title: Decrease of renal function due to warm ischemia after laparoscopic partial nephrectomy: evaluation using 99mTc-DMSA renal scintigraphy.
abstract: BACKGROUND
  The purpose of this study is, using technetium-99m-dimercaptosuccinic acid ((99m)Tc-DMSA), to evaluate the decrease of renal function caused by warm ischemia.
  
  
  METHODS
  The (99m)Tc-DMSA scan was performed before and 1, 3 and 6 months after the operation for 19 consecutive patients. The patients were divided into three groups by warm ischemic time (group A: <or=40 min, B: >40 min intersection <or=60 min, C: >60 min). Renal function of the unresected part was defined as the uptake to unresected part relative to the uptake to the contralateral kidney. The reduction of renal function was expressed as a ratio of the function after the surgery divided by function before the surgery and was compared between the three groups.
  
  
  RESULTS
  The reduction in group C after 1 and 3 months tended to be greater than that in group A or B, although not reaching statistical significance (one-way ANOVA test, 1 month: p = 0.15 and 3 months: p = 0.13). There was a significant difference in reduction of renal function between the three groups after 6 months (one-way ANOVA test, p = 0.02). The Scheffé test showed a statistical significance between groups A and C (p < 0.05).
  
  
  CONCLUSIONS
  Renal function calculated by (99m)Tc-DMSA shows that prolonged ischemic time causes significant damage to the kidney.
authors.affiliation: Department of Radiology, Division of Medical Intelligence and Informatics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan.
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tachikake
authors.forename: Masanobu
authors.initials: M
authors.lastname: Shigeta
authors.forename: Koji
authors.initials: K
authors.lastname: Mita
authors.forename: Kazushi
authors.initials: K
authors.lastname: Marukawa
authors.forename: Tsuguru
authors.initials: T
authors.lastname: Usui
authors.forename: Katsuhide
authors.initials: K
authors.lastname: Ito