[Relationships between PON1 L55M polymorphism and coronary heart diseases complicated with fasting hyperglycemia in Han populations in Guangdong].
OBJECTIVE
To investigate the relationships between Paraoxonase1 (PON1) gene L55M polymorphism and coronary heart diseases (CHD) complicated with fasting hyperglycemia (FHG) or type 2 diabetes mellitus (T2DM).


METHODS
Two hundreds and eighty four patients were recruited in this study, which comprised 86 patients with CHD, 62 with CHD and FHG, 46 with CHD and T2DM, and 90 patients without the above conditions. The sequences of the PON1 gene L55M polymorphism were analysed by the SNPs methods.


RESULTS
The frequency of allele L was 0.86. No significant differences in the frequencies of the three genotypes (LL, LM, and MM) were found among the four groups of patients. The L allele of PON1 L55M was not associated with the number and range of coronary arterial lesions (chi2 = 0.56, P = 0.76; chi2 = 0.11, P = 0.74, respectively).


CONCLUSIONS
PON1 gene L55M polymorphism exists in Han populations in Guangdong, with LL as the main genotype. PON1 L55M gene polymorphism and allelic genes are not associated with the level of fasting blood glucose or diabetes mellitus. There is no evidence to support the relationship between PON1 L55M gene polymorphism and coronary artery lesions.
Zhou
Hong
H
Department of Endocrinology, West China Hospital, Sichuan University, Chengdu 610041, China.
Lu
Cheng-Zhi
CZ
Gao
Yun
Y
Long
Yang
Y
Tian
Hao-Ming
HM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D043303:Aryldialkylphosphatase / Q000235:genetics*; D001786:Blood Glucose; D002681:China; D003327:Coronary Disease / Q000150:complications* / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D001786:Blood Glucose; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human