Design of synthetic polymer nanoparticles that capture and neutralize a toxic peptide.
Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.
Hoshino
Yu
Y
Department of Chemistry, University of California, Irvine, Irvine, CA 92697, USA. yhoshino@uci.edu
Urakami
Takeo
T
Kodama
Takashi
T
Koide
Hiroyuki
H
Oku
Naoto
N
Okahata
Yoshio
Y
Shea
Kenneth J
KJ
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002614:Chelating Agents / Q000737:chemistry; D004912:Erythrocytes / Q000166:cytology* / Q000187:drug effects*; D006801:Humans; D008422:Materials Testing; D008555:Melitten / Q000737:chemistry* / Q000494:pharmacology*; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011485:Protein Binding
D002614:Chelating Agents; D011108:Polymers; D008555:Melitten