Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.
Cytoplasmic double-stranded DNA triggers cell death and secretion of the pro-inflammatory cytokine IL-1beta in macrophages. Recent reports now describe the mechanism underlying this observation. Upon sensing of DNA, the HIN-200 family member AIM2 triggers the assembly of the inflammasome, culminating in caspase-1 activation, IL-1beta maturation and pyroptotic cell death.
Schroder
Kate
K
Department of Biochemistry, University of Lausanne, Epalinges, Switzerland.
Muruve
Daniel A
DA
Tschopp
Jürg
J