It takes two binding sites for calcineurin and NFAT to tango.
In a recent issue of Molecular Cell, Rodríguez et al. (2009) identified the NFAT LxVP motif binding site as the same composite surface formed by the two calcineurin subunits that is recognized by the cyclophilin-CsA and FKBP-FK506 complexes.
Liu
Jun O
JO
Department of Pharmacology, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA. joliu@jhu.edu
Nacev
Benjamin A
BA
Xu
Jing
J
Bhat
Shridhar
S