99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer--in vitro and in vivo results.
This study evaluated labelling efficiency and radiochemical purity of (99m)Tc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of (99m)Tc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2h eluate in vacuum or nitrogen. Labelling 26 MBq/microg (99m)Tc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.
Gommans
G M M
GM
Department of Nuclear Medicine, West-Fries Hospital Hoorn, The Netherlands. g.m.m.gommans@mca.nl
Gommans
E
E
van der Zant
F M
FM
Teule
G J J
GJ
van der Schors
T G
TG
de Waard
J W D
JW