Concentrations of voriconazole in healthy and inflamed lung in rats.
By utilizing the microdialysis technique, we investigated the pharmacokinetic profile of voriconazole in the interstitium of the lungs and skeletal muscle tissue of rats after a single intravenous dose under healthy and inflammatory conditions. As expected, voriconazole penetrated excellently into the interstitium of tissues, and its levels were descriptively almost identical to free concentration-versus-time profiles in plasma.
Joukhadar
Christian
C
Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. christian.joukhadar@jp-medical-research.com
Thallinger
Christiane
C
Pöppl
Wolfgang
W
Kovar
Florian
F
Konz
Karl H
KH
Joukhadar
Samir M
SM
Traunmüller
Friederike
F