title: Quantitative analysis of fecal sapovirus shedding: identification of nucleotide substitutions in the capsid protein during prolonged excretion.
abstract: Sapovirus (SaV) is an important pathogen causing gastroenteritis in humans. Quantitative analysis of the viral loads in feces collected from two SaV outbreaks was performed. Our results showed that SaV excretion generally decreased to an undetectable level in 2 weeks; however, some individuals excrete SaV in feces at high concentrations for 2-4 weeks after the onset of illness. In addition, we identified for the first time nucleotide changes in the capsid region during prolonged excretion.
authors.affiliation: Miyazaki Prefectural Institute for Public Health and Environment, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Iwakiri
authors.forename: Hidenari
authors.initials: H
authors.lastname: Ganmyo
authors.forename: Seigo
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Kayoko
authors.initials: K
authors.lastname: Otao
authors.forename: Mieko
authors.initials: M
authors.lastname: Mikasa
authors.forename: Sigeko
authors.initials: S
authors.lastname: Kizoe
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Katayama
authors.forename: Takaji
authors.initials: T
authors.lastname: Wakita
authors.forename: Naokazu
authors.initials: N
authors.lastname: Takeda
authors.forename: Tomoichiro
authors.initials: T
authors.lastname: Oka
mesh_terms: D000293:Adolescent; D000328:Adult; D017250:Caliciviridae Infections / Q000821:virology*; D036022:Capsid Proteins / Q000235:genetics*; D002648:Child; D005243:Feces / Q000821:virology*; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D017354:Point Mutation; D029341:Sapovirus / Q000235:genetics* / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D017201:Virus Shedding; D055815:Young Adult
chemical_list: D036022:Capsid Proteins