title: Allosteric switches: remote controls for proteins.
abstract: Long-distance service: Finding a selective small-molecule modulator for every domain of every human protein is a Herculean task. Wouldn't it be much easier to control the activity of any protein of choice by simply fusing it with a generally adaptable switch protein and controlling protein activity indirectly?
authors.affiliation: Department of Molecular Biology, Max Planck Institute of Biochemistry and Cluster for Integrated Protein Science Munich, Am Klopferspitz 18, 82152 Martinsried, Germany. berg@biochem.mpg.de
authors.forename: Thorsten
authors.initials: T
authors.lastname: Berg
mesh_terms: D000494:Allosteric Regulation; D006801:Humans; D011487:Protein Conformation; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D011993:Recombinant Fusion Proteins