title: Enantioselective Friedel-Crafts reactions in water using a DNA-based catalyst.
abstract: Taking the plunge: The first example of a Lewis acid catalyzed asymmetric Friedel-Crafts alkylation with olefins in water is described. By using loadings of a DNA-based copper catalyst as low as 0.15 mol %, good yields and excellent enantioselectivities were obtained in the reaction of alpha,beta-unsaturated 2-acyl imidazoles with heteroaromatic pi nucleophiles. dmbpy = 4,4'-dimethyl-2,2'-bipyridine.
authors.affiliation: Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Boersma
authors.forename: Ben L
authors.initials: BL
authors.lastname: Feringa
authors.forename: Gerard
authors.initials: G
authors.lastname: Roelfes