title: Enantioselective conjugate addition of nitroalkanes to vinyl sulfone: an organocatalytic access to chiral amines.
abstract: Organocatalytic asymmetric conjugate addition of nitroalkanes to vinyl sulfone mediated by cinchona alkaloid-derived thiourea catalyst afforded the desired Michael product with good enantioselectivity. The described method, in combination with ready desulfonation, represents a novel approach to access alpha-alkylated chiral amines.
authors.affiliation: Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu