[Possible role of peroxisomes and glyoxylate cycle in regulation of metabolism in ruminant animals].
The concept of possible functioning subcellular organelles peroxysomes in an organism of ruminants is put forward and discussed some positions of this concept. Hypothetically, and also with attraction of own experimental material and data from the literature, is postulated the potential opportunity initiation and functioning in peroxysomes of glyoxylate cycle is assumed. The existence of glyoxylate cycle not only in rumen microflora, but also its applicability to decoding the some mechanisms of a metabolism regulation in cells of various tissues of ruminants with different growth intensity is supposed. The physiological essence of put forward positions will consist in the following: 1) glyoxylate cycle functioning in peroxysomes not only simbyotic microflorae of pre-stomaches (rumen), but also in bodies of ruminants, involves in a metabolism and synthesis of glucose, as a product of a rumenal fermentation a lactic acid (through piruvate and acetyl CoA), and acetate of rumenal origin and synthesized in reactions of lipids beta-oxidation; 2) In peroxysomes take place processes of beta-oxidation of fatt acids, which maximum activity in the period of the greatest activity of a metabolism and decrease of mitochondrial beta-oxidation of lipids; 3) one of key metabolites of peroxysomal reactions considers cisteamin, having expressed an antioxidant and radioprotector properties, and being simultaneously the negative endocellular messenger of insulin; 4) Two-carbon fragments of peroxysomal reactions (glycolat and glyoxylate) are inhibitors of series reactions in a cells including citrate cycle, terminal oxidation, piruvatdehylrogenase and piruvatcarboxylase and strengthen a stream of metabolites in peroxysomales reactions; 5) formed in significant amounts in peroxysomes peroxide of hydrogen, having insulin-like action, influences a number of processes in an organism, including utilisation of glucose and synthesis of muscular fibers; 6) the close interrelation between peroxysomes and mitochondria is carried out at a level of coordination of processes making energy, biosynthetic and antioxidant processes.
Galochkina
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Galochkin
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