Clinical predictive factors for preterm birth in women with threatened preterm labour or preterm premature ruptured membranes?
BACKGROUND
Independent predictive factors of preterm delivery were evaluated using clinical data at hospitalisation by multivariate analysis.


OBJECTIVE
The aim of this study was to clarify independent predictive factors related to preterm delivery by multivariate analysis of clinical data at hospitalisation of patients with threatened preterm delivery or premature rupture of membranes (PROM), and to realise the early and highly reliable prediction of preterm delivery in pregnant women at risk.


METHODS
The subjects were 200 patients, which diagnosed with threatened preterm delivery or PROM and admitted at gestational ages of 22-35 weeks. Univariate and multivariate analyses were performed; 20 factors were evaluated concerning clinical data, and we extracted prognostic factors using logistic regression analysis.


RESULTS
The mean age of the patients was 30.5 years, and the mean gestational age at admission was 30.0 weeks. Preterm delivery was observed in 55 (27.5%), and term delivery in 145 (72.5%). On multivariate analysis, haemorrhage, prepregnancy body mass index, fetal fibronectin and cervical length were extracted as independent predictive factors related to preterm delivery.


CONCLUSIONS
If the reliable and reproducible prediction of preterm delivery becomes possible using the four factors extracted in this study, further evaluation of these factors may lead to clarification of the mechanism of preterm delivery.
Yoneyama
Keiichiro
K
Health Service Center, Showa University, Tokyo, Japan. yoneyama@med.showa-u.ac.jp
Kimura
Aiko
A
Kogo
Mari
M
Kiuchi
Yuji
Y
Morimoto
Taro
T
Okai
Takashi
T
D000328:Adult; D015992:Body Mass Index; D002584:Cervix Uteri / Q000033:anatomy & histology; D005260:Female; D005322:Premature Rupture of Fetal Membranes; D005353:Fibronectins / Q000032:analysis; D006801:Humans; D016017:Odds Ratio; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D047928:Premature Birth / Q000175:diagnosis* / Q000209:etiology; D012307:Risk Factors; D014592:Uterine Hemorrhage / Q000150:complications
C403421:FFN protein, human; D005353:Fibronectins