title: Biologically active cannabinoids from high-potency Cannabis sativa.
abstract: Nine new cannabinoids (1-9) were isolated from a high-potency variety of Cannabis sativa. Their structures were identified as (+/-)-4-acetoxycannabichromene (1), (+/-)-3''-hydroxy-Delta((4'',5''))-cannabichromene (2), (-)-7-hydroxycannabichromane (3), (-)-7R-cannabicoumarononic acid A (4), 5-acetyl-4-hydroxycannabigerol (5), 4-acetoxy-2-geranyl-5-hydroxy-3-n-pentylphenol (6), 8-hydroxycannabinol (7), 8-hydroxycannabinolic acid A (8), and 2-geranyl-5-hydroxy-3-n-pentyl-1,4-benzoquinone (9) through 1D and 2D NMR spectroscopy, GC-MS, and HRESIMS. The known sterol beta-sitosterol-3-O-beta-d-glucopyranosyl-6'-acetate was isolated for the first time from cannabis. Compounds 6 and 7 displayed significant antibacterial and antifungal activities, respectively, while 5 displayed strong antileishmanial activity.
authors.affiliation: Department of Pharmaceutics, National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, Mississippi 38677, USA.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Radwan
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: Elsohly
authors.forename: Desmond
authors.initials: D
authors.lastname: Slade
authors.forename: Safwat A
authors.initials: SA
authors.lastname: Ahmed
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross