title: Carbohydrate recognition by boronolectins, small molecules, and lectins.
abstract: Carbohydrates are known to mediate a large number of biological and pathological events. Small and macromolecules capable of carbohydrate recognition have great potentials as research tools, diagnostics, vectors for targeted delivery of therapeutic and imaging agents, and therapeutic agents. However, this potential is far from being realized. One key issue is the difficulty in the development of "binders" capable of specific recognition of carbohydrates of biological relevance. This review discusses systematically the general approaches that are available in developing carbohydrate sensors and "binders/receptors," and their applications. The focus is on discoveries during the last 5 years.
authors.affiliation: Department of Chemistry and Center for Biotechnology and Drug Design, Georgia State University, Atlanta, Georgia 30302-4098, USA.
authors.forename: Shan
authors.initials: S
authors.lastname: Jin
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Cheng
authors.forename: Suazette
authors.initials: S
authors.lastname: Reid
authors.forename: Minyong
authors.initials: M
authors.lastname: Li
authors.forename: Binghe
authors.initials: B
authors.lastname: Wang
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000737:chemistry; D014408:Biomarkers, Tumor / Q000737:chemistry; D001897:Boronic Acids / Q000737:chemistry*; D002241:Carbohydrates / Q000737:chemistry*; D002417:Cattle; D045744:Cell Line, Tumor; D019040:E-Selectin / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D037102:Lectins / Q000737:chemistry*; D008024:Ligands; D051379:Mice; D011485:Protein Binding
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D001897:Boronic Acids; D002241:Carbohydrates; D019040:E-Selectin; D005456:Fluorescent Dyes; D037102:Lectins; D008024:Ligands