title: An African perspective on Helicobacter pylori: prevalence of human infection, drug resistance, and alternative approaches to treatment.
abstract: Helicobacter pylori is a Gram-negative, micro-aerophilic, motile, curved rod that inhabits the gastric mucosa of the human stomach. It chronically infects thousands of millions of people world-wide, and is one of the most genetically diverse of bacterial species. Infection with the bacterium leads to chronic gastritis, peptic ulceration, gastric cancers and gastric mucosa-associated lymphoid-tissue (MALT) lymphoma. The prevalence of infection appears to be partly determined by geographical and socio-demographic factors, being higher in Africa than elsewhere. Current treatment, based on potent combinations that each consist of a proton-pump inhibitor and two antibiotics, is successful in 80%-90% of patients. Some undesirable side-effects, poor patient compliance and drug resistance are, however, associated with significant levels of treatment failure and with contra-indications for some patients. Antibiotic resistance in H. pylori is a growing global concern that merits the urgent attention of public-health authorities. Numerous pieces of clinical evidence have revealed that eradication of the organism from a patient results in improvement of gastritis and drastically decreases the frequency of relapse of gastric and duodenal ulcers. Natural products, including medicinal plants and honey, may offer useful alternatives in the treatment of H. pylori-related infections.
authors.affiliation: Microbial Pathogenicity and Molecular Epidemiology Research Group, Department of Biochemistry and Microbiology, Faculty of Science and Agriculture, University of Fort Hare, P.M.B. X1314, Alice 5700, South Africa.
authors.forename: N F
authors.initials: NF
authors.lastname: Tanih
authors.forename: C
authors.initials: C
authors.lastname: Dube
authors.forename: E
authors.initials: E
authors.lastname: Green
authors.forename: N
authors.initials: N
authors.lastname: Mkwetshana
authors.forename: A M
authors.initials: AM
authors.lastname: Clarke
authors.forename: L M
authors.initials: LM
authors.lastname: Ndip
authors.forename: R N
authors.initials: RN
authors.lastname: Ndip