Antibodies against oxidized LDL and apolipoprotein E polymorphism in demented patients.
In serum of 114 patients with dementia and of 102 controls the level of IG class immunoglobulins directed against oxidized LDL and lipids were determined. In isolated DNA apolipoprotein E gene (APOE) polymorphism was identified. In some individuals very high levels of the antibodies were observed. exceeding the 90 percentile in the investigated group. The prevalence of very high anti-ox LDL antibodies level was significantly more frequent in the carriers of epsilon2 allele and less frequent in the carriers of epsilon4 allele.
Bednarska-Makaruk
Małgorzata
M
Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland. makaruk@ipin.edu.pl
Rodo
Maria
M
Graban
Ałła
A
Lojkowska
Wanda
W
Bochyńska
Anna
A
Ryglewicz
Danuta
D
Wehr
Hanna
H
D053329:Apolipoprotein E2 / Q000097:blood / Q000235:genetics; D053318:Apolipoprotein E3 / Q000097:blood / Q000235:genetics; D053327:Apolipoprotein E4 / Q000097:blood / Q000235:genetics; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D001323:Autoantibodies / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003704:Dementia / Q000097:blood / Q000235:genetics* / Q000276:immunology*; D005260:Female; D005838:Genotype; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D011110:Polymorphism, Genetic; D014280:Triglycerides / Q000097:blood
D053329:Apolipoprotein E2; D053318:Apolipoprotein E3; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D001323:Autoantibodies; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D002784:Cholesterol