Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.
A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.
Srivastava
Brijesh Kumar
BK
Department of Medicinal Chemistry, Zydus Research Centre, Sarkhej-Bavla N. H. 8A, Moraiya, Ahmedabad 382 210, India.
Soni
Rina
R
Patel
Jayendra Z
JZ
Joharapurkar
Amit
A
Sadhwani
Nisha
N
Kshirsagar
Samadhan
S
Mishra
Bhupendra
B
Takale
Vijay
V
Gupta
Sunil
S
Pandya
Purvi
P
Kapadnis
Prashant
P
Solanki
Manish
M
Patel
Harilal
H
Mitra
Prasenjit
P
Jain
Mukul R
MR
Patel
Pankaj R
PR