title: Inhaled voriconazole for prevention of invasive pulmonary aspergillosis.
abstract: Targeted airway delivery of antifungals as prophylaxis against invasive aspergillosis may lead to high lung drug concentrations while avoiding toxicities associated with systemically administered agents. We evaluated the effectiveness of aerosolizing the intravenous formulation of voriconazole as prophylaxis against invasive pulmonary aspergillosis caused by Aspergillus fumigatus in an established murine model. Inhaled voriconazole significantly improved survival and limited the extent of invasive disease, as assessed by histopathology, compared to control and amphotericin B treatments.
authors.affiliation: The University of Texas at Austin College of Pharmacy, Austin, Texas, USA.
authors.forename: Justin A
authors.initials: JA
authors.lastname: Tolman
authors.forename: Nathan P
authors.initials: NP
authors.lastname: Wiederhold
authors.forename: Jason T
authors.initials: JT
authors.lastname: McConville
authors.forename: Laura K
authors.initials: LK
authors.lastname: Najvar
authors.forename: Rosie
authors.initials: R
authors.lastname: Bocanegra
authors.forename: Jay I
authors.initials: JI
authors.lastname: Peters
authors.forename: Jacqueline J
authors.initials: JJ
authors.lastname: Coalson
authors.forename: John R
authors.initials: JR
authors.lastname: Graybill
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Patterson
authors.forename: Robert O
authors.initials: RO
authors.lastname: Williams
mesh_terms: D000280:Administration, Inhalation; D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D055744:Invasive Pulmonary Aspergillosis / Q000517:prevention & control*; D051379:Mice; D008813:Mice, Inbred ICR; D011743:Pyrimidines / Q000008:administration & dosage*; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D000666:Amphotericin B; D065819:Voriconazole