Quantitative study of placental villi in trisomy by analytical morphometry.
OBJECTIVE
To assess the relationship between morphologic features of placental villi and the occurrence of trisomy.


METHODS
We selected 9 placentas with genetically diagnosed trisomy 21 and 6 normal placentas of matched gestational age. The 150 selected villi underwent a morphometric study using the Shape Analytical Morphometry system, availing itself of an ordinary section to study dimensions and of a specific section to study the shape. The analytic morphometric procedure for shape analysis consisted of 3 steps: upper degree polynomial equations, Fourier analysis and parabolic fitting.


RESULTS
Trisomic villi showed bigger size and a more asymmetric and irregular shape than did normal villi.


CONCLUSIONS
We believe that this method can provide valuable information and that further studies are needed to analyze more cohorts of pathologic villi, thus providing a complete pattern of morphologic aberrations related to each placental disease.
Ricco
Rosalia
R
Department of Anatomic Pathology, University of Bari, Bari Italy. ricco@anatopat.uniba.it
Dalena
Anna Maria
AM
Valente
Tiziana
T
Lettini
Teresa
T
Sanguedolce
Francesca
F
Delfino
Antonella R Pesce
AR