title: Prodigiosin biosynthesis gene cluster in the roseophilin producer Streptomyces griseoviridis.
abstract: Streptomyces griseoviridis 2464-S5 produces prodigiosin R1, a tripyrrole antibiotic, and roseophilin, a structurally related compound containing two pyrrole and one furan rings. A gene cluster for the biosynthesis of a prodigiosin was identified in S. griseoviridis. The cluster consisted of 24 open reading frames, including 21 genes (rphD-rphZ) homologous to prodigiosin biosynthesis genes in the red cluster in Streptomyces coelicolor A3(2). The expression of rphN in S. coelicolor lacking redN restored the production of prodigiosin.
authors.affiliation: Department of Medicinal and Life Science, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawasaki
authors.forename: Fumi
authors.initials: F
authors.lastname: Sakurai
authors.forename: Shun-ya
authors.initials: SY
authors.lastname: Nagatsuka
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hayakawa