title: Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis.
abstract: Type A chronic atrophic gastritis (CAG) is increased in type 1 diabetic patients (DM1). To address this issue, we determined and analyzed the number of peripheral blood regulatory T cells (Tregs) in 15 DM1-CAG patients, 15 DM1 patients without associated autoantibodies (DM1) and 15 healthy controls by flow cytometry and compared gastric Tregs expression (CD4+Foxp3+/CD4+) in DM1-CAG patients with that observed in 10 control Helicobacter pylori CAG-infected biopsies. The percentage of peripheral Tregs was higher in DM1-CAG patients compared to DM1 and controls (CD4+Foxp3+: 7.67 +/- 1.91% vs. 5.38 +/- 1.57% and 5.65 +/- 1.76%, P < 0.001, respectively), with no differences between DM1 and controls. Gastric mucosal Tregs were higher in H. pylori CAG than in DM1-CAG patients (31.31 +/- 5.52% vs. 7.68 +/- 3.70%; P < 0.001). Data suggest that Tregs are stimulated in patients with more than one autoimmune disease (DM1 + CAG) in an ineffectual attempt to control autoimmune response and that the number of Tregs in gastric mucosa implicated in the chronification of gastritis differs according to the etiology.
authors.affiliation: Department of Endocrinology and Nutrition, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Ctra Canyet s/n, Badalona, 08916 Barcelona, Spain. nalonso.germanstrias@gencat.cat
authors.forename: Núria
authors.initials: N
authors.lastname: Alonso
authors.forename: María Jesús
authors.initials: MJ
authors.lastname: Martínez-Arconada
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Granada
authors.forename: Berta
authors.initials: B
authors.lastname: Soldevila
authors.forename: Ana
authors.initials: A
authors.lastname: Cantón
authors.forename: José Luis
authors.initials: JL
authors.lastname: Mate
authors.forename: Anna
authors.initials: A
authors.lastname: Sanmartí
authors.forename: Eva María
authors.initials: EM
authors.lastname: Martínez-Cáceres
mesh_terms: D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000150:complications / Q000276:immunology / Q000473:pathology; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000276:immunology* / Q000473:pathology; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D005753:Gastric Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D005757:Gastritis, Atrophic / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000473:pathology*; D055815:Young Adult
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors