title: Laser-induced hyperthermia for treatment of granulation tissue growth in rats.
abstract: OBJECTIVE
  We aimed to develop a new technique for treatment of granulation tissue (GT) growth using local hyperthermia.
  
  
  METHODS
  A temperature-controlled diode laser system was developed for induction of mild hyperthermia in real time. GT was generated by harvesting the skin over the gluteal fascia in rats. Histopathological analysis was used to estimate the effect of hyperthermia on the tissue.
  
  
  RESULTS
  In untreated rats, GT was detected within 3 days and reached maximal thickness after 12 days. Hyperthermia at 43 degrees C and above significantly decreased GT thickness (n = 8 per group). Hyperthermia at 48 degrees C for 3 minutes was the most efficient parameter for treatment of GT (51% reduction), with minimal (5%) muscle necrosis.
  
  
  CONCLUSIONS
  Hyperthermia can significantly inhibit GT growth, with minimal damage to surrounding structures. Our findings suggest a possible role for hyperthermia as a therapeutic model against GT. Further research and long-term studies are needed to explore the utility of laser-induced hyperthermia for inhibition of GT growth.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Roee
authors.initials: R
authors.lastname: Landsberg
authors.forename: Ari
authors.initials: A
authors.lastname: DeRowe
authors.forename: Abraham
authors.initials: A
authors.lastname: Katzir
authors.forename: Alexander
authors.initials: A
authors.lastname: Shtabsky
authors.forename: Dan M
authors.initials: DM
authors.lastname: Fliss
authors.forename: Ziv
authors.initials: Z
authors.lastname: Gil