title: Genetic polymorphisms in glutathione S-transferases and cytochrome P450s, tobacco smoking, and risk of non-Hodgkin lymphoma.
abstract: We investigated variation in glutathione S-transferases (GSTs) and cytochrome P450s (CYPs), and smoking in a population-based case-control study of NHL including 1,115 women. Although risk of NHL was not altered by variant polymorphisms in GSTs or CYPs, it was significantly changed for DLBCL when considered in conjunction with smoking behavior, though only in nonsmokers. An increased risk of DLBCL in nonsmokers was associated with the variant G allele for GSTP1 (OR = 1.6, 95% CI 1.0-2.3) and CYP1A1 (OR = 2.4; 95% CI 1.0-5.7), but a decreased risk for the variant G allele for CYP1B1 (OR = 0.6, 95% CI 0.4-1.0). Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.
authors.affiliation: Department of Environmental Health Sciences, School of Epidemiology and Public Health, Yale University, New Haven, Connecticut 06520-8034, USA.
authors.forename: Briseis A
authors.initials: BA
authors.lastname: Kilfoy
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Xuesong
authors.initials: X
authors.lastname: Han
authors.forename: Qin
authors.initials: Q
authors.lastname: Qin
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Theodore
authors.initials: T
authors.lastname: Holford
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang