Total synthesis of ciguatoxin.
Something fishy: Ciguatoxin (see structure) is one of the principal toxins involved in ciguatera poisoning and the target of a total synthesis involving the coupling of three segments. The key transformations in this synthesis feature acetylene-dicobalthexacarbonyl complexation.
Hamajima
Akinari
A
Laboratory of Organic Chemistry, Bioagricultural Sciences, Nagoya University, Furocho, Chikusa 464-8601, Nagoya, Japan.
Isobe
Minoru
M
D000114:Acetylene / Q000737:chemistry; D002922:Ciguatoxins / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D007536:Isomerism
D002922:Ciguatoxins; D000114:Acetylene