The puzzle of RNAs that target gene promoters.
Setting the right target: Most researchers who use small RNAs in mammalian cells assume that mRNA will be the target. Recent studies suggest that small RNAs can also target chromosomal DNA. Few discoveries have had the impact of RNAi. Most researchers who use small RNAs to control gene expression in mammalian cells assume that mRNA will be the target. Recent studies, however, have suggested that small RNAs can also target chromosomal DNA.
Younger
Scott T
ST
Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390-9041, USA.
Corey
David R
DR
D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism; D005786:Gene Expression Regulation; D011401:Promoter Regions, Genetic; D016372:RNA, Antisense / Q000378:metabolism; D012330:RNA, Double-Stranded / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism*
D015852:Eukaryotic Initiation Factor-2; D016372:RNA, Antisense; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D022661:RNA, Untranslated