Polyphenols with antiulcerogenic action from aqueous decoction of mango leaves (Mangifera indica L.).
This study was designed to determine the gastroprotective effect of a Mangifera indica leaf decoction (AD), on different experimental models in rodents. The administration of AD up to a dose of 5 g/kg (p.o.) did not produce any signs or symptoms of toxicity in the treated animals, while significantly decreasing the severity of gastric damage induced by several gastroprotective models. Oral pre-treatment with AD (250, 500 or 1000 mg/kg) in mice and rats with gastric lesions induced by HCl/ethanol, absolute ethanol, non-steroidal anti-inflammatory drug (NSAID) or stress-induced gastric lesions resulted in a significant decrease of said lesions. Phytochemical analyses of AD composition demonstrated the presence of bioactive phenolic compounds that represent 57.3% of total phenolic content in this extract. Two main phenolic compounds were isolated, specifically mangiferin (C-glucopyranoside of 1,3,6,7-tetrahydroxyxanthone) and C-glucosyl-benzophenone (3-C-beta-D-glucopyranosyl-4',2,4,6-tetrahydroxybenzophenone). These findings indicate the potential gastroprotective properties of aqueous decoction from M. indica leaves.
Severi
Juliana Aparecida
JA
Pharmacos and Drugs Department, Pharmaceutical Sciences Faculty, São Paulo State University-UNESP, UNESP, Araraquara, SP, Brazil. juseveri@yahoo.com.br
Lima
Zeila Pinheiro
ZP
Kushima
Hélio
H
Brito
Alba Regina Monteiro Souza
AR
Santos
Lourdes Campaner dos
LC
Vilegas
Wagner
W
Hiruma-Lima
Clélia Akiko
CA
D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001577:Benzophenones; D004195:Disease Models, Animal; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D031022:Mangifera / Q000737:chemistry*; D051379:Mice; D010636:Phenols / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D059808:Polyphenols; D051381:Rats; D012074:Remission Induction; D013276:Stomach Ulcer / Q000188:drug therapy / Q000209:etiology; D014867:Water; D044004:Xanthones
D000897:Anti-Ulcer Agents; D001577:Benzophenones; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D044004:Xanthones; D014867:Water; C013592:mangiferin