title: Randomized, controlled, prospective trial of the use of a mesh to prevent parastomal hernia.
abstract: BACKGROUND
  The prevalence of terminal parastomal hernia (PH) after colostomy placement may be as high as 50%. The effect of the PH may range from discomfort to life-threatening complications. Surgical procedures for repairing PH are difficult to perform and present a high-failure rate.
  
  
  OBJECTIVE
  To reduce the incidence of PH by implanting a lightweight mesh in the sublay position.
  
  
  METHODS
  Randomized, controlled, prospective study. Patients were scheduled for permanent end colostomy surgery to treat cancer of the lower third of the rectum, performed by the same colorectal surgery team. An Ultrapro lightweight mesh was inserted in the sublay position in the study group. Using simple randomization, the sample size required was estimated to be 27 per group. Patients were followed-up clinically and radiologically with abdominal computed tomography by an independent clinician and a radiologist who were all blind to the aims of the study, 1 month and every 6 months after surgery.
  
  
  RESULTS
  : The groups were homogeneous in terms of their clinical and demographic characteristics. Surgical time and postoperative morbidity were similar in the 2 groups. Mortality was 0. No mesh intolerance was reported. In the clinical follow-up (median: 29 months, range: 13-49), 11/27 (40.7%) hernias were recorded in the control group compared with 4/27 (14.8%) in the study group (P = 0.03). Abdominal computed tomography identified 14/27 (44.4%) hernias in the control group compared with 6/27 (22.2%) in the study group (P = 0.08).
  
  
  CONCLUSIONS
  Parastomal placement of a mesh reduces the appearance of PH. The technique is safe, well-tolerated, and does not increase morbidity rates.
authors.affiliation: Servei de Cirurgia General i Aparell Digestiu, Corporació Sanitària Parc Taulí, Parc Taulí s/n, 08208 Sabadell, Barcelona, Spain. 22341jsa@comb.es
authors.forename: Xavier
authors.initials: X
authors.lastname: Serra-Aracil
authors.forename: Jordi
authors.initials: J
authors.lastname: Bombardo-Junca
authors.forename: Juan
authors.initials: J
authors.lastname: Moreno-Matias
authors.forename: Anna
authors.initials: A
authors.lastname: Darnell
authors.forename: Laura
authors.initials: L
authors.lastname: Mora-Lopez
authors.forename: Manuel
authors.initials: M
authors.lastname: Alcantara-Moral
authors.forename: Isidro
authors.initials: I
authors.lastname: Ayguavives-Garnica
authors.forename: Salvador
authors.initials: S
authors.lastname: Navarro-Soto
mesh_terms: D000368:Aged; D003125:Colostomy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D046449:Hernia, Abdominal / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D011336:Probability; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012016:Reference Values; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D013526:Surgical Mesh; D015996:Survival Rate; D013536:Suture Techniques; D013718:Tensile Strength; D016896:Treatment Outcome