Borna disease virus: a unique pathogen and its interaction with intracellular signalling pathways.
Borna disease virus (BDV) is a neurotropic RNA virus that establishes non-cytolytic persistent infection in the central nervous system of warm-blooded animals. Depending on the host species and the route of infection, BDV persistence can modulate neuronal plasticity and animal behaviour and/or may provoke a T cell-mediated immunopathological reaction with high mortality. Therefore, BDV functions as a model pathogen to study persistent virus infection in the central nervous system. Here, we review recent evidence showing that BDV interferes with a spectrum of intracellular signalling pathways, which may be involved in viral spread, maintenance of persistence and modulation of neurotransmitter pathways.
Planz
Oliver
O
Friedrich-Loeffler-Institute (FLI), 72076 Tübingen, Germany.
Pleschka
Stephan
S
Wolff
Thorsten
T
D000818:Animals; D001891:Borna disease virus / Q000276:immunology* / Q000472:pathogenicity*; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology / Q000821:virology*; D054884:Host-Pathogen Interactions; D015398:Signal Transduction