title: Concentrations of voriconazole in healthy and inflamed lung in rats.
abstract: By utilizing the microdialysis technique, we investigated the pharmacokinetic profile of voriconazole in the interstitium of the lungs and skeletal muscle tissue of rats after a single intravenous dose under healthy and inflammatory conditions. As expected, voriconazole penetrated excellently into the interstitium of tissues, and its levels were descriptively almost identical to free concentration-versus-time profiles in plasma.
authors.affiliation: Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. christian.joukhadar@jp-medical-research.com
authors.forename: Christian
authors.initials: C
authors.lastname: Joukhadar
authors.forename: Christiane
authors.initials: C
authors.lastname: Thallinger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Pöppl
authors.forename: Florian
authors.initials: F
authors.lastname: Kovar
authors.forename: Karl H
authors.initials: KH
authors.lastname: Konz
authors.forename: Samir M
authors.initials: SM
authors.lastname: Joukhadar
authors.forename: Friederike
authors.initials: F
authors.lastname: Traunmüller