Anti-inflammatory modalities: their current use in pediatric cardiac surgery in the United Kingdom and Ireland.
OBJECTIVE
To determine the use of anti-inflammatory therapies in infants and children undergoing cardiac surgery in the United Kingdom and Ireland.


METHODS
Questionnaire survey.


METHODS
All centers that undertake pediatric cardiac surgery in the United Kingdom and Ireland.


RESULTS
All centers use at least one anti-inflammatory therapy, with 46% of centers using more than one. Both modified ultrafiltration (80%) and steroids (80%) are widely used as anti-inflammatory strategies. Among centers that use steroids, dose, preparation, and timing of steroid administered was highly variable. Heparin-bonded circuits and aprotinin are infrequently used as anti-inflammatory techniques.


CONCLUSIONS
Although anti-inflammatory interventions are believed to contribute to improved patient outcome following cardiopulmonary bypass, this survey has shown that there are still widespread variations in practice. Rather than reflecting poor clinical practice, we believe this reflects a lack of good evidence supporting clinical benefit.
Allen
Meredith
M
Royal Brompton Hospital-Pediatric Intensive Care, London, United Kingdom. m.allen@rbht.nhs.uk
Sundararajan
Santosh
S
Pathan
Nazima
N
Burmester
Margarita
M
Macrae
Duncan
D