title: Phosphine-free palladium-catalyzed allene carbopalladation/allylic alkylation domino sequence: a new route to 4-(alpha-styryl) gamma-lactams.
abstract: Free to decide: Various 4-(alpha-styryl) gamma-lactams are synthesized in 61-88% yield by a phosphine-free palladium-catalyzed carbopalladation/allylic alkylation domino sequence (see scheme). The cyclization is totally regio- and diastereoselective in favor of the 3,4-trans-disubstituted gamma-lactam. The process is successfully applied to the synthesis of a new aza analogue of the naturally occurring lignan (+)-oxo-parabenzlactone.
authors.affiliation: Institut Parisien de Chimie Moléculaire UMR CNRS 7201, UPMC Université Paris 06, 4 Place Jussieu, case 183, 75005, Paris, France.
authors.forename: Claire
authors.initials: C
authors.lastname: Kammerer
authors.forename: Guillaume
authors.initials: G
authors.lastname: Prestat
authors.forename: David
authors.initials: D
authors.lastname: Madec
authors.forename: Giovanni
authors.initials: G
authors.lastname: Poli