Protolimonoids from Melia toosendan.
Toosendanone A (1), a new euphane (tirucallane)-type triterpene bearing a five-membered ring in the side chain and the first cyclopentanyl protolimonoid, was isolated from the bark of Melia toosendan, along with two new tirucallanes, toosendanic acids A (2) and B (3). The structure and absolute configuration of compound 1 was elucidated by spectroscopic data interpretation and X-ray diffraction analysis. Compounds 1-3 were evaluated for cytotoxicity against a small panel of cancer cell lines.
Sang
Yi Shu
YS
Laboratory of Natural Products, Jiangsu Simcere Pharmaceutical R&D Company, Ltd, 699-18 Xuanwu Road, Xuanwu District, Nanjing 210042, People's Republic of China.
Zhou
Chun Yan
CY
Lu
Ai Jun
AJ
Yin
Xiao Jin
XJ
Min
Zhi Da
ZD
Tan
Ren Xiang
RX