title: Successful desensitization by glargine administration in a patient with insulin allergy: a case report.
abstract: The patient was a 56-year-old man with type 2 diabetes and insulin allergy. He was administered glargine, which did not produce any allergic reactions, except for a small non-pruritic wheal. Thereafter, other insulin preparation could be administered. We consider this the first case of successful insulin desensitization by glargine administration.
authors.affiliation: Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. masumihara-tky@umin.ac.jp
authors.forename: Masumi
authors.initials: M
authors.lastname: Hara
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Izumida
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sato
authors.forename: Ken
authors.initials: K
authors.lastname: Ohashi
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Osuga
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Tobe
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Tsukamoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Kadowaki
mesh_terms: D003888:Desensitization, Immunologic / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000069036:Insulin Glargine; D007336:Insulin, Isophane / Q000009:adverse effects / Q000627:therapeutic use; D049528:Insulin, Long-Acting; D008297:Male; D008875:Middle Aged
chemical_list: D006442:Glycated Hemoglobin; D007328:Insulin; D000069036:Insulin Glargine; D007336:Insulin, Isophane; D049528:Insulin, Long-Acting