title: Undernutrition and oxidative stress as risk factors for high blood pressure in older Mexican adults.
abstract: OBJECTIVE
  To determine the relationship between undernutrition and oxidative stress as risk factors for high blood pressure (HBP) in older Mexican adults. We carried out a case-control study in a convenience sample of 62 older adults, 60-80 years of age; 32 without HBP (mean age 75.8 +/- 5.1 years) and 30 with HBP (mean age 65.2 +/- 6.8 years).
  
  
  METHODS
  We measured serum lipoperoxide (LPO) levels, antioxidant enzymes, total antioxidant activity and lipid profile; in addition, we evaluated the nutritional status with anthropometric measurements, the Mini Nutritional Assessment and food intake frequency. Data were analyzed with Student t and odds ratio (OR) statistical tests.
  
  
  RESULTS
  We observed significantly higher LPO levels in subjects with HBP than in normotensive subjects (0.303 +/- 0.10 vs. 0.256 +/- 0.06 micromol/l; p < 0.05). With respect to risk factors for HBP, we found an OR of 12.2 (95% CI 1.9-76.4, p < 0.01) in subjects with high LPO levels (> or = 0.320 micromol/l) and an OR of 5.0 (95% CI 1.1-23.0, p < 0.05) in those with undernutrition.
  
  
  CONCLUSIONS
  Our findings suggest that high LPO levels and undernutrition are significant risk factors for HBP.
authors.affiliation: Unidad de Investigación en Gerontología, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México (UNAM), México, México. mendovic@servidor.unam.mx
authors.forename: Víctor Manuel
authors.initials: VM
authors.lastname: Mendoza-Núñez
authors.forename: Martha A
authors.initials: MA
authors.lastname: Sánchez-Rodríguez
authors.forename: Elsa
authors.initials: E
authors.lastname: Correa-Muñoz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000886:Anthropometry; D000975:Antioxidants / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D016022:Case-Control Studies; D005260:Female; D015577:Geriatric Assessment; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000453:epidemiology*; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008297:Male; D044342:Malnutrition / Q000097:blood*; D008800:Mexico; D008875:Middle Aged; D015596:Nutrition Assessment; D009752:Nutritional Status; D016017:Odds Ratio; D018384:Oxidative Stress; D012307:Risk Factors
chemical_list: D000975:Antioxidants; D008055:Lipids