[Antimicrobial resistance of 36 strains of Helicobacter pylori in adolescents].
OBJECTIVE
To investigate the resistance of Helicobacter pylori (H. pylori) to antimicrobial agents in adolescents.


METHODS
One hundred and eight adolescents (6-18 years old) underwent a gastroscopy examination. H. pylori strains were isolated from gastric mucosa. Antimicrobial susceptibility testing was performed by means of Kirby-Baner.


RESULTS
Thirty-six H. pylori strains were identified. The resistant rate of H. pylori strains to clarithromycin, fruranzolidone and amoxicillin was 8.3%, 16.7% and 33.3%, respectively. H. pylori strains showed a high resistance to metronidazole (94.4%), while no strain was resistant to gentamicin and levofloxacin.


CONCLUSIONS
The H. pylori strains from the adolescents in Zhejiang showed a high resistance to metronidazole and amoxicillin but a low resistance to clarithromycin and fruranzolidone. All of H. pylori strains were susceptive to gentamicin and levofloxacin.
Huang
Lie-Ping
LP
Department of Pediatrics, Maternal and Child Health Care Hospital of Zhoushan, Zhoushan, Zhejiang 316000, China. huanglp816@126.com
Zhuang
Man-Li
ML
Gu
Cheng-Ping
CP
D000293:Adolescent; D000658:Amoxicillin / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D002648:Child; D017291:Clarithromycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D005260:Female; D005773:Gastroscopy; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D064704:Levofloxacin; D008297:Male; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology
D000890:Anti-Infective Agents; D008795:Metronidazole; D064704:Levofloxacin; D000658:Amoxicillin; D015242:Ofloxacin; D017291:Clarithromycin