title: Preparation and properties of macroporous brushite bone cements.
abstract: In the present work a macroporous brushite bone cement for use either as an injected or mouldable paste, or in the shape of preformed grafts, has been investigated. Macropores have been introduced by adding to the powder single crystals of mannitol which worked as a porogen. The size of the crystals was in the range of 250-500microm in diameter, suitable for cell infiltration, with a shape ratio between 3 and 6. From compression tests on cylindrical samples an elastic modulus in the range 2.5-4.2GPa and a compressive strength in the range 17.5-32.6MPa were obtained for a volume fraction of macropores varying between 15 and 0%. Thus the compressive strength exceeded in all tests the maximum value currently attributed to cancellous bone.
authors.affiliation: Department of Civil, Environmental and Architectural Engineering, University of Genova, Italy. giuseppe.cama@unige.it
authors.forename: G
authors.initials: G
authors.lastname: Cama
authors.forename: F
authors.initials: F
authors.lastname: Barberis
authors.forename: R
authors.initials: R
authors.lastname: Botter
authors.forename: P
authors.initials: P
authors.lastname: Cirillo
authors.forename: M
authors.initials: M
authors.lastname: Capurro
authors.forename: R
authors.initials: R
authors.lastname: Quarto
authors.forename: S
authors.initials: S
authors.lastname: Scaglione
authors.forename: E
authors.initials: E
authors.lastname: Finocchio
authors.forename: V
authors.initials: V
authors.lastname: Mussi
authors.forename: U
authors.initials: U
authors.lastname: Valbusa
mesh_terms: D000268:Adhesiveness; D000818:Animals; D001843:Bone Cements / Q000737:chemistry*; D002448:Cell Adhesion / Q000502:physiology; D002460:Cell Line; D019245:Compressive Strength; D055119:Elastic Modulus; D006244:Hardness; D008353:Mannitol / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology*; D016062:Porosity
chemical_list: D001843:Bone Cements; D008353:Mannitol