title: Endoscopic resection of advanced anterior skull base lesions: oncologically safe?
abstract: OBJECTIVE
  (1) Learn if margins of resection in advanced anterior skull base tumors that are resected via endoscopic-assisted means are comparable with traditional craniofacial resection (CFR). (2) Understand the difference in patient morbidity with endoscopic surgery compared to traditional CFR.
  
  
  METHODS
  Retrospective review of 41 patients undergoing surgery for comparably staged advanced malignancies of the anterior skull base between 2000 and 2006. Eighteen patients underwent endoscopic surgery and 23 patients underwent traditional CFR for American Joint Committee on Cancer stage III, IV or Kadish stage C lesions of the paranasal sinuses and anterior skull base. Margins were evaluated and follow-up ranged from 3 months to 5 years.
  
  
  RESULTS
  Of the 18 patients undergoing endoscopic resections, margins were positive/close in 17% (3/18). Margins were positive/close in 17% (4/23) of patients undergoing CFR. Five complications were seen in 4/18 patients (22%) undergoing endoscopic surgery and 11 postoperative complications were seen in 7/23 patients (30%) undergoing CFR. Mean duration of hospitalization was 5.22 and 7.17 days for the endoscopic and CFR groups, respectively.
  
  
  CONCLUSIONS
  There does not appear to be increased risk of positive margins in patients with advanced lesions undergoing endoscopic-assisted resection. Furthermore, the incidence of morbidity and duration of stay may be improved with endoscopic techniques.
authors.affiliation: Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA.
authors.forename: Marc A
authors.initials: MA
authors.lastname: Cohen
authors.forename: Jonathan
authors.initials: J
authors.lastname: Liang
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Cohen
authors.forename: M Sean
authors.initials: MS
authors.lastname: Grady
authors.forename: Bert W
authors.initials: BW
authors.lastname: O'Malley
authors.forename: Jason G
authors.initials: JG
authors.lastname: Newman