Asymmetric generation of fluorine-containing quaternary carbons adjacent to tertiary stereocenters: uses of fluorinated methines as nucleophiles.
Organocatalytic asymmetric Michael reactions of fluorinated nucleophiles with nitroolefins catalyzed by Cinchona alkaloid-derived thiourea catalysts generated the desired Michael products containing vicinal fluorinated quaternary and tertiary chiral centers with exceptional enantioselectivity.
Han
Xiao
X
Department of Chemistry, National University of Singapore, Singapore, Republic of Singapore.
Luo
Jie
J
Liu
Chen
C
Lu
Yixin
Y