title: Timing of oocyte maturation and egg collection during controlled ovarian stimulation: a randomized controlled trial evaluating manual and automated measurements of follicle diameter.
abstract: OBJECTIVE
  To evaluate the effect of a new automated technique of follicle measurement (Sono automated volume calculation [SonoAVC]) on the timing of oocyte maturation and subsequent oocyte retrieval.
  
  
  METHODS
  Prospective randomized controlled trial.
  
  
  METHODS
  University-based Assisted Conception Unit.
  
  
  METHODS
  Seventy-two women undergoing their first cycle of assisted reproduction treatment.
  
  
  METHODS
  The timing of final follicle maturation and oocyte retrieval based on follicle tracking with use of either conventional two-dimensional (2D) ultrasound or SonoAVC.
  
  
  METHODS
  The number of mature oocytes retrieved and clinical pregnancy rate.
  
  
  RESULTS
  The number of the mature oocytes collected (10.70 +/- 6.08 vs. 11.43 +/- 6.17), the number of fertilized oocytes (7.27 +/- 4.78 vs. 7.97 +/- 5.25), and the clinical pregnancy rates (42% vs. 43%) were similar with both 2D ultrasound and SonoAVC methods.
  
  
  CONCLUSIONS
  Automated follicle tracking using SonoAVC identifies a comparable number of follicles to real-time 2D ultrasound in this preliminary study. Timing final follicle maturation and egg retrieval on the basis of these automated measures does not appear to improve the clinical outcome of assisted reproduction treatment.
authors.affiliation: Nottingham University Research and Treatment Unit in Reproduction, Division of Human Development, School of Clinical Sciences, University of Nottingham, Nottingham, United Kingdom. nick.fenning@nottingham.ac.uk
authors.forename: Nick
authors.initials: N
authors.lastname: Raine-Fenning
authors.forename: Shilpa
authors.initials: S
authors.lastname: Deb
authors.forename: Kannamannadiar
authors.initials: K
authors.lastname: Jayaprakasan
authors.forename: Jeanette
authors.initials: J
authors.lastname: Clewes
authors.forename: James
authors.initials: J
authors.lastname: Hopkisson
authors.forename: Bruce
authors.initials: B
authors.lastname: Campbell