Bidirectional metalation of hydrobenzoin: direct access to new chiral ligands and auxiliaries.
A bidirectional ortho metalation of the readily available chiral diol hydrobenzoin has been developed that provides direct access to new ortho-functionalized hydrobenzoin derivatives. This one-pot procedure should broaden the utility of hydrobenzoin as an auxiliary and ligand in asymmetric synthesis.
Cho
Inhee
I
Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada V5A 1S6.
Meimetis
Labros
L
Britton
Robert
R