Temporal evolution of intraocular pressure elevation after pupillary dilation in pigment dispersion syndrome.
OBJECTIVE
To report 4 patients with pigment dispersion syndrome (PDS) who had delayed intraocular pressure (IOP) spikes after pharmacologic pupillary dilation.


METHODS
Four patients with a diagnosis of PDS with documented IOP spike after pharmacologic pupillary dilation were included. Study patients were examined before and after pupillary dilation. The amount of pigment present in the anterior chamber and the IOP were measured at hourly intervals.


RESULTS
Although maximal pigment liberation occurred immediately after maximal dilation, the IOP continued to elevate for at least 1.5 hours.


CONCLUSIONS
The increase in IOP after pupillary dilation may not occur simultaneously with maximal pigment liberation but may follow it after the pigment has settled out of the anterior chamber. This has implications for monitoring patients with PDS after dilation to detect and treat rises in IOP.
Jewelewicz
Daniel A
DA
Department of Ophthalmology, Einhorn Clinical Research Center, New York Medical College, Valhalla, New York, USA.
Radcliffe
Nathan M
NM
Liebmann
Jeffrey
J
Ritch
Robert
R
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage; D000068438:Brimonidine Tartrate; D004338:Drug Combinations; D017889:Exfoliation Syndrome / Q000150:complications*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000009:adverse effects*; D009798:Ocular Hypertension / Q000139:chemically induced* / Q000188:drug therapy; D010656:Phenylephrine / Q000009:adverse effects; D011680:Pupil / Q000187:drug effects*; D011810:Quinoxalines / Q000008:administration & dosage; D012189:Retrospective Studies; D014065:Tonometry, Ocular; D014331:Tropicamide / Q000009:adverse effects
D000959:Antihypertensive Agents; D004338:Drug Combinations; D009184:Mydriatics; D011810:Quinoxalines; D010656:Phenylephrine; D000068438:Brimonidine Tartrate; D014331:Tropicamide