title: Anti-tuberculosis drug resistance and HIV co-infection in Phnom Penh, Cambodia.
abstract: The objective of this study was to observe the prevalence of drug resistance in Mycobacterium tuberculosis isolates in HIV associated tuberculosis co-infected patients in Phnom Penh City. The isolates of M. tuberculosis were collected during active laboratory-based surveillance. Of the 98 isolates studied, M. tuberculosis resistance to isoniazid was seen in 23.5%, resistance to rifampicin was seen in 16.3% and multidrug-resistance (MDR-TB) was seen in 5.1%. Our findings reveal an alarmingly high level of resistance to isoniazid and rifampicin, and confirms the need for drug susceptibility testing to guide treatment in patients with culture positive tuberculosis.
authors.affiliation: Laboratory for Mycobacteriology, Unit of Clinical Testing, Institut Pasteur du Cambodge, Phnom Penh, Kingdom of Cambodia. sborann@pasteur-kh.org
authors.forename: Borann
authors.initials: B
authors.lastname: Sar
authors.forename: Chantary
authors.initials: C
authors.lastname: Keo
authors.forename: Chanthy
authors.initials: C
authors.lastname: Leng
authors.forename: Manil
authors.initials: M
authors.lastname: Saman
authors.forename: Doung Chan
authors.initials: DC
authors.lastname: Min
authors.forename: Sarin
authors.initials: S
authors.lastname: Chan
authors.forename: Didier
authors.initials: D
authors.lastname: Monchy
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Sarthou