Association of estrogen receptor alpha gene polymorphism with the presence of coronary artery disease documented by coronary angiography.
OBJECTIVE
To examine the relationship between PvuII and XbaI polymorphisms, with the presence of angiographically determined CAD in an Iranian population.


METHODS
Patients having angiographic evidence of atherosclerosis (Gensini score > 6) in their epicardial coronary tree (CAD(+) case group) were compared with Patients with Gensini score < or = 6 (CAD(-) control group). The presence of PvuII and XbaI polymorphisms was analyzed using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP).


RESULTS
The PvuIIota genotype distributions were not statistically different in CAD groups, and subgroups stratified by gender. For the XbaI polymorphism, after controlling for age, male sex, cigarette smoking and hyperlipidemia, XbaI GG genotype was not also found to be an independent predictor for CAD occurrence (OR=1.65; 95% CI: 0.90-3.03; P=0.10).


CONCLUSIONS
We did not observe an association between ESR1 PvuII and XbaI gene polymorphisms with CAD in the risk of CAD in an Iranian population.
Boroumand
Mohammadali
M
Tehran Heart Center, Tehran University of Medical Sciences, North Karegar Avenue, Tehran, Iran. maboroumand@yahoo.com
Ghaedi
Mahboubeh
M
Mohammadtaghvaei
Narges
N
Pourgholi
Leila
L
Anvari
Maryam Sotoudeh
MS
Davoodi
Gholamreza
G
Amirzadegan
Alireza
A
Saadat
Soheil
S
Sheikhfathollahi
Mahmood
M
Goodarzynejad
Hamidreza
H