title: [Casein phosphopeptide--amorphous calcium phosphate (CPP-ACP) and its effect on dental hard tissues].
abstract: Dental products with casein phosphopeptide--amorphous calcium phosphate-nanocomplexes (CPP-ACP) are used in several tooth products (toothpastes, chewing gums, mouthrinses) and are as well used in dental filling material. CPP-ACP containing products are supposed to enhance remineralisation of dental hard tissues und thus might play a major role in prevention and therapy of initial caries or erosively dissolved enamel. Furthermore, also in hypersensitive teeth and even cases of hyposalivation, CPP-ACP containig products are supposed to improve the clinical condition. This article aims at three goals: point out the evolvement of CPP-ACP out of milk casein; description of possible biochemical effects of CPP-ACP on dental hard tissues; critical review of the current literature.
authors.affiliation: Klinik für Zahnerhaltung, Präventiv- und Kinderzahnmedizin Universität Bern. klaus.neuhaus@zmk.unibe.ch
authors.forename: Klaus W
authors.initials: KW
authors.lastname: Neuhaus
authors.forename: Adrian
authors.initials: A
authors.lastname: Lussi
mesh_terms: D000818:Animals; D002327:Cariostatic Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002364:Caseins / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D003731:Dental Caries / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects*; D003793:Dental Restoration, Permanent / Q000379:methods; D003804:Dentin / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000517:prevention & control; D004338:Drug Combinations; D005899:Glass Ionomer Cements; D006801:Humans; D008892:Milk; D008894:Milk Proteins / Q000737:chemistry; D016032:Randomized Controlled Trials as Topic; D014077:Tooth Erosion / Q000517:prevention & control; D014089:Tooth Remineralization; D014987:Xerostomia / Q000517:prevention & control
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; D004338:Drug Combinations; D005899:Glass Ionomer Cements; D008894:Milk Proteins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex