title: Impact of female gender and transradial coronary stenting with maximal antiplatelet therapy on bleeding and ischemic outcomes.
abstract: BACKGROUND
  Female gender has been associated with poorer outcomes after percutaneous coronary intervention (PCI) and femoral approach. However, no data are available on the impact of gender and transradial PCI with maximal antiplatelet therapy on bleeding and ischemic outcomes.
  
  
  METHODS
  In the EArly discharge after Stenting of coronarY arteries (EASY) trial, 1,348 patients with acute coronary syndrome underwent transradial PCI. All patients were pretreated with aspirin and clopidogrel. After sheath insertion, 70 U/kg heparin was administered and a bolus of abciximab was given before first balloon inflation. Major adverse cardiac events including death, myocardial infarction, and target vessel revascularization; major bleeding; and local hematomas were evaluated at 30 days, 6 months, and 12 months.
  
  
  RESULTS
  Women (n = 298, 22%) were older, had more hypertension, more family history, and less previous PCI than men. Weight, baseline hemoglobin, and creatinine clearance were significantly lower in women. The number of dilated sites, complex lesions, and procedure duration was similar, but 5F sheath size was more frequent in women. Major adverse cardiac events remained similar at 30 days (3.4% vs 3.9%, P = .86), at 6 months (11.5% vs 7.8%, P = .06), and at 1 year (14.1% vs 12.6%) in both groups. There was no significant difference in the incidence of major bleeding between the 2 groups, but female gender was the only independent predictor of hematomas (odds ratio 4.40, 95% confidence interval 2.49-7.81, P < .0001).
  
  
  CONCLUSIONS
  Despite more comorbidities, female gender was not a predictor of adverse clinical outcomes after transradial PCI with maximal antiplatelet therapy. Still, female gender remained associated with a higher risk of local hematomas. Efforts should continue to identify modifiable factors to reduce procedural bleeding in women, regardless of the access site.
authors.affiliation: Laval Hospital, Québec Heart-Lung Institute, Canada.
authors.forename: Helena
authors.initials: H
authors.lastname: Tizón-Marcos
authors.forename: Olivier F
authors.initials: OF
authors.lastname: Bertrand
authors.forename: Josep
authors.initials: J
authors.lastname: Rodés-Cabau
authors.forename: Eric
authors.initials: E
authors.lastname: Larose
authors.forename: Valérie
authors.initials: V
authors.lastname: Gaudreault
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Bagur
authors.forename: Onil
authors.initials: O
authors.lastname: Gleeton
authors.forename: Javier
authors.initials: J
authors.lastname: Courtis
authors.forename: Louis
authors.initials: L
authors.lastname: Roy
authors.forename: Paul
authors.initials: P
authors.lastname: Poirier
authors.forename: Olivier
authors.initials: O
authors.lastname: Costerousse
authors.forename: Robert
authors.initials: R
authors.lastname: De Larochellière