Antioxidant properties of phytoestrogens.
The oxidation of lipids is an autocatalytic process consisting of a number of well-defined interrelated chemical reactions. Its importance has long been recognized in the food and polymer industry, and recent advances in the understanding of vascular diseases have shown that lipid peroxidation also contributes to human disease. The various chemical stages of the reaction offer several therapeutic targets for inhibition, and from the structural characteristics of phytoestrogens it is anticipated that they should exhibit antioxidant properties. Alone, it is not sufficient for compounds such as the phytoestrogens to exhibit biological activity as antioxidants; the criteria that should be satisfied for this mechanism to be relevant biologically are discussed.
Patel
R P
RP
Center for Free Radical Biology, University of Birmingham at Alabama, Birmingham, AL, USA.
Crawford
J
J
Boersma
B
B
Barnes
S
S
Darley-Usmar
V M
VM