Efficient diastereoselective synthesis of trifarane-type sesquiterpenes, trifarienols A and B.
Diastereoselective total synthesis of trifarienols A and B, trifarane-type sesquiterpenes isolated from the Malaysian Cheilolejeunea trifaria, was achieved via an intramolecular Hosomi-Sakurai reaction of the aldehyde to construct a substituted bicyclo[3.3.1]nonane skeleton having the exo-methylene moiety of the target compounds in one step.
Takahashi
Kazunori
K
Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41, Shinagawa-ku, Tokyo 142-8501, Japan.
Akao
Ryuichi
R
Honda
Toshio
T