title: The winged-helix transcription factor JUMU is a haplo-suppressor/triplo-enhancer of PEV in various tissues but exhibits reverse PEV effects in the brain of Drosophila melanogaster.
abstract: Gene expression goes along with changes in chromatin structure and is regulated by chromatin-modifying factors. If genes are transposed from their euchromatic position to the vicinity of heterochromatin, their expression can underly a position effect variegation (PEV). In Drosophila melanogaster a few genes are known that function in a gene dose-dependent manner as haplo-suppressors and triplo-enhancers of PEV or vice versa. The gene jumeaux (jumu) encodes a winged-helix transcription factor of multiple regulatory functions. A novel PEV test system for Drosophila melanogaster reveals that JUMU behaves as a haplo-suppressor/triplo-enhancer in different larval and adult tissues, but surprisingly behaves in the reverse manner as a haplo-enhancer/triplo-suppressor in larval and adult brains. Like jumu, the Su(var)3-9 gene also behaves as a haplo-suppressor/triplo-enhancer, but in our test system does not show any PEV effect in the brains.
authors.affiliation: Institut für Biologie-Genetik, Freie Universität Berlin, Arnimallee 7, 14195, Berlin, Germany.
authors.forename: Annemarie
authors.initials: A
authors.lastname: Hofmann
authors.forename: Madeleine
authors.initials: M
authors.lastname: Brünner
authors.forename: Günter
authors.initials: G
authors.lastname: Korge
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002843:Chromatin / Q000235:genetics; D055012:Chromosomal Position Effects / Q000235:genetics*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*; D001616:beta-Galactosidase
chemical_list: D002843:Chromatin; D029721:Drosophila Proteins; D012097:Repressor Proteins; C089148:Su(var)3-9 protein, Drosophila; D014157:Transcription Factors; C412163:jumu protein, Drosophila; D001616:beta-Galactosidase