title: Afferent islands are larger than mu-opioid receptor patch in striatum of rat pups.
abstract: Dopamine afferent islands were observed in rodent caudate-putamen only during development, whereas patches with intense mu-opioid receptor (MOR) immunoreactivity were seen throughout the life. We performed direct comparison between MOR patches and dopamine islands in the caudate-putamen of rat pups, by double immunofluorescence labeling for MOR and tyrosine hydroxylase. MOR patches were included in dopamine islands at postnatal day (P) 0 to P8, although the patches occupied the same region as the islands at P12-16. Furthermore, the regions of glutamatergic afferents with intense vesicular glutamate transporter 1 and vesicular glutamate transporter 2 immunoreactivities well corresponded to those of dopamine islands at P4. These results suggest that the striatal 'afferent islands' are larger than MOR patches in the early postnatal life.
authors.affiliation: Department of Morphological Brain Science, Graduate School of Medicine, Kyoto University, Sakyo-ku, Kyoto, Japan. nakamura@mbs.med.kyoto-u.ac.jp
authors.forename: Kouichi C
authors.initials: KC
authors.lastname: Nakamura
authors.forename: Fumino
authors.initials: F
authors.lastname: Fujiyama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Furuta
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hioki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kaneko
mesh_terms: D000818:Animals; D002421:Caudate Nucleus / Q000254:growth & development / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D009474:Neurons / Q000378:metabolism*; D011699:Putamen / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017450:Receptors, Opioid, mu / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism; D050599:Vesicular Glutamate Transport Protein 2 / Q000378:metabolism
chemical_list: D017450:Receptors, Opioid, mu; D050599:Vesicular Glutamate Transport Protein 2; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine