title: Bacterial complications during pandemic influenza infection.
abstract: Evaluation of: Morens DM, Taubenberger JK, Fauci AS: Predominant role of bacterial pneumonia as a cause of death in pandemic influenza: implications for pandemic influenza preparedness. J. Infect. Dis. 198(7), 962-970 (2008). Secondary bacterial pneumonia is a common occurrence following lung influenza virus infection and leads to a significantly worse prognosis. This recent re-analysis of postmortem specimens and a vast number of reports from past influenza pandemics shows an extremely high frequency of lung colonization by bacterial species that are commonly found in the nasopharynx. This polymicrobial condition occurred in the preantibiotic era 1918-1919 influenza pandemic, but there is also evidence of bacterial co-infections in those outbreaks that occurred after antibiotic introduction. As such, antibiotic treatment should be included in any pandemic preparedness strategy. However, the choice of which antibiotic to use is important since some may even heighten morbidity and mortality.
authors.affiliation: National Heart & Lung Institute, Leukocyte Biology Section, Imperial College London, Exhibition Road, London, UK. t.hussell@imperial.ac.uk
authors.forename: Tracy
authors.initials: T
authors.lastname: Hussell
authors.forename: Erika
authors.initials: E
authors.lastname: Wissinger
authors.forename: John
authors.initials: J
authors.lastname: Goulding