title: Enantioselective syntheses of both enantiomers of noranabasamine.
abstract: Both the R and S enantiomers of the amphibian alkaloid noranabasamine were prepared in >30% overall yield with 80% ee and 86% ee, respectively. An enantioselective iridium-catalyzed N-heterocyclization reaction with either (R)- or (S)-1-phenylethylamine and 1-(5-methoxypyridin-3-yl)-1,5-pentanediol was employed to generate the 2-(pyridin-3-yl)-piperidine ring system in 69-72% yield.
authors.affiliation: Department of Chemistry, University of New Orleans, New Orleans, Louisiana 70148, USA.
authors.forename: Lei
authors.initials: L
authors.lastname: Miao
authors.forename: Stassi C
authors.initials: SC
authors.lastname: Dimaggio
authors.forename: Hong
authors.initials: H
authors.lastname: Shu
authors.forename: Mark L
authors.initials: ML
authors.lastname: Trudell