Dynamics of T cell activation accompanying CD4 recovery in antiretroviral treated HIV-infected Ugandan children.
Africans have elevated T cell activation compared to residents of Europe or the USA. Levels of T cell activation also correlate with disease progression in HIV-infected individuals. We sought to determine if treatment with antiretroviral therapy (ART) would reduce levels of T cell activation (CD38 and HLADR co-expression) in HIV-infected Ugandan children. The median CD8+ T cell activation level among 199 ART-treated children (30%) was lower than in 57 ART-naïve children (45%, p<0.001), but remained higher than in 30 HIV-uninfected children (18%, p<0.001). Among ART-treated children, CD4% was inversely correlated with both CD8- (rho=-0.61, p<0.001) and CD8+ (rho=-0.38, p<0.001) T cell activation. Prospectively, CD4 recovery correlated with post-treatment CD8+ T cell activation level (p=0.008). Our data suggest that significant decreases in T cell activation accompany CD4 recovery in ART-treated HIV-infected African children, to levels that approach but do not reach those of uninfected children.
Ruel
Theodore
T
Department of Pediatrics, Division of Infectious Disease, University of California, San Francisco, San Francisco, CA 94143-0136, USA. ruelt@peds.ucsf.edu
Ssewanyana
Isaac
I
Achan
Jane
J
Gasasira
Anne
A
Kamya
Moses R
MR
Kekitiinwa
Adeodata
A
Wong
Joseph K
JK
Cao
Huyen
H
Havlir
Diane
D
Charlebois
Edwin D
ED
D051997:ADP-ribosyl Cyclase 1 / Q000276:immunology / Q000378:metabolism*; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation / Q000276:immunology*; D014454:Uganda
D019380:Anti-HIV Agents; D006684:HLA-DR Antigens; D051997:ADP-ribosyl Cyclase 1