title: Pneumocystis jirovecii pneumonia in a baby with hyper-IgE syndrome.
abstract: A 4-month-old baby with a family history of hyper-IgE syndrome acquired Pneumocystis jirovecii pneumonia. The patient's hyper-IgE syndrome score was low, but a genetic study yielded a STAT3 mutation. P. jirovecii pneumonia can be added to the infections associated with hyper-IgE syndrome. In some cases, it may be the presenting manifestation of this immunodeficiency.
authors.affiliation: Department of Pediatrics B, Schneider Children's Medical Center of Israel, Petah Tiqwa 49202, Israel. gartyb@clalit.org.il
authors.forename: Ben Zion
authors.initials: BZ
authors.lastname: Garty
authors.forename: Adit
authors.initials: A
authors.lastname: Ben-Baruch
authors.forename: Asaf
authors.initials: A
authors.lastname: Rolinsky
authors.forename: Cristina
authors.initials: C
authors.lastname: Woellner
authors.forename: Bodo
authors.initials: B
authors.lastname: Grimbacher
authors.forename: Nufar
authors.initials: N
authors.lastname: Marcus
mesh_terms: D000907:Antibodies, Bacterial / Q000032:analysis; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D004269:DNA, Bacterial / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007223:Infant; D007589:Job Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D008297:Male; D045363:Pneumocystis carinii / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D013902:Radiography, Thoracic; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial; D007073:Immunoglobulin E