Ceftriaxone-induced acute reversible encephalopathy in a patient treated for a urinary tract infection.
Encephalopathy is a rare side effect of third- and fourth-generation cephalosporins. Renal failure and previous disease of the central nervous system predispose to this neurotoxicity. We describe a case of encephalopathy with generalised triphasic waves in a patient with pre-existent cerebrovascular disease who was treated with ceftriaxone for a urinary tract infection. Early recognition of this complication is relevant given that ceftriaxone discontinuation reverted the neurological syndrome.
Roncon-Albuquerque
R
R
Department of Internal Medicine, Faculty of Medicine of Porto, Hospital S. João, Porto, Portugal. rra_jr@yahoo.com
Pires
I
I
Martins
R
R
Real
R
R
Sousa
G
G
von Hafe
P
P
D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D002443:Ceftriaxone / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D020258:Neurotoxicity Syndromes; D012307:Risk Factors; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D002443:Ceftriaxone