Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German Dementia Competence Network.
BACKGROUND
The German Dementia Competence Network (DCN) has established procedures for standardized multicenter acquisition of clinical, biological and imaging data, for centralized data management, and for the evaluation of new treatments.


METHODS
A longitudinal cohort study was set up for patients with mild cognitive impairment (MCI), patients with mild dementia and control subjects. The aims were to establish the diagnostic, differential diagnostic and prognostic power of a range of clinical, laboratory and imaging methods. Furthermore, 2 clinical trials were conducted with patients suffering from MCI and mild to moderate Alzheimer's Disease (AD). These trials aimed at evaluating the efficacy and safety of the combination of galantamine and memantine versus galantamine alone.


RESULTS
Here, we report on the scope and projects of the DCN, the methods that were employed, the composition and flow within the diverse groups of patients and control persons and on the clinical and neuropsychological baseline characteristics of the group of 2,113 subjects who participated in the observational and clinical trials.


CONCLUSIONS
These data have an impact on the procedures for the early and differential clinical diagnosis of dementias, the current standard treatment of AD as well as on future clinical trials in AD.
Kornhuber
Johannes
J
Department of Psychiatry and Psychotherapy, University Erlangen, Erlangen, Germany. Johannes.Kornhuber@uk-erlangen.de
Schmidtke
Klaus
K
Frolich
Lutz
L
Perneczky
Robert
R
Wolf
Stefanie
S
Hampel
Harald
H
Jessen
Frank
F
Heuser
Isabella
I
Peters
Oliver
O
Weih
Markus
M
Jahn
Holger
H
Luckhaus
Christian
C
Hüll
Michael
M
Gertz
Hermann-Josef
HJ
Schröder
Johannes
J
Pantel
Johannes
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Rienhoff
Otto
O
Seuchter
Susanne A
SA
Rüther
Eckart
E
Henn
Fritz
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Maier
Wolfgang
W
Wiltfang
Jens
J