title: Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide.
abstract: Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.
authors.affiliation: Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA. yhoshino@uci.edu
authors.forename: Yu
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Takeo
authors.initials: T
authors.lastname: Urakami
authors.forename: Takashi
authors.initials: T
authors.lastname: Kodama
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koide
authors.forename: Naoto
authors.initials: N
authors.lastname: Oku
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Okahata
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Shea
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002614:Chelating Agents / Q000737:chemistry; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D006801:Humans; D008422:Materials Testing; D008555:Melitten / Q000737:chemistry* / Q000494:pharmacology*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011485:Protein Binding
chemical_list: D002614:Chelating Agents; D011108:Polymers; D008555:Melitten