[Peculiarities of genotype distribution of interleukins (IL-1 and IL-10) in patients with peptic ulcer disease and their associations with persistence of Mycoplasma hyorhinis and Helicobacter pylori genotypes].
It was found for the first time in our study that there is a significant prevalence of combinations of IL-1 and IL-10 genotypes--IL-1B-511C/C, IL-1B+3954C/C, IL-1RN1/1, IL-10-1082A/A and IL-1B-511T/C, IL-1B+3954C/C, IL-1RN1/2, IL-10- 1082A/G--in the group of patients with gastric and duodenal ulcer disease and control one, respectively. The correlation between the Tox- (cagA- vacAs1-) strains of H. pylori and the combinations of genotypes IL-1B-511T/C, IL-1B +3954C/C, IL-1RN1/1, IL-10-1082G/G was shown (p <0,05). Co-infection with H. pylori and M. hyorhinis was detected in 19% of patients. The association between combinations of genotypes IL-1B-511T/T IL-1B+3954C/C, IL-1RN2/2, IL-10-1082A/G and co-infection with H. pylori and M. hyorhinis was also found (p <0,05).
Abuzarova
E R
ER
Gorshkov
O V
OV
Chernova
O A
OA
Chernov
V M
VM
Akberova
N I
NI
Abdulkhakov
R A
RA