Genetic variations in esophageal cancer risk and prognosis.
Investigations into inherited genetic variations in the DNA code (known as polymorphisms) in the field of oncology have provided preliminary support for an association with cancer risks and outcomes. Early studies have highlighted several genes with this potential predictive and prognostic power. However, these studies have had methodological limitations and have produced inconsistent results, making impractical as yet the routine evaluation of such genetic polymorphisms in general clinical practice. Continued research in this area is essential if we are to be able to soon use genetic polymorphisms to better select patients for targeted anticancer interventions. This review discusses the role of genetic polymorphisms and their association with esophageal cancer risk and prognosis. The article also highlights future directions in this new, emerging field of molecular epidemiology.
Cheung
Winson Y
WY
Medical Oncology and Hematology, Medicine, Princess Margaret Hospital/Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada.
Liu
Geoffrey
G