title: In vitro potency of doripenem tested against an international collection of rarely isolated bacterial pathogens.
abstract: Doripenem, a new 1beta-methyl parenteral carbapenem, has very broad-spectrum activity against Gram-positive and Gram-negative aerobic bacteria. As noted here, the spectrum and potency extended to many rarely isolated species sampled by the Doripenem Global Surveillance Program. Among the species or species groups with <or=0.14% prevalence (1959 strains tested), doripenem was active against 98.9% of Enterobacteriaceae at <or=0.5 microg/mL. Similarly, more than 90% of other rarely isolated Gram-negative species isolates (Aeromonas spp., Delftia acidovorans, Haemophilus parainfluenzae, Neisseria meningitidis, Ochrobactrum anthropi, Pasteurella multocida, Pseudomonas oryzihabitans, and Pseudomonas stutzeri) were inhibited by <or=2 microg/mL of doripenem. The low-prevalence Gram-positive pathogens were generally less doripenem susceptible with MIC(90) results at >0.25 microg/mL for all tested species except Lactococcus garvieae, Listeria monocytogenes, and Micrococcus spp. In conclusion, doripenem exhibited a very wide spectrum but variable potencies against uncommonly cultured aerobic bacterial pathogens isolated in 2003 to 2007. These results confirm the potential use of this new carbapenem for broad-spectrum empiric or directed antimicrobial therapy.
authors.affiliation: JMI Laboratories, North Liberty, IA 52317, USA. ronald-jones@jmilabs.com
authors.forename: Ronald N
authors.initials: RN
authors.lastname: Jones
authors.forename: Jan M
authors.initials: JM
authors.lastname: Bell
authors.forename: Helio S
authors.initials: HS
authors.lastname: Sader
authors.forename: John D
authors.initials: JD
authors.lastname: Turnidge
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Stilwell
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D000077726:Doripenem; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000382:microbiology; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D000077726:Doripenem