title: Initial evaluation and follow-up of acute radiation syndrome in two patients from the Dakar accident.
abstract: The aim of this work was to evaluate and follow up the evolution of radiation damage in two victims of a radiation accident. Blood samples were used for cytogenetic evaluation of radiation dose and heterogeneity. The radiation dose estimates were 1 Gy and 2.3 Gy in the two most exposed patients. Plasma was used for the measurement of the Flt3 ligand as a marker of haematopoietic aplasia, citrulline for damage to the jejunal mucosal epithelium and oxysterols for damage to the liver, the central nervous system and the vascular compartment. The use of these biological indicators demonstrated the presence of a haematopoietic syndrome and suggested the presence of subclinical radiation-induced damage to the liver in one of the two patients. These results support the interest in using these biological indicators in order to evaluate radiation damage, especially in complex accidental situations.
authors.affiliation: Institut de Radioprotection et de Surete Nucleaire, DRPH/SRBE, Fontenay aux Roses, France. jean-marc.bertho@irsn.fr
authors.forename: Jean Marc
authors.initials: JM
authors.lastname: Bertho
authors.forename: Laurence
authors.initials: L
authors.lastname: Roy
authors.forename: Maâmar
authors.initials: M
authors.lastname: Souidi
authors.forename: Marc
authors.initials: M
authors.lastname: Benderitter
authors.forename: Eric
authors.initials: E
authors.lastname: Bey
authors.forename: Radjini
authors.initials: R
authors.lastname: Racine
authors.forename: Thierry
authors.initials: T
authors.lastname: Fagot
authors.forename: Patrick
authors.initials: P
authors.lastname: Gourmelon