title: A convenient, one-step synthesis of benzyl (Ar) ureas of the type ArCH(2)NHCONHR from Ar and R(1)OCH(2)NHCONHR via ureidoalkylation.
abstract: A method for the one-step C-ureidoalkylation of phenol, anisole, or aniline rings furnishing ArCH(2)NHCONHR (Ar = benzyl) products in moderate to good yields is described. With phenol ring systems, higher yields were attained when the reaction was worked up with an acidic ethanethiol addition to cleave any O-ureidoalkylation products that formed during the reaction.
authors.affiliation: Department of Chemistry, Wichita State University, Wichita, Kansas 67260,
authors.forename: F Alex
authors.initials: FA
authors.lastname: Meece
authors.forename: Champika
authors.initials: C
authors.lastname: Jayasinghe
authors.forename: Gary
authors.initials: G
authors.lastname: Histand
authors.forename: Dennis H
authors.initials: DH
authors.lastname: Burns