title: Nucleophilic addition onto methyl-4H-1,4-oxazine-3-carboxylate moiety: short access to 1,4-diazine privileged substructures.
abstract: To determine the synthetic potential of the original 1,4-oxazine ring, which appears as a valuable building block for the synthesis of more complex derivatives, Michael-type nucleophilic additions were studied. According to the nature of the nucleophile, either acyclic or cyclic derivatives were isolated. In the presence of primary amines, a short and efficient access to diazinic hemiaminals was described.
authors.affiliation: ICOA, UMR CNRS 6005, Université d'Orléans, 45067 Orléans Cedex 2, France.
authors.forename: Elise
authors.initials: E
authors.lastname: Claveau
authors.forename: Isabelle
authors.initials: I
authors.lastname: Gillaizeau
authors.forename: Justyna
authors.initials: J
authors.lastname: Kalinowska-Tluscik
authors.forename: Pascal
authors.initials: P
authors.lastname: Bouyssou
authors.forename: Gérard
authors.initials: G
authors.lastname: Coudert