title: Copper-catalyzed direct C arylation of heterocycles with aryl bromides: discovery of fluorescent core frameworks.
abstract: A window of opportunity: A general copper-catalyzed C-H bond-activation path allows arylation of heterocycles with a wide range of aryl bromides (see scheme). The reaction shows excellent regioselectivity and exhibits good functional group tolerance. The 8-aryl xanthines exhibit fluorescence in a variety of solvents and show promise as reagents for biological imaging.
authors.affiliation: Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, West China Medical School, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
authors.forename: Dongbing
authors.initials: D
authors.lastname: Zhao
authors.forename: Wenhai
authors.initials: W
authors.lastname: Wang
authors.forename: Fei
authors.initials: F
authors.lastname: Yang
authors.forename: Jingbo
authors.initials: J
authors.lastname: Lan
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Ge
authors.initials: G
authors.lastname: Gao
authors.forename: Jingsong
authors.initials: J
authors.lastname: You