Cerebral MRI lesions and anti-tumor necrosis factor-alpha therapy.
We discuss two cases receiving different anti-tumornecrosis-factor alpha antagonists (anti-TNF-alpha); one for psoriatic arthritis (PA) and the other for ankylosing spondylitis (AS). Due to neurological symptoms cerebral magnetic resonance imaging (MRI) was performed and cerebral lesions were detected. Our interpretations of these cerebral lesions and the resulting diagnostic and therapeutic consequences are presented in regard of data published in the medical literature.
Winkelmann
Alexander
A
Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany. alexander.winkelmann@med.uni-rostock.de
Patejdl
Robert
R
Wagner
Sabine
S
Benecke
Reiner
R
Zettl
Uwe Klaus
UK
D000328:Adult; D000906:Antibodies / Q000009:adverse effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000276:immunology*
D000906:Antibodies; D014409:Tumor Necrosis Factor-alpha