title: Clinical efficacy of 25% L-ascorbic acid (C'ensil) in the treatment of melasma.
abstract: BACKGROUND
  L-Ascorbic acid is used to treat melasma; however, it is quickly oxidized in aqueous solutions. Thus, C'ensil, a formulation containing 25% l-ascorbic acid and a chemical penetration enhancer, was created to promote the penetration of l-ascorbic acid into the skin.
  
  
  OBJECTIVE
  To evaluate the efficacy of C'ensil in patients with melasma.
  
  
  METHODS
  Forty subjects with melasma were treated with C'ensil during an open-label trial over a period of 16 weeks. Each subject's skin pigmentation was assessed every 4 weeks using the Melasma Area and Severity Index (MASI) and mexameter score. In addition, transepidermal water loss, skin dryness and irritation, and quality of life (Melasma Quality of Life Scale [MelasQoL]) were evaluated.
  
  
  RESULTS
  After 16 weeks, a significant decrease was noted in the degree of pigmentation based on the patients' MASI and mexameter scores. MelasQoL scores also decreased, indicating an increase in the subjects' quality of life.
  
  
  CONCLUSIONS
  Our data indicate that C'ensil is an effective treatment modality for melasma.
authors.affiliation: Department of Dermatology, Inje University School of Medicine, Busan, Korea.
authors.forename: Seon-Wook
authors.initials: SW
authors.lastname: Hwang
authors.forename: Doo-Jin
authors.initials: DJ
authors.lastname: Oh
authors.forename: Deborah
authors.initials: D
authors.lastname: Lee
authors.forename: Jung-Wook
authors.initials: JW
authors.lastname: Kim
authors.forename: Sung-Wook
authors.initials: SW
authors.lastname: Park
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008548:Melanosis / Q000188:drug therapy*; D008875:Middle Aged; D011760:Pyrrolidinones / Q000008:administration & dosage; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D004338:Drug Combinations; D011760:Pyrrolidinones; C038678:N-methylpyrrolidone; D001205:Ascorbic Acid