title: [Vaccination against yellow fever among patients on immunosuppressors with diagnoses of rheumatic diseases].
abstract: Yellow fever is endemic in some countries. The anti-yellow fever vaccine is the only effective means of protection but is contraindicated for immunocompromised patients. The aim of this paper was to report on a case series of rheumatological patients who were using immunosuppressors and were vaccinated against this disease. This was a retrospective study by means of a questionnaire applied to these patients, who were vaccinated 60 days before the investigation. Seventy patients of mean age 46 years were evaluated. Most of them were female (90%). There were cases of rheumatoid arthritis (54), systemic lupus erythematosus (11), spondyloarthropathy (5) and systemic sclerosis (2). The therapeutic schemes included methotrexate (42), corticosteroids (22), sulfasalazine (26), leflunomide (18), cyclophosphamide (3) and immunobiological agents (9). Sixteen patients (22.5%) reported some minor adverse effect. Among the eight patients using immunobiological agents, only one presented a mild adverse effect. Among these patients using immunosuppressors, adverse reactions were no more frequent than among immunocompetent individuals. This is the first study on this topic.
authors.affiliation: Serviço de Reumatologia, Hospital Universitário de Brasília, Universidade de Brasília, Brasília, DF. licia@unb.br
authors.forename: Licia Maria Henrique da
authors.initials: LM
authors.lastname: Mota
authors.forename: Ana Cristina Vanderley
authors.initials: AC
authors.lastname: Oliveira
authors.forename: Rodrigo Aires Corrêa
authors.initials: RA
authors.lastname: Lima
authors.forename: Leopoldo Luiz dos
authors.initials: LL
authors.lastname: Santos-Neto
authors.forename: Pedro Luiz
authors.initials: PL
authors.lastname: Tauil
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012216:Rheumatic Diseases / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D015004:Yellow Fever / Q000517:prevention & control*; D022341:Yellow Fever Vaccine / Q000009:adverse effects; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D022341:Yellow Fever Vaccine