An anatomical view on macrophages in tolerance.
Macrophages are divided into several functional subtypes involved in host defence, wound healing and immune regulation. In an alternate view, increased understanding of macrophage biology can also be gained by including anatomical location as a parameter. The focus of this review lies on tolerogenic features of macrophages relevant for autoimmune disease. The importance of macrophages as janitors clearing apoptotic cells and debris is seen in systemic lupus erythematosus (SLE) where a clearance defect often is connected to disease induction and progression. The apoptotic debris can be encountered by the macrophage in multiple anatomical compartments including the circulation but also in areas of intense cell death such as in the thymus and germinal center were tight regulation is important.
Wermeling
Fredrik
F
Department of Medicine, Karolinska Institutet, 171 76 Stockholm, Sweden.
Karlsson
Mikael C I
MC
McGaha
Tracy L
TL
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001327:Autoimmune Diseases / Q000473:pathology; D006801:Humans; D007108:Immune Tolerance; D008099:Liver / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D010587:Phagocytosis / Q000276:immunology; D011971:Receptors, Immunologic / Q000276:immunology; D013154:Spleen / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
C490460:MARCO protein, human; D011971:Receptors, Immunologic