Synthesis of 1,3,4-thiadiazole derivatives as aminopeptidase N inhibitors.
Aminopeptidase N (APN) is a zinc-dependent ectopeptidase which plays an important role in the invasion of metastatic tumors. In this study, we report the synthesis and in vitro enzyme inhibition assay of 1,3,4-thiadiazole scaffold compounds. These new compounds have potent inhibitory activities toward APN with IC50 values in the micromolar range.
Li
Shao-Hua
SH
State Key Laboratory of Food Science and Technology, Nanchang University, PR China.
Li
Gang
G
Huang
Hui-Ming
HM
Xiong
Fang
F
Mai
Xi
X
Kuang
Bin-Hai
BH
Liu
Cheng-Mei
CM
Tu
Guo-Gang
GG