title: Primary uncleansed 2D versus primary electronically cleansed 3D in limited bowel preparation CT-colonography. Is there a difference for novices and experienced readers?
abstract: The purpose of this study was to compare a primary uncleansed 2D and a primary electronically cleansed 3D reading strategy in CTC in limited prepped patients. Seventy-two patients received a low-fibre diet with oral iodine before CT-colonography. Six novices and two experienced observers reviewed both cleansed and uncleansed examinations in randomized order. Mean per-polyp sensitivity was compared between the methods by using generalized estimating equations. Mean per-patient sensitivity, and specificity were compared using the McNemar test. Results were stratified for experience (experienced observers versus novice observers). Mean per-polyp sensitivity for polyps 6 mm or larger was significantly higher for novices using cleansed 3D (65%; 95%CI 57-73%) compared with uncleansed 2D (51%; 95%CI 44-59%). For experienced observers there was no significant difference. Mean per-patient sensitivity for polyps 6 mm or larger was significantly higher for novices as well: respectively 75% (95%CI 70-80%) versus 64% (95%CI 59-70%). For experienced observers there was no statistically significant difference. Specificity for both novices and experienced observers was not significantly different. For novices primary electronically cleansed 3D is better for polyp detection than primary uncleansed 2D.
authors.affiliation: Department of Radiology Academic Medical Centre, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands. Ayso.devries@amc.uva.nl
authors.forename: Ayso H
authors.initials: AH
authors.lastname: de Vries
authors.forename: Marjolein H
authors.initials: MH
authors.lastname: Liedenbaum
authors.forename: Shandra
authors.initials: S
authors.lastname: Bipat
authors.forename: Roel
authors.initials: R
authors.lastname: Truyen
authors.forename: Iwo W O
authors.initials: IW
authors.lastname: Serlie
authors.forename: Rutger H
authors.initials: RH
authors.lastname: Cohen
authors.forename: Saskia G C
authors.initials: SG
authors.lastname: van Elderen
authors.forename: Anneke
authors.initials: A
authors.lastname: Heutinck
authors.forename: Oskar
authors.initials: O
authors.lastname: Kesselring
authors.forename: Wouter
authors.initials: W
authors.lastname: de Monyé
authors.forename: Lambertus
authors.initials: L
authors.lastname: te Strake
authors.forename: Tjeerd
authors.initials: T
authors.lastname: Wiersma
authors.forename: Jaap
authors.initials: J
authors.lastname: Stoker
mesh_terms: D000368:Aged; D002400:Cathartics / Q000008:administration & dosage; D023881:Colonography, Computed Tomographic / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007417:Intestinal Polyps / Q000000981:diagnostic imaging*; D007422:Intestines / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011361:Professional Competence; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D002400:Cathartics; D003287:Contrast Media