A model study for the concise construction of the oxapentacyclic core of cortistatins through intramolecular Diels-Alder and oxidative dearomatization-cyclization reactions.
A unified strategy towards the facile construction of the [6.7.6.5] oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA) and oxidative dearomatization-cyclization reactions as key steps.
Liu
Lianzhu
L
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen 518055, China.
Gao
Yingxiang
Y
Che
Chao
C
Wu
Na
N
Wang
David Zhigang
DZ
Li
Chuang-Chuang
CC
Yang
Zhen
Z