Building molecular complexity via tandem Ru-catalyzed isomerization/C-H activation.
A tandem isomerization/C-H activation of allylic alcohols was performed using a catalytic amount of RuCl(2)(PPh(3))(3). A variety of ortho alkylated ketones have been obtained in excellent yields. This tandem process relies on an in situ generation of a carbonyl functional group that directs the ortho C-H bond activation.
Bartoszewicz
Agnieszka
A
Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
Martín-Matute
Belén
B