Homogeneous time-resolved fluoroimmunoassay for the measurement of midregional proadrenomedullin in plasma on the fully automated system B.R.A.H.M.S KRYPTOR.
OBJECTIVE
Evaluate the first automated assay measuring a mid regional fragment of the proadrenomedullin (MR-proADM).


METHODS
B.R.A.H.M.S MR-proADM KRYPTOR is a homogeneous assay.


RESULTS
In 144 healthy individuals, MR-proADM mean (SD) was measured at 0.37 nmol/L (0.09). High correlation with the manual assay, B.R.A.H.M.S MR-proADM LIA, was found on 281 samples from patients suffering from community acquired pneumonia (correlation coefficient 0.97).


CONCLUSIONS
This fast assay can be used in low respiratory tract infections.
Caruhel
Pascaline
P
Research and Development Department, CEZANNE SAS, Parc Scientifique Georges Besse, Nimes Cedex 1, France. pcaruhel@cezanne.fr
Mazier
Christian
C
Kunde
Jan
J
Morgenthaler
Nils G
NG
Darbouret
Bruno
B