Pd(II)-catalyzed olefination of electron-deficient arenes using 2,6-dialkylpyridine ligands.
Pd(II)-catalyzed meta-olefination of highly electron-deficient arenes is achieved through the use of a rationally designed mutually repulsive ligand. The combination of directed and nondirected C-H functionalization of arenes provides a versatile route for the synthesis of highly sought after 1,2,4-trisubstituted arenes.
Zhang
Yang-Hui
YH
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Shi
Bing-Feng
BF
Yu
Jin-Quan
JQ
D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D004583:Electrons; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D008024:Ligands; D010165:Palladium / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*
D000475:Alkenes; D006841:Hydrocarbons, Aromatic; D008024:Ligands; D011725:Pyridines; D010165:Palladium