title: Panax ginseng protects against global ischemia injury in rat hippocampus.
abstract: Based on the use of Panax ginseng C.A. Meyer (Family Araliaceae) for the treatment of stroke in traditional Korean medicine, the present study was carried out to evaluate neuroprotective effects of P. ginseng after transient global cerebral ischemia using the four-vessel occlusion rat model. Nissl staining, lipid peroxidation (malondialdehyde [MDA] formation), and activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx) of rat brain were assessed. Ethanolic P. ginseng extract (200 mg/kg, i.p.) significantly protected CA1 neurons against 10 minutes of transient forebrain ischemia as demonstrated by measuring the density of neuronal cells. P. ginseng also significantly decreased the level of MDA and increased the expression of GPx and SOD. These results suggest that P. ginseng might be neuroprotective against cerebral ischemia-induced injury in rat brain by decreasing lipid peroxides and increasing the expression of GPx and SOD.
authors.affiliation: Medicinal Crops Division, Ginseng & Medicinal Plants Research Institute, Rural Development Administration, Eumseong, Republic of Korea.
authors.forename: Young Ock
authors.initials: YO
authors.lastname: Kim
authors.forename: Hak-Jae
authors.initials: HJ
authors.lastname: Kim
authors.forename: Geum Soog
authors.initials: GS
authors.lastname: Kim
authors.forename: Ho Gi
authors.initials: HG
authors.lastname: Park
authors.forename: Sang Jong
authors.initials: SJ
authors.lastname: Lim
authors.forename: Nak Sul
authors.initials: NS
authors.lastname: Seong
authors.forename: Yung Woon
authors.initials: YW
authors.lastname: Ham
authors.forename: Sung Dong
authors.initials: SD
authors.lastname: Lee
authors.forename: Ki-Hyo
authors.initials: KH
authors.lastname: Jang
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Jung
authors.forename: Joo-Ho
authors.initials: JH
authors.lastname: Chung
authors.forename: Soon Ah
authors.initials: SA
authors.lastname: Kang
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects*; D002545:Brain Ischemia / Q000188:drug therapy*; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009474:Neurons / Q000187:drug effects*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D005894:Panax; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D010936:Plant Extracts; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase