title: A new dicoumarin and anticoagulant activity from Viola yedoensis Makino.
abstract: A new dicoumarin, named as dimeresculetin (1), together with another dicoumarin, euphorbetin (2) and esculetin (3) were isolated from the ethyl acetate extract of the dried whole plants of Viola yedoensis Makino. The structure of 1 was elucidated as 7-hydroxy-6-[(6,7-dihydroxy-2-oxo-2H-1-benzopyran-5-yl)oxy]-2H-1-benzopyran-2-one on the basis of extensive NMR, as well as the other spectral analysis. Compounds 1-3 exhibited anticoagulant activities with respect to activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT).
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, China. liliaceae@126.com
authors.forename: Hai Yan
authors.initials: HY
authors.lastname: Zhou
authors.forename: Jun Li
authors.initials: JL
authors.lastname: Hong
authors.forename: Pan
authors.initials: P
authors.lastname: Shu
authors.forename: Yue Juan
authors.initials: YJ
authors.lastname: Ni
authors.forename: Min Jian
authors.initials: MJ
authors.lastname: Qin
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification*; D001728:Dicumarol / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D010314:Partial Thromboplastin Time; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry; D011517:Prothrombin Time; D011817:Rabbits; D013918:Thrombin Time; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032413:Viola / Q000737:chemistry*
chemical_list: C543238:7-hydroxy-6-((6,7-dihydroxy-2-oxo-2H-1-benzopyran-5-yl)oxy)-2H-1-benzopyran-2-one; D000925:Anticoagulants; D003374:Coumarins; D010936:Plant Extracts; D014468:Umbelliferones; C543239:euphorbetin; D001728:Dicumarol; D006493:Heparin; C007628:esculetin