title: KHSV(-) EBV(-) post-transplant effusion lymphoma with plasmablastic features: variant of primary effusion lymphoma?
abstract: Primary effusion lymphoma (PEL) is a rare type of B-cell non-Hodgkin lymphoma (NHL), which predominantly occurs in HIV-infected individuals, and is pathogenetically linked with Kaposi sarcoma (KS)-associated herpes virus/human herpes virus-8 (KSHV/HHV-8) infection with or without evidence of Epstein-Barr virus (EBV) co-infection. Although uncommon, PELs have been reported in immunocompetent patients and recipients of solid organ allografts. Rare cases of KSHV(-) EBV(+) post-transplant effusion lymphomas resembling PEL have also been described, as have KSHV(-) EBV(-) effusion lymphomas, the latter including those arising in individuals with chronic liver disease. We report a unique KSHV(-) EBV(-) post-transplant effusion lymphoma associated with serum paraproteins, occurring in an HIV(-) individual, which had cytologic features and phenotype similar to PEL, and displayed a complex karyotype including isochromosome 12p and translocation t(8;22), resulting in rearrangement of c-MYC.
authors.affiliation: Department of Pathology, Columbia University Medical Center, New York Presbyterian Hospital, New York, New York, USA.
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Lambe
authors.forename: Darryl A
authors.initials: DA
authors.lastname: Oble
authors.forename: Subhadra V
authors.initials: SV
authors.lastname: Nandula
authors.forename: Deborah W
authors.initials: DW
authors.lastname: Sevilla
authors.forename: Adriana I
authors.initials: AI
authors.lastname: Colovai
authors.forename: Mahesh
authors.initials: M
authors.lastname: Mansukhani
authors.forename: Ajai
authors.initials: A
authors.lastname: Chari
authors.forename: Vundavalli V
authors.initials: VV
authors.lastname: Murty
authors.forename: Bachir
authors.initials: B
authors.lastname: Alobeid
authors.forename: Govind
authors.initials: G
authors.lastname: Bhagat