title: Sonodynamic effects of lomefloxacin derivatives conjugated with methoxy polyethylene glycol on sarcoma 180 cells.
abstract: BACKGROUND
  Sonodynamic therapy (SDT) is a promising methodology for cancer treatment. Lomefloxacin hydrochloride (LFLX) has been reported to have sonodymamic antitumor effects.
  
  
  METHODS
  We synthesized LFLX derivatives conjugated with methoxy polyethylene glycol (PEGylated LFLXs) and investigated their ultrasonically induced antitumor effects.
  
  
  RESULTS
  After ultrasound exposure at 2.0 MHz for 30 s, the survival rates of Sarcoma 180 cells in the presence of lower molecular weight PEGylated LFLXs (200 microM) were significantly lower than those of the control and the LFLX at 1.5 and 2.0 W/cm2. This enhancement was significantly inhibited by the addition of L-histidine, but not by D-mannitol or superoxide dismutase. There was no apparent cell damage in the presence of high molecular weight PEGylated LFLX even at 3.0 W/cm2.
  
  
  CONCLUSIONS
  These findings indicate that the sonodynamic antitumor effects of lower molecular weight PEGylated LFLXs are better than those of LFLX.
authors.affiliation: Pharmaceutical Science, Akita University Hospital, Akita 010-8543, Japan.
authors.forename: Chiyo
authors.initials: C
authors.lastname: Komori
authors.forename: Kyoji
authors.initials: K
authors.lastname: Okada
authors.forename: Koichi
authors.initials: K
authors.lastname: Kawamura
authors.forename: Norio
authors.initials: N
authors.lastname: Suzuki
authors.forename: Shuichi
authors.initials: S
authors.lastname: Chida
authors.forename: Toshio
authors.initials: T
authors.lastname: Suzuki