Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women.
CYP1B1 is a key enzyme involved in estrogen metabolism and may play an important role in the development and progression of breast cancer. In a population-based case-control study, we examined eight CYP1B1 haplotype-tagging single nucleotide polymorphisms in relation to invasive breast cancer risk. Analyses were based on 1,655 cases and 1,470 controls; all women were Caucasian. Among the individual single nucleotide polymorphisms, one (rs9341266) was associated with increased risk of breast cancer (P(trend) = 0.021), although the association was no longer significant after adjusting for multiple tests. A marginally significant haplotype effect was identified (P(global) = 0.015), with significant associations identified for 2 uncommon haplotypes comprising 4% of the controls. Results suggest that genetic variation in CYP1B1 has at most a minor influence on breast cancer susceptibility among Caucasian women.
Huang
Yifan
Y
H. Lee Moffitt Cancer Center, Tampa, FL 33612, USA.
Trentham-Dietz
Amy
A
García-Closas
Montserrat
M
Newcomb
Polly A
PA
Titus-Ernstoff
Linda
L
Hampton
John M
JM
Chanock
Stephen J
SJ
Haines
Jonathan L
JL
Egan
Kathleen M
KM
D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D065633:Cytochrome P-450 CYP1B1; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D044465:White People / Q000235:genetics*; D055815:Young Adult
D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1