Anaphylaxis in patients with congenital bleeding disorders and inhibitors.
Anaphylactic reactions are rare emergencies observed in patients with inherited bleeding disorders. When these adverse events occur in patients with inhibitors, they further complicate the management of an already challenging clinical situation. Anaphylactoid inhibitors have been reported in patients with inhibitors associated with hemophilia A, hemophilia B, and type 3 von Willebrand disease. In this review, we summarize the current literature data on the occurrence of anaphylactoid reactions in patients with inherited bleeding disorders and alloantibodies. In particular, we focus on the pathophysiology of the inhibitor development and its management.
Franchini
Massimo
M
Immunohematology and Transfusion Center, Department of Pathology and Laboratory Medicine, University Hospital of Parma, Parma, Italy.
Lippi
Giuseppe
G
Montagnana
Martina
M
Targher
Giovanni
G
Zaffanello
Marco
M
Salvagno
Gian Luca
GL
Rivolta
Gianna Franca
GF
Di Perna
Caterina
C
Tagliaferri
Annarita
A
D000707:Anaphylaxis / Q000097:blood* / Q000209:etiology*; D025861:Blood Coagulation Disorders, Inherited / Q000097:blood* / Q000150:complications*; D019774:Blood Coagulation Factor Inhibitors / Q000097:blood*; D006801:Humans; D007518:Isoantibodies / Q000097:blood*
D019774:Blood Coagulation Factor Inhibitors; D007518:Isoantibodies