title: Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea.
abstract: Four new xanthones, butyraxanthones A-D (1-4), were isolated from the stem bark of Pentadesma butyracea, together with six known xanthones (5-10) and a triterpenoid (lupeol). The structures of 1-4 were established by spectroscopic methods. Compounds 1-10 were tested in vitro for antiplasmodial activity against a Plasmodium falciparum chloroquine-resistant strain and for cytotoxicity against a human breast cancer cell line (MCF-7). Nearly all of these xanthones exhibited good antiplasmodial activity, and some of them also demonstrated potent cytotoxicity.
authors.affiliation: UMR 5557 CNRS, Département de Pharmacognosie, Faculté de Pharmacie, Université de Lyon, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France.
authors.forename: Fabien
authors.initials: F
authors.lastname: Zelefack
authors.forename: David
authors.initials: D
authors.lastname: Guilet
authors.forename: Nicolas
authors.initials: N
authors.lastname: Fabre
authors.forename: Christine
authors.initials: C
authors.lastname: Bayet
authors.forename: Séverine
authors.initials: S
authors.lastname: Chevalley
authors.forename: Silvère
authors.initials: S
authors.lastname: Ngouela
authors.forename: Bruno Ndjakou
authors.initials: BN
authors.lastname: Lenta
authors.forename: Alexis
authors.initials: A
authors.lastname: Valentin
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo
authors.forename: Marie-Geneviève
authors.initials: MG
authors.lastname: Dijoux-Franca
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002163:Cameroon; D002738:Chloroquine / Q000494:pharmacology; D028084:Clusiaceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones; D002738:Chloroquine