[Effect of a traditional Chinese medicine compound on chronic heart failure in guinea-pigs].
OBJECTIVE
To investigate the effect of a traditional Chinese medicine compound (CTMC) on chronic heart failure (CHF) in guinea-pigs.


METHODS
The CHF of guinea-pigs were induced by repeated injection of hyodemic isoproterenol. The hemodynamics, organ (heart, lung, liver and kidney)/body weight ratio, pathological changes, and serum cTn-I and CK-MB were measured to determine the effectiveness of the traditional Chinese medicine treatement.


RESULTS
The LVDP and LVEDP were decreased and the absolute value of + dp/dt(max) and - dp/ dt(max) were increased by the administration of 10 mg/kg, 20 mg/kg and 30 mg/kg of the compound tablets. The effect increased with doses. The traditional Chinese medicine also decreased the area of myocardial necrosis and the degree of injury to myocardiacyte. The intervention group had lower serum cTn-I and CK-MB levels than the controls.


CONCLUSIONS
The compound tablets can improve the left ventricular diastolic function of CHF and reduce the myocardial damage in a dose-dependent manner.
Tan
Wu-Hong
WH
Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education, Key Laboratory of Trace Elements and Endemic Disease of Ministry of Health, Xi'an Jiaotong University, Xi'an 710061, China.
Du
Xiao-Yang
XY
Liu
Jian
J
Zhai
Lian-Bang
LB
Wang
Li-Xin
LX
Geng
Dong
D
D000818:Animals; D002316:Cardiotonic Agents / Q000627:therapeutic use; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D006333:Heart Failure / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008517:Phytotherapy; D011897:Random Allocation; D016277:Ventricular Function, Left / Q000187:drug effects*
D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal