title: Facial metrics in children with corticotrophin-producing pituitary adenomas suggest abnormalities in midface development.
abstract: BACKGROUND
  Tumors of the hypothalamic-pituitary unit have been linked to genetic syndromes that are associated with midfacial abnormalities.
  
  
  OBJECTIVE
  We hypothesized that mutations of genes that affect the development of the face (and consequently of the anterior pituitary) may be present in children with ACTH-producing pituitary adenomas, and if this is true then facial measurements would be different from those predicted by parental features.
  
  
  METHODS
  We studied 20 children with corticotropinomas and a control group and their parents. All facial measurements were expressed according to standard deviation scores.
  
  
  RESULTS
  Significant differences were seen between the children with pituitary adenomas and their parents for vertical facial height measures: nasal length (p < 0.001), lower facial height (p < 0.03) and overall facial height (p < 0.01).
  
  
  CONCLUSIONS
  We conclude that some of the indices of midline craniofacial development, in particular those affecting the vertical axis, are different in children with corticotroph adenomas producing ACTH.
authors.affiliation: Pediatric Endocrinology Inter-Institute Training Program, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Margaret F
authors.initials: MF
authors.lastname: Keil
authors.forename: Constantine A
authors.initials: CA
authors.lastname: Stratakis