title: Synthesis of 2-alkyl-substituted chromone derivatives using microwave irradiation.
abstract: A base-promoted condensation between 2-hydroxyacetophenones and aliphatic aldehydes has been studied. The reaction has been optimized to afford 2-alkyl-substituted 4-chromanones in an efficient manner using microwave heating. Performing the reaction using diisopropylamine in EtOH at 170 degrees C for 1 h gave moderate to high yields (43-88%). The 4-chromanones could be further converted into highly functionalized 2,3,6,8-tetrasubstituted chromones in which a 3-substituent (acetate, amine, or bromine) was introduced via straightforward chemical transformations.
authors.affiliation: Department of Chemistry, Medicinal Chemistry, University of Gothenburg, SE-41296 Goteborg, Sweden.
authors.forename: Maria
authors.initials: M
authors.lastname: Fridén-Saxin
authors.forename: Nils
authors.initials: N
authors.lastname: Pemberton
authors.forename: Krystle da Silva
authors.initials: Kda S
authors.lastname: Andersson
authors.forename: Christine
authors.initials: C
authors.lastname: Dyrager
authors.forename: Annika
authors.initials: A
authors.lastname: Friberg
authors.forename: Morten
authors.initials: M
authors.lastname: Grøtli
authors.forename: Kristina
authors.initials: K
authors.lastname: Luthman