PUPylation: something old, something new, something borrowed, something Glu.
Most eukaryotic proteins are degraded by the 26S proteasome as a consequence of their covalent modification with ubiquitin. Although the proteasome is found in some prokaryotes, ubiquitin is not, which indicates that substrates are targeted to prokaryotic proteasomes by a fundamentally different mechanism. A recent study has identified Pup (prokaryotic ubiquitin-like protein) as a mycobacterial protein that functions in a manner analogous to ubiquitin for proteasome-dependent proteolysis in prokaryotes.
DeMartino
George N
GN
Department of Physiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9040, USA. george.demartino@utsouthwestern.edu
D001426:Bacterial Proteins / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D054875:Ubiquitination; D014452:Ubiquitins / Q000378:metabolism*
D001426:Bacterial Proteins; D014452:Ubiquitins; D018698:Glutamic Acid; D046988:Proteasome Endopeptidase Complex