Genetics of cardiac repolarization.
Prolongation of the electrocardiographic QT interval, a measure of cardiac repolarization, is associated with arrhythmogenic disorders and is a risk factor for sudden cardiac death. Two genome-wide association studies (GWAS) of variation in the QT interval in population-based cohorts now report association with variants in a subset of ion channel genes and other new associations.
Shah
Svati H
SH
Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC, USA. svati.shah@duke.edu
Pitt
Geoffrey S
GS