title: Could insertion of the particles that induce osteolysis be a new treatment option in heterotopic ossification?
abstract: Heterotopic ossification (HO) is the formation of the bone outside the skeletal system, it is a common complication of surgery or trauma. The abnormal deposition or precipitation of calcium phosphate in tissues may be massive and clinically significant sometimes. Severe ossification often reduce joint function and induce pain. Unfortunately, to date, there is no satisfactory treatment available yet. Nowadays, periprosthetic osteolysis induced by wear debris is the most widely accepted cause of aseptic loosening after total joint replacement. A large number of researches have identified metal particles can stimulate bone resorption by targeting osteoclasts. So it is hypothesized that the insertion of metal particles in the region surrounding heterotopic bone could be a new treatment option in HO.
authors.affiliation: Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Middle Ren-Min Road No. 139, Changsha, Hunan 410011, China. pingyuandoctor@yahoo.cn
authors.forename: Ping
authors.initials: P
authors.lastname: Yuan
authors.forename: Wan-Chun
authors.initials: WC
authors.lastname: Wang
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Li
authors.forename: Xin-Zhan
authors.initials: XZ
authors.lastname: Mao