title: Targeting major vault protein in senescence-associated apoptosis resistance.
abstract: BACKGROUND
  Recent studies have shown that major vault protein (MVP) is involved in intracellular signaling, cell survival, differentiation and innate immunity and that it is not directly responsible for nucleo-cytoplasmic drug transport in multi-drug-resistant cancer cell lines. Recently, we reported that MVP increases with age both in vitro and in vivo, and that age-related upregulation of MVP facilitates apoptosis resistance of senescent human diploid fibroblasts (HDFs) based on the interaction with c-Jun-mediated downregulation of bcl-2.
  
  
  OBJECTIVE
  To discuss the role of MVP in cell survival and signaling in the development of resistance to apoptosis exhibited by senescent HDFs.
  
  
  CONCLUSIONS
  MVP represents a versatile platform for regulation of cellular signaling and survival and is a potential therapeutic target for modulation of resistance to apoptosis, implicated in aging modulation and cancer treatment.
authors.affiliation: Department of Biochemistry and Molecular Biology, Seoul National University College of Medicine, Aging and Apoptosis Research Center, Seoul, South Korea.
authors.forename: Sung Jin
authors.initials: SJ
authors.lastname: Ryu
authors.forename: Sang Chul
authors.initials: SC
authors.lastname: Park