title: Population based prostate cancer screening in north Mexico reveals a high prevalence of aggressive tumors in detected cases.
abstract: BACKGROUND
  Prostate Cancer (PCa) is the second most frequent neoplasia in men worldwide. Previous reports suggest that the prevalence of PCa in Hispanic males is lower than in Africans (including communities with African ancestry) and Caucasians, but higher than in Asians. Despite these antecedents, there are few reports of open population screenings for PCa in Latin American communities. This article describes the results of three consecutive screenings in the urban population of Monterrey, Mexico.
  
  
  METHODS
  After receiving approval from our University Hospital's Internal Review Board (IRB), the screening was announced by radio, television, and press, and it was addressed to male subjects over 40 years old in general. Subjects who consented to participate were evaluated at the primary care clinics of the University Health Program at UANL, in the Metropolitan area of Monterrey. Blood samples were taken from each subject for prostate specific antigen (PSA) determination; they underwent a digital rectal examination (DRE), and were subsequently interviewed to obtain demographic and urologic data. Based on the PSA (>4.0 ng/ml) and DRE results, subjects were appointed for transrectal biopsy (TRB).
  
  
  RESULTS
  A total of 973 subjects were screened. Prostate biopsy was recommended to 125 men based on PSA values and DRE results, but it was performed in only 55 of them. 15 of these biopsied men were diagnosed with PCa, mostly with Gleason scores > or = 7.
  
  
  CONCLUSIONS
  Our results reflect a low prevalence of PCa in general, but a high occurrence of high grade lesions (Gleason > or = 7) among patients that resulted positive for PCa. This observation remarks the importance of the PCa screening programs in our Mexican community and the need for strict follow-up campaigns.
authors.affiliation: School of Medicine and University Hospital, Universidad Autonoma de Nuevo Leon, Monterrey, Mexico. laurogomez@hotmail.com
authors.forename: Lauro S
authors.initials: LS
authors.lastname: Gomez-Guerra
authors.forename: Margarita L
authors.initials: ML
authors.lastname: Martinez-Fierro
authors.forename: Valeria
authors.initials: V
authors.lastname: Alcantara-Aragon
authors.forename: Rocio
authors.initials: R
authors.lastname: Ortiz-Lopez
authors.forename: Rebeca T
authors.initials: RT
authors.lastname: Martinez-Villarreal
authors.forename: Idelma B
authors.initials: IB
authors.lastname: Morales-Rodriguez
authors.forename: Raquel
authors.initials: R
authors.lastname: Garza-Guajardo
authors.forename: Marco A
authors.initials: MA
authors.lastname: Ponce-Camacho
authors.forename: Augusto
authors.initials: A
authors.lastname: Rojas-Martinez