title: Zafirlukast (Accolate): A new treatment for capsular contracture.
abstract: BACKGROUND
  Capsular contracture after breast augmentation or reconstructive breast surgery is a difficult problem. Previous studies have suggested that alteration of the inflammatory response could have a role in reducing the incidence of capsular contracture.
  
  
  OBJECTIVE
  We report a series of patients with Baker class III or IV capsular contracture who underwent treatment with zafirlukast.
  
  
  METHODS
  Patients received a regimen of zafirlukast 20 mg by mouth 2 times daily for 3 months.
  
  
  RESULTS
  In many cases, dramatic softening of the breast capsule was evident after 1 to 3 months of treatment.
  
  
  CONCLUSIONS
  Zafirlukast appears to effectively soften early capsular contracture and may prevent the formation of capsular contracture in those patients at risk. (Aesthetic Surg J 2002;22:329-336.).
authors.forename: S Larry
authors.initials: SL
authors.lastname: Schlesinger
authors.forename: Richard
authors.initials: R
authors.lastname: Ellenbogen
authors.forename: Michael N
authors.initials: MN
authors.lastname: Desvigne
authors.forename: Steven
authors.initials: S
authors.lastname: Svehlak
authors.forename: Robert
authors.initials: R
authors.lastname: Heck