Correlation amyloid in brain, kidney, and CSF of castrated guinea pigs.
OBJECTIVE
The association between low testosterone levels and Alzheimer's disease (AD) amyloid beta-peptide (Abeta) metabolism was investigated in brain and kidney of guinea pigs.


METHODS
The expression of Abeta peptide in the brain and kidney was assessed by using the immunohistochemistry method.


RESULTS
No expression of Abeta was seen in both groups of animals. This negative staining was found until the fourth week following castration. The formation of Abeta in guinea pigs is perhaps not a short duration process and may undergo different metabolic pathway compare to humans.


CONCLUSIONS
castration was not associated with the formation of Abeta in the brain and kidneys during a 1-month period and might require a longer period of time.
Wahjoepramonono
Eka J
EJ
Medical Faculty, Pelita Harapan University-Neuroscience Centre, Siloam Hospitals Lippo Karawaci, Tangerang, Indonesia. eka@siloamhospitals.com
Aniwiyanti
Vilia
V
Anggawidjaja
Suga T
ST
Yunianto
Yusuf
Irawan
I
D016229:Amyloid beta-Peptides / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009919:Orchiectomy; D013739:Testosterone / Q000378:metabolism / Q000502:physiology; D013997:Time Factors
D016229:Amyloid beta-Peptides; D013739:Testosterone