Restoration of chemosensitivity by bortezomib: implications for refractory myeloma.
BACKGROUND
A 59-year-old woman presented to the emergency department with a left rib fracture and was diagnosed with IgA multiple myeloma. The patient underwent autologous bone-marrow transplantation, and 14 months later she developed obstructive jaundice.


METHODS
Serum protein electrophoresis, contrast CT of thorax and abdomen, endoscopic retrograde cholangiopancreatography with endoscopic biopsy and pleural biopsy.


METHODS
Extramedullary plasmacytomas at pancreatic head and pleura.


RESULTS
Salvage chemotherapy regimens including bortezomib plus steroid, alkylators plus steroid, bortezomib plus anthracycline and radiotherapy, and combined bortezomib, cyclophosphamide, melphalan and steroid therapy.
Chim
Chor Sang
CS
Department of Medicine, Queen Mary Hospital, Hong Kong. jcschim@hku.hk
Hwang
Yu Yan
YY
Pang
Clara
C
Shek
Tony W
TW