Home schooling of NK cells.
In this issue of Immunity, Chalifour et al. (2009) show that for natural killer (NK) cells to achieve their full effector potential, NK inhibitory receptors must developmentally interact with MHC-I ligands expressed in cis.
Margulies
David H
DH
Molecular Biology Section, Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1892, USA. dhm@nih.gov
D000818:Animals; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008024:Ligands; D008285:Major Histocompatibility Complex / Q000276:immunology*; D054340:Receptors, KIR / Q000378:metabolism*
D008024:Ligands; D054340:Receptors, KIR