Diagnosis and treatment of acquired aplastic anemia.
Acquired severe aplastic anemia can be treated successfully with either immunosuppressive therapy or bone marrow transplantation. Although immunosuppressive therapy can be readily administered to all patients, it is not a curative approach and is associated with a higher risk of clonal evolution than is transplantation, which yields rapid and long-lasting hematologic remission. This article reviews the key diagnostic and prognostic factors that influence the choice of therapy in patients with acquired aplastic anemia.
Bacigalupo
Andrea
A
Divisione di Ematologia e Trapianto di Midollo Osseo, Ospedale San Martino Largo, Rosanna Benzi 10, Genova 16132, Italy. andrea.bacigalupo@hsanmartino.it
Passweg
Jakob
J