The highly enantioselective phase-transfer catalytic mono-alkylation of malonamic esters.
The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-alpha-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality.
Kim
Mi-Hyun
MH
Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
Choi
Sea-Hoon
SH
Lee
Yeon-Ju
YJ
Lee
Jihye
J
Nahm
Keepyung
K
Jeong
Byeong-Seon
BS
Park
Hyeung-Geun
HG
Jew
Sang-Sup
SS