title: Proteomic Helicobacter pylori biomarkers discriminating between duodenal ulcer and gastric cancer.
abstract: Protein patterns of 129 Helicobacter pylori strains isolated from Korean and Colombian patients suffering from duodenal ulcer or gastric cancer were analyzed by the high-throughput methodology SELDI-TOF-MS. Eighteen statistically significant candidate biomarkers discriminating between the two clinical outcomes were selected by using the Mann-Whitney test. Three biomarker proteins were purified and identified as a neutrophil-activating protein NapA (HU HPAG1_0821), a RNA-binding protein (HPAG1_0813), and a DNA-binding histone-like protein HU, respectively (jhp0228). These novel biomarkers can be used for development of diagnostic assays predicting the evolution to gastric cancer in H. pylori-infected patients.
authors.affiliation: EA 4331 LITEC, Université de Poitiers, Poitiers, France.
authors.forename: Ghalia
authors.initials: G
authors.lastname: Khoder
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Yamaoka
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Fauchère
authors.forename: Christophe
authors.initials: C
authors.lastname: Burucoa
authors.forename: Christo
authors.initials: C
authors.lastname: Atanassov