Endonasal versus supraorbital keyhole removal of craniopharyngiomas and tuberculum sellae meningiomas.
OBJECTIVE
Endonasal and supraorbital "eyebrow" craniotomies are increasingly being used to remove craniopharyngiomas and tuberculum sellae meningiomas. Herein, we assess the relative advantages, disadvantages, and selection criteria of these 2 keyhole approaches.


METHODS
All consecutive patients who had endonasal or supraorbital removal of a craniopharyngioma or tuberculum sellae meningioma were analyzed.


RESULTS
Of 43 patients, 22 had a craniopharyngioma (18 endonasal, 4 supraorbital), and 21 had a meningioma (12 endonasal, 7 supraorbital, 2 both routes); 33% had prior surgery. Craniopharyngiomas were primarily retrochiasmal in location in 78% of endonasal cases versus 25% of supraorbital cases (P = 0.08). Meningiomas were larger when approached by the supraorbital route versus the endonasal route (33 +/- 10 versus 25 +/- 8 mm, respectively; P = 0.008). Endoscopy was used in 84% of endonasal approaches and in 31% of supraorbital approaches (P = 0.001). Of patients having first-time surgery for a craniopharyngioma (n = 14) or meningioma (n = 15), total/near total removal was achieved in 83% and 80% of patients by the endonasal route and in 50% and 80% of patients by the supraorbital route, respectively. Vision improved in 87% and 70% of patients who had surgery by an endonasal versus supraorbital route, respectively (P = 0.3). Visual deterioration occurred in 2 patients with meningiomas, 1 by endonasal (7%), and 1 by supraorbital (11%) removal. The endonasal approach was associated with a higher rate of postoperative cerebrospinal fluid leaks (16 versus 0%; P = 0.3), 4 of 5 of which occurred in patients with meningioma.


CONCLUSIONS
The endonasal route is preferred for removal of most retrochiasmal craniopharyngiomas, whereas the supraorbital route is recommended for meningiomas larger than 30 to 35 mm or with growth beyond the supraclinoid carotid arteries. For smaller midline tumors, either approach can be used, depending on surgeon experience and tumor anatomy. Compared with traditional craniotomies, the major limitation of both approaches is a narrow surgical corridor. The endonasal approach has the added challenges of restricted lateral suprasellar access, a greater need for endoscopy, and a more demanding cranial base repair.
Fatemi
Nasrin
N
Brain Tumor Center, John Wayne Cancer Institute, Saint John's Health Center, Santa Monica, California 90404, USA.
Dusick
Joshua R
JR
de Paiva Neto
Manoel A
MA
Malkasian
Dennis
D
Kelly
Daniel F
DF
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D035301:Cranial Fossa, Middle / Q000473:pathology / Q000601:surgery; D003397:Craniopharyngioma / Q000473:pathology / Q000601:surgery*; D003399:Craniotomy / Q000295:instrumentation / Q000379:methods*; D004724:Endoscopy / Q000379:methods; D005260:Female; D005624:Frontal Bone / Q000033:anatomy & histology / Q000601:surgery; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000601:surgery*; D008579:Meningioma / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009296:Nasal Cavity / Q000033:anatomy & histology / Q000601:surgery; D019635:Neurosurgical Procedures / Q000295:instrumentation / Q000379:methods; D009915:Orbit / Q000033:anatomy & histology / Q000601:surgery; D010911:Pituitary Neoplasms / Q000473:pathology / Q000601:surgery*; D012658:Sella Turcica / Q000473:pathology / Q000601:surgery*; D019292:Skull Base Neoplasms / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome