A case of disseminated histoplasmosis following autologous stem cell transplantation for Hodgkin's lymphoma: an initial misdiagnosis with a false-positive serum galactomannan assay.
Systemic histoplasmosis is uncommonly reported in patients who have undergone bone marrow or solid organ transplantation. Diagnosis of systemic histoplasmosis in recipients of transplants may be hampered by lack of consideration of this infection in the differential diagnosis and may be confounded by conflicting information from other testing performed to evaluate for opportunistic infections in this population. We report successful treatment of a case of disseminated histoplasmosis in a patient with Hodgkin's lymphoma who had undergone autologous stem cell transplantation. The diagnosis was delayed by the finding of a positive serum galactomannan assay.
Jones
O
O
Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee 38104, USA.
Cleveland
K O
KO
Gelfand
M S
MS
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis*; D003951:Diagnostic Errors; D005189:False Positive Reactions; D005690:Galactose / Q000031:analogs & derivatives; D006658:Histoplasma / Q000145:classification / Q000302:isolation & purification; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008297:Male; D008351:Mannans / Q000097:blood*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014182:Transplantation, Autologous / Q000009:adverse effects; D016896:Treatment Outcome
D000935:Antifungal Agents; D008351:Mannans; C012990:galactomannan; D005690:Galactose