title: Rhinosinusitis in children and asthma severity.
abstract: OBJECTIVE
  Rhinosinusitis is a common condition in children. The association between rhinosinusitis and asthma is supported by strong epidemiological and pathogenic evidence. Moreover, a close relationship between sinusitis and asthma severity has also been reported. This study shows the new findings in this strong relationship.
  
  
  RESULTS
  The profile of inflammatory cells and inflammatory mediators seen in both conditions bears considerable similarity, especially in both diseases with a relevant role played by eosinophils.
  
  
  CONCLUSIONS
  Severe asthma is uncommon in childhood, but there is compelling evidence showing that the most severe asthma is closely associated to upper respiratory illness, especially rhinosinusitis. Treatment of chronic rhinosinusitis, medical or surgical or both, benefits concomitant asthma and has been shown to reduce the severity of asthma.
authors.affiliation: Department of Otolaryngology, Nippon Medical School, Tokyo, Japan.
authors.forename: Ruby
authors.initials: R
authors.lastname: Pawankar
authors.forename: Mario E
authors.initials: ME
authors.lastname: Zernotti
mesh_terms: D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001249:Asthma / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D002465:Cell Movement; D049109:Cell Proliferation; D002648:Child; D019818:Clavulanic Acid / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004804:Eosinophils / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D012220:Rhinitis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D012852:Sinusitis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D000658:Amoxicillin