title: Meta-analysis of the ACE gene polymorphism in cerebral infarction.
abstract: BACKGROUND
  The angiotensin-1 converting enzyme (ACE) gene is known to have two polymorphic alleles insertion/deletion (I/D). People with the DD genotype have been shown to be at greater risk of cerebral infarction, but only in some studies. Identification of cerebral infarction susceptibility genes and quantification of associated risks have been hampered by conflicting results from underpowered case-control studies. This meta-analysis was made to look specifically into the genetics of cerebral infarction among Han Chinese population.
  
  
  METHODS
  Genetic associations studies published from January 1, 1990 to December 30, 2007 were collected from databases of MEDLINE, EMBASE, CBM and CNKI. Data were extracted using standardised forms and pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated.
  
  
  RESULTS
  Twenty-nine original case-control studies of Han Chinese population, comprising 3654 patients with cerebral infarction and 3058 controls were included in the meta-analysis. Using the random effects model, the pooled ORs of ACE DD genotype VS ID+ II was 1.91 (95% CI 1.56 to 2.34, P<0.00001).
  
  
  CONCLUSIONS
  These data suggest that the ACE DD genotype may be a risk factor for cerebral infarction in Han Chinese population. A large scale case-control study is needed to clarify the functional effect of the polymorphism of the ACE I/D gene in the pathogenesis of cerebral infarction in Han Chinese population.
authors.affiliation: School of Medicine, Jinhua College of Profession and Technology, The People's Republic of China.
authors.forename: Hong-miao
authors.initials: HM
authors.lastname: Tao
authors.forename: Bei
authors.initials: B
authors.lastname: Shao
authors.forename: Guo-zhong
authors.initials: GZ
authors.lastname: Chen
mesh_terms: D044466:Asian People / Q000208:ethnology; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000453:epidemiology / Q000235:genetics*; D016208:Databases, Factual / Q000706:statistics & numerical data; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D013223:Statistics as Topic
chemical_list: D007703:Peptidyl-Dipeptidase A