title: Development of a concise and general enantioselective approach to 2,5-disubstituted-3-hydroxytetrahydrofurans.
abstract: Concise syntheses of 2,5-disubstituted-3-hydroxytetrahydrofurans have been developed that provide access to each configurational isomer of this scaffold from a single aldol adduct. Application of these methods to the rapid preparation of (6S,7S,9S,10S)- and (6S,7S,9R,10R)-6,9-epoxynonadec-18-ene-7,10-diol, two structurally related marine epoxylipids, is reported.
authors.affiliation: Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC, Canada.
authors.forename: Baldip
authors.initials: B
authors.lastname: Kang
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Mowat
authors.forename: Thomas
authors.initials: T
authors.lastname: Pinter
authors.forename: Robert
authors.initials: R
authors.lastname: Britton