Nucleophilic addition onto methyl-4H-1,4-oxazine-3-carboxylate moiety: short access to 1,4-diazine privileged substructures.
To determine the synthetic potential of the original 1,4-oxazine ring, which appears as a valuable building block for the synthesis of more complex derivatives, Michael-type nucleophilic additions were studied. According to the nature of the nucleophile, either acyclic or cyclic derivatives were isolated. In the presence of primary amines, a short and efficient access to diazinic hemiaminals was described.
Claveau
Elise
E
ICOA, UMR CNRS 6005, Université d'Orléans, 45067 Orléans Cedex 2, France.
Gillaizeau
Isabelle
I
Kalinowska-Tluscik
Justyna
J
Bouyssou
Pascal
P
Coudert
Gérard
G