Novel regenerative strategies to enhance periodontal therapy outcome.
BACKGROUND
Chronic periodontitis is a widely prevalent inflammatory condition of the supporting tissues of the teeth and is characterized by loss of teeth with an associated risk of systemic complications. Regenerative therapies such as guided tissue and bone regeneration form an important armamentarium in periodontics with a high degree of outcome predictability in certain ideal clinical scenarios.


OBJECTIVE
This review elaborates novel tissue regenerative treatment modalities based on sound understanding of developmental biology, tissue engineering, inflammation and wound healing. We focus on the role of biological mediators such as growth factors, gene-based therapy, cell therapy and pro-resolution lipid mediators in the regeneration of lost bone or periodontium.


CONCLUSIONS
These therapies have the potential to regenerate both periodontium and bone, aiding in the treatment of even clinically challenging cases.
Elangovan
Satheesh
S
Harvard School of Dental Medicine, Division of Periodontology, Department of Oral Medicine, Infection and Immunity, 188 Longwood Avenue, Boston, MA-02115, USA. Satheesh_Elangovan@hsdm.harvard.edu
Srinivasan
Sreedevi
S
Ayilavarapu
Srinivas
S