title: Immune and nervous systems share molecular and functional similarities: memory storage mechanism.
abstract: One of the most complex and important features of both the nervous and immune systems is their data storage and retrieval capability. Both systems encounter a common and complex challenge on how to overcome the cumbersome task of data management. Because each neuron makes many synapses with other neurons, they are capable of receiving data from thousands of synaptic connections. The immune system B and T cells have to deal with a similar level of complexity because of their unlimited task of recognizing foreign antigens. As for the complexity of memory storage, it has been proposed that both systems may share a common set of molecular mechanisms. Here, we review the molecular bases of memory storage in neurons and immune cells based on recent studies and findings. The expression of certain molecules and mechanisms shared between the two systems, including cytokine networks, and cell surface receptors, are reviewed. Intracellular signaling similarities and certain mechanisms such as diversity, memory storage, and their related molecular properties are briefly discussed. Moreover, two similar genetic mechanisms used by both systems is discussed, putting forward the idea that DNA recombination may be an underlying mechanism involved in CNS memory storage.
authors.affiliation: Medical Human Genetics Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: L
authors.initials: L
authors.lastname: Habibi
authors.forename: M
authors.initials: M
authors.lastname: Ebtekar
authors.forename: S B
authors.initials: SB
authors.lastname: Jameie
mesh_terms: D000818:Animals; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007156:Immunologic Memory / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D009424:Nervous System Physiological Phenomena