Regulation of mammalian pre-mRNA splicing.
In eukaryotes, most protein-coding genes contain introns which are removed by precursor messenger RNA (pre-mRNA) splicing. Alternative splicing is a process by which multiple messenger RNAs (mRNAs) are generated from a single pre-mRNA, resulting in functionally distinct proteins. Recent genome-wide analyses of alternative splicing indicated that in higher eukaryotes alternative splicing is an important mechanism that generates proteomic complexity and regulates gene expression. Mis-regulation of splicing causes a wide range of human diseases. This review describes the current understanding of pre-mRNA splicing and the mechanisms that regulate mammalian pre-mRNA splicing. It also discusses emerging directions in the field of alternative splicing.
Hui
JingYi
J
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. jyhui@sibs.ac.cn
D017398:Alternative Splicing; D000818:Animals; D005091:Exons; D005544:Forecasting; D005786:Gene Expression Regulation; D006801:Humans; D007438:Introns; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D008957:Models, Genetic; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism*; D012326:RNA Splicing; D015398:Signal Transduction
D012322:RNA Precursors