Variations in the neuropathology of familial Alzheimer's disease.
Mutations in the amyloid precursor protein (APP), presenilin 1 (PSEN1) and presenilin 2 (PSEN2) genes cause autosomal dominant familial Alzheimer's disease (AD). PSEN1 and PSEN2 are essential components of the gamma-secretase complex, which cleaves APP to affect Abeta processing. Disruptions in Abeta processing have been hypothesised to be the major cause of AD (the amyloid cascade hypothesis). These genetic cases exhibit all the classic hallmark pathologies of AD including neuritic plaques, neurofibrillary tangles (NFT), tissue atrophy, neuronal loss and inflammation, often in significantly enhanced quantities. In particular, these cases have average greater hippocampal atrophy and NFT, more significant cortical Abeta42 plaque deposition and more substantial inflammation. Enhanced cerebral Abeta40 angiopathy is a feature of many cases, but particularly those with APP mutations where it can be the dominant pathology. Additional frontotemporal neuronal loss in association with increased tau pathology appears unique to PSEN mutations, with mutations in exons 8 and 9 having enlarged cotton wool plaques throughout their cortex. The mechanisms driving these pathological differences in AD are discussed.
Shepherd
Claire
C
Prince of Wales Medical Research Institute, Barker Street, Randwick, NSW, 2031, Australia.
McCann
Heather
H
Halliday
Glenda Margaret
GM
D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001284:Atrophy; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D016923:Cell Death; D006801:Humans; D015213:Neuroimmunomodulation; D009474:Neurons / Q000473:pathology / Q000502:physiology; D010766:Phosphorylation; D058225:Plaque, Amyloid / Q000473:pathology; D053763:Presenilins / Q000235:genetics; D024801:Tauopathies / Q000235:genetics / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; C054369:MAPT protein, human; D053763:Presenilins; D016875:tau Proteins