3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.
Vu
An T
AT
Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
Cohn
Stephen T
ST
Terefenko
Eugene A
EA
Moore
William J
WJ
Zhang
Puwen
P
Mahaney
Paige E
PE
Trybulski
Eugene J
EJ
Goljer
Igor
I
Dooley
Rebecca
R
Bray
Jenifer A
JA
Johnston
Grace H
GH
Leiter
Jennifer
J
Deecher
Darlene C
DC