Composite S-layer lipid structures.
Designing and utilization of biomimetic membrane systems generated by bottom-up processes is a rapidly growing scientific and engineering field. Elucidation of the supramolecular construction principle of archaeal cell envelopes composed of S-layer stabilized lipid membranes led to new strategies for generating highly stable functional lipid membranes at meso- and macroscopic scale. In this review, we provide a state of the art survey how S-layer proteins, lipids, and polysaccharides may be used as basic building blocks for the assembly of S-layer supported lipid membranes. These biomimetic membrane systems are distinguished by a nanopatterned fluidity, enhanced stability and longevity and thus, provide a dedicated reconstitution matrix for membrane-active peptides and transmembrane proteins. Exciting areas for application of composite S-layer membrane systems concern sensor systems involving specific membrane functions.
Schuster
Bernhard
B
Department für NanoBiotechnologie, Universität für Bodenkultur Wien, Vienna, Austria. bernhard.schuster@boku.ac.at
Sleytr
Uwe B
UB
D032701:Biomimetics; D008562:Membrane Glycoproteins / Q000737:chemistry; D008563:Membrane Lipids / Q000737:chemistry*; D036103:Nanotechnology
D008562:Membrane Glycoproteins; D008563:Membrane Lipids; C055764:S-layer proteins