title: 3-(Arylamino)-3-phenylpropan-2-olamines as a new series of dual norepinephrine and serotonin reuptake inhibitors.
abstract: A series of 3-(arylamino)-3-phenylpropan-2-olamines was prepared and screened for their ability to inhibit monoamine reuptake. A number of analogues displayed significant dual norepinephrine and serotonin reuptake inhibition. Compounds in this class exhibited minimal affinity for the dopamine transporter.
authors.affiliation: Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA.
authors.forename: An T
authors.initials: AT
authors.lastname: Vu
authors.forename: Stephen T
authors.initials: ST
authors.lastname: Cohn
authors.forename: Eugene A
authors.initials: EA
authors.lastname: Terefenko
authors.forename: William J
authors.initials: WJ
authors.lastname: Moore
authors.forename: Puwen
authors.initials: P
authors.lastname: Zhang
authors.forename: Paige E
authors.initials: PE
authors.lastname: Mahaney
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Trybulski
authors.forename: Igor
authors.initials: I
authors.lastname: Goljer
authors.forename: Rebecca
authors.initials: R
authors.lastname: Dooley
authors.forename: Jenifer A
authors.initials: JA
authors.lastname: Bray
authors.forename: Grace H
authors.initials: GH
authors.lastname: Johnston
authors.forename: Jennifer
authors.initials: J
authors.lastname: Leiter
authors.forename: Darlene C
authors.initials: DC
authors.lastname: Deecher