Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds.
The elaboration of a 6,6-spiroacetal scaffold to incorporate a nucleoside unit at the anomeric position is described. The novel spiroacetal-nucleoside hybrids were generated via nucleosidation of acetoxy-spiroacetal with a series of silylated nucleobases under Vorbrüggen conditions.
Choi
Ka Wai
KW
Department of Chemistry, The University of Auckland, 23 Symonds St, Auckland, New Zealand.
Brimble
Margaret A
MA
D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D001685:Biological Factors; D009705:Nucleosides; D013141:Spiro Compounds