Lung cancer susceptibility and genetic polymorphisms of Exo1 gene in Taiwan.
OBJECTIVE
To evaluate the association between the polymorphisms of the Exo1 gene and the risk of lung cancer in central Taiwan.


METHODS
In this hospital-based study, the association of Exol A-1419G (rs3754093), C-908G (rs10802996), A238G (rs1776177), C498T (rs1635517), K589E (rs1047840), G670E (rs1776148), C723R (rs1635498), L757P (rs9350) and C3114T (rs851797) polymorphisms with lung cancer risk in a central Taiwanese population was investigated. In total, 358 patients with lung cancer and 358 age- and gender-matched healthy controls recruited from the China Medical Hospital in central Taiwan were genotyped.


RESULTS
A significantly different distribution was found in the frequency of the Exo1 K589E genotype, but not the other genotypes, between the lung cancer and control groups. The A allele Exo1 K589E conferred a significantly (p = 0.0097) increased risk of lung cancer. As for the rest of the polymorphisms, there was no difference in distribution between the lung cancer and control groups. Gene environment interactions with smoking were significant for Exo1 K589E polymorphism. The Exo1 K589E AG and AA genotype in association with smoking conferred an increased risk of 1.7208 (95% confidence interval = 1.2188-2.4295) for lung cancer.


CONCLUSIONS
Our results provide the first evidence that the A allele of Exo1 K589E may be associated with the development of lung cancer and may be a novel useful marker for primary prevention and anticancer intervention.
Hsu
Nan-Yung
NY
Department of Chest Surgery, China Medical University Hospital, Taichung, Taiwan, ROC.
Wang
Hwei-Chung
HC
Wang
Chung-Hsing
CH
Chiu
Chang-Fang
CF
Tseng
Hsien-Chang
HC
Liang
Shiu-Yun
SY
Tsai
Chia-Wen
CW
Lin
Cheng-Chieh
CC
Bau
Da-Tian
DT