title: Association of a 5-HT1Dbeta receptor gene polymorphism with obsessive-compulsive disorder in Korean male subjects.
abstract: The 5-HT1Dbeta receptor gene appears to be particularly interesting in the pathophysiology of obsessive-compulsive disorder (OCD). The 5-HT1Dbeta receptor is a terminal autoreceptor involved in the regulation of serotonin synthesis and release. We performed an association study of the G861C single nucleotide polymorphism (SNP) of the 5-HT1Dbeta receptor in 167 male Korean OCD subjects and in 107 controls. Individuals with the G allele had an increased chance of having OCD (OR 1.49, 95% CI 1.05-2.10). Our findings suggest an association between the G861C SNP of the 5-HT1Dbeta receptor and males with OCD. In the future, other tag SNPs that cover the entire 5-HT1Dbeta gene region as well as additional SNPs that are supposed to have meaningful functions should be investigated in both male and female OCD subjects.
authors.affiliation: Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University, College of Medicine, Seoul, Republic of Korea.
authors.forename: Se Joo
authors.initials: SJ
authors.lastname: Kim
authors.forename: Kee
authors.initials: K
authors.lastname: Namkoong
authors.forename: Jee In
authors.initials: JI
authors.lastname: Kang
authors.forename: Chan-Hyung
authors.initials: CH
authors.lastname: Kim