title: Need for thiamine in peripheral parenteral nutrition after abdominal surgery in children.
abstract: BACKGROUND
  Thiamine blood concentrations of pediatric patients receiving peripheral parenteral nutrition change during the postoperative period. In addition, the need to administer thiamine after surgery has not yet been fully studied in children receiving peripheral parenteral nutrition.
  
  
  OBJECTIVE
  The objective of this prospective study is to clarify whether pediatric patients require the administration of thiamine while receiving peripheral parenteral nutrition after abdominal surgery.
  
  
  METHODS
  Fifteen children were divided into 2 groups; 1 group received peripheral parenteral nutrition without thiamine after surgery (n = 7), whereas the other group received peripheral parenteral nutrition with thiamine after surgery (n = 8). In both groups, thiamine blood concentrations were measured on the preoperative day, and changes in thiamine concentration over time were measured during the starvation period from the first to the fifth postoperative day.
  
  
  RESULTS
  Preoperative thiamine blood concentrations were within the normal range in both groups. In the group receiving peripheral parenteral nutrition without thiamine, the thiamine concentration gradually decreased with time after the operation, whereas the concentration remained within the normal range in the group receiving peripheral parenteral nutrition with thiamine. Among the 7 patients receiving peripheral parenteral nutrition without thiamine, the thiamine concentration in 3 patients was below the normal range on the fifth postoperative day.
  
  
  CONCLUSIONS
  During the starvation period after abdominal surgery, thiamine blood concentrations decreased in pediatric patients receiving peripheral parenteral nutrition without thiamine. Therefore, clinicians treating pediatric patients should add thiamine to the peripheral parenteral nutrition solution during the short starvation period after abdominal surgery.
authors.affiliation: Department of Pediatric Surgery, Reproductive and Developmental Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. kmasu@pedsurg.med.kyushu-u.ac.jp
authors.forename: Kouji
authors.initials: K
authors.lastname: Masumoto
authors.forename: Genshiro
authors.initials: G
authors.lastname: Esumi
authors.forename: Risa
authors.initials: R
authors.lastname: Teshiba
authors.forename: Kouji
authors.initials: K
authors.lastname: Nagata
authors.forename: Takanori
authors.initials: T
authors.lastname: Nakatsuji
authors.forename: Yuko
authors.initials: Y
authors.lastname: Nishimoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ieiri
authors.forename: Naoko
authors.initials: N
authors.lastname: Kinukawa
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Taguchi