Chiral recognition of mandelic acid by L-phenylalanine-modified sensor using quartz crystal microbalance.
This study presents a new method for the highly selective recognition of chiral mandelic acid (MA) using L-phenylalanine (L-Phe) as the selector. The proposed method is based on quartz crystal microbalance (QCM) detection, integrated with a vapor diffused molecular assembly (VDMA) reaction technique. The construction of the L-Phe-modified QCM sensor involved a two-step assembly procedure. The chiral recognizability of L- and D-MA on the L-Phe-modified surface was then examined using the VDMA method and QCM. The chiral discrimination factor between L- and D-MA detected by QCM, alpha(L-MA/D-MA), was found to be about 8. The VDMA selective sensing of L-MA on the L-Phe-modified surface was also confirmed by the contact angle measurements. The L-Phe-modified QCM sensor showed good stability and reusability. The present chiral recognition results suggest that L-phe is an excellent resolving agent for the resolution of chiral mandelic acid.
Guo
Hui-Shi
HS
Department of Chemistry, Shaoguan University, Shaoguan 512005, China. guohuishi@163.com
Kim
Jong-Min
JM
Chang
Sang-Mok
SM
Kim
Woo-Sik
WS
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004563:Electrochemistry; D007536:Isomerism; D008333:Mandelic Acids / Q000032:analysis* / Q000737:chemistry; D055616:Microtechnology; D010649:Phenylalanine / Q000737:chemistry*; D011791:Quartz; D012680:Sensitivity and Specificity; D013499:Surface Properties
D008333:Mandelic Acids; D011791:Quartz; D010649:Phenylalanine; C037938:mandelic acid