title: Vitamin-d-receptor genotypes and bone-mineral density in postmenopausal women: interaction with physical activity.
abstract: The current study investigated the association between vitamin-D-receptor (VDR) genotypes with bone-mineral density (BMD) and its interaction with physical activity level (PAL). Individuals in a sample of 192 volunteers (67.84 +/- 5.23 years) underwent BMD evaluation and were genotyped for VDR ApaI, BsmI, FokI, and TaqI polymorphisms. Haplotypes were reconstructed through expectation-maximization algorithm, and regression-based haplotype-specific association tests were performed with studied phenotypes. None of the polymorphisms were associated with BMD at any site; however, haplotype was associated with femoral-neck and Ward's-triangle BMD. Interaction between PAL and VDR genotypes was significant for the FokI polymorphism at femoral-neck and Ward's-triangle BMD. The FokI T/T genotype was associated with higher BMD in active women. It was concluded that VDR haplotypes, but not genotypes, are associated with femoral-neck and Ward's-triangle BMD in postmenopausal women. Moreover, the results suggest that VDR FokI polymorphism might be a potential determinant of BMD response to physical activity.
authors.affiliation: Graduate Program in Physical Education, the College of Physical Education, University of Brasilia, Brazil.
authors.forename: Paulo
authors.initials: P
authors.lastname: Gentil
authors.forename: Tulio Cesar
authors.initials: TC
authors.lastname: de Lima Lins
authors.forename: Ricardo Moreno
authors.initials: RM
authors.lastname: Lima
authors.forename: Breno Silva
authors.initials: BS
authors.lastname: de Abreu
authors.forename: Dario
authors.initials: D
authors.lastname: Grattapaglia
authors.forename: Martim
authors.initials: M
authors.lastname: Bottaro
authors.forename: Ricardo Jaco
authors.initials: RJ
authors.lastname: de Oliveira
authors.forename: Rinaldo Wellerson
authors.initials: RW
authors.lastname: Pereira
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000704:Analysis of Variance; D015519:Bone Density / Q000235:genetics* / Q000502:physiology; D001938:Brazil; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D008159:Lumbar Vertebrae; D009043:Motor Activity / Q000235:genetics*; D011110:Polymorphism, Genetic; D017698:Postmenopause / Q000235:genetics* / Q000502:physiology; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D018167:Receptors, Calcitriol