title: Efficient and systematic synthesis of a small glycoconjugate library having human complex type oligosaccharides.
abstract: To prepare a small library of homogeneous glycoconjugates with varying oligosaccharide structures, a combinatorial strategy was employed. The target glycopeptide was divided into two peptide segments (A and B) and both were prepared by solid phase peptide synthesis. These peptides, which can be coupled by native chemical ligation through an amide bond, were subsequently coupled to two kinds of human complex type oligosaccharides. This process systematically afforded the desired glycoconjugate library.
authors.affiliation: International Graduate School of Arts and Sciences, Yokohama City University, Yokohama, Kanagawa, Japan.
authors.forename: Takefumi
authors.initials: T
authors.lastname: Murase
authors.forename: Takashi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kajihara
mesh_terms: D002240:Carbohydrate Sequence; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry*
chemical_list: D006020:Glycopeptides; D009844:Oligosaccharides