Genetic factors influence the clustering of depression among individuals with lower socioeconomic status.
OBJECTIVE
To investigate the extent to which shared genetic factors can explain the clustering of depression among individuals with lower socioeconomic status, and to examine if neuroticism or intelligence are involved in these pathways.


METHODS
In total 2,383 participants (1,028 men and 1,355 women) of the Erasmus Rucphen Family Study were assessed with the Center for Epidemiologic Studies Depression Scale (CES-D) and the Hospital Anxiety and Depression Scale (HADS-D). Socioeconomic status was assessed as the highest level of education obtained. The role of shared genetic factors was quantified by estimating genetic correlations (rhoG) between symptoms of depression and education level, with and without adjustment for premorbid intelligence and neuroticism scores.


RESULTS
Higher level of education was associated with lower depression scores (partial correlation coefficient -0.09 for CES-D and -0.17 for HADS-D). Significant genetic correlations were found between education and both CES-D (rhoG = -0.65) and HADS-D (rhoG = -0.50). The genetic correlations remained statistically significant after adjusting for premorbid intelligence and neuroticism scores.


CONCLUSIONS
Our study suggests that shared genetic factors play a role in the co-occurrence of lower socioeconomic status and symptoms of depression, which suggest that genetic factors play a role in health inequalities. Further research is needed to investigate the validity, causality and generalizability of our results.
López-León
Sandra
S
Genetic-Epidemiology Unit, Department of Epidemiology & Biostatistics and Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Choy
Wing Chi
WC
Aulchenko
Yurii S
YS
Claes
Stephan J
SJ
Oostra
Ben A
BA
Mackenbach
Johan P
JP
van Duijn
Cornelia M
CM
Janssens
A Cecile J W
AC