title: Wavefront aberrations, depth of focus, and contrast sensitivity with aspheric and spherical intraocular lenses: fellow-eye study.
abstract: OBJECTIVE
  To compare wavefront aberration, depth of focus, contrast sensitivity, and in vivo modulation transfer function (MTF) after fellow-eye implantation of aspheric and spherical intraocular lenses (IOLs).
  
  
  METHODS
  Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom.
  
  
  METHODS
  This prospective randomized controlled study comprised patients with bilateral cataract who received an aspheric AcrySof SN60WF IOL or a spherical AcrySof SN60AT IOL in the first eye and the other IOL in the second eye. Assessments at 3 and 6 months included 100% and 9% logMAR best corrected visual acuity (BCVA) and photopic and mesopic functional acuity contrast testing. Total internal and corneal aberrations and depth of focus were computed. Distance-corrected near logMAR acuity was available at 12 months.
  
  
  RESULTS
  At 3 and 6 months, there was no significant difference in 100% and 9% BCVA or photopic contrast sensitivity. Mesopic contrast sensitivity was better and total and internal spherical aberrations were significantly less with the aspheric IOL. Total and internal eye vertical coma was reduced with aspheric IOL. Total MTF was not significantly different between groups. The aspheric IOL group had 0.46 diopter less depth of focus than the spherical IOL group at 6 months (P<.05). Distance-corrected near acuity was significantly better with the spherical IOL.
  
  
  CONCLUSIONS
  Aspheric IOLs significantly reduced spherical aberration, improving mesopic contrast sensitivity. Vertical coma was reduced with aspheric IOLs. Reduction of aberrations may be responsible for reduced depth of focus with aspheric IOLs. This may be disadvantageous for near vision and reading ability.
authors.affiliation: Department of Ophthalmology, St. Thomas' Hospital, London, United Kingdom.
authors.forename: Mayank A
authors.initials: MA
authors.lastname: Nanavaty
authors.forename: David J
authors.initials: DJ
authors.lastname: Spalton
authors.forename: James
authors.initials: J
authors.lastname: Boyce
authors.forename: Shouvik
authors.initials: S
authors.lastname: Saha
authors.forename: John
authors.initials: J
authors.lastname: Marshall
mesh_terms: D000368:Aged; D001699:Biometry; D015350:Contrast Sensitivity / Q000502:physiology*; D003867:Depth Perception / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008297:Male; D018918:Phacoemulsification; D011446:Prospective Studies; D019591:Pseudophakia / Q000503:physiopathology*; D012030:Refractive Errors / Q000503:physiopathology*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology