title: Inhibition of LPS-induced pulmonary inflammation by specific flavonoids.
abstract: In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute pulmonary inflammation. The flavonoid fisetin significantly reduced lung myeloperoxidase-levels and gene-expression of inflammatory mediators such as IL-6, TNF-alpha, IL-1beta, MIP-1alpha and MIP-2. The LPS-induced gene transcription of HO-1 and SOD2 was also significantly reduced by fisetin. Overall, the anti-inflammatory effects of fisetin in this in vivo model were much more pronounced as compared to the observed effects of flavone or tricetin and the anti-inflammatory glucocorticoid dexamethasone. The results of this study indicate that flavonoids such as fisetin might be potential candidates as pharmaceuticals or nutraceuticals in the treatment of pulmonary inflammatory diseases.
authors.affiliation: Department of Pharmacology and Toxicology, Maastricht University Maastricht, The Netherlands. liesbeth.geraets@rivm.nl
authors.forename: Liesbeth
authors.initials: L
authors.lastname: Geraets
authors.forename: Astrid
authors.initials: A
authors.lastname: Haegens
authors.forename: Karen
authors.initials: K
authors.lastname: Brauers
authors.forename: Jane A
authors.initials: JA
authors.lastname: Haydock
authors.forename: Juanita H J
authors.initials: JH
authors.lastname: Vernooy
authors.forename: Emiel F M
authors.initials: EF
authors.lastname: Wouters
authors.forename: Aalt
authors.initials: A
authors.lastname: Bast
authors.forename: Geja J
authors.initials: GJ
authors.lastname: Hageman
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002867:Chromones / Q000627:therapeutic use*; D047309:Flavones; D005419:Flavonoids / Q000627:therapeutic use*; D044948:Flavonols; D015870:Gene Expression; D051547:Heme Oxygenase-1 / Q000235:genetics; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D020556:Neutrophil Infiltration; D009195:Peroxidase / Q000037:antagonists & inhibitors; D011014:Pneumonia / Q000188:drug therapy* / Q000276:immunology; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D013482:Superoxide Dismutase / Q000235:genetics; D000099156:Superoxide Dismutase 2
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D047309:Flavones; D005419:Flavonoids; D044948:Flavonols; D051547:Heme Oxygenase-1; D018836:Inflammation Mediators; D015850:Interleukin-6; D008070:Lipopolysaccharides; D009195:Peroxidase; D000071137:Poly (ADP-Ribose) Polymerase-1; D011065:Poly(ADP-ribose) Polymerases; D013482:Superoxide Dismutase; D000099156:Superoxide Dismutase 2; C469689:tricetin; C499321:Parp1 protein, mouse; C017875:fisetin; C043562:flavone