title: Evaluation of sphingolipids in Wistar rats treated to prolonged and single oral doses of fumonisin b₁.
abstract: The objective of the present study was to evaluate sphingolipid levels (sphingosine-So and sphinganine-Sa) and to compare the Sa/So ratio in liver, serum and urine of Wistar rats after prolonged administration (21 days) of fumonisin B(1) (FB(1)). In parallel, the kinetics of sphingolipid elimination in urine was studied in animals receiving a single dose of FB(1). Prolonged exposure to FB(1) caused an increase in Sa levels in urine, serum and liver. The most marked effect on sphingolipid biosynthesis was observed in animals treated with the highest dose of FB(1). Animals receiving a single dose of FB(1) presented variations in Sa and So levels and in the Sa/So ratio.
authors.affiliation: Departamento de Microbiologia e Imunologia, Instituto de Veterinária da Universidade Federal Rural do Rio de Janeiro, CEP 23890.000, Rio de Janeiro, RJ, Brasil.
authors.forename: Glória M
authors.initials: GM
authors.lastname: Direito
authors.affiliation: Departamento de Bromatologia e Química do Instituto Adolfo Lutz, CEP. 01246-902, São Paulo, Brasil.
authors.forename: Adriana P
authors.initials: AP
authors.lastname: Almeida
authors.affiliation: Instituto de Pesquisa Energéticas e Nucleares (IPEN / CNEN - SP), CEP 05508-000, São Paulo, SP, Brasil.
authors.forename: Simone
authors.initials: S
authors.lastname: Aquino
authors.affiliation: Departamento de Microbiologia do Instituto de Ciências Biomédicas da Universidade de São Paulo, CEP: 05508-900, São Paulo, SP, Brasil.
authors.forename: Tatiana
authors.initials: T
authors.lastname: Alves Dos Reis
authors.affiliation: Instituto de Zootecnia, Nova Odessa, 13460-000, SP, Brasil.
authors.forename: Claudia
authors.initials: C
authors.lastname: Rodrigues Pozzi
authors.affiliation: Departamento de Microbiologia do Instituto de Ciências Biomédicas da Universidade de São Paulo, CEP: 05508-900, São Paulo, SP, Brasil.
authors.forename: Benedito
authors.initials: B
authors.lastname: Corrêa