Synaptogenic proteins and synaptic organizers: "many hands make light work".
Synaptogenesis is thought to be mediated by cell adhesion proteins, which induce the initial contact between an axon and its target cell and subsequently recruit and organize the presynaptic and postsynaptic protein machinery required for synaptic transmission. A new study by Linhoff and colleagues in this issue of Neuron identifies adhesion proteins of the LRRTM family as novel synaptic organizers.
Brose
Nils
N
Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, Göttingen, Germany.
D000818:Animals; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D009419:Nerve Tissue Proteins