title: Structural antitumoral activity relationships of synthetic chalcones.
abstract: Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile.
authors.forename: Cesar
authors.initials: C
authors.lastname: Echeverria
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile.
authors.forename: Juan Francisco
authors.initials: JF
authors.lastname: Santibañez
authors.affiliation: Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile.
authors.forename: Oscar
authors.initials: O
authors.lastname: Donoso-Tauda
authors.affiliation: Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile.
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Escobar
authors.affiliation: Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile.
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Ramirez-Tagle