Synthesis of 3-aryl-8-oxo-5,6,7,8-tetrahydroindolizines via a palladium-catalyzed arylation and heteroarylation.
A selective palladium-catalyzed arylation and heteroarylation of 8-oxo-5,6,7,8-tetrahydroindolizines has been developed. Mechanistic studies assume an electrophilic substitution pathway for this transformation. This method provides an efficient one-step synthesis of 3-aryl-8-oxo-5,6,7,8-tetrahydroindolizines.
Gracia
Stéphanie
S
Laboratoire de Catalyse et Synthèse Organique, ICBMS,Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, CNRS, UMR 5246, Université de Lyon, 69622 Villeurbanne, France.
Cazorla
Clément
C
Métay
Estelle
E
Pellet-Rostaing
Stéphane
S
Lemaire
Marc
M
D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D007212:Indolizines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013329:Structure-Activity Relationship
C542741:2-phenyl-5,6,7,8-tetrahydroindolizine; D006571:Heterocyclic Compounds; D007212:Indolizines; D010165:Palladium