title: Prostate cancer: sextant localization at MR imaging and MR spectroscopic imaging before prostatectomy--results of ACRIN prospective multi-institutional clinicopathologic study.
abstract: OBJECTIVE
  To determine the incremental benefit of combined endorectal magnetic resonance (MR) imaging and MR spectroscopic imaging, as compared with endorectal MR imaging alone, for sextant localization of peripheral zone (PZ) prostate cancer.
  
  
  METHODS
  This prospective multicenter study, conducted by the American College of Radiology Imaging Network (ACRIN) from February 2004 to June 2005, was institutional review board approved and HIPAA compliant. Research associates were required to follow consent guidelines approved by the Office for Human Research Protection and established by the institutional review boards. One hundred thirty-four patients with biopsy-proved prostate adenocarcinoma and scheduled to undergo radical prostatectomy were recruited at seven institutions. T1-weighted, T2-weighted, and spectroscopic MR sequences were performed at 1.5 T by using a pelvic phased-array coil in combination with an endorectal coil. Eight readers independently rated the likelihood of the presence of PZ cancer in each sextant by using a five-point scale-first on MR images alone and later on combined MR-MR spectroscopic images. Areas under the receiver operating characteristic curve (AUCs) were calculated with sextant as the unit of analysis. The presence or absence of cancer at centralized histopathologic evaluation of prostate specimens was the reference standard. Reader-specific receiver operating characteristic curves for values obtained with MR imaging alone and with combined MR imaging-MR spectroscopic imaging were developed. The AUCs were estimated by using Mann-Whitney statistics and appropriate 95% confidence intervals.
  
  
  RESULTS
  Complete data were available for 110 patients (mean age, 58 years; range, 45-72 years). MR imaging alone and combined MR imaging-MR spectroscopic imaging had similar accuracy in PZ cancer localization (AUC, 0.60 vs 0.58, respectively; P > .05). AUCs for individual readers were 0.57-0.63 for MR imaging alone and 0.54-0.61 for combined MR imaging-MR spectroscopic imaging.
  
  
  CONCLUSIONS
  In patients who undergo radical prostatectomy, the accuracy of combined 1.5-T endorectal MR imaging-MR spectroscopic imaging for sextant localization of PZ prostate cancer is equal to that of MR imaging alone.
authors.affiliation: Department of Radiology, Yale University School of Medicine, 333 Cedar St, PO Box 208042, New Haven, CT 06520, USA. jeffrey.weinreb@yale.edu
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Weinreb
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Blume
authors.forename: Fergus V
authors.initials: FV
authors.lastname: Coakley
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Wheeler
authors.forename: Jean B
authors.initials: JB
authors.lastname: Cormack
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Sotto
authors.forename: Haesun
authors.initials: H
authors.lastname: Cho
authors.forename: Akira
authors.initials: A
authors.lastname: Kawashima
authors.forename: Clare M
authors.initials: CM
authors.lastname: Tempany-Afdhal
authors.forename: Katarzyna J
authors.initials: KJ
authors.lastname: Macura
authors.forename: Mark
authors.initials: M
authors.lastname: Rosen
authors.forename: Scott R
authors.initials: SR
authors.lastname: Gerst
authors.forename: John
authors.initials: J
authors.lastname: Kurhanewicz