Anticipatory changes in regional cerebral hemodynamics: a new role for dopamine?
Recently, adaptively timed, anticipatory changes in hemodynamic responses, independent of neural activity, were described in primate primary visual cortex. Task-related properties of these responses point to a possible link between regional cerebral microcirculation and dopaminergic signaling. In this report, this link is elaborated on the basis of known physiological data and further experiments are proposed to test the possible role of dopamine in task-dependent, "on-demand" allocation of metabolic resources.
Tan
Can Ozan
CO
Department of Physical Medicine and Rehabilitation, Harvard Medical School, and Cardiovascular Research Laboratory, Spaulding Rehabilitation Hospital, Boston, Massachusetts 02114, USA. cotan@partners.org