title: Regulation of adiponectin receptor 2 expression via PPAR-alpha in NIT-1 cells.
abstract: Adiponectin receptors mediate the antidiabetic effects of adiponectin. Although suggested to be mainly expressed in muscle, liver, and adipocyte cells, the expression of adiponectin receptors in beta cells is unclear. Given the primary involvement of this cell type in diabetes mellitus, we presently examined the expression level of adiponectin receptor 2 (AdiR2) in beta cells. Expression was significantly increased under acute hyperlipidemic conditions but impaired under chronic conditions. The impaired AdiR2 expression may play a role in worsened beta cell function. Clofibrate, an agonist of peroxisome proliferator-activated receptor-alpha (PPAR-alpha) delayed the palmitate-induced impairment of AdiR2 expression and PPAR-alpha; this delay was abolished by PPAR-alpha targeted small interfering RNA. The results suggest that AdiR2 expression is regulated by palmitate via PPAR-alpha.
authors.affiliation: Samsung Biomedical Institute, Seoul, Korea.
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Jung
authors.forename: Myung Won
authors.initials: MW
authors.lastname: Lee
authors.forename: Yong Jik
authors.initials: YJ
authors.lastname: Lee
authors.forename: Seon Mee
authors.initials: SM
authors.lastname: Kim
authors.forename: Kyoung Tae
authors.initials: KT
authors.lastname: Lee
authors.forename: Wan Kyunn
authors.initials: WK
authors.lastname: Whang
authors.forename: Hwan Ju
authors.initials: HJ
authors.lastname: Cheon
authors.forename: Yeon Taek
authors.initials: YT
authors.lastname: Jeong
authors.forename: Kun Wook
authors.initials: KW
authors.lastname: Chung
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Cho
authors.forename: Do Hoon
authors.initials: DH
authors.lastname: Kim
authors.forename: Tae Woo
authors.initials: TW
authors.lastname: Jung