[Relationship of 25(OH)VD with bone mass and other indicators in male patients with diabetes mellitus].
OBJECTIVE
To investigate the relationship of serum 25- Hydroxy D with bone mass density and other indicators in male patients with diabetes.


METHODS
Bone mass density (BMD), serum 25- HydroxyD (25 (OH)VD) and several other biochemical indicators were measured in 82 male patients with diabetes, among whom 49 had osteoporosis.


RESULTS
The diabetic patients with osteoporosis had higher tartrate-resistant acid phosphatase-5b (TRCAP-5b) and lower 25(OH)VD, testosterone (T), Dehydroepiandrosterone sulfate (DHEA-S), and bone-specific alkaline phosphatase (B-ALP) than those without osteoporosis (P < 0.05). The Parathormone (PTH) and albumin-creatinine ratio (UAlb/Cr) also increased in the diabetic patients with osteoporosis, but with no statistical significance. No difference was observed in glycosylated hemoglobin (HBA1c) between the diabetic patients with and without osteoporosis. The serum 25(OH)VD was negatively correlated with the duration of diabetes in both groups (P < 0.05), which was independent from the increase of age. The serum 25(OH)VD was positively correlated with T score of neck, ward, greater trochanter of femur and vertebrae lumbales, and T and DHEA-S in both patients with and without osteoporosis (P < 0.05). The 25(OH)VD was also positively correlated with PTH in the patients with osteoporosis. Negative correlation was noted between 25(OH)VD and B-ALP. There were no correlations between 25(OH)VD and TRCAP-5b, HBA1c and UAlb/Cr.


CONCLUSIONS
Serum 25(OH)VD, T and DHEA-S may play an important role in the development of osteoporosis in male patients with diabetes mellitus.
An
Zhen-Mei
ZM
Division of Hormone Assay, Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Huang
Ming-Jie
MJ
Zhang
Mei
M
Xiong
Zhong-Yun
ZY
Guo
Dan
D
D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D000368:Aged; D015519:Bone Density / Q000502:physiology*; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000097:blood / Q000150:complications*; D000071681:Tartrate-Resistant Acid Phosphatase; D013739:Testosterone / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D007527:Isoenzymes; D014807:Vitamin D; D013739:Testosterone; D019314:Dehydroepiandrosterone Sulfate; C104450:25-hydroxyvitamin D; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase