The iron trap: iron, malaria and anemia at the mother-child interface.
Iron deficiency causes anemia, but prevents malaria for unknown reasons, thus hindering iron supplementation programs for mothers and children. Iron homeostasis is tightly regulated, including at the mother-fetus interface where iron-malaria relationships are complex. Improved iron status assays, and understanding of malaria protection mechanisms, are needed to manage these disorders.
Friedman
Jennifer F
JF
Department of Pediatrics, Brown University, Providence, RI, USA.
Kurtis
Jonathan D
JD
Kabyemela
Edward R
ER
Fried
Michal
M
Duffy
Patrick E
PE
D000740:Anemia / Q000209:etiology*; D005260:Female; D006801:Humans; D000090463:Iron Deficiencies; D008288:Malaria / Q000517:prevention & control*; D011247:Pregnancy