title: Biologically active components of a Papua New Guinea analgesic and anti-inflammatory lichen preparation.
abstract: A traditional preparation of Parmotrema saccatilobum (Taylor) Hale (Family: Parmeliaceae) is being considered for inclusion into the PNG national drug formulary by the Ministry of Health Taskforce on Traditional Medicines. The lichen preparation is traditionally used in the Milne Bay province of Papua New Guinea for analgesic and anti-inflammatory activities. A hexane extract of P. saccatilobum yielded the principle components atranorin and chloroatranorin. Atranorin and chloroatranorin were tested in a COX-1 and -2 enzyme inhibition assay, which showed that atranorin inhibited COX-1 in a dose dependent manner and suggests partial inhibition by atranorin and chloroatranorin of COX-2 and COX-1, respectively.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, UT 84112, USA.
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
authors.forename: Cynthia D
authors.initials: CD
authors.lastname: Andjelic
authors.forename: Ann R
authors.initials: AR
authors.lastname: Pole
authors.forename: Prem
authors.initials: P
authors.lastname: Rai
authors.forename: Chris M
authors.initials: CM
authors.lastname: Ireland
authors.forename: Louis R
authors.initials: LR
authors.lastname: Barrows
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005658:Fungi / Q000737:chemistry*; D062385:Hydroxybenzoates / Q000302:isolation & purification* / Q000494:pharmacology; D008011:Lichens / Q000737:chemistry*; D010219:Papua New Guinea; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D062385:Hydroxybenzoates; D010936:Plant Extracts; C543235:chloroatranorin; C026304:atranorin; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2