title: Gastric malignancies in breast cancer survivors: pathology and outcomes.
abstract: BACKGROUND
  As the number of breast cancer survivors increases, the appearance of second malignancies and unusual metastatic patterns likely also is increasing. In particular, we and others have observed gastric malignancies in breast cancer survivors.
  
  
  METHODS
  We reviewed 3 regional hospital system tumor databases, comprising 19,049 analytic breast cancer cases, to determine the number, types, and outcomes of subsequent gastric malignancies.
  
  
  RESULTS
  Twenty-eight patients developed subsequent gastric malignancies, representing .15% of breast cancer survivors; 82% of patients had gastric symptoms. Overall survival for the cohort was 39%. Twenty-four patients (86%) had gastric primaries and 13 died of their second cancers. Four patients had gastric metastases; all had lobular histology in both their primary tumors and metastatic lesions. Five patients had gastrointestinal stromal tumors; all patients underwent resection and currently are alive.
  
  
  CONCLUSIONS
  Gastric symptoms in breast cancer survivors may represent malignant lesions, often second primaries. All gastric metastases in our series were of lobular histology.
authors.affiliation: Department of Surgery, Division of Surgical Oncology, Oregon Health & Science University, Portland, OR 97239, USA.
authors.forename: Michelle C
authors.initials: MC
authors.lastname: Ellis
authors.forename: Teresa
authors.initials: T
authors.lastname: Mason
authors.forename: Jim
authors.initials: J
authors.lastname: Barnett
authors.forename: Leah L
authors.initials: LL
authors.lastname: Kiesow
authors.forename: John T
authors.initials: JT
authors.lastname: Vetto
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000453:epidemiology; D006801:Humans; D008223:Lymphoma / Q000453:epidemiology; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000453:epidemiology*; D012042:Registries; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000556:secondary