title: Interplay between virus-specific effector response and Foxp3 regulatory T cells in measles virus immunopathogenesis.
abstract: Measles is a highly contagious childhood disease associated with an immunological paradox: although a strong virus-specific immune response results in virus clearance and the establishment of a life-long immunity, measles infection is followed by an acute and profound immunosuppression leading to an increased susceptibility to secondary infections and high infant mortality. In certain cases, measles is followed by fatal neurological complications. To elucidate measles immunopathology, we have analyzed the immune response to measles virus in mice transgenic for the measles virus receptor, human CD150. These animals are highly susceptible to intranasal infection with wild-type measles strains. Similarly to what has been observed in children with measles, infection of suckling transgenic mice leads to a robust activation of both T and B lymphocytes, generation of virus-specific cytotoxic T cells and antibody responses. Interestingly, Foxp3(+)CD25(+)CD4(+) regulatory T cells are highly enriched following infection, both in the periphery and in the brain, where the virus intensively replicates. Although specific anti-viral responses develop in spite of increased frequency of regulatory T cells, the capability of T lymphocytes to respond to virus-unrelated antigens was strongly suppressed. Infected adult CD150 transgenic mice crossed in an interferon receptor type I-deficient background develop generalized immunosuppression with an increased frequency of CD4(+)CD25(+)Foxp3(+) T cells and strong reduction of the hypersensitivity response. These results show that measles virus affects regulatory T-cell homeostasis and suggest that an interplay between virus-specific effector responses and regulatory T cells plays an important role in measles immunopathogenesis. A better understanding of the balance between measles-induced effector and regulatory T cells, both in the periphery and in the brain, may be of critical importance in the design of novel approaches for the prevention and treatment of measles pathology.
authors.affiliation: Immunobiology of Viral Infections, Inserm, U758, Lyon, France.
authors.forename: Caroline I
authors.initials: CI
authors.lastname: Sellin
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Jégou
authors.forename: Joëlle
authors.initials: J
authors.lastname: Renneson
authors.forename: Johan
authors.initials: J
authors.lastname: Druelle
authors.forename: T Fabian
authors.initials: TF
authors.lastname: Wild
authors.forename: Julien C
authors.initials: JC
authors.lastname: Marie
authors.forename: Branka
authors.initials: B
authors.lastname: Horvat