Structural antitumoral activity relationships of synthetic chalcones.
Relationships between the structural characteristic of synthetic chalcones and their antitumoral activity were studied. Treatment of HepG2 cells for 24 h with synthetic 2'-hydroxychalcones resulted in apoptosis induction and dose-dependent inhibition of cell proliferation. The calculated reactivity indexes and the adiabatic electron affinities using the DFT method including solvent effects, suggest a structure-activity relationship between the Chalcones structure and the apoptosis in HepG2 cells. The absence of methoxy substituents in the B ring of synthetic 2'-hydroxychalcones, showed the mayor structure-activity pattern along the series.
Echeverria
Cesar
C
Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile.
Santibañez
Juan Francisco
JF
Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, El Líbano 5524, Macul, Santiago, Chile.
Donoso-Tauda
Oscar
O
Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile.
Escobar
Carlos A
CA
Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile.
Ramirez-Tagle
Rodrigo
R
Universidad Andres Bello, Departamento de Ciencias Químicas, Av. República 275, Santiago, Chile.