Interleukin-18 gene 105A/C genetic polymorphism is associated with the susceptibility of Kawasaki disease.
Interleukin-18 (IL-18)-656T/G, -607A/C, and -137C/G promoter polymorphisms had been reported associated with Kawasaki disease (KD). An IL-18 genetic A/C polymorphism at coding position 105 (rs549908) has been linked with asthma, rheumatoid, and systemic lupus erythematosus. We tested a hypothesis that the IL-18 105A/C genetic polymorphism confers KD susceptibility. Study participants were Taiwanese KD patients and a healthy control group. Our data indicated that the frequency of C allele was significantly higher in the patient group (13.9%) than in the control group (2.7%; P<0.0001, odds ratio [OR]=5.93; 95% confidence interval [CI]=2.57-13.73). Therefore, persons with the C allele may have higher risk of developing KD. In addition, compared with the haplotype frequencies between case and control groups, the KD patients with TACC haplotype appeared to be a significant "at-risk" haplotype compared with other haplotypes (OR: 4.62, 95% CI: 1.71-12.43; P=0.001). KD patient with the TAGA haplotype appeared to be a significant "protective" haplotype compared with other haplotypes (OR: 0.51, 95% CI:0.29-0.89; P=0.017). Our results suggest that 105A/C polymorphism and the haplotypes in IL-18 gene are associated with the risk of KD in Taiwanese population.
Chen
Shih-Yin
SY
Department of Medical Research, Department of Medical Genetics, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan.
Wan
Lei
L
Huang
Yu-Chuen
YC
Sheu
Jim Jinn-Chyuan
JJ
Lan
Yu-Ching
YC
Lai
Chih-Ho
CH
Lin
Cheng-Wen
CW
Chang
Jeng Sheng
JS
Tsai
Yuhsin
Y
Liu
Shih-Ping
SP
Lin
Ying-Ju
YJ
Tsai
Fuu-Jen
FJ
D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006239:Haplotypes; D006801:Humans; D007223:Infant; D020382:Interleukin-18 / Q000235:genetics*; D016015:Logistic Models; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan / Q000453:epidemiology
D020382:Interleukin-18