title: Lack of efficacy of prophylactic platelet transfusion for severe thrombocytopenia in adults with acute uncomplicated dengue infection.
abstract: Thrombocytopenia in dengue infection raises concerns about bleeding risk. Of 256 patients with dengue infection who developed thrombocytopenia (platelet count, < 20 x 10(3) platelets/microL) without prior bleeding, 188 were given platelet transfusion. Subsequent bleeding, platelet increment, and platelet recovery were similar between patients given transfusion and patients not given transfusion. Prophylactic platelet transfusion was ineffective in preventing bleeding in adult patients with dengue infection.
authors.affiliation: Department of Infectious Disease, Tan Tock Seng Hospital, National Healthcare Group, Singapore.
authors.forename: David C
authors.initials: DC
authors.lastname: Lye
authors.forename: Vernon J
authors.initials: VJ
authors.lastname: Lee
authors.forename: Yan
authors.initials: Y
authors.lastname: Sun
authors.forename: Yee Sin
authors.initials: YS
authors.lastname: Leo
mesh_terms: D000293:Adolescent; D000328:Adult; D003715:Dengue / Q000150:complications*; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D017713:Platelet Transfusion; D020127:Recovery of Function; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000517:prevention & control*; D016896:Treatment Outcome; D055815:Young Adult