title: Lack of association between hemorheological alterations and upper-extremity deep vein thrombosis.
abstract: BACKGROUND
  There is an association between rheological alterations and lower extremity deep vein thrombosis, although no research has been carried out regarding the possible influence of rheological alterations in the development of venous thrombosis in the upper limbs.
  
  
  METHODS
  We have determined in 54 patients (23 male, 31 female; aged 35+/-11 years) with primary upper extremity deep vein thrombosis (UEDVT), and in a well matched control group of 87 subjects (41 male, 46 female; aged 36+/-12 years) the rheological profile (blood viscosity, plasma viscosity, fibrinogen, erythrocyte aggregation, erythrocyte deformability) along with plasma lipids (total cholesterol and triglycerides) and body mass index (BMI). Thrombophilic defects (antithrombin, protein C, protein S deficiencies, factor V Leiden, prothrombin G20210A mutation and antiphospholipid antibodies) were also determined.
  
  
  RESULTS
  No statistical differences were observed in any of the rheological parameters analyzed (p>0.05), as well as in plasma lipids and BMI (p>0.05) when cases and controls were compared. In investigating the associated factors, we found that more than 60% of events could be explained through effort (28%), thrombophilic defects (19%) and oral contraceptives (26%). Obesity and hyperlipidaemia were not associated with primary UEDVT.
  
  
  CONCLUSIONS
  Hemorheological alterations do not seem to contribute from a pathogenic point of view to the development of thrombotic events in this infrequent venous location, which is in accordance both with the absence of cardiovascular risk factors and the high shear forces existing in the upper extremity.
authors.affiliation: Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain. vaya_amp@gva.es
authors.forename: Amparo
authors.initials: A
authors.lastname: Vaya
authors.forename: Marisa
authors.initials: M
authors.lastname: Martinez Triguero
authors.forename: Marco
authors.initials: M
authors.lastname: Romagnoli
authors.forename: María
authors.initials: M
authors.lastname: López
authors.forename: Alicia
authors.initials: A
authors.lastname: Ricart
authors.forename: Dolores
authors.initials: D
authors.lastname: Corella