title: Treatment of multilesion coronary artery disease with simultaneous drug-eluting and bare-metal stent implantation: clinical follow up and angiographic mid-term results.
abstract: OBJECTIVE
  We sought to evaluate clinical and angiographic outcomes of percutaneous coronary intervention (PCI) in patients receiving both bare-metal stents (BMS) and drug-eluting stents (DES).
  
  
  BACKGROUND
  Few data are available about the safety and efficacy of the practice namely called "hybrid PCI".
  
  
  METHODS
  One hundred and eighty-six patients, 502 de novo lesions, received during PCI both BMS (n = 266) and DES (316), with a mean of 3.1 +/- 1.2 stents/patient. Cumulative major adverse cardiac events were analyzed at 24 +/- 22 months.
  
  
  RESULTS
  Clinical follow up was carried out in 100% of eligible patients. Angiographic follow up at 8.6 +/- 4.4 months was achieved in 70.4% of patients, 71.6% of stents and 72.5% of lesions. Binary restenosis was 12.9% vs. 20.6% (p = 0.034) in DES vs. BMS, respectively; late loss was significantly higher in BMS than in DES (0.67 +/- 0.73 vs. 0.35 +/- 0.71 mm; p < 0.001). DES showed less lumen loss and binary restenosis rates than BMS in B2/C lesions (p < 0.001 and 0.007, respectively), while any significant difference was detected in A/B1 lesions (p = 0.27 and 0.76, respectively).
  
  
  CONCLUSIONS
  The simultaneous use of DES and BMS is safe and provides similar results for the 2 stents only in simple lesions. In complex lesions, BMS offer restenosis and a target lesion revascularization rates significantly higher than with DES.
authors.affiliation: Department of Cardiology, Ferrarotto Hospital, University of Catania, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Mirabella
authors.forename: Bruno
authors.initials: B
authors.lastname: Francaviglia
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Di Salvo
authors.forename: Alfredo Ruggero
authors.initials: AR
authors.lastname: Galassi
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ussia
authors.forename: Piera
authors.initials: P
authors.lastname: Capranzano
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino