[Efficacy of cellulose on functional constipation].
OBJECTIVE
To assess the clinical efficacy and safety of cellulose on functional constipation.


METHODS
A prospective, self-controlled, multicenter clinical trial of cellulose was conducted for 2 weeks in 240 patients with functional constipation according to the Rome III( criteria. Symptoms and characters of feces before and after the treatment were observed and evaluated according to a score scheme.


RESULTS
In the 240 patients, the frequencies of defecation increased and the characters of feces was improved significantly after 2-week treatment. There were no adverse reactions observed throughout the clinical trial. The total efficacy was 82.1% at day 7 and 90.7% at day 14. The satisfactory rate of doctors was 83.8% and of patients was 83.8%.


CONCLUSIONS
Cellulose is effective and safe in the treatment of chronic functional constipation.
Liu
Bao-hua
BH
Research Institute of Surgery, Daping Hospital, Chongqing 400042, China. LBH57268@163.com
Yang
Xin-qing
XQ
Ren
Dong-lin
DL
Ding
Yi-jiang
YJ
Zhao
Ke
K
Qian
Qun
Q
Yang
Guan-gen
GG
Wang
Dong
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D002482:Cellulose / Q000627:therapeutic use*; D003248:Constipation / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D002482:Cellulose