title: The effect of inhaled nitric oxide on the course of extracorporeal membrane oxygenation and the occurrence of hemorrhagic complications.
abstract: This study evaluated the relation between prior inhaled nitric oxide (iNO) and the time to initiation and duration of treatment with veno-arterial extracorporeal membrane oxygenation (ECMO) and the occurrence of hemorrhagic complications. A retrospective study was conducted in 59 human newborns treated for respiratory insufficiency with ECMO over a 5-year period. Patients received iNO before ECMO (iNO group) or not (control group). Both groups were compared for patient characteristics, postnatal age at the initiation of ECMO, duration of ECMO treatment, and hemorrhagic complications. There were no significant differences between the iNO group and the control group for patient characteristics and medication use before the ECMO treatment, except for norepinephrine. There was no significant difference for postnatal age at the initiation of ECMO and mean duration of ECMO treatment. We found no statistically significant difference in hemorrhagic complications between both groups. This persisted after correction for diagnosis and ECMO run-time in linear logistic regression analysis. Inhaled nitric oxide before ECMO did not result in a significant delay in the initiation of ECMO or longer duration of the ECMO. There was no significant relationship between the use of prior iNO and the occurrence of hemorrhagic complications during the ECMO treatment.
authors.affiliation: Department of Neonatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. a.c.demol@cukz.umcn.nl
authors.forename: Amerik C
authors.initials: AC
authors.lastname: de Mol
authors.forename: Arno F J
authors.initials: AF
authors.lastname: van Heijst
authors.forename: Ton F J
authors.initials: TF
authors.lastname: de Haan
authors.forename: Frans H J M
authors.initials: FH
authors.lastname: van der Staak
authors.forename: Kian D
authors.initials: KD
authors.lastname: Liem
mesh_terms: D000280:Administration, Inhalation; D001993:Bronchodilator Agents / Q000008:administration & dosage*; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology*; D015199:Extracorporeal Membrane Oxygenation / Q000009:adverse effects*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000628:therapy*; D009569:Nitric Oxide / Q000008:administration & dosage*; D012131:Respiratory Insufficiency / Q000628:therapy; D012189:Retrospective Studies
chemical_list: D001993:Bronchodilator Agents; D009569:Nitric Oxide