Recyclable organocatalysis: highly enantioselective Michael addition of 1,3-diaryl-1,3-propanedione to nitroolefins.
The first Michael addition of 1,3-diaryl-1,3-propanedione to nitroolefins was demonstrated using a simple organocatalyst, which afforded excellent yields (81-97%) and enantioselectivities (90 to >99% ee); the catalyst and excess reactant can be reused seven times through a simple filtration operation.
Tan
Bin
B
Division of Chemistry and Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
Zhang
Xuan
X
Chua
Pei Juan
PJ
Zhong
Guofu
G