title: Synthesis and biological evaluation of new enantiomerically pure azole derivatives as inhibitors of Mycobacterium tuberculosis.
abstract: A series of novel enantiomerically pure azole derivatives was synthesized. The new compounds, bearing both an imidazole as well as a triazole moiety, were evaluated as antimycobacterial agents. One of them proved to have activity against Mycobaterium tuberculosis comparable to those of the classical antibacterial/antifungal drugs Econazole and Clotrimazole.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, Siena, Italy.
authors.forename: Daniele
authors.initials: D
authors.lastname: Castagnolo
authors.forename: Marco
authors.initials: M
authors.lastname: Radi
authors.forename: Filippo
authors.initials: F
authors.lastname: Dessì
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Manetti
authors.forename: Manuela
authors.initials: M
authors.lastname: Saddi
authors.forename: Rita
authors.initials: R
authors.lastname: Meleddu
authors.forename: Alessandro
authors.initials: A
authors.lastname: De Logu
authors.forename: Maurizio
authors.initials: M
authors.lastname: Botta
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008826:Microbial Sensitivity Tests / Q000379:methods; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000254:growth & development*; D013237:Stereoisomerism
chemical_list: D000995:Antitubercular Agents; D001393:Azoles