title: Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder.
abstract: In this preliminary study, 16 psychotropic-naïve pediatric patients with obsessive-compulsive disorder (OCD) were studied using magnetic resonance spectroscopy (MRS) and genotyped for six candidate polymorphisms in two glutamate system genes. A significant association was identified between the rs1019385 polymorphism of the glutamate receptor, ionotropic, N-methyl-d-aspartate 2B (GRIN2B) and decreased anterior cingulate cortex (ACC) glutamatergic concentration (Glx) but not with occipital Glx. These results suggest that GRIN2B may be associated with Glx in the ACC, a region consistently implicated in OCD.
authors.affiliation: Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada M5G 1X8. paul.arnold@sickkids.ca
authors.forename: Paul Daniel
authors.initials: PD
authors.lastname: Arnold
authors.forename: Frank P
authors.initials: FP
authors.lastname: Macmaster
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Richter
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Hanna
authors.forename: Tricia
authors.initials: T
authors.lastname: Sicard
authors.forename: Eliza
authors.initials: E
authors.lastname: Burroughs
authors.forename: Yousha
authors.initials: Y
authors.lastname: Mirza
authors.forename: Phillip C
authors.initials: PC
authors.lastname: Easter
authors.forename: Michelle
authors.initials: M
authors.lastname: Rose
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
authors.forename: David R
authors.initials: DR
authors.lastname: Rosenberg