Indications for neoadjuvant, adjuvant, and palliative chemotherapy in the treatment of biliary tract cancers.
Advanced biliary tract carcinomas represent a group of aggressive diseases that still carries a poor prognosis. Chemotherapy has been shown to provide disease control and may also prolong survival. An established role for systemic therapy in the adjuvant setting is still lacking. This article reviews the available evidence to support indications of systemic chemotherapy in the palliative setting and discuss the attempts to study it in the perioperative settings.
Huitzil-Melendez
Fidel David
FD
Section of Gastrointestinal Oncology, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10022, USA.
O'Reilly
Eileen M
EM
Duffy
Austin
A
Abou-Alfa
Ghassan K
GK
D001661:Biliary Tract Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D006801:Humans; D020360:Neoadjuvant Therapy; D010166:Palliative Care