title: Comparable survival between HIV+ and HIV- non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation.
abstract: Autologous stem cell transplantation (ASCT) has been successfully used in HIV-related lymphoma (HIV-Ly) patients on highly active antiretroviral therapy. We report the first comparative analysis between HIV-Ly and a matched cohort of HIV(-) lymphoma patients. This retrospective European Group for Blood and Marrow Transplantation study included 53 patients (66% non-Hodgkin and 34% Hodgkin lymphoma) within each cohort. Both groups were comparable except for the higher proportion of males, mixed-cellularity Hodgkin lymphoma and patients receiving granulocyte colony-stimulating factor before engraftment and a smaller proportion receiving total body irradiation-based conditioning within the HIV-Ly cohort. Incidence of relapse, overall survival, and progression-free survival were similar in both cohorts. A higher nonrelapse mortality within the first year after ASCT was observed in the HIV-Ly group (8% vs 2%), predominantly because of early bacterial infections, although this was not statistically significant and did not influence survival. Thus, within the highly active antiretroviral therapy era, HIV patients should be considered for ASCT according to the same criteria adopted for HIV(-) lymphoma patients.
authors.affiliation: Hematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain. jdiez.hgugm@salud.madrid.org
authors.forename: José L
authors.initials: JL
authors.lastname: Díez-Martín
authors.forename: Pascual
authors.initials: P
authors.lastname: Balsalobre
authors.forename: Alessandro
authors.initials: A
authors.lastname: Re
authors.forename: Mariagrazia
authors.initials: M
authors.lastname: Michieli
authors.forename: José M
authors.initials: JM
authors.lastname: Ribera
authors.forename: Carmen
authors.initials: C
authors.lastname: Canals
authors.forename: Eulogio
authors.initials: E
authors.lastname: Conde
authors.forename: Anne
authors.initials: A
authors.lastname: Rosselet
authors.forename: Ian
authors.initials: I
authors.lastname: Gabriel
authors.forename: Rosario
authors.initials: R
authors.lastname: Varela
authors.forename: Bernardino
authors.initials: B
authors.lastname: Allione
authors.forename: Kate
authors.initials: K
authors.lastname: Cwynarski
authors.forename: Philippe
authors.initials: P
authors.lastname: Genet
authors.forename: Ildefonso
authors.initials: I
authors.lastname: Espigado
authors.forename: Pierre
authors.initials: P
authors.lastname: Biron
authors.forename: Norbert
authors.initials: N
authors.lastname: Schmitz
authors.forename: Anne E
authors.initials: AE
authors.lastname: Hunter
authors.forename: Augustin
authors.initials: A
authors.lastname: Ferrant
authors.forename: Gaelle
authors.initials: G
authors.lastname: Guillerm
authors.forename: Mark
authors.initials: M
authors.lastname: Hentrich
authors.forename: Manuel
authors.initials: M
authors.lastname: Jurado
authors.forename: Pascual
authors.initials: P
authors.lastname: Fernández
authors.forename: David
authors.initials: D
authors.lastname: Serrano
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Rossi
authors.forename: Anna
authors.initials: A
authors.lastname: Sureda
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000601:surgery*; D006689:Hodgkin Disease / Q000209:etiology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D036102:Peripheral Blood Stem Cell Transplantation; D015996:Survival Rate; D014182:Transplantation, Autologous