title: Charge-conversional polyionic complex micelles-efficient nanocarriers for protein delivery into cytoplasm.
abstract: Special delivery! Polyionic complex (PIC) micelles that contain the charge-conversional moieties citaconic amide or cis-aconitic amide were developed for cytoplasmic protein delivery. The increase of the charge density on the protein cargo helped the stability of the PIC micelles without cross-linking, and the charge-conversion in endosomes induced the dissociation of the PIC micelles to result in efficient endosomal release (see picture).
authors.affiliation: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Yan
authors.initials: Y
authors.lastname: Lee
authors.forename: Takehiko
authors.initials: T
authors.lastname: Ishii
authors.forename: Horacio
authors.initials: H
authors.lastname: Cabral
authors.forename: Hyun Jin
authors.initials: HJ
authors.lastname: Kim
authors.forename: Ji-Hun
authors.initials: JH
authors.lastname: Seo
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Nishiyama
authors.forename: Hiroki
authors.initials: H
authors.lastname: Oshima
authors.forename: Kensuke
authors.initials: K
authors.lastname: Osada
authors.forename: Kazunori
authors.initials: K
authors.lastname: Kataoka
mesh_terms: D000577:Amides / Q000737:chemistry; D000818:Animals; D001224:Aspartic Acid / Q000737:chemistry; D045744:Cell Line, Tumor; D002949:Citraconic Anhydrides / Q000737:chemistry*; D045304:Cytochromes c / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D003593:Cytoplasm / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D006321:Heart; D006736:Horses; D006801:Humans; D007477:Ions / Q000737:chemistry; D008823:Micelles; D009206:Myocardium / Q000201:enzymology; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D000577:Amides; D002949:Citraconic Anhydrides; D004337:Drug Carriers; D007477:Ions; D008823:Micelles; D001224:Aspartic Acid; D011092:Polyethylene Glycols; D045304:Cytochromes c