Spontaneous autoinflation of saline mammary implants: further studies.
BACKGROUND
Previous studies have reported a hyperinflation of saline-filled breast implants. On removal, the implant fluid had changed from clear saline to a yellowish-brown color, with a viscous consistency similar to serum.


OBJECTIVE
Our objective was to identify further the components of saline from implants that had undergone spontaneous autoinflation. Our hypothesis was that if serum albumin is present in the fluid, then other proteins would likely be found.


METHODS
To screen and identify proteins in implant fluid, we used a proteomics-based approach that included 1- and 2-dimensional gel electrophoresis and mass spectrometry of protein samples.


RESULTS
Four known proteins and 1 unknown protein product were identified. Based on 2-dimensional gel electrophoresis and mass spectrometry, 2 general observations can be made about the saline from the autoinflated implants: serum albumin was the most prevalent protein, and there are a large number of proteins that remain to be identified.


CONCLUSIONS
There are multiple macromolecules that cross into the lumen of the prosthesis. We believe spontaneous autoinflation is occurring more often than is believed or reported.
Robinson
O Gordon
OG
Benos
Dale J
DJ
Mazzochi
Christopher
C