Serum cholesterol LDL and 90-day mortality in patients with intracerebral hemorrhage.
OBJECTIVE
Prognostic significance of low-density lipoprotein cholesterol (LDL-C) in intracranial hemorrhage (ICH) is unclear. The objective of this study was to determine the association between LDL-C and mortality in ICH.


METHODS
Consecutive patients (n=88) presenting with ICH were included in the study. Lipid profile was obtained during the first hours after admission. We analyzed the impact of LDL-C on 90-day mortality using the Hazard Rate (HR) crude, analysis crude for trend by Mantel-Haenszel Test, Multiple Cox Proportional Hazards model, and analysis of survival curves. Association between LDL-C and severity markers of ICH were explored using Spearman correlation coefficient.


RESULTS
Low LDL-C levels were independently associated with death after intracranial hemorrhage (HR=3.07 (95% CI:1.04 to 9.02; P=0.042) in multivariable analysis after controlling for confounding factors. Analysis for trend showed a significant association (Xt=-2.144; P=0.032) by Mantel-Haenszel Test. Spearman analysis showed no correlation between LDL-C and variables that are markers of ICH severity: NIH score (r=-0.091; P=0.400), GCS score (r=0.136; P=0.207), ICH volume (r=0.140; P=0.192), and length of stay (r=-0.111; P=0.308).


CONCLUSIONS
Low levels of LDL-C are independently associated with an increased risk of death in patients with brain hemorrhage. We have not found evidences that the levels of LDL-C can act as a biological marker of severity.
Ramírez-Moreno
José María
JM
Department of Neurology, Section of Neurology, Infanta Cristina Universitary Hospital, Badajoz, Spain. jramirezm@meditex.es
Casado-Naranjo
Ignacio
I
Portilla
Juan Carlos
JC
Calle
María Luisa
ML
Tena
David
D
Falcón
Alfonso
A
Serrano
Ana
A
D000368:Aged; D000704:Analysis of Variance; D002543:Cerebral Hemorrhage / Q000097:blood* / Q000000981:diagnostic imaging / Q000401:mortality*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016016:Proportional Hazards Models; D011446:Prospective Studies; D011859:Radiography; D012307:Risk Factors; D013534:Survival; D016896:Treatment Outcome
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL