Dynamics of the bacterial SMC complex and SMC-like proteins involved in DNA repair.
Bacteria and archaea possess several different SMC-like proteins, which perform essential functions in a variety of chromosome dynamics, such as chromosome compaction, segregation, and DNA repair. SMC-like proteins localize to distinct sites within the cells at different time points in the cell cycle, or are recruited to sites of DNA breaks and damage. The bacterial SMC (MukB) complex appears to perform a condensin-like function, while SbcC and RecN act early during DNA repair, but apparently at different sites within the cells. Thus, bacterial SMC-like proteins have dynamic functions in chromosome segregation and maintenance of genetic stability.
Graumann
Peter L
PL
Microbiology, Faculty for Biology, University of Freiburg, Schänzle Strasse 1, 79104 Freiburg, Germany. peter.graumann@biologie.uni-freiburg.de
Knust
Tobias
T
D000255:Adenosine Triphosphate / Q000502:physiology; D019843:Archaeal Proteins / Q000737:chemistry / Q000502:physiology; D001412:Bacillus subtilis / Q000166:cytology / Q000235:genetics; D001426:Bacterial Proteins / Q000737:chemistry / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000502:physiology*; D002868:Chromosomal Proteins, Non-Histone / Q000737:chemistry / Q000502:physiology; D020090:Chromosome Segregation / Q000502:physiology; D002876:Chromosomes, Bacterial / Q000502:physiology / Q000648:ultrastructure; D004249:DNA Damage; D004260:DNA Repair / Q000502:physiology*; D004262:DNA Restriction Enzymes / Q000737:chemistry / Q000502:physiology; D004269:DNA, Bacterial / Q000235:genetics; D003851:Deoxyribonucleases / Q000737:chemistry / Q000502:physiology; D004926:Escherichia coli / Q000166:cytology / Q000235:genetics; D029968:Escherichia coli Proteins / Q000737:chemistry / Q000502:physiology; D008957:Models, Genetic; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000502:physiology*; D017434:Protein Structure, Tertiary; D013329:Structure-Activity Relationship
D019843:Archaeal Proteins; D001426:Bacterial Proteins; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; C067035:MukB protein, E coli; D046912:Multiprotein Complexes; C118650:SMC protein, Bacteria; C061563:SbcC protein, Bacteria; D000255:Adenosine Triphosphate; D003851:Deoxyribonucleases; D004262:DNA Restriction Enzymes; C047879:RecN protein, Bacteria