title: Lifestyle factors and serum androgens among 636 middle aged men from seven countries in the European Prospective Investigation into Cancer and Nutrition (EPIC).
abstract: OBJECTIVE
  To evaluate the association between lifestyle and dietary factors and serum concentrations of androgens in middle-aged healthy men.
  
  
  METHODS
  We conducted a cross-sectional analysis of the association of lifestyle factors with circulating concentrations of androstenedione (A-dione), 3-alpha-androstanediol glucuronide (A-diol-g), testosterone (T), SHBG (sex hormone-binding globulin), and free testosterone (FT) among 636 men in the European Prospective Investigation into Cancer and Nutrition.
  
  
  RESULTS
  Compared with the youngest age group (40-49 years), the oldest (70-79 years) had a higher mean concentration of SHBG (by 44%) and lower mean concentrations of A-diol-g (by 29%) FT (19%). Men in the highest BMI group (> or =29.83 kg/m(2)) had a higher mean A-diol-g concentration (by 38%) and lower mean concentration of T (by 20%) SHBG (29%) compared with the lowest (<24.16 kg/m(2)). Current smokers had higher mean concentrations of T (by 13%), SHBG (14%), and A-dione (15%) compared with never smokers. Physical activity and dietary factors were not associated with androgen concentrations, although men in the highest fifth of alcohol intake had higher mean concentrations of A-dione (by 9%), FT (11%) compared with the lowest.
  
  
  CONCLUSIONS
  Our results suggest that age, body weight, smoking, and alcohol intake are associated with circulating androgen concentrations in men.
authors.affiliation: Cancer Epidemiology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK. resuzuki@ncc.go.jp
authors.forename: Reiko
authors.initials: R
authors.lastname: Suzuki
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Paul N
authors.initials: PN
authors.lastname: Appleby
authors.forename: Timothy J
authors.initials: TJ
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authors.forename: Laure
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authors.lastname: Dossus
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authors.forename: Carlotta
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authors.lastname: Sacerdote
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Vittorio
authors.initials: V
authors.lastname: Krogh
authors.forename: Rosario
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authors.lastname: Tumino
authors.forename: Sabine
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authors.lastname: Rohrmann
authors.forename: Jakob
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authors.lastname: Linseisen
authors.forename: Heiner
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authors.lastname: Boeing
authors.forename: Antonia
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authors.lastname: Trichopoulou
authors.forename: Georgios
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authors.lastname: Makrygiannis
authors.forename: Gesthimani
authors.initials: G
authors.lastname: Misirli
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Anne M
authors.initials: AM
authors.lastname: May
authors.forename: María José Tormo
authors.initials: MJ
authors.lastname: Díaz
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Aurelio
authors.initials: A
authors.lastname: Barricarte Gurrea
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodríguez Suárez
authors.forename: Genevieve
authors.initials: G
authors.lastname: Buckland
authors.forename: Nerea
authors.initials: N
authors.lastname: Larrañaga
authors.forename: Sheila
authors.initials: S
authors.lastname: Bingham
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Nadia
authors.initials: N
authors.lastname: Slimani
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
mesh_terms: D000367:Age Factors; D000434:Alcoholic Beverages / Q000009:adverse effects*; D000728:Androgens / Q000097:blood*; D015113:Androstane-3,17-diol / Q000031:analogs & derivatives / Q000097:blood; D000735:Androstenedione / Q000097:blood; D001835:Body Weight; D003430:Cross-Sectional Studies; D005060:Europe / Q000453:epidemiology; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009369:Neoplasms / Q000097:blood / Q000453:epidemiology*; D009752:Nutritional Status; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D012907:Smoking / Q000009:adverse effects*; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood / Q000378:metabolism
chemical_list: D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D015113:Androstane-3,17-diol; C028895:androstane-3,17-diol glucuronide; D013739:Testosterone; D000735:Androstenedione