title: Edema as a very early marker for acute myocardial ischemia: a cardiovascular magnetic resonance study.
abstract: OBJECTIVE
  This study was designed to determine whether imaging myocardial edema would identify acute myocardial ischemia before irreversible injury takes place.
  
  
  BACKGROUND
  Early identification of acute myocardial ischemia is a diagnostic challenge.
  
  
  METHODS
  We studied 15 dogs with serial T(2)-weighted and cine imaging at baseline, during transient coronary occlusion of up to 35 min, and after reperfusion in a 1.5-T magnetic resonance imaging system. Late gadolinium enhancement and troponin measurements were used to assess for the presence of irreversible injury. Myocardial water content was measured to assess myocardial edema.
  
  
  RESULTS
  We consistently observed a transmural area of high T(2) signal intensity matching areas with new onset regional akinesia 28 +/- 4 min after experimental coronary artery occlusion. At this time, the contrast-to-noise ratio between the ischemic and remote myocardium had significantly increased from 1.0 +/- 2.0 to 12.8 +/- 9.6 (p < 0.003), which further increased after reperfusion to 15.8 +/- 10.3 (p < 0.004 compared with baseline). Neither myocardial late gadolinium enhancement nor troponin elevation were noted at this time window. Myocardial water content of the ischemic segments was consistently higher (68.9 +/- 2% vs. 67.0 +/- 2%; p < 0.004) than in remote segments and the difference correlated significantly to the contrast-to-noise ratio in T(2) images (p < 0.04).
  
  
  CONCLUSIONS
  We provide the first evidence that T(2)-weighted cardiovascular magnetic resonance imaging of edema detects acute ischemic myocyte injury before the onset of irreversible injury. T(2)-weighted cardiovascular magnetic resonance imaging may serve as a very useful diagnostic marker in clinical settings such as unstable angina or evolving infarction.
authors.affiliation: Stephenson CMR Centre at the Libin Cardiovascular Institute of Alberta, Calgary, Alberta, Canada.
authors.forename: Hassan
authors.initials: H
authors.lastname: Abdel-Aty
authors.forename: Myra
authors.initials: M
authors.lastname: Cocker
authors.forename: Cheryl
authors.initials: C
authors.lastname: Meek
authors.forename: John V
authors.initials: JV
authors.lastname: Tyberg
authors.forename: Matthias G
authors.initials: MG
authors.lastname: Friedrich