[Determining the alveolar component of nitric oxide in exhaled air: procedures and reference values for healthy persons].
Nitric oxide (NO) production has been described using a 2-compartment model for the synthesis and movement of NO in both the alveoli and the airways. The alveolar concentration of NO (Ca(NO)), an indirect marker of the inflammatory state of the distal portions of the lung, can be deduced through exhalation at multiple flow rates. Our objective was to determine reference values for Ca(NO). The fraction of exhaled NO (Fe(NO)) was measured in 33 healthy individuals at a rate of 50mL/s; the subjects then exhaled at 10, 30, 100, and 200mL/s to calculate Ca(NO). A chemiluminescence analyzer (NIOX Aerocrine) was used to perform the measurements. The mean (SD) Fe(NO) was 15 (6)ppb. The mean Ca(NO) was 3.04 (1.30)ppb. These values of Ca(NO) measured in healthy individuals will allow us to analyze alveolar inflammatory behavior in respiratory and systemic processes.
Fortuna
Ana María
AM
Unidad de Función Pulmonar, Departamento de Neumología, Hospital de la Santa Creu i Sant Pau, Facultad de Medicina, Universidad Autónoma de Barcelona, Barcelona, España. afortuna@santpau.cat
Balleza
Marco
M
Calaf
Núria
N
González
Mercedes
M
Feixas
Teresa
T
Casan
Pere
P
D000328:Adult; D001944:Breath Tests / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D009569:Nitric Oxide / Q000032:analysis* / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000378:metabolism; D012016:Reference Values
D009569:Nitric Oxide