Penicillamine-induced elastosis of the mucosal lip.
Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, "lumpy-bumpy"" or "bramble-bush"" morphologic changes of elastic fibers in the dermis are characteristic. Previous reports of these findings in normal-appearing skin and internal organs suggest a systemic elastolytic process. Here we report an unusual case of penicillamine-induced elastosis affecting the mucosa of the lip with characteristic histologic features.
Lewis
Bethany K H
BK
Department of Internal Medicine, University of Utah Hospitals and Clinics, Salt Lake City, Utah, USA.
Chern
Peggy L
PL
Stone
Mary Seabury
MS
D002614:Chelating Agents / Q000009:adverse effects*; D006801:Humans; D008047:Lip Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects*
D002614:Chelating Agents; D010396:Penicillamine