Studies of the photooxidant properties of antibacterial fluoroquinolones and their naphthalene derivatives.
We synthesized and determined the production of reactive oxygen species (ROS) as 1O2, *-O2, *OH, H2O2 during the photolysis with UV-A light of three antibacterial quinolones and their naphthyl ester derivatives. Singlet oxygen and ROS dose-dependant generation from norfloxacin (1), enoxacin (2), ciprofloxacin (3) and their respective naphthyl ester derivatives 4-6 were detecting in cell-free systems by the histidine assay and by luminol-enhanced chemiluminescence (LCL). Both the electronic absorption and emission spectra were quantified and their photostability determined. The antibacterial activity in darkness and under irradiation of compounds 4, 5 and 6 was tested on E. coli and compared with their parent drugs.
Vargas
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F
Laboratorio de Fotoquímica, Centro de Química, Instituto Venezolano de Investigaciones Científicas I.V.I.C., Carretera Panamericana Klm. 11, Apartado 20632, Caracas 1020-A, Venezuela. fvargas@ivic.ve
Zoltan
T
T
Ramirez
A H
AH
Cordero
T
T
Chavez
V
V
Izzo
C
C
López
V
V
Cárdenas
Y M
YM
Fernández
A
A
Hincapie
L
L
Fuentes
A
A