Succinobucol: review of the metabolic, antiplatelet and cardiovascular effects.
BACKGROUND
Succinobucol (AGI-1067) was developed as a probucol derivative with anti-inflammatory and antioxidant properties. It has undergone Phase III clinical trials to determine its place in the treatment of atherosclerotic disease.


OBJECTIVE
This paper reviews the available history, pharmacology and preclinical and clinical trial data of succinobucol.


METHODS
Data were compiled following review of publications indexed in Medline and International Pharmaceutical Abstracts, industry media releases and relevant bibliographies.


CONCLUSIONS
In preclinical studies, succinobucol exhibited antioxidant, anti-inflammatory, antihyperglycemic and antiplatelet properties; however, these effects have not resulted in a reduction in cardiovascular clinical end points in clinical trials. Although proposed antihyperglycemic effects are being investigated, safety concerns and lack of clear cardiovascular benefit may limit its clinical use as an antihyperglycemic agent.
Muldrew
Kendrea M
KM
University of Arkansas for Medical Sciences, College of Pharmacy, Little Rock, AR 72205, USA.
Franks
Amy M
AM