title: Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma.
abstract: A mutational analysis of the matrix metalloproteinase (MMP) gene family in human melanoma identified somatic mutations in 23% of melanomas. Five mutations in one of the most commonly mutated genes, MMP8, reduced MMP enzyme activity. Expression of wild-type but not mutant MMP8 in human melanoma cells inhibited growth on soft agar in vitro and tumor formation in vivo, suggesting that wild-type MMP-8 has the ability to inhibit melanoma progression.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Lavanya H
authors.initials: LH
authors.lastname: Palavalli
authors.forename: Todd D
authors.initials: TD
authors.lastname: Prickett
authors.forename: John R
authors.initials: JR
authors.lastname: Wunderlich
authors.forename: Xiaomu
authors.initials: X
authors.lastname: Wei
authors.forename: Allison S
authors.initials: AS
authors.lastname: Burrell
authors.forename: Patricia
authors.initials: P
authors.lastname: Porter-Gill
authors.forename: Sean
authors.initials: S
authors.lastname: Davis
authors.forename: Chenwei
authors.initials: C
authors.lastname: Wang
authors.forename: Julia C
authors.initials: JC
authors.lastname: Cronin
authors.forename: Neena S
authors.initials: NS
authors.lastname: Agrawal
authors.forename: Jimmy C
authors.initials: JC
authors.lastname: Lin
authors.forename: Wendy
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authors.lastname: Westbroek
authors.forename: Shelley
authors.initials: S
authors.lastname: Hoogstraten-Miller
authors.forename: Alfredo A
authors.initials: AA
authors.lastname: Molinolo
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authors.lastname: Fetsch
authors.forename: Armando C
authors.initials: AC
authors.lastname: Filie
authors.forename: Michael P
authors.initials: MP
authors.lastname: O'Connell
authors.forename: Carolyn E
authors.initials: CE
authors.lastname: Banister
authors.forename: Jason D
authors.initials: JD
authors.lastname: Howard
authors.forename: Phillip
authors.initials: P
authors.lastname: Buckhaults
authors.forename: Ashani T
authors.initials: AT
authors.lastname: Weeraratna
authors.forename: Lawrence C
authors.initials: LC
authors.lastname: Brody
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rosenberg
authors.forename: Yardena
authors.initials: Y
authors.lastname: Samuels