[Botulinum toxin treatment : therapy success in cases of depression and ongoing pension applications].
BACKGROUND
A discrepancy is often observed between the presence of botulinum toxin antibodies (Btx-Ab) and successful therapy. We studied whether depression and an ongoing pension application explain this contradiction.


METHODS
Sixty-five patients treated with Btx were questioned for subjective therapy failure (TF). The extensor digitorum brevis test (EDB test) indicated the presence of Btx-Ab. The Beck Depression Inventory and an exploration investigated for a depressive disturbance as well as an ongoing application for pension. We correlated the EDB test and the TF with a depressive disturbance and the wish for a pension.


RESULTS
Forty-three patients had TF, from which 22 Btx-Ab were positive. A depressive disturbance was found in 25 patients, and an ongoing application for pension in 21. The EDB test and TF did not however correlate TF with a depressive disturbance (P=0.003) and a pension desire (P=0.021). The TF mostly appeared at the beginning of treatment.


CONCLUSIONS
A depressive disturbance and an ongoing application for a pension influence the therapeutic success more strongly initially than the development of Btx-Ab.


CONCLUSIONS
Besides Btx-Ab a depressive disturbance and an ongoing application for pension influences the therapeutic success.
Bachhuber
A
A
Fachabteilung Neurologie, Paracelsus-Klinik , Werdauer Strasse 68, 08060, Zwickau, Deutschland. BachhuberA@web.de
Reichel
G
G
Doberenz
M
M
Stenner
A
A
Hermann
W
W
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001905:Botulinum Toxins / Q000627:therapeutic use*; D003863:Depression / Q000175:diagnosis* / Q000188:drug therapy*; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010415:Pensions; D016896:Treatment Outcome; D055815:Young Adult
D001905:Botulinum Toxins