title: Comparison of experimental aneurysms embolized with second-generation embolic devices and platinum coils.
abstract: OBJECTIVE
  The purpose of the study was to compare the performance of second-generation embolic devices with that of platinum coils in experimental aneurysms.
  
  
  METHODS
  Microsurgically constructed bifurcation aneurysms in rabbits were embolized with platinum coils (n = 7), HydroCoils 10 (n = 10), HydroSoft (n = 14) or Cerecyte (n = 6) devices. After 1 month, angiographic occlusion was scored and the aneurysms were histologically evaluated by light microscopy. Continuous and ordinal results were compared using ANOVA/Tukey-Kramer HSD and chi(2) tests respectively.
  
  
  RESULTS
  Angiographic occlusion at follow-up was increased in the HydroCoil and HydroSoft groups and decreased in the platinum coil and Cerecyte groups. Fibrovascular tissue was observed in the sac of the Cerecyte group, while mixtures of fibrovascular tissue and fibrinous thrombus were observed in the other three groups. The inflammatory response and endothelialization of the neck were similar in all groups.
  
  
  CONCLUSIONS
  Expansile hydrogel devices have led to increased progressive occlusion, while degradable polymer devices led to an increased rate of thrombus organization compared with platinum coils.
authors.affiliation: Neuroscience Institut Salzburg/Department of Neurology, Christian Doppler Clinic/Paracelsus Medical University, Salzburg, Austria. m.killer@salk.at
authors.forename: Monika
authors.initials: M
authors.lastname: Killer
authors.forename: Thomas
authors.initials: T
authors.lastname: Hauser
authors.forename: Andrea
authors.initials: A
authors.lastname: Wenger
authors.forename: Bernd
authors.initials: B
authors.lastname: Richling
authors.forename: Gunther
authors.initials: G
authors.lastname: Ladurner
mesh_terms: D000818:Animals; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic / Q000295:instrumentation*; D005260:Female; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008297:Male; D008866:Microsurgery; D010984:Platinum; D011817:Rabbits; D016896:Treatment Outcome
chemical_list: D010984:Platinum