[The correlation between interleukin-1 receptor antagonist genotype and coronary heart disease in patients with chronic periodontitis].
OBJECTIVE
To investigate the correlation between interleukin-1 receptor antagonist (IL-1ra) genotype and chronic periodontitis in patients with coronary heart disease.


METHODS
Genomic DNA was obtained from buccal swabs in 86 patients with coronary heart disease,of which 45 patients with chronic periodontitis, the other without chronic periodontitis. Genotypes of IL-1RN intron 2 VNTR were analyzed by SSP-PCR method. Then the differences in distribution of each genotype were analyzed with SPSS 13.0 software package.


RESULTS
A significant over-representation of IL-1 RN intron 2 VNTR allele 2 was found in patients with coronary heart disease and chronic periodontitis group (chi(2)=4.960,P=0.026).


CONCLUSIONS
IL-1RN intron 2 VNTR allele 2 may be a risk indicator for the susceptibility of chronic periodontitis in patients with coronary heart disease.
Chu
Meng
M
Department of Stomatology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
Zhong
Liang-jun
LJ
Li
Sheng-biao
SB
Yang
Ke
K
Jiang
Han
H
D000483:Alleles; D055113:Chronic Periodontitis; D003327:Coronary Disease; D005838:Genotype; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D012307:Risk Factors
D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1