title: [The role of biology in the diagnosis of cerebrospinal fluid leaks].
abstract: Cerebrospinal fluid leakage is a rare but critical condition with a substantial risk of intracranial infection, therefore its diagnosis and treatment is of major importance. CSF leakage diagnostic can be a challenging problem. Nephelometric measurement of beta-trace protein in the liquorrhoea is a non-invasive and fast method that can be used for CSF leakage diagnosis. It should kept in mind, however, that the cut-off of 1.1 mg/L is not suitable for patients with bacterial meningitis and those with a reduced glomerular filtration rate. Complementary use of beta-trace protein assay and beta2-transferrin detection is therefore recommended.
authors.affiliation: Laboratoire de biologie, Centre hospitalier Sainte-Anne, Paris, France. k.tabaouti@ch-sainte-anne.fr
authors.forename: K
authors.initials: K
authors.lastname: Tabaouti
authors.forename: L
authors.initials: L
authors.lastname: Kraoul
authors.forename: L
authors.initials: L
authors.lastname: Alyousef
authors.forename: G Abi
authors.initials: GA
authors.lastname: Lahoud
authors.forename: S Brovedani
authors.initials: SB
authors.lastname: Rousset
authors.forename: F
authors.initials: F
authors.lastname: Lancelin
authors.forename: E
authors.initials: E
authors.lastname: Mouchet
authors.forename: M-L
authors.initials: ML
authors.lastname: Piketty
mesh_terms: D002558:Cerebrospinal Fluid Otorrhea / Q000209:etiology; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology; D002560:Cerebrovascular Circulation; D006801:Humans; D019746:Intramolecular Oxidoreductases / Q000032:analysis*; D054834:Lipocalins / Q000032:analysis*; D008581:Meningitis / Q000209:etiology; D009391:Nephelometry and Turbidimetry; D015203:Reproducibility of Results; D013353:Subdural Effusion / Q000175:diagnosis* / Q000503:physiopathology; D014168:Transferrin / Q000378:metabolism
chemical_list: D054834:Lipocalins; D014168:Transferrin; D019746:Intramolecular Oxidoreductases; C022466:prostaglandin R2 D-isomerase