title: Cerebrovascular blood flow dynamic changes in fetuses with congenital heart disease.
abstract: OBJECTIVE
  The aim of this study was to determine whether the type of congenital heart disease (CHD) or heart function influence fetal cerebrovascular blood flow dynamics.
  
  
  METHODS
  Doppler flow velocimetry was performed in the umbilical artery (UA) and middle cerebral artery (MCA), and the ratio of the UA pulsatility index (PI) to the MCA PI (U/C PI) was determined in 45 fetuses with CHD at 20-40 weeks' gestational age. The control group consisted of 275 healthy fetuses matched for gestational age. Individual PI measurements were converted into Z-scores for statistical analysis.
  
  
  RESULTS
  Fetuses with CHD (n = 45) had an increased UA PI (p = 0.001) and U/C PI (p < 0.001) when compared to controls. There was no significant difference in the MCA PI between fetuses with CHD (n = 45) and controls (n = 275), while fetuses with CHD complicated by congestive heart failure (CHF) (n = 10) had a decreased MCA PI (p < 0.001) compared to controls.
  
  
  CONCLUSIONS
  The lower PIs observed in the MCA of fetuses with CHD complicated by CHF represents a marker of cerebral vasodilation that is due to cerebral hypoxemia and limiting perfusion. The heart function and type of CHD have an impact on fetal cerebrovascular blood flow distribution and this may contribute to the cause of abnormal neurologic development in these fetuses.
authors.affiliation: Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China. lgr_feus@sina.com
authors.forename: Lv
authors.initials: L
authors.lastname: Guorong
authors.forename: Li
authors.initials: L
authors.lastname: Shaohui
authors.forename: Jin
authors.initials: J
authors.lastname: Peng
authors.forename: Lin
authors.initials: L
authors.lastname: Huitong
authors.forename: Li
authors.initials: L
authors.lastname: Boyi
authors.forename: Xu
authors.initials: X
authors.lastname: Wanhong
authors.forename: Li
authors.initials: L
authors.lastname: Liya
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D004452:Echocardiography; D005260:Female; D005333:Fetus / Q000098:blood supply*; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D011247:Pregnancy; D012039:Regional Blood Flow; D016216:Ultrasonography, Prenatal