title: Total synthesis of (-)-bitungolide F.
abstract: An efficient total synthesis of (-)-bitungolide F (6) in 17 steps and 20.1% yield is described herein. Key steps involve a Myers asymmetric alkylation to introduce the C6 methyl with proper stereochemistry, a Claisen-like cyclization to construct the alpha,beta-unsaturated delta-lactone and a Julia-Kocienski olefination to assemble the conjugated diene moiety.
authors.affiliation: Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Yingpeng
authors.initials: Y
authors.lastname: Su
authors.forename: Yanfen
authors.initials: Y
authors.lastname: Xu
authors.forename: Junjie
authors.initials: J
authors.lastname: Han
authors.forename: Jiyue
authors.initials: J
authors.lastname: Zheng
authors.forename: Jing
authors.initials: J
authors.lastname: Qi
authors.forename: Tuo
authors.initials: T
authors.lastname: Jiang
authors.forename: Xinfu
authors.initials: X
authors.lastname: Pan
authors.forename: Xuegong
authors.initials: X
authors.lastname: She