title: Osteoconductivity of hydrophilic microstructured titanium implants with phosphate ion chemistry.
abstract: This study investigated the surface characteristics and bone response of titanium implants produced by hydrothermal treatment using H(3)PO(4), and compared them with those of implants produced by commercial surface treatment methods - machining, acid etching, grit blasting, grit blasting/acid etching or spark anodization. The surface characteristics were evaluated by scanning electron microscopy, thin-film X-ray diffractometry, X-ray photoelectron spectroscopy, contact angle measurement and stylus profilometry. The osteoconductivity of experimental implants was evaluated by removal torque testing and histomorphometric analysis after 6 weeks of implantation in rabbit tibiae. Hydrothermal treatment with H(3)PO(4) and subsequent heat treatment produced a crystalline phosphate ion-incorporated oxide (titanium oxide phosphate hydrate, Ti(2)O(PO(4))(2)(H(2)O)(2); TiP) surface approximately 5microm in thickness, which had needle-like surface microstructures and superior wettability compared with the control surfaces. Significant increases in removal torque forces and bone-to-implant contact values were observed for TiP implants compared with those of the control implants (p<0.001). After thorough cleaning of the implants removed during the removal torque testing, a considerable quantity of attached bone was observed on the surfaces of the TiP implants.
authors.affiliation: Department of Metals, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Japan. jinwoo@knu.ac.kr
authors.forename: Jin-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Je-Hee
authors.initials: JH
authors.lastname: Jang
authors.forename: Chong Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Takao
authors.initials: T
authors.lastname: Hanawa