title: [Synthesis and physico-chemical characterisation of some new derivatives of rutoside and clofibric acid].
abstract: Fibrates are drugs with efficacy in reducing blood cholesterol levels and especially, triglyceride plasma levels. Unfortunately, fibrates have a poor water-solubility and showed some adverse reactions at long treatment. The objective of this study was to obtain some new clofibric acid derivatives with rutin; some of these compounds contain a guanidine moiety, known as effective at cardiovascular level. All the compounds are soluble in water.
authors.affiliation: Universitatea de Medicină şi Farmacie "Gr.T. Popa" Iaşi, Facultatea de Farmacie, Disciplina de Chimie farmaceutică.
authors.forename: D
authors.initials: D
authors.lastname: Lupaşcu
authors.forename: Lenuţa
authors.initials: L
authors.lastname: Profire
authors.forename: Gh
authors.initials: G
authors.lastname: Dănilă
mesh_terms: D002318:Cardiovascular Diseases / Q000188:drug therapy; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D012431:Rutin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D014867:Water
chemical_list: D000960:Hypolipidemic Agents; D014867:Water; D002995:Clofibric Acid; D012431:Rutin