Recurrence of cryptococcal meningitis in HIV-infected patients following immune reconstitution.
Two HIV-infected patients had recurrent cryptococcal meningitis (CM) despite treatment with fluconazole and immune reconstitution with combination antiretroviral therapy (CART). Following treatment of CM with fluconazole, lumbar puncture should be performed either after completion of induction treatment for CM or before starting CART, in order to confirm cerebrospinal fluid sterility.
Seddon
J
J
Biomedical Research and Training Institute, Harare, Zimbabwe.
Mangeya
N
N
Miller
R F
RF
Corbett
E L
EL
Ferrand
R A
RA
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D017809:Fatal Outcome; D015725:Fluconazole / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000150:complications / Q000188:drug therapy*; D015497:HIV-1; D006801:Humans; D008297:Male; D016919:Meningitis, Cryptococcal / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D012008:Recurrence
D019380:Anti-HIV Agents; D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole