Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
van Haaften
Gijs
G
Wellcome Trust Sanger Institute, Hinxton, UK.
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Gillian L
GL
Davies
Helen
H
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L
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Graham
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Chris
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S
Hardy
Claire
C
O'Meara
Sarah
S
Teague
Jon
J
Butler
Adam
A
Hinton
Jonathan
J
Latimer
Calli
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Jenny
J
Barthorpe
Syd
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Beare
Dave
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Gemma
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Campbell
Peter J
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Jennifer
J
Forbes
Simon
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Jia
Mingming
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Kok
Chai Yin
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Leroy
Catherine
C
Lin
Meng-Lay
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McBride
David J
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Simon
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McLay
Kirsten
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Menzies
Andrew
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Mironenko
Tatiana
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Mulderrig
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Mudie
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Pleasance
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Shepherd
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Smith
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Turner
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Sofie
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Widaa
Sara
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Wray
Paul
P
Collins
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VP
Ichimura
Koichi
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Law
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ST
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Yu-Tzu
YT
Anderson
Kenneth C
KC
Kahnoski
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RJ
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SK
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Bin Tean
BT
Stratton
Michael R
MR
Futreal
P Andrew
PA