PD-1 on dendritic cells impedes innate immunity against bacterial infection.
Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1-deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-alpha. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.
Yao
Sheng
S
Department of Oncology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Wang
Shengdian
S
Zhu
Yuwen
Y
Luo
Liqun
L
Zhu
Gefeng
G
Flies
Sarah
S
Xu
Haiying
H
Ruff
William
W
Broadwater
Megan
M
Choi
In-Hak
IH
Tamada
Koji
K
Chen
Lieping
L