title: ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas.
abstract: Cell adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) play an important role in glioma invasion and angiogenesis. The aim of this study was to investigate whether specific genetic polymorphisms of ICAM-1 and PECAM-1 could be associated with glioma development and progression. Single-nucleotide polymorphism in codon 469 of ICAM-1 and codon 125 of PECAM-1 were examined in 158 patients with astrocytomas and 162 controls using polymerase chain reaction and restriction enzyme analysis. The distribution of PECAM-1 polymorphic genotypes in astrocytomas did not show any significant difference. However, a specific ICAM-1 genotype (G/G, corresponding to Lys469Glu) exhibited higher frequency in grade II astrocytomas compared to controls, grade III, and grade IV astrocytomas; suggesting that this polymorphism could be involved in the development of grade II astrocytomas.
authors.affiliation: Department of Surgery and Anatomy, Faculty of Medicine of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, SP 14040-903, Brazil. rvburim@fcfrp.usp.br
authors.forename: Regislaine Valéria
authors.initials: RV
authors.lastname: Burim
authors.forename: Silvia Aparecida
authors.initials: SA
authors.lastname: Teixeira
authors.forename: Benedicto Oscar
authors.initials: BO
authors.lastname: Colli
authors.forename: Fernanda Maris
authors.initials: FM
authors.lastname: Peria
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Tirapelli
authors.forename: Suely Kazue Nagahashi
authors.initials: SK
authors.lastname: Marie
authors.forename: Suzana Maria Fleury
authors.initials: SM
authors.lastname: Malheiros
authors.forename: Sueli Mieko
authors.initials: SM
authors.lastname: Oba-Shinjo
authors.forename: Alberto Alain
authors.initials: AA
authors.lastname: Gabbai
authors.forename: Paulo Andrade
authors.initials: PA
authors.lastname: Lotufo
authors.forename: Carlos Gilberto
authors.initials: CG
authors.lastname: Carlotti-Júnior
mesh_terms: D001254:Astrocytoma / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D019408:Platelet Endothelial Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1