title: Increased mean platelet volume in rheumatic mitral stenosis: a possible factor for thromboembolic events.
abstract: BACKGROUND
  Systemic embolism is an important complication in patients with rheumatic mitral stenosis (RMS). The mean platelet volume (MPV) is considered a marker and determinant of platelet function since larger platelets are hemostatically more reactive than platelets of normal size, increasing the propensity to thrombosis. The aim of this study was to investigate MPV in patients with RMS and healthy control subjects.
  
  
  METHODS
  We selected 30 consecutive patients with RMS and 31 consecutive healthy age- and sex-matched control subjects. All subjects were in sinus rhythm. We measured MPV in a blood sample collected in EDTA.
  
  
  RESULTS
  Demographic data of the RMS (mean age: 39.5+/-9.9 years, 22 [71%] female) and control groups (mean age: 39.2+/-9.3 years, 20 [67%] female) were similar. The MPV was significantly higher in patients with RMS 8.8 (8.2-11.3) fl than control subjects 8.1 (7.1-9.3) (P<0.001).
  
  
  CONCLUSIONS
  Elevated MPV might be considered as a marker of increased thromboembolic risk in patients with RMS. We suggest that patients with high MPV values might benefit from antiplatelet therapy.
authors.affiliation: Kecioren Teaching and Research Hospital, Department of Cardiology, Ankara, Turkey. byavuzmd@gmail.com
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Yavuz
authors.forename: Derun Taner
authors.initials: DT
authors.lastname: Ertugrul
authors.forename: Ahmet Arif
authors.initials: AA
authors.lastname: Yalcin
authors.forename: Metin
authors.initials: M
authors.lastname: Kucukazman
authors.forename: Naim
authors.initials: N
authors.lastname: Ata
authors.forename: Kursad
authors.initials: K
authors.lastname: Dal
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000166:cytology*; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D008946:Mitral Valve Stenosis / Q000097:blood* / Q000150:complications*; D012214:Rheumatic Heart Disease / Q000097:blood* / Q000150:complications*; D013923:Thromboembolism / Q000209:etiology*