Concise enantioselective synthesis of ent-malbrancheamide B.
A concise enantioselective synthesis of the fungal metabolite ent-malbrancheamide B was accomplished through the union of a C-prenylated proline derivative and a substituted indole pyruvic acid SEM enol ether, followed by a cationic double cyclization as the key step.
Frebault
Frederic
F
School of Chemistry, The University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Simpkins
Nigel S
NS
Fenwick
Ashley
A