title: The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents.
abstract: Starting from a non-selective pyrazolo-pyrimidone lead, the sequential use of parallel medicinal chemistry and directed synthesis led to the discovery of potent, highly selective, and orally bioavailable PDE9 inhibitors. The availability of these tools allowed for a thorough evaluation of the therapeutic potential of PDE9 inhibition.
authors.affiliation: Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA.
authors.forename: Michael P
authors.initials: MP
authors.lastname: Deninno
authors.forename: Melissa
authors.initials: M
authors.lastname: Andrews
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Bell
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Cynthia
authors.initials: C
authors.lastname: Eller-Zarbo
authors.forename: Nan
authors.initials: N
authors.lastname: Eshelby
authors.forename: John B
authors.initials: JB
authors.lastname: Etienne
authors.forename: Dianna E
authors.initials: DE
authors.lastname: Moore
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Palmer
authors.forename: Michael S
authors.initials: MS
authors.lastname: Visser
authors.forename: Li J
authors.initials: LJ
authors.lastname: Yu
authors.forename: William J
authors.initials: WJ
authors.lastname: Zavadoski
authors.forename: E
authors.initials: E
authors.lastname: Michael Gibbs