title: The preparation of 2,6-disubstituted pyridinyl phosphine oxides as novel anti-cancer agents.
abstract: A series of 2,6-dimethoxylpyridinyl phosphine oxides have been synthesized and examined for their antitumor activity. 2,6-Dimethoxy-3-phenyl-4-diphenylphosphinoylpyridine 2 has been employed as the lead compound for this study. We found out that the presence of phosphine oxide on the 2,6-dimethoxylpyridine ring is important for the antitumor activity; the presence of bromine on this core leads to a further enhancement of its antitumor activity. This is the first reported work on the antitumor activity of the 2,6-dimethoxy-3,5-dibromopyridinyl phosphine oxide 5b towards MDAMB-231 breast cancer and SKHep-1 hepatoma cell lines.
authors.affiliation: Department of Applied Biology and Chemical Technology, Institute of Textiles and Clothing, Hong Kong Polytechnic University, Hong Kong, China. bcjoelam@inet.polyu.edu.hk
authors.forename: Kim Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Marcus Chun Wah
authors.initials: MC
authors.lastname: Yuen
authors.forename: Chi Wai
authors.initials: CW
authors.lastname: Kan
authors.forename: Penni
authors.initials: P
authors.lastname: Chan
authors.forename: Lijin
authors.initials: L
authors.lastname: Xu
authors.forename: Weijun
authors.initials: W
authors.lastname: Tang
authors.forename: Chung Hin
authors.initials: CH
authors.lastname: Chui
authors.forename: Gregory Yin Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Raymond Siu Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Fung Yi
authors.initials: FY
authors.lastname: Lau
authors.forename: Cindy Sze Wai
authors.initials: CS
authors.lastname: Tong
authors.forename: Andrew Kit Wah
authors.initials: AK
authors.lastname: Chan
authors.forename: Paul Bo San
authors.initials: PB
authors.lastname: Lai
authors.forename: Stanton Hon Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Chor Hing
authors.initials: CH
authors.lastname: Cheng
authors.forename: Albert Sun Chi
authors.initials: AS
authors.lastname: Chan
authors.forename: Johnny Cheuk On
authors.initials: JC
authors.lastname: Tang