title: Studies of the photooxidant properties of antibacterial fluoroquinolones and their naphthalene derivatives.
abstract: We synthesized and determined the production of reactive oxygen species (ROS) as 1O2, *-O2, *OH, H2O2 during the photolysis with UV-A light of three antibacterial quinolones and their naphthyl ester derivatives. Singlet oxygen and ROS dose-dependant generation from norfloxacin (1), enoxacin (2), ciprofloxacin (3) and their respective naphthyl ester derivatives 4-6 were detecting in cell-free systems by the histidine assay and by luminol-enhanced chemiluminescence (LCL). Both the electronic absorption and emission spectra were quantified and their photostability determined. The antibacterial activity in darkness and under irradiation of compounds 4, 5 and 6 was tested on E. coli and compared with their parent drugs.
authors.affiliation: Laboratorio de Fotoquímica, Centro de Química, Instituto Venezolano de Investigaciones Científicas I.V.I.C., Carretera Panamericana Klm. 11, Apartado 20632, Caracas 1020-A, Venezuela. fvargas@ivic.ve
authors.forename: F
authors.initials: F
authors.lastname: Vargas
authors.forename: T
authors.initials: T
authors.lastname: Zoltan
authors.forename: A H
authors.initials: AH
authors.lastname: Ramirez
authors.forename: T
authors.initials: T
authors.lastname: Cordero
authors.forename: V
authors.initials: V
authors.lastname: Chavez
authors.forename: C
authors.initials: C
authors.lastname: Izzo
authors.forename: V
authors.initials: V
authors.lastname: López
authors.forename: Y M
authors.initials: YM
authors.lastname: Cárdenas
authors.forename: A
authors.initials: A
authors.lastname: Fernández
authors.forename: L
authors.initials: L
authors.lastname: Hincapie
authors.forename: A
authors.initials: A
authors.lastname: Fuentes