title: Demographics of pediatric-onset multiple sclerosis in an MS center population from the Northeastern United States.
abstract: BACKGROUND
  The prevalence of pediatric-onset multiple sclerosis (MS) in the United States is unknown.
  
  
  OBJECTIVE
  In a large cohort of MS patients, we sought to identify the proportion with first symptom-onset below the age of 18 years, and to compare their demographic and disease characteristics to a typical adult-onset MS population.
  
  
  METHODS
  Patients seen at the Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, Massachusetts, with clinical histories and characteristics of first symptoms recorded in an electronic database, were included in this study.
  
  
  RESULTS
  We found that 3.06% of patients with a recorded MS history experienced a first attack under the age of 18 years of age compared to 30.83% of patients who experienced first symptoms between the ages of 25-35 years. Gender proportions were similar in both groups, with the exception of a lower female preponderance in pre-pubertal-onset patients. There was a higher proportion of non-Caucasians in the younger cohort. Localization of first symptoms was similar in the two groups.
  
  
  CONCLUSIONS
  About 3% of MS patients experience their first symptom prior to the age of 18 years. Standardized follow-up is required after a first demyelinating attack in childhood, which may lead to earlier diagnosis and treatment of pediatric-onset MS.
authors.affiliation: Partners Pediatric Multiple Sclerosis Center, Massachusetts General Hospital for Children, Boston, MA, USA; Partners Multiple Sclerosis Center, Brigham and Women's Hospital, Boston, MA, USA. tchitnis@partners.org
authors.forename: T
authors.initials: T
authors.lastname: Chitnis
authors.forename: B
authors.initials: B
authors.lastname: Glanz
authors.forename: S
authors.initials: S
authors.lastname: Jaffin
authors.forename: B
authors.initials: B
authors.lastname: Healy
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D017677:Age Distribution; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D015331:Cohort Studies; D016208:Databases, Factual; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000208:ethnology*; D009511:New England / Q000453:epidemiology; D015995:Prevalence; D017678:Sex Distribution; D044465:White People / Q000706:statistics & numerical data; D055815:Young Adult