title: Three job stress models/concepts and oxidative DNA damage in a sample of workers in Japan.
abstract: OBJECTIVE
  Three job stress models/concepts (the job demands-control [DC] model, the effort-reward imbalance [ERI] model, and organizational justice) have been linked to coronary heart disease (CHD) at work. In recent years, oxidative DNA damage has been identified as a new risk factor for CHD. However, evidence for the association between these job stressors and oxidative DNA damage is limited. The present cross-sectional study investigated the association between these job stress models/concepts and oxidative DNA damage as a possible mediator of the adverse health effects of job stress.
  
  
  METHODS
  A total of 166 male and 51 female workers of a manufacturing factory in Japan were surveyed using a mailed questionnaire regarding job stressors and demographic, occupational, and lifestyle variables. Urinary concentrations of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative DNA damage, were also measured.
  
  
  RESULTS
  In male subjects, the urinary concentrations of 8-OHdG were significantly higher among the group with lower interactional justice, one of the two components of organizational justice; however, no association was observed with the DC model or the ERI model. In female subjects, high job demands/control ratio was significantly and positively associated with the urinary concentrations of 8-OHdG.
  
  
  CONCLUSIONS
  Interactional justice among male workers and the DC model-based strain among female workers may be associated with increased urinary concentrations of 8-OHdG which possibly reflects oxidative DNA damage.
authors.affiliation: Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. akiomi-tky@umin.ac.jp
authors.forename: Akiomi
authors.initials: A
authors.lastname: Inoue
authors.forename: Norito
authors.initials: N
authors.lastname: Kawakami
authors.forename: Masao
authors.initials: M
authors.lastname: Ishizaki
authors.forename: Masaji
authors.initials: M
authors.lastname: Tabata
authors.forename: Masao
authors.initials: M
authors.lastname: Tsuchiya
authors.forename: Miki
authors.initials: M
authors.lastname: Akiyama
authors.forename: Akiko
authors.initials: A
authors.lastname: Kitazume
authors.forename: Mitsuyo
authors.initials: M
authors.lastname: Kuroda
authors.forename: Akihito
authors.initials: A
authors.lastname: Shimazu
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000652:urine*; D003430:Cross-Sectional Studies; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine; D004651:Employment / Q000523:psychology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006306:Health Surveys; D006801:Humans; D007564:Japan; D008019:Life Style; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012201:Reward; D012737:Sex Factors; D013315:Stress, Psychological / Q000503:physiopathology* / Q000523:psychology*; D016526:Workload / Q000523:psychology*; D017132:Workplace / Q000523:psychology*
chemical_list: D015415:Biomarkers; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine