title: Rational design of organocatalyst: highly stereoselective Michael addition of cyclic ketones to nitroolefins.
abstract: A remarkable organocatalyst that facilitates the asymmetric Michael addition of cyclic ketones to nitroolefins in excellent stereoselectivities (98:2 to >99:1 dr, 92% to >99% ee) has been developed and afforded various types of optically active nitroalkane derivatives of synthetic and biological importance. The extremely simple and practical operational procedure at room temperature increases the attractiveness of this reaction.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Bin
authors.initials: B
authors.lastname: Tan
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zeng
authors.forename: Yunpeng
authors.initials: Y
authors.lastname: Lu
authors.forename: Pei Juan
authors.initials: PJ
authors.lastname: Chua
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong