Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and alpha-tocopherol presents in the extract of leaves of Cissus sicyoides L. (Vitaceae).
The aim of the present study is to demonstrate the anxiolytic and anticonvulsant effects of a hydroalcoholic extract obtained from the aerial parts of Cissus sicyoides L. (CS) (Vitaceae) on male and female mice using several behavioral assays. Groups of males and females treated via intraperitoneal (IP) with doses of 300, 600, and 1000 mg/kg of the extract showed significant action in the elevated plus-maze (EPM), time spent in the open arms, and number of entries in the open arms. The board-hole test also showed a significant increase in the time spent in head-dipping and in marble-burying test of the number of marbles buried. The same treatment increased the duration of sleeping time induced by sodium pentobarbital and also showed a significant increase in protection against pentylenotetrazole-induced convulsions. These results indicate an anxiolytic and anticonvulsant-like action from C. sicyoides L. extract on mice, probably due to the action of flavonoid(s), Linalool, and alpha-tocopherol present in the C. sicyoides leaves.
de Almeida
Edvaldo Rodrigues
ER
Evaluation Laboratory of Psychobioactive and Toxicology, Department of Antibiotics, Federal University of Pernambuco, 50670-901 Recife, PE, Brazil. edvaldo.ra@gmail.com
Rafael
Krissia Rayane de Oliveira
KR
Couto
Geraldo Bosco Lindoso
GB
Ishigami
Ana Beatriz Matos
AB
D000080462:Acyclic Monoterpenes; D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D032422:Cissus / Q000737:chemistry*; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D012640:Seizures; D012890:Sleep / Q000187:drug effects; D024502:alpha-Tocopherol / Q000008:administration & dosage / Q000494:pharmacology*
D000080462:Acyclic Monoterpenes; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D005419:Flavonoids; D039821:Monoterpenes; D010936:Plant Extracts; C018584:linalool; D024502:alpha-Tocopherol