[Expression and regulation of matrix metalloproteases in osteoarthritic cartilage].
The degradation of arthrodial cartilage is a typical characteristic in the pathogenesis of osteoarthritis. matrix metalloproteinases (MMPs) are the primary enzymes involved in extracellular matrix degradation of cartilage. The mechanism of MMPs in extracellular matrix degradation of cartilage is becoming clear with the in-depth study about MMPs, such as activation, activity regulation, related signal transduction pathways and transcription factors. This artice reviewed the activation, expression and regulation of MMPs in the related theory and empirical study of osteoarthritis cartilage.
Dong
Gang
G
The First Clinical Medical College ofZhejiang Chinese Medicine University, Hangzhou 310053, Zhejiang, China.
Zhou
Hui
H
D002356:Cartilage / Q000201:enzymology*; D004789:Enzyme Activation; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D010003:Osteoarthritis / Q000201:enzymology* / Q000235:genetics; D015398:Signal Transduction
D020782:Matrix Metalloproteinases