A reply to Dembic: on an end to the beginning of misunderstanding the immune response.
We all agree that dealing with the complexity and volume of the data necessitates the use of computer modelling. This in turn requires a heuristic conceptual framework to guide this modelling. The first attempt to do this by Cohn has been criticized by Dembic as being severely lacking. This commentary deals with his criticism of the framework to show why Cohn's postulates, in fact, remain unchallenged.
Cohn
M
M
Conceptual Immunology Group, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. cohn@salk.edu
D000818:Animals; D003198:Computer Simulation; D006801:Humans; D007107:Immune System / Q000502:physiology*; D018448:Models, Immunological