title: Dendritic cell therapy in composite tissue allotransplantation.
abstract: Dendritic cells (DCs) are bone marrow-derived, professional antigen-presenting cells, with inherent tolerogenic function. The ability of immature or maturation-resistant DCs to regulate alloantigen-specific T-cell responses and to promote tolerance induction has been well demonstrated in organ and bone marrow transplantation. Recent data suggest that DCs can also promote long-term survival of composite tissue allografts in the absence of continued immunosuppressive drug therapy.
authors.affiliation: Departments of Surgery and Immunology, Starzl Transplantation Institute and Division of Plastic Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. thomsonaw@upmc.edu
authors.forename: A W
authors.initials: AW
authors.lastname: Thomson
authors.forename: J M
authors.initials: JM
authors.lastname: Sacks
authors.forename: Y-R
authors.initials: YR
authors.lastname: Kuo
authors.forename: R
authors.initials: R
authors.lastname: Ikeguchi
authors.forename: E K
authors.initials: EK
authors.lastname: Horibe
authors.forename: J
authors.initials: J
authors.lastname: Unadkat
authors.forename: M G
authors.initials: MG
authors.lastname: Solari
authors.forename: M
authors.initials: M
authors.lastname: Feili-Hariri
authors.forename: W P A
authors.initials: WP
authors.lastname: Lee