Using the Stroop task to investigate the neural correlates of symptom change in schizophrenia.
This study examined brain activation during a cognitive inhibition task in patients with schizophrenia following changes in their positive symptoms. A Stroop task was used during functional magnetic resonance imaging in 11 patients with schizophrenia (patient group) and 9 healthy volunteers (control group). At baseline, the patient group showed significantly attenuated activation within the anterior cingulate gyrus, left pre-/postcentral gyrus and inferior frontal junction. At follow-up, there was a significant increase in activation in the left inferior frontal junction associated with a decrease in positive symptoms, suggesting this region plays a role in the development of these symptoms.
Krabbendam
Lydia
L
Department of Psychiatry and Neuropsychology, Maastricht University, PO BOX 616 (location VIJV), 6200 MD Maastricht, The Netherlands. l.krabbendam@sp.unimaas.nl
O'Daly
Owen
O
Morley
Lucy A
LA
van Os
Jim
J
Murray
Robin M
RM
Shergill
Sukhwinder S
SS