Stress cardiomyopathy - a unique presentation of diabetic ketoacidosis.
We have documented a unique instance of diabetic ketoacidosis (DKA)-induced stress-related cardiomyopathy (CMP) in a 46-yr-old Caucasian female with type I diabetes mellitus. In times of stress, tissues with high capacity for aerobic metabolism, like myocardium, can preferentially change their metabolic substrate to ketones. The myocyte has a decreased ability to metabolize glucose and free fatty acids in stress CMP. To the best of our knowledge this is the first report of stress CMP complicating DKA. A possible mechanism for the same is hypothesized.
Nanda
Sudip
S
Department of Internal Medicine, St. Luke's Hospital, Bethlehem, PA, USA. sudipnanda2000@yahoo.com
Longo
Santo
S
Bhatt
Surya Prakash
SP
Pamula
John
J
Sharma
Shree Gopal
SG
Dale
Thompson H
TH
D009202:Cardiomyopathies / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000523:psychology; D016883:Diabetic Ketoacidosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D004452:Echocardiography; D005260:Female; D006801:Humans; D008875:Middle Aged; D013312:Stress, Physiological / Q000502:physiology*