[On pathogenetic significance of activation of lipid peroxidation in the mechanisms of disturbance of blood rheologic properties in experimental intoxication induced by fraction FII of vaccinal EV strain of Y. pestis].
Changes of blood viscosity were induced by parenteral administration of fraction II of vaccinal EV strain of Y. pestis ("murine" toxin) to mice at doses equivalent to LD50 and LD25. The study revealed correlation between lipid peroxidation activity, severity of autointoxication, and integrated indices of blood theologic properties.
Afanas'eva
G A
GA
Chesnokova
N P
NP
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D018056:Hemorheology / Q000187:drug effects / Q000502:physiology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D010930:Plague / Q000097:blood* / Q000382:microbiology; D010931:Plague Vaccine / Q000633:toxicity*; D014611:Vaccination / Q000009:adverse effects*; D015010:Yersinia pestis / Q000276:immunology* / Q000472:pathogenicity
D010931:Plague Vaccine