title: The feasibility of gene therapy in the treatment of head and neck cancer.
abstract: Standard approach to the treatment of head and neck cancer include surgery, chemotherapy, and radiation. More recently, dramatic increases in our knowledge of the molecular and genetic basis of cancer combined with advances in technology have resulted in novel molecular therapies for this disease. In particular, gene therapy, which involves the transfer of genetic material to cells to produce a therapeutic effect, has become a promising approach. Clinical trials concerning gene therapy strategies in head and neck cancer as well as combination of these strategies with chemotherapy and radiation therapy will be discussed.
authors.affiliation: Department of Clinical and Experimental Medicine, Section of Medical Oncology, University of Verona, Piazzale Stefani 1, 37126, Verona, Italy. manuelao@freemail.it
authors.forename: Emanuela
authors.initials: E
authors.lastname: Vattemi
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Claudio
mesh_terms: D000256:Adenoviridae / Q000235:genetics*; D017500:Adenovirus E1A Proteins / Q000008:administration & dosage / Q000235:genetics*; D002986:Clinical Trials as Topic; D005240:Feasibility Studies; D016158:Genes, p53; D015316:Genetic Therapy; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006801:Humans; D008081:Liposomes
chemical_list: D017500:Adenovirus E1A Proteins; D008081:Liposomes