Binding reactions: epigenetic switches, signal transduction and cancer.
Simple binding interactions lie at the heart of disparate biological functions. Multiple negative and positive 'add-ons', often with small individual effects, make elementary systems that work, work better. Cancer illustrates various of these fundamental processes gone awry.
Ptashne
Mark
M
Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 595, New York, NY 10021, USA. m-ptashne@mskcc.org