title: Striatal dopamine D2 binding is related to frontal BOLD response during updating of long-term memory representations.
abstract: Multi-modal brain imaging was used to examine the relation between individual differences in resting-state striatal dopamine D2 binding and the magnitude of prefrontal BOLD activation during updating of long-term memory (LTM) representations. Increased activity in the left prefrontal cortex was observed when LTM updating was required, and there was a positive correlation between striatal D2 activity and the magnitude of left prefrontal activity during updating. These findings support predictions from neurocomputational models of a relation of dopaminergic neurotransmission to transient cognitive operations and related brain activity.
authors.affiliation: Department of Radiation Sciences, Diagnostic Radiology, Umeå University, Sweden. Lars.Nyberg@diagrad.umu.se
authors.forename: Lars
authors.initials: L
authors.lastname: Nyberg
authors.forename: Micael
authors.initials: M
authors.lastname: Andersson
authors.forename: Lars
authors.initials: L
authors.lastname: Forsgren
authors.forename: Susanna
authors.initials: S
authors.lastname: Jakobsson-Mo
authors.forename: Anne
authors.initials: A
authors.lastname: Larsson
authors.forename: Petter
authors.initials: P
authors.lastname: Marklund
authors.forename: Lars-Göran
authors.initials: LG
authors.lastname: Nilsson
authors.forename: Katrine
authors.initials: K
authors.lastname: Riklund
authors.forename: Lars
authors.initials: L
authors.lastname: Bäckman