Association between immunohistochemical markers of myocardial damage and apoptosis.
Cardiac disease is the most common cause of sudden unexpected death. In forensic practice there is a need for more sensitive diagnostic methods for the post-mortem diagnosis of myocardial damage. The aim of this study was to evaluate the association of the markers routinely used for the diagnosis of acute cardiac necrosis (myosin, troponin I and myoglobin with) and the presence of apoptosis, in order to evaluate the utility of apoptosis for use as a diagnostic marker during the early stage of acute myocardial damage. A positive correlation was observed between neovascularization and signs of recent and past necrosis. Not relationship was observed between age at death, post-mortem interval and apoptosis. No statistical association was found between the expression of acute cardiac necrosis markers and the presence of apoptosis.
Casalod
Y
Y
Department of Forensic Medicine, Faculty of Medicine, University of Zaragoza, C/Domingo Miral, S/N, 50009 Zaragoza, Spain. ycasalod@unizar.es
Alegret
R
R
Martinez-Jarreta
B
B
Gomez Zapata
M
M
Luna
A
A