The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents.
A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.
Lam
Kim Hung
KH
Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hong Kong, China. bcjoelam@inet.polyu.edu.hk
Gambari
Roberto
R
Yuen
Marcus Chun Wah
MC
Kan
Chi Wai
CW
Chan
Penni
P
Xu
Lijin
L
Tang
Weijun
W
Chui
Chung Hin
CH
Cheng
Gregory Yin Ming
GY
Wong
Raymond Siu Ming
RS
Lau
Fung Yi
FY
Tong
Cindy Sze Wai
CS
Chan
Andrew Kit Wah
AK
Lai
Paul Bo San
PB
Kok
Stanton Hon Lung
SH
Cheng
Chor Hing
CH
Chan
Albert Sun Chi
AS
Tang
Johnny Cheuk On
JC