title: A microfluidic high-resolution NMR flow probe.
abstract: A microfluidic high-resolution NMR flow probe based on a novel stripline detector chip is demonstrated. This tool is invaluable for the in situ monitoring of reactions performed in microreactors. As an example, the acetylation of benzyl alcohol with acetyl chloride was monitored. Because of the uncompromised (sub-Hz) resolution, this probe holds great promise for metabolomics studies, as shown by an analysis of 600 nL of human cerebrospinal fluid.
authors.affiliation: Mesa+ Institute for Nanotechnology, University of Twente, Drienerlolaan 5, 7522 NB Enschede, The Netherlands.
authors.forename: Jacob
authors.initials: J
authors.lastname: Bart
authors.forename: Ard J
authors.initials: AJ
authors.lastname: Kolkman
authors.forename: Anna Jo
authors.initials: AJ
authors.lastname: Oosthoek-de Vries
authors.forename: Kaspar
authors.initials: K
authors.lastname: Koch
authors.forename: Pieter J
authors.initials: PJ
authors.lastname: Nieuwland
authors.forename: Hans J W G
authors.initials: HJ
authors.lastname: Janssen
authors.forename: Jan P J M
authors.initials: JP
authors.lastname: van Bentum
authors.forename: Kirsten A M
authors.initials: KA
authors.lastname: Ampt
authors.forename: Floris P J T
authors.initials: FP
authors.lastname: Rutjes
authors.forename: Sybren S
authors.initials: SS
authors.lastname: Wijmenga
authors.forename: Han J G E
authors.initials: HJ
authors.lastname: Gardeniers
authors.forename: Arno P M
authors.initials: AP
authors.lastname: Kentgens