Role of matrix metalloproteinases in skin ageing.
Matrix metalloproteinases are a family of ubiquitous endopeptidases playing a role in many different physiological and pathological processes in the skin. They are also involved in cutaneous ageing. This review summarizes the features and regulation of these enzymes and presents an overview of the molecular mechanisms of both intrinsic and extrinsic skin ageing presents. The role of matrix metalloproteinases in skin ageing is discussed in detail.
Sárdy
Miklós
M
Department of Dermatology and Allergology, Ludwig-Maximilians University, München, Germany.
D004791:Enzyme Inhibitors / Q000494:pharmacology; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007527:Isoenzymes; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species; D015595:Skin Aging / Q000502:physiology*; D014466:Ultraviolet Rays
D004791:Enzyme Inhibitors; D007527:Isoenzymes; D061965:Matrix Metalloproteinase Inhibitors; D017382:Reactive Oxygen Species; D020782:Matrix Metalloproteinases