title: Protection from radiation-induced pneumonitis using cerium oxide nanoparticles.
abstract: In an effort to combat the harmful effects of radiation exposure, we propose that rare-earth cerium oxide (CeO(2)) nanoparticles (free-radical scavengers) protect normal tissue from radiation-induced damage. Preliminary studies suggest that these nanoparticles may be a therapeutic regenerative nanomedicine that will scavenge reactive oxygen species, which are responsible for radiation-induced cell damage. The effectiveness of CeO(2) nanoparticles in radiation protection in murine models during high-dose radiation exposure is investigated, with the ultimate goal of offering a new approach to radiation protection, using nanotechnology. We show that CeO(2) nanoparticles are well tolerated by live animals, and they prevent the onset of radiation-induced pneumonitis when delivered to live animals exposed to high doses of radiation. In the end, these studies provide a tremendous potential for radioprotection and can lead to significant benefits for the preservation of human health and the quality of life for humans receiving radiation therapy.
authors.affiliation: Cancer Research Institute, M.D. Anderson Cancer Center Orlando, Orlando, Florida 32806, USA.
authors.forename: Jimmie
authors.initials: J
authors.lastname: Colon
authors.forename: Luis
authors.initials: L
authors.lastname: Herrera
authors.forename: Joshua
authors.initials: J
authors.lastname: Smith
authors.forename: Swanand
authors.initials: S
authors.lastname: Patil
authors.forename: Chris
authors.initials: C
authors.lastname: Komanski
authors.forename: Patrick
authors.initials: P
authors.lastname: Kupelian
authors.forename: Sudipta
authors.initials: S
authors.lastname: Seal
authors.forename: D Wayne
authors.initials: DW
authors.lastname: Jenkins
authors.forename: Cheryl H
authors.initials: CH
authors.lastname: Baker
mesh_terms: D000818:Animals; D002563:Cerium / Q000008:administration & dosage* / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000008:administration & dosage* / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D017564:Radiation Pneumonitis / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D011837:Radiation-Protective Agents; D017382:Reactive Oxygen Species; D002563:Cerium; C030583:ceric oxide