title: A new alternative for a transjugular intrahepatic portosystemic shunt: EUS-guided creation of an intrahepatic portosystemic shunt (with video).
abstract: BACKGROUND
  Transjugular intrahepatic portosystemic shunt (TIPSS) is an effective treatment for portal hypertension and its associated complications. EUS-guided creation of an intrahepatic portosystemic shunt (IPSS) may become a useful alternative to conventional TIPSS.
  
  
  OBJECTIVE
  To assess the feasibility of EUS-guided IPSS creation in a live porcine model.
  
  
  METHODS
  Acute and survival experiments in 50-kg pigs.
  
  
  METHODS
  Under linear-array EUS guidance, the hepatic vein (HV) and then the portal vein (PV) were punctured with a 19-gauge FNA needle. A 0.035-inch guidewire was advanced through the needle into the PV lumen. The needle was exchanged over the wire, a metal stent was deployed under EUS and fluoroscopic guidance, and the distal end of the stent was positioned inside the PV and the proximal end within the HV. Eight animals were euthanized after the procedure, and 2 animals were kept alive for 2 weeks.
  
  
  METHODS
  Successful EUS-guided IPSS creation.
  
  
  RESULTS
  Portosystemic shunt placement was successful in all animals. Intrahepatic vascular puncture and stent deployment were technically easy. Portosystemic flow through the shunt was documented by portal venogram and EUS Doppler. Necropsy performed after acute and survival experiments revealed no evidence of bleeding or damage to any intraperitoneal organs. There were no complications during the follow-up period in the 2 animals that were kept alive.
  
  
  CONCLUSIONS
  Experiments were performed in healthy animals with normal PV pressure.
  
  
  CONCLUSIONS
  EUS-guided IPSS creation is technically feasible and may become an alternative to the currently used method of TIPSS placement.
authors.affiliation: Institute for Digestive Health and Liver Disease, Mercy Medical Center, Baltimore, Maryland 21202-2165, USA.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Buscaglia
authors.forename: Xavier
authors.initials: X
authors.lastname: Dray
authors.forename: Eun Ji
authors.initials: EJ
authors.lastname: Shin
authors.forename: Priscilla
authors.initials: P
authors.lastname: Magno
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Chmura
authors.forename: Vihar C
authors.initials: VC
authors.lastname: Surti
authors.forename: Travis E
authors.initials: TE
authors.lastname: Dillon
authors.forename: Richard W
authors.initials: RW
authors.lastname: Ducharme
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Donatelli
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Thuluvath
authors.forename: Samuel A
authors.initials: SA
authors.lastname: Giday
authors.forename: Sergey V
authors.initials: SV
authors.lastname: Kantsevoy