Tyrosine kinases and their substrates in B lymphocytes.
Gene-targeting experiments have highlighted the importance of the intracellular protein tyrosine kinases, Lyn, Syk, and Btk, in B-cell receptor-mediated phospholipase C gamma 2 and phosphoinositide 3-kinase activation. In linking such tyrosine kinases with effector enzymes, an important role has emerged for adapter molecules. Adapter proteins nucleate formation of distinct signaling complexes in a specific location within the cell and facilitate the interaction between these signaling components in this particular subcellular compartment, which, in turn, contribute to the qualitative and quantitative control of B-cell signaling.
Kurosaki
Tomohiro
T
Laboratory of Lymphocyte Differentiation, WPI Immunology Frontier Research Center, Osaka University, Suita, Osaka, Japan. kurosaki@rcai.riken.jp
Hikida
Masaki
M
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000201:enzymology* / Q000276:immunology*; D002454:Cell Differentiation; D006801:Humans; D008213:Lymphocyte Activation; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell; D015398:Signal Transduction
D011947:Receptors, Antigen, B-Cell; D011505:Protein-Tyrosine Kinases