title: Functional and anatomic results of amnion vaginoplasty in young women with Mayer-Rokitansky-Küster-Hauser syndrome.
abstract: OBJECTIVE
  To evaluate the surgical outcome and the long-term anatomic and functional results in young women with Mayer-Rokitansky-Küster-Hauser Syndrome (MRKH) undergoing neovaginal creation with amniotic membranes.
  
  
  METHODS
  Evaluation of surgical and functional outcome according to clinical records and validated questionnaires about sexuality (Female Sexual Function Index [FSFI]) over a 1.5-year follow-up period.
  
  
  METHODS
  University hospital and referral center for pediatric and adolescent gynecology.
  
  
  METHODS
  Seven patients with congenital vaginal aplasia with a mean age of 20.86 +/- 3.56 years (range 17-26 years).
  
  
  METHODS
  McIndoe procedure modified by the application of human freeze-dried amniotic membranes.
  
  
  METHODS
  Anatomic success was defined by a vaginal length >or=8 cm, and a width allowing the easy introduction of two fingers. FSFI scores were applied to define functional results.
  
  
  RESULTS
  Mean neovaginal length was 9.3 cm (range 4-12 cm). The mean FSFI score was 30.0 +/- 6.9. Major operative complications occurred in one patient. In six out of seven patients satisfactory anatomic and functional results were achieved.
  
  
  CONCLUSIONS
  The surgical dissection of the vesicorectal space and the application of human amnion over a vaginal mold to create a neovagina results in satisfying anatomic and functional outcome with low perioperative morbidity in MRKH patients.
authors.affiliation: Department of Gynecology and Obstetrics, Charité, Campus Virchow Clinic, University Hospital, Berlin, Germany. christina.fotopoulou@charite.de
authors.forename: Christina
authors.initials: C
authors.lastname: Fotopoulou
authors.forename: Jalid
authors.initials: J
authors.lastname: Sehouli
authors.forename: Nicole
authors.initials: N
authors.lastname: Gehrmann
authors.forename: Ines
authors.initials: I
authors.lastname: Schoenborn
authors.forename: Werner
authors.initials: W
authors.lastname: Lichtenegger