Mast cells and angiogenesis in haematological malignancies.
Tumor cells are surrounded by an infiltrate of inflammatory cells, namely lymphocytes, neutrophils, macrophages and mast cells (MCs). Increasing evidence indicates that MCs play a role in tumor growth and tumor-related angiogenesis in both solid and haematological tumors. In this review article, we discuss the involvement of MCs in angiogenesis in haematological malignancies and suggest that MCs might act as a new target for the adjuvant treatment of these tumors through the selective inhibition of angiogenesis.
Ribatti
Domenico
D
Department of Human Anatomy and Histology, University of Bari Medical School, Piazza G. Cesare, 11 Policlinico, 70124 Bari, Italy. ribatti@anatomia.uniba.it
Crivellato
Enrico
E
Molica
Stefano
S