De novo malignancy after solid organ transplantation in children.
The aim of this study was to assess the prevalence of de novo malignancy after solid organ transplantation in childhood. A retrospective questionnaire-based survey was sent to 9 referral centers for pediatric organ transplantation in France. Among 1326 children who underwent solid organ transplantation since 1996, 80 (6%) presented with de novo malignancy posttransplantation during childhood: posttransplant lymphoproliferative disease was the most common (5% of pediatric recipients) comprising 80% of all tumors, with a disproportionately high prevalence among combined liver and small bowel recipients (18%). Various solid tumors were observed mainly among kidney recipients. No skin cancer was reported.
Debray
D
D
Department of Pediatric Hepatology, APHP-Hôpital Bicêtre, Le Kremlin-Bicêtre, France. dominique.debray@bct.aphp.fr
Baudouin
V
V
Lacaille
F
F
Charbit
M
M
Rivet
C
C
Harambat
J
J
Iserin
F
F
Di Filippo
S
S
Guyot
C
C