title: A comparison of the pathogenicity of avian and swine H5N1 influenza viruses in Indonesia.
abstract: Highly pathogenic avian influenza H5N1 viruses are circulating in many countries. We recently discovered that these viruses have been transmitted to pigs on multiple occasions in Indonesia. To investigate whether avian H5N1 influenza viruses adapted to mammals through their introduction into pigs, we examined the growth of avian and swine isolates in cell culture and compared their pathogenicity in mice. We found that swine isolates were less virulent to mice than avian isolates, suggesting that the viruses became attenuated during their replication in pigs. Continuous surveillance of H5N1 viruses among pigs is clearly warranted.
authors.affiliation: Department of Microbiology and Immunology, University of Tokyo, Shirokanedai, Minato-ku, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Takano
authors.forename: Chairul A
authors.initials: CA
authors.lastname: Nidom
authors.forename: Maki
authors.initials: M
authors.lastname: Kiso
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Muramoto
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamada
authors.forename: Kyoko
authors.initials: K
authors.lastname: Shinya
authors.forename: Yuko
authors.initials: Y
authors.lastname: Sakai-Tagawa
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kawaoka
mesh_terms: D000818:Animals; D001717:Birds; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D007214:Indonesia; D053124:Influenza A Virus, H5N1 Subtype / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity*; D005585:Influenza in Birds / Q000821:virology*; D007928:Lethal Dose 50; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014774:Virulence
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; C109963:hemagglutinin, avian influenza A virus