title: Enhanced oral bioavailability of dexibuprofen by a novel solid self-emulsifying drug delivery system (SEDDS).
abstract: The main objective of this study was to prepare a solid form of lipid-based self-emulsifying drug delivery system (SEDDS) by spray drying liquid SEDDS with an inert solid carrier Aerosil 200 to improve the oral bioavailability of poorly water-soluble drug dexibuprofen. The liquid SEDDS was a system that consisted of dexibuprofen, Labrasol, Capryol 90 and Labrafil M 1944 CS. The particle size analysis revealed no difference in the z-average particle diameter of the reconstituted emulsion between liquid and solid SEDDS. The solid SEDDS was characterized by SEM, DSC and XRD studies. In vivo results of solid SEDDS and dexibuprofen powder in rats at the dose of 10mg/kg showed that the initial plasma concentrations of drug in solid SEDDS were significantly higher than those of dexibuprofen powder (P<0.05). The solid SEDDS gave significantly higher AUC and Cmax than did dexibuprofen powder (P<0.05). In particular, the AUC of solid SEDDS was about twofold higher than that of dexibuprofen powder. Our results suggested that this solid SEDDS could be used as an effective oral solid dosage form to improve the bioavailability of poorly water-soluble drug dexibuprofen.
authors.affiliation: College of Pharmacy, Yeungnam University, Gyongsan, South Korea.
authors.forename: Prabagar
authors.initials: P
authors.lastname: Balakrishnan
authors.forename: Beom-Jin
authors.initials: BJ
authors.lastname: Lee
authors.forename: Dong Hoon
authors.initials: DH
authors.lastname: Oh
authors.forename: Jong Oh
authors.initials: JO
authors.lastname: Kim
authors.forename: Myung Ja
authors.initials: MJ
authors.lastname: Hong
authors.forename: Jun-Pil
authors.initials: JP
authors.lastname: Jee
authors.forename: Jung Ae
authors.initials: JA
authors.lastname: Kim
authors.forename: Bong Kyu
authors.initials: BK
authors.lastname: Yoo
authors.forename: Jong Soo
authors.initials: JS
authors.lastname: Woo
authors.forename: Chul Soon
authors.initials: CS
authors.lastname: Yong
authors.forename: Han-Gon
authors.initials: HG
authors.lastname: Choi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems / Q000379:methods*; D004655:Emulsions / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007052:Ibuprofen / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D014961:X-Ray Diffraction
chemical_list: D004655:Emulsions; C539402:dexibuprofen; D007052:Ibuprofen