title: Discovery of potent and selective DP1 receptor antagonists in the azaindole series.
abstract: Azaindole based structures were evaluated as DP1 receptor antagonists. This work has lead to the discovery of potent, selective and distinct DP1 receptor antagonists.
authors.affiliation: Merck Frosst Centre for Therapeutic Research, Pointe Claire-Dorval, Quebec, Canada. yves_leblanc@merck.com
authors.forename: Yves
authors.initials: Y
authors.lastname: Leblanc
authors.forename: Patrick
authors.initials: P
authors.lastname: Roy
authors.forename: Claude
authors.initials: C
authors.lastname: Dufresne
authors.forename: Nicolas
authors.initials: N
authors.lastname: Lachance
authors.forename: Zhaoyin
authors.initials: Z
authors.lastname: Wang
authors.forename: Gary
authors.initials: G
authors.lastname: O'Neill
authors.forename: Gillian
authors.initials: G
authors.lastname: Greig
authors.forename: Danielle
authors.initials: D
authors.lastname: Denis
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Mathieu
authors.forename: Deborah
authors.initials: D
authors.lastname: Slipetz
authors.forename: Nicole
authors.initials: N
authors.lastname: Sawyer
authors.forename: Nancy
authors.initials: N
authors.lastname: Tsou
mesh_terms: D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011448:Prostaglandin Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors* / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; C518174:MK-0524; D011448:Prostaglandin Antagonists; D011982:Receptors, Prostaglandin; C501562:prostanoid D receptor 1, human