New sesquiterpenes, JBIR-27 and -28, isolated from a tunicate-derived fungus, Penicillium sp. SS080624SCf1.
In the course of our screening program for novel metabolites from tunicate-derived fungi, novel sesquiterpenoids, named JBIR-27 (1) and -28 (2), together with known sporogen-AO1 and phomenone, were isolated from the culture broth of Penicillium sp. SS080624SCf1. The structures of 1 and 2 were determined to be eremophilane analogs on the basis of extensive NMR and MS analyses. Sporogen-AO1, phomenone and 2 showed cytotoxicity against human cervical carcinoma cell line HeLa at IC(50) values of 8.3, 19 and 92 microM, respectively, whereas 1 was inactive at a concentration of 80 microM.
Motohashi
Keiichiro
K
Biomedicinal Information Research Center, Japan Biological Informatics Consortium, Tokyo, Japan.
Hashimoto
Junko
J
Inaba
Shigeki
S
Khan
Shams Tabrez
ST
Komaki
Hisayuki
H
Nagai
Aya
A
Takagi
Motoki
M
Shin-ya
Kazuo
K
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D003470:Culture Media; D004271:DNA, Fungal / Q000096:biosynthesis / Q000378:metabolism; D005285:Fermentation; D006367:HeLa Cells; D006801:Humans; D013058:Mass Spectrometry; D008968:Molecular Conformation; D010407:Penicillium / Q000737:chemistry* / Q000378:metabolism*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D014561:Urochordata / Q000382:microbiology*
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D004271:DNA, Fungal; C544404:JBIR-27; C544405:JBIR-28; D012717:Sesquiterpenes