Impact of liver cirrhosis on mortality in patients with community-acquired bacteremia.
Few studies have analyzed the impact of liver cirrhosis, a clinically significant comorbid medical condition, on the mortality of patients with community-acquired bacteremia. We conducted an observational study of 839 consecutive community-acquired bacteremia patients who were hospitalized through the emergency department (ED). We compared the 30-day mortality of bacteremia patients with and without liver cirrhosis using Cox proportional hazards regression. The probability of survival at day 30 was significantly different for the cirrhotic and noncirrhotic groups (53% versus 82%, respectively; P < 0.001 by the log-rank test). Multivariate analysis indicated that liver cirrhosis was associated with an increased risk of short-term mortality (hazard ratio, 2.0; 95% confidence interval, 1.1-3.5), as well as age, higher comorbidity index, and markers obtained from clinical presentation at ED. In conclusion, in addition to the effects from other prognostic factors, liver cirrhosis has a significant impact on the mortality of patients with community-acquired bacteremia.
Chen
Shey-Ying
SY
Department of Emergency Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Tsai
Chu-Lin
CL
Lin
Chien-Hao
CH
Lee
Chien-Chang
CC
Chiang
Wen-Chu
WC
Wang
Jiun-Ling
JL
Ma
Matthew Huei-Ming
MH
Chen
Shyr-Chyr
SC
Chen
Wen-Jone
WJ
Chang
Shan-Chwen
SC
D000367:Age Factors; D000368:Aged; D016470:Bacteremia / Q000150:complications* / Q000401:mortality*; D017714:Community-Acquired Infections / Q000150:complications* / Q000401:mortality*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors