Bioinspired interface for nanobiodevices based on phospholipid polymer chemistry.
This review paper describes novel biointerfaces for nanobiodevices. Biocompatible and non-biofouling surfaces are designed largely based on cell membrane structure, and the preparation and functioning of the bioinspired interface are evaluated and compared between living and artificial systems. A molecular assembly of polymers with a phospholipid polar group has been developed as the platform of the interface. At the surface, protein adsorption is effectively reduced and the subsequent bioreactions are suppressed. Through this platform, biomolecules with a high affinity to the specific molecules are introduced under mild conditions. The activity of the biomolecules is retained even after immobilization. This bioinspired interface is adapted to construct bionanodevices, that is, microfluidic chips and nanoparticles for capturing target molecules and cells. The interface functions well and has a very high efficiency for biorecognition. This bioinspired interface is a promising universal platform that integrates various fields of science and has useful applications.
Ishihara
Kazuhiko
K
Department of Materials Engineering, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. ishihara@mpc.t.u-tokyo.ac.jp
Takai
Madoka
M