Lysyl oxidases in mammalian development and certain pathological conditions.
Lysyl oxidase (LOX) catalyzes the oxidation of the side chain of a peptidyl lysine converting specific lysine and hydroxylysine residues of alpha-aminoadipic-delta-semialdehydes, which form covalent crosslinks in collagens and elastin. Five different but closely related lysyl oxidase isoenzymes have been identified to date, and they seem to have overlapping functions in many tissues. Modification of the extracellular matrix by lysyl oxidases has been shown to be a critical contributor to the development of various organs and certain pathological conditions.
Mäki
Joni M
JM
Oulu Centre for Cell-Matrix Research, Biocenter Oulu, University of Oulu, Oulu, Finland. joni.maki@oulu.fi
D000594:Amino Acid Oxidoreductases / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000209:etiology; D002319:Cardiovascular System / Q000201:enzymology / Q000254:growth & development; D006801:Humans; D008322:Mammals; D008954:Models, Biological; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology; D008249:Protein-Lysine 6-Oxidase / Q000235:genetics / Q000378:metabolism*; D012137:Respiratory System / Q000201:enzymology / Q000254:growth & development
D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human; D008249:Protein-Lysine 6-Oxidase