title: Voltammetric Behavior of o-Nitrophenol and Damage to DNA.
abstract: The electrochemical behavior of o-nitrophenol was studied in detail with a glassy carbon electrode (GCE). The dependence of peak potential on pH indicated that equivalent electrons and protons were involved in the process of o-nitrophenol reduction. The interaction of o-nitrophenol with calf thymus DNA was investigated by adding DNA to the o-nitrophenol solution and by immobilizing DNA on GCE, respectively. The peak current decrement and peak potential shift in presence of DNA indicated that o-nitrophenol could interact with DNA. The result was demonstrated that the in situ DNA damage was detected by differential pulse voltammetry after the o-nitrophenol was electrochemically reduced.
authors.affiliation: College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China.
authors.forename: Da-Peng
authors.initials: DP
authors.lastname: Zhang
authors.affiliation: College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China.
authors.forename: Wei-Li
authors.initials: WL
authors.lastname: Wu
authors.affiliation: College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China.
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Long
authors.affiliation: College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China.
authors.forename: Yun-Chun
authors.initials: YC
authors.lastname: Liu
authors.affiliation: College of Chemistry and Materials Science, Anhui Key Laboratory of Chemo-Biosensing, Anhui Normal University, Wuhu 241000, P.R. China.
authors.forename: Zhou-Sheng
authors.initials: ZS
authors.lastname: Yang