title: Transient leukemia.
abstract: A new born with a mongoloid slant, brachycephaly and low-set ears presented at birth with a total leucocyte count of 57 x 10(3)/microL and the differential leucocyte count revealed 70% of these to be blasts. The morphology of the blasts was not characteristic of myeloid and lymphoid lineage. Cytochemistry showed myeloperoxidase (MPO), Sudan Black B (SBB), periodic acid-Schiff (PAS) and non-specific esterase (NSE) negativity. Flowcytometry showed blasts that were positive for CD-33, CD-34 and CD-7. On second follow-up on the 10th day, the same picture persisted on morphology. On subsequent follow-up, the blasts disappeared. This was thus confirmed to be a case with transient leukemia with Downs syndrome.
authors.affiliation: Department of Haematology, All India Institute of Medical Sciences, New Delhi-110 029, India.
authors.forename: Hema
authors.initials: H
authors.lastname: Anand
authors.forename: Sameer
authors.initials: S
authors.lastname: Bakhshi
authors.forename: Renu
authors.initials: R
authors.lastname: Saxena