title: Lack of association between neuropeptide S receptor 1 gene (NPSR1) and eczema in five European populations.
abstract: Eczema is often associated with development of allergic asthma. The Neuropeptide S Receptor 1 (NPSR1) gene has previously been associated with asthma and elevated serum IgE levels. The aim of this study was to investigate a potential association between the NPSR1 gene and eczema in patients and healthy individuals from five different populations in Western Europe, in total 6275 individuals. Seven single nucleotide polymorphisms previously associated with allergic asthma were genotyped. The protein expression of NPSR1 in the skin was studied using immunohistochemistry in six eczema patients and eight healthy individuals. No association was found be tween eczema and the seven single nucleotide polymor phisms in NPSR1 in any of the populations, either independently or in combinations. In addition, no difference was detected in epidermal NPSR1 expression between eczema patients and healthy individuals. These results strongly suggest that NPSR1 is not involved in the pathogenesis of eczema.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. elisabeth.ekelund@ki.se
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Ekelund
authors.forename: Maria
authors.initials: M
authors.lastname: Bradley
authors.forename: Stephan
authors.initials: S
authors.lastname: Weidinger
authors.forename: Dragan L
authors.initials: DL
authors.lastname: Jovanovic
authors.forename: Catharina
authors.initials: C
authors.lastname: Johansson
authors.forename: Cecilia M
authors.initials: CM
authors.lastname: Lindgren
authors.forename: Antonia
authors.initials: A
authors.lastname: Todorova
authors.forename: Thilo
authors.initials: T
authors.lastname: Jakob
authors.forename: Thomas
authors.initials: T
authors.lastname: Illig
authors.forename: Erika
authors.initials: E
authors.lastname: von Mutius
authors.forename: Charlotte
authors.initials: C
authors.lastname: Braun-Fahrländer
authors.forename: Gert
authors.initials: G
authors.lastname: Doekes
authors.forename: Josef
authors.initials: J
authors.lastname: Riedler
authors.forename: Annika
authors.initials: A
authors.lastname: Scheynius
authors.forename: Göran
authors.initials: G
authors.lastname: Pershagen
authors.forename: Ingrid
authors.initials: I
authors.lastname: Kockum
authors.forename: Juha
authors.initials: J
authors.lastname: Kere