title: Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging.
abstract: The purpose of this study was to examine cerebral blood flow (CBF) as measured by arterial spin labeling (ASL) in tissue classified as white matter hyperintensities (WMH), normal appearing white matter, and grey matter. Seventeen healthy older adults received structural and ASL MRI. Cerebral blood flow was derived for three tissue types: WMH, normal appearing white matter, and grey matter. Cerebral blood flow was lower in WMH areas relative to normal appearing white matter, which in turn, was lower than grey matter. Regions with consistently lower CBF across individuals were more likely to appear as WMH. Results are consistent with an emerging literature linking diminished regional perfusion with the risk of developing WMH.
authors.affiliation: Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, United States. amb2139@columbia.edu
authors.forename: Adam M
authors.initials: AM
authors.lastname: Brickman
authors.forename: Amir
authors.initials: A
authors.lastname: Zahra
authors.forename: Jordan
authors.initials: J
authors.lastname: Muraskin
authors.forename: Jason
authors.initials: J
authors.lastname: Steffener
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Holland
authors.forename: Christian
authors.initials: C
authors.lastname: Habeck
authors.forename: Ajna
authors.initials: A
authors.lastname: Borogovac
authors.forename: Marco A
authors.initials: MA
authors.lastname: Ramos
authors.forename: Truman R
authors.initials: TR
authors.lastname: Brown
authors.forename: Iris
authors.initials: I
authors.lastname: Asllani
authors.forename: Yaakov
authors.initials: Y
authors.lastname: Stern