title: Mechanism of anti-angiogenic activities of chitooligosaccharides may be through inhibiting heparanase activity.
abstract: Metastatic disease is the primary cause of death for most cancer patients. Angiogenesis is the formation of a new capillary network from pre-existing vessels and required for tumor vasculature. Heparanase, a beta-endoglucuronidase, assistants tumor invasion, metastasis and angiogenesis. Chitooligosaccharides (COS) is obtained by hydrolysis of chitosan. COS has been proved to be anti-angiogenesis activity. The mechanism of COS inhibits angiogenesis is not very clear, COS is hypothesized by author to be an inhibitor of heparanase.
authors.affiliation: Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Animal Sciences Institute, Zhejiang University, Qiutao North Road 164, Zhejiang, Hangzhou 310029, China.
authors.forename: Haizhi
authors.initials: H
authors.lastname: Quan
authors.forename: Fei
authors.initials: F
authors.lastname: Zhu
authors.forename: Xinyan
authors.initials: X
authors.lastname: Han
authors.forename: Zirong
authors.initials: Z
authors.lastname: Xu
authors.forename: Yilong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Zhiguo
authors.initials: Z
authors.lastname: Miao