title: An infant with self-healing cutaneous Langerhans cell histiocytosis followed by isolated thymic relapse.
abstract: Thymic involvement with Langerhans cell histiocytosis (LCH) typically occurs in children as part of multi-system (M-S) LCH. Patients who develop skin-only LCH during infancy may either follow a self-healing course with spontaneous regression or may progress to M-S involvement. We describe a male infant who developed isolated thymic LCH after spontaneous complete regression of isolated cutaneous lesions. His erythrocyte sedimentation rate and C-reactive protein increased temporarily during the skin-only stage of LCH, and increased again considerably during the thymic relapse. Even for patients with skin-only LCH, these laboratory data might indicate possible relapse or late progression of the disease.
authors.affiliation: Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan. nhatake@sapmed.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Hatakeyama
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Hori
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Ineko
authors.initials: I
authors.lastname: Sogawa
authors.forename: Natsuko
authors.initials: N
authors.lastname: Inazawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsutsumi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki