A study of properties of "micelle-enhanced" polyelectrolyte capsules: Structure, encapsulation and in vitro release.
"Micelle-enhanced" polyelectrolyte capsules were fabricated via a layer-by-layer technique, templated on hybrid calcium carbonate particles with built-in polymeric micelles based on polystyrene-b-poly(acrylic acid). Due to the presence of a large number of negatively charged micelles inside the polyelectrolyte capsule, which were liberated from templates, the capsule wall was reconstructed and had properties different to those of conventional polyelectrolyte capsules. This type of capsule could selectively entrap positively charged water-soluble substances. The encapsulation efficiency of positively charged substances was dependent on their molecular weight or size. For some positively charged compounds, such as rhodamine B and lysozyme, the concentration in the capsules was orders of magnitude higher than that in the incubation solution. In addition, in vitro release study suggested that the encapsulated compounds could be released through a sustained manner to a certain degree. All these results point to the fact that these capsules might be used as novel delivery systems for some water-soluble compounds.
Li
Xiaodong
X
Affiliated Stomatology Hospital, Zhejiang University, Hangzhou, China. cisarli@zju.edu.cn
Lu
Tian
T
Zhang
Jianxiang
J
Xu
Jiajie
J
Hu
Qiaoling
Q
Zhao
Shifang
S
Shen
Jiacong
J
D000042:Absorption; D000180:Acrylic Resins / Q000737:chemistry*; D002214:Capsules; D003692:Delayed-Action Preparations / Q000737:chemistry*; D004058:Diffusion; D008422:Materials Testing; D008823:Micelles; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry*
D000180:Acrylic Resins; D002214:Capsules; D003692:Delayed-Action Preparations; D008823:Micelles; D004364:Pharmaceutical Preparations; D011137:Polystyrenes; C006903:carbopol 940