title: Characterization of chondroblastic osteosarcoma: gadolinium-enhanced versus diffusion-weighted MR imaging.
abstract: OBJECTIVE
  To detect differences in magnetic resonance imaging (MRI) between chondroblastic osteosarcoma and the other types of osteosarcomas or chondrosarcomas using gadolinium-enhanced versus diffusion-weighted sequences.
  
  
  METHODS
  Contrast-enhanced MRI and diffusion-weighted imaging (DWI) were performed in five chondroblastic osteosarcoma (CO) cases, 17 other types of osteosarcomas (OS), and 18 chondrosarcomas (CS). DWI was obtained with a single-shot echo-planar imaging (EPI) sequence using a 1.5 T MR imager. The apparent diffusion coefficients (ADCs) of the minimum and maximum values were also obtained. The contrast-enhancement pattern was evaluated and minimum-maximum ADC value of CO was compared with other types of OS and CS.
  
  
  RESULTS
  Both CO and CS showed a similar enhancement pattern; both showed septonodular and peripheral rim enhancement. The minimum ADC value of CO (1.24 +/- 0.10 x 10(-3)mm(2)/sec) was significantly higher than that of other types of OS (0.84 +/- 0.15 x 10(-3)mm(2)/sec) and was significantly lower than that of CS (1.64 +/- 0.20 x 10(-3)mm(2)/sec). In addition, the maximum ADC value of CO (2.28 +/- 0.20 x 10(-3)mm(2)/sec) was significantly higher than that of other types of OS (1.33 +/- 0.26 x 10(-3)mm(2)/sec).
  
  
  CONCLUSIONS
  DWI appears to be more useful for differentiating between chondroblastic osteosarcoma and chondrosarcoma or other types of osteosarcoma than Gd-enhanced MRI.
authors.affiliation: Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Kumamoto University, Kumamoto, Japan. t-yakushiji@fc.kuh.kumamoto-u.ac.jp
authors.forename: Toshitake
authors.initials: T
authors.lastname: Yakushiji
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Oka
authors.forename: Hiro
authors.initials: H
authors.lastname: Sato
authors.forename: Shigeta
authors.initials: S
authors.lastname: Yorimitsu
authors.forename: Toru
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizuta
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002648:Child; D002813:Chondrosarcoma / Q000473:pathology*; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging; D005260:Female; D005682:Gadolinium; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology*
chemical_list: D003287:Contrast Media; D005682:Gadolinium