title: Effects of a synbiotic product on blood antioxidative activity in subjects colonized with Helicobacter pylori.
abstract: OBJECTIVE
  To evaluate the impact of the consumption of a synbiotic product on the antioxidative activity markers of blood in asymptomatic H. pylori-colonized persons.
  
  
  RESULTS
  Fifty-three healthy adult volunteers without gastric symptoms participated in a randomized, double-blind placebo-controlled study. The crossover consumption of the enterocoated capsules containing antioxidative Lactobacillusfermentum ME-3, Lact. paracasei 8700:2 and Bifidobacterium longum 46 with Raftilose P95 lasted for 3 weeks and did not change the H. pylori colonization. In H. pylori-positive subjects the sera values of total antioxidative status (TAS) were significantly lower compared to H. pylori-negative subjects (0.97 vs 1.05 mmol l(-1), P = 0.008). After the consumption of the synbiotic, TAS values (0.97 vs 1.03 mmol l(-1), P = 0.004) increased, while the ratio between oxidized and reduced glutathione (0.035 vs 0.030, P = 0.016) decreased in H. pylori-positive subjects.
  
  
  CONCLUSIONS
  The consumption of a synbiotic containing an antioxidative probiotic strain improved the reduced systemic antioxidative activity in H. pylori-colonized asymptomatic subjects.
  
  
  CONCLUSIONS
  A synbiotic product containing an antioxidative probiotic strain may be useful in the reduction of systemic oxidative stress in H. pylori infection.
authors.affiliation: Department of Microbiology, Medical Faculty, University of Tartu, Tartu, Estonia. pirje.hutt@ut.ee
authors.forename: P
authors.initials: P
authors.lastname: Hütt
authors.forename: H
authors.initials: H
authors.lastname: Andreson
authors.forename: T
authors.initials: T
authors.lastname: Kullisaar
authors.forename: T
authors.initials: T
authors.lastname: Vihalemm
authors.forename: E
authors.initials: E
authors.lastname: Unt
authors.forename: J
authors.initials: J
authors.lastname: Kals
authors.forename: P
authors.initials: P
authors.lastname: Kampus
authors.forename: M
authors.initials: M
authors.lastname: Zilmer
authors.forename: M
authors.initials: M
authors.lastname: Mikelsaar