title: Asymmetric total synthesis of B-ring modified (-)-epicatechin gallate analogues and their modulation of beta-lactam resistance in Staphylococcus aureus.
abstract: Two enantiomerically pure B-ring modified analogues of (-)-epicatechin gallate were synthesised and their modulation of beta-lactam resistance using three strains of methicillin resistant Staphylococcus aureus (BB 568, EMRSA-15 and EMRSA-16) evaluated. Sub-inhibitory concentrations (12.5 and 25 mg/L) of the two analogues fully sensitised each of the three MRSA strains to oxacillin, reducing the MIC to less than 0.5 mg/L, identical to levels achieved with ECg. Lower concentrations demonstrated that the position and degree of hydroxylation of the B-ring is important for activity.
authors.affiliation: School of Chemistry, University of Nottingham, Nottingham, NG7 2RD, UK.
authors.forename: James C
authors.initials: JC
authors.lastname: Anderson
authors.forename: Catherine
authors.initials: C
authors.lastname: Headley
authors.forename: Paul D
authors.initials: PD
authors.lastname: Stapleton
authors.forename: Peter W
authors.initials: PW
authors.lastname: Taylor