Stereoselective synthesis of amphidinolide T1.
A highly stereoselective total synthesis of amphidinolide T1 is achieved using Sharpless asymmetric epoxidation, base-induced epoxide opening, radical cyclization, diastereoselective reduction followed by allylation, Evans methylation, base-induced reductive elimination, umpolung reaction, chemoselective oxidation, and regioselective macrolactonization.
Yadav
J S
JS
Organic Chemistry Division I, Indian Institute of Chemical Technology, Hyderabad 500607, India.
Reddy
Ch Suresh
ChS