Induction system of neural and muscle lineage cells from bone marrow stromal cells; a new strategy for tissue reconstruction in degenerative diseases.
Since bone marrow stromal cells (MSCs) are easily accessible both from healthy donors and patients, and can be expanded on a therapeutic scale, they have attracted attention for cell-based therapy. MSCs contribute to the protection of host tissue after transplantation by Immune modulation and trophic effect. They also have an ability to differentiate into other cell kinds that will replenish lost cells in the degenerated tissue. This review discusses the potential of MSCs for tissue reconstruction in neuro- and muscle-degenerative diseases and their differentiation capacity into functional cells.
Kitada
Masaaki
M
Department of Stem Cell Biology and Histology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan.
Dezawa
Mari
M
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D004298:Dopamine / Q000096:biosynthesis; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000276:immunology; D032342:Muscle Cells / Q000166:cytology*; D020966:Muscular Disorders, Atrophic / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009416:Nerve Regeneration; D019636:Neurodegenerative Diseases / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D009474:Neurons / Q000166:cytology*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000628:therapy; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D020521:Stroke / Q000503:physiopathology / Q000628:therapy
D004298:Dopamine