title: Discovery of potent non-urea inhibitors of soluble epoxide hydrolase.
abstract: Soluble epoxide hydrolase (sEH) is a novel target for the treatment of hypertension and vascular inflammation. A new class of potent non-urea sEH inhibitors was identified via high throughput screening (HTS) and chemical modification. IC(50)s of the most potent compounds range from micromolar to low nanomolar.
authors.affiliation: Department of Medicine, Columbia University, New York, NY 10032, USA.
authors.forename: Yuli
authors.initials: Y
authors.lastname: Xie
authors.forename: Yidong
authors.initials: Y
authors.lastname: Liu
authors.forename: Gangli
authors.initials: G
authors.lastname: Gong
authors.forename: Deborah H
authors.initials: DH
authors.lastname: Smith
authors.forename: Fang
authors.initials: F
authors.lastname: Yan
authors.forename: Alison
authors.initials: A
authors.lastname: Rinderspacher
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: Zhu
authors.forename: Xiangpo
authors.initials: X
authors.lastname: Li
authors.forename: Shi-Xian
authors.initials: SX
authors.lastname: Deng
authors.forename: Lars
authors.initials: L
authors.lastname: Branden
authors.forename: Dusica
authors.initials: D
authors.lastname: Vidović
authors.forename: Caty
authors.initials: C
authors.lastname: Chung
authors.forename: Stephan
authors.initials: S
authors.lastname: Schürer
authors.forename: Christophe
authors.initials: C
authors.lastname: Morisseau
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Hammock
authors.forename: Donald W
authors.initials: DW
authors.lastname: Landry
mesh_terms: D055808:Drug Discovery / Q000379:methods*; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D012995:Solubility; D013329:Structure-Activity Relationship; D014508:Urea / Q000737:chemistry / Q000145:classification / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D014508:Urea; D004851:Epoxide Hydrolases