title: Caregiving for children with developmental disabilities is associated with a poor antibody response to influenza vaccination.
abstract: OBJECTIVE
  Older spousal caregivers of dementia patients have been found to show a relatively poor antibody response to medical vaccination. In the present case control study in a different caregiving environment, we sought to compare antibody responses to vaccination in parents of children with disabilities and parents of typically developing children.
  
  
  METHODS
  At baseline assessment, 32 parents of children with developmental disabilities and 29 parents of typically developing children completed standard measures of perceived stress and child problem behaviors. They also provided a blood sample and were then vaccinated with the thymus-dependent trivalent influenza vaccine. Further blood samples were taken at 1- and 6-month follow-ups.
  
  
  RESULTS
  Relative to parents of typically developing children (mean titer = 458, standard deviation (SD) = 155.7 at 1 month follow-up and mean titer = 265, SD = 483.0 at 6-month follow-up), caregivers (mean titer = 219, SD = 528.4 at 1-month follow-up and 86, SD = 55.0 at 6-month follow-up) mounted a poorer antibody response than controls to the B/Malaysia strain of the vaccine.
  
  
  CONCLUSIONS
  The negative impact of caregiving on antibody response to vaccination would not seem to be restricted to older spousal caregivers, but is also evident in younger parents caring for children with developmental disabilities. The behavioral characteristics of the care recipients may be a determinant of whether or not antibody response to vaccination is compromised.
authors.affiliation: Centre for Health Psychology, Staffordshire University, Stoke-on-Trent, UK. S.Gallagher@staffs.ac.uk
authors.forename: Stephen
authors.initials: S
authors.lastname: Gallagher
authors.forename: Anna C
authors.initials: AC
authors.lastname: Phillips
authors.forename: Mark T
authors.initials: MT
authors.lastname: Drayson
authors.forename: Douglas
authors.initials: D
authors.lastname: Carroll
mesh_terms: D000328:Adult; D000917:Antibody Formation / Q000276:immunology*; D017028:Caregivers / Q000523:psychology* / Q000706:statistics & numerical data*; D002648:Child; D002653:Child Behavior Disorders / Q000453:epidemiology; D002908:Chronic Disease; D002658:Developmental Disabilities; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D008297:Male; D013315:Stress, Psychological / Q000523:psychology; D011795:Surveys and Questionnaires; D014611:Vaccination / Q000706:statistics & numerical data
chemical_list: D007252:Influenza Vaccines