Genetic and temporal dynamics of human immunodeficiency virus type 1 CRF07_BC in Xinjiang, China.
To explore the temporal genetic variation of human immunodeficiency virus type 1 CRF07_BC and reconstruct its epidemic in Xinjiang, China, we studied 216 C2-V4 fragments of env genes sampled from 1996 to 2008. Phylogenetic analysis indicates that the viruses prevailing in Xinjiang form a large monophyletic cluster and may have originated from a common ancestor. The epidemic in Xinjiang was probably established around 1995 (95% confidence interval, 1994-1996). We noted an increased diversity of CRF07_BC over time, with a rapid evolutionary rate we estimated to be 8.3x10(-3) substitutions per site per year in the env gene. After 5-6 years of the epidemic (1997-2002), the transmission rate of CRF07_BC in Xinjiang slowed down, although CRF07_BC infection remained at a high prevalence.
Xin
Ruolei
R
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
He
Xiang
X
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
Xing
Hui
H
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
Sun
Feng
F
Center for Disease Control and Prevention of Yili, Yining 835000, PR China.
Ni
Mingjian
M
Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830000, PR China.
Zhang
Yuanzhi
Y
Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830000, PR China.
Meng
Zhefeng
Z
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
Feng
Yi
Y
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
Liu
Shengya
S
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
Wei
Jing
J
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
Shao
Yiming
Y
State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.