title: Favourable prognosis with modified dosing of docetaxel and cisplatin in Japanese patients with ovarian cancer.
abstract: BACKGROUND
  The long-term efficacy and safety of docetaxel/cisplatin as first-line chemotherapy in Japanese patients was evaluated in order to find an optional regimen for ovarian cancer.
  
  
  METHODS
  Women with surgically resected stage Ic-IV epithelial ovarian cancer were treated with docetaxel 70 mg/m2 and cisplatin 60 mg/m2 every 4 weeks.
  
  
  RESULTS
  Ninety women were enrolled of whom 89 (median age, 54 years) received a median of 6 cycles (range 1 to 9). With a median 38 months'follow-up, median progression-free survival was 28 months (95% lower confidence interval, 24 months) in 60 patients with stage III-IV disease. The overall response rate for 20 patients was 45%. Neutropenia was the most common (67%) grade 3/4 toxicity. Major grade 3/4 nonhaematological toxicities were gastrointestinal toxicities (< or = 11%) and fatigue (8%). No grade 3/4 neurotoxicity was observed.
  
  
  CONCLUSIONS
  The combination of docetaxel/cisplatin is a regimen with favourable progression-free survival for ovarian cancer.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Keio University, Tokyo, 160-8582, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Aoki
authors.forename: Yoh
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Toshiko
authors.initials: T
authors.lastname: Jobo
authors.forename: Kimio
authors.initials: K
authors.lastname: Ushijima
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Hasegawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Susumu
authors.forename: Nao
authors.initials: N
authors.lastname: Suzuki
authors.forename: Rui
authors.initials: R
authors.lastname: Aoki
authors.forename: Seiji
authors.initials: S
authors.lastname: Isonishi
authors.forename: Satoru
authors.initials: S
authors.lastname: Sagae
authors.forename: Bunpei
authors.initials: B
authors.lastname: Ishizuka
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Kamura
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Udagawa
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hoshiai
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Ochiai
authors.forename: Kiichiro
authors.initials: K
authors.lastname: Noda