title: New Rev-export inhibitor from Alpinia galanga and structure-activity relationship.
abstract: Bioassay-guided separation by use of the fission yeast expressing NES of Rev, an HIV-1 viral regulatory protein, disclosed 1'-acetoxychavicol acetate (ACA, 1) as a new inhibitor for nuclear export of Rev from the roots of Alpinia galanga. Both analysis for mechanism of action with biotinylated probe (2) and several synthesized analogs established crucial portions in 1 for Rev-export inhibitory activity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
authors.forename: Satoru
authors.initials: S
authors.lastname: Tamura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Shiomi
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kaneko
authors.forename: Ying
authors.initials: Y
authors.lastname: Ye
authors.forename: Minoru
authors.initials: M
authors.lastname: Yoshida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: Tominori
authors.initials: T
authors.lastname: Kimura
authors.forename: Motomasa
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Nobutoshi
authors.initials: N
authors.lastname: Murakami