title: Fertility preservation in women with breast cancer undergoing adjuvant chemotherapy: a systematic review.
abstract: OBJECTIVE
  To investigate methods of fertility preservation in younger women exposed to adjuvant chemotherapy for breast cancer.
  
  
  METHODS
  Systematic review of literature.
  
  
  METHODS
  Academic Department of Medical Oncology.
  
  
  METHODS
  Premenopausal women exposed to adjuvant chemotherapy for breast cancer.
  
  
  METHODS
  Fertility preservation.
  
  
  RESULTS
  Data for fertility preservation in this setting come from nonrandomized trials and observational studies. The main methods of fertility preservation are ovarian protection by gonadotropin-releasing hormone (GnRH) agonists, cryopreservation of embryos after in vitro fertilization, and preservation of operatively sampled ovarian tissue or eggs after stimulation and puncture. Ongoing trials are assessing the role of ovarian protection by GnRH agonists.
  
  
  CONCLUSIONS
  At present, there are no high-level, evidence-based recommendations for preservation of fertility or of ovarian function in women with breast cancer. This is an important issue for young breast cancer survivors, and further studies are needed. Moreover, the interplay between ovarian protection by GnRH agonists and the efficacy of adjuvant chemotherapy remains elusive.
authors.affiliation: Department of Medical Oncology, Hospital AC Camargo, São Paulo, Brazil. marcelorscruz@uol.com.br
authors.forename: Marcelo R S
authors.initials: MR
authors.lastname: Cruz
authors.forename: Júlio C
authors.initials: JC
authors.lastname: Prestes
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Gimenes
authors.forename: Marcello F
authors.initials: MF
authors.lastname: Fanelli