title: Enantioselective lactate binding by chiral tripodal anion hosts derived from amino acids.
abstract: Chiral, tripodal anion hosts derived from either S-phenylalanine or S-leucine bind D-lactate enantioselectively. The nature of the host-guest interaction has been probed by solution NMR methods and by DFT calculations. The calculations suggest that the D-lactate may form an additional hydrogen bond in the host-guest complex while the L-lactate complex contains an intramolecular hydrogen bond. Anion binding is in competition with host dimerisation, as demonstrated by DOSY and (1)H NMR spectroscopy, and DFT calculations.
authors.affiliation: Department of Chemistry, Durham University, South Road, Durham, UK DH1 3LE.
authors.forename: Anna
authors.initials: A
authors.lastname: Barnard
authors.forename: Sara Jane
authors.initials: SJ
authors.lastname: Dickson
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Paterson
authors.forename: Adam M
authors.initials: AM
authors.lastname: Todd
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Steed