title: Magnesium-based bone cement and bone void filler: preliminary experimental studies.
abstract: Bone cement has great potential in craniofacial surgery in the repair of osseous defects secondary to surgery or trauma. This includes the use of bone cement as a bone void filler for full-thickness cranial defects and as augmentation of deficient bones. Ideally, this material should be easily available, biocompatible, resorbable, bone inductive, and have adhesive qualities to bone. Calcium-based bone cements have some of these qualities but have a higher than desirable failure rate. OsteoCrete, a new magnesium-based bone cement and bone void filler, was compared to Norian in critical-sized skull defects and cementing bone flaps in rabbits. Both materials were successful; however, OsteoCrete had a faster resorption and replacement by bone rate than Norian. Bone flap position and apparent stability were also superior with OsteoCrete. There were no adverse reactions to either cement. A magnesium-based bone cement presents with advantages when compared with a comparator calcium-based cement in craniofacial surgery.
authors.affiliation: Division of Plastic Surgery, Stanford University Medical Center, Palo Alto, California 94304, USA. sschendel@stanford.edu
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Schendel
authors.forename: John
authors.initials: J
authors.lastname: Peauroi
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001843:Bone Cements / Q000627:therapeutic use*; D015519:Bone Density / Q000187:drug effects; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery; D001861:Bone Regeneration / Q000187:drug effects; D018786:Bone Substitutes / Q000627:therapeutic use*; D002130:Calcium Phosphates / Q000627:therapeutic use; D008274:Magnesium / Q000627:therapeutic use*; D017616:Magnesium Compounds / Q000627:therapeutic use*; D010012:Osteogenesis / Q000187:drug effects; D010710:Phosphates / Q000627:therapeutic use*; D011817:Rabbits; D012886:Skull / Q000473:pathology / Q000601:surgery; D013524:Surgical Flaps; D013997:Time Factors
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D017616:Magnesium Compounds; C496047:Norian SRS Cement; C542722:OsteoCrete; D010710:Phosphates; D008274:Magnesium