[Azathioprine in inflammatory bowel disease].
OBJECTIVE
Characterisation of an Inflammatory Bowel Disease (IBD) population treated with azathioprine (AZA) and evaluation of AZA safety and efficacy.


METHODS
Retrospective analysis of IBD patients attending our Gastroenterology department in a six months period.


RESULTS
In 137 IBD patients, 30 began AZA treatment; 18 Crohn's disease (CD) and 12 ulcerative colitis (UC). Mean time of treatment was 3.2 years. The reason for treatment was: 76.6% steroid dependent or steroid refractory (SD/SR) disease, 10% prevention of postoperative recurrence in CD, 10% fistulising CD and 3.3% extra intestinal manifestation. Adverse events occurred in 33.3% patients, requiring discontinuation of treatment in 13.3%. Clinical remission rate was 75% in the 28 patients that completed six months treatment (p equal 0.0013): 76.5% for SD/SR disease; 100% for prevention of postoperative recurrence and extra intestinal manifestation; 0% for fistulising CD. The proportion of patients remaining in remission at 12, 24, 36 and 48 months treatment were 87.5% (p lower 0,001), 46.7%, 45.5% e 14.3% (p higher 0,05), respectively.


CONCLUSIONS
Azathioprine can be considered safe in a long term treatment and showed efficacy in induction and maintaining of remission at 12 months.
Leite
Sílvia
S
Serviço de Gastrenterologia, Centro Hospitalar do Alto Ave, Guimarães.
Ribeiro
José Manuel
JM
Lima
Salomé C
SC
Barroso
Sónia
S
Cotter
José
J