title: Evolving spectrum and incidence of non-AIDS-defining malignancies.
abstract: OBJECTIVE
  Non-AIDS defining cancer (NADC) has emerged as an important cause of morbidity and mortality in the HIV-infected population. Insight into the incidence, spectrum, risk factors, management, and outcome of these cancers has continued to emerge. The recent literature on this topic is reviewed.
  
  
  RESULTS
  Several recent studies have explored the shifting spectrum of NADC in both developed and underdeveloped regions of the world. Investigators have shown only a minor difference in the geographic spectrum of NADC. Although several NADC have continued to occur at rates significantly higher than expected, a noticeable decline was observed in other cancers despite antiretroviral therapy. Factors other than HIV and immunosuppression proved to be important in the risk, treatment response, and outcome of these neoplasms. Studies dealing with the management of several NADC were published, including the role of highly active antiretroviral therapy (HAART).
  
  
  CONCLUSIONS
  An increased overall relative risk of developing NADC continues to be reported in the HIV-infected population worldwide. The development of NADC appears to be multifactorial. Although control of HIV viremia has proven to be beneficial, the impact of HAART on NADC incidence rates and survival is not uniform. Further effort is needed to resolve the direct and indirect effects of HIV on NADC in order to guide effective prevention and treatment strategies of these malignancies.
authors.affiliation: Department of Pathology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.
authors.forename: Liron
authors.initials: L
authors.lastname: Pantanowitz
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Dezube