title: CSF levels of cytokines in neuro-Behçet's disease.
abstract: BACKGROUND
  Neurological manifestations of Behçet's disease (neuro-Behçet's disease) present in 5-30% of patients. Although cytokines play a pivotal role in pathogenesis of Behçet's disease, published studies about the cerebrospinal fluid (CSF) levels of cytokines in neuro-Behçet's disease are scanty.
  
  
  METHODS
  Nine patients with active parenchymal, one patient with non-parenchymal neuro-Behçet's disease, six patients with headache attributed to Behçet's disease, 13 patients with viral meningitis, and 19 healthy controls were recruited. Interleukin 6, 8, 10, tumor necrotic factor-alpha, and interferon-gamma were measured in the CSF using enzyme-linked immunosorbent assay method.
  
  
  RESULTS
  Patients with viral meningitis had significantly higher levels of all investigated cytokines except for interferon-gamma in comparison with the patients with parenchymal neuro-Behçet's disease, headache attributed to Behçet's disease and controls (P values <0.05). CSF interleukin 6 was significantly higher in patients with parenchymal neuro-Behçet's disease in comparison with the controls (P=0.025). CSF levels of investigated cytokines had no significant difference between patients with headache attributed to Behçet's disease and controls (P values >0.05). Patients with headache attributed to BD and patients with parenchymal NBD had no significant difference in measured cytokines (P values >0.05).
  
  
  CONCLUSIONS
  In contrast to some previous studies, our investigation showed loss of analogy between CSF cytokine profiles of patients with parenchymal neuro-Behçet's disease and viral meningitis. Also we postulated a crucial role for interleukin 6 in immunopathogenesis of neuro-Behçet's disease.
authors.affiliation: Department of Neurology, Shiraz University of Medical Sciences, Shiraz 71345, Iran. borhanihaghighi@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Borhani Haghighi
authors.forename: H
authors.initials: H
authors.lastname: Ittehadi
authors.forename: A R
authors.initials: AR
authors.lastname: Nikseresht
authors.forename: J
authors.initials: J
authors.lastname: Rahmati
authors.forename: S Ghaffari
authors.initials: SG
authors.lastname: Poorjahromi
authors.forename: B
authors.initials: B
authors.lastname: Pourabbas
authors.forename: M A
authors.initials: MA
authors.lastname: Nazarinia
authors.forename: Z
authors.initials: Z
authors.lastname: Habibagahi
authors.forename: M J
authors.initials: MJ
authors.lastname: Fattahi
authors.forename: A
authors.initials: A
authors.lastname: Ghaderi
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000134:cerebrospinal fluid* / Q000145:classification / Q000150:complications; D016022:Case-Control Studies; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000145:classification / Q000209:etiology; D016207:Cytokines / Q000134:cerebrospinal fluid*; D005260:Female; D006261:Headache / Q000134:cerebrospinal fluid / Q000209:etiology; D006801:Humans; D007371:Interferon-gamma / Q000134:cerebrospinal fluid; D016753:Interleukin-10 / Q000134:cerebrospinal fluid; D015850:Interleukin-6 / Q000134:cerebrospinal fluid; D016209:Interleukin-8 / Q000134:cerebrospinal fluid; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid*; D012016:Reference Values; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid; D055815:Young Adult
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma