title: Influence of water-soluble flavonoids, quercetin-5'-sulfonic acid sodium salt and morin-5'-sulfonic acid sodium salt, on antioxidant parameters in the subacute cadmium intoxication mouse model.
abstract: Water-soluble quercetin-5'-sulfonic acid sodium salt (NaQSA) and morin-5'-sulfonic acid sodium salt (NaMSA) could exert an antagonistic effect on cadmium intoxication. The aim of the study was to examine the influence of these substances on superoxide dismutase (SOD) and glutathione (GSH) levels in the mouse liver in the subacute cadmium intoxication model. NaQSA and NaMSA significantly counteracted cadmium-induced decreases in SOD and GSH levels. No significant differences in SOD and GSH levels between groups exposed to cadmium receiving NaQSA or/and NaMSA were observed.
authors.affiliation: Department of Pharmacology, Wroclaw Medical University, Mikulicza-Radeckiego 2, PL-50-345 Wroclaw, Poland. echlebda@mp.pl
authors.forename: Ewa
authors.initials: E
authors.lastname: Chlebda
authors.forename: Jan
authors.initials: J
authors.lastname: Magdalan
authors.forename: Anna
authors.initials: A
authors.lastname: Merwid-Lad
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Trocha
authors.forename: Maria
authors.initials: M
authors.lastname: Kopacz
authors.forename: Anna
authors.initials: A
authors.lastname: Kuźniar
authors.forename: Dorota
authors.initials: D
authors.lastname: Nowak
authors.forename: Adam
authors.initials: A
authors.lastname: Szelag
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002105:Cadmium Poisoning / Q000188:drug therapy*; D005419:Flavonoids / Q000494:pharmacology*; D005978:Glutathione / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress / Q000187:drug effects; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000187:drug effects; D047309:Flavones
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D005978:Glutathione; D011794:Quercetin; D013482:Superoxide Dismutase; C502510:quercetin-5'-sulfonic acid; C008548:morin; D047309:Flavones