title: Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus.
abstract: We studied the role of osteopontin (OPN) in host responses against rotavirus (RV) infection. OPN knockout (OPN-KO) suckling mice were more susceptible to RV (strain EW) infection and showed prolonged diarrhea duration compared to wild-type (WT) suckling mice. OPN in the small intestine of WT mice was expressed after 48 h post-infection. On day 2 postinfection, mRNA levels of interleukin-1beta, tumor necrosis factor-alpha, and interleukin-15 in OPN-KO mice were lower than in WT mice, although mRNA expression of Th-1- and Th-2-related cytokines in the small intestine were nearly the same between OPN-KO and WT mice. These results suggested that OPN is involved in innate responses against RV infection.
authors.affiliation: Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. ymaeno@fujita-hu.ac.jp
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Maeno
authors.forename: Masanori
authors.initials: M
authors.lastname: Shinzato
authors.forename: Shigeo
authors.initials: S
authors.lastname: Nagashima
authors.forename: Susan R
authors.initials: SR
authors.lastname: Rittling
authors.forename: David T
authors.initials: DT
authors.lastname: Denhardt
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Uede
authors.forename: Koki
authors.initials: K
authors.lastname: Taniguchi