[Expressions of CD1a and CD83 of Langerhans cells in the local lesions of epidermodysplasia verruciformis patients].
OBJECTIVE
To investigate the expressions of CD1a and CD83 of Langerhans cells (LC) in the lesions of epidermodysplasia verruciformis (EV) patients.


METHODS
We used immunohistochemical method to detect the expressions of CD1a and CD83 in the lesions of 10 patients with EV lesions and in the skins of 10 normal subjects.


RESULTS
No CD83 + LCs was detected in all EV patients and normal controls, but CD1a + LC was found in all cases. The quantity of CD1a + LCs in the lesions of EV patients was significantly lower than that in the normal skin (P < 0.01); furthermore, the distribution of LCs in EV lesions was uneven.


CONCLUSIONS
The functions of LCs may be inhibited in EV patients.
Liang
Si
S
Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Liu
Yue-Hua
YH
Zuo
Ya-Gang
YG
Wang
Bao-Xi
BX
Fang
Kai
K