A web application to perform linkage disequilibrium and linkage analyses on a computational grid.
BACKGROUND
Unravelling the genetic architecture of complex traits requires large amounts of data, sophisticated models and large computational resources. The lack of user-friendly software incorporating all these requisites is delaying progress in the analysis of complex traits.


METHODS
Linkage disequilibrium and linkage analysis (LDLA) is a high-resolution gene mapping approach based on sophisticated mixed linear models, applicable to any population structure. LDLA can use population history information in addition to pedigree and molecular markers to decompose traits into genetic components. Analyses are distributed in parallel over a large public grid of computers in the UK.


RESULTS
We have proven the performance of LDLA with analyses of simulated data. There are real gains in statistical power to detect quantitative trait loci when using historical information compared with traditional linkage analysis. Moreover, the use of a grid of computers significantly increases computational speed, hence allowing analyses that would have been prohibitive on a single computer.


BACKGROUND
The authors have implemented LDLA within the freely available GridQTL software (www.gridqtl.org.uk).
Hernández-Sánchez
Jules
J
Institute of Evolutionary Biology, University of Edinburgh, King's Buildings, Ashworth Laboratories, Edinburgh, UK. jules.hernandez@ed.ac.uk
Grunchec
Jean-Alain
JA
Knott
Sara
S