title: Clinical characteristics and outcome of Brucella endocarditis.
abstract: Brucella endocarditis, a rare complication of brucellosis, is the main cause of death attributable to this disease. There are difficulties in the diagnosis and uncertainty regarding many aspects of the treatment of Brucella endocarditis. We retrospectively examined the clinical characteristics and outcome of patients diagnosed with Brucella endocarditis. Of the six patients diagnosed as having Brucella endocarditis, four had valvular disease, one had aortic and mitral mechanic valve prosthesis (AVR+MVR) and one had secundum type atrial septal defect. Transesophageal echocardiography showed vegetations in four patients. Blood culture grew Brucella mellitensis only in two patients. Standard agglutination tests were elevated in all patients (range 1/320-1/10240). Four patients were managed with combined antibiotherapy and surgery. One refused further treatment and one refused an operation and follow-up was lost for that patient. Two patients died during follow-up; one having had a previous AVR+MVR operation refused further treatment and the other suffering renal failure. Due to the fulminant course of the disease, treatment should be initiated when there is a clinical suspicion, even if the culture results are unknown or negative. Agglutination titres aid in the diagnosis. A combination of antibiotherapy and surgery seems to be preferable treatment modality.
authors.affiliation: Department of Cardiology, Yuzuncu Yil University, Kazim Karabekir Street, Van 65100, Turkey. yilmazleman@yahoo.com
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Gunes
authors.forename: Mustafa
authors.initials: M
authors.lastname: Tuncer
authors.forename: Unal
authors.initials: U
authors.lastname: Guntekin
authors.forename: Serkan
authors.initials: S
authors.lastname: Akdag
authors.forename: Hasan
authors.initials: H
authors.lastname: Ali Gumrukcuoglu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Karahocagil
authors.forename: Hasan
authors.initials: H
authors.lastname: Ekim
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017347:Brucella melitensis / Q000302:isolation & purification*; D002006:Brucellosis / Q000000981:diagnostic imaging / Q000628:therapy*; D003131:Combined Modality Therapy; D004452:Echocardiography; D004697:Endocarditis, Bacterial / Q000000981:diagnostic imaging / Q000382:microbiology / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents