Cancer gene discovery in mouse and man.
The elucidation of the human and mouse genome sequence and developments in high-throughput genome analysis, and in computational tools, have made it possible to profile entire cancer genomes. In parallel with these advances mouse models of cancer have evolved into a powerful tool for cancer gene discovery. Here we discuss the approaches that may be used for cancer gene identification in both human and mouse and discuss how a cross-species 'oncogenomics' approach to cancer gene discovery represents a powerful strategy for finding genes that drive tumourigenesis.
Mattison
Jenny
J
Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1HH, UK.
van der Weyden
Louise
L
Hubbard
Tim
T
Adams
David J
DJ
D000818:Animals; D055028:Comparative Genomic Hybridization; D004251:DNA Transposable Elements; D044127:Epigenesis, Genetic; D018628:Gene Dosage; D052138:Genes, Neoplasm; D005818:Genetic Engineering; D006801:Humans; D051379:Mice; D016254:Mutagenesis, Insertional; D009369:Neoplasms / Q000235:genetics*
D004251:DNA Transposable Elements