title: Sequential phosphine-catalyzed, nucleophilic thiol-ene/radical-mediated thiol-yne reactions and the facile orthogonal synthesis of polyfunctional materials.
abstract: The first example of highly efficient sequential thiol-ene/thiol-yne reactions conducted in an orthogonal manner is presented and its broad application in the synthesis of polyfunctional materials demonstrated. The anionic chain mechanism of the phosphine-mediated thiol-ene reaction is highlighted, as is the radical-mediated thiol-yne reaction. Kinetic data for a model reaction are presented, followed by a discussion of the synthesis of a range of materials with diverse functionality, including an example of potential biomedical significance.
authors.affiliation: School of Polymers and High Performance Materials, The University of Southern Mississippi, 118 College Drive #10076, Hattiesburg, Mississippi 39406-10076, USA.
authors.forename: Justin W
authors.initials: JW
authors.lastname: Chan
authors.forename: Charles E
authors.initials: CE
authors.lastname: Hoyle
authors.forename: Andrew B
authors.initials: AB
authors.lastname: Lowe