title: [Multiple spontaneous cerebral haemorrhages. Description of a series and review of the literature].
abstract: BACKGROUND
  The simultaneous occurrence of intracerebral haemorraghes in different arterial territories is an clinical event that develops in 2% to 3% of hemorrhagic strokes. Multiple risk factors have been associated with multiple intracerebral haemorraghes, but none of them are clearly defined. We reported clinical features, radiological findings, and outcome of 7 patients admitted to our department during last nine years and the diverse etiologic factors are discussed.
  
  
  METHODS
  We retrospectively reviewed all patients with acute stroke admitted to our department during the period January 1998-February 2007. Patients with a history of traumatic brain injury or suspected hemorrhagic infarctions were excluded. We collected data concerning age, risk factors, clinical features, number and location of haematomas and outcome.
  
  
  RESULTS
  We studied 7 patients (5 males and 2 females) Mean age was 78. The most common clinical manifestations were decreased alertness and weakness. Total number of haematomas was 20, 19 (95%) supratentorial and 15 (75%) in lobar area. One patient haemorrhage extended into the ventricular system. Three patients (43%) had hipertensive history, and in only one case was associated with oral anticoagulant (14%) and one blood dyscrasia (14%). Three patients died (43%).
  
  
  CONCLUSIONS
  In our series of patients with multiple intracerebral haemorraghes, clinical and radiological findings and outcome were comparable to others previously described, but our patients were older. The advanced age and lobar localization suggest amyloid angiopathy is an important risk factor to multiple intracerebral haemorraghes.
authors.affiliation: Servicio de Medicina Interna, Complejo Asistencial de Palencia, Palencia, España.
authors.forename: M A
authors.initials: MA
authors.lastname: Tejero
authors.forename: A L
authors.initials: AL
authors.lastname: Guerrero-Peral
authors.forename: F
authors.initials: F
authors.lastname: Iglesias
authors.forename: F
authors.initials: F
authors.lastname: Gutiérrez-Martín
authors.forename: J
authors.initials: J
authors.lastname: Martín-Polo
authors.forename: F
authors.initials: F
authors.lastname: Sánchez-Barranco
authors.forename: E
authors.initials: E
authors.lastname: Laherrán
authors.forename: J I
authors.initials: JI
authors.lastname: Martín-Serradilla