title: Clinicopathologic analysis: relationship between endometrial carcinoma and uninvolved endometrium.
abstract: OBJECTIVE
  The aim of this study was to compare the histopathologic features and surgical stage of endometrial carcinoma with tumor-free endometrial tissues.
  
  
  METHODS
  Data from the files of 80 patients with endometrial carcinoma who were managed at Haseki Training & Research Hospital between January 2001 and July 2007 were evaluated. We assessed tumor-free endometrium, stage, histologic type and grade, depth of myometrial invasion, peritoneal cytology, adnexal-cervical involvement, lymphovascular space invasion (LVSI), and lymph node metastases.
  
  
  RESULTS
  Twenty-nine patients (43%) with endometrial carcinoma had concomitant endometrial hyperplasia. Seven patients (10%) had one or more areas of metaplasia in the endometrium adjacent to the carcinoma. Endometrial carcinoma with atrophic background was significantly associated with aggressive histopathologic type (p < 0.04) and LVSI (p < 0.02).
  
  
  CONCLUSIONS
  The histological characteristics of non-tumoral endometrium were found to be critical in determining the type of aggressive tumor and LVSI in atrophy-associated carcinomas.
authors.affiliation: Department of Gynecology & Obstetrics, Haseki Training & Research Hospital, Istanbul, Turkey. cemdane@yahoo.com
authors.forename: C
authors.initials: C
authors.lastname: Dane
authors.forename: Z
authors.initials: Z
authors.lastname: Tatar
authors.forename: B
authors.initials: B
authors.lastname: Dane
authors.forename: A
authors.initials: A
authors.lastname: Cetin