title: Two modifications in the treatment of keratocystic odontogenic tumors (KCOT) and the use of Carnoy's solution (CS)--a retrospective study lasting between 2 and 10 years.
abstract: This retrospective study aimed at evaluating the recurrence rates of keratocystic odontogenic tumors (KCOTs) that were enucleated with and without the application of Carnoy's solution (CS). The study included 36 KCOTs treated between 1996 and 2006. Recurrence rates were investigated in correlation with the respective treatment method applied. Additionally, any damage to the inferior alveolar nerve associated with treatment was analyzed. Treatments consisted of enucleation with (38.9%) or without (61.1%) the application of CS. Median follow-up was 4.5 years. Single enucleation showed a recurrence rate of 50%, but the additional application of CS reduced the recurrence rate to 14.3%. No detrimental effects of CS on the mandibular nerve were detected. Enucleation plus the application of CS reduced the recurrence rate of KCOTs compared with simple enucleation. The application of CS did not cause any damage to the mandibular nerve.
authors.affiliation: Department of Cranio-Maxillo-Facial Surgery, University of Regensburg, Franz-Josef-Strauss-Allee 11, Regensburg, Germany. mgosau1@yahoo.de
authors.forename: Martin
authors.initials: M
authors.lastname: Gosau
authors.forename: Florian G
authors.initials: FG
authors.lastname: Draenert
authors.forename: Steffen
authors.initials: S
authors.lastname: Müller
authors.forename: Bernhard
authors.initials: B
authors.lastname: Frerich
authors.forename: Ralf
authors.initials: R
authors.lastname: Bürgers
authors.forename: Thorsten E
authors.initials: TE
authors.lastname: Reichert
authors.forename: Oliver
authors.initials: O
authors.lastname: Driemel
mesh_terms: D019342:Acetic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002425:Cautery / Q000379:methods; D017024:Chemotherapy, Adjuvant / Q000379:methods*; D002648:Child; D002725:Chloroform / Q000494:pharmacology / Q000627:therapeutic use*; D018572:Disease-Free Survival; D000431:Ethanol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000188:drug therapy* / Q000601:surgery; D053208:Kaplan-Meier Estimate; D008297:Male; D008340:Mandibular Nerve / Q000187:drug effects; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D009808:Odontogenic Tumors / Q000188:drug therapy* / Q000601:surgery; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; C033474:Carnoy's solution; D000431:Ethanol; D002725:Chloroform; D019342:Acetic Acid