Palladium catalyzed tandem ring opening-ring closing reaction of diazabicyclic alkenes: a facile one pot strategy for cyclopentannulation of heterocycles.
A novel palladium catalyzed protocol for the synthesis of cyclopentene fused heterocycles from diazabicyclic alkenes and ortho-functionalized aryliodides has been elaborated. The reaction can be tuned toward the formation of either 3,4-disubstituted cyclopentenes or cyclopentene fused heterocycles by careful manipulation of the reaction parameters. A number of cyclopentene fused benzofurans and indole derivatives were prepared in excellent yield by utilizing the developed methodology.
John
Jubi
J
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR), Trivandrum 695 019, India.
Indu
U
U
Suresh
Eringathodi
E
Radhakrishnan
K V
KV