title: Cerebral blood flow velocities in extremely low birth weight infants with hypotension and infants with normal blood pressure.
abstract: OBJECTIVE
  To determine whether extremely low birth weight (ELBW) infants with hypotension have similar cerebral hemodynamics when compared with control subjects with normal blood pressure. We hypothesized that ELBW infants with low or normal blood pressure have similar cerebral blood flow (CBF) velocity.
  
  
  METHODS
  In this case control study, CBF velocity (with Doppler ultrasound scanning), PCO2, and mean arterial blood pressure (MABP) were continuously monitored twice daily before intensive care procedures. If an infant became hypotensive (MABP < or = gestational age in weeks), additional monitoring was performed for 10 to 20 minutes, before treatment with dopamine. Thirty ELBW infants were enrolled (637 +/- 140 g, 24.2 +/- 1.1 weeks); 15 had hypotension, and 15 were gestational age/birth weight-matched control subjects with normal blood pressure. CBF velocity was compared by use of the Mann-Whitney U test.
  
  
  RESULTS
  The groups did not differ significantly in gestational age, birth weight, race, sex, PCO2, Apgar scores, or occurrence of severe intraventricular hemorrhage. There was no difference in mean CBF velocity (P = .934) in infants with hypotension (MABP: 23 [20-24.9] mm Hg) compared with infants with normal blood pressure (MABP: 32.6 [27.5-35.7] mm Hg).
  
  
  CONCLUSIONS
  Despite having hypotension, ELBW infants (before treatment) had similar CBF velocity compared with control subjects with normal blood pressure. On the basis of these results, hypotension may not indicate decreased CBF.
authors.affiliation: Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
authors.forename: Marla H
authors.initials: MH
authors.lastname: Lightburn
authors.forename: C Heath
authors.initials: CH
authors.lastname: Gauss
authors.forename: D Keith
authors.initials: DK
authors.lastname: Williams
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Kaiser