Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations.
Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.
Nyberg
Lars
L
Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Sweden. Lars.Nyberg@diagrad.umu.se
Andersson
Micael
M
Forsgren
Lars
L
Jakobsson-Mo
Susanna
S
Larsson
Anne
A
Marklund
Petter
P
Nilsson
Lars-Göran
LG
Riklund
Katrine
K
Bäckman
Lars
L