C(aryl)-O activation of aryl carboxylates in nickel-catalyzed biaryl syntheses.
Crucial breakthroughs in the activation of the C(aryl)-O bond of phenol derivatives were achieved almost simultaneously by two research groups (see scheme; Cy = cyclohexyl). Garg et al. coupled a range of aryl pivalates with arylboronic acids to give unsymmetrical biaryls. Shi et al. achieved this through C(aryl)-O activation of aryl carboxylates; the best results for the coupling of aryl boroxines were again obtained with aryl pivalates.
Goossen
Lukas J
LJ
FB Chemie-Organische Chemie, TU Kaiserslautern, Erwin-Schrödinger-Strasse Geb. 54, 67663 Kaiserslautern, Germany. goossen@chemie.uni-kl.de
Goossen
Käthe
K
Stanciu
Corneliu
C
D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D009532:Nickel / Q000737:chemistry*; D010421:Pentanoic Acids / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*
D001897:Boronic Acids; D010421:Pentanoic Acids; D010636:Phenols; D009532:Nickel; C005566:pivalic acid