title: Coronavirus infection and hospitalizations for acute respiratory illness in young children.
abstract: There is only limited knowledge on the burden of disease due to both new (HCoV-NL63 and HKU-1) and previously discovered coronaviruses (OC43 and 229E) in children. Respiratory specimens and clinical data were prospectively collected in an active, population-based surveillance study over a 2-year period from children aged <5 years hospitalized with acute respiratory symptoms or fever. These samples were retrospectively tested by real-time RT-PCR for HCoV-NL63, HKU1, OC43, and 229E. Human coronaviruses (HCoVs) were identified in 2.2% of study children <2 years of age. Rates of HCoV-associated hospitalization per 10,000 were 10.2 (95% CI 4.3, 17.6), 4.2 (95% CI 1.9, 6.9), and 0 (95% CI 0, 3.7) in children aged <6 months, 6-23 months, and 24-59 months, respectively. Coronaviruses were identified in a modest number of hospitalized children.
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA. keipp.talbot@vanderbilt.edu
authors.forename: H Keipp B
authors.initials: HK
authors.lastname: Talbot
authors.forename: James E
authors.initials: JE
authors.lastname: Crowe
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Edwards
authors.forename: Marie R
authors.initials: MR
authors.lastname: Griffin
authors.forename: Yuwei
authors.initials: Y
authors.lastname: Zhu
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Weinberg
authors.forename: Peter G
authors.initials: PG
authors.lastname: Szilagyi
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Hall
authors.forename: Amy B
authors.initials: AB
authors.lastname: Podsiad
authors.forename: Marika
authors.initials: M
authors.lastname: Iwane
authors.forename: John V
authors.initials: JV
authors.lastname: Williams