Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese.
The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD.
Tan
E K
EK
Department of Neurology, Singapore General Hospital, National Neuroscience Institute, Singapore. gnrtek@sgh.com.sg
Lu
C S
CS
Peng
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R
Teo
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Wu-Chou
Y H
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Chen
R S
RS
Weng
Y H
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Chen
C M
CM
Fung
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Tan
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Zhang
Z J
ZJ
An
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Lee-Chen
G J
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Lee
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Fook-Chong
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Burgunder
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Wu
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Wu
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