Long-term small molecule and protein elution from TiO2 nanotubes.
In this study, TiO(2) nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO(2) nanotubes may be a promising candidate for a drug-eluting implant coating.
Peng
Lily
L
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158-2330, USA.
Mendelsohn
Adam D
AD
LaTempa
Thomas J
TJ
Yoriya
Sorachon
S
Grimes
Craig A
CA
Desai
Tejal A
TA