title: [Musculoskeletal tumor evaluation with 99mTc-Tetrofosmin].
abstract: BACKGROUND
  (99m)Tc-tetrofosmin is an efficient agent as a tumor marker. Several studies have proven its efficiency in detection and localization of tumors of the breast, larynx, thyroid, parathyroid glands, lung, brain, skin, lymphatic and musculoskeletal tissues with a sensitivity and specificity of 95% to 100%. It is used as a predictor of therapy efficacy and to localize remaining and recurrent tissue as well as local and distant extension.
  
  
  OBJECTIVE
  To determine the sensitivity, specificity and predictive values of the three-phase 99mTc-Tetrofosmin scan in detection of malignant lesions of the musculoskeletal tissue.
  
  
  METHODS
  Seventy-three patients of both genders with suspected malignant musculoskeletal lesions were studied by three-phase (vascular, tissue and delayed images) 99mTc-tectrofosmin scans.
  
  
  RESULTS
  One-hundred-percent sensitivity, 67.3% specificity, 55% positive predictive value, and 100% negative predictive value.
  
  
  CONCLUSIONS
  Three-phase 99mTc-tectrofosmin scan is useful in detection of malignant lesions of the musculoskeletal system due to its high sensitivity and positive predictive value. Nevertheless, benign pathology such as active inflammation is a source of false positives and the attending physician must consider the aid of complementary studies such as histopathology.
authors.affiliation: Instituto Nacional de Siquiatría, Departamento de Imágenes Cerebrales, Calzada México-Xochimilco Núm. 101 Huipulco, Tlalpan CP. 14370, DF México. grjuan@msn.com
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: García-Reyna
authors.forename: Genaro
authors.initials: G
authors.lastname: Rico Martínez
authors.forename: Iván F
authors.initials: IF
authors.lastname: Vega González
authors.forename: Luis Miguel
authors.initials: LM
authors.lastname: Linares
authors.forename: Ernesto A
authors.initials: EA
authors.lastname: Delgado Cedillo
authors.forename: Rosalba
authors.initials: R
authors.lastname: Romero Ramírez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000000981:diagnostic imaging*; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D055815:Young Adult
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin