title: Hemocompatibility evaluation with experimental and computational fluid dynamic analyses for a monopivot circulatory assist pump.
abstract: The hemocompatibility of a newly developed monopivot circulatory assist pump was evaluated by the computational fluid dynamic (CFD) analyses with the particle tracking velocimetry measurement. Results were compared with those of the hemolysis test and in vitro antithrombogenic test to prevent hemolysis and thrombus formation inside the pump. The results of the CFD analysis and the particle tracking velocimetry had a good agreement with each other. The flow distributions by the CFD analysis indicated that the radial jet out of the impeller was adequately weak so that the wall shear stress was lower than 300 Pa on the volute casing wall. It corresponded with the hemolysis tests results, indicating that the hemolysis level was lower than that of the commercially available pump. However, the flow distributions also indicated that the pivot that was easy to stagnate was washed out, not only by the secondary flow through the back gap of the impeller, but also by the vortices generated by the secondary vanes. It corresponded with the in vitro antithrombogenic test results, indicating that thrombus formation could be removed only by redesigning the geometry of the secondary vanes.
authors.affiliation: Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology Tsukuba, Ibaraki, Japan. masahiro.nishida@aist.go.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Nishida
authors.forename: Osamu
authors.initials: O
authors.lastname: Maruyama
authors.forename: Ryo
authors.initials: R
authors.lastname: Kosaka
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamane
authors.forename: Hisato
authors.initials: H
authors.lastname: Kogure
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawamura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Kuwana
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Sankai
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Tsutsui