title: Adjunctive measures for treating surgical infections and sepsis.
abstract: The history of adjunctive treatments for severe sepsis has been fraught with more failures than successes. To date, there have been few interventions that have been demonstrated to be efficacious by multiple large, well-designed, multicenter randomized clinical trials. However, recent research into treatment strategies using drotrecogin alfa (activated), effective blood glucose management, early goal-directed therapy, protocolization of care, and intensivist management has demonstrated positive results. Further research is being conducted to verify the success of these initial trials. This article summarizes some of the available adjunctive treatments for severe sepsis.
authors.affiliation: Department of Trauma, Division of Surgical Critical Care, University of Minnesota, Minneapolis, MN 55455, USA. byrne147@umn.edu
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Byrnes
authors.forename: Greg J
authors.initials: GJ
authors.lastname: Beilman
mesh_terms: D002986:Clinical Trials as Topic; D003422:Critical Care; D005440:Fluid Therapy / Q000379:methods; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control; D007328:Insulin / Q000627:therapeutic use; D011486:Protein C / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000627:therapeutic use; D012151:Resuscitation / Q000379:methods; D018805:Sepsis / Q000628:therapy*; D013530:Surgical Wound Infection / Q000628:therapy*
chemical_list: D007328:Insulin; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated