title: Psoriasis--a systemic inflammatory disorder: clinic, pathogenesis and therapeutic perspectives.
abstract: Psoriasis has seen a dramatic change in its perception by dermatologists as well as other medical specialties. Its well-recognized association with several other diseases makes a complete switch in its management necessary. This review summarizes current epidemiological data on the comorbidities of psoriasis. Subsequently, the evidence for insulin resistance as a cause for endothelial cell dysfunction with its relevant pathogenetic link to the development of cardiovascular comorbidity is discussed. Based on these novel insights, we propose a possible state-of-the-art approach towards comprehensive psoriasis management.
authors.affiliation: Department of Dermatology and Venereology, University of Frankfurt/Main, Frankfurt/Main, Germany. boehncke@em.uni-frankfurt.de
authors.forename: Wolf-Henning
authors.initials: WH
authors.lastname: Boehncke
authors.forename: Wolfram
authors.initials: W
authors.lastname: Sterry