title: Age-related gray matter volume changes in the brain during non-elderly adulthood.
abstract: Previous magnetic resonance imaging (MRI) studies described consistent age-related gray matter (GM) reductions in the fronto-parietal neocortex, insula and cerebellum in elderly subjects, but not as frequently in limbic/paralimbic structures. However, it is unclear whether such features are already present during earlier stages of adulthood, and if age-related GM changes may follow non-linear patterns at such age range. This voxel-based morphometry study investigated the relationship between GM volumes and age specifically during non-elderly life (18-50 years) in 89 healthy individuals (48 males and 41 females). Voxelwise analyses showed significant (p<0.05, corrected) negative correlations in the right prefrontal cortex and left cerebellum, and positive correlations (indicating lack of GM loss) in the medial temporal region, cingulate gyrus, insula and temporal neocortex. Analyses using ROI masks showed that age-related dorsolateral prefrontal volume decrements followed non-linear patterns, and were less prominent in females compared to males at this age range. These findings further support for the notion of a heterogeneous and asynchronous pattern of age-related brain morphometric changes, with region-specific non-linear features.
authors.affiliation: Laboratory of Psychiatric Neuroimaging (LIM-21), Department of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil.
authors.forename: Débora
authors.initials: D
authors.lastname: Terribilli
authors.forename: Maristela S
authors.initials: MS
authors.lastname: Schaufelberger
authors.forename: Fábio L S
authors.initials: FL
authors.lastname: Duran
authors.forename: Marcus V
authors.initials: MV
authors.lastname: Zanetti
authors.forename: Pedro K
authors.initials: PK
authors.lastname: Curiati
authors.forename: Paulo R
authors.initials: PR
authors.lastname: Menezes
authors.forename: Márcia
authors.initials: M
authors.lastname: Scazufca
authors.forename: Edson
authors.initials: E
authors.lastname: Amaro
authors.forename: Cláudia C
authors.initials: CC
authors.lastname: Leite
authors.forename: Geraldo F
authors.initials: GF
authors.lastname: Busatto
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000375:Aging / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D018709:Statistics, Nonparametric; D055815:Young Adult