The conserved sporulation protein YneE inhibits DNA replication in Bacillus subtilis.
Cells of Bacillus subtilis triggered to sporulate under conditions of rapid growth undergo a marked decrease in chromosome copy number, which was partially relieved by a mutation in the sporulation-induced gene yneE. Cells engineered to express yneE during growth were impaired in viability and produced anucleate cells. We conclude that YneE is an inhibitor of DNA replication.
Rahn-Lee
Lilah
L
Department of Molecular and Cellular Biology, Harvard University, 16 Divinity Ave., Cambridge, MA 02138, USA.
Gorbatyuk
Boris
B
Skovgaard
Ole
O
Losick
Richard
R