title: Dietary administration of high doses of pterostilbene and quercetin to mice is not toxic.
abstract: The aim of this study is to evaluate possible harmful effects of high doses of t-pterostilbene (t-PTER) and quercetin (QUER) in Swiss mice. Mice were fed during 28 days at doses of 0, 30, 300, and 3000 mg/kg body weight/day of t-PTER, QUER, or a mixture of both, t-PTER + QUER, which are equivalent to 5, 50, and 500 times, respectively, the estimated mean human intake of these polyphenols (25 mg/day). Daily oral administration of QUER, t-PTER, or a mixture of both of them did not cause mortality during the experimental period. There were no differences in food and water consumption on sex. No significant body weight gain in the male or female groups was observed. Red blood cell number and the hematocrit increased after polyphenols administration compared to control groups. Biochemical parameters were not affected. Histopathological examination revealed no alterations in clinical signs or organ weight at any dose.
authors.affiliation: Departamento de Fisiología, Facultat de Farmàcia, Universitat de València, Valencia, Spain. M.Jose.Ruiz@uv.es
authors.forename: M J
authors.initials: MJ
authors.lastname: Ruiz
authors.forename: M
authors.initials: M
authors.lastname: Fernández
authors.forename: Y
authors.initials: Y
authors.lastname: Picó
authors.forename: J
authors.initials: J
authors.lastname: Mañes
authors.forename: M
authors.initials: M
authors.lastname: Asensi
authors.forename: C
authors.initials: C
authors.lastname: Carda
authors.forename: G
authors.initials: G
authors.lastname: Asensio
authors.forename: J M
authors.initials: JM
authors.lastname: Estrela
mesh_terms: D000818:Animals; D004032:Diet; D004906:Erythrocyte Count; D005260:Female; D006400:Hematocrit; D008297:Male; D051379:Mice; D011794:Quercetin / Q000008:administration & dosage / Q000633:toxicity*; D012727:Sex Characteristics; D013267:Stilbenes / Q000008:administration & dosage / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D013267:Stilbenes; C107773:pterostilbene; D011794:Quercetin