title: Improved survival in patients with breast rhabdoid tumors with multi-agent adjuvant chemotherapy combined with irradiation.
abstract: OBJECTIVE
  Malignant rhabdoid tumors (MRT) have poor prognoses. Breast MRT is extremely rare; only three cases have been documented, with a mean prognosis of 7 months. Multi-agent chemotherapy with mastectomy and irradiation, as used in this case, may extend survival in breast MRT.
  
  
  METHODS
  A 68-year-old woman who underwent a standard mastectomy was diagnosed with breast MRT. Postoperatively she received six cycles of cyclophosphamide/methotrexate/5-fluorouracil followed by oral administration of doxifluridine and anastrozole, after which no metastasis was detected. About 8 months postoperative, magnetic resonance imaging revealed cervical bone metastasis, and local irradiation and nine doses of "basic chemotherapy" consisting of biweekly paclitaxel and anastrozole were administered. About 4 months later, multiple lung metastases were revealed, and four doses of "basic chemotherapy" with added pirarubicin hydrochloride were administered. Four months after that, multiple large liver metastases were discovered, and five doses of "basic chemotherapy" with added carboplatin were administered.
  
  
  RESULTS
  The 19-month survival period of our case was almost three times that of reported breast MRT patients.
  
  
  CONCLUSIONS
  Multi-agent chemotherapy combined with irradiation may be associated with the relatively long survival of the present case.
authors.affiliation: Department of Surgery, Sodegaura Satsukidai Hospital, Sodegaura, Chiba, Japan. furuya@mail.satsuki-kai.or.jp
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Furuya
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yanagie
authors.forename: Takashi
authors.initials: T
authors.lastname: Wakahara
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Mishina
authors.forename: Harutoshi
authors.initials: H
authors.lastname: Akimoto
authors.forename: Le Minh
authors.initials: le M
authors.lastname: Quang
authors.forename: Kenzo
authors.initials: K
authors.lastname: Hiroshima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yasuhara