Pediatric genitourinary tumors.
OBJECTIVE
We will review the 2007/2008 literature on pediatric genitourinary tumors.


RESULTS
Newly identified constitutional epigenetic defects in Wilms tumor genes extend the understanding of Wilms tumor risk in children lacking syndromic features, and add to the complexity of the pathogenesis of these tumor suppressor genes. Pediatric renal cell carcinoma has distinct molecular characteristics and clinical associations from the adult counterpart. The pathway from PAX3-FKHR translocation to the development of rhabdomyosarcoma tumors has been further elucidated.


CONCLUSIONS
Therapeutic strategies continue to be driven by developments in molecular diagnostics in pediatric genitourinary tumors.
Castellino
Sharon M
SM
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. scastell@wfubmc.edu
Martinez-Borges
Anibal R
AR
McLean
Thomas W
TW
D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D008297:Male; D012208:Rhabdomyosarcoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D014565:Urogenital Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D009396:Wilms Tumor / Q000175:diagnosis / Q000235:genetics / Q000628:therapy