Influence of type and neutralisation capacity of antacids on dissolution rate of ciprofloxacin and moxifloxacin from tablets.
Dissolution rate of two fluoroquinolone antibiotics (ciprofloxacin and moxifloxacin) was analysed in presence/absence of three antacid formulations. Disintegration time and neutralisation capacity of antacid tablets were also checked. Variation in disintegration time indicated the importance of this parameter, and allowed evaluation of the influence of postponed antacid-fluoroquinolone contact. The results obtained in this study showed decreased dissolution rate of fluoroquinolone antibiotics from tablets in simultaneous presence of antacids, regardless of their type and neutralisation capacity.
Uzunović
Alija
A
Institute for Quality Control of Medicines, Titova 9, 71 000 Sarajevo, Bosnia and Herzegovina.
Vranić
Edina
E
D000863:Antacids / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000493:pharmacokinetics*; D001372:Aza Compounds / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002939:Ciprofloxacin / Q000737:chemistry*; D024841:Fluoroquinolones / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D000077266:Moxifloxacin; D011804:Quinolines / Q000737:chemistry*; D013607:Tablets
D000863:Antacids; D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D013607:Tablets; D002939:Ciprofloxacin; D000077266:Moxifloxacin