Molecular recognition of a thymine bulge by a high affinity, deazaguanine-based hydrogen-bonding ligand.
7-Deazaguanine (7-DeG) was developed as a hydrogen-bonding module capable of enhanced recognition of uracil (U) and thymine (T); a water-soluble derivative displayed high affinity and selectivity toward DNA and RNA duplexes containing single T- and U-bulges.
Ong
Hugo C
HC
Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Mathews Avenue, Urbana, IL 61801, USA.
Arambula
Jonathan F
JF
Rao Ramisetty
Sreenivasa
S
Baranger
Anne M
AM
Zimmerman
Steven C
SC