title: [Fulvestrant in heavily pretreated postmenopausal women with advanced breast cancer].
abstract: OBJECTIVE
  Fulvestrant (Flv) is a pure antiestrogen without agonist activity. Flv is effective as second line treatment in postmenopausal women with advanced breast cancer after tamoxifen.
  
  
  METHODS
  We performed a retrospective study of 36 consecutive postmenopausal women treated with Flv and advanced breast cancer progressing on prior therapies. 62,8% received Flv as third line treatment or more (all patients had previously received endocrine treatment for early or advanced breast cancer), 54,3% adjuvant chemotherapy and 67,5% received chemotherapy for metastatic disease. Our objective was to analyze the response rate, clinical benefit, time to progression (TTP) and toxicity profile.
  
  
  RESULTS
  In our study 11,4% patients had partial responses (PR) and 22,9% had a stable disease (SD) >24 weeks. Clinical benefit rate (CB) [RP+RC+SD]: 31,4%. TTP: 4,2 months (CI 95%, 2,6-5,8), with a median follow-up of 8,9 months. Flv was well tolerated, 22,9% patients had adverse events, all grade I/II, and only 5,7% of women gave up the treatment.
  
  
  CONCLUSIONS
  These data demonstrate that Flv is an effective and safe therapy for heavily pre-treated postmenopausal women with advanced breast cancer.
authors.affiliation: Hospital General Universitario Gregorio Marañón, Madrid, España. virgimarin9@hotmail.com
authors.forename: Virginia
authors.initials: V
authors.lastname: Martínez Marín
authors.forename: Andrés J
authors.initials: AJ
authors.lastname: Muñoz Martín
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Viñuela Benéitez
authors.forename: Pilar
authors.initials: P
authors.lastname: García Alfonso
authors.forename: Antonio
authors.initials: A
authors.lastname: Alonso Muñoz
authors.forename: Gumersindo
authors.initials: G
authors.lastname: Pérez Manga