title: Small-cell carcinoma in the common bile duct treated with multidisciplinary management.
abstract: Small-cell carcinoma occasionally occurs in the gastrointestinal tract, with rare reports of it in the biliary system. When it does occur in the biliary system, it is mainly within the gallbladder, and those arising in the extrahepatic bile duct are extremely rare with only seven reported cases to date. A 62-year-old man with this unusual condition is documented. The patient was preoperatively diagnosed as having small-cell carcinoma on the basis of a biopsy specimen and was treated with multidisciplinary management, which consisted of preoperative chemotherapy, a curative resection, adjuvant chemotherapy, and radiation therapy. The patient died 23 months after the initial diagnosis (20 months after surgery). To the best of our knowledge, the survival time of this case was the longest among reported cases, and multidisciplinary management might contribute to a prolonged survival.
authors.affiliation: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center Hospital, 1007 Shimo-Nagakubo, Sunto-Nagaizumi, Shizuoka, 411-8777, Japan. yukiyasu@tj9.so-net.ne.jp
authors.forename: Yukiyasu
authors.initials: Y
authors.lastname: Okamura
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Maeda
authors.forename: Kazuya
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kanemoto
authors.forename: Narikazu
authors.initials: N
authors.lastname: Boku
authors.forename: Hiroyoshi
authors.initials: H
authors.lastname: Furukawa
authors.forename: Keiko
authors.initials: K
authors.lastname: Sasaki
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Uesaka
mesh_terms: D018288:Carcinoma, Small Cell / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D003138:Common Bile Duct Neoplasms / Q000628:therapy*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed