title: High-risk population for gastric cancer development based on serum pepsinogen status and lifestyle factors.
abstract: BACKGROUND
  Gastric atrophy is a major risk factor for non-cardiac gastric cancer. Serum pepsinogen status could identify people at high-risk for gastric cancer development during our previous cohort study. However, lifestyle-related factors may additionally affect this risk.
  
  
  METHODS
  A total of 6983 Japanese were followed up by annual endoscopy in the previous study, and 43 cases of gastric cancer including two cardiac cancers developed. In most subjects, the body length and weight were measured and a questionnaire was applied to gather information regarding life habits. The risk of non-cardiac gastric cancer development during surveillance was re-analyzed based on serum pepsinogen, sex, age, body mass index (BMI), alcohol, and smoking habit.
  
  
  RESULTS
  A total of 6158 subjects with 37 non-cardiac gastric cancer development (male/female = 4259/1899, mean age = 49.0, mean follow-up period = 4.79 years) were entered into analysis. In a multivariate analysis, old age (by 10 years; (odds ratio) OR, 2.8; p < .001), alcohol (weekly; OR, 2.4; p = .03), smoking (current; OR, 5.6; p = .006 and past; OR, 3.9; p = .04), and pepsinogen status ("atrophic"; OR, 6.2; p < .001) were independent risk factors, whereas BMI was not. The annual incidence of gastric cancer was 1.2% in the older subjects aged > or = 60 years with "atrophic" pepsinogen status. Moreover, it was as high as 2.9% when they had both alcohol and current smoking habits.
  
  
  CONCLUSIONS
  Old age, alcohol, and smoking habits additionally promoted the risk for gastric cancer in subjects with gastric atrophy.
authors.affiliation: Department of Gastroenterology, University of Tokyo, Tokyo, Japan. yamaji-tky@umin.ac.jp
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamaji
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Watabe
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Yoshida
authors.forename: Takao
authors.initials: T
authors.lastname: Kawabe
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Wada
authors.forename: Toru
authors.initials: T
authors.lastname: Mitsushima
authors.forename: Masao
authors.initials: M
authors.lastname: Omata
mesh_terms: D000328:Adult; D000428:Alcohol Drinking; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008019:Life Style; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors; D012907:Smoking; D013274:Stomach Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000473:pathology
chemical_list: D020116:Pepsinogen A