title: Antifungal and anthelmintic activities of Cleistopholis patens (Annonaceae).
abstract: Basic CH2Cl2 extract of the trunk bark of Cleistopholis patens (Annonaceae) exhibited antifungal activities against Candida albicans, C. parapsilosis, and C. glabrata using an agar well-diffusion assay method. Bioassay-guided fractionation of the extract led to the isolation of 8-hydroxysampangine. The methanolic extract displayed anthelmintic activity against Rhabditis pseudoelongata. Purification of the neutral CH2Cl2 extract yielded bornyl-p-transcoumarate and bornyl-p-cis-coumarate.
authors.affiliation: Département de Pharmacologie, Faculté de Médecine, Université des Sciences de la Santé, Libreville, Gabon. akenblan@yahoo.fr
authors.forename: Blandine
authors.initials: B
authors.lastname: Akendengué
authors.forename: Pierre
authors.initials: P
authors.lastname: Champy
authors.forename: Joseph
authors.initials: J
authors.lastname: Nzamba
authors.forename: François
authors.initials: F
authors.lastname: Roblot
authors.forename: Philippe M
authors.initials: PM
authors.lastname: Loiseau
authors.forename: Christian
authors.initials: C
authors.lastname: Bories