Laboratory interferences with the newer cyanide antidote: hydroxocobalamin.
Cyanide poisoning occurs in many smoke inhalation victims. The newest FDA-approved treatment for acute cyanide intoxication is hydroxocobalamin (Cyanokit). However, hydroxocobalamin exhibits chemical properties that can disrupt several clinical laboratory tests. Knowledge of these effects on laboratory tests can be useful in assisting laboratory technicians and clinicians in managing these patients. This article briefly discusses acute cyanide poisoning and treatment, and summarizes laboratory interferences that have been reported with the use of hydroxocobalamin.
Beckerman
Nathan
N
Department of Emergency Medicine, Madigan Army Medical Center, Tacoma, Washington 98431, USA.
Leikin
Scott M
SM
Aitchinson
Robert
R
Yen
May
M
Wills
Brandon K
BK
D000931:Antidotes / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D019411:Clinical Laboratory Techniques; D003486:Cyanides / Q000037:antagonists & inhibitors / Q000506:poisoning*; D004347:Drug Interactions; D006801:Humans; D006879:Hydroxocobalamin / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D066298:In Vitro Techniques; D011933:Reagent Kits, Diagnostic; D014803:Vitamin B Complex / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*
D000931:Antidotes; D003486:Cyanides; D011933:Reagent Kits, Diagnostic; D014803:Vitamin B Complex; D006879:Hydroxocobalamin