title: Fiberoptic ductoscopy-guided intraductal biopsy improve the diagnosis of nipple discharge.
abstract: Fiberoptic ductoscopy (FDS)-guided intraductal biopsy is a minimally invasive technique developed to obtain pathologic diagnoses for patients with spontaneous nipple discharge. We performed biopsies of 53 intraductal lesions from March 2006 to April 2007 followed by surgical microdochectomy. FDS-guided intraductal biopsy was shown to be a minimally invasive, safe, and convenient technique with a high ability (90.6%) to get adequate samples. Twenty-seven solitary papillomas, 12 multiple intraductal papilloma, five ductal hyperplasia, three ductal carcinoma in situ, and one invasive ductal carcinoma were diagnosed. Compared with conventional microdochectomy, FDS-guided intraductal biopsy can significantly increase the detection rate of solitary papilloma (40.7% versus 92.6%, p < 0.05). It should be a routine procedure after intraductal lesion found by screening FDS. Since it would underestimate all multiple intraductal papilloma and some (50%) cancer, microdochectomy is inevitable if biopsies show atypical ductal hyperplasia.
authors.affiliation: Department of Surgery, Cancer Hospital, Fudan University, Shanghai, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ling
authors.forename: Guang-yu
authors.initials: GY
authors.lastname: Liu
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Lu
authors.forename: Susan
authors.initials: S
authors.lastname: Love
authors.forename: Jia-xin
authors.initials: JX
authors.lastname: Zhang
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Xu
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Xu
authors.forename: Kun-wei
authors.initials: KW
authors.lastname: Shen
authors.forename: Zhen-zhou
authors.initials: ZZ
authors.lastname: Shen
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Shao
mesh_terms: D001706:Biopsy / Q000379:methods; D001941:Breast Diseases / Q000473:pathology* / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000601:surgery; D005260:Female; D005336:Fiber Optic Technology / Q000295:instrumentation / Q000379:methods; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D009558:Nipples / Q000378:metabolism / Q000473:pathology*; D010212:Papilloma / Q000473:pathology / Q000601:surgery