On the function and structure of synthetically modified porins.
The attachment of modulators to a trimeric porin ion channel was investigated (see picture of the trimer with a crown ether modulator (orange)). The interplay of modulator and protein is essential for the conformational heterogeneity of the hybrid channel. Single-site attachment in large pores is not sufficient to change the electrophysiological characteristics of the pores-such change requires additional noncovalent interactions or second-site attachments.
Reitz
Simon
S
Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
Cebi
Menekse
M
Reiss
Philipp
P
Studnik
Gregor
G
Linne
Uwe
U
Koert
Ulrich
U
Essen
Lars-Oliver
LO