title: First detection of a novel HIV Type 1 CRF01_AE/07_BC recombinant among an epidemiologically linked cohort of IDUs in Jiangsu, China.
abstract: Our recent study showed that almost equal proportions of B, CRFs_BC, and CRF01_AE were circulating among MSM in Jiangsu, suggesting that there is a very high likelihood of generating new intersubtypes/CRFs recombinants. Here, we report an epidemiologically linked cohort including 22 HIV-1-positive IDUs in Jiangsu. Fifteen blood samples were collected to investigate HIV-1 subtype characterization. The analyses of gag-RT regions showed that 14 of these samples belonged to CRF07_BC. Importantly, we detected, for the first time, a novel second-generation HIV-1 recombinant (07JSNJ001) between CRF01_AE and CRF07_BC. The analyses of the near full-length genomic sequence of 07JSNJ001 (GenBank accession number FJ238521) showed that 07JSNJ001 is composed of at least 10 interlaced CRF07_BC and CRF01_AE segments, quite distinct from any previously identified CRF and URF around the world. The detection of the CRF01_AE/CRF07_BC recombinant may be a harbinger of more new intersubtypes/CRFs recombinants occurring in Jiangsu Province.
authors.affiliation: Jiangsu Center for Disease Control and Prevention, Nanjing, Jiangsu 210009, China.
authors.forename: Hongxiong
authors.initials: H
authors.lastname: Guo
authors.forename: Dongmei
authors.initials: D
authors.lastname: Guo
authors.forename: Ji-Fu
authors.initials: JF
authors.lastname: Wei
authors.forename: Haitao
authors.initials: H
authors.lastname: Yang
authors.forename: Xiping
authors.initials: X
authors.lastname: Huan
authors.forename: Stephen Kwok-Wing
authors.initials: SK
authors.lastname: Tsui
authors.forename: Rongge
authors.initials: R
authors.lastname: Yang
authors.forename: Chiyu
authors.initials: C
authors.lastname: Zhang