title: Congenital biliary atresia: liver injury begins at birth.
abstract: BACKGROUND
  The timing of onset of liver injury in biliary atresia (BA) is not known, although in approximately 10% of cases, biliary pathologic condition associated with the biliary atresia splenic malformation syndrome must begin well before birth.
  
  
  METHODS
  The study involved retrospective case-note review for infants with definite BA who underwent laparotomy within first week of life.
  
  
  RESULTS
  Three infants were identified who had occlusive BA evident on the first day of life. In all cases, their liver was grossly normal, and histologic changes were trivial.
  
  
  CONCLUSIONS
  This suggests that the detrimental cholestatic liver injury, later characteristic of BA, only begins from the time of birth despite a prenatal occlusive biliary pathology. It may be that tissue injury only occurs with the onset of the perinatal bile surge initiating periductal bile leakage and the triggering of an inflammatory and ultimately fibrotic response.
authors.affiliation: Department of Paediatric Surgery, King's College Hospital, London.
authors.forename: Erica
authors.initials: E
authors.lastname: Makin
authors.forename: Alberto
authors.initials: A
authors.lastname: Quaglia
authors.forename: Nina
authors.initials: N
authors.lastname: Kvist
authors.forename: Bodil Laub
authors.initials: BL
authors.lastname: Petersen
authors.forename: Bernard
authors.initials: B
authors.lastname: Portmann
authors.forename: Mark
authors.initials: M
authors.lastname: Davenport
mesh_terms: D001656:Biliary Atresia / Q000097:blood / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D001663:Bilirubin / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D005355:Fibrosis; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies
chemical_list: D001663:Bilirubin