[Tobacco smoking and drug interactions].
Tobacco smoking increases the turnover of many drugs due to induction of drug-metabolizing enzymes. Smokers therefore require higher doses of agents such as clozapine, olanzapine and theophylline than non- smokers. Enzyme induction declines after smoking cessation and without concomitant dose reduction there is an increased risk of adverse effects.
Molden
Espen
E
Farmasøytisk institutt Universitetet i Oslo Postboks 1068 Blindern 0316 Oslo. espen.molden@farmasi.uio.no
Spigset
Olav
O