title: Reactivation of BK Virus in the Early Period After Kidney Transplantation.
abstract: BACKGROUND
  Typically, polyoma BK virus (BKV) remains latent in the urogenital tract after primary infection. Reactivation of BKV in recipients of kidney allografts can cause progressive graft dysfunction known as BK virus nephropathy (BKVN). The cornerstone of treatment for BKVN is prevention; therefore, it is important to detect BKV reactivation early and reduce immunosuppression. We sought to identify the BKV reactivation rate and associated factors in a prospective study.
  
  
  METHODS
  We studied 37 consecutive unselected adult recipients who underwent deceased donor kidney transplantation in 2007 and completed at least 3 months of observation. Qualitative nested polymerase chain reaction (PCR) testing was performed to detect BKV DNA in urine and plasma specimens.
  
  
  RESULTS
  In all cases, BK viremia or viruria was not detected on the postoperative day or 2 weeks thereafter. At 3 months, BKV reactivation developed in 6 (16%) of 37 recipients. Simultaneous viremia and viruria were present on 5 patients and viremia only in 1 patient. Significant risk factors for BK viremia were body mass index >30 kg/m(2) (P = .02), retransplantation (P =.04), and use of tacrolimus (P = .02). Serum creatinine values at 3 months after transplantation were significantly higher among patients with active BKV infection (P = .008).
  
  
  CONCLUSIONS
  Early BKV reactivation is associated with worse graft function as early as 3 months after transplantation. Obesity, retransplantation, and use of tacrolimus were factors promoting early development of BKV viremia.
authors.affiliation: P. Stradina Clinical University Hospital, Department of Transplantation, Riga, Latvia; Riga Stradins University, Riga, Latvia. ieva-z@navigator.lv
authors.forename: I
authors.initials: I
authors.lastname: Ziedina
authors.forename: I
authors.initials: I
authors.lastname: Folkmane
authors.forename: S
authors.initials: S
authors.lastname: Chapenko
authors.forename: M
authors.initials: M
authors.lastname: Murovska
authors.forename: A
authors.initials: A
authors.lastname: Sultanova
authors.forename: J
authors.initials: J
authors.lastname: Jushinskis
authors.forename: R
authors.initials: R
authors.lastname: Rozental