title: [Congenital tuberculosis in preterm neonate: a case report].
abstract: Congenital tuberculosis is a rare but severe disease. Diagnosis is often delayed, especially in preterm neonates. We report a premature infant born after 27 weeks of gestation and in vitro fertilization. Tuberculosis was suspected after 112 days of life in view of sepsis, respiratory distress, and the discovery of maternal tuberculosis. Mycobacterium tuberculosis was isolated in endotracheal aspirates, gastric aspirates, and stools. The infant initially received four antitubercular antibiotics over 3 months, then two antibiotics over 9 months. A wide screening for a possible nosocomial transmission from this index case was set up. At the chronological age of 2 years, the baby is healthy without after-effects and no secondary cases were diagnosed. This article recalls the difficulty diagnosing congenital tuberculosis, particularly in preterm neonates. It also underlines the need to raise and eliminate the diagnosis of tuberculosis in an infertile woman.
authors.affiliation: Service de réanimation pédiatrique et néonatale, unité de brûlés pédiatriques, département d'anesthésie-réanimation, pôle RAUC, CHU Nord, chemin des Bourrely, 13915 Marseille cedex 20, France.
authors.forename: C
authors.initials: C
authors.lastname: Bonnet
authors.forename: F
authors.initials: F
authors.lastname: Michel
authors.forename: C
authors.initials: C
authors.lastname: Nicaise
authors.forename: K
authors.initials: K
authors.lastname: Chaumoître
authors.forename: S
authors.initials: S
authors.lastname: Hassid
authors.forename: M
authors.initials: M
authors.lastname: Uters
authors.forename: L
authors.initials: L
authors.lastname: Thomachot
authors.forename: R
authors.initials: R
authors.lastname: Vialet
authors.forename: K
authors.initials: K
authors.lastname: Retornaz
authors.forename: P
authors.initials: P
authors.lastname: Lagier
authors.forename: C
authors.initials: C
authors.lastname: Martin
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005243:Feces / Q000382:microbiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D016896:Treatment Outcome; D014376:Tuberculosis / Q000151:congenital* / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents