title: [Effects of topical Dry Nose Spray on the transepithelial water loss and potential difference in human nasal mucosa].
abstract: BACKGROUND
  Nasal airway is the entrance to the respiratory tract. The upper airway has function of humidification and secretion. We have already demonstrated the human nasal mucosal water loss as the transepithelial water loss. The aim of this study is to evaluate the short term effect of DryNose TM Spray on the transepithelial loss and alteration of potential difference (PD) in human nasal mucosa.
  
  
  METHODS
  Measurement of transepithelial water loss of nasal mucosa (TEWL) was performed on the inferior nasal turbinate by using Tewamerter TM210 (Courage + Khasaka electric, Germany). PD was measured using the Ussing's technique.
  
  
  RESULTS
  The significant decrease in TEWL was observed after spray. On the other hands, PD did not change after spray.
  
  
  CONCLUSIONS
  The effects of topical application of DryNose Spray on nasal mucosa decreased water loss.
authors.affiliation: Department of Otorhinolaryngology, Koshigaya Hospital, Dokkyo University School of Medicine. n-nakajima.8mr@cfu.nir.jp
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Nakajima
authors.forename: Masato
authors.initials: M
authors.lastname: Miwa
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirose
authors.forename: Mieko
authors.initials: M
authors.lastname: Abe
authors.forename: Kensuke
authors.initials: K
authors.lastname: Watanabe