title: Does prior training affect acute O₂ supply responses during exercise in Desaturator COPD patients?
abstract: BACKGROUND
  This study investigated the effects of a prior individualized training program (TP) on the response to acute oxygen supply during exercise in chronic obstructive pulmonary disease (COPD) patients showing exercise-induced desaturation.
  
  
  METHODS
  Twenty-two COPD patients (mean [SD] FEV1 = 52.1 [3]% predicted) who desaturated on exercise participated in a TP. Exercise tolerance while breathing compressed air or oxygen was assessed using a walking test (WT) before and after TP. Oxygen flow was individualized.
  
  
  RESULTS
  Before TP, acute oxygen supply improved mean exercise tolerance. But this response was heterogeneous as only 8 patients increased their walking distance with oxygen. TP improved exercise tolerance in the entire population. However, a greater affect of oxygen administration during exercise was not observed after TP. The response to oxygen again showed great disparity as only 6 patients increased their walking distance with oxygen after TP.
  
  
  CONCLUSIONS
  The response to oxygen supply during exercise varied among COPD patients. Moreover, despite the clinical benefits of TP, no cumulative effect of TP and oxygen supply was observed during exercise performance.
authors.affiliation: INSERM ERI25 <Muscle and Pathologies>, F-34295 Montpellier, France. Université Montpellier I, EA4202, F-34295 Montpellier, France. ddelample@yahoo.fr
authors.forename: Delphine
authors.initials: D
authors.lastname: Delample
authors.forename: Meritxell
authors.initials: M
authors.lastname: Sabate
authors.forename: Christian
authors.initials: C
authors.lastname: Préfaut
authors.forename: Fabienne
authors.initials: F
authors.lastname: Durand