title: Biomarker discovery in asthma-related inflammation and remodeling.
abstract: Asthma is a complex inflammatory disease of airways. A network of reciprocal interactions between inflammatory cells, peptidic mediators, extracellular matrix components, and proteases is thought to be involved in the installation and maintenance of asthma-related airway inflammation and remodeling. To date, new proteic mediators displaying significant activity in the pathophysiology of asthma are still to be unveiled. The main objective of this study was to uncover potential target proteins by using surface-enhanced laser desorption/ionization-time of flight-mass spectrometry (SELDI-TOF-MS) on lung samples from mouse models of allergen-induced airway inflammation and remodeling. In this model, we pointed out several protein or peptide peaks that were preferentially expressed in diseased mice as compared to controls. We report the identification of different five proteins: found inflammatory zone 1 or RELM alpha (FIZZ-1), calcyclin (S100A6), clara cell secretory protein 10 (CC10), Ubiquitin, and Histone H4.
authors.affiliation: Laboratory of Biology of Tumours and Development, University of Liège and Centre Hospitalier Universitaire (CHU-Liège), Belgium.
authors.forename: Florence Quesada
authors.initials: FQ
authors.lastname: Calvo
authors.forename: Marianne
authors.initials: M
authors.lastname: Fillet
authors.forename: Dominique
authors.initials: D
authors.lastname: de Seny
authors.forename: Marie-Alice
authors.initials: MA
authors.lastname: Meuwis
authors.forename: Raphael
authors.initials: R
authors.lastname: Maree
authors.forename: Céline
authors.initials: C
authors.lastname: Crahay
authors.forename: Geneviève
authors.initials: G
authors.lastname: Paulissen
authors.forename: Natacha
authors.initials: N
authors.lastname: Rocks
authors.forename: Maud
authors.initials: M
authors.lastname: Gueders
authors.forename: Louis
authors.initials: L
authors.lastname: Wehenkel
authors.forename: Marie-Paule
authors.initials: MP
authors.lastname: Merville
authors.forename: Renaud
authors.initials: R
authors.lastname: Louis
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Agnes
authors.initials: A
authors.lastname: Noël
authors.forename: Didier
authors.initials: D
authors.lastname: Cataldo