title: Acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.
abstract: OBJECTIVE
  Coffee consumption has been associated with lower risk of type 2 diabetes. We evaluated the acute effects of decaffeinated coffee and the major coffee components chlorogenic acid and trigonelline on glucose tolerance.
  
  
  METHODS
  We conducted a randomized crossover trial of the effects of 12 g decaffeinated coffee, 1 g chlorogenic acid, 500 mg trigonelline, and placebo (1 g mannitol) on glucose and insulin concentrations during a 2-h oral glucose tolerance test (OGTT) in 15 overweight men.
  
  
  RESULTS
  Chlorogenic acid and trigonelline ingestion significantly reduced glucose (-0.7 mmol/l, P = 0.007, and -0.5 mmol/l, P = 0.024, respectively) and insulin (-73 pmol/l, P = 0.038, and -117 pmol/l, P = 0.007) concentrations 15 min following an OGTT compared with placebo. None of the treatments affected insulin or glucose area under the curve values during the OGTT compared with placebo.
  
  
  CONCLUSIONS
  Chlorogenic acid and trigonelline reduced early glucose and insulin responses during an OGTT.
authors.affiliation: Department of Health Sciences, EMGO Institute for Health and Care Research, VU University Amsterdam, the Netherlands.
authors.forename: Aimée E
authors.initials: AE
authors.lastname: van Dijk
authors.forename: Margreet R
authors.initials: MR
authors.lastname: Olthof
authors.forename: Joke C
authors.initials: JC
authors.lastname: Meeuse
authors.forename: Elin
authors.initials: E
authors.lastname: Seebus
authors.forename: Rob J
authors.initials: RJ
authors.lastname: Heine
authors.forename: Rob M
authors.initials: RM
authors.lastname: van Dam