Myocardial insulin-like growth factor-1 and insulin-like growth factor binding protein-3 gene expression in failing hearts harvested from patients undergoing cardiac transplantation.
Insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding proteins (IGFBPs) might play a pathogenic role in heart failure. We showed significantly increased myocardial IGFBP-3 expression (investigated by real-time polymerase chain reaction) and apoptosis (detected by flow cytometry) in 23 failing hearts from patients undergoing cardiac transplantation for end-stage dilated or ischemic cardiomyopathy, when compared with 10 controls. Higher IGF-1 mRNA levels were shown only in end-stage dilated cardiomyopathy.
Pucci
Angela
A
Department of Pathology, Regina Margherita Hospital, Torino, Italy. angelapucci@libero.it
Zanini
Cristina
C
Granata
Riccarda
R
Ghignone
Roberta
R
Iavarone
Alberto
A
Broglio
Fabio
F
Sorrentino
Paolo
P
Bergamasco
Laura
L
Rinaldi
Mauro
M
Ghigo
Ezio
E