title: Hair growth stimulator property of thienyl substituted pyrazole carboxamide derivatives as a CB1 receptor antagonist with in vivo antiobesity effect.
abstract: A few thienyl substituted pyrazole derivatives were synthesized to aid in the characterization of the cannabinoid receptor antagonist and also to serve as potentially useful antiobesity agent. Structural requirements for selective CB1 receptor antagonistic activity of 5-thienyl pyrazole derivatives included the structural similarity with potent, specific antagonist rimonabant 1. Compound 3 has been identified as a hair growth stimulator and an antiobesity agent in animal models.
authors.affiliation: Department of Medicinal Chemistry, Zydus Research Centre, Sarkhej-Bavla N. H. 8A, Moraiya, Ahmedabad 382 210, India.
authors.forename: Brijesh Kumar
authors.initials: BK
authors.lastname: Srivastava
authors.forename: Rina
authors.initials: R
authors.lastname: Soni
authors.forename: Jayendra Z
authors.initials: JZ
authors.lastname: Patel
authors.forename: Amit
authors.initials: A
authors.lastname: Joharapurkar
authors.forename: Nisha
authors.initials: N
authors.lastname: Sadhwani
authors.forename: Samadhan
authors.initials: S
authors.lastname: Kshirsagar
authors.forename: Bhupendra
authors.initials: B
authors.lastname: Mishra
authors.forename: Vijay
authors.initials: V
authors.lastname: Takale
authors.forename: Sunil
authors.initials: S
authors.lastname: Gupta
authors.forename: Purvi
authors.initials: P
authors.lastname: Pandya
authors.forename: Prashant
authors.initials: P
authors.lastname: Kapadnis
authors.forename: Manish
authors.initials: M
authors.lastname: Solanki
authors.forename: Harilal
authors.initials: H
authors.lastname: Patel
authors.forename: Prasenjit
authors.initials: P
authors.lastname: Mitra
authors.forename: Mukul R
authors.initials: MR
authors.lastname: Jain
authors.forename: Pankaj R
authors.initials: PR
authors.lastname: Patel