[The role of biology in the diagnosis of cerebrospinal fluid leaks].
Cerebrospinal fluid leakage is a rare but critical condition with a substantial risk of intracranial infection, therefore its diagnosis and treatment is of major importance. CSF leakage diagnostic can be a challenging problem. Nephelometric measurement of beta-trace protein in the liquorrhoea is a non-invasive and fast method that can be used for CSF leakage diagnosis. It should kept in mind, however, that the cut-off of 1.1 mg/L is not suitable for patients with bacterial meningitis and those with a reduced glomerular filtration rate. Complementary use of beta-trace protein assay and beta2-transferrin detection is therefore recommended.
Tabaouti
K
K
Laboratoire de biologie, Centre hospitalier Sainte-Anne, Paris, France. k.tabaouti@ch-sainte-anne.fr
Kraoul
L
L
Alyousef
L
L
Lahoud
G Abi
GA
Rousset
S Brovedani
SB
Lancelin
F
F
Mouchet
E
E
Piketty
M-L
ML
D002558:Cerebrospinal Fluid Otorrhea / Q000209:etiology; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology; D002560:Cerebrovascular Circulation; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000032:analysis*; D054834:Lipocalins / Q000032:analysis*; D008581:Meningitis / Q000209:etiology; D009391:Nephelometry and Turbidimetry; D015203:Reproducibility of Results; D013353:Subdural Effusion / Q000175:diagnosis* / Q000503:physiopathology; D014168:Transferrin / Q000378:metabolism
D054834:Lipocalins; D014168:Transferrin; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase