Comparison of various surgical methods in the treatment of implant-related infection.
The treatment of implant-related infections is troublesome. This study was conducted to compare the effectiveness of three different surgical modalities in the treatment of implant-related infection. A total of 32 Wistar albino rats were randomised into four groups after the establishment of implant-related infection: no treatment, surgical débridement, antibiotic-loaded bone cement and antibiotic-loaded autogenous bone. Microbiological colony counts were made at the sixth week in order to evaluate the effectiveness of of the treatments. The antibiotic-loaded bone cement group revealed superior results compared with the other groups in terms of reduction of microbiological colonies. Three animals in the bone cement group revealed extensive infection. Although antibiotic-loaded bone cement showed superiority over other treatment modalities, it should be employed after an unsuccessful trial of débridement because of the risk of extensive infection.
Sener
Muhittin
M
Department of Orthopaedics and Traumatology, Izmir Ataturk Training and Research Hospital, Izmir, Turkey. msener87@yahoo.com
Kazimoglu
Cemal
C
Karapinar
Hasan
H
Günal
Izge
I
Afşar
Ilhan
I
Karataş Sener
Asli Gamze
AG
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019643:Arthroplasty, Replacement; D001843:Bone Cements / Q000627:therapeutic use; D016025:Bone Transplantation; D003646:Debridement; D004195:Disease Models, Animal; D005260:Female; D020007:Implants, Experimental; D007595:Joint Prosthesis / Q000009:adverse effects / Q000382:microbiology; D019637:Orthopedic Procedures / Q000379:methods*; D010019:Osteomyelitis / Q000382:microbiology / Q000517:prevention & control / Q000601:surgery*; D016459:Prosthesis-Related Infections / Q000382:microbiology / Q000517:prevention & control / Q000601:surgery*; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control / Q000601:surgery; D013211:Staphylococcus aureus / Q000187:drug effects / Q000502:physiology; D013978:Tibial Fractures / Q000382:microbiology / Q000473:pathology / Q000601:surgery*
D000900:Anti-Bacterial Agents; D001843:Bone Cements