Interleukin-1 gene cluster polymorphisms and gingival recessions after orthodontic treatment.
BACKGROUND
Genetic polymorphisms in the interleukin-1 gene cluster have been associated with the severity of periodontal diseases featured by a variable degree of destruction of connective tissue and bone, such as periodontitis and periimplantitis. This study was aimed to investigate if a link exists between such interleukin-1 gene polymorphisms and the development of gingival recessions during orthodontic treatment in Italian children.


METHODS
We evaluated, in 74 young Italian patients of both sexes, the -889 C/T polymorphism of the interleukin-1alpha gene and the -511 C/T and +3954 C/T polymorphisms of interleukin-1alpha gene by polymerase chain reactions-restriction fragment length polymorphism method using NcoI, AvaI and TaqI as restriction enzymes.


RESULTS
No association of interleukin-1 genotypes investigated and gingival recession occurring during orthodontic treatment were identified.


CONCLUSIONS
In the population studied specific interleukin-1 genotypes (linked to a higher susceptibility to bone resorption in periodontal disease) there does not appear to be any association with the development of gingival recessions during orthodontic treatment.
Bergandi
Loredana
L
Department of Genetics, Biology and Biochemistry, University of Torino, Italy.
Rubiano
Rachele
R
Brunazzo
Matteo
M
Aldieri
Elisabetta
E
Alfieri
Elisabetta
E
Dalmasso
Paola
P
Dal Masso
Paola
P
Cardaropoli
Giuseppe
G
Bracco
Pietro
P
Debernardi
Cesare
C
Ghigo
Dario
D
D000293:Adolescent; D002648:Child; D020022:Genetic Predisposition to Disease; D005889:Gingival Recession / Q000209:etiology / Q000235:genetics*; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D008297:Male; D008310:Malocclusion / Q000628:therapy; D005810:Multigene Family / Q000235:genetics; D009811:Odontometry; D011110:Polymorphism, Genetic; D014087:Tooth Movement Techniques / Q000009:adverse effects*
D053582:Interleukin-1alpha