Mutation-prone points in KCNQ.
BACKGROUND
KCNQ channels play important roles in controlling membrane excitability. A reduction in KCNQ channel activity due to genetic mutation is responsible for various human diseases, including arrhythmia.


METHODS
A combined bioinformatics analysis was performed to study the positions that are at risk for mutation within the amino acid sequence of KCNQ. A new bioinformatics tool, namely GlobPlot, was used.


RESULTS
According to the present study, the positions that are resistant to mutation are predicted.


CONCLUSIONS
Several mutation-prone positions within the KCNQ sequence are reported.
Wiwanitkit
Viroj
V
Wiwanitkit House, Bangkhae, Bangkok, Thailand.