Direct anti-selective catalytic asymmetric Mannich-type reactions of alpha-ketoanilides for the synthesis of gamma-amino amides and azetidine-2-amides.
Breaking with convention: A homodinuclear nickel complex derived from a biphenyldiamine-based Schiff base catalyzed an anti-selective Mannich-type reaction of alpha-ketoanilides (see scheme) to afford unique building blocks for the synthesis of azetidine-2-amides and alpha-hydroxy gamma-amino amides. This approach stands in contrast to conventional Mannich-type reactions for the synthesis of beta-amino carbonyl compounds. o-Ns = o-nitrobenzenesulfonyl.
Xu
Yingjie
Y
Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Lu
Gang
G
Matsunaga
Shigeki
S
Shibasaki
Masakatsu
M