Polymorphisms of MMP-2 gene are associated with systolic heart failure risk in Han Chinese.
BACKGROUND
Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes responsible for protein degradation. MMP-2 has been demonstrated to play a pivotal role in myocardial remodeling process that occurs in congestive heart failure (HF). We hypothesized that MMP-2 genetic variations could be associated with systolic HF risk.


METHODS
To test the association of single nucleotide polymorphisms of MMP-2 with systolic HF risk, we performed a hospital-based, case-control study of 605 patients with systolic HF and 689 controls without HF. Three single nucleotide polymorphisms of MMP-2 (rs243864, rs243866, and rs17859821) were genotyped by restriction fragment length polymorphism methods.


RESULTS
The genotype frequencies of MMP-2 rs243866 AA and AG in the control group were significantly higher than that in the case group (24.7% versus 17.9%, P < 0.01). Compared with the GG homozygotes, MMP-2 rs243866 A allele carriers had a significantly lower risk of systolic HF (adjusted OR 0.69, 95% CI 0.49-0.98; P = 0.035). Haplotype analysis indicated the haplotype GGG (rs243864-rs17859821-rs243866) was associated with higher risk of systolic HF (adjusted OR 2.05, 95% CI 1.08-3.89; P = 0.028).


CONCLUSIONS
The findings of the current study suggest that MMP-2 rs243866 A allele was associated with lower risk of systolic HF in Han Chinese.
Hua
Yihong
Y
Department of Cardiology, Fu Wai Hospital, Beijing, China.
Song
Li
L
Wu
Naqiong
N
Lu
Xiangfeng
X
Meng
Xianmin
X
Gu
Dongfeng
D
Yang
Yuejin
Y
D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D002681:China; D005260:Female; D006333:Heart Failure / Q000208:ethnology* / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000235:genetics* / Q000502:physiology*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013599:Systole
D020778:Matrix Metalloproteinase 2