title: Bone morphogenetic protein-7 and Gremlin: New emerging therapeutic targets for diabetic nephropathy.
abstract: Specific therapies of diabetic nephropathy (DN) are not available, and current treatment strategies are limited to management of blood glucose levels and control of hypertension. The re-activation of developmental programs in DN suggests new potential therapeutic targets. Bone morphogenetic protein-7 (BMP-7) and its antagonist, Gremlin is revealed to be involved in renal development and diabetic nephropathy. This article reviews the changes of BMP-7 and Gremlin in diabetic kidney, the protective effects on diabetic nephropathy when targeting BMP-7 and Gremlin, and the possible mechanism. The reorganization of the re-activation of Gremlin and BMP-7 in diabetic kidney had shed light on the identification of novel therapeutic targets for DN.
authors.affiliation: Department of Nephrology, Third Hospital, Hebei Medical University, Shijiazhuang, PR China. zhang2199@126.com
authors.forename: Yanling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qingxian
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000818:Animals; D055419:Bone Morphogenetic Protein 7 / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice
chemical_list: D055419:Bone Morphogenetic Protein 7; C486399:GREM1 protein, human; D036341:Intercellular Signaling Peptides and Proteins