title: PBMCs protein expression profile in relapsing IFN-treated multiple sclerosis: A pilot study on relation to clinical findings and brain atrophy.
abstract: This cross-sectional study investigated with two-dimensional gel electrophoresis coupled to MALDI-TOF and MRI the relationship between PBMCs protein expression profile and whole-brain atrophy in 16 unselected RR-MS IFN-treated patients compared with 6 RR IFN-untreated and 12 matched healthy control subjects. Grey/white matter fraction, T1/T2 lesion load and clinical variables were considered too. Twenty six proteins showed significant differential expression among RR IFN-treated patients and control samples. Four of these (IN35, GANAB, PP1B, SEPT2) resulted correlated with clinical and MRI findings in RR IFN-treated MS patients. Future clinical applications remain to be validated by other techniques and confirmed by a larger study.
authors.affiliation: Department of Biological and Environmental Sciences and Technologies, University of Salento, Lecce, Italy.
authors.forename: R
authors.initials: R
authors.lastname: De Masi
authors.forename: D
authors.initials: D
authors.lastname: Vergara
authors.forename: S
authors.initials: S
authors.lastname: Pasca
authors.forename: R
authors.initials: R
authors.lastname: Acierno
authors.forename: M
authors.initials: M
authors.lastname: Greco
authors.forename: L
authors.initials: L
authors.lastname: Spagnolo
authors.forename: E
authors.initials: E
authors.lastname: Blasi
authors.forename: F
authors.initials: F
authors.lastname: Sanapo
authors.forename: G
authors.initials: G
authors.lastname: Trianni
authors.forename: M
authors.initials: M
authors.lastname: Maffia