title: Replication studies for the association of PSMA6 polymorphism with coronary artery disease in East Asian populations.
abstract: Coronary artery disease (CAD) has become a major health problem in many countries because of its increasing prevalence and high mortality. Recently, an association of a functional sequence variation, -8C>G, in the human proteasome subunit alpha type 6 gene (PSMA6) with the susceptibility to CAD was reported. To validate the association, we investigated a total of 1330 cases and 2554 controls from Japanese and Korean populations for PSMA6 genotypes, and no evidence of the association was obtained in both Japanese (odds ratio (OR)=1.03, 95% confidence interval (CI); 0.90-1.19, P=0.66, allele count model) and Korean populations (OR=1.00, 95% CI; 0.86-1.17, P=0.95, allele count model). However, when a meta-analysis of data from this study and previously reported six replication studies was done, OR was 1.08 for the G allele (95% CI; 1.02-1.14, P=0.0057), suggesting that the contribution of PSMA6 to CAD was not large enough to be readily replicated. Further studies are required to establish the contribution of this variant in the susceptibility to CAD.
authors.affiliation: Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo, Japan.
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Hinohara
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Nakajima
authors.forename: Taishi
authors.initials: T
authors.lastname: Sasaoka
authors.forename: Motoji
authors.initials: M
authors.lastname: Sawabe
authors.forename: Bok-Soo
authors.initials: BS
authors.lastname: Lee
authors.forename: Jimin
authors.initials: J
authors.lastname: Ban
authors.forename: Jeong-Euy
authors.initials: JE
authors.lastname: Park
authors.forename: Toru
authors.initials: T
authors.lastname: Izumi
authors.forename: Akinori
authors.initials: A
authors.lastname: Kimura
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007564:Japan; D007723:Korea; D008297:Male; D015201:Meta-Analysis as Topic; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D046988:Proteasome Endopeptidase Complex / Q000235:genetics*; D015203:Reproducibility of Results
chemical_list: C465641:PSMA6 protein, human; D046988:Proteasome Endopeptidase Complex