title: 99mTc Nanocoll: a radiopharmaceutical for sentinel node localisation in breast cancer--in vitro and in vivo results.
abstract: This study evaluated labelling efficiency and radiochemical purity of (99m)Tc colloid albumin to identify an optimal labelling protocol for sentinel node detection. Results indicate that a 72 h eluate is not recommended for high specific labelling of (99m)Tc colloid albumin. Ex vivo, significantly higher count rates were reached using a 2h eluate in vacuum or nitrogen. Labelling 26 MBq/microg (99m)Tc colloid albumin with a 2 h eluate under nitrogen is recommended because of the ease of labelling.
authors.affiliation: Department of Nuclear Medicine, West-Fries Hospital Hoorn, The Netherlands. g.m.m.gommans@mca.nl
authors.forename: G M M
authors.initials: GM
authors.lastname: Gommans
authors.forename: E
authors.initials: E
authors.lastname: Gommans
authors.forename: F M
authors.initials: FM
authors.lastname: van der Zant
authors.forename: G J J
authors.initials: GJ
authors.lastname: Teule
authors.forename: T G
authors.initials: TG
authors.lastname: van der Schors
authors.forename: J W D
authors.initials: JW
authors.lastname: de Waard