Dysfunctional response preparation and inhibition during a visual Go/No-go task in children with two subtypes of attention-deficit hyperactivity disorder.
While a response inhibition problem is well-established in children with attention-deficit/hyperactivity disorder of the combined subtype (AD/HDcom), the predominantly inattentive subtype (AD/HDin) has not been investigated previously. This study examined control versus subtype differences in visually evoked response inhibition using task performance and event-related potential (ERP) measures. Children with AD/HDcom (n=15) and AD/HDin (n=15) and age-matched controls (n=15) performed a cued visual Go/Nogo task requiring either activation or inhibition (30%) of a button-press response to the S2 (Go or Nogo stimulus) following the S1 (warning stimulus), presented 1380 ms earlier. Task performance and ERP indices of Warning, Go and Nogo stimulus processing, as well as preparation during the S1-S2 interval, were examined for group differences. Behavioural results indicated a response inhibition deficit in children with AD/HDcom and AD/HDin, with additional response activation problems in AD/HDcom. Topographic ERP differences between controls and both clinical groups suggested atypical (a) preparation for S2 as indexed by the late CNV, (b) early sensory/attentional processing of both S1 and S2, and (c) response inhibition as indexed by N2 and P3. In addition to replicating previous AD/HDcom findings, these results indicate that children with AD/HDin differ from controls in response preparation and inhibition during a cued visual Go/Nogo task.
Johnstone
Stuart J
SJ
School of Psychology, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia. sjohnsto@uow.edu.au
Clarke
Adam R
AR
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology*; D002648:Child; D002755:Choice Behavior; D003463:Cues; D003657:Decision Making; D004569:Electroencephalography; D005071:Evoked Potentials; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual; D011597:Psychomotor Performance; D011930:Reaction Time; D013647:Task Performance and Analysis