Tumors that look for their springtime in APRIL.
Inflammatory cells produce a proliferation inducing ligand (APRIL), one of the most recently cloned members of the tumor necrosis factor (TNF) family. Early experiments implicated APRIL as a promoting factor in the natural course of various cancers, reinforcing the concept that host inflammatory reactions are part of a tumor development. Recent studies have further analyzed the tumor-promoting role of APRIL in patients with solid tumors or with hematological malignancies. Here, we will review the recent literature, and provide evidence that APRIL may be a useful prognostic tool and a potential target in the treatment of some cancers.
Roosnek
E
E
Division of Hematology, Geneva University Hospitals, Switzerland.
Burjanadze
M
M
Dietrich
P Y
PY
Matthes
T
T
Passweg
J
J
Huard
B
B
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000502:physiology*
D053300:Tumor Necrosis Factor Ligand Superfamily Member 13