title: Ligustrazine derivatives. Part 3: Design, synthesis and evaluation of novel acylpiperazinyl derivatives as potential cerebrocardiac vascular agents.
abstract: A series of novel acylpiperazinyl Ligustrazine derivatives was designed, synthesized, and their protective effects on damaged ECV-304 cells and antiplatelet aggregation activities were evaluated. The results showed that compound E33 displayed most potential protective effects on the ECV-304 cells damaged by hydrogen peroxide, and compound E1 was found to be the most active antiplatelet aggregation agent. Structure-activity relationships were briefly discussed.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhuaxi Road, Jinan 250012, China.
authors.forename: Xian-Chao
authors.initials: XC
authors.lastname: Cheng
authors.forename: Xin-Yong
authors.initials: XY
authors.lastname: Liu
authors.forename: Wen-Fang
authors.initials: WF
authors.lastname: Xu
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Guo
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Yu-Ning
authors.initials: YN
authors.lastname: Song