Kinetics and prognostic value of inflammatory-sensitive protein, IL-6, and white blood cell levels in patients undergoing coronary stent implantation.
BACKGROUND
The levels of interleukin-6 (IL-6), white blood cells (WBCs), and some inflammatory-sensitive proteins (ISPs), such as fibrinogen (FIB) and C-reactive protein (CRP), have been related to coronary stent restenosis. The aim was to investigate the time course of the levels of IL-6, WBC, and several ISPs, i.e. FIB, CRP, cerruloplasmin (CER), haptoglobin (HPT), alpha-1 antitrypsin (A1AT), and alpha-1 acid glycoprotein (A1GP), after successful coronary stenting in patients with stable angina and to relate them to prognosis.


METHODS
FIB, CRP, IL-6, CER, HPT, A1AT, A1GP, and WBC levels were measured in 40 patients with stable angina before, and 6, 12, 24, 48, and 72 hours and 6 months after successful coronary stenting. The patients were followed up for 12 months.


RESULTS
FIB levels increased significantly (p<0.05) 48 hours, CRP and WBC count 24 hours, CER, HPT, A1AT, and A1GP 72 hours, and IL-6 6 hours after stenting. All the levels remained unchanged in 20 control patients undergoing coronary angiography. During follow-up, stent restenosis occurred in 7 patients. Time-course and mean values of all the studied substances did not significantly differ in patients with or without restenosis (p>0.05).


CONCLUSIONS
FIB, CRP, IL-6, CER, HPT, A1AT, A1GP, and WBC levels increase significantly after stenting, but they are not related to prognosis.
Ziakas
Alphantonios
A
1st Cardiology Department, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece. aziakas@med.auth.gr
Gavrilidis
Stavros
S
Giannoglou
George
G
Souliou
Efthimia
E
Koskinas
Konstantinos
K
Gemitzis
Konstantinos
K
Hatzimiltiadis
Stavros
S
Efthimiadis
George
G
Paraskevaidis
Stelios
S
Hatzitolios
Apostolos
A
Savopoulos
Christos
C
Parharidis
George
G