title: Synthesis of azepino[4,5-b]indolones via an intermolecular radical oxidative substitution of N-Boc tryptamine.
abstract: A two-step protocol for the synthesis of azepino[4,5-b]indolone derivatives featuring a xanthate radical oxidative aromatic substitution on the N-Boc protected tryptamine, using dilauroyl peroxide (DLP) as initiator and oxidant, is described.
authors.affiliation: Instituto de Química, Universidad Nacional Autónoma de México, Circuito Exterior, Ciudad Universitaria, México, DF 04510, México.
authors.forename: Paul E
authors.initials: PE
authors.lastname: Reyes-Gutiérrez
authors.forename: Rubén O
authors.initials: RO
authors.lastname: Torres-Ochoa
authors.forename: Roberto
authors.initials: R
authors.lastname: Martínez
authors.forename: Luis D
authors.initials: LD
authors.lastname: Miranda
mesh_terms: D001381:Azepines / Q000138:chemical synthesis* / Q000737:chemistry; D005609:Free Radicals / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010545:Peroxides / Q000737:chemistry; D013237:Stereoisomerism; D014363:Tryptamines / Q000737:chemistry*; D014966:Xanthenes / Q000737:chemistry*
chemical_list: D001381:Azepines; D005609:Free Radicals; D007211:Indoles; D010545:Peroxides; D014363:Tryptamines; D014966:Xanthenes; C540210:azepino(4,5-b)indolone; C030820:tryptamine