title: Abnormal blood flow in the sublingual microcirculation at high altitude.
abstract: We report the first direct observations of deranged microcirculatory blood flow at high altitude, using sidestream dark-field imaging. Images of the sublingual microcirculation were obtained from a group of 12 volunteers during a climbing expedition to Cho Oyu (8,201 m) in the Himalayas. Microcirculatory flow index (MFI) was calculated from the moving images of microcirculatory red blood cell flow, and comparison was made between the baseline and high altitude measurements. Peripheral oxygen saturation (SpO(2)) and Lake Louise scores (LLS) were recorded along with MFI. Our data demonstrate that there was a significant reduction in MFI from baseline to 4,900 m in small (less than 25 microm) and medium (26-50 microm) sized blood vessels (P = 0.025 and P = 0.046, respectively). There was no significant correlation between MFI and SpO(2) or MFI and LLS. Disruption of blood flow within microcirculatory may explain persistent abnormal oxygen flux to tissues following the normalisation of systemic oxygen delivery that accompanies acclimatisation to high altitude.
authors.affiliation: Centre for Altitude, Space and Extreme Environment Medicine (CASE Medicine), UCL Institute of Human Health and Performance, First Floor, Charterhouse Building, Archway Campus, Highgate Hill, London, N19 5LW, UK. dan.s.martin@gmail.com
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Martin
authors.forename: Can
authors.initials: C
authors.lastname: Ince
authors.forename: Peter
authors.initials: P
authors.lastname: Goedhart
authors.forename: Denny Z H
authors.initials: DZ
authors.lastname: Levett
authors.forename: Mike P W
authors.initials: MP
authors.lastname: Grocott