Comparison between mucinous cystic neoplasm and intraductal papillary mucinous neoplasm of the branch duct type of the pancreas with respect to expression of CD10 and cytokeratin 20.
OBJECTIVE
Mucinous cystic neoplasm (MCN) and intraductal papillary mucinous neoplasm of the branch duct type (IPMN-BD) differ in biological and clinical behaviors, but MCN is often misdiagnosed as IPMN-BD. The purpose of this study was to find useful markers for the differential diagnosis of MCN and IPMN-BD.


METHODS
Immunohistochemically, the expression of the 2 types of mucin (MUC) 1 (MUC1/DF3 and MUC1/CORE), MUC2, MUC5AC, MUC6, human gastric mucin (HGM), caudal-related homeobox transcription factor 2 (CDX2), CD10, cytokeratin (CK) 7, and CK20 was examined in 7 cases of MCN and 16 cases of IPMN-BD.


RESULTS
Expression frequencies in MCN and IPMN-BD were 100% versus 44% for MUC1/DF3, 86% versus 31% for MUC1/CORE, 57% versus 19% for MUC2, 86% versus 100% for MUC5AC, 57% versus 88% for MUC6, 86% versus 100% for HGM, 57% versus 0% for CDX2, 71% versus 0% for CD10, 100% versus 69% for CK7, and 86% versus 6% for CK20.


CONCLUSIONS
Mucin 1/DF3, MUC1/CORE, CDX2, CD10, and CK20 were expressed significantly more frequently in MCN than in IPMN-BD. In particular, CD10 and CK20 showed marked differences in immunohistochemical sensitivity and specificity between MCN and IPMN-BD. It is therefore proposed that CD10 and CK20 may be used for the differential diagnosis of MCN and IPMN-BD.
Nishigami
Takashi
T
Department of Pathology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
Onodera
Masayuki
M
Torii
Ikuko
I
Sato
Ayuko
A
Tao
Li-Hua
LH
Kushima
Ryoji
R
Kakuno
Ayako
A
Kishimoto
Mitsuo
M
Katsuyama
Eiji
E
Fujimori
Takahiro
T
Hirano
Hiroshi
H
Satake
Makoto
M
Kuroda
Nobukazu
N
Nishiguchi
Shuhei
S
Fujimoto
Jiro
J
Tsujimura
Tohru
T
D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000378:metabolism / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000378:metabolism / Q000473:pathology*; D018282:Cystadenocarcinoma, Mucinous / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053554:Keratin-20 / Q000032:analysis*; D053552:Keratin-7 / Q000032:analysis; D008297:Male; D008875:Middle Aged; D055271:Mucin 5AC / Q000032:analysis; D018396:Mucin-1 / Q000032:analysis; D055262:Mucin-2 / Q000032:analysis; D055272:Mucin-6 / Q000032:analysis; D015260:Neprilysin / Q000032:analysis*; D010190:Pancreatic Neoplasms / Q000378:metabolism / Q000473:pathology*
D053554:Keratin-20; D053552:Keratin-7; D055271:Mucin 5AC; D018396:Mucin-1; D055262:Mucin-2; D055272:Mucin-6; D015260:Neprilysin