Synthesis, characterization and cytotoxicity of dihalogeno-platinum(II) complexes with L-histidine ligand.
Diiodo-, dibromo- and dichloro-platinum(II) complexes containing L-histidine ligand were prepared. Their spectra and X-ray crystal structure of the dibromo-platinum(II) complex were described. Only the dichloro-platinum(II) complex showed comparable cytotoxic activity with carboplatin against A549/ATCC, HT-29, and LNcap cell lines. Nevertheless the complexes with COOH-substituted ligands histidine may be good starting materials to synthesize targeting platinum complexes since they could be easily linked to suitable carrier molecules via esterification.
Ye
Qing-Song
QS
Platinum-Based Drug Lab, Kunming Institute of Precious Metals, Kunming, Yunnan, China.
Xie
Ming-Jin
MJ
Liu
Wei-Ping
WP
Chen
Xi-Zhu
XZ
Yu
Yao
Y
Chang
Qiao-Wen
QW
Hou
Shu-Qian
SQ