title: Loss of cellular polarity/cohesiveness in the invasive front of papillary thyroid carcinoma and periostin expression.
abstract: Loss of cellular polarity/cohesiveness and periostin expression are involved in the epithelial-mesenchymal transition in the epithelial malignancies. Their roles in papillary thyroid carcinoma were studied. There was a significant correlation between the loss of cellular polarity/cohesiveness in the invasive front and the up-regulation of periostin in tumors. Both of them were significantly correlated with extrathyroid invasion, pT and lymph node metastasis. Our results suggest that the loss of cellular polarity/cohesiveness is a useful parameter for predicting prognosis of patients with papillary thyroid carcinoma, and periostin could be a candidate gene for therapeutic targeting for the blockage of tumor invasion.
authors.affiliation: Department of Pathology and Pathophysiology, Shandong University School of Medicine, Jinan, PR China.
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Bai
authors.forename: Kennichi
authors.initials: K
authors.lastname: Kakudo
authors.forename: Misa
authors.initials: M
authors.lastname: Nakamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Ozaki
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Li
authors.forename: Zhiyan
authors.initials: Z
authors.lastname: Liu
authors.forename: Ichiro
authors.initials: I
authors.lastname: Mori
authors.forename: Akira
authors.initials: A
authors.lastname: Miyauchi
authors.forename: Gengyin
authors.initials: G
authors.lastname: Zhou