[Nonlinear nature of the antiarrhythmic effects of lidocain].
For the first time experimental evidence for the nonlinear dependence of the antiarrhythmic effect of the Na-channel blocker on its concentration was obtained. The experiments were carried out with the use of a preparation of the mammalian heart wall. As a blockator, lidocain was used. It was found that the dependence of the antiarrhythmic effect of lidocain on its concentration has a well-pronounced nonlinear nature: while its therapeutic concentrations make ventricular arrhythmias more monomorphic, low concentrations of lidocain increase the probability for the arrhythmias to appear more polymorphic.
Moskalenko
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