title: C-arm CT measurement of cerebral blood volume: an experimental study in canines.
abstract: OBJECTIVE
  Cerebral blood volume (CBV) is an important parameter in estimating the viability of brain tissue following an ischemic event. We tested the hypothesis that C-arm CT measurements of CBV would correlate well with those made with perfusion CT (PCT).
  
  
  METHODS
  CBV was measured in 12 canines by using PCT and C-arm CT. Two measurements with each technique were made on each animal; a different injection protocol was used for each of these techniques. PCT was performed by using a 64-section V-scanner. C-arm CT was performed by using a biplane Artis dBA system. PCT images were transferred to a commercially available workstation for postprocessing and analysis; C-arm CT images were transferred to a commercially available workstation for postprocessing and analysis by using prototype software. From each animal, 2 sections from each technique were selected for analysis.
  
  
  RESULTS
  There was good agreement of both the color maps and absolute numbers between the 2 techniques. The maximum and mean deviations of values between the 2 techniques for the first 5 animals were 30.20% and 7.82%; for the second 7 animals, these values were 26.79% and 7.40%. The maximum and mean deviations between the 2 C-arm CT studies performed on the first 5 animals were 33.15% and 12.24%; for the second 7 animals, these values were 41.15% and 10.89%.
  
  
  CONCLUSIONS
  In these healthy animals, measurement of CBV with C-arm CT compared well with measurements made with PCT.
authors.affiliation: University of Wisconsin Hospitals and Clinics, Madison, Wis., USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Ahmed
authors.forename: M
authors.initials: M
authors.lastname: Zellerhoff
authors.forename: C M
authors.initials: CM
authors.lastname: Strother
authors.forename: K A
authors.initials: KA
authors.lastname: Pulfer
authors.forename: T
authors.initials: T
authors.lastname: Redel
authors.forename: Y
authors.initials: Y
authors.lastname: Deuerling-Zheng
authors.forename: K
authors.initials: K
authors.lastname: Royalty
authors.forename: D
authors.initials: D
authors.lastname: Consigny
authors.forename: D B
authors.initials: DB
authors.lastname: Niemann
mesh_terms: D000818:Animals; D001811:Blood Volume Determination / Q000379:methods*; D001921:Brain / Q000098:blood supply* / Q000502:physiology*; D002533:Cerebral Angiography / Q000379:methods*; D004285:Dogs; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*