Tightening the connections between cadherins and fibronectin matrix.
Fibronectin extracellular matrix is assembled and remodeled throughout embryogenesis and plays key roles in early vertebrate development. In this issue of Developmental Cell, Dzamba et al. reveal, through their studies of Xenopus embryos, a novel mechanism for regulating fibronectin matrix assembly through Wnt signaling and cadherin-mediated cell-cell adhesion.
Hunt
Geoffrey C
GC
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Schwarzbauer
Jean E
JE
D000818:Animals; D015820:Cadherins / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D005353:Fibronectins / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D015398:Signal Transduction; D051153:Wnt Proteins / Q000502:physiology
D015820:Cadherins; D005353:Fibronectins; D051153:Wnt Proteins