title: Life-threatening infection due to community-acquired methicillin-resistant Staphylococcus aureus: case report and review.
abstract: We report an unusual case of serious, multifocal, invasive infection due to community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in a 10-year-old girl with favorable outcome. The child manifested femoral osteomyelitis, pyomyositis, deep femoral vein thrombosis, pneumonia, encephalopathy, and disturbances of almost all organs. She remained in a critical condition for a week. Fever persisted for 6 weeks and acute phase reactants remained increased for 6 months, necessitating a 7-month antistaphylococcal therapy with a glycopeptide and clindamycin. This led to resolution of infection-associated problems during the subsequent 36 months of follow-up. CA-MRSA strain isolated from the patient harbored both staphylococcal chromosomal cassette type IV (SCCmec type IV) and Panton-Valentine leukocidin genes. A literature review of serious CA-MRSA infections indicated that only a small minority of published cases had favorable outcome.
authors.affiliation: 3rd Department of Pediatrics, Aristotle University School of Medicine, Hippokration Hospital, Konstantinoupoleos 49, 546 42 Thessaloniki, Greece.
authors.forename: Kalomoira
authors.initials: K
authors.lastname: Kefala-Agoropoulou
authors.forename: Efthimia
authors.initials: E
authors.lastname: Protonotariou
authors.forename: Danai
authors.initials: D
authors.lastname: Vitti
authors.forename: Sofia
authors.initials: S
authors.lastname: Sarafidou
authors.forename: Athanasia
authors.initials: A
authors.lastname: Anastasiou
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Kollios
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Roilides