title: The IL-23/Th17 axis in the immunopathogenesis of psoriasis.
abstract: Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis.
authors.affiliation: St John's Institute of Dermatology, King's College London School of Medicine and NIHR Biomedical Research Centre, London, UK.
authors.forename: Antonella
authors.initials: A
authors.lastname: Di Cesare
authors.forename: Paola
authors.initials: P
authors.lastname: Di Meglio
authors.forename: Frank O
authors.initials: FO
authors.lastname: Nestle