Vitamin D receptor genotypes and kidney allograft rejection.
OBJECTIVE
Transplantation of renal grafts is an established treatment for renal failure in a variety of medical conditions. Polymorphisms in genes, coding for proteins involved in immune response, may influence immunological and non-immunological mechanisms that lead to allograft loss. Vitamin D receptor (VDR) agonist has been shown to reduce short and long term allograft rejection in animal model. There are functional polymorphisms in VDR gene.


METHODS
A total of 75 renal allograft recipients with at least 2 years follow-up were selected and genotyped for two polymorphisms in the VDR genes (FokI and BsmI) and the association of each genotype with renal allograft survival and acute rejection was evaluated.


RESULTS
We are unable to find statistically significant association between any of the study polymorphisms and clinical outcomes.


CONCLUSIONS
We have found no evidence to suggest that either VDR FokI or BsmI polymorphism determines the incidence of acute rejection or graft survival after renal transplantation. A larger sample size is necessary to confirm these findings.
Azarpira
Negar
N
Organ Transplant Research Center, Nemazi Hospital, Shiraz University of Medical Sciences, Zand Street, 7193711351 Shiraz, Iran. negarazarpira@yahoo.com
Sagheb
Mohamad M
MM
Geramizadeh
Bita
B
Darai
Masumeh
M
D000208:Acute Disease; D000328:Adult; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D018167:Receptors, Calcitriol / Q000235:genetics*; D014184:Transplantation, Homologous
D018167:Receptors, Calcitriol