Segmental duplications contribute to gene expression differences between humans and chimpanzees.
In addition to specific changes in cis- and trans-regulatory elements, structural changes in the genome are hypothesized to underlie a large number of differences in gene expression between species. Accordingly, we show that species-specific segmental duplications are enriched with genes that are differentially expressed between humans and chimpanzees.
Blekhman
Ran
R
Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia.
Oshlack
Alicia
A
Gilad
Yoav
Y