Efficient fragment coupling approaches toward large oxacalix[n]arenes (n = 6, 8).
The first rational, stepwise synthesis of enlarged oxacalix[n]arenes (n > 4) is described. Variously substituted oxacalix[3]arene[3]pyrimidines were prepared rather selectively by a straightforward [3 + 3] fragment coupling approach after a thorough search for the optimum nucleophilic aromatic substitution conditions. Similar procedures also allowed facile synthesis of unsymmetrical oxacalix[4]- and oxacalix[8]arenes.
Van Rossom
Wim
W
Molecular Design and Synthesis, Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, 3001 Leuven, Belgium.
Ovaere
Margriet
M
Van Meervelt
Luc
L
Dehaen
Wim
W
Maes
Wouter
W