Urinary GADD45gamma expression is associated with progression of lgA nephropathy.
BACKGROUND
Growth arrest and DNA damage-45gamma (GADD-45gamma) is induced in response to environmental stresses and functions in the regulation of cell cycles. Previous findings by our group suggested that GADD45gamma contributed to renal tubular cell damage through induction of inflammatory and fibrogenic molecules. We examined the effects of urinary GADD45gamma expression on the decline in renal function with IgA nephropathy in the present study.


METHODS
Patients (n = 62) were followed for a total of 710.3 +/- 287.5 days. The rate of renal function decline was assessed by the slopes of inverse serum creatinine and estimated glomerular filtration rate (GFR) plotted against time. Renal survival was calculated by Kaplan-Meier analysis and the primary endpoint was an increase in serum creatinine levels by 50% or more.


RESULTS
Kidney function declined more rapidly in the GADD45gamma-positive group compared to the GADD45gamma-negative group. Kidney survival estimates at the end of the study period were 82.9% in the GADD45gamma-positive group and 100% in the negative group (p = 0.03). This difference remained significant in the group with GFR values <90 ml/min/1.73 m2 when adjusted to stratification factors.


CONCLUSIONS
The results suggest that urinary GADD45gamma expression is associated with progression of renal disease.
Yu
Sukyong
S
Department of Nephrology, Ajou University School of Medicine, Suwon, Korea.
Cho
Jinhee
J
Park
Inwhee
I
Kim
Seung Jung
SJ
Kim
Heungsoo
H
Shin
Gyu-Tae
GT
D000328:Adult; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D005786:Gene Expression Regulation; D005919:Glomerular Filtration Rate; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000652:urine*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000652:urine*; D007668:Kidney / Q000473:pathology*; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D013997:Time Factors; D000097642:GADD45 Proteins
D003404:Creatinine; D047908:Intracellular Signaling Peptides and Proteins; D000097642:GADD45 Proteins