Review: cellular metabolism: contribution to postoperative adhesion development.
Postoperative adhesions are a significant source of morbidity, including contributions to pelvic pain, bowel obstruction, and infertility. While the mechanisms of postoperative adhesion development are complex and incompletely understood, hypoxia appears to trigger a cascade of intracellular responses involving hypoxia-inducible factors, lactate, reactive oxygen species, reactive nitrogen species, and insulin-like growth factors that results in manifestation of the adhesion phenotype. Thus, substantial evidence exists to implicate the direct role of cellular metabolism in wound repair and adhesion development.
Shavell
Valerie I
VI
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Saed
Ghassan M
GM
Diamond
Michael P
MP
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism / Q000473:pathology; D006801:Humans; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*; D000267:Tissue Adhesions / Q000209:etiology / Q000378:metabolism* / Q000473:pathology*