title: Diffuse enteritis after colectomy for ulcerative colitis: two case reports and review of the literature.
abstract: Ulcerative colitis (UC) is an inflammatory disease of the colon. Involvement of the small bowel is limited to backwash ileitis or pouch-related conditions. Here, we report two men with UC who presented with small bowel inflammation and even perforation, within 1 month after subtotal colectomy. Endoscopy showed diffuse enteritis. Histology showed marked apoptosis of epithelial cells in both cases. One patient responded to steroids and the other to a calcineurin inhibitor. Both patients had no evidence of Crohn's disease in the small intestine before this event. Several more cases of small intestinal lesions in patients with well-established UC have been reported. The majority typically presented shortly after colectomy and responded well to steroids. The pathogenesis of this enteritis is unknown, but seems to be distinct from Crohn's disease and may be associated with UC and colectomy.
authors.affiliation: Department of Gastroenterology and Hepatology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. s.corporaal@int.umcg.nl
authors.forename: Sietske
authors.initials: S
authors.lastname: Corporaal
authors.forename: Arend
authors.initials: A
authors.lastname: Karrenbeld
authors.forename: Klaas
authors.initials: K
authors.lastname: van der Linde
authors.forename: Jan H
authors.initials: JH
authors.lastname: Voskuil
authors.forename: Jan H
authors.initials: JH
authors.lastname: Kleibeuker
authors.forename: Gerard
authors.initials: G
authors.lastname: Dijkstra
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D003082:Colectomy / Q000009:adverse effects*; D003093:Colitis, Ulcerative / Q000601:surgery*; D016099:Endoscopy, Gastrointestinal; D004751:Enteritis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D005938:Glucocorticoids