title: A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes.
abstract: In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.
authors.affiliation: Medicinal Chemistry & Chemical Biology, Utrecht Institute of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80082, NL-3508 TB, Utrecht, The Netherlands.
authors.forename: Cristina
authors.initials: C
authors.lastname: Chamorro
authors.forename: John A W
authors.initials: JA
authors.lastname: Kruijtzer
authors.forename: Marina
authors.initials: M
authors.lastname: Farsaraki
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Rob M J
authors.initials: RM
authors.lastname: Liskamp