title: Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors.
abstract: Aminopeptidase N (APN) is a zinc-dependent ectopeptidase which plays an important role in the invasion of metastatic tumors. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent inhibitory activities toward APN with IC50 values in the micromolar range.
authors.affiliation: State Key Laboratory of Food Science and Technology, Nanchang University, PR China.
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Huang
authors.forename: Fang
authors.initials: F
authors.lastname: Xiong
authors.forename: Xi
authors.initials: X
authors.lastname: Mai
authors.forename: Bin-Hai
authors.initials: BH
authors.lastname: Kuang
authors.forename: Cheng-Mei
authors.initials: CM
authors.lastname: Liu
authors.forename: Guo-Gang
authors.initials: GG
authors.lastname: Tu