title: The future of endocannabinoid-oriented clinical research after CB1 antagonists.
abstract: BACKGROUND
  Great interest has been shown by the medical community and the public in the cannabinoid CB(1) receptor antagonists, such as rimonabant, for treatment of obesity, metabolic syndrome, and possibly drug addiction.
  
  
  CONCLUSIONS
  This novel class of drug has therapeutic potential for other disorders, as the endocannabinoid system is involved in various health conditions. However, rimonabant, the first clinically available member of this class of drugs, has been linked to increased risk of anxiety, depression, and suicidality. Due to those risks, the European Medicines Agency called for its withdrawal from the market in October, 2008. Shortly after this decision, several pharmaceutical companies (Sanofi-aventis, Merck, Pfizer, Solvay) announced that they would stop further clinical research on this class of drug. Here, we provide an overview of those events and make several suggestions for continuing such clinical research, while safeguarding the safety of patients and clinical trial subjects.
authors.affiliation: Translational Addiction Research Laboratory, Centre for Addiction and Mental Health, University of Toronto, 33 Russell Street, M5S 2S1, Toronto, ON, Canada. bernard_lefoll@camh.net
authors.forename: Bernard
authors.initials: B
authors.lastname: Le Foll
authors.forename: David A
authors.initials: DA
authors.lastname: Gorelick
authors.forename: Steven R
authors.initials: SR
authors.lastname: Goldberg
mesh_terms: D063385:Cannabinoid Receptor Modulators / Q000378:metabolism*; D002986:Clinical Trials as Topic; D063388:Endocannabinoids; D006801:Humans; D009765:Obesity / Q000188:drug therapy; D043884:Receptor, Cannabinoid, CB1 / Q000037:antagonists & inhibitors*
chemical_list: D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D043884:Receptor, Cannabinoid, CB1