title: Repeated occurrence of clozapine-induced myocarditis in a patient with schizoaffective disorder and comorbid Parkinson's disease.
abstract: Myocarditis is a rare but life threatening adverse effect of clozapine. Some symptoms of myocarditis--elevated temperature, tachycardia and fatigue--appear commonly during the onset of treatment with clozapine and during the dose titration. We present a case of a patient with concurrent schizoaffective disorder and Parkinson's disease, who twice developed clozapine-induced myocarditis. All symptoms disappeared after the discontinuation of the drug. Early diagnosis, discontinuation of clozapine and supportive therapy of myocarditis lower the risk of a fatal outcome.
authors.affiliation: Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Hradec Králové, Czech Republic.
authors.forename: Jiri
authors.initials: J
authors.lastname: Masopust
authors.forename: Ales
authors.initials: A
authors.lastname: Urban
authors.forename: Martin
authors.initials: M
authors.lastname: Valis
authors.forename: Radovan
authors.initials: R
authors.lastname: Malý
authors.forename: Ivan
authors.initials: I
authors.lastname: Tůma
authors.forename: Ladislav
authors.initials: L
authors.lastname: Hosák
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000139:chemically induced*; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D010507:Periodicity; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy*; D012008:Recurrence
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine