Nipping fear in the bud: inhibitory control in the amygdala.
Cortical and thalamic inputs to the lateral amygdala are recruited during auditory fear conditioning. In this issue of Neuron, Pan et al. describe a new mechanism of GABA-mediated modulation at these synapses, involving target-specific suppression of glutamate release through differential activation of GABAb receptors on glutamatergic inputs to neurons and interneurons.
Bolshakov
Vadim Y
VY
Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA. vadimb@mclean.harvard.edu