Discovery of the butenyl-spinosyn insecticides: novel macrolides from the new bacterial strain Saccharopolyspora pogona.
A new bacterium, Saccharopolyspora pogona (NRRL30141) was discovered which produced a series of very potent insecticidal compounds structurally related to the 'classical' (i.e., C-21-ethyl) spinosyns. A series of fermentations gave sufficient extract to allow the isolation and characterization of a total of 31 new metabolites. The majority of these compounds contained a but-1-enyl group at C-21 of the macrolide in place of the ethyl group in the 'classical' spinosyn series, corresponding to an additional acetate group incorporated during their biosynthesis. Additionally a variety of other new functionality was seen including hydroxylations, several novel forosamine sugar replacements, and a novel 14-membered macrolide ring analog.
Lewer
Paul
P
Dow AgroSciences, 9330 Zionsville Road, Indianapolis, IN 46033, USA.
Hahn
Donald R
DR
Karr
Laura L
LL
Duebelbeis
Dennis O
DO
Gilbert
Jeffrey R
JR
Crouse
Gary D
GD
Worden
Thomas
T
Sparks
Thomas C
TC
Edwards
Pat McKamey Rex
PM
Graupner
Paul R
PR