Absence of deleterious palladin mutations in patients with familial pancreatic cancer.
It has been reported that germline mutations in the palladin gene (PALLD) cause the familial aggregation of pancreatic cancer, but the evidence is weak and controversial. We sequenced the coding regions of PALLD in 48 individuals with familial pancreatic cancer. We did not find any deleterious mutations and find no evidence to implicate mutations in PALLD as a cause of familial pancreatic cancer.
Klein
Alison P
AP
Department of Pathology, The John Hopkins University School of Medicine, Baltimore, MD, USA.
Borges
Michael
M
Griffith
Margaret
M
Brune
Kieran
K
Hong
Seung-Mo
SM
Omura
Noriyuki
N
Hruban
Ralph H
RH
Goggins
Michael
M