title: New Labdane diterpenes as intestinal alpha-glucosidase inhibitor from antihyperglycemic extract of Hedychium spicatum (Ham. Ex Smith) rhizomes.
abstract: Phytochemical investigation of antihyperglycemic extract of rhizomes of Hedychium spicatum led to the isolation of two new labdane type diterpenes 2, 3 along with seven known compounds (1, 4-9). Their structures were established on the basis of NMR (1D and 2D) and mass spectroscopic analysis. The new compound 2 displayed strong intestinal alpha-glucosidase inhibitory activity. Other compounds also displayed varying degree of intestinal alpha-glucosidase inhibitory potential.
authors.affiliation: Natural Products Laboratory, Indian Institute of Chemical Technology, Uppal Road, Hyderabad 500 607, India.
authors.forename: P
authors.initials: P
authors.lastname: Prabhakar Reddy
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Tiwari
authors.forename: R
authors.initials: R
authors.lastname: Ranga Rao
authors.forename: K
authors.initials: K
authors.lastname: Madhusudhana
authors.forename: V
authors.initials: V
authors.lastname: Rama Subba Rao
authors.forename: Amtul Z
authors.initials: AZ
authors.lastname: Ali
authors.forename: K
authors.initials: K
authors.lastname: Suresh Babu
authors.forename: J
authors.initials: J
authors.lastname: Madhusudana Rao