title: Effects on executive function following damage to the prefrontal cortex in the rhesus monkey (Macaca mulatta).
abstract: Executive function is a term used to describe the cognitive processes subserved by the prefrontal cortex (PFC). An extensive body of work has characterized the effects of damage to the PFC in nonhuman primates, but it has focused primarily on the capacity of recognition and working memory. One limitation in studies of the functional parcellation of the PFC has been the absence of tests that assess executive function or its functional components. The current study used an adaptation of the Wisconsin Card Sorting Test, a classic test of frontal lobe and executive function in humans, to assess the effects of bilateral lesions in the dorsolateral PFC on executive function in the rhesus monkey (Macaca mulatta). The authors used the category set-shifting task, which requires the monkey to establish a pattern of responding to a specific category (color or shape) based on reward contingency, maintain that pattern of responding, and then shift to responding to a different category when the reward contingency changes. Rhesus monkeys with lesions of the dorsolateral PFC were impaired in abstraction, establishing a response pattern to a specific category and maintaining and shifting that response pattern on the category set-shifting task.
authors.affiliation: Department of Anatomy and Neurobiology, Boston University School of Medicine, 715 Albany Street, W-701, Boston, MA 02118, USA. tlmoore@bu.edu
authors.forename: Tara L
authors.initials: TL
authors.lastname: Moore
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Schettler
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Killiany
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Rosene
authors.forename: Mark B
authors.initials: MB
authors.lastname: Moss