Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.
Kuduk
Scott D
SD
Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA.
Di Marco
Christina N
CN
Chang
Ronald K
RK
Dipardo
Robert M
RM
Cook
Sean P
SP
Cato
Matthew J
MJ
Jovanovska
Aneta
A
Urban
Mark O
MO
Leitl
Michael
M
Spencer
Robert H
RH
Kane
Stefanie A
SA
Bilodeau
Mark T
MT
Hartman
George D
GD
Bock
Mark G
MG