title: [5-HT1A gene polymorphisms contributed to antidepressant response in major depression].
abstract: Variability in antidepressant response is due to genetic and environmental factors. Among genetic factors, the ones controlling for availability of the drug at the target site are interesting candidates. Rs6295C/G SNP in the 5-HT1A gene (HTR1A) has been found to affect the expression and function of HTR1A. In fact rs6295C/G is in strong linkage disequilibrium with other polymorphisms of HTR1A suggesting that those functional effects could be associated with polymorphisms other than or together with the synonymous rs6295C/G. In the present study we examined the possible association of a panel of markers in strong linkage disequilibrium of HTR1A with SSRI/SNRI response in 137 Japanese major depression subjects followed for 6 weeks. We observed a significant association of better response to antidepressant in rs10042486C/C (P < 0.0001), rs6295G/G (P < 0.0001) and rs1364043T/T (P = 0.018) genotype carriers, independently from clinical variables. Furthermore minor allele homozygous carriers in all these 3 SNPs were associated with treatment response by various assessments such as HAM-D score change over time (P = 0.001), week 2 (P < 0.0001), 4 (P = 0.007), and 6 (P = 0.048) as well as response rate (P = 0.0005) and remission rate (P = 0.004). We also pointed out the genotyping mis-definition of rs6295C/G in the previous four papers.
authors.affiliation: Department of Neuropsychiatry, Kansai Medical University, 10-15 Fumizonocho, Moriguchi 570-8506, Japan. katom@takii.kmu.ac.jp
authors.forename: Masaki
authors.initials: M
authors.lastname: Kato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Masaki
authors.initials: M
authors.lastname: Wakeno
authors.forename: Gaku
authors.initials: G
authors.lastname: Okugawa
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Takekita
authors.forename: Alessandro
authors.initials: A
authors.lastname: Serretti
authors.forename: Junichi
authors.initials: J
authors.lastname: Azuma
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kinoshita