title: Catalytic asymmetric synthesis of piperidines from pyrrolidine: concise synthesis of L-733,060.
abstract: Catalytic asymmetric deprotonation-aldehyde trapping-ring expansion from a 5- to a 6-ring delivers a concise route to each stereoisomer of beta-hydroxy piperidines starting from N-Boc pyrrolidine. The methodology is utilized in a 5-step catalytic asymmetric synthesis of the neorokinin-1 receptor antagonist, (+)-L-733,060.
authors.affiliation: Department of Chemistry, University of York, Heslington, York YO10 5DD, United Kingdom.
authors.forename: Julia L
authors.initials: JL
authors.lastname: Bilke
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Moore
authors.forename: Peter
authors.initials: P
authors.lastname: O'Brien
authors.forename: John
authors.initials: J
authors.lastname: Gilday