title: Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial.
abstract: This study aimed to evaluate the efficacy of the systemic drugs thalidomide, dapsone, colchicine, and pentoxifylline in the treatment of severe manifestations of RAS.
  
  
  
  An open, 4-year clinical trial was carried out for 21 consecutive patients with severe RAS. Initially, patients were given a 2-week course of prednisone to bring them to a baseline status. Simultaneously, one of the four test drugs was assigned to each patient to be taken for a period of 6 months. During the course of the trial, patients were switched to one of the other three drugs whenever side effects or a lack of satisfactory results occurred, and the 6-month limit of the treatment was then reset.
  
  
  
  The most efficient and best-tolerated drug was thalidomide, which was administered to a total of eight patients and resulted in complete remission in seven (87.5%). Dapsone was prescribed for a total of nine patients, of whom eight (89%) showed improvement in their symptoms, while five showed complete remission. Colchicine was administered to a total of ten patients, with benefits observed in nine (90%), of whom four showed complete remission. Pentoxyfilline was administered to a total of five patients, with benefits observed in three (60%), of whom one patient showed complete remission.
  
  
  
  The therapeutic methods used in this trial provided significant symptom relief. Patients experienced relapses of the lesions; however, this occurred after withdrawal of their medication during the follow-up period.
authors.affiliation: Department of Stomatology, School of Dentistry, University of São Paulo - São Paulo/SP, Brazil.
authors.forename: Maria Angela Martins
authors.initials: MA
authors.lastname: Mimura
authors.forename: Silvio Kenji
authors.initials: SK
authors.lastname: Hirota
authors.forename: Norberto Nobuo
authors.initials: NN
authors.lastname: Sugaya
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Sanches
authors.forename: Dante Antonio
authors.initials: DA
authors.lastname: Migliari