Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea.
Four new xanthones, butyraxanthones A-D (1-4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5-10) and a triterpenoid (lupeol). The structures of 1-4 were established by spectroscopic methods. Compounds 1-10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast cancer cell line (MCF-7). Nearly all of these xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity.
Zelefack
Fabien
F
UMR 5557 CNRS, Département de Pharmacognosie, Faculté de Pharmacie, Université de Lyon, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France.
Guilet
David
D
Fabre
Nicolas
N
Bayet
Christine
C
Chevalley
Séverine
S
Ngouela
Silvère
S
Lenta
Bruno Ndjakou
BN
Valentin
Alexis
A
Tsamo
Etienne
E
Dijoux-Franca
Marie-Geneviève
MG
D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002163:Cameroon; D002738:Chloroquine / Q000494:pharmacology; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones; D002738:Chloroquine