title: Preterm birth prevention by 17 alpha-hydroxyprogesterone caproate vs. daily nursing surveillance.
abstract: OBJECTIVE
  To compare the incidence of spontaneous recurrent preterm delivery (SPTD) between women receiving 17 alpha-hydroxyprogesterone caproate (17P) and women receiving daily perinatal nursing surveillance (dPNS) with home uterine activity monitoring.
  
  
  METHODS
  Women enrolled for dPNS or weekly nursing visits with 17P injection were eligible. Included were singletons with previous SPTD, without preterm labor (PTL), cerclage or vaginal bleeding and < 27 weeks at enrollment. 17P and dPNS patients were matched 1:1 by race, marital status, tobacco use and number of SPTDs. Primary study outcome was incidence of spontaneous PTD.
  
  
  RESULTS
  Data from 342 matched pairs were compared. Diagnosis of PTL (39.2% vs. 60.8%) and tocolytic use (12.9% vs. 49.7%) was decreased with 17P vs. dPNS (p < 0.001). The incidences of spontaneous PTD at < 32, 35 and 37 weeks were similar between the groups.
  
  
  CONCLUSIONS
  There was no difference in recurrent SPTD between women treated with 17P and those receiving dPNS.
authors.affiliation: Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC 29425, USA.
authors.forename: Charles
authors.initials: C
authors.lastname: Rittenberg
authors.forename: Roger B
authors.initials: RB
authors.lastname: Newman
authors.forename: Niki B
authors.initials: NB
authors.lastname: Istwan
authors.forename: Debbie J
authors.initials: DJ
authors.lastname: Rhea
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Stanziano
mesh_terms: D000328:Adult; D005260:Female; D005866:Gestonorone Caproate / Q000008:administration & dosage*; D006699:Home Care Services; D006801:Humans; D007273:Injections, Intramuscular; D018670:Monitoring, Ambulatory; D007752:Obstetric Labor, Premature / Q000175:diagnosis* / Q000451:nursing / Q000517:prevention & control*; D011247:Pregnancy; D047928:Premature Birth / Q000517:prevention & control; D011372:Progestins / Q000008:administration & dosage*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D011372:Progestins; D005866:Gestonorone Caproate