title: Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs.
abstract: The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 microg/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T(4) and T(3) in exposed lambs without any effect in pregnant sheep. Our finding indicates that prenatal low-dose PBDE exposure results in PBDE storage in fat of offspring and can affect thyroid metabolism in the developing fetus.
authors.affiliation: Département d'Obstétrique et de Gynécologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Qué., Canada.
authors.forename: Nadia
authors.initials: N
authors.lastname: Abdelouahab
authors.forename: Alexander
authors.initials: A
authors.lastname: Suvorov
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Pasquier
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Langlois
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Praud
authors.forename: Larissa
authors.initials: L
authors.lastname: Takser