title: Synthesis, characterization and cytotoxicity of dihalogeno-platinum(II) complexes with L-histidine ligand.
abstract: Diiodo-, dibromo- and dichloro-platinum(II) complexes containing L-histidine ligand were prepared. Their spectra and X-ray crystal structure of the dibromo-platinum(II) complex were described. Only the dichloro-platinum(II) complex showed comparable cytotoxic activity with carboplatin against A549/ATCC, HT-29, and LNcap cell lines. Nevertheless the complexes with COOH-substituted ligands histidine may be good starting materials to synthesize targeting platinum complexes since they could be easily linked to suitable carrier molecules via esterification.
authors.affiliation: Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming, Yunnan, China.
authors.forename: Qing-Song
authors.initials: QS
authors.lastname: Ye
authors.forename: Ming-Jin
authors.initials: MJ
authors.lastname: Xie
authors.forename: Wei-Ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Xi-Zhu
authors.initials: XZ
authors.lastname: Chen
authors.forename: Yao
authors.initials: Y
authors.lastname: Yu
authors.forename: Qiao-Wen
authors.initials: QW
authors.lastname: Chang
authors.forename: Shu-Qian
authors.initials: SQ
authors.lastname: Hou