Reversible hypogonadism in Bardet-Biedl syndrome.
OBJECTIVE
To report a patient with Bardet-Biedl syndrome (BBS) with known hypogonadotrophic hypogonadism who developed spontaneous reversal of hypogonadism in adulthood.


METHODS
Case report and discussion.


METHODS
Endocrine unit of a tertiary hospital.


METHODS
A 30-year-old male patient with BBS.


METHODS
Clinical evaluation, fine-needle aspiration of the testes, hormonal, cytogenetic, and pathologic evaluation.


METHODS
Serum gonadotropins and testosterone levels and presence of spermatogenesis in testicular aspirate.


RESULTS
Serum testosterone and gonadotropin levels were within the normal adult male range. Testicular aspirates showed spermatogenic cells of all series, including numerous spermatozoa and a few intact seminiferous tubules. The overall picture appeared to be consistent with normal spermatogenesis.


CONCLUSIONS
This is the first case of reversal of hypogonadotrophic hypogonadism in a male patient with BBS. Clinicians should look for such reversal in other patients with hypogonadotrophic hypogonadism and give appropriate prognosis.
Desai
Ankush
A
Department of Endocrinology and Metabolism, All India Institute of Medical Sciences, New Delhi, India.
Jha
Onkar
O
Iyer
Venkateswaran
V
Dada
Rima
R
Kumar
Rakesh
R
Tandon
Nikhil
N