title: Aortic root morphology in patients undergoing percutaneous aortic valve replacement: evidence of aortic root remodeling.
abstract: OBJECTIVE
  Percutaneous aortic valve replacement is an emerging therapy for selected patients with severe aortic stenosis. Preoperative imaging of the aortic root facilitates sizing and deployment of the percutaneous aortic valve replacement device. We compared morphologic characteristics of the aortic root in patients with aortic stenosis versus elderly gender-matched controls using multidetector computed tomography.
  
  
  METHODS
  Twenty-five consecutive subjects with severe calcific aortic stenosis referred for percutaneous aortic valve replacement and 25 elderly gender-matched controls were scanned on a Siemens Definition Dual Source (Siemens Medical, Forchheim, Germany) multidetector computed tomography scanner. Distances from the valve annulus to the coronary artery ostia and sinotubular junction, dimensions of the aortic root, and characteristics of the valve cusps were determined.
  
  
  RESULTS
  Subjects with aortic stenosis had reduced distance from the aortic valve annulus to the inferior margins of the left and right coronary artery ostium and sinotubular junction compared with controls. There were no significant differences in cross-sectional dimensions of the aortic root.
  
  
  CONCLUSIONS
  The distance from the aortic valve annulus to the coronary artery ostia and sinotubular junction is reduced in patients with aortic stenosis compared with controls. This finding suggests that longitudinal remodeling of the aortic root occurs in calcific aortic stenosis and has implications for the design and deployment of percutaneous aortic valve replacement devices.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
authors.forename: Mateen
authors.initials: M
authors.lastname: Akhtar
authors.forename: E Murat
authors.initials: EM
authors.lastname: Tuzcu
authors.forename: Samir R
authors.initials: SR
authors.lastname: Kapadia
authors.forename: Lars G
authors.initials: LG
authors.lastname: Svensson
authors.forename: Roy K
authors.initials: RK
authors.lastname: Greenberg
authors.forename: Eric E
authors.initials: EE
authors.lastname: Roselli
authors.forename: Sandra
authors.initials: S
authors.lastname: Halliburton
authors.forename: Vikram
authors.initials: V
authors.lastname: Kurra
authors.forename: Paul
authors.initials: P
authors.lastname: Schoenhagen
authors.forename: Srikanth
authors.initials: S
authors.lastname: Sola