title: Impact of pancreatic allograft function on 1-year survival rates after simultaneous pancreatic-renal transplant.
abstract: OBJECTIVE
  Simultaneous pancreatic-renal transplant is an effective treatment for insulin-dependent patients with chronic renal failure. We sought to identify the main influences on pancreatic and patient survival rates after simultaneous pancreas-kidney transplants.
  
  
  METHODS
  The 1-year patient and pancreas survival rates of 150 patients who had undergone simultaneous pancreas-kidney transplant were analyzed by the Cox proportional hazards regression model and the Kaplan-Meier method. Uni and multivariate analyses were performed in terms of transplant-, recipient-, and donor-related risk factors.
  
  
  RESULTS
  At 1 year, patient and pancreatic allograft survival rates were 82% and 76.7%, respectively. Delayed graft function in the kidney (P = .001, HR 5.41), acute kidney rejection (P = .016, HR 3.36), and intra-abdominal infection (P < .0001, HR 4.15) were the main factors related to 1-year patient survival. Pancreatic allograft survival at 1 year was related to intra-abdominal infection (P < .0001, OR 12.83), vascular thrombosis (P = .002, OR 40.55), acute kidney rejection (P = .027, OR 3.06), donor sodium greater than 155 mEq/L (P = .02, OR 3.27), and dopamine administration exceeding 7.6 microg/kg/min (P = .046, OR 2.85).
  
  
  CONCLUSIONS
  Delayed kidney allograft function and intra-abdominal infection had an important effect on both patient and pancreatic allograft survival rates.
authors.affiliation: Universidade Federal de Sao Paulo, Brazil. erikabr@uol.com.br
authors.forename: Erika B
authors.initials: EB
authors.lastname: Rangel
authors.forename: Claudio S
authors.initials: CS
authors.lastname: Melaragno
authors.forename: Adriano M
authors.initials: AM
authors.lastname: Gonzalez
authors.forename: Marcelo M
authors.initials: MM
authors.lastname: Linhares
authors.forename: Joao R
authors.initials: JR
authors.lastname: de Sa
authors.forename: Alcides
authors.initials: A
authors.lastname: Salzedas
authors.forename: Jose O
authors.initials: JO
authors.lastname: Medina-Pestana