title: Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for gram positive infections.
abstract: CA-MRSA isolates are increasingly common pathogens in children with acute, hematogenously acquired osteomyelitis and clinicians have to consider this pathogen in the selection of initial empiric treatment. With the emergence of pvl+ CA-MRSA isolates, unusual manifestations of acute osteomyelitis have become common including venous thromboses and multiple sites of infection. MRI is currently the imaging modality of choice for osteomyelitis. Drainage of purulent collections is also more common in association with the pvl+ strains. The role of newer antibiotics such as linezolid and daptomycin for the treatment of CA-MRSA musculoskeletal infections in children needs further study.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA. skaplan@bcm.tmc.edu
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Kaplan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002675:Child, Preschool; D019468:Disease Management; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D010019:Osteomyelitis / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents