title: Two new 11(15-->1)abeotaxanes with a 2,20-epoxy ring from the needles of Taxus canadensis.
abstract: Two 11(15-->1)abeotaxanes having a tetrahydrofuran ring along the carbon atoms C-2, C-3, C-4, C-20 were identified for the first time from the needles of the Canadian yew, Taxus canadensis. The compounds could be identified as 4alpha,10beta,13alpha-triacetoxy-15-benzoyloxy-2alpha,20beta-epoxy-11(15-->1)abeotax-11-ene-5alpha,7beta,9alpha-triol (1) and 4alpha,7beta,9alpha,10beta,15-pentaacetoxy-2alpha,20beta-epoxy-11(15-->1)abeotax-11-ene-5alpha,13alpha-diol (2) on the basis of 1D-, 2D-NMR evidence and high-resolution FABMS analysis. Compound 1 showed weak growth inhibitory activities against T-98 and MM1-CB cells in vitro.
authors.affiliation: School of Pharmaceutical Sciences and College of Basic Medical Sciences, Hebei Medical University, 361 Zhongshan East Road, 050017, Shijiazhuang, Hebei Province, P. R. China.
authors.forename: Man-Li
authors.initials: ML
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Mei
authors.initials: M
authors.lastname: Dong
authors.forename: Shu-Hua
authors.initials: SH
authors.lastname: Feng
authors.forename: Chang-Hong
authors.initials: CH
authors.lastname: Huo
authors.forename: Françoise
authors.initials: F
authors.lastname: Sauriol
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Shi
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Kiyota
authors.forename: Bin
authors.initials: B
authors.lastname: Cong