title: [Cellular therapy in autoimmune disease].
abstract: In addition to natural thymus-derived regulatory T-cells (Tregs), peripherally-induced Tregs are of central importance in immune homeostasis. Homotypic interactions between activated effector T-cells and resting memory T-cells induced the generation of IL-10 and IFNgamma producing Tregs in vitro. This mechanism in Treg development allows new insights into T-cell vaccination, which has been employed in pilot trials of multiple sclerosis and rheumatoid arthritis with promising results.
authors.affiliation: Rheumaeinheit, Medizinische Poliklinik, Klinikum der Universität München, Pettenkoferstrasse 8a, Munich, Germany. katja.thuemmler@med.uni-muenchen.de
authors.forename: K
authors.initials: K
authors.lastname: Thümmler
authors.forename: A
authors.initials: A
authors.lastname: Ramming
authors.forename: H
authors.initials: H
authors.lastname: Schulze-Koops
authors.forename: A
authors.initials: A
authors.lastname: Skapenko