title: The early and long term function and survival of kidney allografts stored before transplantation by hypothermic pulsatile perfusion. A prospective randomized study.
abstract: BACKGROUND
  A prospective evaluation of the influence of methods of kidney storage prior to transplantation on long-term graft function has not been shown so far. A retrospective study undertaken in 415 patients in our department showed the benefit of machine perfusion (MP) on long-term results. The aim of the present study was to assess prospectively the long term function and survival of paired kidney allografts retrieved from the same donor, comparing the influence of cold storage (CS) and MP.
  
  
  METHODS
  74 recipients included in the study received kidneys from 37 cadaveric donors. Kidneys were randomized to storage by CS or MP. There were no significant differences between the groups as to age, gender, duration of ESRD treatment, PRA titres, HLA compatibility and immunosuppressive regimens.
  
  
  RESULTS
  At 10 years follow-up recipients of CS-stored kidneys returned to dialysis treatment twice as frequently as recipients of MP-stored kidneys (50% vs. 25%, p=0.02).
  
  
  CONCLUSIONS
  Kidney storage by MP improves graft survival and reduces the number of patients who return to dialysis treatment at long-term post-transplant.
authors.affiliation: Department of General and Transplantation Surgery, Warsaw Medical University, Poland.
authors.forename: Artur
authors.initials: A
authors.lastname: Kwiatkowski
authors.forename: Michal
authors.initials: M
authors.lastname: Wszoła
authors.forename: Maciej
authors.initials: M
authors.lastname: Kosieradzki
authors.forename: Roman
authors.initials: R
authors.lastname: Danielewicz
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ostrowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Domagala
authors.forename: Wojciech
authors.initials: W
authors.lastname: Lisik
authors.forename: Slawomir
authors.initials: S
authors.lastname: Fesołowicz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Michalak
authors.forename: Janusz
authors.initials: J
authors.lastname: Trzebicki
authors.forename: Magdalena
authors.initials: M
authors.lastname: Durlik
authors.forename: Leszek
authors.initials: L
authors.lastname: Paczek
authors.forename: Wojciech
authors.initials: W
authors.lastname: Rowiński
authors.forename: Andrzej
authors.initials: A
authors.lastname: Chmura
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D015925:Cryopreservation; D051799:Delayed Graft Function / Q000453:epidemiology*; D005260:Female; D006085:Graft Survival; D006801:Humans; D007035:Hypothermia; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods; D010477:Perfusion; D011446:Prospective Studies; D011673:Pulsatile Flow; D006435:Renal Dialysis; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D055815:Young Adult