title: Variation in P2RX7 candidate gene (rs2230912) is not associated with bipolar I disorder and unipolar major depression in four European samples.
abstract: Two recent studies reported evidence for association between genetic variation of the positional candidate gene P2RX7 on chromosome 12q24 and bipolar I disorder (BPI) [Barden et al. (2006); Am J Med Genet Part B 141B:374-382; McQuillin et al. (2008); Mol Psychiatry 13:1-7] and one study found association with unipolar major depression (Mdd-UP) [Lucae et al. (2006); Hum Mol Genet 15:2438-2445]. In the present work, we aimed to replicate the SNP that showed the strongest association in the above-mentioned studies, namely rs2230912 (P2RX7-E13A) resulting in a change of the amino acid glutamine to arginine at position 460 (Gln460Arg), in four European bipolar I disorder samples from Germany, Poland, Romania, and Russia totaling 1,445 patients, in a German sample of recurrent Mdd-UP patients (N = 640), and a control sample of 2,006 subjects. We found no allelic or genotypic association between rs2230912 and BPI or Mdd-UP both in the national samples and in the combined European patient sample. Additional studies are needed to clarify the potential involvement of P2RX7 and of SNP rs2230912 in the etiology of major affective disorders.
authors.affiliation: Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Psychiatric Hospital, Bucharest, Romania. maria.serbanescu@googlemail.com
authors.forename: Maria
authors.initials: M
authors.lastname: Grigoroiu-Serbanescu
authors.forename: Stefan
authors.initials: S
authors.lastname: Herms
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Mühleisen
authors.forename: Alexander
authors.initials: A
authors.lastname: Georgi
authors.forename: Carmen C
authors.initials: CC
authors.lastname: Diaconu
authors.forename: Jana
authors.initials: J
authors.lastname: Strohmaier
authors.forename: Piotr
authors.initials: P
authors.lastname: Czerski
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
authors.forename: Anna
authors.initials: A
authors.lastname: Leszczynska-Rodziewicz
authors.forename: Rami Abou
authors.initials: RA
authors.lastname: Jamra
authors.forename: Gulia
authors.initials: G
authors.lastname: Babadjanova
authors.forename: A
authors.initials: A
authors.lastname: Tiganov
authors.forename: V
authors.initials: V
authors.lastname: Krasnov
authors.forename: Sofia
authors.initials: S
authors.lastname: Kapiletti
authors.forename: Ana Iulia
authors.initials: AI
authors.lastname: Neagu
authors.forename: Jennifer
authors.initials: J
authors.lastname: Vollmer
authors.forename: René
authors.initials: R
authors.lastname: Breuer
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
authors.forename: Peter
authors.initials: P
authors.lastname: Propping
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon