Effects of a synbiotic product on blood antioxidative activity in subjects colonized with Helicobacter pylori.
OBJECTIVE
To evaluate the impact of the consumption of a synbiotic product on the antioxidative activity markers of blood in asymptomatic H. pylori-colonized persons.


RESULTS
Fifty-three healthy adult volunteers without gastric symptoms participated in a randomized, double-blind placebo-controlled study. The crossover consumption of the enterocoated capsules containing antioxidative Lactobacillusfermentum ME-3, Lact. paracasei 8700:2 and Bifidobacterium longum 46 with Raftilose P95 lasted for 3 weeks and did not change the H. pylori colonization. In H. pylori-positive subjects the sera values of total antioxidative status (TAS) were significantly lower compared to H. pylori-negative subjects (0.97 vs 1.05 mmol l(-1), P = 0.008). After the consumption of the synbiotic, TAS values (0.97 vs 1.03 mmol l(-1), P = 0.004) increased, while the ratio between oxidized and reduced glutathione (0.035 vs 0.030, P = 0.016) decreased in H. pylori-positive subjects.


CONCLUSIONS
The consumption of a synbiotic containing an antioxidative probiotic strain improved the reduced systemic antioxidative activity in H. pylori-colonized asymptomatic subjects.


CONCLUSIONS
A synbiotic product containing an antioxidative probiotic strain may be useful in the reduction of systemic oxidative stress in H. pylori infection.
Hütt
P
P
Department of Microbiology, Medical Faculty, University of Tartu, Tartu, Estonia. pirje.hutt@ut.ee
Andreson
H
H
Kullisaar
T
T
Vihalemm
T
T
Unt
E
E
Kals
J
J
Kampus
P
P
Zilmer
M
M
Mikelsaar
M
M