[Alterations of intestinal epithelial barrier and flora in the irritable bowel syndrome].
The irritable bowel syndrome (IBS) is a common bowel disorder that markedly impairs quality of life of patients. The causes of IBS symptoms are not well known. Motility and sensibility disorders, a genetic susceptibility, stress, previous GI infections and food intolerance have been involved in the pathogenesis of IBS. Recent investigations suggest that alterations of the intestinal epithelial barrier integrity, in particular increased permeability, could modify the cross-talk between bacterial microflora and the host, thus leading to persitent "low-grade" inflammation and alterated GI motility and sensitivity.
Piche
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Pôle Digestif, Service de Gastroentérologie et Inserm 895, Hôpital de l'Archet II, Centre Méditerranéen de Médecine Moléculaire, 151 Route Saint Antoine de Ginestière, 06202 Nice cedex 3, France. piche.t@chu-nice.fr
D002463:Cell Membrane Permeability / Q000502:physiology; D017615:Enteric Nervous System / Q000503:physiopathology; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000503:physiopathology*; D007422:Intestines / Q000382:microbiology*; D043183:Irritable Bowel Syndrome / Q000503:physiopathology*