title: Association of GNB3 C825T polymorphism with peak oxygen consumption.
abstract: The C825T single nucleotide polymorphism (SNP) in the guanine nucleotide-binding protein, beta polypeptide 3 ( GNB3) gene gives rise to a splice variant, GNB3s that has enhanced G protein activation and signal transduction activity. This variant has been reported to be associated with cardiovascular disease, diabetes and obesity. We studied this SNP in 95 healthy 18 to 30 year-old African American university students to determine its association with aerobic capacity and cardiorespiratory fitness as measured by peak oxygen consumption (VO (2)peak). We also tested the effect of heart rate variability (HRV) as an independent predictor of VO (2)peak. We tested the association of the SNP and HRV with VO (2)peak in a multivariate regression analysis with appropriate adjustments of covariates, under dominant and recessive models. We found a significant independent association of the 825T allele with VO (2)peak under the dominant model (beta-coef.=-0.101, P=0.0442). We also observed that HRV marginally influenced VO (2)peak. This finding suggests that GNB3 C825T polymorphism is associated with VO (2)peak which is influenced by autonomic modulation of heart rate in African Americans.
authors.affiliation: National Human Genome Center, Howard University, Washington, DC 20060, United States. mfaruque@howard.edu
authors.forename: M U
authors.initials: MU
authors.lastname: Faruque
authors.forename: R M
authors.initials: RM
authors.lastname: Millis
authors.forename: G M
authors.initials: GM
authors.lastname: Dunston
authors.forename: J
authors.initials: J
authors.lastname: Kwagyan
authors.forename: V
authors.initials: V
authors.lastname: Bond
authors.forename: C N
authors.initials: CN
authors.lastname: Rotimi
authors.forename: T
authors.initials: T
authors.lastname: Davis
authors.forename: R
authors.initials: R
authors.lastname: Christie
authors.forename: A L
authors.initials: AL
authors.lastname: Campbell
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics; D005260:Female; D006339:Heart Rate / Q000502:physiology; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D010101:Oxygen Consumption / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D015398:Signal Transduction / Q000235:genetics; D013334:Students; D014495:Universities; D055815:Young Adult
chemical_list: C454420:G-protein beta3 subunit; D020962:Heterotrimeric GTP-Binding Proteins