The role of HER2 in metastatic breast cancer treated with a combination of taxanes and cisplatin.
BACKGROUND
A combination of taxanes and cisplatin have shown modest activity as second-line chemotherapy in breast cancer patients who have been exposed to anthracyclines. The purpose of this study was to retrospectively assess whether HER2 is associated with clinical sensitivity or with prognostic significance in breast cancer patient groups who had received chemotherapy with taxanes and cisplatin.


METHODS
Patients were treated either with docetaxel 60 mg/m square or paclitaxel 175 mg/m square in combination with cisplatin 50 mg/m/every 3 weeks. The tumor specimens were checked for estrogen receptor (ER), progestrone receptor (PR), and HER2 status by immunohistochemical stain. Prognostic factors such as performance status, status of metastases, history of prior anthracycline response, and biomarkers such as ER and HER2 were analyzed.


RESULTS
Ninety patients were eligible for HER2 assessment. Only eighty-five patients were eligible for response assessment. The overall response rate to chemotherapy with the taxanes/cisplatin regimen was 52%. In patients who were HER2-positive, the response rate was 62% and in HER2-negative patients, it was 46%, p= 0.17. Univariate analysis showed no prognostic factors were significant in predicting a response to chemotherapy. In addition, it appeared that there was no difference in time to progression and overall survival based on HER2 status.


CONCLUSIONS
Our results indicated that HER2 status is independent of a response to a taxanes/cisplatin combination and is also not a prognostic factor for survival.
Hsu
Hung-Chih
HC
Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan.
Chang
Hsien-Kun
HK
Lin
Yung-Chang
YC
Hseu
Sheu
S
Chen
Jen-Shi
JS
Yang
Tsai-Shen
TS
Wang
Hung-Ming
HM
Shen
Wen-Chi
WC
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D018734:Genes, erbB-2 / Q000502:physiology*; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012189:Retrospective Studies; D043823:Taxoids / Q000008:administration & dosage*
D015415:Biomarkers; D043823:Taxoids; D002945:Cisplatin