title: Thinking outside the F-box: novel ligands for novel receptors.
abstract: The importance of regulated proteolysis in the physiology and development of plants is highlighted by the large number of genes dedicated to proteasome-dependent protein degradation. Within the SCF class of E3 ubiquitin ligases are more than 700 F-box proteins that act as recognition modules to specifically target their dedicated substrates for ubiquitylation. This review focuses on very recent studies indicating that some F-box proteins function as phytohormone or light receptors, which directly perceive signals and facilitate specific target-protein degradation to regulate downstream pathways. If this new connection between ligand-regulated proteolysis and signaling proves to be more extensive, an entirely new way of understanding the control of signal transduction is in the offing.
authors.affiliation: Department of Plant Cellular and Molecular Biology, The Ohio State University, 054 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA. somers.24@osu.edu
authors.forename: David E
authors.initials: DE
authors.lastname: Somers
authors.forename: Sumire
authors.initials: S
authors.lastname: Fujiwara
mesh_terms: D044783:F-Box Proteins / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D010937:Plant Growth Regulators / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011485:Protein Binding / Q000528:radiation effects; D011956:Receptors, Cell Surface / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D054875:Ubiquitination / Q000528:radiation effects
chemical_list: D044783:F-Box Proteins; D008024:Ligands; D010937:Plant Growth Regulators; D010940:Plant Proteins; D011956:Receptors, Cell Surface; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex