Trifunctional organocatalyst-promoted counterion catalysis for fast and enantioselective aza-Morita-Baylis-Hillman reactions at ambient temperature.
Fast and enantioselective aza-Morita-Baylis-Hillman reactions between electron-deficient or electron-rich aromatic N-tosyl imines and methyl vinyl ketone were achieved at ambient temperature using asymmetric counterion-directed catalysis promoted by trifunctional organocatalysts with a Brønsted base as the activity switch after protonation with benzoic acid.
Garnier
Jean-Marc
JM
Department of Chemistry & Biomolecular Sciences, Macquarie University, Sydney, NSW 2109, Australia.
Liu
Fei
F
D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019817:Benzoic Acid / Q000737:chemistry; D002384:Catalysis; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*; D011522:Protons; D013237:Stereoisomerism; D013696:Temperature
D001372:Aza Compounds; D007097:Imines; D007659:Ketones; D010636:Phenols; D010720:Phosphines; D011522:Protons; D019817:Benzoic Acid