Effect of Fas -670 A/G gene polymorphism on corneal allograft endothelial rejection.
Human cornea expresses functional Fas-ligand capable of killing Fas+ activated lymphocytes. Fas expression is partly regulated by -670 A/G polymorphism in the promoter region of Fas gene.



The aim of the present study is to determine the association between Fas-670A/G polymorphism and survival of corneal transplantation.



In 276 graft recipients who mainly underwent penetrating keratoplasty because of keratoconus, bullous keratopathy and corneal opacity, Fas -670 A/G polymorphism was determined by allele specific oligonucleotide polymerase chain reaction (ASO-PCR) techniques.



There was no statistically significant relationship between Fas -670 A/G polymorphism and rejection episode (p=0.35). Moreover, the relationship between this polymorphism and rejection episode outcome (transplant recovery vs failure) was not statistically significant (p=0.13).



The results of the present study show no significant correlation between corneal graft rejection, rejection recovery and Fas -670A/G gene polymorphism.
Jahadi Hosseini
Hamid Reza
HR
Department of Ophthalmology, Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. jahadih@sums.ac.ir
Kamali Sarvestani
Eskandar
E
Akbari
Mitra
M
Mosallaei
Mahnaz
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D016039:Corneal Transplantation; D003430:Cross-Sectional Studies; D004728:Endothelium, Corneal / Q000276:immunology*; D005128:Eye Diseases / Q000628:therapy; D005260:Female; D005787:Gene Frequency / Q000276:immunology; D006084:Graft Rejection / Q000235:genetics* / Q000276:immunology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015948:Keratoplasty, Penetrating; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics / Q000276:immunology*; D055815:Young Adult; D019014:fas Receptor / Q000235:genetics* / Q000276:immunology*
C491901:FAS protein, human; D019014:fas Receptor