New naphthoquinone derivatives from the ascomycete IBWF79B-90A.
Bioactivity-guided fractionation of extracts from the fungus IBWF79B-90A resulted in the isolation of three known naphthoquinones, herbarin, dehydroherbarin, and O-methylherbarin and the azaanthraquinone scorpinone as well as three structurally related derivatives, O-phenethylherbarin and herbaridines A and B. All seven compounds exhibited cytotoxic activities against several cell lines.
Schüffler
Anja
A
University of Kaiserslautern, Paul-Ehrlich-Str. 23, D-67663 Kaiserslautern, Germany.
Liermann
Johannes C
JC
Kolshorn
Heinz
H
Opatz
Till
T
Anke
Heidrun
H