[Synthesis and physico-chemical characterisation of some new derivatives of rutoside and clofibric acid].
Fibrates are drugs with efficacy in reducing blood cholesterol levels and especially, triglyceride plasma levels. Unfortunately, fibrates have a poor water-solubility and showed some adverse reactions at long treatment. The objective of this study was to obtain some new clofibric acid derivatives with rutin; some of these compounds contain a guanidine moiety, known as effective at cardiovascular level. All the compounds are soluble in water.
Lupaşcu
D
D
Universitatea de Medicină şi Farmacie "Gr.T. Popa" Iaşi, Facultatea de Farmacie, Disciplina de Chimie farmaceutică.
Profire
Lenuţa
L
Dănilă
Gh
G
D002318:Cardiovascular Diseases / Q000188:drug therapy; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D000960:Hypolipidemic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D012431:Rutin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry*; D012995:Solubility; D014867:Water
D000960:Hypolipidemic Agents; D014867:Water; D002995:Clofibric Acid; D012431:Rutin