Introductory remarks.
Premenstrual syndrome (PMS) is a difficult disorder to study because there is no convincing evidence for a simple, basal, physiologic lesion associated with it. PMS is characterized by a cyclic recurrence of symptoms of varying severity and is temporally related to menstruation, with exacerbation of symptoms during the luteal phase. Some new models are being developed to aid in studying PMS.
Rubinow
David R
DR