An expanded phenotype of maternal SSA/SSB antibody-associated fetal cardiac disease.
OBJECTIVE
Conventional manifestations of fetal Sjogren's antibodies (SSA/SSB) associated cardiac disease include atrioventricular block (AVB), transient sinus bradycardia, endocardial fibroelastosis (EFE) and dilated cardiomyopathy. We describe other manifestations of cardiac disease.


METHODS
We describe three fetuses with unique myocardial and conduction system disease.


RESULTS
One had isolated EFE with subsequent mitral and tricuspid valve chordal avulsion, the second had sinoatrial and infrahissian conduction system disease, and in both, neonatal progression to life threatening disease occurred. The third had sinus node dysfunction and atrial flutter.


CONCLUSIONS
These findings expand the clinical phenotype of maternal SSA/SSB antibody associated fetal cardiac disease.
Cuneo
Bettina F
BF
The Heart Institute for Children, Hope Children's Hospital, Oak Lawn, IL 60453, USA. cuneo@thic.com
Strasburger
Janette F
JF
Niksch
Alisa
A
Ovadia
Marc
M
Wakai
Ronald T
RT