title: Effect on histological and sperm kinetics in DBP exposed Wistar rats.
abstract: Di-n-butyl phthalate (DBP) is a ubiquitous environmental pollutant, extensively used as a softener for polyvinyl chloride resins. A study was conducted to evaluate its effect on reproductive function of Wistar rats. DBP was given orally at a dose of 500, 1000 and 1500 mg kg(-1) body weight for 7 days. Evaluating histological and fertility parameters assessed reproductive function. Significant reduction in seminiferous tubule diameter, Leydig cell nuclear diameter (except at dose 500 mg), number of primary spermatocytes, secondary spermatocytes and spermatids were observed. Caudal sperm density and viability reduced significantly. Decrease in serum testosterone was also observed. Evidence indicates that DBP exposure causes dose dependent testicular toxicity and has the potential to induce adverse effect.
authors.affiliation: Cell Biology Laboratory, Department of Zoology, University of Rajasthan, Jaipur-302 004, India. neenazoology@yahoo.co.in
authors.forename: Neena
authors.initials: N
authors.lastname: Nair
authors.forename: Sushila
authors.initials: S
authors.lastname: Bedwal
authors.forename: Deepa
authors.initials: D
authors.lastname: Kumari
authors.forename: Sunita
authors.initials: S
authors.lastname: Bedwal
authors.forename: R S
authors.initials: RS
authors.lastname: Bedwal
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D003993:Dibutyl Phthalate / Q000633:toxicity*; D005298:Fertility / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D007700:Kinetics; D007985:Leydig Cells / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D013094:Spermatozoa / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000473:pathology; D018675:Toxicity Tests
chemical_list: D003993:Dibutyl Phthalate