title: Proximal tubular dysfunction associated with tenofovir and didanosine causing Fanconi syndrome and diabetes insipidus: a report of 3 cases.
abstract: We report 3 cases of patients with HIV/AIDS in whom Fanconi syndrome and nephrogenic diabetes insipidus developed secondary to use of an antiretroviral regimen containing tenofovir disoproxil fumarate and didanosine. These patients presented with a history of polydipsia, polyuria, weight loss, anorexia, and wasting. Interestingly, 1 patient was not taking protease inhibitors. This response is a well-documented yet uncommon complication of tenofovir use in the HIV population. We recommend continued monitoring for renal toxicity when using NRTI combination of tenofovir and didanosine.
authors.affiliation: Division of General Internal Medicine, Mayo Clinic, Jacksonville, Florida, USA.
authors.forename: Joan M
authors.initials: JM
authors.lastname: Irizarry-Alvarado
authors.forename: Jamie P
authors.initials: JP
authors.lastname: Dwyer
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Brumble
authors.forename: Salvador
authors.initials: S
authors.lastname: Alvarez
authors.forename: Julio C
authors.initials: JC
authors.lastname: Mendez