title: The impact of ertapenem use on the susceptibility of Pseudomonas aeruginosa to imipenem: a hospital case study.
abstract: We sought to evaluate the indirect impact of ertapenem use for the treatment of extended-spectrum beta-lactamase-producing Enterobacteriaceae infections in our hospital on the susceptibility of Pseudomonas aeruginosa to imipenem. The use of ertapenem was mandated for treatment of extended-spectrum beta-lactamase-producing Enterobacteriaceae infections in the absence of nonfermenting gram-negative bacilli for 1 year. The use of imipenem was restricted. Imipenem consumption decreased 64.5%. Ertapenem consumption was 42.57 defined daily doses per 1,000 patient-days. None of the 18 P. aeruginosa isolates recovered after ertapenem introduction were imipenem-resistant, compared with 4 of the 20 P. aeruginosa isolates recovered in the previous year.
authors.affiliation: Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil. allm.lima@uol.com.br
authors.forename: Ana Lucia L
authors.initials: AL
authors.lastname: Lima
authors.forename: Priscila R
authors.initials: PR
authors.lastname: Oliveira
authors.forename: Adriana P
authors.initials: AP
authors.lastname: Paula
authors.forename: Karine
authors.initials: K
authors.lastname: Dal-Paz
authors.forename: Flavia
authors.initials: F
authors.lastname: Rossi
authors.forename: Arnaldo V
authors.initials: AV
authors.lastname: Zumiotti