title: Poincaré analysis of an overnight arterial oxygen saturation signal applied to the diagnosis of sleep apnea hypopnea syndrome.
abstract: The analysis of oxygen desaturations is a basic variable in polysomnographic studies for the diagnosis of sleep apnea. Several algorithms operating in the time domain already exist for sleep apnea detection via pulse oximetry, but in a disadvantageous way--they achieve either a high sensitivity or a high specificity. The aim of this study was to assess whether an alternative analysis of arterial oxygen saturation (SaO2) signals from overnight pulse oximetry could yield essential information on the diagnosis of sleep apnea hypopnea syndrome (SAHS). SaO2 signals from 117 subjects were analyzed. The population was divided into a learning dataset (70 patients) and a test set (47 patients). The learning set was used for tuning thresholds among the applied Poincaré quantitative descriptors. Results showed that the presence of apnea events in SAHS patients caused an increase in the SD1 Poincaré parameter. This conclusion was assessed prospectively using the test dataset. 90.9% sensitivity and 84.0% specificity were obtained in the test group. We conclude that Poincaré analysis could be useful in the study of SAHS, contributing to reduce the demand for polysomnographic studies in SAHS screening.
authors.affiliation: Biomedical Engineering and Telemedicine Researching Group (IBT), University of Cádiz, and Pneumology Department of Hospital Universitario Puerta del Mar de Cádiz, Cádiz, Spain. daniel.morillo@uca.es
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Morillo
authors.forename: Juan L
authors.initials: JL
authors.lastname: Rojas
authors.forename: Luis F
authors.initials: LF
authors.lastname: Crespo
authors.forename: Antonio
authors.initials: A
authors.lastname: León
authors.forename: Nicole
authors.initials: N
authors.lastname: Gross