Structural requirements of the Pseudomonas quinolone signal for membrane vesicle stimulation.
Pseudomonas aeruginosa produces the quorum signal 2-heptyl-3-hydroxy-4-quinolone (Pseudomonas quinolone signal), which is important for stimulating outer membrane vesicle (MV) formation. Here we describe the importance of the 3-hydroxyl and 2-alkyl chain for MV production and the length of the 2-alkyl chain for association with MVs.
Mashburn-Warren
Lauren
L
Section of Molecular Genetics and Microbiology and Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas 78712, USA.
Howe
Jörg
J
Brandenburg
Klaus
K
Whiteley
Marvin
M
D008070:Lipopolysaccharides / Q000737:chemistry / Q000378:metabolism; D008958:Models, Molecular; D011550:Pseudomonas aeruginosa / Q000378:metabolism*; D015363:Quinolones / Q000737:chemistry* / Q000378:metabolism*; D022142:Secretory Vesicles / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
C407944:2-heptyl-3-hydroxy-4-quinolone; D008070:Lipopolysaccharides; D015363:Quinolones