title: Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis.
abstract: The stem bark of Phoebe grandis afforded one new oxoproaporphine; (-)-grandine A (1), along with six known isoquinoline alkaloids: (-)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (-)-8,9-dihydrolinearisine (2) is also reported. The alkaloids' structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.
authors.affiliation: Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. matropi@um.edu.my
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: Ahmad Nazif
authors.initials: AN
authors.lastname: Aziz
authors.forename: Noel F
authors.initials: NF
authors.lastname: Thomas
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang