title: Ganoderic acid DM: anti-androgenic osteoclastogenesis inhibitor.
abstract: Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis.
authors.affiliation: Department of Forest and Forest Products Science, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Shiono
authors.forename: Kuniyoshi
authors.initials: K
authors.lastname: Shimizu
authors.forename: Akiko
authors.initials: A
authors.lastname: Kukita
authors.forename: Toshio
authors.initials: T
authors.lastname: Kukita
authors.forename: Ryuichiro
authors.initials: R
authors.lastname: Kondo
mesh_terms: D000726:Androgen Antagonists / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006131:Growth Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008297:Male; D051379:Mice; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D020940:Reishi; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D014315:Triterpenes; C528901:ganoderic acid D