Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome.
A 4-month-old baby with a family history of hyper-IgE syndrome acquired Pneumocystis jirovecii pneumonia. The patient's hyper-IgE syndrome score was low, but a genetic study yielded a STAT3 mutation. P. jirovecii pneumonia can be added to the infections associated with hyper-IgE syndrome. In some cases, it may be the presenting manifestation of this immunodeficiency.
Garty
Ben Zion
BZ
Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petah Tiqwa 49202, Israel. gartyb@clalit.org.il
Ben-Baruch
Adit
A
Rolinsky
Asaf
A
Woellner
Cristina
C
Grimbacher
Bodo
B
Marcus
Nufar
N
D000907:Antibodies, Bacterial / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007589:Job Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D008297:Male; D045363:Pneumocystis carinii / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D013902:Radiography, Thoracic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D007073:Immunoglobulin E