Sc(OTf)3-catalyzed conjugate allylation of alkylidene Meldrum's acids.
Alkylidene Meldrum's acids are allylated in a conjugate fashion by allyltin nucleophiles under mild Sc(OTf)(3)-catalyzed conditions. The addition is functional group tolerant and reactions with nonracemic alkylidenes are highly diastereoselective. Allylation of alkylidenes derived from alpha-ketoesters yield all-carbon quaternary stereocenters.
Dumas
Aaron M
AM
Department of Chemistry, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
Fillion
Eric
E