Antihepatotoxic activity and chemical constituents of Buddleja asiatica Lour.
A new natural compound, named 6-O-(3",4"-dimethoxycinnamoyl) catalpol, was isolated from the defatted alcoholic extract of the flowering parts of Buddleja asiatica Lour. (family Scrophulariaceae). Other separated known compounds included steroids (beta-sitosterol, stigmasterol, stigmasterol-O-glucoside, beta-sitosterol-O-glucoside), iridoid glucosides (methyl catalpol, catalpol, aucubin), phenylpropanoids (isoacteoside and acteoside), a triterpene saponin (mimengoside A), flavonoids (diosmin and linarin) in addition to the free sugars mannitol and sucrose. The structures of the isolated compounds were established by 1H and 13C NMR and mass spectrometry. Furthermore, the polar fraction of the flowering parts and the roots showed substantial antihepatotoxic activity comparable to that of the lignan silymarin.
El-Domiaty
Maher M
MM
Department of Pharmacognosy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Wink
Michael
M
Abdel Aal
Mahmoud M
MM
Abou-Hashem
Maged M
MM
Abd-Alla
Rehab H
RH