title: The effects of spinal anesthesia on cerebral blood flow in the very elderly.
abstract: BACKGROUND
  Aging and disease may make elderly patients particularly susceptible to hypotension during spinal anesthesia. However, the impact of small-dose bupivacaine on cerebral hemodynamics is not known. In this study, we assessed the effects of spinal anesthesia on cerebral blood flow (CBF) in very elderly patients.
  
  
  METHODS
  We prospectively studied 20 patients aged >75 yr who underwent open surgical repair of a hip fracture and compared them with a control group of patients younger than 60 yr. Patients were placed in the lateral decubitus position to receive spinal anesthesia at L4-5 level. Noninvasive automated arterial blood pressure, heart rate, and transcranial Doppler measurements were recorded before spinal anesthesia (baseline = T0), 5 min after the end of local anesthetic injection (T1), 10 min after spinal anesthesia (T2), and in the postanesthesia care unit (T3).
  
  
  RESULTS
  Systolic blood pressure significantly decreased at T1 (115 +/- 25 mm Hg) and T2 (114 +/- 24 mm Hg) compared with T0 (136 +/- 21 mm Hg) in the elderly group. Systolic and diastolic velocities significantly decreased compared to baseline values (at T1, T2). Significant modifications of the pulsatility index (PI) and resistance index occurred at T2 for PI and resistance index. No patient experienced an episode of bradycardia. Heart rate variations were not significantly different compared to T0. Neither hemodynamics nor cerebral effects were observed in the control group.
  
  
  CONCLUSIONS
  In summary, spinal anesthesia results in a very small but statistically significant reduction of CBF velocity in very elderly patients.
authors.affiliation: Department of Anesthesiology and Intensive Care, GRCB 48, University Hospital of Toulouse, University Paul Sabatier, Toulouse, France. vincentminville@yahoo.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Minville
authors.forename: Karim
authors.initials: K
authors.lastname: Asehnoune
authors.forename: Sabrina
authors.initials: S
authors.lastname: Salau
authors.forename: Benoît
authors.initials: B
authors.lastname: Bourdet
authors.forename: Bernard
authors.initials: B
authors.lastname: Tissot
authors.forename: Vincent
authors.initials: V
authors.lastname: Lubrano
authors.forename: Olivier
authors.initials: O
authors.lastname: Fourcade
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000775:Anesthesia, Spinal; D000779:Anesthetics, Local / Q000008:administration & dosage*; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000008:administration & dosage*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006620:Hip Fractures / Q000601:surgery; D006801:Humans; D007022:Hypotension / Q000503:physiopathology; D017078:Laser-Doppler Flowmetry; D008159:Lumbar Vertebrae; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000187:drug effects* / Q000503:physiopathology; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000187:drug effects; D017585:Ultrasonography, Doppler, Transcranial; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000779:Anesthetics, Local; D002045:Bupivacaine