title: Continuous decrease in serum brain-derived neurotrophic factor (BDNF) levels in a neuropsychiatric syndrome of systemic lupus erythematosus patient with organic brain changes.
abstract: In the present study, the authors reported on a case in neuropsychiatric syndromes of systemic lupus erythematosus (NPSLE) with irreversible organic brain changes. The authors also longitudinally investigated serum brain-derived neurotrophic factor (BDNF) levels in the patient. We found that serum BDNF levels in the NPSLE patient with irreversible organic brain change were consistently low, independent of the severity of psychiatric symptoms. Thus, the longitudinal measurement of serum BDNF levels might be useful in predicting the prognosis of NPSLE.
authors.affiliation: Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Ikenouchi-Sugita
authors.forename: Reiji
authors.initials: R
authors.lastname: Yoshimura
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Ueda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kodama
authors.forename: Wakako
authors.initials: W
authors.lastname: Umene-Nakano
authors.forename: Jun
authors.initials: J
authors.lastname: Nakamura