title: [Five years of kidney transplantation in Iaşi].
abstract: The activity of Renal Transplant Center Iaşi started in November 2000, when we realized the first renal transplant from a live donor. Since then, 46 renal transplants were successfully realized in our center, to patients aged between 13-47 years (medium age = 30 +/- 5), M/F=27/19, 25 (56.8%) of them selected from HD, 17 (39.9%) from CAPD and 4 (8.7%) pre-emptive. Medium age of donors was 49.1 years (30-64), M/F=29/17. The donors were, in 78.3% of cases, first-degree relatives (parents, siblings). In 10 cases (21.7%) the grafts were donated by "emotionally related"donors (in most cases, spouses). An urologist-cardiovascular surgeon team, performed the transplant operations. There were no important complications during operation. We had one major vascular complication (graft artery thrombosis) in a 13 years recipient, successfully resolved after thrombectomy and stenting. Immunosuppressive therapy associated induction with monoclonal antibodies anti-Tac, cyclosporine, MMF and prednisone. Eight patients from 46 (17.39%) presented acute rejection episodes and all responded at corticosteroids. Medium values of serum creatinine were: 1.54 mg% at 1 month, 1.42 mg% at 6 months, 1.44 mg% at 1 year, 1.21 mg% at 2 years, 1.38 mg% at 3 years, 1.4 mg% at 4 years and 1.2 at 5 years. The survival of patients and donors is 100% and the survival of renal graft--97.1% (one case of chronic allograft nephropathy with lost of renal function). We also present the satisfactory evolution of the 51 renal transplanted patients addressed to our center from different other renal transplantation centers in Romania for management follow-up.
authors.affiliation: Spitalul "C.I. Parhon" Iaşi, Clinica de Urologie.
authors.forename: C
authors.initials: C
authors.lastname: Novac
authors.forename: A
authors.initials: A
authors.lastname: Covic
authors.forename: Irina
authors.initials: I
authors.lastname: Buhăescu
authors.forename: G
authors.initials: G
authors.lastname: Tinică
authors.forename: Cireşica
authors.initials: C
authors.lastname: Diaconescu
authors.forename: V
authors.initials: V
authors.lastname: Diaconescu
authors.forename: P
authors.initials: P
authors.lastname: Gusbeth
authors.forename: Irina
authors.initials: I
authors.lastname: Negru
authors.forename: L
authors.initials: L
authors.lastname: Tudose
authors.forename: N
authors.initials: N
authors.lastname: Suditu
authors.forename: Veronica
authors.initials: V
authors.lastname: Tănase
authors.forename: B
authors.initials: B
authors.lastname: Alexandroaie
authors.forename: Maria
authors.initials: M
authors.lastname: Covic
mesh_terms: D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D012189:Retrospective Studies; D012383:Romania; D014019:Tissue Donors; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents