title: Evaluation of self-expandable, FK506-coated, covered stents in canine animal model.
abstract: This study aimed to evaluate whether drug coating of the recently developed covered SENDAI stents--self-expandable stents covered with segmented polyurethane (SPU) films--reduces neointimal thickening in animal model. FK506, which is one of the most effective immunosuppressants, was used. Bare stents; non-coated, covered stents; and FK506-coated, covered stents were placed bilaterally in the external iliac arteries of beagle dogs. After 1-month observation period, angiography did not show significant stent-induced stenosis. Histological evaluation revealed a completely endothelialized intravascular lumen and the absence of thrombus formation. The area of the intimal thickening induced by the FK506-coated stents was significantly smaller than that induced by the non-coated stents, whereas it was larger in the case of both the covered stents than that in the case of the bare stent. In conclusion, FK506 treatment of the self-expandable, covered stents was confirmed to effectively inhibit intimal thickening, although the SPU film used for covering functioned as a drug carrier in addition to a scaffold for intimal formation.
authors.affiliation: Department of Diagnostic Radiology, Graduate School of Medicine, Tohoku University, Sendai, Miyagi 980-8574, Japan.
authors.forename: Sachiko
authors.initials: S
authors.lastname: Sato
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Nakayama
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsuhashi
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Seiji
authors.forename: Kenichi
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Chiaki
authors.initials: C
authors.lastname: Takasawa
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ishibashi
authors.forename: Yue-Min
authors.initials: YM
authors.lastname: Zhou
authors.forename: Hatsue
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Asano
authors.forename: Shoki
authors.initials: S
authors.lastname: Takahashi
mesh_terms: D000792:Angiography / Q000379:methods; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004195:Disease Models, Animal; D004285:Dogs; D004337:Drug Carriers; D054855:Drug-Eluting Stents; D005260:Female; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007249:Inflammation; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry*; D016559:Tacrolimus / Q000008:administration & dosage*; D017539:Tunica Intima / Q000473:pathology
chemical_list: D020099:Coated Materials, Biocompatible; D004337:Drug Carriers; D007166:Immunosuppressive Agents; D011108:Polymers; D011140:Polyurethanes; D016559:Tacrolimus