title: Breviane spiroditerpenoids from an extreme-tolerant Penicillium sp. isolated from a deep sea sediment sample.
abstract: Breviones F-H (1-3), three new bioactive breviane spiroditerpenoids, have been isolated from the crude extract of an extreme-tolerant Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of these compounds were elucidated primarily by NMR spectroscopy. The absolute configurations of 1 and 3 were assigned by application of the modified Mosher method, and 3 is further confirmed by X-ray crystallographic analysis of its S-MTPA ester. Compound 2 could be the precursor for 3, which features a previously undescribed skeleton of mixed biogenesis.
authors.affiliation: Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Dezan
authors.initials: D
authors.lastname: Ye
authors.forename: Xulin
authors.initials: X
authors.lastname: Chen
authors.forename: Xinhua
authors.initials: X
authors.lastname: Lu
authors.forename: Zongze
authors.initials: Z
authors.lastname: Shao
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che