The potential of neural stem cells to repair stroke-induced brain damage.
Acute injuries to CNS such as stroke induce neural progenitor proliferation in adult brain which might be an endogenous attempt to self-repair. This process is known to be altered by several exogenous and endogenous modulators including growth factors that could help to reinforce the post-stroke neurogenesis. Increasing the neurogenesis may be a future therapeutic option to decrease the cognitive and behavioral deficits following stroke. In addition, transplantation of various types of stem cells into the injured brain is currently thought to be an exciting option to replace the neurons lost in the post-ischemic brain. These include immortalized stem cell lines, neural progenitors prepared from embryonic and adult animals and mesenchymal stem cells. Using exogenous stem cells in addition to modulating endogenous neurogenesis, we may be able to repair the injured brain after a devastating stroke. This article reviewed the current literature of these two issues.
Liu
Yi Ping
YP
Department of Neurological Surgery, University of Wisconsin, K4/8 Mail code CSC 8660, 600 Highland Ave, Madison, WI, 53792, USA.
Lang
Bradley T
BT
Baskaya
Mustafa K
MK
Dempsey
Robert J
RJ
Vemuganti
Raghu
R
D000818:Animals; D001930:Brain Injuries / Q000209:etiology / Q000473:pathology* / Q000523:psychology / Q000601:surgery*; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D001523:Mental Disorders / Q000209:etiology; D055495:Neurogenesis; D020127:Recovery of Function; D033581:Stem Cell Transplantation / Q000379:methods / Q000639:trends; D020521:Stroke / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D016896:Treatment Outcome