Total synthesis of (-)-bitungolide F.
An efficient total synthesis of (-)-bitungolide F (6) in 17 steps and 20.1% yield is described herein. Key steps involve a Myers asymmetric alkylation to introduce the C6 methyl with proper stereochemistry, a Claisen-like cyclization to construct the alpha,beta-unsaturated delta-lactone and a Julia-Kocienski olefination to assemble the conjugated diene moiety.
Su
Yingpeng
Y
Department of Chemistry, State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
Xu
Yanfen
Y
Han
Junjie
J
Zheng
Jiyue
J
Qi
Jing
J
Jiang
Tuo
T
Pan
Xinfu
X
She
Xuegong
X