An infant with self-healing cutaneous Langerhans cell histiocytosis followed by isolated thymic relapse.
Thymic involvement with Langerhans cell histiocytosis (LCH) typically occurs in children as part of multi-system (M-S) LCH. Patients who develop skin-only LCH during infancy may either follow a self-healing course with spontaneous regression or may progress to M-S involvement. We describe a male infant who developed isolated thymic LCH after spontaneous complete regression of isolated cutaneous lesions. His erythrocyte sedimentation rate and C-reactive protein increased temporarily during the skin-only stage of LCH, and increased again considerably during the thymic relapse. Even for patients with skin-only LCH, these laboratory data might indicate possible relapse or late progression of the disease.
Hatakeyama
Naoki
N
Department of Pediatrics, Sapporo Medical University School of Medicine, Sapporo, Hokkaido, Japan. nhatake@sapmed.ac.jp
Hori
Tsukasa
T
Yamamoto
Masaki
M
Sogawa
Ineko
I
Inazawa
Natsuko
N
Tsutsumi
Hiroyuki
H
Suzuki
Nobuhiro
N