Commentary: the prospect of cell-based therapy for epilepsy.
About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel approaches are needed to prevent or alleviate epileptogenic process after various types of brain injuries. The use of cell transplants as factories to produce endogeneous anticonvulsants or as bricks to repair abnormal ictogenic and epileptogenic neuronal circuits has generated hope that cell-based therapies could become a novel therapeutic category in the treatment arsenal of epilepsy. Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy.
Kriegstein
Arnold R
AR
Department of Neurology, University of California, San Francisco, California 94143-0525, USA. kriegsteina@stemcell.ucsf.edu
Pitkänen
Asla
A