The involvement of the transcription factor Yin Yang 1 in cancer development and progression.
The Yin Yang 1 (YY1) transcription factor has a pivotal role in normal biological processes such as development, differentiation, replication and cell proliferation exerting its effects on a huge number of genes involved in these processes. Mechanisms of YY1 action are related to its ability to initiate, activate, or repress transcription depending upon the context in which it binds. The role of YY1 played in cancer has been recently explored. This article summarizes the most relevant studies focused on YY1 regulation and dwells on the way how its overexpression may affect the clinical behavior of several cancer types. Furthermore, the contribution of the upregulation of YY1 exerted in response to therapeutic-induced apoptosis is discussed.
Castellano
Giancarlo
G
Unit of Molecular Therapies, Department of Experimental Oncology, Fondazione IRCCS, Istituto Nazionale dei Tumori, Milan, Italy.
Torrisi
Elena
E
Ligresti
Giovanni
G
Malaponte
Grazia
G
Militello
Loredana
L
Russo
Alessia E
AE
McCubrey
James A
JA
Canevari
Silvana
S
Libra
Massimo
M