title: Is heart rate variability related to gait impairment in patients with Parkinson's disease? A pilot study.
abstract: OBJECTIVE
  Impairments in gait and autonomic function are common in patients with Parkinson's disease (PD). These are likely independent symptoms, based on different etiologic mechanisms. However, a few recent reports have observed an association between motor function, in particular gait impairment, and autonomic function in PD. In those studies, the Unified Parkinson's Disease Rating Scale (UPDRS) was used to evaluate gait and motor function. The present study was performed to further examine this putative relationship using quantitative measures of autonomic function and gait in order to shed light on the underlying pathophysiology of these symptoms.
  
  
  METHODS
  Nine healthy young, 15 healthy elderly and 18 PD patients were studied. Heart rate variability (HRV) measures were collected during rest. Gait speed, swing time and swing time variability were measured during a 1-min walk at comfortable speed. The motor portion of the UPDRS was also evaluated in all subjects.
  
  
  RESULTS
  HRV values were highest in the young adults, intermediate in the healthy elderly controls, and lowest in the PD patients. Gait measures tended to deteriorate with age and were significantly worse in the PD patients, compared to the elderly controls. HRV was not correlated with any measure of gait performance (p>0.129) nor with the UPDRS-motor score (p>0.147).
  
  
  CONCLUSIONS
  The present findings support the idea that gait and autonomic function impairments co-exist in PD, but their etiology is based on distinct pathophysiological pathways, with minimal overlap.
authors.affiliation: Department of Neurology, Tel Aviv Sourasky Medical Center, Tel-Aviv, Israel.
authors.forename: M B
authors.initials: MB
authors.lastname: Aerts
authors.forename: N E
authors.initials: NE
authors.lastname: Synhaeve
authors.forename: A
authors.initials: A
authors.lastname: Mirelman
authors.forename: B R
authors.initials: BR
authors.lastname: Bloem
authors.forename: N
authors.initials: N
authors.lastname: Giladi
authors.forename: J M
authors.initials: JM
authors.lastname: Hausdorff