title: Wheat allergy.
abstract: OBJECTIVE
  This review describes the diverse clinical manifestations of IgE-mediated allergy to ingested wheat and summarizes recent advances in characterization of clinically significant allergens and diagnostic workup.
  
  
  RESULTS
  Recent population-based studies have shown the prevalence of wheat allergy and sensitization more precisely than past studies among small populations and in hospital settings. Intensive research has demonstrated the diverse profile of both water/salt-soluble and insoluble allergens involved in clinical types of wheat allergies determined depending on the patient age, the sensitization route, and the protein state during the exposure. Consequently, some new allergens, including nonspecific lipid transfer protein (Tri a 14), have been identified. For diagnosis, the role of water/salt-insoluble gliadins, particularly omega-5 gliadin, a major allergen of wheat-dependent, exercise-induced anaphylaxis, was assessed as compared with the results of oral challenges. The mechanisms of eliciting anaphylactic symptoms by exercise in wheat-dependent, exercise-induced anaphylaxis were speculated upon; one is the allergenicity strengthened by activated tissue transglutaminase and another is the increased absorption of allergens through the gastrointestinal tract.
  
  
  CONCLUSIONS
  Findings of the recent studies show potential for more precise diagnosis in each clinical type of wheat allergies.
authors.affiliation: Department of Dermatology, Yokohama City University Hospital, Yokohama, Japan. ninomata@med.yokohama-cu.ac.jp
authors.forename: Naoko
authors.initials: N
authors.lastname: Inomata