Human Th17 cells: are they different from murine Th17 cells?
Type 17 Th (Th17) cells have been identified as a distinct population of CD4(+) effector T cells different from Th1 and Th2 cells. While the pre-eminent cytokine of Th1 cells is IFN-gamma and that of Th2 cells is IL-4, the distinctive cytokine of Th17 cells is IL-17A. However, although murine and human Th1 and Th2 cells exhibit strong similarities, human and murine Th17 cells seem to differ in several aspects.
Annunziato
Francesco
F
Center of Excellence for Research, Transfer of Research and High Education for the Development of Novel therapies, University of Florence, Florence, Italy.
Cosmi
Lorenzo
L
Liotta
Francesco
F
Maggi
Enrico
E
Romagnani
Sergio
S
D000818:Animals; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology* / Q000378:metabolism; D037181:Lectins, C-Type / Q000276:immunology / Q000378:metabolism; D051379:Mice; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000276:immunology / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000276:immunology / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism; D018417:Th1 Cells / Q000276:immunology* / Q000378:metabolism; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
C400041:CLEC2D protein, human; D020381:Interleukin-17; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011956:Receptors, Cell Surface