Vanadium-catalyzed asymmetric epoxidation of allylic alcohols in water.
Asymmetric V-catalyzed epoxidation of allylic alcohols can be carried out in water with chiral ligands, which incorporate sulfonamide and hydroxamic acid fragments. Furthermore, the reaction, notorious for its ligand-deceleration effect, in water turned into the ligand-accelerated process. By using this aqueous protocol, a range of allylic alcohols were epoxidized with up to 94% ee.
Malkov
Andrei V
AV
Department of Chemistry, WestChem, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom. a.malkov@lboro.ac.uk
Czemerys
Louise
L
Malyshev
Denis A
DA