[Hypoxia inducible factor-1alpha expression trends in hippocampus of rat of different ages].
OBJECTIVE
To reveal the expression trends of HIF-1alpha in hippocampus of different age rats, investigate the role of HIF-1alpha in the aging process of nervous system.


METHODS
The cerebral tissues was collectd from rats of different age, including 3, 18, 24, 36 months old. There were 6 rats in each age group. The expressions of nissl body and HIF-1alpha in different part of hippocampus were observed by nissl staining and immunohistochemical technique.


RESULTS
(1) With the increase of rat age, nerve cells appeared to be bigger and to arrange sparsely, while the nissl body decreased; (2) The positive HIF-1alpha staining cells in CA1, CA3 region of hippocampus increased along with the increase of rat age. The difference between any two age groups showed statistical significance (P < 0.05).


CONCLUSIONS
The function of protein synthesis weakened in nerve cells but the expression of HIF-1alpha increased with the age increasing, which may play an important role in aging of nervous system.
Wu
Hai-Qin
HQ
Department of Neurology, Second Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an 710004, China.
Wang
Hu-Qing
HQ
Guo
He-Na
HN
Zhang
Ru
R
Zhang
Gui-Lian
GL
D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D015870:Gene Expression; D006624:Hippocampus / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit