[Chronic kidney disease (CKD) and bone. Regulation of calcium and phosphate metabolism by FGF23/Klotho].
Fibroblast growth factor 23 (FGF23) is a hormone which is produced by osteocytes and lowers serum phosphate and 1,25-dihydroxyvitamin D levels by binding to Klotho-FGF receptor complex in kidney. It has been shown that excess actions of FGF23 cause hypophosphatemic diseases white deficient actions of FGF23 result in hyperphosphatemic disorders. It should be tested in the future whether development of methods to modify FGF23 actions leads to novel therapeutic approaches for bone and mineral disorders.
Fukumoto
Seiji
S
Division of Nephrology & Endocrinology, Department of Medicine, University of Tokyo Hospital.