Online ESI-MS analysis of reactions under high pressure.
A new approach for real-time mass spectrometric analysis and identification of intermediates in confined, pressurized vessels is presented. The high-pressure reaction media is depressurized, mixed with a solvent, and fed directly to the atmospheric pressure electrospray ionization source of a tandem mass spectrometer. The method was applied to track product evolution for the dehydration of hydroxenin monoacetate, a commercially, important vitamin A precursor, and for the hydrogenation of 5-norbornene-2-carbonitrile with Pd/CaCO(3) as catalyst. Faster access but comparable results as by conventional off-line methods were obtained in every case.
Paz-Schmidt
Roberto A
RA
Institute of Organic Chemistry and Biochemistry, University of Freiburg, Albertstrasse 21, D-79104, Freiburg im Breisgau, Germany.
Bonrath
Werner
W
Plattner
Dietmar A
DA