title: Signaling networks associated with BCR-ABL-dependent transformation.
abstract: BACKGROUND
  The fusion protein BCR-ABL results in constitutive tyrosine kinase activity. It also affects downstream targets as well as the subcellular location of the normally tightly regulated Abl tyrosine kinase.
  
  
  METHODS
  The authors review the current knowledge concerning the signaling networks associated with BCR-ABL-dependent transformation.
  
  
  RESULTS
  Although BCR-ABL is considered a single genetic change, the dysregulated tyrosine kinase activates a network of signals that contributes to cytokine-independent growth, resistance to apoptosis, and genetic instability.
  
  
  CONCLUSIONS
  The effectiveness of BCR-ABL-dependent transformation of hematopoietic stem cells is due not to a single pathway but rather to the culmination of a network of signaling pathways.
authors.affiliation: Molecular Oncology Program, H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida 33612, USA. Lori.Hazlehurst@moffitt.org
authors.forename: Lori A
authors.initials: LA
authors.lastname: Hazlehurst
authors.forename: Nadine N
authors.initials: NN
authors.lastname: Bewry
authors.forename: Rajesh R
authors.initials: RR
authors.lastname: Nair
authors.forename: Javier
authors.initials: J
authors.lastname: Pinilla-Ibarz