Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer.
Protein patterns of 129 Helicobacter pylori strains isolated from Korean and Colombian patients suffering from duodenal ulcer or gastric cancer were analyzed by the high-throughput methodology SELDI-TOF-MS. Eighteen statistically significant candidate biomarkers discriminating between the two clinical outcomes were selected by using the Mann-Whitney test. Three biomarker proteins were purified and identified as a neutrophil-activating protein NapA (HU HPAG1_0821), a RNA-binding protein (HPAG1_0813), and a DNA-binding histone-like protein HU, respectively (jhp0228). These novel biomarkers can be used for development of diagnostic assays predicting the evolution to gastric cancer in H. pylori-infected patients.
Khoder
Ghalia
G
EA 4331 LITEC, Université de Poitiers, Poitiers, France.
Yamaoka
Yoshio
Y
Fauchère
Jean-Louis
JL
Burucoa
Christophe
C
Atanassov
Christo
C