Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs.
The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 microg/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T(4) and T(3) in exposed lambs without any effect in pregnant sheep. Our finding indicates that prenatal low-dose PBDE exposure results in PBDE storage in fat of offspring and can affect thyroid metabolism in the developing fetus.
Abdelouahab
Nadia
N
Département d'Obstétrique et de Gynécologie, Faculté de Médecine, Université de Sherbrooke, Sherbrooke, Qué., Canada.
Suvorov
Alexander
A
Pasquier
Jean-Charles
JC
Langlois
Marie-France
MF
Praud
Jean-Paul
JP
Takser
Larissa
L