title: Characterization of brain development in the ferret via MRI.
abstract: Animal models with complex cortical development are useful for improving our understanding of the wide spectrum of neurodevelopmental challenges facing human preterm infants. MRI techniques can define both cerebral injury and alterations in cerebral development with translation between animal models and the human infant. We hypothesized that the immature ferret would display a similar sequence of brain development [both gray (GM) and white matter (WM)] to that of the preterm human infant. We describe postnatal ferret neurodevelopment with conventional and diffusion MRI. The ferret is born lissencephalic with a thin cortical plate and relatively large ventricles. Cortical folding and WM maturation take place during the first month of life. From the mid-second through the third week of postnatal life, the ferret brain undergoes a similar, though less complex, pattern of maturational changes to those observed in the human brain during the second half of gestation. GM anisotropy decreases rapidly in the first 3 wks of life, followed by an upward surge of surface folding and WM anisotropy over the next 2 wks.
authors.affiliation: Department of Pediatrics, Mallinckrodt Institute of Radiology, Washington University, 660 South Euclid Avenue, St. Louis, MO 63110, USA.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Barnette
authors.forename: Jeffery J
authors.initials: JJ
authors.lastname: Neil
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Kroenke
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Griffith
authors.forename: Adrian A
authors.initials: AA
authors.lastname: Epstein
authors.forename: Philip V
authors.initials: PV
authors.lastname: Bayly
authors.forename: Andrew K
authors.initials: AK
authors.lastname: Knutsen
authors.forename: Terrie E
authors.initials: TE
authors.lastname: Inder
mesh_terms: D000818:Animals; D016880:Anisotropy; D001921:Brain / Q000254:growth & development*; D005289:Ferrets / Q000254:growth & development*; D008279:Magnetic Resonance Imaging / Q000379:methods