title: Surgical management of liver metastases from uveal melanoma: 16 years' experience at the Institut Curie.
abstract: BACKGROUND
  Uveal melanoma is characterised by a high prevalence of liver metastases and a poor prognosis.
  
  
  OBJECTIVE
  To review the evolving surgical management of this challenging condition at a single institution over a 16-year period.
  
  
  METHODS
  Between January 1991 and June 2007, among 3873 patients with uveal melanoma, 798 patients had liver metastases. We undertook a detailed retrospective review of their clinical records and surgical procedures. The data was evaluated with both uni- and multivariate statistical analysis for predictive survival indicators.
  
  
  RESULTS
  255 patients underwent surgical resection. The median interval between ocular tumour diagnosis and liver surgery was 68 months (range 19-81). Liver surgery was either microscopically complete (R0; n = 76), microscopically incomplete (R1; n = 22) or macroscopically incomplete (R2; n = 157). The median overall postoperative survival was 14 months, but increased to 27 months when R0 resection was possible. With multivariate analysis, four variables were found to independently correlate with prolonged survival: an interval from primary tumour diagnosis to liver metastases >24 months, comprehensiveness of surgical resection (R0), number of metastases resected (< or = 4) and absence of miliary disease.
  
  
  CONCLUSIONS
  Surgical resection, when possible, is able to almost double the survival and appears at present the optimal way of improving the prognosis in metastatic uveal melanoma. Advances in medical treatments will be required to further improve survival.
authors.affiliation: Department of Surgery, Institut Curie, 26 rue d'Ulm, 75248 Paris Cedex 05, France. pascale.mariani@curie.net
authors.forename: P
authors.initials: P
authors.lastname: Mariani
authors.forename: S
authors.initials: S
authors.lastname: Piperno-Neumann
authors.forename: V
authors.initials: V
authors.lastname: Servois
authors.forename: M G
authors.initials: MG
authors.lastname: Berry
authors.forename: T
authors.initials: T
authors.lastname: Dorval
authors.forename: C
authors.initials: C
authors.lastname: Plancher
authors.forename: J
authors.initials: J
authors.lastname: Couturier
authors.forename: C
authors.initials: C
authors.lastname: Levy-Gabriel
authors.forename: L
authors.initials: L
authors.lastname: Lumbroso-Le Rouic
authors.forename: L
authors.initials: L
authors.lastname: Desjardins
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon