Models of haematopoiesis: seeing the wood for the trees.
Many models of haematopoiesis dictate that haematopoietic stem cells make an early and irrevocable choice between lymphoid and myeloid cell fates. However, recent data show that intermediate progenitors have both lymphoid and myeloid potential, thereby refuting early theories and leading to a lack of consensus in the field. In this Opinion article we present a simple pairwise relationships model of cell fate determination that does not depend on the underlying developmental branch points that in other models dictate a preferred route (or routes) to a particular cell fate.
Ceredig
Rhodri
R
Regenerative Medicine Institute, National Centre for Biomedical Engineering Science, Department of Physiology, National University of Ireland, Galway, Ireland. rod.ceredig@nuigalway.ie
Rolink
Antonius G
AG
Brown
Geoffrey
G
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D019070:Cell Lineage; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D054503:Lymphoid Progenitor Cells / Q000166:cytology / Q000502:physiology; D008954:Models, Biological; D023461:Myeloid Progenitor Cells / Q000166:cytology / Q000502:physiology; D054448:Precursor Cells, B-Lymphoid / Q000166:cytology / Q000502:physiology; D054504:Precursor Cells, T-Lymphoid / Q000166:cytology / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology
D014157:Transcription Factors