title: [Efficacy of cellulose on functional constipation].
abstract: OBJECTIVE
  To assess the clinical efficacy and safety of cellulose on functional constipation.
  
  
  METHODS
  A prospective, self-controlled, multicenter clinical trial of cellulose was conducted for 2 weeks in 240 patients with functional constipation according to the Rome III( criteria. Symptoms and characters of feces before and after the treatment were observed and evaluated according to a score scheme.
  
  
  RESULTS
  In the 240 patients, the frequencies of defecation increased and the characters of feces was improved significantly after 2-week treatment. There were no adverse reactions observed throughout the clinical trial. The total efficacy was 82.1% at day 7 and 90.7% at day 14. The satisfactory rate of doctors was 83.8% and of patients was 83.8%.
  
  
  CONCLUSIONS
  Cellulose is effective and safe in the treatment of chronic functional constipation.
authors.affiliation: Research Institute of Surgery, Daping Hospital, Chongqing 400042, China. LBH57268@163.com
authors.forename: Bao-hua
authors.initials: BH
authors.lastname: Liu
authors.forename: Xin-qing
authors.initials: XQ
authors.lastname: Yang
authors.forename: Dong-lin
authors.initials: DL
authors.lastname: Ren
authors.forename: Yi-jiang
authors.initials: YJ
authors.lastname: Ding
authors.forename: Ke
authors.initials: K
authors.lastname: Zhao
authors.forename: Qun
authors.initials: Q
authors.lastname: Qian
authors.forename: Guan-gen
authors.initials: GG
authors.lastname: Yang
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002482:Cellulose / Q000627:therapeutic use*; D003248:Constipation / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002482:Cellulose