[Specific effects of selective anxiolytic afobazole on the cardiovascular system].
Experiments in narcotized rats showed the new selective anxiolytic afobazole, a derivative of 2-mercaptobenzimidazole, to cause a small bradycardia with almost no effect on the important parameters of heart hemodynamics and cardiac performance such as the arterial pressure, cardiac output, and mean aorta blood flow acceleration. Afobazole decreased the rate of ventricular fibrillations during 7-min occlusion followed by 3-min reperfusion of the left coronary artery in narcotized rats. Afobazole administered in rats for 21 days under conditions of experimental myocardial infarction had no effect on the pump and contractile cardiac functions. The drug normalized the reaction of mean aorta blood flow acceleration to the volume load suppressed by myocardial infarction, which was indicative of an increase in the adaptive capacity of myocardium.
Tsorin
I B
IB
Palka
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IP
Chichkanov
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GG