Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases.
Phosphatidic acid (PA) production by receptor-stimulated phospholipase D is believed to play an important role in the regulation of cell function. The second messenger function of PA remains to be elucidated. PA can bind and affect the activities of different enzymes and here we summarise the current status of activation of Type I phosphatidylinositol 4-phosphate 5-kinase by PA. Type 1 phosphatidylinositol 4-phosphate 5-kinase is also regulated by ARF proteins as is phospholipase D and we discuss the contributions of ARF and PA towards phosphatidylinositol(4,5)bisphosphate synthesis at the plasma membrane.
Cockcroft
Shamshad
S
Department of Neuroscience, Physiology and Pharmacology, University College London, London, UK. S.cockcroft@ucl.ac.uk
D020727:ADP-Ribosylation Factors / Q000378:metabolism; D000595:Amino Acid Sequence; D024361:Amino Acids, Basic / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D008969:Molecular Sequence Data; D010712:Phosphatidic Acids / Q000378:metabolism*; D010739:Phospholipase D / Q000378:metabolism; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000737:chemistry / Q000378:metabolism*
D024361:Amino Acids, Basic; D010712:Phosphatidic Acids; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase; D010739:Phospholipase D; D020727:ADP-Ribosylation Factors