Fishing for a WNT-PGE2 link: beta-catenin is caught in the stem cell net-work.
WNT and PGE2 signaling pathways are each associated with stem cell activity in the hematopoietic system. In a recent issue of Cell, Goessling et al. (2009) use the zebrafish model to reveal a conserved PKA-dependent mechanism that connects the two pathways via beta-catenin, enhancing stem cell proliferation and tissue regeneration.
Evans
Todd
T
Department of Surgery, Weill Cornell Medical College, Cornell University, New York, NY 10021, USA. tre2003@med.cornell.edu