title: Single-nucleotide polymorphisms in the promoter of the CDK5 gene and lung cancer risk in a Korean population.
abstract: Cyclin-dependent kinase 5 (CDK5), a proline-directed serine/threonine kinase, which was originally known for its regulatory role in neuronal activities, has recently been suggested to play a role in extraneuronal activities. For example, a recent study detected overexpression of the CDK5 gene in non-small-cell lung cancer. Therefore, in order to explore the association of the CDK5 gene with lung cancer risk in a Korean population, the genotypes of the CDK5 promoter region were determined in 407 lung cancer patients and 402 normal participants. The result showed that the -904 G>A genotype affected susceptibility to lung cancer risk (odd ratios (OR)=1.53, 95% confidence interval (CI)=1.02-2.32). Furthermore, subsequent haplotype analysis of three single-nucleotide polymorphism (SNP) regions suggested that the A-G-C haplotype was associated with a higher overall risk of lung cancer (OR=1.59, 95% CI=1.16-2.18). These results suggest that CDK5 promoter polymorphisms contribute to the genetic susceptibility to lung cancer in the Korean population.
authors.affiliation: Genomic Research Center for Lung and Breast/Ovarian Cancers, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Hyo Seon
authors.initials: HS
authors.lastname: Choi
authors.forename: Youngin
authors.initials: Y
authors.lastname: Lee
authors.forename: Kyong Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Jae Sook
authors.initials: JS
authors.lastname: Sung
authors.forename: Jong-Eun
authors.initials: JE
authors.lastname: Lee
authors.forename: Eun-Soon
authors.initials: ES
authors.lastname: Shin
authors.forename: Jeong-Seon
authors.initials: JS
authors.lastname: Ryu
authors.forename: Yeul Hong
authors.initials: YH
authors.lastname: Kim