A wireless bio-MEMS sensor for C-reactive protein detection based on nanomechanics.
A quick wireless label-free detection of disease-related C-reactive proteins (CRPs) using a 200-microm-long microelectromechanical systems (MEMS) microcantilever housed in a 7 x 7 mm(2) reaction chamber with a safe reusable feature is reported. The assay time ranges from about 30 min to 3 h, depending on accuracy. The deflection of the microcantilever due to specific CRP-antiCRP binding is detected using a position-sensitive detector. The converted bio-signal is transmitted by a custom designed wireless amplitude-shift-keying (ASK) transceiver IC fabricated in a 0.18 microm CMOS process. CRP concentrations from 1 microg/mL to 500 microg/mL can be detected. A 0.2-Hz 1-V ac signal instead of traditional bases/acids is applied to the bio-MEMS sensor to unbind the CRP from the microcantilever for reusability.
Chen
Chun-Hao
CH
Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan 106, ROC.
Hwang
Rong-Zhang
RZ
Huang
Long-Sun
LS
Lin
Shi-Ming
SM
Chen
Hsiao-Chin
HC
Yang
Yu-Che
YC
Lin
Yu-Tso
YT
Yu
Shih-An
SA
Lin
Yo-Sheng
YS
Wang
Yiao-Hong
YH
Chou
Nai-Kuan
NK
Lu
Shey-Shi
SS