title: Neuropsychological assessment, neuroimaging, and neuropsychiatric evaluation in pediatric and adult patients with sickle cell disease (SCD).
abstract: Traditionally, neuropsychological deficits due to Sickle Cell Disease (SCD) have been understudied in adults. We have begun to suspect, however, that symptomatic and asymptomatic Cerebrovascular Events (CVE) may account for an alarming number of deficits in this population. In the current brief review, we critically evaluated the pediatric and adult literatures on the neurocognitive effects of SCD. We highlighted the studies that have been published on this topic and posit that early detection of CVE via neurocognitive testing, neuropsychiatric evaluations, and neuroimaging may significantly reduce adult cognitive and functional morbidities.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. cledwa00@acpub.duke.edu
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Edwards
authors.forename: Renee Dunn
authors.initials: RD
authors.lastname: Raynor
authors.forename: Miriam
authors.initials: M
authors.lastname: Feliu
authors.forename: Camela
authors.initials: C
authors.lastname: McDougald
authors.forename: Stephanie
authors.initials: S
authors.lastname: Johnson
authors.forename: Donald
authors.initials: D
authors.lastname: Schmechel
authors.forename: Mary
authors.initials: M
authors.lastname: Wood
authors.forename: Gary G
authors.initials: GG
authors.lastname: Bennett
authors.forename: Patrick
authors.initials: P
authors.lastname: Saurona
authors.forename: Melanie
authors.initials: M
authors.lastname: Bonner
authors.forename: Chante'
authors.initials: C
authors.lastname: Wellington
authors.forename: Laura M
authors.initials: LM
authors.lastname: DeCastro
authors.forename: Elaine
authors.initials: E
authors.lastname: Whitworth
authors.forename: Mary
authors.initials: M
authors.lastname: Abrams
authors.forename: Patrick
authors.initials: P
authors.lastname: Logue
authors.forename: Lekisha
authors.initials: L
authors.lastname: Edwards
authors.forename: Salutario
authors.initials: S
authors.lastname: Martinez
authors.forename: Keith E
authors.initials: KE
authors.lastname: Whitfield