title: Anaphylaxis in patients with congenital bleeding disorders and inhibitors.
abstract: Anaphylactic reactions are rare emergencies observed in patients with inherited bleeding disorders. When these adverse events occur in patients with inhibitors, they further complicate the management of an already challenging clinical situation. Anaphylactoid inhibitors have been reported in patients with inhibitors associated with hemophilia A, hemophilia B, and type 3 von Willebrand disease. In this review, we summarize the current literature data on the occurrence of anaphylactoid reactions in patients with inherited bleeding disorders and alloantibodies. In particular, we focus on the pathophysiology of the inhibitor development and its management.
authors.affiliation: Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Franchini
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lippi
authors.forename: Martina
authors.initials: M
authors.lastname: Montagnana
authors.forename: Giovanni
authors.initials: G
authors.lastname: Targher
authors.forename: Marco
authors.initials: M
authors.lastname: Zaffanello
authors.forename: Gian Luca
authors.initials: GL
authors.lastname: Salvagno
authors.forename: Gianna Franca
authors.initials: GF
authors.lastname: Rivolta
authors.forename: Caterina
authors.initials: C
authors.lastname: Di Perna
authors.forename: Annarita
authors.initials: A
authors.lastname: Tagliaferri
mesh_terms: D000707:Anaphylaxis / Q000097:blood* / Q000209:etiology*; D025861:Blood Coagulation Disorders, Inherited / Q000097:blood* / Q000150:complications*; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D006801:Humans; D007518:Isoantibodies / Q000097:blood*
chemical_list: D019774:Blood Coagulation Factor Inhibitors; D007518:Isoantibodies