White matter alterations in male patients with obsessive-compulsive disorder.
To investigate white matter abnormalities in patients with obsessive-compulsive disorder and to clarify the relationship between discrete white matter alterations and obsessive-compulsive symptom dimensions, the fractional anisotropy obtained from 25 male patients and 25 matched normal controls were analyzed. The patients had a significantly lower fractional anisotropy in the left anterior cingulate white matter than the controls. When stratified by clinical symptom dimensions, patients with a predominant aggressive/checking symptom dimension exhibited a significantly lower fractional anisotropy in the left anterior cingulate white matter, whereas patients with a predominant contamination/cleaning symptom dimension showed a significantly higher fractional anisotropy in the bilateral prefrontal white matter. Our findings provide evidence that obsessive-compulsive disorder may be a heterogeneous disease with distinct white matter changes.
Ha
Tae Hyon
TH
Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
Kang
Do-Hyung
DH
Park
Jun Sung
JS
Jang
Joon Hwan
JH
Jung
Wi Hoon
WH
Choi
Jung-Seok
JS
Park
Ji-Young
JY
Jung
Myung Hun
MH
Choi
Chi-Hoon
CH
Lee
Jong-Min
JM
Ha
Kyooseob
K
Kwon
Jun Soo
JS