Zafirlukast (Accolate): A new treatment for capsular contracture.
BACKGROUND
Capsular contracture after breast augmentation or reconstructive breast surgery is a difficult problem. Previous studies have suggested that alteration of the inflammatory response could have a role in reducing the incidence of capsular contracture.


OBJECTIVE
We report a series of patients with Baker class III or IV capsular contracture who underwent treatment with zafirlukast.


METHODS
Patients received a regimen of zafirlukast 20 mg by mouth 2 times daily for 3 months.


RESULTS
In many cases, dramatic softening of the breast capsule was evident after 1 to 3 months of treatment.


CONCLUSIONS
Zafirlukast appears to effectively soften early capsular contracture and may prevent the formation of capsular contracture in those patients at risk. (Aesthetic Surg J 2002;22:329-336.).
Schlesinger
S Larry
SL
Ellenbogen
Richard
R
Desvigne
Michael N
MN
Svehlak
Steven
S
Heck
Robert
R