title: Two unusual cases of histoplasmosis in human immunodeficiency virus-infected individuals.
abstract: Histoplasmosis, also called as Darling's disease, is caused by the dimorphic fungus, Histoplasma capsulatum. In India, several cases of histoplasmosis have been reported since 1954, but in only a few cases could the diagnosis be confirmed by fungal culture. Disseminated histoplasmosis in adults is often associated with immunosuppression, as in human immunodeficiency virus (HIV) infection. Oral lesions are seen in 30-50% of the patients. Here, we are reporting two histoplasmosis cases, one with disseminated histoplasmosis with extensive skin and oral lesions in a known HIV-positive patient and the second case presenting with ulcer of the tongue, found to be HIV positive on investigation. It is important to consider histoplasmosis as one of the differential diagnosis of oral lesions in HIV-infected individuals.
authors.affiliation: Department of Skin and STD, Karnataka Institute of Medical Sciences, Hubli-580 022, Karnataka, India. sharadapbhagwat@yahoo.com
authors.forename: P V
authors.initials: PV
authors.lastname: Bhagwat
authors.forename: K
authors.initials: K
authors.lastname: Hanumanthayya
authors.forename: R S
authors.initials: RS
authors.lastname: Tophakhane
authors.forename: R M
authors.initials: RM
authors.lastname: Rathod
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006660:Histoplasmosis / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male
chemical_list: D044966:Anti-Retroviral Agents