Linoleic acid-menthyl ester reduces the secretion of apolipoprotein B100 in HepG2 cells.
The effect of linoleic acid-menthyl ester (LAME) on lipid metabolism were assessed in HepG2 cells. It is well known that high level of apolipoprotein (apo) B100 in the serum is risk for atherosclerosis. Although linoleic acid (LA) treatment and LA plus L-mentol treatment increased apo B100 secretion, LAME treatment significantly decreased apo B100 secretion in HepG2 cells compared with control medium. The hypolipidemic effect of LAME was attributable to the suppression of triglyceride synthesis in HepG2 cells. It is also known that the risk of coronary heart disease is negatively related to the concentration of serum apo A-1. In the present study, LAME treatment increased apo A-1 secretion as compared with LA treatment in HepG2 cells. These results suggest that mentyl-esterification of fatty acids may be beneficial in anti-atherogenic dietary therapy.
Inoue
Nao
N
Department of Applied Biochemistry and Food Science, Saga University, Saga, Japan.
Yamano
Naomi
N
Sakata
Kotaro
K
Arao
Keisuke
K
Kobayashi
Takashi
T
Nagao
Toshihiro
T
Shimada
Yuji
Y
Nagao
Koji
K
Yanagita
Teruyoshi
T
D016632:Apolipoprotein A-I / Q000378:metabolism; D053299:Apolipoprotein B-100 / Q000378:metabolism*; D045744:Cell Line, Tumor; D004952:Esters / Q000737:chemistry* / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D019787:Linoleic Acid / Q000737:chemistry*; D008745:Methylation; D012333:RNA, Messenger / Q000235:genetics; D014280:Triglycerides / Q000096:biosynthesis
D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D004952:Esters; D012333:RNA, Messenger; D014280:Triglycerides; D019787:Linoleic Acid