title: Plasma 25,OH vitamin D concentrations are not associated with rheumatoid arthritis (RA)-related autoantibodies in individuals at elevated risk for RA.
abstract: OBJECTIVE
  To evaluate the association between rheumatoid arthritis (RA)-related autoantibodies and plasma 25,OH vitamin D in subjects at risk for RA.
  
  
  METHODS
  In 1210 subjects without RA, 76 were positive for anti-cyclic citrullinated peptide antibodies or for at least 2 rheumatoid factors (RF; by nephelometry: RF-IgM, RF-IgG, RF-IgA). 25,OH vitamin D was measured in these cases and 154 autoantibody-negative controls from this cohort.
  
  
  RESULTS
  25,OH vitamin D levels did not differ between cases and controls (adjusted OR 1.23, 95% CI 0.93-1.63).
  
  
  CONCLUSIONS
  Vitamin D concentrations are not associated with RA-related autoimmunity in unaffected subjects at increased risk for RA.
authors.affiliation: Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Denver, Colorado, USA.
authors.forename: Marie
authors.initials: M
authors.lastname: Feser
authors.forename: Lezlie A
authors.initials: LA
authors.lastname: Derber
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Deane
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Lezotte
authors.forename: Michael H
authors.initials: MH
authors.lastname: Weisman
authors.forename: Jane H
authors.initials: JH
authors.lastname: Buckner
authors.forename: Ted
authors.initials: T
authors.lastname: Mikuls
authors.forename: James
authors.initials: J
authors.lastname: O'Dell
authors.forename: Peter K
authors.initials: PK
authors.lastname: Gregersen
authors.forename: V Michael
authors.initials: VM
authors.lastname: Holers
authors.forename: Jill M
authors.initials: JM
authors.lastname: Norris
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D015415:Biomarkers; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology*; D012307:Risk Factors; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D007136:Immunoglobulins; D010456:Peptides, Cyclic; C487763:cyclic citrullinated peptide; D014807:Vitamin D; D012217:Rheumatoid Factor; C104450:25-hydroxyvitamin D