An experimental and theoretical investigation into the hydrolysis of dichloro(ethylenediamine)platinum(II) via electrospray mass spectrometry and density functional theory.
Dichloro(ethylenediamine)platinum(II), Pt(en)Cl(2), was dissolved in H(2)O and D(2)O, and the resulting aqueous solutions were electrosprayed into a quadrupole ion-trap mass spectrometer. A series of major and minor ionic hydrolysis products were detected. These ions were then subjected to collision-induced dissociation. As an aid in interpreting the experimental results, density functional theory calculations were carried out. These computations permitted the structures and energetics associated with the hydrolysis products to be determined. An understanding of the hydrolysis of PtenCl(2) and related coordination complexes is essential in the rational design of metal-based drugs.
Yoshikawa
Akihiko
A
Department of Chemistry, The University of Texas at San Antonio, San Antonio, San Antonia, Texas 78249, USA.
Bach
Stephan B H
SB
Merrill
Grant N
GN
D002412:Cations / Q000737:chemistry; D017666:Deuterium Oxide / Q000737:chemistry; D006868:Hydrolysis; D008958:Models, Molecular; D009944:Organoplatinum Compounds / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D002412:Cations; D009944:Organoplatinum Compounds; D014867:Water; C002892:platinum ethylenediamine dichloride; D017666:Deuterium Oxide