title: Thrombolytic therapy for management of complicated catheter-related Candida albicans thrombophlebitis.
abstract: In immunocompromised patients, endovascular infection due to Candida albicans is associated with significant morbidity and mortality. Recommended management includes removal of any existing central venous catheter. Rarely, complications of endocarditis or infected mural thrombi may arise, with poorer clinical outcomes. For large endoluminal lesions, particularly of the great vessels or those that are intra-atrial, thrombolysis has been used in paediatric populations or before surgery for dissolution of infected thrombus. We describe the case of an adult patient with lung carcinoma who developed persisting candidaemia with a large endovascular fungal lesion adherent to the tip of a peripherally inserted central venous catheter. Local urokinase infusion enabled safe removal of the catheter without embolization. As an adjunct to antifungal therapy, local thrombolysis may play a contributory role in the management of central venous catheter-related candidal septic thrombosis.
authors.affiliation: Department of Infectious Diseases, Dandenong Hospital, David Street, Dandenong, Victoria 3175, Australia. andrew.block@med.monash.edu.au
authors.forename: A A
authors.initials: AA
authors.lastname: Block
authors.forename: K A
authors.initials: KA
authors.lastname: Thursky
authors.forename: L J
authors.initials: LJ
authors.lastname: Worth
authors.forename: M A
authors.initials: MA
authors.lastname: Slavin
mesh_terms: D002177:Candidiasis / Q000188:drug therapy*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D016469:Fungemia / Q000150:complications; D006801:Humans; D016867:Immunocompromised Host; D008175:Lung Neoplasms / Q000150:complications; D008875:Middle Aged; D015912:Thrombolytic Therapy / Q000379:methods*; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D014568:Urokinase-Type Plasminogen Activator