The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia.
The Disrupted-in-Schizophrenia-1 (DISC1) polymorphism is a strong candidate for a schizophrenia-susceptibility gene as it is widely expressed in cortical and limbic regions, but the effect of its genotype variation on brain morphology in schizophrenia is not well known. This study examined the association between the DISC1 Ser704Cys polymorphism and volumetric measurements for a broad range of fronto-parietal, temporal, and limbic-paralimbic regions using magnetic resonance imaging in a Japanese sample of 33 schizophrenia patients and 29 healthy comparison subjects. The Cys carriers had significantly larger volumes of the medial superior frontal gyrus and short insular cortex than the Ser homozygotes only for healthy comparison subjects. The Cys carriers tended to have a smaller supramarginal gyrus than the Ser homozygotes in schizophrenia patients, but not in healthy comparison subjects. The right medial superior frontal gyrus volume was significantly correlated with daily dosage of antipsychotic medication in Ser homozygote schizophrenia patients. These different genotype effects of the DISC1 Ser704Cys polymorphism on the brain morphology in schizophrenia patients and healthy comparison subjects suggest that variation in the DISC1 gene might be, at least partly, involved in the neurobiology of schizophrenia. Our findings also suggest that the DISC1 genotype variation might have some relevance to the medication effect on brain morphology in schizophrenia.
Takahashi
Tsutomu
T
Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
Suzuki
Michio
M
Tsunoda
Masahiko
M
Maeno
Nobuhisa
N
Kawasaki
Yasuhiro
Y
Zhou
Shi-Yu
SY
Hagino
Hirofumi
H
Niu
Lisha
L
Tsuneki
Hiroshi
H
Kobayashi
Soushi
S
Sasaoka
Toshiyasu
T
Seto
Hikaru
H
Kurachi
Masayoshi
M
Ozaki
Norio
N
D000328:Adult; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D003545:Cysteine / Q000235:genetics; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009483:Neuropsychological Tests; D011110:Polymorphism, Genetic / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology*; D012565:Schizophrenic Psychology; D012694:Serine / Q000235:genetics
C412476:DISC1 protein, human; D009419:Nerve Tissue Proteins; D012694:Serine; D003545:Cysteine