title: Initial bone regeneration around fenestrated implants in Beagle dogs using basic fibroblast growth factor-gelatin hydrogel complex with varying biodegradation rates.
abstract: OBJECTIVE
  The purpose of this study was to compare the effectiveness of fast and slow biodegradation of basic fibroblast growth factor (bFGF)-gelatin hydrogel complex on bone regeneration around fenestrated implants as a new augmentation drug delivery system.
  
  
  METHODS
  Nine titanium implants (3.3mm diameter and 10mm length) were placed into the edentulous areas of the mandibles of three adult beagle dogs with four screws exposed at the upper buccal side. The effectiveness of bFGF-gelatin hydrogel complexes of varying degradation types used to cover implant screws without membrane were compared with 1 microg and 10 microg bFGF-98 wt% gelatin as the fast degradation type and 10 microg bFGF-95 wt% gelatin as the slow degradation type. After 4 weeks, bone regeneration around the screws was evaluated histologically and histomorphometrically.
  
  
  RESULTS
  With use of 10 microg bFGF, regenerated bone around exposed screws was clearly seen in both the fast and slow degradation type groups. In contrast, little bone formation was seen in the fast degradation-type group with 1 microg bFGF. Height of regenerated bone for the slow degradation-type complex group was significantly greater than for the fast degradation-type group with 1 microg bFGF (P<0.05).
  
  
  CONCLUSIONS
  These results suggest that use of slow degradation-type bFGF-gelatin hydrogel complex may accelerate bone regeneration around fenestrated implants at an early stage of bone regeneration.
authors.affiliation: Department of Advanced Prosthodontics, Division of Cervico-Gnathostomatology, Hiroshima University Graduate School of Biomedical Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. moritak@hiroshima-u.ac.jp
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Akagawa
authors.forename: Takayasu
authors.initials: T
authors.lastname: Kubo
authors.forename: Katsunori
authors.initials: K
authors.lastname: Koretake
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hayashi
authors.forename: Kazuya
authors.initials: K
authors.lastname: Doi
authors.forename: Ayumu
authors.initials: A
authors.lastname: Matsuura
authors.forename: Koji
authors.initials: K
authors.lastname: Morita
authors.forename: Ryou
authors.initials: R
authors.lastname: Takeshita
authors.forename: Quan
authors.initials: Q
authors.lastname: Yuan
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata