title: Chiral Brønsted acid-catalyzed enantioselective three-component Povarov reaction.
abstract: The three-component Povarov reaction of aldehydes (2), anilines (3), and benzyl N-vinylcarbamate 4 in the presence of 0.1 equiv of chiral phosphoric acid 5 afforded cis-2,4-disubstituted tetrahydroquinolines (1) in good yields and excellent enantiomeric excesses. The shortest synthesis of torcetrapib reported to date, which features this key three-component reaction, is documented.
authors.affiliation: Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Hua
authors.initials: H
authors.lastname: Liu
authors.forename: Guillaume
authors.initials: G
authors.lastname: Dagousset
authors.forename: Géraldine
authors.initials: G
authors.lastname: Masson
authors.forename: Pascal
authors.initials: P
authors.lastname: Retailleau
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu