Convergence time to the Ewens sampling formula in the infinite alleles Moran model.
In this paper, we establish an upper bound for time to convergence to stationarity for the discrete time infinite alleles Moran model. If M is the population size and mu is the mutation rate, this bound gives a cutoff time of log(Mmu)/mu generations. The stationary distribution for this process in the case of sampling without replacement is the Ewens sampling formula. We show that the bound for the total variation distance from the generation t distribution to the Ewens sampling formula is well approximated by one of the extreme value distributions, namely, a standard Gumbel distribution. Beginning with the card shuffling examples of Aldous and Diaconis and extending the ideas of Donnelly and Rodrigues for the two allele model, this model adds to the list of Markov chains that show evidence for the cutoff phenomenon. Because of the broad use of infinite alleles models, this cutoff sets the time scale of applicability for statistical tests based on the Ewens sampling formula and other tests of neutrality in a number of population genetic studies.
Watkins
Joseph C
JC
Department of Mathematics, University of Arizona, Tucson, AZ 85721, USA. jwatkins@math.arizona.edu
D000483:Alleles; D014644:Genetic Variation; D006801:Humans; D008390:Markov Chains; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D011156:Population Density; D018401:Sample Size; D012494:Sampling Studies; D015983:Selection Bias