Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament.
Ca(2+) sensitizers are cardiotonic agents that directly increase the Ca(2+) sensitivity of cardiac myofilament. To find a novel Ca(2+) sensitizer, we have screened a group of phenolic compounds by examining their effects on the Ca(2+)-dependent force generation in cardiac muscle fibers. We found that propyl gallate, a strong antioxidant, increased the Ca(2+) sensitivity of cardiac myofilament in a dose-dependent and reversible manner. The present study indicates that propyl gallate is a novel type of Ca(2+) sensitizer with antioxidant activity, which might be more beneficial for the treatment of congestive heart failure associated with oxidative stress than existing Ca(2+) sensitizers.
Tadano
Naoto
N
Depertment of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan.
Morimoto
Sachio
S
Takahashi-Yanaga
Fumi
F
Miwa
Yoshikazu
Y
Ohtsuki
Iwao
I
Sasaguri
Toshiyuki
T
D008841:Actin Cytoskeleton / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011435:Propyl Gallate / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits
D000975:Antioxidants; D011435:Propyl Gallate; D002118:Calcium