Biomarker discovery in asthma-related inflammation and remodeling.
Asthma is a complex inflammatory disease of airways. A network of reciprocal interactions between inflammatory cells, peptidic mediators, extracellular matrix components, and proteases is thought to be involved in the installation and maintenance of asthma-related airway inflammation and remodeling. To date, new proteic mediators displaying significant activity in the pathophysiology of asthma are still to be unveiled. The main objective of this study was to uncover potential target proteins by using surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS) on lung samples from mouse models of allergen-induced airway inflammation and remodeling. In this model, we pointed out several protein or peptide peaks that were preferentially expressed in diseased mice as compared to controls. We report the identification of different five proteins: found inflammatory zone 1 or RELM alpha (FIZZ-1), calcyclin (S100A6), clara cell secretory protein 10 (CC10), Ubiquitin, and Histone H4.
Calvo
Florence Quesada
FQ
Laboratory of Biology of Tumours and Development, University of Liège and Centre Hospitalier Universitaire (CHU-Liège), Belgium.
Fillet
Marianne
M
de Seny
Dominique
D
Meuwis
Marie-Alice
MA
Maree
Raphael
R
Crahay
Céline
C
Paulissen
Geneviève
G
Rocks
Natacha
N
Gueders
Maud
M
Wehenkel
Louis
L
Merville
Marie-Paule
MP
Louis
Renaud
R
Foidart
Jean-Michel
JM
Noël
Agnes
A
Cataldo
Didier
D