title: Successful treatment with intravenous colistin for sinusitis, orbital cellulites, and pneumonia caused by multidrug-resistant metallo-beta-lactamase-producing Pseudomonas aeruginosa in a patient with acute myeloid leukemia.
abstract: The incidence of multidrug-resistant Pseudomonas aeruginosa (MDRPA) and metallo-beta-lactamase (MBL)-producing P. aeruginosa has increased worldwide. The treatment options are limited for infectious diseases caused by these two organisms. The use of colistin has been of recent interest in cases involving both types. We report the case of a 74-year-old man with acute myeloid leukemia who was successfully treated with intravenous colistin for maxillary sinusitis and orbital cellulites due to MBL-producing MDRPA during neutropenia, and then for pneumonia caused by the bacteria after the recovery of neutrophil counts.
authors.affiliation: Department of Clinical Laboratory Medicine, Kyoto University Hospital, Shougoin, Kyoto, Japan. saitota@kuhp.kyoto-u.ac.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
authors.forename: Akifumi
authors.initials: A
authors.lastname: Takaori-Kondo
authors.forename: Masaharu
authors.initials: M
authors.lastname: Tashima
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamashita
authors.forename: Yoshitsugu
authors.initials: Y
authors.lastname: Iinuma
authors.forename: Shunji
authors.initials: S
authors.lastname: Takakura
authors.forename: Miki
authors.initials: M
authors.lastname: Nagao
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ichinohe
authors.forename: Takayuki
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ichiyama
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D003091:Colistin / Q000627:therapeutic use*; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy; D008297:Male; D015523:Maxillary Sinusitis / Q000188:drug therapy / Q000382:microbiology; D054517:Orbital Cellulitis / Q000188:drug therapy / Q000382:microbiology; D011014:Pneumonia / Q000188:drug therapy / Q000382:microbiology; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D011550:Pseudomonas aeruginosa; D016896:Treatment Outcome; D001618:beta-Lactamases
chemical_list: D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; D003091:Colistin