title: [MRI quantification of myocardial function, perfusion, and enhancement in patients with left-ventricular noncompaction].
abstract: OBJECTIVE
  Left ventricular noncompaction is a congenital malformation characterized by a myocardium organized into two layers, one compacted and one noncompacted. We aimed to quantify myocardial function, perfusion, and delayed enhancement using MRI in patients with left-ventricular noncompaction and to compare these results with those of normal patients.
  
  
  METHODS
  We included 12 patients with a myocardial noncompaction / compaction ratio>2.3 at end-diastole in at least one segment apart from the apex and 12 healthy subjects matched for age and sex. We calculated the end-diastolic and end-systolic volumes, stroke volume, ejection fraction, cardiac output, myocardial volume and mass, end-diastolic thickness, and left-ventricular wall thickening and motion. From the delayed enhancement images, we obtained the volume and percentage of hyperenhanced myocardium. Student's t test was used to compare groups.
  
  
  RESULTS
  We observed a statistically significant increase in end-diastolic and end-systolic volumes in patients with left-ventricular noncompaction, as well as decreased ejection fraction, wall motion, and relative maximum upslope in segments 4, 9, and 10. No significant differences were found in delayed hyperenhancement.
  
  
  CONCLUSIONS
  MRI quantification revealed decreased systolic cardiac function and decreased perfusion (lower relative maximum upslope) in the lower segments in patients with noncompaction.
authors.affiliation: Servicio de Radiodiagnóstico, Hospital Universitario Dr Peset, Valencia, Spain. pilarcalvillo@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Calvillo
authors.forename: L
authors.initials: L
authors.lastname: Martí-Bonmatí
authors.forename: F
authors.initials: F
authors.lastname: Chaustre
authors.forename: I
authors.initials: I
authors.lastname: Roldán
authors.forename: V
authors.initials: V
authors.lastname: Mora
authors.forename: A
authors.initials: A
authors.lastname: Peláez
authors.forename: J
authors.initials: J
authors.lastname: Cogollos
authors.forename: J
authors.initials: J
authors.lastname: Ballestín
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D009202:Cardiomyopathies / Q000151:congenital* / Q000175:diagnosis / Q000503:physiopathology*; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult