title: Tumors that look for their springtime in APRIL.
abstract: Inflammatory cells produce a proliferation inducing ligand (APRIL), one of the most recently cloned members of the tumor necrosis factor (TNF) family. Early experiments implicated APRIL as a promoting factor in the natural course of various cancers, reinforcing the concept that host inflammatory reactions are part of a tumor development. Recent studies have further analyzed the tumor-promoting role of APRIL in patients with solid tumors or with hematological malignancies. Here, we will review the recent literature, and provide evidence that APRIL may be a useful prognostic tool and a potential target in the treatment of some cancers.
authors.affiliation: Division of Hematology, Geneva University Hospitals, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Roosnek
authors.forename: M
authors.initials: M
authors.lastname: Burjanadze
authors.forename: P Y
authors.initials: PY
authors.lastname: Dietrich
authors.forename: T
authors.initials: T
authors.lastname: Matthes
authors.forename: J
authors.initials: J
authors.lastname: Passweg
authors.forename: B
authors.initials: B
authors.lastname: Huard
mesh_terms: D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000502:physiology*
chemical_list: D053300:Tumor Necrosis Factor Ligand Superfamily Member 13