title: Direct anti-selective catalytic asymmetric Mannich-type reactions of alpha-ketoanilides for the synthesis of gamma-amino amides and azetidine-2-amides.
abstract: Breaking with convention: A homodinuclear nickel complex derived from a biphenyldiamine-based Schiff base catalyzed an anti-selective Mannich-type reaction of alpha-ketoanilides (see scheme) to afford unique building blocks for the synthesis of azetidine-2-amides and alpha-hydroxy gamma-amino amides. This approach stands in contrast to conventional Mannich-type reactions for the synthesis of beta-amino carbonyl compounds. o-Ns = o-nitrobenzenesulfonyl.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Xu
authors.forename: Gang
authors.initials: G
authors.lastname: Lu
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Shibasaki