Various strategies for obtaining artificial hemoproteins: from "hemoabzymes" to "hemozymes".
The design of artificial hemoproteins that could lead to new biocatalysts for selective oxidation reactions of organic compounds presents a huge interest especially in pharmacology, both for a better understanding of the metabolic profile of drugs and for the synthesis of enantiomerically pure molecules that could be involved in the design of drugs. The present results show that the so-called "host-guest strategy" that involves the non-covalent incorporation of anionic water-soluble iron-porphyrins into xylanase A from Streptomyces lividans, a low cost protein, leads to such an artificial hemoprotein that is able to perform the stereoselective oxidation of sulfides.
Mahy
Jean-Pierre
JP
Institut de Chimie Moléculaire et des Matériaux d'Orsay, UMR 8182 CNRS, Laboratoire de Chimie Bioorganique et Bioinorganique, Bât. 420, Université Paris 11, 91405 Orsay Cedex, France. jpmahy@icmo.u-psud.fr
Raffy
Quentin
Q
Allard
Mathieu
M
Ricoux
Rémy
R
D006420:Hemeproteins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D008958:Models, Molecular; D010084:Oxidation-Reduction
D006420:Hemeproteins