Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: report of a case.
Multicentricity of gastrointestinal stromal tumors (GISTs) has been described only in patients with neurofibromatosis type 1 (NF1) or within the small intestine, and different pathogenetic mechanisms are involved. We report a case of synchronous sporadic gastric and jejunal GISTs, which were resected laparoscopically in a 67-year-old man. Immunohistochemical analysis revealed that both lesions were KIT (CD117)-positive, but that the gastric lesion was CD34-positive, whereas the jejunal one was Vimentin-, S-100-, and SMA-positive. Molecular analysis of mutations in KIT exons 9, 11, 13, and 17, and in PDGFRA exons 12 and 18 revealed the presence of a gastric sporadic GIST with a KIT mutation of the exon 11 and a jejunal sporadic GIST without KIT or PDGFRA mutations. To our knowledge, this is the first report of laparoscopically resected synchronous sporadic gastric and jejunal GISTs.
Dell'Avanzato
Roberto
R
Department of General Surgery, S. Eugenio Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
Carboni
Fabio
F
Palmieri
Maria Beatrice
MB
Palmirotta
Raffaele
R
Guadagni
Fiorella
F
Pippa
Giovanna
G
Santeusanio
Giuseppe
G
Antimi
Mauro
M
Lopez
Massimo
M
Carlini
Massimo
M