title: Use of urokinase in percutaneous drainage of large breast abscesses.
abstract: OBJECTIVE
  The purpose of this study was to evaluate intracavitary urokinase therapy versus irrigation with a saline solution in percutaneous drainage of large breast abscesses.
  
  
  METHODS
  A prospective randomized study was conducted in 19 nonlactating women (median age, 35.7 years) with breast abscesses of greater than 3 cm. Percutaneous drainage with an ultrasound-guided catheter was performed in group A patients (saline solution) and group B patients (urokinase). Postdrainage care and ultrasound-guided drainage control were performed on an outpatient basis. The Student t test, Fisher exact test, chi(2) test, and Mann-Whitney U test were used for statistical analysis.
  
  
  RESULTS
  Percutaneous drainage with saline or urokinase irrigation was successful in all cases. No statistically significant differences were observed between groups A and B for clinical parameters and sonographic characteristics of the abscesses. However, a statistically significant difference was observed between the two groups for the average drainage times (P < 0.012), which were 3.8 days for the urokinase group and 5.3 days for the saline group. A recurrence was observed in 1 saline group patient who had a diagnosis of a chronic abscess, which was resolved with intracavitary urokinase irrigation.
  
  
  CONCLUSIONS
  Percutaneous drainage of large breast abscesses in nonlactating women with intracavitary urokinase irrigation is a simple and safe procedure. It reduces the treatment time and improves the clinical course of patients more than conventional drainage with saline irrigation.
authors.affiliation: Department of Radiology, Virgen de la Arrixaca University Hospital, 30120 El Palmar (Murcia), Spain. jdberna@um.es
authors.forename: Juan D
authors.initials: JD
authors.lastname: Berná-Serna
authors.forename: Juan D
authors.initials: JD
authors.lastname: Berná-Mestre
authors.forename: Pedro J
authors.initials: PJ
authors.lastname: Galindo
authors.forename: Manuel
authors.initials: M
authors.lastname: Madrigal