Towards quorum-quenching catalytic antibodies.
The development of a novel method to attenuate bacterial virulence is reported, which is based upon the use of designed transition-state analogues to select human catalytic antibodies capable of degrading bacterial quorum-sensing molecules.
Kapadnis
Prashant B
PB
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW. drspring@ch.cam.ac.uk.
Hall
Evan
E
Ramstedt
Madeleine
M
Galloway
Warren R J D
WR
Welch
Martin
M
Spring
David R
DR
D054742:Acyl-Butyrolactones / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D017151:Antibodies, Catalytic / Q000378:metabolism*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D006868:Hydrolysis; D053038:Quorum Sensing; D013450:Sulfones / Q000737:chemistry*
D054742:Acyl-Butyrolactones; D000900:Anti-Bacterial Agents; D017151:Antibodies, Catalytic; D001426:Bacterial Proteins; D013450:Sulfones