Liaison amid disorder: non-native interactions may underpin long-range coupling in proteins.
A lattice-model study of double-mutant cycles published in BMC Structural Biology underscores how interactions in non-native conformations can lead to thermodynamic coupling between distant residues in globular proteins, adding to recent advances in delineating the often crucial roles played by disordered conformational ensembles in protein behavior.
Chan
Hue Sun
HS
Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, Ontario, Canada. chan@arrhenius.med.toronto.edu
Zhang
Zhuqing
Z