title: Efficacy and safety of treating T4 oral cavity tumors with primary chemoradiotherapy.
abstract: BACKGROUND
  Patients with T4 oral cavity (OC) tumors are often treated with surgery followed by adjuvant chemoradiotherapy (CRT).
  
  
  METHODS
  We performed a retrospective review of 4 multi-institutional phase II studies estimating long-term toxicity, locoregional control (LC), progression-free survival (PFS), and overall survival (OS) of primary CRT.
  
  
  RESULTS
  Thirty-nine subjects were identified; 16 (42%) with bony involvement. Median radiotherapy dose delivered to primary tumor was 74 Gy. Five-year OS, PFS, and LC rates were 56%, 51%, and 75%, respectively. Sixty-nine percent of subjects with bony involvement never relapsed. Seven subjects developed osteoradionecrosis. Bone involvement with primary tumor did not appear to be associated with increased risk of death, relapse, or long-term complication.
  
  
  CONCLUSIONS
  These data suggest that primary CRT is an effective treatment approach in patients with T4 OC tumors including those with bony involvement producing LC, survival, and complication rates comparable to historical series. Prospective clinical trials should evaluate primary surgical versus CRT treatment in these patients.
authors.affiliation: Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, Illinois, USA.
authors.forename: Ezra E W
authors.initials: EE
authors.lastname: Cohen
authors.forename: Joshua
authors.initials: J
authors.lastname: Baru
authors.forename: Dezheng
authors.initials: D
authors.lastname: Huo
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Haraf
authors.forename: Maureen
authors.initials: M
authors.lastname: Crowley
authors.forename: Mary Ellyn
authors.initials: ME
authors.lastname: Witt
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Blair
authors.forename: Ralph R
authors.initials: RR
authors.lastname: Weichselbaum
authors.forename: Fred
authors.initials: F
authors.lastname: Rosen
authors.forename: Everett E
authors.initials: EE
authors.lastname: Vokes
authors.forename: Kerstin
authors.initials: K
authors.lastname: Stenson