title: Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine.
abstract: Angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms are linked to endothelial dysfunction and to cerebral white matter lesions. Objectives of this study were to determine if ACE and MTHFR gene polymorphisms are associated with von Willebrand factor (vWF) activity, an endothelial dysfunction marker, and with a distinct headache phenotype. We enrolled 64 women (18-50 years old) with International Classification of Headache Disorders, 2nd edn migraine without aura (MoA) and 61 with aura (MA). Genotypic frequencies: ACE DD 35%, ID 42%, II 23%, and MTHFR TT 17%, CT 40%, CC 43%. Those with ACE DD genotype had higher levels of vWF activity (152%) compared with ID and II genotypes. Levels were highest (179%) with combined ACE DD and MTHFR TT genotypes. ACE DD was associated with higher headache frequency, and MTHFR TT was associated with MA. In migraine, vWF activity may be a marker of endothelial-mediated genetic risk for ischaemic conditions.
authors.affiliation: Department of Neurology, The University of Toledo College of Medicine, Toledo, OH 43614, USA. gretchen.tietjen@utoledo.edu
authors.forename: G E
authors.initials: GE
authors.lastname: Tietjen
authors.forename: N A
authors.initials: NA
authors.lastname: Herial
authors.forename: C
authors.initials: C
authors.lastname: Utley
authors.forename: L
authors.initials: L
authors.lastname: White
authors.forename: S
authors.initials: S
authors.lastname: Yerga-Woolwine
authors.forename: B
authors.initials: B
authors.lastname: Joe
mesh_terms: D000328:Adult; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D009154:Mutation; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012307:Risk Factors; D055815:Young Adult; D014841:von Willebrand Factor / Q000378:metabolism*
chemical_list: D014841:von Willebrand Factor; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D007703:Peptidyl-Dipeptidase A