TMPZnCl.LiCl: a new active selective base for the directed zincation of sensitive aromatics and heteroaromatics.
A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF via direct zincation using TMPZnCl.LiCl, a new exceptionally mild and efficient base. Activated arenes and heteroarenes are metalated at room temperature. Remarkably, sensitive functions such as an aldehyde as well as a nitro group are tolerated, expanding significantly the scope of directed metalations.
Mosrin
Marc
M
Department Chemie & Biochemie, Ludwig-Maximilians-Universitat, Butenandtstrasse 5-13, 81377 Munchen, Germany.
Knochel
Paul
P