Oxidative stress but not endothelial dysfunction exists in non-obese, young group of patients with polycystic ovary syndrome.
OBJECTIVE
To determine if oxidative stress and endothelial dysfunction exist at the same time in a young, non-obese group of patients with polycystic ovary syndrome (PCOS).


METHODS
Cross-sectional study.


METHODS
Celal Bayar University, School of Medicine, Manisa, Turkey.


METHODS
Thirty-one young, non-obese patients with PCOS and 23 age- and body mass index-matched controls.


METHODS
Following clinical and biochemical diagnosis, malonyldialdehyde (MDA), superoxide dismutase (SOD), von Willebrand Factor (vWF), and nitric oxide (NO) levels of patients and controls were measured and compared.


METHODS
To find out oxidative stress and endothelial dysfunction parameters.


RESULTS
MDA (0.12+/-0.03 vs 0.10+/-0.03, p=0.01) and SOD (8.0+/-0.7 vs 7.28+/-0.8, p=0.001) levels were significantly higher in PCOS group while there was no difference in vWF (527.2+/-280.1 vs 568.1+/-276.8, p>0.05) and NO levels (169.9+/-47.4 vs 168.9+/-80, p>0.05). When the results of the PCOS patients were divided into two subgroups in terms of insulin resistance (IR- and IR + ), the IR- subgroup had significantly higher MDA levels compared to the control (0.125+/-0.03 vs 0.101+/-0.03, p=0.03). Though IR+ group also had higher MDA than the control group, it did not reach to a significant level (0.117+/-0.05 vs 0.101+/-0.03, p>0.05). Both IR- and IR+ groups had significantly higher SOD levels compared with control group (7.99+/-0.7 vs 7.28+/-0.8, p=0.009 and 8.22+/-0.8 vs 7.28+/-0.8, p=0.03, respectively). vWF and NO levels were not different among these three groups (p>0.05).


CONCLUSIONS
Oxidative stress is prominent while endothelial dysfunction does not exist in young, non-obese patients with PCOS.
Kuşçu
Naci Kemal
NK
Department of Obstetrics & Gynecology, School of Medicine, Celal Bayar University, Manisa, Turkey. kemal.kuscu@bayar.edu.tr
Var
Ahmet
A
D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology*; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012307:Risk Factors; D013482:Superoxide Dismutase / Q000097:blood; D013851:Thinness; D014421:Turkey; D055815:Young Adult; D014841:von Willebrand Factor / Q000378:metabolism
D014841:von Willebrand Factor; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase