title: Misplacing objects in mild to moderate Alzheimer's disease: a descriptive analysis from the VISTA clinical trial.
abstract: BACKGROUND
  Misplacing objects is a commonly reported symptom of Alzheimer's disease (AD) but it is little described systematically and conflicting characterisations (losing/forgetting the location of objects versus inappropriate placement) of this "warning sign" of dementia currently exist. Patient and carer descriptions of misplacing in clinical interviews are reported here.
  
  
  METHODS
  This was a secondary qualitative analysis of video recorded, open ended and semistructured clinical interviews with 130 community dwelling patients with mild to moderate AD (mean age 77 (7.7) years; 63% women; 67% mild AD) and their carers who participated in the Video Imaging Synthesis of Treating Alzheimer's Disease (VISTA) study, a 4 month, randomised, placebo controlled trial of galantamine. Employing a framework analysis approach, we summarised descriptive accounts of misplacing with relevant proportions.
  
  
  RESULTS
  Recurrent incidents of misplacing were described for 96/130 (74%) study patients, 45 of whom established treatment goals to track this problem. For most (78/96, 81%), misplacing was the inability to recall where an item had been set down or put away. Fewer patients (25/96, including 18 with recall misplacing) put objects in unusual or incorrect places. Patients were commonly aware of their misplacing (56/96, 58%) and were distressed by it (31/56). Patients who misplaced also displayed tendencies towards delusions/hallucinations (51/96, but only directly related to misplacing in 17 cases) and hiding items (15%)
  
  
  CONCLUSIONS
  Misplacing is a common phenomenon in mild to moderate AD. Here, misplacing was usually described as an inability to recall where an item was set down, more so than the inappropriate placement of items.
authors.affiliation: Geriatric Medicine Research Unit, Capital District Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: L
authors.initials: L
authors.lastname: Hamilton
authors.forename: S
authors.initials: S
authors.lastname: Fay
authors.forename: K
authors.initials: K
authors.lastname: Rockwood
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy / Q000523:psychology*; D017028:Caregivers; D003627:Data Interpretation, Statistical; D004644:Emotions / Q000502:physiology; D005260:Female; D005702:Galantamine / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D009483:Neuropsychological Tests; D018697:Nootropic Agents / Q000627:therapeutic use; D016896:Treatment Outcome; D014743:Videotape Recording
chemical_list: D018697:Nootropic Agents; D005702:Galantamine