Millipede-like lymphocyte crawling: feeling the way with filopodia.
In this issue of Immunity, Shulman et al. (2009) describe shear-facilitated chemokine-induced adhesive filopodia on crawling T lymphocytes that scan the endothelial surface for potential sites of transendothelial migration. These filopodia facilitate a novel millipede-like mode of lymphocyte locomotion over endothelial cells prior to extravasation.
Ward
Stephen G
SG
Inflammatory Cell Biology Laboratory, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA27AY, UK. s.g.ward@bath.ac.uk
D000818:Animals; D002465:Cell Movement; D018925:Chemokines / Q000494:pharmacology; D042783:Endothelial Cells / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology / Q000502:physiology*; D008954:Models, Biological; D011554:Pseudopodia / Q000187:drug effects / Q000502:physiology*
D018925:Chemokines