The impact of dietary organic and transgenic soy on the reproductive system of female adult rat.
The goal of this article was to compare the effects of a prolonged use of organic and transgenic soy on the lipid profile and ovary and uterus morphology. Wistar rats were fed three different diets from weaning until sacrifice at 15 months of age. The three diets were: casein-based diet control group (CG), organic soy-based diet group (OSG), or transgenic soy-based diet group (GMSG). There were no differences in food consumption or in the diet isoflavone components among the groups. Compared with the CG diet, both the OSG and GMSG diets were associated with significant reductions in body weight, serum triglycerides, and cholesterol (P < 0.05) (CG = 406 +/- 23.1; 104.3 +/- 13.2; 119.9 +/- 7.3 GMSG = 368 +/- 17.6; 60.3 +/- 4.6; 83.3 +/- 5.7 OSG = 389 +/- 23.5; 72.3 +/- 12.5; 95.5 +/- 8.0, respectively). The volume density of endometrial glandular epithelium was greater in the GMSG group (29.5 +/- 7.17, P < 0.001) when compared with the CG (18.5 +/- 7.4) and OSG (20.3 +/- 10.6) groups. The length density of endometrial glandular epithelium was shorter in both GMSG (567.6 +/- 41.1) and OSG (514.8 +/- 144.5) diets compared with the CG (P < 0.05) diet. GMSG also resulted in reduced follicle number and increased corpus luteum number compared to the OSG or CG diets (P < 0.05). In summary, both GMSG and OSG diets resulted in decreased body weight and lower serum triglyceride and cholesterol levels, and alterations in uterine and ovarian morphology were also observed. The prolonged use of soy-based diets and their relation to reproductive health warrants further investigation.
Brasil
Flávia Bittencourt
FB
Urogenital Research Unit, State University of Rio de Janeiro, Rio de Janeiro, Brazil.
Soares
Lavínia Leal
LL
Faria
Tatiane Silva
TS
Boaventura
Gilson Telles
GT
Sampaio
Francisco José Barcellos
FJ
Ramos
Cristiane Fonte
CF
D000818:Animals; D030801:Animals, Genetically Modified; D001835:Body Weight / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004044:Dietary Proteins / Q000378:metabolism / Q000494:pharmacology; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005526:Food, Formulated; D007529:Isoflavones / Q000378:metabolism / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects / Q000502:physiology; D008055:Lipids / Q000097:blood*; D009747:Nutritional Physiological Phenomena; D009929:Organ Size / Q000187:drug effects / Q000502:physiology; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism*; D010940:Plant Proteins / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D045730:Soy Foods; D014280:Triglycerides / Q000097:blood; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism*; D015431:Weight Loss / Q000187:drug effects / Q000502:physiology
D004044:Dietary Proteins; D007529:Isoflavones; D008055:Lipids; D010940:Plant Proteins; D014280:Triglycerides; D002784:Cholesterol