In vivo antimalarial activity of leaves of Plectranthus amboinicus (lour) spreng on Plasmodium berghei yoelii.
An invivo study of aqueous extract of the leaves of Plectranthus amboinicus on Plasmodium berghei yoelii was conducted on laboratory infected albino mice and compared with standard drug chloroquine. Reduction of parasitemia at 250 mg/kg and 500 mg/kg of aqueous extract for 24 hrs, 48 hrs, 72 hrs and 96 hrs were determined. The reduction of parasitemia after 96 hrs was 100%, 67.9% and 76.2% for standard, 250 mg/kg and 500 mg/kg of aqueous extract respectively. The isolation of active principle responsible for the reduction of parasitemia may give a promising drug molecule.
Periyanayagam
K
K
Department of Pharmacognosy, Madurai Medical College, Madurai, 625020, Tamil Nadu, India. kpn1960@yahoo.com
Nirmala Devi
K
K
Suseela
L
L
Uma
A
A
Ismail
M
M
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology / Q000627:therapeutic use*; D002738:Chloroquine / Q000494:pharmacology / Q000627:therapeutic use*; D031330:Coleus / Q000737:chemistry; D005260:Female; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D051379:Mice; D018512:Parasitemia / Q000188:drug therapy* / Q000469:parasitology; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D010967:Plasmodium yoelii / Q000187:drug effects*; D031346:Plectranthus / Q000737:chemistry*; D016896:Treatment Outcome
D000962:Antimalarials; D010936:Plant Extracts; D002738:Chloroquine