Comparison of hypoglycemic activity of trace elements absorbed in fermented mushroom of Coprinus comatus.
The effect of fermented mushroom of Coprinus comatus rich in trace elements, including vanadium, chromium, zinc, magnesium, copper, iron, and nickel, on glycemic metabolism was studied in this paper. Alloxan-induced hyperglycemic mice were used in the study. The blood glucose, glycohemoglobin, and glycogen synthesis of the mice were analyzed, respectively. At the same time, the gluconeogenesis of the normal mice was also determined. After the mice were administered (ig) with C. comatus rich in vanadium (CCRV), the blood glucose and the glycohemoglobin of alloxan-induced hyperglycemic mice decreased (p < 0.05, p < 0.01), glycogen synthesis of alloxan-induced hyperglycemic mice elevated (p < 0.01), the gluconeogenesis of the normal mice was inhibited (p < 0.01), and the sugar tolerance of the normal mice was improved. However, the same result did not occur in other groups. Vanadium at lower doses in combination with C. comatus induced significant effect on glycemic metabolism in mice.
Lv
Yingtao
Y
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao, People's Republic of China.
Han
Linna
L
Yuan
Chao
C
Guo
Jianyou
J
D000496:Alloxan; D000818:Animals; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D002857:Chromium / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D003302:Coprinus / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D015536:Down-Regulation; D005260:Female; D005285:Fermentation; D005943:Gluconeogenesis; D006442:Glycated Hemoglobin / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D019216:Metals, Heavy / Q000494:pharmacology*; D051379:Mice; D008820:Mice, Obese; D012015:Reference Standards; D014639:Vanadium / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D000496:Alloxan; D001786:Blood Glucose; D002857:Chromium; D003300:Copper; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007501:Iron; D019216:Metals, Heavy; D014639:Vanadium; D015032:Zinc