title: Effects of a new PAR1 antagonist, F 16618, on smooth muscle cell contraction.
abstract: This study evaluated the effects of two PAR1 antagonists on vessels contracted by SFLLR. ER 121958 antagonized the SFLLR-induced contraction on rat denuded superior mesenteric artery and pig coronary artery in a non-competitive manner (IC(50) values were 22 [7.5-43.6] nM and 2.9 [2.09-4.02] nM, respectively). F 16618 inhibited the SFLLR-induced superior mesenteric arteries and coronary arteries contraction in a competitive manner (pA(2) values of 7.3 and 6.2, respectively). PAR1 antagonists do not affect vessel resting tension or haemodynamic parameters in anaesthetized rats. Thus, PAR1 antagonists could have beneficial effects against vasospasm due to vessel injury.
authors.affiliation: Centre de Recherche Pierre Fabre, Castres Cedex, France.
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bocquet
authors.forename: Robert
authors.initials: R
authors.lastname: Létienne
authors.forename: Sylvie
authors.initials: S
authors.lastname: Sablayrolles
authors.forename: Luc
authors.initials: L
authors.lastname: De Vries
authors.forename: Michel
authors.initials: M
authors.lastname: Perez
authors.forename: Bruno
authors.initials: B
authors.lastname: Le Grand