Cytotoxic phenanthroindolizidine alkaloids from the roots of Ficus septica.
Activity-monitored fractionation of the CHCl3 solubles of the MeOH extract of the roots of Ficus septica using cytotoxicity assay led to the isolation of twenty phenanthroindolizidine alkaloids, including ten new ficuseptines E-N and ten known compounds. The cytotoxic effects of some of the isolates were tested on gastric adenocarcinoma (NUGC) and nasopharyngeal carcinoma (HONE-1) cell lines and the results demonstrated that, with the exception of dehydrotylophorine, all the tested compounds displayed pronounced cytotoxic activity with significant cell growth inhibitory effects. In addition, 13a R-antofine was found to be highly effective with ED(50) values of < 0.1 microg/mL against L-1210, P-388, A-549 and HCT-8 cell lines in another assay.
Damu
Amooru G
AG
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan.
Kuo
Ping-Chung
PC
Shi
Li-Shian
LS
Li
Chia-Ying
CY
Su
Chung-Ren
CR
Wu
Tian-Shung
TS
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D030681:Ficus / Q000737:chemistry*; D006801:Humans; D018517:Plant Roots / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic