title: Impact of cadmium on aquatic bird Cairina moschata.
abstract: The impact on palmiped Cairina moschata of two levels of dietary cadmium (Cd) contamination (C1: 1 mg kg(-1) and C10: 10 mg kg(-1)) was investigated on liver gene expression by real-time PCR. Genes involved in mitochondrial metabolism, in antioxidant defences, detoxification and in DNA damage repair were studied. Metallothionein (MT) protein levels and Cd bioaccumulation were also investigated in liver, kidneys and muscle. Male ducks were subjected to three periods of exposure: 10, 20 and 40 days. Cd was mainly bioaccumulated in kidneys first and in liver. The concentrations in liver and kidneys appeared to reach a stable level at 20 days of contamination even if the concentrations in muscle still increased. Cd triggered the enhancement of mitochondrial metabolism, the establishment of antioxidant defences (superoxide dismutase Mn and Cu/Zn; catalase) and of DNA repair from 20 days of contamination. Discrepancies were observed in liver between MT protein levels and MT gene up-regulation. MT gene expression appeared to be a late hour biomarker.
authors.affiliation: IPREM-EEM (Institut Pluridisciplinaire de Recherche sur l'Environnement et les Matériaux, Equipe Environnement et Microbiologie), UMR 5254, IUT des Pays de l'Adour, Mont de Marsan Cedex, France. magali.lucia@etud.univ-pau.fr
authors.forename: Magali
authors.initials: M
authors.lastname: Lucia
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Andre
authors.forename: Patrice
authors.initials: P
authors.lastname: Gonzalez
authors.forename: Magalie
authors.initials: M
authors.lastname: Baudrimont
authors.forename: Karine
authors.initials: K
authors.lastname: Gontier
authors.forename: Regine
authors.initials: R
authors.lastname: Maury-Brachet
authors.forename: Stephane
authors.initials: S
authors.lastname: Davail