title: Sulfated and non-sulfated glycopeptide recognition domains of P-selectin glycoprotein ligand 1 and their binding to P- and E-selectin.
abstract: Total synthesis through block glycosylation and selective chemical O-sulfation of tyrosine residues yielded the glycopeptide recognition domain A (X=SO(3) (-)) of the P-selectin glycoprotein ligand 1, in which the terminal sialic acid of the complex hexasaccharide side chain was replaced by (S)-cyclohexyl lactic acid. In binding assays the O-sulfated structure A showed high affinity towards P-selectin, the non-sulfated towards E-selectin.
authors.affiliation: Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz, Duesbergweg 10-14, 55128 Mainz, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Baumann
authors.forename: Danuta
authors.initials: D
authors.lastname: Kowalczyk
authors.forename: Tobias
authors.initials: T
authors.lastname: Gutjahr
authors.forename: Markus
authors.initials: M
authors.lastname: Pieczyk
authors.forename: Claire
authors.initials: C
authors.lastname: Jones
authors.forename: Martin K
authors.initials: MK
authors.lastname: Wild
authors.forename: Dietmar
authors.initials: D
authors.lastname: Vestweber
authors.forename: Horst
authors.initials: H
authors.lastname: Kunz