Translocation of a thioether-bridged azurin peptide fragment via the sec pathway in Lactococcus lactis.
This study demonstrates for the first time that a thioether-containing peptide, an azurin fragment, can be translocated via the Sec pathway. This methyl-lanthionine was introduced by the nisin modification enzymes. The Sec pathway can therefore be a successful alternative for those cyclized peptides that are inefficiently transported via NisT.
Kuipers
Anneke
A
BiOMaDe Technology Foundation, Nijenborgh, AG Groningen, The Netherlands.
Rink
Rick
R
Moll
Gert N
GN