title: Binary and ternary inclusion complexes of finasteride in HPbetaCD and polymers: preparation and characterization.
abstract: The aim of this study was to determine whether inclusion complexes between 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and finasteride (FIN) are formed, and to characterize these. Equimolar FIN/HPbetaCD solid systems in the presence or absence of 0.1% (w/v) of polyvinylpyrrolidone K30 (PVP K30) or 0.3% of chitosan were prepared by coevaporation and freeze-drying methods. The systems were characterized by phase solubility, NMR, DSC, and XRD analysis. The results suggest that true binary and ternary inclusion complexes were formed.
authors.affiliation: Departamento de Farmácia, Universidade Federal do Paraná, Av. Lothario Meissner, 632, Curitiba, PR 80210-170, Brazil. acasbahr@hotmail.com
authors.forename: Ana Carolina C
authors.initials: AC
authors.lastname: Asbahr
authors.forename: Luzia
authors.initials: L
authors.lastname: Franco
authors.forename: Andersson
authors.initials: A
authors.lastname: Barison
authors.forename: Caroline W P
authors.initials: CW
authors.lastname: Silva
authors.forename: Humberto G
authors.initials: HG
authors.lastname: Ferraz
authors.forename: Letícia N C
authors.initials: LN
authors.lastname: Rodrigues
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry; D018120:Finasteride / Q000138:chemical synthesis / Q000737:chemistry*; D005612:Freeze Drying; D009682:Magnetic Resonance Spectroscopy; D011108:Polymers / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry; D012995:Solubility; D014961:X-Ray Diffraction; D047392:beta-Cyclodextrins / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D011108:Polymers; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D018120:Finasteride; D048271:Chitosan; D011205:Povidone