title: Doubly dearomatising intramolecular coupling of a nucleophilic and an electrophilic heterocycle.
abstract: Isonicotinamides carrying N-furanylmethyl, N-pyrrolylalkyl or N-thiophenylmethyl substituents at nitrogen undergo cyclisation induced by an electrophile, giving spirocyclic compounds or doubly spirocyclic compounds in which both the nucleophilic and electrophilic heterocycles are dearomatised.
authors.affiliation: School of Chemistry, University of Manchester, Oxford Road, Manchester, UKM13 9PL.
authors.forename: Heloise
authors.initials: H
authors.lastname: Brice
authors.forename: Jonathan
authors.initials: J
authors.lastname: Clayden