title: Catalytic reduction of O2 by cytochrome C using a synthetic model of cytochrome C oxidase.
abstract: Cytochrome c oxidase (CcO) catalyzes the four-electron reduction of oxygen to water, the one-electron reductant Cytochrome c (Cytc) being the source of electrons. Recently we reported a functional model of CcO that electrochemically catalyzes the four-electron reduction of O(2) to H(2)O (Collman et al. Science 2007, 315, 1565). The current paper shows that the same functional CcO model catalyzes the four-electron reduction of O(2) using the actual biological reductant Cytc in a homogeneous solution. Both single and steady-state turnover kinetics studies indicate that O(2) binding is rate-determining and that O-O bond cleavage and electron transfer from reduced Cytc to the oxidized model complex are relatively fast.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, California 94305, USA. jpc@stanford.edu
authors.forename: James P
authors.initials: JP
authors.lastname: Collman
authors.forename: Somdatta
authors.initials: S
authors.lastname: Ghosh
authors.forename: Abhishek
authors.initials: A
authors.lastname: Dey
authors.forename: Richard A
authors.initials: RA
authors.lastname: Decréau
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang