Anti-beta(2)-glycoprotein-I and anti-phosphatidylserine antibodies in women with spontaneous pregnancy loss.
OBJECTIVE
To evaluate the role of anti-beta(2)-glycoprotein-I (anti-beta(2)GPI-ab) and anti-phosphatidylserine (aPS-ab) antibodies as a risk factor in both recurrent miscarriage (RM) and unexplained fetal losses (UFL).


METHODS
Retrospective, cohort study.


METHODS
Vall d'Hebron University Hospital, Barcelona, Spain.


METHODS
122 pregnant women divided in two groups: study group of 54 women with RM and/or UFL and control group of 68 pregnant without RM history.


METHODS
Analysis of lupus anticoagulant, anticardiolipin antibodies, and anti-beta(2)GP1 and aPS antibodies.


METHODS
Comparison of aPL antibody between groups.


RESULTS
The prevalence of aPL positive results was 8 out of 54 (14.8%) in the study group and 3 out of 68 (4.41%) in the controls. In the RM subgroup, the prevalence was 3 out of 25 (12%) versus 3 out of 68 (4.4%), and 7 out of 34 (20.6%) versus 3 out of 68 (4.4%) in UFL subgroup. As a whole, the prevalence of anti-beta(2)GP1-ab in the RM/UFL group showed a difference compared with controls but not aPS-ab. In the RM women, anti-beta(2)GP1-ab was positive in 3 out of 25 (12%) versus 1 out of 68 (1.5%) in controls and in 4 out of 34 versus 0 out of 68 cases in women with UFL. In the RM subgroup, aPS-ab was positive in 1 out of 25 (4%) versus 2 out of 68 (2.9%) in control group and in 3 out of 34 versus 2 out of 68 cases in women with UFL.


CONCLUSIONS
Our results suggest that anti-beta(2)GP1-ab but not aPS-ab is related to RM/UFL and should be considered as a pregnancy-loss risk factor.
Alijotas-Reig
Jaume
J
Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d'Hebron University Hospital, Barcelona, Spain. 16297jar@comb.es
Ferrer-Oliveras
Raquel
R
Rodrigo-Anoro
Maria José
MJ
Farran-Codina
Immaculada
I
Cabero-Roura
Luis
L
Vilardell-Tarres
Miquel
M
D000022:Abortion, Spontaneous / Q000097:blood* / Q000209:etiology / Q000276:immunology; D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000502:physiology; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications / Q000453:epidemiology; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008875:Middle Aged; D010718:Phosphatidylserines / Q000276:immunology*; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D055815:Young Adult; D053482:beta 2-Glycoprotein I / Q000276:immunology*
D001323:Autoantibodies; D010718:Phosphatidylserines; D053482:beta 2-Glycoprotein I