Immunohistochemical and molecular-pathological diagnosis of myocarditis in cases of suspected sudden infant death syndrome (SIDS)--a multicenter study.
Virus-induced myocarditis is a common disease even in infants and children, but diagnosis can be difficult according to the Dallas-criteria, which have been criticised as being too unreliable. The diagnosis has been substantially improved due to immunohistochemical techniques for characterization and quantification of myocardial inflammatory reactions as well as molecular-pathological methods for viral genome detection. The published studies report on post-mortem samples from SIDS victims and controls which were prospectively investigated. Pediatric cases of unnatural deaths served as controls. The results demonstrate a clearly higher prevalence of viral myocardial infections in cases of suspected SIDS. Preliminary criteria for cellular immunohistochemical diagnosis of viral myocardial affections derived from these findings were suggested.
Dettmeyer
Reinhard
R
Institute of Forensic Medicine, University of Giessen, Frankfurter Street 58, D-35392 Giessen, Germany. Reinhard.Dettmeyer@forens.med.uni-giessen.de
Baasner
Anne
A
Haag
Claudia
C
Bruch
Simone
S
Schlamann
Marc
M
D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D036022:Capsid Proteins / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D049429:Forensic Pathology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D017493:Leukocyte Common Antigens / Q000032:analysis; D007962:Leukocytes / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008297:Male; D009205:Myocarditis / Q000175:diagnosis* / Q000821:virology*; D009206:Myocardium / Q000473:pathology; D011446:Prospective Studies; D013398:Sudden Infant Death / Q000209:etiology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D036022:Capsid Proteins; D017493:Leukocyte Common Antigens; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C095547:capsid protein VP1, parvovirus B19