title: Increasing accuracy of detection of breast cancer with 3-T MRI.
abstract: OBJECTIVE
  The purposes of this study were to assess the sensitivity and specificity of 3-T MRI compared with those of mammography and sonography in the evaluation of breast cancer and to evaluate the results in light of previously published data obtained with 1-T and 1.5-T systems.
  
  
  METHODS
  A retrospective review was conducted with data on 434 women (mean age, 53 years) who underwent MRI evaluation of the breasts (n = 868). Results obtained from 3-T MRI, mammographic, and sonographic examinations of all patients were compared. Sensitivity, specificity, and predictive values were calculated, and statistics were analyzed with the chi-square test.
  
  
  RESULTS
  The sensitivities of MRI, mammography, and sonography in the detection of malignancy were 100%, 81.8%, and 86.4%, and the specificities were 93.9%, 99%, and 98.1%. The specificity of MRI increased from 92.8% to 94.5% over the course of the study (2006-2007). Compared with mammography (p < 0.001) and sonography (p = 0.001), MRI depicted a significantly higher number of malignant tumors of the breast. There was no significant difference between mammography and sonography (p = 0.095). Results were compared with those in earlier reports in the literature.
  
  
  CONCLUSIONS
  MRI at 3 T is more sensitive than mammography and sonography in the detection of breast cancer and the characterization of small lesions (reaching 4 mm) but has lower specificity. Compared with the results of 1-T and 1.5-T MRI in the literature, 3-T MRI has higher sensitivity in the detection of breast cancer with no significant difference in specificity.
authors.affiliation: Radiology Department, University of Toledo Medical Center, 3000 Arlington Ave., Toledo, OH 43614-2598, USA. haitham.elsamaloty@utoledo.edu
authors.forename: Haitham
authors.initials: H
authors.lastname: Elsamaloty
authors.forename: Mohamed Salah
authors.initials: MS
authors.lastname: Elzawawi
authors.forename: Shaden
authors.initials: S
authors.lastname: Mohammad
authors.forename: Nabeel
authors.initials: N
authors.lastname: Herial
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016009:Chi-Square Distribution; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D008875:Middle Aged; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary