[Study of association of the SNP19 polymorphism of calpain 10 gene with type 2 diabetes in ethnic sub-groups of the Tunisian population: gene-environment interaction].
Calpaïn 10 (CAPN10) is the first diabetes gene to be identified through a genome scan followed by positional cloning, encoding the cysteine protease, the calpaïn 10 encodes for a ubiquitously expressed protease implicated in the two fundamental pathophysiological aspects of T2DM insulinoresistance and insulinosecretion. Many investigators, but not all, have subsequently found association between calpaïn 10 polymorphism and type 2 diabetes (T2DM) as well as insulin action and insulin secretion. The aim of this study was to determine whether there is an association between specific polymorphism SNP19 in CAPN10 gene and T2DM in two ethnic groups from Djerba Island. Overall, 162 patients with type 2 of diabetes and 110 healthy volunteers who served as controls for genetic characterization with no family history of diabetes were included in the present study. They consisted of 159 women and 113 men. Their mean +/- SD age was 56,47 +/- 11,86 years. All subjects were genotyped according to SNP 19 polymorphism in CAPN10 gene with PCR method to perform case-control study. After adjusting for gender and age, we found an association with a high risk of T2DM in Djerba Island only in Arab sub-group.
Ouederni
T Baroudi
TB
Faculté des sciences de Tunis, Université El Manar II, Tunis, Tunisie. thourbar@yahoo.fr
Sanchez-Corona
J
J
Skhiri
H Aounallah
HA
Maiz
H Ben
HB
Abid
H Kammoun
HK
Benammar-Elgaaied
A
A
D000328:Adult; D000368:Aged; D018912:Arabs / Q000235:genetics; D001794:Blood Pressure; D015992:Body Mass Index; D002154:Calpain / Q000235:genetics*; D003001:Cloning, Molecular; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D004777:Environment; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance / Q000235:genetics; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking; D014416:Tunisia
D007328:Insulin; D002154:Calpain; C415197:calpain 10