title: Decomposition Analyses Applied to a Complex Ultradian Biorhythm: The Oscillating NADH Oxidase Activity of Plasma Membranes Having a Potential Time-Keeping (Clock) Function.
abstract: Seasonal decomposition analyses were applied to the statistical evaluation of an oscillating activity for a plasma membrane NADH oxidase activity with a temperature compensated period of 24 min. The decomposition fits were used to validate the cyclic oscillatory pattern. Three measured values, average percentage error (MAPE), a measure of the periodic oscillation, mean average deviation (MAD), a measure of the absolute average deviations from the fitted values, and mean standard deviation (MSD), the measure of standard deviation from the fitted values plus R-squared and the Henriksson-Merton p value were used to evaluate accuracy.Decomposition was carried out by fitting a trend line to the data, then detrending the data if necessary, by subtracting the trend component. The data, with or without detrending, were then smoothed by subtracting a centered moving average of length equal to the period length determined by Fourier analysis. Finally, the time series were decomposed into cyclic and error components. The findings not only validate the periodic nature of the major oscillations but suggest, as well, that the minor intervening fluctuations also recur within each period with a reproducible pattern of recurrence.
authors.affiliation: Department of Agricultural Economics, Department of Medicinal Chemistry and Molecular Pharmacology.
authors.forename: Ken
authors.initials: K
authors.lastname: Foster
authors.forename: Nasim
authors.initials: N
authors.lastname: Anwar
authors.forename: Rhea
authors.initials: R
authors.lastname: Pogue
authors.forename: Dorothy M
authors.initials: DM
authors.lastname: Morré
authors.forename: T W
authors.initials: TW
authors.lastname: Keenan
authors.forename: D James
authors.initials: DJ
authors.lastname: Morré