Copper-catalyzed direct C arylation of heterocycles with aryl bromides: discovery of fluorescent core frameworks.
A window of opportunity: A general copper-catalyzed C-H bond-activation path allows arylation of heterocycles with a wide range of aryl bromides (see scheme). The reaction shows excellent regioselectivity and exhibits good functional group tolerance. The 8-aryl xanthines exhibit fluorescence in a variety of solvents and show promise as reagents for biological imaging.
Zhao
Dongbing
D
Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
Wang
Wenhai
W
Yang
Fei
F
Lan
Jingbo
J
Yang
Li
L
Gao
Ge
G
You
Jingsong
J