title: [Botulinum toxin treatment : therapy success in cases of depression and ongoing pension applications].
abstract: BACKGROUND
  A discrepancy is often observed between the presence of botulinum toxin antibodies (Btx-Ab) and successful therapy. We studied whether depression and an ongoing pension application explain this contradiction.
  
  
  METHODS
  Sixty-five patients treated with Btx were questioned for subjective therapy failure (TF). The extensor digitorum brevis test (EDB test) indicated the presence of Btx-Ab. The Beck Depression Inventory and an exploration investigated for a depressive disturbance as well as an ongoing application for pension. We correlated the EDB test and the TF with a depressive disturbance and the wish for a pension.
  
  
  RESULTS
  Forty-three patients had TF, from which 22 Btx-Ab were positive. A depressive disturbance was found in 25 patients, and an ongoing application for pension in 21. The EDB test and TF did not however correlate TF with a depressive disturbance (P=0.003) and a pension desire (P=0.021). The TF mostly appeared at the beginning of treatment.
  
  
  CONCLUSIONS
  A depressive disturbance and an ongoing application for a pension influence the therapeutic success more strongly initially than the development of Btx-Ab.
  
  
  CONCLUSIONS
  Besides Btx-Ab a depressive disturbance and an ongoing application for pension influences the therapeutic success.
authors.affiliation: Fachabteilung Neurologie, Paracelsus-Klinik , Werdauer Strasse 68, 08060, Zwickau, Deutschland. BachhuberA@web.de
authors.forename: A
authors.initials: A
authors.lastname: Bachhuber
authors.forename: G
authors.initials: G
authors.lastname: Reichel
authors.forename: M
authors.initials: M
authors.lastname: Doberenz
authors.forename: A
authors.initials: A
authors.lastname: Stenner
authors.forename: W
authors.initials: W
authors.lastname: Hermann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001905:Botulinum Toxins / Q000627:therapeutic use*; D003863:Depression / Q000175:diagnosis* / Q000188:drug therapy*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010415:Pensions; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D001905:Botulinum Toxins