title: Identification of a cannabinoid analog as a new type of designer drug in a herbal product.
abstract: A new type of designer drug, a cannabinoid analog (1), was found in a herbal product distributed on the illegal drug market in Japan in expectation of its narcotic effect. The structure of 1 was identified by LC-MS, GC-MS, high-resolution MS, and NMR analyses. Compound 1 showed a molecular weight of 332, and accurate mass measurement exhibited its elemental composition to be C(22)H(36)O(2). Together, the mass and NMR spectrometric data revealed that 1 was (1RS,3SR)-3-[4-(1,1-dimethyloctyl)-2-hydroxyphenyl]cyclohexan-1-ol, which was first synthesized in 1979 by a group at Pfizer Inc. and reported as a potent cannabinoid analog possessing cannabinoid receptor binding activity and analgesic activity in the 1990 s. This is the first report to identify a cannabinoid analog in an illegal drug.
authors.affiliation: National Institute of Health Sciences, Tokyo, Japan.
authors.forename: Nahoko
authors.initials: N
authors.lastname: Uchiyama
authors.forename: Ruri
authors.initials: R
authors.lastname: Kikura-Hanajiri
authors.forename: Nobuo
authors.initials: N
authors.lastname: Kawahara
authors.forename: Yuji
authors.initials: Y
authors.lastname: Haishima
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Goda