title: Conferols A and B, new anti-inflammatory 4-hydroxyisoflavones from Caragana conferta.
abstract: Conferols A (1) and B (2), the new 4-hydroxyisoflavones, have been isolated from the dichloromethane sub-fraction of the methanolic extract of Caragana conferta along with 3',5'-dihydroxy, 7,4'-dimethoxyisoflavone (3), E-cinnamic acid (4), tetracosyl 3,4-dihydroxy-E-cinnamate (5), docosyl 3,4-dihydroxy-E-cinnamate (6), beta-sitosterol (7), beta-sitostrerol 3-O-beta-D-glucopyranoside (8), stigmasterol (9) and lupeol (10), respectively, reported for the first time from this species. The structures of the new compounds were elucidated through spectroscopic techniques including MS and 2D-NMR. The compounds 1-3 showed significant anti-inflammatory activity in the respiratory burst assay.
authors.affiliation: International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Rehan
authors.initials: R
authors.lastname: Khan
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Achyut
authors.initials: A
authors.lastname: Adhikari
authors.forename: Mohammad Irfan
authors.initials: MI
authors.lastname: Qadir
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary