title: Histiocytic erythema multiforme.
abstract: Erythema multiforme is histologically characterized by liquefactive degeneration along the dermal-epidermal junction, necrotic keratinocytes and a lymphocytic infiltrate. We report a 10-year-old boy with recurrent erythema multiforme major of undetermined etiology with unusual histologic findings. A skin biopsy taken at day 2 of his eruption revealed histologic features otherwise characteristic of erythema multiforme, but mediated instead by a CD68-positive infiltrate, resembling cutaneous Kikuchi's disease. To the best of our knowledge this is the first reported case of 'histiocytic' erythema multiforme.
authors.affiliation: Department of Pathology, Hahnemann University Hospital/Drexel College of Medicine, Philadelphia, PA, USA.
authors.forename: Anita
authors.initials: A
authors.lastname: Sebastian
authors.forename: Connor
authors.initials: C
authors.lastname: Patterson
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Zaenglein
authors.forename: Michael D
authors.initials: MD
authors.lastname: Ioffreda
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Helm
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002648:Child; D004892:Erythema Multiforme / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D016756:Immunoglobulins, Intravenous; C067980:CD68 antigen, human; D000097382:CD68 Molecule