title: The haemodynamic effects of adjunctive hormone therapy in potential heart donors: a prospective randomized double-blind factorially designed controlled trial.
abstract: OBJECTIVE
  The aim of this study was to assess the haemodynamic effects of tri-iodothyronine (T3) and methylprednisolone in potential heart donors.
  
  
  RESULTS
  In a prospective randomized double-blind trial, 80 potential cardiac donors were allocated to receive T3 (0.8 microg kg(-1) bolus; 0.113 microg kg(-1) h(-1) infusion) (n = 20), methylprednisolone (1000 mg bolus) (n = 19), both drugs (n = 20), or placebo (n = 21) following initial haemodynamic assessment. After hormone or placebo administration, cardiac output-guided optimization was initiated, using vasopressin as a pressor and weaning norepinephrine and inotropes. Treatment was administered for 5.9 +/- 1.3 h until retrieval or end-assessment. Cardiac index increased significantly (P < 0.001) but administration of T3 and methylprednisolone alone or in combination did not affect this change or the heart retrieval rate. Thirty-five per cent (14/40) of initially marginal or dysfunctional hearts were suitable for transplant at end-assessment. At end-assessment, 50% of donor hearts fulfilled criteria for transplant suitability.
  
  
  CONCLUSIONS
  Cardiac output-directed donor optimization improves donor circulatory status and has potential to increase the retrieval rate of donor hearts. Tri-iodothyronine and methylprednisolone therapy do not appear to acutely affect cardiovascular function or yield.
authors.affiliation: Department of Cardiothoracic Surgery, University Hospital Birmingham NHS foundation Trust, Birmingham and University of Birmingham, Edgbaston, Birmingham B15 2TH, UK.
authors.forename: Rajamiyer V
authors.initials: RV
authors.lastname: Venkateswaran
authors.forename: Richard P
authors.initials: RP
authors.lastname: Steeds
authors.forename: David W
authors.initials: DW
authors.lastname: Quinn
authors.forename: Peter
authors.initials: P
authors.lastname: Nightingale
authors.forename: Ian C
authors.initials: IC
authors.lastname: Wilson
authors.forename: Jorge G
authors.initials: JG
authors.lastname: Mascaro
authors.forename: Richard D
authors.initials: RD
authors.lastname: Thompson
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: Townend
authors.forename: Robert S
authors.initials: RS
authors.lastname: Bonser