title: Vibratory thresholds and mobility in older persons.
abstract: We tested the hypothesis that vibratory thresholds in the elderly are related to mobility. In all, 629 older persons without dementia underwent testing including 11 lower extremity performance measures and modified United Parkinson's Disease Rating Scale (UPDRS), summarized as composite mobility and global parkinsonian signs. Vibratory thresholds were measured at the ankle and toes bilaterally using the graduated Rydel-Seiffer tuning fork. In linear regression models adjusted for age, sex, and education, vibratory threshold was associated with composite mobility (estimate, 0.047, SE = 0.011, P < 0.001) and global parkinsonian signs score (estimate, -0.252, SE = 0.126, P = 0.047). These findings were primarily due to the association of vibratory threshold with gait and balance components of composite mobility and parkinsonian gait. These results were unchanged when we controlled for body mass index, physical activity, cognition, depression, vascular risk factors, vascular disease burden, joint pain, and falls. Vibratory thresholds are associated with mobility, supporting the link between peripheral sensory nerve function and mobility in the elderly.
authors.affiliation: Rush Alzheimer's Disease Center, Armour Academic Facility, Suite #1038; 600 South Paulina, Rush University Medical Center, Chicago, Illinois 60612, USA. Aron_S_Buchman@rush.edu
authors.forename: Aron S
authors.initials: AS
authors.lastname: Buchman
authors.forename: Robert S
authors.initials: RS
authors.lastname: Wilson
authors.forename: Sue
authors.initials: S
authors.lastname: Leurgans
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D020233:Gait Disorders, Neurologic / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007596:Joints / Q000294:innervation / Q000503:physiopathology; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology; D051346:Mobility Limitation; D009069:Movement Disorders / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology*; D018482:Muscle, Skeletal / Q000294:innervation / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis / Q000503:physiopathology; D011237:Predictive Value of Tests; D011434:Proprioception / Q000502:physiology; D012044:Regression Analysis; D012684:Sensory Thresholds / Q000502:physiology*; D017678:Sex Distribution; D020886:Somatosensory Disorders / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology*; D014732:Vibration