title: Evaluation of renal function in children with mitochondrial respiratory chain complex defect: usefulness of cystatin C.
abstract: OBJECTIVE
  Mitochondrial disorders with respiratory chain complex defect are known to show a broad spectrum of clinical phenotypes, though their contribution to renal disease has not received much attention. The aim of this study was to evaluate renal function using different markers of the glomerular filtration rate (GFR) in children with mitochondrial respiratory chain complex (MRC) defects.
  
  
  METHODS
  Twenty-two patients with MRC I defect confirmed by biochemical enzyme assays using muscle tissue, were evaluated for renal function with diethylenetriaminepentaacetic acid (DTPA) renal scintigraphy, urine creatinine clearance, serum creatinine (Scr) and cystatin C (Cys C) levels.
  
  
  RESULTS
  All patients showed lower levels within normal range of Scr (0.4-0.7 mg/dL, mean 0.47 mg/dL), and with no significant correlation with DTPA-GFR. Cys C showed significant correlation with DTPA-GFR (p < 0.01) providing higher diagnostic accuracy than creatinine in patients with MRC defect.
  
  
  CONCLUSIONS
  In mitochondrial disorder with MRC defect, Scr could not fully reflect renal function due to the relatively small body mass of patients. Considering the limited clinical availability of DTPA renal scintigraphy, Cys C should be taken as the first step to evaluate GFR in mitochondrial disorders.
authors.affiliation: Department of Pediatrics, Severance Children's Hospital, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Soon Min
authors.initials: SM
authors.lastname: Lee
authors.forename: Ji Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Mock
authors.initials: YM
authors.lastname: Lee
authors.forename: Joon Soo
authors.initials: JS
authors.lastname: Lee
authors.forename: Heung Dong
authors.initials: HD
authors.lastname: Kim
mesh_terms: D015415:Biomarkers / Q000097:blood* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood / Q000652:urine; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D028361:Mitochondrial Diseases / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D016284:Technetium Tc 99m Pentetate
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D019275:Radiopharmaceuticals; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate