title: A short and efficient synthesis of (-)-7-methylomuralide, a potent proteasome inhibitor.
abstract: Short, practical, and scalable syntheses of (+/-)-7-methylomuralide and (-)-7-methylomuralide have been developed. Three consecutive tandem reaction pairs establish all of the carbons and the stereochemistry of the target molecule, vastly simplifying the synthetic scheme from N-trichloroethoxycarbonyl glycine. The chiral directing group controls the absolute stereochemistry of the key aldol reaction.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: Ryan A
authors.initials: RA
authors.lastname: Shenvi
authors.forename: E J
authors.initials: EJ
authors.lastname: Corey