Synthesis and biological evaluation of technetium-labeled D-glucose-MAG3 derivative as agent for tumor diagnosis.
A d-glucose-MAG(3) derivative was successfully synthesized and radiolabeled in high labeling yield. Biodistribution studies in Ehrlich tumor-bearing mice were performed. This compound showed high accumulation in tumor tissue with high tumor-to-muscle ratio and moderate tumor-to-blood ratio. Thus, d-glucose-MAG(3) is a potential agent for tumor diagnosis.
de Barros
André Luís Branco
AL
Faculdade de Farmácia, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, 31279-901 Belo Horizonte, Minas Gerais, Brazil.
Cardoso
Valbert Nascimento
VN
Mota
Luciene das Graças
Ld
Leite
Elaine Amaral
EA
Oliveira
Mônica Cristina de
MC
Alves
Ricardo José
RJ