title: Relationships between the structures of flavanone derivatives and their effects in enhancing early growth response-1 gene expression.
abstract: To identify the structural requirements that are pivotal in enhancing Early growth response-1 (Egr-1) expression, the quantitative relationships between the structural properties of flavanone derivatives and their increments of Egr-1 expression were elucidated using comparative molecular field analysis and comparative molecular similarity indices analysis.
authors.affiliation: Division of Bioscience and Biotechnology, BMIC, RCD, Konkuk University, Seoul, Republic of Korea.
authors.forename: Sunhee
authors.initials: S
authors.lastname: Lee
authors.forename: Yoonkyung
authors.initials: Y
authors.lastname: Woo
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Shin
authors.forename: Young Han
authors.initials: YH
authors.lastname: Lee
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
mesh_terms: D051766:Early Growth Response Protein 1 / Q000096:biosynthesis* / Q000235:genetics*; D044950:Flavanones / Q000737:chemistry* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D006367:HeLa Cells; D006801:Humans; D021281:Quantitative Structure-Activity Relationship
chemical_list: D051766:Early Growth Response Protein 1; D044950:Flavanones