title: Unsuspected exposure to cocaine in preschool children from a Mediterranean city detected by hair analysis.
abstract: We used hair testing to investigate the prevalence of unsuspected exposure to cocaine in a group of preschool children presenting to an urban pediatric emergency department without signs or symptoms suggestive of exposure. Hair samples were obtained from 90 children between 18 months and 5 years of age attending the emergency room of Hospital del Mar in Barcelona, Spain. In 85 cases, hair samples from the accompanying parent were also provided. The samples were analyzed for the presence of cocaine and benzoylecgonine by gas chromatography-mass spectrometry, which also determined opiates and amphetamines. Parental sociodemographics, possible drug history, and information on the child's features were recorded. Hair samples from 21 children (23.3%) were positive for cocaine (concentration range 0.3-5.96 ng/mg of hair) with 1 sample also positive for 3,4-methylenedioxymethamphetamine and another for opiates. In 88% of the positive cases, cocaine was also found in the hair of the accompanying parent (15 of 17 matched parent-child hair samples). Parental sociodemographics were associated neither with children's exposure to cocaine nor with somatometry of children at birth. However, the behavioral patterns with potential harmful effects for the child's health (eg, tobacco smoking, cannabis, benzodiazepines and/or antidepressants use, and shorter breast-feeding time) were significantly higher in the parents of exposed children. A statistically higher percentage of exposed children were in the lower weight percentile group compared with the nonexposed children. In the light of these results, we advocate general hair screening to disclose exposure to cocaine and other drugs of abuse in children from risky environments, which could provide the basis for specific social and health interventions.
authors.affiliation: Unitat de Recerca Infància i Entorn, Institut Municipal d'Investigació Mèdica-Hospital del Mar, Barcelona, Spain.
authors.forename: Xavier
authors.initials: X
authors.lastname: Joya
authors.forename: Esther
authors.initials: E
authors.lastname: Papaseit
authors.forename: Ester
authors.initials: E
authors.lastname: Civit
authors.forename: Manuela
authors.initials: M
authors.lastname: Pellegrini
authors.forename: Oriol
authors.initials: O
authors.lastname: Vall
authors.forename: Oscar
authors.initials: O
authors.lastname: Garcia-Algar
authors.forename: Giulia
authors.initials: G
authors.lastname: Scaravelli
authors.forename: Simona
authors.initials: S
authors.lastname: Pichini