title: Propofol concentration in exhaled air and arterial plasma in mechanically ventilated patients undergoing cardiac surgery.
abstract: BACKGROUND
  Measuring propofol concentration in plasma (c(P)PL) and in exhaled alveolar gas (c(P)G) during constant infusion provides information about their respective time courses. In the present study, we compared these time courses in patients undergoing cardiac surgery from the beginning of propofol anaesthesia until eye opening upon awakening.
  
  
  METHODS
  The c(P)G was measured before, during, and after continuous infusion of propofol for general anaesthesia in 12 patients at two randomly allocated doses (3 or 6 mg kg(-1) h(-1)). Gas samples were collected on Tenax tubes. After thermodesorption, c(P)G was measured by gas chromatography mass spectrometry. Simultaneously with exhaled gas, arterial blood was sampled for measuring c(P)PL by reversed-phase high-performance liquid chromatography with fluorescence detection. In order to compare the time courses of c(P)PL and c(P)G as dimensionless values directly, each gas and plasma value was normalized by relating it to the corresponding value at the end of the initial infusion after 40 min.
  
  
  RESULTS
  The c(P)G ranged between 2.8 and 22.5 ppb, whereas the corresponding c(P)PL varied between 0.3 and 3.3 microg ml(-1). Normalized concentration values showed a delayed increase in c(P)G compared with c(P)PL under constant propofol infusion before the onset of cardiopulmonary bypass, and a delayed decrease after stopping the propofol at the end of anaesthesia.
  
  
  CONCLUSIONS
  Propofol can be measured in exhaled gas from the beginning until the end of propofol anaesthesia. The different time courses of c(P)PL and c(P)G have to be considered when interpreting c(P)G.
authors.affiliation: Department of Anaesthesiology, University of Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany. martin_grossherr@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Grossherr
authors.forename: A
authors.initials: A
authors.lastname: Hengstenberg
authors.forename: T
authors.initials: T
authors.lastname: Meier
authors.forename: L
authors.initials: L
authors.lastname: Dibbelt
authors.forename: B W
authors.initials: BW
authors.lastname: Igl
authors.forename: A
authors.initials: A
authors.lastname: Ziegler
authors.forename: P
authors.initials: P
authors.lastname: Schmucker
authors.forename: H
authors.initials: H
authors.lastname: Gehring