Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy.
Depression is frequently reported in epilepsy patients; however, mechanisms of co-morbidity between epilepsy and depression are poorly understood. An important mechanism of depression is disinhibition within the hypothalamo-pituitary-adrenocortical (HPA) axis. We examined the functional state of the HPA axis in a rat model of co-morbidity between temporal lobe epilepsy and depression. Epilepsy was accompanied by the interictal elevation of plasma corticosterone, and by the positively combined dexamethasone/corticotropin releasing hormone test. The extent of the HPA hyperactivity was independent of recurrent seizures, but positively correlated with the severity of depressive behavior. We suggest that the observed hyperactivity of the HPA axis may underlie co-morbidity between epilepsy and depression.
Mazarati
Andrey M
AM
Department of Pediatrics, Neurology Division, David Geffen School of Medicine, University of California Los Angeles, BOX 951752, 22-474 MDCC, Los Angeles, CA 90095-1752, USA. mazarati@ucla.edu
Shin
Don
D
Kwon
Young Se
YS
Bragin
Anatol
A
Pineda
Eduardo
E
Tio
Delia
D
Taylor
Anna N
AN
Sankar
Raman
R
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003345:Corticosterone / Q000097:blood*; D003863:Depression / Q000097:blood* / Q000150:complications* / Q000503:physiopathology; D004195:Disease Models, Animal; D004567:Electrodes, Implanted; D004833:Epilepsy, Temporal Lobe / Q000097:blood* / Q000139:chemically induced / Q000150:complications*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D018021:Lithium Chloride; D008297:Male; D008839:Microelectrodes; D010862:Pilocarpine; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011569:Psychiatric Status Rating Scales; D011863:Radioimmunoassay; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000097:blood / Q000150:complications / Q000503:physiopathology; D013315:Stress, Psychological / Q000503:physiopathology / Q000523:psychology
D010862:Pilocarpine; D018021:Lithium Chloride; D003345:Corticosterone