title: White matter alterations in male patients with obsessive-compulsive disorder.
abstract: To investigate white matter abnormalities in patients with obsessive-compulsive disorder and to clarify the relationship between discrete white matter alterations and obsessive-compulsive symptom dimensions, the fractional anisotropy obtained from 25 male patients and 25 matched normal controls were analyzed. The patients had a significantly lower fractional anisotropy in the left anterior cingulate white matter than the controls. When stratified by clinical symptom dimensions, patients with a predominant aggressive/checking symptom dimension exhibited a significantly lower fractional anisotropy in the left anterior cingulate white matter, whereas patients with a predominant contamination/cleaning symptom dimension showed a significantly higher fractional anisotropy in the bilateral prefrontal white matter. Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes.
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Tae Hyon
authors.initials: TH
authors.lastname: Ha
authors.forename: Do-Hyung
authors.initials: DH
authors.lastname: Kang
authors.forename: Jun Sung
authors.initials: JS
authors.lastname: Park
authors.forename: Joon Hwan
authors.initials: JH
authors.lastname: Jang
authors.forename: Wi Hoon
authors.initials: WH
authors.lastname: Jung
authors.forename: Jung-Seok
authors.initials: JS
authors.lastname: Choi
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Park
authors.forename: Myung Hun
authors.initials: MH
authors.lastname: Jung
authors.forename: Chi-Hoon
authors.initials: CH
authors.lastname: Choi
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Kyooseob
authors.initials: K
authors.lastname: Ha
authors.forename: Jun Soo
authors.initials: JS
authors.lastname: Kwon