title: The ketogenic diet: proposed mechanisms of action.
abstract: The ketogenic diet is a high-fat, low-carbohydrate diet used to treat drug-resistant seizures, especially in children. A number of possible mechanisms of action have been proposed to explain the anticonvulsant effects of the diet. Four of these hypothetical mechanisms are discussed in the present article: the pH hypothesis, the metabolic hypotheses, the amino acid hypothesis, and the ketone hypothesis.
authors.affiliation: Department of Pharmacology and University of Toronto Epilepsy Research Program (UTERP), University of Toronto, Toronto, Ontario M5S 1A8, Canada.
authors.forename: Kirk
authors.initials: K
authors.lastname: Nylen
authors.forename: Sergei
authors.initials: S
authors.lastname: Likhodii
authors.forename: W McIntyre
authors.initials: WM
authors.lastname: Burnham