Peroxiredoxin I is overexpressed in oncocytic lesions of salivary glands.
BACKGROUND
Oncocytic lesions, particularly frequent in the salivary glands, are characterized by cells with an atypical accumulation of mitochondria. This accumulation has been recognized as a compensatory mechanism to intrinsic functional defects of these organelles, resulting in energy production impairment and increased generation of reactive oxygen species (ROS), including hydrogen peroxide (H(2)O(2)). Peroxiredoxin I (Prx I) is a H(2)O(2) scavenging protein and the expression of its yeast homolog was reported to be influenced by mitochondrial function.


METHODS
In this study, we evaluated Prx I expression in oncocytic lesions of salivary glands by immunohistochemistry.


RESULTS
Our results showed that Prx I is overexpressed in oncocytes regardless of the salivary gland lesion where they appear.


CONCLUSIONS
These results suggest that Prx I expression in oncocytes is related to its ability to decompose mitochondrial-derived H(2)O(2) and that it could provide to the cells a protective role in an environment that, by continuously producing potential DNA-damaging ROS, predisposes to genome instability and cellular transformation.
Demasi
Ana P D
AP
Department of Oral Pathology, São Leopoldo Mandic Research Center, SP, Brazil. demasiap@gmail.com
Furuse
Cristiane
C
Altemani
Albina
A
Junqueira
José L C
JL
Oliveira
Paulo R G
PR
Araújo
Vera C
VC
D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology; D000235:Adenolymphoma / Q000201:enzymology / Q000473:pathology; D018249:Adenoma, Oxyphilic / Q000201:enzymology / Q000473:pathology; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D018277:Carcinoma, Mucoepidermoid / Q000201:enzymology / Q000473:pathology; D016166:Free Radical Scavengers / Q000032:analysis; D015971:Gene Expression Regulation, Enzymologic; D016586:Granular Cell Tumor / Q000201:enzymology / Q000473:pathology; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis; D006965:Hyperplasia; D008247:Lysosomes / Q000473:pathology; D008679:Metaplasia; D008928:Mitochondria / Q000473:pathology; D024862:Oxyphil Cells / Q000201:enzymology* / Q000473:pathology; D054464:Peroxiredoxins / Q000032:analysis*; D017382:Reactive Oxygen Species / Q000032:analysis; D012468:Salivary Gland Neoplasms / Q000201:enzymology / Q000473:pathology; D012469:Salivary Glands / Q000201:enzymology* / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology
D000975:Antioxidants; D015415:Biomarkers; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D054464:Peroxiredoxins