Timing of oocyte maturation and egg collection during controlled ovarian stimulation: a randomized controlled trial evaluating manual and automated measurements of follicle diameter.
OBJECTIVE
To evaluate the effect of a new automated technique of follicle measurement (Sono automated volume calculation [SonoAVC]) on the timing of oocyte maturation and subsequent oocyte retrieval.


METHODS
Prospective randomized controlled trial.


METHODS
University-based Assisted Conception Unit.


METHODS
Seventy-two women undergoing their first cycle of assisted reproduction treatment.


METHODS
The timing of final follicle maturation and oocyte retrieval based on follicle tracking with use of either conventional two-dimensional (2D) ultrasound or SonoAVC.


METHODS
The number of mature oocytes retrieved and clinical pregnancy rate.


RESULTS
The number of the mature oocytes collected (10.70 +/- 6.08 vs. 11.43 +/- 6.17), the number of fertilized oocytes (7.27 +/- 4.78 vs. 7.97 +/- 5.25), and the clinical pregnancy rates (42% vs. 43%) were similar with both 2D ultrasound and SonoAVC methods.


CONCLUSIONS
Automated follicle tracking using SonoAVC identifies a comparable number of follicles to real-time 2D ultrasound in this preliminary study. Timing final follicle maturation and egg retrieval on the basis of these automated measures does not appear to improve the clinical outcome of assisted reproduction treatment.
Raine-Fenning
Nick
N
Nottingham University Research and Treatment Unit in Reproduction, Division of Human Development, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom. nick.fenning@nottingham.ac.uk
Deb
Shilpa
S
Jayaprakasan
Kannamannadiar
K
Clewes
Jeanette
J
Hopkisson
James
J
Campbell
Bruce
B