title: Pharmacist-driven aminoglycoside quality improvement program.
abstract: Our objective was to determine the impact of a pharmacist-driven aminoglycoside quality improvement program on the dosing methods of aminoglycosides at our institution. We assessed our current quality through retrospective review of all patients receiving aminoglycosides during a 5-month period. we then developed and implemented a pharmacist-driven aminoglycoside dosing program and prospectively assessed patients during a matched 5-month period. two hundred and sixteen patients were evaluated, 87 pre-program and 129 post-program. Prior to standardized pharmacist intervention, 44% of patients achieved optimal therapy. Oost implementation, patients achieving optimal therapy increased to 80% (p < 0.001). Patients in the pre-program group had a higher rate of acute changes in renal function compared to the post-program group (14.9% versus 6.2% [p <0.05]). This pharmacist-driven aminoglycoside dosing quality improvement program increased the frequency of optimal dosing of aminoglycosides and reduced the incidence of nephrotoxicity at our institution.
authors.affiliation: Brigham and Women's Hospital, Department of Pharmacy Services, Boston, MA 02115, USA. bgreenwood@partners.org
authors.forename: B C
authors.initials: BC
authors.lastname: Greenwood
authors.forename: P M
authors.initials: PM
authors.lastname: Szumita
authors.forename: C M
authors.initials: CM
authors.lastname: Lowry
mesh_terms: D000617:Aminoglycosides / Q000592:standards / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000592:standards / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D004363:Drug Utilization / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010595:Pharmacists / Q000592:standards*; D010607:Pharmacy Service, Hospital / Q000592:standards*; D011785:Quality Assurance, Health Care / Q000379:methods*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents