Successful desensitization by glargine administration in a patient with insulin allergy: a case report.
The patient was a 56-year-old man with type 2 diabetes and insulin allergy. He was administered glargine, which did not produce any allergic reactions, except for a small non-pruritic wheal. Thereafter, other insulin preparation could be administered. We consider this the first case of successful insulin desensitization by glargine administration.
Hara
Masumi
M
Department of Metabolic Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. masumihara-tky@umin.ac.jp
Izumida
Yoshihiko
Y
Sato
Nobuhiro
N
Ohashi
Ken
K
Osuga
Jun-ichi
J
Tobe
Kazuyuki
K
Tsukamoto
Kazuhisa
K
Kadowaki
Takashi
T
D003888:Desensitization, Immunologic / Q000379:methods*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000069036:Insulin Glargine; D007336:Insulin, Isophane / Q000009:adverse effects / Q000627:therapeutic use; D049528:Insulin, Long-Acting; D008297:Male; D008875:Middle Aged
D006442:Glycated Hemoglobin; D007328:Insulin; D000069036:Insulin Glargine; D007336:Insulin, Isophane; D049528:Insulin, Long-Acting