Water-triggered, counter-anion-controlled, and silver-phosphines complex-catalyzed stereoselective cascade alkynylation/cyclization of terminal alkynes with salicylaldehydes.
A highly efficient alkynylation-cyclization of terminal alkynes with salicylaldehydes leading to substituted 2,3-dihydrobenzofuran-3-ol derivatives was developed by using Cy(3)P-silver complex as catalyst in water. Counter anions in the silver complex proved to be the key factor to Z/E stereoselectivity control. Aurones can also be obtained effectively from the cascade reaction followed by oxidation without further purification.
Yu
Min
M
Department of Applied Chemistry, School of Material Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, PR China.
Skouta
Rachid
R
Zhou
Lei
L
Jiang
Huan-feng
HF
Yao
Xiaoquan
X
Li
Chao-Jun
CJ