title: 2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation.
abstract: The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated.
authors.affiliation: Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.
authors.forename: Jimmy J
authors.initials: JJ
authors.lastname: Weterings
authors.forename: Selina
authors.initials: S
authors.lastname: Khan
authors.forename: Gerbrand J
authors.initials: GJ
authors.lastname: van der Heden van Noort
authors.forename: Cornelis J M
authors.initials: CJ
authors.lastname: Melief
authors.forename: Herman S
authors.initials: HS
authors.lastname: Overkleeft
authors.forename: Sjoerd H
authors.initials: SH
authors.lastname: van der Burg
authors.forename: Ferry
authors.initials: F
authors.lastname: Ossendorp
authors.forename: Gijsbert A
authors.initials: GA
authors.lastname: van der Marel
authors.forename: Dmitri V
authors.initials: DV
authors.lastname: Filippov
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000588:Amines / Q000737:chemistry; D000818:Animals; D001386:Azides / Q000737:chemistry; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D003713:Dendritic Cells / Q000166:cytology* / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D051199:Toll-Like Receptor 7 / Q000819:agonists* / Q000502:physiology
chemical_list: D000588:Amines; D001386:Azides; D051199:Toll-Like Receptor 7; C002992:8-hydroxyadenine; D000225:Adenine