title: A wireless bio-MEMS sensor for C-reactive protein detection based on nanomechanics.
abstract: A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-microm-long microelectromechanical systems (MEMS) microcantilever housed in a 7 x 7 mm(2) reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 microm CMOS process. CRP concentrations from 1 microg/mL to 500 microg/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.
authors.affiliation: Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan 106, ROC.
authors.forename: Chun-Hao
authors.initials: CH
authors.lastname: Chen
authors.forename: Rong-Zhang
authors.initials: RZ
authors.lastname: Hwang
authors.forename: Long-Sun
authors.initials: LS
authors.lastname: Huang
authors.forename: Shi-Ming
authors.initials: SM
authors.lastname: Lin
authors.forename: Hsiao-Chin
authors.initials: HC
authors.lastname: Chen
authors.forename: Yu-Che
authors.initials: YC
authors.lastname: Yang
authors.forename: Yu-Tso
authors.initials: YT
authors.lastname: Lin
authors.forename: Shih-An
authors.initials: SA
authors.lastname: Yu
authors.forename: Yo-Sheng
authors.initials: YS
authors.lastname: Lin
authors.forename: Yiao-Hong
authors.initials: YH
authors.lastname: Wang
authors.forename: Nai-Kuan
authors.initials: NK
authors.lastname: Chou
authors.forename: Shey-Shi
authors.initials: SS
authors.lastname: Lu