title: Selective monoarylation of acetate esters and aryl methyl ketones using aryl chlorides.
abstract: Simple, efficient procedures for the monoarylation of acetate esters and aryl methyl ketones using aryl chlorides are presented. Previously, no general method was available to ensure the highly selective monoarylation of these classes of substrates using aryl chlorides. Using palladium precatalysts recently reported by our group, these reactions are easily accomplished under mild conditions that tolerate a wide array of heterocyclic substrates.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachussetts 02139, USA.
authors.forename: Mark R
authors.initials: MR
authors.lastname: Biscoe
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D000085:Acetates / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D004952:Esters; D006843:Hydrocarbons, Chlorinated; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D000085:Acetates; D004952:Esters; D006843:Hydrocarbons, Chlorinated; D007659:Ketones; D010165:Palladium