Palladium-catalyzed highly diastereoselective oxidative cascade cyclization reactions.
Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)(2)/isoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr > 24:1).
Yip
Kai-Tai
KT
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
Zhu
Nian-Yong
NY
Yang
Dan
D