Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension.
BACKGROUND
We performed a meta-analysis to assess the association of ACE2 G8790A polymorphism with essential hypertension.


METHODS
The references were retrieved through MEDLINE, Wanfang and VIP Information.The analyses were performed by the software STATA 9.0.


RESULTS
No significant publication bias was observed.The combined data showed no association of the frequencies of the A allele with essential hypertension odds ratio (OR)=1.09 95% confidence interval (CI)=0.98-1.20;p=0.11 in female patients. No associations were shown between the frequencies of the A allele with the genetic susceptibility to essential hypertension in male patients (OR=1.11 95% CI=0.95-1.29; p=0.19).


CONCLUSIONS
The meta-analysis suggests that ACE2 G8790A polymorphism may not be a genetic risk factor for essential hypertension in a Chinese Han population.
Zhou
Jian-Bo
JB
Division of Endocrinology and Metabolism, Beijing Tongren Hospital affiliated to Capital Medical University, Beijing, China.
Yang
Jin-Kui
JK
D000085962:Angiotensin-Converting Enzyme 2; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D016017:Odds Ratio; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017594:Publication Bias
D007703:Peptidyl-Dipeptidase A; C000705307:ACE2 protein, human; D000085962:Angiotensin-Converting Enzyme 2