Cardiovascular regeneration: pushing and pulling on progenitors.
In this issue of Cell Stem Cell, Zaruba et al. (2009) describe a pharmacoregenerative strategy for myocardial infarction. Using G-CSF to release progenitors from bone marrow and protease inhibition to prevent degradation of the homing signal, SDF-1, the authors achieve increased recruitment to the heart and improved heart function.
Steinhauser
Matthew L
ML
Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115-6110, USA.
Lee
Richard T
RT