Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients.
BACKGROUND
The co-morbidity of cystic fibrosis (CF) and celiac disease (CD) has been reported sporadically since the 1960s. To our knowledge, this is the first time a systematic screening is performed in a large cohort of CF patients.


METHODS
Transglutaminase-IgA (TGA), endomysium-IgA (EMA) and total IgA in serum were measured in 790 CF patients (48% females, 86% with pancreatic insufficiency). Six patients were diagnosed with CD prior to the study, all receiving a gluten-free diet. Patients with elevated TGA (>50 Units/mL) and a positive EMA test were offered a gastroscopy obtaining mucosal biopsies from the duodenum.


RESULTS
Four new cases of CD were diagnosed. Two additional patients had positive serological tests, but normal biopsies. In total, 10 cases of CD (1.2%, 1:83) indicate a prevalence rate about three times higher than the general prevalence of CD in Norway and Sweden. No CD patients were detected in the Danish CF cohort. Patients diagnosed with untreated CD reported symptoms typical of both CF and CD (poor weight gain, loose and/or fatty stools, fatigue, irritability, abdominal pain). They improved after introduction of a gluten-free diet.


CONCLUSIONS
Systematic screening for CD in a Scandinavian cohort of CF patients revealed a higher prevalence of CD than in the general population. Clinical signs of CD are difficult to differentiate from CF with malabsorption, and patients may go undiagnosed for a long time. In a population where CD is common we recommend screening for CD in patients with CF.
Fluge
G
G
Department of Pediatrics, Haukeland Univ. Hospital, Bergen, Norway. gjermund.fluge@pedi.uib.no
Olesen
H V
HV
Gilljam
M
M
Meyer
P
P
Pressler
T
T
Storrösten
O T
OT
Karpati
F
F
Hjelte
L
L
D000293:Adolescent; D000328:Adult; D002446:Celiac Disease / Q000097:blood / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007223:Infant; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012537:Scandinavian and Nordic Countries / Q000453:epidemiology; D055815:Young Adult
D007070:Immunoglobulin A