Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis.
The stem bark of Phoebe grandis afforded one new oxoproaporphine; (-)-grandine A (1), along with six known isoquinoline alkaloids: (-)-8,9-dihydrolinearisine (2), boldine, norboldine, lauformine, scortechiniine A and scortechiniine B. In addition to that of the new compound, complete 1H- and 13C-NMR data of the tetrahydroproaporphine (-)-8,9-dihydrolinearisine (2) is also reported. The alkaloids' structures were elucidated primarily by means of high field 1D- and 2D-NMR and HRMS spectral data.
Mukhtar
Mat Ropi
MR
Centre for Natural Products and Drug Discovery, Block D, Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. matropi@um.edu.my
Aziz
Ahmad Nazif
AN
Thomas
Noel F
NF
Hadi
A Hamid A
AH
Litaudon
Marc
M
Awang
Khalijah
K