The first asymmetric Sonogashira coupling for the enantioselective generation of planar chirality in paracyclophanes.
The double Sonogashira coupling of diiodoparacyclophanes with alkynes proceeded to give planarly chiral dialkynylparacyclophanes; a chiral Pd catalyst, which was prepared in situ from PdCl(2)(CH(3)CN)(2) and Taniaphos, realized the first asymmetric Sonogashira coupling with up to ca. 80% ee.
Kanda
Kazumasa
K
Department of Chemistry and Biochemistry, Waseda University, Shinjuku, Tokyo, 169-8555, Japan.
Koike
Tamami
T
Endo
Kohei
K
Shibata
Takanori
T