title: Signs of reduced angiogenic activity after surgical removal of deeply infiltrating endometriosis.
abstract: OBJECTIVE
  To study the concentrations of vascular endothelial growth factor A (VEGF-A), soluble vascular endothelial growth factor receptors-1 and -2 (sVEGFR-1 and -2), angiogenin, and angiopoietin-2 (Ang-2) in serum and peritoneal fluid from healthy controls and women with advanced endometriosis. Further, we addressed the question of whether surgical removal of endometriotic lesions was associated with normalization of the serum concentrations of the same markers.
  
  
  METHODS
  Patients with endometriosis before and after surgery were compared with control patients.
  
  
  METHODS
  University Hospital.
  
  
  METHODS
  Twenty-one healthy controls and 32 women with advanced endometriosis.
  
  
  METHODS
  In women with endometriosis we performed surgical removal of endometriotic lesions using laparoscopy.
  
  
  METHODS
  Data on serum and peritoneal fluid concentrations of selected markers in healthy controls and women with endometriosis before surgery and in serum 5 to 7 days after surgery.
  
  
  RESULTS
  Women with endometriosis had elevated levels of VEGF-A, sVEGFR-1, and Ang-2 in serum and all studied markers in peritoneal fluid compared with healthy controls. Surgical removal of endometriotic lesions resulted in decreased serum levels of pro-angiogenic VEGF-A and increased levels of sVEGFR-2 that negatively regulates the action of VEGF.
  
  
  CONCLUSIONS
  Women with advanced endometriosis have serum and peritoneal fluid concentrations of several factors involved in the regulation of angiogenesis that differ from those in healthy women, and these changes at least partly normalize within a week after surgical removal of the endometriotic lesions.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Bourlev
authors.forename: Natalia
authors.initials: N
authors.lastname: Iljasova
authors.forename: Leyla
authors.initials: L
authors.lastname: Adamyan
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
authors.forename: Matts
authors.initials: M
authors.lastname: Olovsson