title: Bladder outlet obstruction in painful bladder syndrome/interstitial cystitis.
abstract: OBJECTIVE
  Obstructive symptoms such as slow stream, dribbling and straining are often reported by painful bladder syndrome and interstitial cystitis (PBS/IC) patients. Our hypothesis was that some patients with PBS/IC have an associated measurable bladder outlet obstruction (BOO) secondary to dysfunctional voiding and that those patients with more severe PBS/IC are more likely to have BOO.
  
  
  METHODS
  This is a retrospective chart review of female patients diagnosed with PBS/IC based on the NIDDK research definition. Charts were reviewed for clinical symptom severity, ulcer or non-ulcer PBS/IC on cystoscopy, and pressure-flow urodynamics (UDPF). Patients were excluded if they had a urinary infection at the time of urodynamics or did not meet study entry requirements. The cut-off values of <or=12 ml/sec and >or=25 cm of water was used to define BOO.
  
  
  RESULTS
  Of the 231 women: 38 had ulcer PBS/IC and 193 had non-ulcer PBS/IC. MCC was 269 ml in non-ulcer PBS/IC and 200 ml in ulcer PBS/IC (P = 0.006). One hundred eleven women (48%) met criteria for obstruction. MCC was 298 ml in the non-obstructed group and 214 ml in the obstructed group (P < 0.0001). The maximum flow with non-ulcer PBS/IC was 11.0 ml/sec and in ulcer PBS/IC 8.9 ml/sec (P = 0.04) Detrusor pressure at maximum flow was 33.3 cm H(2)O, in non-ulcer, and 37.4 cm H(2)O in ulcer PBS/IC (P = 0.01).
  
  
  CONCLUSIONS
  Forty-eight percent of our PBS/IC patients have BOO, and increasing severity of PBS/IC is associated with higher voiding pressure.
authors.affiliation: Department of Urology, University of Michigan, Ann Arbor, Michigan, USA. annepell@med.umich.edu
authors.forename: Anne P
authors.initials: AP
authors.lastname: Cameron
authors.forename: Jerzy B
authors.initials: JB
authors.lastname: Gajewski
mesh_terms: D018856:Cystitis, Interstitial / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D001748:Urinary Bladder Neck Obstruction / Q000150:complications* / Q000453:epidemiology*