Putting enterohemorrhagic E. coli on a pedestal.
Many pathogenic bacteria exploit host cytoskeletal pathways to promote infection. In this issue of Cell Host & Microbe, Weiss et al. (2009) identify the host factor IRSp53 as the missing link that connects two intracellular bacterial proteins, thereby completing an actin cytoskeletal signaling pathway critical to enterohemorrhagic Escherichia coli pathogenesis.
Yi
Chae-ryun
CR
Department of Medicine, Division of Infectious Diseases, Massachusetts General Hospital, Cambridge, MA 02139, USA.
Goldberg
Marcia B
MB
D054324:Enterohemorrhagic Escherichia coli / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions; D009419:Nerve Tissue Proteins / Q000378:metabolism*
C119539:BAIAP2 protein, human; D009419:Nerve Tissue Proteins