title: Serum acute phase protein concentrations in dogs with autoimmune hemolytic anemia.
abstract: BACKGROUND
  Serial monitoring of acute phase protein (APP) concentrations in canine autoimmune hemolytic anemia (AIHA) has not been reported.
  
  
  OBJECTIVE
  Acute canine AIHA is accompanied by an acute phase response (APR) characterized by increased C-reactive protein (CRP) and alpha1-acid glycoprotein (AAG) concentrations and decreased albumin concentrations.
  
  
  METHODS
  Twenty-seven dogs with AIHA and 11 control dogs.
  
  
  METHODS
  Prospective, cohort study. CRP, AAG, and albumin concentrations, white blood cell (WBC) count, and packed cell volume (PCV) were determined at admission (day 1), every 48 hours until death or discharge, and on days 30, 90, 180, and 365.
  
  
  RESULTS
  Compared with controls, CRP and AAG concentrations were increased and albumin concentration was decreased in dogs with AIHA (days 1-7; P < .002) and normalized with disease stabilization (days 9-365; P > .05). APP concentrations on day 1 were not predictive of survival, duration of hospitalization, or number of blood transfusions (P= .153-.940). PCV correlated with APP concentrations over time (CRP r=-.600, AAG r=-.665, albumin r= .533; P < .0001) as did WBC count (CRP r= .253, AAG r= .486, albumin r=-.246; P < .006). Day 1 CRP concentration was lower for dogs that received corticosteroids before referral (115.3 microg/mL) compared with dogs that did not (191.2 microg/mL; P= .02).
  
  
  CONCLUSIONS
  An APR occurs in canine AIHA. Initial APP concentrations are not predictive of acute survival, correlate with hematologic markers of remission, and normalize rapidly with disease stabilization.
authors.affiliation: Department of Clinical Studies, University of Guelph, Guelph, ON, Canada.
authors.forename: K D
authors.initials: KD
authors.lastname: Mitchell
authors.forename: S A
authors.initials: SA
authors.lastname: Kruth
authors.forename: R D
authors.initials: RD
authors.lastname: Wood
authors.forename: B
authors.initials: B
authors.lastname: Jefferson
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000418:Albumins / Q000378:metabolism; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D004283:Dog Diseases / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009961:Orosomucoid / Q000378:metabolism; D012074:Remission Induction
chemical_list: D000209:Acute-Phase Proteins; D000418:Albumins; D007166:Immunosuppressive Agents; D009961:Orosomucoid; D002097:C-Reactive Protein