Intramolecular rhodium-catalyzed [2+2+2] cyclizations of diynes with enones.
The Rh(I)-catalyzed inter- and intramolecular [2+2+2] cyclization of diynes with alpha,beta-unsaturated enones proceeds with microwave promotion in good yields. This chemistry was applied to the synthesis of (-)-alcyopterosin I.
Jones
Amanda L
AL
Center for Chemical Methodology and Library Development, and the Department of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, USA.
Snyder
John K
JK
D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D012238:Rhodium / Q000737:chemistry*
D006571:Heterocyclic Compounds; D012238:Rhodium