title: Genetic and temporal dynamics of human immunodeficiency virus type 1 CRF07_BC in Xinjiang, China.
abstract: To explore the temporal genetic variation of human immunodeficiency virus type 1 CRF07_BC and reconstruct its epidemic in Xinjiang, China, we studied 216 C2-V4 fragments of env genes sampled from 1996 to 2008. Phylogenetic analysis indicates that the viruses prevailing in Xinjiang form a large monophyletic cluster and may have originated from a common ancestor. The epidemic in Xinjiang was probably established around 1995 (95% confidence interval, 1994-1996). We noted an increased diversity of CRF07_BC over time, with a rapid evolutionary rate we estimated to be 8.3x10(-3) substitutions per site per year in the env gene. After 5-6 years of the epidemic (1997-2002), the transmission rate of CRF07_BC in Xinjiang slowed down, although CRF07_BC infection remained at a high prevalence.
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Ruolei
authors.initials: R
authors.lastname: Xin
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: He
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Xing
authors.affiliation: Center for Disease Control and Prevention of Yili, Yining 835000, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.affiliation: Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830000, PR China.
authors.forename: Mingjian
authors.initials: M
authors.lastname: Ni
authors.affiliation: Center for Disease Control and Prevention of Xinjiang Uygur Autonomous Region, Urumqi 830000, PR China.
authors.forename: Yuanzhi
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Zhefeng
authors.initials: Z
authors.lastname: Meng
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Feng
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Shengya
authors.initials: S
authors.lastname: Liu
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wei
authors.affiliation: State Key Laboratory for Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, China CDC, Beijing 100050, PR China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Shao