Evaluation of the peroxynitrite scavenging activity of heat-processed ginseng.
To ascertain the principal active peroxynitrite (ONOO(-)) scavenging components of heat-processed Panax ginseng C.A. Meyer (sun ginseng [SG]), the ONOO(-) scavenging activities of fractions and components of SG were compared. The results demonstrated that the ONOO(-) scavenging ability of SG was due to its ether fraction containing phenolic compounds. High-performance liquid chromatography analysis and ONOO(-) scavenging activity tests of the phenolic acids contained in SG identified vanillic acid, ferulic acid, p-coumaric acid, syringic acid, and maltol as the main active ONOO(-) scavenging components of SG. The ONOO(-) scavenging activities of phenolic acids and maltol were dependent on the degrees of their proton donating ability.
Kang
K S
KS
Institute of Natural Medicine, University of Toyama, Toyama, Japan.
Tanaka
T
T
Cho
E J
EJ
Yokozawa
T
T
D003373:Coumaric Acids / Q000302:isolation & purification / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005707:Gallic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D005894:Panax / Q000737:chemistry*; D030421:Peroxynitrous Acid / Q000378:metabolism*; D010636:Phenols / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D011422:Propionates; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology; D014641:Vanillic Acid / Q000302:isolation & purification / Q000494:pharmacology
D003373:Coumaric Acids; D016166:Free Radical Scavengers; D010636:Phenols; D010936:Plant Extracts; D011422:Propionates; D011753:Pyrones; D030421:Peroxynitrous Acid; C008316:maltol; D005707:Gallic Acid; C004999:ferulic acid; C001945:syringic acid; D014641:Vanillic Acid; C495469:p-coumaric acid