A new USP Class VI-compliant substrate for manufacturing disposable microfluidic devices.
As microfluidic systems transition from research tools to disposable clinical-diagnostic devices, new substrate materials are needed to meet both the regulatory requirement as well as the economics of disposable devices. This paper introduces a UV-curable polyurethane-methacrylate (PUMA) substrate that has been qualified for medical use and meets all of the challenges of manufacturing microfluidic devices. PUMA is optically transparent, biocompatible, and exhibits high electroosmotic mobility without surface modification. We report two production processes that are compatible with the existing methods of rapid prototyping and present characterizations of the resultant PUMA microfluidic devices.
Kuo
Jason S
JS
Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
Ng
Laiying
L
Yen
Gloria S
GS
Lorenz
Robert M
RM
Schiro
Perry G
PG
Edgar
J Scott
JS
Zhao
Yongxi
Y
Lim
David S W
DS
Allen
Peter B
PB
Jeffries
Gavin D M
GD
Chiu
Daniel T
DT
D001672:Biocompatible Materials / Q000737:chemistry; D003132:Commerce / Q000295:instrumentation*; D004867:Equipment Design / Q000295:instrumentation*; D008689:Methacrylates / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D044085:Microfluidics / Q000295:instrumentation*; D008855:Microscopy, Electron, Scanning; D010602:Pharmacopoeias as Topic / Q000592:standards*; D011140:Polyurethanes / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013379:Substrate Specificity; D013499:Surface Properties; D014481:United States
D001672:Biocompatible Materials; D008689:Methacrylates; D011140:Polyurethanes