Gastroesophageal reflux disease and management in advanced pregnancy: a prospective survey.
BACKGROUND
Heartburn is known to be common during pregnancy, however validated data on gastroesophageal reflux disease (GERD) are missing. The aim of this survey was to study the prevalence of GERD, the frequency and severity of typical GERD symptoms, and their impact on quality of life and therapeutic management in advanced pregnancy.


METHODS
One hundred and thirty-five consecutive pregnant women in the third trimester were included in a prospective study using validated questionnaires: RDQ, QOLRAD and a self-administered questionnaire detailing sociodemographic factors.


RESULTS
The prevalence for GERD in this unselected population was 56.3%. Among symptoms regurgitation was the most frequent with 47.3%, whereas heartburn was graded as the most severe symptom. The impact of GERD on the QOL of the pregnant women was significant (p < 0.001). 22.9% of the GERD population required medication because of severe symptoms, often reported to be insufficient for symptoms relief.


CONCLUSIONS
GERD is common in late pregnancy with an important negative impact on the QOL. GERD in advanced pregnancy deserves more attention and better therapeutic management.
Fill Malfertheiner
Sara
S
Department of Obstetrics and Gynecology, Otto-von-Guericke University, Magdeburg, Gerhart-Hauptmann-Strasse 35, DE-39108 Magdeburg, Germany. sara.fill-malfertheiner@med.ovgu.de
Malfertheiner
Maximilian Valentin
MV
Mönkemüller
Klaus
K
Röhl
Friedrich-Wilhelm
FW
Malfertheiner
Peter
P
Costa
Serban-Dan
SD