title: Long-term small molecule and protein elution from TiO2 nanotubes.
abstract: In this study, TiO(2) nanotubes of various dimensions were used to elute albumin, a large protein molecule, as well as sirolimus and paclitaxel, common small molecule drugs. The nanotubes controlled small molecule diffusion for weeks and large molecule diffusion for a month. Drug eluted from the nanotubes was bioactive and decreased cell proliferation in vitro. Elution kinetics was most profoundly affected by tube height. This study demonstrates that TiO(2) nanotubes may be a promising candidate for a drug-eluting implant coating.
authors.affiliation: Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, California 94158-2330, USA.
authors.forename: Lily
authors.initials: L
authors.lastname: Peng
authors.forename: Adam D
authors.initials: AD
authors.lastname: Mendelsohn
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: LaTempa
authors.forename: Sorachon
authors.initials: S
authors.lastname: Yoriya
authors.forename: Craig A
authors.initials: CA
authors.lastname: Grimes
authors.forename: Tejal A
authors.initials: TA
authors.lastname: Desai