title: Reversible hypogonadism in Bardet-Biedl syndrome.
abstract: OBJECTIVE
  To report a patient with Bardet-Biedl syndrome (BBS) with known hypogonadotrophic hypogonadism who developed spontaneous reversal of hypogonadism in adulthood.
  
  
  METHODS
  Case report and discussion.
  
  
  METHODS
  Endocrine unit of a tertiary hospital.
  
  
  METHODS
  A 30-year-old male patient with BBS.
  
  
  METHODS
  Clinical evaluation, fine-needle aspiration of the testes, hormonal, cytogenetic, and pathologic evaluation.
  
  
  METHODS
  Serum gonadotropins and testosterone levels and presence of spermatogenesis in testicular aspirate.
  
  
  RESULTS
  Serum testosterone and gonadotropin levels were within the normal adult male range. Testicular aspirates showed spermatogenic cells of all series, including numerous spermatozoa and a few intact seminiferous tubules. The overall picture appeared to be consistent with normal spermatogenesis.
  
  
  CONCLUSIONS
  This is the first case of reversal of hypogonadotrophic hypogonadism in a male patient with BBS. Clinicians should look for such reversal in other patients with hypogonadotrophic hypogonadism and give appropriate prognosis.
authors.affiliation: Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Ankush
authors.initials: A
authors.lastname: Desai
authors.forename: Onkar
authors.initials: O
authors.lastname: Jha
authors.forename: Venkateswaran
authors.initials: V
authors.lastname: Iyer
authors.forename: Rima
authors.initials: R
authors.lastname: Dada
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Nikhil
authors.initials: N
authors.lastname: Tandon