title: [Irritable bowel syndrome: dietary and pharmacological therapeutic options].
abstract: In irritable bowel syndrome, the main objectives of the treatment are the relief of abdominal pain then the improvement of bowel disturbances. Spasmolytic agents, or clays remain routinely the first line pharmacological options. The efficacy of dietary recommendations is not validated in most of the cases while dietary fibers, mainly insoluble fibers, may even worsen abdominal discomfort. In C-IBS, osmotic laxatives or macrogol are effective to improve colonic transit while loperamide and also colestyramine can be prescribed to reduce the number of stools of D-IBS patients. When the first line treatment fails to improve symptoms, antidepressants (tricyclic rather than SSRs) can be prescribed at lower doses than that recommended for depression. In meta-analysis, the odds ratio for pain relief varies from 2 to 4 and strongly depends on the patient's compliance to the treatment. Probiotics, pregabalin and even antibiotics (i.e neomycin, metronidazole or rifaximin), are possible new therapeutic options. Few clinical trials suggest that ramosetron (a new 5HT3 antagonist), octreotide, melatonin, or lidocain could be also discussed in the future. A non pharmacological therapeutic approach has to be considered, particularly in patients with severe symptoms, in combination with pharmacological treatment.
authors.affiliation: ADEN EA 4311/IFRMP 23, Département d'Hépato-Gastroentérologie et de Nutrition, CHRU, Hôpital Charles Nicolle, 1, rue de Germont, 76031 Rouen cedex, France. philippe.ducrotte@chu-rouen.fr
authors.forename: P
authors.initials: P
authors.lastname: Ducrotté
mesh_terms: D015746:Abdominal Pain / Q000628:therapy; D000700:Analgesics / Q000627:therapeutic use; D000779:Anesthetics, Local / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D002492:Central Nervous System Depressants / Q000627:therapeutic use; D004032:Diet; D004043:Dietary Fiber / Q000008:administration & dosage; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000628:therapy*; D008012:Lidocaine / Q000627:therapeutic use; D008550:Melatonin / Q000627:therapeutic use; D015282:Octreotide / Q000627:therapeutic use; D010276:Parasympatholytics / Q000627:therapeutic use; D000069583:Pregabalin; D019936:Probiotics / Q000627:therapeutic use; D012702:Serotonin Antagonists / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D000900:Anti-Bacterial Agents; D000928:Antidepressive Agents; D002492:Central Nervous System Depressants; D004043:Dietary Fiber; D005765:Gastrointestinal Agents; D010276:Parasympatholytics; D012702:Serotonin Antagonists; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D008012:Lidocaine; D008550:Melatonin; D015282:Octreotide