title: Identification of a receptor for activated protein kinase C1 (Pm-RACK1), a cellular gene product from black tiger shrimp (Penaeus monodon) interacts with a protein, VP9 from the white spot syndrome virus.
abstract: A gene encoding a receptor for activated protein kinase C1 homolog has been isolated from the shrimp, Penaeus monodon (Pm-RACK1). The full length Pm-RACK1 cDNA has 957 bp, and an open reading frame encoding a protein of 318 amino acid residues. The protein contains seven WD40 repeats and shares approximately 78% identity with vertebrate RACK1. In adult shrimp, Pm-RACK1 transcripts were detected in all tissues. During WSSV infection, Pm-RACK1 was upregulated in hepatopancreas, stomach and hemocytes. We identified Pm-RACK1 as a specific cellular target protein for VP9, a nonstructural protein of WSSV. The interaction of these two proteins may be involved in mediating intracellular VP9 functions.
authors.affiliation: Center for Genomics and Bioinformatics Research, Faculty of Science, Prince of Songkla University, 15 Karnjanavanit Road, Songkhla 90110, Thailand. tonganunt@yahoo.com
authors.forename: Moltira
authors.initials: M
authors.lastname: Tonganunt
authors.forename: Netnapa
authors.initials: N
authors.lastname: Saelee
authors.forename: Wilaiwan
authors.initials: W
authors.lastname: Chotigeat
authors.forename: Amornrat
authors.initials: A
authors.lastname: Phongdara