title: The highly enantioselective phase-transfer catalytic mono-alkylation of malonamic esters.
abstract: The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-alpha-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality.
authors.affiliation: Research Institute of Pharmaceutical Sciences and College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Kim
authors.forename: Sea-Hoon
authors.initials: SH
authors.lastname: Choi
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jihye
authors.initials: J
authors.lastname: Lee
authors.forename: Keepyung
authors.initials: K
authors.lastname: Nahm
authors.forename: Byeong-Seon
authors.initials: BS
authors.lastname: Jeong
authors.forename: Hyeung-Geun
authors.initials: HG
authors.lastname: Park
authors.forename: Sang-Sup
authors.initials: SS
authors.lastname: Jew