title: Recognition of non-self-polysaccharides by C-type lectin receptors dectin-1 and dectin-2.
abstract: The discovery of several transmembrane receptors expressed by antigen presenting cells, including those that detect and interact with specific sugar moieties on the surface of microbes, has improved our understanding of how immunity against infection is generated. This knowledge, in turn, prompted us to review such interactions with emphasis on C-type lectin receptors and a focus on the roles of dectin-1 and dectin-2 in anti-fungal immunity.
authors.affiliation: Department of Dermatology, University of Texas Southwestern Medical Center, Dallas Veterans Affairs Medical Center, Dallas, TX, USA.
authors.forename: S Tyler
authors.initials: ST
authors.lastname: Hollmig
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Ariizumi
authors.forename: Ponciano D
authors.initials: PD
authors.lastname: Cruz
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology*; D037222:Collectins / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D037181:Lectins, C-Type / Q000276:immunology*; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D009419:Nerve Tissue Proteins / Q000276:immunology*; D011134:Polysaccharides / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D000099181:Dectin-1
chemical_list: D015703:Antigens, CD; D037222:Collectins; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011134:Polysaccharides; D011956:Receptors, Cell Surface; D051192:Receptors, Pattern Recognition; D000099181:Dectin-1; C121916:CD207 protein, human; C445340:dectin-2, mouse