Synthesis of a novel, optically active uridine analog containing a 1,4-dioxane sugar moiety. Synthesis of the corresponding dinucleotide.
A new optically active uridine nucleoside analogue in which a substituted 1,4-dioxane ring functioned as the sugar analogue was prepared from L-tartaric acid. The nucleoside analogue was further converted into the corresponding protected dinucleotide.
Yu
Qiang
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Department of Chemistry, Norwegian University of Science and Technology, NTNU, Trondheim, Norway.
Carlsen
Per
P