Expression of CCN family of genes in human skin in vivo and alterations by solar-simulated ultraviolet irradiation.
The CCN family of proteins is involved in diverse biological functions such as cell growth, adhesion, migration, angiogenesis, and regulation of extracellular matrix. We have investigated expression of CCN family genes and alternations induced by solar-simulated ultraviolet irradiation in human skin in vivo. Transcripts of all six CCN genes were expressed in human skin in vivo. CCN5 was most abundantly expressed followed by CCN2>CCN3>CCN1>CCN4>CCN6. Solar-simulated ultraviolet irradiation increased mRNA expression of CCN1 and CCN2. In contrast, mRNA levels of CCN3, CCN4, CCN5, and CCN6, were reduced. Knowledge gained from this study provides the foundation to explore the functional roles of CCN gene products in cutaneous biology and responses to solar ultraviolet irradiation.
Quan
Taihao
T
Department of Dermatology, University of Michigan, 1150 W. Medical Center Drive, Med Sci 1, Room 6447, Ann Arbor, MI, 48109-5609, USA, thquan@umich.edu.
Shin
Sharon
S
Qin
Zhaoping
Z
Fisher
Gary J
GJ