Acute otitis media due to Haemophilus influenzae with antibiotic resistance: experience of a tertiary hospital in Tokyo city.
OBJECTIVE
The objective of the study was to clarify the associated factors of pediatric acute otitis media (AOM) due to Haemophilus influenzae with antibiotic resistance.


METHODS
A retrospective chart review was conducted for all AOM cases due to H.influenzae in children younger than 2 years of age that were presented at the Department of Otolaryngology, Japanese Red Cross Medical Hospital (JRCMC), Tokyo, from April 2005 to March 2007.


RESULTS
Seventy-six children were enrolled in this study. Multivariate analysis showed that residing at the JRCMC infant home (OR, 3.7; [95% CI, 1.1-12.8]; P=0.039) and a history of consuming macrolide in the past month (OR, 4.7; [95% CI, 1.1-21.5]; P=0.041) were the associated factors for AOM due to beta-lactamase positive, ampicillin-resistant H. influenzae.


CONCLUSIONS
A history of consuming macrolide in the past month should be noted on antibiotic prescriptions for children with AOM who are younger than 2 years of age.
Tanaka
K
K
Department of Otolaryngology, Japanese Red Cross Medical Center, Hiroo 4-1-22, Shibuya-ku, Tokyo 150-8935, Japan. ktan-tky@umin.ac.jp
Ichikawa
T
T
Yano
J
J
D000208:Acute Disease; D000668:Ampicillin Resistance; D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D006193:Haemophilus influenzae / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007251:Influenza, Human / Q000150:complications*; D008297:Male; D010033:Otitis Media / Q000382:microbiology*; D012189:Retrospective Studies; D018440:beta-Lactam Resistance