title: Studies on synthesis and pharmacological activities of 1,2,4-triazolo[3,4-b]1,3,4-thiadiazoles and their dihydro analogues.
abstract: 4-Amino-5-substituted aryl-3-mercapto-1,2,4-triazoles are versatile synthons for constructing various biologically active heterocycles. Starting from 4-amino-5-substituted aryl-3-mercapto-1,2,4-triazole 3a-c, a series of new 3,5-disubstituted-1,2,4-triazolo-[3,4-b]1,3,4-thiadiazoles and their 5,6-dihydrotriazolothiadiazoles were prepared. The structures of all the newly synthesized compounds have been confirmed by elemental analysis, IR,( 1)H-NMR, (13)C-NMR, and mass spectra. The antimicrobial effects of the synthesized compounds were investigated using the paper disc method. Anti-inflammatory and analgesic activities of the synthesized compounds were assessed by carrageenan-induced rat paw oedema method and by Eddy's hot plate method, respectively. Some of the compounds exhibited promising antimicrobial activities as well as moderate to good anti-inflammatory activity and analgesic activity.
authors.affiliation: Acharya & B. M. Reddy College of Pharmacy, Department of Pharmaceutical Chemistry, Bangalore, Karnataka, India. vinmathew_mb@yahoo.co.uk
authors.forename: Vinod
authors.initials: V
authors.lastname: Mathew
authors.forename: Devasahayam
authors.initials: D
authors.lastname: Giles
authors.forename: Jathi
authors.initials: J
authors.lastname: Keshavayya
authors.forename: Vijaya P
authors.initials: VP
authors.lastname: Vaidya