Antifungal activities of natural and synthetic iron chelators alone and in combination with azole and polyene antibiotics against Aspergillus fumigatus.
Antifungal effects of iron chelators (lactoferrin, deferoxamine, deferiprone, and ciclopirox) were tested alone and in combination with antifungal drugs against Aspergillus fumigatus B5233 conidia. Lactoferrin, ciclopirox, and deferiprone inhibited whereas deferoxamine enhanced fungal growth. Antifungal synergy against conidia was observed for combinations of ketoconazole with ciclopirox or deferiprone, lactoferrin with amphotericin B, and fluconazole with deferiprone. Iron chelation alone or combined with antifungal drugs may be useful for prevention and treatment of mycosis.
Zarember
Kol A
KA
Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1456, USA. kzarember@niaid.nih.gov
Cruz
Anna R
AR
Huang
Chiung-Yu
CY
Gallin
John I
JI
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects*; D000077768:Ciclopirox; D000077543:Deferiprone; D004338:Drug Combinations; D015725:Fluconazole / Q000494:pharmacology; D007502:Iron Chelating Agents / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011728:Pyridones / Q000494:pharmacology
D000935:Antifungal Agents; D004338:Drug Combinations; D007502:Iron Chelating Agents; D011728:Pyridones; D000077768:Ciclopirox; D000077543:Deferiprone; D000666:Amphotericin B; D015725:Fluconazole; D007654:Ketoconazole