title: Percutaneous intragastric catheter (PIC) for administration of an unpalatable substance to large animals.
abstract: We studied an easy and reliable technique for administration of an unpalatable substance to large animals. There were three groups of pigs: group I (n = 6) received 1 g ethanol/kg body weight per day orally with water for 24 days, group II (n = 6) received 2 g ethanol/kg orally with water for 24 days and 4 g ethanol/kg via percutaneous intragastric catheter (PIC) for the next 24 days, group III (n = 6) received 6 g ethanol/kg via PIC for 72 days. The catheter was placed after insufflation of the stomach using an orogastric tube. PIC was successfully placed in each pig. No complications occurred during placement. The total amount of the administrated dose was assimilated each time. PIC is a safe, effective, well tolerated, and precise method of administering ethanol that is inexpensive and easy to perform. Ethanol administration via PIC is a convenient and effective mean of exposing animals to high levels of alcohol on a long-term basis.
authors.affiliation: Department of Surgery, University of Leipzig, Germany. m.schoen@klinikumkarlsruhe.de
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Oleszczuk
authors.forename: Michael M
authors.initials: MM
authors.lastname: Spannbauer
authors.forename: Matthias
authors.initials: M
authors.lastname: Bluher
authors.forename: Rudolf
authors.initials: R
authors.lastname: Ott
authors.forename: Uta-Carolin
authors.initials: UC
authors.lastname: Pietsch
authors.forename: Katja
authors.initials: K
authors.lastname: Schneider
authors.forename: Petra
authors.initials: P
authors.lastname: Madaj-Sterba
authors.forename: Manfred
authors.initials: M
authors.lastname: Furll
authors.forename: Johann P
authors.initials: JP
authors.lastname: Hauss
authors.forename: Michael R
authors.initials: MR
authors.lastname: Schön
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002404:Catheterization / Q000295:instrumentation / Q000379:methods* / Q000662:veterinary*; D000431:Ethanol / Q000008:administration & dosage*; D013270:Stomach; D034421:Sus scrofa; D013649:Taste
chemical_list: D000431:Ethanol