Copper-catalyzed domino rearrangement/dehydrogenation oxidation/carbene oxidation for one-pot regiospecific synthesis of highly functionalized polysubstituted furans.
A novel and efficient method for the regiospecific synthesis of polysubstituted furan aldehydes/ketones has been developed via a copper(I)-catalyzed rearrangement/dehydrogenation oxidation/carbene oxidation sequence of 1,5-enynes in situ formed from alkynols and diethyl but-2-ynedioate under atmospheric pressure. The domino reaction proceeds smoothly under mild conditions with commercially available catalysts and affords highly functionalized furans in moderate to good yields.
Cao
Hua
H
School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, PR China.
Jiang
Huanfeng
H
Yao
Wenjuan
W
Liu
Xiaohang
X