Prospective, sequential, longitudinal study of coagulation changes during pregnancy in Chinese women.
OBJECTIVE
To investigate changes and establish reference values for coagulation variables during normal pregnancy and after delivery in Chinese women.


METHODS
A prospective, sequential, longitudinal study with strict inclusion and exclusion criteria was performed with 232 Chinese women.


RESULTS
Prothrombin time, international normalized ratio, activated partial thromboplastin time, and activated partial thromboplastin time ratio were shorter, and platelet count decreased gradually during pregnancy, with no change in mean platelet volume; conversely, plasma concentration of both fibrinogen and fibrin/fibrinogen degradation product increased. All these variables were normalized during the postpartum. Reference values by gestational week were established for platelet count, fibrinogen concentration, and fibrin/fibrinogen degradation product concentration.


CONCLUSIONS
These reference values may be used in the health assessment of pregnant women with a similar socioeconomic and ethnic background.
Liu
Xing-hui
XH
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China.
Jiang
Yong-mei
YM
Shi
Hua
H
Yue
Xin-ai
XA
Wang
Yue-fang
YF
Yang
Hui
H