Conferols A and B, new anti-inflammatory 4-hydroxyisoflavones from Caragana conferta.
Conferols A (1) and B (2), the new 4-hydroxyisoflavones, have been isolated from the dichloromethane sub-fraction of the methanolic extract of Caragana conferta along with 3',5'-dihydroxy, 7,4'-dimethoxyisoflavone (3), E-cinnamic acid (4), tetracosyl 3,4-dihydroxy-E-cinnamate (5), docosyl 3,4-dihydroxy-E-cinnamate (6), beta-sitosterol (7), beta-sitostrerol 3-O-beta-D-glucopyranoside (8), stigmasterol (9) and lupeol (10), respectively, reported for the first time from this species. The structures of the new compounds were elucidated through spectroscopic techniques including MS and 2D-NMR. The compounds 1-3 showed significant anti-inflammatory activity in the respiratory burst assay.
Khan
Rehan
R
International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
Malik
Abdul
A
Adhikari
Achyut
A
Qadir
Mohammad Irfan
MI
Choudhary
Muhammad Iqbal
MI