title: Using the Stroop task to investigate the neural correlates of symptom change in schizophrenia.
abstract: This study examined brain activation during a cognitive inhibition task in patients with schizophrenia following changes in their positive symptoms. A Stroop task was used during functional magnetic resonance imaging in 11 patients with schizophrenia (patient group) and 9 healthy volunteers (control group). At baseline, the patient group showed significantly attenuated activation within the anterior cingulate gyrus, left pre-/postcentral gyrus and inferior frontal junction. At follow-up, there was a significant increase in activation in the left inferior frontal junction associated with a decrease in positive symptoms, suggesting this region plays a role in the development of these symptoms.
authors.affiliation: Department of Psychiatry and Neuropsychology, Maastricht University, PO BOX 616 (location VIJV), 6200 MD Maastricht, The Netherlands. l.krabbendam@sp.unimaas.nl
authors.forename: Lydia
authors.initials: L
authors.lastname: Krabbendam
authors.forename: Owen
authors.initials: O
authors.lastname: O'Daly
authors.forename: Lucy A
authors.initials: LA
authors.lastname: Morley
authors.forename: Jim
authors.initials: J
authors.lastname: van Os
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: Sukhwinder S
authors.initials: SS
authors.lastname: Shergill