Levels of serum deoxyribonuclease I activity on admission in patients with acute myocardial infarction can be useful in predicting left ventricular enlargement due to remodeling.
OBJECTIVE
Serum deoxyribonuclease I (DNase I) activity has recently been highlighted as a potential diagnostic marker for the early detection of an acute myocardial infarction (AMI). We evaluated whether the serum DNase I activity was associated with the parameters of the left ventricular (LV) remodeling after an AMI.


METHODS
We measured the serum DNase I activity in 45 patients with an AMI who were admitted to our hospital within approximately 4 h of the onset of their chest pain. We also evaluated the LV ejection fraction (LVEF), LV end-diastolic volume (LVEDV), and LV end-systolic volume (LVESV) of each patient by echocardiography at the time of admission and at 6 months after the onset of the AMI.


RESULTS
The serum DNase I activity peaked at 3.5+/-2.0 h after the onset of the symptoms in the patients with an AMI, thereafter exhibiting a time-dependent decline within 12 h, and a return to the basal level within 24 h in almost all cases. Neither the LVEF, LVEDV, nor LVESV in each patient on admission exhibited a significant correlation to the peak levels of the serum DNase I activity. Although there was no correlation between the peak DNase I activity and LVEF at 6 months after the onset, a significant positive correlation of the peak DNase I activity with LVEDV and LVESV (r=0.48, p<0.001 and r=0.34, p=0.02, respectively) was found. Furthermore, the LVEDV at 6 months after the onset in the high DNase I activity group (> 17.9 U/L) were significantly higher than those in the low DNase I activity group (< or = 17.9 U/L) (118.0+/-28.2 ml vs 89.3+/-25.4 ml, p=0.026).


CONCLUSIONS
The serum DNase I activity level may predict LV enlargement associated with remodeling after an AMI.
Kuribara
Jun
J
Department of Cardiology, Gunma University Graduate School of Medicine, 39-15-3 Showa, Maebashi, Gunma 371-8511, Japan. kurihaj@yahoo.co.jp
Tada
Hiroshi
H
Kawai
Yasuyuki
Y
Kawaguchi
Ren
R
Hoshizaki
Hiroshi
H
Arakawa
Kenichiro
K
Kitayama
Michihiko
M
Kajinami
Kouji
K
Kurabayashi
Masahiko
M
Oshima
Shigeru
S
Taniguchi
Koichi
K
Kominato
Yoshihiko
Y
Yasuda
Toshihiro
T
D000368:Aged; D015415:Biomarkers / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D003850:Deoxyribonuclease I / Q000097:blood*; D003955:Diagnostic Tests, Routine; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000201:enzymology / Q000473:pathology*; D013318:Stroke Volume; D020257:Ventricular Remodeling / Q000502:physiology*
D015415:Biomarkers; D003402:Creatine Kinase; D003850:Deoxyribonuclease I