Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.
OBJECTIVE
To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA.


METHODS
In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort.


RESULTS
25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63).


CONCLUSIONS
Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA.
Feser
Marie
M
Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA.
Derber
Lezlie A
LA
Deane
Kevin D
KD
Lezotte
Dennis C
DC
Weisman
Michael H
MH
Buckner
Jane H
JH
Mikuls
Ted
T
O'Dell
James
J
Gregersen
Peter K
PK
Holers
V Michael
VM
Norris
Jill M
JM
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015415:Biomarkers; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology*; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
D015415:Biomarkers; D007136:Immunoglobulins; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D014807:Vitamin D; D012217:Rheumatoid Factor; C104450:25-hydroxyvitamin D