title: Haemorrhagic cystitis and polyomavirus JC infection in ataxia telangiectasia.
abstract: We report the case of a young adolescent with ataxia telangiectasia (AT) and life-threatening haemorrhage from the bladder due to a combination of bladder wall telangiectasis, immunosuppressive therapy and an infection with polyomavirus JC. BK and JC are both members of the polyomavirus family. BK virus is a known cause of haemorrhagic cystitis in bone-marrow and nephropathy in kidney transplant patients, whereas JC virus is mainly associated with progressive multifocal leukoencephalopathy and only rarely found in haemorrhagic cystitis. Although opportunistic infections are uncommon in AT and virus replication was described as being down-regulated in ATM (AT mutated protein)-deficient cells, clinicians should be aware that severe haematuria in a patient with AT and undergoing immunosuppressive therapy is suggestive for polyomavirus JC-induced haemorrhagic cystitis.
authors.affiliation: Department of Pediatrics, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, Frankfurt/Main 60590, Germany. martin.christmann@kgu.de
authors.forename: Martin
authors.initials: M
authors.lastname: Christmann
authors.forename: Sonja
authors.initials: S
authors.lastname: Heitkamp
authors.forename: Evelyn
authors.initials: E
authors.lastname: Lambrecht
authors.forename: Kristina
authors.initials: K
authors.lastname: Doerries
authors.forename: Ralf
authors.initials: R
authors.lastname: Schubert
authors.forename: Stefan
authors.initials: S
authors.lastname: Zielen
mesh_terms: D000293:Adolescent; D001260:Ataxia Telangiectasia / Q000150:complications*; D003556:Cystitis / Q000150:complications* / Q000821:virology; D017809:Fatal Outcome; D006470:Hemorrhage / Q000150:complications* / Q000821:virology; D006801:Humans; D007577:JC Virus; D008297:Male; D027601:Polyomavirus Infections / Q000150:complications*; D014412:Tumor Virus Infections / Q000150:complications*