title: Progress of multiple cutaneous and subcutaneous melanoma metastases of the face during imiquimod treatment.
abstract: A 68-year-old man developed a local recurrence with multiple cutaneous and subcutaneous nodules three months after excision of a primary malignant melanoma of the temple. Despite extensive surgery and adjuvant irradiation, another local recurrence occurred. Following further local progression during dacarbazine chemotherapy, topical treatment with imiquimod was begun and the chemotherapy was changed to fotemustine. During this treatment further local progression occurred and two months later regional lymph node and distant metastasis were detected. The patient died from his tumor disease eighteen months after the first diagnosis of malignant melanoma.
authors.affiliation: Klinik für Hautkrankheiten und Allergologie, HELIOS Vogtland-Klinikum Plauen GmbH, Plauen. lutz.kowalzick@helios-kliniken.de
authors.forename: Lutz
authors.initials: L
authors.lastname: Kowalzick
authors.forename: Lena
authors.initials: L
authors.lastname: Eickenscheidt
mesh_terms: D000368:Aged; D000634:Aminoquinolines / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005153:Facial Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D000077271:Imiquimod; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000556:secondary*; D012878:Skin Neoplasms / Q000188:drug therapy*; D017211:Treatment Failure
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod