Immunoreactivity of progesterone receptor isoform B, nuclear factor kappaB, and IkappaBalpha in adenomyosis.
Compared with normal endometrium, progesterone receptor isoform B (PR-B) and IkappaBalpha immunoreactivity were statistically significantly reduced in ectopic as well as eutopic endometrium from women with adenomyosis while nuclear p65, p50, and p52 immunoreactivity were statistically significantly increased in ectopic and eutopic endometrium. Nuclear p65 immunoreactivity was positively associated with heavier menses, and decreased PR-B and increased nuclear p65 immunoreactivity in ectopic endometrium were statistically significantly associated with the severity of dysmenorrhea in women with adenomyosis.
Nie
Jichan
J
Department of Gynecology, Shanghai OB/GYN Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, People's Republic of China.
Lu
Yuan
Y
Department of Gynecology, Shanghai OB/GYN Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, People's Republic of China.
Liu
Xishi
X
Department of Gynecology, Shanghai OB/GYN Hospital, and Department of Gynecology and Obstetrics, Shanghai Medical School, Fudan University, Shanghai, People's Republic of China.
Guo
Sun-Wei
SW
Renji Hospital, and the Institute of Obstetric and Gynecologic Research, Shanghai Jiao-Tong University School of Medicine, Shanghai, People's Republic of China. Electronic address: hoxa10@gmail.com.
D000328:Adult; D016022:Case-Control Studies; D002467:Cell Nucleus / Q000378:metabolism; D004412:Dysmenorrhea / Q000378:metabolism / Q000473:pathology; D004715:Endometriosis / Q000378:metabolism* / Q000473:pathology; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D020672:I-kappa B Proteins / Q000378:metabolism*; D008599:Menstruation Disturbances / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000378:metabolism*; D052002:NF-kappa B p50 Subunit / Q000378:metabolism; D052003:NF-kappa B p52 Subunit / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism*; D012720:Severity of Illness Index; D051996:Transcription Factor RelA / Q000378:metabolism
D020672:I-kappa B Proteins; D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D052003:NF-kappa B p52 Subunit; C000606204:NFKBIA protein, human; D011980:Receptors, Progesterone; D051996:Transcription Factor RelA; C097314:progesterone receptor B; D000072000:NF-KappaB Inhibitor alpha