Efficacy of concurrent chemoradiotherapy for T1 and T2 laryngeal squamous cell carcinoma regarding organ preservation.
BACKGROUND
Although the survival rate of early-stage laryngeal squamous cell carcinoma (SCC) patients treated by radiotherapy (RT) is sufficient, the larynx preservation rate is unsatisfactory. To improve the larynx preservation rate, such patients have been treated by RT with chemotherapeutic agents.


METHODS
RT with or without uracil-tegafur (UFT) was performed for T1 cases, and UFT and carboplatin for T2 cases.


RESULTS
In T1 cases, 30 patients received RT and 16 patients received concurrent chemoradiotherapy (CCRT). In T2 cases, 28 patients received RT and 45 patients received CCRT. There were no significant differences in the response and survival rates between the treatment methods both in T1 and T2 cases. The 5-year larynx preservation survival rate was improved significantly by CCRT in T2 cases (66.7% vs. 93.3%; p < 0.01).


CONCLUSIONS
CCRT for early-stage laryngeal SCC patients was efficacious to improve the larynx preservation survival rate.
Nishimura
Goshi
G
Department of Biology and Function in the Head and Neck, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan. gnishimu@yokohama-cu.ac.jp
Tsukuda
Mamoru
M
Mikami
Yasukazu
Y
Matsuda
Hideki
H
Horiuchi
Choichi
C
Taguchi
Takahide
T
Takahashi
Masahiro
M
Kawakami
Mariko
M
Watanabe
Makiko
M
Niho
Tatsuo
T
Abo
Hiroaki
H
Yamomoto
Sayaka
S