Formation of ordered cellular structures in suspension via label-free negative magnetophoresis.
The creation of ordered cellular structures is important for tissue engineering research. Here, we present a novel strategy for the assembly of cells into linear arrangements by negative magnetophoresis using inert, cytocompatible magnetic nanoparticles. In this approach, magnetic nanoparticles dictate the cellular assembly without relying on cell binding or uptake. The linear cell structures are stable and can be further cultured without the magnetic field or nanoparticles, making this an attractive tool for tissue engineering.
Krebs
Melissa D
MD
Department of Biomedical Engineering, Case Western Reserve University, 204 Wickenden, 10900 Euclid Avenue, Cleveland, Ohio 44106, USA.
Erb
Randall M
RM
Yellen
Benjamin B
BB
Samanta
Bappaditya
B
Bajaj
Avinash
A
Rotello
Vincent M
VM
Alsberg
Eben
E