title: Insulin therapy and glycemic control in hospitalized patients with diabetes during enteral nutrition therapy: a randomized controlled clinical trial.
abstract: OBJECTIVE
  To compare two subcutaneous insulin strategies for glycemic management of hyperglycemia in non-critically ill hospitalized patients with diabetes during enteral nutrition therapy (ENT).
  
  
  METHODS
  Fifty inpatients were prospectively randomized to receive sliding-scale regular insulin (SSRI) alone (n = 25) or in combination with insulin glargine (n = 25). NPH insulin was added for persistent hyperglycemia in the SSRI group (glucose >10 mmol/l).
  
  
  RESULTS
  Glycemic control was similar in the SSRI and glargine groups (mean +/- SD study glucose 8.9 +/- 1.6 vs. 9.2 +/- 1.6 mmol/l, respectively; P = 0.71). NPH insulin was added in 48% of the SSRI group subjects. There were no group differences in frequency of hypoglycemia (1.3 +/- 4.1 vs. 1.1 +/- 1.8%; P = 0.35), total adverse events, or length of stay.
  
  
  CONCLUSIONS
  Both insulin strategies (SSRI with the addition of NPH for persistent hyperglycemia and glargine) demonstrated similar efficacy and safety in non-critically ill hospitalized patients with type 2 diabetes during ENT.
authors.affiliation: Department of Medicine, Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. korytkowski@dom.pitt.edu
authors.forename: Mary T
authors.initials: MT
authors.lastname: Korytkowski
authors.forename: Rose J
authors.initials: RJ
authors.lastname: Salata
authors.forename: Glory L
authors.initials: GL
authors.lastname: Koerbel
authors.forename: Faith
authors.initials: F
authors.lastname: Selzer
authors.forename: Esra
authors.initials: E
authors.lastname: Karslioglu
authors.forename: Almoatazbellah M
authors.initials: AM
authors.lastname: Idriss
authors.forename: Kenneth K W
authors.initials: KK
authors.lastname: Lee
authors.forename: A James
authors.initials: AJ
authors.lastname: Moser
authors.forename: Frederico G S
authors.initials: FG
authors.lastname: Toledo