Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia.
BACKGROUND
The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes.


METHODS
Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay.


RESULTS
We recruited 333 subjects (186 females and 147 males), aged 56.1 +/- 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p < 0.0001) and lasted until 2 h (p < 0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = -0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG > or = 5.55 mmol/l (p = 0.025) but not in those with FPG < 5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference.


CONCLUSIONS
Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.
Li
Hung-Yuan
HY
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Wei
Jung-Nan
JN
Lin
Mao-Shin
MS
Smith
David J
DJ
Vainio
Jani
J
Lin
Cheng-Hsin
CH
Chiang
Fu-Tien
FT
Shih
Shyang-Rong
SR
Huang
Ching-Huei
CH
Wu
Mei-Yu
MY
Hsein
Yenh-Chen
YC
Chuang
Lee-Ming
LM