[Efficacy of polyglycosides of Tripterygium wilfordii in preventing postoperative recurrence of Crohn disease].
OBJECTIVE
To observe the efficacy of polyglycoside of Tripterygium wilfordii(GTW) in preventing postoperative recurrence of Crohn disease(CD).


METHODS
Thirty-nine post-operative CD patients in whom all of the diseased gut had been removed from January 2005 to December 2006 were enrolled in a randomized, placebo-controlled trial. The patients took GTW(21 cases) or SASP(18 cases) in two weeks after operation. Crohn disease activity index(CDAI), ESR and CRP were collected at week 0, 13, 26, 52 or at the onset of symptoms. Ileocolonoscopy was performed at the end of the trial or at the onset of symptoms.


RESULTS
One patient in GTW group and 2 patients in SASP group were lost and 2 patients in GTW were excluded from the trial for non-compliance. Clinical recurrence was ascertained in one patient (5.6%) received GTW and in four (25.0%) received SASP. Four of eighteen patients in GTW(22.2%) had endoscopic recurrence compared with nine of sixteen(56.2%) in SASP. There were significant differences between the two groups(P<0.05).


CONCLUSIONS
Tripterygium wilfordii showed good efficacy in preventing recurrence of postoperative CD which can maintain remission and prevent recurrence.
Liao
Nan-sheng
NS
Department of General Surgery, Jinling Hospital, Clinical School of Medical College of Nanjing University, Nanjing 210002, China. .
Ren
Jian-an
JA
Fan
Chao-gang
CG
Wang
Ge-fei
GF
Zhao
Yun-zhao
YZ
Li
Jie-shou
JS
D000328:Adult; D003424:Crohn Disease / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006027:Glycosides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D011184:Postoperative Period; D055502:Secondary Prevention; D016896:Treatment Outcome; D029757:Tripterygium
D004365:Drugs, Chinese Herbal; D006027:Glycosides