The latest interleukin: IL-33 the novel IL-1-family member is a potent mast cell activator.
IL-33, a member of IL-1 family, induces the differentiation of T-cells (depending on the phosphorylation of MAPKs and NF-kB) and is involved in T-cell mediated immune responses. IL-33 is also involved in the production of IL-5, IL-4 and IL-13 and several chemokines. In this editorial we show the importance of IL-33 in allergic diseases and its role as an inflammatory cytokine. In addition, the induction of certain chemokines by IL-33 may candidate this new cytokine as a mediator in inflammatory and autoimmune diseases and may prove to be a therapeutic target for the prevention of these diseases.
Castellani
M L
ML
Kempuraj
D
D
Salini
V
V
Vecchiet
J
J
Tete
S
S
Ciampoli
C
C
Conti
F
F
Cerulli
G
G
Caraffa
A
A
Antinolfi
P
P
Theoharides
T C
TC
De Amicis
D
D
Perrella
A
A
Cuccurullo
C
C
Boscolo
P
P
Shaik
Y
Y