PIK3CA mutations in human solid tumors: role in sensitivity to various therapeutic approaches.
Phosphatidylinositol 3-kinases (PI3Ks) are a group of lipid kinases that regulate signaling pathways involved in cell proliferation, adhesion, survival and motility. The PI3K pathway is considered to play an important role in tumorigenesis. Activating mutations of the p110alpha subunit of PI3K (PIK3CA) have been identified in a broad spectrum of tumors. Analyses of PIK3CA mutations reveals that they increase the PI3K signal, stimulate downstream Akt signaling, promote growth factor-independent growth and increase cell invasion and metastasis. In this review, we analyze the contribution of the PIK3CA mutations in cancer, and their possible implications for diagnosis and therapy.
Ligresti
Giovanni
G
Department of Biomedical Sciences, University of Catania, Catania, Italy.
Militello
Loredana
L
Steelman
Linda S
LS
Cavallaro
Andrea
A
Basile
Francesco
F
Nicoletti
Ferdinando
F
Stivala
Franca
F
McCubrey
James A
JA
Libra
Massimo
M
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D058534:Class I Phosphatidylinositol 3-Kinases; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology* / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000737:chemistry / Q000235:genetics*; D015398:Signal Transduction
D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human