title: Pregnancy and drugs for cardiovascular diseases.
abstract: OBJECTIVE
  The course of pregnancy is associated with a number of changes in the female body. Literature data indicate that 1-3% of pregnant women develop some cardiac disorder. The aim of the study was to assess the prevalence of using cardiovascular agents in pregnancy, the rate of congenital malformations in neonates at in utero exposure to these agents, and the possible association of congenital malformations with the use of these drugs during pregnancy.
  
  
  RESULTS
  One arm of the study (one-month study) was performed at four maternity hospitals in Zagreb, Croatia. The other arm of the study (one-year study) was performed at the University Department of Gynaecology and Obstetrics, Genetic Counselling Unit, and Department of Pathology and Histology in Novi Sad, Serbia. Only pregnant women using drugs for cardiovascular disorders during pregnancy were included in the study. Final analysis included data on 134 (32 from Zagreb and 102 from Novi Sad) pregnant women. Following delivery or abortion, the newborns and foetuses were thoroughly examined and followed-up for the occurrence of minor or major malformations. Malformations were found in 8 (6.0%) foetuses and newborns.
  
  
  CONCLUSIONS
  For most cardiac disorders, the risk posed by the disease itself for both the mother and the foetus generally exceeds the postulated risk of medications used to treat the disease. If a pregnant woman requires such therapy, a respective agent with the best safety profile should definitely be prescribed.
authors.affiliation: Department of Anatomy, School of Medicine, University of Novi Sad, Novi Sad, Serbia. mirela.eric.@gmail.com
authors.forename: Mirela
authors.initials: M
authors.lastname: Erić
authors.forename: Marcel
authors.initials: M
authors.lastname: Leppée
authors.forename: Josip
authors.initials: J
authors.lastname: Culig
authors.forename: Dragan
authors.initials: D
authors.lastname: Krivokuća