title: A prospective study of salivary gland function in lymphoma patients receiving head and neck irradiation.
abstract: OBJECTIVE
  To determine the radiation dose-response relationship on salivary dysfunction and quality of life (QOL) over time in patients with lymphoma receiving radiation therapy (RT) to the head and neck (H&N).
  
  
  METHODS
  We conducted a prospective study on salivary-gland function in lymphoma patients receiving RT to the H&N. Fifteen patients were enrolled on the study. Dose-volume histograms and mean doses to the salivary glands were generated. Radiation-related toxicities and H&N-specific QOL were assessed before treatment and at prespecified time points posttreatment. Factors predicting a decrement in QOL were explored using Fisher's exact test.
  
  
  RESULTS
  During RT, 47% of patients experienced Grade >or= 2 acute toxicity of the salivary gland, mucous membrane, or both. QOL scores improved over time, but up to one third of patients continued to have persistent oral symptoms at 2 years. At 6 months, a mean dose to at least one of the parotids of > 31 Gy was significantly associated with persistent dry mouth (100% vs. 17%, p = 0.02) and sticky saliva (100% vs. 25%, p = 0.04); a mean dose of > 11 Gy to the minor salivary glands was significantly associated with persistent sticky saliva (100% vs. 25%, p = 0.04), although the difference was no longer significant at 1 year.
  
  
  CONCLUSIONS
  Limiting the mean parotid dose to <or= 31 Gy and mean minor salivary gland dose to <or= 11 Gy in lymphoma patients treated to the H&N may help reduce the risk of subacute xerostomia.
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Neesha A
authors.initials: NA
authors.lastname: Rodrigues
authors.forename: Leah
authors.initials: L
authors.lastname: Killion
authors.forename: Gail
authors.initials: G
authors.lastname: Hickey
authors.forename: Barbara
authors.initials: B
authors.lastname: Silver
authors.forename: Chrystalla
authors.initials: C
authors.lastname: Martin
authors.forename: Mary Ann
authors.initials: MA
authors.lastname: Stevenson
authors.forename: Peter M
authors.initials: PM
authors.lastname: Mauch
authors.forename: Andrea K
authors.initials: AK
authors.lastname: Ng