Comparing outcomes in patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration treated with two different doses of primary intravitreal bevacizumab: results of the Pan-American Collaborative Retina Study Group (PACORES) at the 12-month follow-up.
OBJECTIVE
To compare the total number of injections and the anatomic and best-corrected visual acuity (VA) response after injecting 1.25 or 2.5 mg of bevacizumab as needed in patients with primary choroidal neovascularization secondary to age-related macular degeneration (AMD) at 12 months.


METHODS
This was a retrospective, interventional, comparative multicenter study of 60 eyes treated with intravitreal bevacizumab (35 eyes, 1.25 mg; 25 eyes, 2.5 mg).


RESULTS
The mean number of injections per eye was 3.8 in the 1.25-mg group and 3.2 in the 2.5-mg group (P = 0.2752). At 12 months, in the 1.25-mg group, 16 (46%) eyes gained > or =3 lines of Early Treatment Diabetic Retinopathy Study (ETDRS) VA and seven (20%) lost > or =3 lines of ETDRS VA. In the 2.5-mg group, 11 (44%) eyes improved by > or =3 lines, and four (16%) lost > or =3 lines (P = 1.000). At 12 months, in the 1.25-mg group, the mean central macular thickness decreased from 419 +/- 201 microm at baseline to 268 +/- 96 microm, compared with a decrease from 388 +/- 162 to 296 +/- 114 microm in the 2.5-mg group (P = 0.7896).


CONCLUSIONS
There were no statistically significant differences between the two dose groups with regard to the number of injections, anatomic and VA outcomes.
Wu
Lihteh
L
Instituto de Cirugia Ocular, San Jose, Costa Rica. LW65@CORNELL.EDU.|, Apdo 144-1225 Plaza Mayor, San Jose, Costa Rica, 1225. LW65@CORNELL.EDU.
Fernando Arevalo
J
J
Retina and Vitreous Service, Clinica Oftalmológica Centro Caracas, Caracas, Venezuela.
Maia
Mauricio
M
Departamento de Oftalmologia, Instituto da Visão, Universidade Federal de São Paulo, São Paulo, Brazil.
Berrocal
Maria H
MH
University of Puerto Rico, San Juan, Puerto Rico.
Sanchez
Juan
J
Retina and Vitreous Service, Clinica Oftalmológica Centro Caracas, Caracas, Venezuela.
Evans
Teodoro
T
Instituto de Cirugia Ocular, San Jose, Costa Rica.