title: Angiocentric glioma: a case series.
abstract: OBJECTIVE
  Angiocentric glioma was recently recognized as a distinct clinicopathological entity in the 2007 World Health Organization Classification of Tumours of the Central Nervous System. The authors present the first 3 pediatric cases of angiocentric glioma encountered at their institution and review the literature of reported cases to elucidate the characteristics and outcomes of pediatric patients with this novel tumor.
  
  
  METHODS
  The children in the 3 cases of angiocentric glioma were 10, 10, and 13 years old. Two presented with intractable seizures and 1 with worsening headache and several months of decreasing visual acuity. Twenty-five cases, including the 3 first described in the present paper, were culled from the literature.
  
  
  RESULTS
  In all 3 cases, MR imaging demonstrated a superficial, nonenhancing, T2-hyperintense lesion in the left temporal lobe. Histologically, the tumors were composed of monomorphous cells with a strikingly perivascular orientation that were variably reactive for glial fibrillary acidic protein and epithelial membrane antigen. Surgical treatment resulted in gross-total resection in all 3 cases. By 24, 9, and 6 months after surgery, all 3 patients remained seizure free without focal neurological deficits.
  
  
  CONCLUSIONS
  Among 25 cases of angiocentric glioma, seizure was the most common symptom at presentation. Magnetic resonance imaging demonstrated supratentorial, nonenhancing, T1-hypointense, T2-hyperintense lesions. Gross-total resection of this lesion yields excellent results.
authors.affiliation: Departments of Neurosurgery John Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Sophia F
authors.initials: SF
authors.lastname: Shakur
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: McGirt
authors.forename: Michael W
authors.initials: MW
authors.lastname: Johnson
authors.forename: Peter C
authors.initials: PC
authors.lastname: Burger
authors.forename: Edward
authors.initials: E
authors.lastname: Ahn
authors.forename: Benjamin S
authors.initials: BS
authors.lastname: Carson
authors.forename: George I
authors.initials: GI
authors.lastname: Jallo