title: A monocyte chemoattractant protein-1 gene polymorphism is not associated with coronary artery disease in a Han Chinese population.
abstract: BACKGROUND
  Coronary artery disease (CAD) is one of the most common forms of heart diseases. Monocyte chemoattractant protein-1 gene (MCP-1, CCL2) has been considered one of the candidate genes that play a role in atherogenesis of CAD. Recently, the association of a single nucleotide polymorphism (SNP) in the MCP-1 gene promoter (-2518A>G) and CAD has been investigated with controversial results.
  
  
  METHODS
  The -2518A>G polymorphism of MCP-1 was determined in 502 CAD patients and 410 control subjects to investigate the possible involvement of MCP-1 in CAD.
  
  
  RESULTS
  No significant differences in the genotype or allele frequencies were revealed between subjects with and without CAD (P=0.581 and 0.310, respectively). Further stratification analysis by gender or age and analysis of clinical features in relation to myocardial infarction also yielded negative results.
  
  
  CONCLUSIONS
  -2518A>G polymorphism of MCP-1 does not seem to contribute substantially to CAD in Han Chinese.
authors.affiliation: Department of Cardiology, Cardiovascular Research Institute, Northern Hospital, Shenyang 110016, China.
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Zhang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Han
authors.forename: Jian
authors.initials: J
authors.lastname: Kang
authors.forename: Chenghui
authors.initials: C
authors.lastname: Yan