title: Layer-by-layer assembled gold nanoparticles for siRNA delivery.
abstract: Although uptake into cells is highly complex and regulated, heterogeneous particle collectives are usually employed to deliver small interfering RNA (siRNA) to cells. Within these collectives, it is difficult to accurately identify the active species, and a decrease in efficacy is inherent to such preparations. Here, we demonstrate the manufacture of uniform nanoparticles with the deposition of siRNA on gold in a layer-by-layer approach, and we further report on the cellular delivery and siRNA activity as functions of surface properties.
authors.affiliation: Department of Pharmaceutical Technology, University of Regensburg, 93040 Regensburg, Germany.
authors.forename: Asmaa
authors.initials: A
authors.lastname: Elbakry
authors.forename: Alaa
authors.initials: A
authors.lastname: Zaky
authors.forename: Renate
authors.initials: R
authors.lastname: Liebl
authors.forename: Reinhard
authors.initials: R
authors.lastname: Rachel
authors.forename: Achim
authors.initials: A
authors.lastname: Goepferich
authors.forename: Miriam
authors.initials: M
authors.lastname: Breunig