title: Impact of accelerator-based boron neutron capture therapy (AB-BNCT) on the treatment of multiple liver tumors and malignant pleural mesothelioma.
abstract: OBJECTIVE
  To confirm the feasibility of accelerator-based BNCT (AB-BNCT) for treatment of multiple liver tumors and malignant pleural mesothelioma (MPM), we compared dose distribution and irradiation time between AB-BNCT and reactor-based BNCT (RB-BNCT).
  
  
  METHODS
  We constructed treatment plans for AB-BNCT and RB-BNCT of four multiple liver tumors and six MPM. The neutron beam data on RB-BNCT were those from the research reactor at Kyoto University Research Reactor Institute (KURRI). The irradiation time and dose-volume histogram data were assessed for each BNCT system.
  
  
  RESULTS
  In BNCT for multiple liver tumors, when the 5 Gy-Eq dose was delivered as the mean dose to the healthy liver tissues, the mean dose delivered to the liver tumors by AB-BNCT and RB-BNCT was 68.1 and 65.1 Gy-Eq, respectively. In BNCT for MPM, when the mean lung dose to the normal ipsilateral lung was 5 Gy-Eq, the mean dose delivered to the MPM tumor by AB-BNCT and RB-BNCT was 20.2 and 19.9 Gy-Eq, respectively. Dose distribution analysis revealed that AB-BNCT is superior to RB-BNCT for treatment of deep-seated tumors.
  
  
  CONCLUSIONS
  The feasibility of the AB-BNCT system constructed at our institute was confirmed from a clinical viewpoint in BNCT for multiple liver tumors and MPM.
authors.affiliation: Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Osaka, Japan. msuzuki@rri.kyoto-u.ac.jp
authors.forename: Minoru
authors.initials: M
authors.lastname: Suzuki
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Sakurai
authors.forename: Genro
authors.initials: G
authors.lastname: Kashino
authors.forename: Liu
authors.initials: L
authors.lastname: Yong
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Masunaga
authors.forename: Yuko
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authors.lastname: Kinashi
authors.forename: Toshinori
authors.initials: T
authors.lastname: Mitsumoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Yajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tsutsui
authors.forename: Takemi
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authors.lastname: Sato
authors.forename: Akira
authors.initials: A
authors.lastname: Maruhashi
authors.forename: Koji
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authors.lastname: Ono