C-arm CT measurement of cerebral blood volume: an experimental study in canines.
OBJECTIVE
Cerebral blood volume (CBV) is an important parameter in estimating the viability of brain tissue following an ischemic event. We tested the hypothesis that C-arm CT measurements of CBV would correlate well with those made with perfusion CT (PCT).


METHODS
CBV was measured in 12 canines by using PCT and C-arm CT. Two measurements with each technique were made on each animal; a different injection protocol was used for each of these techniques. PCT was performed by using a 64-section V-scanner. C-arm CT was performed by using a biplane Artis dBA system. PCT images were transferred to a commercially available workstation for postprocessing and analysis; C-arm CT images were transferred to a commercially available workstation for postprocessing and analysis by using prototype software. From each animal, 2 sections from each technique were selected for analysis.


RESULTS
There was good agreement of both the color maps and absolute numbers between the 2 techniques. The maximum and mean deviations of values between the 2 techniques for the first 5 animals were 30.20% and 7.82%; for the second 7 animals, these values were 26.79% and 7.40%. The maximum and mean deviations between the 2 C-arm CT studies performed on the first 5 animals were 33.15% and 12.24%; for the second 7 animals, these values were 41.15% and 10.89%.


CONCLUSIONS
In these healthy animals, measurement of CBV with C-arm CT compared well with measurements made with PCT.
Ahmed
A S
AS
University of Wisconsin Hospitals and Clinics, Madison, Wis., USA.
Zellerhoff
M
M
Strother
C M
CM
Pulfer
K A
KA
Redel
T
T
Deuerling-Zheng
Y
Y
Royalty
K
K
Consigny
D
D
Niemann
D B
DB
D000818:Animals; D001811:Blood Volume Determination / Q000379:methods*; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D002533:Cerebral Angiography / Q000379:methods*; D004285:Dogs; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*