title: Altered DHEA and DHEAS response to exercise in healthy older adults.
abstract: Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are hormones produced by the adrenal cortex that decline in concentration with age. Decreased DHEA levels are associated with age-related disease and oxidative stress but might be increased in younger adults by exercise. Studies are presented assessing the response of DHEA and DHEAS to varied-intensity exercise in older age. DHEA increased significantly in young adults (14.5 +/- 6.1 ng/ml rising to 21.1 +/- 7.5 ng/ml; p < .01), whereas DHEAS decreased significantly (2.56 +/- 1.11 microg/ml falling to 1.90 +/- 0.8 microg/ml; p < .05), after submaximal exercise. DHEA and DHEAS levels were significantly lower in older adults than in younger adults (p < .01), and there was no observed response of either hormone to exercise in older adults. Lipoprotein protein carbonylation is presented as a measure of oxidative status and significantly decreased in younger adults postexercise. Participants with higher DHEA postexercise had lower LDL protein carbonyl concentrations (Pearson's coefficient -.409, p < .05).
authors.affiliation: School of Sport and Exercise Sciences, University of Birmingham, Edgbaston, UK.
authors.forename: Sarah
authors.initials: S
authors.lastname: Aldred
authors.forename: Manjit
authors.initials: M
authors.lastname: Rohalu
authors.forename: Kate
authors.initials: K
authors.lastname: Edwards
authors.forename: Victoria
authors.initials: V
authors.lastname: Burns
mesh_terms: D000367:Age Factors; D000368:Aged; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D019314:Dehydroepiandrosterone Sulfate / Q000378:metabolism*; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D018384:Oxidative Stress; D010101:Oxygen Consumption / Q000502:physiology; D055815:Young Adult
chemical_list: D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate