Differential effects of valproic acid on growth, proliferation and metastasis in HTB5 and HTB9 bladder cancer cell lines.
High grade invasive bladder cancer is a leading cause of cancer deaths and treatment options are limited for this type of cancer. Recent studies have reported anticancer effects of valproic acid in many cancers and also in superficial bladder cancer. Acute valproic acid administration suppressed cell proliferation in a time- and dose-dependent manner in two muscle-invasive human bladder cancer cell lines (HTB5 and HTB9), with accompanying G1 phase cell cycle arrest. A significant decrease in colony formation ability and invasiveness was seen with valproic acid treatment though the effectiveness varied with cell type. Our results suggest a role for valproic acid in inhibiting growth and invasion of muscle-invasive bladder cancer.
Byun
Seok-Soo
SS
Department of Surgery, University of Colorado at Denver and Health Sciences Center, Aurora, 80045, USA.
Kim
Fernando J
FJ
Khandrika
Lakshmipathi
L
Kumar
Binod
B
Koul
Sweaty
S
Wilson
Shandra
S
Koul
Hari K
HK