title: Amyloid precursor protein secretases as therapeutic targets for traumatic brain injury.
abstract: Amyloid-beta (Abeta) peptides, found in Alzheimer's disease brain, accumulate rapidly after traumatic brain injury (TBI) in both humans and animals. Here we show that blocking either beta- or gamma-secretase, enzymes required for production of Abeta from amyloid precursor protein (APP), can ameliorate motor and cognitive deficits and reduce cell loss after experimental TBI in mice. Thus, APP secretases are promising targets for treatment of TBI.
authors.affiliation: Department of Neuroscience, Georgetown University Medical Center, Washington, DC, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Loane
authors.forename: Ana
authors.initials: A
authors.lastname: Pocivavsek
authors.forename: Charbel E-H
authors.initials: CE
authors.lastname: Moussa
authors.forename: Rachel
authors.initials: R
authors.lastname: Thompson
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Alan I
authors.initials: AI
authors.lastname: Faden
authors.forename: G William
authors.initials: GW
authors.lastname: Rebeck
authors.forename: Mark P
authors.initials: MP
authors.lastname: Burns
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000627:therapeutic use*; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000172:deficiency; D001930:Brain Injuries / Q000188:drug therapy* / Q000517:prevention & control; D003071:Cognition / Q000187:drug effects; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009043:Motor Activity / Q000187:drug effects
chemical_list: D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse