title: Calculation of apparent age by linear combination of facial  skin parameters: a predictive tool to evaluate the efficacy  of cosmetic treatments and to assess the predisposition  to accelerated aging.
abstract: The estimated apparent age (EAA) was estimated by a panel of trained experts, for the individuals in a cohort. Twelve independent clinical, biophysical and biochemical parameters measured on facial skin, have been identified by multiple regression analysis, which influence the EAA of a person of chronological age (CA) (under eye lines, clinically assessed crow's feet, age spots, clinically evaluated firmness, forehead lines, pores, lip lines, instrumentally evaluated firmness, instrumentally evaluated crow feet, skin texture, in vivo fluorescence related to proliferation and glycation). An algorithm has been devised to obtain the calculated age score (CAS) in a cohort of 452 female volunteers, as CAS(n) = ∑RCiPi(n) (i = 1-13, n = 1-452 and P13 = 1) where the coefficients Ci are obtained by minimizing the difference EAA - CAS, and Pi(n) are the experimental values of the i-th parameter for the n-th volunteer. The determination of CAS before and after a specific cosmetic or pharmacological anti-aging treatment can be used to objectively assess the efficacy of the treatment. The comparison of EAA(n) and of CAS(n) with CA(n) allows one to predict the susceptibility of an individual's face to undergo aging. It has been observed that the biophysical and biochemical parameters play a relevant role in the assessment of the predisposition of skin to undergo accelerated aging.
authors.affiliation: Estee Lauder Research Park, 125 Pinelawn Road, Melville, NY 11747, USA.
authors.forename: Denise
authors.initials: D
authors.lastname: Dicanio
authors.forename: Rose
authors.initials: R
authors.lastname: Sparacio
authors.forename: Lieve
authors.initials: L
authors.lastname: Declercq
authors.forename: Hugo
authors.initials: H
authors.lastname: Corstjens
authors.forename: Neelam
authors.initials: N
authors.lastname: Muizzuddin
authors.forename: Julie
authors.initials: J
authors.lastname: Hidalgo
authors.forename: Paolo U
authors.initials: PU
authors.lastname: Giacomoni
authors.forename: Lise
authors.initials: L
authors.lastname: Jorgensen
authors.forename: Daniel
authors.initials: D
authors.lastname: Maes