title: Reactions of conjugate phosphinyl- and phosphonyl-nitroso alkenes with enamines. Preparation of N-hydroxypyrrole derivatives.
abstract: The synthesis of highly functionalized N-hydroxypyrrole derivatives by the formal [3+2] cycloaddition reaction of enamines and nitroso alkenes derived from phosphine oxides and phosphonates is reported. Intermediate phosphorylated nitrones, whose formation can be explained by a conjugate addition of enamines to phosphorylated nitroso alkenes and formation of the five-membered heterocycles, are isolated.
authors.affiliation: Departamento de Quimica Organica I, Facultad de Farmacia, Universidad del Pais Vasco, Apartado 450, 01080 Vitoria, Spain.
authors.forename: Jesús M
authors.initials: JM
authors.lastname: de los Santos
authors.forename: Roberto
authors.initials: R
authors.lastname: Ignacio
authors.forename: Domitila
authors.initials: D
authors.lastname: Aparicio
authors.forename: Francisco
authors.initials: F
authors.lastname: Palacios
authors.forename: José M
authors.initials: JM
authors.lastname: Ezpeleta