Mechanism of anti-angiogenic activities of chitooligosaccharides may be through inhibiting heparanase activity.
Metastatic disease is the primary cause of death for most cancer patients. Angiogenesis is the formation of a new capillary network from pre-existing vessels and required for tumor vasculature. Heparanase, a beta-endoglucuronidase, assistants tumor invasion, metastasis and angiogenesis. Chitooligosaccharides (COS) is obtained by hydrolysis of chitosan. COS has been proved to be anti-angiogenesis activity. The mechanism of COS inhibits angiogenesis is not very clear, COS is hypothesized by author to be an inhibitor of heparanase.
Quan
Haizhi
H
Key Laboratory for Molecular Animal Nutrition of Ministry of Education, Feed Animal Sciences Institute, Zhejiang University, Qiutao North Road 164, Zhejiang, Hangzhou 310029, China.
Zhu
Fei
F
Han
Xinyan
X
Xu
Zirong
Z
Zhao
Yilong
Y
Miao
Zhiguo
Z