title: Pentanol derivatives from basidiomycete Catathelasma imperiale and their 11beta-hydroxysteroid dehydrogenases inhibitory activity.
abstract: Five new secondary metabolites derived from pentanol, namely catathelasmols A-E (1-5), were isolated from the fruiting bodies of the basidiomycete Catathelasma imperiale. Their structures were elucidated on the basis of spectroscopic analysis, and the absolute configurations were determined by computational chemistry. Compounds 3, 4 and 5 showed inhibitory activities against two isozymes of 11-hydroxysteroid dehydrogenases (11-HSD1 and 11-HSD2), with IC(50) values of 28.7-62.3 microg ml(-1) (human 11-HSD1), 30.4-149.2 microg ml(-1) (mouse 11-HSD1), 5.1-177 microg ml(-1) (human 11-HSD2) and 32.3-129.1 microg ml(-1) (mouse 11-HSD2), which catalyze the interconversion of cortisol and cortisone.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Zhang
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Hua-Jie
authors.initials: HJ
authors.lastname: Zhu
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Ji-Kai
authors.initials: JK
authors.lastname: Liu