Relapse of primitive mediastinal lymphoma as a myeloid mass following beam autologous transplant and subsequent refractoriness to matched unrelated umbilical cord blood allograft.
Outlining the treatment for an unclassifiable lymphoid malignancy is often difficult. A highly undifferentiated lymphomatous mass that relapsed in spite of intense chemotherapy and autologous transplant is reported. At relapse, there was differentiation into myeloid lineage. Though remission was achieved with AML-type reinduction chemotherapy, the mass recurred post allogenic cord blood stem cell transplant.
Anoop
Parameswaran
P
Department of Pediatric Hemato-Oncology, Royal Marsden Hospital, Sutton SM2 5PT, Surrey, UK.
Lancaster
Donna L
DL
Ethell
Mark E
ME
Potter
Mike N
MN
Wotherspoon
Andrew
A