Selective adsorption of DNA on chiral surfaces: supercoiled or relaxed conformation.
The right fit: Plasmid DNA molecules show chirality-dependent interaction with gold surfaces modified by L and D N-isobutyrylcysteine. Relaxed DNA molecules have a stronger interaction and adsorption on the L surface, while their counterparts on the D surface maintain a supercoiled conformation, indicating a weak interaction (see picture).
Gan
Hui
H
Physikalisches Institut, WWU Münster, Wilhelm-Klemm-Strasse 10, 48149 Müster, Germany.
Tang
Kangjian
K
Sun
Taolei
T
Hirtz
Michael
M
Li
Yong
Y
Chi
Lifeng
L
Butz
Stefan
S
Fuchs
Harald
H
D000327:Adsorption; D003198:Computer Simulation; D003545:Cysteine / Q000031:analogs & derivatives* / Q000737:chemistry; D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D010957:Plasmids / Q000737:chemistry*; D013237:Stereoisomerism; D013499:Surface Properties
C096972:N-isobutyrylcysteine; D006046:Gold; D004247:DNA; D003545:Cysteine