A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes.
In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.
Chamorro
Cristina
C
Medicinal Chemistry & Chemical Biology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, NL-3508 TB, Utrecht, The Netherlands.
Kruijtzer
John A W
JA
Farsaraki
Marina
M
Balzarini
Jan
J
Liskamp
Rob M J
RM