Relic of ancient recombinations in gibbon ABO blood group genes deciphered through phylogenetic network analysis.
The primate ABO blood group gene encodes a glycosyl transferase (either A or B type), and is known to have large coalescence times among the allelic lineages in human. We determined nucleotide sequences of ca. 2.2kb of this gene for 23 individuals of three gibbon species (agile gibbon, white-handed gibbon, and siamang), and observed a total of 24 haplotypes. We found relics of five ancient intragenic recombinations, occurred during ca. 2-7 million years ago, through a phylogenetic network analysis. The coalescence time between A and B alleles estimate precede the divergence (ca. 8MYA) of siamang and common gibbon lineages. This establishes the coexistence of divergent allelic lineages of the ABO blood group gene for a long period in the ancestral gibbon species, and strengthens the non-neutral evolution for this gene.
Kitano
Takashi
T
Division of Population Genetics, National Institute of Genetics, Yata, Mishima, Japan.
Noda
Reiko
R
Takenaka
Osamu
O
Saitou
Naruya
N
D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D000818:Animals; D001483:Base Sequence; D019143:Evolution, Molecular; D006239:Haplotypes; D006922:Hylobates / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011995:Recombination, Genetic; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013045:Species Specificity
D000017:ABO Blood-Group System