Ten-year incidence and risk factors of bone fractures in a cohort of treated HIV1-infected adults.
In the ANRS CO8 APROCO-COPILOTE cohort of patients treated with combination antiretroviral therapy since 1997-1999, the incidence density of bone fractures was 3.3 for 1000 patient-years [95% confidence interval (CI) = 2.0-4.6]. The rate was 2.9-fold (95% CI = 1.3-6.5) higher among patients with excessive alcohol consumption and 3.6-fold (95% CI = 1.6-8.1) higher in those with hepatitis C virus (HCV) coinfection. Specific monitoring of HCV/HIV-coinfected patients and active promotion of alcohol cessation should be recommended for the prevention of bone fractures.
Collin
Fidéline
F
INSERM U 897, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, case 11, 33076 Bordeaux Cedex, France. Fideline.Collin@isped.u-bordeaux2.fr
Duval
Xavier
X
Le Moing
Vincent
V
Piroth
Lionel
L
Al Kaied
Firas
F
Massip
Patrice
P
Villes
Virginie
V
Chêne
Geneviève
G
Raffi
François
F
D000328:Adult; D000428:Alcohol Drinking / Q000453:epidemiology*; D015331:Cohort Studies; D004359:Drug Therapy, Combination; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology*; D005602:France / Q000453:epidemiology; D015658:HIV Infections / Q000453:epidemiology*; D015497:HIV-1; D006526:Hepatitis C / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D012367:RNA, Viral; D012307:Risk Factors
D012367:RNA, Viral