title: [Efficacy of polyglycosides of Tripterygium wilfordii in preventing postoperative recurrence of Crohn disease].
abstract: OBJECTIVE
  To observe the efficacy of polyglycoside of Tripterygium wilfordii(GTW) in preventing postoperative recurrence of Crohn disease(CD).
  
  
  METHODS
  Thirty-nine post-operative CD patients in whom all of the diseased gut had been removed from January 2005 to December 2006 were enrolled in a randomized, placebo-controlled trial. The patients took GTW(21 cases) or SASP(18 cases) in two weeks after operation. Crohn disease activity index(CDAI), ESR and CRP were collected at week 0, 13, 26, 52 or at the onset of symptoms. Ileocolonoscopy was performed at the end of the trial or at the onset of symptoms.
  
  
  RESULTS
  One patient in GTW group and 2 patients in SASP group were lost and 2 patients in GTW were excluded from the trial for non-compliance. Clinical recurrence was ascertained in one patient (5.6%) received GTW and in four (25.0%) received SASP. Four of eighteen patients in GTW(22.2%) had endoscopic recurrence compared with nine of sixteen(56.2%) in SASP. There were significant differences between the two groups(P<0.05).
  
  
  CONCLUSIONS
  Tripterygium wilfordii showed good efficacy in preventing recurrence of postoperative CD which can maintain remission and prevent recurrence.
authors.affiliation: Department of General Surgery, Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing 210002, China. .
authors.forename: Nan-sheng
authors.initials: NS
authors.lastname: Liao
authors.forename: Jian-an
authors.initials: JA
authors.lastname: Ren
authors.forename: Chao-gang
authors.initials: CG
authors.lastname: Fan
authors.forename: Ge-fei
authors.initials: GF
authors.lastname: Wang
authors.forename: Yun-zhao
authors.initials: YZ
authors.lastname: Zhao
authors.forename: Jie-shou
authors.initials: JS
authors.lastname: Li
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011184:Postoperative Period; D055502:Secondary Prevention; D016896:Treatment Outcome; D029757:Tripterygium
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides