Correction of errors during protein synthesis.
Quality control: The incorporation of a wrong amino acid into a growing polypeptide chain induces a correction step in which the release factor (RF1) hydrolyzes the peptide from the incorrectly matched peptidyl-tRNA (see picture). The nascent erroneous polypeptide is released from the ribosome and degraded.
Sprinzl
Mathias
M
Laboratorium für Biochemie, Universität Bayreuth, Universitätstrasse 30, 95440 Bayreuth, Germany. mathias.sprinzl@uni-bayreuth.de
D000596:Amino Acids / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis / Q000235:genetics; D012270:Ribosomes / Q000378:metabolism
D000596:Amino Acids