title: Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
abstract: Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.
authors.affiliation: Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
authors.forename: Kate
authors.initials: K
authors.lastname: Schroder
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Muruve
authors.forename: Jürg
authors.initials: J
authors.lastname: Tschopp