title: [Effect of a traditional Chinese medicine compound on chronic heart failure in guinea-pigs].
abstract: OBJECTIVE
  To investigate the effect of a traditional Chinese medicine compound (CTMC) on chronic heart failure (CHF) in guinea-pigs.
  
  
  METHODS
  The CHF of guinea-pigs were induced by repeated injection of hyodemic isoproterenol. The hemodynamics, organ (heart, lung, liver and kidney)/body weight ratio, pathological changes, and serum cTn-I and CK-MB were measured to determine the effectiveness of the traditional Chinese medicine treatement.
  
  
  RESULTS
  The LVDP and LVEDP were decreased and the absolute value of + dp/dt(max) and - dp/ dt(max) were increased by the administration of 10 mg/kg, 20 mg/kg and 30 mg/kg of the compound tablets. The effect increased with doses. The traditional Chinese medicine also decreased the area of myocardial necrosis and the degree of injury to myocardiacyte. The intervention group had lower serum cTn-I and CK-MB levels than the controls.
  
  
  CONCLUSIONS
  The compound tablets can improve the left ventricular diastolic function of CHF and reduce the myocardial damage in a dose-dependent manner.
authors.affiliation: Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Disease of Ministry of Health, Xi'an Jiaotong University, Xi'an 710061, China.
authors.forename: Wu-Hong
authors.initials: WH
authors.lastname: Tan
authors.forename: Xiao-Yang
authors.initials: XY
authors.lastname: Du
authors.forename: Jian
authors.initials: J
authors.lastname: Liu
authors.forename: Lian-Bang
authors.initials: LB
authors.lastname: Zhai
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Wang
authors.forename: Dong
authors.initials: D
authors.lastname: Geng
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal