Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II).
As our ongoing work, a series of peptidomimetic L-iso-glutamine derivatives derived from antineoplaston AS2-5 scaffold were prepared and their APN/CD13 and MMP-2 inhibitory activities were evaluated hereby. The results displayed that these compounds exhibited selective inhibition against APN as compared with MMP-2, with IC(50) values in micromole range. Compounds A1 and A2 showed comparable APN inhibitory activities than the positive control bestatin.
Li
Xun
X
School of Pharmaceutical Sciences, Shandong University, No. 44 WenhuaXi Road, Ji'nan, 250012, Shandong Province, PR China.
Wang
Yazhou
Y
Wu
Jifeng
J
Li
Yonggang
Y
Wang
Qiang
Q
Xu
Wenfang
W