Isomer separation and gas-phase configurations of organoruthenium anticancer complexes: ion mobility mass spectrometry and modeling.
We have used ion mobility-mass spectrometry combined with molecular modeling for the separation and configurational analysis of three low-molecular-weight isomeric organoruthenium anticancer complexes containing ortho-, meta-, or para-terphenyl arene ligands. The isomers were separated using ion mobility based on traveling-wave technology and the experimentally determined collision cross sections were compared to theoretical calculations. Excellent agreement was observed between the experimentally and theoretically derived measurements.
Williams
Jonathan P
JP
Department of Chemistry, University of Warwick, Coventry, United Kingdom.
Bugarcic
Tijana
T
Habtemariam
Abraha
A
Giles
Kevin
K
Campuzano
Iain
I
Rodger
P Mark
PM
Sadler
Peter J
PJ
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D003198:Computer Simulation; D005740:Gases / Q000737:chemistry; D007536:Isomerism; D013058:Mass Spectrometry / Q000379:methods*; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry* / Q000302:isolation & purification; D012428:Ruthenium / Q000737:chemistry* / Q000302:isolation & purification; D013730:Terphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification
D000970:Antineoplastic Agents; D005740:Gases; D009942:Organometallic Compounds; D013730:Terphenyl Compounds; D012428:Ruthenium