title: Toxic dermatolysis, tissue necrosis and impaired wound healing due to sunitinib treatment leading to forefoot amputation.
abstract: Innovative treatment strategies in urologic oncology confront the treating physician with a new spectrum of adverse events. With growing understanding of underlying pathomechanisms, we need to identify contraindications against the use of certain antiproliferative drugs. The management of toxicities involves a multidisciplinary approach and thus, the exchange of experience across medical specialties is mandatory. We report a case of fulminant toxic dermatolysis, tissue necrosis and impaired wound healing resulting in the amputation of one forefoot after 6 days of treatment with sunitinib.
authors.affiliation: Department of Urology, University of Tubingen, Tubingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Feyerabend
authors.forename: D
authors.initials: D
authors.lastname: Schilling
authors.forename: C
authors.initials: C
authors.lastname: Wicke
authors.forename: A
authors.initials: A
authors.lastname: Stenzl