IL-17-producing gammadelta T cells.
IL-17 is produced not only by CD4(+) alphabeta T cells, but also CD8(+) alphabeta T cells, NKT cells, and gammadelta T cells, plus some non-T cells, including macrophages and neutrophils. The ability of IL-17 to deploy neutrophils to sites of inflammation imparts this cytokine with a key role in diseases of several types. Surprisingly, gammadelta T cells are responsible for much of the IL-17 produced in several disease models, particularly early on.
O'Brien
Rebecca L
RL
Integrated Department of Immunology, National Jewish Health, University of Colorado Denver, Denver, CO 80206, USA. obrienr@njhealth.org
Roark
Christina L
CL
Born
Willi K
WK
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism; D001419:Bacteria / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000378:metabolism; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D020381:Interleukin-17 / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology* / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology* / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016207:Cytokines; D020381:Interleukin-17; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta