Evaluating QTc in patients with advanced Parkinson's disease: overcoming artifact.
Electrocardiograms (ECGs) in patients with Parkinson's disease are affected by artifacts related to muscle tremor. Malik et al. report methods used in QTc study in patients with Parkinson's disease that markedly reduce the noise and variance of QTc in a sample of ECGs that are undeniably difficult to interpret. This study adds significant experience and novel methods that have the potential to further enhance the evaluation of the effect of a drug on QTc.
Bloomfield
D M
DM
1Cardiovascular Clinical Research, Merck Research Laboratories, Boston, Massachusetts, USA.
D000978:Antiparkinson Agents / Q000009:adverse effects / Q000494:pharmacology; D016477:Artifacts; D004562:Electrocardiography / Q000187:drug effects / Q000379:methods / Q000592:standards*; D006329:Heart Conduction System / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008133:Long QT Syndrome / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology; D010300:Parkinson Disease / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D014202:Tremor / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology
D000978:Antiparkinson Agents