Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.
In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
Arnold
Paul Daniel
PD
Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8. paul.arnold@sickkids.ca
Macmaster
Frank P
FP
Richter
Margaret A
MA
Hanna
Gregory L
GL
Sicard
Tricia
T
Burroughs
Eliza
E
Mirza
Yousha
Y
Easter
Phillip C
PC
Rose
Michelle
M
Kennedy
James L
JL
Rosenberg
David R
DR