title: Lung function at 10 yr is not impaired by early childhood lower respiratory tract infections.
abstract: The causal relationship between lower respiratory tract infections (LRIs) in early life and reduced lung function later in childhood is unsettled. Therefore, we assessed whether LRIs the first 2 yr of life influenced lung function development from birth to school age. In the prospective Oslo birth cohort, 'the Environment and Childhood Asthma (ECA) study' lung function was measured at birth in 802 infants by tidal flow volume loops and in 664 infants by passive respiratory mechanics and half yearly questionnaires, including LRI questions, were completed until 2 yr of age. The present study includes 607 children with information about LRIs the first 2 yr of life and successfully forced expiratory flow (FEF) volume measurements at the 10-yr follow-up assessment. At 10 yr of age, FEF at 50% of forced vital capacity (FEF(50)) (mean 95% confidence interval) was reduced in children with at least one bronchiolitis (85.0, 80.6-89.5, p = 0.020) or bronchitis (86.2, 82.6-89.8, p = 0.030) or > or =3 LRIs (83.4, 78.1-88.8, p = 0.017) when compared with no LRIs (90.6, 88.8-92.5) by 2 yr of life. The effects were significant in girls only when stratifying for gender. Among girls with later bronchiolitis compliance of the respiratory system (3.64, 3.17-4.10 vs. 4.18, 3.98-4.37, p = 0.031) and the ratio of time to peak tidal expiratory flow to total expiratory time (t(PTEF)/t(E)) measured at birth was significantly reduced (0. 26, 0.23-0.29 vs. 0.32, 0.30-0.33, p = 0.005) when compared with children with no LRIs. Change in lung function from birth (by t(PTEF)/t(E)) to 10 yr of age was not significantly associated with LRIs the first 2 yr of life, and LRIs by 2 yr of life were not significantly associated with lung function at 10 yr of age in regression analyses including lung function at birth and other possible predictors of lung function at 10 yr. In our study, LRIs during the first 2 yr of life did not impair lung function development from birth until 10 yr of age.
authors.affiliation: Division of Woman and Child, Department of Pediatrics, Ullevål University Hospital, Oslo N-0407, Norway. geir.haland@medisin.uio.no
authors.forename: Geir
authors.initials: G
authors.lastname: Håland
authors.forename: Karin Cecilie
authors.initials: KC
authors.lastname: Lødrup Carlsen
authors.forename: Petter
authors.initials: P
authors.lastname: Mowinckel
authors.forename: Monica Cheng
authors.initials: MC
authors.lastname: Munthe-Kaas
authors.forename: Chandra Sekhar
authors.initials: CS
authors.lastname: Devulapalli
authors.forename: Sveinung
authors.initials: S
authors.lastname: Berntsen
authors.forename: Kai-Håkon
authors.initials: KH
authors.lastname: Carlsen
mesh_terms: D001991:Bronchitis / Q000453:epidemiology / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D016014:Linear Models; D008168:Lung / Q000502:physiology*; D008297:Male; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000503:physiopathology*; D011795:Surveys and Questionnaires