title: Devastating ochronotic arthropathy with successful bilateral hip and knee arthroplasties.
abstract: Ochronotic arthropathy is a manifestation of long-standing alkaptonuria, a rare hereditary metabolic disorder characterized by the absence of the enzyme homogentisic acid oxidase. We describe a patient who developed rapidly progressive destructive ochronotic arthropathy in his knee and hip joints and underwent successful bilateral total knee and hip arthroplasties.
authors.affiliation: Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Araki
authors.forename: Akihiro
authors.initials: A
authors.lastname: Sudo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Atsumasa
authors.initials: A
authors.lastname: Uchida
mesh_terms: D000474:Alkaptonuria / Q000150:complications*; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D006801:Humans; D007592:Joint Diseases / Q000209:etiology / Q000473:pathology / Q000601:surgery; D007796:Laminectomy; D008297:Male; D008875:Middle Aged; D009794:Ochronosis / Q000150:complications* / Q000209:etiology; D013904:Thoracic Vertebrae / Q000473:pathology / Q000601:surgery