New oral anticoagulants: not quite there yet.
The results of 3 large randomized trials of activated factor X inhibitors, for the prevention of venous thromboembolism, recently became available. Similar data for orally active thrombin inhibitors is also available from recent trials. In this review, we attempt to provide a balanced perspective on the relative merits and demerits of the new, orally active anticoagulants, and speculate on the future of these agents in clinical practice.
Karthikeyan
Ganesan
G
Department of Medicine, McMaster University, Hamilton, ON, Canada. karthik2010@gmail.com
Eikelboom
John W
JW
Hirsh
Jack
J