Thermal cyclization of nonconjugated aryl-yne-carbodiimide furnishing a dibenzonaphthyridine derivative.
The reagent-free C(2)-C(7) thermal cyclization of a nonconjugated aryl-yne-carbodiimide yielded a dibenzo[b,g][1,8]naphthyridine derivative, whose congeners are known to possess fascinating pharmacological properties. This is the first heteroaromatic compound prepared by the thermal cycloaromatization of "nonconjugated" aryl-ynes.
Kimura
Hidenori
H
The Institute of Scientific and Industrial Research, Osaka University, Ibaraki, Osaka, Japan. hidenori-kimura@ds-pharma.co.jp
Torikai
Kohei
K
Ueda
Ikuo
I