title: Novel aminopeptidase N inhibitors derived from antineoplaston AS2-5 (Part II).
abstract: As our ongoing work, a series of peptidomimetic L-iso-glutamine derivatives derived from antineoplaston AS2-5 scaffold were prepared and their APN/CD13 and MMP-2 inhibitory activities were evaluated hereby. The results displayed that these compounds exhibited selective inhibition against APN as compared with MMP-2, with IC(50) values in micromole range. Compounds A1 and A2 showed comparable APN inhibitory activities than the positive control bestatin.
authors.affiliation: School of Pharmaceutical Sciences, Shandong University, No. 44 WenhuaXi Road, Ji'nan, 250012, Shandong Province, PR China.
authors.forename: Xun
authors.initials: X
authors.lastname: Li
authors.forename: Yazhou
authors.initials: Y
authors.lastname: Wang
authors.forename: Jifeng
authors.initials: J
authors.lastname: Wu
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Li
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Wenfang
authors.initials: W
authors.lastname: Xu