title: Multiwalled carbon nanotubes specifically inhibit osteoclast differentiation and function.
abstract: Since attention has been paid to the use of multiwalled carbon nanotubes (MWCNTs) as biomaterials in contact with bone, it is critical to understand the reaction of bone cells to MWCNTs. We show that MWCNTs inhibit osteoclastic bone resorption in vivo and that MWCNTs inhibit osteoclastic differentiation and suppressed a transcription factor essential for osteoclastogenesis in vitro. These results suggest that MWCNTs have beneficial effects on bones when they are used as biomaterials.
authors.affiliation: Department of Orthopedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi Matsumoto, Nagano, Japan.
authors.forename: Nobuyo
authors.initials: N
authors.lastname: Narita
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Maeda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ishihara
authors.forename: Toshihide
authors.initials: T
authors.lastname: Mizoguchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Usui
authors.forename: Kaoru
authors.initials: K
authors.lastname: Aoki
authors.forename: Masayuki
authors.initials: M
authors.lastname: Simizu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Ozawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Udagawa
authors.forename: Morinobu
authors.initials: M
authors.lastname: Endo
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Takahashi
authors.forename: Naoto
authors.initials: N
authors.lastname: Saito
mesh_terms: D001672:Biocompatible Materials; D001862:Bone Resorption; D002454:Cell Differentiation; D037742:Nanotubes, Carbon; D010010:Osteoclasts / Q000166:cytology*
chemical_list: D001672:Biocompatible Materials; D037742:Nanotubes, Carbon