title: Quantitative hemodynamic studies in moyamoya disease: a review.
abstract: Moyamoya disease is characterized by a chronic stenoocclusive vasculopathy affecting the terminal internal carotid arteries. The clinical presentation and outcome of moyamoya disease remain varied based on angiographic studies alone, and much work has been done to study cerebral hemodynamics in this group of patients. The ability to measure cerebral blood flow (CBF) accurately continues to improve with time, and with it a better understanding of the pathophysiological mechanisms in patients with moyamoya disease. The main imaging techniques used to evaluate cerebral hemodynamics include PET, SPECT, xenon-enhanced CT, dynamic perfusion CT, MR imaging with dynamic susceptibility contrast and with arterial spin labeling, and Doppler ultrasonography. More invasive techniques include intraoperative ultrasonography. The authors review the current knowledge of CBF in this group of patients and the role each main quantitative method has played in evaluating them, both in the disease state and after surgical intervention.
authors.affiliation: Department of Neurosurgery, Stanford Stroke Center, Stanford, California, USA. marcolee@stanford.edu
authors.forename: Marco
authors.initials: M
authors.lastname: Lee
authors.forename: Greg
authors.initials: G
authors.lastname: Zaharchuk
authors.forename: Raphael
authors.initials: R
authors.lastname: Guzman
authors.forename: Achal
authors.initials: A
authors.lastname: Achrol
authors.forename: Teresa
authors.initials: T
authors.lastname: Bell-Stephens
authors.forename: Gary K
authors.initials: GK
authors.lastname: Steinberg