Reversible stability switching of a hairpin DNA via a photo-responsive linker unit.
We have designed and synthesized a novel photo-responsive linker unit, 4,4'-bis(hydroxymethyl)-azobenzene, which was introduced to the loop oligonucleotide in a DNA hairpin and was able to reversibly control the stability of the whole hairpin structure via UV or visible light irradiation.
Wu
Li
L
Frontier Institute for Biomolecular Engineering Research , Konan University, 8-9-1, Okamoto, Higashinada-ku, Kobe 658-8501, Japan.
Koumoto
Kazuya
K
Sugimoto
Naoki
N