title: The effect of Echinacea purpurea (L.) Moench extract on experimental prostate hyperplasia.
abstract: The aim of this study was to examine the effect of purple coneflower (Echinacea purpurea L. Moench) on the prostate gland of rats using an experimental model of benign prostate hyperplasia (BPH). The animals were administered 50 mg/kg of extract preparation for 4 and 8 weeks and the prostate mass and structural degenerative changes were evaluated in the course of the experiment. The administration of E. purpurea extract to rats with hyperplasia for 4 and 8 weeks gradually and significantly reduced the prostate mass and reversed the degenerative changes in the structure of the prostate gland. The present investigation suggests extract of purple coneflower prevents the development of BPH.
authors.affiliation: Department of Physiology, Kaunas University of Medicine, Kaunas, Lithuania.
authors.forename: D
authors.initials: D
authors.lastname: Skaudickas
authors.forename: A J
authors.initials: AJ
authors.lastname: Kondrotas
authors.forename: E
authors.initials: E
authors.lastname: Kevelaitis
authors.forename: P R
authors.initials: PR
authors.lastname: Venskutonis
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D020900:Echinacea; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts