Functional diversity of dystroglycan.
During the last 15 years, following its identification and first detailed molecular characterization, the dystroglycan (DG) complex has taken centre stage in biology and biomedicine. Functions in different cells and tissues have been identified for this complex, ranging from its typical role in skeletal muscle as a sarcolemmal stabilizer, highlighted by the recently identified "secondary dystroglycanopathies", to a variety of very diverse functions including embryogenesis, cancer progression, virus particle entry and cell signalling. Such functional promiscuity can be in part explained when considering the multiple domain organization of the two DG subunits, the extracellular alpha-DG and the transmembrane beta-DG, that has been largely scrutinized, but only in part unraveled, exploiting a variety of recombinant and transgenic approaches. Herein, while rapidly recapitulating some of the functions that nowadays can be assigned safely to each DG domain, we also try to envisage a sort of worry list featuring and dwelling on some of the most compelling "mysteries" that should be solved to finally understand DG's functional diversity.
Bozzi
Manuela
M
Istituto di Biochimica e Biochimica Clinica, Università Cattolica del Sacro Cuore, Largo F. Vito 1, Rome, Italy.
Morlacchi
Simona
S
Bigotti
Maria Giulia
MG
Sciandra
Francesca
F
Brancaccio
Andrea
A
D000818:Animals; D001485:Basement Membrane / Q000737:chemistry / Q000648:ultrastructure; D015415:Biomarkers; D002467:Cell Nucleus / Q000378:metabolism; D049030:Dystroglycans / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D049028:Dystrophin-Associated Protein Complex / Q000737:chemistry; D047108:Embryonic Development; D019143:Evolution, Molecular; D006801:Humans; D051379:Mice; D009024:Morphogenesis; D009468:Neuromuscular Diseases / Q000235:genetics; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D011991:Receptors, Virus / Q000502:physiology; D012508:Sarcolemma / Q000737:chemistry / Q000648:ultrastructure; D015398:Signal Transduction; D014714:Vertebrates / Q000235:genetics / Q000378:metabolism
D015415:Biomarkers; D049028:Dystrophin-Associated Protein Complex; D021122:Protein Subunits; D011991:Receptors, Virus; D049030:Dystroglycans