Models of ovarian cancer metastasis: Murine models.
Mice have mainly been used in ovarian cancer research as immunodeficient hosts for cell lines derived from the primary tumors and ascites of ovarian cancer patients. These xenograft models have provided a valuable system for pre-clinical trials, however, the genetic complexity of human tumors has precluded the understanding of key events that drive metastatic dissemination. Recently developed immunocompetent, genetically defined mouse models of epithelial ovarian cancer represent significant improvements in the modeling of metastatic disease.
Sale
Sanja
S
Massachusetts General Hospital, Harvard Medical School, 13th Street, Building 149, CNY7, Charlestown, MA 02129, United States.
Orsulic
Sandra
S