title: FTY720 Inhibits Tumor Necrosis Factor-alpha-Induced Proliferation and Extracellular Signal-Regulated Kinase Phosphorylation of Human Smooth Muscle Cells.
abstract: We investigated the effects of the sphingolipid FTY720 on tumor necrosis factor-alpha (TNF-alpha)-induced proliferation and signal transduction in human smooth muscle cells (SMC). We showed that clinically relevant concentrations of FTY720 inhibited TNF-alpha-induced SMC proliferation and extracellular signal-regulated kinase (ERK) phosphorylation. We concluded that FTY720 may be a useful drug to inhibit chronic vascular rejection.
authors.affiliation: INSERM U858/I2MR EQ 10 Artériosclérose et Artériosclérose de Greffe, CHU Rangueil, Toulouse, France.
authors.forename: T
authors.initials: T
authors.lastname: Böhler
authors.forename: N
authors.initials: N
authors.lastname: Kamar
authors.forename: L
authors.initials: L
authors.lastname: Etienne
authors.forename: S
authors.initials: S
authors.lastname: Galvani
authors.forename: C
authors.initials: C
authors.lastname: Canivet
authors.forename: M
authors.initials: M
authors.lastname: Thomsen
authors.forename: R
authors.initials: R
authors.lastname: Salvayre
authors.forename: A
authors.initials: A
authors.lastname: Nègre-Salvayre
authors.forename: L
authors.initials: L
authors.lastname: Rostaing
authors.forename: N
authors.initials: N
authors.lastname: Auge