title: Discovery and antibacterial activity of glabramycin A-C from Neosartorya glabra by an antisense strategy.
abstract: Treatment of drug-resistant bacteria is a significant unmet medical need. This challenge can be met only by the discovery and development of new antibiotics. Antisense technology is one of the newest discovery tools that provides enhanced sensitivity for detection of antibacterials, and has led to the discovery of a number of interesting new antibacterial natural products. Continued utilization of this technology led to the discovery of three new bicyclic lactones, glabramycins A-C, from a Neosartorya glabra strain. Glabramycin C showed strong antibiotic activity against Streptococcus pneumoniae (MIC 2 microg ml(-1)) and modest antibiotic activity against Staphylococcus aureus (MIC 16 microg ml(-1)). The isolation, structure, relative configuration and antibacterial activity, and plausible biogenesis of these compounds have been discussed.
authors.affiliation: Merck Research Laboratories, Rahway, NJ 7065, USA.
authors.forename: Hiranthi
authors.initials: H
authors.lastname: Jayasuriya
authors.forename: Deborah
authors.initials: D
authors.lastname: Zink
authors.forename: Angela
authors.initials: A
authors.lastname: Basilio
authors.forename: Francisca
authors.initials: F
authors.lastname: Vicente
authors.forename: Javier
authors.initials: J
authors.lastname: Collado
authors.forename: Gerald
authors.initials: G
authors.lastname: Bills
authors.forename: Mary Lee
authors.initials: ML
authors.lastname: Goldman
authors.forename: Mary
authors.initials: M
authors.lastname: Motyl
authors.forename: Joann
authors.initials: J
authors.lastname: Huber
authors.forename: Gabe
authors.initials: G
authors.lastname: Dezeny
authors.forename: Kevin
authors.initials: K
authors.lastname: Byrne
authors.forename: Sheo B
authors.initials: SB
authors.lastname: Singh