title: Dietary conjugated linoleic acid induces tissue-specific lipoprotein lipase mRNA modulation in high-sucrose-fed mice.
abstract: OBJECTIVE
  To delineate the hypotriglyceridemic effect of conjugated linoleic acid (CLA) in mice, the effect of this fatty acid on lipoprotein lipase (LPL) and apolipoprotein C-III (ApoCIII) mRNA accumulation in muscle, adipose and liver tissue was studied.
  
  
  METHODS
  CD-1 mice were housed in groups of 6 and randomized to one of three experimental diets for 3 weeks: SUC: 65% sucrose by weight; CLA: 1% CLA oil (34.4% c9,t11; 35.1% t10,c12 and 4.1% other conjugated isomers) and 65% sucrose, and DEX: 65% dextrose, as a control.
  
  
  RESULTS
  LPL mRNA levels in muscle tissue were increased in the DEX group and in the CLA group (240% increase) compared with the SUC group. In contrast, LPL mRNA levels were 81% lower in epididymal adipose tissue from the CLA group compared with the SUC group. There was no effect of dietary treatments on ApoCIII mRNA accumulation in the liver.
  
  
  CONCLUSIONS
  These data suggest that dietary CLA may induce partitioning of circulating triglycerides to muscle tissue, preventing their accumulation in adipocytes.
authors.affiliation: Department of Nutrition and Metabolism, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, México.
authors.forename: Lyssia
authors.initials: L
authors.lastname: Castellanos-Tapia
authors.forename: Gloria
authors.initials: G
authors.lastname: Yepiz-Plasencia
authors.forename: Silvia Y
authors.initials: SY
authors.lastname: Moya-Camarenaa