Benzaldehyde-functionalized polymer vesicles.
Polymer vesicles with diameters of ca. 100-600 nm and bearing benzaldehyde functionalities within the vesicular walls were constructed through self-assembly of an amphiphilic block copolymer PEO(45)-b-PVBA(26) in water. The reactivity of the benzaldehyde functionalities was verified by cross-linking the polymersomes and also by a one-pot cross-linking and functionalization approach to further render the vesicles fluorescent, each via reductive amination. In vitro studies found these labeled nanostructures to undergo cell association.
Sun
Guorong
G
Department of Chemistry, Washington University in Saint Louis, Saint Louis, Missouri 63130, USA.
Fang
Huafeng
H
Cheng
Chong
C
Lu
Peng
P
Zhang
Ke
K
Walker
Amy V
AV
Taylor
John-Stephen A
JS
Wooley
Karen L
KL
D000818:Animals; D001547:Benzaldehydes / Q000737:chemistry*; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D003432:Cross-Linking Reagents / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D001547:Benzaldehydes; D003432:Cross-Linking Reagents; D011108:Polymers; D014867:Water; C032175:benzaldehyde