title: Obesity is not a risk factor in children with reflux esophagitis: a retrospective analysis of 738 children.
abstract: Obesity has been associated with various gastrointestinal diseases in children, but the role of obesity in gastroesophageal reflux disease (GERD) has not been clearly established. The aim of the study was to investigate whether obesity and/or being overweight are risk factors for reflux esophagitis in children. A retrospective analysis of endoscopy charts was reviewed. Demographic, weight, height, and histology results were obtained from each patient. The body mass index (BMI) and BMI Z-score were calculated according to known formula. The diagnosis of GERD was established by histology. The charts of 738 children were reviewed; of these, 345 (47%) children were overweight or obese. Histological findings compatible with GERD were found in 254 (65%) children with normal weight, 111 (69%) overweight children, and 126 (68%) obese children (P > 0.05). Among those reviewed, the mean age of children with normal weight was significantly younger than that of overweight or obese children (P = 0.0001). A single variant analysis showed a significant association between GERD and male gender (P = 0.0001). Multivariant analysis (gender, age, and BMI Z-score) showed that GERD was significantly associated with male gender (P < 0.0001), but not with age (P = 0.443) or BMI Z-score (P = 0.098). In symptomatic children with histologically proven GERD, only male gender was an independent risk factor for GERD, not obesity or being overweight. Large, prospective studies in children that capture a larger spectrum of GERD are clearly warranted.
authors.affiliation: Department of Pediatrics, Section of Gastroenterology, Joan C. Edwards School of Medicine, Marshall University, Huntington, West Virginia 25701, USA. elitsur@marshall.edu
authors.forename: Yoram
authors.initials: Y
authors.lastname: Elitsur
authors.forename: Yulia
authors.initials: Y
authors.lastname: Dementieva
authors.forename: Rotem
authors.initials: R
authors.lastname: Elitsur
authors.forename: Mary
authors.initials: M
authors.lastname: Rewalt
mesh_terms: D000293:Adolescent; D000367:Age Factors; D015992:Body Mass Index; D002648:Child; D005260:Female; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000473:pathology; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D009765:Obesity / Q000150:complications* / Q000473:pathology; D050177:Overweight / Q000150:complications / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D012727:Sex Characteristics