title: Predictors of postoperative quality of life after esophagectomy for cancer.
abstract: OBJECTIVE
  To identify factors predictive of health-related quality of life (HRQL) 6 months after surgery for esophageal cancer.
  
  
  METHODS
  A Swedish nationwide population-based study of patients undergoing esophagectomy for cancer was undertaken between 2001 and 2005. Clinical details (sex, age, body mass index [BMI], comorbidity) and tumor details (histology, stage, and location) were prospectively recorded and validated. HRQL questionnaires (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires C30 and OES18) were used to assess HRQL 6 months postoperatively. HRQL outcome was categorized as good or poor by collapsing the four response categories. Logistic regression models adjusting for potential confounding factors were used to assess the association between preoperative patient and tumor characteristics and HRQL outcome 6 months after surgery.
  
  
  RESULTS
  A total of 355 patients (77% of eligible) responded to the HRQL questionnaires. Age, sex, and BMI showed no associations with HRQL 6 months after surgery, but patients with comorbidity, a more advanced tumor stage (III to IV), or a tumor located in the middle or upper esophagus had an increased risk of poor HRQL. Patients with adenocarcinoma had a lower risk of poor HRQL than patients with squamous cell carcinoma.
  
  
  CONCLUSIONS
  Knowledge of risk factors for poor postoperative HRQL may be relevant for clinical decision making. More research to see whether these factors are further predictive of poor HRQL in long-term survivors is needed.
authors.affiliation: Unit of Esophageal and Gastric Research P9:03, Department of Molecular Medicine and Surgery, Karolinska Institutet, SE-171 76 Stockholm, Sweden. therese.djarv@karolinska.se
authors.forename: Therese
authors.initials: T
authors.lastname: Djärv
authors.forename: Jane M
authors.initials: JM
authors.lastname: Blazeby
authors.forename: Pernilla
authors.initials: P
authors.lastname: Lagergren
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000523:psychology / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000523:psychology / Q000601:surgery; D015331:Cohort Studies; D004938:Esophageal Neoplasms / Q000473:pathology / Q000523:psychology* / Q000601:surgery*; D016629:Esophagectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome