title: Use of self-expandable metal stents for the treatment of esophageal perforations and anastomotic leaks.
abstract: BACKGROUND
  Esophageal perforations and extensive anastomotic leaks after esophageal resection or gastrectomy are surgical emergencies with high mortality rates. In recent years, the use of self-expanding metallic stents (SEMS) has emerged as a promising treatment alternative for bridging and sealing the damage. This study aimed to evaluate the role of covered SEMS for the management of esophageal perforations and anastomotic leaks.
  
  
  METHODS
  All esophageal stent placement procedures (174 procedures for 157 patients) at the authors' unit between January 1999 and April 2008 were assessed by a retrospective chart review. Of the 157 patients, 10 (6.4%) were treated with SEMS for sealing of an iatrogenic esophageal perforation (n = 4), a spontaneous esophageal rupture in Boerhaave's syndrome (n = 4), or an anastomotic leakage (n = 2).
  
  
  RESULTS
  The median time from perforation or anastomotic leak to stent insertion was 13 days (range, 2 h to 48 days). The esophageal leak was totally sealed for 8 (80%) of 10 patients. The overall mortality rate was 50% (n = 5), and three (30%) of the five deaths were related to the perforation (n = 2) or leakage (n = 1). In both of the perforation cases, the diagnosis and treatment were substantially delayed. One patient with an anastomotic leak after gastrectomy died of the complication despite successful operative and SEMS treatment. Two of the deaths were unrelated to the perforation. In both cases, the cause of death was a disseminated malignant disease.
  
  
  CONCLUSIONS
  Traumatic perforations and anastomotic leaks can be treated effectively with covered SEMS together with adequate drainage of the thoracic cavity even in cases of severely ill patients with inveterate esophageal perforations and leaks.
authors.affiliation: Department of Surgery, Turku University Central Hospital, Turku, Finland. paulina.salminen@tyks.fi
authors.forename: P
authors.initials: P
authors.lastname: Salminen
authors.forename: R
authors.initials: R
authors.lastname: Gullichsen
authors.forename: S
authors.initials: S
authors.lastname: Laine
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical / Q000009:adverse effects; D003131:Combined Modality Therapy; D004322:Drainage; D004867:Equipment Design; D004935:Esophageal Diseases / Q000601:surgery; D004939:Esophageal Perforation / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D004945:Esophagoscopy; D004947:Esophagus / Q000293:injuries / Q000601:surgery; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000401:mortality / Q000601:surgery; D010288:Parenteral Nutrition; D011183:Postoperative Complications / Q000601:surgery*; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D012422:Rupture, Spontaneous / Q000601:surgery; D015607:Stents; D013577:Syndrome