Isocyanide-based two-step three-component keteneimine formation.
The addition of isocyanides to acyl chlorides (Isocyanide-Nef reaction) leads to imidoyl chlorides which can later be treated with trialkylphosphites to afford new keteneimines in a Perkow-type reaction. The whole sequence may be performed without any solvent, and the resulting keteneimine may easily be converted to phosphorylated tetrazoles and triazoles.
Coffinier
Didier
D
Laboratoire Chimie et Procedes, Ecole Nationale Superieure de Techniques Avancees, 32 Bd Victor, 75739 Paris Cedex 15, France.
El Kaim
Laurent
L
Grimaud
Laurence
L