title: Coordination of bismuth and lead in porphyrins: towards an in-situ generator for alpha-radiotherapy?
abstract: In order to investigate the possible coordination of both bismuth(III) and lead(II) by porphyrins for an application in alpha-radioimmunotherapy, several series of functionalized bismuth porphyrins have been synthesized and their stabilities in acidic medium were compared. Where unfunctionalized porphyrins are not suitable for such a purpose, strapped hanging carboxylate porphyrins are stable and allow a rapid coordination of both bismuth and lead. This property could lead to the preparation of an in-situ generator of alpha particles by a pre-complexation of (212)lead, the radioactive parent of (212)bismuth, in the ligand.
authors.affiliation: Université de Rennes1, Sciences Chimiques de Rennes, UMR CNRS 6226 (I.C.M.V.), 35042 Rennes Cedex, France.
authors.forename: Zakaria
authors.initials: Z
authors.lastname: Halime
authors.forename: Mohammed
authors.initials: M
authors.lastname: Lachkar
authors.forename: Bernard
authors.initials: B
authors.lastname: Boitrel
mesh_terms: D001729:Bismuth / Q000737:chemistry*; D007854:Lead / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D011166:Porphyrins / Q000737:chemistry*; D016499:Radioimmunotherapy / Q000379:methods*
chemical_list: D011166:Porphyrins; D007854:Lead; D001729:Bismuth