DISC1 partners with GSK3beta in neurogenesis.
The protein DISC1, encoded by a gene implicated in schizophrenia susceptibility, regulates the development of postmitotic neurons. Mao et al. (2009) now report that DISC1 also regulates the proliferation of embryonic and adult neural progenitor cells through the GSK3beta/beta-catenin pathway, providing new insights into how susceptibility genes may contribute to the etiology of psychiatric disorders.
Ming
Guo-li
GL
Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. gming1@jhmi.edu
Song
Hongjun
H
D053687:Adult Stem Cells / Q000378:metabolism; D000818:Animals; D004622:Embryo, Mammalian / Q000166:cytology; D038362:Glycogen Synthase Kinase 3 / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D055495:Neurogenesis
C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3