title: Prognostic significance of stress myocardial ECG-gated perfusion imaging in asymptomatic patients with diabetic chronic kidney disease on initiation of haemodialysis.
abstract: OBJECTIVE
  Diabetic patients with chronic kidney disease (CKD) frequently develop cardiac events within several years of the initiation of haemodialysis. The present study assesses the prognostic significance of stress myocardial ECG-gated perfusion imaging (MPI) in patients with diabetic CKD requiring haemodialysis.
  
  
  METHODS
  Fifty-five asymptomatic patients with diabetic stage V CKD and no history of heart disease scheduled to start haemodialysis were enrolled in this study (56 +/- 11 years old; 49 with type 2 diabetes mellitus). All patients underwent (201)Tl stress ECG-gated MPI 1 month before or after the initiation of haemodialysis to assess myocardial involvement. We evaluated SPECT images using 17-segment defect scores graded on a 5-point scale, summed stress score (SSS) and summed difference scores (SDS). The patients were followed up for at least 2 years (42 +/- 15 months) to determine coronary intervention (CI) and heart failure (HF) as soft events and acute myocardial infarction (AMI) and all causes of deaths as hard events.
  
  
  RESULTS
  The frequencies of myocardial ischaemia, resting perfusion defects, low ejection fraction and left ventricular (LV) dilatation were 24, 20, 29 and 49%, respectively. Ten events (18%) developed during the follow-up period including four CI, one HF, one AMI and four sudden deaths. Multivariate Cox analysis selected SDS (p = 0.0011) and haemoglobin A(1c) (HbA(1c)) (p = 0.0076) as independent prognostic indicators for all events.
  
  
  CONCLUSIONS
  Myocardial ischaemia, in addition to glycaemic control, is a strong prognostic marker for asymptomatic patients with diabetic CKD who are scheduled to start haemodialysis. Stress MPI is highly recommended for the management and therapeutic stratification of such patients.
authors.affiliation: Department of Radiology, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. mmomose@rad.twmu.ac.jp
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Momose
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Babazono
authors.forename: Chisato
authors.initials: C
authors.lastname: Kondo
authors.forename: Hideki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Takatomo
authors.initials: T
authors.lastname: Nakajima
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Kusakabe
mesh_terms: D000704:Analysis of Variance; D055424:Cardiac-Gated Imaging Techniques; D002908:Chronic Disease / Q000628:therapy; D048909:Diabetes Complications / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007511:Ischemia / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D007674:Kidney Diseases / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D055414:Myocardial Perfusion Imaging; D011379:Prognosis; D006435:Renal Dialysis; D013312:Stress, Physiological; D015996:Survival Rate