En route to (S)-selective chemoenzymatic dynamic kinetic resolution of aliphatic amines. One-pot KR/racemization/KR sequence leading to (S)-amides.
A one-pot sequential process, involving a radical racemization and an enzymatic resolution, provides access to (S)-amides, from racemic amines, with ee and yields ranging from 78 to 94% and 58 to 80%, respectively.
El Blidi
Lahssen
L
Equipe Chimie Moléculaire Organique, LCP UMR 6264, Boite 562, Université Paul Cezanne, Faculté des Sciences St Jérôme, Avenue Escadrille Normandie-Niemen, 13397 Marseille Cedex 20, France.
Nechab
Malek
M
Vanthuyne
Nicolas
N
Gastaldi
Stéphane
S
Bertrand
Michèle P
MP
Gil
Gérard
G