title: [Effect of neuronal differentiation induced by nerve growth factor on the tolerance-dosage of ultraviolet radiation of PC12 cells].
abstract: OBJECTIVE
  To evaluate the effect of neuronal differentiation induced by nerve growth factor (NGF) on the tolerance-dosage of ultraviolet radiation of PC12 Cells.
  
  
  METHODS
  Neuron-differentiated PC12 cells and untreated PC12 cells were exposed to different ultraviolet radiation dosage of 10, 30, 60, 80, 100, and 200 mJ/cm2. Cell survival rates were determined by MTT assay.
  
  
  RESULTS
  Neuron-differentiated PC12 cells had increased tolerance dose to ultraviolet radiation with noticeable apoptosis at the radiation dose of 100 mJ/cm2 in contrast to 30 mJ/cm2 for normal PC12 cells.
  
  
  CONCLUSIONS
  Neuronal differentiation exerts the effect of increasing the tolerance dose of PC12 cells to ultraviolet radiation.
authors.affiliation: Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Dan-Hui
authors.initials: DH
authors.lastname: Li
authors.forename: Hao-Xiang
authors.initials: HX
authors.lastname: Xu
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.forename: Ya-Gang
authors.initials: YG
authors.lastname: Zuo
authors.forename: Xiang-Hong
authors.initials: XH
authors.lastname: Yan