Allergic women have reduced sHLA-G plasma levels at delivery.
OBJECTIVE
HLA-G antigen maintains a tolerogenic condition at the foeto-maternal interface, counteracts inflammation in autoimmune diseases and soluble HLA-G (sHLA-G) levels decrease in allergic-asthmatics. Taking into consideration these findings, we analyzed if sHLA-G and interleukin-10 (IL-10) could be influenced by pregnancy and labour in allergic and non-allergic women.


METHODS
sHLA-G isoforms and IL-10 levels were determined in the plasma samples of 43 women (15 non-allergic, 28 allergic) during third trimester, at delivery and 2 years after pregnancy by immunoenzymatic assays.


RESULTS
A significant increase in sHLA-G and IL-10 levels was documented at delivery in both allergic and non-allergic women. Allergic women showed lower sHLA-G concentrations. sHLA-G1 was evidenced as the predominant plasma isoform.


CONCLUSIONS
The data showed increased sHLA-G and IL-10 concentrations at delivery, regardless of the allergic status. The sHLA-G1 isoform is mainly responsible for the increased sHLA-G levels at delivery.
Rizzo
Roberta
R
Department of Experimental and Diagnostic Medicine, Laboratory of Immunogenetics, University of Ferrara, Via Luigi Borsari 46, Ferrara, Italy. rbr@unife.it
Stignani
Marina
M
Amoudruz
Petra
P
Nilsson
Caroline
C
Melchiorri
Loredana
L
Baricordi
Olavio
O
Sverremark-Ekström
Eva
E