title: Bacteriostatic and bactericidal activities of tigecycline against Coxiella burnetii and comparison with those of six other antibiotics.
abstract: The present article is a study of the in vitro susceptibility of eight Greek Coxiella burnetii isolates, derived from patients with acute Q fever, and two reference strains of Coxiella burnetii to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 microg/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 microg/ml; linezolid and clarithromycin ranged from 2 to 4 microg/ml; and ciprofloxacin ranged from 4 to 8 microg/ml. Tigecycline was effective in inhibiting the infection of Vero cells by C. burnetii. No bactericidal activity was observed against C. burnetii at 4 microg/ml.
authors.affiliation: Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, P.O. Box 1393, Heraklion, Crete, Greece. ispyridaki@med.uoc.gr
authors.forename: Ioanna
authors.initials: I
authors.lastname: Spyridaki
authors.forename: Anna
authors.initials: A
authors.lastname: Psaroulaki
authors.forename: Iosif
authors.initials: I
authors.lastname: Vranakis
authors.forename: Yannis
authors.initials: Y
authors.lastname: Tselentis
authors.forename: Achilleas
authors.initials: A
authors.lastname: Gikas