title: A case of cold agglutinin disease in the course of treatment for polymyalgia rheumatica.
abstract: A 60-year-old male who had been treated for polymyalgia rheumatica (PMR) with Raynaud's phenomenon was admitted to our hospital with acrocyanosis and rapid progressive anemia. Hemolytic anemia with reduction of haptoglobin and cold agglutinin was detected, and the patient had a negative Donath-Landsteiner test. A skin biopsy from his toe revealed microthromboembolism without vasculitis, resulting in the diagnosis of cold agglutinin disease (CAD). This is a first case report of CAD complicated with PMR.
authors.affiliation: Unit of Translational Medicine, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, Nagasaki 852-8501, Japan. nhideki@nagasaki-u.ac.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Kayo
authors.initials: K
authors.lastname: Kamiya-Matsumoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ida
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihira
authors.forename: Katsumi
authors.initials: K
authors.lastname: Eguchi