Association between Endothelial Biomarkers and Arterial Elasticity in Young Adults - The CARDIA Study.
BACKGROUND
Reduced arterial elasticity and endothelial dysfunction both may indicate early cardiovascular (CV) disease in young adults. Pulse waveform analysis estimates large (LAE) and small (SAE) artery elasticity noninvasively. We assessed the associations between LAE and SAE and markers of endothelial dysfunction and CV risk factors.


METHODS
The Coronary Artery Risk Development in Young Adults (CARDIA) assessed arterial elasticity and other characteristics cross-sectionally in 389 men and 381 women aged 27-42 years in 1995 (CARDIA year 10) and circulating levels of P-selectin and soluble intercellular adhesion molecule 1 (sICAM-1) in 2000. We adjusted for variables included in the estimation of arterial elasticity (year 10 height, body mass index, age, heart rate, and blood pressure) and other year 10 characteristics.


RESULTS
Mean adjusted SAE was 8.5 vs. 7.6 ml/mmHg x100 in those with urine albumin/creatinine ratio </=4 vs. microalbuminuria (ratio > 25; p(trend) =0.008). Mean LAE was 25.6 vs. 24.2 ml/mmHg x10 in the lowest vs. highest quintile of P-selectin (p(trend) =0.004). sICAM-1 was unrelated to either LAE or SAE. Plasma triglycerides were inversely related to LAE (p(trend) =0.029). Cigarette smokers had lower SAE than nonsmokers (p(trend) = 0.009).


CONCLUSIONS
In addition to smoking and triglycerides, biomarkers for endothelial dysfunction were associated with impaired LAE and SAE in young adults.
Valappil
Narayanan I
NI
Health Resources and Services Administration, 5600 Fishers Lane, Room 7A-42, Rockville, MD 20857.
Jacobs
David R
DR
Duprez
Daniel A
DA
Gross
Myron D
MD
Arnett
Donna K
DK
Glasser
Stephen
S