title: Asthma in humans and cats: is there a common sensitivity to aeroallegens in shared environments?
abstract: Cats spontaneously develop eosinophilic airway inflammation and airway hyperreactivity that is very similar to human allergic asthma. In addition, household cats share environmental exposures to aeroallergens with humans. We review the scientific literature concerning the pathophysiology of feline asthma, including similarities to human asthma and evidence regarding environmental aeroallergen triggers. Results of pathophysiological studies suggest important similarities between human and feline responses to inhaled allergens. Only a few studies were found that examined the development of disease in cats to environmental aeroallergens. Limited evidence suggests that some environmental allergens can cause disease in both cats and humans. It appears that there is a need for greater communication between human and animal health professionals regarding environmental causes of asthma. Specifically, additional research into linkages between human and feline asthma using both molecular techniques and clinical epidemiological approaches could lead to improved understanding of the environmental risks. Finally, there should be consideration of use of naturally affected and/or experimentally induced (using clinically relevant allergens) asthmatic cats in preclinical trials for novel therapeutic interventions.
authors.affiliation: Department of Veterinary Medicine and Surgery, College of Veterinary Medicine, University of Missouri-Columbia, 900 East Campus Drive, Columbia, MO 65211, USA. reineroc@missouri.edu
authors.forename: Carol R
authors.initials: CR
authors.lastname: Reinero
authors.forename: Amy E
authors.initials: AE
authors.lastname: DeClue
authors.forename: Peter
authors.initials: P
authors.lastname: Rabinowitz
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000485:Allergens / Q000633:toxicity*; D000818:Animals; D001249:Asthma / Q000209:etiology* / Q000662:veterinary*; D002371:Cat Diseases / Q000209:etiology*; D002415:Cats; D006801:Humans; D013045:Species Specificity
chemical_list: D000393:Air Pollutants; D000485:Allergens