title: Age-related changes in iron homeostasis in mouse ferroxidase mutants.
abstract: Disorders of iron metabolism are a significant problem primarily in young and old populations. In this study, We compared 1-year-old C57BL6/J mice on iron deficient, iron overload, or iron sufficient diets with two similarly aged genetic models of disturbed iron homeostasis, the sla (sex-linked anemia), and the ceruloplasmin knockout mice (Cp(-/-)) on iron sufficient diet. We found tissue specific changes in sla and nutritional iron deficiency including decreased liver Hamp1 expression and increased protein expression of the enterocyte basolateral iron transport components, hephaestin and ferroportin. In contrast, the Cp(-/-) mice did not show significantly increased Hamp1 expression despite increased liver iron suggesting that regulation is independent of liver iron levels. Together, these results suggest that older mice have a distinct response to alterations in iron metabolism and that age must be considered in future studies of iron metabolism.
authors.affiliation: Department of Nutritional Science and Toxicology, University of California, Berkeley, CA 94720-3104, USA.
authors.forename: Huijun
authors.initials: H
authors.lastname: Chen
authors.forename: Zouhair K
authors.initials: ZK
authors.lastname: Attieh
authors.forename: Hua
authors.initials: H
authors.lastname: Gao
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.forename: Trent
authors.initials: T
authors.lastname: Su
authors.forename: Weixiong
authors.initials: W
authors.lastname: Ke
authors.forename: Chris D
authors.initials: CD
authors.lastname: Vulpe