Evaluation of self-expandable, FK506-coated, covered stents in canine animal model.
This study aimed to evaluate whether drug coating of the recently developed covered SENDAI stents--self-expandable stents covered with segmented polyurethane (SPU) films--reduces neointimal thickening in animal model. FK506, which is one of the most effective immunosuppressants, was used. Bare stents; non-coated, covered stents; and FK506-coated, covered stents were placed bilaterally in the external iliac arteries of beagle dogs. After 1-month observation period, angiography did not show significant stent-induced stenosis. Histological evaluation revealed a completely endothelialized intravascular lumen and the absence of thrombus formation. The area of the intimal thickening induced by the FK506-coated stents was significantly smaller than that induced by the non-coated stents, whereas it was larger in the case of both the covered stents than that in the case of the bare stent. In conclusion, FK506 treatment of the self-expandable, covered stents was confirmed to effectively inhibit intimal thickening, although the SPU film used for covering functioned as a drug carrier in addition to a scaffold for intimal formation.
Sato
Sachiko
S
Department of Diagnostic Radiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, Japan.
Nakayama
Yasuhide
Y
Matsuhashi
Toshio
T
Seiji
Kazumasa
K
Matsunaga
Kenichi
K
Takasawa
Chiaki
C
Ishibashi
Tadashi
T
Zhou
Yue-Min
YM
Ishibashi-Ueda
Hatsue
H
Okamoto
Yoshihiro
Y
Asano
Hiroyuki
H
Takahashi
Shoki
S
D000792:Angiography / Q000379:methods; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D004337:Drug Carriers; D054855:Drug-Eluting Stents; D005260:Female; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007249:Inflammation; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry*; D016559:Tacrolimus / Q000008:administration & dosage*; D017539:Tunica Intima / Q000473:pathology
D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D007166:Immunosuppressive Agents; D011108:Polymers; D011140:Polyurethanes; D016559:Tacrolimus