Three-dimensional time-of-flight magnetic resonance angiography of intracranial vessels in a canine model of ischemic stroke with permanent occlusion of the middle cerebral artery.
The purpose of this study was to evaluate the potential efficacy of 3-dimensional time-of-flight magnetic resonance angiography (TOF-MRA) to validate a canine ischemic stroke model. Ischemic stroke was induced through permanent middle cerebral artery occlusion (MCAO) in 5 healthy Beagle dogs. T2-turbo spin echo images and TOF-MRA were obtained with a 1.5-T magnetic resonance system before and 3 and 10 d after MCAO. In 3 dogs, angiograms of the brain obtained at 3 d after MCAO showed complete occlusion of the MCA; in addition, T2 hyperintensities were present unilaterally in the striatocapsular and cerebral cortex lesions. Partial occlusion of the proximal part of the MCA was identified in the 2 remaining dogs, with T2 hyperintensities present only in the striatocapsular lesions. The occluded sites were confirmed at necropsy. The results of this study demonstrate the potential of TOF-MRA to provide a detailed description of intracranial arteries and aid in the evaluation of flow impairment in a canine MCAO model.
Kang
Byeong-Teck
BT
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, Republic of Korea.
Jang
Dong-Pyo
DP
Gu
Su-Hyun
SH
Kim
Young-Bo
YB
Lim
Chae-Young
CY
Lee
Jong-Hwan
JH
Woo
Eung-Je
EJ
Cho
Zang-Hee
ZH
Park
Hee-Myung
HM
D000818:Animals; D002545:Brain Ischemia / Q000150:complications / Q000473:pathology*; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D021621:Imaging, Three-Dimensional; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000473:pathology*; D018810:Magnetic Resonance Angiography / Q000295:instrumentation / Q000379:methods*; D008297:Male; D020768:Middle Cerebral Artery / Q000473:pathology*; D020521:Stroke / Q000209:etiology / Q000473:pathology*