title: Multiple bone metastasis of sclerosing epithelioid fibrosarcoma 12 years after initial surgery-increasing ki-67 labeling index.
abstract: Sclerosing epithelioid fibrosarcoma (SEF) is a rare sarcoma of low-grade malignancy. There has been no report to describe the comparison of histological features of SEF between primary and metastatic lesions in spite of high local recurrence rate. We report the histological changes and increasing Ki-67 labeling index of the primary and metastatic lesions of SEF. The patient was a 31-year-old man. At 18, a tumor in the abdominal wall was excised. At 23, the tumor recurred which was removed again. At 30, he was referred to our hospital because of swelling and pain in the chest. Histological examination of the chest wall tumor showed epithelioid cells arranged like alveolar pattern with dense collagen stroma. These findings were consistent with those of SEF. Abdominal and the rib tumors showed the same immunohistochemistrical expression. It is noteworthy that the tumor cells of the rib lesion showed increased cellularity, and its Ki-67 activity was higher as compared with the abdominal tumor, suggestive of progression of malignancy of SEF.
authors.affiliation: Department of Orthopaedic Surgery, Tohoku University School of Medicine, Sendai 980-8574, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Kanno
authors.forename: Masahito
authors.initials: M
authors.lastname: Hatori
authors.forename: Masami
authors.initials: M
authors.lastname: Hosaka
authors.forename: Koshi N
authors.initials: KN
authors.lastname: Kishimoto
authors.forename: Munenori
authors.initials: M
authors.lastname: Watanuki
authors.forename: Mika
authors.initials: M
authors.lastname: Watanabe
authors.forename: Eiji
authors.initials: E
authors.lastname: Itoi