title: Fatty acid synthase inhibitors from Geum japonicum Thunb. var. chinense.
abstract: Bioassay-guided fractionation of the MeOH extract of Geum japonicum Thunb. var. chinense using the fatty acid synthase inhibition assay led to the isolation of a new dimeric ellagitannin, gemin G (1), together with six known compounds, gemin A (2), casuarinin (3), pedunculagin (4), potentillin (5) , tellimagrandin II (6), and ellagic acid (7). Their structures were determined on the basis of spectroscopic analyses. Compounds 1-7 displayed strong inhibitory activities on fatty acid synthase with IC(50) values in the range of 0.21-41.4 microM. Compounds 1-4 exhibited significant antioxidant activities higher than vitamin C in the ORAC assay. Compounds 1 and 2 also showed weak cytotoxic effects on BGC-823 cell.
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, No. 8 Zhongguancun Beiertiao Road, Haidian District, Beijing, P. R. China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.forename: Jiankuan
authors.initials: J
authors.lastname: Li
authors.forename: Wenhua
authors.initials: W
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Bao
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Song
authors.forename: Ying
authors.initials: Y
authors.lastname: Xia
authors.forename: Xue
authors.initials: X
authors.lastname: Wang
authors.forename: Chao
authors.initials: C
authors.lastname: Zhang
authors.forename: Xiaozhu
authors.initials: X
authors.lastname: Wang
authors.forename: Xinsheng
authors.initials: X
authors.lastname: Yao
authors.forename: Ming
authors.initials: M
authors.lastname: Li