title: Tucupentol, a novel mono-tetrahydrofuranic acetogenin from Annona montana, as a potent inhibitor of mitochondrial complex I.
abstract: Ten acetogenins, one of them new, were isolated from leaves and twigs of a Bolivian collection of Annona montana. The new compound that we named tucupentol (1) is a mono-tetrahydrofuran-pentahydroxy-acetogenin. The inhibitory potency of tucupentol (1) on the mitochondrial complex I was evaluated, and this activity was compared with that of the known acetogenins, annonacin-A, cis-annonacin-10-one, aromin, and gigantetronenin, also isolated from this plant material. The mentioned acetogenins acted as selective inhibitors of mitochondrial complex I in the 0.8-5.4-nM range.
authors.affiliation: Instituto de Química Orgánica, Facultad de Bioquímica, Química y Farmacia, Universidad Nacional de Tucumán, Tucumán, Argentina.
authors.forename: Olga
authors.initials: O
authors.lastname: Alvarez Colom
authors.forename: Adriana
authors.initials: A
authors.lastname: Neske
authors.forename: Nadia
authors.initials: N
authors.lastname: Chahboune
authors.forename: M Carmen
authors.initials: MC
authors.lastname: Zafra-Polo
authors.forename: Alicia
authors.initials: A
authors.lastname: Bardón