title: Direct catalytic asymmetric synthesis of highly functionalized 2-methylchroman-2,4-diols via Barbas-list aldol reaction.
abstract: A practical and sustainable chemical process for the synthesis of highly substituted aldol<-->lactol products was achieved for the first time through the asymmetric Barbas-List aldol (BLA) reaction of 2-hydroxybenzaldehydes with acetone in the presence of a catalytic amount of trans-4-OH-L-proline (see scheme).
authors.affiliation: School of Chemistry, University of Hyderabad, Hyderabad, India.
authors.forename: Dhevalapally B
authors.initials: DB
authors.lastname: Ramachary
authors.forename: Rajasekar
authors.initials: R
authors.lastname: Sakthidevi
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D002839:Chromans / Q000138:chemical synthesis* / Q000737:chemistry; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D002839:Chromans; D011392:Proline