Galectin-2 (LGALS2) 3279C/T polymorphism may be independently associated with diastolic blood pressure in patients with rheumatoid arthritis.
The galectin-2 (LGALS2) 3279 C/T single nucleotide polymorphism (SNP) has recently been associated with myocardial infarction (MI). Although hypertension, a very prevalent entity in rheumatoid arthritis (RA), is one of the greatest risk factors for MI, the possible association of LGALS2 3279 C/T and hypertension has not been investigated. We genotyped 386 RA patients, 272 hypertensives and 114 normotensives. Diastolic blood pressure (DBP) was significantly lower in TT compared to CC homozygotes (-4.11 mmHg, p = 0.044) even when adjusted for multiple confounders (-4.28 mmHg, p = 033). Further studies are required to replicate the potential association of LGALS2 3279 C/T with DBP, and examine whether this SNP could be used as a marker of increased risk for future cardiovascular events in RA populations.
Panoulas
Vasileios F
VF
Department of Rheumatology, Dudley Group of Hospitals NHS Trust, Russells Hall Hospital, West Midlands, UK. bpanoulas@googlemail.com
Douglas
Karen M J
KM
Smith
Jacqueline P
JP
Metsios
Georgios S
GS
Elisaf
Moses S
MS
Nightingale
Peter
P
Kitas
George D
GD