Catalytic asymmetric oxa-Michael-Michael cascade for facile construction of chiral chromans via an aminal intermediate.
An unprecedented highly enantioselective cascade oxa-Michael-Michael reaction has been developed. The simple and practical process, efficiently catalyzed by chiral diphenylprolinol TMS ether, affords a powerful access to highly functionalized synthetically useful chiral chromans. Moreover, notably a new activation mode involving an aminal is disclosed for the first time.
Zu
Liansuo
L
Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, USA.
Zhang
Shilei
S
Xie
Hexin
H
Wang
Wei
W