In Vitro activity of terbinafine combined with caspofungin and azoles against Pythium insidiosum.
In this text we evaluated the in vitro antifungal activities of terbinafine combined with caspofungin, miconazole, ketoconazole, and fluconazole against 17 Pythium insidiosum strains by using the microdilution checkerboard method. Synergistic interactions were observed with terbinafine combined with caspofungin (41.2% of the strains), fluconazole (41.2%), ketoconazole (29.4%), and miconazole (11.8%). No antagonistic effects were observed. The combination of terbinafine plus caspofungin or terbinafine plus fluconazole may have significant therapeutic potential for treatment of pythiosis.
Cavalheiro
Ayrton S
AS
Programa de Pós-Graduação em Farmacologia, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
Maboni
Grazieli
G
de Azevedo
Maria I
MI
Argenta
Juliana S
JS
Pereira
Daniela I B
DI
Spader
Tatiana B
TB
Alves
Sydney H
SH
Santurio
Janio M
JM
D000818:Animals; D000935:Antifungal Agents / Q000145:classification / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D001938:Brazil; D000077336:Caspofungin; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D054714:Echinocandins / Q000494:pharmacology*; D006734:Horse Diseases / Q000382:microbiology; D006736:Horses; D007239:Infections / Q000382:microbiology; D055666:Lipopeptides; D008826:Microbial Sensitivity Tests / Q000379:methods; D009281:Naphthalenes / Q000494:pharmacology*; D011775:Pythium / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D000077291:Terbinafine
D000935:Antifungal Agents; D001393:Azoles; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D000077336:Caspofungin; D000077291:Terbinafine