title: [Histology after tonsillectomy?].
abstract: BACKGROUND
  The necessity to rule out clinically occult malignancies by routine histological examination of all tonsillectomy specimens is a controversial topic.
  
  
  METHODS
  Clinical and histological findings of all patients who underwent tonsillectomy at the University of Bonn, Germany from January 2002 to March 2007 were retrospectively reviewed. A meta-analysis of PubMed literature regarding the histological results of tonsil specimens was performed. The incidence of clinically occult tonsil malignancy was recorded and potential risk factors for malignancy were analyzed. A cost-effectiveness ratio of microscopic analysis of all specimens was also performed.
  
  
  RESULTS
  Clinically occult tonsil malignancies were detected in 2 out of the 1,523 patients (0.13%) in this study. In the meta-analysis of 24 studies (61,550 patients) 6 cases of clinically occult tonsil malignancies (0.01%) were identified. Statistically 7,694 tonsils have to be histologically examined to detect 1 case of occult malignancy which corresponds to an average cost per case of 385,000 EUR.
  
  
  CONCLUSIONS
  Considering economical aspects we recommend that histological examination should be performed when the following risk factors are present: a history of cancer, tonsil firmness or lesions, tonsillar asymmetry, swelling of neck lymph nodes, constitutional symptoms, anamnestic unilateral symptoms and prior peritonsillar abscess.
authors.affiliation: Klinik und Poliklinik für Hals-Nasen-Ohren-Heilkunde/Chirurgie, Rheinische Friedrich-Wilhelms-Universität, Sigmund-Freud-Strasse 25, 53127 Bonn. andreasschroeck@web.de
authors.forename: A
authors.initials: A
authors.lastname: Schrock
authors.forename: M
authors.initials: M
authors.lastname: Jakob
authors.forename: T
authors.initials: T
authors.lastname: Send
authors.forename: L
authors.initials: L
authors.lastname: Heukamp
authors.forename: M
authors.initials: M
authors.lastname: Bucheler
authors.forename: F
authors.initials: F
authors.lastname: Bootz