Occurrence of plantar pustular psoriasis during treatment with infliximab.
BACKGROUND
Pustular psoriasis is an uncommon form of psoriasis that often affects areas of the hands and feet. It typically manifests as small pustules that develop within erythematous areas of the palms and soles. Infliximab, a tumor necrosis factor inhibitor, can be used to treat pustular psoriasis. Infliximab can also be effective in the treatment of various other disorders, including plaque-type psoriasis, psoriatic arthritis, Crohn disease, rheumatoid arthritis, and ankylosing spondylitis.


OBJECTIVE
We present a case of a young woman developing pustular psoriasis for the first time despite being on infliximab treatment for Crohn disease.


RESULTS
Infliximab has been successful in the treatment of pustular psoriasis. In rare cases, plaque psoriasis appears for the first time during infliximab treatment for other disorders, such as Crohn disease.


CONCLUSIONS
Plantar pustular psoriasis occurring for the first time during infliximab treatment is an uncommon occurrence.
English
Penny Lovell
PL
Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON. penny_lovell@yahoo.ca
Vender
Ronald
R
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use*; D003424:Crohn Disease / Q000188:drug therapy*; D004060:Diflucortolone / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D000069285:Infliximab; D011565:Psoriasis / Q000139:chemically induced* / Q000188:drug therapy; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; C013486:diflucortolone valerate; D000069285:Infliximab; D004060:Diflucortolone