C/EBPalpha in leukemogenesis: identity and origin of the leukemia-initiating cell.
The role of the transcription factor CCATT/enhancer binding protein alpha (C/EBPalpha) as a lineage instructive determinant in myelopoiesis is widely accepted. Furthermore, early mutational events ultimately leading to acute myeloid leukemia (AML) often involve abrogation of C/EBPalpha expression and/or function. The main focus of this review is the progression from a preclinical state to AML, and which preleukemic cell population(s) might-in general and in particular in patients with CEBPA mutations-be a target for the secondary genetic and epigenetic events leading to this progression.
Schuster
Mikkel Bruhn
MB
Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
Porse
Bo Torben
BT