title: A detection system based on giant magnetoresistive sensors and high-moment magnetic nanoparticles demonstrates zeptomole sensitivity: potential for personalized medicine.
abstract: Zeptomole detector: A highly sensitive giant-magnetoresistive chip and FeCo nanoparticles can be used to linearly detect 600-4500 copies of streptavidin. Under unoptimized conditions, this system also detects human IL-6 with a sensitivity 13-times higher than that of standard ELISA techniques.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Balasubramanian
authors.initials: B
authors.lastname: Srinivasan
authors.forename: Yuanpeng
authors.initials: Y
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Jing
authors.forename: YunHao
authors.initials: Y
authors.lastname: Xu
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Yao
authors.forename: Chengguo
authors.initials: C
authors.lastname: Xing
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D001710:Biotin / Q000737:chemistry; D003035:Cobalt / Q000737:chemistry*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D007501:Iron / Q000737:chemistry*; D008280:Magnetics / Q000295:instrumentation / Q000379:methods*; D053768:Metal Nanoparticles / Q000737:chemistry*; D046529:Microscopy, Electron, Transmission; D040081:Protein Array Analysis; D015203:Reproducibility of Results; D019809:Streptavidin / Q000032:analysis
chemical_list: D015850:Interleukin-6; D003035:Cobalt; D001710:Biotin; D019809:Streptavidin; D007501:Iron