Endometrial and cervical polyps in 22 baboons (Papio sp.), 5 cynomolgus macaques (Macaca fascicularis) and one marmoset (Callithrix jacchus).
BACKGROUND
Endometrial and cervical polyps are masses of endometrium or cervical epithelium that bulge into the uterine or cervical lumen. The physiopathology and contributing factors of endometrial polyps development are still unknown.


METHODS
Clinical and pathology records of 28 non-human primates with histologically confirmed endometrial and cervical polyps were reviewed. Twenty-one baboons with endometrial polyps were evaluated for age at diagnosis, body weight, menstrual cycle length, presence of endometriosis and adenomyosis and number of offspring, cesarean sections, and stillbirths.


RESULTS
Endometrial polyps in baboons were associated with increased age, decreased menstrual cycle lengths, endometriosis, and decreased parity. No differences were found for weight, adenomyosis, or number of cesarean sections or stillbirths.


CONCLUSIONS
Baboons are a promising model for the study of endometrial polyps because of their similarity to humans in both the development of endometrial polyps and association of many of the same risk factors.
Bennett
Melissa W
MW
Southwest National Primate Research Center at the Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.
Dick
Edward J
EJ
Schlabritz-Loutsevitch
Natalia E
NE
Lopez-Alvarenga
Juan C
JC
Williams
Priscilla C
PC
Sharp
R Mark
RM
Hubbard
Gene B
GB
D000818:Animals; D002144:Callithrix; D005260:Female; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000473:pathology*; D010215:Papio; D011127:Polyps / Q000473:pathology / Q000662:veterinary*; D002577:Uterine Cervical Diseases / Q000473:pathology / Q000662:veterinary*; D014591:Uterine Diseases / Q000473:pathology / Q000662:veterinary*