Cell cycle regulatory control for uterine stromal cell decidualization in implantation.
Uterine stromal cell decidualization is integral to successful embryo implantation, which is a gateway to pregnancy establishment. This process is characterized by stromal cell proliferation and differentiation into decidual cells with polyploidy. The molecular mechanisms that are involved in these events remain poorly understood. The current concept is that locally induced factors with the onset of implantation influence uterine stromal cell proliferation and/or differentiation through modulation of core cell cycle regulators. This review will aim to address the currently available knowledge on interaction between growth factor/homeobox and cell cycle regulatory signaling in the progression of various aspects of decidualization.
Das
Sanjoy K
SK
Reproductive Sciences, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. sanjoy.das@cchmc.org
D000818:Animals; D002450:Cell Communication; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002454:Cell Differentiation; D049109:Cell Proliferation; D003656:Decidua / Q000166:cytology / Q000378:metabolism*; D010064:Embryo Implantation; D004622:Embryo, Mammalian / Q000378:metabolism*; D005260:Female; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D011123:Polyploidy; D011247:Pregnancy; D015398:Signal Transduction; D017154:Stromal Cells / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism; D014599:Uterus / Q000166:cytology / Q000378:metabolism*
D018797:Cell Cycle Proteins; D036341:Intercellular Signaling Peptides and Proteins; D014157:Transcription Factors