Contribution of fat-free mass and fat mass to bone mineral density among reproductive-aged women of white, black, and Hispanic race/ethnicity.
The objective of the study was to evaluate the contribution of fat-free mass (FFM) and fat mass (FM) to bone mineral density (BMD) and bone mineral apparent density (BMAD) among reproductive-aged women. Dual-energy X-ray absorptiometry scans were performed on 708 healthy black, white, and Hispanic women, 16-33 yr of age. The independent effect of FFM and FM on BMD and BMAD and the interaction of body composition measurements with race/ethnicity and age, were evaluated. FFM correlated more strongly than FM with BMD at the lumbar spine (r=0.52 vs r=0.39, p<0.01) and the femoral neck (r=0.54 vs r=0.41, p<0.01). There was a significant positive association between bone density measures [ln(BMD) and ln(BMAD)] and both ln(FFM) and ln(FM). The association of FFM with spinal BMD was stronger in 16-24-yr-old women than in 25-33-yr-old women (p<0.006). The effect of FFM on femoral neck BMD was greater in blacks (p<0.043) than Hispanics, whereas the effect of FM on spinal BMD was less (p<0.047). Both FM and FFM are important contributors to bone density although the balance of importance is slightly different between BMD and BMAD.
Berenson
Abbey B
AB
Department of Obstetrics & Gynecology, Center for Interdisciplinary Research in Women's Health, The University of Texas Medical Branch, Galveston, TX 77555-0587, USA. abberens@utmb.edu
Breitkopf
Carmen Radecki
CR
Newman
Jennifer L
JL
Rahman
Mahbubur
M
D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D044383:Black People / Q000706:statistics & numerical data*; D001823:Body Composition; D015519:Bone Density; D005260:Female; D006630:Hispanic or Latino / Q000706:statistics & numerical data*; D006801:Humans; D016014:Linear Models; D017697:Premenopause; D044465:White People / Q000706:statistics & numerical data*