title: Hippophae rhamnoides L. and dexpanthenol-bepanthene on blood flow after experimental skin burns in rats using 133Xe clearance technique.
abstract: The aim of the present experimental study was to determine and compare the effect of Hippophae rhamnoides L. extract (HRe-1) and of dexpanthenol on the blood flow of a wound region, in rats using xenon-133 ((133)Xe) clearance technique.
  
  
  METHODS
  Burn wounds were made on both thighs of rats and, HRe-1 and dexpanthenol were applied topically on the wound region only in the right thigh for a period of 8 days. The effect of HRe-1 and of dexpanthenol on blood flow of the wound region was assessed before and after their topical application by using the (133)Xe clearance technique.
  
  
  RESULTS
  HRe-1 increased significantly blood flow of the wound region (P<0.05). Dexpanthenol showed a smaller increase in blood flow. In conclusion, our results in rats suggest that HRe-1 increases blood flow of the wound area and can be used for the treatment of skin wound healing, preferably than dexpanthenol.
authors.affiliation: Department of Nuclear Medicine, Ataturk University, Medical School, 25240 Erzurum, Turkey. bedriseven@yahoo.com
authors.forename: Bedri
authors.initials: B
authors.lastname: Seven
authors.forename: Erhan
authors.initials: E
authors.lastname: Varoglu
authors.forename: Omer
authors.initials: O
authors.lastname: Aktas
authors.forename: Ali
authors.initials: A
authors.lastname: Sahin
authors.forename: Kenan
authors.initials: K
authors.lastname: Gumustekin
authors.forename: Senol
authors.initials: S
authors.lastname: Dane
authors.forename: Halis
authors.initials: H
authors.lastname: Suleyman