Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.
Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.
Ekelund
Elisabeth
E
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. elisabeth.ekelund@ki.se
Bradley
Maria
M
Weidinger
Stephan
S
Jovanovic
Dragan L
DL
Johansson
Catharina
C
Lindgren
Cecilia M
CM
Todorova
Antonia
A
Jakob
Thilo
T
Illig
Thomas
T
von Mutius
Erika
E
Braun-Fahrländer
Charlotte
C
Doekes
Gert
G
Riedler
Josef
J
Scheynius
Annika
A
Pershagen
Göran
G
Kockum
Ingrid
I
Kere
Juha
J