title: Ziprasidone as an adjuvant for clozapine- or olanzapine-associated medical morbidity in chronic schizophrenia.
abstract: OBJECTIVE
  This study sought to examine the effect of ziprasidone on olanzapine or clozapine-associated medical morbidity such as insulin resistance, diabetes mellitus (DM) and impaired fasting glucose, obesity, and hyperlipidemia in patients with schizophrenia or schizoaffective disorder.
  
  
  METHODS
  This was a 6-week, open label trial of ziprasidone 160 mg/day added to a stable dose of olanzapine or clozapine in 21 schizophrenia or schizoaffective patients with DM, impaired fasting glucose, or insulin resistance.
  
  
  RESULTS
  Ten olanzapine-treated subjects and 11 clozapine-treated subjects were enrolled in the study. There were no significant differences between the two groups at baseline for age, gender, education, ethnicity, BMI, cholesterol levels, or fasting glucose. At week 6, there were no significant changes in weight, BMI, cholesterol levels, or fasting glucose. There was no significant difference in psychotic, negative, or depressive symptoms. QTc significantly increased at week 2 but not at week 6.
  
  
  CONCLUSIONS
  The addition of 160 mg/day of ziprasidone was well tolerated but did not produce significant improvement in fasting glucose, insulin resistance, hyperlipidemia or lead to weight loss in olanzapine- or clozapine-treated subjects with schizophrenia or schizoaffective disorder.
authors.affiliation: Schizophrenia Program, Massachusetts General Hospital, Boston, Massachusetts, USA. dchenderson@partners.org
authors.forename: David C
authors.initials: DC
authors.lastname: Henderson
authors.forename: Xiaoduo
authors.initials: X
authors.lastname: Fan
authors.forename: Paul M
authors.initials: PM
authors.lastname: Copeland
authors.forename: Bikash
authors.initials: B
authors.lastname: Sharma
authors.forename: Christina P
authors.initials: CP
authors.lastname: Borba
authors.forename: Sharon I
authors.initials: SI
authors.lastname: Forstbauer
authors.forename: Kate
authors.initials: K
authors.lastname: Miley
authors.forename: Ryan
authors.initials: R
authors.lastname: Boxill
authors.forename: Oliver
authors.initials: O
authors.lastname: Freudenreich
authors.forename: Corrine
authors.initials: C
authors.lastname: Cather
authors.forename: Anne E
authors.initials: AE
authors.lastname: Evins
authors.forename: Donald C
authors.initials: DC
authors.lastname: Goff
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000187:drug effects; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D002908:Chronic Disease; D003024:Clozapine / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D000077152:Olanzapine; D010879:Piperazines / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy*; D013844:Thiazoles / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D001786:Blood Glucose; D010879:Piperazines; D013844:Thiazoles; D001569:Benzodiazepines; C092292:ziprasidone; D003024:Clozapine; D000077152:Olanzapine