title: [Afobazole decreases motor side effects induced by haloperidol].
abstract: Experiments on mice showed that a single intraperitoneal administration of anxiolytic afobazole (10 mg/kg) increases the effect of haloperidol in the apomorphine-induced climbing test and does not influence the catalepsy caused by the neuroleptic agent. The daily dose of afobazole 10 mg/kg during a five-day preliminary test reduced the extrapyramidal effects of haloperidole on rats and mice without significant change of the apomorphine-induced climbing test results. The ability of afobazole to reduce extrapyramidal disturbances caused by haloperidol can be related to the agonist effect of afobazole with respect to sigma 1 receptors.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: T A
authors.initials: TA
authors.lastname: Garibova
authors.forename: A L
authors.initials: AL
authors.lastname: Kuznetsova
authors.forename: M V
authors.initials: MV
authors.lastname: Voronin
authors.forename: M A
authors.initials: MA
authors.lastname: Iarkova
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina