title: Vancomycin use during left ventricular assist device support.
abstract: We reviewed the frequency and duration of vancomycin use during 93 left ventricular assist device placements. Vancomycin prophylaxis was administered for a mean duration (+/- standard deviation) of 10.5 +/- 11 days. Empirical vancomycin use was frequent, with a mean duration (+/- standard deviation) of therapy of 9.8 +/- 9 days (median, 8 days) given during 81 (87%) of the implantations. The most common indications for empirical vancomycin treatment were isolated leukocytosis or driveline drainage. Strategies to improve vancomycin use during left ventricular assist device support should be considered.
authors.affiliation: Department of Pharmacy Services, University of Michigan Health System and College of Pharmacy, Ann Arbor, Michigan 48109-0008, USA.
authors.forename: Rachel F
authors.initials: RF
authors.lastname: Eyler
authors.forename: Simona O
authors.initials: SO
authors.lastname: Butler
authors.forename: Paul C
authors.initials: PC
authors.lastname: Walker
authors.forename: Daryl D
authors.initials: DD
authors.lastname: DePestel
authors.forename: Martinus T
authors.initials: MT
authors.lastname: Spoor
authors.forename: Francis D
authors.initials: FD
authors.lastname: Pagani
authors.forename: Preeti N
authors.initials: PN
authors.lastname: Malani
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis / Q000706:statistics & numerical data; D005260:Female; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D014640:Vancomycin / Q000627:therapeutic use*; D018487:Ventricular Dysfunction, Left / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin