title: PD-1 on dendritic cells impedes innate immunity against bacterial infection.
abstract: Programmed death one (PD-1) is an inducible molecule belonging to the immunoglobulin superfamily. It is expressed on activated T and B lymphocytes and plays pivotal roles in the negative regulation of adaptive immune responses. We report here an unexpected finding: that PD-1 could also be induced on splenic dendritic cells (DCs) by various inflammatory stimuli. Adoptive transfer of PD-1-deficient DCs demonstrates their superior capacity to wild-type DCs in innate protection of mice against lethal infection by Listeria monocytogenes. Furthermore, PD-1-deficient mice are also more resistant to the infection than wild-type controls, even in the absence of T and B cells, accompanied by elevated production of DC-derived interleukin-12 and tumor necrosis factor-alpha. Our results reveal a novel role of PD-1 in the negative regulation of DC function during innate immune response.
authors.affiliation: Department of Oncology and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
authors.forename: Sheng
authors.initials: S
authors.lastname: Yao
authors.forename: Shengdian
authors.initials: S
authors.lastname: Wang
authors.forename: Yuwen
authors.initials: Y
authors.lastname: Zhu
authors.forename: Liqun
authors.initials: L
authors.lastname: Luo
authors.forename: Gefeng
authors.initials: G
authors.lastname: Zhu
authors.forename: Sarah
authors.initials: S
authors.lastname: Flies
authors.forename: Haiying
authors.initials: H
authors.lastname: Xu
authors.forename: William
authors.initials: W
authors.lastname: Ruff
authors.forename: Megan
authors.initials: M
authors.lastname: Broadwater
authors.forename: In-Hak
authors.initials: IH
authors.lastname: Choi
authors.forename: Koji
authors.initials: K
authors.lastname: Tamada
authors.forename: Lieping
authors.initials: L
authors.lastname: Chen