title: Discovery of the butenyl-spinosyn insecticides: novel macrolides from the new bacterial strain Saccharopolyspora pogona.
abstract: A new bacterium, Saccharopolyspora pogona (NRRL30141) was discovered which produced a series of very potent insecticidal compounds structurally related to the 'classical' (i.e., C-21-ethyl) spinosyns. A series of fermentations gave sufficient extract to allow the isolation and characterization of a total of 31 new metabolites. The majority of these compounds contained a but-1-enyl group at C-21 of the macrolide in place of the ethyl group in the 'classical' spinosyn series, corresponding to an additional acetate group incorporated during their biosynthesis. Additionally a variety of other new functionality was seen including hydroxylations, several novel forosamine sugar replacements, and a novel 14-membered macrolide ring analog.
authors.affiliation: Dow AgroSciences, 9330 Zionsville Road, Indianapolis, IN 46033, USA.
authors.forename: Paul
authors.initials: P
authors.lastname: Lewer
authors.forename: Donald R
authors.initials: DR
authors.lastname: Hahn
authors.forename: Laura L
authors.initials: LL
authors.lastname: Karr
authors.forename: Dennis O
authors.initials: DO
authors.lastname: Duebelbeis
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Gilbert
authors.forename: Gary D
authors.initials: GD
authors.lastname: Crouse
authors.forename: Thomas
authors.initials: T
authors.lastname: Worden
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Sparks
authors.forename: Pat McKamey Rex
authors.initials: PM
authors.lastname: Edwards
authors.forename: Paul R
authors.initials: PR
authors.lastname: Graupner