A sulfur-terminal Zn(II) complex and its two-photon microscopy biological imaging application.
A novel sulfur-terminal Zn(II) complex Zn(S)(2)L (L = N-hexyl-3-{2-[4-(2,2':6',2''-terpyridin-4'-yl)phenyl] ethenyl}carbazole) was obtained by a facile solvothermal process. The unique feature in this new reaction design is the use of ZnS nanocrystals as a precursor and bulky chromophoric L as an ancillary ligand. The versatility of the two terminal sulfur atoms is relevant to biological system. The resulting Zn(S)(2)L complex shows two-photon excited fluorescence (TPEF), which has been proven to be potentially useful for two-photon microscopy imaging in living cells. In addition, cytotoxicity tests showed that the low-micromolar concentrations of Zn(S)(2)L did not cause significant reduction in cell viability over a period of at least 24 h and should be safe for further biological studies.
Gao
Yuanhao
Y
Department of Chemistry, Key Laboratory of Inorganic Materials Chemistry of Anhui Province, Anhui University, Hefei 230039, PR China.
Wu
Jieying
J
Li
Yiming
Y
Sun
Pingping
P
Zhou
Hongping
H
Yang
Jiaxiang
J
Zhang
Shengyi
S
Jin
Baokang
B
Tian
Yupeng
Y