Protease responsive nanoprobes with tethered fluorogenic peptidyl 3-arylcoumarin substrates.
Protease responsive nanosensors were obtained by the attachment of unique green fluorescent bifunctional 3-arylcoumarin-derived fluorogenic substrates to poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) nanoparticles, in which proteolysis results in substantial signal amplification.
Welser
Katharina
K
School of Pharmacy, Centre for Biomolecular Sciences, University of Nottingham, University Park, Nottingham, UKNG7 2RD.
Grilj
Jakob
J
Vauthey
Eric
E
Aylott
Jonathan W
JW
Chan
Weng C
WC