title: Recurent and de novo membranous glomerulopathy after kidney transplantation.
abstract: The aim of this study was to compare the clinical characteristics of recurrent and de novo membranous glomerulopathy (MG) among a cohort of 614 recipients transplanted between 1989 and 2006. Lupus nephritides were excluded. The diagnosis was established on protocol biopsies performed 1, 2, 4, or 8 years after transplantation or because of proteinuria/nephrotic syndrome and/or an increased serum creatinine level. HCV infection, cryoglobulinemia, monoclonal gammopathy, skin cancers, Kaposi sarcoma, diabetes mellitus, anti-HLA antibodies, and graft survival were not significantly different between the groups. Seventeen MG were diagnosed in 15 patients (2.45% of the whole group), including 6 recurrent MG (35%) and 11 de novo MG (75%). Recurrent MG occurred earlier than de novo MG (15.58 +/- 19.13 vs 49.27 +/- 32.71 months). Recipients with de novo MG were more frequently infected with HCV, which seemed to be the main etiologic factor for de novo MG, and may be linked to a Th2 polarization of the immune response.
authors.affiliation: Department of Nephrology and Transplantation, Centre Hospitalier Universitaire, Dijon, France.
authors.forename: A
authors.initials: A
authors.lastname: Aline-Fardin
authors.forename: G
authors.initials: G
authors.lastname: Rifle
authors.forename: L
authors.initials: L
authors.lastname: Martin
authors.forename: E
authors.initials: E
authors.lastname: Justrabo
authors.forename: J B
authors.initials: JB
authors.lastname: Bour
authors.forename: P
authors.initials: P
authors.lastname: D'Athis
authors.forename: Y
authors.initials: Y
authors.lastname: Tanter
authors.forename: C
authors.initials: C
authors.lastname: Mousson