title: Composite lymphoma with relapse of enteropathy-type T-cell lymphoma.
abstract: We describe an unusual case of with de novo composite diffuse large B-cell lymphoma and enteropathy-type T-cell lymphoma involving the duodenum in a 65-year-old man with celiac disease. A segmental duodenum resection revealed that two neoplastic components had infiltrated the intestinal wall. The coexistence of two malignancies was confirmed by immunohistochemical and molecular biologic analysis, which revealed clonal T-cell receptor gamma and immunoglobulin heavy chain gene rearrangements. Epstein-Barr virus was not detected in the B- and T-cell components. After chemotherapy, the patient experienced two relapses of enteropathy-type T-cell lymphoma only. We review the medical literature on composite B- and T-cell lymphomas and discuss their diagnosis, pathogenesis, prognosis and treatment.
authors.affiliation: Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.
authors.forename: Zunguo
authors.initials: Z
authors.lastname: Du
authors.forename: Jieqing
authors.initials: J
authors.lastname: Chen
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Zhou
authors.forename: Taiming
authors.initials: T
authors.lastname: Zhang
authors.forename: Bobin
authors.initials: B
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Tang