title: A study of the quantity of some stable and labile coagulation factors in fresh-frozen plasma produced from whole blood stored for 24 hours in Iran.
abstract: BACKGROUND
  The aim of this study was to assess whether the quantities of some coagulation factors in fresh-frozen plasma (FFP) produced from whole blood stored at 4 degrees C for 24 h are adequate for their intended purpose.
  
  
  METHODS
  The amounts of some coagulation factors (fibrinogen, FV, FVII, FVIII, FX and FXI) in FFP separated from whole blood after storage at 4 degrees C for 24 h were compared with the amounts of the corresponding coagulation factors in FFP separated from whole blood within 8 h of donation.
  
  
  RESULTS
  In 98% of the FFP units prepared after 24 h of storage, the levels of fibrinogen, FV, FVII, FX and FXI were greater than 0.5 IU/mL. The concentration of FVIII in the 24 h plasma units was 82% of that found in the FFP units prepared within 8 h of blood collection. In FFP, FVIII, FVII and FX were reduced by 38%, 8% and 3%, respectively, but FV, FXI and fibrinogen were not reduced.
  
  
  CONCLUSIONS
  These data suggest that there is good retention of coagulation factor activity in plasma produced from whole blood stored at 4 masculineC for 24 h and that such plasma would be an acceptable product for most patients requiring FFP.
authors.affiliation: Research Center, Iranian Blood Transfusion Organization, Tehran, Iran.
authors.forename: Hossin Timori
authors.initials: HT
authors.lastname: Naghadeh
authors.forename: Mehryar Habibi
authors.initials: MH
authors.lastname: Roudkenar
mesh_terms: D001779:Blood Coagulation Factors / Q000737:chemistry / Q000378:metabolism*; D001793:Blood Preservation; D003080:Cold Temperature; D006801:Humans; D007492:Iran; D010949:Plasma / Q000737:chemistry / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001779:Blood Coagulation Factors