Predictive value of early 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) during salvage chemotherapy in relapsing/refractory Hodgkin lymphoma (HL) treated with high-dose chemotherapy.
This retrospective study evaluated whether early 2-[fluorine-18]fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) after two cycles of salvage chemotherapy (PET2) could predict survival after high-dose chemotherapy (HDC). Twenty-four Hodgkin lymphoma (HL) patients were included. PET2 was negative in 58% and positive in 42% of patients. Ninety per cent of patients (9/10) with positive PET2 relapsed after HDC while all but one patient with negative PET2 maintained a complete remission. The 2-year progression-free survival was 93% vs. 10% for patients with negative and positive PET2, respectively (P < 0.001). This study shows that interim PET can predict the outcome after high-dose chemotherapy in HL patients.
Castagna
Luca
L
Oncology and Haematology Department, Istituto Clinico Humanitas, Rozzano (MI), Italy. luca.castagna@humanitas.it
Bramanti
Stefania
S
Balzarotti
Monica
M
Sarina
Barbara
B
Todisco
Elisabetta
E
Anastasia
Antonella
A
Magagnoli
Massimo
M
Mazza
Rita
R
Nozza
Andrea
A
Giordano
Laura
L
Rodari
Marcello
M
Rinifilo
Eva
E
Chiti
Arturo
A
Santoro
Armando
A