title: Extracellular matrix binding mixed micelles for drug delivery applications.
abstract: We present the formation of collagen-binding mixed micelles and their potential suitability to deliver therapeutic drugs to the vessel wall. We modified poly(ethylene oxide)-bl-poly(propylene oxide)-bl-poly(ethylene oxide) (Pluronic F-127) to display sulfate groups on the terminus of the PEO block to act as a heparin mimics and bind to collagen in the extracellular matrix. This functionalized macroamphiphile was incorporated into a mixed micelle with poly(propylene sulfide)-bl-poly(ethylene oxide), a macroamphiphile that demonstrates improved micellar stability relative to Pluronic F-127 micelles. The mixed micelles were examined using analytical ultracentrifugation, dynamic light scattering, transmission electron microscopy, and measures of the critical micellar concentration using surface tensiometry. Encapsulation and in vitro release of Sirolimus, an immunosuppressant drug of interest in coronary artery treatment, was considered as an example. Mixed micelles with the sulfate functionality demonstrated enhanced binding to collagen I coated surfaces, suggestive of the potential for binding to the extracellular milieu.
authors.affiliation: Institute for Bioengineering and Institute for Chemical Sciences and Engineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 15, CH-1015 Lausanne, Switzerland.
authors.forename: Conlin P
authors.initials: CP
authors.lastname: O'Neil
authors.forename: André J
authors.initials: AJ
authors.lastname: van der Vlies
authors.forename: Diana
authors.initials: D
authors.lastname: Velluto
authors.forename: Christine
authors.initials: C
authors.lastname: Wandrey
authors.forename: Davide
authors.initials: D
authors.lastname: Demurtas
authors.forename: Jacques
authors.initials: J
authors.lastname: Dubochet
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Hubbell