title: Antiepileptogenic effects of glutathione against increased brain ADA in PTZ-induced epilepsy.
abstract: Adenosine has been shown to play a significant role as a modulator of neuronal activity in convulsive disorders, acting as an endogenous anticonvulsant agent. Any change in adenosine deaminase (ADA) levels will reflect to adenosine levels. In the present study, we have investigated the effect of glutathione on brain tissue ADA levels due to seizures induced by convulsive and subconvulsive dose of pentylenetetrazol (PTZ) in mice. ADA levels due to seizures induced by convulsive and subconvulsive pentylenetetrazol were measured using the Giusti method. ADA levels were higher in the experimental epilepsy groups than in the control and sham groups. ADA levels significantly decreased in the glutathione groups, which may have antiseizure effects. Decreased levels of ADA would be due to increased adenosine levels, protecting against oxidative stress.
authors.affiliation: Department of Physiology, Faculty of Medicine, University of Gaziantep, Gaziantep, Turkey. pence@gantep.edu.tr
authors.forename: Sadrettin
authors.initials: S
authors.lastname: Pence
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Erkutlu
authors.forename: Naciye
authors.initials: N
authors.lastname: Kurtul
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bosnak
authors.forename: Mehmet
authors.initials: M
authors.lastname: Alptekin
authors.forename: Uner
authors.initials: U
authors.lastname: Tan
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D003292:Convulsants; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D005978:Glutathione / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D011897:Random Allocation
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D000243:Adenosine Deaminase; D005978:Glutathione; D010433:Pentylenetetrazole