Role of fibrinolysis in obesity and thrombosis.
Obesity is a common disorder and a known risk factor for thrombotic complications. Development of obesity is associated with extensive modifications in adipose tissue involving adipogenesis, angiogenesis and extracellular matrix proteolysis. The fibrinolytic (plasminogen/plasmin) system plays an important role in these processes. Studies using a nutritionally induced obesity model in transgenic mice support a role of the fibrinolytic system in adipogenesis and obesity. Studies using venous or arterial thrombosis models in obese mice, with impaired fibrinolytic activity, confirm a prothrombotic risk associated with obesity.
Lijnen
H R
HR
Center for Molecular and Vascular Biology, KU Leuven, Belgium. roger.lijnen@med.kuleuven.be
D050156:Adipogenesis; D000273:Adipose Tissue / Q000254:growth & development / Q000378:metabolism; D000818:Animals; D004195:Disease Models, Animal; D005342:Fibrinolysis; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D012307:Risk Factors; D013927:Thrombosis / Q000097:blood / Q000209:etiology*
D017395:Plasminogen Activator Inhibitor 1