title: Verbal cued recall as a predictor of conversion to Alzheimer's disease in Mild Cognitive Impairment.
abstract: OBJECTIVE
  This study was set up to investigate whether neuropsychological tests are able to predict conversion to AD among Mild Cognitive Impairment (MCI) patients.
  
  
  METHODS
  At baseline the cognitive part of the Cambridge Examination for Mental Disorders of the Elderly (CAMCOG), the Mini Mental Status Examination (MMSE), the Geriatric Depression Scale (GDS), a Dutch variation of Rey's Auditory Verbal Learning Test, the Memory Impairment Screen plus (MISplus) and the Visual Association Test (VAT) were administered to 40 patients diagnosed with MCI. After 18 months, MCI-patients were reassessed and a follow-up diagnosis was established. Of those who were seen for follow-up (n = 31), seven fulfilled (NINCDS-ADRDA) criteria of probable AD, while 24 did not convert.
  
  
  RESULTS
  A binary logistic regression analysis showed that the MISplus contributed most to the prediction of conversion (OR = 0.28, 95% CI 0.099-0.790). With a cut-off of 2 out of 6, a positive predictive value of 71.5%, a negative predictive value of 91.5% and an overall diagnostic accuracy of 87.0% were achieved.
  
  
  CONCLUSIONS
  This prospective, longitudinal study shows that a score of 0 or 1 out of 6 on the MISplus may be a good indicator of future (within 18 months) progression to AD among MCI-patients.
authors.affiliation: Developmental and Lifespan Psychology, Vrije Universiteit Brussel, Brussels, Belgium. eva.dierckx@vub.ac.be
authors.forename: E
authors.initials: E
authors.lastname: Dierckx
authors.forename: S
authors.initials: S
authors.lastname: Engelborghs
authors.forename: R
authors.initials: R
authors.lastname: De Raedt
authors.forename: M
authors.initials: M
authors.lastname: Van Buggenhout
authors.forename: P P
authors.initials: PP
authors.lastname: De Deyn
authors.forename: D
authors.initials: D
authors.lastname: Verté
authors.forename: I
authors.initials: I
authors.lastname: Ponjaert-Kristoffersen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000523:psychology; D003072:Cognition Disorders / Q000175:diagnosis* / Q000523:psychology; D003463:Cues; D018450:Disease Progression; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D011939:Mental Recall; D009483:Neuropsychological Tests; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014706:Verbal Learning