title: On the function and structure of synthetically modified porins.
abstract: The attachment of modulators to a trimeric porin ion channel was investigated (see picture of the trimer with a crown ether modulator (orange)). The interplay of modulator and protein is essential for the conformational heterogeneity of the hybrid channel. Single-site attachment in large pores is not sufficient to change the electrophysiological characteristics of the pores-such change requires additional noncovalent interactions or second-site attachments.
authors.affiliation: Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerwein-Strasse, 35032 Marburg, Germany.
authors.forename: Simon
authors.initials: S
authors.lastname: Reitz
authors.forename: Menekse
authors.initials: M
authors.lastname: Cebi
authors.forename: Philipp
authors.initials: P
authors.lastname: Reiss
authors.forename: Gregor
authors.initials: G
authors.lastname: Studnik
authors.forename: Uwe
authors.initials: U
authors.lastname: Linne
authors.forename: Ulrich
authors.initials: U
authors.lastname: Koert
authors.forename: Lars-Oliver
authors.initials: LO
authors.lastname: Essen