title: TMPZnCl.LiCl: a new active selective base for the directed zincation of sensitive aromatics and heteroaromatics.
abstract: A wide range of polyfunctional aryl and heteroaryl zinc reagents were efficiently prepared in THF via direct zincation using TMPZnCl.LiCl, a new exceptionally mild and efficient base. Activated arenes and heteroarenes are metalated at room temperature. Remarkably, sensitive functions such as an aldehyde as well as a nitro group are tolerated, expanding significantly the scope of directed metalations.
authors.affiliation: Department Chemie & Biochemie, Ludwig-Maximilians-Universitat, Butenandtstrasse 5-13, 81377 Munchen, Germany.
authors.forename: Marc
authors.initials: M
authors.lastname: Mosrin
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel