title: A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
abstract: Crystal structures of A-form and B-form DNA duplexes containing 2'-S-methyl-uridines reveal that the modified residues adopt a RNA-like C3'-endo pucker, illustrating that the replacement of electronegative oxygen at the 2'-carbon of RNA by sulfur does not appear to fundamentally alter the conformational preference of the sugar in the oligonucleotide context and sterics trump stereoelectronics.
authors.affiliation: Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
authors.forename: Pradeep S
authors.initials: PS
authors.lastname: Pallan
authors.forename: Thazha P
authors.initials: TP
authors.lastname: Prakash
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Robert L
authors.initials: RL
authors.lastname: Eoff
authors.forename: Muthiah
authors.initials: M
authors.lastname: Manoharan
authors.forename: Martin
authors.initials: M
authors.lastname: Egli