Autologous stem-cell transplantation in patients with HIV-related lymphoma.
OBJECTIVE
Peripheral-blood autologous stem-cell transplantation (ASCT) in patients with HIV-related lymphoma (HIV-Ly) has been reported as a safe and useful procedure. Herein we report the European Group for Blood and Marrow Transplantation experience on patients with HIV-Ly undergoing ASCT.


METHODS
This was a retrospective, multicentric, registry-based analysis.


RESULTS
Since 1999, 68 patients from 20 institutions (median age, 41 years; range, 29 to 62 years) were included, diagnosed with non-Hodgkin's lymphoma (NHL; n = 50) or Hodgkin's lymphoma (n = 18). At the time of ASCT, 16 patients were in first complete remission (CR1); 44 patients were in CR more than 1, partial remission, or chemotherapy-sensitive relapse (chemo-S); and eight patients had chemotherapy-resistant disease. The median number of CD34(+) cells infused was 4.5 x 10(6)/kg (range, 1.6 to 21.2 x 10(6)/kg). Median time to neutrophil and platelet engraftment were 11 days (range, 8 to 36 days) and 14 days (range, 6 to 455 days), respectively, with a cumulative incidence (CI) at 1 year of 95.6% and 87%, respectively. CI of nonrelapse mortality (NRM) was 7.5% at 12 months after ASCT, mainly because of bacterial infections. CI of relapse was 30.4% at 24 months, statistically related with not being in CR at ASCT (relative risk [RR] = 3.6), NHL histology other than diffuse large B-cell lymphoma (RR = 3.4), and use of more than two previous treatment lines (RR = 3). At a median follow-up of 32 months (range, 2 to 81 months), progression-free survival (PFS) was 56%. Patients not in CR or with refractory disease at ASCT had poorer PFS (RR = 2.4 and 4.8, respectively).


CONCLUSIONS
Similarly to HIV-negative patients with lymphoma, ASCT is a useful treatment for patients with HIV-Ly and is associated with low NRM, mainly when performed in early stages and chemo-S disease.
Balsalobre
Pascual
P
Hospital General Universitario [corrected] Gregorio Marañón, Madrid, Spain.
Díez-Martín
José L
JL
Re
Alessandro
A
Michieli
Mariagrazia
M
Ribera
José M
JM
Canals
Carmen
C
Rosselet
Anne
A
Conde
Eulogio
E
Varela
Rosario
R
Cwynarski
Kate
K
Gabriel
Ian
I
Genet
Philippe
P
Guillerm
Gaelle
G
Allione
Bernardino
B
Ferrant
Augustin
A
Biron
Pierre
P
Espigado
Ildefonso
I
Serrano
David
D
Sureda
Anna
A