[Comparative experimental study of the effect of various locally administered pharmacological agents on the appearance of peritoneal adhesions].
The paper evaluates the intensity of peritoneal adhesions induced by talc administration on Wistar rats, alone and in association with different other substances. The comparative study was performed on 40 rats, separated in 5 groups: group A was injected intraperitoneally with talc, group B with talc and streptokinase, group C with talc and heparin, group D with talc and dexamethasone and group E with talc and dextran. The adherence syndrome was evaluated after 3 weeks, scoring 5 parameters: number, density, strength, vascularization, topography and granulomas. The sum of these 5 parameters was defined as the adherence score. The best results in preventing adhesion formation are obtained with the intraperitoneal administration of dextran and streptokinase.
Perju
D
D
Spitalul Judeţean de Urgenţe Bacău.
Lupaşcu
Cr
C
D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage*; D051520:Antiperspirants / Q000009:adverse effects; D003907:Dexamethasone / Q000008:administration & dosage; D003911:Dextrans / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D005938:Glucocorticoids / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D010532:Peritoneal Diseases / Q000139:chemically induced; D051381:Rats; D017208:Rats, Wistar; D013300:Streptokinase / Q000008:administration & dosage*; D013627:Talc / Q000008:administration & dosage / Q000009:adverse effects; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
D000925:Anticoagulants; D051520:Antiperspirants; D003911:Dextrans; D005343:Fibrinolytic Agents; D005938:Glucocorticoids; D013627:Talc; D003907:Dexamethasone; D006493:Heparin; D013300:Streptokinase