title: High Definition Oscillometry: a novel technique for non-invasive blood pressure monitoring in the cynomolgus monkey (Macaca fascicularis).
abstract: BACKGROUND
  Current approaches for accurate blood pressure determination rely predominantly on invasive techniques. High Definition Oscillometry (HDO) was evaluated as a potential non-invasive approach for accurate blood pressure recordings in cynomolgus monkeys.
  
  
  METHODS
  In conscious animals, systolic, diastolic, mean arterial blood pressure (MAP) and pulse/minute were determined 15 times within approx. 9 minutes per individual. This session was performed during 3 consecutive days. Anaesthesia induced hypotension was controlled simultaneously with HDO and telemetry as reference.
  
  
  RESULTS
  Repeated measurements were highly reproducible. After procedural habituation, mean MAP was 96.2 +/- 13.7 mmHg in males and 86.9 +/- 4.3 mmHg in females. Mean intraindividual coefficients of variation ranged between 10.8% and 2.4% depending on the session and parameter. Values determined by HDO corresponded to those reported for invasive techniques.
  
  
  CONCLUSIONS
  Our results demonstrate, using telemetry as reference, the accuracy of HDO-based non-invasive blood pressure measurements in macaques to detect drug-related cardiovascular changes.
authors.affiliation: Covance Laboratories GmbH, Muenster, Germany. barthel.schmelting@covance.com
authors.forename: B
authors.initials: B
authors.lastname: Schmelting
authors.forename: M
authors.initials: M
authors.lastname: Niehoff
authors.forename: B
authors.initials: B
authors.lastname: Egner
authors.forename: S H
authors.initials: SH
authors.lastname: Korte
authors.forename: G F
authors.initials: GF
authors.lastname: Weinbauer
mesh_terms: D000778:Anesthetics, Dissociative; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination; D005260:Female; D007649:Ketamine; D008252:Macaca fascicularis; D008297:Male; D009991:Oscillometry / Q000379:methods*; D013686:Telemetry / Q000379:methods*
chemical_list: D000778:Anesthetics, Dissociative; D007649:Ketamine