title: O6-(benzotriazol-1-yl)inosine derivatives for C6 modification of purine nucleosides.
abstract: A new class of reactive nucleosides, O(6)-(benzotriazol-1-yl) derivatives of inosine and 2'-deoxyinosine, have been developed via reaction of silyl-protected or unprotected inosine and 2'-deoxyinosine with 1H-benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate (BOP). Alternatively, the silyl-protected O(6)-(benzotriazol-1-yl) derivatives can be synthesized via reaction of protected inosine and 2'-deoxyinosine with triphenylphosphine/iodine/1-hydroxybenzotriazole. These new O(6)-(benzotriazol-1-yl) inosine derivatives are excellent reagents for the synthesis of other nucleoside analogues via S(N)Ar reaction with a range of nucleophiles.
authors.affiliation: The City College and The City University of New York, New York, USA.
authors.forename: Suyeal
authors.initials: S
authors.lastname: Bae
authors.forename: Surendra
authors.initials: S
authors.lastname: Chaturvedi
authors.forename: Mahesh K
authors.initials: MK
authors.lastname: Lakshman