Thrombus resolution and vein wall injury: dependence on chemokines and leukocytes.
Chronic venous insufficiency resulting in post-thrombotic syndrome occurs commonly after acute deep vein thrombosis, and is a prevalent cause of vascular disease morbidity in the community. Therefore, a better understanding of the pathophysiologic mechanisms that promote the development of chronic venous insufficiency could lead to novel approaches to interrupt the natural history and prevent post-thrombotic syndrome. In this paper, we will review the evidence that venous thrombus resolution is an inflammatory process that is dependent on chemokines and leukocytes.
Henke
Peter K
PK
Department of Surgery, University of Michigan, USA. henke@umich.edu
Wakefield
Thomas
T
D054338:Cell Transdifferentiation; D018925:Chemokines / Q000378:metabolism*; D002908:Chronic Disease; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism; D054070:Postthrombotic Syndrome / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D013234:Stem Cells / Q000276:immunology; D013927:Thrombosis / Q000150:complications / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D014680:Veins / Q000276:immunology* / Q000473:pathology; D014689:Venous Insufficiency / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control
D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D020782:Matrix Metalloproteinases