Synthesis of 2-ene-1,4-diols by a new cascade-opening of 1,3-diepoxides: towards an efficient synthesis of dihydroxytaxoid derivatives.
Taxing taxanes: A new method for the preparation of alk-2-ene-1,4-diols from 1,3-dienes, especially for geometrical constrained derivatives, via dioxirane derivative formation followed by Ti(III)-induced oxirane ring opening, is described. The strategy has been very efficiently implemented to the construction of the 11-ene-10,13-diol moiety present in taxol derivatives.
Aldegunde
María J
MJ
Departamento de Química Orgánica, Facultad de Química, Universidad de Santiago, 15782 Santiago de Compostela, Spain.
Castedo
Luis
L
Granja
Juan R
JR