Intravenous fat emulsion therapy for intentional sustained-release verapamil overdose.
We report the first case of sustained-release verapamil toxicity treated with Intralipid fat emulsion (IFE). Toxicity was confirmed by elevated serial serum verapamil and metabolite, norverapamil, levels. Most previously reported cases of IFE therapy involve local anaesthetic toxicity and cardiac arrest. Our patient was in shock despite standard therapy. No adverse events were noted and the patient fully recovered.
Young
Amy C
AC
Department of Surgery, Division of Emergency Medicine University of Texas Southwestern Medical Center, Emergency Medicine, 5323 Harry Hines Blvd, Dallas, TX 75390-8579, United States. acyoung_2000@yahoo.com
Velez
Larissa I
LI
Kleinschmidt
Kurt C
KC
D000328:Adult; D001919:Bradycardia / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning*; D003692:Delayed-Action Preparations; D062787:Drug Overdose / Q000628:therapy; D004562:Electrocardiography; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D014700:Verapamil / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000506:poisoning*
D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D005217:Fat Emulsions, Intravenous; C016904:norverapamil; D014700:Verapamil