title: Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita.
abstract: Phytochemical studies of the chloroform soluble fraction of Dioscorea opposita resulted in the isolation of four new compounds, 3,5-dihydroxy-4-methoxybibenzyl (1), 3,3',5-trihydroxy-2'-methoxybibenzyl (2), 10,11-dihydro-dibenz[b,f]oxepin-2,4-diol (3), and 10,11-dihydro-4-methoxy-dibenz[b,f]oxepin-2-ol (4), together with an additional fifteen known compounds. The structures of 1-4 were elucidated by spectroscopic methods including 2D NMR. All of the nineteen isolated compounds were tested in the DPPH, superoxide anion radical scavenging assays and cyclooxygenases (COXs) inhibition assay. Of those, compounds 7, 9, 11, 12, 13, 15 and 18 exhibited radical scavenging activities and compounds 2, 3, 8, 13, 15 and 16 showed selective inhibitory activities against COX-2.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, South Korea.
authors.forename: Min Hye
authors.initials: MH
authors.lastname: Yang
authors.forename: Kee Dong
authors.initials: KD
authors.lastname: Yoon
authors.forename: Young-Won
authors.initials: YW
authors.lastname: Chin
authors.forename: Ju Hyun
authors.initials: JH
authors.lastname: Park
authors.forename: Jinwoong
authors.initials: J
authors.lastname: Kim
mesh_terms: D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry* / Q000378:metabolism; D003990:Dibenzoxepins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D027742:Dioscorea / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D003990:Dibenzoxepins; D016166:Free Radical Scavengers; D010636:Phenols; D010936:Plant Extracts; D013267:Stilbenes