[Cellular therapy in autoimmune disease].
In addition to natural thymus-derived regulatory T-cells (Tregs), peripherally-induced Tregs are of central importance in immune homeostasis. Homotypic interactions between activated effector T-cells and resting memory T-cells induced the generation of IL-10 and IFNgamma producing Tregs in vitro. This mechanism in Treg development allows new insights into T-cell vaccination, which has been employed in pilot trials of multiple sclerosis and rheumatoid arthritis with promising results.
Thümmler
K
K
Rheumaeinheit, Medizinische Poliklinik, Klinikum der Universität München, Pettenkoferstrasse 8a, Munich, Germany. katja.thuemmler@med.uni-muenchen.de
Ramming
A
A
Schulze-Koops
H
H
Skapenko
A
A