title: Lung transplantation: does oxidative stress contribute to the development of bronchiolitis obliterans syndrome?
abstract: Lung transplantation is the ultimate treatment of end-stage lung disease. After transplantation, the 1-year survival rate is 80%. However, 5-year survival rates drop to 50% due to bronchiolitis obliterans syndrome (BOS). Ischemia/reperfusion injury, infections, and acute rejection are major risk factors contributing to the development of BOS. These risk factors are also associated with increased oxidative stress. Oxidative stress is a condition whereby prooxidants overwhelm the antioxidant defense system and may contribute to the pathogenesis of BOS by inducing more tissue injury and inflammation. This article reviews the current state of knowledge on oxidative stress in lung transplantation and BOS.
authors.affiliation: University of Toronto, Lung Transplant Program, University Health Network, Toronto, ON, Canada.
authors.forename: Janet
authors.initials: J
authors.lastname: Madill
authors.forename: Ellie
authors.initials: E
authors.lastname: Aghdassi
authors.forename: Bianca
authors.initials: B
authors.lastname: Arendt
authors.forename: Brenda
authors.initials: B
authors.lastname: Hartman-Craven
authors.forename: Carlos
authors.initials: C
authors.lastname: Gutierrez
authors.forename: Chung-Wai
authors.initials: CW
authors.lastname: Chow
authors.forename: Johane
authors.initials: J
authors.lastname: Allard
mesh_terms: D001989:Bronchiolitis Obliterans / Q000209:etiology* / Q000378:metabolism* / Q000401:mortality; D006801:Humans; D016040:Lung Transplantation / Q000401:mortality; D018384:Oxidative Stress / Q000502:physiology*; D011183:Postoperative Complications / Q000209:etiology / Q000378:metabolism / Q000401:mortality; D012307:Risk Factors