Construction of carbo- and heterocycles using radical relay cyclizations initiated by alkoxy radicals.
An efficient method for the rapid construction of carbo- and heterocycles has been developed using radical relay cyclizations initiated by alkoxy radicals. Linear substrates were cyclized to form a wide range of cyclopentane, pyrrolidine, tetrahydropyran, and tetrahydrofuran derivatives in excellent yields. This methodology was utilized as a key step in the synthesis of the tetrahydrofuran fragment in (-)-amphidinolide K.
Zhu
Hai
H
Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
Wickenden
Jason G
JG
Campbell
Natalie E
NE
Leung
Joe C T
JC
Johnson
Kayli M
KM
Sammis
Glenn M
GM