title: Topical and oral voriconazole in the treatment of fungal keratitis.
abstract: We describe two patients with fungal keratitis refractory to standard antifungal therapy whose conditions were managed with voriconazole. The first case is a patient with endophthalmitis and corneal ulcer due to Candida parapsilosis after receiving a corneal transplant. The patient was treated with amphotericin but showed no signs of improvement. Topical voriconazole, oral voriconazole, and intravitreal voriconazole yielded signs of improvement. The second case is a 63-year-old male who underwent a month of empiric treatment with 0.2% topical amphotericin for fungal keratitis but showed no signs of improvement. Treatment was then provided with 1% voriconazole. Both cases showed effective treatment with voriconazole. Voriconazole may be considered as a new method to treat fungal keratitis refractory to standard antifungal therapy.
authors.affiliation: Department of Ophthalmology, College of Medicine, Kosin University, Busan, Korea.
authors.forename: Sang Joon
authors.initials: SJ
authors.lastname: Lee
authors.forename: Jung Joo
authors.initials: JJ
authors.lastname: Lee
authors.forename: Shin Dong
authors.initials: SD
authors.lastname: Kim