title: The interaction of oxidative stress response with cytokines in the thyrotoxic rat: is there a link?
abstract: Oxidative stress is regarded as a pathogenic factor in hyperthyroidism. Our purpose was to determine the relationship between the oxidative stress and the inflammatory cytokines and to investigate how melatonin affects oxidative damage and cytokine response in thyrotoxic rats. Twenty-one rats were divided into three groups. Group A served as negative controls. Group B had untreated thyrotoxicosis, and Group C received melatonin. Serum malondialdehyde (MDA), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), and nitric oxide derivates (NO*x), and plasma IL-6, IL-10, and TNF-alpha were measured. MDA, GSH, NO*x, IL-10, and TNF-alpha levels increased after L-thyroxine induction. An inhibition of triiodothyronine and thyroxine was detected, as a result of melatonin administration. MDA, GSH, and NO*x levels were also affected by melatonin. Lowest TNF-alpha levels were observed in Group C. This study demonstrates that oxidative stress is related to cytokine response in the thyrotoxic rat. Melatonin treatment suppresses the hyperthyroidism-induced oxidative damage as well as TNF-alpha response.
authors.affiliation: Division of Pediatric Rheumatology and Immunology, Department of Pediatrics, School of Medicine, Dokuz Eylul University, 35340 Inciralti, Izmir, Turkey. balahan.bora@deu.edu.tr
authors.forename: Balahan
authors.initials: B
authors.lastname: Makay
authors.forename: Ozer
authors.initials: O
authors.lastname: Makay
authors.forename: Cigdem
authors.initials: C
authors.lastname: Yenisey
authors.forename: Gokhan
authors.initials: G
authors.lastname: Icoz
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozgen
authors.forename: Erbil
authors.initials: E
authors.lastname: Unsal
authors.forename: Mahir
authors.initials: M
authors.lastname: Akyildiz
authors.forename: Enis
authors.initials: E
authors.lastname: Yetkin