Therapeutic potential of mesenchymal stromal cells in a mouse breast cancer metastasis model.
OBJECTIVE
Mesenchymal stromal cells (MSC) have been studied intensively in regenerative medicine. However, their therapeutic potential against tumor formation and cancer metastasis is still unclear. The effects of transplantation of MSCs in early-stage of carcinogenesis, should be evaluated.


METHODS
MSC isolated from human umbilical cord blood (UCB) and adipose tissue (AD) were transplanted in a mouse cancer metastasis model. The effects of MSC on tumor growth and metastasis were analyzed. The effects of transplantation of MSC into the mouse model at very early stage carcinogenesis were also evaluated.


RESULTS
Human MSC reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis. In addition, transplantation of both UCB and AD MSC into a cancer model with no detectable clinical symptoms did not appear to promote tumor growth or metastasis.


CONCLUSIONS
We evaluated the effect of MSC derived from human UCB and AD tissue in a tumor model. Our findings may help to elucidate the interaction between cancer cells and MSC, as well as the application of MSC to clinical trials.
Sun
Bo
B
Zoonotic Disease Institute, College of Veterinary Medicine, Seoul National University, Seoul, Korea.
Roh
Kyoung-Hwan
KH
Park
Jeong-Ran
JR
Lee
Sae-Rom
SR
Park
Sang-Bum
SB
Jung
Ji-Won
JW
Kang
Soo-Kyung
SK
Lee
Yong-Soon
YS
Kang
Kyung-Sun
KS
D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism; D017209:Apoptosis; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D045744:Cell Line, Tumor; D018920:Coculture Techniques; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D011247:Pregnancy; D014410:Tumor Stem Cell Assay
D000943:Antigens, Differentiation; C499321:Parp1 protein, mouse; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases