title: [Multicenter follow-up report of 147 premature infants with brain injuries from 6 hospitals in China].
abstract: OBJECTIVE
  Sponsored by the Subspecialty Group of Neonatology of Pediatric Society, China Medical Association, more than 10 large-scale hospitals participated in the near two-year multicenter investigation for Brain Injuries in Premature Infants in China. The present study presents the follow-up results of 147 premature infants with brain injuries from 6 Third Class A Level hospitals.
  
  
  METHODS
  All premature infants with intraventricular hemorrhage (IVH) or periventricular leukomalacia (PVL) diagnosed in the early neonatal period in the 6 hospitals were followed-up between January 2005 and August 2006. Based on the synthetic results of physical development, examination of nervous system, intelligence tests and cranial ultrasound, the premature infants with brain injuries were classified as normal development, marginal development and retarded development.
  
  
  RESULTS
  One hundred and forty-seven premature infants with brain injuries from the 6 hospitals consisted of 141 cases of IVH and 36 cases of PVL (30 cases having IVH and PVL). Based on the synthetic follow-up results, 51.4% of premature infants with brain injuries were generally assessed as normal development, 38.4% as marginal development and 10.7% as retarded development. Among them, delayed growth in head circumference, height and weight was 13.4%; the occurrence frequency of cerebral paralysis (CP) was 7.1% in PVL grade I, 28.6% in PVL grade II and 100% in PVL grade III; 12.7% showed retarded development of intelligence; and 30% presented post-injurious changes on cranial sonography.
  
  
  CONCLUSIONS
  The data of the multicenter follow-up can basically reflect the short-term prognosis of premature infants with brain injuries in major big cities of China. About 10% of them have retarded physical, motor-and mental developments. The long-term regular follow-up study is expected for more premature infants with brain injuries, and behavioral sequelae of brain injuries which may occur in peri-school age and adolescence should be paid particularly close attention.
authors.affiliation: Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China. hjchenk@online.sh.cn
authors.forename: Hui-Jin
authors.initials: HJ
authors.lastname: Chen
authors.forename: Xiu-Fang
authors.initials: XF
authors.lastname: Fan
authors.forename: Xi-Rong
authors.initials: XR
authors.lastname: Gao
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Liu
authors.forename: Ben-Qing
authors.initials: BQ
authors.lastname: Wu
authors.forename: Gao-Qiang
authors.initials: GQ
authors.lastname: Wu
authors.forename: Cong-Le
authors.initials: CL
authors.lastname: Zhou
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications* / Q000503:physiopathology; D002547:Cerebral Palsy / Q000209:etiology; D004453:Echoencephalography; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007360:Intelligence; D007969:Leukomalacia, Periventricular / Q000150:complications* / Q000503:physiopathology