title: [Change of antimalarial first-line treatment in Burkina Faso in 2005].
abstract: Burkina Faso has recently changed the antimalarial drug policy to artesunate/amodiaquine or artemether/lumefantrine as the first-line antimalarial drug and sulfadoxine/pyrimethamine for the intermittent preventive treatment in pregnant woman. Before the implementation of this new strategy we conducted an in vivo efficacy study with chloroquine or sulfadoxine/pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in urban area of Burkina from September to December 2003. Chloroquine (25 mg/kg over 3 days) or sulfadoxine/pyrimethamine (25 mg/kg + 0.025 mg/kg single dose) was administered respectively to 137 and 125 children aged from 6 to 59 months old in a randomized, opened study. Follow up extended over 28 days using modified WHO protocol. After adjusting the results by PCR, treatment failures rates were 63.4% (83/131) and 13.8% (17/123) respectively for chloroquine and sulfadoxine/pyrimethamine. These results with other observations have justified the change of malaria therapy policy in Burkina Faso in 2005.
authors.affiliation: Centre national de recherche et de formation sur le paludisme, BP 2208 Ouagadougou 01, Burkina Faso.
authors.forename: A
authors.initials: A
authors.lastname: Gansané
authors.forename: I
authors.initials: I
authors.lastname: Nébié
authors.forename: I
authors.initials: I
authors.lastname: Soulama
authors.forename: A
authors.initials: A
authors.lastname: Tiono
authors.forename: A
authors.initials: A
authors.lastname: Diarra
authors.forename: A T
authors.initials: AT
authors.lastname: Konaté
authors.forename: A
authors.initials: A
authors.lastname: Ouédraogo
authors.forename: B S
authors.initials: BS
authors.lastname: Sirima