Impact of prior percutaneous coronary intervention on the outcome of coronary artery bypass surgery: a multicenter analysis.
OBJECTIVE
Do prior percutaneous coronary interventions adversely affect the outcome of subsequent coronary artery bypass grafting? We investigated this effect on a multicenter basis.


METHODS
Eight cardiac surgical centers provided outcome data of 37,140 consecutive patients who underwent isolated first-time coronary bypass grafting between January 2000 and December 2005. Twenty-two patient characteristics and outcome variables were retrieved. Three groups of patients were analysed for in-hospital mortality and in-hospital major adverse cardiac events: patients without a previous percutaneous coronary intervention, with 1 previous intervention, and with 2 or more previous percutaneous coronary interventions before bypass grafting. A total of 29,928 patients with complete information for prior percutaneous coronary intervention underwent final analysis. Unadjusted univariate and risk-adjusted multivariate logistic regression analysis as well as computed propensity score matching were performed, based on 14 major risk factors to correct for and minimize selection bias.


RESULTS
A total of 10.3% of patients had 1 previous percutaneous coronary intervention, and 3.7% of patients had 2 or more previous interventions. Risk-adjusted multivariate logistic regression analysis revealed a significant association of 2 or more previous percutaneous coronary interventions with in-hospital mortality (odds ratio [OR], 2.0; confidence interval [CI], 1.4-3.0; P = .0005) and major adverse cardiac events (OR, 1.5; CI, 1.2-1.9; P = .0013). After propensity score matching, conditional logistic regression analysis confirmed the results of adjusted analysis. A history of 2 or more previous percutaneous coronary interventions was significantly associated with in-hospital mortality (OR, 1.9; CI, 1.3-2.7; P = .0016) and major adverse cardiac events (OR, 1.5; CI, 1.2-1.9; P = .0019).


CONCLUSIONS
Multicenter analysis confirms that a history of multiple previous percutaneous coronary interventions increases in-hospital mortality and the incidence of major adverse cardiac events after subsequent coronary artery bypass grafting. Critical discussion of the treatment strategy in these patients is warranted.
Massoudy
Parwis
P
Department of Thoracic and Cardiovascular Surgery, West-German Heart Center Essen, Essen, Germany. parwis.massoudy@uk-essen.de
Thielmann
Matthias
M
Lehmann
Nils
N
Marr
Anja
A
Kleikamp
Georg
G
Maleszka
Ariane
A
Zittermann
Armin
A
Körfer
Reiner
R
Radu
Miriam
M
Krian
Arno
A
Litmathe
Jens
J
Gams
Emmeran
E
Sezer
Omer
O
Scheld
Hans
H
Schiller
Wolfgang
W
Welz
Armin
A
Dohmen
Guido
G
Autschbach
Rüdiger
R
Slottosch
Ingo
I
Wahlers
Thorsten
T
Neuhäuser
Markus
M
Jöckel
Karl-Heinz
KH
Jakob
Heinz
H