title: [Suggestions for prevention of adverse reactions after intravasal administration of iodinated contrast media].
abstract: Iodinated contrast media are widely used in computed tomography and angiography. Adverse reactions such as contrast-medium induced nephropathy (CIN), anaphylactoid reactions and iodine-induced thyrotoxicosis are associated with intravasal administration of contrast agents. Iodinated contrast agents are generally considered to be safe, but in rare cases they can cause severe life threatening situations. In this review we present an overview about the incidence, pathways, and risk factors of adverse reactions. Simple schemes including hydration protocols for prevention of CIN, medication for prophylaxis of iodine-induced thyrotoxicosis with thyreostatics and anaphylactoid reactions with histamine antagonists and corticosteroids are suggested.
authors.affiliation: Radiologisches Institut, Universität Erlangen-Nürnberg, Maximiliansplatz 1, D-91054 Erlangen, Germany. michael.kuefner@uk-erlangen.de
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kuefner
authors.forename: Marc
authors.initials: M
authors.lastname: Heinrich
authors.forename: Werner
authors.initials: W
authors.lastname: Bautz
authors.forename: Michael
authors.initials: M
authors.lastname: Uder
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000707:Anaphylaxis / Q000139:chemically induced* / Q000517:prevention & control; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D005919:Glomerular Filtration Rate; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D017613:Iodine Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000175:diagnosis; D015201:Meta-Analysis as Topic; D008687:Metformin / Q000009:adverse effects; D051379:Mice; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D013971:Thyrotoxicosis / Q000139:chemically induced* / Q000517:prevention & control; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D003287:Contrast Media; D007004:Hypoglycemic Agents; D017613:Iodine Compounds; D008687:Metformin; D003404:Creatinine