title: T cell lymphoblastic lymphoma in parotidectomy for Warthin's tumor: case report and review of the literature.
abstract: Lymphomas associated with Warthin's tumor (WT) are extremely uncommon and the majorities are of B cell type. We report the simultaneous occurrence of T-cell lymphoblastic lymphoma (T-LBL) and WT in an 81-year-old patient, who presented with fever, night sweats and enlargement of the right parotid gland. The parotidectomy specimen showed a WT with extensive replacement of the lymphoid stroma by T-LBL, but preservation of the oncocytic epithelium. Staging investigations revealed mediastinal and abdominal lymphadenopathy, bilateral pleural effusions and bone marrow infiltration, in keeping with stage IVB disease. The patient received combination chemotherapy treatment but responded poorly, and died three months after diagnosis. To our knowledge, this is the first case report of T-LBL involving WT. The present study indicates that the lymphoid stroma in WT belongs to the systemic lymphoid tissue and can be involved in disseminated lymphoma. It highlights the importance of careful examination of WT's lymphoid stroma for the possible presence of any coexistent malignancy.
authors.affiliation: Department of Cellular Pathology, John Radcliffe Hospital, Oxford, UK.|Nuffield Department of Clinical Laboratory Sciences, John Radcliffe Hospital, Oxford, UK.
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Giaslakiotis
authors.affiliation: First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, GR-11527, Athens, Greece.
authors.forename: Athina
authors.initials: A
authors.lastname: Androulaki
authors.affiliation: First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.|Department of Hematology, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: George
authors.initials: G
authors.lastname: Panagoulias
authors.affiliation: First Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece.|Department of Hematology, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Maria-Christina
authors.initials: MC
authors.lastname: Kyrtsonis
authors.affiliation: First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, GR-11527, Athens, Greece.
authors.forename: Andreas C
authors.initials: AC
authors.lastname: Lazaris
authors.affiliation: First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, GR-11527, Athens, Greece. aristoteles_stageira@yahoo.com.
authors.forename: Dimitrios N
authors.initials: DN
authors.lastname: Kanakis
authors.affiliation: First Department of Pathology, School of Medicine, National and Kapodistrian University of Athens, 75 Mikras Asias Str., Goudi, GR-11527, Athens, Greece.
authors.forename: Efstratios S
authors.initials: ES
authors.lastname: Patsouris
mesh_terms: D000235:Adenolymphoma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*; D008297:Male; D016105:Parathyroidectomy; D010307:Parotid Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology* / Q000601:surgery*
chemical_list: D015703:Antigens, CD