Herpes zoster keratouveitis and inflammatory ocular hypertension 8 years after varicella vaccination.
More than 8 years after varicella vaccination, a healthy 16 year-old boy presented with keratouveitis, severe inflammatory glaucoma in his left eye, and Hutchinson's sign. He was treated with systemic acyclovir, topical steroids, cycloplegics, and glaucoma medications for a full recovery two months after presentation. It is unclear whether the source of herpes zoster which reactivated in this patient represents wild type virus or his previous vaccine strain. Herpes zoster ophthalmicus is very rare in the pediatric population after varicella vaccination but can cause severe inflammatory glaucoma that requires aggressive therapy.
Lin
Phoebe
P
Department of Ophthalmology, University of California San Francisco, San Francisco, California, USA.
Yoon
Michael K
MK
Chiu
Cynthia S
CS
D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000959:Antihypertensive Agents / Q000627:therapeutic use; D019433:Chickenpox Vaccine / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D006563:Herpes Zoster Ophthalmicus / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000502:physiology; D006801:Humans; D007429:Intraocular Pressure; D016849:Keratitis, Herpetic / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D008297:Male; D009184:Mydriatics / Q000627:therapeutic use; D009798:Ocular Hypertension / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014606:Uveitis, Anterior / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014611:Vaccination; D014775:Virus Activation / Q000502:physiology
D000959:Antihypertensive Agents; D019433:Chickenpox Vaccine; D005938:Glucocorticoids; D009184:Mydriatics; D000212:Acyclovir