title: Mutation-prone points in KCNQ.
abstract: BACKGROUND
  KCNQ channels play important roles in controlling membrane excitability. A reduction in KCNQ channel activity due to genetic mutation is responsible for various human diseases, including arrhythmia.
  
  
  METHODS
  A combined bioinformatics analysis was performed to study the positions that are at risk for mutation within the amino acid sequence of KCNQ. A new bioinformatics tool, namely GlobPlot, was used.
  
  
  RESULTS
  According to the present study, the positions that are resistant to mutation are predicted.
  
  
  CONCLUSIONS
  Several mutation-prone positions within the KCNQ sequence are reported.
authors.affiliation: Wiwanitkit House, Bangkhae, Bangkok, Thailand.
authors.forename: Viroj
authors.initials: V
authors.lastname: Wiwanitkit