title: Angiopoietin-2 promoter haplotypes confer an increased risk of stroke in a Chinese Han population.
abstract: Angiopoietin-2 is an important mediator of angiogenesis, and we hypothesized that genetic variants of ANGPT2 (the gene encoding angiopoietin-2) would result in abnormal angiogenesis and contribute to stroke susceptibility. To test our hypothesis, we investigated the association of variants in the promoter of ANGPT2 with stroke in a multi-centre case-control study. We found that the C allele of rs3739390 conferred a 1.42-fold risk of lacunar infarction {adjusted OR (odds ratio), 1.42 [95% CI (confidence interval), 1.08-1.87]; P=0.012} and a 2.10-fold higher transcriptional activity than did the corresponding G allele rs3739390G. The haplotype G-G-T conferred a 1.54-fold risk of atherothrombotic stroke and a 1.64-fold risk for haemorrhagic stroke, whereas the haplotype G-C-C conferred approx. a 2.0-fold risk of each subtype of stroke. In conclusion, our results indicate that haplotypes in the promoter of ANGPT2 confer a high risk of stroke in a Chinese population.
authors.affiliation: Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Jingzhou
authors.initials: J
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Weihua
authors.initials: W
authors.lastname: Song
authors.forename: Kai
authors.initials: K
authors.lastname: Sun
authors.forename: Yan
authors.initials: Y
authors.lastname: Song
authors.forename: Kejia
authors.initials: K
authors.lastname: Lou
authors.forename: Tao
authors.initials: T
authors.lastname: Yang
authors.forename: Yinhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Rutai
authors.initials: R
authors.lastname: Hui