title: Adult orbital langerhans cell histiocytosis with frontal bone involvement.
abstract: A 28-year-old woman presented with a 2-week history of right upper eyelid swelling and intermittent frontal headaches. CT demonstrated an ill-defined superior right orbital mass with adjacent right frontal bone erosion and undeveloped frontal sinuses. The orbital biopsy revealed tissue strongly positive for CD1a and S100, diagnostic of Langerhans cell histiocytosis. The systemic workup was negative for multifocal lesions and for diabetes insipidus. In addition to subtotal resection, the patient was treated with a 6-month course of oral prednisone and intravenous vinblastine.
authors.affiliation: Department of Ophthalmology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, USA. jsokolmd@gmail.com
authors.forename: Jason A
authors.initials: JA
authors.lastname: Sokol
authors.forename: Michael
authors.initials: M
authors.lastname: Kazim
authors.forename: Kara M
authors.initials: KM
authors.lastname: Kelly
authors.forename: George
authors.initials: G
authors.lastname: Lantos
authors.forename: Loh-Shan
authors.initials: LS
authors.lastname: Leung
authors.forename: Edward
authors.initials: E
authors.lastname: Baron
mesh_terms: D000284:Administration, Oral; D000328:Adult; D018949:Antigens, CD1 / Q000032:analysis; D003919:Diabetes Insipidus / Q000517:prevention & control; D005260:Female; D005624:Frontal Bone / Q000000981:diagnostic imaging; D005938:Glucocorticoids / Q000008:administration & dosage; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007275:Injections, Intravenous; D008279:Magnetic Resonance Imaging; D009915:Orbit / Q000276:immunology / Q000473:pathology; D009916:Orbital Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D011241:Prednisone / Q000008:administration & dosage; D009418:S100 Proteins / Q000032:analysis; D014057:Tomography, X-Ray Computed; D014747:Vinblastine / Q000008:administration & dosage
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D005938:Glucocorticoids; D009418:S100 Proteins; D014747:Vinblastine; D011241:Prednisone