Ileal tract and Peyer's patch innervation in scrapie-free versus scrapie-affected ovines.
Ileal Peyer's patches (PPs) are involved early during sheep scrapie infection. This study qualitatively and semi-quantitatively evaluated ileal tract and PP innervation in 29 Sarda ovines of different age, PrP genotype and scrapie status. A prominent network of fibres was detected within PPs, mainly located in interfollicular lymphoid and stromal components. Intrafollicular fibres were rarely observed, with no apparent differences between scrapie-free and scrapie-affected animals, or among ovines carrying different PrP genotypes. In adult sheep, independent of their scrapie status, nerve fibres could be detected infrequently, close to the follicle-associated epithelium. Fibres were also detected within newly formed follicles and intrafollicular microgranulomas.
Marruchella
G
G
Department of Comparative Biomedical Sciences, University of Teramo, Italy.
Ligios
C
C
Baffoni
M
M
Cancedda
M G
MG
Demontis
F
F
Donatucci
G
G
Chiocchetti
R
R
Clavenzani
P
P
Lalatta-Costerbosa
G
G
Di Guardo
G
G