title: Reverse seroconversion of hepatitis B virus after allogeneic hematopoietic stem cell transplantation in the absence of chronic graft-versus-host disease.
abstract: The appearance of hepatitis B surface antigen (HBsAg) in patients previously positive for antibody to this antigen (HBsAb) is called reverse seroconversion, a rare complication after hematopoietic stem cell transplantation (HSCT), which occurs almost exclusively after HSCT from an HBsAb-negative donor and the development of chronic graft-versus-host disease (CGVHD). However, we experienced a patient who developed reverse seroconversion 23 months after unrelated HSCT even in the absence of immunosuppressants use or CGVHD. Serum immunoglobulin level was persistently normal. Therefore, all HBsAb-positive recipients should be considered to be at risk for HBV reactivation, even in patients without any risk factors.
authors.affiliation: Division of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
authors.forename: Kumi
authors.initials: K
authors.lastname: Oshima
authors.forename: Miki
authors.initials: M
authors.lastname: Sato
authors.forename: Shinya
authors.initials: S
authors.lastname: Okuda
authors.forename: Kiriko
authors.initials: K
authors.lastname: Terasako
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakasone
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kako
authors.forename: Rie
authors.initials: R
authors.lastname: Yamazaki
authors.forename: Yukie
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Aki
authors.initials: A
authors.lastname: Tanihara
authors.forename: Takakazu
authors.initials: T
authors.lastname: Higuchi
authors.forename: Junji
authors.initials: J
authors.lastname: Nishida
authors.forename: Ikuo
authors.initials: I
authors.lastname: Nakamura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kanda
mesh_terms: D000328:Adult; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D006509:Hepatitis B / Q000097:blood / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens