Characterization of chondroblastic osteosarcoma: gadolinium-enhanced versus diffusion-weighted MR imaging.
OBJECTIVE
To detect differences in magnetic resonance imaging (MRI) between chondroblastic osteosarcoma and the other types of osteosarcomas or chondrosarcomas using gadolinium-enhanced versus diffusion-weighted sequences.


METHODS
Contrast-enhanced MRI and diffusion-weighted imaging (DWI) were performed in five chondroblastic osteosarcoma (CO) cases, 17 other types of osteosarcomas (OS), and 18 chondrosarcomas (CS). DWI was obtained with a single-shot echo-planar imaging (EPI) sequence using a 1.5 T MR imager. The apparent diffusion coefficients (ADCs) of the minimum and maximum values were also obtained. The contrast-enhancement pattern was evaluated and minimum-maximum ADC value of CO was compared with other types of OS and CS.


RESULTS
Both CO and CS showed a similar enhancement pattern; both showed septonodular and peripheral rim enhancement. The minimum ADC value of CO (1.24 +/- 0.10 x 10(-3)mm(2)/sec) was significantly higher than that of other types of OS (0.84 +/- 0.15 x 10(-3)mm(2)/sec) and was significantly lower than that of CS (1.64 +/- 0.20 x 10(-3)mm(2)/sec). In addition, the maximum ADC value of CO (2.28 +/- 0.20 x 10(-3)mm(2)/sec) was significantly higher than that of other types of OS (1.33 +/- 0.26 x 10(-3)mm(2)/sec).


CONCLUSIONS
DWI appears to be more useful for differentiating between chondroblastic osteosarcoma and chondrosarcoma or other types of osteosarcoma than Gd-enhanced MRI.
Yakushiji
Toshitake
T
Department of Orthopaedic and Neuro-Musculoskeletal Surgery, Kumamoto University, Kumamoto, Japan. t-yakushiji@fc.kuh.kumamoto-u.ac.jp
Oka
Kiyoshi
K
Sato
Hiro
H
Yorimitsu
Shigeta
S
Fujimoto
Toru
T
Yamashita
Yasuyuki
Y
Mizuta
Hiroshi
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002648:Child; D002813:Chondrosarcoma / Q000473:pathology*; D003287:Contrast Media; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging; D005260:Female; D005682:Gadolinium; D006801:Humans; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000473:pathology*
D003287:Contrast Media; D005682:Gadolinium