title: Microbiological findings in secondary infection of severe acute pancreatitis: a retrospective clinical study.
abstract: OBJECTIVE
  The aim of our study was to evaluate the bacteriologic findings in secondary infection of severe acute pancreatitis (SAP) and the potential correlation with infection.
  
  
  METHODS
  Three hundred thirty-six patients with acute pancreatitis admitted to our department between January 1, 2000, and April 30, 2008, were recruited. All patients were treated with Chinese standard treatment. Of these 336 patients, 65 with infected necrosis were studied according to the clinical data.
  
  
  RESULTS
  Sixty-five (19.35%) of 336 patients had SAP with secondary infection; the time for secondary infection was diagnosed after a mean of 14 to 20 days. One hundred thirty-three strains were found in 65 patients with SAP with infection; culture-revealed organism infection included 85 gram-negative germs, 44 gram-positive germs, and 4 fungi. In the group without infection, 271 patients were managed conservatively, of which 16 patients (5.90%) died; in the other group, 61 (93.85%) of 65 patients were treated by operation and 15 patients (23.08%) died.
  
  
  CONCLUSIONS
  The predominant infections were gram-negative bacterium, gram-positive bacterium, and fungi concomitantly or consecutively. Most of the infected patients had polyinfection. There were many patients with hospital-acquired infection and opportunistic infection. Multiple factors affected the outcome.
authors.affiliation: Nankai Hospital, Nankai Clinical School, Tianjin Medical University, Tianjin, PR China. nctsui@126.com
authors.forename: Nai-chiang
authors.initials: NC
authors.lastname: Tsui
authors.forename: ErPeng
authors.initials: E
authors.lastname: Zhao
authors.forename: ZhongLian
authors.initials: Z
authors.lastname: Li
authors.forename: Bing
authors.initials: B
authors.lastname: Miao
authors.forename: YunFeng
authors.initials: Y
authors.lastname: Cui
authors.forename: YinFeng
authors.initials: Y
authors.lastname: Shen
authors.forename: PengFei
authors.initials: P
authors.lastname: Qu