Antifungal combinations against simulated Candida albicans endocardial vegetations.
The in vitro effects of flucytosine (5FC), liposomal amphotericin B (L-AmB), and micafungin (Mica) combinations against two Candida albicans strains that simulated 24-hour-old endocardial vegetations were studied. Mica was superior to 5FC or L-AmB, and the 5FC-L-AmB-Mica combination was superior to all other treatments for one strain but no different from the dual combination of L-AmB-Mica for the other strain.
Pai
Manjunath P
MP
College of Pharmacy, University of New Mexico, Albuquerque, New Mexico, USA. apai-icpd@OrdwayResearch.org
D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D018441:Biofilms / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects*; D004338:Drug Combinations; D054714:Echinocandins / Q000008:administration & dosage*; D004696:Endocarditis / Q000188:drug therapy*; D005437:Flucytosine / Q000008:administration & dosage*; D006801:Humans; D055666:Lipopeptides / Q000008:administration & dosage*; D000077551:Micafungin
D000935:Antifungal Agents; D004338:Drug Combinations; D054714:Echinocandins; D055666:Lipopeptides; C068538:liposomal amphotericin B; D000666:Amphotericin B; D005437:Flucytosine; D000077551:Micafungin