title: [Epidemiology of monogenic hereditary diseases in Rostov Oblast: population dynamic factors determining the differentiation of the load of hereditary diseases in eight districts].
abstract: A genetic epidemiological study has been carried out in eight raions (districts) of Rostov oblast (region) of Russia: Tsimlyansk, Volgodonskoi, Tselina, Egorlykskaya, Millerovo, Tarasovskaya, Rodionovo-Nesvetaiskaya, and Matveevo-Kurgan raions. The population structure (the parameters of the isolation by distance model, ethnic assortative marriage, random inbreeding (F(ST), endogamy index, and ie) and the genetic demographic characteristics of the regional population (vital statistics, Crow's index, and its components) have been analyzed. The total sample size was 320925 subjects (including 114106 and 206816 urban and rural residents, respectively). The load of the main types of Mendelian diseases (autosomal dominant (AD), autosomal recessive (AR), and X-linked diseases) has been calculated for the total sample from eight districts and separately for the urban and rural populations. Substantial differences between individual districts in the AD and AR genetic loads have been found, especially upon separation into urban and rural samples. The results of correlation analysis suggest that migration and genetic drift are the main factors of genetic differentiation of populations with respect to the prevalence of hereditary diseases.
authors.forename: R A
authors.initials: RA
authors.lastname: Zinchenko
authors.forename: S S
authors.initials: SS
authors.lastname: Amelina
authors.forename: G I
authors.initials: GI
authors.lastname: El'chinova
authors.forename: R A
authors.initials: RA
authors.lastname: Val'kov
authors.forename: N V
authors.initials: NV
authors.lastname: Kriventsova
authors.forename: T I
authors.initials: TI
authors.lastname: Val'kova
authors.forename: N V
authors.initials: NV
authors.lastname: Vetrova
authors.forename: R A
authors.initials: RA
authors.lastname: Shokarev
authors.forename: N V
authors.initials: NV
authors.lastname: Petrova
authors.forename: O V
authors.initials: OV
authors.lastname: Khlebnikova