title: Induction of gene encoding FABP4 in Pten-null keratinocytes.
abstract: Keratinocyte-specific Pten-null mice revealed distinct phenotypes, including epidermal and sebaceous gland hyperplasia. To determine the candidate genes that contribute to their phenotypes, we analyzed a comprehensive gene expression of Pten-null keratinocytes using microarray technology. Consequently, it was demonstrated that the most induced gene was adipocyte-specific fatty acid-binding protein (FABP4). Collectively, it is conceivable that the FABP4 pathway mediates the sebaceous gland hyperplasia in keratinocyte-specific Pten-null mice.
authors.affiliation: Department of Dermatology and Plastic Surgery, Akita University School of Medicine, Hondo 1-1-1, Akita 010-8543, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Tsuda
authors.forename: Tae
authors.initials: T
authors.lastname: Inoue-Narita
authors.forename: Akira
authors.initials: A
authors.lastname: Suzuki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Itami
authors.forename: Miroslav
authors.initials: M
authors.lastname: Blumenberg
authors.forename: Motomu
authors.initials: M
authors.lastname: Manabe
mesh_terms: D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D020869:Gene Expression Profiling; D007150:Immunohistochemistry; D015603:Keratinocytes / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000502:physiology*
chemical_list: D017931:DNA Primers; C493411:Fabp4 protein, mouse; D050556:Fatty Acid-Binding Proteins; D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse