Complete chiral resolution using additive-induced crystal size bifurcation during grinding.
Grinding them down: By using a tailor-made additive, even in the absence of racemization in solution, abrasive grinding can yield an enantiopure solid state. This novel chiral resolution technique is based on an asymmetric bifurcation in the crystal size distribution as a result of stereoselective hampered crystal growth. R = o-tolyl.
Noorduin
Wim L
WL
IMM Solid State Chemistry, Radboud University Nijmegen, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
van der Asdonk
Pim
P
Meekes
Hugo
H
van Enckevort
Willem J P
WJ
Kaptein
Bernard
B
Leeman
Michel
M
Kellogg
Richard M
RM
Vlieg
Elias
E