Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
Azaindole based structures were evaluated as DP1 receptor antagonists. This work has lead to the discovery of potent, selective and distinct DP1 receptor antagonists.
Leblanc
Yves
Y
Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Quebec, Canada. yves_leblanc@merck.com
Roy
Patrick
P
Dufresne
Claude
C
Lachance
Nicolas
N
Wang
Zhaoyin
Z
O'Neill
Gary
G
Greig
Gillian
G
Denis
Danielle
D
Mathieu
Marie-Claude
MC
Slipetz
Deborah
D
Sawyer
Nicole
N
Tsou
Nancy
N
D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000502:physiology; D013329:Structure-Activity Relationship
D007211:Indoles; C518174:MK-0524; D011448:Prostaglandin Antagonists; D011982:Receptors, Prostaglandin; C501562:prostanoid D receptor 1, human