title: Prevalence of joint replacement surgery in rheumatoid arthritis patients: cross-sectional analysis in a large observational cohort in Japan.
abstract: The purpose of this study was to describe the prevalence of total joint arthroplasty (TJA) in Japanese rheumatoid arthritis (RA) patients undergoing conventional drug treatment in a large observational cohort in Japan. A total of 5,177 RA patients were studied for the prevalence of TJA, who were enrolled in the NinJa database during the fiscal year of 2006. The cases of 2,695 RA patients with more than ten years of disease duration were extracted and subjected to further analysis. The prevalence of TJA increased in accordance with the disease duration, and the prevalence was markedly increased after ten years. Among the 2,695 patients with more than ten years of disease duration, 1,431 TJAs were performed in 645 (24.6%) patients. The patients with TJA had higher disease activity than those without TJA. In this cross-sectional study, TJAs were performed in approximately a quarter of the Japanese RA patients with more than ten years of disease duration. The result showed that patients with higher disease activity required TJA.
authors.affiliation: Nishino Clinic Orthopedics and Rheumatology, Nishigaoka, Kita-ku, Tokyo, Japan. west@kitanet.ne.jp
authors.forename: Jinju
authors.initials: J
authors.lastname: Nishino
authors.forename: Sakae
authors.initials: S
authors.lastname: Tanaka
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Matsui
authors.forename: Toshihito
authors.initials: T
authors.lastname: Mori
authors.forename: Keita
authors.initials: K
authors.lastname: Nishimura
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Eto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kaneko
authors.forename: Koichiro
authors.initials: K
authors.lastname: Saisho
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yasuda
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Chiba
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yoshinaga
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Saeki
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Seki
authors.forename: Shigeto
authors.initials: S
authors.lastname: Tohma
mesh_terms: D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000601:surgery*; D019643:Arthroplasty, Replacement / Q000706:statistics & numerical data*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D018501:Antirheumatic Agents