title: Rotation of organizer tissue contributes to left-right asymmetry.
abstract: Current hypotheses regarding vertebrate left-right asymmetry patterns are based on the presumption that genetic regulatory networks specify sidedness via extracellular morphogens and/or ciliary activity. We show empirical time-lapse evidence for an asymmetric rotation of epiblastic nodal tissue in avian embryos. This rotation spans the interval when initial symmetric expression of Shh and Fgf8 becomes asymmetrical with respect to the midline.
authors.affiliation: Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Cui
authors.forename: Charles D
authors.initials: CD
authors.lastname: Little
authors.forename: Brenda J
authors.initials: BJ
authors.lastname: Rongish
mesh_terms: D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002642:Chick Embryo; D047108:Embryonic Development / Q000502:physiology*; D051524:Fibroblast Growth Factor 8 / Q000235:genetics / Q000378:metabolism; D007839:Functional Laterality / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D053823:Hedgehog Proteins / Q000235:genetics / Q000378:metabolism; D018715:Microscopy, Video / Q000379:methods*; D020897:Organizers, Embryonic / Q000166:cytology / Q000196:embryology*; D012399:Rotation; D013997:Time Factors
chemical_list: D053823:Hedgehog Proteins; D051524:Fibroblast Growth Factor 8