title: Design and biological evaluation of novel, balanced dual PPARalpha/gamma agonists.
abstract: An X-ray-guided design approach led to the identification of a novel, balanced class of alpha-ethoxy-phenylpropionic acid-derived dual PPARalpha/gamma agonists. The series shows a wide range of PPARalpha/gamma ratios within a rather narrow structural space. Advanced compounds possess favorable physicochemical and pharmacokinetic profiles and show a high efficacy in T2D and dyslipidemia animal models.
authors.affiliation: Pharma Research, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland. uwe.grether@roche.com
authors.forename: Uwe
authors.initials: U
authors.lastname: Grether
authors.forename: Agnes
authors.initials: A
authors.lastname: Bénardeau
authors.forename: Jörg
authors.initials: J
authors.lastname: Benz
authors.forename: Alfred
authors.initials: A
authors.lastname: Binggeli
authors.forename: Denise
authors.initials: D
authors.lastname: Blum
authors.forename: Hans
authors.initials: H
authors.lastname: Hilpert
authors.forename: Bernd
authors.initials: B
authors.lastname: Kuhn
authors.forename: Hans Peter
authors.initials: HP
authors.lastname: Märki
authors.forename: Markus
authors.initials: M
authors.lastname: Meyer
authors.forename: Peter
authors.initials: P
authors.lastname: Mohr
authors.forename: Kurt
authors.initials: K
authors.lastname: Püntener
authors.forename: Susanne
authors.initials: S
authors.lastname: Raab
authors.forename: Armin
authors.initials: A
authors.lastname: Ruf
authors.forename: Daniel
authors.initials: D
authors.lastname: Schlatter