Microparticles, thrombosis and cancer.
Microvesicles comprised of exosomes and microparticles are shed from both normal and malignant cells upon cell activation or apoptosis. Microvesicles promote clot formation, mediate pro-inflammatory processes, facilitate cell-to-cell interactions, transfer proteins and mRNA to cells, and induce cell signalling. Microparticles bearing tissue factor play a central role in coagulation initiation and thrombus formation. This chapter will review earlier studies which focus on the role of procoagulant microvesicles in cancer thrombogenicity, and discuss the effects of microvesicles on vascular cell dysfunction and angiogenesis. In addition, this chapter will present new findings which characterize the haemostatic balance of microparticles, and suggest a method that may potentially serve to predict a state of hypercoagulability in cancer patients. This chapter highlights the interplay between microvesicles, coagulation factors and cancer.
Aharon
Anat
A
Thrombosis and Haemostasis Research Laboratory, Rambam Health Care Campus, P.O.B 9602, Haifa 31096, Israel.
Brenner
Benjamin
B
D017209:Apoptosis; D001779:Blood Coagulation Factors / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000276:immunology / Q000473:pathology*; D006801:Humans; D009369:Neoplasms / Q000150:complications* / Q000473:pathology*; D013927:Thrombosis / Q000150:complications* / Q000473:pathology*
D001779:Blood Coagulation Factors