title: Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes).
abstract: Pharmaceutical and personal care products (PPCPs) enter aquatic environments via sewage treatment facilities and their potentially toxic effects on biota, particularly aquatic organisms, are of considerable concern. In this study, we investigated the acute toxicity of selected PPCPs on a freshwater crustacean (Thamnocephalus platyurus) and a fish species (Oryzias latipes). The 24-hr median lethal concentration (LC(50)) values of ibuprofen, mefenamic acid, indometacin, carbamazepine, propranolol, ifenprodil, clarithromycin and triclosan for T. platyurus were estimated to be 19.59, 3.95, 16.14, > 100, 10.31, 4.43, 94.23 and 0.47 mg/l respectively. Conversely, the 96-hr LC(50) values for these PPCPs were estimated at > 100, 8.04, 81.92, 45.87, 11.40, 8.71, > 100 and 0.60 mg/l for O. latipes, respectively. The toxic sensitivity of T. platyurus to these PPCPs, except for carbamazepine, was therefore higher than for O. latipes. No acute toxicity effects were associated with PPCPs, such as atenolol, disopyramide, famotidine, fluconazole, erythromycin and levofloxacin, in the two aquatic organisms at the concentrations tested in this study (> 100 mg/l). These findings may help us to understand the potential biological effects and risks associated with PPCP exposure in aquatic organisms. Further long-term studies are required to fully assess the growth and reproduction of these compounds on aquatic biota.
authors.forename: Joon-Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Ryoko
authors.initials: R
authors.lastname: Yamauchi
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Ichikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Takao
authors.forename: Masashi
authors.initials: M
authors.lastname: Hirano
authors.forename: Minoru
authors.initials: M
authors.lastname: Koga
authors.forename: Koji
authors.initials: K
authors.lastname: Arizono