title: Efficacy of low-dose hydrochlorothiazide in combination with telmisartan on early morning blood pressure in uncontrolled hypertensive patients.
abstract: Hypertensive patients whose BP was uncontrolled despite the use of antihypertensive agents, including an ARB (candesartan 8 mg/day or valsartan 80 mg/day), were enrolled. The patients were randomly assigned to combination therapy with telmisartan 40 mg/day (changed from current ARB) and hydrochlorothiazide (HCTZ) 12.5 mg/day (T + H, n = 32) or to no change in their current drug regimen (CTL, n = 32). The observation period was 12 weeks. The office and home BPs were significantly reduced in the T + H compared to those in the CTL. A sufficient and long-acting BP lowering effect, as reflected in decreased early morning BP, was obtained with the combination of low-dose HCTZ and telmisartan without apparent metabolic deterioration.
authors.affiliation: Department of Internal Medicine, Unit of Cardiology and Memorial Heart Center, Iwate Medical University School of Medicine, Uchimaru, Morioka, Japan. makitas@seagreen.ocn.ne.jp
authors.forename: Shinji
authors.initials: S
authors.lastname: Makita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Abiko
authors.forename: Yujirou
authors.initials: Y
authors.lastname: Naganuma
authors.forename: Makiko
authors.initials: M
authors.lastname: Tamada
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Nakamura