title: The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator.
abstract: IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: D
authors.initials: D
authors.lastname: Kempuraj
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authors.initials: V
authors.lastname: Salini
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authors.lastname: Theoharides
authors.forename: D
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authors.lastname: De Amicis
authors.forename: A
authors.initials: A
authors.lastname: Perrella
authors.forename: C
authors.initials: C
authors.lastname: Cuccurullo
authors.forename: P
authors.initials: P
authors.lastname: Boscolo
authors.forename: Y
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authors.lastname: Shaik