Secondary generalization in seizures of temporal lobe origin: Ictal EEG pattern in a stereo-EEG study.
OBJECTIVE
We tested the hypothesis that secondary generalized seizures (SGS) are not truly generalized and may involve selective regions.


METHODS
The spread from focal to generalized seizures in temporal lobe epilepsy (TLE) was studied in 20 SGS recorded via stereo-EEG (SEEG) in 15 candidates for surgery. Electrodes were assigned to fronto-orbital, prefrontal, and temporal cortex, cingulate, hippocampus, and amygdala. The onset of SGS was ascertained by behavioral analysis of the video recordings. EEG recordings were evaluated using the rating scale developed by Blumenfeld [Blumenfeld H, Rivera M, McNally KA, Davis K, Spencer DD, Spencer SS. Ictal neocortical slowing in temporal lobe epilepsy. Neurology 2004;63:1015-21]. The seizure rating in each region was compared with the rating in the hippocampus.


RESULTS
Ranking significantly differed in the cingulate and fronto-orbital cortex; there was a trend toward significance in the prefrontal cortex. In these regions, slow activity dominated.


CONCLUSIONS
The onset of secondary generalization, when the head, face and all limbs are involved, does not implicate global cortical involvement.
Rektor
Ivan
I
First Department of Neurology, Masaryk University, St. Anne's Hospital, Pekarská 53, Brno 656 91, Czech Republic. irektor@med.muni.cz
Zákopcan
Jozef
J
Tyrlíková
Ivana
I
Kuba
Robert
R
Brázdil
Milan
M
Chrastina
Jan
J
Novák
Zdenĕk
Z