Repeated occurrence of clozapine-induced myocarditis in a patient with schizoaffective disorder and comorbid Parkinson's disease.
Myocarditis is a rare but life threatening adverse effect of clozapine. Some symptoms of myocarditis--elevated temperature, tachycardia and fatigue--appear commonly during the onset of treatment with clozapine and during the dose titration. We present a case of a patient with concurrent schizoaffective disorder and Parkinson's disease, who twice developed clozapine-induced myocarditis. All symptoms disappeared after the discontinuation of the drug. Early diagnosis, discontinuation of clozapine and supportive therapy of myocarditis lower the risk of a fatal outcome.
Masopust
Jiri
J
Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové, and University Hospital Hradec Králové, Hradec Králové, Czech Republic.
Urban
Ales
A
Valis
Martin
M
Malý
Radovan
R
Tůma
Ivan
I
Hosák
Ladislav
L
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009205:Myocarditis / Q000139:chemically induced*; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy; D010507:Periodicity; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy*; D012008:Recurrence
D014150:Antipsychotic Agents; D003024:Clozapine