title: A short carboxy-terminal domain of polycystin-1 reorganizes the microtubular network and the endoplasmic reticulum.
abstract: Mutations of PKD1 cause autosomal dominant polycystic kidney disease (ADPKD), a syndrome characterized by kidney cysts and progressive renal failure. Polycystin-1, the protein encoded by PKD1, is a large integral membrane protein with a short carboxy-terminal cytoplasmic domain that appears to initiate multiple cellular programs. We report now that this polycystin-1 domain contains a novel motif responsible for rearrangements of intermediate filaments, microtubules and the endoplasmic reticulum (ER). This motif reveals homology to CLIMP-63, a microtubule-binding protein that rearranges the ER. Our findings suggest that polycystin-1 influences the shape and localization of both the microtubular network and the ER.
authors.affiliation: Renal Division, University Hospital Freiburg, Freiburg, Germany.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Gao
authors.forename: Lorenz K
authors.initials: LK
authors.lastname: Sellin
authors.forename: Michael
authors.initials: M
authors.lastname: Pütz
authors.forename: Christian
authors.initials: C
authors.lastname: Nickel
authors.forename: Michael
authors.initials: M
authors.lastname: Imgrund
authors.forename: Peter
authors.initials: P
authors.lastname: Gerke
authors.forename: Roland
authors.initials: R
authors.lastname: Nitschke
authors.forename: Gerd
authors.initials: G
authors.lastname: Walz
authors.forename: Albrecht G
authors.initials: AG
authors.lastname: Kramer-Zucker