title: Let's think in alkaline phosphatase at heart function.
abstract: In their recent paper, Cheung et al [B.M. Cheung, K.L. Ong, L.Y. Wong, Elevated serum alkaline phosphatase and peripheral arterial disease in the United States National Health and Nutrition Examination Survey 1999-2004. Int J Cardiol 2008 (Electronic publication ahead of print)] described a significant association between serum alkaline phosphatase levels and low ankle-brachial blood pressure index, a risk factor for cardiovascular pathology. We had verified that alkaline phosphatase is present at the rat heart, showing a distribution compatible with cardiomyocyte sarcoplasmic reticulum. Moreover, several drugs with cardiac effect were shown to interfere with heart alkaline phosphatase activity. We therefore propose that alkaline phosphatase may be a local regulator at heart function and a putative target for therapeutic interventions.
authors.forename: Maria João
authors.initials: MJ
authors.lastname: Martins
authors.forename: Isabel
authors.initials: I
authors.lastname: Azevedo
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D006334:Heart Function Tests; D006801:Humans; D009206:Myocardium / Q000201:enzymology; D051381:Rats
chemical_list: D000469:Alkaline Phosphatase