Applying translational research in understanding complications and defining targets for intervention: inflammation in PD as a model.
The bench-to-bedside approach to translational research is becoming increasingly important to efficiently advance understanding of the mechanisms underlying disease and to improve the quality of patient care. Although this investigation model has been practiced since the early days of the therapy, robust research platforms built to practice translational research have only recently been structured in the field of peritoneal dialysis. Experience with a translational research environment that generated most of the information cited in this overview is the core of this manuscript. The central investigation theme described is how to approach the cardiovascular complications of peritoneal dialysis. The research question was, could the continuous activation of inflammatory pathways be central in this process and represent a relevant target for interventions?
Pecoits-Filho
Roberto
R
Center for Health and Biological Sciences, Pontifícia Universidade Católica do Paraná, Curitiba, Brazil. r.pecoits@pucpr.br
D002318:Cardiovascular Diseases / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D012084:Renin-Angiotensin System / Q000502:physiology