Pseudo-peptides derived from isomannide: inhibitors of serine proteases.
In this paper, we describe the synthesis of a novel class of pseudo-peptides derived from isomannide and several oxazolones as potential inhibitors of serine proteases as well as preliminary pharmacological assays for hepatitis C. Hepatitis C, dengue and West Nile fever are among the most important flaviviruses that share one important serine protease enzyme. Serine proteases belong to the most studied class of proteolytic enzymes and are a primary target in the drug development field. Several pseudo-peptides were obtained in good yields from the reaction of isomannide and oxazolones, and their anti-HCV potential using the HCV replicon-based assay was shown.
Barros
Thalita G
TG
Faculdade de Farmácia, Universidade Federal Fluminense, Rua Mario Viana 523, Santa Rosa, Niterói, RJ 24241000, Brazil.
Pinheiro
Sergio
S
Williamson
J S
JS
Tanuri
Amílcar
A
Gomes
M
M
Pereira
Helena S
HS
Brindeiro
R M
RM
Neto
José B A
JB
Antunes
O A C
OA
Muri
Estela M F
EM