Antifungal and anthelmintic activities of Cleistopholis patens (Annonaceae).
Basic CH2Cl2 extract of the trunk bark of Cleistopholis patens (Annonaceae) exhibited antifungal activities against Candida albicans, C. parapsilosis, and C. glabrata using an agar well-diffusion assay method. Bioassay-guided fractionation of the extract led to the isolation of 8-hydroxysampangine. The methanolic extract displayed anthelmintic activity against Rhabditis pseudoelongata. Purification of the neutral CH2Cl2 extract yielded bornyl-p-transcoumarate and bornyl-p-cis-coumarate.
Akendengué
Blandine
B
Département de Pharmacologie, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon. akenblan@yahoo.fr
Champy
Pierre
P
Nzamba
Joseph
J
Roblot
François
F
Loiseau
Philippe M
PM
Bories
Christian
C