Injectable poly(amidoamine)-poly(ethylene glycol)-poly(amidoamine) triblock copolymer hydrogel with dual sensitivities: pH and temperature.
A novel triblock copolymer for use in an injectable pH- and temperature-sensitive hydrogel is synthesized by conjugating poly(amidoamine) (PAA) to poly(ethylene glycol): poly(amidoamine)-poly(ethylene glycol)-poly(amidoamine) (PAA-PEG-PAA). The polymer was characterized with (1)H NMR and gel permeation chromatography in the diluents CDCl(3) and CHCl(3), respectively. The PAA block acts as a pH- and temperature-sensitive block. The PAA-PEG-PAA copolymer in aqueous solution (12.5 wt %) underwent a sol-gel transition as a function of pH and temperature. After injection into a rat, the copolymer solution (12.5 wt %) was immediately changed to a gel.
Nguyen
Minh Khanh
MK
Department of Polymer Science and Engineering, Sungkyunkwan University, Suwon, Gyeonggi-do 440-746, Korea.
Park
Dong Kuk
DK
Lee
Doo Sung
DS
D000818:Animals; D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007279:Injections, Subcutaneous; D009757:Nylons / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011073:Polyamines / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013696:Temperature
D001672:Biocompatible Materials; D009757:Nylons; C531249:Poly(amidoamine); D011073:Polyamines; D011108:Polymers; C542325:poly(amidoamine)-poly(ethylene glycol)-poly(amidoamine); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols