Treated depression in adolescents: predictors of outcome at 28 weeks.
BACKGROUND
There is great heterogeneity of clinical presentation and outcome in paediatric depression.


OBJECTIVE
To identify which clinical and environmental risk factors at baseline and during treatment predicted major depression at 28-week follow-up in a sample of adolescents with depression.


METHODS
One hundred and ninety-two British adolescents with unipolar major depression were enrolled in a randomised controlled trial (the Adolescent Depression Antidepressants and Psychotherapy Trial, ADAPT). Participants were treated for 28 weeks with routine psychosocial care and selective serotonin reuptake inhibitors (SSRIs), with half also receiving cognitive-behavioural therapy (CBT). Full clinical and demographic assessment was carried out at baseline and 28 weeks.


RESULTS
Depression at 28 weeks was predicted by the additive effects of severity, obsessive-compulsive disorder and suicidal ideation at entry together with presence of at least one disappointing life event over the follow-up period.


CONCLUSIONS
Clinicians should assess for severity, suicidality and comorbid obsessive-compulsive disorder at presentation and should monitor closely for subsequent life events during treatment.
Wilkinson
Paul
P
Developmental Psychiatry Section, University of Cambridge, Douglas House, 18b Trumpington Road, Cambridge CB2 8AH, UK. pow12@cam.ac.uk
Dubicka
Bernadka
B
Kelvin
Raphael
R
Roberts
Chris
C
Goodyer
Ian
I