Selective fetoscopic laser ablation in 100 consecutive pregnancies with severe twin-twin transfusion syndrome.
OBJECTIVE
To report the perinatal outcomes of a large series of twin pregnancies with severe twin-twin transfusion syndrome (TTTS) managed with laser ablation surgery in an Australian tertiary perinatal centre and to compare the outcome with other large cohorts.


METHODS
The outcomes of 100 consecutive pregnancies with severe TTTS managed with selective fetoscopic laser ablation from March 2002 to June 2007 were examined. Survival and neonatal morbidity were analysed. Comparisons were made with the results from other studies of laser surgery with at least 100 pregnancies.


RESULTS
There were 100 women with TTTS treated with laser ablation; 34 stage II, 44 stage III and 22 at stage IV. Median gestation at time of laser was 21 weeks (range 18-28) and median gestation at delivery was 31 weeks (range 20-39). Overall perinatal survival rate was 151 of 200 (75.5%). Eighty five per cent had one or more surviving twins. The survival rate for stage IV TTTS was 88.6%, significantly better than for stage II (69.1%) and stage III (73.9%) pregnancies. The perinatal mortality rate for donors (30%) was not significantly different from recipients (19%), but the fetal death rate for donors was significantly greater than that for recipients (P = 0.03). Severe cerebral abnormalities were present in only 2.8% of newborns. The overall survival rate was comparable to other large series.


CONCLUSIONS
These results for the management of severe TTTS are comparable to the best reported international series. Long-term follow-up is required and more research needs to be undertaken to further improve these results.
Cincotta
Robert B
RB
Department of Maternal Fetal Medicine, Mater Mothers' Hospital, South Brisbane, Queensland, Australia. rob@qufw.com.au
Gray
Peter H
PH
Gardener
Glenn
G
Soong
Barbara
B
Chan
Fung Yee
FY
D015331:Cohort Studies; D005260:Female; D046689:Fetal Mortality; D005330:Fetofetal Transfusion / Q000401:mortality / Q000601:surgery*; D005332:Fetoscopy; D006801:Humans; D007231:Infant, Newborn; D053685:Laser Therapy; D054238:Perinatal Mortality; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011793:Queensland / Q000453:epidemiology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis