title: Effect of intravenous administration of paracetamol on morphine consumption in cancer pain control.
abstract: OBJECTIVE
  The present study aimed to examine the effectiveness of intravenous administration of paracetamol added to morphine in the control of cancer pain and its possible contribution as reduction of opioid consumption and opioid-related side effects.
  
  
  METHODS
  A total of 43 patients with chronic cancer pain without neuropathic origin aged between 18 and 76 years and receiving step 2 treatment according to the World Health Organization analgesic ladder were included. Patients were randomized to receive intravenous administration of saline (control) or 1 g of paracetamol on top of morphine. Visual analog scale (VAS), patient rating index (PRI), Eastern Cooperative Oncology Group (ECOG) status, patient satisfaction, and safety were evaluated.
  
  
  RESULTS
  Both treatments resulted in improved VAS and PRI scores compared to baseline. However, groups did not differ in terms of VAS and PRI scores, morphine consumption, side-effect frequencies, laboratory values, ECOG status, and patient satisfaction.
  
  
  CONCLUSIONS
  Although safe and there are signals for a true analgesic efficacy, our results failed to confirm any benefits of add-on treatment with intravenous administration of paracetamol. However, the study was underpowered, and future studies in this important area need to be wary of background noise and the risk of a type II error.
authors.affiliation: Pain Clinic, Department of Anaesthesiology and Reanimation, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey.
authors.forename: Buket
authors.initials: B
authors.lastname: Tasmacioglu
authors.forename: Isik
authors.initials: I
authors.lastname: Aydinli
authors.forename: Kader
authors.initials: K
authors.lastname: Keskinbora
authors.forename: Ali Ferit
authors.initials: AF
authors.lastname: Pekel
authors.forename: Tamer
authors.initials: T
authors.lastname: Salihoglu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sonsuz