Robustness and topology of the yeast cell cycle Boolean network.
Yeast cell cycle Boolean network was used as a case study of robustness to protein noise. Robustness was interpreted as involving stability of G1 steady state and sequence of gene expression from cell cycle START to stationary G1. A robustness measure to evaluate robustness strength of a network was proposed. Robust putative networks corresponding to the same steady state and sequence of gene expression of wild-type network were sampled. Architecture of wild-type yeast cell cycle network can be revealed by average topology profile of sampled robust putative networks.
Lee
Wen-Bin
WB
Department of Computer Science and Information Engineering, Chung Hua University, Hsin Chu 300, Taiwan, ROC.
Huang
Jiun-Yan
JY
D002453:Cell Cycle; D003198:Computer Simulation; D012441:Saccharomyces cerevisiae / Q000166:cytology* / Q000235:genetics / Q000378:metabolism*