title: Serum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum.
abstract: The aim of this study was to investigate lipid profile, paraoxonase 1 (PON1) activity, and oxidative stress status in the serum of hyperemesis gravidarum (HG) patients. Thirty-six HG cases and 36 normal pregnants were included in the study. Serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apoproteins A1 (apo A1) and B (apo B), malondialdehyde (MDA), and total antioxidant activity (TAO) values and PON1 and arylesterase activities were determined. Although serum TC, TG, LDL-C, and apo B levels were not different among; the groups (P>0.05), HDL-C (P=0.01) and apo A1 (P=0.007) levels were lower in HG patients than in normal pregnants. HG group had significantly lower serum PON1 (P=0.03) and arylesterase activities (P=0.03) compared with the control group. Additionally, mean TAO values were lower (P=0.01) and MDA levels were higher (P=0.02) in HG group than in the healthy pregnants. A significant negative correlation between PON1 and MDA was found in HG group (r=-0.33, P<0.05). The findings of this study have revealed that HG may be one of the conditions in which oxidant and antioxidant balance is impaired.
authors.affiliation: Department of Biochemistry, School of Medicine, Ataturk University, Erzurum, Turkey. aksoyhulya@yahoo.com
authors.forename: Hulya
authors.initials: H
authors.lastname: Aksoy
authors.forename: Ayse Nur
authors.initials: AN
authors.lastname: Aksoy
authors.forename: Asuman
authors.initials: A
authors.lastname: Ozkan
authors.forename: Harun
authors.initials: H
authors.lastname: Polat
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000378:metabolism*; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008315:Malondialdehyde / Q000032:analysis; D018384:Oxidative Stress; D011247:Pregnancy; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human