title: [Recurrent extramammary Paget's disease of the penis and scrotum: clinical analysis of 18 cases].
abstract: OBJECTIVE
  To investigate the causes, therapeutic methods and prognosis of recurrent extramammary Paget's disease of the penis and scrotum.
  
  
  METHODS
  We retrospectively studied the clinical presentations, therapeutic methods and prognosis of 18 cases of recurrent penile and scrotal Paget's disease, all diagnosed by biopsy and treated by surgical resection of the diseased sites. The incision reached the deep fascia. Frozen and olefin sections of the samples were pathologically examined to identify the involvement of the incisal edge. Seven cases had inguinal lymph node metastasis and underwent unilateral or bilateral inguinal lymph node resection.
  
  
  RESULTS
  All the patients were followed up for 6 months to 8 years (mean 34 months). Four died of distant metastasis and the other 14 experienced no recurrence.
  
  
  CONCLUSIONS
  For the cases without metastasis of recurrent penile and scrotal Paget's disease, extended lesion-resection is a preferred option and the prognosis is good. And those with local lymph node metastasis need to undergo local lymph node resection.
authors.affiliation: Department of Urology, Huashan Hospital Affiliated to Fudan University, Shanghai 200040, China.
authors.forename: Bing-Kun
authors.initials: BK
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Lu
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005834:Genital Neoplasms, Male / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000601:surgery*; D010412:Penile Neoplasms / Q000601:surgery; D011379:Prognosis; D012611:Scrotum