Direct catalytic asymmetric synthesis of highly functionalized 2-methylchroman-2,4-diols via Barbas-list aldol reaction.
A practical and sustainable chemical process for the synthesis of highly substituted aldol<-->lactol products was achieved for the first time through the asymmetric Barbas-List aldol (BLA) reaction of 2-hydroxybenzaldehydes with acetone in the presence of a catalytic amount of trans-4-OH-L-proline (see scheme).
Ramachary
Dhevalapally B
DB
School of Chemistry, University of Hyderabad, Hyderabad, India.
Sakthidevi
Rajasekar
R
D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism
D000447:Aldehydes; D002839:Chromans; D011392:Proline