title: Amiloride derived inhibitors of acid-sensing ion channel-3 (ASIC3).
abstract: A series of amiloride derivatives modified at the 5-position of the pyrazine ring were evaluated as inhibitors of acid-sensing ion channel-3 (ASIC3), a novel target for the treatment of chronic pain.
authors.affiliation: Department of Medicinal Chemistry, Merck Research Laboratories, Sumneytown Pike, PO Box 4, West Point, PA 19486, USA.
authors.forename: Scott D
authors.initials: SD
authors.lastname: Kuduk
authors.forename: Christina N
authors.initials: CN
authors.lastname: Di Marco
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Chang
authors.forename: Robert M
authors.initials: RM
authors.lastname: Dipardo
authors.forename: Sean P
authors.initials: SP
authors.lastname: Cook
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Cato
authors.forename: Aneta
authors.initials: A
authors.lastname: Jovanovska
authors.forename: Mark O
authors.initials: MO
authors.lastname: Urban
authors.forename: Michael
authors.initials: M
authors.lastname: Leitl
authors.forename: Robert H
authors.initials: RH
authors.lastname: Spencer
authors.forename: Stefanie A
authors.initials: SA
authors.lastname: Kane
authors.forename: Mark T
authors.initials: MT
authors.lastname: Bilodeau
authors.forename: George D
authors.initials: GD
authors.lastname: Hartman
authors.forename: Mark G
authors.initials: MG
authors.lastname: Bock