Myelodysplasia and acute leukemia as late complications of marrow failure: future prospects for leukemia prevention.
Patients who have acquired and inherited bone marrow failure syndromes are at risk for the development of clonal neoplasms including acute myeloid leukemia, myelodysplastic syndrome, and paroxysmal nocturnal hemoglobinuria. This article reviews the evidence supporting a model of clonal selection, a paradigm that provides a reasonable expectation that these often fatal complications might be prevented in the future.
Bagby
Grover C
GC
Department of Molecular and Medical Genetics, Oregon Health and Sciences University, Portland, OR, USA. grover@ohsu.edu
Meyers
Gabrielle
G