Organocatalytic enantioselective hetero-Diels-Alder reaction of aldehydes and o-benzoquinone diimide: synthesis of optically active hydroquinoxalines.
A highly enantioselective inverse electron demand hetero-Diels-Alder reaction of o-benzoquinone diimide and aldehydes has been developed by secondary amine catalysis, giving a facile protocol to access a variety of chiral hydroquinoxalines under mild conditions.
Li
Jun-Long
JL
Key laboratory of Drug-Targeting and Drug Deliver System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, China.
Han
Bo
B
Jiang
Kun
K
Du
Wei
W
Chen
Ying-Chun
YC