title: "Nearly a stairway to heaven"--severe dichromate intoxication in a young man.
abstract: A 22-year-old man presented with dichromate intoxication in a suicidal attempt. He exhibited signs of liver and renal toxicity and very high serum chromium levels. Since it has been reported in the literature that hemodialysis and hemoperfusion are not sufficient to remove chromium, we tried plasmapheresis considering the fact that chromium salts bind to protein. Five plasmapheresis treatment sessions significantly lowered his serum and urinary chromium concentrations. The patient survived without organ damage despite ingestion of a lethal dichromate dose and high serum chromium concentration. Thus, plasmapheresis should be considered as a potential therapeutic option to reduce chromium concentrations.
authors.affiliation: Department of Internal Medicine III, Friedrich Schiller University Jena, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Illner
authors.forename: J
authors.initials: J
authors.lastname: Gerth
authors.forename: R
authors.initials: R
authors.lastname: Pfeiffer
authors.forename: T
authors.initials: T
authors.lastname: Bruns
authors.forename: G
authors.initials: G
authors.lastname: Wolf
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy*; D000328:Adult; D002857:Chromium / Q000506:poisoning*; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D011041:Poisoning / Q000628:therapy*; D013406:Suicide, Attempted
chemical_list: D002857:Chromium