title: Development of vitiligo during melanoma treatment with a novel survivin inhibitor: a case report and review of the literature.
abstract: BACKGROUND
  The development of vitiligo has been associated with an improved clinical response in melanoma patients.
  
  
  METHODS
  We report a case of vitiligo associated with a novel antisurvivin drug and review the literature to determine the pathogenesis of vitiligo occurring during melanoma treatment.
  
  
  RESULTS
  A 78-year-old man with stage IV malignant melanoma developed vitiligo after the first therapeutic cycle of a novel antisurvivin drug. Although his vitiligo remained static, his melanoma continued to progress and he died in 8 months. A review of the literature demonstrates a relationship between vitiligo development and improved clinical response in many melanoma cases treated with immunotherapy; however, the relationship may depend on the type of treatment.
  
  
  CONCLUSIONS
  Understanding complex immune responses in vitiliginous skin and melanoma sites is important in order to interpret the development of vitiligo occurring during melanoma treatment.
authors.affiliation: Department of Dermatology and Division of Medical Oncology, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado 80010-7163, USA. mayumi.fujita@ucdenver.edu
authors.forename: Mayumi
authors.initials: M
authors.lastname: Fujita
authors.forename: Whitney A
authors.initials: WA
authors.lastname: High
authors.forename: Shabnam
authors.initials: S
authors.lastname: Asgari
authors.forename: Karl D
authors.initials: KD
authors.lastname: Lewis
authors.forename: Rene
authors.initials: R
authors.lastname: Gonzalez