title: [Not Available].
abstract: Synopsis Antielastase activity of derivatives like 'propionylaminoacid'(C(3) prolin, C(3) hydroxyprolin, C(3) collagen) was examined for pancreatic elastase, and fibroblastic elastase production. Essential metabolic variations of normal dermal fibroblasts were evaluated: adhesion, proliferation capacity, total protein biosynthesis and collagen type I and type III production. Possible other factors such as cellular nutrients were examined by oxygen consumption evaluation. Propionylaminoacid derivatives have antielastase activities. Pancreatic elastase showed dose related inhibition (20% to 50% inhibition for concentration from 5 to 80 mg ml(-1). Moreover, fibroblastic elastase production was inhibited, cellular respiration was enhanced. A very good tolerance in vitro was observed for concentration 0-1 mg ml(-1) range: adhesion, proliferation capacity and collagen (type I and type III) production were not altered, and oxygen consumption was enhanced.
authors.affiliation: Laboratoire de Dermopharmacie et Cosmétologie, Faculté de Pharmacie - 8 avenue Rockefeller - 69008 Lyon.
authors.forename: C
authors.initials: C
authors.lastname: Lafforgue
authors.forename: F
authors.initials: F
authors.lastname: Croute
authors.forename: J F
authors.initials: JF
authors.lastname: Nicolas
authors.forename: D J
authors.initials: DJ
authors.lastname: Hartmann
authors.forename: E
authors.initials: E
authors.lastname: Delaporte
authors.forename: J
authors.initials: J
authors.lastname: Cotte
authors.forename: M C
authors.initials: MC
authors.lastname: Martini