The role of the transcriptional regulator snail in cell detachment, reattachment and migration.
In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues and attach to a second site. The transcription factor snail is an important mediator of epithelial-mesenchymal transitions and is involved in tumor progression. Recent data have provided evidence for a requirement for snail expression in metastatic dissemination. Although very little is known about the molecular mechanisms governing metastatic dissemination, we review the possible roles of snail expression in this process. We also review the regulation of snail expression.
Haraguchi
Misako
M
Department of Biochemistry and Molecular Biology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan. haraguci@m3.kufm.kagoshima-u.ac.jp
D017209:Apoptosis; D002448:Cell Adhesion / Q000235:genetics; D002465:Cell Movement; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D000071250:Snail Family Transcription Factors; D014157:Transcription Factors / Q000378:metabolism*
D000071250:Snail Family Transcription Factors; D014157:Transcription Factors