A microfluidic high-resolution NMR flow probe.
A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.
Bart
Jacob
J
Mesa+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands.
Kolkman
Ard J
AJ
Oosthoek-de Vries
Anna Jo
AJ
Koch
Kaspar
K
Nieuwland
Pieter J
PJ
Janssen
Hans J W G
HJ
van Bentum
Jan P J M
JP
Ampt
Kirsten A M
KA
Rutjes
Floris P J T
FP
Wijmenga
Sybren S
SS
Gardeniers
Han J G E
HJ
Kentgens
Arno P M
AP