title: Myocardial insulin-like growth factor-1 and insulin-like growth factor binding protein-3 gene expression in failing hearts harvested from patients undergoing cardiac transplantation.
abstract: Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) might play a pathogenic role in heart failure. We showed significantly increased myocardial IGFBP-3 expression (investigated by real-time polymerase chain reaction) and apoptosis (detected by flow cytometry) in 23 failing hearts from patients undergoing cardiac transplantation for end-stage dilated or ischemic cardiomyopathy, when compared with 10 controls. Higher IGF-1 mRNA levels were shown only in end-stage dilated cardiomyopathy.
authors.affiliation: Department of Pathology, Regina Margherita Hospital, Torino, Italy. angelapucci@libero.it
authors.forename: Angela
authors.initials: A
authors.lastname: Pucci
authors.forename: Cristina
authors.initials: C
authors.lastname: Zanini
authors.forename: Riccarda
authors.initials: R
authors.lastname: Granata
authors.forename: Roberta
authors.initials: R
authors.lastname: Ghignone
authors.forename: Alberto
authors.initials: A
authors.lastname: Iavarone
authors.forename: Fabio
authors.initials: F
authors.lastname: Broglio
authors.forename: Paolo
authors.initials: P
authors.lastname: Sorrentino
authors.forename: Laura
authors.initials: L
authors.lastname: Bergamasco
authors.forename: Mauro
authors.initials: M
authors.lastname: Rinaldi
authors.forename: Ezio
authors.initials: E
authors.lastname: Ghigo