Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.
Since attention has been paid to the use of multiwalled carbon nanotubes (MWCNTs) as biomaterials in contact with bone, it is critical to understand the reaction of bone cells to MWCNTs. We show that MWCNTs inhibit osteoclastic bone resorption in vivo and that MWCNTs inhibit osteoclastic differentiation and suppressed a transcription factor essential for osteoclastogenesis in vitro. These results suggest that MWCNTs have beneficial effects on bones when they are used as biomaterials.
Narita
Nobuyo
N
Department of Orthopedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Nagano, Japan.
Kobayashi
Yasuhiro
Y
Nakamura
Hiroaki
H
Maeda
Kazuhiro
K
Ishihara
Akihiro
A
Mizoguchi
Toshihide
T
Usui
Yuki
Y
Aoki
Kaoru
K
Simizu
Masayuki
M
Kato
Hiroyuki
H
Ozawa
Hidehiro
H
Udagawa
Nobuyuki
N
Endo
Morinobu
M
Takahashi
Naoyuki
N
Saito
Naoto
N
D001672:Biocompatible Materials; D001862:Bone Resorption; D002454:Cell Differentiation; D037742:Nanotubes, Carbon; D010010:Osteoclasts / Q000166:cytology*
D001672:Biocompatible Materials; D037742:Nanotubes, Carbon