of Medicine and Clinical Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Hashimoto
authors.forename: Norifumi
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Nakahashi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yokohama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Saitoh
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Handa
authors.forename: Takafumi
authors.initials: T
authors.lastname: Matsushima
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Murakami
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Nojima
authors.forename: Masamitsu
authors.initials: M
authors.lastname: Karasawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism; D059811:HLA-DRB1 Chains; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism; D007564:Japan; D007943:Leukemia, Hairy Cell / Q000208:ethnology* / Q000378:metabolism*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism; D008223:Lymphoma / Q000378:metabolism; D008224:Lymphoma, Follicular / Q000378:metabolism; D008232:Lymphoproliferative Disorders / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7 / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C527195:HLA-DRB1*04 antigen; D007143:Immunoglobulin Heavy Chains; D018127:Tumor Necrosis Factor Receptor Superfamily, Member 7