title: Restoration of chemosensitivity by bortezomib: implications for refractory myeloma.
abstract: BACKGROUND
  A 59-year-old woman presented to the emergency department with a left rib fracture and was diagnosed with IgA multiple myeloma. The patient underwent autologous bone-marrow transplantation, and 14 months later she developed obstructive jaundice.
  
  
  METHODS
  Serum protein electrophoresis, contrast CT of thorax and abdomen, endoscopic retrograde cholangiopancreatography with endoscopic biopsy and pleural biopsy.
  
  
  METHODS
  Extramedullary plasmacytomas at pancreatic head and pleura.
  
  
  RESULTS
  Salvage chemotherapy regimens including bortezomib plus steroid, alkylators plus steroid, bortezomib plus anthracycline and radiotherapy, and combined bortezomib, cyclophosphamide, melphalan and steroid therapy.
authors.affiliation: Department of Medicine, Queen Mary Hospital, Hong Kong. jcschim@hku.hk
authors.forename: Chor Sang
authors.initials: CS
authors.lastname: Chim
authors.forename: Yu Yan
authors.initials: YY
authors.lastname: Hwang
authors.forename: Clara
authors.initials: C
authors.lastname: Pang
authors.forename: Tony W
authors.initials: TW
authors.lastname: Shek