Hormones and drinking behaviour: new findings on ghrelin, insulin, leptin and volume-regulating hormones. An ESBRA Symposium report.
There is growing evidence for a role of appetite-related peptides and volume-regulating hormones in alcoholism. In particular, recent evidence has suggested that hormones, such as ghrelin, insulin and leptin and volume-regulating hormones, could play a role in alcohol-seeking behaviour. The goal of this review is to discuss the results of recent preclinical and clinical investigations on this topic. The findings indicate that neuroendocrinological mechanisms are potentially involved in the neurobiology of alcohol craving. Accordingly, research on this topic could lead to possible development of new therapeutic approaches in the treatment of patients with alcohol problems.
Addolorato
Giovanni
G
Institute of Internal Medicine, Catholic University of Rome, Largo A. Gemelli 8, Rome, Italy. g.addolorato@rm.unicatt.it
Leggio
Lorenzo
L
Hillemacher
Thomas
T
Kraus
Thomas
T
Jerlhag
Elisabet
E
Bleich
Stefan
S