Maternally derived antibodies against Bordetella pertussis antigens pertussis toxin and filamentous hemagglutinin in preterm and full term newborns.
We measured IgG-anti-pertussis toxin and -IgG-anti-filamentous hemagglutinin antibody values in 43 full term and 34 preterm infants and 79 mothers. Antibody values were generally low and mean values were higher in full term than preterm infants. Transfer ratios increased with gestational age of the newborns. Based on these findings, maternal and neonatal immunization strategies should be considered to protect young infants from pertussis.
Heininger
Ulrich
U
Division of Pediatric Infectious Diseases, University Children's Hospital, Basel, Switzerland. Ulrich.Heininger@ukbb.ch
Riffelmann
Marion
M
Leineweber
Birgit
B
Wirsing von Koenig
Carl Heinz
CH