title: t(5;6;12) associated with resistance to imatinib mesylate in chronic myeloid leukemia.
abstract: A patient with t(9;22)-positive chronic myelogenous leukemia (CML) developed a resistance to therapy with imatinib mesylate (Glivec) which coincided with the appearance of t(5;6;12) in the same cells with t(9;22) [46,XX,t(5;6;12)(q14?;q21?;q23?),t(9;22)(q34;q11)]. She remains in a continuous chronic phase of CML. This is the first reported instance of karyotype evolution temporally associated, and possibly involved, with the induction of resistance to imatinib mesylate but without any signs of evolution of leukemia toward a more anaplastic and aggressive form.
authors.affiliation: Clinical Center Serbia, Institute of Hematology, Koste Todorovića 2 Street, 11000, Belgrade, Serbia. mdencicfekete@yahoo.com.
authors.forename: Marija
authors.initials: M
authors.lastname: Denčić-Fekete
authors.affiliation: Clinical Center Serbia, Institute of Hematology, Koste Todorovića 2 Street, 11000, Belgrade, Serbia.
authors.forename: Vesna
authors.initials: V
authors.lastname: Đorđević
authors.affiliation: Department of Genetics and Microbiology, University of Bari, Bari, Italy.
authors.forename: Clelia Tiziana
authors.initials: CT
authors.lastname: Storlazzi
authors.affiliation: Clinical Center Serbia, Institute of Hematology, Koste Todorovića 2 Street, 11000, Belgrade, Serbia.
authors.forename: Gradimir
authors.initials: G
authors.lastname: Janković
authors.affiliation: Clinical Center Serbia, Institute of Hematology, Koste Todorovića 2 Street, 11000, Belgrade, Serbia.
authors.forename: Andrija
authors.initials: A
authors.lastname: Bogdanović
authors.affiliation: Clinical Center Serbia, Institute of Hematology, Koste Todorovića 2 Street, 11000, Belgrade, Serbia.
authors.forename: Jelica
authors.initials: J
authors.lastname: Jovanović
authors.affiliation: Department of Genetics and Microbiology, University of Bari, Bari, Italy.
authors.forename: Mariano
authors.initials: M
authors.lastname: Rocchi
authors.affiliation: Military Medical Academy, 11000, Belgrade, Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Todorić-Živanović
authors.affiliation: Military Medical Academy, 11000, Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Strnad
authors.affiliation: Clinical Center Serbia, Institute of Hematology, Koste Todorovića 2 Street, 11000, Belgrade, Serbia.
authors.forename: Mirjana
authors.initials: M
authors.lastname: Gotić