title: Semipreparative HPLC enantioseparation, chiroptical properties, and absolute configuration of two novel cyclooxygenase-2 inhibitors.
abstract: A direct semipreparative HPLC enantioseparation of two chiral thiazolidinone derivatives having cyclooxygenase-2 inhibition activity was performed on the Chiralpak IA chiral stationary phase. Semipreparative amounts of enantiopure forms were collected using acetonitrile-ethanol-trifluoroacetic acid mixtures as mobile phase. The absolute configuration of both compounds was unequivocally established by single-crystal X-ray diffraction method and correlated to the chiroptical properties of isolated enantiomers.
authors.affiliation: Istituto Superiore di Sanità, Dipartimento del Farmaco, Rome, Italy. rcirilli@iss.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Cirilli
authors.forename: Stefano
authors.initials: S
authors.lastname: Fiore
authors.forename: Francesco
authors.initials: F
authors.lastname: La Torre
authors.forename: Elias
authors.initials: E
authors.lastname: Maccioni
authors.forename: Daniela
authors.initials: D
authors.lastname: Secci
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Sanna
authors.forename: Cristina
authors.initials: C
authors.lastname: Faggi