title: The regio- and stereoselective synthesis of trans-2,3-dihydropyridine N-oxides and piperidines.
abstract: Reactivity N-Own: Pyridine N-oxides can be used for the complete regio- and stereoselective synthesis of trans-substituted piperidines. The sequential addition of Grignard reagents and aldehydes or ketones to pyridine N-oxides yields a complete regio- and stereoselective trans 2,3-addition reaction in high yields, and the substituted 2,3-dihydropyridine N-oxide can be reduced to form 2,3-trans-substituted piperidines (see scheme).
authors.affiliation: Department of Chemistry, Umeå University, Petrus lestadius väg, 90187 Umeå, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Andersson
authors.forename: Magnus
authors.initials: M
authors.lastname: Gustafsson
authors.forename: Dan
authors.initials: D
authors.lastname: Boström
authors.forename: Roger
authors.initials: R
authors.lastname: Olsson
authors.forename: Fredrik
authors.initials: F
authors.lastname: Almqvist