title: Construction of carbo- and heterocycles using radical relay cyclizations initiated by alkoxy radicals.
abstract: An efficient method for the rapid construction of carbo- and heterocycles has been developed using radical relay cyclizations initiated by alkoxy radicals. Linear substrates were cyclized to form a wide range of cyclopentane, pyrrolidine, tetrahydropyran, and tetrahydrofuran derivatives in excellent yields. This methodology was utilized as a key step in the synthesis of the tetrahydrofuran fragment in (-)-amphidinolide K.
authors.affiliation: Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
authors.forename: Hai
authors.initials: H
authors.lastname: Zhu
authors.forename: Jason G
authors.initials: JG
authors.lastname: Wickenden
authors.forename: Natalie E
authors.initials: NE
authors.lastname: Campbell
authors.forename: Joe C T
authors.initials: JC
authors.lastname: Leung
authors.forename: Kayli M
authors.initials: KM
authors.lastname: Johnson
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Sammis