Biochemical signaling pathways for memory T cell recall.
Memory T cells exhibit low activation thresholds and rapid effector responses following antigen stimulation, contrasting naive T cells with high activation thresholds and no effector responses. Signaling mechanisms for the distinct properties of naive and memory T cells remain poorly understood. Here, I will discuss new results on signal transduction in naive and memory T cells that suggest proximal control of activation threshold and a distinct biochemical pathway to rapid recall. The signaling and transcriptional pathways controlling immediate effector function in memory T cells closely resemble pathways for rapid effector cytokine production in innate immune cells, suggesting memory T cells use innate pathways for efficacious responses.
Farber
Donna L
DL
Department of Surgery, University of Maryland School of Medicine, MSTF Building, Room 400, 685 W. Baltimore Street, Baltimore, MD 21201, United States. dfarber@smail.umaryland.edu
D000818:Animals; D018106:CD28 Antigens / Q000276:immunology / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007156:Immunologic Memory; D051966:Phospholipase C gamma / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D020825:T-Box Domain Proteins / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism*; D015533:Transcriptional Activation / Q000276:immunology; D051746:ZAP-70 Protein-Tyrosine Kinase / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism; D000098815:T-bet Transcription Factor
D018106:CD28 Antigens; D016207:Cytokines; D011948:Receptors, Antigen, T-Cell; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D051746:ZAP-70 Protein-Tyrosine Kinase; D048051:p38 Mitogen-Activated Protein Kinases; D051966:Phospholipase C gamma