title: A new USP Class VI-compliant substrate for manufacturing disposable microfluidic devices.
abstract: As microfluidic systems transition from research tools to disposable clinical-diagnostic devices, new substrate materials are needed to meet both the regulatory requirement as well as the economics of disposable devices. This paper introduces a UV-curable polyurethane-methacrylate (PUMA) substrate that has been qualified for medical use and meets all of the challenges of manufacturing microfluidic devices. PUMA is optically transparent, biocompatible, and exhibits high electroosmotic mobility without surface modification. We report two production processes that are compatible with the existing methods of rapid prototyping and present characterizations of the resultant PUMA microfluidic devices.
authors.affiliation: Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
authors.forename: Jason S
authors.initials: JS
authors.lastname: Kuo
authors.forename: Laiying
authors.initials: L
authors.lastname: Ng
authors.forename: Gloria S
authors.initials: GS
authors.lastname: Yen
authors.forename: Robert M
authors.initials: RM
authors.lastname: Lorenz
authors.forename: Perry G
authors.initials: PG
authors.lastname: Schiro
authors.forename: J Scott
authors.initials: JS
authors.lastname: Edgar
authors.forename: Yongxi
authors.initials: Y
authors.lastname: Zhao
authors.forename: David S W
authors.initials: DS
authors.lastname: Lim
authors.forename: Peter B
authors.initials: PB
authors.lastname: Allen
authors.forename: Gavin D M
authors.initials: GD
authors.lastname: Jeffries
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Chiu
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D003132:Commerce / Q000295:instrumentation*; D004867:Equipment Design / Q000295:instrumentation*; D008689:Methacrylates / Q000737:chemistry; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D044085:Microfluidics / Q000295:instrumentation*; D008855:Microscopy, Electron, Scanning; D010602:Pharmacopoeias as Topic / Q000592:standards*; D011140:Polyurethanes / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013379:Substrate Specificity; D013499:Surface Properties; D014481:United States
chemical_list: D001672:Biocompatible Materials; D008689:Methacrylates; D011140:Polyurethanes