Cisplatin-based chemotherapy for pulmonary metastasized germ cell tumors of the testis--be aware of acute respiratory distress syndrome.
BACKGROUND
Cisplatin-based combination chemotherapy is regarded as standard of care for patients with advanced germ cell tumors. In patients with lung metastases and a high tumor load, an association between induction chemotherapy and the development of a 'tumorassociated' acute respiratory distress syndrome (ARDS) has been hypothesized.


METHODS
We report the clinical course of a 19-year-old patient who rapidly developed fatal ARDS during the first cycle of chemotherapy using the PEI regimen (cisplatin, etoposide and ifosfamide) for a metastasized (lung, liver, lymph nodes) germ cell tumor of the testis.


CONCLUSIONS
Further clinical research in order to better define risk factors for developing ARDS in this patient population as well as novel strategies for the prevention and treatment of ARDS in those patients are necessary.
Boeck
Stefan
S
Department of Internal Medicine III, Klinikum Grosshadern, Ludwig-Maximilians-University of Munich, Germany. stefan.boeck@med.uni-muenchen.de
Metzeler
Klaus H
KH
Hausmann
Andreas
A
Baumann
Anja
A
Gallmeier
Eike
E
Parhofer
Klaus G
KG
Stemmler
Hans-Joachim
HJ
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects*; D005870:Giant Cell Tumors / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000556:secondary*; D008297:Male; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000517:prevention & control; D013736:Testicular Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000556:secondary*; D016896:Treatment Outcome; D055815:Young Adult
D000970:Antineoplastic Agents; D002945:Cisplatin