title: Fatal ongoing human cytomegalovirus reactivation during high-dose melphalan and autologous stem cell transplantation.
abstract: Human cytomegalovirus (HCMV) reactivation can cause a wide range of complications in hematopoietic stem cell transplant recipients, ranging from pneumonia to graft failure. Although reactivations are usually seen in the early post-transplant period, ongoing and untreated HCMV reactivation at the time of high-dose chemotherapy and autologous stem cell support is an exceedingly rare circumstance whose consequences remain largely unknown. This case report describes a patient who underwent high-dose melphalan and autologous transplantation with unknown active HCMV replication.
authors.affiliation: Division of Hematology, Department of Oncology, Transplants and Advances in Medicine, University of Pisa, Pisa, Italy. dfocosi@tin.it
authors.forename: Daniele
authors.initials: D
authors.lastname: Focosi
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Sordi
authors.forename: Federico
authors.initials: F
authors.lastname: Papineschi
authors.forename: Edoardo
authors.initials: E
authors.lastname: Benedetti
authors.forename: Sara
authors.initials: S
authors.lastname: Galimberti
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini