Catalytic enantioselective construction of all-carbon quaternary stereocenters by an organocatalytic Diels-Alder reaction of alpha-substituted alpha,beta-unsaturated aldehydes.
A binaphthyl-based primary amine (R)- was designed for the Diels-Alder reaction of alpha-substituted alpha,beta-unsaturated aldehydes; in the presence of the TfOH salt of (R)-, the Diels-Alder reaction of alpha-substituted alpha,beta-unsaturated aldehydes with cyclopentadiene proceeded to afford the corresponding cycloadducts having one all-carbon quaternary stereocenter in good yield with good to high stereoselectivity.
Kano
Taichi
T
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
Tanaka
Youhei
Y
Osawa
Kenta
K
Yurino
Taiga
T
Maruoka
Keiji
K