title: Correlation of NT-proBNP with metabolic liver function as assessed with (13)C-methacetin breath test in patients with acute decompensated heart failure.
abstract: Metabolic liver function is significantly decreased in patients with advanced chronic heart failure (CHF). The purpose of the study was to evaluate correlation of NT-proBNP with metabolic liver function as assessed with (13)C-methacetin breath test in patients with acute decompensation of chronic heart failure (ADHF). NT-proBNP, (13)C-methacetin breath test and investigation of other biochemical parameters were realized on days 0-2 (V1) and 2-7 (V2) after hospital admission in 13 consecutive ADHF patients. NT-proBNP and metabolic liver function as assessed with (13)C-methacetin breath test didn't change in the first days after hospital admission in ADHF patients. Correlation of NT-proBNP with the degree of metabolic liver function impairement was not significant. The study revealed significant correlation of NT-proBNP with serum ceruloplasmin and significant inverse correlation of liver function with total iron binding capacity in patients with ADHF. The results of this pilot study should be confirmed in a study with larger patient population.
authors.forename: Miluše
authors.initials: M
authors.lastname: Hendrichová
authors.forename: Filip
authors.initials: F
authors.lastname: Málek
authors.forename: Helena
authors.initials: H
authors.lastname: Kopřivová
authors.forename: Jana
authors.initials: J
authors.lastname: Vránová
authors.forename: Petr
authors.initials: P
authors.lastname: Ošťádal
authors.forename: Karolína
authors.initials: K
authors.lastname: Krátká
authors.forename: Miluše
authors.initials: M
authors.lastname: Sedláková
authors.forename: Jiří
authors.initials: J
authors.lastname: Horák
mesh_terms: D000081:Acetamides / Q000032:analysis*; D001944:Breath Tests; D002247:Carbon Isotopes / Q000032:analysis; D006333:Heart Failure / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D000081:Acetamides; D002247:Carbon Isotopes; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; C035495:methacetin