Serum adipocytokine levels in prostate cancer patients.
BACKGROUND
We estimated the circulating levels of adipocytokines such as adiponectin and leptin in nonobese nondiabetic prostate cancer (PCa) patients and compared the results with controls and benign prostate hyperplasia (BPH) patients.


METHODS
Fifty patients with PCa, 20 patients with BPH and 50 healthy volunteers were entered into the study. Their blood samples were investigated for adipocytokines with the ELISA method.


RESULTS
Adiponectin levels were determined as 8.9 and 5.5 microg/ml for the same patients. Leptin concentration was 14.78 ng/ml in organ-confined PCa patients, and 15.24 ng/ml in advanced PCa patients. In control patients, adiponectin and leptin levels were 18.4 and 12.98 ng/ml, respectively.


CONCLUSIONS
Serum adipocytokine levels of PCa patients were significantly different from those of controls and BPH patients who were not obese or diabetic. Therefore, further molecular investigation of these adipocytokines will help understand the mechanism.
Arisan
Elif Damla
ED
1st Urology Clinics, Sişli Etfal Research and Training Hospital, Sisli-Istanbul, Turkey.
Arisan
Serdar
S
Atis
Gokhan
G
Palavan-Unsal
Narcin
N
Ergenekon
Erbil
E