title: Intricate links between ER stress and apoptosis.
abstract: Bax inhibitor-1 (BI-1) interacts with Bax, neutralizing its proapoptotic activity. In this issue of Molecular Cell, Lisbona et al. (2009) show that BI-1 directly inhibits IRE1alpha, an essential mediator of the UPR, thereby facilitating crosstalk between apoptosis and ER stress pathways.
authors.affiliation: Institute of Molecular Biosciences, University of Graz, 8010 Graz, Austria.
authors.forename: Frank
authors.initials: F
authors.lastname: Madeo
authors.forename: Guido
authors.initials: G
authors.lastname: Kroemer