title: Revised structure and synthesis of celastramycin a, a potent innate immune suppressor.
abstract: After searching for natural substances that regulate innate immunity using the ex vivo Drosophila culture system, a benzoyl pyrrole-type compound, celastramycin A, was identified and isolated as a potent suppressor. By synthesizing the previously reported structure 1 and another benzoyl pyrrole-type compound 2 reported in a Japanese patent, the correct structure of celastramycin A was confirmed to be 2. Compound 2 suppressed the production of IL-8 (IC(50) 0.06 microg/mL) in human umbilical vein endothelial cells (HUVECs).
authors.affiliation: Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba-yama, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Mizuki
authors.initials: M
authors.lastname: Sekiya
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katou
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ueda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kabeya
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Kurata
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima