title: CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype.
abstract: OBJECTIVE
  To evaluate the possible contribution of the (TTTA)n polymorphism of aromatase gene (CYP19) to the hyperandrogenic phenotype of polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  Endocrine outpatients' clinic of a tertiary university hospital.
  
  
  METHODS
  One hundred eighty women with PCOS and 160 healthy controls of reproductive age.
  
  
  METHODS
  Blood sampling for genotype analysis, and measurement of androgens, E(2), LH, FSH, and fasting glucose and insulin.
  
  
  METHODS
  Frequency of the CYP19(TTTA)n polymorphism and association with hormone concentrations.
  
  
  RESULTS
  Women with PCOS tended to have more frequently short (TTTA)n alleles (with nine or fewer repeats) than healthy controls (33.1% vs. 29.5%), although the difference was not statistically significant. However, patients in the highest quartile for serum T were more frequently homozygous for short alleles compared with controls (59.1% vs. 42.1%) and patients in lower quartiles (59.1% vs. 36.9%). Furthermore, the patients homozygous for short alleles had higher T/E(2) ratios, higher T levels, and higher LH/FSH ratios compared with those with longer alleles.
  
  
  CONCLUSIONS
  Although CYP19 may not be a major genetic determinant of PCOS, it may act as a genetic modifier of the hyperandrogenic phenotype of PCOS. The presence of short CYP19(TTTA)n alleles may contribute to prenatal androgenization programming the development of PCOS phenotype in adult life.
authors.affiliation: Department of Endocrinology, University of Ioannina, Ioannina, Greece.
authors.forename: Nectaria
authors.initials: N
authors.lastname: Xita
authors.forename: Leandros
authors.initials: L
authors.lastname: Lazaros
authors.forename: Ioannis
authors.initials: I
authors.lastname: Georgiou
authors.forename: Agathocles
authors.initials: A
authors.lastname: Tsatsoulis