title: Safety and efficacy of mixing cetrorelix with follitropin alfa: a randomized study.
abstract: OBJECTIVE
  To assess the safety and efficacy of mixing cetrorelix with follitropin alfa (rFSH) in assisted reproductive technology.
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  An IVF center in a teaching hospital.
  
  
  METHODS
  One hundred forty patients undergoing intracytoplasmic sperm injection were randomized into mixed (M) or separate (S) injection groups.
  
  
  METHODS
  In the M group, rFSH and cetrorelix were mixed immediately before administration, whereas in the S group, rFSH and cetrorelix were administered separately.
  
  
  METHODS
  The primary efficacy end point was the incidence of premature LH surge. The secondary efficacy endpoints included estradiol levels on the day of hCG injection, numbers of oocytes obtained, implantation, and ongoing pregnancy rates. The safety endpoints included ovarian hyperstimulation syndrome, and adverse events related to injections including local tolerability.
  
  
  RESULTS
  Excluding eight patients who dropped out of the study, there were 66 patients in each group for analysis. Patients in the M group received significantly fewer injections than patients in the S group (9.1 vs. 13.9). Other outcome parameters, including incidences of premature LH surge, numbers of oocytes retrieved, fertilization, implantation, and ongoing pregnancy rates were similar between the two groups.
  
  
  CONCLUSIONS
  Cetrorelix and rFSH can be mixed together without compromising their reported safety and efficacy. This observation is in line with the reported safety and efficacy profile of the products listed in their current package inserts.
authors.affiliation: Department of Obstetrics and Gynecology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, Republic of China.
authors.forename: Yu-Hung
authors.initials: YH
authors.lastname: Lin
authors.forename: Yeong-Ray
authors.initials: YR
authors.lastname: Wen
authors.forename: Yuanmay
authors.initials: Y
authors.lastname: Chang
authors.forename: Kok-Min
authors.initials: KM
authors.lastname: Seow
authors.forename: Bih-Chwen
authors.initials: BC
authors.lastname: Hsieh
authors.forename: Jiann-Loung
authors.initials: JL
authors.lastname: Hwang
authors.forename: Chii-Ruey
authors.initials: CR
authors.lastname: Tzeng