Family history of affective illness in schizophrenia patients: symptoms and cognition.
This study examined the relationship between having a family history of affective disorder and neuropsychological functioning and PANSS symptoms in schizophrenia patients falling into four exclusive family history groups (affective spectrum disorders, schizophrenia spectrum disorders, both, or neither). Schizophrenia patients with a family history of affective illness had the best performance on IQ tests and executive function measures. Symptoms showed fewer family history group differences. Schizophrenia patients with a family history of affective disorder may be a distinct subtype in the group of schizophrenias and may be biologically more similar to patients with serious affective disorder.
Anglin
Deidre
D
Department of Psychology, The City College and The Graduate Center, City University of New York, United States. dma2105@columbia.edu
Stanford
Arielle D
AD
Harkavy-Friedman
Jill M
JM
Goetz
Raymond
R
Rosenfield
Paul
P
Malaspina
Dolores
D
D000328:Adult; D003072:Cognition Disorders / Q000209:etiology*; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000209:etiology*; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D055815:Young Adult