One-pot synthesis of alpha-carbolines via sequential palladium-catalyzed aryl amination and intramolecular arylation.
A one-pot synthesis of alpha-carbolines via a palladium-catalyzed aryl amination followed by intramolecular arylation is described. 2,3-Dichloro- and 2,3-dibromopyridines have been shown to react with readily available anilines to obtain various substituted alpha-carbolines in moderate to excellent yields.
Laha
Joydev K
JK
Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, Massachusetts 02139, USA.
Petrou
Philip
P
Cuny
Gregory D
GD