title: Highly enantioselective construction of axial chirality by palladium-catalyzed cycloisomerization of N-alkenyl arylethynylamides.
abstract: A cationic palladium(II)/(S)-xyl-Segphos complex catalyzes enantioselective cycloisomerizations of N-alkenyl arylethynylamides leading to axially chiral 4-aryl-2-pyridones in high yields with high ee values. The present catalysis represents the first enantioselective construction of axial chirality by the transition-metal-catalyzed cycloisomerization.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, and Instrumentation Analysis Center, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
authors.forename: Hidetomo
authors.initials: H
authors.lastname: Imase
authors.forename: Takeshi
authors.initials: T
authors.lastname: Suda
authors.forename: Yu
authors.initials: Y
authors.lastname: Shibata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Noguchi
authors.forename: Masao
authors.initials: M
authors.lastname: Hirano
authors.forename: Ken
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011728:Pyridones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D011728:Pyridones; D010165:Palladium