A general palladium-catalyzed amination of aryl halides with ammonia.
A new robust palladium/phosphine catalyst system for the selective monoarylation of ammonia with different aryl bromides and chlorides has been developed. The active catalyst is formed in situ from [Pd(OAc)(2)] and air- and moisture-stable phosphines as easy-to-handle pre-catalysts. The productivity of the catalyst system is comparable to that of competitive Pd/phosphine systems; full conversion is achieved with most substrates with 1-2 mol % of Pd source and a fourfold excess of ligand (L).
Schulz
Thomas
T
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Strasse 29a, 18059 Rostock, Germany.
Torborg
Christian
C
Enthaler
Stephan
S
Schäffner
Benjamin
B
Dumrath
Andreas
A
Spannenberg
Anke
A
Neumann
Helfried
H
Börner
Armin
A
Beller
Matthias
M