Heritability and linkage analysis of appendicitis utilizing age at onset.
Appendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3.
Oldmeadow
Christopher
C
Department of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia. c.oldmeadow@student.qut.edu.au
Mengersen
Kerrie
K
Martin
Nicholas
N
Duffy
David L
DL