title: Absence of deleterious palladin mutations in patients with familial pancreatic cancer.
abstract: It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.
authors.affiliation: Department of Pathology, The John Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Alison P
authors.initials: AP
authors.lastname: Klein
authors.forename: Michael
authors.initials: M
authors.lastname: Borges
authors.forename: Margaret
authors.initials: M
authors.lastname: Griffith
authors.forename: Kieran
authors.initials: K
authors.lastname: Brune
authors.forename: Seung-Mo
authors.initials: SM
authors.lastname: Hong
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Omura
authors.forename: Ralph H
authors.initials: RH
authors.lastname: Hruban
authors.forename: Michael
authors.initials: M
authors.lastname: Goggins