Enantioselective conjugate addition of nitroalkanes to vinyl sulfone: an organocatalytic access to chiral amines.
Organocatalytic asymmetric conjugate addition of nitroalkanes to vinyl sulfone mediated by cinchona alkaloid-derived thiourea catalyst afforded the desired Michael product with good enantioselectivity. The described method, in combination with ready desulfonation, represents a novel approach to access alpha-alkylated chiral amines.
Zhu
Qiang
Q
Department of Chemistry & Medicinal Chemistry Program, Life Sciences Institute, National University of Singapore, 3 Science Drive 3, Republic of Singapore.
Lu
Yixin
Y