title: Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.
abstract: Somatically acquired epigenetic changes are present in many cancers. Epigenetic regulation is maintained via post-translational modifications of core histones. Here, we describe inactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysine methylation deregulation in multiple tumor types. UTX reintroduction into cancer cells with inactivating UTX mutations resulted in slowing of proliferation and marked transcriptional changes. These data identify UTX as a new human cancer gene.
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, UK.
authors.forename: Gijs
authors.initials: G
authors.lastname: van Haaften
authors.forename: Gillian L
authors.initials: GL
authors.lastname: Dalgliesh
authors.forename: Helen
authors.initials: H
authors.lastname: Davies
authors.forename: Lina
authors.initials: L
authors.lastname: Chen
authors.forename: Graham
authors.initials: G
authors.lastname: Bignell
authors.forename: Chris
authors.initials: C
authors.lastname: Greenman
authors.forename: Sarah
authors.initials: S
authors.lastname: Edkins
authors.forename: Claire
authors.initials: C
authors.lastname: Hardy
authors.forename: Sarah
authors.initials: S
authors.lastname: O'Meara
authors.forename: Jon
authors.initials: J
authors.lastname: Teague
authors.forename: Adam
authors.initials: A
authors.lastname: Butler
authors.forename: Jonathan
authors.initials: J
authors.lastname: Hinton
authors.forename: Calli
authors.initials: C
authors.lastname: Latimer
authors.forename: Jenny
authors.initials: J
authors.lastname: Andrews
authors.forename: Syd
authors.initials: S
authors.lastname: Barthorpe
authors.forename: Dave
authors.initials: D
authors.lastname: Beare
authors.forename: Gemma
authors.initials: G
authors.lastname: Buck
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Campbell
authors.forename: Jennifer
authors.initials: J
authors.lastname: Cole
authors.forename: Simon
authors.initials: S
authors.lastname: Forbes
authors.forename: Mingming
authors.initials: M
authors.lastname: Jia
authors.forename: David
authors.initials: D
authors.lastname: Jones
authors.forename: Chai Yin
authors.initials: CY
authors.lastname: Kok
authors.forename: Catherine
authors.initials: C
authors.lastname: Leroy
authors.forename: Meng-Lay
authors.initials: ML
authors.lastname: Lin
authors.forename: David J
authors.initials: DJ
authors.lastname: McBride
authors.forename: Mark
authors.initials: M
authors.lastname: Maddison
authors.forename: Simon
authors.initials: S
authors.lastname: Maquire
authors.forename: Kirsten
authors.initials: K
authors.lastname: McLay
authors.forename: Andrew
authors.initials: A
authors.lastname: Menzies
authors.forename: Tatiana
authors.initials: T
authors.lastname: Mironenko
authors.forename: Lee
authors.initials: L
authors.lastname: Mulderrig
authors.forename: Laura
authors.initials: L
authors.lastname: Mudie
authors.forename: Erin
authors.initials: E
authors.lastname: Pleasance
authors.forename: Rebecca
authors.initials: R
authors.lastname: Shepherd
authors.forename: Raffaella
authors.initials: R
authors.lastname: Smith
authors.forename: Lucy
authors.initials: L
authors.lastname: Stebbings
authors.forename: Philip
authors.initials: P
authors.lastname: Stephens
authors.forename: Gurpreet
authors.initials: G
authors.lastname: Tang
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Tarpey
authors.forename: Rachel
authors.initials: R
authors.lastname: Turner
authors.forename: Kelly
authors.initials: K
authors.lastname: Turrell
authors.forename: Jennifer
authors.initials: J
authors.lastname: Varian
authors.forename: Sofie
authors.initials: S
authors.lastname: West
authors.forename: Sara
authors.initials: S
authors.lastname: Widaa
authors.forename: Paul
authors.initials: P
authors.lastname: Wray
authors.forename: V Peter
authors.initials: VP
authors.lastname: Collins
authors.forename: Koichi
authors.initials: K
authors.lastname: Ichimura
authors.forename: Simon
authors.initials: S
authors.lastname: Law
authors.forename: John
authors.initials: J
authors.lastname: Wong
authors.forename: Siu Tsan
authors.initials: ST
authors.lastname: Yuen
authors.forename: Suet Yi
authors.initials: SY
authors.lastname: Leung
authors.forename: Giovanni
authors.initials: G
authors.lastname: Tonon
authors.forename: Ronald A
authors.initials: RA
authors.lastname: DePinho
authors.forename: Yu-Tzu
authors.initials: YT
authors.lastname: Tai
authors.forename: Kenneth C
authors.initials: KC
authors.lastname: Anderson
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kahnoski
authors.forename: Aaron
authors.initials: A
authors.lastname: Massie
authors.forename: Sok Kean
authors.initials: SK
authors.lastname: Khoo
authors.forename: Bin Tean
authors.initials: BT
authors.lastname: Teh
authors.forename: Michael R
authors.initials: MR
authors.lastname: Stratton
authors.forename: P Andrew
authors.initials: PA
authors.lastname: Futreal