title: Reaction of carbohydrates with Vilsmeier reagent: a tandem selective chloro O-formylation of sugars.
abstract: A convenient and efficient method for selective replacement of the primary hydroxyl groups of sugars by chlorine with concomitant O-formylation, compatible with the presence of a variety of functional groups, has been developed using the Vilsmeier-Haack reaction. Sugars having free primary hydroxyl groups mostly afforded the chloro-O-formylated product while sugars devoid of primary hydroxyl groups yielded only O-formylated products.
authors.affiliation: Bio-organic Chemistry Division, Indian Institute of Integrative Medicine, Canal Road, Jammu, India-180001.
authors.forename: Niranjan
authors.initials: N
authors.lastname: Thota
authors.forename: Debaraj
authors.initials: D
authors.lastname: Mukherjee
authors.forename: Mallepally Venkat
authors.initials: MV
authors.lastname: Reddy
authors.forename: Syed Khalid
authors.initials: SK
authors.lastname: Yousuf
authors.forename: Surrinder
authors.initials: S
authors.lastname: Koul
authors.forename: Subhash Chandra
authors.initials: SC
authors.lastname: Taneja
mesh_terms: D002236:Carbohydrate Conformation; D002241:Carbohydrates / Q000737:chemistry*; D005561:Formates / Q000138:chemical synthesis* / Q000737:chemistry; D007202:Indicators and Reagents / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002241:Carbohydrates; D005561:Formates; D007202:Indicators and Reagents