Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonials.
The ABCC subfamily of proteins is composed of nine members in Leishmania. We report that all of these proteins have an intracellular localization and that the overexpression of at least four members, ABCC3, ABCC4, ABCC5, and ABCC7, can confer resistance to antimonials, the first-line drug against Leishmania.
Leprohon
Philippe
P
Centre de Recherche en Infectiologie, Université Laval, Québec, Canada G1V 4G2.
Légaré
Danielle
D
Ouellette
Marc
M
D018528:ATP-Binding Cassette Transporters / Q000032:analysis / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D000965:Antimony / Q000494:pharmacology*; D004351:Drug Resistance; D007891:Leishmania / Q000737:chemistry / Q000187:drug effects*; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000032:analysis / Q000502:physiology*; D013972:Thyrotropin / Q000032:analysis
D018528:ATP-Binding Cassette Transporters; D015800:Protozoan Proteins; D013972:Thyrotropin; D000965:Antimony