title: Containment of infection in tat vaccinated monkeys after rechallenge with a higher dose of SHIV89.6P(cy243).
abstract: We previously reported that cynomolgus monkeys vaccinated with the human immunodeficiency virus (HIV)-1 Tat protein controlled infection after challenge with the simian human immunodeficiency virus (SHIV) 89.6P(cy243) for up to 2 y of follow-up. To evaluate the breadth of the protective immunity elicited by the Tat protein, the vaccines along with the naïve monkeys were intravenously rechallenged with a fivefold higher dose (50 MID(50)) of the same SHIV-89.6P(cy243). The vaccinated monkeys exhibited a statistically significant and long-lasting reduction of viral replication compared to control monkeys. This effect was associated with a strong anamnestic response to Tat, while responses to Gag and Env were nearly undetectable. Taken together, these data provide further evidence for the usefulness of Tat-based vaccines.
authors.affiliation: National AIDS Center, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: Alessandra
authors.initials: A
authors.lastname: Borsetti
authors.forename: Silvia
authors.initials: S
authors.lastname: Baroncelli
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Maggiorella
authors.forename: Sonia
authors.initials: S
authors.lastname: Moretti
authors.forename: Emanuele
authors.initials: E
authors.lastname: Fanales-Belasio
authors.forename: Leonardo
authors.initials: L
authors.lastname: Sernicola
authors.forename: Antonella
authors.initials: A
authors.lastname: Tripiciano
authors.forename: Iole
authors.initials: I
authors.lastname: Macchia
authors.forename: Zuleika
authors.initials: Z
authors.lastname: Michelini
authors.forename: Roberto
authors.initials: R
authors.lastname: Belli
authors.forename: Stefania
authors.initials: S
authors.lastname: Farcomeni
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Pavone-Cossut
authors.forename: Donatella
authors.initials: D
authors.lastname: Negri
authors.forename: Antonella
authors.initials: A
authors.lastname: Caputo
authors.forename: Stefania
authors.initials: S
authors.lastname: Bellino
authors.forename: Stefano
authors.initials: S
authors.lastname: Butto
authors.forename: Fausto
authors.initials: F
authors.lastname: Titti
authors.forename: Aurelio
authors.initials: A
authors.lastname: Cafaro
authors.forename: Barbara
authors.initials: B
authors.lastname: Ensoli