Uterine smooth muscle tumor of uncertain malignant potential: a retrospective analysis.
OBJECTIVE
This retrospective study was designed to evaluate the clinicopathologic features and outcomes of a cohort of patients diagnosed with uterine smooth muscle tumor of uncertain malignant potential (STUMP) seen at a single institution.


METHODS
All patients diagnosed with uterine STUMP and seen between 1990 and 2005 at The University of Texas M. D. Anderson Cancer Center were identified using the institution's databases. Variables of interest included age at diagnosis, recurrence rate, and disease-free and overall survival.


RESULTS
Forty-one patients with uterine STUMP were identified and included in the study. The mean age at diagnosis was 43 years (range 25-75 years). The mean follow-up time was 45 months (range 1-171 months). Three patients (7.3%) had a recurrence during the follow-up period. One of the three patients who had recurrent disease was found to have a leiomyosarcoma at the time of recurrence. Recurrence rates were similar for women who underwent myomectomy and those who underwent hysterectomy. All three patients with recurrence were alive and disease-free at a mean follow-up time of 121 months.


CONCLUSIONS
Our results suggest that in this cohort of patients with uterine STUMP the recurrence rate was 7%. Recurrences can be in the form of STUMP or leiomyosarcoma.
Guntupalli
Saketh R
SR
Division of Gynecologic Oncology, Baylor College of Medicine, Houston, TX, USA.
Ramirez
Pedro T
PT
Anderson
Matthew L
ML
Milam
Michael R
MR
Bodurka
Diane C
DC
Malpica
Anais
A