Prognostic value of tumor-related molecular expression in gastric carcinoma.
In order to identify reliable molecular markers for prognostic prediction in gastric carcinoma, we evaluated the expression of six molecular markers, namely bFGF, IGF-2, HGF, MMP-9, integrin beta3 and uPA in gastric cancer. There was a significant correlation between the expression of these markers and the depth of tumor invasion, vessel invasion, lymph node and distant metastasis, TNM stage and microvessel density. The average survival time and 5-year survival rate of patients with positive expression of molecular markers was higher than those with negative expression. Multivariate analysis showed that abnormal expression of bFGF, MMP-9 and uPA, as well as depth of invasion, lymph node and distant metastasis and TNM stage were independently related to poor prognosis of gastric cancer. MMP-9, bFGF and uPA are potential candidates for development as clinically applicable molecular prognostic markers for gastric carcinoma, and may be effective therapeutic targets for the disease in the future.
Zhao
Zhong-Sheng
ZS
Department of Pathology, Zhejiang Provincal People's Hospital, 158 shangtang road, 310014, Hangzhou, China. lywyy1979@hotmail.com
Wang
Yuan-Yu
YY
Ye
Zai-Yuan
ZY
Tao
Hou-Quan
HQ
D000230:Adenocarcinoma / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D018279:Carcinoma, Signet Ring Cell / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D017228:Hepatocyte Growth Factor / Q000378:metabolism; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000378:metabolism; D039661:Integrin beta3 / Q000378:metabolism; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D008875:Middle Aged; D015999:Multivariate Analysis; D009389:Neovascularization, Pathologic; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*
D014408:Biomarkers, Tumor; D039661:Integrin beta3; D016222:Fibroblast Growth Factor 2; D017228:Hepatocyte Growth Factor; D007335:Insulin-Like Growth Factor II; D014568:Urokinase-Type Plasminogen Activator; D020780:Matrix Metalloproteinase 9