title: ATG16L1 T300A polymorphism and Crohn's disease susceptibility: evidence from 13,022 cases and 17,532 controls.
abstract: Many studies have reported the association between the autophagy-related 16-like 1 gene (ATG16L1) T300A polymorphism (rs2241880) and Crohn's disease (CD) susceptibility, but the results were inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A total of 24 studies including 13,022 cases and 17,532 controls were included in this meta-analysis. Logistic regression analysis indicated that the ATG16L1 T300A polymorphism was associated with CD risk in Caucasians (P < 0.01). The pooled estimations of OR(1) (GG vs. AA) and OR(2) (GA vs. AA) in Caucasian studies by Bayesian meta-analysis method was [1.87, 95% confidence interval (CI) 1.69-2.05] and (1.39, 95% CI 1.27-1.51), respectively. The mode of heritance of the G allele was most likely to be co-dominant in Caucasians. However, no significant association was found in Asians. This meta-analysis suggests that the G allele of ATG16L1 T300A is a low-penetrant gene for developing CD in Caucasians.
authors.affiliation: Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning, China.
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Zhang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Qiu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Wa-Li
authors.initials: WL
authors.lastname: Zhu
authors.forename: Chen
authors.initials: C
authors.lastname: Mao
authors.forename: Li-Guang
authors.initials: LG
authors.lastname: Zhu
authors.forename: Ming-Hua
authors.initials: MH
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Jian
authors.initials: J
authors.lastname: Shi