title: Fluorescence navigation with indocyanine green for detecting sentinel nodes in extramammary Paget's disease and squamous cell carcinoma.
abstract: The radioisotope navigation method, which has usually been used for identification of sentinel nodes, is less useful in locating sentinel nodes close to primary lesions in cases of extramammary Paget's disease because of overlapping radioactivity from the primary site. We applied fluorescence navigation with indocyanine green (ICG) in two patients with skin cancer to cover this defect. The use of a charge-coupled device camera enabled real-time visualization of dynamic lymph flow without skin incision. The inguinal skin over the identified sentinel node with a handheld gamma probe was in accordance with the point detected by ICG fluorescence in a patient with squamous cell carcinoma of the foot. Sentinel node biopsy using fluorescence navigation with ICG proved to be easy and reliable.
authors.affiliation: Department of Dermatology, Shimane University School of Medicine, Izumo, Shimane, Japan. ytsujino@med.shimane-u.ac.jp
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tsujino
authors.forename: Kazuo
authors.initials: K
authors.lastname: Mizumoto
authors.forename: Yuki
authors.initials: Y
authors.lastname: Matsuzaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Niihara
authors.forename: Eishin
authors.initials: E
authors.lastname: Morita
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D004396:Coloring Agents; D005453:Fluorescence; D005528:Foot; D005837:Genitalia, Male; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D010145:Paget Disease, Extramammary / Q000473:pathology*; D021701:Sentinel Lymph Node Biopsy / Q000379:methods*; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green