title: Homology modelling of pyrophosphosrylase, enzyme involved in chitin pathway of Moniliophthora perniciosa.
abstract: Moniliophthora perniciosa (Sthael) (Singer) Phillips-Mora is the causal agent of witches' broom disease, which can infect Theobroma cacao decreasing the production of cocoa about 60%. M. perniciosa has a set of potential enzymes that can be useful targets for design of new inhibitors. After the release of the aminoacid sequence of pyrophosphorylase of M. perniciosa, a comparative modelling approach was carried out to obtain the 3D structure of this target. This model can be useful to develop new inhibitors against witches' broom disease.
authors.affiliation: PPGBiotec - UEFS/FIOCRUZ - BA, Universidade Estadual de Feira de Santana, Av. Transnordestina s/n, Novo Horizonte, Feira de Santana, BA, 44.036-900, Brazil. mc2500@gmail.com
authors.forename: Manoelito C
authors.initials: MC
authors.lastname: dos Santos
authors.forename: Alex G
authors.initials: AG
authors.lastname: Taranto
authors.forename: Sandra A
authors.initials: SA
authors.lastname: de Assis
authors.forename: Aristoteles
authors.initials: A
authors.lastname: Goes-Neto