title: Association between immunohistochemical markers of myocardial damage and apoptosis.
abstract: Cardiac disease is the most common cause of sudden unexpected death. In forensic practice there is a need for more sensitive diagnostic methods for the post-mortem diagnosis of myocardial damage. The aim of this study was to evaluate the association of the markers routinely used for the diagnosis of acute cardiac necrosis (myosin, troponin I and myoglobin with) and the presence of apoptosis, in order to evaluate the utility of apoptosis for use as a diagnostic marker during the early stage of acute myocardial damage. A positive correlation was observed between neovascularization and signs of recent and past necrosis. Not relationship was observed between age at death, post-mortem interval and apoptosis. No statistical association was found between the expression of acute cardiac necrosis markers and the presence of apoptosis.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, University of Zaragoza, C/Domingo Miral, S/N, 50009 Zaragoza, Spain. ycasalod@unizar.es
authors.forename: Y
authors.initials: Y
authors.lastname: Casalod
authors.forename: R
authors.initials: R
authors.lastname: Alegret
authors.forename: B
authors.initials: B
authors.lastname: Martinez-Jarreta
authors.forename: M
authors.initials: M
authors.lastname: Gomez Zapata
authors.forename: A
authors.initials: A
authors.lastname: Luna