[Afobazole influence on antinociceptive properties of morphine].
The effects of afobazole (1.0 and 10.0 mg/kg, i.p.) on the antinociceptive properties of morphine (3.0 mg/kg, i.p.) were studied in mice. It is shown that afobazole attenuates the analgesic action of morphine in the "hot plate" and "tail flick" tests. This effect was prevented by sigma 1 receptor antagonist haloperidol (2.0 mg/kg, i.p.). Data obtained suggested that a decrease in the morphine antinociceptive action by afobazole is related to its agonistic interaction with sigma 1 receptors at supraspinal and spinal levels.
Kolik
L G
LG
Zhukov
V N
VN
Seredenin
S B
SB