Fertility in female childhood cancer survivors.
Advances in childhood cancer treatment over the past decades have significantly improved survival, resulting in a rapidly enlarging group of childhood cancer survivors. There is much concern, however, about the effects of treatment on reproductive potential. In women there is evidence that both chemotherapy and radiotherapy may have an adverse effect on ovarian function, ovarian reserve and uterine function, clinically leading to sub-fertility, infertility, premature menopause and/or adverse pregnancy outcomes. Here we will first address normal female fertility and methods to detect decreased fertility. Hence we will focus on direct effects as well as late fertility-related adverse effects caused by chemotherapy and radiotherapy, and we will conclude with a summary of current options for fertility preservation in female childhood cancer survivors.
De Bruin
Marie L
ML
Van Dulmen-den Broeder
Eline
E
Van den Berg
Marleen H
MH
Lambalk
Cornelis B
CB
D000328:Adult; D000375:Aging / Q000502:physiology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D002648:Child; D005260:Female; D005298:Fertility / Q000502:physiology*; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control*; D008954:Models, Biological; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy*; D010053:Ovary / Q000502:physiology; D011309:Preservation, Biological / Q000379:methods; D011832:Radiation Injuries / Q000209:etiology / Q000503:physiopathology; D011878:Radiotherapy / Q000009:adverse effects; D017741:Survivors