Acylated flavonol bisdesmosides, sinocrassosides A3-A7 and B3, with aminopeptidase N inhibitory activity from Sinocrassula indica.
Six new acylated flavonol bisdesmosides, sinocrassosides A(3), A(4), A(5), A(6), A(7), and B(3) (1-6, resp.), were isolated from the MeOH extract of the whole plant of Sinocrassula indica. The structures of 1-6 were elucidated on the basis of chemical and physicochemical evidence. Among them, 2 and 6 which have an acyl group in the 3'''-position were found to show strong inhibitory effects on aminopeptidase N activity, which were stronger than that of curcumin.
Morikawa
Toshio
T
Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto, Japan.
Xie
Haihui
H
Wang
Tao
T
Matsuda
Hisashi
H
Yoshikawa
Masayuki
M