Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis.
A series of novel enantiomerically pure azole derivatives was synthesized. The new compounds, bearing both an imidazole as well as a triazole moiety, were evaluated as antimycobacterial agents. One of them proved to have activity against Mycobaterium tuberculosis comparable to those of the classical antibacterial/antifungal drugs Econazole and Clotrimazole.
Castagnolo
Daniele
D
Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Siena, Italy.
Radi
Marco
M
Dessì
Filippo
F
Manetti
Fabrizio
F
Saddi
Manuela
M
Meleddu
Rita
R
De Logu
Alessandro
A
Botta
Maurizio
M
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development*; D013237:Stereoisomerism
D000995:Antitubercular Agents; D001393:Azoles