Synergic asymmetric organocatalysis (SAOc) of Cinchona alkaloids and secondary amines in the synthesis of bicyclo[2.2.2]octan-2-ones.
A synergistic effect between chiral secondary and tertiary amines gives access to bicyclo[2.2.2]octan-2-ones with up to 90% ee and >10 : 1 dr.
Bella
Marco
M
Dipartimento di Chimica and Istituto di Chimica Biomolecolare del CNR, Università di Roma "Sapienza", P. le Aldo Moro 5, 00185 Roma, Italy. marco.bella@uniroma1.it
Schietroma
Daniele M Scarpino
DM
Cusella
Pier Paolo
PP
Gasperi
Tecla
T
Visca
Valerio
V