title: Laparoscopic resection of sporadic synchronous gastric and jejunal gastrointestinal stromal tumors: report of a case.
abstract: Multicentricity of gastrointestinal stromal tumors (GISTs) has been described only in patients with neurofibromatosis type 1 (NF1) or within the small intestine, and different pathogenetic mechanisms are involved. We report a case of synchronous sporadic gastric and jejunal GISTs, which were resected laparoscopically in a 67-year-old man. Immunohistochemical analysis revealed that both lesions were KIT (CD117)-positive, but that the gastric lesion was CD34-positive, whereas the jejunal one was Vimentin-, S-100-, and SMA-positive. Molecular analysis of mutations in KIT exons 9, 11, 13, and 17, and in PDGFRA exons 12 and 18 revealed the presence of a gastric sporadic GIST with a KIT mutation of the exon 11 and a jejunal sporadic GIST without KIT or PDGFRA mutations. To our knowledge, this is the first report of laparoscopically resected synchronous sporadic gastric and jejunal GISTs.
authors.affiliation: Department of General Surgery, S. Eugenio Hospital, Piazzale dell'Umanesimo 10, 00144 Rome, Italy.
authors.forename: Roberto
authors.initials: R
authors.lastname: Dell'Avanzato
authors.forename: Fabio
authors.initials: F
authors.lastname: Carboni
authors.forename: Maria Beatrice
authors.initials: MB
authors.lastname: Palmieri
authors.forename: Raffaele
authors.initials: R
authors.lastname: Palmirotta
authors.forename: Fiorella
authors.initials: F
authors.lastname: Guadagni
authors.forename: Giovanna
authors.initials: G
authors.lastname: Pippa
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Santeusanio
authors.forename: Mauro
authors.initials: M
authors.lastname: Antimi
authors.forename: Massimo
authors.initials: M
authors.lastname: Lopez
authors.forename: Massimo
authors.initials: M
authors.lastname: Carlini