In vitro and in vivo models of acute alcohol exposure.
Alcohol abuse is a global problem due to the financial burden on society and the healthcare system. While the harmful health effects of chronic alcohol abuse are well established, more recent data suggest that acute alcohol consumption also affects human wellbeing. Thus, there is a need for research models in order to fully understand the effect of acute alcohol abuse on different body systems and organs. The present manuscript summarizes the interdisciplinary advantages and disadvantages of currently available human and non-human models of acute alcohol abuse, and identifies their suitability for biomedical research.
Dolganiuc
Angela
A
Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, United States. angela.dolganiuc@umassmed.edu
Szabo
Gyongyi
G
D000428:Alcohol Drinking / Q000503:physiopathology / Q000523:psychology; D000437:Alcoholism / Q000453:epidemiology*; D000818:Animals; D001519:Behavior / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D000431:Ethanol / Q000633:toxicity*; D006801:Humans; D007448:Invertebrates; D008322:Mammals; D008954:Models, Biological; D011323:Primates; D014481:United States; D014714:Vertebrates
D000431:Ethanol