title: A new mild base-catalyzed Mannich reaction of hetero-arylamines in water: highly efficient stereoselective synthesis of beta-aminoketones under microwave heating.
abstract: A new mild base-catalyzed Mannich reaction of aromatic aldehydes with 1,2-diphenylethanone and hetero-arylamines including pyridin-2-amine and pyrimidin-2-amine is described. In this reaction, a series of new beta-aminoketones were stereoselectively synthesized in water by controlling the steric hindrance of the substrates under microwave heating. This method has the advantages of a short synthetic route, operational simplicity, increased safety for small-scale high-speed synthesis, and minimal environmental impact.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Jiangsu, PR China.
authors.forename: Wen-Juan
authors.initials: WJ
authors.lastname: Hao
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Xu-Dong
authors.initials: XD
authors.lastname: Cao
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Wu
authors.forename: Shu
authors.initials: S
authors.lastname: Yan
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Zhang
authors.forename: Zheng-Guo
authors.initials: ZG
authors.lastname: Han
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000588:Amines / Q000737:chemistry*; D001573:Benzoin / Q000031:analogs & derivatives / Q000737:chemistry; D002384:Catalysis; D006361:Heating; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry; D008352:Mannich Bases / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000588:Amines; D007659:Ketones; D008352:Mannich Bases; D014867:Water; C492807:deoxybenzoin; D001573:Benzoin