Harnessing nature's toolbox: regulatory elements for synthetic biology.
Synthetic biologists seek to engineer complex biological systems composed of modular elements. Achieving higher complexity in engineered biological organisms will require manipulating numerous systems of biological regulation: transcription; RNA interactions; protein signalling; and metabolic fluxes, among others. Exploiting the natural modularity at each level of biological regulation will promote the development of standardized tools for designing biological systems.
Boyle
Patrick M
PM
Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.
Silver
Pamela A
PA