title: Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients.
abstract: In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of epsilon2 allele and less frequent in the carriers of epsilon4 allele.
authors.affiliation: Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland. makaruk@ipin.edu.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Bednarska-Makaruk
authors.forename: Maria
authors.initials: M
authors.lastname: Rodo
authors.forename: Ałła
authors.initials: A
authors.lastname: Graban
authors.forename: Wanda
authors.initials: W
authors.lastname: Lojkowska
authors.forename: Anna
authors.initials: A
authors.lastname: Bochyńska
authors.forename: Danuta
authors.initials: D
authors.lastname: Ryglewicz
authors.forename: Hanna
authors.initials: H
authors.lastname: Wehr
mesh_terms: D053329:Apolipoprotein E2 / Q000097:blood / Q000235:genetics; D053318:Apolipoprotein E3 / Q000097:blood / Q000235:genetics; D053327:Apolipoprotein E4 / Q000097:blood / Q000235:genetics; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D001323:Autoantibodies / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003704:Dementia / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005838:Genotype; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
chemical_list: D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D001323:Autoantibodies; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D002784:Cholesterol