title: Demineralized bone matrix and resorbable mesh bilaminate cranioplasty: a novel method for reconstruction of large-scale defects in the pediatric calvaria.
abstract: BACKGROUND
  Pediatric patients with large-scale calvarial defects often lose the osteogenic potential of their dura before developing a diploic space sufficient to facilitate harvest of split-thickness calvarial grafts. The authors present their experience using demineralized bone matrix and resorbable mesh bilaminate for the repair of large-scale cranial defects in pediatric patients.
  
  
  METHODS
  A retrospective review of the Cleft-Craniofacial Center database at Children's Hospital of Pittsburgh was performed from 2003 through 2007. Patients who underwent cranioplasties using demineralized bone matrix and resorbable mesh bilaminate were identified. Indications, defect size, quantity of demineralized bone matrix used, complications, follow-up, and computed tomographic scans were reviewed.
  
  
  RESULTS
  Eleven patients underwent 13 skull reconstructions using demineralized bone matrix and resorbable mesh bilaminate cranioplasty. Mean age was 3.6 years (range, 2.1 to 4.9 years); average defect size was 30.8 cm (range, 6.6 to 80.0 cm). Mean clinical follow-up was 29.3 months (range, 13.4 to 41.8 months). All patients had follow-up computed tomographic scans. The average time of follow-up scan was 18.7 months postoperatively (range, 6.9 to 32.6 months). Seven patients had immediate postoperative scans in addition to long-term follow-up scans, facilitating the calculation of a 98 percent average defect healing (range, 95 to 100 percent). All patients had clinically stable cranial reconstructions at follow-up.
  
  
  CONCLUSIONS
  When autogenous bone is not available, demineralized bone matrix and resorbable mesh bilaminate cranioplasty is an alternative method of calvarial reconstruction when used in a healthy site free of scarring or infection. This cranioplasty technique has provided consistent bony regeneration, with no donor-site morbidity.
authors.affiliation: Pittsburgh, Pa.; and Rochester, N.Y. From the Divisions of Pediatric Plastic Surgery and Pediatric Neurosurgery, Children's Hospital of Pittsburgh, University of Pittsburgh, and the Division of Plastic Surgery, Golisono Children's Hospital, University of Rochester.
authors.forename: Mimi T
authors.initials: MT
authors.lastname: Chao
authors.forename: Shao
authors.initials: S
authors.lastname: Jiang
authors.forename: Darren
authors.initials: D
authors.lastname: Smith
authors.forename: Gary E
authors.initials: GE
authors.lastname: DeCesare
authors.forename: Gregory M
authors.initials: GM
authors.lastname: Cooper
authors.forename: Ian F
authors.initials: IF
authors.lastname: Pollack
authors.forename: John
authors.initials: J
authors.lastname: Girotto
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Losee