title: Heritability and linkage analysis of appendicitis utilizing age at onset.
abstract: Appendicitis usually afflicts the young, but there is a large tail in the distribution of onset age. The genetics of this disease are still not well understood. A heritability analysis and genome wide linkage analysis of a large twin dataset was undertaken. Treating age of onset of appendicitis as a censored survival trait revealed a heritability of 0.21, and found evidence of linkage to Chromosome 1p37.3.
authors.affiliation: Department of Mathematical Sciences, Queensland University of Technology, Brisbane, Australia. c.oldmeadow@student.qut.edu.au
authors.forename: Christopher
authors.initials: C
authors.lastname: Oldmeadow
authors.forename: Kerrie
authors.initials: K
authors.lastname: Mengersen
authors.forename: Nicholas
authors.initials: N
authors.lastname: Martin
authors.forename: David L
authors.initials: DL
authors.lastname: Duffy